M N Saha

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. M N Saha. Articles written in Resonance – Journal of Science Education. Volume 3 Issue 5 May 1998 pp 84-96 Classics. The Origin of Mass in Neutrons and Protons · M N Saha · More Details Fulltext PDF ...

Tanusri Saha-Dasgupta

Indian Academy of Sciences (India)

Email: tanusri@bose.res.in. Tanusri Saha-Dasgupta, SN Bose National Centre for Basic Sciences, Kolkata, elected to Fellowship in 2010. Saha-Dasgupta works in the area of computational condensed matter physics. She is a recipient of Swarnajayanti Fellowship, and the MRSI-ICSC Superconductivity & Materials Science ...

M Saha Sarkar

Indian Academy of Sciences (India)

Home; Journals; Pramana – Journal of Physics. M Saha Sarkar. Articles written in Pramana – Journal of Physics. Volume 57 Issue 1 July 2001 pp 165-169 Contributed Papers : Nuclear spectroscopy. Level structures ofMo – A comparative study · J M Chatterjee M Saha Sarkar S Bhattacharya P Banerjee S Sarkar R P Singh ...

Saha equation in Rindler space

Indian Academy of Sciences (India)

Sanchari De

2017-05-31

May 31, 2017 ... scenario, the flat local geometry is called the Rindler space. For an illustration, let us consider two reference ... the local acceleration of the frame. To investigate Saha equation in a uniformly acceler- ... the best of our knowledge, the study of Saha equa- tion in Rindler space has not been reported earlier.

Mr Bikash Sinha, Director of SAHA & VECC and Prof. Rolf Heuer, Director general of CERN, sign a collaboration agreements between SAHA (Saha Institute of Nuclear Physics), VECC (Variable Energy Cyclotron Centre), India and CERN ISOLDE.

CERN Multimedia

Maximilien Brice

2009-01-01

Mr Bikash Sinha, Director of SAHA & VECC and Prof. Rolf Heuer, Director general of CERN, sign a collaboration agreements between SAHA (Saha Institute of Nuclear Physics), VECC (Variable Energy Cyclotron Centre), India and CERN ISOLDE.

supradip saha

Indian Academy of Sciences (India)

Marker-assisted introgression of opaque2 allele for rapid conversion of elite hybrids into quality protein maize · FIROZ HOSSAIN VIGNESH MUTHUSAMY NEHA PANDEY ASHISH K. VISHWAKARMA AANCHAL BAVEJA RAJKUMAR U. ZUNJARE NEPOLEAN THIRUNAVUKKARASU SUPRADIP SAHA KANCHIKERI M.

nabanita saha

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. NABANITA SAHA. Articles written in Bulletin of Materials Science. Volume 41 Issue 2 April 2018 pp 55. Green synthesis of silver nanoparticles and biopolymer nanocomposites: a comparative study on physico-chemical, antimicrobial and anticancer activity · RAMASUBBA ...

ritabrata saha

Indian Academy of Sciences (India)

RITABRATA SAHA. Articles written in Indian Academy of Sciences Conference Series. Volume 1 Issue 1 December 2017 pp 67-75 Proceedings of the Conference on Perspectives in Nonlinear Dynamics - 2016. Flow dynamic study of a single-phase square NCL using recurrence plot and recurrence quantification.

sanjoy saha

Indian Academy of Sciences (India)

SANJOY SAHA. Articles written in Journal of Chemical Sciences. Volume 130 Issue 1 January 2018 pp 9. Physico-chemical characterization and biological studies of newly synthesized metal complexes of an Ionic liquid-supported Schiff base: 1-{2-[(2-hydroxy-5-bromobenzylidene)amino]ethyl}-3- ethylimidazolium ...

Dipankar Saha

Indian Academy of Sciences (India)

Home; Journals; Journal of Earth System Science. Dipankar Saha. Articles written in Journal of Earth System Science. Volume 123 Issue 6 August 2014 pp 1335-1347. Geomorphologic, stratigraphic and sedimentologic evidences of tectonic activity in Sone–Ganga alluvial tract in Middle Ganga Plain, India · Sudarsan Sahu ...

uttiyoarnab saha

Indian Academy of Sciences (India)

Home; Journals; Pramana – Journal of Physics. UTTIYOARNAB SAHA. Articles written in Pramana – Journal of Physics. Volume 90 Issue 4 April 2018 pp 46 Research Article. Neutron radiation damage studies in the structural materials of a 500 MWe fast breeder reactor using DPA cross-sections from ENDF/B-VII.1.

Sayanti Saha

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Sayanti Saha. Articles written in Resonance – Journal of Science Education. Volume 10 Issue 3 March 2005 pp 28-34 General Article. “That which we call a rose by any other name would smell as sweet”: How the Nose knows! - Nobel Prize in Physiology or ...

koushik saha

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. KOUSHIK SAHA. Articles written in Journal of Chemical Sciences. Volume 128 Issue 7 July 2016 pp 1025-1032 Regular Article. Reactivity of [Cp*Mo(CO)₃Me] with chalcogenated borohydrides Li[BH₂E₃] and Li[BH₃EFc] (Cp* = (ŋ⁵-C₅Me₅); E = S, Se or Te; ...

Ecuadorile maksti, et ta jätaks rahule Amazonase nafta / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2010-01-01

Yasuni rahvuspargis asuv naftaleiukoht jäetakse vähemalt kümneks aastaks rahule, sest ÜRO loodud fondi kaudu makstakse Ecuadori riigikassasse 3,6 miljardit dollarit ehk ligemale pool summast, mille ta võiks nafta müügist teenida

subhas chandra saha

Indian Academy of Sciences (India)

Home; Journals; Sadhana. SUBHAS CHANDRA SAHA. Articles written in Sadhana. Volume 41 Issue 5 May 2016 pp 549-559. A comparative study of multiple regression analysis and back propagation neural network approaches on plain carbon steel in submerged-arc welding · ABHIJIT SARKAR PRASENJIT DEY R N ...

Rahul Sankrityayan and the Founding of the Ladakh Buddhist Education Society in 1933

DEFF Research Database (Denmark)

Bray, John; Beek, Martijn van; Angdruktsang, Tsering

Rahul Sankrityayan and the Founding of the Ladakh Buddhist Education Society in 1933 Martijn van Beek, John Bray and Tsering Gonkatsang In 1933 Rahul Sankrityayan made his second visit to Ladakh—the first had been in 1926—and spent the months of July to September in and around Leh. During...... this period he worked closely with local Buddhist leaders, and was instrumental in setting up the Ladakh Buddhist Education Society (LBES). Many of the leaders of the LBES were among the first office-bearers of the Ladakh Buddhist Association (LBA) in 1938. The foundation of the LBES is therefore...... independence, but are now hard to find. So far we have been able to track down printed editions of the first and second volumes, and we have also been able to study a manuscript draft of the third volume, which is in the possession of Tsetan Phuntsog’s family. In this paper we present a preliminary analysis...

Rethinking Neo-Vedānta: Swami Vivekananda and the Selective Historiography of Advaita Vedānta

Czech Academy of Sciences Publication Activity Database

Madaio, James

2017-01-01

Roč. 8, č. 101 (2017) E-ISSN 2077-1444 Institutional support: RVO:68378009 Keywords : Swami Vivekananda * Neo-Vedanta * Advaita Vedanta * modern Hinduism Subject RIV: AA - Philosophy ; Religion OBOR OECD: Religious studies http://www.mdpi.com/2077-1444/8/6/101

Saha's ionization equation for high Z elements

International Nuclear Information System (INIS)

Godwal, B.K.; Sikka, S.K.

1977-01-01

Saha's ionization equation has been solved for high Z elements with the aim of providing input for opacity calculations. Results are presented for two elements, tungsten and uranium. The ionization potentials have been evaluated using the simple Bhor's formula with suitable effective charges for ions. The reliability of the free electron density, ion concentrations, etc., obtained from the Saha's equation solutions has been checked by comparing the P and E computed from them with those given by the Thomas-Fermi-Dirac equation of state. The agreement between the two is good from temperatures above 0.2 keV. (author)

On the Saha Ionization Equation

Indian Academy of Sciences (India)

Abstract. We revisit the Saha Ionization Equation in order to highlightthe rich interdisciplinary content of the equation thatstraddles distinct areas of spectroscopy, thermodynamics andchemical reactions. In a self-contained discussion, relegatedto an appendix, we delve further into the hidden message ofthe equation in terms ...

The HDAC inhibitor SAHA does not rescue CFTR membrane expression in Cystic Fibrosis.

Science.gov (United States)

Bergougnoux, Anne; Petit, Aurélie; Knabe, Lucie; Bribes, Estelle; Chiron, Raphaël; De Sario, Albertina; Claustres, Mireille; Molinari, Nicolas; Vachier, Isabelle; Taulan-Cadars, Magali; Bourdin, Arnaud

2017-07-01

The development of suitable Cystic Fibrosis (CF) models for preclinical bench tests of therapeutic candidates is challenging. Indeed, the validation of molecules to rescue the p.Phe508del-CFTR channel (encoded by the Cystic Fibrosis Transmembrane conductance Regulator gene carrying the p.Phe508del mutation) requires taking into account their overall effects on the epithelium. Suberoylanilide Hydroxamic Acid (SAHA), a histone deacetylase inhibitor (HDACi), was previously shown to be a CFTR corrector via proteostasis modulation in CFTR-deficient immortalized cells. Here, we tested SAHA effects on goblet cell metaplasia using an ex vivo model based on the air-liquid interface (ALI) culture of differentiated airway epithelial cells obtained by nasal scraping from CF patients and healthy controls. Ex vivo epithelium grew successfully in ALI cultures with significant rise in the expression of CFTR and of markers of airway epithelial differentiation compared to monolayer cell culture. SAHA decreased CFTR transcript and protein levels in CF and non-CF epithelia. Whereas SAHA induced lysine hyperacetylation, it did not change histone modifications at the CFTR promoter. SAHA reduced MUC5AC and MUC5B expression and inhibited goblet epithelial cell differentiation. Similar effects were obtained in CF and non-CF epithelia. All the effects were fully reversible within five days from SAHA withdrawal. We conclude that, ex vivo, SAHA modulate the structure of airway epithelia without specific effect on CFTR gene and protein suggesting that HDACi cannot be useful for CF treatment. Copyright © 2017. Published by Elsevier Ltd.

SAHA-induced TRAIL-sensitisation of Multiple Myeloma cells is enhanced in 3D cell culture.

Science.gov (United States)

Arhoma, A; Chantry, A D; Haywood-Small, S L; Cross, N A

2017-11-15

Multiple Myeloma (MM) is currently incurable despite many novel therapies. Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) is a potential anti-tumour agent although effects as a single agent are limited. In this study, we investigated whether the Histone Deacetylase (HDAC) inhibitor SAHA can enhance TRAIL-induced apoptosis and target TRAIL resistance in both suspension culture, and 3D cell culture as a model of disseminated MM lesions that form in bone. The effects of SAHA and/or TRAIL in 6 Multiple Myeloma cell lines were assessed in both suspension cultures and in an Alginate-based 3D cell culture model. The effect of SAHA and/or TRAIL was assessed on apoptosis by assessment of nuclear morphology using Hoechst 33342/Propidium Iodide staining. Viable cell number was assessed by CellTiter-Glo luminescence assay, Caspase-8 and -9 activities were measured by Caspase-Glo™ assay kit. TRAIL-resistant cells were generated by culture of RPMI 8226 and NCI-H929 by acute exposure to TRAIL followed by selection of TRAIL-resistant cells. TRAIL significantly induced apoptosis in a dose-dependent manner in OPM-2, RPMI 8226, NCI-H929, U266, JJN-3 MM cell lines and ADC-1 plasma cell leukaemia cells. SAHA amplified TRAIL responses in all lines except OPM-2, and enhanced TRAIL responses were both via Caspase-8 and -9. SAHA treatment induced growth inhibition that further increased in the combination treatment with TRAIL in MM cells. The co-treatment of TRAIL and SAHA reduced viable cell numbers all cell lines. TRAIL responses were further potentiated by SAHA in 3D cell culture in NCI-H929, RPMI 8226 and U266 at lower TRAIL + SAHA doses than in suspension culture. However TRAIL responses in cells that had been selected for TRAIL resistance were not further enhanced by SAHA treatment. SAHA is a potent sensitizer of TRAIL responses in both TRAIL sensitive and resistant cell lines, in both suspension and 3D culture, however SAHA did not sensitise TRAIL-sensitive cell

Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability

International Nuclear Information System (INIS)

Zhang, Jingjie; Ouyang, Weiming; Li, Jingxia; Zhang, Dongyun; Yu, Yonghui; Wang, York; Li, Xuejun; Huang, Chuanshu

2012-01-01

Suberoylanilide hydroxamic acid (SAHA) inhibiting cancer cell growth has been associated with its downregulation of cyclin D1 protein expression at transcription level or translation level. Here, we have demonstrated that SAHA inhibited EGF-induced Cl41 cell transformation via the decrease of cyclin D1 mRNA stability and induction of G0/G1 growth arrest. We found that SAHA treatment resulted in the dramatic inhibition of EGF-induced cell transformation, cyclin D1 protein expression and induction of G0/G1 growth arrest. Further studies showed that SAHA downregulation of cyclin D1 was only observed with endogenous cyclin D1, but not with reconstitutionally expressed cyclin D1 in the same cells, excluding the possibility of SAHA regulating cyclin D1 at level of protein degradation. Moreover, SAHA inhibited EGF-induced cyclin d1 mRNA level, whereas it did not show any inhibitory effect on cyclin D1 promoter-driven luciferase reporter activity under the same experimental conditions, suggesting that SAHA may decrease cyclin D1 mRNA stability. This notion was supported by the results that treatment of cells with SAHA decreased the half-life of cyclin D1 mRNA from 6.95 h to 2.57 h. Consistent with downregulation of cyclin D1 mRNA stability, SAHA treatment also attenuated HuR expression, which has been well-characterized as a positive regulator of cyclin D1 mRNA stability. Thus, our study identifies a novel mechanism responsible for SAHA inhibiting cell transformation via decreasing cyclin D1 mRNA stability and induction of G0/G1 growth arrest in Cl41 cells. -- Highlights: ► SAHA inhibits cell transformation in Cl41 cells. ► SAHA suppresses Cyclin D1 protein expression. ► SAHA decreases cyclin D1 mRNA stability.

Inhibition of multiple pathogenic pathways by histone deacetylase inhibitor SAHA in a corneal alkali-burn injury model

Science.gov (United States)

Li, Xinyu; Zhou, Qinbo; Hanus, Jakub; Anderson, Chastain; Zhang, Hongmei; Dellinger, Michael; Brekken, Rolf; Wang, Shusheng

2013-01-01

Neovascularization (NV) in the cornea is a major cause of vision impairment and corneal blindness. Hemangiogenesis and lymphangiogenesis induced by inflammation underlie the pathogenesis of corneal NV. The current mainstay treatment, corticosteroid, treats the inflammation associated with corneal NV, but is not satisfactory due to such side effects as cataract and the increase in intraocular pressure. It is imperative to develop a novel therapy that specifically targets the hemangiogenesis, lymphangiogenesis and inflammation pathways underlying corneal NV. Histone deacetylase inhibitors (HDACi) have been in clinical trials for cancer and other diseases. In particular, HDACi suberoylanilide hydroxamic acid (SAHA, vorinostat, Zolinza) has been approved by the FDA for the treatment of cutaneous T-cell lymphoma. The functional mechanism of SAHA in cancer and especially in corneal NV remains unclear. Here, we show that topical application of SAHA inhibits neovascularization in an alkali-burn corneal injury model. Mechanistically, SAHA inhibits corneal NV by repressing hemangiogenesis, inflammation pathways and previously overlooked lymphangiogenesis. Topical SAHA is well tolerated on the ocular surface. In addition, the potency of SAHA in corneal NV appears to be comparable to the current steroid therapy. SAHA may possess promising therapeutic potential in alkali-burn corneal injury and other inflammatory neovascularization disorders. PMID:23186311

“Hare Krishna vs. Shiva Shiva”: Swami Agehananda Bharati, Drugs, and the Mystical State in Hindusim

Directory of Open Access Journals (Sweden)

Helton Christopher Jason

2016-12-01

Full Text Available This paper will form an overview of Swami Agehananda Bharati’s views about drugs as a catalyst for achieving the mystical state (in both a Hindu and general context, as well as his observations of the perception of drugs throughout the Hindu community, inside and outside South Asia. It will demonstrate that Bharati considered drugs a valid means toward achieving the mystical state, both as a scholar of Hinduism and as a practicing sannyasin.

Up-Regulation of P21 Inhibits TRAIL-Mediated Extrinsic Apoptosis, Contributing Resistance to SAHA in Acute Myeloid Leukemia Cells

Directory of Open Access Journals (Sweden)

Xing Wu

2014-08-01

Full Text Available Background/Aim: P21, a multifunctional cell cycle-regulatory molecule, regulates apoptotic cell death. In this study we examined the effect of altered p21 expression on the sensitivity of acute myeloid leukemia cells in response to HDAC inhibitor SAHA treatment and investigated the underlying mechanism. Methods: Stably transfected HL60 cell lines were established in RPMI-1640 with supplementation of G-418. Cell viability was measured by MTT assay. Western blot was applied to assess the protein expression levels of target genes. Cell apoptosis was monitored by AnnexinV-PE/7AAD assay. Results: We showed HL60 cells that that didn't up-regulate p21 expression were more sensitive to SAHA-mediated apoptosis than NB4 and U937 cells that had increased p21 level. Enforced expression of p21 in HL60 cells reduced sensitivity to SAHA and blocked TRAIL-mediated apoptosis. Conversely, p21 silencing in NB4 cells enhanced SAHA-mediated apoptosis and lethality. Finally, we found that combined treatment with SAHA and rapamycin down-regulated p21 and enhanced apoptosis in AML cells. Conclusion: We conclude that up-regulated p21 expression mediates resistance to SAHA via inhibition of TRAIL apoptotic pathway. P21 may serve as a candidate biomarker to predict responsiveness or resistance to SAHA-based therapy in AML patients. In addition, rapamycin may be an effective agent to override p21-mediated resistance to SAHA in AML patients.

Approximate solution of the Saha equation - temperature as an explicit function of particle densities

International Nuclear Information System (INIS)

Sato, M.

1991-01-01

The Saha equation for a plasma in thermodynamic equilibrium (TE) is approximately solved to give the temperature as an explicit function of population densities. It is shown that the derived expressions for the Saha temperature are valid approximations to the exact solution. An application of the approximate temperature to the calculation of TE plasma parameters is also described. (orig.)

EFFECTS OF HISTONE DEACETYLASE INHIBITOR, SAHA, ON EFFECTOR AND FOXP3+ REGULATORY T CELLS IN RHESUS MACAQUES

Science.gov (United States)

Johnson, Jennifer; Pahuja, Anil; Graham, Melanie; Hering, Bernhard; Hancock, Wayne W.; Pratima, Bansal-Pakala

2008-01-01

SAHA, a histone deacetylase inhibitor (HDACi), is clinically approved for treatment of cutaneous T-cell lymphoma. Although the exact underlying mechanisms are unknown, HDACi arrest the cell cycle in rapidly proliferating tumor cells and promote their apoptosis. HDACi were also recently shown to enhance the production and suppressive functions of Foxp3+ regulatory T (Treg) cells in rodents, leading us to begin to investigate the actions of HDACi on rhesus monkey T cells for the sake of potential preclinical applications. In this study, we show that SAHA inhibits polyclonal activation and proliferation of rhesus T cells and that the anti-proliferative effects are due to inhibition of T effector (Teff) cells and enhancement of Treg cells. Cryopreserved rhesus macaque splenocytes were CFSE labeled, stimulated with anti-CD3/anti-CD28 and cultured for 5 days in the presence of varying concentrations of SAHA. Samples were then co-stained to evaluate CD4 and CD8 expression. 10 and 5μM concentrations of SAHA were toxic to splenocytes. Proliferation was inhibited by 57% in CD4 cells and 47% in CD8 cells when unseparated splenocytes were cultured with 3 μM SAHA. Effector cells alone showed a decreased inhibition to proliferation when cultured with 3 μM and 1 μM SAHA when compared to Teff plus Treg cells. Our data suggest that SAHA can be used as part of an immunosuppressive protocol to enhance graft survival by limiting Teff cell proliferation as well as increasing Treg cells, thereby promoting tolerance. PMID:18374101

SCADA Sistemi ile Bir İşletmenin Dış Saha Otomasyonu

OpenAIRE

Kılıç, Murat; Özdemir, Şule

2010-01-01

Bu çalışmada, PLC (Programmable Logic Controller: Programlanabilir Mantık Denetleyici) ve SCADA (Supervising Control and Data Acquisition: Veri Tabanlı Kontrol ve Gözetleme) sistemleriyle bir MDF (Medium Density Fiberboard) presi dış saha besleme hattının otomasyonu gerçekleştirilmiştir. Tüm sistem SCADA sayesinde bilgisayar ekranından izlenebilmekte ve kontrol edilebilmektedir. MDF presi dış saha besleme hattı tam otomasyon ile çalışmaktadır. Otomasyon sisteminde PLC yazılımı olarak Siemens ...

Meghnad Saha his life in science and politics

CERN Document Server

Naik, Pramod V

2017-01-01

This biography is a short yet comprehensive overview of the life of Meghnad Saha, the mastermind behind the frequently used Saha equations and a strong contributor to the foundation of science in India. The author explores the lesser known details behind the man who played a major role in building scientific institutions in India, developed the breakthrough theory of thermal ionization, and whose fervor about India’s rapid progress in science and technology, along with concern for uplifting his countrymen and optimizing resources, led him to eventually enter politics and identify the mismanagement of many programs of national importance to Parliament. This book is free of most academic technicalities, so that the reader with general scientific knowledge can read and understand it easily. One interested only in Saha’s contribution to physics can pick up just that part and read it. Conversely, the average reader may skip the technical chapters, and read the book without loss of continuity or generality to s...

Radiosensitization by SAHA in Experimental Colorectal Carcinoma Models-In Vivo Effects and Relevance of Histone Acetylation Status

International Nuclear Information System (INIS)

Folkvord, Sigurd; Ree, Anne Hansen; Furre, Torbjorn; Halvorsen, Thomas; Flatmark, Kjersti

2009-01-01

Purpose: Histone deacetylase inhibitors are being evaluated as antitumor agents in ongoing clinical trials, and promising preclinical results, combined with favorable toxicity profiles, have rendered the drugs as interesting candidates for combination with other treatment modalities, such as radiotherapy. The aim of the present study was to evaluate the radiosensitizing properties of suberoylanilide hydroxamic acid (SAHA) and the possible requirement of histone hyperacetylation at radiation exposure. Methods and materials: Radiosensitization by SAHA was assessed in a colorectal carcinoma cell line and in two colorectal xenograft models by analysis of clonogenic survival and tumor growth delay, respectively. Histone acetylation status at radiation exposure was evaluated by Western blot. Results: In vitro, radiosensitization was demonstrated when cells were preincubated with SAHA, and, in the xenografts, tumor growth was delayed when the mice were treated with fractionated radiation combined with daily SAHA injections compared with radiation alone. Surprisingly, the SAHA-dependent growth delay was still present when radiation was delivered at restored baseline acetylation levels compared with maximal histone hyperacetylation. Conclusion: SAHA was an effective radiosensitizer in experimental colorectal carcinoma models, suggesting that histone deacetylase inhibition might constitute a valuable supplement to current multimodal treatment strategies in rectal cancer. The presence of histone hyperacetylation at radiation was not required to obtain an increased radiation response, questioning the validity of using histone hyperacetylation as a molecular marker for radiosensitivity.

Opacity calculations and Saha's equation for high Z elements

International Nuclear Information System (INIS)

Godwal, B.K.; Sikka, S.K.

1977-01-01

Opacity calculations are needed for energy transport by radiation for high Z element plasmas as these have been suggested as temper materials in laser, electron beam and heavy ion fusion schemes. The pressure ionised modified form of Saha's ionisation equation has been used to obtain the free electron density, populations of various ionic species and the populations of various energy states for a given ion. Results are presented for two typical elements; tungsten and uranium. The ionisation potential have been evaluated using the Bohr's formula with suitable effective screened charges for ions. The results show that for uranium, even at a temperature of 10 kev, the K shell is intact. The reliability of the Saha's equation solution has been checked by comparing the equation of state (total pressure vs total energy curve) with that given by the Thomas-Fermi-Dirac equation of state. The agreement between the two is good from temperature upwards of 0.2 kev. (author)

SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease.

Directory of Open Access Journals (Sweden)

Michal Mielcarek

Full Text Available Huntington's disease (HD is a progressive neurological disorder for which there are no disease-modifying treatments. Transcriptional dysregulation is a major molecular feature of HD, which significantly contributes to disease progression. Therefore, the development of histone deacetylase (HDAC inhibitors as therapeutics for HD has been energetically pursued. Suberoylanilide hydroxamic acid (SAHA - a class I HDAC as well an HDAC6 inhibitor, improved motor impairment in the R6/2 mouse model of HD. Recently it has been found that SAHA can also promote the degradation of HDAC4 and possibly other class IIa HDACs at the protein level in various cancer cell lines. To elucidate whether SAHA is a potent modifier of HDAC protein levels in vivo, we performed two independent mouse trials. Both WT and R6/2 mice were chronically treated with SAHA and vehicle. We found that prolonged SAHA treatment causes the degradation of HDAC4 in cortex and brain stem, but not hippocampus, without affecting its transcript levels in vivo. Similarly, SAHA also decreased HDAC2 levels without modifying the expression of its mRNA. Consistent with our previous data, SAHA treatment diminishes Hdac7 transcript levels in both wild type and R6/2 brains and unexpectedly was found to decrease Hdac11 in R6/2 but not wild type. We investigated the effects of SAHA administration on well-characterised molecular readouts of disease progression. We found that SAHA reduces SDS-insoluble aggregate load in the cortex and brain stem but not in the hippocampus of the R6/2 brains, and that this was accompanied by restoration of Bdnf cortical transcript levels.

Some considerations regarding the applicability of the Saha-Eggert equation to quantitative SIMS analysis

International Nuclear Information System (INIS)

Werner, H.W.; Morgan, A.E.

1978-01-01

Some thoughts are presented on the physical processes described by the Saha-Eggert equation and some estimates are made regarding equilibration in a spike generated by ion bombardment. The influence of different parameters on the temperature determined from the Saha-Eggert equation is discussed. Section headings are: ionization in a spike; equilibration in a spike; factors influencing the ionization temperature (primary ion energy, secondary ion energies, presence of oxygen (an example shows the ionization temperature for uranium as a function of secondary ion energies and bombarding conditions)). (U.K.)

Design, Synthesis and Biological Evaluation of Histone Deacetylase (HDAC) Inhibitors: Saha (Vorinostat) Analogs and Biaryl Indolyl Benzamide Inhibitors Display Isoform Selectivity

Science.gov (United States)

Negmeldin, Ahmed Thabet

HDAC proteins have emerged as interesting targets for anti-cancer drugs due to their involvement in cancers, as well as several other diseases. Several HDAC inhibitors have been approved by the FDA as anti-cancer drugs, including SAHA (suberoylanilide hydroxamic acid, Vorinostat). Unfortunately, SAHA inhibits most HDAC isoforms, which limit its use as a pharmacological tool and may lead to side effects in the clinic. In this work we were interested in developing isoform selective HDAC inhibitors, which may decrease or eliminate the side effects associated with non-selective inhibitors treatment. In addition, isoform selective HDAC inhibitors can be used as biological tools to help understand the HDAC-related cancer biology. Our strategy was based on synthesis and screening of several derivatives of the non-selective FDA approved drug SAHA substituted at different positions of the linker region. Several SAHA analogs modified at the C4 and C5 positions of the linker were synthesized. The new C4- and C5-modified SAHA libraries, along with the previously synthesized C2-modified SAHA analogs were screened in vitro and in cellulo for HDAC isoform selectivity. Interestingly, several analogs exhibited dual HDAC6/HDAC8 selectivity. Enantioselective syntheses of the pure enantiomers of some of the interesting analogs were performed and the enantiomers were screened in vitro. Among the most interesting analogs, ( R)-C4-benzyl SAHA displayed 520- to 1300-fold selectivity for HDAC6 and HDAC8 over HDAC1, 2, and 3, with IC50 values of 48 and 27 nM with HDAC6 and 8, respectively. Docking studies were performed to provide structural rationale for the observed selectivity of the new analogs. In addition, rational design, synthesis, and screening of several other biaryl indolyl benzamide HDAC inhibitors is discussed, and some showed modest HDAC1 selectivity. The new biaryl indolyl benzamides can be useful to further develop HDAC1 selective inhibitors. The dual HDAC6/8 selective

Quantum degeneracy corrections to plasma line emission and to Saha equation

International Nuclear Information System (INIS)

Molinari, V.G.; Mostacci, D.; Rocchi, F.; Sumini, M.

2003-01-01

The effect of quantum degeneracy on the electron collisional excitation is investigated, and its effects on line emission evaluated for applications to spectroscopy of dense, cold plasmas. A correction to Saha equation for weakly-degenerate plasmas is also presented

Evolution of nuclear spectroscopy at Saha Institute of Nuclear Physics

Indian Academy of Sciences (India)

1990 to date a variety of medium energy heavy ions were made available from the BARC-TIFR Pel- letron and the Nuclear Science Centre Pelletron. The state of the art gamma detector arrays in these centres enabled the Saha Institute groups to undertake more sophisticated experiments. Front line nuclear spectroscopy ...

Evolution of nuclear spectroscopy at Saha Institute of Nuclear Physics

Indian Academy of Sciences (India)

Currently Saha Institute is building a multi-element gamma heavy ion neutron array detector (MEGHNAD), which will have six high efficiency clover Ge detector together with charged particle ball and other accessories. The system is expected to be usable in 2002 and will be used in experiments using high energy heavy ...

Nuclear structure studies at Saha Institute of Nuclear Physics using ...

Indian Academy of Sciences (India)

In-beam gamma-ray spectroscopy, carried out at the Saha Institute of Nuclear Physics in the recent past, using heavy-ion projectiles from the pelletron accelerator centres in the country and multi-detector arrays have yielded significant data on the structure of a large number of nuclei spanning different mass regions.

Saha and temperature relaxation approximations for the study of ionization instability in partially ionized plasma

International Nuclear Information System (INIS)

Numano, M.

1976-01-01

The growth rates for the ionization instability obtained using the Saha and temperature relaxation approximations are compared with those obtained from an exact treatment, and the requirements for validity of these two approximations are obtained analytically. For the range of plasma parameters pertinent to MHD power generation it is found that the Saha approximation is valid for relatively high electron temperature, which it becomes inapplicable as the electron temperature is decreased. On the other hand, the temperature relaxation approximation is accurate over a wide range of electron temperature. It is found also that the marginal condition for the ionization instability is correctly obtained from both approximations. (author)

Epigenetic silencing of apoptosis-inducing gene expression can be efficiently overcome by combined SAHA and TRAIL treatment in uterine sarcoma cells.

Directory of Open Access Journals (Sweden)

Leopold F Fröhlich

Full Text Available The lack of knowledge about molecular pathology of uterine sarcomas with a representation of 3-7% of all malignant uterine tumors prevents the establishment of effective therapy protocols. Here, we explored advanced therapeutic options to the previously discovered antitumorigenic effects of the histone deacetylase (HDAC inhibitor suberoylanilide hydroxamic acid (SAHA by combined treatment with the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo-2L. In addition, we investigated the uterine sarcoma cell lines, MES-SA and ESS-1, regarding the underlying molecular mechanisms of SAHA and TRAIL-induced apoptosis and their resistance towards TRAIL. Compared to single SAHA or TRAIL treatment, the combination of SAHA with TRAIL led to complete cell death of both tumor cell lines after 24 to 48 hours. In contrast to single SAHA treatment, apoptosis occured faster and was more pronounced in ESS-1 cells than in MES-SA cells. Induction of SAHA- and TRAIL-induced apoptosis was accompanied by upregulation of the intrinsic apoptotic pathway via reduction of mitochondrial membrane potential, caspase-3, -6, and -7 activation, and PARP cleavage, but was also found to be partially caspase-independent. Apoptosis resistance was caused by reduced expression of caspase-8 and DR 4/TRAIL-R1 in ESS-1 and MES-SA cells, respectively, due to epigenetic silencing by DNA hypermethylation of gene promoter sequences. Treatment with the demethylating agent 5-Aza-2'-deoxycytidine or gene transfer therefore restored gene expression and increased the sensitivity of both cell lines against TRAIL-induced apoptosis. Our data provide evidence that deregulation of epigenetic silencing by histone acetylation and DNA hypermethylation might play a fundamental role in the origin of uterine sarcomas. Therefore, tumor growth might be efficiently overcome by a cytotoxic combinatorial treatment of HDAC inhibitors with TRAIL.

Thermodynamic inconsistency of the modified Saha equation at high pressures

International Nuclear Information System (INIS)

Sweeney, M.A.

1978-01-01

The inclusion of a pressure ionization term in the Saha equation violates the thermodynamic Maxwell identities if corresponding changes are not made to the expressions for entropy and pressure. It is demonstrated that the usual application of the Rouse and Stewart-Pyatt modesl suffers from this limitation. Negative values of the adiabatic gradient in the degenerate dwarf models of Boehm and Straka are explained in terms of this thermodynamic inconsistency

Thermodynamic derivation of Saha's equation for a multi-temperature plasma

International Nuclear Information System (INIS)

Morro, Angelo; Romeo, Maurizio

1988-01-01

The ionization equilibrium between the constituents of a multi-temperature plasma is investigated within the thermodynamics of fluid mixtures. As a result, a law of mass action is derived that, in the approximation of ideal gases for the constituents, leads to a direct generalization of Saha's equation. The main properties of this generalization are discussed, and contrasted with those of other equations which have appeared in the literature. (author)

A Hartree-Fock-Slater-Boltzmann-Saha method for detailed atomic structure and equation of state of plasmas

International Nuclear Information System (INIS)

Jiang Minhao; Meng Xujun

2005-01-01

The effect of the free electron background in plasmas is introduced in Hartree-Fock-Slater self-consistent field atomic model to correct the single electron energies for each electron configuration, and to provide accurate atomic data for Boltzmann-Saha equation. In the iteration process chemical potential is adjusted to change the free electron background to satisfy simultaneously the conservation of the free electrons in Saha equation as well as in Hartree-Fock-Slater self-consistent field atomic model. As examples the equations of state of the carbon and aluminum plasmas are calculated to show the applicability of this method. (authors)

Quantitative evaluation of SIMS spectra including spectrum interpretation and Saha-Eggert correction

International Nuclear Information System (INIS)

Steiger, W.; Ruedenauer, F.G.

1978-01-01

A spectrum identification program is described, using a computer algorithm which solely relies on the natural isotopic abundances for identification of elemental, molecular and cluster ions. The thermodynamic approach to the quantitative interpretation of SIMS spectra, through the use of the Saha-Eggert equation, is discussed, and a computer program is outlined. (U.K.)

SAHA (Vorinostat Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABAA Receptor γ2 Subunit

Directory of Open Access Journals (Sweden)

Nela Durisic

2018-03-01

Full Text Available The GABAA receptor (GABAAR α1 subunit A295D epilepsy mutation reduces the surface expression of α1A295Dβ2γ2 GABAARs via ER-associated protein degradation. Suberanilohydroxamic acid (SAHA, also known as Vorinostat was recently shown to correct the misfolding of α1A295D subunits and thereby enhance the functional surface expression of α1A295Dβ2γ2 GABAARs. Here we investigated whether SAHA can also restore the surface expression of γ2 GABAAR subunits that incorporate epilepsy mutations (N40S, R43Q, P44S, R138G known to reduce surface expression via ER-associated protein degradation. As a control, we also investigated the γ2K289M epilepsy mutation that impairs gating without reducing surface expression. Effects of mutations were evaluated on inhibitory postsynaptic currents (IPSCs mediated by the major synaptic α1β2γ2 GABAAR isoform. Recordings were performed in neuron-HEK293 cell artificial synapses to minimise contamination by GABAARs of undefined subunit composition. Transfection with α1β2γ2N40S, α1β2γ2R43Q, α1β2γ2P44S and α1β2γ2R138G subunits produced IPSCs with decay times slower than those of unmutated α1β2γ2 GABAARs due to the low expression of mutant γ2 subunits and the correspondingly high expression of slow-decaying α1β2 GABAARs. SAHA pre-treatment significantly accelerated the decay time constants of IPSCs consistent with the upregulation of mutant γ2 subunit expression. This increase in surface expression was confirmed by immunohistochemistry. SAHA had no effect on either the IPSC kinetics or surface expression levels of α1β2γ2K289M GABAARs, confirming its specificity for ER-retained mutant γ2 subunits. We also found that α1β2γ2K289M GABAARs and SAHA-treated α1β2γ2R43Q, α1β2γ2P44S and α1β2γ2R138G GABAARs all mediated IPSCs that decayed at significantly faster rates than wild type receptors as temperature was increased from 22 to 40°C. This may help explain why these mutations cause febrile

Ovarian SAHA syndrome is associated with a more insulin-resistant profile and represents an independent risk factor for glucose abnormalities in women with polycystic ovary syndrome: a prospective controlled study.

Science.gov (United States)

Dalamaga, Maria; Papadavid, Evangelia; Basios, Georgios; Vaggopoulos, Vassilios; Rigopoulos, Dimitrios; Kassanos, Dimitrios; Trakakis, Eftihios

2013-12-01

SAHA syndrome is characterized by the tetrad: seborrhea, acne, hirsutism, and androgenetic alopecia. No previous study has examined the prevalence of glucose abnormalities in ovarian SAHA and explored whether it may be an independent risk factor for glucose abnormalities. In a prospective controlled study, we investigated the spectrum of glucose abnormalities in ovarian SAHA and explored whether it is associated with a more insulin-resistant profile. In all, 316 patients with a diagnosis of polycystic ovary syndrome (PCOS) (56 with SAHA) and 102 age-matched healthy women were examined and underwent a 2-hour oral glucose tolerance test. Serum glucose homeostasis parameters, hormones, and adipokines were determined. SAHA prevalence was 17.7% in patients with PCOS and predominance of the severe PCOS phenotype. Ovarian SAHA was independently associated with a more insulin-resistant profile (higher homeostatic model assessment of insulin resistance score, lower quantitative insulin sensitivity check index [QUICKI] and MATSUDA indices, and relative hypoadiponectinemia), and represented an independent risk factor for glucose abnormalities regardless of anthropometric features, age, and PCOS phenotype. There was no performance of skin biopsies. The prompt recognition of SAHA syndrome in women with PCOS permits an earlier diagnosis and surveillance of metabolic abnormalities, especially in Mediterranean PCOS population exhibiting a lower prevalence of glucose abnormalities. Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

Extended use of a computation method for electrical conductivity-case of non-Saha-equilibrium plasmas

International Nuclear Information System (INIS)

Chen, R.L.W.

1981-01-01

The use of an equation obtained earlier for computing electrical conductivity may be extended to partially ionized gases which depart from the Saha equation, provided the electron velocity distributions do not deviate from the Maxwellian distribution. (author)

The anti-tumor histone deacetylase inhibitor SAHA and the natural flavonoid curcumin exhibit synergistic neuroprotection against amyloid-beta toxicity.

Directory of Open Access Journals (Sweden)

Jia Meng

Full Text Available With the trend of an increasing aged population worldwide, Alzheimer's disease (AD, an age-related neurodegenerative disorder, as one of the major causes of dementia in elderly people is of growing concern. Despite the many hard efforts attempted during the past several decades in trying to elucidate the pathological mechanisms underlying AD and putting forward potential therapeutic strategies, there is still a lack of effective treatments for AD. The efficacy of many potential therapeutic drugs for AD is of main concern in clinical practice. For example, large bodies of evidence show that the anti-tumor histone deacetylase (HDAC inhibitor, suberoylanilidehydroxamic acid (SAHA, may be of benefit for the treatment of AD; however, its extensive inhibition of HDACs makes it a poor therapeutic. Moreover, the natural flavonoid, curcumin, may also have a potential therapeutic benefit against AD; however, it is plagued by low bioavailability. Therefore, the integrative effects of SAHA and curcumin were investigated as a protection against amyloid-beta neurotoxicity in vitro. We hypothesized that at low doses their synergistic effect would improve therapeutic selectivity, based on experiments that showed that at low concentrations SAHA and curcumin could provide comprehensive protection against Aβ25-35-induced neuronal damage in PC12 cells, strongly implying potent synergism. Furthermore, network analysis suggested that the possible mechanism underlying their synergistic action might be derived from restoration of the damaged functional link between Akt and the CBP/p300 pathway, which plays a crucial role in the pathological development of AD. Thus, our findings provided a feasible avenue for the application of a synergistic drug combination, SAHA and curcumin, in the treatment of AD.

Kinetic and Thermodynamic Rationale for SAHA Being a Preferential Human HDAC8 Inhibitor as Compared to the Structurally Similar Ligand, TSA

Science.gov (United States)

Singh, Raushan K.; Lall, Naveena; Leedahl, Travis S.; McGillivray, Abigail; Mandal, Tanmay; Haldar, Manas; Mallik, Sanku; Cook, Gregory; Srivastava, D.K.

2013-01-01

Of the different hydroxamate-based histone deacetylase (HDAC) inhibitors, Suberoylanilide hydroxamic acid (SAHA) has been approved by the FDA for treatment of T-cell lymphoma. Interestingly, a structurally similar inhibitor, Trichostatin A (TSA), which has a higher in vitro inhibitory-potency against HDAC8, reportedly shows a poor efficacy in clinical settings. In order to gain the molecular insight into the above discriminatory feature, we performed transient kinetic and isothermal titration calorimetric studies for the interaction of SAHA and TSA to the recombinant form of human HDAC8. The transient kinetic data revealed that the binding of both the inhibitors to the enzyme showed the biphasic profiles, which represented an initial encounter of enzyme with the inhibitor followed by the isomerization of the transient enzyme-inhibitor complexes. The temperature-dependent transient kinetic studies with the above inhibitors revealed that the bimolecular process is primarily dominated by favorable enthalpic changes, as opposed to the isomerization step; which is solely contributed by entropic changes. The standard binding-enthalpy (ΔH0) of SAHA, deduced from the transient kinetic as well as the isothermal titration calorimetric experiments, was 2–3 kcal/mol higher as compared to TSA. The experimental data presented herein suggests that SAHA serves as a preferential (target-specific/selective) HDAC8 inhibitor as compared to TSA. Arguments are presented that the detailed kinetic and thermodynamic studies may guide in the rational design of HDAC inhibitors as therapeutic agents. PMID:24079912

Nonuniqueness of two-temperature Guldberg-Waage and Saha equations: Influence on thermophysical properties of SF6 plasmas

International Nuclear Information System (INIS)

Wang, Weizong; Rong, Mingzhe; Spencer, Joseph W.

2013-01-01

This paper focuses to study how the choice of Guldberg-Waage and Saha equations affects the thermodynamic properties and transport coefficients of SF 6 plasmas under both thermal equilibrium and non-equilibrium conditions. The species composition is numerically determined using two typical forms of two-temperature Saha equations and Guldberg-Waage equations that have appeared in the literature. The great influence of the choice of the excitation temperature on the plasma composition and hence the thermodynamic properties and transport coefficients is discussed as well. Transport coefficients are calculated with most recent collision interaction potentials by adopting Devoto's electron and heavy particle decoupling approach but expanded to the third-order approximation (second-order for viscosity) within the framework of Chapman-Enskog method. Furthermore, an analysis of the effect of different definitions of Debye length on the properties values was performed as well. The results are computed for various values of pressures from 0.10 atm to 10 atm and non-equilibrium parameter, i.e., ratio of the electron temperature to the heavy particle temperature from 1 to 5 with electron temperature range from 300 to 40 000 K. Both forms of Guldberg-Waage and Saha equations used here can give completely the same value when the two-temperature model reaches the special case of local thermodynamic equilibrium. It has been observed that all above mentioned factors can significantly modify the plasma species composition and consequently affect the thermodynamic and transport properties

Iron complexation to histone deacetylase inhibitors SAHA and LAQ824 in PEGylated liposomes can considerably improve pharmacokinetics in rats.

Science.gov (United States)

Wang, Yan; Tu, Sheng; Steffen, Dana; Xiong, May

2014-01-01

The formulation of histone deacetylase inhibitors (HDACi) is challenging due to poor water solubility and rapid elimination of drugs in vivo. This study investigated the effects of complexing iron (Fe3+) to the HDACi suberoylanilide hydroxamic acid (SAHA) and LAQ824 (LAQ) prior to their encapsulation into PEGylated liposomes, and investigated whether this technique could improve drug solubility, in vitro release and in vivo pharmacokinetic (PK) properties. METHODS. The reaction stoichiometry, binding constants and solubility were measured for Fe complexes of SAHA and LAQ. The complexes were passively encapsulated into PEGylated liposomes and characterized by size distribution, zeta-potential, encapsulation efficiency (EE), and in vitro drug release studies. PC-3 cells were used to verify the in vitro anticancer activity of the formulations. In vivo pharmacokinetic properties of liposomal LAQ-Fe (L-LAQ-Fe) was evaluated in rats. RESULTS. SAHA and LAQ form complexes with Fe at 1:1 stoichiometric ratio, with a binding constant on the order of 104 M-1. Fe complexation improved the aqueous solubility and the liposomal encapsulation efficiency of SAHA and LAQ (29-35% EE, final drug concentration > 1 mM). Liposomal encapsulated complexes (L-HDACi-Fe) exhibited sustained in vitro release properties compared to L-HDACi but cytotoxicity on PC-3 cells was comparable to free drugs. The PK of L-LAQ-Fe revealed 15-fold improvement in the plasma t1/2 (12.11 h)and 211-fold improvement in the AUC∞ (105.7 µg·h/ml) compared to free LAQ (0.79 h, 0.5 µg·h/ml). Similarly, the plasma t1/2 of Fe was determined to be 11.83 h in a separate experiment using radioactive Fe-59. The majority of Fe-59 activity was found in liver and spleen of rats and correlates with liposomal uptake by the mononuclear phagocyte system. CONCLUSIONS. We have demonstrated that encapsulation of Fe complexes of HDACi into PEGylated liposomes can improve overall drug aqueous solubility, in vitro release and in

Nonuniqueness of the two-temperature Saha equation and related considerations

International Nuclear Information System (INIS)

Giordano, D.; Capitelli, M.

