WorldWideScience

Sample records for rita estado zulia

  1. Metamorfosis del delito de secuestro en el Estado Zulia, Venezuela

    Directory of Open Access Journals (Sweden)

    María Alejandra Añez Castillo

    2010-12-01

    Full Text Available El delito de secuestro es un flagelo social que ha experimentado mutaciones en el tiempo. El año 2009 terminó con una cifra sin precedentes en cuanto a los secuestros reportados en Venezuela. Los datos aportados por los organismos oficiales revelan que durante el 2008 hubo 537 secuestros, lo cual representa un aumento de 52% respecto al total del 2007, mientras que en el 2009 la cifra se incrementó en un 62,82%, en relación con el año anterior. Esta investigación tiene como objetivo describir el delito de secuestro en Venezuela, con especial referencia al Estado Zulia, población fronteriza limítrofe con Colombia. Para ello se emplea una metodología de tipo documental- descriptiva. Se revela que no existen esquemas predefinidos que permitan caracterizar este tipo penal, pues, tal y como ha venido sucediendo, es susceptible de llevarse a cabo en cualquier momento y circunstancia, no de modo exclusivo en sujetos de alto estatus socioeconómico, sino con mínimos medios para responder a las exigencias de los plagiarios; de aquí la proliferación de la modalidad del llamado secuestro exprés. El delito de secuestro en Venezuela ha cambiado en forma notable sus patrones: de ser un delito predominantemente político, fronterizo y ejecutado por grupos organizados, ha pasado a ser uno de objetivos sobre todo económicos, urbano, y ejecutado con un fin de lucro por la delincuencia común. En verdad, el Estado Zulia sigue repuntando en la lista de los estados con mayor incidencia de este delito en Venezuela, pero no es el principal, pues ha sido desplazado en posicionamiento por otras urbes del país, encabezadas en la actualidad por la ciudad capital de Caracas.

  2. Ciberperiodismo en el estado Zulia: Hacia las nuevas competencias profesionales

    Directory of Open Access Journals (Sweden)

    Carmen Mara Prieto

    2009-05-01

    Full Text Available El objetivo de la investigación se centró en describir el perfil profesional de los periodistas que laboran en los cibermedios del estado Zulia. Para abordar el problema se tomó como punto de partida las experiencias periodsticas vivenciadas en cibermedios zulianos (Faras y Prieto, 2006, 2007; Mogollón y Prieto, 2006 y el perfil del ciberperiodista definido por Albarrán (2008, Aguirre (2006, Saba (2006, Camus (2002 y Gil (1999. Esto implicó describir y caracterizar los equipos de profesionales que integran los cibermedios de la región zuliana en función de aportar a la configuración del perfil del nuevo periodista que pretenda desempeñarse con acierto en el ciberespacio. Desde el punto de vista metodológico, se trató de una investigación descriptiva de carácter cuantitativo con diseño transeccional donde se aplicó como instrumento la encuesta. Entre las conclusiones de la investigación destacan que las competencias ciberperiodsticas en su mayora están instrumentalizadas y asociadas al manejo de editores de texto y datos, as como Internet, siendo estas herramientas suficientes para cubrir las expectativas de sus labores, revelando en este sentido estar muy lejos de los constructos teórico-éticos que deben fundamentar el ciberperiodismo. Predomina en las ciberredacciones del estado Zulia profesionales jóvenes del género masculino egresados en el último lustro, y existe una falta de consenso en las denominaciones de cargos y funciones.

  3. Mercadeo en las Pymes y cooperativas en el estado Zulia

    Directory of Open Access Journals (Sweden)

    María W. Schlesinger

    2005-07-01

    Full Text Available El objetivo del presente trabajo es identificar las fortalezas y las debilidades de la formación en mercadotecnia de los nuevos empresarios en las pequeñas y medianas empresas y cooperativas en el estado Zulia, para la comercialización de bienes y servicios en el ámbito regional. En tal sentido, fue necesario realizar una investigación de tipo descriptivo– transeccional y recopilar información a través de cuestionarios y entrevistas. Se concluyó que los empresarios poseen en su mayoría un conocimiento empírico, y debilidad en el dominio teórico en el área de mercado. Esto genera una subutilización de recursos que se evidencia en la carencia de formalización en la estructura y los procesos organizacionales, así como en el diseño de estrategias de desarrollo y comercialización de los bienes y servicios.

  4. La iglesia católica del estado Zulia y el golpe de estado de 1948

    Directory of Open Access Journals (Sweden)

    Luis Rincón Rubio

    2009-01-01

    Full Text Available Se presenta una aproximación al discurso político-religioso de la jerarquía eclesiástica de la Diócesis del Zulia en relación con el golpe de Estado acaecido en Venezuela el 24 de noviembre de 1948, según las editoriales del diario "La Columna". Se encuentra que la línea editorial de este diario a finales del trienio 1945-1948 demuestra una fuerte oposición de la jerarquía eclesiástica del Zulia al gobierno del trienio acciondemocratista, al cual trató de desprestigiar con la difusión de un discurso negativo acerca de la acción del gobierno en los ámbitos social, moral y educativo, fundamentado en una concepción del partido de gobierno como un brazo del comunismo internacional. Una vez consumado el derrocamiento del presidente Rómulo Gallegos, los editores del diario "La Columna" difunden un discurso legitimador del Golpe de Estado del 24 de Noviembre, asociando al derrocado gobierno con el caos, la inmoralidad, la corrupción y la incapacidad para gobernar, y a las Fuerzas Armadas con el retorno de la moral, con la paz, la seguridad y el bienestar de la familia venezolana.

  5. Marketing estratégico en PYMEs fabricantes de prendas de vestir del estado de Zulia

    OpenAIRE

    Mariher Morales

    2005-01-01

    El objetivo del presente artículo es analizar los componentes del marketing estratégico en las pequeñas y medianas empresas (PYMEs) fabricantes de prendas de vestir del estado Zulia. En el estudio se resalta como fundamento teórico la gestión del marketing sustentado en el proceso de planificación estratégica, cuya finalidad es evaluar el ambiente (interno y externo), definir la misión de la empresa, diseñar sus objetivos, establecer las estrategias a largo plazo y seleccionar los...

  6. Balanced scorecard en las empresas mixtas petroleras del municipio Maracaibo del estado Zulia

    Directory of Open Access Journals (Sweden)

    Alvaro Finali

    2014-01-01

    Full Text Available La presente investigación, tuvo como objetivo identificar las perspectivas basadas en el enfoque del Balanced Scorecard en las empresas mixtas petroleras del municipio Maracaibo del estado Zulia. El sustento teórico utilizado para el estudio, se enmarcó en los aportes realizados por Caycho (2010, Kaplan y Norton, (2004, López (2001, Muñiz y Monfort (2005, Niven (2003, Pérez (2003, Rampersad (2005, Solano et al (2002, entre otros. El presente estudio es de tipo descriptivo, de campo, no experimental, transaccional. La población estuvo conformada en total por cuarenta (40 sujetos entre gerentes y supervisores. Se utilizó como técnica la encuesta, la cual sirvió como mecanismo para evaluar la opinión de la población, a través de un cuestionario estructurado elaborado especialmente para la variable Balanced Scorecard, constituido por cincuenta items, bajo la escala de respuestas tipo Likert, validado por cinco expertos, con un coeficiente Alpha Cronbach que arrojó una confiabilidad de (0,99. Se evidencia cómo en las empresas mixtas petroleras del municipio Maracaibo del estado Zulia, se miden a través de las perspectivas del Balanced Scorecard (BSC algunas veces con el indicador financiera y casi siempre evalúan las del cliente, proceso interno, aprendizaje y crecimiento en la organización, mostrando una tendencia positiva en busca de mejorar su sistema de gestión, para lo cual se recomendó cuidar que todas las perspectivas (financiera, clientes, procesos internos y aprendizaje organizacional, con el fin de que el Sistema Balanceado de Indicadores (SBI produzca la serie de resultados favorables en la administración de la empresas objetos de estudio, ya que para lograrlo es necesario implementar la metodología, monitoreo y análisis constante de los indicadores obtenidos.

  7. Competitividad de la industria de la confección del Municipio Maracaibo – Estado Zulia

    Directory of Open Access Journals (Sweden)

    Mariher Morales

    2002-01-01

    Full Text Available En el presente artículo se analiza el nivel de competitividad de la industria de la confección del municipio Maracaibo del estado Zulia, utilizando como base el instrumental teórico desarrollado por Michael Porter. La investigación es de carácter descriptivo, teniendo como principal fuente de información un estudio de campo. Entre los resultados de la investigación resaltan que la industria de la confección del municipio Maracaibo presenta un bajo nivel competitivo, evidenciando una capacidad ociosa del 50%, un alto grado de atomización e informalidad en su estructura, un bajo nivel tecnológico e insuficiencia de mano de obra especializada, así como una orientación al mercado interno. A esto se agregan dificultades asociadas con el contrabando, problemas con el financiamiento y las materias primas, entre otras. Se sugiere a los empresarios para lograr un posicionamiento en el mercado a largo plazo, desarrollar la estrategia genérica de enfoque de diferenciación con minimización de los costos, esto para aprovechar las características del consumidor maracaibero basadas en el apego a la moda y exigencias de calidad a precios justos.

  8. Estrategias flexibilizadoras aplicadas por las empresas del sector avícola del estado Zulia

    Directory of Open Access Journals (Sweden)

    María Bonomie

    2008-01-01

    Full Text Available El artículo tiene como objetivo, analizar las estrategias flexibilizadoras aplicadas en el proceso productivo por las empresas del sector avícola, específicamente las empresas productoras de pollo del estado Zulia. Para tal fin, se describe el proceso productivo de estas empresas y además se identifican las estrategias aplicadas considerando los acontecimientos económicos influenciados por cambios políticos que en los últimos años han incidido en las empresas productoras de pollo. Se realizó una revisión bibliográfica para determinar los criterios de clasificación de las estrategias, asumiendo la establecida por Gamboa y col. (2001. Se diseñó un instrumento semiestructurado, el cual fue administrado a los gerentes y trabajadores de las empresas analizadas. Los resultados obtenidos reflejan, que las empresas utilizan las estrategias con la finalidad de reestructurar y modernizar sus procesos productivos, mejorar continuamente sus productos e introducir nueva tecnología. Se concluye que estas empresas logran incrementar la productividad, aumentando la cantidad de productos ante la utilización óptima de los recursos humanos y tecnológicos, optimización que implica una reducción de costos de producción para poder expandirse y ofrecer precios competitivos en el mercado.

  9. Estudio seroepidemiologico de la amibiasis en una comunidad del estado Zulia, Venezuela A seroepidemiological study of amebiasis in a community of Zulia State, Venezuela

    Directory of Open Access Journals (Sweden)

    Leonor Chacin-Bonilla

    1990-12-01

    Full Text Available Se realizó un estudio seroepidemiologico de amibiasis en una comunidad de bajas condiciones socioeconómicas del Municipio Mara, Estado Zulia, Venezuela. Se estudiaron 283 individuos cuyas edades fluctuaron de 2 a 53 años. Se obtuvieron muestras de sueros, las cuales se examinaron con la prueba de hemaglutinación indirecta de KESSEL et al., según una modificación de MILGRAM et al. Se utilizó antígeno amibiano obtenido de cultivos axénicos de la raza HK9 de E. histolytica. La tasa de seropositividad obtenida fué de 46.6%; la mayoría de los reactores tenía títulos bajos y no presentaba signos de amibiasis. El porcentaje de seropositividad aumentó con la edad. Los resultados sugieren una alta endemicidad de la infección en esta comunidad, ocurriendo la transmisión con mucha mayor frecuencia que la amibiasis invasiva.In the present evaluation, a community of low socioeconomical conditions from Zulia State, Venezuela, was analyzed for the prevalence of antibodies to E. histolytica. Two hundred and eighty three serum samples were collected and examined by the indirect hemagglutination test according to a microtiter modification of the KESSEL and LEWIS method, as used by MILGRAM et al. Antigen prepared from axenically-grown. E. histolytica strain HK9 in Diamond's medium was used. The seropositivity rate obtained was 46.6% and the frequency of positive cases was dependent on age. The antibody profiles obtained suggest a high endemicity for this parasitic infection in the area studied, with a much higher level of transmission than invasive amebiasis.

  10. Iglesia y participación comunitaria en salud: el caso del Municipio San Francisco del estado Zulia, Venezuela

    OpenAIRE

    José Guillermo García

    2002-01-01

    Este trabajo tiene por objeto identificar en forma comparada los factores que condicionan la participación de las comunidades Betulio González y 24 de Julio del municipio San Francisco del estado Zulia en el subprograma de Medicina Natural que promociona la Iglesia Católica. Bajo un esquema conceptual que combina principios de las teorías: Elección Racional, Movilización de Recursos, Privación Relativa, Identidades Colectivas y Capital Social, se plantea la hipótesis que la par...

  11. Prevalencia de Blastocystis sp. y otros protozoarios comensales en individuos de Santa Rosa de Agua, Maracaibo, estado Zulia

    OpenAIRE

    Calchi La Corte, Marinella; Rivero de Rodríguez, Zulbey; Bracho Mora, Angela; Villalobos, Rafael; Acurero de Yamarte, Ellen; Maldonado, Adriana; Chourio-Lozano, Glenis; Díaz, Iris

    2013-01-01

    Con la finalidad de determinar la prevalencia de Blastocystis sp. y especies de protozoarios comensales intestinales del hombre según diferentes aspectos como la edad y el sexo, se evaluaron muestras de heces de 111 individuos varones y mujeres de todas las edades, pobladores de Santa Rosa de Agua, Maracaibo, estado Zulia. Cada muestra fecal se analizó a través de un examen al fresco, tinción de lugol y técnica de concentración de Ritchie. Se utilizó la tinción de hematoxilina férrica para id...

  12. Marketing estratégico en PYMEs fabricantes de prendas de vestir del estado de Zulia

    Directory of Open Access Journals (Sweden)

    Mariher Morales

    2005-01-01

    Full Text Available El objetivo del presente artículo es analizar los componentes del marketing estratégico en las pequeñas y medianas empresas (PYMEs fabricantes de prendas de vestir del estado Zulia. En el estudio se resalta como fundamento teórico la gestión del marketing sustentado en el proceso de planificación estratégica, cuya finalidad es evaluar el ambiente (interno y externo, definir la misión de la empresa, diseñar sus objetivos, establecer las estrategias a largo plazo y seleccionar los mercados. La investigación es de carácter descriptivo, teniendo como principal fuente de información un estudio de campo realizado en 27 PYMEs del sector. Entre los resultados de la investigación destacan que las organizaciones analizadas carecen de los principales lineamientos del proceso de planificación estratégica, además se evidenció que un 51,9% no elabora planes mercadológicos. Se concluye que las empresas no reflejan una orientación al mercado, pues se basan en la ejecución de tareas de comercialización y ventas, sin estrategias de largo plazo claramente definidas. Se observa el énfasis en la utilización de herramientas de marketing táctico y operativo, dejando a un lado el marketing estratégico como elemento clave que garantice el desarrollo de una ventaja competitiva.

  13. Estrategias de financiamiento aplicadas en el sector panadero del estado Zulia

    Directory of Open Access Journals (Sweden)

    Isabel Rangel

    2008-01-01

    Full Text Available El artículo tiene como propósito determinar las fuentes de financiamiento utilizadas por las pequeñas y medianas empresas procesadoras de harinas pulverizada, en virtud que se requieren recursos financieros para alcanzar el desarrollo del sector. La investigación fue descriptiva, de diseño no experimental. La población estuvo conformada por cuarenta pequeñas y medianas empresas del sector panadero del municipio Maracaibo inscritas en la asociación de panaderías, pastelerías y afines del estado Zulia (A.P.P.A.E.Z.. Se realizaron entrevistas a trece (13 gerentes de las empresas del sector que representan la muestra. Los resultados indican que el sector panadero está inmerso en una profunda crisis debido a la prolongada regulación del precio del pan, la liberación de los precios y el alza de la materia prima, lo cual ha afectado los niveles de liquidez, el flujo de caja, el capital de trabajo y la rentabilidad de las pequeñas y medianas empresas del sector. Las fuentes de financiamiento utilizadas fueron: el crédito comercial, los préstamos bancarios a corto y largo plazo, en condiciones poco favorables, y el aumento del capital social. Se propuso como estrategia otorgar en arrendamiento equipos y maquinarias ociosas, así como también optar por nuevas fuentes de financiamiento, fundamentalmente las promovidas por el Ejecutivo Nacional en apoyo a la pequeña y mediana empresa.

  14. Imagen corporativa sobre la Universidad del Zulia: Opinión y percepción de los líderes del estado Zulia

    Directory of Open Access Journals (Sweden)

    Efraín Rincón

    2003-01-01

    Full Text Available El artículo presenta la evaluación de las opiniones y percepciones que poseen los lideres de opinión de la ciudad de Maracaibo acerca de la Universidad del Zulia. Para ello, se conformaron las bases teóricas desde la filosofía mercadotecnista, asumiendo la posición de autores calificados en este campo del saber. Desde la perspectiva metodológica, el tipo de investigación fue descriptiva, con diseño no experimental de campo. La muestra fue de tipo intencional, compuesta por dieciséis (16 líderes de opinión, distribuidos en el municipio Maracaibo. Se utilizó como instrumento el cuestionario estructurado, aplicando la validez de contenido mediante una muestra de cinco (5 jueces expertos en el área de mercadeo y ventas. Además, se proporcionó al instrumento una confiabilidad objetiva dada por el orden lógico de las preguntas, la fluidez de las mismas y el grado en que el entrevistado pudo contestarlas con facilidad ya que la técnica de recolección de datos fue la entrevista cara a cara y el procesamiento de los mismos estuvo a cargo del Centro de Estadística e Investigación de Operaciones de la Facultad de Ciencias Económicas y Sociales (LUZ. Los resultados revelan que en opinión de los lideres zulianos, otras universidades son percibidas más favorablemente que LUZ, en su política comunicacional, a pesar que mayoritariamente se piense que es una institución fundamental en el proceso de desarrollo del estado Zulia. De igual manera, la información transmitida por sus medios, no satisface plenamente las necesidades que manifiestan los líderes regionales, con lo cual deja de aprovecharse efectivamente la importancia de la comunicación con su entorno más inmediato.

  15. Deficiencia de Vitamina A y Estado Nutricional Antropométrico en niños MarginalesUrbanos y Rurales en el Estado Zulia, Venezuela

    OpenAIRE

    Amaya-Castellanos, Daisy; Viloria-Castejón, Haydée; Ortega, Pablo; Gómez, Gisela; Urrieta, Jesús R; Lobo, Pablo; Estévez, Jesús

    2002-01-01

    El presente estudio transversal fue realizado para estimar la prevalencia de deficiencia de vitamina A (DVA) y desnutrición proteico-energética en una población infantil (24 a 85 meses) de tres barrios marginales urbanos de Maracaibo Estado Zulia, Venezuela (n=173) y de una zona rural (n=34), vecina a Maracaibo, por medio del análisis del retinol sérico y mediciones antropométricas, aplicando puntuación Z a los indicadores Talla//Edad (ZT//E); Peso//Edad (ZP//E) y Peso//Talla (ZP//T), compara...

  16. Los sistemas de información para el cuadro de mando integral en pequeñas y medianas empresas industriales en Maracaibo - Estado Zulia.

    OpenAIRE

    Kunath, Irene; Alizo, María Alexandra; Graterol, Angela

    2008-01-01

    Presentación. Presentation. Rengifo, Diana Economía / Economy: Los sistemas de información para el cuadro de mando integral en pequeñas y medianas empresas industriales en Maracaibo - estado Zulia. The systems of information for the of integral control design in small and medium companies industrial in Maracaibo, Zulia state. Kunath Irene; Alizo, María Alexandra; Graterol, Angela. Educación / Education: Los hipermapas. Alternativa pedagógica y didáctica para la...

  17. Impacto económico del dengue y del dengue hemorrágico en el Estado de Zulia, Venezuela, 1997-2003 Economic impact of dengue and dengue hemorrhagic fever in the State of Zulia, Venezuela, 1997-2003

    Directory of Open Access Journals (Sweden)

    Germán Añez

    2006-05-01

    Full Text Available OBJETIVOS: Determinar los costos directos e indirectos asociados con la atención de los casos de dengue y de dengue hemorrágico o síndrome de choque por dengue (DH/SCD entre los años 1997 y 2003 en el Estado de Zulia, Venezuela. MÉTODOS: El número total de pacientes con dengue y DH/SCD se obtuvo de los registros de la Dirección Regional de Epidemiología del Estado de Zulia y de los informes de casos confirmados en la Sección de Virología del Instituto de Investigaciones Clínicas Dr. Américo Negrette, de la Facultad de Medicina, Universidad del Zulia, Maracaibo, entre el 1.° de enero de 1997 y el 31 de diciembre de 2003. Como costos directos se consideraron el costo de la atención médica de urgencia de todos los casos y los costos de hospitalización de los casos con DH/SCD (costo por día-cama y costos de laboratorio. Los costos asociados con la ausencia laboral de los enfermos mayores de 15 años y de las madres acompañantes de los enfermos menores de 15 años conformaron los costos indirectos, ajustados según la proporción de hombres y mujeres en la fuerza laboral activa del país. Para el cálculo se utilizó el salario mínimo anual y los resultados se expresaron en dólares estadounidenses, según la tasa de cambio promedio de cada año. RESULTADOS: En el período estudiado se atendieron 33 857 casos de dengue y de DH/SCD; de ellos, 30 251 (89,35% fueron de dengue y 3 606 (10,65% de DH/SCD. Seis de estos fallecieron (letalidad 0,2 por 100 casos de DH/SCD. Los costos directos fueron US$ 474 251,70; de esa suma, US$ 132 042,30 correspondieron a la atención en los servicios de urgencia y US$ 342 209,40 a los gastos de hospitalización de los casos con DH/SCD. Los costos indirectos ascendieron a US$ 873 825,84 y representaron 64,8% del gasto total (US$ 1 348 077,54 relacionado con esta enfermedad en los años estudiados. CONCLUSIONES: Este es el primer estudio acerca del impacto económico del dengue en el Estado de Zulia y

  18. Iglesia y participación comunitaria en salud: el caso del Municipio San Francisco del estado Zulia, Venezuela

    Directory of Open Access Journals (Sweden)

    José Guillermo García

    2002-01-01

    Full Text Available Este trabajo tiene por objeto identificar en forma comparada los factores que condicionan la participación de las comunidades Betulio González y 24 de Julio del municipio San Francisco del estado Zulia en el subprograma de Medicina Natural que promociona la Iglesia Católica. Bajo un esquema conceptual que combina principios de las teorías: Elección Racional, Movilización de Recursos, Privación Relativa, Identidades Colectivas y Capital Social, se plantea la hipótesis que la participación de dichas comunidades en el subprograma está determinada por una serie de factores internos y externos en donde resaltan la representación social que tienen del subprograma, el cálculo racional de la acción, la tradición participativa y el apoyo organizativo de grupos voluntarios. Se empleó la perspectiva etnomedotológica en la realización de entrevistas en profundidad, de donde se extrajo como conclusión que existen factores comunes que condicionan la participación en ambas comunidades, tales como la reafirmación de una identidad femenina entendida como un incentivo para la acción, una representación colectiva positiva sobre la medicina natural y la presencia de recursos organizativos externos proporcionados por las escuelas ubicadas en cada comunidad, por grupos eclesiales de base y por la misma Iglesia Católica como agente promotor del subprograma.