2002-01-01

The present paper contains considerations relative to the long debated thermodynamic derivation of two-temperature Saha equations. The main focus of our discourse is on the dependence of the multitemperature equilibrium conditions on the constraints imposed on the thermodynamic system. We also examine the following key issues related to that dependence: correspondence between constraints and equilibrium-equation forms that have appeared in the literature; presumed dominance of the free-electron translational temperature in the two-temperature expression of the equilibrium constant of the ionization reaction A A + +e - ; disagreement between the derivation methods based on, respectively, the extended second law of classical thermodynamics and axiomatic thermodynamics; and plausibility of the existence of entropic constraints

Synergistic anticancer effects of cisplatin and histone deacetylase inhibitors (SAHA and TSA) on cholangiocarcinoma cell lines.

Science.gov (United States)

Asgar, Md Ali; Senawong, Gulsiri; Sripa, Banchob; Senawong, Thanaset

2016-01-01

Clinical application of cisplatin against cholangiocarcinoma is often associated with resistance and toxicity posing urgent demand for combination therapy. In this study, we evaluated the combined anticancer effect of cisplatin and histone deacetylase inhibitors (HDACIs), suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA), on the cholangiocarcinoma KKU-100 and KKU-M214 cell lines. Antiproliferative activity was evaluated using MTT assay. Apoptosis induction and cell cycle arrest were analyzed by flow cytometry. Cell cycle and apoptosis regulating proteins were evaluated by western blot analysis. MTT assay showed that cisplatin, SAHA and TSA dose-dependently reduced the viability of KKU-100 and KKU-M214 cells. The combination of cisplatin and HDACIs exerted significantly more cytotoxicity than the single drugs. Combination indices below 1.0 reflect synergism between cisplatin and HDACIs, leading to positive dose reductions of cisplatin and HDACIs. Cisplatin and HDACIs alone induced G0/G1 phase arrest in KKU-100 cells, but the drug combinations increased sub-G1 percent more than either drug. However, cisplatin and HDACIs alone or in combination increased only the sub-G1 percent in KKU-M214 cells. Annexin V-FITC staining revealed that cisplatin and HDACIs combinations induced more apoptotic cell death of both KKU-100 and KKU-M214 cells than the single drug. In KKU-100 cells, growth inhibition was accompanied by upregulation of p53 and p21 and downregulation of CDK4 and Bcl-2 due to exposure to cisplatin, SAHA and TSA alone or in combination. Moreover, combination of agents exerted higher impacts on protein expression. Single agents or combination did not affect p53 expression, however, combination of cisplatin and HDACIs increased the expression of p21 in KKU-M214 cells. Taken together, cisplatin and HDACIs combination may improve the therapeutic outcome in cholangiocarcinoma patients.

The Histone Deacetylase Inhibitors MS-275 and SAHA Suppress the p38 Mitogen-Activated Protein Kinase Signaling Pathway and Chemotaxis in Rheumatoid Arthritic Synovial Fibroblastic E11 Cells

Directory of Open Access Journals (Sweden)

Hai-Shu Lin

2013-11-01

Full Text Available MS-275 (entinostat and SAHA (vorinostat, two histone deacetylase (HDAC inhibitors currently in oncological trials, have displayed potent anti-rheumatic activities in rodent models of rheumatoid arthritis (RA. To further elucidate their anti-inflammatory mechanisms, the impact of MS-275 and SAHA on the p38 mitogen-activated protein kinase (MAPK signaling pathway and chemotaxis was assessed in human rheumatoid arthritic synovial fibroblastic E11 cells. MS-275 and SAHA significantly suppressed the expression of p38α  MAPK, but induced the expression of MAPK phosphatase-1 (MKP-1, an endogenous suppressor of p38α  in E11 cells. At the same time, the association between p38α and MKP-1 was up-regulated and consequently, the activation (phosphorylation of p38α  was inhibited. Moreover, MS-275 and SAHA suppressed granulocyte chemotactic protein-2 (GCP-2, monocyte chemotactic protein-2 (MCP-2 and macrophage migration inhibitory factor (MIF in E11 cells in a concentration-dependent manner. Subsequently, E11-driven migration of THP-1 and U937 monocytes was inhibited. In summary, suppression of the p38 MAPK signaling pathway and chemotaxis appear to be important anti-rheumatic mechanisms of action of these HDAC inhibitors.

Effects of treatment with suppressive combination antiretroviral drug therapy and the histone deacetylase inhibitor suberoylanilide hydroxamic acid; (SAHA on SIV-infected Chinese rhesus macaques.

Directory of Open Access Journals (Sweden)

Binhua Ling

Full Text Available Viral reservoirs-persistent residual virus despite combination antiretroviral therapy (cART-remain an obstacle to cure of HIV-1 infection. Difficulty studying reservoirs in patients underscores the need for animal models that mimics HIV infected humans on cART. We studied SIV-infected Chinese-origin rhesus macaques (Ch-RM treated with intensive combination antiretroviral therapy (cART and 3 weeks of treatment with the histone deacetyalse inhibitor, suberoylanilide hydroxamic acid (SAHA.SIVmac251 infected Ch-RM received reverse transcriptase inhibitors PMPA and FTC and integrase inhibitor L-870812 beginning 7 weeks post infection. Integrase inhibitor L-900564 and boosted protease inhibitor treatment with Darunavir and Ritonavir were added later. cART was continued for 45 weeks, with daily SAHA administered for the last 3 weeks, followed by euthanasia/necropsy. Plasma viral RNA and cell/tissue-associated SIV gag RNA and DNA were quantified by qRT-PCR/qPCR, with flow cytometry monitoring changes in immune cell populations.Upon cART initiation, plasma viremia declined, remaining <30 SIV RNA copy Eq/ml during cART, with occasional blips. Decreased viral replication was associated with decreased immune activation and partial restoration of intestinal CD4+ T cells. SAHA was well tolerated but did not result in demonstrable treatment-associated changes in plasma or cell associated viral parameters.The ability to achieve and sustain virological suppression makes cART-suppressed, SIV-infected Ch-RM a potentially useful model to evaluate interventions targeting residual virus. However, despite intensive cART over one year, persistent viral DNA and RNA remained in tissues of all three animals. While well tolerated, three weeks of SAHA treatment did not demonstrably impact viral RNA levels in plasma or tissues; perhaps reflecting dosing, sampling and assay limitations.

EFFECTS OF HISTONE DEACETYLASE INHIBITOR, SAHA, ON EFFECTOR AND FOXP3+ REGULATORY T CELLS IN RHESUS MACAQUES

OpenAIRE

Johnson, Jennifer; Pahuja, Anil; Graham, Melanie; Hering, Bernhard; Hancock, Wayne W.; Pratima, Bansal-Pakala

2008-01-01

SAHA, a histone deacetylase inhibitor (HDACi), is clinically approved for treatment of cutaneous T-cell lymphoma. Although the exact underlying mechanisms are unknown, HDACi arrest the cell cycle in rapidly proliferating tumor cells and promote their apoptosis. HDACi were also recently shown to enhance the production and suppressive functions of Foxp3+ regulatory T (Treg) cells in rodents, leading us to begin to investigate the actions of HDACi on rhesus monkey T cells for the sake of potenti...

Comparative accuracy of thermodynamic description of properties of a gas plasma in the Thomas--Fermi and Saha approximations

International Nuclear Information System (INIS)

Iosilevskii, I.L.; Gryaznov, V.K.

1982-01-01

The relation between two methods of thermodynamical calculation of matter in the gas-plasma region is analyzed. These methods are the traditional one, which uses the Saha ionization equilibrium equation, and extrapolation of the Thomas--Fermi approximation with quantum and exchange corrections. These approximations are compared with one another, and also with the results of exact theory at the total ionization limit and with experimental data for a cesium plasma in the partial-ionization region

Combined Treatment with Low Concentrations of Decitabine and SAHA Causes Cell Death in Leukemic Cell Lines but Not in Normal Peripheral Blood Lymphocytes

Directory of Open Access Journals (Sweden)

Barbora Brodská

2013-01-01

Full Text Available Epigenetic therapy reverting aberrant acetylation or methylation offers the possibility to target preferentially tumor cells and to preserve normal cells. Combination epigenetic therapy may further improve the effect of individual drugs. We investigated combined action of demethylating agent decitabine and histone deacetylase inhibitor SAHA (Vorinostat on different leukemic cell lines in comparison with peripheral blood lymphocytes. Large decrease of viability, as well as huge p21WAF1 induction, reactive oxygen species formation, and apoptotic features due to combined decitabine and SAHA action were detected in leukemic cell lines irrespective of their p53 status, while essentially no effect was observed in response to the combined drug action in normal peripheral blood lymphocytes of healthy donors. p53-dependent apoptotic pathway was demonstrated to participate in the wtp53 CML-T1 leukemic cell line response, while significant influence of reactive oxygen species on viability decrease has been detected in p53-null HL-60 cell line.

Validity of Saha's equation of thermal ionization for negatively charged spherical particles in complex plasmas in thermal equilibrium

International Nuclear Information System (INIS)

Sodha, M. S.; Mishra, S. K.

2011-01-01

The authors have discussed the validity of Saha's equation for the charging of negatively charged spherical particles in a complex plasma in thermal equilibrium, even when the tunneling of the electrons, through the potential energy barrier surrounding the particle is considered. It is seen that the validity requires the probability of tunneling of an electron through the potential energy barrier surrounding the particle to be independent of the direction (inside to outside and vice versa) or in other words the Born's approximation should be valid.

Emerging Trends in Applied Mathematics: Dedicated to the Memory of Sir Asutosh Mookerjee and Contributions of S.N. Bose, M.N. Saha and N.R. Sen

CERN Document Server

Basu, Uma; De, Soumen

2015-01-01

The book is based on research presentations at the international conference, “Emerging Trends in Applied Mathematics: In the Memory of Sir Asutosh Mookerjee, S.N. Bose, M.N. Saha, and N.R. Sen”, held at the Department of Applied Mathematics, University of Calcutta, during 12–14 February 2014. It focuses on various emerging and challenging topics in the field of applied mathematics and theoretical physics. The book will be a valuable resource for postgraduate students at higher levels and researchers in applied mathematics and theoretical physics. Researchers presented a wide variety of themes in applied mathematics and theoretical physics—such as emergent periodicity in a field of chaos; Ricci flow equation and Poincare conjecture; Bose–Einstein condensation; geometry of local scale invariance and turbulence; statistical mechanics of human resource allocation: mathematical modelling of job-matching in labour markets; contact problem in elasticity; the Saha equation; computational fluid dynamics with...

In silico modification of Zn2+ binding group of suberoylanilide hydroxamic acid (SAHA) by organoselenium compounds as Homo sapiens class II HDAC inhibitor of cervical cancer

Science.gov (United States)

Sumo Friend Tambunan, Usman; Bakri, Ridla; Aditya Parikesit, Arli; Ariyani, Titin; Dyah Puspitasari, Ratih; Kerami, Djati

2016-02-01

Cervical cancer is the most common cancer in women, and ranks seventh of all cancers worldwide, with 529000 cases in 2008 and more than 85% cases occur in developing countries. One way to treat this cancer is through the inhibition of HDAC enzymes which play a strategic role in the regulation of gene expression. Suberoyl Anilide Hydroxamic Acid (SAHA) or Vorinostat is a drug which commercially available to treat the cancer, but still has some side effects. This research present in silico SAHA modification in Zinc Binding Group (ZBG) by organoselenium compound to get ligands which less side effect. From molecular docking simulation, and interaction analysis, there are five best ligands, namely CC27, HA27, HB28, IB25, and KA7. These five ligands have better binding affinity than the standards, and also have interaction with Zn2+ cofactor of inhibited HDAC enzymes. This research is expected to produce more potent HDAC inhibitor as novel drug for cervical cancer treatment.

Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult subventricular cells

Directory of Open Access Journals (Sweden)

Doughty Martin L

2011-05-01

Full Text Available Abstract Background Histone deacetylases (HDACs are enzymes that modulate gene expression and cellular processes by deacetylating histones and non-histone proteins. While small molecule inhibitors of HDAC activity (HDACi are used clinically in the treatment of cancer, pre-clinical treatment models suggest they also exert neuroprotective effects and stimulate neurogenesis in neuropathological conditions. However, the direct effects of HDACi on cell cycle progression and proliferation, two properties required for continued neurogenesis, have not been fully characterized in adult neural stem cells (NSCs. In this study, we examined the effects of two broad class I and class II HDACi on adult mouse NSCs, the hydroxamate-based HDACi suberoylanilide hydroxamic acid (vorinostat, SAHA and the short chain fatty acid HDACi sodium butyrate. Results We show that both HDACi suppress the formation of neurospheres by adult mouse NSCs grown in proliferation culture conditions in vitro. DNA synthesis is significantly inhibited in adult mouse NSCs exposed to either SAHA or sodium butyrate and inhibition is associated with an arrest in the G1 phase of the cell cycle. HDACi exposure also resulted in transcriptional changes in adult mouse NSCs. Cdk inhibitor genes p21 and p27 transcript levels are increased and associated with elevated H3K9 acetylation levels at proximal promoter regions of p21 and p27. mRNA levels for notch effector Hes genes and Spry-box stem cell transcription factors are downregulated, whereas pro-neural transcription factors Neurog1 and Neurod1 are upregulated. Lastly, we show HDAC inhibition under proliferation culture conditions leads to long-term changes in cell fate in adult mouse NSCs induced to differentiate in vitro. Conclusion SAHA and sodium butyrate directly regulate cdk inhibitor transcription to control cell cycle progression in adult mouse NSCs. HDAC inhibition results in G1 arrest in adult mouse NSCs and transcriptional changes

Antisociální chování dospívajících: výsledky české části mezinárodního projektu SAHA

Czech Academy of Sciences Publication Activity Database

Sobotková, Veronika

2011-01-01

Roč. 8, č. 5 (2011), s. 6-7 ISSN 1214-8717 R&D Project s: GA AV ČR IBS7025354 Institutional research plan: CEZ:AV0Z70250504 Keywords : antisocial behavior * adolescence * SAHA project Subject RIV: AN - Psychology

Draft genome sequence of the extremely halophilic Halorubrum sp. SAH-A6 isolated from rock salts of the Danakil depression, Ethiopia

Directory of Open Access Journals (Sweden)

Ashagrie Gibtan

2016-12-01

Full Text Available The draft genome sequence of Halorubrum sp. SAH-A6, isolated from commercial rock salts of the Danakil depression, Ethiopia. The genome comprised 3,325,770 bp, with the G + C content of 68.0%. The strain has many genes which are responsible for secondary metabolites biosynthesis, transport and catabolism as compared to other Halorubrum archaea members. Abundant genes responsible for numerous transport systems, solute accumulation, and aromatic/sulfur decomposition were detected. The first genomic analysis encourages further research on comparative genomics, and biotechnological applications. The NCBI accession number for this genome is SAMN04278861 and ID: 4278861 and strain deposited with accession number KCTC 43215.

System safety analysis of an autonomous mobile robot

International Nuclear Information System (INIS)

Bartos, R.J.

1994-01-01

Analysis of the safety of operating and maintaining the Stored Waste Autonomous Mobile Inspector (SWAMI) II in a hazardous environment at the Fernald Environmental Management Project (FEMP) was completed. The SWAMI II is a version of a commercial robot, the HelpMate trademark robot produced by the Transitions Research Corporation, which is being updated to incorporate the systems required for inspecting mixed toxic chemical and radioactive waste drums at the FEMP. It also has modified obstacle detection and collision avoidance subsystems. The robot will autonomously travel down the aisles in storage warehouses to record images of containers and collect other data which are transmitted to an inspector at a remote computer terminal. A previous study showed the SWAMI II has economic feasibility. The SWAMI II will more accurately locate radioactive contamination than human inspectors. This thesis includes a System Safety Hazard Analysis and a quantitative Fault Tree Analysis (FTA). The objectives of the analyses are to prevent potentially serious events and to derive a comprehensive set of safety requirements from which the safety of the SWAMI II and other autonomous mobile robots can be evaluated. The Computer-Aided Fault Tree Analysis (CAFTA copyright) software is utilized for the FTA. The FTA shows that more than 99% of the safety risk occurs during maintenance, and that when the derived safety requirements are implemented the rate of serious events is reduced to below one event per million operating hours. Training and procedures in SWAMI II operation and maintenance provide an added safety margin. This study will promote the safe use of the SWAMI II and other autonomous mobile robots in the emerging technology of mobile robotic inspection

Democratic Values and Support for Militant Politics: Evidence from a National Survey of Pakistan

Science.gov (United States)

2012-11-27

Swami, Praveen . 2007. India, Pakistan and the Secret Jihad: The Covert War in Kashmir 1947–2004. London: Routledge. Terror Free Tomorrow and the...Collapse in the International System, Second Edition. New Haven: Yale University Press. 12   Swami, Praveen . 2007. India, Pakistan and the

A U.S. Base at Cam Ranh Bay, Vietnam: Will it Strengthen PACOM’s Efforts to Contain PRC Expansion in Southeast Asia?

Science.gov (United States)

2011-05-04

1967), 25-27. 10 Ibid. 11 Malcolm Moore, and Praveen Swami, “Vietnam Offers Navy Base to Foil China. Daily Telegraph (London), 8 November 2010...for U.S. Policy.” Congressional Research Service (Aug 6, 2010). Moore, Malcolm, and Praveen Swami. “Vietnam Offers Navy Base to Foil China

Robotic inspection of nuclear waste storage facilities

International Nuclear Information System (INIS)

Fulbright, R.; Stephens, L.M.

1995-01-01

The University of South Carolina and the Westinghouse Savannah River Company have developed a prototype mobile robot designed to perform autonomous inspection of nuclear waste storage facilities. The Stored Waste Autonomous Mobile Inspector (SWAMI) navigates and inspects rows of nuclear waste storage drums, in isles as narrow as 34 inches with drums stacked three high on each side. SWAMI reads drum barcodes, captures drum images, and monitors floor-level radiation levels. The topics covered in this article reporting on SWAMI include the following: overall system design; typical mission scenario; barcode reader subsystem; video subsystem; radiation monitoring subsystem; position determination subsystem; onboard control system hardware; software development environment; GENISAS, a C++ library; MOSAS, an automatic code generating tool. 10 figs

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences. Rahul Gaur. Articles written in Journal of Biosciences. Volume 32 Issue 4 June 2007 pp 747-754 Articles. Diet-dependent depletion of queuosine in tRNAs in Caenorhabditis elegans does not lead to a developmental block · Rahul Gaur Glenn R Björk Simon Tuck Umesh Varshney.

The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells

International Nuclear Information System (INIS)

Kerl, Kornelius; Eveslage, Maria; Jung, Manfred; Meisterernst, Michael; Frühwald, Michael; Ries, David; Unland, Rebecca; Borchert, Christiane; Moreno, Natalia; Hasselblatt, Martin; Jürgens, Heribert; Kool, Marcel; Görlich, Dennis

2013-01-01

Rhabdoid tumors are highly aggressive malignancies affecting infants and very young children. In many instances these tumors are resistant to conventional type chemotherapy necessitating alternative approaches. Proliferation assays (MTT), apoptosis (propidium iodide/annexin V) and cell cycle analysis (DAPI), RNA expression microarrays and western blots were used to identify synergism of the HDAC (histone deacetylase) inhibitor SAHA with fenretinide, tamoxifen and doxorubicin in rhabdoidtumor cell lines. HDAC1 and HDAC2 are overexpressed in primary rhabdoid tumors and rhabdoid tumor cell lines. Targeting HDACs in rhabdoid tumors induces cell cycle arrest and apoptosis. On the other hand HDAC inhibition induces deregulated gene programs (MYCC-, RB program and the stem cell program) in rhabdoid tumors. These programs are in general associated with cell cycle progression. Targeting these activated pro-proliferative genes by combined approaches of HDAC-inhibitors plus fenretinide, which inhibits cyclinD1, exhibit strong synergistic effects on induction of apoptosis. Furthermore, HDAC inhibition sensitizes rhabdoid tumor cell lines to cell death induced by chemotherapy. Our data demonstrate that HDAC inhibitor treatment in combination with fenretinide or conventional chemotherapy is a promising tool for the treatment of chemoresistant rhabdoid tumors

Koit rikkus hea ajakirjandustava / Eve Rohtla

Index Scriptorium Estoniae

Rohtla, Eve, 1961-

2007-01-01

Ilmunud ka: Kesknädal, 11. apr. 2007, lk. 5. Pressinõukogu arutas Heimar Lengi kaebust ajalehes Koit 8.02. 2007 avaldatud valimisreklaami peale ning otsustas, et ajaleht rikkus head ajakirjandustava. Heimar Lenk polnud rahul, et tema tekst ei sisaldanud märget "Tasutud tekst", kuigi ta oli selle avaldamise eest ajalehele maksnud. Samuti polnud ta rahul, et tema reklaamteksti kohal oli teda halvustav lugejakiri

Examination of the Validity of the Saha Equation in a Gas Discharge

Energy Technology Data Exchange (ETDEWEB)

Shaw, J. F.; Kruger, C. H.; Mitchner, M.; Viegas, J. R. [Stanford University, CA (United States)

1966-11-15

-Maxwellian distribution function with depleted tail, are considered. Under some conditions, either mechanism may produce a degree of ionization considerably different from that predicted by the Saha equation at the electron temperature. (author)

Lessons from India’s Counterinsurgency Campaign in Jammu and Kashmir

Science.gov (United States)

2013-12-10

counterproductive in reducing the overall violence in Kashmir. Figures compiled from data kept by the Indian Ministry of Home Affairs by Indian journalist Praveen ...force would only gain more support for the 48Schofield, Kashmir in Conflict, 148-150. 49The 1990 fatality figures compiled by Praveen Swami (India...India, Pakistan, and the Unending War. New York: I.B.Tauris & Co Ltd, 2003. Swami, Praveen . “Failed Threats and Flawed Fences: India’s Military

XV and XVI SERC Main Schools in Theoretical High Energy Physics held at the Saha Institute of Nuclear Physics and Harish-Chandra Research Institute

CERN Document Server

2005-01-01

Current research in High Energy Physics focuses on a number of enigmatic issues that go beyond the very successful Standard Model of particle physics. Among these are the problem of neutrino mass, the (as yet) unobserved Higgs particle, the quark-gluon plasma, quantum aspects of gravity, and the so--called hierarchy problem. Satisfactory resolution of these important questions will take much research effort in both theory and experiment. The Science & Engineering Research Council, Department of Science & Technology has sponsored a series of SERC Schools in Theoretical High Energy Physics over the past several years, to provide instruction and training to graduate students working for research degrees. This book is an outcome of the schools held at the Saha Institute of Nuclear Physics, Kolkata in 2000, and at the Harish-Chandra Research Institute, Allahabad in 2001. Based on lectures by active researchers in the field---Rajiv Gavai, Debashis Ghoshal, Dileep Jatkar, Anjan Joshipura, Biswarup Mukhopadhy...

Explaining Success and Failure: Counterinsurgency in Malaya and India

Science.gov (United States)

2010-12-01

Journal of Peasant Studies 33, no. 1 (January 2006): 89. 24 Praveen Swami, “For a Review of Counterinsurgency Doctrine,”The Hindu, April 13, 2010...Malaya in the 1950s are used as a guide in formulating counterinsurgency doctrine against the Maoist-type of insurgency in India as per Praveen ...relief camps. The 39 Praveen Swami, “For a Review of Counterinsurgency Doctrine,” The Hindu, April 13, 2010, http://www.thehindu.com/opinion/lead

Enhanced suppression of tumor growth by concomitant treatment of human lung cancer cells with suberoylanilide hydroxamic acid and arsenic trioxide

International Nuclear Information System (INIS)

Chien, Chia-Wen; Yao, Ju-Hsien; Chang, Shih-Yu; Lee, Pei-Chih; Lee, Te-Chang

2011-01-01

The efficacy of arsenic trioxide (ATO) against acute promyelocytic leukemia (APL) and relapsed APL has been well documented. ATO may cause DNA damage by generating reactive oxygen intermediates. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, modulates gene and protein expression via histone-dependent or -independent pathways that may result in chromatin decondensation, cell cycle arrest, differentiation, and apoptosis. We investigated whether ATO and SAHA act synergistically to enhance the death of cancer cells. Our current findings showed that combined treatment with ATO and SAHA resulted in enhanced suppression of non-small-cell lung carcinoma in vitro in H1299 cells and in vivo in a xenograft mouse model. Flow cytometric analysis of annexin V+ cells showed that apoptotic cell death was significantly enhanced after combined treatment with ATO and SAHA. At the doses used, ATO did not interfere with cell cycle progression, but SAHA induced p21 expression and led to G1 arrest. A Comet assay demonstrated that ATO, but not SAHA, induced DNA strand breaks in H1299 cells; however, co-treatment with SAHA significantly increased ATO-induced DNA damage. Moreover, SAHA enhanced acetylation of histone H3 and sensitized genomic DNA to DNase I digestion. Our results suggest that SAHA may cause chromatin relaxation and increase cellular susceptibility to ATO-induced DNA damage. Combined administration of SAHA and ATO may be an effective approach to the treatment of lung cancer. -- Highlights: ► ATO and SAHA are therapeutic agents with different action modes. ► Combination of ATO and SAHA synergistically inhibits tumor cell growth. ► SAHA loosens chromatin structure resulting in increased sensitivity to DNase I. ► ATO-induced DNA damage and apoptosis are enhanced by co-treatment with SAHA.

Histone Deacetylase Inhibitor Induced Radiation Sensitization Effects on Human Cancer Cells after Photon and Hadron Radiation Exposure

Directory of Open Access Journals (Sweden)

Ariungerel Gerelchuluun

2018-02-01

Full Text Available Suberoylanilide hydroxamic acid (SAHA is a histone deacetylase inhibitor, which has been widely utilized throughout the cancer research field. SAHA-induced radiosensitization in normal human fibroblasts AG1522 and lung carcinoma cells A549 were evaluated with a combination of γ-rays, proton, and carbon ion exposure. Growth delay was observed in both cell lines during SAHA treatment; 2 μM SAHA treatment decreased clonogenicity and induced cell cycle block in G1 phase but 0.2 μM SAHA treatment did not show either of them. Low LET (Linear Energy Transfer irradiated A549 cells showed radiosensitization effects on cell killing in cycling and G1 phase with 0.2 or 2 μM SAHA pretreatment. In contrast, minimal sensitization was observed in normal human cells after low and high LET radiation exposure. The potentially lethal damage repair was not affected by SAHA treatment. SAHA treatment reduced the rate of γ-H2AX foci disappearance and suppressed RAD51 and RPA (Replication Protein A focus formation. Suppression of DNA double strand break repair by SAHA did not result in the differences of SAHA-induced radiosensitization between human cancer cells and normal cells. In conclusion, our results suggest SAHA treatment will sensitize cancer cells to low and high LET radiation with minimum effects to normal cells.

2008. aasta eelarve on tulevikkuvaatav / Ivari Padar

Index Scriptorium Estoniae

Padar, Ivari, 1965-

2008-01-01

2008. aasta riigieelarvest. Muudatused maksumaksjale, turvalisus, haridus ja sotsiaalne kindlus, hädavajalik palgatõus. Lisatud tabelid: 2008. a. valitsemisala eelarvete kasvude pingerida; Suurimad kulud eelarves. Vt. samas: Kajar Lember. 2008. eelarve ei ole konservatiivne; Kristen Michal. Eelarve arvestab erinevate huvidega; Juhan Parts. Eelarve üle mõistab kohut käimasolev aasta; Aivar Sõerd. 2008. aasta riigieelarve kasvatab inflatsiooni; Margus Tsahkna. Eelarvega võib rahule jääda!; Rein Järvelill. Oleme 2008. aasta eelarvega rahul!; Toomas Trapido. Eelarve ei arvesta kiireneva inflatsiooni ega maailmaturu energiahindadega

Vorinostat enhances chemosensitivity to arsenic trioxide in K562 cell line

Directory of Open Access Journals (Sweden)

Nainong Li

2015-05-01

Full Text Available Objective. This study aimed to investigate the chemosensitive augmentation effect and mechanism of HDAC inhibitor Vorinostat (SAHA in combination with arsenic trioxide (ATO on proliferation and apoptosis of K562 cells.Methods. The CCK-8 assay was used to compare proliferation of the cells. Annexin-V and PI staining by flow cytometry and acridine orange/ethidium bromide stains were used to detect and quantify apoptosis. Western blot was used to detect expression of p21, Akt, pAkt, p210, Acetyl-Histone H3, and Acetyl-Histone H4 proteins.Results. SAHA and ATO inhibited proliferation of K562 cells in an additive and time- and dose-dependent manner. SAHA in combination with ATO showed significant apoptosis of K562 cells in comparison to the single drugs alone (p < 0.01. Both SAHA and ATO alone and in combination showed lower levels of p210 expression. SAHA and SAHA and ATO combined treatment showed increased levels of Acetyl-Histone H3 and Acetyl-Histone H4 protein expression. SAHA alone showed increased expression of p21, while ATO alone and in combination with SAHA showed no significant change. SAHA and ATO combined therapy showed lower levels of Akt and pAkt protein expression than SAHA or ATO alone.Conclusion. SAHA and ATO combined treatment inhibited proliferation, induced apoptosis, and showed a chemosensitive augmentation effect on K562 cells. The mechanism might be associated with increasing histone acetylation levels as well as regulating the Akt signaling pathway.

Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-α through up-regulation of TNF receptor 1 in lung cancer cells.

Science.gov (United States)

You, Bo Ra; Han, Bo Ram; Park, Woo Hyun

2017-03-14

Suberoylanilide hydroxamic acid (SAHA) as a histone deacetylase (HDAC) inhibitor has anti-cancer effect. Here, we evaluated the effect of SAHA on HDAC activity and cell growth in many normal lung and cancer cells. We observed that the HDAC activities of lung cancer cells were higher than that of normal lung cells. SAHA inhibited the growth of lung cancer cells regardless of the inhibitory effect on HDAC. This agent induced a G2/M phase arrest and apoptosis, which was accompanied by mitochondrial membrane potential (MMP: ΔΨm) loss in lung cancer cells. However, SAHA did not induce cell death in normal lung cells. All tested caspase inhibitors prevented apoptotic cell death in SAHA-treated A549 and Calu-6 lung cancer cells. Treatment with tumor necrosis factor-alpha (TNF-α) enhanced apoptosis in SAHA-treated lung cancer cells through caspase-8 and caspase-9 activations. Especially, SAHA increased the expression level of TNF-α receptor 1 (TNFR1), especially acetylation of the region of TNFR1 promoter -223/-29 in lung cancer cells. The down-regulation of TNFR1 suppressed apoptosis in TNF-α and SAHA-treated lung cancer cells. In conclusion, SAHA inhibited the growth of lung cancer cells via a G2/M phase arrest and caspase-dependent apoptosis. SAHA also enhanced apoptotic effect of TNF-α in human lung cancer cells through up-regulation of TNFR1. TNF-α may be a key to improve anti-cancer effect of HDAC inhibitors.

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: possible relevance for treatment-resistant depression

KAUST Repository

Meylan, Elsa M.; Halfon, Olivier; Magistretti, Pierre J.; Cardinaux, Jean-René

2016-01-01

Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these medications. A better understanding of the neurobiology of depression and the mechanisms underlying antidepressant response is thus critically needed. We previously reported that mice lacking CREB-regulated transcription coactivator 1 (CRTC1) exhibit a depressive-like phenotype and a blunted antidepressant response to the selective serotonin reuptake inhibitor fluoxetine. In this study, we similarly show that Crtc1‒/‒ mice are resistant to the antidepressant effect of chronic desipramine in a behavioral despair paradigm. Supporting the blunted response to this tricyclic antidepressant, we found that desipramine does not significantly increase the expression of Bdnf and Nr4a1-3 in the hippocampus and prefrontal cortex of Crtc1‒/‒ mice. Epigenetic regulation of neuroplasticity gene expression has been associated with depression and antidepressant response, and histone deacetylase (HDAC) inhibitors have been shown to have antidepressant-like properties. Here, we show that unlike conventional antidepressants, chronic systemic administration of the HDAC inhibitor SAHA partially rescues the depressive-like behavior of Crtc1‒/‒ mice. This behavioral effect is accompanied by an increased expression of Bdnf, but not Nr4a1-3, in the prefrontal cortex of these mice, suggesting that this epigenetic intervention restores the expression of a subset of genes by acting downstream of CRTC1. These findings suggest that CRTC1 alterations may be associated with treatment-resistant depression, and support the interesting possibility that targeting HDACs may be a useful therapeutic strategy in antidepressant development.

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: possible relevance for treatment-resistant depression

KAUST Repository

Meylan, Elsa M.

2016-03-09

Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these medications. A better understanding of the neurobiology of depression and the mechanisms underlying antidepressant response is thus critically needed. We previously reported that mice lacking CREB-regulated transcription coactivator 1 (CRTC1) exhibit a depressive-like phenotype and a blunted antidepressant response to the selective serotonin reuptake inhibitor fluoxetine. In this study, we similarly show that Crtc1‒/‒ mice are resistant to the antidepressant effect of chronic desipramine in a behavioral despair paradigm. Supporting the blunted response to this tricyclic antidepressant, we found that desipramine does not significantly increase the expression of Bdnf and Nr4a1-3 in the hippocampus and prefrontal cortex of Crtc1‒/‒ mice. Epigenetic regulation of neuroplasticity gene expression has been associated with depression and antidepressant response, and histone deacetylase (HDAC) inhibitors have been shown to have antidepressant-like properties. Here, we show that unlike conventional antidepressants, chronic systemic administration of the HDAC inhibitor SAHA partially rescues the depressive-like behavior of Crtc1‒/‒ mice. This behavioral effect is accompanied by an increased expression of Bdnf, but not Nr4a1-3, in the prefrontal cortex of these mice, suggesting that this epigenetic intervention restores the expression of a subset of genes by acting downstream of CRTC1. These findings suggest that CRTC1 alterations may be associated with treatment-resistant depression, and support the interesting possibility that targeting HDACs may be a useful therapeutic strategy in antidepressant development.

In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model

International Nuclear Information System (INIS)

Thiemann, Markus; Kulozik, Andreas E; Debus, Jürgen; Huber, Peter E; Battmann, Claudia; Oertel, Susanne; Ehemann, Volker; Weichert, Wilko; Stenzinger, Albrecht; Bischof, Marc; Weber, Klaus-J; Perez, Ramon Lopez; Haberkorn, Uwe

2012-01-01

Histone deacetylase inhibitors are promising new substances in cancer therapy and have also been shown to sensitize different tumor cells to irradiation (XRT). We explored the effect as well as the radiosensitizing properties of suberoylanilide hydroxamic acid (SAHA) in vivo in a malignant rhabdoid tumor (MRT) mouse model. Potential radiosensitization by SAHA was assessed in MRT xenografts by analysis of tumor growth delay, necrosis (HE), apoptosis (TUNEL), proliferation (ki-67) and γH2AX expression as well as dynamic 18 F-Fluorodeoxyglucose Positron Emission Tomography ( 18 F-FDG -PET) after treatment with either SAHA alone, single-dose (10 Gy) or fractionated XRT (3 × 3Gy) solely as well as in combination with SAHA compared to controls. SAHA only had no significant effect on tumor growth. Combination of SAHA for 8 days with single-dose XRT resulted in a higher number of complete remissions, but failed to prove a significant growth delay compared to XRT only. In contrast fractionated XRT plus SAHA for 3 weeks did induce significant tumor growth delay in MRT-xenografts. The histological examination showed a significant effect of XRT in tumor necrosis, expression of Ki-67, γH2AX and apoptosis. SAHA only had no significant effect in the histological examination. Comparison of xenografts treated with XRT and XRT plus SAHA revealed a significantly increased γH2AX expression and apoptosis induction in the mice tumors after combination treatment with single-dose as well as fractionated XRT. The combination of SAHA with XRT showed a tendency to increased necrosis and decrease of proliferation compared to XRT only, which, however, was not significant. The 18 F-FDG-PET results showed no significant differences in the standard uptake value or glucose transport kinetics after either treatment. SAHA did not have a significant effect alone, but proved to enhance the effect of XRT in our MRT in vivo model

Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors

Directory of Open Access Journals (Sweden)

Yun-feng Qi

2014-01-01

Full Text Available SAHA (suberoylanilide hydroxamic acid or vorinostat is the first nonselective histone deacetylase (HDAC inhibitor approved by the US Food and Drug Administration (FDA. SAHA affects histone acetylation in chromatin and a variety of nonhistone substrates, thus influencing many cellular processes. In particularly, SAHA induces selective apoptosis of tumor cells, although the mechanism is not well understood. A series of microarray experiments was recently conducted to investigate tumor cell-selective proapoptotic transcriptional responses induced by SAHA. Based on that gene expression time series, we propose a novel framework for detailed analysis of the mechanism of tumor cell apoptosis selectively induced by SAHA. Our analyses indicated that SAHA selectively disrupted the DNA damage response, cell cycle, p53 expression, and mitochondrial integrity of tumor samples to induce selective tumor cell apoptosis. Our results suggest a possible regulation network. Our research extends the existing research.

A facile route to form self-carried redox-responsive vorinostat nanodrug for effective solid tumor therapy

Directory of Open Access Journals (Sweden)

Han LQ

2016-11-01

Full Text Available Leiqiang Han, Tianqi Wang, Jingliang Wu, Xiaolan Yin, Hao Fang, Na Zhang School of Pharmaceutical Science, Shandong University, Ji’nan, Shandong, People’s Republic of China Abstract: Small molecule-based nanodrugs with nanoparticles (NPs that are mainly composed of small molecules, have been considered as a promising candidate for a next-generation nanodrug, owing to their unique properties. Vorinostat (SAHA is a canonical US Food and Drug Administration-approved histone deacetylase (HDAC inhibitor for the treatment of cutaneous T-cell lymphoma. However, the lack of efficacy against solid tumors hinders its progress in clinical use. Herein, a novel nanodrug of SAHA was developed based on disulfide-linked prodrug SAHA-S-S-VE. SAHA-S-S-VE could self-assemble into 148 nm NPs by disulfide-induced mechanisms, which were validated by molecular dynamics simulations. Under reduced conditions, the redox-responsive behavior of SAHA-S-S-VE was investigated, and the HDAC inhibition results verified the efficient release of free SAHA. With a biocompatible d-a-tocopheryl polyethylene glycol succinate (TPGS functionalization, the SAHA-S-S-VE/TPGS NPs exhibited low critical aggregation concentration of 4.5 µM and outstanding stability in vitro with drug-loading capacity of 24%. In vitro biological assessment indicated that SAHA-S-S-VE/TPGS NPs had significant anticancer activity against HepG2. Further in vivo evaluation demonstrated that the resulting NPs could be accumulated in the tumor region and inhibit the tumor growth effectively. This approach, which turned SAHA into a self-assembled redox-responsive nanodrug, provided a new channel for the use of HDAC inhibitor in solid tumor therapy. Keywords: SAHA, HDAC, small molecule, nanoparticles, self-assemble, disulfide bond

Uvletshenije krupnõhh mezhdunarodnõhh firm innovatsijami stalo prohodit

Index Scriptorium Estoniae

2008-01-01

Konsultatsioonifirma Boston Consulting Group uuris, kuivõrd on ettevõtted rahul oma innovatsiooniinvesteeringu tootlusega. Tabel: Mis on suurimad takistused innovatsiooniinvesteeringute tasuvaks muutmisel?

List of Participants 1051

Indian Academy of Sciences (India)

Carroll Alan, Brookhaven National Laboratory, Upton, NY 11973-5000, USA acarroll@bnl.gov. Chakrabarti Dipankar, Saha Institute of Nuclear Physics, 1/AF, Bidhan Nagar, Kolkata 700 064,. India dipankar@theory.saha.ernet.in. Chakraborty Purnendu, Saha Institute of Nuclear Physics, 1/AF, Bidhan Nagar, Kolkata 700 ...

Bhaktivedanta Swami’s rhetoric of violence

Directory of Open Access Journals (Sweden)

Måns Broo

2006-01-01

Full Text Available This article puts a part of Bhaktivedanta Swami’s rhetoric of violence into a larger context that has previously been neglected: that of early- to mid-twentieth century Bengali politics. The author also pinpoints some other factors behind them, such as his literal reading of the Gaudiya Vaishnava scriptures and his flair for drama. In this, the author has not tried to exonerate Bhaktivedanta Swami for his more radically politically incorrect opinions. There is no reason why in the 1970s even an Indian could believe, for example, that Hitler killed Jews because they financed his enemies. Rather, the author tries to begin broadening the picture of Bhaktivedanta Swami by looking at him as a product both of his spiritual predecessors and of his more worldly background. Seeing Bhaktivedanta Swami not only as the great ‘transcendental’ founder-acharya of ISKCON, but also as an elderly gentle­ man, at times erring on relative, human issues, is a viewpoint shared by many ISKCON intellectuals today. For some apologists within the movement, however, taking this path is seen as exceedingly risky, and they fight it vehemently, claiming that the entire future of the movement hinges on being faithful to all the words of its founder.

78 FR 65272 - Circular Welded Carbon Steel Pipes and Tubes From Thailand: Final Results of Antidumping Duty...

Science.gov (United States)

2013-10-31

..., Saha Thai Steel Pipe (Public) Company, Ltd. (Saha Thai), and Pacific Pipe Company Limited (Pacific Pipe... Pipe (Public) Company, Ltd 0.00 Pacific Pipe Company Limited * * No shipments or sales subject to this... parties to comment on the Preliminary Results. Saha Thai, Wheatland Tube Company, and United States Steel...

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses vasculogenic mimicry and proliferation of highly aggressive pancreatic cancer PaTu8988 cells

International Nuclear Information System (INIS)

Xu, Xing-dong; Yang, Lan; Zheng, Li-yun; Pan, Yan-yan; Cao, Zhi-fei; Zhang, Zhi-qing; Zhou, Quan-sheng; Yang, Bo; Cao, Cong

2014-01-01

Pancreatic cancer is one of the most aggressive human malignancies with a extremely low 5-year survival rate. Hence, the search for more effective anti-pancreatic cancer agents is urgent. PaTu8988 pancreatic cancer cells were treated with different concentrations of suberoylanilide hydroxamic acid (SAHA), cell survival, proliferation, migration and vasculogenic mimicry (VM) were analyzed. Associated signaling changes were also analyzed by RT-PCR and Western blots. Here, we reported that SAHA, a histone deacetylase inhibitor (HDACi), exerted significant inhibitory efficiency against pancreatic cancer cell survival, proliferation, migration and VM. SAHA dose-dependently inhibited PaTu8988 pancreatic cancer cell growth with the IC-50 of 3.4 ± 0. 7 μM. Meanwhile, SAHA suppressed PaTu8988 cell cycle progression through inducing G2/M arrest, which was associated with cyclin-dependent kinase 1 (CDK-1)/cyclin-B1 degradation and p21/p27 upregulation. Further, SAHA induced both apoptotic and non-apoptotic death of PaTu8988 cells. Significantly, SAHA suppressed PaTu8988 cell in vitro migration and cell-dominant tube formation or VM, which was accompanied by semaphorin-4D (Sema-4D) and integrin-β5 down-regulation. Our evidences showed that Akt activation might be important for Sema-4D expression in PaTu8988 cells, and SAHA-induced Sema-4D down-regulation might be associated with Akt inhibition. This study is among the first to report the VM formation in cultured human pancreatic cancer cells. And we provided strong evidence to suggest that SAHA executes significant anti-VM efficiency in the progressive pancreatic cancer cells. Thus, SAHA could be further investigated as a promising anti-pancreatic cancer agent

Metabolic changes in rat serum after administration of suberoylanilide hydroxamic acid and discriminated by SVM.

Science.gov (United States)

Yu, J; Wu, H; Lin, Z; Su, K; Zhang, J; Sun, F; Wang, X; Wen, C; Cao, H; Hu, L

2017-12-01

Suberoylanilide hydroxamic acid (SAHA) exerts marked anticancer effects via promotion of apoptosis, cell cycle arrest, and prevention of oncogene expression. In this study, serum metabolomics and artificial intelligence recognition were used to investigate SAHA toxicity. Forty rats (220 ± 20 g) were randomly divided into control and three SAHA groups (low, medium, and high); the experimental groups were treated with 12.3, 24.5, or 49.0 mg kg -1 SAHA once a day via intragastric administration. After 7 days, blood samples from the four groups were collected and analyzed by gas chromatography-mass spectrometry, and pathological changes in the liver were examined using microscopy. The results showed that increased levels of urea, oleic acid, and glutaconic acid were the most significant indicators of toxicity. Octadecanoic acid, pentadecanoic acid, glycerol, propanoic acid, and uric acid levels were lower in the high SAHA group. Microscopic observation revealed no obvious damage to the liver. Based on these data, a support vector machine (SVM) discrimination model was established that recognized the metabolic changes in the three SAHA groups and the control group with 100% accuracy. In conclusion, the main toxicity caused by SAHA was due to excessive metabolism of saturated fatty acids, which could be recognized by an SVM model.

Kirkilas appeals to patriotism of private energy firm

Index Scriptorium Estoniae

2007-01-01

Leedu peaminister kutsub kolme Leedu energeetikaettevõtet ühinema ehitamaks uut tuumaelektrijaama. Valitsus pole rahul ühinevate ettevõtete varade hinnanguga, mille tegi audiitorfirma KPMG Baltics

Cryptococcus

Indian Academy of Sciences (India)

Vikas Yadav

The Molecular Mycology Laboratory. CSIR, DBT, SERB,. CEFIPRA (Indo-French), IJSPS (Indo-Japan). JNCASR (intramural). TATA innovation Fellowship. Rahul Siddharthan. DD Dubey. German Larriba. Joseph Heitman.

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru N. Jayaraman, Indian Institute of Science, Bengaluru K C Kumara Swamy, University of Hyderabad, Hyderabad J N Moorthy, Indian Institute of Technology, Kanpur

Transparency issues still plague business in Latvia

Index Scriptorium Estoniae

2010-01-01

Läti Kaubanduskoja teatel ei ole investorid rahul korruptsiooni ja läbipaistvusega Läti ärikeskkonnas. Läti valitsuselt oodatakse tõhusamaid samme majandus- ja investeerimistingimuste parandamiseks

Invsteeringutoetuste saajate ring väheneb / Ain Lember

Index Scriptorium Estoniae

Lember, Ain

2009-01-01

Eestimaa talupidajate keskliit ei ole rahul mikropõllumajandusettevõtte arendamise investeeringutoetuse (meede 1.4.1) ja loomakasvatusehitiste investeeringutoetuse (meede 1.4.2) määruses tehtud muudatustega

Inimeste taskust võetakse vägisi 450 miljonit krooni / Krista Taim

Index Scriptorium Estoniae

Taim, Krista

2002-01-01

Eesti Ametiühingute Keskliidu õigussekretäri Margarita Tuchi sõnul pole ametiühingud rahul ravikindlustusseadusega, mis riigikogus teisele lugemisele jõudis. Kommenteerib Eiki Nestor. Parlamendisaadik

The year of evolution for 2002 / Tim Ferland

Index Scriptorium Estoniae

Ferland, Tim

2003-01-01

Eesti-Ameerika Kaubandus-Tööstuskoja liikmed on esimese tegutsemisaastaga rahul. Aktiivselt osaleti NATO Baltimaadesse laienemise diskussioonides. Lisa: Eesti sai kutse ühineda NATO-ga 21. novembril 2002

Modulation of radiation response by histone deacetylase inhibition

International Nuclear Information System (INIS)

Chinnaiyan, Prakash; Vallabhaneni, Geetha; Armstrong, Eric M.S.; Huang, Shyh-Min; Harari, Paul M.

2005-01-01

Purpose: Histone deacetylase (HDAC) inhibitors, which modulate chromatin structure and gene expression, represent a class of anticancer agents that hold particular potential as radiation sensitizers. In this study, we examine the capacity of the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) to modulate radiation response in human tumor cell lines and explore potential mechanisms underlying these interactions. Methods and materials: Cell proliferation: Exponentially growing tumor cells were incubated in medium containing 0-10 μM of SAHA for 72 h. Cells were fixed/stained with crystal violet to estimate cell viability. Apoptosis: Caspase activity was analyzed by fluorescence spectroscopy using a fluorescein labeled pan-caspase inhibitor. Cells were harvested after 48 h of exposure to SAHA (1.0 μM), radiation (6 Gy), or the combination. Whole cell lysates were evaluated for poly(ADP-ribose) polymerase (PARP) cleavage by western blot analysis. Radiation survival: Cells were exposed to varying doses of radiation ± 3 days pretreatment with SAHA (0.75-1.0 μM). After incubation intervals of 14-21 days, colonies were stained with crystal violet and manually counted. Immunocytochemistry: Cells were grown and treated in chamber slides. At specified times after treatment with SAHA, cells were fixed in paraformaldehyde, permeabilized in methanol, and probed with primary and secondary antibody solutions. Slides were analyzed using an epifluorescent microscope. Results: SAHA induced a dose-dependent inhibition of proliferation in human prostate (DU145) and glioma (U373vIII) cancer cell lines. Exposure to SAHA enhanced radiation-induced apoptosis as measured by caspase activity (p < 0.05) and PARP cleavage. The impact of SAHA on radiation response was further characterized using clonogenic survival analysis, which demonstrated that treatment with SAHA reduced tumor survival after radiation exposure. We identified several oncoproteins and DNA damage repair proteins

Density functional study of : Electronic and optical properties

Indian Academy of Sciences (India)

K C Bhamu

3Department of Physics, Swami Keshvanand Insitute of Technology, Management and Gramothan, ... Published online 20 June 2017. Abstract. This paper focusses on the electronic and optical properties of scandium-based silver delafossite.

Muuga terminal 2 - panus Vene Raudteele. Konkurent tooks terminali teenuste odavnemise / Jaroslav Tavgen

Index Scriptorium Estoniae

Tavgen, Jaroslav

2011-01-01

Muuga konteinerterminali operaatori konkursi kaotanud Muuga CT omanik AS Transiidikeskus ei ole Tallinna Sadama otsusega rahul ja leiab, et selle konkursi võitnud Rail Garant ei suuda kaubavedu suurendada

Muusikamaailm / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

1999-01-01

La Scalaga ei olda enam rahul, Dresdenis tuli lavale Richard Straussi ooper "Ariadne Naxoselt", uus orkestriteos John Adamsilt, Müncheni muusikabiennaali uudiseid, suri üks rahvusvahelise kooriliikumise silmapaistvamaid tegelasi

Publisher's Note: ''The MaPLE device of Saha Institute of Nuclear Physics: Construction and its plasma aspects'' [Rev. Sci. Instrum. 81, 073507 (2010)

International Nuclear Information System (INIS)

Pal, Rabindranath; Biswas, Subir; Basu, Subhasis; Chattopadhyay, Monobir; Basu, Debjyoti; Chaudhuri, Manis

2010-01-01

The Magnetized Plasma Linear Experimental (MaPLE) device is a low cost laboratory plasma device at Saha Institute of Nuclear Physics fabricated in-house with the primary aim of studying basic plasma physics phenomena such as plasma instabilities, wave propagation, and their nonlinear behavior in magnetized plasma regime in a controlled manner. The machine is specially designed to be a versatile laboratory device that can provide a number of magnetic and electric scenario to facilitate such studies. A total of 36 number of 20-turn magnet coils, designed such as to allow easy handling, is capable of producing a uniform, dc magnetic field of about 0.35 T inside the plasma chamber of diameter 0.30 m. Support structure of the coils is planned in an innovative way facilitating straightforward fabrication and easy positioning of the coils. Further special feature lies in the arrangement of the spacers between the coils that can be maneuvered rather easily to create different magnetic configurations. Various methods of plasma production can be suitably utilized according to the experimental needs at either end of the vacuum vessel. In the present paper, characteristics of a steady state plasma generated by electron cyclotron resonance method using 2.45 GHz microwave power are presented. Scans using simple probe drives revealed that a uniform and long plasma column having electron density ∼ 3–5×1010 cm−3 and temperature ∼ 7–10 eV, is formed in the center of the plasma chamber which is suitable for wave launching experiments.

Suberoylanilide hydroxamic acid affects γH2AX expression in osteosarcoma, atypical teratoid rhabdoid tumor and normal tissue cell lines after irradiation

International Nuclear Information System (INIS)

Blattmann, C.; Oertel, S.; Thiemann, M.; Weber, K.J.; Schmezer, P.; Zelezny, O.; Lopez Perez, R.; Kulozik, A.E.; Debus, J.; Ehemann, V.

2012-01-01

Osteosarcoma and atypical teratoid rhabdoid tumors are tumor entities with varying response to common standard therapy protocols. Histone acetylation affects chromatin structure and gene expression which are considered to influence radiation sensitivity. The aim of this study was to investigate the effect of the combination therapy with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) and irradiation on atypical teratoid rhabdoid tumors and osteosarcoma compared to normal tissue cell lines. Clonogenic assay was used to determine cell survival. DNA double-strand breaks (DSB) were examined by pulsed-field electrophoresis (PFGE) as well as by γH2AX immunostaining involving flow cytometry, fluorescence microscopy, and immunoblot analysis. SAHA lead to an increased radiosensitivity in tumor but not in normal tissue cell lines. γH2AX expression as an indicator for DSB was significantly increased when SAHA was applied 24 h before irradiation to the sarcoma cell cultures. In contrast, γH2AX expression in the normal tissue cell lines was significantly reduced when irradiation was combined with SAHA. Analysis of initial DNA fragmentation and fragment rejoining by PFGE, however, did not reveal differences in response to the SAHA pretreatment for either cell type. SAHA increases radiosensitivity in tumor but not normal tissue cell lines. The increased H2AX phosphorylation status of the SAHA-treated tumor cells post irradiation likely reflects its delayed dephosphorylation within the DNA damage signal decay rather than chromatin acetylation-dependent differences in the overall efficacy of DSB induction and rejoining. The results support the hypothesis that combining SAHA with irradiation may provide a promising strategy in the treatment of solid tumors. (orig.)

Suberoylanilide Hydroxyamic Acid Modification of Chromatin Architecture Affects DNA Break Formation and Repair

International Nuclear Information System (INIS)

Singh, Sheetal; Le Hongan; Shih, S.-J.; Ho, Bay; Vaughan, Andrew T.

2010-01-01

Purpose: Chromatin-modifying compounds that inhibit the activity of histone deacetylases have shown potency as radiosensitizers, but the action of these drugs at a molecular level is not clear. Here we investigated the effect of suberoylanilide hydroxyamic acid (SAHA) on DNA breaks and their repair and induction of rearrangements. Methods and Materials: The effect of SAHA on both clonogenic survival and repair was assessed using cell lines SCC-25, MCF7, and TK6. In order to study unique DNA double-strand breaks, anti-CD95 antibody was employed to introduce a DNA double-strand break at a known location within the 11q23 region. The effects of SAHA on DNA cleavage and rearrangements were analyzed by ligation-mediated PCR and inverse PCR, respectively. Results: SAHA acts as radiosensitizer at 1 μM, with dose enhancement factors (DEFs) at 10% survival of: SCC-25 - 1.24 ± 0.05; MCF7 - 1.16 ± 0.09 and TK6 - 1.17 ± 0.05, and it reduced the capacity of SCC-25 cells to repair radiation induced lesions. Additionally, SAHA treatment diffused site-specific fragmentation over at least 1 kbp in TK6 cells. Chromosomal rearrangements produced in TK6 cells exposed to SAHA showed a reduction in microhomology at the breakpoint between 11q23 and partner chromosomes. Conclusions: SAHA shows efficacy as a radiosensitizer at clinically obtainable levels. In its presence, targeted DNA strand breaks occur over an expanded region, indicating increased chromatin access. The rejoining of such breaks is degraded by SAHA when measured as rearrangements at the molecular level and rejoining that contributes to cell survival.

Histone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone H4 Epigenome and Reduces Akt Phosphorylation*

Science.gov (United States)

Dudakovic, Amel; Evans, Jared M.; Li, Ying; Middha, Sumit; McGee-Lawrence, Meghan E.; van Wijnen, Andre J.; Westendorf, Jennifer J.

2013-01-01

Bone has remarkable regenerative capacity, but this ability diminishes during aging. Histone deacetylase inhibitors (HDIs) promote terminal osteoblast differentiation and extracellular matrix production in culture. The epigenetic events altered by HDIs in osteoblasts may hold clues for the development of new anabolic treatments for osteoporosis and other conditions of low bone mass. To assess how HDIs affect the epigenome of committed osteoblasts, MC3T3 cells were treated with suberoylanilide hydroxamic acid (SAHA) and subjected to microarray gene expression profiling and high-throughput ChIP-Seq analysis. As expected, SAHA induced differentiation and matrix calcification of osteoblasts in vitro. ChIP-Seq analysis revealed that SAHA increased histone H4 acetylation genome-wide and in differentially regulated genes, except for the 500 bp upstream of transcriptional start sites. Pathway analysis indicated that SAHA increased the expression of insulin signaling modulators, including Slc9a3r1. SAHA decreased phosphorylation of insulin receptor β, Akt, and the Akt substrate FoxO1, resulting in FoxO1 stabilization. Thus, SAHA induces genome-wide H4 acetylation and modulates the insulin/Akt/FoxO1 signaling axis, whereas it promotes terminal osteoblast differentiation in vitro. PMID:23940046

Pahane Berlusconi : pole ma teile mingi kääbus / Aadu Hiietamm

Index Scriptorium Estoniae

Hiietamm, Aadu, 1954-

2008-01-01

Aprillis toimuvate parlamendivalimiste võidus täiesti kindel olev Itaalia ekspeaminister Silvio Berlusconi pole rahul karikatuuridega, mis rõhutavad ta lühikest kasvu. Vt. samas: Soovitus: teenige rohkem!

Weroli pankrotiprotsessi oleks saanud vältida / Hindrek Riikoja

Index Scriptorium Estoniae

Riikoja, Hindrek

2005-01-01

Aktsiaseltside Werol Tehased ja Biodiesel vahel sõlmitud lepingutest, mis on viinud Jõgeva maakohtu poolt AS-i Werol Tehased vastu algatatud pankrotimenetluseni. Vt. samas: Werol ei ole ajutise pankrotihalduriga rahul

Evaluation of the efficacy of valproic acid and suberoylanilide hydroxamic acid (vorinostat in enhancing the effects of first-line tuberculosis drugs against intracellular Mycobacterium tuberculosis

Directory of Open Access Journals (Sweden)

Martin Rao

2018-04-01

Full Text Available Background: New tuberculosis (TB drug treatment regimens are urgently needed. This study evaluated the potential of the histone deacetylase inhibitors (HDIs valproic acid (VPA and suberoylanilide hydroxamic acid (SAHA to enhance the effects of first-line anti-TB drugs against intracellular Mycobacterium tuberculosis. Methods: M. tuberculosis H37Rv cultures were exposed to VPA or SAHA over 6 days, in the presence or absence of isoniazid (INH and rifampicin (RIF. The efficacy of VPA and SAHA against intracellular M. tuberculosis with and without INH or RIF was tested by treating infected macrophages. Bactericidal activity was assessed by counting mycobacterial colony-forming units (CFU. Results: VPA treatment exhibited superior bactericidal activity to SAHA (2-log CFU reduction, while both HDIs moderately improved the activity of RIF against extracellular M. tuberculosis. The bactericidal effect of VPA against intracellular M. tuberculosis was greater than that of SAHA (1-log CFU reduction and equalled that of INH (1.5-log CFU reduction. INH/RIF and VPA/SAHA combination treatment inhibited intracellular M. tuberculosis survival in a shorter time span than monotherapy (3 days vs. 6 days. Conclusions: VPA and SAHA have adjunctive potential to World Health Organization-recommended TB treatment regimens. Clinical evaluation of the two drugs with regard to reducing the treatment duration and improving treatment outcomes in TB is warranted. Keywords: Mycobacterium tuberculosis, Adjunct host-directed therapy, Tuberculosis, Histone deacetylase inhibitors, Repurposed drugs

Tippjuhid kommunikatsiooniteenuse kvaliteedist / Kerstin Aps

Index Scriptorium Estoniae

Aps, Kerstin

2013-01-01

Kommunikatsiooniettevõte In Nomine viis läbi uuringu Eesti tippjuhtide seas, et selgitada, kui palju kasutatakse oma eesmärkide täitmiseks kommunikatsiooniteenuseid ning kuivõrd nendega rahul ollakse

Swedish solidarity / Gunnar Ljungdahl

Index Scriptorium Estoniae

Ljungdahl, Gunnar

2010-01-01

Autor ei ole rahul Läti välisministri Aivis Ronise kriitikaga Rootsi valitsuse suhtes, kes leiab, et Rootsi valitsus oleks pidanud majanduskriisi ajal sekkuma Lätis asuvate Rootsi pankade tegevusse

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

deconvolution technique · J Rajasankar Nagesh R Iyer B Yerraya Swamy N Gopalakrishnan P Chellapandi · More Details Abstract Fulltext PDF. Investigations conducted based on seismic soil-structure interaction analysis of a massive concrete ...

Efficacy and Safety Comparison Between Suberoylanilide Hydroxamic Acid and Mitomycin C in Reducing the Risk of Corneal Haze After PRK Treatment In Vivo.

Science.gov (United States)

Anumanthan, Govindaraj; Sharma, Ajay; Waggoner, Michael; Hamm, Chuck W; Gupta, Suneel; Hesemann, Nathan P; Mohan, Rajiv R

2017-12-01

This study compared the efficacy and safety of suberoylanilide hydroxamic acid (SAHA) and mitomycin C (MMC) up to 4 months in the prevention of corneal haze induced by photorefractive keratectomy (PRK) in rabbits in vivo. Corneal haze in rabbits was produced with -9.00 diopter PRK. A single application of SAHA (25 μM) or MMC (0.02%) was applied topically immediately after PRK. Effects of the two drugs were analyzed by slit-lamp microscope, specular microscope, TUNEL assay, and immunofluorescence. Single topical adjunct use of SAHA (25 μM) or MMC (0.02%) after PRK attenuated more than 95% corneal haze and myofibroblast formation (P PRK in rabbits in vivo. SAHA exhibited significantly reduced short- and long-term damage to the corneal endothelium compared to MMC in rabbits. SAHA is an effective and potentially safer alternative to MMC for the prevention of corneal haze after PRK. Clinical trials are warranted. [J Refract Surg. 2017;33(12):834-839.]. Copyright 2017, SLACK Incorporated.

Discussing nuclear energy / Rokas M. Tracevskis

Index Scriptorium Estoniae

Tracevskis, Rokas M.

2011-01-01

Venemaa ja Valgevene allkirjastasid peaminister Vladimir Putini visiidi ajal kokkuleppe uue tuumajaama ehitamiseks Valgevene ja Leedu piiri lähistele. Mõeldes Jaapanis hiljuti juhtunud tuumaõnnetusele ei ole Leedu selle otsusega rahul

Hotel protests continue / Nathan Greenhalgh

Index Scriptorium Estoniae

Greenhalgh, Nathan

2009-01-01

Leedu Hotellide ja Restoranide Liidu president ei ole rahul praeguse majandusolukorraga, kus tõstetakse käibemaksu, puuduvad otselennud suurematesse Euroopa pealinnadesse ja tahetakse kärpida Euroopa kultuuripealinn 2009 projekti eelarvet

Synthesis, characterization and gas sensing property

Indian Academy of Sciences (India)

... studies showed the Ca/P ratio of 1.63 for the HAp sample prepared by chemical process. ... School of Physical Sciences, Swami Ramanand Teerth Marathwada ... Manuscript received: 16 November 2004; Manuscript revised: 9 August 2005 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Author Affiliations. MADHURI LAKHANE1 2 RAJENDRA KHAIRNAR1 MEGHA MAHABOLE1. School of Physical Sciences, Swami Ramanand Teerth Marathwada University, Nanded (MS) 431606, India; Faculty of Mechanical Engineering, University of Maribor, Maribor 2000, Slovenia ...

USA maksumaksja nuriseb HIV-ennetusraha kulutamise üle / Anti Liiv

Index Scriptorium Estoniae

Liiv, Anti, 1946-

2004-01-01

Henry J. Kaiseri perekonna sihtasutus uuris tänavu, kuidas on USA maksumaksjad rahul nende raha kinkimisega välisriikidele HIV-vastaseks võitluseks. Autori arvates oleks ka Eestis aeg selliseid uuringuid korraldada

Clinton pingutab juutide häälte eest / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2008-01-01

Hillary Clinton teatas, et oleks valmis totaalselt hävitama Iraani, kui see ründaks Iisraeli tuumarelvaga. Juutide lobigrupid pole rahul Barack Obamaga. USA juutidest toetab H. Clintonit 48%, B. Obamat 43%

Ameeriklased muretsevad energiasõltuvuse pärast / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2006-01-01

Ajakirja Foreign Affairs ja uurimisorganisatsiooni Public Agenda küsitlusuuringu andmetel ei ole 46 protsenti ameeriklastest rahul president George W. Bushi valitsuse energiapoliitikaga. Teistest USA-s läbiviidud küsitlusuuringute tulemustest

Nuclear plant chaos

Index Scriptorium Estoniae

2010-01-01

Eesti peaminister Andrus Ansip leiab, et Läänemere regioonis on olnud liiga palju tuumajaama projekte ja Euroopa Liit peaks kaitsma energiaturgu ebaausa konkurentsi eest. Leedu ei ole Valgevene plaanitava tuumajaama asukohaga rahul

Tartu rahu oli Eesti Vabariigi välispoliitika suurim saavutus : Aleksander Kink täitis tähtsat rolli rahu sõlmimisel / Anto Raukas

Index Scriptorium Estoniae

Raukas, Anto, 1935-

2003-01-01

Petrogradi Siemens-Shuckerti dünamovabriku eestlasest asedirektori ja tehnikateadlase osast Eesti ja Vene poliitikute vahendajana rahuläbirääkimiste eel 1919. aastal; ka tema hilisematest insenerlikest ideedest Eesti energiamajanduse vallas

Ethiopian Journal of Health Sciences - Vol 22, No 2 (2012)

African Journals Online (AJOL)

Treatment of Idiopathic Clubfoot by Ponseti Technique of Manipulation and Serial Plaster Casting and its Critical Evaluation · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Sharma Pulak, MKS Swamy ...

Arnold Rüütel saab kõrgeima autasu / Silja Lättemäe

Index Scriptorium Estoniae

Lättemäe, Silja, 1952-

2008-01-01

President Arnold Rüütel saab president Toomas Hendrik Ilveselt Riigivapi ketiklassi teenetemärgi. Rahvaliit pole rahul, et A. Rüütel pole saanud ühtki riiklikku autasu oma panuse eest Eesti taasiseseisvumisse

Fulltext PDF

Indian Academy of Sciences (India)

. Pitfalls in Elementary. Physics - 4. light. Arvind Kumar. The Uncertainty Principle for Dummies. RahulSiddharthan. The Three Colour Problem. Dinoj Surendran. Think It Over. 82. Answer to 'locate the. Electrons' R Nilyananda. Information and.

Vene kriis kukutas Norma juhid / Raul Ranne

Index Scriptorium Estoniae

Ranne, Raul

1998-01-01

AS Norma vallandas ettevõtte tegevjuhi Peep Aaviksoo, sest ei olnud rahul ettevõtte tegevusega Venemaal. Tabelid: Norma aktsia on kukkunud, Norma kuukasum miinuses. Ilmunud ka: Delovõje Vedomosti, 9. sept. 1998, lk. 10

Parimate teenindusraamatute otsinguil / Katrin Aedma

Index Scriptorium Estoniae

Aedma, Katrin

2007-01-01

Klienditeenindus ning kuidas seda arendada. Tabel: Johari aken. Teenindusraamatute tutvustus: Lars-Olof NΜssén "Parem teenindamine. Kuidas enesearenduse kaudu saavutada klientide rahulolu"; Malle Karjatse "Miks klient rahul ei ole? Kuidas meeldida eesti kliendile"

Chaos returns as new Latvian Saiema convenes / Philip Birzulis

Index Scriptorium Estoniae

Birzulis, Philip

2011-01-01

Enne Läti uue seimi esimest istungit astusid 6 parlamendiliiget Valdis Zatlersi parteist välja, kuna ei olnud rahul koalitsiooni poolt esitatud ministrikandidaatidega. Seimi spiikriks valiti taas Solvita Aboltina. Statistikat praeguse seimi koosseisu kohta

Silmapaistev Juri Lotmani ja Zara Mintsi arhiiv

Index Scriptorium Estoniae

2007-01-01

Tallinna Ülikoolis paikneb rahvusvaheliselt tunnustatud semiootiku Juri Lotmani ja tema abikaasa Zara Mintsi arhiiv ja raamatukogu. Juri Lotmani poeg ja Tallinna Ülikooli Eesti Humanitaarinstituudi professor Mihhail Lotman on rahul, et arhiiv asub Eestis

Autor pole kapten Corelliga rahul / Richard Brooks

Index Scriptorium Estoniae

Brooks, Richard

2001-01-01

Menuromaani "Kapten Corelli mandoliin" autori Louis de Bernieres'i hinnanguid samanimelise filmi kohta : "Captain Corelli's Mandolin" : režissöör John Madden : Suurbritannia-Prantsusmaa-Ameerika Ühendriigid 2001

Bolu-Yedigöller Yaban Hayatı Geliştirme Sahası’nda saf meşe meşceresinde fotokapanla tespit edilen memeli türler

Directory of Open Access Journals (Sweden)

Yrd.Doç.Dr. Akif KETEN

2016-04-01

Full Text Available Son yıllarda meşe ormanlarının öneminin artması bu habitatların daha fazla araştırılma gereksinimini ortaya çıkarmıştır. Bu çalışma Bolu-Yedigöller Yaban Hayatı Geliştirme Sahası’ndaki bir saf meşe meşceresindeki memeli türlerin belirlenmesi amacıyla yapılmıştır. Yaklaşık bir yıl boyunca (Eylül 2013-Temmuz 2014 sabit noktalardan fotokapanlarla gözlemler yapılmıştır. Tespit edilen 10 memeli türe ait 1415 görüntüde 2231 yaban hayvanı bireyi sayılmıştır. Yaban domuzu, karaca ve kızıl tilki alandaki en baskın türlerdir. Meşcerede yaban hayvanları mevsimsel farklılık göstermemektedir. Daha çok beslenme davranışı görülmüştür. Türler genel olarak gececildir. Yaban hayatı bakımından zengin olan meşe meşcerelerinde sürdürülebilir yönetimin devam ettirilmesi önerilmektedir.

Savisaar : no plans to buy Estonian Railway

Index Scriptorium Estoniae

2005-01-01

Majandusminister Edgar Savisaar ei ole rahul Eesti Raudtee enamusomaniku Baltic Rail Service erastamisjärgsete kohustuste täitmisega. Eesti Raudtee nõukogu esimehe Edward Buckhardti ja BRS-i ühe omaniku Henry Posner III seisukohad

Jaan Ehlvest soovi(ta)b mudast tõusta / Jaan Ehlvest ; intervjueerinud Valeri Maksimov ; kommenteerivad: Jaak Allik, Valter Heuer, Olav Sepp

Index Scriptorium Estoniae

Ehlvest, Jaan, 1962-

1998-01-01

Intervjuu Jaan Ehlvestiga olukorrast nii Eesti kui maailma males pärast maleolümpiat Elistas, kus Eesti meeskond jäi 40. kohale ning selle tulemusega ei olnud rahul ei meeskond ega ka Eesti Maleliit

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Author Affiliations. Sushanta Dattagupta1 H R Krishnamurthy2 Rahul Pandit2 T V Ramakrishnan3 Diptiman Sen2. SN Bose National Centre for Basic Sciences, Kolkata; Indian Institute of Science, Bangalore; Banaras Hindu University, Varanasi ...

My Story: Real Stories of People Living with Thalassemia

Science.gov (United States)

... Share Compartir Real Stories from People living with Thalassemia On this Page Rahul’s Story Aaron’s Story Rahul’s ... is Rahul Kapoor, and I was born with thalassemia, a blood disorder which requires transfusions every other ...

Poliitikud kaitsevad saadikute kulude hüvitamise süsteemi / Tuuli Koch

Index Scriptorium Estoniae

Koch, Tuuli

2006-01-01

Erakondade juhtpoliitikud on rahul praeguse parlamendiliikmete kulude hüvitamise süsteemiga, mille kohaselt hüvitatakse neile kuludokumentide alusel kulutused kuni 30 protsendi ulatuses palgast. Vt. samas: Tuuli Koch. Künka kosilased. Lisa: Hea teenistus

Nickel-catalyzed direct synthesis of dialkoxymethane ethers

Indian Academy of Sciences (India)

MURUGAN SUBARAMANIAN

Nickel catalysis; alcohol; paraformaldehyde; ether; solvent-free condition. 1. Introduction ..... oxidation and Dopamine Release with Protective Effects. Against Central ... P, Ghosh A, Saha R and Saha B 2016 A Review on the. Advancement of ...

Arms or Allies? / Imants Liegis

Index Scriptorium Estoniae

Liegis, Imants

2011-01-01

Läti endine kaitseminister ei ole rahul sellega, et Euroopa Liitu ja NATO-sse kuuluv Prantsusmaa müüb Mistral-tüüpi laevu Venemaale ja leiab, et selliste otsuste tegemisel võiks arvestada teiste liikmesriikidega

Short Communication

African Journals Online (AJOL)

Antibacterial Potential of Cashew Apple (Anacardium occidentale L.) Juice Against Clinical Isolates of Staphylococcus aureus and. Streptococcus mutans. Vivek MN, Manasa M, Pallavi S, Sachidananda Swamy HC and Prashith Kekuda TR*. P. G. Department of Studies and Research in Microbiology, Sahyadri Science ...

On the upwelling off the Southern Tip and along the west coast of India

Digital Repository Service at National Institute of Oceanography (India)

Smitha, B.R.; Sanjeevan, V.N.; VimalKumar, K.G.; Revichandran, C.

downloaded from CDC-NOAA websites; in situ data were obtained from the CMLRE Data Centre; and chlo- rophyll data were retrieved from GSFC NASA. This is NIO contribution 4283. LITERATURE CITED ANTONY, M.K.; NARAYANA SWAMY, G., and SOMAYAJULU, Y.K., 2002...

African Journal of Biomedical Research - Vol 9, No 2 (2006)

African Journals Online (AJOL)

Some neuropharmacological effects of the methanolic root extract of Cissus quadrangularis in mice. EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. A.H.M Viswanatha Swamy, A.H.M Thippeswamy, D.V Manjula, C.B Mahendra Kumar.

On quantum harmonic oscillator being subjected to absolute ...

Indian Academy of Sciences (India)

On quantum harmonic oscillator being subjected to absolute potential state. SWAMI NITYAYOGANANDA. Ramakrishna Mission Ashrama, R.K. Beach, Visakhapatnam 530 003, India. E-mail: nityayogananda@gmail.com. MS received 1 May 2015; accepted 6 May 2016; published online 3 December 2016. Abstract.

Tartu rahu(tus) / Igor Gräzin

Index Scriptorium Estoniae

Gräzin, Igor, 1952-

2008-01-01

Parlamendiliikmest autor ei ole nõus president Toomas Hendrik Ilvese ettepanekuga kaotada Eesti-Vene piirilepingu preambulist viide Tartu rahule. Tartu rahu olulisim osa on Eesti tunnistamine iseseisvaks kuni aegade otsani. Vt. samas juhtkiri: Mõnus preambul. Peaminister Andrus Ansipi arvamusest

IMF gives an 'A' for effort / Ella Karapetyan

Index Scriptorium Estoniae

Karapetyan, Ella

2010-01-01

23.-29. märtsini külastas Eestit Rahvusvahelise Valuutafondi (IMF) delegatsioon. Delegatsiooni juhi Christoph Rosenbergi sõnul on IMF igati rahul Eesti eelarvepoliitikaga. Christoph Rosenbergi soovitused. Delegatsioon kohtus ka president Toomas Hendrik Ilvese ja peaminister Andrus Ansipiga

Resonance – Journal of Science Education | News

Indian Academy of Sciences (India)

78 Feature Article. What is Free Software? V Vinay · More Details Fulltext PDF. pp 79-84 Classroom. Exchange and Sign-change: The Pauli Exclusion Principle · Rahul Siddharthan · More Details Fulltext PDF. pp 85-87 Research News.

Histone Deacetylase Inhibition Downregulates Collagen 3A1 in Fibrotic Lung Fibroblasts

Directory of Open Access Journals (Sweden)

Victor J. Thannickal

2013-09-01

Full Text Available Idiopathic pulmonary fibrosis (IPF is a deadly disease characterized by chronic inflammation and excessive collagen accumulation in the lung. Myofibroblasts are the primary collagen-producing cells in pulmonary fibrosis. Histone deacetylase inhibitor (HDACi can affect gene expression, and some, such as suberoylanilide hydroxamic acid (SAHA, are US FDA approved for cancer treatment. In this study, we investigated SAHA’s effects on the expression of collagen III alpha 1 (COL3A1 in primary human IPF fibroblasts and in a murine model of pulmonary fibrosis. We observed that increased COL3A1 expression in IPF fibroblasts can be substantially reduced by SAHA treatment at the level of transcription as detected by RT-PCR; collagen III protein level was also reduced, as detected by Western blots and immunofluorescence. The deacetylation inhibitor effect of SAHA was verified by observing higher acetylation levels of both histone H3 and H4 in treated IPF cells. Chromatin immunoprecipitation (ChIP experiments demonstrated that the reduced expression of COL3A1 by SAHA is with increased association of the repressive chromatin marker, H3K27Me3, and decreased association of the active chromatin marker, H3K9Ac. In our murine model of bleomycin-induced pulmonary fibrosis, the SAHA treated group demonstrated significantly less collagen III, as detected by immunohistochemistry. Our data indicate that the HDACi SAHA alters the chromatin associated with COL3A1, resulting in its decreased expression.

Ex-diplomacy captain slags off the government / Povilas Gylys ; interviewed by Linas Jegelevicius

Index Scriptorium Estoniae

Gylys, Povilas

2011-01-01

Leedu endine välisminister ei taha poliitikasse tagasi tulla, räägib Leedu majandusest ja ei ole rahul sellega, et USA presidendi Barack Obama käest kutse saanud Leedu riigipea Dalia Grybauskaite ei sõitnud Praha kohtumisele

Kas seadus tõesti seljatab terve talupojamõistuse? / Aive Sarjas ; kommenteerinud Karina Loi, Andres Heinver

Index Scriptorium Estoniae

Sarjas, Aive

2009-01-01

Kuusalu vallas toimuvad kord nädalas kaubavahetuspäevad "Otse tootjalt tarbijale", millega on rahul nii tootjad kui ka ostjad. Veterinaar- ja Toiduamet peab seda aga seadusevastaseks, kui müüjad pole maksnud riigilõivu ja taotlenud vastavat tunnustust

Vnuk Brezhneva podajot v sud na rezhissjora / Jevgeni Tshazov

Index Scriptorium Estoniae

Tshazov, Jevgeni

2005-01-01

Vene televisiooni jaoks valminud 4-seerialise ajaloolise filmi Leonid Brezhnevist "Brezhnev" : stsenarist Valentin Tshernõhh : režissöör Sergei Snezhkin, teemadel. Brezhnevi sugulased ei ole rahul filmiga. Ära on toodud nimekiri faktidest, mis ei vastavat tegelikkusele

Uudiseid maailmast / Nele-Eva Steinfeld

Index Scriptorium Estoniae

Steinfeld, Nele-Eva

2013-01-01

Lühisõnumeid muusikamaailmast: Tan Dun nimetati UNESCO hea tahte saadikuks. Risë Stevens (1913-2013). San Francisco sümfooniaorkestri streik. Antonio Pappano pole rahul noorte ooperilauljatega. Läti Suure Muusikaauhinna võitjad. Bachi medal Peter Schreierile. Amsterdami Concertgebouw 125

Laanmäes leidub ainest Värniku mantlipärijaks / Deivil Tserp

Index Scriptorium Estoniae

Tserp, Deivil, 1968-

2007-01-01

Tanel Laanmäe ei jäänud oma esinemisega alla 20-aastaste EMil Hengelos rahule, kuid kodustel jõuproovidel virutab tulevikulootus oda kaugele. Vt. samas: Treener Toomas Merilat rõõmustab Tanel Laanmäe töökus

Dust settles around election results / Karl Haljasmets

Index Scriptorium Estoniae

Haljasmets, Karl

2011-01-01

6. märtsil Eestis toimunud parlamendivalimiste tulemustest. Ajakirjanik Abdul Turay leiab, et kõik riigikokku pääsenud erakonnad võivad oma tulemustega rahul olla. Tõnis Saartsi, Jüri Ratase, Aleksei Lotmani, Urmas Kruuse ja Jorgen Siili arvamusi

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. Ashavani Kumar. Articles written in Journal of Chemical Sciences. Volume 115 Issue 3 June 2003 pp 185-193 Physical and Theoretical. Lamellar multilayer hexadecylaniline-modified gold nanoparticle films deposited by the Langmuir-Blodgett technique · Anita Swami ...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences; Volume 125; Issue 6. Reactivity of allenylphosphonates and allenylphosphine oxides toward 9-chloroacridines and acridone- A facile route to new -substituted acridones. A Leela Siva Kumari Venu Srinivas K C Kumara Swamy. Regular Articles Volume 125 Issue 6 ...

Science, Technology and Arts Research Journal - Vol 2, No 3 (2013)

African Journals Online (AJOL)

Antibacterial Potential of Cashew Apple (Anacardium occidentale L.) Juice Against Clinical Isolates of Staphylococcus aureus and Streptococcus mutans · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. MN Vivek, M Manasa, S Pallavi, SHC Swamy, KTR Prashith ...

Differential scanning calorimetric and powder X-ray diffraction ...

Indian Academy of Sciences (India)

18) ... cells with no nuclei and cell organelles.1 The main composition of the ... properties of these molecules in a systematic manner. Most useful in this .... 1630. D Sivaramakrishna and Musti J Swamy. 40. 50. 60. 70. 80. 90. 40. 50. 60. 70. 80. 90.

Molecule Matters

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 9. Molecule Matters - A Chromium Compound with a Quintuple Bond. K C Kumara Swamy. Feature Article Volume 11 Issue 9 September 2006 pp 72-75. Fulltext. Click here to view fulltext PDF. Permanent link:

International Advisory Committee B Barish, Caltech S Ozaki, BNL S ...

Indian Academy of Sciences (India)

National Organizing Committee. Tariq Aziz, TIFR, Mumbai. N K Mondal, TIFR, Mumbai. Sunanda Banerjee, TIFR, Mumbai. B Mukhopadhyaya, HRI, Allahabad. Rahul Basu, IMSc, Chennai. G Rangarajan, IISc, Bangalore. R K Bhandari, VECC, Kolkata. S Raychaudhury, IIT, Kanpur. Debajyoti Choudhury, Delhi University S ...

Wilson, Lansing ja Hoover - Ameerika välispoliitika ja Eesti riigi tekkimine / Olavi Arens

Index Scriptorium Estoniae

Arens, Olavi, 1940-

2006-01-01

Ameerika Ühendriikide rollist Eesti ja teiste Balti riikide tekkimisel aastatel 1918-1920. On käsitletud Ameerika presidendi Woodrow Wilsoni kõnesid ning nende ja Ameerika üldist tähendust maailma välispoliitikas Versailles' rahuläbirääkimistel

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Author Affiliations. Rahul Kumar1 Ashima Khurana2. Repository of Tomato Genomics Resources, Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, India; Zakir Husain Delhi College, Botany Department, University of Delhi, New Delhi 110 002, India ...

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

, Issue 1-2. July-August 2000, pages 1-355. Special Issue: Proceedings of the Sixth Workshop on High Energy Physics Phenomenology (WHEPP-6). pp 1-2. Preface · Rahul Basu · More Details Fulltext PDF. pp 3-18. Results from atmospheric ...

"Parema elu indeks" näitab Eesti nõrkusi / Argo Ideon

Index Scriptorium Estoniae

Ideon, Argo, 1966-

2011-01-01

Majanduskoostöö- ja arenguorganisatsiooni (OECD) 50. aastapäeva puhul avaldatud 34 liikmesriigi võrdlus 11 valdkonnas näitab, et vaid 24% Eesti elanikest on oma eluga rahul. Kümnepallisüsteemis saab Eesti OECD riikide võrdluses kehvad hinded. Diagramm

Lenini kaitseks / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2002-01-01

Ilmunud ka: Vaher, Vaapo. Kokaiin Balti jaama turult: miniatuure vene kultuurist. Tallinn : Sirp, 2003, lk. 157-159. Mängufilm "Taurus" ("Telets") : stsenarist Juri Arabov : režissöör ja operaator Aleksandr Sokurov : Venemaa 2000. Autor pole rahul Lenini kujutamise kontseptsiooniga filmis

Kõrgeimad tipud on kättesaadavad vaid valituile / Nils Niitra

Index Scriptorium Estoniae

Niitra, Nils, 1975-

2006-01-01

Tartu linnavalitsuse planeeringuteenistuse ja volikogu arengu- ja planeerimiskomisjoni erinevast suhtumisest ehitusfirmade Linnaehitus ja Lion House ehitusplaanidesse püstitada kõrghooneid. Vt. samas: Jüri Saare intervjuud endise abilinnapea Kaarel Sahaga: Tigutorn lisandub mitmete õigusvastaste ehitiste ritta; Jüri Saar. Linnavolinikud toimuvaga rahul

Comparison of FLOWTRAN predictions of onset of significant voiding (OSV) to Savannah River Heat Transfer Laboratory subcooled boiling flow instability measurements, Part 1

International Nuclear Information System (INIS)

Laurinat, J.E.

1988-10-01

The onset of flow instability (OFI) was measured in the first of a scheduled series of subcooled boiling tests at the Savannah River Heat Transfer Laboratory (HTL). This report summarizes the benchmarking of predictions of the onset of significant voiding (OSV) using Version 16 of the FLOWTRANΩ reactor limits code against the HTL measurements. This study confirms that, for this series of HTL subcooled boiling tests, the Saha-Zuber OSV correlation was a conservative indicator of OFI for Peclet numbers between 30,000 and 80,000. The Saha-Zuber correlation was not a conservative indicator of OFI for Peclet numbers below 30,000. A conservative bound to the Saha-Zuber correlation (the Saha-Zuber constant Stanton number criterion -- 30%) was agreed to at a meeting of SRL, DOE, and the DOE EH and DP review panels. This bound was a conservative indicator of OFI for all measurements in this study

Altering histone acetylation status in donor cells with suberoylanilide hydroxamic acid does not affect dog cloning efficiency.

Science.gov (United States)

Kim, Min Jung; Oh, Hyun Ju; Kim, Geon A; Suh, Han Na; Jo, Young Kwang; Choi, Yoo Bin; Kim, Dong Hoon; Han, Ho Jae; Lee, Byeong Chun

2015-10-15

Although dog cloning technology has been applied to conservation of endangered canids, propagation of elite dogs, and production of transgenic dogs, the efficiency of cloning is still very low. To help overcome this problem, we evaluated the effect of treating donor cells with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on dog cloning efficiency. Relative messenger RNA expressions of the bax1/bcl2 ratio and Dnmt1 in fibroblasts treated with different concentrations (0, 1, 10, 50 μM) of SAHA and durations (0, 20, 44 hours) were compared. Treatment with 1 μM for 20 hours showed significantly lower bax1/bcl2 and Dnmt1 transcript abundance. Acetylation of H3K9 was significantly increased after SAHA treatment, but H4K5, H4K8 and H4K16 were not changed. After SCNT using control or donor cells treated with SAHA, a total of 76 and 64 cloned embryos were transferred to seven and five recipients, respectively. Three fetuses were diagnosed in both control and SAHA-treated groups by ultrasonography 29 days after the embryo transfer, but there was no significant difference in the pregnancy rate (4.2% vs. 4.3%). In conclusion, although SAHA treatment as used in this study significantly decreased bax1/bcl2 and Dnmt1 transcripts of donor nuclei, as well as increased H3 acetylation, it was not enough to increase in vivo developmental competence of cloned dog embryos. Copyright © 2015 Elsevier Inc. All rights reserved.

77 FR 20782 - Circular Welded Carbon Steel Pipes and Tubes From Thailand: Preliminary Results of Antidumping...

Science.gov (United States)

2012-04-06

... Memorandum. We revised Pacific Pipe's financial expense ratio calculation to be based on its consolidated financial statements rather than its unconsolidated financial statements as reported. We increased Pacific... Saha Thai's financial expense ratio to zero. For more information on the changes to Saha Thai's COP...

Resonance – Journal of Science Education | Indian Academy of ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Chandan Saha. Articles written in Resonance – Journal of Science Education. Volume 17 Issue 8 August 2012 pp 768-778 General Article. Dissymmetry and Asymmetry - A Hopeless Conflict in Chemical Literature · Chandan Saha Suchandra Chakraborty.

Resonance – Journal of Science Education | Indian Academy of ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 1. Babylonian Pythagoras' Theorem, the Early History of Zero and a Polemic on the Study of the History of Science. Rahul Roy. General Article Volume 8 Issue 1 January 2003 pp 30-40 ...

Appointment of Ignalina negotiator marred by intense political bickering

Index Scriptorium Estoniae

2008-01-01

Aleksandras Abisala määrati Leedu valitsuse poolt läbirääkijaks Euroopa Komisjoniga. Abisala püüab tõestada, et Ignalina tuumajaama sulgemise probleem on terve Euroopa probleem. Mõned poliitikud pole rahul Abisala valimisega läbirääkijaks

Laine Jänes asus kultuuripealinna juhti Mikko Fritzet toetama / Mari Kodres

Index Scriptorium Estoniae

Kodres, Mari

2010-01-01

Kultuuriminister Laine Jänes nimetas kultuuripealinna Tallinn 2011 sihtasutuse juhtide Mikko Fritze ja Jaanus Mutli ning programmiosakonna juhi Jaanus Rohumaa esinemist valitsuskabinetis usaldusväärseks ning jäi rahule programmi tutvustamisega. Väidetavalt tahetakse sihtasutuse juhti Mikko Fritzet välja vahetada

Ohm's Law, Kirchoff's Law and the Drunkard's Walk The Drunkard's ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 2; Issue 12. Ohm's Law, Kirchoff's Law and the Drunkard's Walk The Drunkard's Walk. Rahul Roy. General Article Volume 2 Issue 12 December 1997 pp 33-38. Fulltext. Click here to view fulltext PDF. Permanent link:

Ohm's Law, Kirchoff's Law and the Drunkard's Walk

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 2; Issue 11. Ohm's Law, Kirchoff's Law and the Drunkard's Walk Related Electrical Networks. Rahul Roy. General Article Volume 2 Issue 11 November 1997 pp 36-47. Fulltext. Click here to view fulltext PDF. Permanent link:

to view fulltext PDF

Indian Academy of Sciences (India)

deba@theory.saha.ernet.in. Banik Sarmistha, Saha Institute of Nuclear Physics, ... Biswas S K, Department of Theoretical Physics, IACS, Jadavpur, Kolkata 700 032. Bordalo Paula, LIP, Av. Elios Garcia 14, 1000 .... Nakagawa Hisao, Institute of Nuclear Sciences, Nara University, 1500 Misasagi-Cho,. Nara 631-8502, Japan.

How do Plants Absorb Nutrients from the Soil? - Study of Nutrient ...

Indian Academy of Sciences (India)

Logo of the Indian Academy of Sciences. Indian Academy of Sciences. Home · About ... Home; Journals; Resonance – Journal of Science Education; Volume 3; Issue 7. How do Plants Absorb Nutrients from the ... Author Affiliations. G Sivakumar Swamy1. Department of Botany, Karnatak University, Dharwad 580 003, India.

S Basavaraja

Indian Academy of Sciences (India)

Volume 33 Issue 1 February 2010 pp 1-6 Thin Films and Nanomatter. Lead adsorption study on combustion derived -Fe2O3 surface ... Barium ferrite nanoparticles prepared by self-propagating low-temperature combustion method and its characterization · P M Prithviraj Swamy S Basavaraja Vijayanand Havanoor N V ...

Untitled

Indian Academy of Sciences (India)

Waring's problem, on I (k) in, and an analogous function (Chowla), 269. Wood, lignin and wood-cellulose, X-ray studies (Nilakantan), 166. X-ray analysis of the structure of a fibrous modification of tourmaline (Swamy and Iyengar), 419. X-ray studies of wood, lignin and wood-cellulose (Nilakantan), 166.

compounds with N=N, C≡C or conjugated double-bonded systems

Indian Academy of Sciences (India)

Unusual products in the reactions of phosphorus(III) compounds with. N=N, C≡C or conjugated double-bonded systems. K C KUMARA SWAMY,* E BALARAMAN, M PHANI PAVAN, N N BHUVAN KUMAR,. K PRAVEEN KUMAR and N SATISH KUMAR. School of Chemistry, University of Hyderabad, Hyderabad 500 046.

Prantsuse sotsialistid pole ikka Royaliga rahul / Hent Kalmo

Index Scriptorium Estoniae

Kalmo, Hent, 1979-

2007-01-01

Prantsusmaa sotsialistide presidendikandidaat Segolene Royal kutsus oma valimiskampaanias osalema partei nn. vana kaardiväe. Paljud sotsialistide juhid on Royali seisukohti pidanud liiga parempoolseiks, Royal on püüdnud oma valijaid veenda oma sotsialistlikus maailmavaates

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Sadhana. MICHEL J CERVANTES. Articles written in Sadhana. Volume 41 Issue 11 November 2016 pp 1311-1320. Transient pressure measurements at part load operating condition of a high head model Francis turbine · RAHUL GOYAL CHIRAG TRIVEDI B K GANDHI MICHEL J CERVANTES OLE G ...