  19. Fuentes de financiamiento utilizadas por las empresas productoras de derivados lácteos del estado Zulia

    Directory of Open Access Journals (Sweden)

    Mariby Boscán

    2007-01-01

    Full Text Available Actualmente, las empresas están viviendo transformaciones en muchos aspectos, para lo cual requieren la obtención de recursos financieros. El presente artículo tiene como objetivo determinar las fuentes de financiamiento públicas y privadas utilizadas por las empresas productoras de derivados lácteos del estado Zulia. Con esta finalidad, se realizó una investigación descriptiva y de campo, para lo cual se diseñó una entrevista aplicada a ocho gerentes. Entre los resultados destacan: Un 75% de los entrevistados, utilizan principalmente el crédito otorgado por FONCREI, como fuente pública, debido a que valoran fundamentalmente la tasa de interés; considerando además, que el acceso a este tipo de fuente es complicado (62,5%, y el tiempo de respuesta lento (87,5%. Como fuente de origen privado, figura el crédito con proveedores (62,5% siendo en este caso, el plazo otorgado por éstos el factor determinante; la mayoría de los empresarios estiman que el acceso a esta fuente es adecuado, los requisitos exagerados y el tiempo de respuesta adecuado. Se concluyó que el factor más importante en la decisión de solicitar el crédito público es la tasa de interés mientras que en las fuentes privadas, el plazo y monto del crédito son los factores más relevantes.

  20. LAS ORGANIZACIONES DE LA ECONOMÍA SOCIAL EN LA REFORMA DEL ESTADO EN VENEZUELA: CASO DEL ESTADO ZULIA 1989-2000

    Directory of Open Access Journals (Sweden)

    Gabriela Moran Leal

    2002-01-01

    Full Text Available A finales de la década de los 70 empieza a manifestarse en Venezuela la crisis del modelo de desarrollo, consistente en una grave situación económica, un gran déficit fiscal, problemas de gobernabilidad, así como elementos de fragmentación social, agudizados en la década de los 90 por los programas de estabilización económica. Por ello, desde 1984 se inicia el proceso de reforma del Estado, cuyos factores predominantes han sido la modernización política, la descentralización, la disminución del Estado social y los requerimientos de una mayor participación de la sociedad civil. Dentro del proceso de descentralización, iniciado en 1989, las gobernaciones promueven políticas de apoyo a las organizaciones de la economía social. El presente trabajo pretende caracterizar la política de la gobernación del estado Zulia dirigida a ese sector durante el periodo 1989-2000, a partir del enfoque de las políticas públicas, con una perspectiva crítico-descriptiva del proceso, por tratarse de una primera aproximación al objeto de estudio. Se construye un enfoque operativo sobre la definición de la economía social, su papel y su significación en los procesos de formulación económica y redefinición del Estado. Se avanza en la caracterización de las organizaciones estudiadas (microempresas, cooperativas y organizaciones no gubernamentales (ONGs, para luego puntualizar las estrategias políticas de los gobiernos. Se concluye, de manera parcial, en la descripción del proceso de formulación de políticas, donde ha predominado la visión utilitaria del sector, sin trascender los procesos organizativos reales que impulsen de manera significativa a estas organizaciones, para que impacten en la economía regional y nacional.

  1. Niveles de satisfacción de las empresas que utilizan el comercio electrónico como un canal de ventas en el estado Zulia

    Directory of Open Access Journals (Sweden)

    Vicente García

    2003-01-01

    Full Text Available Este estudio tuvo como propósito determinar los niveles de satisfacción de las empresas que utilizan el comercio electrónico como un canal de ventas en el Estado Zulia. La población estuvo conformada por 8 empresas con sitios de comercio electrónico en la web, ubicadas en el Estado Zulia. Como resultados se obtuvo que el crecimiento de esta nueva forma de mercadeo en las empresas zulianas es muy lento; los factores que, influyen en la selección del C.E. fueron: la competencia global, el cubrir nuevos nichos de mercado, la dispersión geográfica del mercado, los cambios tecnológicos...; las expectativas sobre el C.E. fueron mejorar la base de datos, aumentar el área de influencia geográfica, dar a conoce mejor la empresa y tener una buena aceptación; las percepciones sobre el C.E fueron: un mejoramiento en la participación de mercado, las ventajas competitivas, la logística operativa, el equilibrio entre oferta y demanda...; las empresas tuvieron un grado de satisfacción del 70% sobre una satisfacción máxima del l00%.

  2. Tecnologías de información en la toma de decisiones operativas en empresas petroleras del estado Zulia

    Directory of Open Access Journals (Sweden)

    Romero, Mildred

    2010-09-01

    Full Text Available Las tecnologías de información (TI han surgido como nuevas herramientas que transforman la manera tradicional de hacer las cosas, facilitando la automatización en actividades tanto operativas como administrativas en las organizaciones y mejorando el manejo de información. Atendiendo a la relevancia que han tomado las TI, el presente estudio se planteó como objetivo analizar la influencia de las tecnologías de información en la delegación de autoridad, y en la eficacia, eficiencia y efectividad de las decisiones operativas en las empresas del sector petrolero del estado Zulia. Fundamentándose para ello en los postulados de autores como Daft (2007, Domínguez et al. (1995, Fernández et al. (2003, Oz (2001, entre otros. La población objeto de estudio la conforman las empresas que prestan servicios a pozo. Llevándose a cabo una investigación de tipo descriptiva- transeccional con un diseño no experimental. Como resultado se pudo apreciar que las TI en las empresas del sector petrolero del estado Zulia han presentado mayor relevancia en la eficacia organizacional, es decir, han logrado las metas propuestas, sin embargo, los mismos resultados no son notorios en la eficiencia y efectividad. Palabras clave: Tecnologías de información, decisiones, operativo.

  3. Benchmarking: una herramienta para lograr un nivel de excelencia en las Escuelas de la Gobernación del Estado Zulia

    Directory of Open Access Journals (Sweden)

    Francisco Bracho Espinel*

    2004-05-01

    Full Text Available Dentro del marco de la gestión de calidad, cualquier organización puede recurrir a diversas herramientas metodológicas con el fin de conseguir los mejores resultados. Una de esas herramientas es el Benchmarking, que empleada en las organizaciones escolares, puede enriquecer las propias prácticas o sus modos de planificación, ejecución, control o evaluación. Conscientes de la compleja realidad de la educación venezolana, pero también de sus potencialidades, hemos considerado que este enfoque aplicado adecuadamente en las instituciones escolares de la Gobernación del Estado Zulia, puede generar mejoras y cambios sustanciales en todas las áreas de la organización escolar, y por ende en la prestación del servicio educativo.

  4. Características personales del líder transformacional en las contralorías municipales del Estado Zulia

    Directory of Open Access Journals (Sweden)

    Otilia del Socorro Bracho Parra

    2014-01-01

    Full Text Available El estudio tuvo como objetivo analizar las características personales del líder transformacional en las contralorías municipales; tomando como referencia los planteamientos de Bass y Avolio (2006, Maxwell (2007, Bass y Riggio (2006, entre otros. La investigación fue descriptiva con diseño no experimental transeccional descriptivo de campo. La población fue de 257 sujetos. Se seleccionó una muestra probabilística estratificada configurada por 157 informantes. Se utilizó un instrumento para medir la variable de estudio, el cual fue validado en su contenido y validez discriminante. El índice de confiabilidad del cuestionario correspondió a 0.984. Los datos fueron analizados con estadísticas descriptivas. Los resultados indicaron que son altas las características personales del líder transformacional en las contralorías municipales del estado Zulia. Los jefes de división como el personal administrativo coincidieron en sus apreciaciones. Lo cual les convierte en líderes propensos a ser modelos a seguir y que estimulan la motivación así como el interés de los seguidores por el logro de los objetivos organizacionales.Palabras Clave: Características personales; Liderazgo Transformacional; Contralorías Municipales.Personal characteristics of the transformational leader in the Zulia State municipal comptrollers AbstractThe study aimed to analyze the transformational leader´s characteristics in the municipal comptrollers, taking as reference the approaches by Bass and Avolio (2006, Maxwell (2007, Bass y Riggio (2006 and others. The research was descriptive with nonexperimental transactional descriptive design in the field. A stratified probability sample made of 157 informants was selected. An instrument of measuring was used to measure the variables of the study, which was validated in its content and discriminant validity. The index of reliability of the questionnaires corresponded to 0,984. Data was analyzed with descriptive

  5. Contabilidad de gestión ambiental en el ejercicio de la profesión del contador público en el estado Zulia

    Directory of Open Access Journals (Sweden)

    Romer Álvarez

    2009-01-01

    Full Text Available Actualmente resulta oportuno analizar el cumplimiento de la contabilidad de gestión ambiental en el ejercicio de la profesión del contador público para diagnosticar la situación que existe entre ambas, esto motivado a los problemas ambientales que adolece la sociedad. La contabilidad ambiental se encarga de la cuantificación y presentación de todos los aspectos medioambientales de la empresa. El ejercicio del contador público está dedicado a examinar y auditar registros contables, libros y estados financieros. La metodología consiste en la recopilación de información documental relacionada con estados financieros para su análisis y contrastación con las bases teóricas y jurídicas, además de las encuestas realizadas a los contadores públicos activos inscritos en el colegio respectivo del Municipio Maracaibo del Estado Zulia. A pesar de que existen regulaciones del Estado venezolano y para la profesión de la contaduría en materia ambiental, se evidencian ciertas debilidades por parte de los contadores públicos y de las empresas analizadas a través de sus estados financieros en el tratamiento de los hechos de impacto ambiental ocasionados por la actividad económica, lo cual origina un divorcio entre el contador público, la empresa, la contabilidad ambiental y la responsabilidad hacia la sociedad con el medio ambiente

  6. PRONÓSTICO DE LA RADIO ATENUACION TROSPOSFÉRICA POR LLUVIA PARA EL MUNICIPIO SAN FRANCISCO, ESTADO ZULIA, VENEZUELA, ENTRE 2016 Y 2018

    Directory of Open Access Journals (Sweden)

    José V. Castro V.

    2016-09-01

    Full Text Available El presente trabajo tiene como principal propósito pronosticar la radio atenuación troposférica por lluvia, también conocida como atenuación específica por lluvia, para el municipio San Francisco del estado Zulia, Venezuela, entre los años 2016 y 2018, utilizando el método ARIMA (Autoregressive Integrated Moving Average para series temporale, obtenidas a partir de datos de lluvia medidos en periodos diarios, mensuales y anuales. Mediante ARIMA, se determinó la intensidad de lluvia pronosticada, en mm/h, para los tres (3 años señalados, para seguidamente determinar la radio atenuación troposférica en dichos años. El procedimiento cumple con los requerimientos de estacionalidad y ciclicidad exigidos para ese tipo de pronósticos. Se observó que los niveles de radio atenuación troposférica más bajos se estiman ocurran aproximadamente para el periodo enero-abril, mientras que la radio atenuación más alta se prevé para el periodo julio-noviembre, con un pico en septiembre.

  7. LAS PYMES EN EL DESARROLLO DE LA ECONOMÍA SOCIAL. FACTORES DE ÉXITO1 SUBSECTOR CONTRATISTA DEL MUNICIPIO LAGUNILLAS DEL ESTADO ZULIA

    Directory of Open Access Journals (Sweden)

    Ivonne Acosta Campos

    2009-04-01

    Full Text Available El objetivo de esta investigación es identificar los factores endógenos que han influido en el desarrollo sustentable de las Pymes del subsector contratista adscritas a la Cámara de Comercio e Industrial del municipio Lagunillas del estado Zulia. La investigación se ubica en el nivel descriptivo. Se utilizó como fuente de recolección de datos la documental y la encuesta. Para el procesamiento de la información se utilizó el análisis de contenido a través de matrices de categorías. Los hallazgos encontrados revelan que los factores endógenos se ubican en las siguientes categorías: (a económicos (b financieros, (c técnicos, (d talento humano, (e gerenciales. Se concluye que los factores internos incidentes en el desarrollo sustentable de las Pymes se ubican en las diferentes áreas de funcionamiento de las empresas.

  8. Aproximación a un estudio sobre las lesiones del bahareque en el estado Zulia, Venezuela. Algunas recomendaciones para su intervención

    Directory of Open Access Journals (Sweden)

    Henneberg de León, A.

    2012-03-01

    Full Text Available The bahareque is a constructive technique made by four components of different materials: wood colums, canning, illing and mud-cover. These components suffer different damages, therefore when repairing these walls different solutions are required for each component. This article presents the first results of a field research, that studied the more frequent damages that undergo these components, and it proposes some recommendations for its repair, based on rehabilitations done in the Zulia State and in the construction of a baharequewall. It was possible to establish that the greater amount of damages was physical and mechanical and they occurred in the mud-cover, component exposed to the environment. The other components only deteriorate when they are uncovered. This study try to offer a source for future researches about the pathology of the bahareque; besides, it can contribute to revalue this technique, being even considered as a technical option for the construction of houses.

    El bahareque es una técnica constructiva formada por cuatro componentes hechos de materiales diversos: horconadura, enlatado, relleno y empanetado. Estos componentes sufren diferentes lesiones, por lo que para su intervención son requeridas distintas soluciones para cada uno. Este artículo presenta los primeros resultados de una investigación de campo que estudió las lesiones más frecuentes que sufren dichos componentes, al igual que propone recomendaciones para su intervención, basadas en rehabilitaciones hechas en el Estado Zulia y en la construcción de una pared de bahareque. Se pudo determinar que la mayor cantidad de lesiones son físicas y mecánicas y se producen en el empanetado, componente expuesto al ambiente. Los otros componentes, se lesionan solo cuando quedan al descubierto. Este estudio intenta servir de base para futuros estudios sobre la patología del bahareque; además, de contribuir a la revalorización de esta técnica, pudiendo ser

  9. Gestión de Tecnología en Empresas de Clase Mundial del Sector Bebidas en Venezuela Caso: Municipio San Francisco – Estado Zulia

    Directory of Open Access Journals (Sweden)

    Francisco Batlle Rois Méndez

    2014-01-01

    Full Text Available La investigación se planteó como objetivo analizar la gestión de tecnología en empresas de clase mundial delsector bebidas del municipio San Francisco del estado Zulia, Venezuela. Para alcanzar el objetivo propuesto se revisaron los postulados del Modelo Nacional de Tecnología (MNT (2009 y los aportes teóricos de autores como Gaynor (1999, Peters (2006 y Bosch (2000, en relación con la gestión de tecnología. El estudio fue de tipo descriptivo bajo un diseño de campo, no experimental-transeccional y con una muestra constituida por seis sujetos encargados de gerenciar tecnología en las unidades productivas de la Cervecería Polar y Pepsi de Venezuela. Los resultados obtenidos, mediante el cuestionario utilizado para la recolección de información, permitieron concluir que la gestión de tecnología, en dichas empresas, se desarrolla de manera empírica con una configuración funcional en la cual no existen estándares establecidos en cuanto a su integración con la gestión del conocimiento ni en la necesidad de generar unidades de I+D que tengan foco en la gestión de la tecnología. Sin embargo, el reconocimiento del impacto de la gestión tecnológica en los resultados positivos de la empresa condujo a reconocer mejores prácticas y experiencia a través de las actividades de vigilancia, planeación, habilitación, protección e implantación tecnológica.Palabras Clave: Gestión; tecnología; conocimiento; competitividad. Management of Technology in the Business World Class Beverages Sector in Venezuela Case: San Francisco County - Zulia StateAbstractThe main purpose of this research was to analyze the technology management in world-class companies belonging to the drinking sector at the San Francisco county, Zulia State, Venezuela. The tenets of National Model for Technology (MNT (2009 and the theoretical contributions of authors such as Gaynor (1999, Peters (2006 and Bosch (2000, in relation to the management of technology were

  10. Relación entre geohelmintiasis intestinales y variables químicas, hematológicas e IgE, en una comunidad yukpa del estado Zulia, Venezuela

    OpenAIRE

    Rivero de Rodríguez, Zulbey; Churio, Osmaly; Bracho Mora, Angela; Calchi La Corte, Marinella; Acurero, Ellen; Villalobos, Rafael

    2012-01-01

    Para relacionar helmintiasis intestinales y parámetros hematológicos, bioquímicos y serológicos, se estudiaron 37 individuos yukpas del municipio Perijá, estado Zulia, durante el año 2009. Las muestras de heces se evaluaron mediante el concentrado con formol-éter, Kato-Katz y cultivo de Harada-Mori. Los parámetros hematológicos, las proteínas totales, albúminas, globulinas y relación A/G, fueron determinados por autoanalizadores hematológicos y bioquímicos. La IgE fue determinada por ELISA. 7...

  11. Crédito de instituciones públicas municipales y regionales a las microempresas y empresas de la economía solidaria del Estado Zulia, Venezuela Periodo 2000-2009

    Directory of Open Access Journals (Sweden)

    María Isabel Serrano Montiel

    2012-12-01

    Full Text Available Se analiza el financiamiento otorgado por las instituciones públicas municipales y regionales a las microempresas y empresas de la economía solidaria del Estado Zulia, Venezuela. Con información suministrada de las instituciones incluidas en el estudio (y Corpozulia, se examinan las condiciones del financiamiento, la cobertura geográfica de los créditos, las actividades económicas financiadas y la condición sociodemográfica de los beneficiarios. Para ello se utilizó estadística descriptiva, lo que hace que el estudio sea de carácter no experimental. Se concluye que las instituciones antes mencionadas se ajustan a lo que establece la Ley de Microfinanzas en lo relacionado a la cobertura en la extensión territorial del Estado Zulia. En su gran mayoría, los créditos fueron otorgados a mujeres, los jóvenes han sido los menos beneficiados.

  12. Florística y fisonomía de un matorral xerófilo espinoso intervenido en Punta de Piedras, Municipio Miranda, Estado Zulia, Venezuela

    Directory of Open Access Journals (Sweden)

    Antonio Vera

    2009-06-01

    Full Text Available Se determinaron los aspectos florísticos y fisonómicos de un matorral xerófilo espinoso intervenido de Punta de Piedras, municipio Miranda, estado Zulia, Venezuela. Se realizaron dieciséis muestreos quincenales, entre noviembre 2005 y junio 2006, para la recolecta, identificación y conteo de las especies tanto en el periodo lluvioso como en el seco. Los muestreos se llevaron a cabo en 10 manchones de vegetación con un área promedio de 718 ± 706.24 m², en una formación graminiforme en la que se emplearon tres parcelas de 20 x 20 (400 m², dividiéndose cada una de éstas en cuatro subparcelas de 20 x 5 (100 m² y a su vez, dentro de ellas, se delimitaron 12 subparcelas de 1 x 1. (1 m², y también se realizaron recorridos para el reconocimiento de otras especies de la zona. El matorral xerófilo espinoso mostró evidencias de intervención antropogénica como quemas periódicas, deposición de desechos sólidos, caminerías para el tránsito de las personas y asentamientos poblacionales en las zonas circunvecinas; y presentó una vegetación semiárida de espinar costero característica y comparable a la señalada para otras regiones del país. Se identificaron 45 especies agrupadas en 22 familias, entre las cuales destacaron: las Poaceae (6, Mimosaceae (4, Boraginaceae (3, Cactaceae (3 Caesalpinaceae (3, Euphorbiaceae (3 y Fabaceae (3. La intervención antropogénica parece generar la aparición de manchones de vegetación arbustiva y arbórea y de una formación graminiforme o pastizal. En esta última, Aristida venesuelae, Aristida pittieri y Portulaca pilosa presentaron los mayores valores de abundancia y frecuencia relativa cuya sumatoria corresponde a 49.38% y 46.86%, respectivamente; mientras que en los manchones se destacaron dos estratos: uno herbáceo menor a 1 m, y otro estrato arbustivo-arbóreo de bajo porte (2.63 ± 1.37 m de altura media, conformado principalmente por Opuntia wentiana, Piptadenia flava y Jatropha

  13. Prevalencia de enteroparásitos en individuos de centros de rehabilitacion a drogas del estado Zulia, Venezuela | Prevalence of enteroparasites in individuals of drug rehabilitation centers in Zulia state–Venezuela

    Directory of Open Access Journals (Sweden)

    Ángela Bracho Mora

    2017-11-01

    Full Text Available To determine the prevalence of intestinal parasites in drug-addicted individuals that have been detained in two rehabilitation centers in Zulia state, a cross-sectional descriptive study was accomplished in which 98 fecal samples from persons of both sexes, aged between 15 and 65 years, were collected. The samples were analyzed by direct and concentrated examination with the coproparasitological Formalin-ether (Ritchie method; likewise, the staining technique Kinyoun was used to search for intestinal coccidia. The overall prevalence of intestinal parasites was 70.41%; among them, 56.52% of individuals were monoparasitized and 43.48% polyparasitized. Up to three parasitic associations were found in each individual. With respect to the parasite species found, Blastocystis spp. (62.24% was the most frequent in terms of chromist/protozoas and within helminths, Hookworms were found in 6.12% of individuals and occupied the first place in prevalence. The highest percentage of parasitized individuals was observed in young adults (20-39 years with 63.77%, but no significant difference was observed with other age groups. Significant differences (p < 0.001 were observed amongst individuals that were parasitized with respect to the drug consumed, with a higher prevalence among individuals that had consumed cocaine. It has been concluded that the drug situation does not seem to be an important variable that promotes or limits the acquisition of common intestinal parasites, as sanitary conditions remain to be critical in acquiring them.

  14. Detección y diferenciación de Entamoeba histolytica y Entamoeba dispar mediante reacción en cadena de la polimerasa en individuos de una comunidad del Estado Zulia, Venezuela Detection and differentiation of Entamoeba histolytica and Entamoeba dispar by polymerase chain reaction in a community in Zulia State, Venezuela

    Directory of Open Access Journals (Sweden)

    Zulbey Rivero

    2009-01-01

    Full Text Available La identificación diferencial de Entamoeba histolytica y Entamoeba dispar es esencial para un tratamiento adecuado del paciente y con fines epidemiológicos. Para determinar la prevalencia de E. histolytica y E. dispar se estandarizó y aplicó un ensayo de PCR, utilizando oligonucleótidos específicos para cada especie. 204 muestras de heces de individuos de la comunidad de Santa Rosa de Agua (Municipio Maracaibo, Estado Zulia, Venezuela, fueron analizadas a través del examen directo con SSF (0,85% y lugol, concentrado de formol-éter y PCR. Al examen microscópico, 42 individuos (20,58% presentaron formas evolutivas del complejo E. histolytica/E. dispar; mientras que la técnica de PCR evidenció un total de 47 casos positivos a estas amibas; de los cuales 22 eran portadores de E. histolytica (10,78%, 16 (7,84% de E. dispar y 9 (4,41% presentaron infección mixta. No hubo diferencia significativa al relacionar las variables sexo y presencia de E. histolytica y/o E. dispar, ni con los grupos etarios. No existieron casos de estas amibas, en los menores de 2 años. La frecuencia observada de E. histolytica (31/204, demuestra el carácter endémico de la amibiasis en esta comunidad.Differential identification of Entamoeba histolytica and Entamoeba dispar is essential for both appropriate patient treatment and epidemiological purposes. To determine the prevalence of these amoeba infections in Santa Rosa de Agua (Maracaibo, Zulia State, Venezuela, a PCR assay using specific primers for each species was standardized and applied. 204 stool samples were analyzed through direct microscopic examination with SSF (0.85% and lugol, formol-ether concentration, and PCR. Under direct microscopy, 42 individuals (20.58% presented the E. histolytica/E. dispar complex. Meanwhile PCR showed 47 positive cases for these amoebas: 22 E. histolytica (10.78%, 16 E. dispar (7.84%, and 9 (4.41% mixed infections. There was no significant difference in the presence of E

  15. Plan de actividades físico - recreativas para contribuir a la incorporación de los adultos mayores al círculo de abuelos de la comunidad Moralito, municipio Colón, Estado de Zulia

    Directory of Open Access Journals (Sweden)

    Yariel González Galván

    2011-03-01

    Full Text Available La población adulta mayor de la comunidad Moralito, municipio Colón, estado de Zulia, en la República Bolivariana de Venezuela, muestra una baja incorporación a la práctica del ejercicio físico en esta etapa de la vida, por lo que se hace necesario incrementar la participación de estas personas en los Círculos de Abuelos; por tanto, se ha tomado como muestra para la realización de este trabajo la comunidad perteneciente al módulo de salud ubicado en la zona urbana de Moralito. Para hacer el estudio se tuvo en cuenta la cantidad de personas de la tercera edad que residen en la comunidad para aplicar un diagnóstico inicial partiendo particularmente de las necesidades de cada uno de ellos, de ahí que se aplicaron entrevistas a los incorporados al Círculo de Abuelos, que son los menos, a los no incorporados, así como al médico que trabaja en el módulo de salud, estas sirvieron de apoyo para obtener una información más detallada y desarrollar la investigación. Además se realizaron observaciones a las clases del Círculo de Abuelos de la comunidad seleccionada.

  16. Dosimetry of radon, thorium and their progenies in the environment of a chemistry lab and crude in Zulia State, Venezuela; Dosimetria de radon, toron y sus progenies en el entorno de un laboratorio de quimica y crudo en el Estado Zulia, Venezuela

    Energy Technology Data Exchange (ETDEWEB)

    Pineda, L.; Viloria, T., E-mail: lendavaI22@hotmail.com, E-mail: lpineda@fing.luz.edu.ve, E-mail: tviloria63@yahoo.es [Universidad del Zulia, Maracaibo (Venezuela, Bolivarian Republic of). Departamento de Fisica; Palacios, D.; Sajo-Bohus, L., E-mail: sajobohus@gmail.com, E-mail: sanjuro.perdomo@gmail.com [Universidad Simon Bolivar, Caracas (Venezuela, Bolivarian Republic of). Laboratorio de Fisica Nuclear

    2013-07-01

    The main objective of this study was to estimate the dose rate of inhalation and the annual contribution of effective dose in the mixed field of radon and thoron in the environment of laboratory chemicals and oil from Zulia State, Venezuela, due to manipulation and storage of oil samples and water production.

  17. Correlación entre niveles de ferritina sérica y unidades de transfusión recibidas por pacientes con anemias hereditarias hemolíticas en el estado de Zulia, Venezuela

    Directory of Open Access Journals (Sweden)

    Ana Z. Ruiz E

    2014-04-01

    Full Text Available La hipertransfusión es un tratamiento comúnmente utilizadas en pacientes con anemias hemolíticas hereditarias (AHH, como la anemia de células falciformes (ACS y/o beta talasemia (βT. Las concentraciones de ferritina sérica son constantemente monitoreadas en estos pacientes para detectar rápidamente la presencia de sobrecarga de hierro. El objetivo del estudio fue determinar si hubo correlación entre los valores de ferritina sérica y el número de unidades de transfusión de concentrado eritrocitario suministradas a los pacientes con ACS y βT mayor o intermedia durante un año. Se realizó un estudio prospectivo de 39 pacientes,22 fueron diagnosticados de ACS y 17 con βT, en edades comprendidas entre los 4 y 82 años. Estos pacientes fueron tratados en el "Instituto Hematológico de Occidente -Banco de Sangre del Estado Zulia y el Hospital Universitario de Maracaibo Venezuela”. Ferritina sérica se determinó por el método de quimioluminiscencia. La media y la desviación estándar de ferritina fueron 915,4 ± 567,8 ng/ml para los pacientes con ACS y 3.338 ± 874,6 para βT (p: 0.0001 Las unidades de concentrado eritrocitario transfundidas fueron 6 ± 2,3 y 21 ± 7,5 respectivamente (p: 0.0001. Hubo correlación estadísticamente significativa entre el número de unidades de concentrado eritrocitario transfundidas y los valores de ferritina sérica en el grupo de ACS (r=0,832, p=0,0001 y el grupo βT (r=0,491, p=0,045. Los resultados del presente estudio sugieren una estrecha correlación entre las concentraciones de ferritina sérica y las unidades de concentrado eritrocitario transfundidas en los pacientes con ACS pero no en los pacientes con βT. Correlations between ferritin levels and transfusion units received by pacients with hereditary hemolytic anemia in the state of Zulia, Venezuela Abstract Blood transfusions are a commonly used treatment or patients with hereditary hemolytic anemias, such as: sickle cell anemia (SCA and

  18. la Universidad del Zulia (LUZ

    Directory of Open Access Journals (Sweden)

    Marisol Fucci

    2006-01-01

    Full Text Available Actualmente los servicios de información y las relaciones interinstitucionales, se traducen en acciones y potencialidades que ninguna organización puede desasistir.Este artículo tiene como objetivo diseñar un modelo de gestión de los servicios de información concebidos bajo el enfoque de la gerencia estratégica, para optimar las Relaciones Interinstitucionales en la Universidad del Zulia. Para lograr el objetivo propuesto se ha elaborado un estudio descriptivo. Como técnica de recolección de datos se diseñó un instrumento tipo cuestionario aplicado a una muestra de 382 personas, dividida de la siguiente manera: 315 estudiantes de pregrado, 17 estudiantes de postgrado, 33 docentes y 17 empleados; para medir las variables servicio de información y sus dimensiones, necesidades informativas, satisfacci ón y expectativas de los usuarios, tipos de servicios, definición de políticas y normas. Finalmente se concluye que es necesario: 1 la operatividad del Modelo de gestión de los servicios informativos bajo el enfoque de la gerencia estratégica para la DRI, a fin de alcanzar la formulación, ejecución y evaluación de estrategias que permitan el mejor funcionamiento y desarrollo de los servicios; 2 operacionalizar la efectiva gestión para las políticas del servicio de información, lo cual permitirá, guiar las metas y objetivos propuestos con mayor claridad, oportunidad, fluidez y coordinación; 3 definir estrategias, orientadas a la promoción y difusión de los servicios de información bajo los parámetros de asertividad, veracidad y oportunidad, lo cual garantizará la consolidación y efectividad de las relaciones interinstitucionales

  19. Til lykke eller Rita

    DEFF Research Database (Denmark)

    Agger, Gunhild

    2012-01-01

    Med Rita og Lykke har den satiriske sædekomedie fået en renæssance. Sædekomedien lever af at udstille normbrud og satirisere over menneskenes omgangsformer og kommunikation eller mangel på samme. Det er netop det, der sker i Rita og Lykke, hvor det outrerede eksponeres for at latterliggøres....

  20. Las tecnologías de la información en el sector petrolero de los municipios Santa Rita y Simón Bolívar*

    Directory of Open Access Journals (Sweden)

    Moisés Briez

    2009-09-01

    Full Text Available El objetivo del presente trabajo consiste en analizar los componentes de las tecnologías de la información -Hardware, Software, Bases de Datos y Telecomunicaciones- y el alcance que éstos tienen en las empresas del sector petrolero de los municipios Santa Rita y Simón Bolívar del Estado Zulia. La fundamentación teórica utilizada para el desarrollo del presente artículo se baso en los siguientes autores: OBrien (2001, Laudon y Laudon (1996, Krajewski y Ritzman (2000, entre otros. La investigación fue descriptiva con un diseo no experimental transeccional, se aplicó un muestreo intencional para seleccionar las empresas petroleras en las cuales se realizó la investigación mediante entrevistas semi-estructuradas y análisis de documentos relacionados. Entre las conclusiones obtenidas, se evidencia que las empresas petroleras emplean de manera significativa los componentes de las TI logrando mayores niveles de eficiencia en las operaciones administrativas organizacionales; sin embargo, la investigación también revela que algunas de las empresas estudiadas no cuentan con tecnología de información para aplicaciones científicas y de ingeniería necesarias para ofrecer servicios más complejos.

  1. TEACHING ENTREPENEURSHIP AT ADMINISTRCTIONS SCHOOL IN THE UNIVERSITY OF ZULIA

    OpenAIRE

    René Hernandez; Karin Silvestri; Anjuli Alvarez; Joel Cobis

    2009-01-01

    The investigation is framed within the research management training developed in the Management Development Research Group at the University of Zulia. The goal was to determine the teaching undertaken in the management training of school administration from the University of Zulia. The methodology was descriptive, by field study the population was comprised of students from the course of administrative systems at the school of administration at East Coast Lake Maracaibo in 2007. The results w...

  2. Rita Bottoms: Polyartist Librarian

    OpenAIRE

    Bottoms, Rita; Reti, Irene; Regional History Project, UCSC Library

    2005-01-01

    Project Director Irene Reti conducted fourteen hours of interviews with Rita Bottoms, Head of Special Collections at the University Library, UC Santa Cruz, shortly before her retirement in March 2003. This oral history provides a vivid and intimate look at thirty-seven years behind the scenes in the library's Special Collections. For thirty-seven years Bottoms dedicated herself to collecting work by some of the most eminent writers and photographers of the twentieth century, includin...

  3. Ang Rita 1

    OpenAIRE

    Loomis, Molly

    2012-01-01

    .wav and .mp3 versions of audio file Ang Rita describes in Sherpa difference aspects of his life as a yak herder and yak herding culture. Tape includes native names for yak, birth and death ceremonies; castration practices; differences between Sherpa and Tibetan customs regarding yaks; herding yaks as a child; herding calls; interactions with wolves; grazing practices; concerns about decline of yak herding and the environmental consequences; the future of yak herding; famous yak herders; t...

  4. Interview: Rita Colwell

    OpenAIRE

    Alucozai, Milad

    2012-01-01

    Dr. Rita Colwell is a renowned microbiologist and infectious disease expert as well as a Purdue Alumna. She served as the 11th director of the National Science Foundation (NSF) from 1998 to 2004. Currently, she serves as the President and CEO of CosmosID and is a Distinguished Professor at both the University of Maryland and Johns Hopkins University School of Public Health.

  5. Zulia rich coal seams to fuel Venezuela

    Energy Technology Data Exchange (ETDEWEB)

    1983-06-16

    In March, 1982, Carbozulia awarded a contract to Fluor Corp. to provide basic engineering services, including mine planning and geology, for the two-phase project. The open pit mine and ancillary facilities, valued at more than $200 million, will provide steam and metallurgical coal for domestic use. The site, Mina Paso Diablo, is located about 60 miles northwest of Maracaibo. Upon phase one completion sometime in 1987, the mill will start production, gradually increasing to 4 million metric-tons-per-year. This will increase to 6.4 million metric tons when phase two is completed. In addition to the mine, the Venezuelan government plans to build an industrial complex along Lake Maracaibo. Corpozulia will build a steel-rolling mill and add a 350,000 metric tons-per-year coking oven, which will consume about 7% of the mine's metallurgical-coal production. Another government-owned firm, Electric Energy of Venezuela, plans to build a thermo-electric plant nearby. Two 250-megawatt units are planned initially, with potential to add another six units. At full capacity, the plant will burn more than 90% of the coal produced from the mine. Mina Paso Diablo contains one of Latin America's largest proven coal reserves - about 350 million metric tons - with guesstimates running as high as 4 billion metric tons for the Zulia coal basin. The coal is of superior quality, running about 12,000 to 13,000 Btu's per lb. with a low ash and sulphur content.

  6. Gestión del programa Barrio Adentro: su expresión en el Zulia

    Directory of Open Access Journals (Sweden)

    María T. Rincón Becerra

    2007-01-01

    Full Text Available Los cambios impulsados en la política social por parte del gobierno nacional a raíz de las transformaciones del marco institucional a finales de 1998, dieron paso al diseño de una nueva estrategia organizativa en materia de salud pública. Este trabajo tiene como objetivo explorar la política y gestión del programa Barrio Adentro en el Estado Zulia. Se adelantó una investigación de tipo exploratoria-descriptiva, la cual se fundamentó en la revisión de documentos oficiales y hemerobibliográficos, así como en entrevistas realizadas a informantes clave de la gestión a nivel regional del programa. Los resultados revelan: 1 desarrollo de una política central implementada de manera paralela a la que venia ejecutándose por parte del aparato de Estado, 2 presencia convergente de multiplicidad de instituciones del Estado, 3 estructura de decisiones desconcentrada-horizontal, 4 su fuente de financiamiento proviene del Estado, 5 el personal goza de estabilidad laboral, 6 el personal directivo funciona bajo el régimen de comisión de servicio, 7 servicio prestado de manera gratuita y sobre la base de la Atención Primaria. Se concluye que Barrio Adentro se ha desarrollado bajo un estilo de gestión paralelo a las formas tradicionales de afrontar la organización de los sistemas de salud.

  7. TEACHING ENTREPENEURSHIP AT ADMINISTRCTIONS SCHOOL IN THE UNIVERSITY OF ZULIA

    Directory of Open Access Journals (Sweden)

    René Hernandez

    2009-07-01

    Full Text Available The investigation is framed within the research management training developed in the Management Development Research Group at the University of Zulia. The goal was to determine the teaching undertaken in the management training of school administration from the University of Zulia. The methodology was descriptive, by field study the population was comprised of students from the course of administrative systems at the school of administration at East Coast Lake Maracaibo in 2007. The results was obtained that knowledge management systems in the department regarding the organization, is a cornerstone to enhance their learning. We conclude that the learning strategies employed to manage the management tools such as organizational charts, administrative manuals, flowcharts etc.; let you be aware of the importance of procedures and processes in any organization and encouraged the teaching of undertaken as part of management training.

  8. Hurricane Rita Poster (September 22, 2005)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Rita poster. Multi-spectral image from NOAA-16 shows Hurricane Rita as a category-4 hurricane in the Gulf of Mexico on September 22, 2005. Poster size is...

  9. Proteomic profiling of white muscle from freshwater catfish Rita rita.

    Science.gov (United States)

    Mohanty, Bimal Prasanna; Mitra, Tandrima; Banerjee, Sudeshna; Bhattacharjee, Soma; Mahanty, Arabinda; Ganguly, Satabdi; Purohit, Gopal Krishna; Karunakaran, Dhanasekar; Mohanty, Sasmita

    2015-06-01

    Muscle tissues contribute 34-48 % of the total body mass in fish. Proteomic analysis enables better understanding of the skeletal muscle physiology and metabolism. A proteome map reflects the general fingerprinting of the fish species and has the potential to identify novel proteins which could serve as biomarkers for many aspects of aquaculture including fish physiology and growth, flesh quality, food safety and aquatic environmental monitoring. The freshwater catfish Rita rita of the family Bagridae inhabiting the tropical rivers and estuaries is an important food fish with high nutritive value and is also considered a species of choice in riverine pollution monitoring. Omics information that could enhance utility of this species in molecular research is meager. Therefore, in the present study, proteomic analysis of Rita rita muscle has been carried out and functional genomics data have been generated. A reference muscle proteome has been developed, and 23 protein spots, representing 18 proteins, have been identified by MALDI-TOF/TOF-MS and LC-MS/MS. Besides, transcript information on a battery of heat shock proteins (Hsps) has been generated. The functional genomics information generated could act as the baseline data for further molecular research on this species.

  10. Chk2 mediates RITA-induced apoptosis.

    Science.gov (United States)

    de Lange, J; Verlaan-de Vries, M; Teunisse, A F A S; Jochemsen, A G

    2012-06-01

    Reactivation of the p53 tumor-suppressor protein by small molecules like Nutlin-3 and RITA (reactivation of p53 and induction of tumor cell apoptosis) is a promising strategy for cancer therapy. The molecular mechanisms involved in the responses to RITA remain enigmatic. Several groups reported the induction of a p53-dependent DNA damage response. Furthermore, the existence of a p53-dependent S-phase checkpoint has been suggested, involving the checkpoint kinase Chk1. We have recently shown synergistic induction of apoptosis by RITA in combination with Nutlin-3, and we observed concomitant Chk2 phosphorylation. Therefore, we investigated whether Chk2 contributes to the cellular responses to RITA. Strikingly, the induction of apoptosis seemed entirely Chk2 dependent. Transcriptional activity of p53 in response to RITA required the presence of Chk2. A partial rescue of apoptosis observed in Noxa knockdown cells emphasized the relevance of p53 transcriptional activity for RITA-induced apoptosis. In addition, we observed an early p53- and Chk2-dependent block of DNA replication upon RITA treatment. Replicating cells seemed more prone to entering RITA-induced apoptosis. Furthermore, the RITA-induced DNA damage response, which was not a secondary effect of apoptosis induction, was strongly attenuated in cells lacking p53 or Chk2. In conclusion, we identified Chk2 as an essential mediator of the cellular responses to RITA.

  11. Mineral content of the honey produced in Zulia state, Venezuela.

    Science.gov (United States)

    Sulbarán de Ferrer, Betzabé; Ojeda de Rodríguez, Graciela; Peña, Jorge; Martínez, Janeth; Morán, María

    2004-09-01

    The mineral content of the honey produced in five zones of the Zulia state, Venezuela, during dry and rainy seasons was determined. The analyzed elements were: sodium, potassium (by emission spectroscopy), calcium, magnesium, copper, iron, manganese (by atomic absorption spectroscopy), phosphorus (phosphate ions, by colorimetric method), and ash content of raw honey samples directly collected from different beekeepers. The mean values for Na, K, Ca, Mg, Cu, Fe, Mn, and P were 353+84; 1774+138; 237+66; 52+24; 0.76+0.43; 13.5+10.23; 0.92+0.42 and 1642+323 mg/kg respectively. The mean ash content was 0.431+0.15%. Potassium was the most abundant of the elements determined. This results confirm that Zulian honey can be considered a good source of minerals.

  12. 27 CFR 9.162 - Sta. Rita Hills.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Sta. Rita Hills. 9.162.... Rita Hills. (a) Name. The name of the viticultural area described in this section is “Sta. Rita Hills”. For purposes of part 4 of this chapter, “Sta. Rita Hills” is a term of viticultural significance. (b...

  13. RITA-type triple axis spectrometers

    International Nuclear Information System (INIS)

    Roennow, H.M.

    2001-01-01

    The RITA spectrometer at Risoe National Laboratory was the first to incorporate a complete re-thinking of the neutron-path from source, through detector to analysis. Since then, other RITA-type spectrometers such as SPINS at NIST, RITA-II at PSI have been built, and several new spectrometers around the world are adapting the same philosophy. The main novelty of RITA was the introduction of a single back-end tank featuring both an analyser block with multiple individually turnable analyser blades and a 2D position sensitive detector. Several new triple-axis spectrometers are presently being built at existing and future sources, and almost all of them have learnt from the experience with RITA. (R.P.)

  14. Complete mitochondrial genome of the Freshwater Catfish Rita rita (Siluriformes, Bagridae).

    Science.gov (United States)

    Lashari, Punhal; Laghari, Muhammad Younis; Xu, Peng; Zhao, Zixia; Jiang, Li; Narejo, Naeem Tariq; Deng, Yulin; Sun, Xiaowen; Zhang, Yan

    2015-01-01

    The complete mitochondrial genome of Catfish, Rita rita, was isolated by LA PCR (TakaRa LAtaq, Dalian, China); and sequenced by Sanger's method to obtain the complete mitochondrial genome, which is listed Critically Endangered and Red Listed species. The complete mitogenome was 16,449 bp in length and contains 13 typical vertebrate protein-coding genes, 2 rRNA and 22 tRNA genes. The whole genome base composition was estimated to be 33.40% A, 27.43% C, 14.26% G and 24.89% T. The complete mitochondrial genome of catfish, Rita rita provides the basis for genetic breeding and conservation studies.

  15. Avaliação sorológica para detecção de anticorpos anti-Leishmania em cães e gatos no bairro de Santa Rita de Cássia, Município de Barra Mansa, Estado do Rio de Janeiro Serological evaluation for detection of anti-Leishmania antibodies in dogs and cats in the district of Santa Rita de Cássia, municipality of Barra Mansa, State of Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Fabiano Borges Figueiredo

    2009-04-01

    Full Text Available A partir de um caso canino de leishmaniose tegumentar americana na localidade de Santa Rita de Cássia, município de Barra Mansa, Rio de Janeiro, foi realizado um inquérito sorológico em 177 cães e 43 gatos. Na avaliação das amostras de soros caninos, 10% foram positivos na reação de imunofluorescência indireta e 10,7% no ensaio imunoenzimático. Entre as amostras de soros felinos testados, nenhum animal foi positivo na reação de imunofluorescência indireta e apenas um (2,4% felino apresentou reação positiva ao ensaio imunoenzimático. A detecção de Leishmania braziliensis, autóctone em Barra Mansa, faz um alerta para a instalação de um possível foco de leishmaniose tegumentar americana nessa região.From a canine case of american cutaneous leishmaniasis in the locality of Santa Rita de Cássia, municipality of Barra Mansa, Rio de Janeiro, a serological survey was performed on 177 dogs and 43 cats. Evaluation of the canine serum samples showed that 10% had a positive reaction in the indirect immunofluorescence test and 10.7% in the enzyme-linked immunosorbent assay. Among the feline serum samples tested, none of the animals had a positive reaction in the indirect immunofluorescence test and only one (2.4% showed a positive reaction in the enzyme-linked immunosorbent assay. The detection of an autochthonous case of Leishmania braziliensis in Barra Mansa gives warning that a focus of american cutaneous leishmaniasis is possibly becoming established in this region.

  16. Calidad del agua y sedimento en el lago de Maracaibo, estado Zulia

    Directory of Open Access Journals (Sweden)

    Giovany José-Bracho

    2016-03-01

    Full Text Available Se analizó el agua y el sedimento del lago de Maracaibo en seis estaciones de muestreo distribuidas de norte a sur del lago. Los parámetros físicoquímicos y ambientales fueron determinados y establecidas las relaciones entre estos y las áreas afectadas por descargas de aguas residuales, depósitos de basura, residuos industriales líquidos y sólidos, actividad petrolera y agrícola y materiales orgánicos acarreados por ríos y drenajes pluviales. Se evidenció la contaminación por incremento de utrientes(nitrógeno y fósforo en las zonas influenciadas por los ríos y vertederos de agua residual y se validó la presencia de una cuña salina por la penetración al lago de las aguas del golfo de Venezuela. Las concentraciones de metalespesados están por debajo de los límites permisibles para el agua; en los sedimentos es muy heterogénea.

  17. TENDENCIAS DEL NEGOCIO DE LAS TELEVISORAS Y PRODUCTORAS COMERCIALES EN EL ESTADO ZULIA

    Directory of Open Access Journals (Sweden)

    Rocío Belandria Cerdeira

    2005-07-01

    Full Text Available Este artículo presenta los resultados de un estudio de campo cuyo objetivo fue identificar las tendencias del negocio en las televisoras y productoras comerciales de la región zuliana. El estudio es de carácter exploratorio, realizado a partir de un trabajo de campo. Se aplicó una entrevista de preguntas abiertas a una muestra no probabilistica intencionada de cuatro televisoras y tres productoras de televisión comerciales de la región. La metodología es cualitativa por lo que el interés está dirigido a la descripción verbal que los informantes proporcionan de los hechos más que su medición. Los resultados arrojados indican que: 1 el negocio de las televisoras se afianza mayormente en la venta de espacios; 2 para las productoras el negocio en crear, producir y atender las necesidades del cliente, 3 el negocio está apalancado en el mercadeo y utiliza variadas estrategias direccionadas en forma descendente desde la gerencia, 4 se arrojan ganancias; y 5 el sector aparece en pleno crecimiento a pesar de la crisis del país.