Anuradha Misra

Indian Academy of Sciences (India)

Anuradha Misra. Articles written in Pramana – Journal of Physics. Volume 63 Issue 6 December 2004 pp 1367-1379. Working group report: Quantum chromodynamics · Prakash Mathewes Rahul Basu D Indumathi E Laenen Swapan Majhi Anuradha Misra Asmita Mukherjee W Vogelsang · More Details Abstract Fulltext PDF.

Experimental study of average void fraction in low-flow subcooled boiling

International Nuclear Information System (INIS)

Sun Qi; Wang Xiaojun; Xi Zhao; Zhao Hua; Yang Ruichang

2005-01-01

Low-flow subcooled void fraction in medium pressure was investigated using high-temperature high-pressure single-sensor optical probe in this paper. And then average void fraction was obtained through the integral calculation of local void fraction in the cross-section. The experimental data were compared with the void fraction model proposed in advance. The results show that the predictions of this model agree with the data quite well. The comparisons of Saha and Levy models with low-flow subcooled data show that Saha model overestimates the experimental data distinctively, and Levy model also gets relatively higher predictions although it is better than Saha model. (author)

Studies on Archaean Dharwar Tectonic Province 433

Indian Academy of Sciences (India)

age data on the geological evolution of southern India; Proc. workshop on deep continental crust of. South India, LPI Tech. Tept. No. 88-06, pp. 181-183. Viswanatha M. N, Ramakrishnan M and Swami Nath J 1982 Angular unconformity between Sargur and. Dharwar supracrustals in Shigegudda, Karnataka cration, South ...

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Sadhana. Nagesh R Iyer. Articles written in Sadhana. Volume 32 Issue 3 June 2007 pp 215-234. SSI analysis of a massive concrete structure based on a novel convolution/deconvolution technique · J Rajasankar Nagesh R Iyer B Yerraya Swamy N Gopalakrishnan P Chellapandi · More Details Abstract ...

A cognitive linguistic exploration of metaphors within the WATER ...

African Journals Online (AJOL)

A cognitive linguistic exploration of metaphors within the WATER frame in Swami Vivekananda's Complete Works : A corpus-driven study in light of conceptual metaphor theory. ... Which terms to search for specifically was determined after a manual reading of a sample from the Complete Works. The data were then tagged ...

Development Programs and the Maoist Insurgency in Andhra Pradesh and Chhattisgarh: A Comparative Analysis

Science.gov (United States)

2012-12-01

Praveen Swami, “India’s Counter-insurgency Conundrum,” Hindu, July 23, 2010, http://www.hindu.com/2010/07/23/stories/2010072354911200.htm. 27 Varun Vira... Praveen . “India’s Counter-Insurgency Conundrum.” Hindu, July 23, 2010. Taber, Robert. War of the Flea: The Classic Study of Guerilla Warfare. Dulles

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Sadhana. P K Sharma. Articles written in Sadhana. Volume 39 Issue 6 December 2014 pp 1425-1446. Simulation of experimental breakthrough curves using multiprocess non-equilibrium model for reactive solute transport in stratified porous media · Deepak Swami P K Sharma C S P Ojha · More Details ...

to view fulltext PDF

Indian Academy of Sciences (India)

srimathi

Adhikari Sucheta, NRS Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar,. Kolkata 700 064, India (sucheta@hp1.saha.ernet.in). Ansari M Afzal, Department of Physics, Aligarh Muslim University, Aligarh 202 002, India. Telex: 564-230 AMU IN. Arumugam P, Department of Physics, M. S. University, Tirunelveli ...

78 FR 21105 - Circular Welded Carbon Steel Pipes and Tubes From Thailand: Preliminary Results of Antidumping...

Science.gov (United States)

2013-04-09

.../exporters of the subject merchandise, Saha Thai Steel Pipe (Public) Company, Ltd. (Saha Thai), and Pacific Pipe Company Limited (Pacific Pipe). The period of review (POR) is March 1, 2011, through February 29...) Company, Ltd 0.00 Pacific Pipe Company Limited * * No shipments or sales subject to this review. The firm...

Preparation of diamond like carbon thin film on stainless steel and ...

Indian Academy of Sciences (India)

Author Affiliations. Kamlesh Kumari1 S Banerjee2 T K Chini2 N R Ray3. Amity Institute of Nanotechnology, Amity University, Noida 201 303, India; Surface Physics Division, Saha Institute of Nuclear Physics, Kolkata 700 064, India; Plasma Physics Division, Saha Institute of Nuclear Physics, Kolkata 700 064, India ...

Enhancement of Radiation Response in Osteosarcoma and Rhabomyosarcoma Cell Lines by Histone Deacetylase Inhibition

International Nuclear Information System (INIS)

Blattmann, Claudia; Oertel, Susanne; Ehemann, Volker

2010-01-01

Purpose: Histone deacetylase inhibitors (HDACIs) can enhance the sensitivity of cells to photon radiation treatment (XRT) by altering numerous molecular pathways. We investigated the effect of pan-HDACIs such as suberoylanilide hydroxamic acid (SAHA) on radiation response in two osteosarcoma (OS) and two rhabdomyosarcoma (RMS) cell lines. Methods and Materials: Clonogenic survival, cell cycle analysis, and apoptosis were examined in OS (KHOS-24OS, SAOS2) and RMS (A-204, RD) cell lines treated with HDACI and HDACI plus XRT, respectively. Protein expression was investigated via immunoblot analysis, and cell cycle analysis and measurement of apoptosis were performed using flow cytometry. Results: SAHA induced an inhibition of cell proliferation and clonogenic survival in OS and RMS cell lines and led to a significant radiosensitization of all tumor cell lines. Other HDACI such as M344 and valproate showed similar effects as investigated in one OS cell line. Furthermore, SAHA significantly increased radiation-induced apoptosis in the OS cell lines, whereas in the RMS cell lines radiation-induced apoptosis was insignificant with and without SAHA. In all investigated sarcoma cell lines, SAHA attenuated radiation-induced DNA repair protein expression (Rad51, Ku80). Conclusion: Our results show that HDACIs enhance radiation action in OS and RMS cell lines. Inhibition of DNA repair, as well as increased apoptosis induction after exposure to HDACIs, can be mechanisms of radiosensitization by HDACIs.

Archaeological excavations in the counties of Harjumaa and Raplamaa / Gurly Vedru, Raili Allmäe, Kadri Nigulas

Index Scriptorium Estoniae

Vedru, Gurly, 1970-

2009-01-01

Kaevamistest Harjumaal Saha külas ja Raplamaal Kalbu külas. Sahas uuriti keskaegset kivist kabeliaeda. Kalbu külas toimusid päästekaevamised Räägu-Uueotsa talu alal paikneval kalmel. Leitud müntide põhjal võib oletada, et Kalbu kalmesse maeti 17. sajandil ning 18. saj. algul

Kliendisuhte juhtimine algab kliendi tundmisest / Philip Kotler

Index Scriptorium Estoniae

Kotler, Philip

2003-01-01

Peatükk P. Kotleri raamatust "Turundusvaatenurgad Ast Zni". Autori sõnul seisneb kliendisuhte turundus riist- ja tarkvara hankimises, mis võimaldab ettevõttel saada detailset informatsiooni igast kliendist, mida saab omakorda kasutada paremaks turundustegevuseks. Põhjustest, miks pole ettevõtted kliendisuhte juhtimise süsteemide rakendamise tulemustega rahul

RE-SONA-NC-E--I -No-v-em-ber-19-9-7

Indian Academy of Sciences (India)

Vineeta Bal and Satyajit Rath. Know Your Personal Computer You and Your PC. 5 K Ghoshal. GENERAL ARTICLES. , .) The Sun - Maior Energy Resource for the Future. Benny Joseph, K G Gopichandran and V K Vaidyan. - ~ Ohm's Law, Kirchoffs Law and the. Drunkard's Walk. Related Electrical Networks. RahulRoy.

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Earth System Science. Rahul Choudhury. Articles written in Journal of Earth System Science. Volume 125 Issue 7 October 2016 pp 1365-1377. Thermogravimetric and model-free kinetic studies on CO2 gasification of low-quality, high-sulphur Indian coals · Tonkeswar Das Ananya Saikia ...

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Sadhana. ANUJ ABRAHAM. Articles written in Sadhana. Volume 43 Issue 3 March 2018 pp 41. Reduced order modelling and predictive control of multivariable nonlinear process · ANUJ ABRAHAM N PAPPA DANIEL HONC RAHUL SHARMA · More Details Abstract Fulltext PDF. In this paper, an efficient ...

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Sadhana. DANIEL HONC. Articles written in Sadhana. Volume 43 Issue 3 March 2018 pp 41. Reduced order modelling and predictive control of multivariable nonlinear process · ANUJ ABRAHAM N PAPPA DANIEL HONC RAHUL SHARMA · More Details Abstract Fulltext PDF. In this paper, an efficient ...

Resonance – Journal of Science Education | Indian Academy of ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 4; Issue 6. Drought Signaling in Plants. G Sivakumar Swamy. General Article Volume 4 Issue 6 June 1999 pp 34-44. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/004/06/0034-0044. Author Affiliations.

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. K Senthil Kumar. Articles written in Journal of Chemical Sciences. Volume 114 Issue 4 August 2002 pp 367-377. Chemistry of selected cyclic P(III) compounds possessing a P-Cl bond · K C Kumara Swamy Sudha Kumaraswamy Praveen Kommana N Satish Kumar K Senthil ...

B P Radhakrishna (April 1918–January 2012)

Indian Academy of Sciences (India)

IAS Admin

Charles Darwin, B G L Swamy and Madame Curie. BPR was elected Fellow of the IASc (1956), INSA (1972), the Geological Society of London. (1986) and the Geological Society of America (1988). He was awarded the National Mineral. Award by the Government of India (1971), the Rajyotsava Award of Government of ...

Preparation and characterization of rubbery epoxy/multiwall carbon nanotubes composites using amino acid salt assisted dispersion technique

Directory of Open Access Journals (Sweden)

S. B. Jagtap

2013-04-01

Full Text Available Epoxy/multiwall carbon nanotubes (MWCNT composites were prepared using sodium salt of 6-aminohexanoic acid (SAHA modified MWCNT and its effect properties of related composites were investigated. The composite prepared using a polar solvent, tetrahydrofuran exhibits better mechanical properties compared to those prepared using less polar solvent and without using solvent. The tensile properties and dynamic storage modulus was found to be increased as a result of modification of MWCNT with SAHA. This improvement in the tensile properties and dynamic mechanical properties of epoxy/MWCNT composite is a combined effect of cation-π interaction and chemical bonding. Fourier transform infrared spectroscopy (FTIR and Raman spectroscopy were used to explain cation-π interaction between SAHA with MWCNT and chemical bonding of SAHA with epoxy resin. The effect of modification of MWCNT on morphology of a nanocomposite was confirmed by using scanning electron microscopy (SEM and transmission electron microscopy (TEM. The present approach does not disturb the ! electron clouds of MWCNT as opposed to chemical functionalization strategy.

Fulltext PDF

Indian Academy of Sciences (India)

Noam Chomsky titled 'Language and Freedom'. Rahul describes the principal universal aspects of music, and the difficulties of defining objectively the subjective qualities of pleasant melodies and sounds on the one hand and jarring ones on the other. He concentrates on Western classical music, and in particular on the ...

NATO eskaader on Admiral Pitka juhtimisel teel Tallinna / Hannes Krause

Index Scriptorium Estoniae

Krause, Hannes

2005-01-01

Eesti mereväe lipulaeva Admiral Pitka komandör Jüri Saska tõstab esile laeva meeskonna uusi praktilisi kogemusi, mis on saadud viimastel kuudel NATO miinitõrjeeskaadri staabilaeva meeskonna rollis. Eskaadri ülem kaptenleitnant Nico Vasseur on Eesti mereväelaste tööga väga rahul

Simmi "Head käed" tuli, nägi ja võitis / Triin Tael

Index Scriptorium Estoniae

Tael, Triin

2002-01-01

Berliini 52. filmifestivali "Panorama Special" kavas olnud Peeter Simmi Eesti-Läti ühisfilm "Head käed" saavutas hea publikuedu ning jagas sloveenlase Maja Weiss'i filmiga "Piirivalvur" Manfred Salzgeberi auhinda, mis on mõeldud subtiitrite tegemiseks filmi levitamisel euroopa ekraanidele. P. Simm on rahul ja plaanib uut filmi

Fulltext PDF

Indian Academy of Sciences (India)

A Pedagogical Study of Cooling of a Granualar Gas. Keywords. Granular gas, cooling, Haff's law, inelastic collisions. Rahul Makhijani1, Praveen. Pathak2 and Vijay A Singh2. 1 Department of Electrical. Engineering, IIT, Bombay,. Powai, Mumbai 400 076, India. 2 Homi Bhabha Centre for. Science Education (TIFR), V N.

Resonance – Journal of Science Education | Indian Academy of ...

Indian Academy of Sciences (India)

Annual Meetings · Mid Year Meetings · Discussion Meetings · Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 11. A Pedagogical Study of Cooling of a Granualar Gas. Rahul Makhijani Praveen Pathak Vijay ...

Mineralogical and chemical characteristics of newer dolerite dyke ...

Indian Academy of Sciences (India)

Dunn and Dey 1942; Saha 1948, 1952; Saha et al. 1972, 1973). ... nuclei of the Indian landmass (Basu et al. 1981;. Goswami ... Geochemistry. In order to get an idea about petrogenetic process ...... Greenough John D, Fryer Brian J and Robinson Paul T ... 643–660. Mc Mullin David W A, Barr Sandra M and Raeside Robert.

The histone deacetylase inhibitor, Vorinostat, represses hypoxia inducible factor 1 alpha expression through translational inhibition.

Directory of Open Access Journals (Sweden)

Darren M Hutt

Full Text Available Hypoxia inducible factor 1α (HIF-1α is a master regulator of tumor angiogenesis being one of the major targets for cancer therapy. Previous studies have shown that Histone Deacetylase Inhibitors (HDACi block tumor angiogenesis through the inhibition of HIF-1α expression. As such, Vorinostat (Suberoylanilide Hydroxamic Acid/SAHA and Romidepsin, two HDACis, were recently approved by the Food and Drug Administration (FDA for the treatment of cutaneous T cell lymphoma. Although HDACis have been shown to affect HIF-1α expression by modulating its interactions with the Hsp70/Hsp90 chaperone axis or its acetylation status, the molecular mechanisms by which HDACis inhibit HIF-1α expression need to be further characterized. Here, we report that the FDA-approved HDACi Vorinostat/SAHA inhibits HIF-1α expression in liver cancer-derived cell lines, by a new mechanism independent of p53, prolyl-hydroxylases, autophagy and proteasome degradation. We found that SAHA or silencing of HDAC9 mechanism of action is due to inhibition of HIF-1α translation, which in turn, is mediated by the eukaryotic translation initiation factor--eIF3G. We also highlighted that HIF-1α translation is dramatically inhibited when SAHA is combined with eIF3H silencing. Taken together, we show that HDAC activity regulates HIF-1α translation, with HDACis such as SAHA representing a potential novel approach for the treatment of hepatocellular carcinoma.

Phase I/II trial of vorinostat (SAHA) and erlotinib for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations after erlotinib progression.

Science.gov (United States)

Reguart, Noemi; Rosell, Rafael; Cardenal, Felipe; Cardona, Andres F; Isla, Dolores; Palmero, Ramon; Moran, Teresa; Rolfo, Christian; Pallarès, M Cinta; Insa, Amelia; Carcereny, Enric; Majem, Margarita; De Castro, Javier; Queralt, Cristina; Molina, Miguel A; Taron, Miquel

2014-05-01

Vorinostat or suberoylanilide hydroxamic acid (SAHA) is a novel histone deacetylase inhibitor with demonstrated antiproliferative effects due to drug-induced accumulation of acetylated proteins, including the heat shock protein 90. We prospectively studied the activity of vorinostat plus erlotinib in EGFR-mutated NSCLC patients with progression to tyrosine kinase inhibitors. We conducted this prospective, non-randomized, multicenter, phase I/II trial to evaluate the maximum tolerated dose, toxicity profile and efficacy of erlotinib and vorinostat. Patients with advanced NSCLC harboring EGFR mutations and progressive disease after a minimum of 12 weeks on erlotinib were included. The maximum tolerated dose of vorinostat plus erlotinib was used as recommended dose for the phase II (RDP2) to assess the efficacy of the combination. The primary end point was progression-free-survival rate at 12 weeks (PFSR12w). Pre-treatment plasma samples were required to assess T790M resistant mutation. A total of 33 patients were enrolled in the phase I-II trial. The maximum tolerated dose was erlotinib 150 mg p.o., QD, and 400mg p.o., QD, on days 1-7 and 15-21 in a 28-day cycle. Among the 25 patients treated at the RDP2, the most common toxicities included anemia, fatigue and diarrhea. No responses were observed. PFSR12w was 28% (IC 95%: 18.0-37.2); median progression-free survival (PFS) was 8 weeks (IC 95%: 7.43-8.45) and overall survival (OS) 10.3 months (95% CI: 2.4-18.1). Full dose of continuous erlotinib with vorinostat 400mg p.o., QD on alternative weeks can be safely administered. Still, the combination has no meaningful activity in EGFR-mutated NSCLC patients after TKI progression. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Sõjaga kümnendasse aastasse: Afganistan otsib juba tõsiselt rahu / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2010-01-01

Autor analüüsib Afganistani presidendi poolt peetavaid rahuläbirääkimisi. Kui seni on Afganistani president Hamid Karzai otsinud võimalusi rääkida Talibani varjanud hõimupealikega, siis nüüd peetakse kõnelusi Talibani kõige raevukama rühmituse, nn. Haqqani võrgustikuga

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Volume 40 Issue 4 October 2015 pp 819-828 Articles. Flux balance analysis of genome-scale metabolic model of rice (Oryza sativa): Aiming to increase biomass · Rahul Shaw Sudip Kundu · More Details Abstract Fulltext PDF. Due to socio-economic reasons, it is essential to design efficient stress-tolerant, more nutritious, ...

On Ancient Babylonian Algebra and Geometry

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 8. On Ancient Babylonian Algebra and Geometry. Rahul Roy. General Article Volume 8 Issue 8 August 2003 pp 27-42. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/008/08/0027-0042. Keywords.

The lighter side of gravity (How Swami Gurutvananda received ...

Indian Academy of Sciences (India)

cident happened three centuries before Issac Newton, that is in times when the English language had not reached our shores and Sanskrit still enjoyed the status of language of knowledge. Now it so .... 'Surely, you can point out the lack of.

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Articles written in Journal of Earth System Science. Volume 118 Issue 4 August 2009 pp 405-412. Magnetic anomalies of offshore Krishna-Godavari Basin, eastern continental margin of India · K V Swamy I V Radhakrishna Murthy K S Krishna K S R Murthy A S Subrahmanyam M M Malleswara Rao · More Details Abstract ...

On Integrated Social and QoS Trust-Based Routing in Delay Tolerant Networks

Science.gov (United States)

2011-05-15

according to our protocol. This leads to Tik(t + At) < Tmin because /?j + f32 = 1 and T, fc (t) < Tmin is given (in the if part). Therefore, it is...Disruption-Tolerant Networking," IEEE INFOCOM 2006. Barcelona . Spain. April 2006, pp. 1-11. [3] J.H. Cho, A. Swami and I.R. Chen, "Modeling and

Influence of seeding on crystallization behaviour of BaNaB9 glasses

Indian Academy of Sciences (India)

Administrator

Influence of seeding on crystallization behaviour of BaNaB9. O15 glasses. RAHUL VAISH and K B R VARMA*. Materials Research Centre, Indian Institute of Science, Bangalore 560 012, India. MS received 18 August 2008. Abstract. Transparent BaNaB9O15 (BNBO) glasses were fabricated via the conventional melt- ...

Histone deacetylase inhibition sensitizes osteosarcoma to heavy ion radiotherapy

International Nuclear Information System (INIS)

Blattmann, Claudia; Oertel, Susanne; Thiemann, Markus; Dittmar, Anne; Roth, Eva; Kulozik, Andreas E.; Ehemann, Volker; Weichert, Wilko; Huber, Peter E.; Stenzinger, Albrecht; Debus, Jürgen

2015-01-01

Minimal improvements in treatment or survival of patients with osteosarcoma have been achieved during the last three decades. Especially in the case of incomplete tumor resection, prognosis remains poor. Heavy ion radiotherapy (HIT) and modern anticancer drugs like histone deacetylase inhibitors (HDACi) have shown promising effects in osteosarcoma in vitro. In this study, we tested the effect of HIT and the combination of HIT and the HDACi suberoylanilide hydroxamic acid (SAHA) in a xenograft mouse model. Osteosarcoma xenografts were established by subcutaneous injection of KHOS-24OS cells and treated with either vehicle (DMSO), SAHA, HIT or HIT and SAHA. Tumor growth was determined and tumor necrosis, proliferation rate, apoptotic rate as well as vessel density were evaluated. Here, we show that the combination of HIT and SAHA induced a significant delay of tumor growth through increased rate of apoptosis, increased expression of p53 and p21 Waf1/Cip1 , inhibition of proliferation and angiogenesis compared to tumors treated with HIT only. HIT and in particular the combination of HIT and histone deacetylase inhibition is a promising treatment strategy in OS and may be tested in clinical trials

Featured Image: Bright Dots in a Sunspot

Science.gov (United States)

Kohler, Susanna

2018-03-01

This image of a sunspot, located in in NOAA AR 12227, was captured in December 2014 by the 0.5-meter Solar Optical Telescope on board the Hinode spacecraft. This image was processed by a team of scientists led by Rahul Yadav (Udaipur Solar Observatory, Physical Research Laboratory Dewali, India) in order to examine the properties of umbral dots: transient, bright features observed in the umbral region (the central, darkest part) of a sunspot. By exploring these dots, Yadav and collaborators learned how their properties relate to the large-scale properties of the sunspots in which they form for instance, how do the number, intensities, or filling factors of dots relate to the size of a sunspots umbra? To find out more about the authors results, check out the article below.Sunspot in NOAA AR 11921. Left: umbralpenumbral boundary. Center: the isolated umbra from the sunspot. Right: The umbra with locations of umbral dots indicated by yellow plus signs. [Adapted from Yadav et al. 2018]CitationRahul Yadav et al 2018 ApJ 855 8. doi:10.3847/1538-4357/aaaeba

Evaluation of Neurophysiologic and Systematic Changes during Aeromedical Evacuation and en Route Care of Combat Casualties in a Swine Polytrauma

Science.gov (United States)

2017-02-01

long range aero-medical evacuation in hypobaric environments on the physiology and organ function of injured warfighters, thus potentially and...currently ongoing. REPORTABLE OUTCOMES: Steve Chun, MD; Ashraful Haque, MD; Brittany Hazzard, BS; Saha Biswajit, MD, Martin Harssema, MD, Charles Auker...Scultetus MD; Ashraful Haque, MD; Brittany Hazzard, BS; Saha Biswajit, MD; Steve Chun, MD; Martin Harssema, MD; Charles Auker, MD, PhD; Debra Malone

2. Home 3. Journals 4. Pramana–Journal of Physics 5. Volume 63 6 ...

Indian Academy of Sciences (India)

This is the report of the QCD working sub-group at WHEPP-8 which was part of the QCD and QGP working group. Discussion and work on some aspects of resummation and parton distribution are reported. Author Affiliations. Prakash Mathewes1 Rahul Basu2 D Indumathi2 E Laenen3 Swapan Majhi4 Anuradha Misra5 ...

Fulltext PDF

Indian Academy of Sciences (India)

04 On the Glitter of a Meteor. Smart Kundassery. 15 Dust in Space. Siman Nath. 30 Babylonian Pythagoras' Theorem, the Early. 15. History of Zero and a Polemic on the Study of the History of Science. RahulRoy. 41 S Minakshisundaram: A Glimpse into his. Life and Work. S Thangavelu. 51 Lichens: A Valuable Bioresource ...

Potential Science and Technology Game Changers for the Ground Warfare of 2050: Selected Projections Made in 2017

Science.gov (United States)

2018-02-01

ARL-TR-8283 ● FEB 2018 US Army Research Laboratory Potential Science and Technology Game Changers for the Ground Warfare of 2050...Science and Technology Game Changers for the Ground Warfare of 2050: Selected Projections Made in 2017 by Alexander Kott Office of the Director...Brian Sadler Vehicle Technology Directorate, ARL Ananthram Swami Computational and Information Sciences Directorate, ARL Approved for

Rahapesu vastu võitlejad pole rahul advokaatidega / Aivar Pau

Index Scriptorium Estoniae

Pau, Aivar

2006-01-01

Rahapesu andmebüroo (RAB) tegevusest ning rahapesu ja terrorismi rahastamise tõkestamise seaduse nõuetest, mille kohaselt on advokaatidel ja notaritel kohustus teavitada rahapesu kahtlusega tehingutest

Miks 80% neist, kes tulemuspalka kasutavad, rahul ei ole

Index Scriptorium Estoniae

2004-01-01

Palgasüsteemide konsultant, Gowri päevasärkide tehase direktor Mart Kirsipuu ja palgamaksja Aavo Kokku arutlevad teemal tulemuspalk ning palgasüsteemid ettevõttes. Lisad: Motivaatorid, mis panevad inimesed tublisti tööle. Mis on Hay palgasüsteem. Vt. samas: Indrek Orro. Mis on äririski palk?; Kaspars Kaulinsh. Kui firmal läheb halvasti, peavad kannatama ka töötajad

Euroopa tootjad ei ole rahul USA survega / Ain Lember

Index Scriptorium Estoniae

Lember, Ain

2006-01-01

Seoses USA survega Euroopa turgude avanemiseks ning probleemidega Brasiilia toidukaupade ekspordi osas, kutsub üleeuroopalise põllumajandustootjate liit COPA ja põllumajandustööandjate organisatsioonide liit COGECA Euroopa valitsusjuhte üles lõpetama järeleandmiste tegemise

Ene ja Tõnis Kask pole valikuga rahul / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2003-01-01

Eesti Filmiajakirjanike Ühing andis auhinna Aasta film 2002 mängufilmile "Agent Sinikael" : režissöör Marko Raat. Viimane sai preemiaks 12 000 krooni. Auhinna rahastajad omanimelise fondi kaudu Eesti Rahvuskultuuri Fondi juures Ene ja Tõnis Kask peavad "Nimed marmortahvlil" väljajätmist isegi nominentide hulgast shokeerivaks

Haber Üretiminde Göreli Özerklik Problemi: Bir Saha Araştırması / The Relative Autonomy Problem in Newsmaking Process: A Field Research

Directory of Open Access Journals (Sweden)

Deniz Tansel İLİC

2014-09-01

Full Text Available Kültürel simgelerin üretim sürecinde görev yapan enformasyon işçilerinin özerkliği, sosyal bilimler açısından önemli bir tartışma konusudur. Üretim sürecini sadece sahiplik üzerinden değerlendiren yaklaşımlar, mülkiyet ilişkilerinin, simge üreticisinin özerklik alanını tamamen kısıtlayacağını savunurlar. Yine de, zihinsel emekleri ile çalışan simge üreticilerinin, belli oranda özerkliğe sahip olduğu iddiası sınamaya değerdir. Bu çalışmada, David Hesmondhalgh ve Mike Wayne’deki göreli özerklik vurgusundan yola çıkarak, Türkiye’de anaakım televizyon haberciliğinde bir saha araştırması yapılmıştır. Fox TV, TGRT Haber ve Kanal D’de gerçekleştirilen katılımlı gözlemlerle, birer simge üreticisi olan habercilerin, hangi oranda özerk oldukları saptanmaya çalışılmıştır. / The autonomy of information workers who work in the production process of cultural symbols is an important issue for social sciences. The approaches that evaluate the production process only in the context of ownership claim that these relationships will restrain the autonomy field of the symbol producer. Still the suggestion that symbol producers who work with their mental labours have a certain amount of autonomy is worth testing. In this study a field research is conducted in mainstream broadcasting in Turkey by using the relative autonomy emphasis in David Hesmondhalgh and Mike Wayne as a starting point. In the participant observation that is conducted in Fox TV, TGRT Haber and Kanal D Televisions it is tried to determine at what level the journalists as symbol producers are autonomous.

Studies on EOS of shock-generated argon plasmas

International Nuclear Information System (INIS)

Wang Fanhou; Jing Fuqian

2001-01-01

The equation of state for argon plasma, covering the thermodynamic states of 10000-30000 K in temperature and 0.0133-0.166 GPa in pressure, is computed using the Saha model and Debye-Huckel correction. Comparisons of the measured EOS with the calculated ones demonstrate the Saha model and Debye-Huckel correction can be used to well describe the essential behavior of argon plasma under the thermodynamic condition above-mentioned

Radiosensitization by histone deacetylase inhibition in an osteosarcoma mouse model

International Nuclear Information System (INIS)

Blattmann, C.; University Children's Hospital of Heidelberg; Thiemann, M.; Stenzinger, A.

2013-01-01

Background: Osteosarcomas (OS) are highly malignant and radioresistant tumors. Histone deacetylase inhibitors (HDACi) constitute a novel class of anticancer agents. We sought to investigate the effect of combined treatment with suberoylanilide hydroxamic acid (SAHA) and radiotherapy in OS in vivo. Methods: Clonogenic survival of human OS cell lines as well as tumor growth delay of OS xenografts were tested after treatment with either vehicle, radiotherapy (XRT), SAHA, or XRT and SAHA. Tumor proliferation, necrosis, microvascular density, apoptosis, and p53/p21 were monitored by immunohistochemistry. The CD95 pathway was performed by flow cytometry, caspase (3/7/8) activity measurements, and functional inhibition of CD95 death signaling. Results: Combined treatment with SAHA and XRT markedly reduced the surviving fraction of OS cells as compared to XRT alone. Likewise, dual therapy significantly inhibited OS tumor growth in vivo as compared to XRT alone, reflected by reduced tumor proliferation, impaired angiogenesis, and increased apoptosis. Addition of HDACi to XRT led to elevated p53, p21, CD95, and CD95L expression. Inhibition of CD95 signaling reduced HDACi- and XRT-induced apoptosis. Conclusion: Our data show that HDACi increases the radiosensitivity of osteosarcoma cells at least in part via ligand-induced apoptosis. HDACi thus emerge as potentially useful treatment components of OS. (orig.)

Radiosensitization by histone deacetylase inhibition in an osteosarcoma mouse model

Energy Technology Data Exchange (ETDEWEB)

Blattmann, C. [Olgahospital, Stuttgart (Germany). Paediatrie 5; University Children' s Hospital of Heidelberg (Germany). Dept. of Pediatric Oncology, Hematology and Immunology; Thiemann, M. [German Cancer Research Center (DKFZ), Heidelberg (Germany). Dept. of Radiotherapy, Molecular- and Translational Radiation Oncology; Stenzinger, A. [Heidelberg Univ. (Germany). Inst. of Pathology; and others

2013-11-15

Background: Osteosarcomas (OS) are highly malignant and radioresistant tumors. Histone deacetylase inhibitors (HDACi) constitute a novel class of anticancer agents. We sought to investigate the effect of combined treatment with suberoylanilide hydroxamic acid (SAHA) and radiotherapy in OS in vivo. Methods: Clonogenic survival of human OS cell lines as well as tumor growth delay of OS xenografts were tested after treatment with either vehicle, radiotherapy (XRT), SAHA, or XRT and SAHA. Tumor proliferation, necrosis, microvascular density, apoptosis, and p53/p21 were monitored by immunohistochemistry. The CD95 pathway was performed by flow cytometry, caspase (3/7/8) activity measurements, and functional inhibition of CD95 death signaling. Results: Combined treatment with SAHA and XRT markedly reduced the surviving fraction of OS cells as compared to XRT alone. Likewise, dual therapy significantly inhibited OS tumor growth in vivo as compared to XRT alone, reflected by reduced tumor proliferation, impaired angiogenesis, and increased apoptosis. Addition of HDACi to XRT led to elevated p53, p21, CD95, and CD95L expression. Inhibition of CD95 signaling reduced HDACi- and XRT-induced apoptosis. Conclusion: Our data show that HDACi increases the radiosensitivity of osteosarcoma cells at least in part via ligand-induced apoptosis. HDACi thus emerge as potentially useful treatment components of OS. (orig.)

Browse Author Index

African Journals Online (AJOL)

Items 851 - 900 of 1025 ... Sarmast, MH · Satake, Ryosuke · Saxena, Nandita A. Saxena, Rahul · Sayed, Ahmed · Sayyari, A-A · Schwartz, Myron · Sehgal, Arvind · Seifarth, FG · Sen, Sudipta · Sengar, Mamta · Setra, AE · Seyi-Olajide, Justina O. Shafei, IE · Shah, V · Shahen, Mohamad · Shahin, Mohamad · Shalaby, Mohamed S.

Juhtide õpitud abitus süveneb / Teeli Remmelg

Index Scriptorium Estoniae

Remmelg, Teeli

2006-01-01

Ilmunud ka: Delovõje Vedomosti 14. juuni lk. 10. Eesti juhtide seas läbi viidud stressiuuring näitas, et kümne aastaga on juhtidel õpitud abitus pigem suurenenud kui taandunud. Vt. samas: Mare Teichmann. Ida-Euroopas kontrollivad juhid oma elu vähem kui Lääne-Euroopas ja USAs; Välise kontrollikeskmega juhid on eluga vähem rahul

Advanced statistics for tokamak transport colinearity and tokamak to tokamak variation

International Nuclear Information System (INIS)

Riedel, K.S.

1989-03-01

This is a compendium of three separate articles on the statistical analysis of tokamak transport. The first article is an expository introduction to advanced statistics and scaling laws. The second analyzes two important problems of tokamak data---colinearity and tokamak to tokamak variation in detail. The third article generalizes the Swamy random coefficient model to the case of degenerate matrices. Three papers have been processed separately

Fulltext PDF

Indian Academy of Sciences (India)

Johnson Carl Hirschie (5) 22 (GA). Joshi A W (3) 69 (CR). Kar Guruprasad (8) 41, (9) 43 (GA). Karandikar Rajeeva L (3) 86 (CR). Kaw P K (11) 22 (GA). Konar Sushan (4) 91 (CR). Krishna Chitanya K (8) 90 (CR). Kumar Arvind (12) 10 (GA). Kumar Praveen (2) 43, (7) 61 (GA). Kumara Swamy K C (9) 72 (FA). Kunkri Samir (8) ...

1 Medium Regiment, (SAHA), SAA

African Journals Online (AJOL)

Scientia Militaria: South African Journal of Military Studies. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 16, No 4 (1986) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. 1 Medium Regiment, (S.A.H.A.), ...

On the Saha Ionization Equation

Indian Academy of Sciences (India)

the equation in terms of rate theory. ... that the said theory is said to be the harbinger of modern astro- ... Parichay (An Introduction to the Universe). Tagore ..... where |e| is the magnitude of the electron's charge and E is the electric field intensity ...

Relationship Between Chromatin Structure and Sensitivity to Molecularly Targeted Auger Electron Radiation Therapy

International Nuclear Information System (INIS)

Terry, Samantha Y.A.; Vallis, Katherine A.

2012-01-01

Purpose: The open structure of euchromatin renders it susceptible to DNA damage by ionizing radiation (IR) compared with compact heterochromatin. The effect of chromatin configuration on the efficacy of Auger electron radiotherapy was investigated. Methods and Materials: Chromatin structure was altered in MDA-MB-468 and 231-H2N human breast cancer cells by suberoylanilide hydroxamic acid (SAHA), 5-aza-2-deoxycytidine, or hypertonic treatment. The extent and duration of chromatin structural changes were evaluated using the micrococcal nuclease assay. DNA damage (γH2AX assay) and clonogenic survival were evaluated after exposure to 111 In-DTPA-hEGF, an Auger electron-emitting radiopharmaceutical, or IR. The intracellular distribution of 111 In-DTPA-hEGF after chromatin modification was investigated in cell fractionation experiments. Results: Chromatin remained condensed for up to 20 minutes after NaCl and in a relaxed state 24 hours after SAHA treatment. The number of γH2AX foci per cell was greater in MDA-MB-468 and 231-H2N cells after IR (0.5 Gy) plus SAHA (1 μM) compared with IR alone (16 ± 0.6 and 14 ± 0.3 vs. 12 ± 0.4 and 11 ± 0.2, respectively). More γH2AX foci were observed in MDA-MB-468 and 231-H2N cells exposed to 111 In-DTPA-hEGF (6 MBq/μg) plus SAHA vs. 111 In-DTPA-hEGF alone (11 ± 0.3 and 12 ± 0.7 vs. 9 ± 0.4 and 7 ± 0.3, respectively). 5-aza-2-deoxycytidine enhanced the DNA damage caused by IR and 111 In-DTPA-hEGF. Clonogenic survival was reduced in MDA-MB-468 and 231-H2N cells after IR (6 Gy) plus SAHA (1 μM) vs. IR alone (0.6% ± 0.01 and 0.3% ± 0.2 vs. 5.8% ± 0.2 and 2% ± 0.1, respectively) and after 111 In-DTPA-hEGF plus SAHA compared to 111 In-DTPA-hEGF alone (21% ± 0.4% and 19% ± 4.6 vs. 33% ± 2.3 and 32% ± 3.7). SAHA did not affect 111 In-DTPA-hEGF nuclear localization. Hypertonic treatment resulted in fewer γH2AX foci per cell after IR and 111 In-DTPA-hEGF compared to controls but did not significantly alter clonogenic

The equation of state and ionization equilibrium of dense aluminum plasma with conductivity verification

International Nuclear Information System (INIS)

Wang, Kun; Shi, Zongqian; Shi, Yuanjie; Bai, Jun; Wu, Jian; Jia, Shenli

2015-01-01

The equation of state, ionization equilibrium, and conductivity are the most important parameters for investigation of dense plasma. The equation of state is calculated with the non-ideal effects taken into consideration. The electron chemical potential and pressure, which are commonly used thermodynamic quantities, are calculated by the non-ideal free energy and compared with results of a semi-empirical equation of state based on Thomas-Fermi-Kirzhnits model. The lowering of ionization potential, which is a crucial factor in the calculation of non-ideal Saha equation, is settled according to the non-ideal free energy. The full coupled non-ideal Saha equation is applied to describe the ionization equilibrium of dense plasma. The conductivity calculated by the Lee-More-Desjarlais model combined with non-ideal Saha equation is compared with experimental data. It provides a possible approach to verify the accuracy of the equation of state and ionization equilibrium

Inhibition of Histone Deacetylases Attenuates Morphine Tolerance and Restores MOR Expression in the DRG of BCP Rats

Directory of Open Access Journals (Sweden)

Xiao-Tao He

2018-05-01

Full Text Available The easily developed morphine tolerance in bone cancer pain (BCP significantly hindered its clinical use. Increasing evidence suggests that histone deacetylases (HDACs regulate analgesic tolerance subsequent to continuous opioid exposure. However, whether HDACs contribute to morphine tolerance in the pathogenesis of BCP is still unknown. In the current study, we explored the possible engagement of HDACs in morphine tolerance during the pathogenesis of BCP. After intra-tibia tumor cell inoculation (TCI, we found that the increased expression of HDACs was negatively correlated with the decreased expression of MOR in the DRG following TCI. The paw withdrawal threshold (PWT and percentage maximum possible effects (MPEs decreased rapidly in TCI rats when morphine was used alone. In contrast, the concomitant use of SAHA and morphine significantly elevated the PWT and MPEs of TCI rats compared to morphine alone. Additionally, we found that SAHA administration significantly elevated MOR expression in the DRG of TCI rats with or without morphine treatment. Moreover, the TCI-induced increase in the co-expression of MOR and HDAC1 in neurons was significantly decreased after SAHA administration. These results suggest that HDACs are correlated with the downregulation of MOR in the DRG during the pathogenesis of BCP. Inhibition of HDACs using SAHA can be used to attenuate morphine tolerance in BCP.

Karadzhic ähvardas tribunalis lääneriike / Aadu Hiietamm

Index Scriptorium Estoniae

Hiietamm, Aadu, 1954-

2008-01-01

Sõjakuritegudes süüdistatav Bosnia serblaste endine liider Radovan Karadzhic kinnitas Haagis tribunali esimesel istungil, et ta kaitseb end ise ning tema tunnistused seavad Lääne poliitikud raskesse olukorda. R. Karadzhici väiteil lubas Bosnia sõja lõppedes USA läbirääkimiste delegatsioonijuht Richard Holbrooke, et kui ta poliitikast ja avalikust elust tagasi tõmbub, jäetakse ta rahule

COĞRAFYA EĞİTİMİNDE FİZİKİ COĞRAFYA ÖĞRETİMİ İÇİN BİR ROTA ÖNERİSİ: ÇATALCA YARIMADASI BATISI, İSTANBUL

OpenAIRE

TUNA, FİKRET; SARIKAYA, MEHMET

2014-01-01

ÖZETSaha çalışması coğrafyanın en önemli öğretim metotlarından biridir ve coğrafya bilimini ve eğitimini saha çalışmasından ayrı düşünmek mümkün değildir. Ayrıca, saha çalışmaları, coğrafya eğitimine çok çeşitli katkılar sağlamaktadır. Bu çalışmanın temel amacı, coğrafya eğitimcilerine çeşitli fiziki coğrafya konularının öğretimi ile ilgili konularda faydalanabilecekleri örnek saha çalışması güzergâhı ve inceleme sahaları ve bunlarla ilgili bilgiler sunmaktır. Böylece, ihtiyaç duyan öğretmen ...

Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity

Directory of Open Access Journals (Sweden)

Chao-Hui Yang

2017-10-01

Full Text Available Previous studies have reported that modification of histones alters aminoglycoside-induced hair cell death and hearing loss. In this study, we investigated three FDA-approved histone deacetylase (HDAC inhibitors (vorinostat/SAHA, belinostat, and panobinostat as protectants against aminoglycoside-induced ototoxicity in murine cochlear explants and in vivo in both guinea pigs and CBA/J mice. Individually, all three HDAC inhibitors reduced gentamicin (GM-induced hair cell loss in a dose-dependent fashion in explants. In vivo, however, treatment with SAHA attenuated neither GM-induced hearing loss and hair cell loss in guinea pigs nor kanamycin (KM-induced hearing loss and hair cell loss in mice under chronic models of ototoxicity. These findings suggest that treatment with the HDAC inhibitor SAHA attenuates aminoglycoside-induced ototoxicity in an acute model, but not in chronic models, cautioning that one cannot rely solely on in vitro experiments to test the efficacy of otoprotectant compounds.

Ionization equilibrium and equation of state in the solar interior

International Nuclear Information System (INIS)

Rogers, F.J.

1984-01-01

Many-body formulations of the equations of state are restated as a set of Saha-like equations. It is shown that the resulting equations are unique and convergent. These equations are similar to the usual Saha equations to the order of the Debye-Huckel theory. Higher order corrections, however, require a more general formulation. It is demonstrated that the positive free energy resulting from the interaction of unscreened particles in high orbits depletes the occupation of these states, without the introduction of shifted energy levels

The ionisation equation in a relativistic gas

International Nuclear Information System (INIS)

Kichenassamy, S.; Krikorian, R.A.

1983-01-01

By deriving the relativistic form of the ionisation equation for a perfect gas it is shown that the usual Saha equation is valid to 3% for temperatures below one hundred million Kelvin. Beyond 10 9 K, the regular Saha equation is seriously incorrect and a relativistic distribution function for electrons must be taken into account. Approximate forms are derived when only the electrons are relativistic (appropriate up to 10 12 K) and also for the ultrarelativistic case (temperatures greater than 10 15 K). (author)

Президент Эстонии повернулся лицом к России / Александр Шегедин, Сергей Строкан

Index Scriptorium Estoniae

Шегедин, Александр

2008-01-01

President Toomas Hendrik Ilves kutsus parlamenti üles loobuma Eesti-Vene piirilepingu preambulist viitega Tartu rahule. Venemaa riigiduuma välisasjade komitee esimees Konstantin Kossatšov kiitis Eesti presidenti selle ettepaneku eest. Vabariigi President töövisiidil Venemaal 27.-30.06.2008. Ülevaade artiklist ilmunud ka: Current Digest of the Post-Soviet Press, 2008, nr. 26, lk. 13-14, pealk.: Estonian president turns toward Russia

Riigiprokuratuur keelas tanker Probo Koalal Paldiskist lahkuda / Ulvar Käärt

Index Scriptorium Estoniae

Käärt, Ulvar, 1982-

2006-01-01

Riigiprokuratuur alustas tankeri Probo Koala suhtes kriminaalmenetlust. Keskkonnaministeeriumi asekantsleri Allan Gromovi sõnul näitasid analüüside tulemused suurt sarnasust nende ainetega, mis olid õnnetuse põhjuseks Elevandiluurannikul. Vt. samas: Askur Alas. Rohelised pole võimude tegutsemisega rahul; Ulvar Käärti intervjuud Greenpeace'i aktivisti Texas Constantine'iga; 35 aastaga on Greenpeace'ist saanud mõjuvõimas ühendus. Lisa: Eesti keskkonda pole ohtlikke aineid sattunud

Determination of particle concentrations in multitemperature plasmas

International Nuclear Information System (INIS)

Richley, E.; Tuma, D.T.

1982-01-01

The use of the multitemperature Saha equation (MSE) of Prigogine 1 and Patapov 2 for calculating particle concentrations in plasmas is shown to be an invalid procedure. Errors greater than one order of magnitude in the electron density in high-pressure argon and nitrogen electric arc plasmas can be easily incurred by using the multitemperature Saha equation. The alternative kinetic method for calculating concentrations is shown to be based on firm concepts. Simpliying procedures and computational techniques for calculating concentrations with the kinetic method are illustrated with examples

Spectral mixture analyses of hyperspectral data acquired using a tethered balloon

Science.gov (United States)

Chen, Xuexia; Vierling, Lee

2006-01-01

Tethered balloon remote sensing platforms can be used to study radiometric issues in terrestrial ecosystems by effectively bridging the spatial gap between measurements made on the ground and those acquired via airplane or satellite. In this study, the Short Wave Aerostat-Mounted Imager (SWAMI) tethered balloon-mounted platform was utilized to evaluate linear and nonlinear spectral mixture analysis (SMA) for a grassland-conifer forest ecotone during the summer of 2003. Hyperspectral measurement of a 74-m diameter ground instantaneous field of view (GIFOV) attained by the SWAMI was studied. Hyperspectral spectra of four common endmembers, bare soil, grass, tree, and shadow, were collected in situ, and images captured via video camera were interpreted into accurate areal ground cover fractions for evaluating the mixture models. The comparison between the SWAMI spectrum and the spectrum derived by combining in situ spectral data with video-derived areal fractions indicated that nonlinear effects occurred in the near infrared (NIR) region, while nonlinear influences were minimal in the visible region. The evaluation of hyperspectral and multispectral mixture models indicated that nonlinear mixture model-derived areal fractions were sensitive to the model input data, while the linear mixture model performed more stably. Areal fractions of bare soil were overestimated in all models due to the increased radiance of bare soil resulting from side scattering of NIR radiation by adjacent grass and trees. Unmixing errors occurred mainly due to multiple scattering as well as close endmember spectral correlation. In addition, though an apparent endmember assemblage could be derived using linear approaches to yield low residual error, the tree and shade endmember fractions calculated using this technique were erroneous and therefore separate treatment of endmembers subject to high amounts of multiple scattering (i.e. shadows and trees) must be done with caution. Including the

Assessment of impact on seafloor features in INDEX area

Digital Repository Service at National Institute of Oceanography (India)

Sharma, R.