  18. Lens proteome map and alpha-crystallin profile of the catfish Rita rita.

    Science.gov (United States)

    Mohanty, Bimal Prasanna; Bhattacharjee, Soma; Das, Manas Kumar

    2011-02-01

    Crystallins are a diverse group of proteins that constitute nearly 90% of the total soluble proteins of the vertebrate eye lens and these tightly packed crystallins are responsible for transparency of the lens. These proteins have been studied in different model and non-model species for understanding the modifications they undergo with ageing that lead to cataract, a disease of protein aggregation. In the present investigation, we studied the lens crystallin profile of the tropical freshwater catfish Rita rita. Profiles of lens crystallins were analyzed and crystallin proteome maps of Rita rita were generated for the first time. alphaA-crystallins, member of the alpha-crystallin family, which are molecular chaperons and play crucial role in maintaining lens transparency were identified by 1- and 2-D immunoblot analysis with anti-alphaA-crystallin antibody. Two protein bands of 19-20 kDa were identified as alphaA-crystallins on 1-D immunoblots and these bands separated into 10 discrete spots on 2-D immunoblot. However, anti-alphaB-crystallin and antiphospho-alphaB-crystallin antibodies were not able to detect any immunoreactive bands on 1- and 2-D immunoblots, indicating alphaB-crystallin was either absent or present in extremely low concentration in Rita rita lens. Thus, Rita rita alpha-crystallins are more like that of the catfish Clarias batrachus and the mammal kangaroo in its alphaA- and alphaB-crystallin content (contain low amount from 5-9% of alphaB-crystallin) and unlike the dogfish, zebrafish, human, bovine and mouse alpha-crystallins (contain higher amount of alphaB-crystallin from 25% in mouse and bovine to 85% in dogfish). Results of the present study can be the baseline information for stimulating further investigation on Rita rita lens crystallins for comparative lens proteomics. Comparing and contrasting the alpha-crystallins of the dogfish and Rita rita may provide valuable information on the functional attributes of alphaA- and alphaB-isoforms, as

  19. Looking at the future with Rita.

    Science.gov (United States)

    Bentivoglio, M

    2013-11-12

    This paper on Rita Levi-Montalcini (1909-2012), who received in 1986 the Nobel Prize in Physiology or Medicine for the discovery of nerve growth factor, focuses on aspects of her advocacy and her commitment to education in which she has been especially active in the last part of her long life. With passionate confidence on the capabilities of the aging brain (together with severe admonition against the pursuit of immortality), she encouraged contributions of senior citizens to the society. Always projected into the future, with enduring faith in the potential of young individuals, in education as a key to development, in the capabilities of women, in the importance of gender equality, Rita established in 2001 the Rita Levi-Montalcini Foundation for the education of African women. Her legacy on engagement for a better 'global village' should not be forgotten by the neuroscience community.

  20. Realizing the full potential of a RITA spectrometer

    DEFF Research Database (Denmark)

    Lefmann, K.; Niedermayer, C.; Abrahamsen, A.B.

    2006-01-01

    The “re-invented triple-axis spectrometer (RITA) concept has existed for a decade. Recent developments at RITA-2 at PSI, have revealed more of the potential of this instrument class. We demonstrate the performance of the multi-blade imaging mode, which has been applied e.g. to studies of dispersion...... relations and emphasize the power of this mode in combination with the low background of RITA-2. In addition, we present other ways of utilizing the position sensitive detector in a RITA instrument. Simulations of a planned upgrade of the guide-monochromator system at RITA-2 have shown a potential...

  1. La fuente oral en la reconstrucción de la memoria histórica: su aporte al documental "Memorias del Zulia Petrolero"

    Directory of Open Access Journals (Sweden)

    Nilda Bermúdez Briñez

    2009-01-01

    Full Text Available La historia debe incorporar el recuerdo en los procesos de rememorización del pasado como una fuente valiosa para la transmisión y preservación de la memoria colectiva y utilizar los testimonios orales en la elaboración de discursos históricos distintos a los escritos. Esto es lo que pretende el documental videográfico "Memorias del Zulia petrolero" propuesta que estudia el impacto del petróleo en este espacio geohistórico durante las primeras décadas del siglo veinte, integrando fuentes iconográficas de todo tipo, incluidas la voz y la imagen de actores sociales vinculados a ese proceso. Mediante la técnica de la entrevista grabada en video se rescata el testimonio oral como fuente para la producción de conocimiento histórico y se busca acercar la historia a los hombres y mujeres comunes, darle rostro a la palabra que ha estado silenciada o ausente en muchas investigaciones históricas. En este artículo se presenta una reflexión acerca del uso de la oralidad en los estudios históricos, el aporte del registro audiovisual en la construcción de la fuente testimonial y los aspectos metodológicos de la experiencia de trabajo llevada a cabo en Cabimas, Lagunillas, Mene Grande y Maracaibo para el documental histórico "Memorias del Zulia petrolero".

  2. Antibacterial properties of the skin mucus of the freshwater fishes, Rita rita and Channa punctatus.

    Science.gov (United States)

    Kumari, U; Nigam, A K; Mitial, S; Mitial, A K

    2011-07-01

    The skin mucus of Rita rita and Channa punctatus was investigated to explore the possibilities of its antibacterial properties. Skin mucus was extracted in acidic solvents (0.1% trifluoroacetic acid and 3% acetic acid) and in triple distilled water (aqueous medium). The antibacterial activity of the mucus extracts was analyzed, using disc diffusion method, against five strains of bacteria--the Gram-positive Staphylococcus aureus and Micrococcus luteus; and the Gram negative Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi. In both Rita rita and Channa punctatus, the skin mucus extracted in acidic solvents as well as in aqueous medium show antibacterial activity against Staphylococcus aureus and Micrococcus luteus. Nevertheless, the activity is higher in acidic solvents than that in aqueous medium. The acidic mucus extracts of Rita rita, show antibacterial activity against Salmonella typhi as well. The results suggest that fish skin mucus have bactericidal properties and thus play important role in the protection of fish against the invasion of pathogens. Fish skin mucus could thus be regarded as a potential source of novel antibacterial components.

  3. Krimmi-Rita juubelituur Eestimaal / Enda Trubok

    Index Scriptorium Estoniae

    Trubok, Enda

    2010-01-01

    Kontši-Savva ehk Krasnodarka küla eesti seltsi esinaisel Rita Kadilkinal (neiupõlvenimi Kuusk), kelle esivanemad 1862. aastal Järvamaalt – Albu vallast – Krimmi paremaid maid otsima läksid, täitus septembris 70 eluaastat, mille puhul otsustaski ta Eestisse tulla

  4. Las industrias azucarera y petrolera en el Zulia: formas de ocupación territorial (1913-1935

    Directory of Open Access Journals (Sweden)

    Nilda Bermúdez Briñez

    2012-02-01

    Full Text Available Este artículo tiene como objetivo fundamental explicar las distintas formas de apropiación y ocupación de las tierras ubicadas al este y al sur del estado Zulia, situado al occidente de Venezuela, en donde los capitales criollos y extranjeros representados en compañías anónimas invirtieron recursos económicos con la finalidad de instalar las industrias azucareras y petroleras que monopolizaron en poco tiempo extensos territorios para la exploración y explotación de la caña de azúcar y del petróleo. Ambos procesos cabalgaron en diferentes ritmos históricos, con desiguales actores sociales pero en tiempos análogos. La industrialización de estos rubros requirió de amplios espacios que adquirieron y modificaron los líderes de las corporaciones en la medida que lograban comprar, traspasar, negociar, contratar, desalojar y hasta expropiar tierras, casas, animales, fundos, hatos, haciendas o labores agrícolas privadas y públicas, apoyados en la legislación de la época, en sus relaciones con la municipalidad y con el gobierno del general Juan Vicente Gómez. La libertad y el respaldo que gozaron los socios de ambas empresas los llevó a transformar la infraestructura tradicional y adecuarla a las exigencias de las corporaciones que se consolidaban: por primera vez en el país, se instalaron novedosos equipos y maquinarias manejados con tecnologías modernas que requirió de un personal competente y de mano de obra abundante. En este trabajo se utilizó el método histórico como herramienta científica para el abordaje y  análisis del tema.

  5. [Cryptosporidium sp infections and other intestinal parasites in food handlers from Zulia state, Venezuela].

    Science.gov (United States)

    Freites, Azael; Colmenares, Deisy; Pérez, Marly; García, María; Díaz de Suárez, Odelis

    2009-03-01

    Cryptosporidiosis in food handlers from Venezuela is unknown, being this an important public health problem in immunosuppressed patients. To determine the prevalence of Cryptosporidium sp and other intestinal parasites in food handlers from Zulia State, one hundred nineteen fecal samples were evaluated by wet mount, concentrated according to Ritchie and modified Ziehl-Neelsen staining. Fourteen (11.8%) were positive for Cryptosporidium sp and associated with other protozoosis (P Entamoeba coli (17.6%). The most frequent pathogenic protozoa was Giardia lamblia (13.4%), followed by the complex Entamoeba histolytica/E. dispar (9.2%). 4.1% were positive for intestinal helminthes. The infection by Cryptosporidium sp is frequent in food handlers from Zulia State. Given to the results of this investigation and the nonexistence of studies in this population, is necessary to deepen in the impact of this parasitism in food handlers and the consumers of their products.

  6. Management of technical documents: a projection at the University of Zulia

    Directory of Open Access Journals (Sweden)

    Ana Judith Paredes Chacin

    2015-11-01

    Full Text Available Objective. This paper analyze comprehensively and systematically the principles of organization and technical procedure, which support document management based on the use of information technologies. Method. We developed a study based on the documentary descriptive method in the context of the Dirección de Infraestructura (Dinfra from the Universidad del Zulia. Results. We find evidence of efficiency in the processes that support the management of technical documents: Plans, metrics and memories generated by the Dinfra. Conclusion. The conceptual basis of organizational and technical archives contribute to the systematization, shelter save and documental preservation, and ensure the timely retrieval of technical information for the management of the University of Zulia.

  7. Retention of Displaced Students after Hurricanes Katrina and Rita

    Science.gov (United States)

    Coco, Joshua Christian

    2017-01-01

    The purpose of the study was to investigate the strategies that university leaders implemented to improve retention of displaced students in the aftermaths of Hurricanes Katrina and Rita. The universities that participated in this study admitted displaced students after Hurricanes Katrina and Rita. This study utilized a qualitative…

  8. Simulations and experiments on RITA-2 at PSI

    DEFF Research Database (Denmark)

    Klausen, S.N.; Lefmann, K.; McMorrow, D.F.

    2002-01-01

    The cold-neutron triple-axis spectrometer RITA-2 designed and built at Riso National Laboratory was installed at the neutron source SINQ at Paul Scherrer Institute in April/May 2001. In connection with the installation of RITA-2, computer simulations were performed using the neutron ray...

  9. Realizing the full potential of a RITA spectrometer

    International Nuclear Information System (INIS)

    Lefmann, K.; Niedermayer, Ch.; Abrahamsen, A.B.; Bahl, C.R.H.; Christensen, N.B.; Jacobsen, H.S.; Larsen, T.L.; Haefliger, P.; Filges, U.; Ronnow, H.M.

    2006-01-01

    The 're-invented triple-axis spectrometer (RITA) concept has existed for a decade. Recent developments at RITA-2 at PSI, have revealed more of the potential of this instrument class. We demonstrate the performance of the multi-blade imaging mode, which has been applied e.g. to studies of dispersion relations and emphasize the power of this mode in combination with the low background of RITA-2. In addition, we present other ways of utilizing the position sensitive detector in a RITA instrument. Simulations of a planned upgrade of the guide-monochromator system at RITA-2 have shown a potential to increase the flux at the sample position by a factor 5

  10. Realizing the full potential of a RITA spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Lefmann, K. [Riso National Laboratory, Frederiksborgvej 399, DK-4000 Roskilde (Denmark)]. E-mail: kim.lefmann@risoe.dk; Niedermayer, Ch. [Laboratory for Neutron Scattering, ETH-Zuerich and Paul Scherrer Institut, CH-5232 Villilgen (Switzerland); Abrahamsen, A.B. [Riso National Laboratory, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Bahl, C.R.H. [Riso National Laboratory, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Christensen, N.B. [Riso National Laboratory, Frederiksborgvej 399, DK-4000 Roskilde (Denmark): Laboratory for Neutron Scattering, ETH-Zuerich and Paul Scherrer Institut, CH-5232 Villilgen (Switzerland); Jacobsen, H.S. [Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhagen O (Denmark); Larsen, T.L. [Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhagen O (Denmark); Haefliger, P. [Laboratory for Neutron Scattering, ETH-Zuerich and Paul Scherrer Institut, CH-5232 Villilgen (Switzerland); Filges, U. [Laboratory for Neutron Scattering, ETH-Zuerich and Paul Scherrer Institut, CH-5232 Villilgen (Switzerland); Ronnow, H.M. [Laboratory for Neutron Scattering, ETH-Zuerich and Paul Scherrer Institut, CH-5232 Villilgen (Switzerland)

    2006-11-15

    The 're-invented triple-axis spectrometer (RITA) concept has existed for a decade. Recent developments at RITA-2 at PSI, have revealed more of the potential of this instrument class. We demonstrate the performance of the multi-blade imaging mode, which has been applied e.g. to studies of dispersion relations and emphasize the power of this mode in combination with the low background of RITA-2. In addition, we present other ways of utilizing the position sensitive detector in a RITA instrument. Simulations of a planned upgrade of the guide-monochromator system at RITA-2 have shown a potential to increase the flux at the sample position by a factor 5.

  11. Morphological observation and length-weight relationship of critically endangered riverine catfish Rita rita (Hamilton).

    Science.gov (United States)

    Amin, M R; Mollah, M F A; Taslima, K; Muhammadullah

    2014-01-15

    The experiment was conducted to investigate the morphological status of the critically endangered riverine catfish Rita rita using morphometric and meristic traits. About 158 species of Rita were collected from the old Brahmaputra river in Mymensingh district and were studied in the laboratory of the Fisheries Biology and Genetics Department, Bangladesh Agricultural University. Measurement of length and weight of Rita were recorded by using measuring scale and electric balance respectively. Significant curvilinear relationship existed between total length and other morphometric characters and between head length and other characters of the head. Relationships between total length and various body measurements of the fish were highly significant (p < 0.01) except the relationship between total length and pelvic fin length of male fish (p < 0.05). In case of meristic characters-dorsal fin rays, pelvic fin rays, pectoral fin rays, anal fin rays, caudal fin rays, number of vertebrae and branchiostegal rays were found to be more or less similar except slight differences. The values of condition factors (k) in the total length body-weight relationships for female and male were found to be 0.41 and 0.38, respectively. The mean values of relative condition factors (kn) were 1.0 and 1.005 for female and male, respectively.

  12. [Case reports of drug-induced liver injury in a reference hospital of Zulia state, Venezuela].

    Science.gov (United States)

    Mengual-Moreno, Edgardo; Lizarzábal-García, Maribel; Ruiz-Soler, María; Silva-Suarez, Niniveth; Andrade-Bellido, Raúl; Lucena-González, Maribel; Bessone, Fernando; Hernández, Nelia; Sánchez, Adriana; Medina-Cáliz, Inmaculada

    2015-03-01

    Drug-induced liver injury (DILI) is an important cause of morbidity and mortality worldwide, with varied geographical differences. The aim of this prospective, descriptive, cross-sectional study was to identify and characterize cases of DILI in a hospital of Zulia state, Venezuela. Thirteen patients with a presumptive diagnosis of DILI attended by the Department of Gastroenterology, Hospital Universitario, Zulia state, Venezuela, from December-2012 to December-2013 were studied. Ibuprofen (n = 3; 23.1%), acetaminophen (n = 3; 23.1), isoniazid (n = 2; 15.4%) and Herbalife products (n = 2; 15.4%) were the main drugs involved with DILI. Acetaminophen and ibuprofen showed a mixed pattern of liver injury (n = 3; 23.1%) and isoniazid presented a hepatocellular pattern (n = 2; 15.4%). The CIOMS/RUCAMS allowed the identification of possible (n = 7; 53.9%), probable (n = 4; 30.8%) and highly-probable cases (n = 2; 15.4%) of DILI. Amoxicillin/clavulanate, isoniazid, isotretinoin, methotrexate and Herbalife nutritional products were implicated as highly-probable and probable agents. The highest percentage of DILI corresponded to mild cases that recovered after the discontinuation of the agent involved (n = 9; 69.3%). The consumption of Herbalife botanical products is associated with probable causality and fatality (n = 1; 7.7%). In conclusion, the frequency of DILI cases controlled by the Department of Gastroenterology of the Hospital Universitario of Maracaibo was low, being ibuprofen, acetaminophen, isoniazid and products Herbalife the products most commonly involved. It is recommended to continue with the prospective registration of cases, with an extended follow up monitoring period and to facilitate the incorporation of other hospitals in the Zulia State and Venezuela.

  13. Orígenes de los Estudios de la Mujer en la Universidad del Zulia

    OpenAIRE

    Oneida Chirino Ferrer

    2008-01-01

    En este trabajo se presenta el resultado parcial de una investigación sobre los Estudios de la Mujer en la Universidad del Zulia. Básicamente se aborda una parte del desarrollo histórico de dichos Estudios, para contextualizar la importancia de esta área académica que ha permitido analizar exhaustivamente la problemática de la situación de las mujeres y reflexionar en torno al problema del género. En este caso desde la filosofía se ha podido desarrollar un enfoque tanto teórico como metodol...

  14. RITA: The reinvented triple axis spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Mason, T.E. [Toronto Univ., ON (Canada). Dept. of Physics; Clausen, K.N.; Aeppli, G.; McMorrow, D.R.; Kjems, J.K. [Risoe National Lab., Roskilde (Denmark)

    1995-11-01

    Risoe National Laboratory was reported to be in the process of developing a new spectrometer design, RITA, based on the triple axis design. The spectrometer will attempt to incorporate more recent innovations such as multilayer supermirrors and microstrip proportional counters into a rethinking of the triple-axis spectrometer. By optimizing the beam optics, using supermirrors and extending the analyser to map regions of (Q, {omega}) space using an array of independently controllable pyrolytic graphite crystals focussed on an area detector, it was hoped that the efficiency of single-crystal inelastic experiments could be increased by as much as a factor of 20. 7 figs., 20 refs.

  15. RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles.

    Science.gov (United States)

    Pietkiewicz, Adrian L; Zhang, Yuqi; Rahimi, Marwa N; Stramandinoli, Michael; Teusner, Matthew; McAlpine, Shelli R

    2017-04-13

    The established cytotoxic agent RITA contains a thiophene-furan-thiophene backbone and two terminal alcohol groups. Herein we investigate the effect of using thiazoles as the backbone in RITA-like molecules and modifying the terminal groups of these trithiazoles, thereby generating 41 unique structures. Incorporating side chains with varied steric bulk allowed us to investigate how size and a stereocenter impacted biological activity. Subjecting compounds to growth inhibition assays on HCT-116 cells showed that the most potent compounds 7d , 7e , and 7h had GI 50 values of 4.4, 4.4, and 3.4 μM, respectively, versus RITA (GI 50 of 800 nM). Analysis of these compounds in apoptosis assays proved that 7d , 7e , and 7h were as effective as RITA at inducing apoptosis. Evaluating the impact of 7h on proteins targeted by RITA (p53, c-Myc, and Mcl-1) indicated that it acts via a different mechanism of action to that of RITA. RITA suppressed Mcl-1 protein via p53, whereas compound 7h suppressed Mcl-1 expression via an alternative mechanism independent of p53.

  16. Dosimetry of radon, thorium and their progenies in the environment of a chemistry lab and crude in Zulia State, Venezuela

    International Nuclear Information System (INIS)

    Pineda, L.; Viloria, T.; Palacios, D.; Sajo-Bohus, L.

    2013-01-01

    The main objective of this study was to estimate the dose rate of inhalation and the annual contribution of effective dose in the mixed field of radon and thoron in the environment of laboratory chemicals and oil from Zulia State, Venezuela, due to manipulation and storage of oil samples and water production

  17. Calidad de servicio en la editorial de la Universidad del Zulia (EDILUZ

    Directory of Open Access Journals (Sweden)

    Edith Atencio Cárdenas

    2007-01-01

    Full Text Available El objetivo del presente artículo es determinar la calidad del servicio que ofrece la Editorial de la Universidad del Zulia, de acuerdo con la percepción, expectativas y nivel de satisfacción de los usuarios. El tipo de investigación fue descriptiva, con diseño de campo, no experimental, para lo cual se elaboró y aplicó un instrumento de recolección de datos en la Universidad del Zulia a una muestra donde intervinieron 45 usuarios. Los resultados indicaron que la calidad en la prestación del servicio según la percepción de los encuestados es favorable en los aspectos de fiabilidad, empatía y tangibilidad; a excepción del aspecto capacidad de respuesta. En cuanto a las expectativas, los usuarios esperan obtener el mejor de los servicios por parte de la institución, siendo negativa la capacidad de respuesta. En cuanto al nivel de satisfacción se demostró un resultado positivo relacionado a los aspectos de fiabilidad, empatía y tangibilidad, mientras que la capacidad de respuesta se presenta con un resultado negativo.Se concluye que las expectativas esperadas por los usuarios son mayores a las percibidas derivando de los usuarios que acuden a demandar el servicio de EDILUZ un nivel de satisfacción negativo.

  18. Children and Trauma: A Post-Katrina and Rita Response

    Science.gov (United States)

    Hebert, Barbara B.; Ballard, Mary B.

    2007-01-01

    Many children have struggled to cope with the traumatic experiences brought about by hurricanes Katrina and Rita. This article recounts how the authors intervened in the lives of children and families after the storms. (Contains 3 figures.)

  19. Rita Felski, The Limits of Critique

    Directory of Open Access Journals (Sweden)

    Corrado Confalonieri

    2017-05-01

    Full Text Available Professore di Letteratura inglese presso la University of Virginia – e dal 2016 Niels Bohr Professor alla University of Southern Denmark per un progetto quinquennale dedicato agli usi sociali della letteratura –, Rita Felski non è, all’interno del gruppo di studiosi che lavorano negli Stati Uniti, tra quelli più noti al pubblico italiano, e ciò non soltanto perché mancano traduzioni dei suoi libri, ma per il fatto che diversi tra questi sono rivolti a un contesto piuttosto specificamente americano. Non fa eccezione The Limits of Critique, il libro che qui si presenta e che dovrebbe costituire la seconda uscita di una trilogia avviata nel 2008 con Uses of Literature (Wiley-Blackwell e destinata a concludersi con un volume ora in fase di elaborazione dedicato al coinvolgimento estetico e alle ragioni per cui, come lettori o spettatori, siamo affascinati da un’opera d’arte.

  20. Enfoques gerenciales modernos en el proceso de cambio organizacional de la Universidad del Zulia

    Directory of Open Access Journals (Sweden)

    Elvira Anniccharico

    2002-05-01

    Full Text Available El presente trabajo es una investigación de tipo descriptiva, que está basada en la información suministrada por los directivos de las dependencias seleccionadas a través de un cuestionario elaborado para tal fin y cuyo objetivo es determinar el grado de aplicabilidad de los enfoques gerenciales modernos (EGM en los procesos del cambio de la Universidad del Zulia. Los resultados evidencian que el Mejoramiento Continuo de Procesos el el EGM más utilizado; pero a pesar de haber realizado esfuerzos para su aplicación, existen algunos aspectos institucionales que debilitan significativamente la incidencia en su efectividad. Se concluye que para la aplicación efectiva de los EGM debe definirse lineamientos estratégicos enmarcados en un contexto, partiendo del análisis de los factores facilitadores y obstaculizadores, donde se oriente el cambio hacia la personalidad de la organización.

  1. Rita Kirke: "Taimed on minu head õpetajad ja toetajad" / Rita Kirke

    Index Scriptorium Estoniae

    Kirke, Rita

    2006-01-01

    Elukutselisi aiakujundajaid tutvustavas sarjas vastab küsimustele läti aiakujundaja Rita Kirke. R. Kirkest, tema tähtsamad tööd. R. Kirke endast, oma õpetajatest, oma aiast ja töödest, Läti oludesse sobivast ja tüüpilisest Läti aiast, koostööst klientidega, lemmiktaimedest, taimede kättesaadavusest Lätis jpm. Ill.: R. Kirke portreefoto, 6 ill. tema töödest

  2. Espiritismo: Educação e Estado Laico

    Directory of Open Access Journals (Sweden)

    Artur Cesar Isaia

    2017-05-01

    Full Text Available Este artigo enfoca o posicionamento do discurso espírita francês do século XIX frente à educação. O discurso espírita é enfocado a partir de fontes históricas organizacionais, importantes para a compreensão da sua importância frente a outros agentes produtores de significados sociais, como o estado e as demais religiões. O posicionamento do Espiritismo francês frente à educação é enfocado relacionando-o com sua luta pela laicização do estado e da sociedade na França do período pós-revolucionário. Desta forma vamos encontrar um posicionamento não apenas favorável à laicização, mas que, principalmente a partir da segunda metade do século XIX, vai estreitar laços com os adversários da Igreja Católica. A questão era a luta contra o papel ainda de destaque da Igreja Católica no terreno educacional, mesmo no período pós-revolucionário. De maneira saliente vamos ter a relação entre Espiritismo e Maçonaria, ambos defendendo um estado, uma sociedade e uma educação laica para a França.

  3. Mapping Hurricane Rita inland storm tide

    Science.gov (United States)

    Berenbrock, Charles; Mason, Jr., Robert R.; Blanchard, Stephen F.; Simonovic, Slobodan P.

    2009-01-01

    Flood-inundation data are most useful for decision makers when presented in the context of maps of effected communities and (or) areas. But because the data are scarce and rarely cover the full extent of the flooding, interpolation and extrapolation of the information are needed. Many geographic information systems (GIS) provide various interpolation tools, but these tools often ignore the effects of the topographic and hydraulic features that influence flooding. A barrier mapping method was developed to improve maps of storm tide produced by Hurricane Rita. Maps were developed for the maximum storm tide and at 3-hour intervals from midnight (0000 hour) through noon (1200 hour) on September 24, 2005. The improved maps depict storm-tide elevations and the extent of flooding. The extent of storm-tide inundation from the improved maximum storm-tide map was compared to the extent of flood-inundation from a map prepared by the Federal Emergency Management Agency (FEMA). The boundaries from these two maps generally compared quite well especially along the Calcasieu River. Also a cross-section profile that parallels the Louisiana coast was developed from the maximum storm-tide map and included FEMA high-water marks.

  4. Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance.

    Science.gov (United States)

    Bu, Yiwen; Cai, Guoshuai; Shen, Yi; Huang, Chenfei; Zeng, Xi; Cao, Yu; Cai, Chuan; Wang, Yuhong; Huang, Dan; Liao, Duan-Fang; Cao, Deliang

    2016-12-28

    Inactivation of p53 occurs frequently in various cancers. RITA is a promising anticancer small molecule that dissociates p53-MDM2 interaction, reactivates p53 and induces exclusive apoptosis in cancer cells, but acquired RITA resistance remains a major drawback. This study found that the site-differential phosphorylation of nuclear factor-κB (NF-κB) RelA/p65 creates a barcode for RITA chemosensitivity in cancer cells. In naïve MCF7 and HCT116 cells where RITA triggered vast apoptosis, phosphorylation of RelA/p65 increased at Ser536, but decreased at Ser276 and Ser468; oppositely, in RITA-resistant cells, RelA/p65 phosphorylation decreased at Ser536, but increased at Ser276 and Ser468. A phosphomimetic mutation at Ser536 (p65/S536D) or silencing of endogenous RelA/p65 resensitized the RITA-resistant cells to RITA while the phosphomimetic mutant at Ser276 (p65/S276D) led to RITA resistance of naïve cells. In mouse xenografts, intratumoral delivery of the phosphomimetic p65/S536D mutant increased the antitumor activity of RITA. Furthermore, in the RITA-resistant cells ATP-binding cassette transporter ABCC6 was upregulated, and silencing of ABCC6 expression in these cells restored RITA sensitivity. In the naïve cells, ABCC6 delivery led to RITA resistance and blockage of p65/S536D mutant-induced RITA sensitivity. Taken together, these data suggest that the site-differential phosphorylation of RelA/p65 modulates RITA sensitivity in cancer cells, which may provide an avenue to manipulate RITA resistance. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  5. Una alianza en temas seguridad entre México y Estados Unidos

    OpenAIRE

    Lina María Mejía; Estefanía Aristizabal

    2013-01-01

    Reseña del siguiente libro:VELÁZQUEZ FLORES, Rafael y Juan Pablo Prado Lallande (coords.) (2009). La Iniciativa Mérida: ¿nuevo paradigma de cooperaciónentre México y Estados Unidos en seguridad?. México: Benemérita Universidad Autónoma de Puebla/Universidad Nacional Autónoma de México. 441 pp.

  6. Una alianza en temas seguridad entre México y Estados Unidos

    Directory of Open Access Journals (Sweden)

    Lina María Mejía

    2013-12-01

    Full Text Available Reseña del siguiente libro:VELÁZQUEZ FLORES, Rafael y Juan Pablo Prado Lallande (coords. (2009. La Iniciativa Mérida: ¿nuevo paradigma de cooperaciónentre México y Estados Unidos en seguridad?. México: Benemérita Universidad Autónoma de Puebla/Universidad Nacional Autónoma de México. 441 pp.

  7. Added flexibility in triple axis spectrometers: The two RITAs at Risø

    DEFF Research Database (Denmark)

    Lefmann, K.; McMorrow, D.F.; Rønnow, H.M.

    2000-01-01

    The cold-neutron triple-axis spectrometer RITA-I at Rise has been operational for about three years, and in the near future an improved version, RITA-2 will replace the existing triple-axis instrument TAS7. We review the performance of RITA-1 and the operation modes of its flexible secondary...... spectrometer, giving examples of a few key experiments, and describe the software developed for running it. Further, the design of the new RITA-2 instrument is presented. The two RITA spectrometers are compared with their sister instrument SPINS at NIST and with similar instruments planned elsewhere. (C) 2000...

  8. Simulations and experiments on RITA-2 at PSI

    International Nuclear Information System (INIS)

    Klausen, S.N.; Lefmann, K.; McMorrow, D.F.; Altorfer, F.; Janssen, S.; Luethy, M.

    2002-01-01

    The cold-neutron triple-axis spectrometer RITA-2 designed and built at Riso National Laboratory was installed at the neutron source SINQ at Paul Scherrer Institute in April/May 2001. In connection with the installation of RITA-2, computer simulations were performed using the neutron ray-tracing package McStas. The simulation results are compared to real experimental results obtained with a powder sample. Especially, the flux at the sample position and the resolution function of the spectrometer are investigated. (orig.)

  9. Ambient Assisted Living and ageing: preliminary results of RITA project.

    Science.gov (United States)

    Aquilano, Michela; Cavallo, Filippo; Bonaccorsi, Manuele; Esposito, Raffaele; Rovini, Erika; Filippi, Massimo; Esposito, Dario; Dario, Paolo; Carrozza, Maria Chiara

    2012-01-01

    The ageing of population is a social phenomenon that most of worldwide countries are facing. They are, and will be even more in the future, indeed trying to find solutions for improving quality of life of their elderly citizens. The project RITA wants to demonstrate that an update of the current socio-medical services with an Ambient Assisted Living (AAL) approach could improve the service efficiency and the quality of life of both elderly and caregiver. This paper presents the preliminary results obtained in RITA.

  10. Simulations and experiments on RITA-2 at PSI

    Science.gov (United States)

    Klausen, S. N.; Lefmann, K.; McMorrow, D. F.; Altorfer, F.; Janssen, S.; Lüthy, M.

    The cold-neutron triple-axis spectrometer RITA-2 designed and built at Riso National Laboratory was installed at the neutron source SINQ at Paul Scherrer Institute in April/May 2001. In connection with the installation of RITA-2, computer simulations were performed using the neutron ray-tracing package McStas. The simulation results are compared to real experimental results obtained with a powder sample. Especially, the flux at the sample position and the resolution function of the spectrometer are investigated.

  11. RITA inhibits growth of human hepatocellular carcinoma through induction of apoptosis.

    Science.gov (United States)

    Wang, Haihe; Chen, Guofu; Wang, Hongzhi; Liu, Chunbo

    2013-01-01

    RBP-J-interacting and tubulin-associated (RITA) is a novel RBP-J-interacting protein that downregulates Notch-mediated transcription. The current study focuses on the antitumor effect of RITA in human hepatocellular carcinoma (HCC) and aims to explore its molecular mechanism. Thirty paired HCC and adjacent non-tumoral liver samples were analyzed by real-time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). RITA overexpression was induced by transfection of a pcDNA3.1-Flag-RITA plasmid into HepG2 cells. RITA knockdown was achieved by siRNA transfection. mRNA and protein expression of target genes were quantified by qRT-PCR and Western blotting, respectively. Cell proliferation and apoptosis were measured using MTT assay and flow cytometry. Our results demonstrate that adjacent nontumoral liver samples exhibited increased RITA expression compared to HCC tissues (p RITA levels were associated with tumor differentiation status. Overexpression of RITA suppressed cell proliferation and promoted early apoptosis, while its silencing promoted cell growth dramatically (p RITA overexpression upregulated p53 and reduced cyclin E levels, whereas silencing of RITA had the opposite effect on p53 and cyclin E expression. Our in vitro results represent the first evidence that RITA might suppress tumor growth and induce apoptosis in HCCs, and may be a potent antitumoral agent for HCC treatment that deserves further exploration.

  12. Deficiency of RITA results in multiple mitotic defects by affecting microtubule dynamics.

    Science.gov (United States)

    Steinhäuser, K; Klöble, P; Kreis, N-N; Ritter, A; Friemel, A; Roth, S; Reichel, J M; Michaelis, J; Rieger, M A; Louwen, F; Oswald, F; Yuan, J

    2017-04-01

    Deregulation of mitotic microtubule (MT) dynamics results in defective spindle assembly and chromosome missegregation, leading further to chromosome instability, a hallmark of tumor cells. RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signaling pathway. Intriguingly, deregulated RITA is involved in primary hepatocellular carcinoma and other malignant entities. We were interested in the potential molecular mechanisms behind its involvement. We show here that RITA binds to tubulin and localizes to various mitotic MT structures. RITA coats MTs and affects their structures in vitro as well as in vivo. Tumor cell lines deficient of RITA display increased acetylated α-tubulin, enhanced MT stability and reduced MT dynamics, accompanied by multiple mitotic defects, including chromosome misalignment and segregation errors. Re-expression of wild-type RITA, but not RITA Δtub ineffectively binding to tubulin, restores the phenotypes, suggesting that the role of RITA in MT modulation is mediated via its interaction with tubulin. Mechanistically, RITA interacts with tubulin/histone deacetylase 6 (HDAC6) and its suppression decreases the binding of the deacetylase HDAC6 to tubulin/MTs. Furthermore, the mitotic defects and increased MT stability are also observed in RITA -/- mouse embryonic fibroblasts. RITA has thus a novel role in modulating MT dynamics and its deregulation results in erroneous chromosome segregation, one of the major reasons for chromosome instability in tumor cells.

  13. Habilidades académicas en estudiantes de nuevo ingreso a la Universidad del Zulia

    Directory of Open Access Journals (Sweden)

    Mariana Fernández Reina

    2015-01-01

    Full Text Available Al inicio de su carrera universitaria algunos jóvenes demuestran no poseer las habilidades académicas necesarias para alcanzar la culminación de sus estudios. Esta investigación se enfoca en diagnosticar las habilidades académicas de los estudiantes cuando ingresan a la universidad. Se plantea una investigación descriptiva, con un diseño transeccional, univariable, de campo, no experimental. La población de estudio estuvo conformada por 940 estudiantes que ingresaron al Núcleo Costa Oriental del Lago de la Universidad del Zulia en las carreras de Ingeniería, Ciencias Económicas y Sociales, y Educación, para el primer período de 2012. La muestra seleccionada fue no probabilística, conformada por 179 estudiantes. El instrumento empleado para la recolección de datos fue la escala de habilidades académicas en estudiantes universitarios, compuesta por 40 reactivos, tipo Likert, la cual alcanzó una confiabilidad alfa de Cronbach de 0,86. Según los resultados los estudiantes de nuevo ingreso poseen un nivel bajo de habilidades académicas (organización; empleo de técnicas; motivación, lo cual no les permite abordar con éxito los retos de la vida universitaria. Se sugiere reforzar las mismas a través de la práctica.

  14. Santa Rita Experimental Range digital database: user's guide

    Science.gov (United States)

    Mitchel P. McClaran; Deborah L. Angell; Craig Wissler

    2002-01-01

    Long-term measurements and repeat photograph collections have been collected in a systematic manner on the approximately 21,000 ha Santa Rita Experimental Range (SRER) since its establishment in 1903. This research facility, located in the Desert Grassland vegetation of southern Arizona, was administered by the U.S. Department of Agriculture until 1988, when it was...

  15. Swamp tours in Louisiana post Hurricane Katrina and Hurricane Rita

    Science.gov (United States)

    Dawn J. Schaffer; Craig A. Miller

    2007-01-01

    Hurricanes Katrina and Rita made landfall in southern Louisiana during August and September 2005. Prior to these storms, swamp tours were a growing sector of nature-based tourism that entertained visitors while teaching about local flora, fauna, and culture. This study determined post-hurricane operating status of tours, damage sustained, and repairs made. Differences...

  16. Sir John and Lady Rita Cornforth: a distinguished chemical partnership.

    Science.gov (United States)

    Purchase, Rupert; Hanson, James R

    2015-01-01

    This review describes the life of Sir John Cornforth AC CBE FRS, who was awarded the Nobel Prize for Chemistry in 1975. It covers his early life in Australia, his work in Oxford, the National Institute for Medical Research, the Milstead Laboratory of Chemical Enzymology and the University of Sussex, together with the contributions made by his wife, Lady Rita Cornforth.

  17. Resilience of Professional Counselors Following Hurricanes Katrina and Rita

    Science.gov (United States)

    Lambert, Simone F.; Lawson, Gerard

    2013-01-01

    Professional counselors who provided services to those affected by Hurricanes Katrina and Rita completed the K6+ (screen for severe mental illness), the Posttraumatic Growth Inventory, and the Professional Quality of Life Scale. Results indicated that participants who survived the hurricanes had higher levels of posttraumatic growth than…

  18. Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless.

    Science.gov (United States)

    Brockmann, Birgit; Mastel, Helena; Oswald, Franz; Maier, Dieter

    2014-12-01

    Notch signalling mediates intercellular communication, which is effected by the transcription factor CSL, an acronym for vertebrate CBF1/RBP-J, Drosophila Suppressor of Hairless [Su(H)] and C. elegans Lag1. Nuclear import of CBF1/RBP-J depends on co-activators and co-repressors, whereas the export relies on RITA. RITA is a tubulin and CBF1/RBP-J binding protein acting as a negative regulator of Notch signalling in vertebrates. RITA protein is highly conserved in eumatazoa, but no Drosophila homologue was yet identified. In this work, the activity of human RITA in the fly was addressed. To this end, we generated transgenic flies that allow a tissue specific induction of human RITA, which was demonstrated by Western blotting and in fly tissues. Unexpectedly, overexpression of RITA during fly development had little phenotypic consequences, even when overexpressed simultaneously with either Su(H) or the Notch antagonist Hairless. We demonstrate the in vivo binding of human RITA to Su(H) and to tubulin by co-immune precipitation. Moreover, RITA and tubulin co-localized to some degree in several Drosophila tissues. Overall our data show that human RITA, albeit binding to Drosophila Su(H) and tubulin, cannot influence the Notch signalling pathway in the fly, suggesting that a nuclear export mechanism of Su(H), if existent in Drosophila, does not depend on RITA. © 2015 The Authors.

  19. Surface ultrastructure of the gill filaments and the secondary lamellae of the catfish, Rita rita, and the carp, Cirrhinus mrigala.

    Science.gov (United States)

    Kumari, Usha; Mittal, Swati; Mittal, Ajay Kumar

    2012-04-01

    Surface ultrastructures of gill filaments and secondary lamellae of Rita rita and Cirrhinus mrigala, inhabiting different ecological habitat, were investigated to unravel adaptive modifications. R. rita is a sluggish, bottom dwelling carnivorous catfish, which inhabits regions of river with accumulations of dirty water. It retains its viability for long time if taken out of water. C. mrigala is an active bottom dwelling Indian major carp, which lives in relatively clean water and dies shortly after taken out of water. In R. rita, gill septa between gill filaments are reduced. Microridges on epithelial cells covering gill filaments are often continuous and arranged concentrically. Secondary lamellae are extensive. The epithelium appears corrugated, show irregular elevations and shallow depressions, and microridges on epithelial cells appear fragmented. In C. mrigala, in contrast, the gill septa are extensive. Microridges on epithelial cells covering gill filaments are fragmented. Secondary lamellae are less extensive. The epithelium appears smooth and microridges on epithelial cells are relatively inconspicuous. These differences have been considered adaptive modification in relation to habit and ecological niches inhabited by two fish species. Presence of mucous goblet cells on gill filaments is discussed in relation to their functions including precipitation of the sediments and preventing clogging of gill filaments. Infrequent mucous goblet cells in the epithelium of secondary lamellae in two fish species are considered an adaptation, minimizing thickness of the epithelium to reduce barrier between blood and water for favoring gasses exchange with increased efficiency. Copyright © 2011 Wiley-Liss, Inc.

  20. Serous goblet cells: the protein secreting cells in the oral cavity of a catfish, Rita rita (Hamilton, 1822) (Bagridae, Siluriformes).

    Science.gov (United States)

    Yashpal, Madhu; Mittal, Ajay Kumar

    2014-02-01

    Serous goblet cells in the oral epithelium of Rita rita are characterized by the presence of distinct eosinophilic granules occupying large parts of the cytoplasm. In R. rita, a range of histochemical results reveal that these cells are involved in proteinaceous secretions, and thus likely contribute to various functions analogous to those of mammalian saliva. The secretions of these cells have also been associated with specific functions and are discussed in relation to their physiological importance with special reference to their roles in lubrication, alteration in viscosity, various functions of mucus such as handling, maneuvering and driving of food items toward the esophagus, maintaining taste sensitivity and protection of the oral epithelium. In addition, the serous goblet cells may also be considered as the primary defensive cell of the oral epithelium of R. rita. The results significantly add to very limited set of literature on the serous goblet cells and provide noteworthy information on the mucous secretions in the oral cavity of fish. Copyright © 2013 Elsevier Ltd. All rights reserved.

  1. MONOPOLY AND OLIGOPOLY: CAUSES OF ENTERPRISES CLOSED IN VENEZUELA. A CASE STUDY IN THE ZULIA STATE.GROUP SIDEPRO.

    Directory of Open Access Journals (Sweden)

    Javier Agostini

    2011-04-01

    Full Text Available The economy has been impacted because of the monopoly and oligopoly Venezuela markets. This study analyzes the causes of the closure of the main company producing pipes for the oil industry in Zulia State.(Group SIDERPRO It is a research field, documentary and descriptive. The information was collected on experiences arising in the process of expropriation and recovery. As a result evidence of the need to propose a macroeconomic planning and control allowing to speed recovery of closed industrial parks and Venezuela recovery process model.

  2. Combined VLF and VHF lightning observations of Hurricane Rita landfall

    Science.gov (United States)

    Henderson, B. G.; Suszcynsky, D. M.; Wiens, K. C.; Hamlin, T.; Jeffery, C. A.; Orville, R. E.

    2009-12-01

    Hurricane Rita displayed abundant lightning in its northern eyewall as it made landfall at 0740 UTC 24 Sep 2005 near the Texas/Louisiana border. For this work, we combined VHF and VLF lightning data from Hurricane Rita, along with radar observations from Gulf Coast WSR-88D stations, for the purpose of demonstrating the combined utility of these two spectral regions for hurricane lightning monitoring. Lightning is a direct consequence of the electrification and breakdown processes that take place during the convective stages of thunderstorm development. As Rita approached the Gulf coast, the VHF lightning emissions were distinctly periodic with a period of 1.5 to 2 hours, which is consistent with the rotational period of hurricanes. VLF lightning emissions, measured by LASA and NLDN, were present in some of these VHF bursts but not all of them. At landfall, there was a significant increase in lightning emissions, accompanied by a significant convective surge observed in radar. Furthermore, VLF and VHF lightning source heights clearly increase as a function of time. The evolution of the IC/CG ratio is consistent with that seen in thunderstorms, showing a dominance of IC activity during storm development, followed by an increase in CG activity at the storm’s peak. The periodic VHF lightning events are correlated with increases in convective growth (quantified by the volume of radar echo >40 dB) above 7 km altitude. VLF can discriminate between lightning types, and in the LASA data, Rita landfall lightning activity was dominated by Narrow Bi-polar Events (NBEs)—high-energy, high-altitude, compact intra-cloud discharges. The opportunity to locate NBE lightning sources in altitude may be particularly useful in quantifying the vertical extent (strength) of the convective development and in possibly deducing vertical charge distributions.

  3. Lightning and radar observations of hurricane Rita landfall

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, Bradley G [Los Alamos National Laboratory; Suszcynsky, David M [Los Alamos National Laboratory; Hamlin, Timothy E [Los Alamos National Laboratory; Jeffery, C A [Los Alamos National Laboratory; Wiens, Kyle C [TEXAS TECH U.; Orville, R E [TEXAS A& M

    2009-01-01

    Los Alamos National Laboratory (LANL) owns and operates an array of Very-Low Frequency (VLF) sensors that measure the Radio-Frequency (RF) waveforms emitted by Cloud-to-Ground (CG) and InCloud (IC) lightning. This array, the Los Alamos Sferic Array (LASA), has approximately 15 sensors concentrated in the Great Plains and Florida, which detect electric field changes in a bandwidth from 200 Hz to 500 kHz (Smith et al., 2002). Recently, LANL has begun development of a new dual-band RF sensor array that includes the Very-High Frequency (VHF) band as well as the VLF. Whereas VLF lightning emissions can be used to deduce physical parameters such as lightning type and peak current, VHF emissions can be used to perform precise 3d mapping of individual radiation sources, which can number in the thousands for a typical CG flash. These new dual-band sensors will be used to monitor lightning activity in hurricanes in an effort to better predict intensification cycles. Although the new LANL dual-band array is not yet operational, we have begun initial work utilizing both VLF and VHF lightning data to monitor hurricane evolution. In this paper, we present the temporal evolution of Rita's landfall using VLF and VHF lightning data, and also WSR-88D radar. At landfall, Rita's northern eyewall experienced strong updrafts and significant lightning activity that appear to mark a transition between oceanic hurricane dynamics and continental thunderstorm dynamics. In section 2, we give a brief overview of Hurricane Rita, including its development as a hurricane and its lightning history. In the following section, we present WSR-88D data of Rita's landfall, including reflectivity images and temporal variation. In section 4, we present both VHF and VLF lightning data, overplotted on radar reflectivity images. Finally, we discuss our observations, including a comparison to previous studies and a brief conclusion.

  4. 75 FR 7467 - Gary E. Hall and Rita C. Hall; Notice of Application Accepted for Filing With the Commision...

    Science.gov (United States)

    2010-02-19

    ... Rita C. Hall; Notice of Application Accepted for Filing With the Commision, Soliciting Motions To.... Project No.: 13652-000. c. Date filed: January 11, 2010. d. Applicant: Gary E. Hall and Rita C. Hall. e... Policies Act of 1978, 16 U.S.C. 2705, 2708. h. Applicant Contact: Mr. Gary E. Hall and Ms. Rita C. Hall, P...