Marine Georesources and Geotechnology,18:237–250,2000Copyright ©2000 Taylor & Francis1064-119X / 00 $12.00 1 .00 Assessment of Impact on Seafloor Features in INDEX Area RAHUL SHARMANational Institute of Oceanography,Dona Paula,Goa 403004,India...Benthic disturbance,environmental impact,photographic and subbottomdata,seafloor features. Imaging and sounding techniques are effective tools for obtaining first-hand information forassessing the baseline (undisturbed) conditions as well as the impact (disturbed...

Trust Management for Encounter-Based Routing in Delay Tolerant Networks

Science.gov (United States)

2010-05-15

8217 4 O-i 0.5 E 1.6 a 90% M 300 i / fc -vfc 0.8:0.2 « 2 1 IDS 6OO5 Oil (0, 2] mis D WS p/DS 0.5% Eo [12,24] hrs I/;.• [160,320 480] min. Below we...34 IEEE Infocom, Barcelona , Spain, Apr. 2006, pp. 1-11. [3] J.H. Cho, A. Swami and I.R. Chen, "Modeling and Analysis of Trust Management for Cognitive

In Vivo 6-([18F]Fluoroacetamido-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity

Directory of Open Access Journals (Sweden)

Nobuyoshi Fukumitsu

2018-01-01

Full Text Available Background. Histone deacetylases (HDACs regulate gene expression by changing histone deacetylation status. Neurotoxicity is one of the major side effects of cisplatin, which reacts with deoxyribonucleic acid (DNA and has excellent antitumor effects. Suberoylanilide hydroxamic acid (SAHA is an HDAC inhibitor with neuroprotective effects against cisplatin-induced neurotoxicity. Purpose. We investigated how cisplatin with and without SAHA pretreatment affects HDAC expression/activity in the brain by using 6-([18F]fluoroacetamido-1-hexanoicanilide ([18F]FAHA as a positron emission tomography (PET imaging agent for HDAC IIa. Materials and Methods. [18F]FAHA and [18F]fluoro-2-deoxy-2-D-glucose ([18F]FDG PET studies were done in 24 mice on 2 consecutive days and again 1 week later. The mice were divided into three groups according to drug administration between the first and second imaging sessions (Group A: cisplatin 2 mg/kg, twice; Group B: cisplatin 4 mg/kg, twice; Group C: cisplatin 4 mg/kg, twice, and SAHA 300 mg/kg pretreatment, 4 times. Results. The Ki value of [18F]FAHA was increased and the percentage of injected dose/tissue g (% ID/g of [18F]FDG was decreased in the brains of animals in Groups A and B. The Ki value of [18F]FAHA and % ID/g of [18F]FDG were not significantly different in Group C. Conclusions. [18F]FAHA PET clearly showed increased HDAC activity suggestive of cisplatin neurotoxicity in vivo, which was blocked by SAHA pretreatment.

Indian deep-sea environment experiment (INDEX): Monitoring the restoration of marine enviroment after artificial disturbance to simulate deep-sea mining in central Indian Basin

Digital Repository Service at National Institute of Oceanography (India)

Sharma, R.

the restoration of marine environment after artificial disturbance to simulate deep-sea mining in Central Indian Basin Guest Editor Rahul Sharma Note from guest editor A special issue on Indian Deep-sea Environment Experiment (INDEX) conducted by the scientists... in Geochemical Associations in Artificially Disturbed Deep-Sea Sediments B. Nagender Nath, G. Parthiban, S. Banaulikar, and Subhadeep Sarkar Marine Georesources and Geotechnology, 24:61–62, 2006 Copyright # Taylor & Francis Group, LLC ISSN: 1064-119X print/1521...

Underwater photography - A visual survey method

Digital Repository Service at National Institute of Oceanography (India)

Sharma, R.

Content-Type text/plain; charset=UTF-8 173 Underwater photography - A visual survey method Rahul Sharma National Institute of Oceanography, Dona Paula, Goa-403004 rsharma@nio.org Introduction “Photography as a means of observing...-sea photographs were those made by Maurice Ewing and his co-workers during cruises on Atlantis in 1940-48. Their subject was the seafloor and their method of clicking was to trigger the camera mechanically when its mounting struck bottom. This is the only...

Hyperandrogenism in female athletes with functional hypothalamic amenorrhea: a distinct phenotype

OpenAIRE

Javed, Asma; Kashyap, Rahul; Lteif, Aida N

2015-01-01

Asma Javed,1 Rahul Kashyap,2 Aida N Lteif1 1Pediatric and Adolescent Medicine, Division of Pediatric Endocrinology Mayo Clinic, Rochester, MN, USA; 2Department of Anesthesia and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA Objective: To compare the reproductive, metabolic, and skeletal profiles of young athletic women with functional hypothalamic amenorrhea (FHA) as well as clinical or biochemical hyperandrogenism (FHA-EX+HA) with body mass index matched women with FHA due to exe...

Application of generalized inverse for analysis of magnetic anomalies due to a dyke model - Some numerical experiments

Digital Repository Service at National Institute of Oceanography (India)

Rao, M.M.M.; Murty, T.V.R.; SuryaPrakash, S.; Chandramouli, P.; Murthy, K.S.R.

. Indust. Appl. Math, 11 (1963) 431-441. 10. Pedersen L B, Interpretation of potential field data – A generalised inverse approach, Geophy. Prosp. 25 (1977) 199-230. 11. Radhakrishna Murthy I V, Swamy K V & Jagannadha Rao S, Automatic inversion... generalised inverse technique in reconstruction of gravity anomalies due to a fault, Indian J. Pure. Appl. Math., 34 (2003) 31-47. 16. Ramana Murty T V, Somayajulu Y K & Murty C S, Reconstruction of sound speed profile through natural generalised inverse...

HDAC inhibitor-loaded bone cement for advanced local treatment of osteosarcoma and chondrosarcoma.

Science.gov (United States)

Tonak, Marcus; Becker, Marc; Graf, Claudine; Eckhard, Lukas; Theobald, Matthias; Rommens, Pol-Maria; Wehler, Thomas C; Proschek, Dirk

2014-11-01

The treatment of osteosarcoma, especially wide resection, is challenging. An additional local drug therapy after resection using anti-neoplastic bone cement (Polymethylmethacrylate (PMMA)) could help improve the outcome of therapy. In this study, we evaluated the effects of PMMA loaded with valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA) on the cell activity of a SaOs-2 cell culture, as well as the elution rate of the drugs out of the bone cement. In our experiments, we used the SaOs-2 osteosarcoma and the SW1353 chondrosarcoma cell line. Bone cement clots (5 g) were prepared and loaded with different drug concentrations of VPA (25 mg and 50 mg) and SAHA (1 mg, 2.5 mg and 5 mg). Two control groups were established, one with a native cement clot, the other with human mesenchymal stem cells, in order to evaluate toxicity on non tumor-cells. Cell activity was measured using an Alamar Blue assay on days 1, 2, 3, 4 and 7. The cement clots were additionally examined in a material testing unit for biomechanical and structural changes. Tumor cells showed a significant and complete reduction of activity under therapy with VPA and SAHA. Drug release of VPA was extensive between days 0 and 3 and decreased progressively to day 7. Cumulative drug concentration in the medium continuously increased. Biomechanical testing of the cement clots showed no differences in stability and architecture compared to the control group. SaOs-2 and SW1353 cells with medium from native cement clots without drug therapy presented a cell activity of 100% in all groups and during all measurements. Human mesenchymal stem cells were not significantly affected during therapy with VPA and low concentrations of SAHA. In contrast, cell activity of human mesenchymal stem cells was significantly reduced under therapy with higher concentrations of SAHA, with an approximately linear decrease between days 0-3 and a rapidly decreasing activity between days 4-7. A local cytotoxic therapy in the

Assessment of Interactions between Cisplatin and Two Histone Deacetylase Inhibitors in MCF7, T47D and MDA-MB-231 Human Breast Cancer Cell Lines - An Isobolographic Analysis.

Directory of Open Access Journals (Sweden)

Anna Wawruszak

Full Text Available Histone deacetylase inhibitors (HDIs are promising anticancer drugs, which inhibit proliferation of a wide variety of cancer cells including breast carcinoma cells. In the present study, we investigated the influence of valproic acid (VPA and suberoylanilide hydroxamic acid (SAHA, vorinostat, alone or in combination with cisplatin (CDDP on proliferation, induction of apoptosis and cell cycle progression in MCF7, T47D and MDA-MB-231 human breast carcinoma cell lines. The type of interaction between HDIs and CDDP was determined by an isobolographic analysis. The isobolographic analysis is a very precise and rigorous pharmacodynamic method, to determine the presence of synergism, addition or antagonism between different drugs with using variety of fixed dose ratios. Our experiments show that the combinations of CDDP with SAHA or VPA at a fixed-ratio of 1:1 exerted additive interaction in the viability of MCF7 cells, while in T47D cells there was a tendency to synergy. In contrast, sub-additive (antagonistic interaction was observed for the combination of CDDP with VPA in MDA-MB-231 "triple-negative" (i.e. estrogen receptor negative, progesterone receptor negative, and HER-2 negative human breast cancer cells, whereas combination of CDDP with SAHA in the same MDA-MB-231 cell line yielded additive interaction. Additionally, combined HDIs/CDDP treatment resulted in increase in apoptosis and cell cycle arrest in all tested breast cancer cell lines in comparison with a single therapy. In conclusion, the additive interaction of CDDP with SAHA or VPA suggests that HDIs could be combined with CDDP in order to optimize treatment regimen in some human breast cancers.

Inhibition of SRC-3 enhances sensitivity of human cancer cells to histone deacetylase inhibitors

Energy Technology Data Exchange (ETDEWEB)

Zou, Zhengzhi, E-mail: zouzhengzhi@m.scnu.edu.cn [MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510000 (China); Luo, Xiaoyong [Department of Oncology, The Affiliated Luoyang Central Hospital of Zhengzhou University, Luoyang 471000 (China); Nie, Peipei [KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou 510000 (China); Wu, Baoyan; Zhang, Tao; Wei, Yanchun [MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510000 (China); Wang, Wenyi [Xiamen Cancer Center, Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen 361000 (China); Geng, Guojun; Jiang, Jie [Xiamen Cancer Center, Department of Thoracic Surgery, The First Affiliated Hospital of Xiamen University, Xiamen 361000 (China); Mi, Yanjun, E-mail: myjgj_77@163.com [Xiamen Cancer Center, Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen 361000 (China)

2016-09-09

SRC-3 is widely expressed in multiple tumor types and involved in cancer cell proliferation and apoptosis. Histone deacetylase (HDAC) inhibitors are promising antitumor drugs. However, the poor efficacy of HDAC inhibitors in solid tumors has restricted its further clinical application. Here, we reported the novel finding that depletion of SRC-3 enhanced sensitivity of breast and lung cancer cells to HDAC inhibitors (SAHA and romidepsin). In contrast, overexpression of SRC-3 decreased SAHA-induced cancer cell apoptosis. Furthermore, we found that SRC-3 inhibitor bufalin increased cancer cell apoptosis induced by HDAC inhibitors. The combination of bufalin and SAHA was particular efficient in attenuating AKT activation and reducing Bcl-2 levels. Taken together, these accumulating data might guide development of new breast and lung cancer therapies. - Highlights: • Depletion of SRC-3 enhanced sensitivity of breast and lung cancer cells to HDAC inhibitors. • Overexpression of SRC-3 enhanced cancer cell resistance to HDAC inhibitors. • SRC-3 inhibitor bufalin increased cancer cell apoptosis induced by HDAC inhibitors. • Bufalin synergized with HDAC inhibitor attenuated AKT activation and reduced Bcl-2 levels in human cancer cell.

Smart Core-Shell Nanowire Architectures for Multifunctional Nanoscale Devices

Science.gov (United States)

2014-02-16

E. Spanier, S. J. May. Optical absorption in epitaxial La [sub 1?x]Sr [sub x]FeO[sub 3] thin films, Applied Physics Letters, (02 2013): 0. doi...Coster, Gregory R. Soja , Craig L. Johnson, Rahul S. Joseph, Jonathan E. Spanier. Piezoresponse through a ferroelectric nanotube wall, Applied...20.00 Received Paper Y. J. Xie, M. Torres, J. E. Spanier, S. J. May, M D. Scafetta. Optical absorption in epitaxial La [sub 1?x]Sr [sub x]FeO[sub 3

Magusaärist lahkuv Kruuda vajas raha investeeringuteks / Lauri Linnamäe

Index Scriptorium Estoniae

Linnamäe, Lauri

2007-01-01

Ärimees Oliver Kruuda müüs Kalevi ja Tere toiduainetööstused Eesti investeerimisfirmale Alta Capital, kelle esindaja Indrek Rahumaa sõnul on mõlemad pooled rahul. Finantsinspektsiooni taunivast suhtumisest müügiettevalmistuste väikeaktsionäride eest saladuses hoidmise pärast. Vt. samas: Võidusõitjast suurinvestor; Savisaar taunis Kalevi müüki; Andrus Karnau intervjuud Oliver Kruudaga: Meediaportaali nimeks saab Kalev.ee. Lisa: Alta Capital Partners; Kalevi grupi struktuur; Skandaalne K-kohuke

Using Tree Detection Algorithms to Predict Stand Sapwood Area, Basal Area and Stocking Density in Eucalyptus regnans Forest

Directory of Open Access Journals (Sweden)

Dominik Jaskierniak

2015-06-01

Full Text Available Managers of forested water supply catchments require efficient and accurate methods to quantify changes in forest water use due to changes in forest structure and density after disturbance. Using Light Detection and Ranging (LiDAR data with as few as 0.9 pulses m−2, we applied a local maximum filtering (LMF method and normalised cut (NCut algorithm to predict stocking density (SDen of a 69-year-old Eucalyptus regnans forest comprising 251 plots with resolution of the order of 0.04 ha. Using the NCut method we predicted basal area (BAHa per hectare and sapwood area (SAHa per hectare, a well-established proxy for transpiration. Sapwood area was also indirectly estimated with allometric relationships dependent on LiDAR derived SDen and BAHa using a computationally efficient procedure. The individual tree detection (ITD rates for the LMF and NCut methods respectively had 72% and 68% of stems correctly identified, 25% and 20% of stems missed, and 2% and 12% of stems over-segmented. The significantly higher computational requirement of the NCut algorithm makes the LMF method more suitable for predicting SDen across large forested areas. Using NCut derived ITD segments, observed versus predicted stand BAHa had R2 ranging from 0.70 to 0.98 across six catchments, whereas a generalised parsimonious model applied to all sites used the portion of hits greater than 37 m in height (PH37 to explain 68% of BAHa. For extrapolating one ha resolution SAHa estimates across large forested catchments, we found that directly relating SAHa to NCut derived LiDAR indices (R2 = 0.56 was slightly more accurate but computationally more demanding than indirect estimates of SAHa using allometric relationships consisting of BAHa (R2 = 0.50 or a sapwood perimeter index, defined as (BAHaSDen½ (R2 = 0.48.

Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions.

Directory of Open Access Journals (Sweden)

Bérengère Vire

Full Text Available Histone deacetylase inhibitors (HDACi have demonstrated promising therapeutic potential in clinical trials for hematological malignancies. HDACi, such as SAHA/Vorinostat, Trichostatin A, and MS-275 were found to induce apoptosis of leukemic blasts through activation of the death receptor pathway and transcriptional induction of the Tumor Necrosis Factor (TNF-related pro-apoptotic family members, TRAIL and FasL. The impact of HDACi on TNF-related costimulatory molecules such as 4-1BB ligand (4-1BBL/TNFSF9 is however not known. Following exposure to SAHA/Vorinostat, Trichostatin A, and MS-275, transcript levels were determined by real time PCR in Jurkat, Raji and U937 cells. Treatment with HDACi up-regulated TNFSF9 gene expression in the three leukemia cell lines, yet to different extend and with distinct kinetics, which did not require de novo protein synthesis and was not associated with DNAse I hypersensitive chromatin remodeling. Transcriptional activity of TNFSF9 promoter-luciferase constructs was induced up to 12 fold by HDACi, and implication of Sp1/Sp3 transcription factors binding to functional GC-box elements was evidenced by reporter gene assays, site-directed mutagenesis, and electrophoretic mobility shift assays. Functionality of modulated target genes was assessed in allogeneic mixed leukocyte reaction experiments. MS-275- and to a lesser extent Trichostatin A- and SAHA-treated Raji cells significantly up regulated T lymphocytes proliferation which was reduced by about 50% by a 4-1BB blocking recombinant protein, while MS-275- but neither Trichostatin A- nor SAHA-treated cells up-regulated IFNgamma secretion by T lymphocytes. Our results identify 4-1BBL/4-1BB as a downstream target of HDACi, especially of MS-275 anti-leukemia action in vitro. Thus, HDACi such as MS-275 displaying dual TNF-dependent proapoptotic and costimulatory activities might be favored for inclusion in HDACi-based anti-cancer therapeutic strategies.

Thermal equilibrium criteria in a nitrogen plasma

International Nuclear Information System (INIS)

Cilliers, W.A.; Hey, J.D.; Rash, J.P.S.

1975-01-01

A method for obtaining the lower electron density limit for LTE in a nitrogen plasma is described, whereby the experimentally determined ratio of the collisional-radiative ionization and recombination coefficients (S/α) is compared with the corresponding LTE value (Saha ratio). It is argued that if the electron density is increased from values of about 10 16 cm -3 , S/α should tend to the Saha ratio as LTE is approached For NII and NIII spectral lines, this is found to happen at an electron density of a few times 10 16 cm -3 when the electron temperature is about 3 eV, in good agreement with the LTE criterion of Griem. (author)

Improvements to the RADIOM non-LTE model

Science.gov (United States)

Busquet, M.; Colombant, D.; Klapisch, M.; Fyfe, D.; Gardner, J.

2009-12-01

In 1993, we proposed the RADIOM model [M. Busquet, Phys. Fluids 85 (1993) 4191] where an ionization temperature T z is used to derive non-LTE properties from LTE data. T z is obtained from an "extended Saha equation" where unbalanced transitions, like radiative decay, give the non-LTE behavior. Since then, major improvements have been made. T z has been shown to be more than a heuristic value, but describes the actual distribution of excited and ionized states and can be understood as an "effective temperature". Therefore we complement the extended Saha equation by introducing explicitly the auto-ionization/dielectronic capture. Also we use the SCROLL model to benchmark the computed values of T z.

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities.

Science.gov (United States)

Chao, Shi-Wei; Chen, Liang-Chieh; Yu, Chia-Chun; Liu, Chang-Yi; Lin, Tony Eight; Guh, Jih-Hwa; Wang, Chen-Yu; Chen, Chun-Yung; Hsu, Kai-Cheng; Huang, Wei-Jan

2018-01-01

Histone deacetylase (HDAC) is a validated drug target for various diseases. This study combined indole recognition cap with SAHA, an FDA-approved HDAC inhibitor used to treat cutaneous T-cell lymphoma (CTCL). The structure activity relationship of the resulting compounds that inhibited HDAC was disclosed as well. Some compounds exhibited much stronger inhibitory activities than SAHA. We identified two meta-series compounds 6j and 6k with a two-carbon linker had IC 50 values of 3.9 and 4.5 nM for HDAC1, respectively. In contrast, the same oriented compounds with longer carbon chain linkers showed weaker inhibition. The result suggests that the linker chain length greatly contributed to enzyme inhibitory potency. In addition, comparison of enzyme-inhibiting activity between the compounds and SAHA showed that compounds 6j and 6k displayed higher inhibiting activity for class I (HDAC1, -2, -3 and -8). The molecular docking and structure analysis revealed structural differences with the inhibitor cap and metal-binding regions between the HDAC isozymes that affect interactions with the inhibitors and play a key role for selectivity. Further biological evaluation showed multiple cellular effects associated with compounds 6j- and 6k-induced HDAC inhibitory activity. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

The epigenetic agents suberoylanilide hydroxamic acid and 5‑AZA‑2' deoxycytidine decrease cell proliferation, induce cell death and delay the growth of MiaPaCa2 pancreatic cancer cells in vivo.

Science.gov (United States)

Susanto, Johana M; Colvin, Emily K; Pinese, Mark; Chang, David K; Pajic, Marina; Mawson, Amanda; Caldon, C Elizabeth; Musgrove, Elizabeth A; Henshall, Susan M; Sutherland, Robert L; Biankin, Andrew V; Scarlett, Christopher J

2015-05-01

Despite incremental advances in the diagnosis and treatment for pancreatic cancer (PC), the 5‑year survival rate remains <5%. Novel therapies to increase survival and quality of life for PC patients are desperately needed. Epigenetic thera-peutic agents such as histone deacetylase inhibitors (HDACi) and DNA methyltransferase inhibitors (DNMTi) have demonstrated therapeutic benefits in human cancer. We assessed the efficacy of these epigenetic therapeutic agents as potential therapies for PC using in vitro and in vivo models. Treatment with HDACi [suberoylanilide hydroxamic acid (SAHA)] and DNMTi [5‑AZA‑2' deoxycytidine (5‑AZA‑dc)] decreased cell proliferation in MiaPaCa2 cells, and SAHA treatment, with or without 5‑AZA‑dc, resulted in higher cell death and lower DNA synthesis compared to 5‑AZA‑dc alone and controls (DMSO). Further, combination treatment with SAHA and 5‑AZA‑dc significantly increased expression of p21WAF1, leading to G1 arrest. Treatment with epigenetic agents delayed tumour growth in vivo, but did not decrease growth of established pancreatic tumours. In conclusion, these data demonstrate a potential role for epigenetic modifier drugs for the management of PC, specifically in the chemoprevention of PC, in combination with other chemotherapeutic agents.

Ionization equilibrium in dense plasmas

International Nuclear Information System (INIS)

Ying, R.

1987-01-01

The average degree of ionization for a strongly coupled plasma is investigated and calculated. Two widely used approaches: the Saha equation method and the Thomas-Fermi (TF) statistical atomic model are adopted to determine the degree of ionization. Both methods are modified in a number of ways to include the strong-coupling effect in the plasma. In the Saha equation approach, the strong-coupling effects are introduced through: (i) a replacement of the Coulomb potential by a screened Debye potential; (ii) adoption of the Planck-Larkin partition function; (iii) description of the electron component by Fermi-Dirac statistics. The calculated degree of ionization exceeds that obtained from the original Saha equation, exhibits a minimum as a function of the density and shows an abrupt phase transition from weakly ionized to a fully ionized state. The zero-temperature TF model for compressed ions and the finite-temperature TF model for ions are investigated for the first time. In order to take into account the strong-coupling effect in a systematic way, a strong-coupling TF model is set up. Favorable results with the relatively simple approximations indicate that the newly established strong-coupling TF model is a more systematic and physically consistent approach

Saha equation, single and two particle states

International Nuclear Information System (INIS)

Kraeft, W.D.; Girardeau, M.D.; Strege, B.

1990-01-01

Single and two particle porperties in dense plasma are discussed in connection with their role in the mass action law for a partially ionized plasma. The two particle bound states are nearly density independent, while the continuum is essentially shifted. The single particle states are damped, and their energy has a negative shift and a parabolic behaviour for small momenta. (orig.)

Avalik kiri Riigikogule

Index Scriptorium Estoniae

2005-01-01

Ilmunud ka Postimees 2. märts lk. 2, Meie Maa 2. märts, lk. 2, Põhjarannik 2. märts, lk. 2, Severnoje Poberezhje 2. märts, lk. 2, Kesknädal 2. märts lk. 6, Maaleht, Pärnu Postimees 3. märts lk. 8,11, Hiiu Leht 11. märts lk. 2. 20. augustil 1991. aastal Eesti riikliku iseseisvuse taastamise poolt hääletanud pole rahul Eesti lipu seaduse eelnõu muudatusettepanekuga, mis lipu heiskamise muudab vabatahtlikuks taasiseseisvumispäeval 20. augustil

USA erisaadik : USA investorid Eestis rahul / J. Frank Mermoud ; interv. Sirje Rank

Index Scriptorium Estoniae

Mermoud, J. Frank

2004-01-01

Ameerika Ühendriikide välisministri nõunik ja erisaadik majandusküsimustes kiidab Eesti edu, räägib USA investorite rahuolust Eesti majanduskeskkonnaga ja väljendab muret Euroopa Liidu kavade pärast maksude ühtlustamiseks

Kaubamaja Naistemaailm = Tallinn Kaubamaja Ladies' World / Külli Salum, Riina Harik

Index Scriptorium Estoniae

Salum, Külli, 1971-

2013-01-01

Tallinna Kaubamaja Naistemaailma (Gonsiori 2) sisekujundusest. Autorid: Külli Salum ja Riina Harik (Saha IN). Skulptuurid: Kalle-Priit Pruuden. Sisearhitekti ja ESLi aastapreemiate žürii liikme Tarmo Piirmetsa arvamus

Kohvik Coffee Love = Café "Coffee Love"

Index Scriptorium Estoniae

2011-01-01

Tallinnas Kristiine keskuses asuva kohviku sisekujundusest. Sisearhitektid Ketsia Reismaa ja Külli Salum (Saha In OÜ). Loetletud sisearhitektide koos tehtud töid ja valik Külli Salumi tehtud töid

HDAC Inhibition Improves the Sarcoendoplasmic Reticulum Ca2+-ATPase Activity in Cardiac Myocytes.

Science.gov (United States)

Meraviglia, Viviana; Bocchi, Leonardo; Sacchetto, Roberta; Florio, Maria Cristina; Motta, Benedetta M; Corti, Corrado; Weichenberger, Christian X; Savi, Monia; D'Elia, Yuri; Rosato-Siri, Marcelo D; Suffredini, Silvia; Piubelli, Chiara; Pompilio, Giulio; Pramstaller, Peter P; Domingues, Francisco S; Stilli, Donatella; Rossini, Alessandra

2018-01-31

SERCA2a is the Ca 2+ ATPase playing the major contribution in cardiomyocyte (CM) calcium removal. Its activity can be regulated by both modulatory proteins and several post-translational modifications. The aim of the present work was to investigate whether the function of SERCA2 can be modulated by treating CMs with the histone deacetylase (HDAC) inhibitor suberanilohydroxamic acid (SAHA). The incubation with SAHA (2.5 µM, 90 min) of CMs isolated from rat adult hearts resulted in an increase of SERCA2 acetylation level and improved ATPase activity. This was associated with a significant improvement of calcium transient recovery time and cell contractility. Previous reports have identified K464 as an acetylation site in human SERCA2. Mutants were generated where K464 was substituted with glutamine (Q) or arginine (R), mimicking constitutive acetylation or deacetylation, respectively. The K464Q mutation ameliorated ATPase activity and calcium transient recovery time, thus indicating that constitutive K464 acetylation has a positive impact on human SERCA2a (hSERCA2a) function. In conclusion, SAHA induced deacetylation inhibition had a positive impact on CM calcium handling, that, at least in part, was due to improved SERCA2 activity. This observation can provide the basis for the development of novel pharmacological approaches to ameliorate SERCA2 efficiency.

Resonance – Journal of Science Education | News

Indian Academy of Sciences (India)

mediated Immunity · Asma Ahmed Banishree Saha Anand Patwardhan Shwetha Shivaprasad Dipankar Nandi · More Details Fulltext PDF. pp 622-629 Series Article. Snippets of Physics - Perturbing Coulomb to Avoid Accidents! T Padmanabhan.

Experimental study of static flow instability in subcooled flow boiling in parallel channels

International Nuclear Information System (INIS)

Siman-Tov, M.; Felde, D.K.; McDuffee, J.L.; Yoder, G.L.

1995-01-01

Experimental data for static flow instability or flow excursion (FE) at conditions applicable to the Advanced Neutron Source Reactor are very limited. A series of FE tests with light water flowing vertically upward was completed covering a local exit heat flux range of 0.7--18 MW/m 2 , exit velocity range of 2.8--28.4 m/s, exit pressure range of 0.117--1.7 MPa, and inlet temperature range of 40-- 50 degrees C. Most of the tests were performed in a ''stiff'' (constant flow) system where the instability threshold was detected through the minimum of the pressure-drop curve. A few tests were also conducted using as ''soft'' (constant pressure drop) a system as possible to secure a true FE phenomenon (actual secondary burnout). True critical heat flux experiments under similar conditions were also conducted using a stiff system. The FE data reported in this study considerably extend the velocity range of data presently available worldwide, most of which were obtained at velocities below 10 m/s. The Saha and Zuber correlation had the best fit with the data out of the three correlations compared. However, a modification was necessary to take into account the demonstrated dependence of the St and Nu numbers on subcooling levels, especially in the low subcooling regime. Comparison of Thermal Hydraulic Test Loop (THTL) data, as well as extensive data from other investigators, led to a proposed modification to the Saha and Zuber correlation for onset of significant void, applied to FE prediction. The mean and standard deviation of the THTL data were 0.95 and 15%, respectively, when comparing the THTL data with the original Saha and Zuber correlation, and 0.93 and 10% when comparing them with the modification. Comparison with the worldwide database showed a mean and standard deviation of 1.37 and 53%, respectively, for the original Saha and Zuber correlation and 1.0 and 27% for the modification

Atomic Emission Spectra Diagnosis and Electron Density Measurement of Semiconductor Bridge (SCB) Plasma

International Nuclear Information System (INIS)

Feng Hongyan; Zhu Shunguan; Zhang Lin; Wan Xiaoxia; Li Yan; Shen Ruiqi

2010-01-01

Emission spectra of a semiconductor bridge (SCB) plasma in a visible range was studied in air. The electron density was measured in a conventional way from the broadening of the A1 I 394.4 nm Stark width. Based on the Saha equation, a system for recording the intensity of Si I 390.5 nm and Si II 413.1 nm was designed. With this technique, the SCB plasma electron density was measured well and accurately. Moreover, the electron density distribution Vs time was acquired from one SCB discharge. The individual result from the broadening of the Al I 394.4 nm Stark width and Saha equation was all in the range of 10 15 cm -3 to 10 16 cm -3 . Finally the presumption of the local thermodynamic equilibrium (LTE) condition was validated.

Swamy et al., Afr J Tradit Complement Altern Med. (2014) 11(5):48 ...

African Journals Online (AJOL)

cadewumi

in rats supplemented with propolis prior to excitotoxic injury with kainic acid (KA). ... and necrotic cell death and induction of heat sensitive proteins in hippocampus and cortical regions of rodent brain (Akbar et al., ..... motor neurons in vitro.

Swamy et al., Afr J Tradit Complement Altern Med. (2014) 11(2):458 ...

African Journals Online (AJOL)

cadewumi

Materials and Methods: Male Sprague-Dawley rats were divided into four groups; ... induction of heat sensitive proteins in hippocampus and cortical regions of rodent ..... induce mitochondrial Ca2+overload and ROS generation in spinal motor.

Effects of three-body atomic interaction and optical lattice on solitons ...

Indian Academy of Sciences (India)

one-dimensional. Bose–Einstein condensate. Sk GOLAM ALI, B TALUKDAR∗ and APARNA SAHA. Department of Physics, Visva-Bharati University, Santiniketan 731 235, India. *Corresponding author. E-mail: binoy123@bsnl.in. MS received 23 ...

Fulltext PDF

Indian Academy of Sciences (India)

adhikari@saha.ac.in. Agrawal Pankaj, Institute of Physics,. Bhubaneswar, India agrawal@iopb.res.in. Agrawalla Sanjib K, Harish-Chandra. Research Institute, Allahabad, India sanjib@mri.ernet.in. Allanach Benjamin C, University of. Cambridge ...

PREFACE: Continuum Models and Discrete Systems Symposia (CMDS-12)

Science.gov (United States)

Chakrabarti, Bikas K.

2011-09-01

The 12th International Symposium on Continuum Models and Discrete Systems (CMDS-12) (http://www.saha.ac.in/cmp/cmds.12/) took place at the Saha Institute of Nuclear Physics in Kolkata from 21-25 February 2011. Previous CMDS symposia were held in Kielce (Poland, 1975), Mont Gabriel (Canada, 1977), Freudenstadt (Federal Republic of Germany, 1979), Stockholm (Sweden, 1981), Nottingham (United Kingdom, 1985), Dijon (France, 1989), Paderborn (Germany, 1992), Varna (Bulgaria, 1995), Istanbul (Turkey, 1998), Shoresh (Israel, 2003) and Paris (France, 2007). The broad interdisciplinary character, limited number of participants (not exceeding 100) and informal and friendly atmosphere of these meetings has made them a well-acknowledged place to make highly fruitful contacts and exchange ideas, methods and results. The purpose of CMDS is to bring together scientists with different backgrounds who work on continuum theories of discrete mechanical and thermodynamical systems in the fields of mathematics, theoretical and applied mechanics, physics, material science, and engineering. The spirit of the CMDS meetings is to stimulate extensive and active interdisciplinary research. The International Scientific Committee members of this conference were: David J Bergman (Chairman CMDS 10), Tel Aviv University, Israel; Bikas K Chakrabarti (Chairman CMDS 12), Saha Institute of Nuclear Physics, India; Alex Hansen, Norwegian University of Science and Technology, Norway; Hans Jürgen Herrmann, Institute for Building Materials, ETH, Switzerland; Esin Inan (Chairman CMDS 9), Istanbul Technical University, Turkey; Dominique Jeulin (Chairman CMDS 11), Ecole des Mines de Paris, France; Frank Juelicher, Max-Planck-Institute for the Physics of Complex Systems, Germany; Hikaru Kawamura, University of Osaka, Japan; Graeme Milton, University of Utah, USA; Natalia Movchan, University of Liverpool, UK; and Ping Sheng, The Hong Kong University of Science and Technology, Hong Kong. At CMDS-12 the topics

Construction of classical and quantum integrable field models ...

Indian Academy of Sciences (India)

Theory Division, Saha Institute of Nuclear Physics, Kolkata 700 064, India .... above models takes only two different forms: rational or trigonometric ..... parameters c, α, μ, which for different continuum choices for these parameters allows to. 910.

original article

African Journals Online (AJOL)

2009-10-01

Oct 1, 2009 ... tests of attention and concentration, movement and co- ordination ... Africa, but it was insensitive to memory impairment in asymptomatic HIV-positive patients. 38 ... ments may be affected by different clades in sub-Saha-.

A Conversation on Standard 90.1-2016

Energy Technology Data Exchange (ETDEWEB)

Erbe, Drake; Lord, Richard; Sciarra, Leonard [Len; Richman, Eric E.; Rosenberg, Michael I.; Athalye, Rahul A.; Liu, Bing; Glazer, Jason

2016-12-08

The roundtable discussion: A Conversation on Standard 90.1-2016, highlights some of the major changes one can expect to see in building envelope, mechanical system, and lighting requirements. In addition, the article highlights a new performance-based compliance path, climate zone revisions, and the strategic initiatives resulting in the new format. This roundtable was conducted by ASHRAE Journal with Drake Erbe, Member ASHRAE; Dick Lord, Fellow ASHRAE; Len Sciarra, AIA, Member ASHRAE; Eric Richman, Member ASHRAE; Michael Rosenberg, Member ASHRAE; Rahul Athalye, Associate Member ASHRAE; Bing Liu, P.E., Member ASHRAE; and Jason Glazer, P.E., Member ASHRAE.

In this section of Resonance, we invite readers to pose questions ...

Indian Academy of Sciences (India)

Author Affiliations. Kaushik Basu1 Suchandra Chakraborty2 Chandan Saha2. Department of Chemistry St Paul's Cathedral Mission College Kolkata 700 009, India. Department of Clinical and Experimental Pharmacology School of Tropical Medicine Kolkata 700 073, India.

Resonance – Journal of Science Education | Indian Academy of ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 17; Issue 8. Dissymmetry and Asymmetry - A Hopeless Conflict in Chemical Literature. Chandan Saha Suchandra Chakraborty. General Article Volume 17 Issue 8 August 2012 pp 768-778 ...

On some three-dimensional problems of piezoelectricity | Saha ...

African Journals Online (AJOL)

The problem of an elliptical crack embedded in an unbounded transversely isotropic piezoelectric medium and subjected to remote normal loading is considered first. The integral equation method developed by Roy and his coworkers has been applied suitably with proper modifications to solve the problem. The method ...

Bulletin of Materials Science

Indian Academy of Sciences (India)

-organic chemical vapour deposited (MOCVD) gamma iron oxide thin film for ... V2)5-Te)2 glasses using heterogeneous conductor model -- M Pal, S K Saha and ... The hardness-flow stress correlation in metallic materials -- G Soundararajan ...

Fluid phases of hydrogen-bound states and thermodynamical properties

International Nuclear Information System (INIS)

Ebeling, W.; Kraeft, W.D.

1985-08-01

The fluid phases of hydrogen and especially the existence of two critical points, the density dependence of the two - particle states and the effective interactions are discussed. An effective Schroedinger equation and a Saha equation are given. (author)

Endoscopic versus external approach dacryocystorhinostomy: A ...

African Journals Online (AJOL)

Endoscopic versus external approach dacryocystorhinostomy: A comparative analysis. Rinki Saha, Anuradha Sinha, Jyoti Prakash Phukan. Abstract. Background: Dacryocystorhinostomy (DCR) consists of creating a lacrimal drainage pathway to the nasal cavity to restore permanent drainage of previously obstructed ...

Fulltext PDF

Indian Academy of Sciences (India)

overwhelming as to make the practice of science incomparably more difficult ... Romi Bhabha and, say, Megh N ad Saha on what needed to be. "Most of ... "Art, music, poetry ... quantum mechanics, and elementary particle physics at that time.

Computed Tomographic Morphometry of the Internal Anatomy of Mandibular Second Primary Molars.

Science.gov (United States)

Kurthukoti, Ameet J; Sharma, Pranjal; Swamy, Dinesh Francis; Shashidara, R; Swamy, Elaine Barretto

2015-01-01

Need for the study: The most important procedure for a successful endodontic treatment is the cleaning and shaping of the canal system. Understanding the internal anatomy of teeth provides valuable information to the clinician that would help him achieve higher clinical success during endodontic therapy. To evaluate by computed tomography-the internal anatomy of mandibular second primary molars with respect to the number of canals, cross-sectional shape of canals, cross-sectional area of canals and the root dentin thickness. A total of 31 mandibular second primary molars were subjected to computed-tomographic evaluation in the transverse plane, after mounting them in a prefabricated template. The images, thus, obtained were analyzed using De-winter Bio-wizard® software. All the samples demonstrated two canals in the mesial root, while majority of the samples (65.48%) demonstrated two canals in the distal root. The cross-sectional images of the mesial canals demonstrated a round shape, while the distal canals demonstrated an irregular shape. The root dentin thickness was highly reduced on the distal aspect of mesial and mesial aspect of distal canals. The mandibular second primary molars demonstrated wide variation and complexities in their internal anatomy. A thorough understanding of the complexity of the root canal system is essential for understanding the principles and problems of shaping and cleaning, determining the apical limits and dimensions of canal preparations, and for performing successful endodontic procedures. How to cite this article: Kurthukoti AJ, Sharma P, Swamy DF, Shashidara R, Swamy EB. Computed Tomographic Morphometry of the Internal Anatomy of Mandibular Second Primary Molars. Int J Clin Pediatr Dent 2015;8(3):202-207.

Enhanced collaboration between CERN and India

CERN Multimedia

2009-01-01

On Monday 22 June, Bikash Sinha, Director of the SAHA Institute of Nuclear Physics (SINP) and the Variable Energy Cyclotron Centre (VECC) in Kolkata, India and Rolf Heuer, CERN Director-General, signed new protocols to the long standing agreement between the Indian Atomic Energy Commission and CERN. This provides a framework for collaboration in low energy nuclear physics between SAHA and VECC and the ISOLDE experiment at CERN. SINP and VECC Director Bikash Sinha and CERN Director-General Rolf Heuer signing the ISOLDE Protocols. SINP and VECC Director Bikash Sinha and CERN Research Director Sergio Bertolucci with representatives of the ISOLDE and RD51 Collaborations.INDIA has a long standing tradition in basic nuclear physics and nuclear chemistry. SINP is a leading institute for basic research and training in physical and biophysical sciences with particular competence in nuclear spectroscopy a...

Multifilmionu on tehtuga rahul / Priit Pärn ; interv. Rünno Saaremäe

Index Scriptorium Estoniae

Pärn, Priit, 1946-

2001-01-01

Priit Pärn eesti animafilmi olukorrast, oma tööst, 2. nov. Rakvere Keslinna galeriis avatud isikunäitusest "Pärna maailm" (30. novembrini näidatakse Rakveres Virma Dragon House'is iga päev kell 16 tema animafilme). Ottawa filmifestivalil anti Priit Pärnale ASIFA Special Award elutöö eest

Fulltext PDF

Indian Academy of Sciences (India)

ufrj.br. Majumdar Shaoli, UGC-DAE Consortium for Scientific Research, Kolkata Centre,. 3/LB-8, Bidhan Nagar, Kolkata 700 098, India shaoli.81@gmail.com. Majumder Harasit, Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar,. Kolkata 700 ...

Fulltext PDF

Indian Academy of Sciences (India)

Admin

748 C- Past, Present, and Future - A Perspective. KBhaskar. 759. Plant Tissue Culture. Historical Developments and Applied Aspects. HR Dagla. 768. Dissymmetry and Asymmetry. A Hopeless Conflict in Chemical Literature. Chandan Saha and Suchandra Chakraborty. 768. RESEARCH NEWS. 791. Substrate Channelling.

to view fulltext PDF

Indian Academy of Sciences (India)

THE ORIGIN OF MASS IN NEUTRONS AND PROTONS.·. By M. N. SAHA ... of GalUeo--Newtonian mechanics, but discoveries in physics within the last sixty years have .... Before 1932, the other fundamental particle was the proton. The task of ...

A new spectrofluorimetric assay method for vandetanib in tablets ...

African Journals Online (AJOL)

556. 7. Balwani G, Joseph E, Reddi S, Nagpal V, Saha RN. Rapid, Simple, and Sensitive Spectrofluorimetric Method for the Estimation of Ganciclovir in Bulk and. Pharmaceutical Formulations. J Spectrosc 2013;. 2013:1-5. 8. Bai F, Johnson J, ...

In this section of Resonance, we invite readers to pose questions ...

Indian Academy of Sciences (India)

2016-08-26

Aug 26, 2016 ... Author Affiliations. Kaushik Basu1 Suchandra Chakraborty2 Chandan Saha2. Department of Chemistry St Paul's Cathedral Mission College Kolkata 700 009, India. Department of Clinical and Experimental Pharmacology School of Tropical Medicine Kolkata 700 073, India.

Near-horizon states of black holes and Calogero models -2

Indian Academy of Sciences (India)

Theory Division, Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, ... We find self-adjoint extensions of the rational Calogero model in the presence .... positive integer, corresponding to the choice of z = z1 = π + 2η1. similarly, when.

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Recognition of self-assembled water-nitrate cluster in a Co(III)-2,2'-bipyridine host: Synthesis, X-ray structure, DNA cleavage, molecular docking and anticancer activity · SUBRATA DAS ANANDAN RANJANI LOGANATHAN GAYATHRI SUBHASISH SAHA JORGE PASAN DHARUMADURAI DHANASEKARAN MOHAMMAD ...

Fulltext PDF

Indian Academy of Sciences (India)

Admin

455 The Major Players in Adaptive Immunity. Humoral Immunity. Asama Ahmed, Banishree Saha, Anand Patwardhan,. Shwetha Shivaprasad and Dipankar Nandi. 472 The Saga of the HIV Controversy. Nobel Prize in Physiology or Medicine – 2008. Udaykumar Ranga. 430. 416. 508 ...

Fulltext PDF

Indian Academy of Sciences (India)

WHEPP-8 received partial financial support from Indian Institute of Technology,. Mumbai, Tata Institute of Fundamental Research, Mumbai, Harish-Chandra Re- search Institute, Allahabad, Saha Institute of Nuclear Physics, Kolkata, Institute of Physics, Bhubaneswar, Institute of Mathematical Sciences, Chennai. We thank.

Evaluation of 6-([{sup 18}F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain

Energy Technology Data Exchange (ETDEWEB)

Reid, Alicia E. [National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 (United States); Medical Department, Brookhaven National Laboratory, Upton, NY 11973 (United States)], E-mail: areid@bnl.gov; Hooker, Jacob; Shumay, Elena; Logan, Jean; Shea, Colleen; Kim, Sung Won [Medical Department, Brookhaven National Laboratory, Upton, NY 11973 (United States); Collins, Shanika [School of Science, Health and Technology Medgar Evers College, Brooklyn, NY 11225 (United States); Xu Youwen [Medical Department, Brookhaven National Laboratory, Upton, NY 11973 (United States); Volkow, Nora [National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 (United States); National Institute on Drug Abuse, Bethesda, MD 20892 (United States); Fowler, Joanna S. [Medical Department, Brookhaven National Laboratory, Upton, NY 11973 (United States)

2009-04-15

Introduction: Histone deacetylases (HDACs) are enzymes involved in epigenetic modifications that shift the balance toward chromatin condensation and silencing of gene expression. Here, we evaluate the utility of 6-([{sup 18}F]fluoroacetamido)-1-hexanoicanilide ([{sup 18}F]FAHA) for positron emission tomography imaging of HDAC activity in the baboon brain. For this purpose, we assessed its in vivo biodistribution, sensitivity to HDAC inhibition, metabolic stability and the distribution of the putative metabolite [{sup 18}F]fluoroacetate ([{sup 18}F]FAC). Methods: [{sup 18}F]FAHA and its metabolite [{sup 18}F]FAC were prepared, and their in vivo biodistribution and pharmacokinetics were determined in baboons. [{sup 18}F]FAHA metabolism and its sensitivity to HDAC inhibition using suberanilohydroxamic acid (SAHA) were assessed in arterial plasma and by in vitro incubation studies. The chemical form of F-18 in rodent brain was assessed by ex vivo studies. Distribution volumes for [{sup 18}F]FAHA in the brain were derived. Results: [{sup 18}F]FAHA was rapidly metabolized to [{sup 18}F]FAC, and both labeled compounds entered the brain. [{sup 18}F]FAHA exhibited regional differences in brain uptake and kinetics. In contrast, [{sup 18}F]FAC showed little variation in regional brain uptake and kinetics. A kinetic analysis that takes into account the uptake of peripherally produced [{sup 18}F]FAC indicated that SAHA inhibited binding of [{sup 18}F]FAHA in the baboon brain dose-dependently. In vitro studies demonstrated SAHA-sensitive metabolism of [{sup 18}F]FAHA to [{sup 18}F]FAC within the cell and diffusion of [{sup 18}F]FAC out of the cell. All radioactivity in brain homogenate from rodents was [{sup 18}F]FAC at 7 min postinjection of [{sup 18}F]FAHA. Conclusion: The rapid metabolism of [{sup 18}F]FAHA to [{sup 18}F]FAC in the periphery complicates the quantitative analysis of HDAC in the brain. However, dose-dependent blocking studies with SAHA and kinetic modeling

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

Narendra Gajbhiye1 V Eswaran2 A K Saha1 Anoop Kumar3. Department of Mechanical Engineering, IIT Kanpur, Kanpur 208016, India; Department of Mechanical and Aerospace Engineering, IIT Hyderabad, Hyderabad 502205, India; Department of Mechanical Engineering, NIT Hamirpur, Hamirpur 177005, India ...

Resonance – Journal of Science Education | Indian Academy of ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 5. The Major Players in Adaptive Immunity - Humoral Immunity. Asma Ahmed Banishree Saha Anand Patwardhan Shwetha Shivprasad Dipankar Nandi. General Article Volume 14 Issue 5 May 2009 pp 455-471 ...

The Major Players in Adaptive Immunity-Cell-mediated Immunity

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 6. The Major Players in Adaptive Immunity - Cell-mediated Immunity. Asma Ahmed Banishree Saha Anand Patwardhan Shwetha Shivaprasad Dipankar Nandi. General Article Volume 14 Issue 6 June 2009 pp 610-621 ...

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Earth System Science; Volume 126; Issue 4. Deep learning for predicting the monsoon over the homogeneous regions of India. Moumita Saha Pabitra Mitra ... Keywords. Feature learning; stacked autoencoder; monsoon predictor; ensemble of regression trees; regional Indian summer monsoon.

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Author Affiliations. G Mariappan1 B P Saha1 Sriparna Datta1 Deepak Kumar1 P K Haldar2. Department of Medicinal Chemistry, Himalayan Pharmacy Institute, East Sikkim 737 136, India; Department of Pharmacology, Himalayan Pharmacy Institute, East Sikkim 737 136, India ...

Classroom

Indian Academy of Sciences (India)

sharing personal experiences and viewpoints on matters related to teaching and learning science. Abhishek Saha. B. Math. Hons. 1st year ... Proof. Let Pb P2,. ,Ps be the various distinct prime divisors of p - 1. Thus. E=.!. k p-1 s. Pj.

Fulltext PDF

Indian Academy of Sciences (India)

Chandra Research Institute, Allahabad; Institute of Mathematical Sciences,. Chennai; International Union of Pure and Applied Physics; Saha Institute of. Nuclear Physics, Kolkata and Tata Institute of Fundamental Research, Mumbai for their generous financial support. Rohini Godbole. Indian Institute of Science, Bangalore ...

SARIYER, BEYKOZ VE ŞİLE’DE (İSTANBUL) COĞRAFYA EĞİTİMİ İÇİN ROTA ÖNERİLERİ

OpenAIRE

Tuna, Fikret; Sarıkaya, Mehmet Akif

2014-01-01

Konusu yani inceleme alanı gereği doğal çevrenin yerinde incelenmesine, gözleme ve uygulamaya dayalı bir bilim olan coğrafyada, öğretilen pek çok konunun sınıfın dışına çıkılarak yerinde gözlenmesi ve incelenmesi büyük önem taşımaktadır. Bu nedenle, coğrafya denilince ilk akla gelenlerden birisi yerinde gözlem ve inceleme yani saha çalışmalarıdır. Ayrıca, saha çalışmaları, coğrafya eğitimine çok çeşitli katkılar sağlamaktadır. Bu çalışmanın temel amacı, coğrafya eğitimcilerine derslerinde fay...

The calculation of electron chemical potential and ion charge state and their influence on plasma conductivity in electrical explosion of metal wire

International Nuclear Information System (INIS)

Shi, Zongqian; Wang, Kun; Li, Yao; Shi, Yuanjie; Wu, Jian; Jia, Shenli

2014-01-01

The electron chemical potential and ion charge state (average ion charge and ion distribution) are important parameters in calculating plasma conductivity in electrical explosion of metal wire. In this paper, the calculating method of electron chemical potential and ion charge state is discussed at first. For the calculation of electron chemical potential, the ideal free electron gas model and Thomas-Fermi model are compared and analyzed in terms of the coupling constant of plasma. The Thomas-Fermi ionization model, which is used to calculate ion charge state, is compared with the method based on Saha equation. Furthermore, the influence of electron degenerated energy levels and ion excited states in Saha equation on the ion charge state is also analyzed. Then the influence of different calculating methods of electron chemical potential and ion charge state on plasma conductivity is discussed by applying them in the Lee-More conductivity model

Studies Using an in Vitro Model Show Evidence of Involvement of Epithelial-Mesenchymal Transition of Human Endometrial Epithelial Cells in Human Embryo Implantation*

Science.gov (United States)

Uchida, Hiroshi; Maruyama, Tetsuo; Nishikawa-Uchida, Sayaka; Oda, Hideyuki; Miyazaki, Kaoru; Yamasaki, Akiko; Yoshimura, Yasunori

2012-01-01

Human embryo implantation is a critical multistep process consisting of embryo apposition/adhesion, followed by penetration and invasion. Through embryo penetration, the endometrial epithelial cell barrier is disrupted and remodeled by an unknown mechanism. We have previously developed an in vitro model for human embryo implantation employing the human choriocarcinoma cell line JAR and the human endometrial adenocarcinoma cell line Ishikawa. Using this model we have shown that stimulation with ovarian steroid hormones (17β-estradiol and progesterone, E2P4) and suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, enhances the attachment and adhesion of JAR spheroids to Ishikawa. In the present study we showed that the attachment and adhesion of JAR spheroids and treatment with E2P4 or SAHA individually induce the epithelial-mesenchymal transition (EMT) in Ishikawa cells. This was evident by up-regulation of N-cadherin and vimentin, a mesenchymal cell marker, and concomitant down-regulation of E-cadherin in Ishikawa cells. Stimulation with E2P4 or SAHA accelerated Ishikawa cell motility, increased JAR spheroid outgrowth, and enhanced the unique redistribution of N-cadherin, which was most prominent in proximity to the adhered spheroids. Moreover, an N-cadherin functional blocking antibody attenuated all events but not JAR spheroid adhesion. These results collectively provide evidence suggesting that E2P4- and implanting embryo-induced EMT of endometrial epithelial cells may play a pivotal role in the subsequent processes of human embryo implantation with functional control of N-cadherin. PMID:22174415

Reactivation of latent HIV-1 by new semi-synthetic ingenol esters

Energy Technology Data Exchange (ETDEWEB)

Pandeló José, Diego [Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902 (Brazil); Bartholomeeusen, Koen [Department of Medicine, Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143-0703 (United States); Delveccio da Cunha, Rodrigo; Abreu, Celina Monteiro [Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902 (Brazil); Glinski, Jan [PlantaAnalytica LLC, Danbury, CT 06810 (United States); Barbizan Ferreira da Costa, Thais; Bacchi Rabay, Ana Flávia Mello; Pianowski Filho, Luiz Francisco [Kyolab Laboratories, Valinhos, São Paulo 13273-105 (Brazil); Dudycz, Lech W. [Lex Company Research Laboratories, Shirley 01464, MA (United States); Ranga, Udaykumar [Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru 560064 (India); Peterlin, Boris Matija [Department of Medicine, Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143-0703 (United States); Pianowski, Luiz Francisco [Kyolab Laboratories, Valinhos, São Paulo 13273-105 (Brazil); Tanuri, Amilcar [Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902 (Brazil); Aguiar, Renato Santana, E-mail: santana@biologia.ufrj.br [Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902 (Brazil)

2014-08-15

The ability of HIV to establish long-lived latent infection is mainly due to transcriptional silencing of viral genome in resting memory T lymphocytes. Here, we show that new semi-synthetic ingenol esters reactivate latent HIV reservoirs. Amongst the tested compounds, 3-caproyl-ingenol (ING B) was more potent in reactivating latent HIV than known activators such as SAHA, ingenol 3,20-dibenzoate, TNF-α, PMA and HMBA. ING B activated PKC isoforms followed by NF-κB nuclear translocation. As virus reactivation is dependent on intact NF-κB binding sites in the LTR promoter region ING B, we have shown that. ING B was able to reactivate virus transcription in primary HIV-infected resting cells up to 12 fold and up to 25 fold in combination with SAHA. Additionally, ING B promoted up-regulation of P-TEFb subunits CDK9/Cyclin T1. The role of ING B on promoting both transcription initiation and elongation makes this compound a strong candidate for an anti-HIV latency drug combined with suppressive HAART. - Highlights: • 3-caproyl-ingenol (ING B) reactivates latent HIV better than SAHA, ingenol 3,20-dibenzoate, TNF-α, PMA and HMBA. • ING B promotes PKC activation and NF-kB translocation to the nucleus. • ING B activates virus transcription of B and non-B subtypes of HIV-1. • ING B activates HIV transcription in infected primary resting CD4+ T cells. • ING B induces higher levels of P-TEFb components in human primary cells.

Potential anti-cancer activity of N-hydroxy-7-(2-naphthylthio) heptanomide (HNHA), a histone deacetylase inhibitor, against breast cancer both in vitro and in vivo

International Nuclear Information System (INIS)

Park, Ki-Cheong; Kim, Seung-Won; Park, Ji-Hyun

2011-01-01

Histone deacetylase (HDAC) is an attractive target for cancer therapy because it plays a key role in gene expression and carcinogenesis. N-hydroxy-7-(2-naphthylthio) heptanomide (HNHA) is a novel synthetic HDAC inhibitor (HDACI) that shows better pharmacological properties than a known HDACI present in the human fibrosarcoma cell: suberoylanilide hydroxamic acid (SAHA). Here, we investigate the anti-cancer activity of HNHA against breast cancer both in vitro and in vivo. HNHA arrested the cell cycle at the G 1 /S phase via p21 induction, which led to profound inhibition of cancer cell growth in vitro. In addition, HNHA-treated cells showed markedly decreased levels of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF)-1α than SAHA and fumagillin (FUMA) when accompanied by increased histone acetylation. HNHA significantly inhibited tumor growth in an in vivo mouse xenograft model. HNHA-treated mice survived significantly longer than SAHA- and FUMA-treated mice. Dynamic MRI showed significantly decreased blood flow in the HNHA-treated mice, implying that HNHA inhibits tumor neovascularization. This finding was accompanied by marked reductions of proangiogenic factors and significant induction of angiogenesis inhibitors in tumor tissues. We have shown that HNHA is an effective anti-tumor agent in breast cancer cells in vitro and in breast cancer xenografts in vivo. Collectively, these findings indicate that HNHA may be a potent anti-cancer agent against breast cancer due to its multi-faceted inhibition of HDAC activity, as well as anti-angiogenesis activity. (author)

A review of the discovery of SM-like Higgs boson in H→ γγ decay ...

Indian Academy of Sciences (India)

Home; Journals; Pramana – Journal of Physics; Volume 87; Issue 3. A review ... Saha Institute of Nuclear Physics, 1/AF, Bidhan Nagar, Kolkata 700 064, India; National Central University, No. 300 ... Proceedings of the International Workshop/Conference on Computational Condensed Matter Physics and Materials Science

Membrane Reflector Vertical Cavity Lasers at Near- and Midwave-Infrared

Science.gov (United States)

2014-05-30

independent broadband reflectors based on cross-stacked gratings, Optics Express, (04 2011): 9050. doi: 10.1364/OE.19.009050 Tapas Kumar Saha, Mingyu Lu... Mingyu Lu, Huiqing Zhai, Deyin Zhao, Weidong Zhou. Design of a compact grating coupler with controllable linewidths via transverse resonance and

Suchandra Chakraborty

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Suchandra Chakraborty. Articles written in Resonance – Journal of Science Education. Volume 17 Issue 8 August 2012 pp 768-778 General Article. Dissymmetry and Asymmetry - A Hopeless Conflict in Chemical Literature · Chandan Saha Suchandra ...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences; Volume 119; Issue 2. Comparative photophysical behaviour of naphthalene-linked crown ethers and aza crown ethers of varying cavity dimensions. Subhodip Samanta Pinki Saha Sardar Shyam Sundar Maity Anirban Pal Maitrayee Basu Roy Sanjib Ghosh. Volume 119 Issue ...

New Fellows and Honorary Fellow

Indian Academy of Sciences (India)

Saha, Prof. Ajit Kumar Ph.D. (Calcutta and Toronto), FNA. Date of birth: 25 May 1925. Date of death: 27 April 1997. Specialization: Petrology, Geochemistry, Precambrian Geology and Environmental Geology Last known address: Emeritus Professor of Geology, Department of Geology, Presidency College, Calcutta 700 073.

Scientific Staff | ast.noao.edu

Science.gov (United States)

support (GMOS), Gemini archive support, NOAO LSST science working group, SCD/ANTARES Tucson Joan Najita ; quasars NOAO Diversity Co-Advocate, Gemini user support (GMOS) (also assigned NDO, see above) Tucson Knut Associate Scientist Quasar host galaxies Gemini user support (NIRI, GMOS) Tucson Abhijit Saha (Abi

Enhancement of Radiation Therapy in Prostate Cancer by DNA-PKcs Inhibitor

Science.gov (United States)

2015-09-01

Center, Urology Habib , Amyn; UTSouthwestern Medical Center, Neurology & Neurotherapeutics Chen, Benjamin; UTSouthwestern Medical Center, Radiation...Tsong Hsieh 3,5,7 , Amyn A. Habib 4,5,6 , Benjamin Chen 1,4 and Debabrata Saha 1,4 1 Department of Radiation Oncology, 3 Department of Urology, 4

Mineral phosphate solubilizing bacterial community in agro-ecosystem

African Journals Online (AJOL)

Mineral phosphate solubilizing bacterial community in agro-ecosystem. N Saha, S Biswas. Abstract. The present communication deals with the assessment of phosphate solubilizing bacterial community structure across artificially created fertility gradient with regards to N, P and K status of soil in the experimental site.

An analytical excitation model for an ionizing plasma

NARCIS (Netherlands)

Mullen, van der J.J.A.M.; Sijde, van der B.; Schram, D.C.

1983-01-01

From an analytical model for the population of high-lying excited levels in ionizing plasmas it appears that the distribution is a superposition of the equilibrium (Saha) value and an overpopulation. This overpopulation takes the form of a Maxwell distribution for free electrons. Experiments for He

Fulltext PDF

Indian Academy of Sciences (India)

mathematical, and social sciences. ... The themes explored at the Berlin meeting ranged from studies of complex networks to extreme events in ... Saha and coworkers have used recurrence plots to characterize natural circulation loops that are of importance in passive thermal management devices, while Tadic, Andjelkovic ...

An analytical excitation for an ionizing plasma

NARCIS (Netherlands)

Mullen, van der J.J.A.M.; Sijde, van der B.; Schram, D.C.

1983-01-01

From an analytical model for the population of high-lying excited levels in ionizing plasmas it appears that the distribution is a superposition of the equilibrium (Saha) value and an overpopulation. This overpopulation takes the form of a Maxwell distribution for free electrons. Experiments for He

Involution symmetries and the PMNS matrix

Indian Academy of Sciences (India)

Palash B Pal

2017-10-09

Oct 9, 2017 ... 1Saha Institute of Nuclear Physics, Block-AF, Sector-1, Bidhan Nagar, Kolkata 700 064, India ... paper [3] we take the third assumption in addition, and try to find symmetries ..... a finite subgroup of it that can fit the bill. We make ...

Fulltext PDF

Indian Academy of Sciences (India)

Bhabha And His Magnificent. Obsessions. G Venkataraman. Universities Press India Ltd. Orient Longman Ltd. 1994, Rs.85. The Many Phases Of Matter. G Venkataraman. Universities Press India Ltd. Orient Longman Ltd. 1991, Rs.60. Saha And His Formula. G Venkataraman. Universities Press India Ltd. Orient Longman ...

Resonance – Journal of Science Education | Indian Academy of ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Dipankar Nandi. Articles written in Resonance – Journal of Science Education. Volume 14 Issue 5 May 2009 pp 455-471 General Article. The Major Players in Adaptive Immunity - Humoral Immunity · Asma Ahmed Banishree Saha Anand Patwardhan Shwetha ...

Asma Ahmed

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Asma Ahmed. Articles written in Resonance – Journal of Science Education. Volume 14 Issue 5 May 2009 pp 455-471 General Article. The Major Players in Adaptive Immunity - Humoral Immunity · Asma Ahmed Banishree Saha Anand Patwardhan Shwetha ...

Shwetha Shivaprasad

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Shwetha Shivaprasad. Articles written in Resonance – Journal of Science Education. Volume 14 Issue 6 June 2009 pp 610-621 General Article. The Major Players in Adaptive Immunity - Cell-mediated Immunity · Asma Ahmed Banishree Saha Anand Patwardhan ...

Shwetha Shivprasad

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Shwetha Shivprasad. Articles written in Resonance – Journal of Science Education. Volume 14 Issue 5 May 2009 pp 455-471 General Article. The Major Players in Adaptive Immunity - Humoral Immunity · Asma Ahmed Banishree Saha Anand Patwardhan ...

Resonance – Journal of Science Education | News

Indian Academy of Sciences (India)

pp 768-778 General Article. Dissymmetry and Asymmetry - A Hopeless Conflict in Chemical Literature · Chandan Saha Suchandra Chakraborty · More Details Fulltext PDF. pp 779-790 Classroom. Analysing Spherical Aberration in Concave Mirrors · Ranjit Konkar · More Details Fulltext PDF. pp 791-796 Research News.

Emergency separation of a xipho-omphalopagus twin in a ...

African Journals Online (AJOL)

Emergency separation of a xipho-omphalopagus twin in a developing country. RM Shukla, B Mukhopadhyay, KC Mandal, K Saha, D Roy, PP Mukherjee. Abstract. Female conjoined twins (thoraco-omphalopagus) were delivered by emergency caesarean section in a private nursing home. On examination, one of the twins ...

Tushar Jana

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. Tushar Jana. Articles written in Bulletin of Materials Science. Volume 32 Issue 5 October 2009 pp 507-514 Polymers. Functionalization of hydroxyl terminated polybutadiene with biologically active fluorescent molecule · R Murali Sankar Subhadeep Saha K Seeni Meera Tushar ...

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

APARNA SAHA1 B TALUKDAR1 UMAPADA DAS2 SUPRIYA CHATTERJEE3. Department of Physics, Visva Bharati University, Santiniketan 731 235, India; Department of Physics, Abhedananda College, Sainthia 731 234, India; Department of Physics, Bidhannagar College, EB-2, Sector-1, Salt Lake, Kolkata 700 064, ...

Occurrence of the Madras Tree Shrew Anathana ellioti (Waterhouse (Scandentia: Tupaiidae in the Biligirirangan Hills, Karnataka, India

Directory of Open Access Journals (Sweden)

U. Srinivasan

2009-05-01

Full Text Available The Madras Tree Shrew Anathana ellioti (Waterhouse 1850 is a small mammal belonging to the order Scandentia, and is endemic to peninsular India. It inhabits deciduous forests and has till date not been reported from the Biligiriranga Swamy Temple Wildlife Sanctuary (BRT WLS or the contiguous hill ranges or from anywhere else in the state of Karnataka. We provide details of nine independent sightings of this species from six locations in the BRT WLS between 2003 and 2008. Photographs of the three individuals from different locations are also presented. These records indicate an extension of the range of this species in the BRT WLS, and possibly the forests contiguous to the protected area.

Utilization of Boron Compounds for the Modification of Suberoyl Anilide Hydroxamic Acid as Inhibitor of Histone Deacetylase Class II Homo sapiens

Science.gov (United States)

Bakri, Ridla; Parikesit, Arli Aditya; Satriyanto, Cipta Prio; Kerami, Djati; Tambunan, Usman Sumo Friend

2014-01-01

Histone deacetylase (HDAC) has a critical function in regulating gene expression. The inhibition of HDAC has developed as an interesting anticancer research area that targets biological processes such as cell cycle, apoptosis, and cell differentiation. In this study, an HDAC inhibitor that is available commercially, suberoyl anilide hydroxamic acid (SAHA), has been modified to improve its efficacy and reduce the side effects of the compound. Hydrophobic cap and zinc-binding group of these compounds were substituted with boron-based compounds, whereas the linker region was substituted with p-aminobenzoic acid. The molecular docking analysis resulted in 8 ligands with ΔG binding value more negative than the standards, SAHA and trichostatin A (TSA). That ligands were analyzed based on the nature of QSAR, pharmacological properties, and ADME-Tox. It is conducted to obtain a potent inhibitor of HDAC class II Homo sapiens. The screening process result gave one best ligand, Nova2 (513246-99-6), which was then further studied by molecular dynamics simulations. PMID:25214833

Alternative approach to the surface-excitation model

International Nuclear Information System (INIS)

Krohn, V.E.

1981-01-01

Although the development of the surface-excitation model of sputtered-ion emission involved a detailed description of the ionization process, one can arrive at the same result by assuming an equilibrium treatment, e.g. the Saha-Langmuir equation, with the temperature falling as the collision casade develops. This suggests that, even if situations are found where the surface-excitation model is successful, it does not follow that the original detailed description of the ionization process is correct. Nevertheless, the surface-excitation model does contain an interesting new idea which should not be overlooked, i.e. that atoms sputtered during the early stages of a collision cascade will be relatively energetic, and to the extent that the Saha-Langmuir equation has some applicability, will have a probability of positive ionization which will be low for atoms of low ionization potential (I phi), relative to lower-energy atoms emitted during the later stages of the collision cascade. The extended abstract will discuss recent experimental results

EREĞLİ (KONYA) İLÇESİNDE MEYVECİLİK

OpenAIRE

TAPUR, TAHSİN; BOZYİĞİT, RECEP

2013-01-01

ÖZETAraştırma Sahası, İç Anadolu Bölgesi’nin güneydoğusunda yer alır. Ereğli ilçesidir. Bu çalışmanın amacı, Ereğli’de meyveciliğin dağılımını, üretimini ve gelişimini ortaya koymaktır. Araştırmanın ilk aşamasında konu ile ilgili literatür incelenmiştir. Daha sonra çeşitli tarihlerde (Eylül 2008 veTemmuz 2009) arazi incelemeleri yapılmıştır. Saha çalışması ile elde edilen bilgiler, literatür ve SWOT/GZFT analiz yöntemi ile değerlendirilmiştir.Çalışma alanında meyveciliğin gelişmesi üzerinde f...

İMAGOLOJİ / IMAGOLOGY

Directory of Open Access Journals (Sweden)

Ertan ENGİN

2012-07-01

Full Text Available Karşılaştırmalı edebiyat çalışmaları içinde bir alt disiplin, yan dal olarak ortaya çıkan ve zaman geçtikçe araştırmacılar tarafından daha çok ilgi gören imagoloji, toplumların birbirlerini nasıl gördüklerini inceleyen ve bunu da çoğunlukla/öncelikle kendisi için en elverişli malzemeyi sağlayacak edebiyat eserleri üzerinden gerçekleştiren bir araştırma sahasıdır. Bu yazıda söz konusu araştırma sahasının kökeninde yer alan ‘imaj’ kavramı ile birlikte, imagolojinin kapsam ve metodolojisinde dikkatimizi çeken bazı noktalara değinilmiştir.

Kanishka Biswas

Indian Academy of Sciences (India)

Kanishka Biswas

(Solid state inorganic chemistry). (Metal chalcogenide chemistry). Manoj K. Jana. Satya N. Guin. Ananya Banik. Subhajit. Roychowdhury. Manisha Samanta Ekashmi. Rathore. Sujoy Saha. Thermoelectrics. Guin et al. Energy Environ. Sci., 2013, 6, 2603. Guin et al. J. Mater. Chem. A 2014, 2, 4324. Guin, et al. J. Am. Chem.

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Effects of non-local thermodynamic equilibrium (non-LTE) condition on emission and hydrodynamics of typical inertial confinement fusion (ICF) plasmas are studied. The average degree of ionization at high temperatures is seen to be much lower compared to the values obtained from Thomas–Fermi scaling or Saha ...

Climate Forecast System

Science.gov (United States)

Weather Service NWS logo - Click to go to the NWS home page Climate Forecast System Home News Organization Web portal to all Federal, state and local government Web resources and services. The NCEP Climate when using the CFS Reanalysis (CFSR) data. Saha, Suranjana, and Coauthors, 2010: The NCEP Climate

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

pp 125-142. Kinematics of large scale asymmetric folds and associated smaller scale brittle-ductile structures in the Proterozoic Somnur Formation, Pranhita - Godavari valley, south India · Gautam Ghosh Dilip Saha · More Details Abstract Fulltext PDF. The development of structural elements and finite strain data are ...

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Sadhana. Ankit Shrivastava. Articles written in Sadhana. Volume 40 Issue 3 May 2015 pp 769-785 Section I – Fluid Mechanics and Fluid Power (FMFP). Suppression of vortex shedding around a square cylinder using blowing · Arun K Saha Ankit Shrivastava · More Details Abstract Fulltext PDF.

Ionizing Shocks in Argon. Part 1: Collisional-Radiative Model and Steady-State Structure (Preprint)

Science.gov (United States)

2010-09-09

absorption oscillator strength is given by fabsij = gj gi Aji 3γ . (43) Contributions to the parameter γ have been assumed to result from a combination of...discretization, the Saha temperatures of the higher states (green, red and blue solid curves) overshoot Te and relaxes with Th, indicating over

Short Communication: Prevalence of hypertension and variation of ...

African Journals Online (AJOL)

Short Communication: Prevalence of hypertension and variation of blood pressure with age among adolescents in Chetla, India. I Saha, B Paul, A Dasgupta. Abstract. This community-based cross-sectional study was carried out to determine the prevalence of hypertension and variation of blood pressure with age among ...

Mondal, Prof. Naba Kumar

Indian Academy of Sciences (India)

Mondal, Prof. Naba Kumar Ph.D. (Bombay) D.Sc. (h.c.), FNA, FNASc, FTWAS. Date of birth: 11 March 1951. Specialization: Experimental Particle Physics, Accelerator-based Particle Physics and Neutrino Physics Address: Raja Ramanna Fellow, Saha Institute of Nuclear Physics, 1/AF, Bidhan Nagar, Kolkata 700 064, W.B.

Is the Human Development Index (HDI) of the United Nations ...

African Journals Online (AJOL)

Is the Human Development Index (HDI) of the United Nations Development Programme (UNDP) a relevant indicator? Jean Claude Saha. Abstract. No Abstract. African Journal of Economic Policy Vol. 12(1) 2005: 1-27. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

Measurement of the argon plasma temperature by use of pyrometer

International Nuclear Information System (INIS)

Wang Fanhou; Jing Fuqian

2002-01-01

The author describes in detail how to use pyrometer to measure the plasma temperature. The temperatures of shock-generated argon plasmas are given in the present work. Measured results of temperature-pressure curve are compared with calculated results using Saha-Debye-Huckel model, which are in good agreement

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Earth System Science. Anup Saha. Articles written in Journal of Earth System Science. Volume 125 Issue 4 June 2016 pp 885-895. Effect of irregularity on torsional surface waves in an initially stressed anisotropic porous layer sandwiched between homogeneous and non-homogeneous half- ...

New benzothiazole/thiazole-containing hydroxamic acids as potent histone deacetylase inhibitors and antitumor agents

DEFF Research Database (Denmark)

Thanh Tung, Truong; Oanh, Dao Thi Kim; Dung, Phan Thi Phuong

2013-01-01

Results from clinical studies have demonstrated that inhibitors of histone deacetylase (HDAC) enzymes possess promise for the treatment of several types of cancer. Zolinza(®) (widely known as SAHA) has been approved by the FDA for the treatment of T-cell lymphoma. As a continuity of our ongoing...

from First-principles study to Materials Modeling Tanusri Saha ...

Indian Academy of Sciences (India)

MOTIVATION. • Novel materials are key to new technologies. • Modeling is playing an ever increasing role in the search for new materials. • The chemistry controls the physical properties (e.g. electrical, magnetic, and optical properties) of materials. At the root of all are the Electrons! . – p.3/25 ...

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Sadhana. Saurabh Aggarwal. Articles written in Sadhana. Volume 39 Issue 4 August 2014 pp 843-858. Give-and-take based peer-to-peer content distribution networks · Saurabh Aggarwal Joy Kuri Chandan Saha · More Details Abstract Fulltext PDF. Content Distribution Networks (CDNs) are widely used to ...

Cu(dmen)

Indian Academy of Sciences (India)

Administrator

N MONDAL, M K SAHA, B BAG and S MITRA. Department of Chemistry, Jadavpur University, Calcutta 700 032, India. The chemistry of several bimetallic assemblies has developed recently due to their variable magnetic properties 1. Among them a cyanide system based on prussian blue and its analogues is particularly ...

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Pramana – Journal of Physics; Volume 68; Issue 3. Effects of barrier fluctuation on the tunneling dynamics in the presence of classical chaos in a mixed quantum-classical system. Aparna Saha Bidhan Chandra Bag Pranab Sarkar. Research Articles Volume 68 Issue 3 March 2007 pp 377-387 ...

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

pp 1421-1440. Simultaneous estimation of earthquake source parameters and crustal value from broadband data of selected aftershocks of the 2001 7.7 Bhuj earthquake · A Saha S Lijesh P Mandal · More Details Abstract Fulltext PDF. This paper presents the simultaneous estimation of source parameters and crustal ...

Lost Talent? The Occupational Ambitions and Attainments of Young Australians

Science.gov (United States)

Sikora, Joanna; Saha, Lawrence J.

2011-01-01

Given ongoing interest in increasing productivity and participation in the workforce, understanding when talent is lost is a useful exercise. The term "lost talent" describes the underutilisation or wastage of human potential. Focusing on young people, Sikora and Saha define lost talent as occurring when students in the top 50% of…

Quarkonia production at forward rapidity in Pb+Pb collisions at ...

Indian Academy of Sciences (India)

2012-10-02

Oct 2, 2012 ... Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700 064, India .... However, the midrapidity values at 200 GeV. *> part.

Fulltext PDF

Indian Academy of Sciences (India)

The National Conference on X-Ray Fluorescence, XRF-2010, held at Saha Institute of. Nuclear Physics, Kolkata from January 12 to 15, 2010, was organized with the intention of presenting the latest developments in the field of X-Ray Fluorescence and to stimulate fruitful discussions amongst the researchers in our country.

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Nickel(II) complexes having Imidazol-2-ylidene-N′-phenylurea ligand in the coordination sphere – syntheses and solid state structures · Kishor Naktode Abhinanda Kundu Sudeshna Saha Hari Pada Nayek Tarun K Panda · More Details Abstract Fulltext PDF. We report the syntheses and structural studies of two nickel(II) ...

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Pramana – Journal of Physics. Pinaki Patra. Articles written in Pramana – Journal of Physics. Volume 80 Issue 1 January 2013 pp 21-30 Research Articles. SUSY formalism for the symmetric double well potential · Pinaki Patra Abhijit Dutta Jyoti Prasad Saha · More Details Abstract Fulltext PDF. Using first- ...

Effect of different plant hormones on callus induction in Gymnema ...

African Journals Online (AJOL)

STORAGESEVER

2008-07-04

Jul 4, 2008 ... The tissue cultures of medicinal plants have a wide range of industrial application (Ghosh, 2005). Explant sterilization is a major step in culture establishment of perennial trees or shrub. Proper concentration of sterili- zing agent is a key factor (Roy and Saha, 1997). This was determined by applying different ...

Fulltext PDF

Indian Academy of Sciences (India)

28 "That which we call a rose by any other name would smell as sweet": How the Nose knows! Nobel Prize in Physiology or Medicine 2004. Sayanti Saha, Parvathy Ramakrishnan and. Sandhya S Visweswariah. 35 Einstein's Miraculous Year. Vasant Natarajan, V Balakrishnan and N Mukunda. 57 Quality of Service in the ...

Journal of Fundamental and Applied Sciences - Vol 3, No 2 (2011)

African Journals Online (AJOL)

Square wave voltammetric determination of lead in commercial kohl using a glassy carbon electrode · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. MA Saha, M Alia, A Rebiai, T Lanez, 155-164. http://dx.doi.org/10.4314/jfas.v3i2.4 ...

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

pp 377-387 Research Articles. Effects of barrier fluctuation on the tunneling dynamics in the presence of classical chaos in a mixed quantum-classical system · Aparna Saha Bidhan Chandra Bag Pranab Sarkar · More Details Abstract Fulltext PDF. We present a numerical investigation of the tunneling dynamics of a particle ...

Mitigation Strategies to Reduce Truck Crash Rates on Wyoming Highways

Science.gov (United States)

2017-05-04

M Mahdi Rezapour Mashhadi (ORCID iD: 0000-0003-0774-737X); Promothes Saha, Ph.D., P.E. (ORCID iD: 0000-0003-3298-8327); Trenna Terrill (ORCID iD: 0000-0002-5239-6380); Khaled Ksaibati, Ph.D., P.E. (ORCID iD: 0000-0003-3532-6839) Wyoming has one of th...

" That which we call a rose by any other name would smell as sweet ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 10; Issue 3. “That which we call a rose by any other name would smell as sweet”: How the Nose knows! - Nobel Prize in Physiology or Medicine 2004. Sayanti Saha Parvathy Ramakrishnan Sandhya S Visweswariah. General Article Volume 10 Issue 3 ...

Study of equation-of-state of dense helium

International Nuclear Information System (INIS)

Cai Lingcang; Zhang Lin; Xiang Shikai; Jing Fuqian

2001-01-01

Hugoniot EOS, shock temperature of gas helium plasma (the initial pressure is 1.2 MPa and the initial temperature is 293 K) are measured with the help of shock compression technique and transient radiation pyrometer. The experimental Hugoniot data are good agreement with the theoretical prediction by Saha equation pus Debye-Huckel correction

S Chatterjee

Indian Academy of Sciences (India)

Modified technique of using conventional slider boat for liquid phase epitaxy of silicon for solar cell application · D Majumdar S Chatterjee U Gangopadhyay H Saha ... 2008 pp 433-439. Studies on crystallization behaviour and mechanical properties of Al–Ni–La metallic glasses · K L Sahoo Rina Sahu M Ghosh S Chatterjee.

Resonance – Journal of Science Education | Indian Academy of ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 21; Issue 12. Mycorrhiza: The Oldest ... Babita Saha Siraj Datta. General Article Volume 21 Issue 12 December 2016 pp 1093-1104. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/021/12/1093-1104 ...

Fusion–fission dynamics studies using mass distribution as a probe

Indian Academy of Sciences (India)

2015-08-02

Aug 2, 2015 ... 2Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700 064, India ... Abstract. Study of quasifission reaction mechanism and shell effects in compound nuclei has .... The dotted line is to guide the eye [14]. .... Ramamurthy et al [24] have shown that shell effects on nuclear level density parameter.

Spectrophotometry of comets Giacobini-Zinner and Halley

International Nuclear Information System (INIS)

Tegler, S.C.; O'dell, C.R.

1987-01-01

Optical window spectrophotometry was performed on comets Giacobini-Zinner and Halley over the interval 300-1000 nm. Band and band-sequence fluxes were obtained for the brightest features of OH, CN, NH, and C2, special care having been given to determinations of extinction, instrumental sensitivities, and corrections for Fraunhofer lines. C2 Swan band-sequence flux ratios were determined with unprecedented accuracy and compared with the predictions of the detailed equilibrium models of Krishna Swamy et al. (1977, 1979, 1981, and 1987). It is found that these band sequences do not agree with the predictions, which calls into question the assumptions made in deriving the model, namely resonance fluorescence statistical equilibrium. Suggestions are made as to how to resolve this discrepancy. 16 references

Spectrophotometry of comets Giacobini-Zinner and Halley

Science.gov (United States)

Tegler, Stephen C.; O'Dell, C. R.

1987-01-01

Optical window spectrophotometry was performed on comets Giacobini-Zinner and Halley over the interval 300-1000 nm. Band and band-sequence fluxes were obtained for the brightest features of OH, CN, NH, and C2, special care having been given to determinations of extinction, instrumental sensitivities, and corrections for Fraunhofer lines. C2 Swan band-sequence flux ratios were determined with unprecedented accuracy and compared with the predictions of the detailed equilibrium models of Krishna Swamy et al. (1977, 1979, 1981, and 1987). It is found that these band sequences do not agree with the predictions, which calls into question the assumptions made in deriving the model, namely resonance fluorescence statistical equilibrium. Suggestions are made as to how to resolve this discrepancy.

Improving the organic and biological fouling resistance and removal of pharmaceutical and personal care products through nanofiltration by using in situ radical graft polymerization.

Science.gov (United States)

Lin, Yi-Li; Tsai, Chia-Cheng; Zheng, Nai-Yun

2018-09-01

In this study, an insitu radical graft polarization technique using monomers of 3-sulfopropyl methacrylate potassium salt (SPM) and 2-hydroxyethyl methacrylate (HEMA) was applied to a commercial nanofiltration membrane (NF90) to improve its removal of six commonly detected pharmaceutical and personal care products (PPCPs) and mitigate organic and biological fouling by humic acid (HA) and sodium alginate (SA). Compared with the virgin membrane, the modified NF90 membrane exhibited considerably improved fouling resistance and an increased reversible fouling percentage, especially for SA+HA composite fouling Moreover, the PPCP removal of the modified NF90 membrane was higher than that of the virgin membrane after SA and SA+HA fouling, respectively. Triclosan and carbamazepine, which are poorly rejected, could be effectively removed by modified membrane after SA or SA+HA fouling. Both monomers modified the membrane surface by increasing the hydrophilicity and decreasing the contact angle. The degree of grafting was quantified using attenuated total reflection Fourier-transform infrared spectroscopy. The mitigation in the fouling was evident from the low quantity of deposit formed on the modified membrane, as observed using scanning electron microscopy. A considerable amount of highly hydrophobic triclosan was adsorbed on the SA-fouled virgin membrane and penetrated through it. By contrast, the adsorption of triclosan was substantially lower in the SPM-modified membrane. After membrane modification, the fouling mechanism changed from solely intermediate blocking to both intermediate blocking and complete blocking after membrane modification. Thus, the in situ radical graft polymerization method effectively reduces organic and biological fouling and provides high PPCP removal, which is beneficial for fouling control and produces permeate of satisfactory quality for application in the field of membrane technology. Copyright © 2018 Elsevier B.V. All rights reserved.

Transformation products formation of ciprofloxacin in UVA/LED and UVA/LED/TiO2 systems: Impact of natural organic matter characteristics.

Science.gov (United States)

Li, Si; Hu, Jiangyong

2018-04-01

The role of natural organic matter (NOM) in contaminants removal by photolysis and photocatalysis has aroused increasing interest. However, evaluation of the influence of NOM characteristics on the transformation products (TPs) formation and transformation pathways of contaminants has rarely been performed. This study investigated the decomposition kinetics, mineralization, TPs formation and transformation pathways of antibiotic ciprofloxacin (CIP) during photolysis and photocatalysis in the presence of three commercial NOM isolates (Sigma-Aldrich humic acid (SAHA), Suwannee River humic acid (SRHA) and Suwannee River NOM (SRNOM)) by using UVA light emitting diode (UVA/LED) as an alternative light source. NOM isolates insignificantly affected CIP photolysis but strongly inhibited CIP photocatalysis due to competitive radical quenching. The inhibitory effect followed the order of SAHA (49.6%) > SRHA (29.9%) > SRNOM (21.2%), consistent with their •OH quenching abilities, SUVA 254 values and orders of aromaticity. Mineralization rates as revealed by F - release were negatively affected by NOM during CIP photocatalysis. TPs arising from hydroxylation and defluorination were generally suppressed by NOM isolates in UVA/LED and UVA/LED/TiO 2 systems. In contrast, dealkylation and oxidation of piperazine ring were promoted by NOM. The enhancement in the apparent formation kinetics (k app ) of TP245, TP291, TP334a, TP334b and TP362 followed the order of SRNOM > SRHA > SAHA. k app values were positively correlated with O/C ratio, carboxyl content, E2/E3 and fluorescence index (FI) of NOM and negatively related with SUVA 254 values. The observed correlations indicate that NOM properties are important in determining the fate and transformation of organic contaminants during photolysis and photocatalysis. Copyright © 2018 Elsevier Ltd. All rights reserved.

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Earth System Science; Volume 122; Issue 1. Contribution of some ozone depleting substances (ODS) and greenhouse gases (GHGs) on total column zone growth at Srinagar (34°N, 74.8°), India. P K Jana D K Saha D Sarkar. Volume 122 Issue 1 February 2013 pp 239-252 ...

Fulltext PDF

Indian Academy of Sciences (India)

J C Bose and P C Ray, they both did work of path-breaking quality and importance. Rajaram Nityananda sketches the physical ideas behind Saha's 1920 ionisation formula. Only after this did the subject of astrophysics really get going, relating properties of the elements as known on the earth to what goes on in stars.

Antisocial Behavior in Adolescence: Typology and Relation to Family Context

Science.gov (United States)

Sobotková, Veronika; Blatný, Marek; Jelínek, Martin; Hrdlicka, Michal

2013-01-01

The study deals with the relationship between antisocial behavior in early adolescence and family environment. Sample consisted of 2,856 adolescents (53% girls, mean age 13.5 years, SD = 1.1) from urban areas in the Czech Republic. The Social and Health Assessment (SAHA), a school survey, was used to measure sociodemographic characteristics of the…

Resonance – Journal of Science Education | News

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 3; Issue 5. Issue front cover thumbnail Issue back cover thumbnail. Volume 3, Issue 5. May 1998, pages 1-98. pp 1-1 Editorial. Editorial · N Mukunda · More Details Fulltext PDF. pp 2-2 Article-in-a-Box. Thermal Ionisation and the Saha Equation!

Concurrent Enrollment: Comparing How Educators and Students Categorize Students' Motivations

Science.gov (United States)

Dare, Alec; Dare, Lynn; Nowicki, Elizabeth

2017-01-01

High-ability students have special education needs that are often overlooked or misunderstood (Blaas in "Aust J Guid Couns" 24(2):243-255, 2014) which may result in talent loss (Saha and Sikora in "Int J Contemp Sociol Discuss J Contemp Ideas Res" 48(1):9-34, 2011). Educational acceleration can help avoid these circumstances…

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Pramana – Journal of Physics. S Sarkar. Articles written in Pramana – Journal of Physics. Volume 57 Issue 1 July 2001 pp 165-169 Contributed Papers : Nuclear spectroscopy. Level structures ofMo – A comparative study · J M Chatterjee M Saha Sarkar S Bhattacharya P Banerjee S Sarkar R P Singh S ...

Study of the stacked plasma generator of Maecker type

International Nuclear Information System (INIS)

Shirai, Hiroyuki; Tabei, Katsuine; Machida, Ichiro; Ishihara, Kimio.

1981-01-01

An experimental investigation of a stacked plasma generator of Maecker type has been performed at low pressures (25 - 760 Torr) and low electric currents (10 - 60 A) for argon gas. Radial distributions of electron density and electron temperature were obtained by measuring the intensities of spectral lines and continuum from cylindrically confined plasmas. Based on such data of the macroscopic plasma parameters, the SAHA equilibrium relation, and the collisional and radiative theory of BATES et al., the spatial extent of equilibrium region and nonequilibrium effects of electronic excitation of the atom have been examined. In the plasmas generated in the apparatus, electron temperature ranged from 7,500 to 11,000 0 K and electron density 7 x 10 14 to 3 x 10 16 cm -3 . It was found that thermochemical equilibrium conditions existed only in the vicinity of the tube axis even at relatively high pressures and high currents, and the higher excited levels than the 5p level of argon atom were always in SAHA equilibrium with free electrons. (author)

Lidar observation of aerosol stratification in the lower troposphere ...

Indian Academy of Sciences (India)

S K Saha, S M Sonbawne, S M Deshpande, P C S Devara,. Y Jaya Rao .... The lidar system operated in bistatic mode essen- tially comprises a .... with this system at 1700hrs Local Time (LT) on all the ..... Pune in operating the wind profiler system and. Dr. (Mrs.) ... 1995 Real-time monitoring of atmospheric aerosols using a ...

Kamuflaažmaja / Mihkel Karu

Index Scriptorium Estoniae

Karu, Mihkel, 1983-

2013-01-01

Oskuslikult mändide vahele sobitatud eramu Tallinna lähedal. Arhitektid Illimar Truverk ja Priit Hamer (Arhitekt11/Agabus, Endjärv & Truverj Arhitektid). Sisearhitektid Külli Salum ja Riina Harik (Saha In). Veel lõplikult teostamata maastikuarhitektuurse lahenduse kavandasid Kätlin Ölluk ja Kadi Markna. Ehitusaeg: 2010-2012. Elamispind: 409/160 m²

Hotell Telegraaf = Hotel Telegraaf

Index Scriptorium Estoniae

2008-01-01

Hotelli Telegraaf (Vene 9, Tallinn) sisekujundus, mis pälvis Eesti Sisearhitektide Liidu 2007. a. ajaloolise interjööri preemia. Juurdeehitise arhitekt: Martin Aunin. Sisearhitektid: Külli Salum ja Riina Harik (SAHA IN OÜ). Sisearhitektidest, nende tähtsamad tööd. I ja II korruse plaan, värv. välisvaade, 18 sisevaadet, fotod sisearhitektidest

Dynamics of interaction of ultrashort laser pulses with solid targets

International Nuclear Information System (INIS)

Cang Yu; Wang Wei; Zhang Jie

2001-01-01

Using Saha equation, a simple model is proposed for the dynamics of interaction between ultrashort laser pulses and solid targets. An adiabatic expansion model is adopted to study the expansion phase after the heating phase. Temporal evolvement of the dynamics of the interaction is obtained, from which the electron temperature, density, ionization balances can be determined

The Origin of Mass in Neutrons and Protons

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 3; Issue 5. The Origin of Mass in Neutrons and Protons. M N Saha. Classics Volume 3 Issue 5 May 1998 pp 84-96. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/003/05/0084-0096. Author Affiliations.

P L Bhatnagar (1912–1976)

Indian Academy of Sciences (India)

IAS Admin

M N Saha. Bhatnagar began to work on the spiral nebula and the tidal theory of planetary formation. He obtained the DPhil degree in mathematics in 1939 for his thesis entitled 'On the origin of the solar system' under the supervision of Prof. A C Banerji. Prof. S N Mukherjee, the then Principal of St. Stephen's College, Delhi, ...

k c mistri

Indian Academy of Sciences (India)

Home; Journals; Sadhana. K C MISTRI. Articles written in Sadhana. Volume 42 Issue 9 September 2017 pp 1459-1471. Influence of yielding base and rigid base on propagation of Rayleigh-type wave in a viscoelastic layer of Voigt type · S SAHA A CHATTOPADHYAY K C MISTRI A K SINGH · More Details Abstract Fulltext ...