  5. RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems

    Directory of Open Access Journals (Sweden)

    Daiha Shin

    2017-10-01

    Condensed abstract: This study revealed a novel RITA resistant mechanism associated with the sustained induction of autophagy, p62 overexpression, and Keap1-Nrf2 antioxidant system activation. The combined treatment of RITA with the autophagy inhibitor 3-methyladenine overcomes RITA resistance via dual inhibition of autophagy and antioxidant systems in vitro and in vivo.

  6. The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells.

    Directory of Open Access Journals (Sweden)

    Hui-Ching Chuang

    Full Text Available TP53 is the most commonly mutated gene in head and neck cancer (HNSCC, with mutations being associated with resistance to conventional therapy. Restoring normal p53 function has previously been investigated via the use of RITA (reactivation of p53 and induction of tumor cell apoptosis, a small molecule that induces a conformational change in p53, leading to activation of its downstream targets. In the current study we found that RITA indeed exerts significant effects in HNSCC cells. However, in this model, we found that a significant outcome of RITA treatment was accelerated senescence. RITA-induced senescence in a variety of p53 backgrounds, including p53 null cells. Also, inhibition of p53 expression did not appear to significantly inhibit RITA-induced senescence. Thus, this phenomenon appears to be partially p53-independent. Additionally, RITA-induced senescence appears to be partially mediated by activation of the DNA damage response and SIRT1 (Silent information regulator T1 inhibition, with a synergistic effect seen by combining either ionizing radiation or SIRT1 inhibition with RITA treatment. These data point toward a novel mechanism of RITA function as well as hint to its possible therapeutic benefit in HNSCC.

  7. How Schools Responded to Student Mental Health Needs Following Hurricanes Katrina and Rita. Fact Sheet

    Science.gov (United States)

    RAND Corporation, 2007

    2007-01-01

    This fact sheet summarizes a study that examined how schools in the U.S. Gulf Coast region perceived the mental health needs of students after Hurricanes Katrina and Rita and how schools responded. According to the report, despite strong initial efforts to support the mental health needs of students displaced by Hurricanes Katrina and Rita, many…

  8. The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells.

    Science.gov (United States)

    Chuang, Hui-Ching; Yang, Liang Peng; Fitzgerald, Alison L; Osman, Abdullah; Woo, Sang Hyeok; Myers, Jeffrey N; Skinner, Heath D

    2014-01-01

    TP53 is the most commonly mutated gene in head and neck cancer (HNSCC), with mutations being associated with resistance to conventional therapy. Restoring normal p53 function has previously been investigated via the use of RITA (reactivation of p53 and induction of tumor cell apoptosis), a small molecule that induces a conformational change in p53, leading to activation of its downstream targets. In the current study we found that RITA indeed exerts significant effects in HNSCC cells. However, in this model, we found that a significant outcome of RITA treatment was accelerated senescence. RITA-induced senescence in a variety of p53 backgrounds, including p53 null cells. Also, inhibition of p53 expression did not appear to significantly inhibit RITA-induced senescence. Thus, this phenomenon appears to be partially p53-independent. Additionally, RITA-induced senescence appears to be partially mediated by activation of the DNA damage response and SIRT1 (Silent information regulator T1) inhibition, with a synergistic effect seen by combining either ionizing radiation or SIRT1 inhibition with RITA treatment. These data point toward a novel mechanism of RITA function as well as hint to its possible therapeutic benefit in HNSCC.

  9. Te Rita Papesch: Case Study of an Exemplary Learner of Maori as an Additional Language

    Science.gov (United States)

    Ratima, Matiu Tai; Papesch, Te Rita

    2014-01-01

    This paper presents a case study of the life experiences of one exemplar adult second language Maori learner--Te Rita Papesch. Te Rita was one of 17 participants who were interviewed as a part of the first author's PhD study which sought to answer the question: what factors lead to the development of proficiency in te reo Maori amongst adult…

  10. 75 FR 14442 - Federal Travel Regulation (FTR); Relocation Allowances-Relocation Income Tax Allowance (RITA) Tables

    Science.gov (United States)

    2010-03-25

    ... GENERAL SERVICES ADMINISTRATION [GSA Bulletin FTR 10-04] Federal Travel Regulation (FTR); Relocation Allowances-- Relocation Income Tax Allowance (RITA) Tables AGENCY: Office of Governmentwide Policy... (73 FR 35952) specifying that GSA would no longer publish the RITA tables found in 41 CFR Part 301-17...

  11. METODOLOGÍA PARA PRÁCTICAS EN LABORATORIOS DE DISEÑO MECÁNICO. UNA EXPERIENCIA DOCENTE EN LA UNIVERSIDAD DEL ZULIA (METHODOLOGY FOR PRACTICES IN LABORATORIES OF MECHANICAL DESIGN. AN EDUCATIONAL EXPERIENCE IN THE UNIVERSITY OF ZULIA

    Directory of Open Access Journals (Sweden)

    Alvarado Yajaira

    2011-04-01

    Full Text Available Resumen:El presente artículo tiene como objetivo determinar los parámetros fundamentales que generen una metodología pertinente para la inserción de las prácticas en el laboratorio técnico de diseño mecánico de la Universidad del Zulia Núcleo Costa Oriental del Lago. El estudio es descriptivo transeccional con un diseño de campo no experimental. El instrumento de recolección de datos fue el cuestionario. La población estuvo conformada por 10 profesores que administran académicamente las unidades curriculares adscritas en el área de diseño mecánico. Por ser una población finita se empleó el censo poblacional. Los resultados determinaron la necesidad de diseñar una serie de prácticas relacionadas con: Mecánica de Sólidos, Elementos de Máquinas, Dinámica, Estática y Mecánica de Máquinas, con lo cual exista una conexión entre lo establecido en el plan curricular de La Universidad del Zulia (LUZ y el proyecto del laboratorio técnico del Núcleo; de tal forma que el estudiante sea preparado como un individuo integral, capaz de desenvolverse dentro de una sociedad del conocimiento enmarcada en el fenómeno de la globalización, en pro de una formación integral ajustada al desarrollo de competencias especificas como lo establece la nueva resolución del Ministerio de Educación Superior de Venezuela, a fin de que el egresado se relacione, directamente, con el sector productivo.Abstract: This article aims to determine the basic parameters to generate an appropriate methodology for the integration of technical laboratory practices in the mechanical design of the Universidad Del Zulia Núcleo Costa Oriental del Lago. The study is descriptive trans with a non-experimental field design. The data collection instrument was the questionnaire. The population consisted of 10 teachers who manage academic curriculum units assigned in the area of mechanical design. As a finite population census was used. The results determined the need

  12. RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.

    Science.gov (United States)

    Gottlieb, Aline; Althoff, Kristina; Grunewald, Laura; Thor, Theresa; Odersky, Andrea; Schulte, Marc; Deubzer, Hedwig E; Heukamp, Lukas; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes H; Künkele, Annette

    2017-04-25

    Current therapy of medulloblastoma, the most common malignant brain tumor of childhood, achieves 40-70% survival. Secondary chemotherapy resistance contributes to treatment failure, where TP53 pathway dysfunction plays a key role. MDM2 interaction with TP53 leads to its degradation. Reactivating TP53 functionality using small-molecule inhibitors, such as RITA, to disrupt TP53-MDM2 binding may have therapeutic potential. We show here that RITA decreased viability of all 4 analyzed medulloblastoma cell lines, regardless of TP53 functional status. The decrease in cell viability was accompanied in 3 of the 4 medulloblastoma cell lines by accumulation of TP53 protein in the cells and increased CDKN1A expression. RITA treatment in mouse models inhibited medulloblastoma xenograft tumor growth. These data demonstrate that RITA treatment reduces medulloblastoma cell viability in both in vitro and in vivo models, and acts independently of cellular TP53 status, identifying RITA as a potential therapeutic agent to treat medulloblastoma.

  13. Conversacion sobre "Tres tristes tigres". Una entrevista de Rita Guibert (A Conversation about "Three Sad Tigers". An Interview with Rita Guibert)

    Science.gov (United States)

    Cabrera Infante, Guillermo

    1971-01-01

    Interview took place in London, England, on October 5, 1970 between Cuban writer Guillermo Cabrera Infante and journalist Rita Guibert. Special issue dedicated to contemporary Spanish American literature. (DS)

  14. Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin.

    Science.gov (United States)

    Wiegering, Armin; Matthes, Niels; Mühling, Bettina; Koospal, Monika; Quenzer, Anne; Peter, Stephanie; Germer, Christoph-Thomas; Linnebacher, Michael; Otto, Christoph

    2017-04-01

    Colorectal carcinoma (CRC) is the most common cancer of the gastrointestinal tract with frequently dysregulated intracellular signaling pathways, including p53 signaling. The mainstay of chemotherapy treatment of CRC is 5-fluorouracil (5FU) and oxaliplatin. The two anticancer drugs mediate their therapeutic effect via DNA damage-triggered signaling. The small molecule reactivating p53 and inducing tumor apoptosis (RITA) is described as an activator of wild-type and reactivator of mutant p53 function, resulting in elevated levels of p53 protein, cell growth arrest, and cell death. Additionally, it has been shown that RITA can induce DNA damage signaling. It is expected that the therapeutic benefits of 5FU and oxaliplatin can be increased by enhancing DNA damage signaling pathways. Therefore, we highlighted the antiproliferative response of RITA alone and in combination with 5FU or oxaliplatin in human CRC cells. A panel of long-term established CRC cell lines (n=9) including p53 wild-type, p53 mutant, and p53 null and primary patient-derived, low-passage cell lines (n=5) with different p53 protein status were used for this study. A substantial number of CRC cells with pronounced sensitivity to RITA (IC 50 RITA appeared independent of p53 status and was associated with an increase in antiproliferative response to 5FU and oxaliplatin, a transcriptional increase of p53 targets p21 and NOXA, and a decrease in MYC mRNA. The effect of RITA as an inducer of DNA damage was shown by a strong elevation of phosphorylated histone variant H2A.X, which was restricted to RITA-sensitive cells. Our data underline the primary effect of RITA, inducing DNA damage, and demonstrate the differential antiproliferative effect of RITA to CRC cells independent of p53 protein status. We found a substantial number of RITA-sensitive CRC cells within both panels of established CRC cell lines and primary patient-derived CRC cell lines (6/14) that provide a rationale for combining RITA with 5FU or

  15. Reactivating p53 and Inducing Tumor Apoptosis (RITA Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin

    Directory of Open Access Journals (Sweden)

    Armin Wiegering

    2017-04-01

    Full Text Available Colorectal carcinoma (CRC is the most common cancer of the gastrointestinal tract with frequently dysregulated intracellular signaling pathways, including p53 signaling. The mainstay of chemotherapy treatment of CRC is 5-fluorouracil (5FU and oxaliplatin. The two anticancer drugs mediate their therapeutic effect via DNA damage-triggered signaling. The small molecule reactivating p53 and inducing tumor apoptosis (RITA is described as an activator of wild-type and reactivator of mutant p53 function, resulting in elevated levels of p53 protein, cell growth arrest, and cell death. Additionally, it has been shown that RITA can induce DNA damage signaling. It is expected that the therapeutic benefits of 5FU and oxaliplatin can be increased by enhancing DNA damage signaling pathways. Therefore, we highlighted the antiproliferative response of RITA alone and in combination with 5FU or oxaliplatin in human CRC cells. A panel of long-term established CRC cell lines (n = 9 including p53 wild-type, p53 mutant, and p53 null and primary patient-derived, low-passage cell lines (n = 5 with different p53 protein status were used for this study. A substantial number of CRC cells with pronounced sensitivity to RITA (IC50< 3.0 μmol/l were identified within established (4/9 and primary patient-derived (2/5 CRC cell lines harboring wild-type or mutant p53 protein. Sensitivity to RITA appeared independent of p53 status and was associated with an increase in antiproliferative response to 5FU and oxaliplatin, a transcriptional increase of p53 targets p21 and NOXA, and a decrease in MYC mRNA. The effect of RITA as an inducer of DNA damage was shown by a strong elevation of phosphorylated histone variant H2A.X, which was restricted to RITA-sensitive cells. Our data underline the primary effect of RITA, inducing DNA damage, and demonstrate the differential antiproliferative effect of RITA to CRC cells independent of p53 protein status. We found a substantial number

  16. The presence of communication in the basic organizational principles of the University of Zulia towards the student sector

    Directory of Open Access Journals (Sweden)

    Laura Castellano Ramírez

    2006-11-01

    Full Text Available This article is centered in detecting the presence of comunication towards the student sector, like a formal element in the redaccion of the organization basic principles (OBP of La Universidad del Zulia, such as Mision, Vision, Values, Polítics, Objectives and Strategies. Starting from the theoric approach of that the OBP conform the basic component of the Corporative Identity, in wish are rised the other three: the organizational beheivier, the simbology or visual identity and the comunication. Through the documentary research it has concluded that the communication towards the student community is not taken in count in the redaction of the basic principles, it is mentioned only in the comunicational politic but in a very general way.

  17. Shelf sediment transport during hurricanes Katrina and Rita

    Science.gov (United States)

    Xu, Kehui; Mickey, Rangley C.; Chen, Qin; Harris, Courtney K.; Hetland, Robert D.; Hu, Kelin; Wang, Jiaze

    2016-05-01

    Hurricanes can greatly modify the sedimentary record, but our coastal scientific community has rather limited capability to predict hurricane-induced sediment deposition. A three-dimensional sediment transport model was developed in the Regional Ocean Modeling System (ROMS) to study seabed erosion and deposition on the Louisiana shelf in response to Hurricanes Katrina and Rita in the year 2005. Sensitivity tests were performed on both erosional and depositional processes for a wide range of erosional rates and settling velocities, and uncertainty analysis was done on critical shear stresses using the polynomial chaos approximation method. A total of 22 model runs were performed in sensitivity and uncertainty tests. Estimated maximum erosional depths were sensitive to the inputs, but horizontal erosional patterns seemed to be controlled mainly by hurricane tracks, wave-current combined shear stresses, seabed grain sizes, and shelf bathymetry. During the passage of two hurricanes, local resuspension and deposition dominated the sediment transport mechanisms. Hurricane Katrina followed a shelf-perpendicular track before making landfall and its energy dissipated rapidly within about 48 h along the eastern Louisiana coast. In contrast, Hurricane Rita followed a more shelf-oblique track and disturbed the seabed extensively during its 84-h passage from the Alabama-Mississippi border to the Louisiana-Texas border. Conditions to either side of Hurricane Rita's storm track differed substantially, with the region to the east having stronger winds, taller waves and thus deeper erosions. This study indicated that major hurricanes can disturb the shelf at centimeter to meter levels. Each of these two hurricanes suspended seabed sediment mass that far exceeded the annual sediment inputs from the Mississippi and Atchafalaya Rivers, but the net transport from shelves to estuaries is yet to be determined. Future studies should focus on the modeling of sediment exchange between

  18. Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy.

    Science.gov (United States)

    Rödel, Franz; Steinhäuser, Kerstin; Kreis, Nina-Naomi; Friemel, Alexandra; Martin, Daniel; Wieland, Ulrike; Rave-Fränk, Margret; Balermpas, Panagiotis; Fokas, Emmanouil; Louwen, Frank; Rödel, Claus; Yuan, Juping

    2018-02-01

    RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signalling pathway and its deregulation is involved in the pathogenesis of several tumour entities. RITA's impact on the response of anal squamous cell carcinoma (SCC) to anticancer treatment, however, remains elusive. In our retrospective study immunohistochemical evaluation of RITA was performed on 140 pre-treatment specimens and was correlated with clinical and histopathologic characteristics and clinical endpoints cumulative incidence of local control (LC), distant recurrence (DC), disease-free survival (DFS) and overall survival (OS). We observed significant inverse correlations between RITA expression and tumour grading, the levels of HPV-16 virus DNA load, CD8 (+) tumour infiltrating lymphocytes and programmed death protein (PD-1) immunostaining. In univariate analyses, elevated levels of RITA expression were predictive for decreased local control (p = 0.001), decreased distant control (p = 0.040), decreased disease free survival (p = 0.001) and overall survival (p RITA expression remained significant for decreased local control (p = 0.009), disease free survival (p = 0.032) and overall survival (p = 0.012). These data indicate that elevated levels of pretreatment RITA expression are correlated with unfavourable clinical outcome in anal carcinoma treated with concomitant chemoradiotherapy. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. [RITA combined with temozolomide inhibits the proliferation of human glioblastoma U87 cells].

    Science.gov (United States)

    He, Xiao-Yan; Feng, Xiao-Li; Song, Xin-Pei; Zeng, Huan-Chao; Cao, Zhong-Xu; Xiao, Wei-Wei; Zhang, Bao; Wu, Qing-Hua

    2016-10-20

    To observe the effect of RITA, a small molecule that targets p53, combined with temozolomide (TMZ) on proliferation, colony formation and apoptosis of human glioblastoma U87 cells and explore the underlying mechanism. Cultured U87 cells were treated with RITA (1, 5, 10, 20 µmol/L), TMZ, or RITA+TMZ (half dose) for 24, 48 or 72 h. MTS assay were used to detect the cell proliferation, and the cell proliferation rate and inhibitory rate were calculated. The effect of combined treatments was evaluated by the q value. The expressions of p53, p21 and other apoptosis-associated genes were detected by qRT-PCR and Western blotting; cell apoptosis was assayed using flow cytometry with Annexin V/PI double staining; colony formation of the cells was detected with crystal violet staining. MTS assay showed that RITA at the 4 doses more potently inhibited U87 cell viability than TMZ at 72 h (P=0.000) with inhibitory rates of 25.94%-41.38% and 3.84%-8.20%, respectively. RITA combined with TMZ caused a more significant inhibition of U87 cells (29.21%-52.11%) than RITA (PRITA+TMZ for 48 h resulted in q values exceeding 1.2 and showed an obvious synergistic effect of the drugs. Both RITA and TMZ, especially the latter, significantly increased the expressions of p53, p21, puma, and other apoptosis-associated genes to accelerate apoptosis and inhibit the growth and colony formation of U87 cells, and the effect was more obvious with a combined treatment. RITA inhibits the growth of human glioblastoma cells and enhance their sensitivity to TMZ by up-regulating p53 expression, and when combined, RITA and TMZ show a synergistic effect to cause a stronger cell inhibition.

  20. A Green Prison: The Santa Rita Jail Campus Microgrid

    Energy Technology Data Exchange (ETDEWEB)

    Marnay, Chris; DeForest, Nicholas; Lai, Judy

    2012-01-22

    A large microgrid project is nearing completion at Alameda County’s twenty-two-year-old 45 ha 4,000-inmate Santa Rita Jail, about 70 km east of San Francisco. Often described as a green prison, it has a considerable installed base of distributed energy resources (DER) including an eight-year old 1.2 MW PV array, a five-year old 1 MW fuel cell with heat recovery, and considerable efficiency investments. A current US$14 M expansion adds a 2 MW-4 MWh Li-ion battery, a static disconnect switch, and various controls upgrades. During grid blackouts, or when conditions favor it, the Jail can now disconnect from the grid and operate as an island, using the on-site resources described together with its back-up diesel generators. In other words, the Santa Rita Jail is a true microgrid, or μgrid, because it fills both requirements, i.e. it is a locally controlled system, and it can operate both grid connected and islanded. The battery’s electronics includes Consortium for Electric Reliability Technology (CERTS) Microgrid technology. This enables the battery to maintain energy balance using droops without need for a fast control system.

  1. Integration& Operation of a Microgrid at Santa Rita Jail

    Energy Technology Data Exchange (ETDEWEB)

    Chevron Energy Solutions; Alameda County; DeForest, Nicholas; Lai, Judy; Stadler, Michael; Mendes, Goncalo; Marnay, Chris; Donadee, Jon

    2011-05-01

    Santa Rita Jail is a 4,500 inmate facility located in Dublin CA, approximately 40 miles (65 km) east of San Francisco. Over the past decade, a series of Distributed Energy Resources (DER) installations and efficiency measures have been undertaken to transform the 3MW facility into a"Green Jail". These include a 1.2MW rated rooftop PV system installed in 2002, a 1MW molten carbonate fuel cell with CHP, and retrofits to lighting and HVAC systems to reduce peak loads. With the upcoming installation of a large-scale battery and fast static disconnect switch, Santa Rita Jail will become a true microgrid, with full CERTS Microgrid functionality. Consequently, the jail will be able to seamlessly disconnect from the grid and operate as an island in the event of a disturbance, reconnecting again once the disturbance has dissipated. The extent to which that jail is capable of islanding is principally dependant on the energy capacity of the battery-one focus of this investigation. Also presented here are overviews of the DER currently installed at the jail, as well as the value it provides by offsetting the purchase of electricity under the current Pacific Gas& Electric (PG&E) tariff.

  2. Land Area Change and Fractional Water Maps in the Chenier Plain, Louisiana, following Hurricane Rita (2005)

    Science.gov (United States)

    Palaseanu-Lovejoy, Monica; Kranenburg, Christine J.; Brock, John C.

    2010-01-01

    In this study, we estimated the changes in land and water coverage of a 1,961-square-kilometer (km2) area in Louisiana's Chenier Plain. The study area is roughly centered on the Sabine National Wildlife Refuge, which was impacted by Hurricane Rita on September 24, 2005. The objective of this study is twofold: (1) to provide pre- and post-Hurricane Rita moderate-resolution (30-meter (m)) fractional water maps based upon multiple source images, and (2) to quantify land and water coverage changes due to Hurricane Rita.

  3. Positional stabilization of communications satellites - The RITA ion propulsion system is ready for commercial use

    Science.gov (United States)

    The radiofrequency ion thruster assembly (RITA) intended for service aboard the new Artemis communications satellite will operate for three hours twice a day, in order to furnish orbital position adjustments that keep antennas accurately pointed toward the earth. These engines are, despite such frequent and sustained use, projected to eject no more than 30 kG of Xe over the course of a decade. RITA operation is also extremely reliable and, due to its very low propellant consumption, is the basis of a long satellite service life. RITA will be among the 15 experiments that are to be performed by ESA's Eureca research satellite.

  4. Reflection on Lessons Learned: An Analysis of the Adverse Outcomes Observed During the Hurricane Rita Evacuation.

    Science.gov (United States)

    Baker, Karen

    2018-02-01

    In September 2005, nearly 3.7 million people evacuated the Texas coastline in advance of Hurricane Rita's landfall, making the event the largest emergency evacuation in US history. The Rita evacuation underscored the importance of planning for domestic mass-evacuation events, as the evacuation itself led to over 100 of the at least 119 deaths attributed to the storm. In the days preceding Rita's landfall, several cascading, interrelated circumstances precipitated such adverse outcomes. This article explores the series of events leading up to the evacuation's poor outcomes, the response following Rita to amend evacuation plans, and how Texas successfully implemented these changes during later storms to achieve better outcomes. (Disaster Med Public Health Preparedness. 2018;12:115-120).

  5. Mold exposure and health effects following hurricanes Katrina and Rita.

    Science.gov (United States)

    Barbeau, Deborah N; Grimsley, L Faye; White, LuAnn E; El-Dahr, Jane M; Lichtveld, Maureen

    2010-01-01

    The extensive flooding in the aftermath of Hurricanes Katrina and Rita created conditions ideal for indoor mold growth, raising concerns about the possible adverse health effects associated with indoor mold exposure. Studies evaluating the levels of indoor and outdoor molds in the months following the hurricanes found high levels of mold growth. Homes with greater flood damage, especially those with >3 feet of indoor flooding, demonstrated higher levels of mold growth compared with homes with little or no flooding. Water intrusion due to roof damage was also associated with mold growth. However, no increase in the occurrence of adverse health outcomes has been observed in published reports to date. This article considers reasons why studies of mold exposure after the hurricane do not show a greater health impact.