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Earth System Science; Volume 126; Issue 5. Assessment of large aperture scintillometry for large-area surface energy fluxes over an irrigated cropland in north India. Abhishek Danodia V K Sehgal N R Patel R Dhakar J Mukherjee S K Saha A Senthil Kumar. Volume 126 Issue 5 July 2017 Article ...

Robotics for waste storage inspection: A user's perspective

International Nuclear Information System (INIS)

Hazen, F.B.

1994-01-01

Self-navigating robotic vehicles are now commercially available, and the technology supporting other important system components has also matured. Higher reliability and the obtainability of system support now make it practical to consider robotics as a way of addressing the growing operational requirement for the periodic inspection and maintenance of radioactive, hazardous, and mixed waste inventories. This paper describes preparations for the first field deployment of an autonomous container inspection robot at a Department of Energy (DOE) site. The Stored Waste Autonomous Mobile Inspector (SWAMI) is presently being completed by engineers at the Savannah River Technology Center (SRTC). It is a modified version of a commercially available robot. It has been outfitted with sensor suites and cognition that allow it to perform inspections of drum inventories and their storage facilities

Use of Langmuir probe for analysis of charged particles in metal vapour generated by electron beam heating

International Nuclear Information System (INIS)

Dikshit, B; Bhatia, M S

2008-01-01

During electron beam evaporation of metal, a certain fraction of the vapor is ionized due to various processes such as Saha ionization and electron impact. These charge particles constitute a plasma which expands along with the vapour. To know about parameters of this plasma viz. electron temperature, electron density, plasma potential, we have used a disc type Langmuir probe inside the plasma. The measured electron temperature was found to be about ∼0.15eV (1740K) and measured plasma potential was ∼1V. The low value of electron temperature as compared to the source temperature, established that plasma cools significantly while traversing the distance between the source and the point of measurement. Again as the electron temperature was approximately same as the ion temperature of the vapor (expected to be same as kinetic temperature of vapor for collisional flow), we concluded that a kind of equilibrium had been established in the plasma. Finally, various processes responsible for ionization of the vapor are discussed and it was found that both Saha ionization and electron impact processes play important role in ionization of the uranium vapor generated by electron beam heating

Suberoylanilide hydroxamic acid increases progranulin production in iPSC-derived cortical neurons of frontotemporal dementia patients.

Science.gov (United States)

Almeida, Sandra; Gao, Fuying; Coppola, Giovanni; Gao, Fen-Biao

2016-06-01

Mutations in the granulin (GRN) gene cause frontotemporal dementia (FTD) due to progranulin haploinsufficiency. Compounds that can increase progranulin production and secretion may be considered as potential therapeutic drugs; however, very few of them have been directly tested on human cortical neurons. To this end, we differentiated 9 induced pluripotent stem cell lines derived from a control subject, a sporadic FTD case and an FTD patient with progranulin S116X mutation. Treatment with 1 μM suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, increased the production of progranulin in cortical neurons of all subjects at both the mRNA and protein levels without affecting their viability. Microarray analysis revealed that SAHA treatment not only reversed some gene expression changes caused by progranulin haploinsufficiency but also caused massive alterations in the overall transcriptome. Thus, histone deacetylase inhibitors may be considered as therapeutic drugs for GRN mutation carriers. However, this class of drugs also causes drastic changes in overall gene expression in human cortical neurons and their side effects and potential impacts on other pathways should be carefully evaluated. Copyright © 2016 Elsevier Inc. All rights reserved.

Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.

Science.gov (United States)

Pavlik, Christopher M; Wong, Christina Y B; Ononye, Sophia; Lopez, Dioxelis D; Engene, Niclas; McPhail, Kerry L; Gerwick, William H; Balunas, Marcy J

2013-11-22

A dark brown tuft-forming cyanobacterium, morphologically resembling the genus Symploca, was collected during an expedition to the Coiba National Park, a UNESCO World Heritage Site on the Pacific coast of Panama. Phylogenetic analysis of its 16S rRNA gene sequence indicated that it is 4.5% divergent from the type strain for Symploca and thus is likely a new genus. Fractionation of the crude extract led to the isolation of a new cytotoxin, designated santacruzamate A (1), which has several structural features in common with suberoylanilide hydroxamic acid [(2), SAHA, trade name Vorinostat], a clinically approved histone deacetylase (HDAC) inhibitor used to treat refractory cutaneous T-cell lymphoma. Recognition of the structural similarly of 1 and SAHA led to the characterization of santacruzamate A as a picomolar level selective inhibitor of HDAC2, a Class I HDAC, with relatively little inhibition of HDAC4 or HDAC6, both Class II HDACs. As a result, chemical syntheses of santacruzamate A as well as a structurally intriguing hybrid molecule, which blends aspects of both agents (1 and 2), were achieved and evaluated for their HDAC activity and specificity.

Santacruzamate A, a Potent and Selective Histone Deacetylase (HDAC) Inhibitor from the Panamanian Marine Cyanobacterium cf. Symploca sp.

Science.gov (United States)

Pavlik, Christopher M.; Wong, Christina Y.B.; Ononye, Sophia; Lopez, Dioxelis D.; Engene, Niclas; McPhail, Kerry L.; Gerwick, William H.; Balunas, Marcy J.

2013-01-01

A dark-brown tuft-forming cyanobacterium, morphologically resembling the genus Symploca, was collected during an expedition to the Coiba National Park, a UNESCO World Heritage Site on the Pacific coast of Panama. Phylogenetic analysis of its 16S rRNA gene sequence indicated that it is 4.5% divergent from the type strain for Symploca, and thus is likely a new genus. Fractionation of the crude extract led to the isolation of a new cytotoxin, designated santacruzamate A (1), which has several structural features in common with suberoylanilide hydroxamic acid [(2), SAHA, trade name Vorinostat®], a clinically approved histone deacetylase (HDAC) inhibitor used to treat refractory cutaneous T-cell lymphoma. Recognition of the structural similarly of 1 and SAHA led to the characterization of santacruzamate A as a picomolar level selective inhibitor of HDAC2, a Class I HDAC, with relatively little inhibition of HDAC4 or HDAC6, both Class II HDACs. As a result, chemical syntheses of santacruzamate A as well as a structurally intriguing hybrid molecule, which blends aspects of both agents (1 and 2), were achieved and evaluated for their HDAC activity and specificity. PMID:24164245

Analysis of two-phase flow instability in vertical boiling channels I: development of a linear model for the inlet velocity perturbation

International Nuclear Information System (INIS)

Hwang, D.H.; Yoo, Y.J.; Kim, K.K.

1998-08-01

A linear model, named ALFS, is developed for the analysis of two-phase flow instabilities caused by density wave oscillation and flow excursion in a vertical boiling channel with constant pressure drop conditions. The ALFS code can take into account the effect of the phase velocity difference and the thermally non-equilibrium phenomena, and the neutral boundary of the two-phase flow instability was analyzed by D-partition method. Three representative two-phase flow models ( i.e. HEM, DEM, and DNEM) were examined to investigate the effects on the stability analysis. As the results, it reveals that HEM shows the most conservative prediction of heat flux at the onset of flow instability. three linear models, Ishiis DEM, Sahas DNEM, and ALFS model, were applied to Sahas experimental data of density wave oscillation, and as the result, the mean and standard deviation of the predicted-to-measured heat flux at the onset of instability were calculated as 0.93/0.162, 0.79/0.112, and 0.95/0.143, respectively. For the long test section, however, ALFS model tends to predict the heat fluxes about 30 % lower than the measured values. (author). 14 refs

Short outlines of books by Estonian authors / Brita Melts, Rutt Hinrikus, Maire Iro and Maret Vaher

Index Scriptorium Estoniae

2013-01-01

Arvustus: Pärtna, Maarja. Läved ja tüved. Tallinn : Eesti Keele Sihtasutus, 2013 ; Sauter, Peeter. Ära jäta mind rahule. Tallinn : P. Sauter, 2012 ; Viiding, Elo. Teised. Tallinn : Tuum, 2012 ; Mathura. Kumalasepäev. Lelle : Allikaäärne, 2012 ; Kadastik, Mart. Kevad saabub sügisel. Tallinn : Varrak, 2013 ; Mutt, Mihkel. Kooparahvas läheb ajalukku. Tallinn : Fabian, 2012 ; Hargla, Indrek. Apteeker Melchior ja Pirita kägistaja. Tallinn : Varrak, 2013 ; Raud, Rein. Rekonstruktsioon. Tallinn : Mustvalge Kirjastus, 2012 ; Toona, Elin. Into exile : a life story of war and peace. Woodsville (N.H.) : Lakeshore Press, 2013 ; Berg, Maimu. Moemaja. Tartu : Petrone Print, 2012 ; Kareva, Doris, Rooste, Jürgen. Elutants. Tallinn : Verb, 2013 ; Ehin, Kristiina. Paleontoloogi päevaraamat. Tartu : Petrone Print, 2013 ; Maria Lee. Stereomeetria. Tallinn : Verb, 2012

Quadrature-Quadrature Phase Shift Keying.

Science.gov (United States)

1986-09-01

SECURITY CLASSIFICATION OF -IS PAfr All other editions are obsolete ’r- Ac P..N -N- %.. .. V . .. b . h S Debabrata Saha 1986 All Rights Reserved...1.2/T T~,pe of AISA Q -PSK AMSK 0 Y(IitIo ?6 orthogonal Four -level F, J." 𔃻 1i 1/ 2 H13.4 a H P6 E 44 3.5 Modulator Demodulator and Synchronization

Epigenetic regulation of vascular NADPH oxidase expression and reactive oxygen species production by histone deacetylase-dependent mechanisms in experimental diabetes

Directory of Open Access Journals (Sweden)

Simona-Adriana Manea

2018-06-01

Full Text Available Reactive oxygen species (ROS generated by up-regulated NADPH oxidase (Nox contribute to structural-functional alterations of the vascular wall in diabetes. Epigenetic mechanisms, such as histone acetylation, emerged as important regulators of gene expression in cardiovascular disorders. Since their role in diabetes is still elusive we hypothesized that histone deacetylase (HDAC-dependent mechanisms could mediate vascular Nox overexpression in diabetic conditions. Non-diabetic and streptozotocin-induced diabetic C57BL/6J mice were randomized to receive vehicle or suberoylanilide hydroxamic acid (SAHA, a pan-HDAC inhibitor. In vitro studies were performed on a human aortic smooth muscle cell (SMC line. Aortic SMCs typically express Nox1, Nox4, and Nox5 subtypes. HDAC1 and HDAC2 proteins along with Nox1, Nox2, and Nox4 levels were found significantly elevated in the aortas of diabetic mice compared to non-diabetic animals. Treatment of diabetic mice with SAHA mitigated the aortic expression of Nox1, Nox2, and Nox4 subtypes and NADPH-stimulated ROS production. High concentrations of glucose increased HDAC1 and HDAC2 protein levels in cultured SMCs. SAHA significantly reduced the high glucose-induced Nox1/4/5 expression, ROS production, and the formation malondialdehyde-protein adducts in SMCs. Overexpression of HDAC2 up-regulated the Nox1/4/5 gene promoter activities in SMCs. Physical interactions of HDAC1/2 and p300 proteins with Nox1/4/5 promoters were detected at the sites of active transcription. High glucose induced histone H3K27 acetylation enrichment at the promoters of Nox1/4/5 genes in SMCs. The novel data of this study indicate that HDACs mediate vascular Nox up-regulation in diabetes. HDAC inhibition reduces vascular ROS production in experimental diabetes, possibly by a mechanism involving negative regulation of Nox expression. Keywords: NADPH oxidase, Epigenetics, HDAC, Histone acetylation, Diabetes

Helilooja Arvo Pärt jäi Pärnu kontserdiga väga rahule / Ester Vilgats

Index Scriptorium Estoniae

Vilgats, Ester

2007-01-01

Pärnu Filharmoonia ja kontserdimaja hooaja avakontserdist "Pärt Pärnus" 22. sept. Pärnu kontserdimajas, esitusel Arvo Pärdi teosed "Te Deum", "Tabula rasa", "Ein Wallfahrtslied" ja "Orient & Occident"

Journal of Earth System Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Yearly variation and annual cycle of total column ozone over New Delhi (29°N, 77°E), India and Halley Bay (76°S, 27°W), British Antarctic Survey Station and its effect on night airglow intensity of OH(8, 3) for the period 1979–2005 · P K Jana D K Saha D Sarkar · More Details Abstract Fulltext PDF. A critical analysis made on ...

Long- Range Forecasting Of The Onset Of Southwest Monsoon Winds And Waves Near The Horn Of Africa

Science.gov (United States)

2017-12-01

conditions is also indicated ( S : strong, M: moderate, W: weak). ..............34 xi LIST OF TABLES Table 1. Table of correlation experiments conducted...2nd ed.). Essex, England: Pearson prentice hall, 317 pp. Saha, S ., and Coauthors, 2010: NCEP Climate Forecast System Reanalysis (CFSR) Selected...WAVES NEAR THE HORN OF AFRICA 5. FUNDING NUMBERS 6. AUTHOR( S ) Gary M. Vines 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Naval Postgraduate

A Distributed Approach to System-Level Prognostics

Science.gov (United States)

2012-09-01

the end of (useful) life ( EOL ) and/or the remaining useful life (RUL) of components, subsystems, or systems. The prognostics problem itself can be...system state estimate, computes EOL and/or RUL. In this paper, we focus on a model-based prognostics approach (Orchard & Vachtse- vanos, 2009; Daigle...been focused on individual components, and determining their EOL and RUL, e.g., (Orchard & Vachtsevanos, 2009; Saha & Goebel, 2009; Daigle & Goebel

Deviations from thermal equilibrium in plasmas

International Nuclear Information System (INIS)

Burm, K.T.A.L.

2004-01-01

A plasma system in local thermal equilibrium can usually be described with only two parameters. To describe deviations from equilibrium two extra parameters are needed. However, it will be shown that deviations from temperature equilibrium and deviations from Saha equilibrium depend on one another. As a result, non-equilibrium plasmas can be described with three parameters. This reduction in parameter space will ease the plasma describing effort enormously

X-ray fluorescence activities at Saha Institute of Nuclear Physics, India

Indian Academy of Sciences (India)

X-ray fluorescence (EDXRF) system was developed to analyse alloys by exposing them directly under the tube bremsstrahlung .... A detailed description of the analysis of these data is given in [11]. ..... samples were first dried, ground in an agate mortar with pestle, and if necessary, mixed with a binder to make pellets in a ...

Fractional factorial plans

CERN Document Server

Dey, Aloke

2009-01-01

A one-stop reference to fractional factorials and related orthogonal arrays.Presenting one of the most dynamic areas of statistical research, this book offers a systematic, rigorous, and up-to-date treatment of fractional factorial designs and related combinatorial mathematics. Leading statisticians Aloke Dey and Rahul Mukerjee consolidate vast amounts of material from the professional literature--expertly weaving fractional replication, orthogonal arrays, and optimality aspects. They develop the basic theory of fractional factorials using the calculus of factorial arrangements, thereby providing a unified approach to the study of fractional factorial plans. An indispensable guide for statisticians in research and industry as well as for graduate students, Fractional Factorial Plans features: * Construction procedures of symmetric and asymmetric orthogonal arrays. * Many up-to-date research results on nonexistence. * A chapter on optimal fractional factorials not based on orthogonal arrays. * Trend-free plans...

Lactose Intolerance and Symptom Pattern of Lactose Intolerance among Healthy Volunteers.

Science.gov (United States)

Saha, Madhusudan; Parveen, Irin; Shil, Bimal Chandra; Saha, Shasanka Kumar; Banik, Ranjit Kumar; Majumder, Monojit; Salam, Mahjuba Umme; Islam, Asm Nazmul

2016-01-01

To see the prevalence of lactose intolerance (LI) and related symptoms following oral lactose challenge in healthy volunteers. Symptoms of abdominal pain, nausea, borborygmi, flatulence, and diarrhea were noted for 24 hours and blood glucose was estimated at 0 hour and 30 minutes after 25 gm oral lactose load to healthy volunteers. Failure to rise blood glucose level ≥ 1.1 mmol/l at 30 minutes after lactose intake from fasting level was taken as lactose malabsorption (LM), i.e., LI. A total of 166 volunteers (123 males, 43 females) with a mean age 34.78 ± 11.45 years participated in this study. Lactose intolerance was found among 85.54% (n = 142, M = 104, F = 38). The main symptoms of LI were diarrhea (n = 83, 58.4.0%), borborygmi (n = 81, 57.04%), abdominal pain (n = 35, 24.65%), and flatulence (n = 27, 19.0%). Lactose intolerance among healthy adults may be common in Bangladesh. Diarrhea and borborygmi were mostly associated symptoms of LI. Saha M, Parveen I, Shil BC, Saha SK, Banik RK, Majumder M, Salam MU, Nazmul Islam ASM. Lactose Intolerance and Symptom Pattern of Lactose Intolerance among Healthy Volunteers. Euroasian J Hepato-Gastroenterol 2016;6(1):5-7.

In-house work on characterization of pixel chip pALPIDE

International Nuclear Information System (INIS)

Sinha, T.; Das, Dipankar; Chattopadhyay, S.; Biswas, A.; Roy, A.; Das, D.

2016-01-01

The activities of Muon Forward Tracker (MFT) for ALICE Upgrade had been started in the beginning of 2015. In this International collaboration, among 13 participating Institutes, the mechanical and the electronics technicians/engineers along with the scientists of Saha Institute of Nuclear Physics (SAHA) and Aligarh Muslim University (AMU) will constitute the Indian Collaboration. The physics programme of ALICE using MFT will be started after the Long Shutdown 2 (LS2). The physics investigation will be devoted to high precision measurements of hard probes (heavy flavour hadrons, quarkonia, photons and jets). The MFT will allow ALICE to extend the precision measurements of the heavy quark resonances. The MFT detector will be put upstream of the absorber of the MUON spectrometer i.e. much closer to the Interaction Point (IP) to add vertexing capability. The Si-tracking detectors of low-material budget will be used in MFT. The basic detection element of the MFT is the pixel sensor which is based on the CMOS monolithic pixel sensor technology. The India-MFT collaboration will be focusing on two areas. 'The Pixel Characterization Work' and 'The fabrication of Water-Cooling system of MFT detector'. In this report, we will discuss on 'The Pixel Characterization Work'

Suberoylanilide hydroxamic acid sensitizes neuroblastoma to paclitaxel by inhibiting thioredoxin-related protein 14-mediated autophagy.

Science.gov (United States)

Zhen, Zijun; Yang, Kaibin; Ye, Litong; You, Zhiyao; Chen, Rirong; Liu, Ying; He, Youjian

2017-07-01

Paclitaxel is not as effective for neuroblastoma as most of the front-line chemotherapeutics due to drug resistance. This study explored the regulatory mechanism of paclitaxel-associated autophagy and potential solutions to paclitaxel resistance in neuroblastoma. The formation of autophagic vesicles was detected by scanning transmission electron microscopy and flow cytometry. The autophagy-associated proteins were assessed by western blot. Autophagy was induced and the autophagy-associated proteins LC3-I, LC3-II, Beclin 1, and thioredoxin-related protein 14 (TRP14), were found to be upregulated in neuroblastoma cells that were exposed to paclitaxel. The inhibition of Beclin 1 or TRP14 by siRNA increased the sensitivity of the tumor cells to paclitaxel. In addition, Beclin 1-mediated autophagy was regulated by TRP14. Furthermore, the TRP14 inhibitor suberoylanilide hydroxamic acid (SAHA) downregulated paclitaxel-induced autophagy and enhanced the anticancer effects of paclitaxel in normal control cancer cells but not in cells with upregulated Beclin 1 and TRP14 expression. Our findings showed that paclitaxel-induced autophagy in neuroblastoma cells was regulated by TRP14 and that SAHA could sensitize neuroblastoma cells to paclitaxel by specifically inhibiting TRP14. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

[Lentivirus-mediated shRNA silencing of LAMP2A inhibits the proliferation of multiple myeloma cells].

Science.gov (United States)

Li, Lixuan; Li, Jia

2015-05-01

To study the effects of lentivirus-mediated short hairpin RNA (shRNA) silencing of lysosome-associated membrane protein type 2A (LAMP2A) expression on the proliferation of multiple myeloma cells. The constructed shRNA lentiviral vector was applied to infect human multiple myeloma cell line MM.1S, and stable expression cell line was obtained by puromycin screening. Western blotting was used to verify the inhibitory effect on LAMP2A protein expression. MTT assay was conducted to detect the effect of knocked-down LAMP2A on MM.1S cell proliferation, and the anti-tumor potency of suberoylanilide hydroxamic acid (SAHA) against the obtained MM.1S LAMP2A(shRNA) stable cell line. Lactate assay was performed to observe the impact of low LAMP2A expression on cell glycolysis. The stable cell line with low LAMP2A expression were obtained with the constructed human LAMP2A-shRNA lentiviral vector. Down-regulation of LAMP2A expression significantly inhibited MM.1S cell proliferation and enhanced the anti-tumor activity of SAHA. Interestingly, decreased LAMP2A expression also inhibited MM.1S cell lactic acid secretion. Down-regulation of LAMP2A expression could inhibit cell proliferation in multiple myeloma cells.

Histone Deacetylase Inhibitors Antagonize Distinct Pathways to Suppress Tumorigenesis of Embryonal Rhabdomyosarcoma.

Directory of Open Access Journals (Sweden)

Terra Vleeshouwer-Neumann

Full Text Available Embryonal rhabdomyosarcoma (ERMS is the most common soft tissue cancer in children. The prognosis of patients with relapsed or metastatic disease remains poor. ERMS genomes show few recurrent mutations, suggesting that other molecular mechanisms such as epigenetic regulation might play a major role in driving ERMS tumor biology. In this study, we have demonstrated the diverse roles of histone deacetylases (HDACs in the pathogenesis of ERMS by characterizing effects of HDAC inhibitors, trichostatin A (TSA and suberoylanilide hydroxamic acid (SAHA; also known as vorinostat in vitro and in vivo. TSA and SAHA suppress ERMS tumor growth and progression by inducing myogenic differentiation as well as reducing the self-renewal and migratory capacity of ERMS cells. Differential expression profiling and pathway analysis revealed downregulation of key oncogenic pathways upon HDAC inhibitor treatment. By gain-of-function, loss-of-function, and chromatin immunoprecipitation (ChIP studies, we show that Notch1- and EphrinB1-mediated pathways are regulated by HDACs to inhibit differentiation and enhance migratory capacity of ERMS cells, respectively. Our study demonstrates that aberrant HDAC activity plays a major role in ERMS pathogenesis. Druggable targets in the molecular pathways affected by HDAC inhibitors represent novel therapeutic options for ERMS patients.

Green chemistry using radiotracers at SINP

International Nuclear Information System (INIS)

Lahiri, Susanta

2006-01-01

Green chemistry is utilization of set of principles, which restricts the use, or generation of hazardous substances. In this aim, it is necessary to develop alternative methods, or to find greener reagents for minimum utilization of environmentally hostile substances. Radiotracers can be effectively utilized for development of such methods. This article describes the current status of Green Chemistry research using accelerator/reactor produced radionuclides at Saha Institute of Nuclear Physics, Kolkata, India. (author)

Ground-state populations of atomic hydrogen and hydrogen-like ions in nonthermal plasmas, and collisional-radiative recombination and ionization coefficients

International Nuclear Information System (INIS)

Drawin, H.W.; Emard, F.

1978-01-01

The populations of atomic hydrogen and hydrogen-like ions have been calculated using a collisional-radiative model. The global collisional-radiative excitation coefficients rsub(j)sup((0)) and rsub(j)sup((1)) valid for homogeneous-stationary and/or quasi-homogeneous quasi-stationary plasmas were published recently. The present paper contains in tabulated form the ground state populations and Saha decrements for the homogeneous stationary state, and the collisional-radiative recombination and ionization coefficients. (Auth.)

Pressure of a partially ionized hydrogen gas : numerical results from exact low temperature expansions

OpenAIRE

Alastuey , Angel; Ballenegger , Vincent

2010-01-01

8 pages; International audience; We consider a partially ionized hydrogen gas at low densities, where it reduces almost to an ideal mixture made with hydrogen atoms in their ground-state, ionized protons and ionized electrons. By performing systematic low-temperature expansions within the physical picture, in which the system is described as a quantum electron-proton plasma interacting via the Coulomb potential, exact formulae for the first five leading corrections to the ideal Saha equation ...

M.O.T.T. - Kreeka teeb läbi pankroti ja kõik on rahul / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2011-01-01

Euroala liidrite tippkohtumisel otsustati pikendada Kreekale tulevikus antavate EFSF-laenude tähtaegu, samuti lubati alandada Kreekale antavate laenude intresse ja pikendada ka juba 2010. a. kokkulepitud abiprogrammist saadavate laenude tähtaegu. Rahaturud reageerisid tippkohtumisel saavutatud kokkuleppele üllatavalt positiivselt. Eestit esindas kohtumisel president Toomas Hendrik Ilves. Rahandusminister Jürgen Ligi kommentaare

BELIEFS AND PRACTICES OF QASHQAI TURKS WITHIN THE CIRCLE OF BIRTH KAŞKAY TÜRKLERİNDE DOĞUM ÇEVRESİNDE GELİŞEN İNANÇ VE PRATİKLER

Directory of Open Access Journals (Sweden)

Mehmet KARAASLAN

2011-09-01

Full Text Available In this study, which deals with the birth traditions of The Qashqai, and beliefs and practices in this aspect, the data gained through approximately two-month studies in the field of Iran are used. During the field of study, based on the use of techniques such as participated observation and question and answer, Qashqai people, both have urban live and haven’t plucked their ties with nomadism in appropriately with their current social tissues, have been discussed with. These rituals and beliefs formed within the frame of birth are examined through the perspectives such as their functions, whether they have an equivalent in the ancient Turkish culture or not and their comparison of aspects similar to the other communities of the world of the Turks. Kaşkayların doğum gelenekleri ve bu çerçevedeki inanç ve pratiklerinin ele alındığı bu çalışmada İran sahasında yaklaşık iki ay süresince yapılmış olan saha çalışmasında elde edilen veriler kullanılmıştır. Katılımlı gözlem ve soru cevap gibi tekniklerin kullanılması sureti ile yapılan saha çalışması sırasında Kaşkayların şu anki sosyal dokusuna uygun olarak hem uzun süredir şehir hayatı yaşayan hem göçerlikle bağlantılarını tam olarak koparmamış Kaşkaylarla görüşülmüştür. Doğum çevresinde teşekkül etmiş bu ritüel ve inançlar; işlevleri, kadim Türk kültüründe bir karşılıklarının olup olmadığı ve Türk dünyasının diğer toplulukları ile benzeyen yönlerinin mukayesesi gibi bakış açılarıyla irdelenmiştir.

AMPK activation: a therapeutic target for type 2 diabetes?

OpenAIRE

Saha, Asish; Coughlan,Kimberly; Valentine,Rudy; Ruderman,Neil

2014-01-01

Kimberly A Coughlan, Rudy J Valentine, Neil B Ruderman, Asish K Saha Endocrinology and Diabetes, Department of Medicine, Boston University Medical Center, Boston, MA, USA Abstract: Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance, β-cell dysfunction, and elevated hepatic glucose output. Over 350 million people worldwide have T2D, and the International Diabetes Federation projects that this number will increase to nearly 600 million by 2035. There is a...

String-math 2012

CERN Document Server

Katz, Sheldon; Klemm, Albrecht; Morrison, David R

2015-01-01

This volume contains the proceedings of the conference String-Math 2012, which was held July 16-21, 2012, at the Hausdorff Center for Mathematics, Universitat Bonn. This was the second in a series of annual large meetings devoted to the interface of mathematics and string theory. These meetings have rapidly become the flagship conferences in the field. Topics include super Riemann surfaces and their super moduli, generalized moonshine and K3 surfaces, the latest developments in supersymmetric and topological field theory, localization techniques, applications to knot theory, and many more. The contributors include many leaders in the field, such as Sergio Cecotti, Matthias Gaberdiel, Rahul Pandharipande, Albert Schwarz, Anne Taormina, Johannes Walcher, Katrin Wendland, and Edward Witten. This book will be essential reading for researchers and students in this area and for all mathematicians and string theorists who want to update themselves on developments in the math-string interface.

Kinome expression profiling of human neuroblastoma tumors identifies potential drug targets for ultra high-risk patients.

Science.gov (United States)

Russo, Roberta; Cimmino, Flora; Pezone, Lucia; Manna, Francesco; Avitabile, Marianna; Langella, Concetta; Koster, Jan; Casale, Fiorina; Raia, Maddalena; Viola, Giampietro; Fischer, Matthias; Iolascon, Achille; Capasso, Mario

2017-10-01

Neuroblastoma (NBL) accounts for >7% of malignancies in patients younger than 15 years. Low- and intermediate-risk patients exhibit excellent or good prognosis after treatment, whereas for high-risk (HR) patients, the estimated 5-year survival rates is still <40%. The ability to stratify HR patients that will not respond to standard treatment strategies is critical for informed treatment decisions. In this study, we have generated a specific kinome gene signature, named Kinome-27, which is able to identify a subset of HR-NBL tumors, named ultra-HR NBL, with highly aggressive clinical behavior that not adequately respond to standard treatments. We have demonstrated that NBL cell lines expressing the same kinome signature of ultra-HR tumors (ultra-HR-like cell lines) may be selectively targeted by the use of two drugs [suberoylanilide hydroxamic acid (SAHA) and Radicicol], and that the synergic combination of these drugs is able to block the ultra-HR-like cells in G2/M phase of cell cycle. The use of our signature in clinical practice will allow identifying patients with negative outcome, which would benefit from new and more personalized treatments. Preclinical in vivo studies are needed to consolidate the SAHA and Radicicol treatment in ultra-HR NBL patients. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer

Directory of Open Access Journals (Sweden)

Nelson S. Yee

2012-02-01

Histone deacetylases (HDACs and RNA polymerase III (POLR3 play vital roles in fundamental cellular processes, and deregulation of these enzymes has been implicated in malignant transformation. Hdacs and Polr3 are required for exocrine pancreatic epithelial proliferation during morphogenesis in zebrafish. We aim to test the hypothesis that Hdacs and Polr3 cooperatively control exocrine pancreatic growth, and combined inhibition of HDACs and POLR3 produces enhanced growth suppression in pancreatic cancer. In zebrafish larvae, combination of a Hdac inhibitor (Trichostatin A and an inhibitor of Polr3 (ML-60218 synergistically prohibited the expansion of exocrine pancreas. In human pancreatic adenocarcinoma cells, combination of the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA and ML-60218 produced augmented suppression of colony formation and proliferation, and induction of cell cycle arrest and apoptotic cell death. The enhanced cytotoxicity was associated with supra-additive upregulation of the pro-apoptotic regulator BAX and the cyclin-dependent kinase inhibitor p21CDKN1A. tRNAs have been shown to have pro-proliferative and anti-apoptotic roles, and SAHA-stimulated expression of tRNAs was reversed by ML-60218. These findings demonstrate that chemically targeting developmental regulators of exocrine pancreas can be translated into an approach with potential impact on therapeutic response in pancreatic cancer, and suggest that counteracting the pro-malignant side effect of HDAC inhibitors can enhance their anti-tumor activity.

Reolysin and Histone Deacetylase Inhibition in the Treatment of Head and Neck Squamous Cell Carcinoma

Directory of Open Access Journals (Sweden)

Alena C. Jaime-Ramirez

2017-06-01

Full Text Available Oncolytic viruses (OVs are emerging as powerful anti-cancer agents and are currently being tested for their safety and efficacy in patients. Reovirus (Reolysin, a naturally occurring non-pathogenic, double-stranded RNA virus, has natural oncolytic activity and is being tested in phase I–III clinical trials in a variety of tumor types. With its recent US Food and Drug Administration (FDA orphan drug designation for several tumor types, Reolysin is a potential therapeutic agent for various cancers, including head and neck squamous cell carcinomas (HNSCCs, which have a 5-year survival of ∼55%. Histone deacetylase inhibitors (HDACis comprise a structurally diverse class of compounds with targeted anti-cancer effects. The first FDA-approved HDACi, vorinostat (suberoylanilide hydroxamic acid [SAHA], is currently being tested in patients with head and neck cancer. Recent findings indicate that HDAC inhibition in myeloma cells results in the upregulation of the Reolysin entry receptor, junctional adhesion molecule 1 (JAM-1, facilitating reovirus infection and tumor cell killing both in vitro and in vivo. In this study, we tested the anti-tumor efficacy of HDAC inhibitors AR-42 or SAHA in conjunction with Reolysin in HNSCCs. While HDAC inhibition increased JAM-1 and reovirus entry, the impact of this combination therapy was tested on the development of anti-tumor immune responses.

Education for a Sustainable Future: Strategies of the New Hindu Religious Movements

Directory of Open Access Journals (Sweden)

Martin Haigh

2010-11-01

Full Text Available Increasingly, sustainability is conceived as a crisis of the human mind and the key challenge for pro-sustainability education is developing sufficient motivation in learners. The spiritual aspirations of religious communities contain sufficient motivational force, which may be deployed for effective sustainability education. This paper explores the approaches to sustainability and sustainability education of some internationally-oriented Hindu religious movements. These include the rural education initiatives of Gandhian Sarvodaya, which emphasizes non-harming, self-reliance and personal ethics, ISKCON, which emphasizes devotional service, P.R. Sarkar’s Ananda Marg, which emphasizes cooperative enterprise, the Tantric body re-imagined at the social scale, and Swami Vivekananda’s Sri Ramakrishna Order, which emphasizes karma yoga, spiritual development through service to the God in each human. It also describes the British Hindu contribution to the UNDP/ARC’s multi-faith sustainability initiative “Many Heavens, One Earth”; which is the “Bhumi Project” and its two main campaigns, Green Temples and Compassionate Living.

Determination of dynamic metal complexes and their diffusion coefficients in the presence of different humic substances by combining two analytical techniques.

Digital Repository Service at National Institute of Oceanography (India)

Chakraborty, P.; Manek, A.; Niyogi, S.; Hudson, J.

Niyogi2, Jeff Hudson2 *1National Institute of Oceanography (CSIR), India, Dona Paula, Goa, 403004, India. Phone-91-832-2450495; Fax: 91-832-2450609; E-mail: pchak@nio.org 2 Department of Biology, University of Saskatchewan, Saskatoon, Saskatchewan.... Materials and methods Humic substances: Four different types of humic substances were used in this study. These include soil humic acid from Sigma Aldrich now denoted: SAHA. The well characterized Nordic aquatic humic acid (Catalogue No. 1R105H) (NAHA...

Comparison of the Finnish and German Forest Industry: Computerized Performance Analysis Based on Public Communication and Optimized Neural Network Tool (SOM), Suomen ja Saksan metsäteollisuuden vertailu: Tietokonepohjainen suoritusanalyysi yrityksen viestinnän ja optimoidun neuroverkkomallin avulla

OpenAIRE

Kordelin, Toni Juha

2016-01-01

Tietokoneiden ja tietotekniikan merkitys on kasvanut merkittävästi Internetin yleistymisen myötä. Se on vaikuttanut olennaisesti kommunikointiin ja liiketoiminnan harjoittamiseen. Tätä teknologia ei kuitenkaan pitäisi rajoittaa myynti- ja ostotoimintaan, vaan hyödyntää myös tutkimus- ja liiketoimintatyökaluna ja laajana tietolähteenä. Tässä tutkimuksessa verrataan Suomen sekä Saksan saha- ja paperiteollisuuden suorituskykyä julkisen viestinnän avulla. Metsäsektorilla on perinteisesti ollut...

Major Meelis Kiili jääb koduõuele toodud sõjaga rahule / Meelis Kiili ; interv. Gerli Romanovitsh

Index Scriptorium Estoniae

Kiili, Meelis, 1965-

2004-01-01

Ilmunud ka: Severnoje Poberezhje : Subbota, 22. mai 2004, lk. 5. Suurõppuse "Kevadtorm 2004" staabiülem annab hinnangud õppusele, kommenteerib Eesti liitumist NATO-ga ja sõjafilmide vastavust tegelikkusele

Siseminister Margus Leivo külastas Valgat ja jäi nähtuga rahule / Üllas Linder

Index Scriptorium Estoniae

Linder, Üllas, 1953-

2004-01-01

Visiidil Valgamaale kohtus siseminister omavalitsusjuhtidega, maavalitsuse töötajatega, külastas piirivalvekordonit ja piiripunkte, käis kodakondsus- ja migratsiooniameti Valga büroos, politseijaoskonnas ja päästeteenistuses

Emerging role of brain metastases in the prognosis of breast cancer patients

Directory of Open Access Journals (Sweden)

Hambrecht A

2011-08-01

Full Text Available Amanda Hambrecht1,2, Rahul Jandial2, Josh Neman21Department of Biology, University of Southern California; 2Department of Neurosurgery, Beckman Research Institute, City of Hope National Cancer Center, CA, USAAbstract: Cancer starts with one rogue cell. Through mutations and genomic alterations, the cell acquires specific and stem cell-like characteristics necessary for invasion of a distant organ and ultimately metastasis. Metastatic brain cancer is a particularly formidable disease because of its poor prognosis and the highly resistant nature of the tumor to chemotherapy. Although several types of primary tumors have a tendency to metastasize to the brain, the incidence of brain metastases has increased dramatically in some subsets of breast cancer patients. Several conventional treatments are available, but success is limited and often short-lived. Given that no standard treatment options exist, there is a significant need to investigate the biology of these clinically recalcitrant tumors. Keywords: metastasis, breast cancer, blood-brain barrier, epithelial-mesenchymal transition, mesenchymal-epithelial transition

Çelik Bir Bacanın Dinamik Davranışının Analizi

OpenAIRE

GÜRSOY, Gökhan; YERLİ, Hüseyin R.; KAÇIN, Selçuk

2015-01-01

Giderek artan endüstriyel tesislerin (termik ve nükleer santraller, demir çelik fabrikaları, değişik imalata yönelik fabrikalar) ihtiyacı olan endüstriyel bacalar için ülkemizde henüz bir standart bulunmamaktadır. Yine bu yapıların modellenmesi için paket programlar kullanılmakta ancak gerçek davranışı hakkında saha çalışmalarına gerek duyulmaktadır

Calculation of thermodynamic functions of aluminum plasma for high-energy-density systems

International Nuclear Information System (INIS)

Shumaev, V. V.

2016-01-01

The results of calculating the degree of ionization, the pressure, and the specific internal energy of aluminum plasma in a wide temperature range are presented. The TERMAG computational code based on the Thomas–Fermi model was used at temperatures T > 105 K, and the ionization equilibrium model (Saha model) was applied at lower temperatures. Quantitatively similar results were obtained in the temperature range where both models are applicable. This suggests that the obtained data may be joined to produce a wide-range equation of state.

Secondary ion emission

International Nuclear Information System (INIS)

Krohn, V.E.

1976-01-01

The Saha-Langmuir equation that describes the equilibrium emission process, surface ionization, has also been used to describe ion yields observed in the non-equilibrium emission process, sputtering. In describing sputtering, it is probably best to include the potential due to an image charge in the expression for negative as well as positive ion yield and to treat the work function and the temperature as parameters having limited physical significance. Arguments are presented to suggest that sputtered material is not emitted from a plasma. (Auth.)

Ionization of anisothermal plasmas

International Nuclear Information System (INIS)

Dennery, F.M.

1994-01-01

During this last mid-century, only the temperature of electrons has been involved in the Saha's mass action law, whatever be the other ionic and neutral ones in any isothermal or anisothermal plasma. In order to set aside this underlying paradox in the case of argon ionization, it is necessary to improve this equation of partial equilibrium after having defined: - the basic Gibbs-Duhem's relations for such a polythermal mixture, - the inhomogeneous equilibrium issued from chemical reactions according to Le Chatelier's principle. (author). 3 refs

Antitumor Action of a Novel Histone Deacetylase Inhibitor, YF479, in Breast Cancer

Directory of Open Access Journals (Sweden)

Tao Zhang

2014-08-01

Full Text Available Accumulating evidence demonstrates important roles for histone deacetylase in tumorigenesis (HDACs, highlighting them as attractive targets for antitumor drug development. Histone deactylase inhibitors (HDACIs, which have shown favorable anti-tumor activity with low toxicity in clinical investigations, are a promising class of anticancer therapeutics. Here, we screened our compound library to explore small molecules that possess anti-HDAC activity and identified a novel HDACI, YF479. Suberoylanilide hydroxamic acid (SAHA, which was the first approved HDAC inhibitor for clinical treatment by the FDA, was as positive control in our experiments. We further demonstrated YF479 abated cell viability, suppressed colony formation and tumor cell motility in vitro. To investigate YF479 with superior pharmacodynamic properties, we developed spontaneous and experimental breast cancer animal models. Our results showed YF479 significantly inhibited breast tumor growth and metastasis in vivo. Further study indicated YF479 suppressed both early and end stages of metastatic progression. Subsequent adjuvant chemotherapy animal experiment revealed the elimination of local-regional recurrence (LRR and distant metastasis by YF479. More important, YF479 remarkably prolonged the survival of tumor-bearing mice. Intriguingly, YF479 displayed more potent anti-tumor activity in vitro and in vivo compared with SAHA. Together, our results suggest that YF479, a novel HDACI, inhibits breast tumor growth, metastasis and recurrence. In light of these results, YF479 may be an effective therapeutic option in clinical trials for patients burdened by breast cancer.

Pressure of a partially ionized hydrogen gas: numerical results from exact low temperature expansions

Energy Technology Data Exchange (ETDEWEB)

Alastuey, A. [Laboratoire de Physique, ENS Lyon, CNRS, Lyon (France); Ballenegger, V. [Institut UTINAM, Universite de Franche-Comte, CNRS, Besancon (France)

2010-01-15

We consider a partially ionized hydrogen gas at low densities, where it reduces almost to an ideal mixture made with hydrogen atoms in their ground-state, ionized protons and ionized electrons. By performing systematic low-temperature expansions within the physical picture, in which the system is described as a quantum electron-proton plasma interacting via the Coulomb potential, exact formulae for the first.ve leading corrections to the ideal Saha equation of state have been derived[A. Alastuey, V. Ballenegger et al., J. Stat. Phys. 130, 1119 (2008)]. Those corrections account for all effects of interactions and thermal excitations up to order exp(E{sub H} /kT) included, where E{sub H} {approx_equal} -13.6 eV is the ground state energy of the hydrogen atom. Among the.ve leading corrections, three are easy to evaluate, while the remaining ones involve suitably truncated internal partition functions of H{sub 2} molecules and H{sup -} and H{sub 2}{sup +} ions, for which no analytical formulae are available in closed form. We estimate those partitions functions at.nite temperature via a simple phenomenology based on known values of rotational and vibrational energies. This allows us to compute numerically the leading deviations to the Saha pressure along several isotherms and isochores. Our values are compared with those of the OPAL tables (for pure hydrogen) calculated within the ACTEX method (copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

EFFICACY OF INTR A ARTICULAR INJECTIONS OF GENTAMYCIN IN GOUT ARTHRITIS

Directory of Open Access Journals (Sweden)

R N Protopopova

2000-01-01

Full Text Available Summary» Aim: To study the incidence ofjoints complaints aimed at determining group for further clinical examination. Material and methods: Simultaneous continuous epidemiological study among residents of four typical rural settlements in the Republic of Saha (Yakutia with scanning questionaire was used. Results: At the result of questionaire of570 persons with joint pains and 735 with spinal pains were found which amounted to 46.9% and 60.4% of examined population correspondingly. Conclusion: Joint and spinal complains are frequent manifestations with increasing distribation in older aged groups.

A statistical mechanical model for equilibrium ionization

International Nuclear Information System (INIS)

Macris, N.; Martin, P.A.; Pule, J.

1990-01-01

A quantum electron interacts with a classical gas of hard spheres and is in thermal equilibrium with it. The interaction is attractive and the electron can form a bound state with the classical particles. It is rigorously shown that in a well defined low density and low temperature limit, the ionization probability for the electron tends to the value predicted by the Saha formula for thermal ionization. In this regime, the electron is found to be in a statistical mixture of a bound and a free state. (orig.)

Role of low level flow on the summer monsoon rainfall over the Indian subcontinent during two contrasting monsoon years

Digital Repository Service at National Institute of Oceanography (India)

Swapna, P.; RameshKumar, M.R.

northern summer, Quad. J. Roy. Met. Soc., 95, 362-380. Findlater, J., 1971. Mean monthly airflow at low levels over the western Indian Ocean, Geophysical memories, No. l15, HMSO, London 53pp. Ghosh, S.K., Pant, M.C. & Dewan, B.N., 1978. Influence...., Kisder, R., Collins, W, Deaven, D, Gandin, m., Saha, S., White, G, Woollen, J, Zhu, Y, Chelliah, M., Ebisuzaki, W, Higgins, W, Janowiak, J., Mo, K. C.,Ropelewski,C.,Wang,J.,Leetma, A., Reynolds, R., Roy Jenne & Dennis Joseph, 1996. The NCEP/NCAR 40...

Ionization of anisothermal plasmas. Ionisation des plasmas polythermes

Energy Technology Data Exchange (ETDEWEB)

Dennery, F.M.

1994-01-01

During this last mid-century, only the temperature of electrons has been involved in the Saha's mass action law, whatever be the other ionic and neutral ones in any isothermal or anisothermal plasma. In order to set aside this underlying paradox in the case of argon ionization, it is necessary to improve this equation of partial equilibrium after having defined: - the basic Gibbs-Duhem's relations for such a polythermal mixture, - the inhomogeneous equilibrium issued from chemical reactions according to Le Chatelier's principle. (author). 3 refs.

A critical review of predictive models for the onset of significant void in forced-convection subcooled boiling

International Nuclear Information System (INIS)

Dorra, H.; Lee, S.C.; Bankoff, S.G.

1993-06-01

This predictive models for the onset of significant void (OSV) in forced-convection subcooled boiling are reviewed and compared with extensive data. Three analytical models and seven empirical correlations are considered in this review. These models and correlations are put onto a common basis and are compared, again on a common basis, with a variety of data. The evaluation of their range of validity and applicability under various operating conditions are discussed. The results show that the correlations of Saha-Zuber seems to be the best model to predict OSV in vertical subcooled boiling flow

Effects of a tattoo on men's behavior and attitudes towards women: An experimental field study.