  6. Transformative experiences for Hurricanes Katrina and Rita disaster volunteers.

    Science.gov (United States)

    Clukey, Lory

    2010-07-01

    The massive destruction caused by Hurricanes Katrina and Rita in 2005 provided an opportunity for many volunteers to be involved with disaster relief work. Exposure to devastation and personal trauma can have long-lasting and sometimes detrimental effects on people providing help. This qualitative study explored the experience of volunteer relief workers who provided disaster relief services after the hurricanes. Three major themes emerged: emotional reactions that included feelings of shock, fatigue, anger and grief as well as sleep disturbances; frustration with leadership; and life-changing personal transformation. Stress reactions were noted but appeared to be mitigated by feelings of compassion for the victims and personal satisfaction in being able to provide assistance. Suggestions are provided for further research.

  7. Stratigraphy of the Charqueadas Carboniferous basin, Santa Rita, RS, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Mendes Piccoli, A.E.; Holz, M.; Munaro, P.

    1985-01-01

    Sedimentological analyses of about 80 drill cores from the Charqueadas - Santa Rita Coal Field, west of Porto Alegre, Rio Grande do Sul State, were made. The Itarare Group is characterized by pelites of lacustrine origin and conglomerates and sandstones of alluvial fans, mainly in the north western region. A shallow lacustrine and paludal system characterize the Rio Bonito Formation, comprising coal seams and associated pelitic sediments, as well as some paraconglomerates and sandstone layers. The contact between these units is established by the colour of the pelites, differences in sedimentary textures, structures and palynological data. A marine transgression caused the sediments of the Rio Bonito Formation to be covered by coastal sandstones and pelites of the Palermo Formation, of tidal flat origin. Today, the coal layers and sediments have been eroded southward and slope gently to the north of the area.

  8. Katrina and Rita were lit up with lightning

    Science.gov (United States)

    Shao, X.-M.; Harlin, J.; Stock, M.; Stanley, M.; Regan, A.; Wiens, K.; Hamlin, T.; Pongratz, M.; Suszcynsky, D.; Light, T.

    Hurricanes generally produce very little lightning activity compared to other noncyclonic storms, and lightning is especially sparse in the eye wall and inner regions within tens of kilometers surrounding the eye [Molinari et al., 1994, 1999]. (The eye wall is the wall of clouds that encircles the eye of the hurricane.) Lightning can sometimes be detected in the outer, spiral rainbands, but the lightning occurrence rate varies significantly from hurricane to hurricane as well as within an individual hurricane's lifetime.Hurricanes Katrina and Rita hit the U.S. Gulf coasts of Louisiana, Mississippi, and Texas, and their distinctions were not just limited to their tremendous intensity and damage caused. They also differed from typical hurricanes in their lightning production rate.

  9. RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.

    Science.gov (United States)

    Wacker, Stephan Armin; Alvarado, Cristobal; von Wichert, Götz; Knippschild, Uwe; Wiedenmann, Jörg; Clauss, Karen; Nienhaus, Gerd Ulrich; Hameister, Horst; Baumann, Bernd; Borggrefe, Tilman; Knöchel, Walter; Oswald, Franz

    2011-01-05

    The evolutionarily conserved Notch signal transduction pathway regulates fundamental cellular processes during embryonic development and in the adult. Ligand binding induces presenilin-dependent cleavage of the receptor and a subsequent nuclear translocation of the Notch intracellular domain (NICD). In the nucleus, NICD binds to the recombination signal sequence-binding protein J (RBP-J)/CBF-1 transcription factor to induce expression of Notch target genes. Here, we report the identification and functional characterization of RBP-J interacting and tubulin associated (RITA) (C12ORF52) as a novel RBP-J/CBF-1-interacting protein. RITA is a highly conserved 36 kDa protein that, most interestingly, binds to tubulin in the cytoplasm and shuttles rapidly between cytoplasm and nucleus. This shuttling RITA exports RBP-J/CBF-1 from the nucleus. Functionally, we show that RITA can reverse a Notch-induced loss of primary neurogenesis in Xenopus laevis. Furthermore, RITA is able to downregulate Notch-mediated transcription. Thus, we propose that RITA acts as a negative modulator of the Notch signalling pathway, controlling the level of nuclear RBP-J/CBF-1, where its amounts are limiting.

  10. IGF-1R/MDM2 relationship confers enhanced sensitivity to RITA in Ewing sarcoma cells.

    Science.gov (United States)

    Di Conza, Giusy; Buttarelli, Marianna; Monti, Olimpia; Pellegrino, Marsha; Mancini, Francesca; Pontecorvi, Alfredo; Scotlandi, Katia; Moretti, Fabiola

    2012-06-01

    Ewing sarcoma is one of the most frequent bone cancers in adolescence. Although multidisciplinary therapy has improved the survival rate for localized tumors, a critical step is the development of new drugs to improve the long-term outcome of recurrent and metastatic disease and to reduce side effects of conventional therapy. Here, we show that the small molecule reactivation of p53 and induction of tumor cell apoptosis (RITA, NSC652287) is highly effective in reducing growth and tumorigenic potential of Ewing sarcoma cell lines. These effects occur both in the presence of wt-p53 as well as of mutant or truncated forms of p53, or in its absence, suggesting the presence of additional targets in this tumor histotype. Further experiments provided evidence that RITA modulates an important oncogenic mark of these cell lines, insulin-like growth factor receptor 1 (IGF-1R). Particularly, RITA causes downregulation of IGF-1R protein levels. MDM2 degradative activity is involved in this phenomenon. Indeed, inhibition of MDM2 function by genetic or pharmacologic approaches reduces RITA sensitivity of Ewing sarcoma cell lines. Overall, these data suggest that in the cell context of Ewing sarcoma, RITA may adopt additional mechanism of action besides targeting p53, expanding its field of application. Noteworthy, these results envisage the promising utilization of RITA or its derivative as a potential treatment for Ewing sarcomas. ©2012 AACR

  11. Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA.

    Science.gov (United States)

    Zhao, Carolyn Y; Grinkevich, Vera V; Nikulenkov, Fedor; Bao, Wenjie; Selivanova, Galina

    2010-05-01

    Expression of mutant p53 correlates with poor prognosis in many tumors, therefore strategies aimed at reactivation of mutant p53 are likely to provide important benefits for treatment of tumors that are resistant to chemotherapy and radiotherapy. We have previously identified and characterized a small molecule RITA which binds p53 and induces a conformational change which prevents the binding of p53 to several inhibitors, including its own destructor MDM2. In this way, RITA rescues the tumor suppression function of wild type p53. Here, we demonstrate that RITA suppressed the growth and induced apoptosis in human tumor cell lines of a diverse origin carrying mutant p53 proteins. RITA restored transcriptional transactivation and transrepression function of several hot spot p53 mutants. The ability of RITA to rescue the activity of different p53 mutants suggests its generic mechanism of action. Thus, RITA is a promising lead for the development of anti-cancer drugs that reactivate the tumor suppressor function of p53 in cancer cells irrespective whether they express mutant or wild type p53.

  12. A new perspective on autism: Rita Leal School

    Directory of Open Access Journals (Sweden)

    Rodrigues T. F.

    2016-12-01

    Full Text Available Guided by the principle that scientific knowledge should serve to transform reality and create suitable conditions of life for all, the Portuguese Association for Relational-Historical Psychology (APPRH founded a school named RITA LEAL (RLS, with a therapeutic purpose based on new perspectives for treating autism — perspectives quite different from instrumental and behavioral learning programs. The Rita Leal School (Leal, 1975/2004, 1997, 2005, 2010 is rooted in the theory that mental development is based on a mutually contingent emotional relationship, while it underwrites Vygotsky’s concept of the Zone of Proximal Development (ZPD and Mediation (1930/2004, 1934/2009. Learning to read is a complex process which individuals with Autism Spectrum Disorder (ASD master slowly and with difficulty. We analyzed the process of learning to read of two ASD children accompanied by peers without special educational needs, aiming to pinpoint distinct aspects of their progress. We used the Observer Software Program to collect and analyze observations of their performance, which were understood as data to be classified according to previously specified codes. We believed we could demonstrate that, especially in the case of ASD children, learning is dependent on contingent responses and adequate levels of mediation. The technical team at the RLS has continuous clinical supervision. That is because we believe this supervision is what permits the team to undergo a process of de-centering, becoming more empathic and accessible to the autists. This makes the team’s intervention more efficient, because it becomes more aware of each autist’s individual characteristics, and therefore more available to respond to the autist’s needs.

  13. Impact of hurricanes katrina and rita on the anesthesiology workforce.

    Science.gov (United States)

    Hutson, Larry R; Vega, Jorge; Schubert, Armin

    2011-01-01

    Hurricanes Katrina and Rita impacted a large portion of the medical community in Louisiana. We attempt to determine their impact on the anesthesiology workforce in Louisiana. In May 2006, a survey was mailed to 368 Louisiana anesthesiologists, collecting demographic data, retirement plans, impact of Hurricanes Katrina and Rita, position vacancies, practice conditions, and the general state of healthcare in their area. All 3 anesthesiology residency programs in the state were contacted regarding their recent graduates. The 2010 RAND survey of the anesthesiology workforce was reviewed with respect to findings relevant to the state and region. One hundred seventy surveys were returned, yielding a 46.2% response rate. Among the respondents, 13.9% intended to retire within 5 years and another 24% in 5 to 10 years. Since 2005, 63.9% had seen an increase in their daily caseload, 46.9% saw an increase in work hours, and 36.8% stated that their practices were trying to hire new anesthesiologists and were having difficulty filling these positions. Since 2005, the number of anesthesiology residents in Louisiana had declined by almost 50%, and the number of graduates remaining to practice in Louisiana had decreased by 43% from 7 to 4 annually. Our 2006 survey provided qualitative evidence for a shortage of anesthesiologists in the state of Louisiana after the natural disasters in 2005 that was likely to worsen as residency output plummeted, fewer residents stayed in the state, and projected retirement increased. The regional data from the RAND survey a year later confirmed the impressions from our survey, with an estimate of an anesthesiologist shortage as high as 39% of the workforce. State membership surveys may serve as accurate barometers in the wake of major environmental upheavals affecting regional anesthesiology workforce conditions.

  14. Resistência de Biomphalaria peregrina de Santa Rita do Sapucaí, Minas Gerais, a infecção com três cepas de Schistosoma mansoni Resistance of Biomphalaria peregrina from Santa Rita do Sapucaí, State of Minas Gerais, Brazil, to infection with strain of Schistosoma mansoni

    Directory of Open Access Journals (Sweden)

    Cecília Pereira de Souza

    1988-12-01

    Full Text Available Descendentes do planorbídeo Biomphalaria peregrina, coletados em Santa Rita do Sapucaí, Minas Gerais, Brasil, foram expostos a miracídios de três cepas de Schistosoma mansoni: "LE" de Belo Horizonte, MG; "SJ" de São José dos Campos, SP e "AL" do Estado de Alagoas. Dentre 300 exemplares expostos, nenhum se infectou com as três cepas do trematódeo. Por outro lado, 300 exemplares de B. glabrata, dos grupos de controle, apresentaram taxas de infecção de 61,1 a 95,3% com as três cepas do trematódeo. As taxas de mortalidade de B. peregrina e de B. glabrata foram de 20,0 e de 28,0%, respectivamente.The descendants of the planorbid snail Biomphalaria peregrina, collected in the region of Santa rita do Sapucaí, Minas Gerais, Brazil, were exposed to miracidia of three strains of Schistosoma mansoni: "LE" strain from Belo Horizonte, State of Minas Gerais; "SJ", strain from São José dos Campos, State of São Paulo and "AL" strain from State of Alagoas. Of 300 snails exposed to miracidia of the three strains, none was infected. On the other hand, 300 Biomphalaria glabrata of the control groups showed infection rates of 61.1 to 95.3% with three strains. The mortality rates of B. peregrina and B. glabrata were 20% and 28%, respectively.

  15. RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems.

    Science.gov (United States)

    Shin, Daiha; Kim, Eun Hye; Lee, Jaewang; Roh, Jong-Lyel

    2017-10-01

    Reactivation of p53 and induction of tumor cell apoptosis (RITA) is a small molecule that blocks p53-MDM2 interaction, thereby reactivating p53 in tumors. RITA can induce exclusive apoptosis in cancer cells independently of the p53 pathway; however, the resistance of cancer cells remains a major drawback. Here, we found a novel resistance mechanism of RITA treatment and an effective combined treatment to overcome RITA resistance in head and neck cancer (HNC) cells. The effects of RITA and 3-methyladenine (3-MA) were tested in different HNC cell lines, including cisplatin-resistant and acquired RITA-resistant HNC cells. The effects of each drug alone and in combination were assessed by measuring cell viability, apoptosis, cell cycle, glutathione, reactive oxygen species, protein expression, genetic inhibition of p62 and Nrf2, and a mouse xenograft model of cisplatin-resistant HNC. RITA induced apoptosis of HNC cells at different levels without significantly inhibiting normal cell viability. Following RITA treatment, RITA-resistant HNC cells exhibited a sustained expression of other autophagy-related proteins, overexpressed p62, and displayed activation of the Keap1-Nrf2 antioxidant pathway. The autophagy inhibitor 3-MA sensitized resistant HNC cells to RITA treatment via the dual inhibition of molecules related to the autophagy and antioxidant systems. Silencing of the p62 gene augmented the combined effects. The effective antitumor activity of RITA plus 3-MA was also confirmed in vivo in mouse xenograft models transplanted with resistant HNC cells, showing increased oxidative stress and DNA damage. The results indicate that RITA plus 3-MA can help overcome RITA resistance in HNC cells. This study revealed a novel RITA resistant mechanism associated with the sustained induction of autophagy, p62 overexpression, and Keap1-Nrf2 antioxidant system activation. The combined treatment of RITA with the autophagy inhibitor 3-methyladenine overcomes RITA resistance via dual

  16. [Detection and differentiation of Entamoeba histolytica and Entamoeba dispar by polymerase chain reaction in a community in Zulia State, Venezuela].

    Science.gov (United States)

    Rivero, Zulbey; Bracho, Angela; Calchi, Marinella; Díaz, Iris; Acurero, Ellen; Maldonado, Adriana; Chourio, Glenis; Arráiz, Nailet; Corzo, Gilbert

    2009-01-01

    Differential identification of Entamoeba histolytica and Entamoeba dispar is essential for both appropriate patient treatment and epidemiological purposes. To determine the prevalence of these amoeba infections in Santa Rosa de Agua (Maracaibo, Zulia State, Venezuela), a PCR assay using specific primers for each species was standardized and applied. 204 stool samples were analyzed through direct microscopic examination with SSF (0.85%) and lugol, formol-ether concentration, and PCR. Under direct microscopy, 42 individuals (20.58%) presented the E. histolytica/E. dispar complex. Meanwhile PCR showed 47 positive cases for these amoebas: 22 E. histolytica (10.78%), 16 E. dispar (7.84%), and 9 (4.41%) mixed infections. There was no significant difference in the presence of E. histolytica and/or E. dispar according to either gender or age. There were no cases of these amoebas in children under 2 years of age. Observed frequency of E. histolytica (31/204) shows the endemic nature of amoeba infection in this community.

  17. Ritacestus gen. n. (Cestoda: Proteocephalidea) and redescription of R. ritaii comb. n., a parasite of Rita rita (Siluriformes) in India.

    Science.gov (United States)

    de Chambrier, Alain; Scholz, Tomás; Ash, Anirban; Kar, Pradip Kumar

    2011-11-01

    A new genus, Ritacestus, is proposed to accommodate Ritacestus ritaii (Verma, 1926) comb. n. (syn. Proteocephalus ritaii), a parasite of the catfish Rita rita (Hamilton) in India. The new genus, which is placed in the Gangesiinae, is characterized by (i) a small, subspherical scolex formed by four large lobes separated from one another by longitudinal grooves, with a large, widely oval to pyriform rostellum-like apical organ, larger than suckers and possessing an apical hemispherical depression; (ii) paramuscular and cortical position of some vitelline follicles (most follicles are situated medullary); (iii) ventral and dorsal bands of vitelline follicles usually uninterrupted ventral to terminal genitalia and reaching to the posterior margin of proglottides; (iv) the vagina always anterior to the cirrus-sac; (v) a large size of the body (length up to 51 cm); and (vi) development of the uterus of type 2. In its morphology, especially shape of the scolex and apical organ, and paramuscular and cortical position of some vitelline follicles, Ritacestus resembles Postgangesia Akhmerov, 1969, but differs in the presence of a genital atrium (both genital pores of Postgangesia are separate), the anterior position of the vagina (almost always posterior in the latter genus), position of vitelline follicles in cross sections (dorsal and ventral bands in Ritacestus versus only a lateral band in the latter genus), and dorsal excretory canals indistinguishable in mature and gravid proglottides of R. ritaii (well developed in Postgangesia spp.). The type and only species of the genus, R. ritaii, is redescribed on the basis of new material from the type host from the Ganges River basin in India and its neotype is designated.

  18. De los estados fallidos

    OpenAIRE

    Ruiz Medrano, Salvador Francisco

    2011-01-01

    Al presente, desde distintas perspectivas, los Estados fallidos parecieran ser una clasificación más de los Estados en general. Este artículo constituye un intento por revisar dicho concepto, que en nuestros días, últimamente, a cobrando nueva relevancia. La tarea se emprende desde el concepto que el derecho internacional da a los Estados fallidos. Luego se analizan las características políticas del mismo, a través del Índice de Política Exterior y Fondo para la Paz de los...

  19. Anemia y depleción de las reservas de hierro en adolescentes gestantes de una zona urbana y rural del estado Zulia, Venezuela

    OpenAIRE

    Ortega F, Pablo Antonio; Leal M, Jorymar Yoselyn; Chávez, Carlos Javier; Mejías C, Lidia; Chirinos Q, Noraima; Escalona V, Carolina del Pilar

    2012-01-01

    Objetivo: Analizar la prevalencia de anemia y depleción de las reservas corporales de hierro (DRFe) en adolescentes gestantes urbanas (U) y rurales (R). Metodología: Fueron estudiadas 214 adolescentes gestantes (U=100 y R=114), de baja condición socio-económica. Se realizó una evaluación clínica-obstétrica, nutricional y bioquímica. Según recomendaciones de la OMS y el Grupo Consultivo Internacional de Anemia se consideró anemia en gestantes, I y III trimestre Hb≤110g/L, y II trimestre Hb≤105...

  20. Gestión comunicacional de la agenda de internacionalización de los doctorados de la Universidad del Zulia

    Directory of Open Access Journals (Sweden)

    Mary Ollarves

    2012-05-01

    Full Text Available En la presente investigación el objetivo general fue determinar la gestión comunicacional de la agenda de internacionalización de los doctorados de la Universidad del Zulia, en las divisiones de estudios para graduados de las Facultades Ciencias Jurídicas y Políticas, Ciencias Económicas y Sociales y Humanidades y Educación. Se destacan los aportes de los autores Ramírez (2005, Serna (2000, Monzón (2001, Wimmer y Dominick (2001, Rivera (2008, Otegui (2008, Núñez (2008, Trejo (2001; Gacel-ávila (2000, García (2001, Jaramillo y De Lisio (2004, entre otros. El estudio es de tipo cuantitativoy se utilizó como técnica la entrevista semi estructurada dirigida a los directores de: Relaciones Interinstitucionales, General de Comunicación, Divisiones de Estudios para Graduados y Coordinadores de los programas de doctorados, todos de la Universidad del Zulia. La investigación propone integrar la gestión comunicacionala la agenda académica,para promocionar la política de internacionalización de los doctorados de la Universidad del Zulia en el marco de los convenios interinstitucionales. Los resultados demostraron que ciertamente, existe una debilidad en los principios básicos organizacionales y poco interés por proyectar una imagen corporativa, aunque se han hecho adelantos significativos desde la dirección de Relaciones Interinstitucionales y la División de Estudios para Graduados de la Facultad de Humanidades y Educación para posicionarse mundialmente en el área.

  1. Diagnostic of the soils fertility and estimation about the necessities of fertilizers for the watering district of the Zulia River (North of Santander)

    International Nuclear Information System (INIS)

    Sanchez Ortega, Gloria Patricia; Yepes Orjuela, Rodrigo Hernando; Mesa Lopez, Luis Jorge

    1998-01-01

    A diagnosis of the main chemical characteristics of the rice-growing soils of the Zulia River irrigation district (Norte de Santander) was made between the semesters 1994b and 1995a, aimed at identifying the main nutritional limitants and seeking the definition of some parameters on the adequate managements of fertilizers and amends. The use of the pre-existing soil mapping, as well us mineralogical, leaf and irrigation-water quality analysis, associated with a survey carried out among the farmers, allowed for a greater sample precision, better interpretation of the results, and more accurate final recommendations

  2. A Cáritas brasileira e a Economia Popular Solidária: O Agente de Cáritas e a Caridade Libertadora (Brazilian Caritas and the Popular Solidarity Economy: The Agent of Caritas and the Charity Liberating - DOI: 10.5752/P.2175-5841.2013v11n32p1506

    Directory of Open Access Journals (Sweden)

    Joannes Paulus Silva Forte

    2013-12-01

    Full Text Available O presente artigo analisa as ligações entre a Cáritas Brasileira e a Economia Popular Solidária a partir do trabalho do Agente de Cáritas. A problemática central do artigo remete às representações sociais que esses Agentes constroem em seus relatos sobre os princípios da Teologia da Libertação que norteiam os projetos em economia solidária da referida instituição religiosa. A metodologia de base qualitativa e etnográfica consistiu na realização da revisão bibliográfica, consulta a materiais institucionais, observação in loco e entrevistas semiestruturadas com Agentes que atuam na Economia Popular Solidária no estado do Ceará. A análise das representações sinaliza que a própria noção de “Reino de Deus” na terra pressupõe a vinculação profunda entre religião e economia, mística e movimentos sociais, religião e Estado, configurando, dessa forma, um projeto de sociedade contra hegemônico que se vislumbra mediante a transformação radical da base econômica e moral do tecido social contrapondo individualismo à solidariedade. Palavras-chave: Cáritas Brasileira. Economia Popular Solidária. Caridade Libertadora. Teologia da Libertação.  Abstract This article examines the links between Brazilian Caritas and Popular Solidarity Economy from the work of Caritas Agent. The central issue of the article refers to the social representations that these agents build in his histories about the principles of Liberation Theology that guide the projects in solidarity economy of that religious institution. The basic methodology used was qualitative and ethnographic; It consisted in literature review, consultation to institutional materials, observation in loco and semi-structured interviews with agents who act in the Popular Solidarity Economy in the state of Ceará. The analysis of representations indicates that the very notion of "Kingdom of God" on earth presupposes deep linking between religion and economics, mystic

  3. 44 CFR 206.209 - Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major...

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major disaster declarations DR-1603, DR... determinations related to Hurricanes Katrina and Rita (Major disaster declarations DR-1603, DR-1604, DR-1605, DR...

  4. Recognizing history in range ecology: 100 years of science and management on the Santa Rita Experimental Range

    Science.gov (United States)

    Nathan F. Sayre

    2003-01-01

    At the centennial of the Santa Rita Experimental Range, historical analysis is called for on two levels. First, as a major site in the history of range ecology, the Santa Rita illuminates past successes and failures in science and management and the ways in which larger social, economic, and political factors have shaped scientific research. Second, with the turn away...

  5. Monitoring Inland Storm Surge and Flooding from Hurricane Rita

    Science.gov (United States)

    McGee, Benton D.; Tollett, Roland W.; Mason, Jr., Robert R.