Science.gov (United States)

Guéguen, Nicolas

2013-11-01

Previous studies have indicated negative evaluations of women with tattoos. However, a study by Swami and Furnham (2007) showed that tattooed women were rated as less physically attractive but more sexually promiscuous. Given that men interpret women's sexual intent according to their physical appearance, we predicted that women with tattoos would be more favorably approached by men. A temporary tattoo was placed on confederates' lower back, or not, and all confederates were instructed to read a book while lying flat on their stomach on a well-known beach. Two experiments were conducted. The first experiment showed that more men (N = 220) approached the tattooed confederates and that the mean latency of their approach was quicker. A second experiment showed that men (N = 440) estimated to have more chances to have a date and to have sex on the first date with tattooed confederates. However, the level of physical attractiveness attributed to the confederate was not influenced by the tattoo condition. These results were discussed with respect to men's possible misinterpretation of women wearing tattoos and the risks associated with this misinterpretation.

Influence of partial ionization and scattering states on the solar interior structure

International Nuclear Information System (INIS)

Ulrich, R.K.

1982-01-01

The equation of state for the solar interior is normally assumed to be a fully ionized gas corrected by the Debye-Hueckel Coulomb interaction, partial degeneracy, and radiation pressure. The assumption of full ionization is dropped in this paper, and the influence of scattering states is included. The theory of scattering states appears to be new to astrophysics. This theory has been developed by Larkin and is discussed thoroughly by Ebeling, Kraft, and Kremp. The effect of scattering states eliminates the need to invoke a process of ''pressure ionization'' for which no satisfactory theory exists. Six solar models which include varying forms of the equation of state are discussed. The Saha equation without scattering states gives a neutrino counting rate of 7.41 SNU for the 37 Cl experiment, while assumed ionization for T>3 x 10 5 K gives 8.87 SNU, and the Saha equation with the lowest order effect of scattering states (Planck-Larkin equation) gives 8.83 SNU. Inclusion of the second virial coefficient due to scattering states brings the result to 9.02 SNU. The changes of quantities such as central temperature and the temperature at the base of the convective envelope are small and bear a similar relationship among the models. The initial hydrogen abundance of the model including the second virial coefficient due to scattering states is in good agreement with that found for the Orion nebula and B stars, i.e., log (N/sub He//N/sub H/)+12 = 10.97

Underling modification in ion beam induced Si wafers

International Nuclear Information System (INIS)

Hazra, S.; Chini, T.K.; Sanyal, M.K.; Grenzer, J.; Pietsch, U.

2005-01-01

Subsurface (amorphous-crystalline interface) structure of keV ion beam modified Si(001) wafers was studied for the first time using non-destructive technique and compared with that of the top one. Ion-beam modifications of the Si samples were done using state-of-art high-current ion implanter facility at Saha Institute of Nuclear Physics by changing energy, dose and angle of incidence of the Ar + ion beam. To bring out the underlying modification depth-resolved x-ray grazing incidence diffraction has been carried out using synchrotron radiation facility, while the structure of the top surface was studied through atomic force microscopy

The thermodynamics of a strictly non-ideal Coulomb system

International Nuclear Information System (INIS)

Krikorian V, R.

1982-01-01

Using the equation of state for a symmetric quantum Coulomb system with strong interactions, the phase transition and the existence of the plasma state are analyzed. With a reduction potential which includes quantum effects, a generalization of Saha's formula is obtained. The thermodynamics stability of the system is demonstrated analytically. The isotherms for equilibrium ionization are presented and the stability of the system is studied. The electrical conductivity is analyzed in a region of critical values, and the predictions are compared with experimental data for which one observes a quantitative change in the conductivity. (L.C.) [pt

Malignant phyllodes tumor of the breast presenting with hypoglycemia: a case report and literature review

Directory of Open Access Journals (Sweden)

Pacioles T

2014-12-01

Full Text Available Toni Pacioles,1 Rahul Seth,2,3 Cesar Orellana,3 Ivy John,4 Veera Panuganty,3 Ruban Dhaliwal3,5 1Department of Hematology and Oncology, Edwards Comprehensive Cancer Center, Marshall University, Huntington, WV, USA; 2Division of Hematology and Oncology, 3Department of Medicine, 4Department of Pathology, 5Division of Endocrinology, SUNY Upstate Medical University, Syracuse, NY, USA Abstract: Phyllodes tumors are rare fibroepithelial neoplasms that account for less than 1% of all breast tumors and are typically found in middle-aged women. Phyllodes tumors that present with hypoglycemia are even rarer. No one morphologic finding is reliable in predicting the clinical behavior of this tumor. Surgery has been the primary mode of treatment to date. However, the extent of resection and the role of adjuvant radiotherapy or chemotherapy are still controversial. Here, we present a challenging case of malignant phyllodes tumor of the breast associated with hypoglycemia, and review the literature regarding clinical findings, pathologic risk factors for recurrence, and treatment recommendations. Keywords: breast cancer, fibroepithelial neoplasm, neuroendocrine tumor, adjuvant treatment, non-islet cell tumor-induced hypoglycemia

Der Meteorologe : (aus dem Band "V". Tallinn 1998) / Elo Viiding ; aus dem Estnischen von Gisbert Jänicke

Index Scriptorium Estoniae

Viiding, Elo, 1974-

2002-01-01

Sisu : Die Möglichkeit des Meteorologen = Meteoroloogi võimalikkusest ; "Der Meteorologe kam 1990 in die Stadt..." = "Meteoroloog saabus linna aastal 1990..." ; "Was wäre dir "Arbeit" des Meteorologen..." = "Mis oleks meteoroloogi töö..." ; "Und ein Unglück für den Meteorologen ist es auch..." = "Ja Meteoroloogi õnnetus on veel see..." ; Angst vor dem Altwerden des Meteorologen = Hirm Meteoroloogi vanakssaamise ees ; Fest. Geschenk = Pidu. Kink ; "Wenn der Meteorologe eine Grösse sieht, ist er darüber..." = "Kui meteoroloog näeb suurust, on ta selle kohal..." ; Der Meteorologe wird im Saal erwartet = Meteoroloogi oodatakse saali ; "Das Abkommen mit der Meteorologenerwartung kündigen..." = "Katkestada leping meteoroloogiootusega..." ; "Die "Wege des Herrn" sind der Meteorologe..." = "Looja tee" on Meteoroloog..." ; Von dem Fremden, der im Saal den Meteorologen traf = Võõra lugu, kes Meteoroloogi saalis kohtas ; "Den Fremden hervorzuhusten, der von dem..." = "Köhida enesest välja võõras, kes tahtis teha..." ; Der Fremde beruhigt sich nicht = Võõras ei jää rahule

Inhalation drug delivery devices: technology update

Directory of Open Access Journals (Sweden)

Ibrahim M

2015-02-01

Full Text Available Mariam Ibrahim, Rahul Verma, Lucila Garcia-ContrerasDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USAAbstract: The pulmonary route of administration has proven to be effective in local and systemic delivery of miscellaneous drugs and biopharmaceuticals to treat pulmonary and non-pulmonary diseases. A successful pulmonary administration requires a harmonic interaction between the drug formulation, the inhaler device, and the patient. However, the biggest single problem that accounts for the lack of desired effect or adverse outcomes is the incorrect use of the device due to lack of training in how to use the device or how to coordinate actuation and aerosol inhalation. This review summarizes the structural and mechanical features of aerosol delivery devices with respect to mechanisms of aerosol generation, their use with different formulations, and their advantages and limitations. A technological update of the current state-of-the-art designs proposed to overcome current challenges of existing devices is also provided.Keywords: pulmonary delivery, asthma, nebulizers, metered dose inhaler, dry powder inhaler

Viktor Andrejev : "Loodan, et meie üliõpilased on oma valikuga sama rahul kui mina" / Viktor Andrejev ; interv. Niina Voropajeva

Index Scriptorium Estoniae

Andrejev, Viktor, 1948-

2006-01-01

Ilmunud ka: Severnoje Poberezhje : Subbota 29. juuli lk. 3. Endine Riigikogu liige, praegune TTÜ Virumaa kolledzhi direktor vastab küsimustele, mis puudutavad tänavust konkurssi Virumaa kolledzhisse, riikliku tellimuse suurust, kolledzhi juhtimist, endist poliitikukarjääri ning harrastusi. Lisa: CV. Kommenteerib Nikolai Kutashov

On the effect of electron's runaway in partially ionized hydrogen semiclassical nonideal plasma

International Nuclear Information System (INIS)

Turekhanova, K.M.

2011-01-01

Complete text of publication follows. The effect of runaway electrons occurs frequently in tokamak plasmas. The majority of experiments in tokamak research have been devoted to the study of confinement properties of runaway electrons. Runaway electrons are reason of various destroying untolarance in tokamak plasmas. At high plasma density, when the critical energy is comparable with the rest energy the multiplication of runaway electrons accelerate at the sacrifice of increase of plasma density. The plasma conductivity is determined by electrons with energy several times higher than the thermal one and does not practically depend on slower electrons distribution. It is important to analyze the probability of runaway electrons at investigation of physical properties of nonideal plasmas under external electric field and running numerical simulations of their. The present paper is devoted to the investigation of effect of runaway electrons in partially ionized hydrogen dense plasma using the effective potentials of particle's interaction. At the investigation of composition of plasma we used the Saha equation with corrections to nonideality (lowering of ionization potentials). The Saha equation was solved for obtaining of plasma ionization stages at the different number density and temperature. As well, when take into account quantum-mechanical diffraction and screening effects, whereas free path of electrons increases with increase of plasma coupling parameter. The condition for appearance of runaway electrons in semiclassical partially ionized plasma is more favorable in regime of dense plasma. In summary it means that the probability of runaway electron in dense plasma is more than the same in rarified plasma that is possibly connected with formation of some ordered structures in dense plasma.

Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes.

Directory of Open Access Journals (Sweden)

Richard Brad Jones

2014-08-01

Full Text Available Resting memory CD4+ T-cells harboring latent HIV proviruses represent a critical barrier to viral eradication. Histone deacetylase inhibitors (HDACis, such as suberanilohydroxamic acid (SAHA, romidepsin, and panobinostat have been shown to induce HIV expression in these resting cells. Recently, it has been demonstrated that the low levels of viral gene expression induced by a candidate HDACi may be insufficient to cause the death of infected cells by viral cytopathic effects, necessitating their elimination by immune effectors, such as cytotoxic T-lymphocytes (CTL. Here, we study the impact of three HDACis in clinical development on T-cell effector functions. We report two modes of HDACi-induced functional impairment: i the rapid suppression of cytokine production from viable T-cells induced by all three HDACis ii the selective death of activated T-cells occurring at later time-points following transient exposures to romidepsin or, to a lesser extent, panobinostat. As a net result of these factors, HDACis impaired CTL-mediated IFN-γ production, as well as the elimination of HIV-infected or peptide-pulsed target cells, both in liquid culture and in collagen matrices. Romidepsin exerted greater inhibition of antiviral function than SAHA or panobinostat over the dose ranges tested. These data suggest that treatment with HDACis to mobilize the latent reservoir could have unintended negative impacts on the effector functions of CTL. This could influence the effectiveness of HDACi-based eradication strategies, by impairing elimination of infected cells, and is a critical consideration for trials where therapeutic interruptions are being contemplated, given the importance of CTL in containing rebound viremia.

HIGH-TEMPERATURE IONIZATION IN PROTOPLANETARY DISKS

Energy Technology Data Exchange (ETDEWEB)

Desch, Steven J. [School of Earth and Space Exploration, Arizona State University, P.O. Box 871404, Tempe, AZ 85287-1404 (United States); Turner, Neal J. [Jet Propulsion Laboratory, Mail Stop 169-506, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States)

2015-10-01

We calculate the abundances of electrons and ions in the hot (≳500 K), dusty parts of protoplanetary disks, treating for the first time the effects of thermionic and ion emission from the dust grains. High-temperature ionization modeling has involved simply assuming that alkali elements such as potassium occur as gas-phase atoms and are collisionally ionized following the Saha equation. We show that the Saha equation often does not hold, because free charges are produced by thermionic and ion emission and destroyed when they stick to grain surfaces. This means the ionization state depends not on the first ionization potential of the alkali atoms, but rather on the grains’ work functions. The charged species’ abundances typically rise abruptly above about 800 K, with little qualitative dependence on the work function, gas density, or dust-to-gas mass ratio. Applying our results, we find that protoplanetary disks’ dead zone, where high diffusivities stifle magnetorotational turbulence, has its inner edge located where the temperature exceeds a threshold value ≈1000 K. The threshold is set by ambipolar diffusion except at the highest densities, where it is set by Ohmic resistivity. We find that the disk gas can be diffusively loaded onto the stellar magnetosphere at temperatures below a similar threshold. We investigate whether the “short-circuit” instability of current sheets can operate in disks and find that it cannot, or works only in a narrow range of conditions; it appears not to be the chondrule formation mechanism. We also suggest that thermionic emission is important for determining the rate of Ohmic heating in hot Jupiters.

The rights of the medically uninsured: an analysis of social justice and disparate health outcomes.

Science.gov (United States)

Chandler, Michelle

2006-01-01

As technological advances in the United States continue to improve the effectiveness of medical interventions, expectations among Americans of both improved health and extended life expectancy have also increased. At the same time, many of the population continue to lack the insurance necessary to access even the most basic healthcare services (Institute of Medicine, 2004; Tunzi, 2004; Saha & Bindman, 2001). With approximately 18,000 avoidable deaths attributed annually to inadequate medical coverage and 43.6 million individuals currently without insurance benefits, the need to address the disparity in access to treatment and a means of social justice in the distribution of health care is all too clear (Crispen & Whalen, 2004). As a nation relying on market mechanisms to regulate the costs and quality of available health resources (Baldor, 2003; Saha&Bindman, 2001), the welfare of society as a whole may soon be threatened by the provision of marginal services to a select minority as increasing numbers of the uninsured continue to experience less favorable clinical outcomes and higher mortality rates (Tunzi, 2004; Litaker & Cebul, 2003; Jackson, 2001; Sox, Burstin, Edwards, O'Neil et al., 1998). The author will first examine the consequences of being among the growing number of uninsured individuals in the United States. Attention will then be given to exploring the social justice issues inherent in this critical problem and evaluating these issues through the perspective of both libertarian and feminist theory. Using these theories, innovative strategies for attaining distributive justice in the provision of health care will be offered with recommendations for utilizing these alternative approaches to develop and implement future health policy.

Evaluation of electrical conductivity in high-pressure plasmas formed in xenon with sodium as additive

Energy Technology Data Exchange (ETDEWEB)

Novakovic, N V [Faculty of Philosophy, Nis (Yugoslavia); Stojilkovic, S M [Faculty of Electronics, Nis (Yugoslavia); Milic, B S [Dept. of Physics and Meteorology, Faculty of Natural and Mathematical Sciences, Belgrade (Yugoslavia)

1990-02-01

Results of a numerical evaluation of the electrical conductivity in high-pressure plasmas of intermediate degrees of ionization formed in xenon with, respectively, 1% and 10% of sodium are presented, for temperatures between 2000 K and 20 000 K, and for pressures ranging from the normal atmospheric value p{sub atm} = 0.1 MPa up to 2.5 MPa. The equilibrium plasma composition, necessary for the evaluations, was determined on the ground of the Saha equations combined with the charge conservation relation and the assumption that the pressure remained constant in the course of temperature variations. The ionization energy lowering, required in conjunction with the Saha equations, was obtained with the aid of a modified expression for the plasma Debye radius proposed previously. The electron elastic collisions with the charged particles were described by the Spitzer-Haerm (or, rather, Rutherford) formula, and those with the neutrals were taken into account by a polynomial formula interpolating some selected experimental results. The evaluated electrical conductivity is found to increase with the pressure at fixed temperature (except in the mixture with 10% of sodium, in which case an indistinct maximum at p = 10 p{sub atm} can be seen for 6000 K). This feature is opposite to what is found in pure xenon plasma and, except in the upper part of the temperature range analysed, agrees well with the behaviour of pure alkaline vapours. The numerical values obtained for the electrical conductivity are smaller than the figures resulting from the approximate formulae commonly used in numerical estimates of this transport coefficient in moderately non-ideal plasmas of intermediate degrees of ionization, much in accordance with the trends suggested by the experiment. (orig.).

Differential effects of histone deacetylase inhibitors on cellular drug transporters and their implications for using epigenetic modifiers in combination chemotherapy.

Science.gov (United States)

Valdez, Benigno C; Li, Yang; Murray, David; Brammer, Jonathan E; Liu, Yan; Hosing, Chitra; Nieto, Yago; Champlin, Richard E; Andersson, Borje S

2016-09-27

HDAC inhibitors, DNA alkylators and nucleoside analogs are effective components of combination chemotherapy. To determine a possible mechanism of their synergism, we analyzed the effects of HDAC inhibitors on the expression of drug transporters which export DNA alkylators. Exposure of PEER lymphoma T-cells to 15 nM romidepsin (Rom) resulted in 40%-50% reduction in mRNA for the drug transporter MRP1 and up to ~500-fold increase in the MDR1 mRNA within 32-48 hrs. MRP1 protein levels concomitantly decreased while MDR1 increased. Other HDAC inhibitors - panobinostat, belinostat and suberoylanilide hydroxamic acid (SAHA) - had similar effects on these transporters. The protein level of MRP1 correlated with cellular resistance to busulfan and chlorambucil, and Rom exposure sensitized cells to these DNA alkylators. The decrease in MRP1 correlated with decreased cellular drug export activity, and increased level of MDR1 correlated with increased export of daunorubicin. A similar decrease in the level of MRP1 protein, and increase in MDR1, were observed when mononuclear cells derived from patients with T-cell malignancies were exposed to Rom. Decreased MRP1 and increased MDR1 expressions were also observed in blood mononuclear cells from lymphoma patients who received SAHA-containing chemotherapy in a clinical trial. This inhibitory effect of HDAC inhibitors on the expression of MRP1 suggests that their synergism with DNA alkylating agents is partly due to decreased efflux of these alkylators. Our results further imply the possibility of antagonistic effects when HDAC inhibitors are combined with anthracyclines and other MDR1 drug ligands in chemotherapy.

THERMODYNAMIC DEPRESSION OF IONIZATION POTENTIALS IN NONIDEAL PLASMAS: GENERALIZED SELF-CONSISTENCY CRITERION AND A BACKWARD SCHEME FOR DERIVING THE EXCESS FREE ENERGY

International Nuclear Information System (INIS)

Zaghloul, Mofreh R.

2009-01-01

Accurate and consistent prediction of thermodynamic properties is of great importance in high-energy density physics and in modeling stellar atmospheres and interiors as well. Modern descriptions of thermodynamic properties of such nonideal plasma systems are sophisticated and/or full of pitfalls that make it difficult, if not impossible, to reproduce. The use of the Saha equation modified at high densities by incorporating simple expressions for depression of ionization potentials is very convenient in that context. However, as it is commonly known, the incorporation of ad hoc or empirical expressions for the depression of ionization potentials in the Saha equation leads to thermodynamic inconsistencies. The problem of thermodynamic consistency of ionization potentials depression in nonideal plasmas is investigated and a criterion is derived, which shows immediately, whether a particular model for the ionization potential depression is self-consistent, that is, whether it can be directly related to a modification of the free-energy function, or not. A backward scheme is introduced which can be utilized to derive nonideality corrections to the free-energy function from formulas of ionization potentials depression derived from plasma microfields or in ad hoc or empirical fashion provided that the aforementioned self-consistency criterion is satisfied. The value and usefulness of such a backward method are pointed out and discussed. The above-mentioned criterion is applied to investigate the thermodynamic consistency of some historic models in the literature and an optional routine is introduced to recover their thermodynamic consistencies while maintaining the same functional dependence on the species densities as in the original models. Sample computational problems showing the effect of the proposed modifications on the computed plasma composition are worked out and presented.

HIGH-TEMPERATURE IONIZATION IN PROTOPLANETARY DISKS

International Nuclear Information System (INIS)

Desch, Steven J.; Turner, Neal J.

2015-01-01

We calculate the abundances of electrons and ions in the hot (≳500 K), dusty parts of protoplanetary disks, treating for the first time the effects of thermionic and ion emission from the dust grains. High-temperature ionization modeling has involved simply assuming that alkali elements such as potassium occur as gas-phase atoms and are collisionally ionized following the Saha equation. We show that the Saha equation often does not hold, because free charges are produced by thermionic and ion emission and destroyed when they stick to grain surfaces. This means the ionization state depends not on the first ionization potential of the alkali atoms, but rather on the grains’ work functions. The charged species’ abundances typically rise abruptly above about 800 K, with little qualitative dependence on the work function, gas density, or dust-to-gas mass ratio. Applying our results, we find that protoplanetary disks’ dead zone, where high diffusivities stifle magnetorotational turbulence, has its inner edge located where the temperature exceeds a threshold value ≈1000 K. The threshold is set by ambipolar diffusion except at the highest densities, where it is set by Ohmic resistivity. We find that the disk gas can be diffusively loaded onto the stellar magnetosphere at temperatures below a similar threshold. We investigate whether the “short-circuit” instability of current sheets can operate in disks and find that it cannot, or works only in a narrow range of conditions; it appears not to be the chondrule formation mechanism. We also suggest that thermionic emission is important for determining the rate of Ohmic heating in hot Jupiters

Evaluation of 6-([18F] fluoroacetamido)-1-hexanoic-anilide (18F-FAHA) as imaging probe in tumor xenograft mice model

Science.gov (United States)

Li, Fiona; Cho, Sung Ju; Yu, Lihai; Hudson, Robert H. E.; Luyt, Leonard G.; Pin, Christopher L.; Kovacs, Michael S.; Koropatnick, James; Lee, Ting-Yim

2016-03-01

Alteration in genetic expression is as important as gene mutation in cancer development and proliferation. Epigenetic changes affect gene expression without altering the DNA sequence. Histone deacetylase (HDAC), an enzyme facilitating histone remodelling, can lead to silencing of tumor suppressor genes making HDAC inhibitors viable anticancer drugs against tumors with increased activity of the enzyme. In this study we evaluated 18F-fluroacetamido-1-hexanoicanilide (18F-FAHA), an artificial HDAC substrate, as imaging probe of HDAC activity of human tumor xenografts in immunocompromised host mice. Human breast and melanoma cell lines, MDA-MB-468 and MDA-MB-435 respectively, known to overexpress HDAC activity were xenografted into immunocompromised mice and HDAC activity was imaged using 18F-FAHA. The melanoma group was treated with saline, SAHA (suberoylanilide hydroxamic acid, an approved anticancer HDAC inhibitor) in DMSO, or DMSO as positive control. Tracer kinetic modelling and SUV were used to estimate HDAC activity from dynamic PET data. Both breast tumor and melanoma group showed great variability in binding rate constant (BRC) of 18F-FAHA suggesting highly variable inter- and intra-tumoral HDAC activity. For the SAHA treated melanoma group, HDAC activity, as monitored by BRC of 18F-FAHA, decreased more than the two (positive and negative) control groups but not tumor growth. Our preliminary study showed that noninvasive PET imaging with 18F-FAHA has the potential to identify patients for whom treatment with HDAC inhibitors are appropriate, to assess the effectiveness of that treatment as an early marker of target reduction, and also eliminate the need for invasive tissue biopsy to individualize treatment.

Blackbody Emission from Laser Breakdown in High-Pressure Gases

Science.gov (United States)

Bataller, A.; Plateau, G. R.; Kappus, B.; Putterman, S.

2014-08-01

Laser induced breakdown of pressurized gases is used to generate plasmas under conditions where the atomic density and temperature are similar to those found in sonoluminescing bubbles. Calibrated streak spectroscopy reveals that a blackbody persists well after the exciting femtosecond laser pulse has turned off. Deviation from Saha's equation of state and an accompanying large reduction in ionization potential are observed at unexpectedly low atomic densities—in parallel with sonoluminescence. In laser breakdown, energy input proceeds via excitation of electrons whereas in sonoluminescence it is initiated via the atoms. The similar responses indicate that these systems are revealing the thermodynamics and transport of a strongly coupled plasma.

Determination numbers of ionized atoms from emission and absorption lines

International Nuclear Information System (INIS)

Alizadeh Azimi, A.; Shokouhi, N.

2002-01-01

Saha, M., (1920) estimated that salter chromosphere is not only due to radiation from neutral atoms, but from ionized atoms. The failure to observe these stellar lines in the laboratory was attributed to internal temperature and pressure about 10* E + 6 K 10* E-7 atm. In this research we found that emission lines of ionized atoms (like Cs) could be measured in laboratory condition, (about 10* E-3 atm and 2000 K) by using Graphite France Atomic Absorption with injection 124 u g C sel. We calculated the numbers of ionized atoms from Bottzman law. We also measured these numbers from area under the energy-time curve

Calculation of opacities and emissivities for carbon plasmas under NLTE and LTE conditions

International Nuclear Information System (INIS)

Gil, J.M.; Rodriguez, R.; Florido, R.; Rubiano, J.G.; Martel, P.; Sauvan, P.; Minguez, E.

2006-01-01

We calculate different optical properties for carbon plasma in a wide range of temperatures and densities by using ATOM3R-OP code which has been recently developed. In this code we have implemented the rate equations, the Saha equation (for local thermodynamic equilibrium) and the coronal equilibrium model. We have calculated average ionizations, level populations, opacities and emissivities and we focus our study on the identification with our code of coronal equilibrium, non-local thermodynamic equilibrium and local thermodynamic equilibrium regions for this kind of plasma. Moreover, we analyse the differences in the optical properties when they are calculated in non-local thermodynamic equilibrium and local thermodynamic equilibrium. (authors)

Some aspects of plasma thermodynamics

International Nuclear Information System (INIS)

Gorgoraki, V.I.

1986-01-01

The objective reasons which have inhibited the development of a plasma-thermodynamics theory are discussed and the authors formulate the fundamental principles which can be the basis of a common plasma-thermodynamics theory. Two kinds of thermodynamic equilibrium plasmas are discussed, an isothermal plasma and a nonisothermal plasma. An isothermal plasma is a high-temperature plasma; the Saha-Eggert equation describes its behavior. A nonisothermal plasma is a low-temperature plasma, and the reactions taking place therein are purely plasma-chemical. The ionization equilibrium and the composition of such a plasma can be found with the aid of the equations presented in this paper

Calculation of opacities and emissivities for carbon plasmas under NLTE and LTE conditions

Energy Technology Data Exchange (ETDEWEB)

Gil, J.M.; Rodriguez, R.; Florido, R.; Rubiano, J.G.; Martel, P. [Las Palmas de Gran Canaria Univ., Dept. de Fisica (Spain); Sauvan, P. [Universidad Nacional de Educacion a Distancia, Dept. de Ingenieria Energetica, Madrid (Spain); Minguez, E. [Madrid Univ. Politecnica, Instituto de Fusion Nuclear-DENIM (Spain)

2006-06-15

We calculate different optical properties for carbon plasma in a wide range of temperatures and densities by using ATOM3R-OP code which has been recently developed. In this code we have implemented the rate equations, the Saha equation (for local thermodynamic equilibrium) and the coronal equilibrium model. We have calculated average ionizations, level populations, opacities and emissivities and we focus our study on the identification with our code of coronal equilibrium, non-local thermodynamic equilibrium and local thermodynamic equilibrium regions for this kind of plasma. Moreover, we analyse the differences in the optical properties when they are calculated in non-local thermodynamic equilibrium and local thermodynamic equilibrium. (authors)

Practical Improvements to the Lee-More Conductivity Near the Metal-Insulator Transition

International Nuclear Information System (INIS)

Desjarlais, Michael P.

2000-01-01

The wide-range conductivity model of Lee and More is modified to allow better agreement with recent experimental data and theories for dense plasmas in the metal-insulator transition regime. Modifications primarily include a new ionization equilibrium model, consisting of a smooth blend between single ionization Saha (with a pressure ionization correction) and the generic Thomas-Fermi ionization equilibrium, a more accurate treatment of electron-neutral collisions using a polarization potential, and an empirical modification to the minimum allowed collision time. These simple modifications to the Lee-More algorithm permit a more accurate modeling of the physics near the metal-insulator transition, while preserving the generic Lee-More results elsewhere

Practical improvements to the Lee-More conductivity near the metal-insulator transition

International Nuclear Information System (INIS)

Desjarlais, M.P.

2001-01-01

The wide-range conductivity model of Lee and More is modified to allow better agreement with recent experimental data and theories for dense plasmas in the metal-insulator transition regime. Modifications primarily include a new ionization equilibrium model, consisting of a smooth blend between single ionization Saha (with a pressure ionization correction) and the generic Thomas-Fermi ionization equilibrium, a more accurate treatment of electron-neutral collisions using a polarization potential, and an empirical modification to the minimum allowed collision time. These simple modifications to the Lee-More algorithm permit a more accurate modeling of the physics near the metal-insulator transition, while preserving the generic Lee-More results elsewhere. (orig.)

Open Praxis, volumen 0 issue 1

Directory of Open Access Journals (Sweden)

Editor Open Praxis

2006-09-01

Full Text Available Table of Contents - Providing Effective Feedback Online Zane Berge & Mauri Collins (1-10 - Mobile Technologies and the Future of Global Education Rory McGreal (11-16 - Cross-Border Higher Education through E-Learning: Issues and Opportunities Kumiko Aoki (17-25 - Open and Distance Education in the Global Environment: Opportunities for Collaboration Ellie Chambers (26-33 - Global Trade in Educational Services: Implications for Open and Distance Learning (ODL S. Savithri & K. Murugan (34-44 - Interactive Computer Simulation to Support Teaching of Biology in Distance Learning Basuki Hardjojo, Diki, S. Nurmawati & Susi Sulistiana (45-54 - An Analysis of Learning Styles of Distance Learners at the Institute of Education Development, Universiti Teknologi Mara, Malaysia Syed Jamal Abdul Nasir bin Syed Mohamad, & Ahmad Saat Daud Mohamad (55-61 - Application of Cognitive Dissonance Theory to Reduce Dropouts in Distance Education System G. Radhakrishna & Anurag Saxena (62-66 - Effects of Globalisation on Education and Culture S. Chinnammai (67-72 - Learning Beyond Boundary: The Quest Of a Global Researcher Gomata Varanasi (73-78 - Computer Technology for Literacy and Empowerment of Masses in Developing Countries Piyush Swami & Sasi Benzigar (79-84

Single-crystal films of a combination of materials (co-crystal) involving DAST and IR-125 for electro-optic applications

Science.gov (United States)

Narayanan, A.; Titus, J.; Rajagopalan, H.; Vippa, P.; Thakur, M.

2006-03-01

Single-crystal film of DAST (4'-dimethylamino-N-methyl-4-stilbazolium tosylate) has been shown [1] to have exceptionally large electro-optic coefficients (r11 ˜ 770 pm/V at 633 nm). In this report, single crystal film of a combination of materials (co-crystal) involving DAST and a dye molecule IR-125 will be discussed. Modified shear method was used to prepare the co-crystal films. The film has been characterized using polarized optical microscopy, optical absorption spectroscopy and x-ray diffraction. The optical absorption spectrum has two major bands: one at about 350--600 nm corresponding to DAST and the other at about 600-900 nm corresponding to IR-125. The x-ray diffraction results show peaks involving the presence of DAST and IR-125 within the co-crystal film. Since the co-crystal has strong absorption at longer wavelengths it is expected to show higher electro-optic coefficients at longer wavelengths. Preliminary measurements at 1.55 μm indicate a high electro-optic coefficient of the co-crystal film. [1] Swamy, Kutty, Titus, Khatavkar, Thakur, Appl. Phys. Lett. 2004, 85, 4025; Kutty, Thakur, Appl. Phys. Lett. 2005, 87, 191111.

Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements

Directory of Open Access Journals (Sweden)

Michael L Levy

2009-01-01

Full Text Available Michael L Levy1, Allen L Ho1,2, Samuel Hughes3, Jayant Menon1, Rahul Jandial41Division of Neurosurgery, University of California, San Diego, La Jolla, California, USA; 2Del E Webb Neurosciences, Aging and Stem Cell Research Center, The Burnham Institute for Medical Research, La Jolla, California, USA; 3Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, USA; 4Division of Neurosurgery, Department of Surgery, City of Hope Cancer Center, Duarte, CA, USAAbstract: The biology of both normal and tumor development clearly possesses overlapping and parallel features. Oncogenes and tumor suppressors are relevant not only in tumor biology, but also in physiological developmental regulators of growth and differentiation. Conversely, genes identified as regulators of developmental biology are relevant to tumor biology. This is particularly relevant in the context of brain tumors, where recent evidence is mounting that the origin of brain tumors, specifically gliomas, may represent dysfunctional developmental neurobiology. Neural stem cells are increasingly being investigated as the cell type that originally undergoes malignant transformation – the cell of origin – and the evidence for this is discussed.Keywords: stem cells, gliomas, neural stem cells, brain tumors, cancer stem cells

[Research on the identification method of LTE condition in the laser-induced plasma].

Science.gov (United States)

Fan, Juan-juan; Huang, Dan; Wang, Xin; Zhang, Lei; Ma, Wei-guang; Dong, Lei; Yin, Wang-bao; Jia, Suo-tang

2014-12-01

Because of the poor accuracy of the commonly used Boltzmann plot method and double-line method, the Boltzmann-Maxwell distribution combined with the Saha-Eggert formula is proposed to improve the measurement accuracy of the plasma temperature; the simple algorithm for determining the linewidth of the emission line was established according to the relationship between the area and the peak value of the Gaussian formula, and the plasma electron density was calculated through the Stark broadening of the spectral lines; the method for identifying the plasma local thermal equilibrium (LTE) condition was established based on the McWhirter criterion. The experimental results show that with the increase in laser energy, the plasma temperature and electron density increase linearly; when the laser energy changes within 127~510 mJ, the plasma electron density changes in the range of 1.30532X10(17)~1.87322X10(17) cm(-3), the plasma temperature changes in the range of 12586~12957 K, and all the plasma generated in this experiment meets the LTE condition threshold according to the McWhirter criterion. For element Al, there exist relatively few observable lines at the same ionization state in the spectral region of the spectrometer, thus it is unable to use the Boltzmann plane method to calculate temperature. One hundred sets of Al plasma spectra were used for temperature measurement by employing the Saha-Boltzmann method and the relative standard deviation (RSD) value is 0.4%, and compared with 1.3% of the double line method, the accuracy has been substantially increased. The methods proposed can be used for rapid plasma temperature and electron density calculation, the LTE condition identification, and are valuable in studies such as free calibration, spectral effectiveness analysis, spectral temperature correction, the best collection location determination, LTE condition distribution in plasma, and so on.

The expanding plasma jet

International Nuclear Information System (INIS)

Sanden, M.C.M. van den.

1991-01-01

This thesis concerns the fundamental aspects of an argon plasma expanding from a cascaded arc. This type of plasma is not only used for fundamental research but also for technologically orientated research on plasma deposition and plasma sources. The important characteristics of the plasma are a strong supersonic expansion in which the neutral particle and ion densities decrease three orders of magnitude, followed by a stationary shock front. After the shock front the plasma expands further subsonically. A part of this thesis is devoted to the discussion of a newly constructed combined Thomson-Rayleigh scattering set up. With this set up the electron density, the electron temperature and the neutral particle density are measured locally in the plasma for different conditions. In the analysis of the measured spectra weak coherent effects and the measured apparatus profile are included. The inaccuracies are small, ranging from 1 to 4 percent for the electron density and 2 to 6 percent for the electron temperature, depending on the plasma conditions. The inaccuracy of the neutral particle density determination is larger and ranges from 10 to 50 percent. The detection limits for the electron and neutral particle density are 7.10 17 m -3 and 1.10 20 m -3 respectively. A side path in this thesis is the derivation of the Saha equation for a two-temperature plasma. The reason for this derivation was the dispute in the literature about the correct form of this equation. In this thesis it is shown, from the correct extension of the second law of thermodynamics and from the non-equilibrium formalism of Zubarev, That in the limit of m e /m h ->0 the generalized Saha equation depends on the electron temperature only. (author). 221 refs.; 54 figs.; 13 tabs

Plasma-related matrix effects in inductively coupled plasma--atomic emission spectrometry by group I and group II matrix-elements

International Nuclear Information System (INIS)

Chan, George C.-Y.; Chan, W.-T.

2003-01-01

The effects of Na, K, Ca and Ba matrices on the plasma excitation conditions in inductively coupled plasma-atomic emission spectrometry (ICP-AES) were studied. Normalized relative intensity was used to indicate the extent of the plasma-related matrix effects. The group I matrices have no effects on the plasma excitation conditions. In contrast, the group II matrices depress the normalized relative intensities of some spectral lines. Specifically, the Group II matrices have no effects on the normalized relative intensity of atomic lines of low upper energy level (soft lines), but reduce the normalized relative intensity of some ionic lines and atomic lines of high energy level (hard lines). The Group II matrices seem to shift the Saha balance of the analytes only; no shift in the Boltzmann balance was observed experimentally. Moreover, for some ionic lines with sum of ionization and excitation potentials close to the ionization potential of argon (15.75 eV), the matrix effect is smaller than other ionic lines of the same element. The reduced matrix effects may be attributed qualitatively to charge transfer excitation mechanism of these ionic lines. Charge transfer reaction renders ionic emission lines from the quasi-resonant levels similar in characteristics of atomic lines. The contribution of charge transfer relative to excitation by other non-specific excitation mechanisms (via Saha balance and Boltzmann balance) determines the degree of atomic behavior of a quasi-resonant level. A significant conclusion of this study is that plasma-related matrix effect depends strongly on the excitation mechanism of a spectral line. Since, in general, more than one excitation mechanism may contribute to the overall excitation of an emission line, the observed matrix effects reflect the sum of the effects due to individual excitation mechanisms. Excitation mechanisms, in addition to the often-used total excitation energy, should be considered in matrix effect studies

Maternal Exposure of Rats to Isoflurane during Late Pregnancy Impairs Spatial Learning and Memory in the Offspring by Up-Regulating the Expression of Histone Deacetylase 2.

Science.gov (United States)

Luo, Foquan; Hu, Yan; Zhao, Weilu; Zuo, Zhiyi; Yu, Qi; Liu, Zhiyi; Lin, Jiamei; Feng, Yunlin; Li, Binda; Wu, Liuqin; Xu, Lin

2016-01-01

Increasing evidence indicates that most general anesthetics can harm developing neurons and induce cognitive dysfunction in a dose- and time-dependent manner. Histone deacetylase 2 (HDAC2) has been implicated in synaptic plasticity and learning and memory. Our previous results showed that maternal exposure to general anesthetics during late pregnancy impaired the offspring's learning and memory, but the role of HDAC2 in it is not known yet. In the present study, pregnant rats were exposed to 1.5% isoflurane in 100% oxygen for 2, 4 or 8 hours or to 100% oxygen only for 8 hours on gestation day 18 (E18). The offspring born to each rat were randomly subdivided into 2 subgroups. Thirty days after birth, the Morris water maze (MWM) was used to assess learning and memory in the offspring. Two hours before each MWM trial, an HDAC inhibitor (SAHA) was given to the offspring in one subgroup, whereas a control solvent was given to those in the other subgroup. The results showed that maternal exposure to isoflurane impaired learning and memory of the offspring, impaired the structure of the hippocampus, increased HDAC2 mRNA and downregulated cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) mRNA, N-methyl-D-aspartate receptor 2 subunit B (NR2B) mRNA and NR2B protein in the hippocampus. These changes were proportional to the duration of the maternal exposure to isoflurane and were reversed by SAHA. These results suggest that exposure to isoflurane during late pregnancy can damage the learning and memory of the offspring rats via the HDAC2-CREB -NR2B pathway. This effect can be reversed by HDAC2 inhibition.

Development of a magnetohydrodynamic code for axisymmetric, high-β plasmas with complex magnetic fields

International Nuclear Information System (INIS)

Cook, G.O. Jr.

1982-12-01

The Topolotron is an axisymmetric, toroidal magnetic fusion concept in which two-dimensional effects are important, as well as all three magnetic field components. The particular MHD model employed is basically the one-fluid, two-temperature model using classical Braginskii transport with viscous effects ignored. The model is augmented by Saha-Boltzmann dissociation and partial ionization physics, a simple radiation loss mechanism, and an additional resistivity due to electron-neutral collisions. While retaining all velocity and magnetic field components, the assumption of axisymmetry is made, and the resulting equations are expanded in cylindrical coordinates. The major approximation technique is then applied: spline collocation, which reduces these equations to a set of ordinary differential equations

Static flow instability in subcooled flow boiling in parallel channels

International Nuclear Information System (INIS)

Siman-Tov, M.; Felde, D.K.; McDuffee, J.L.; Yoder, G.L. Jr.

1995-01-01

A series of tests for static flow instability or flow excursion (FE) at conditions applicable to the proposed Advanced Neutron Source reactor was completed in parallel rectangular channels configuration with light water flowing vertically upward at very high velocities. True critical heat flux experiments under similar conditions were also conducted. The FE data reported in this study considerably extend the velocity range of data presently available worldwide. Out of the three correlations compared, the Saha and Zuber correlation had the best fit with the data. However, a modification was necessary to take into account the demonstrated dependence of the Stanton (St) and Nusselt (Nu) numbers on subcooling levels, especially in the low subcooling regime

Positive body image: inter-ethnic and rural-urban differences among an indigenous sample from Malaysian Borneo.

Science.gov (United States)

Swami, Viren; Kannan, Kumaraswami; Furnham, Adrian

2012-11-01

Previous studies examining body image from a cross-cultural perspective have tended to neglect samples from different ethnic groups or along a rural-urban continuum. To overcome this limitation, the present study examined positive body image among rural and urban women from three major indigenous ethnic groups in Sabah, Malaysia. A total of 202 women completed the Body Appreciation Scale, as well as measures of media exposure and financial security, and provided their demographic details. s showed that there were significant rural-urban differences in body appreciation, with rural participants having significantly higher body appreciation than urban participants. A comparison with a previous data set of West Malaysian women (Swami & Chamorro-Premuzic, 2008) showed that the current urban sample had significantly lower body appreciation and that the rural group had significantly higher body appreciation. Further results showed that research site (urban vs rural) explained 11.0% of the variance in body appreciation. Participant body mass index and exposure to western forms of media explained an additional 2.0% of the variance. These results suggest that there are differences in body image between rural and urban women. Results are discussed in relation to the promotion of positive body image, particularly in developing societies where health care resources may be limited.

Decoding the integrated approach to yoga therapy: Qualitative evidence based conceptual framework.

Science.gov (United States)

Villacres, Maria Del Carmen; Jagannathan, Aarti; Nagarathna, R; Ramakrsihna, Jayashree

2014-01-01

The aim of this study was to define, decode, and append to the conceptual frame-work of the integrated approach to yoga therapy (IAYT). Four stakeholders who followed two in-patients with depression over a period of 2 weeks in the residential center Arogyadhama (of Swami Vivekananda Yoga Anusandana Samsthana, Bangalore, India) were interviewed before the start of the IAYT treatment and prior to discharge of the patient. The patients were also interviewed pre and post and were observed once during their session. The data from the audio recordings from eight in-depth interviews were transcribed manually and qualitative analysis was conducted. The conceptual frame-work of IAYT depicts that patient related factors ("co-operation of patient", "patients awareness of his/her condition"), therapist related factors ("ability to guide", "the assistance to the patients", "explanation of the exercises") and treatment related factors ("combination of psychiatric or Ayurvedic medication with yoga", "counseling during the IAYT treatment", duration of treatment), play an integrated role in reaching the "aim of IAYT" and experiencing "improvements and changes". The IAYT is a holistic program and the ability of the patient to cooperate with and integrate the available factors (therapist related and treatment related) could enable best results.

Opacity and Transport Measurements Reveal That Dilute Plasma Models of Sonoluminescence Are Not Valid

Science.gov (United States)

Khalid, Shahzad; Kappus, Brian; Weninger, Keith; Putterman, Seth

2012-03-01

A strong interaction between a nanosecond laser and a 70 μm radius sonoluminescing plasma is achieved. The overall response of the system results in a factor of 2 increase in temperature as determined by its spectrum. Images of the interaction reveal that light energy is absorbed and trapped in a region smaller than the sonoluminescence emitting region of the bubble for over 100 ns. We interpret this opacity and transport measurement as demonstrating that sonoluminescencing bubbles can be 1000 times more opaque than what follows from the Saha equation of statistical mechanics in the ideal plasma limit. To address this discrepancy, we suggest that the effects of strong Coulomb interactions are an essential component of a first principles theory of sonoluminescence.

Structure optimization and preliminary bioactivity evaluation of N-hydroxybenzamide-based HDAC inhibitors with Y-shaped cap.

Science.gov (United States)

Yu, Chenggong; He, Feng; Qu, Ying; Zhang, Qiuqiong; Lv, Jiahui; Zhang, Xiangna; Xu, Ana; Miao, Pannan; Wu, Jingde

2018-05-01

Histone deacetylase inhibitors (HDACIs) are effective small molecules in the treatment of human cancers. In our continuing efforts to develop novel N-hydroxyterephthalamide-based HDACIs, herein we report the design and development of a new class of N-hydroxybenzamide-based HDACIs. In this new class of analogs, we inserted an ethylene moiety in the linker and used indole as a part of the Y-shaped cap group. Biological characterization identified compounds 4o, 4p, 4q and 4t to show improved HDAC inhibition, while no isoform selectivity for HDACs was observed. These compounds also exhibited improved anti-proliferative activity against multiple cancer cell lines when compared to their parent compound and positive control SAHA. Copyright © 2018 Elsevier Ltd. All rights reserved.

Enflasyon Ortamında Mamul Fiyatlandırması

OpenAIRE

GÜNEŞ, Recep

2013-01-01

Fiyatlandırma konusu farklı bilim dallarında farklı varsayımlaradayandırılarak açıklanmaya çalışılırken, uygulama alanındamaliyet artı metodunun önemli bir yer tuttuğu yapılan saha çalışmalarındaortaya konulmuştur. Maliyet artı kar metodunun genelolarak enflasyonun olmadığı ortamlarda kolayca uygulanabilirken,maliyetlerin sürekli değiştiği enflasyon ortamında fiyatlandırmadaha da karmaşık bir görünüm arz etmektedir. Bu çalışmada,enflasyon ortamında maliyet artı kar metodunun uygulanabilirliği...

High ion charge states in a high-current, short-pulse, vacuum ARC ion sources

International Nuclear Information System (INIS)

Anders, A.; Brown, I.; MacGill, R.; Dickinson, M.

1996-01-01

Ions of the cathode material are formed at vacuum arc cathode spots and extracted by a grid system. The ion charge states (typically 1-4) depend on the cathode material and only little on the discharge current as long as the current is low. Here the authors report on experiments with short pulses (several μs) and high currents (several kA); this regime of operation is thus approaching a more vacuum spark-like regime. Mean ion charge states of up to 6.2 for tungsten and 3.7 for titanium have been measured, with the corresponding maximum charge states of up to 8+ and 6+, respectively. The results are discussed in terms of Saha calculations and freezing of the charge state distribution