    2006-01-01

    Pressure transducers (sensors) and high-water marks were used to document the inland water levels related to storm surge generated by Hurricane Rita in southwestern Louisiana and southeastern Texas. On September 22-23, 2005, an experimental monitoring network of sensors was deployed at 33 sites over an area of about 4,000 square miles to record the timing, extent, and magnitude of inland hurricane storm surge and coastal flooding. Sensors were programmed to record date and time, temperature, and barometric or water pressure. Water pressure was corrected for changes in barometric pressure and salinity. Elevation surveys using global-positioning systems and differential levels were used to relate all storm-surge water-level data, reference marks, benchmarks, sensor measuring points, and high-water marks to the North American Vertical Datum of 1988 (NAVD 88). The resulting data indicated that storm-surge water levels over 14 feet above NAVD 88 occurred at three locations, and rates of water-level rise greater than 5 feet per hour occurred at three locations near the Louisiana coast.

  6. Entrevista a María Rita Otero

    Directory of Open Access Journals (Sweden)

    Olga Lucia Castiblanco Abril

    2016-09-01

    Full Text Available OC: Dra. María Rita, bienvenida a esta sección de la revista en donde siempre queremos que nuestros lectores conozcan personas de la vida académica en el campo de la investigación en Enseñeanza de las Ciencias. En primer lugar, nos gustaría que nos contara algo sobre su lugar actual como docente e invstigadora. MRO: Muchas gracias por la invitación. Quisiera contarles que hasta hace dos años fui profesora de secundaria durante 33 años. Actualmente soy profesora titular de la Universidad del Centro de la Provincia de Buenos Aires y soy investigadora principal del Consejo Nacional de Ciencia y tecnología de la República Argentina (Conicet. OC: ¿Cuál es su área de investigación? MRO: Estoy adscrita en el área de psicología y educación. Dentro de esta área trabajo en didáctica de las ciencias. Dirijo un equipo dentro de la universidad que se dedica a esto y a formar profesores de matemáticas, física e informática y también dirijo el doctorado.

  7. Status of the RITA - experiment on EURECA. [Radio Frequency Ion Thrustor Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Bassner, H.; Berg, H.P.; Birner, W.; Bartoli, C.; Trippi, A.

    1987-01-01

    The radiofrequency ion thruster assembly (RITA) is currently built as a flight experiment which shall be flown on the European retrievable carrier (Eureca I). This test flight shall verify the operational use of this electric propulsion system in space by demonstration of operation, lifetime and reliability. For this purpose the RITA experiment has been adapted to meet the specific constraints imposed by the Eureca I spacecraft and by the Space Shuttle as the launcher; xenon gas will be used as the propellant and the experiment will be operated automatically by means of a dedicated on-board microcomputer system. According to the delay in launches by the Space Shuttle the launch date has been postponed from March 1988 to 1991/92. Therefore the total Eureca program has been extended, which also influenced the RITA time schedule.

  8. The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer.

    Science.gov (United States)

    Roh, Jong-Lyel; Ko, Jung Ho; Moon, Soo Jin; Ryu, Chang Hwan; Choi, Jun Young; Koch, Wayne M

    2012-12-01

    We evaluated whether the restoration of p53 function by the p53-reactivating small molecule RITA (reactivation of p53 and induction of tumor cell apoptosis enhances cisplatin-induced cytotoxicity and apoptosis in head-and-neck cancer (HNC). RITA induced prominent accumulation and reactivation of p53 in a wild-type TP53-bearing HNC cell line. RITA showed maximal growth suppression in tumor cells showing MDM2-dependent p53 degradation. RITA promoted apoptosis in association with upregulation of p21, BAX, and cleaved caspase-3; notably, the apoptotic response was blocked by pifithrin-α, demonstrating its p53 dependence. With increasing concentrations, RITA strongly induced apoptosis rather than G2-phase arrest. In combination therapy, RITA enhanced cisplatin-induced growth inhibition and apoptosis of HNC cells invitro and in vivo. Our data suggest that the restoration of p53 tumor-suppressive function by RITA enhances the cytotoxicity and apoptosis of cisplatin, an action that may offer an attractive strategy for treating HNC. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  9. The Recent Infection Testing Algorithm (RITA) in clinical practice: a survey of HIV clinicians in England and Northern Ireland.

    Science.gov (United States)

    Garrett, Nj; Lattimore, S; Gilbart, Vl; Aghaizu, A; Mensah, G; Tosswill, J; Murphy, G; Delpech, V

    2012-08-01

    In order to estimate HIV incidence among high-risk groups, in January 2009 the Health Protection Agency introduced the Recent Infection Testing Algorithm (RITA) in England and Northern Ireland (E&NI), currently the only regions to inform patients of RITA results. This survey of HIV specialists aimed to investigate the role of RITA in patient management and explore clinicians' views on its role in clinical practice and during partner notification. An online questionnaire was distributed to HIV specialists via the British HIV Association membership email list in February 2011. Forty-two HIV specialists from 32 HIV centres responded to the survey among 90 centres enrolled in the programme (response rate 36%). Testing for recent infection was considered standard of care by 83% of respondents, 80% felt confident in interpreting results and 92% discussed results with patients, particularly in the context of a possible HIV seroconversion illness (96%) or when deciding when to start antiretroviral therapy (70%). A third (36%) of specialists were initially concerned that RITA results may cause additional anxiety among patients; however, no adverse events were reported. The majority (90%) felt that results could assist with contact tracing by prioritizing patients with likely recent infection. However, only a few centres have currently incorporated RITA into their HIV partner notification protocols. RITA has been introduced into clinical practice with no reported patient adverse events. Access to results at centre level should be improved. National guidance regarding use of RITA as a tool for contact tracing is required. © 2012 British HIV Association.

  10. RITA enhances chemosensivity of pre-B ALL cells to doxorubicin by inducing p53-dependent apoptosis.

    Science.gov (United States)

    Kazemi, Ahmad; Safa, Majid; Shahbazi, Atefeh

    2011-07-01

    The use of low-molecular-weight, non-peptidic molecules that disrupt the interaction between the p53 tumor suppressor and its negative regulator MDM2 has provided a promising alternative for the treatment of different types of cancer. Here, we used small-molecule reactivation of p53 and induction of tumor cell apoptosis (RITA) to sensitize leukemic NALM-6 cells to doxorubicin by upregulating p53 protein. RITA alone effectively inhibited NALM-6 cells viability in dose-dependent manner as measured by 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide assay and induced apoptosis as evaluated by flow cytometry, whereas RITA in combination with doxorubicin enhanced NALM-6 cells to doxorubicin-sensitivity and promoted doxorubicin induced apoptosis. Levels of p53 protein and its proapoptotic target genes, quantified by western blot and real-time PCR respectively, showed that expression of p53 was significantly increased after RITA treatment. Using p53 inhibitors PFT-alpha and PFT-mu it was shown that p53-mediated apoptosis induced by RITA can be regulated by both p53-transcription-dependent and -independent pathways. Moreover, RITA-induced apoptosis was accompanied by the activation of caspase-3 and PARP cleavage. Therefore, exploiting synergistic effects between RITA and chemotherapeutics might be an effective clinical strategy for leukemia chemotherapy.

  11. La Universidad del Zulia frente al proceso de transformación organizacional. Perspectiva de algunos actores del proceso

    Directory of Open Access Journals (Sweden)

    Juliana Ferrer

    2002-01-01

    Full Text Available La gerencia universitaria de hoy, requiere asumir un proceso de transformación organizacional, que le permita describir un equilibrio entre su identidad institucional y los cambios sustanciales exigidos desde todos sus ámbitos, a fin de mejorar los procesos académicos, cohesionar con éxito las funciones básicas y por ende lograr la calidad académica deseada. Surge como inquietud el presente artículo el cual pretende indagar sobre algunos esfuerzos que la Universidad del Zulia ha adelantado en este sentido, pero sobre todo hacer énfasis en la perspectiva de algunos actores del proceso, representados por el personal docente y de investigación, que para el período 2000-2001 se desempeño como personal directivo Para la recolección de los datos se asumió en primer término la técnica cualitativa del grupo focal, permitiendo así lograr suficiente información para aplicar luego, una muestra probabilística que arrojó un tamaño de 39 unidades con un nivel de confianza del 95%. Se concluye que los gerentes universitarios están conscientes de los problemas de carácter operativo que obstaculizan el proceso de cohesión exitosa de las funciones básicas. Sin embargo, no evidencian conocimiento exhaustivo sobre el desarrollo de procesos gerenciales, para el logro de los cursos de acción enunciados por esos mismos actores. Se recomienda sobre la necesidad de formar una gerencia universitaria sólida, en el compromiso de la labor constante en materia de información y conocimiento, de tal forma que los cambios implantados sean percibidos de manera objetiva, internalizados y compartidos por la comunidad universitaria, en la búsqueda de que ellos se conviertan en piezas del proceso de cambio institucional.

  12. Procesos de aprendizaje en el sistema de educación a distancia de la Universidad del Zulia

    Directory of Open Access Journals (Sweden)

    Nelvin Andrade

    2015-01-01

    Full Text Available La presente investigación acción en el aula, orientada por su propósito de fortalecer la educación a distancia en los programas EUS del núcleo LUZ Costa Oriental del Lago. El estudio se articuló en la complementariedad de enfoques como la etnografía, hermenéutica dialógica, guiados por la transdisciplinariedad del accionar con y desde los actores. Destacan como estrategias de acción reflexiva, talleres de formación, blog educativos, círculos de reflexión para la desconstrucción, reorientación, e implementación programática y paradigmática de las aulas virtuales. Logrando contrastar, desde el paradigma crítico reflexivo, cómo se facilitan los aprendizajes en correspondencia con los desafíos del tercer milenio, situación que estaba caracterizada por escasa formación y compromiso de algunos docentes de dicha coordinación sobre la educación a distancia, plataforma tecnológica deficiente, obsolescencia de contenidos programáticos, elevados índices de aplazados, entre otros. El análisis fue sistematizado desde la triangulación hermenéutica. Entre sus transformaciones destacan: mejora en las competencias tecnológicas, académicas de los actores, implementación de cinco aulas virtuales, actualización de la plataforma tecnológica, actualización programática y paradigmática de las unidades adscritas a la mencionada coordinación, reorientación a los criterios de evaluación desde una concepción formativa, brindándoles mayores oportunidades al estudiante para su autorregulación, tomando en cuenta su ritmo de aprendizaje, fortalecimiento de la redes de docentes investigadores, que facilitan aprendizajes en todas las dependencias EUS, de La Universidad del Zulia.

  13. Rangeland livestock production: Developing the concept of sustainability on the Santa Rita Experimental Range

    Science.gov (United States)

    George B. Ruyle

    2003-01-01

    The Santa Rita Experimental Range (SRER) was established in 1903 at the behest of concerned stockmen and researchers as the first facility in the United States set aside to study range livestock production. At the time, severe overgrazing of the public domain had seriously reduced carrying capacities of Southwestern rangelands. Researchers on the SRER developed and...

  14. Archive and laboratory embedded in the landscape: Future of the Santa Rita Experimental Range

    Science.gov (United States)

    Thomas E. Sheridan

    2003-01-01

    The Santa Rita Experimental Range (SRER) is both an archive of past ecological research and a laboratory for continuing research embedded in the southern Arizona landscape. The scientific questions being asked there have changed over the last 100 years, but SRER with its monitoring stations and its legacy of repeat photography still offers a unique opportunity to study...

  15. Sweet resin bush on the Santa Rita Experimental Range: An eradication effort

    Science.gov (United States)

    Larry D. Howery; Bruce D. Munda; Dan G. Robinett; Harry H. Buck

    2003-01-01

    Sweet resin bush (Euryops subcarnosus DC ssp. vulgaris B. Nord; or, Euryops multifidis (L. f.) DC.), a South African shrub introduced to Arizona in the 1930s, was discovered on the Santa Rita Experimental Range (SRER) in 1998. Due to the threat of spread of this invasive plant and its potential to cause adverse environmental and economic effects, and because it posed a...

  16. 75 FR 22770 - Gary E. Hall and Rita Hall; Notice of Availability of Environmental Assessment

    Science.gov (United States)

    2010-04-30

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 13652-000-Montana] Gary E. Hall and Rita Hall; Notice of Availability of Environmental Assessment April 22, 2010. In accordance with the National Environmental Policy Act of 1969, as amended, and the Federal Energy Regulatory...

  17. "Making Lemonade from Lemons:" Early Childhood Teacher Educators' Programmatic Responses to Hurricanes Katrina and Rita

    Science.gov (United States)

    DiCarlo, Cynthia F.; Burts, Diane C.; Buchanan, Teresa K.; Aghayan, Carol; Benedict, Joan

    2007-01-01

    This article describes how early childhood teacher education faculty at one university responded in the aftermath of hurricanes Katrina and Rita and used the disaster to enhance their undergraduate and graduate programs. They explain how they modeled developmentally appropriate practices while responding to community needs. Four companion articles…

  18. Vascular plants and a brief history of the Kiowa and Rita Blanca National Grasslands

    Science.gov (United States)

    Donald L. Hazlett; Michael H. Schiebout; Paulette L. Ford

    2009-01-01

    Administered by the USDA Forest Service, the Kiowa and Rita Blanca National Grasslands occupy 230,000 acres of public land extending from northeastern New Mexico into the panhandles of Oklahoma and Texas. A mosaic of topographic features including canyons, plateaus, rolling grasslands and outcrops supports a diverse flora. Eight hundred twenty six (826) species of...

  19. Inelastic neutron scattering experiments with the monochromatic imaging mode of the RITA-II spectrometer

    DEFF Research Database (Denmark)

    Bahl, Christian Robert Haffenden; Lefmann, Kim; Abrahamsen, Asger Bech

    2006-01-01

    Recently a monochromatic multiple data taking mode has been demonstrated for diffraction experiments using a RITA type cold neutron spectrometer with a multi-bladed analyser and a position-sensitive detector. Here, we show how this mode can be used in combination with a flexible radial collimator...

  20. Missed by the Mass Media: The Houma, Pointe-au-Chien, and Hurricanes Katrina and Rita

    Science.gov (United States)

    Collins, Robert Keith

    2008-01-01

    This case study investigates the media discourse from Houma and Pointe-au-Chien tribal leaders in Louisiana on their experiences with Hurricanes Katrina and Rita. One section briefly engages the discourse as discernable from the reports found in Native American and non-Native American news media. Included is a brief yet close examination of these…

  1. Lightcurves for Shape Modeling: 852 Wladilena, 1089 Tama, and 1180 Rita

    Science.gov (United States)

    Polishook, David

    2012-10-01

    The folded lightcurves and synodic periods of 852 Wladilena, 1089 Tama, and 1180 Rita are reported. The data are used by Hanus et al. (2012) to derive the rotation axis and to construct a shape model by applying the inversion lightcurve technique.

  2. REMOTE SENSING DAMAGE ASSESSMENT OF CHEMICAL PLANTS AND REFINERIES FOLLOWING HURRICANES KATRINA AND RITA

    Science.gov (United States)

    The massive destruction brought by Hurricanes Katrina and Rita also impacted the many chemical plants and refineries in the region. The achievement of this rapid analysis capability highlights the advancement of this technology for air quality assessment and monitoring. Case st...

  3. Rita Lobato: a primeira médica formada no Brasil

    Directory of Open Access Journals (Sweden)

    Francisco Bruno Lobo

    2017-04-01

    Dentre elas foi escolhida a primeira mulher que se diplomou em medicina em uma Faculdade brasileira: A Dra. Rita Lobato de Freitas . No dia 9 de junho, aniversário de seu nascimento, o referido sêlo entrou em circulação.

  4. Geology of Santa Rita Coal Basin, Rio Grande do Sul, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Correa da Silva, Z.C.; Bortoluzzi, C.A.; Cazzulo-Klepzig, M.; Dias-Fabricio, M.E.; Guerra-Sommer, M.; Marques-Toigo, M.; Paim, P.S.G.; Piccoli, A.E.M.; Silva Filho, B.C.

    1984-04-01

    Data on the sedimentology, stratigraphy, palynology, coal petrography and geochemistry of the Santa Rita Coal Basin, Rio Grande do Sul, Brazil, are presented. The investigations were carried out on samples obtained from drill cores of the sedimentary rocks of Tubarao Supergroup, Lower Permian of Parana Basin. (25 refs.)

  5. The Impact of Hurricanes Katrina and Rita on Louisiana School Nurses

    Science.gov (United States)

    Broussard, Lisa; Myers, Rachel; Meaux, Julie

    2008-01-01

    In the fall of 2005, the coast of Louisiana was devastated by two hurricanes, Katrina and Rita. Not only did these natural disasters have detrimental effects for those directly in their path, the storms had an impact on the lives of everyone in Louisiana. The professional practice of many Louisiana school nurses was affected by several factors,…

  6. Metal concentrations in schoolyard soils from New Orleans, Louisiana before and after Hurricanes Katrina and Rita.

    Science.gov (United States)

    Presley, Steven M; Abel, Michael T; Austin, Galen P; Rainwater, Thomas R; Brown, Ray W; McDaniel, Les N; Marsland, Eric J; Fornerette, Ashley M; Dillard, Melvin L; Rigdon, Richard W; Kendall, Ronald J; Cobb, George P

    2010-06-01

    The long-term environmental impact and potential human health hazards resulting from Hurricanes Katrina and Rita throughout much of the United States Gulf Coast, particularly in the New Orleans, Louisiana, USA area are still being assessed and realized after more than four years. Numerous government agencies and private entities have collected environmental samples from throughout New Orleans and found concentrations of contaminants exceeding human health screening values as established by the United States Environmental Protection Agency (USEPA) for air, soil, and water. To further assess risks of exposure to toxic concentrations of soil contaminants for citizens, particularly children, returning to live in New Orleans following the storms, soils collected from schoolyards prior to Hurricane Katrina and after Hurricane Rita were screened for 26 metals. Concentrations exceeding USEPA Regional Screening Levels (USEPA-RSL), total exposure, non-cancer endpoints, for residential soils for arsenic (As), iron (Fe), lead (Pb), and thallium (Tl) were detected in soil samples collected from schoolyards both prior to Hurricane Katrina and after Hurricane Rita. Approximately 43% (9/21) of schoolyard soils collected prior to Hurricane Katrina contained Pb concentrations greater than 400mgkg(-1), and samples from four schoolyards collected after Hurricane Rita contained detectable Pb concentrations, with two exceeding 1700mgkg(-1). Thallium concentrations exceeded USEPA-RSL in samples collected from five schoolyards after Hurricane Rita. Based upon these findings and the known increased susceptibility of children to the effects of Pb exposure, a more extensive assessment of the soils in schoolyards, public parks and other residential areas of New Orleans for metal contaminants is warranted. 2010 Elsevier Ltd. All rights reserved.

  7. Hurricane Rita Track Radar Image with Topographic Overlay

    Science.gov (United States)

    2005-01-01

    [figure removed for brevity, see original site] Animation About the animation: This simulated view of the potential effects of storm surge flooding on Galveston and portions of south Houston was generated with data from the Shuttle Radar Topography Mission. Although it is protected by a 17-foot sea wall against storm surges, flooding due to storm surges caused by major hurricanes remains a concern. The animation shows regions that, if unprotected, would be inundated with water. The animation depicts flooding in one-meter increments. About the image: The Gulf Coast from the Mississippi Delta through the Texas coast is shown in this satellite image from NASA's Moderate Resolution Imaging Spectroradiometer (MODIS) overlain with data from the Shuttle Radar Topography Mission (SRTM), and the predicted storm track for Hurricane Rita. The prediction from the National Weather Service was published Sept. 22 at 4 p.m. Central Time, and shows the expected track center in black with the lighter shaded area indicating the range of potential tracks the storm could take. Low-lying terrain along the coast has been highlighted using the SRTM elevation data, with areas within 15 feet of sea level shown in red, and within 30 feet in yellow. These areas are more at risk for flooding and the destructive effects of storm surge and high waves. Data used in this image were acquired by the Shuttle Radar Topography Mission aboard the Space Shuttle Endeavour, launched on Feb. 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect 3-D measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter (approximately 200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Geospatial

  8. Golpes de Estado

    Directory of Open Access Journals (Sweden)

    Roberto Cortazar

    1966-04-01

    Full Text Available Por golpes de Estado se ha entendido generalmente un acto subversivo tendiente al cambio de régimen de gobierno o a la deposición de un magistrado supremo, acto que suelen llevar a cabo, en nombre de un partido, los politicos que anhelan de buena o mala fe verificar la transformación en un momento dado, después de propiciar el terreno por medio de la oposición.

  9. La presencia de la comunicación en los principios básicos organizacionales de la Universidad del Zulia hacia el sector estudiantil

    Directory of Open Access Journals (Sweden)

    Laura Castellano Ramírez

    2006-11-01

    Full Text Available This article is centered in detecting the presence of comunication towards the student sector, like a formal element in the redaccion of the organization basic principles (OBP of La Universidad del Zulia, such as Mision, Vision, Values, Polítics, Objectives and Strategies. Starting from the theoric approach of that the OBP conform the basic component of the Corporative Identity, in wish are rised the other three: the organizational beheivier, the simbology or visual identity and the comunication. Through the documentary research it has concluded that the communication towards the student community is not taken in count in the redaction of the basic principles, it is mentioned only in the comunicational politic but in a very general way.

  10. del Estado Aragua

    Directory of Open Access Journals (Sweden)

    Joselys Cintia Zerpa

    2008-01-01

    Full Text Available Diagnostica la situación actual de los bienes que conforman al patrimonio histórico-cultural del Municipio Zamora, Estado Aragua, Venezuela. La Investigación es descriptiva y de campo, comprendió la elaboración de un inventario de los bienes inmuebles, festividades religiosas y manifestaciones artesanales del municipio. Se estudiaron la condición física y uso actual de estos bienes y los planes y proyectos existentes. Analizó el marco normativo que los rige. Se obtuvo la opinión de los representantes de organismos públicos relacionados con la actividad turística del Municipio, de los visitantes, cronistas e historiadores. Aportes: La mayoría de los bienes se encuentran en buen estado de conservación, Las manifestaciones culturales, festividades y la artesanía se desarrollan periódicamente pero no son aprovechadas turísticamente, Se determinó que existe un marco normativo para tales bienes y No existen propuestas actuales referentes a estos bienes. Se reflejó el interés de los sectores institucional y privado para la incorporación de estos bienes a la oferta turística del Municipio y del Estado

  11. Hurricane Rita Aerial Photography: High-Resolution Imagery of the Texas and Louisiana Gulf Coast After Landfall

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The imagery posted on this site is of the Texas and Louisiana Gulf Coast after Hurricane Rita made landfall. The regions photographed range from San Luis Pass, Texas...

  12. METODOLOGÍA PARA PRÁCTICAS EN LABORATORIOS DE DISEÑO MECÁNICO. UNA EXPERIENCIA DOCENTE EN LA UNIVERSIDAD DEL ZULIA

    Directory of Open Access Journals (Sweden)

    Yajaira Alvarado

    2011-01-01

    Full Text Available El presente artículo tiene como objetivo determinar los parámetros fundamentales que generen una metodología pertinente para la inserción de las prácticas en el laboratorio técnico de diseño mecánico de la Universidad del Zulia Núcleo Costa Oriental del Lago. El estudio es descriptivo transeccional con un diseño de campo no experimental. El instrumento de recolección de datos fue el cuestionario. La población estuvo conformada por 10 profesores que administran académicamente las unidades curriculares adscritas en el área de diseño mecánico. Por ser una población finita se empleó el censo poblacional. Los resultados determinaron la necesidad de diseñar una serie de prácticas relacionadas con: Mecánica de Sólidos, Elementos de Máquinas, Dinámica, Estática y Mecánica de Máquinas, con lo cual exista una conexión entre lo establecido en el plan curricular de La Universidad del Zulia (LUZ y el proyecto del laboratorio técnico del Núcleo; de tal forma que el estudiante sea preparado como un individuo integral, capaz de desenvolverse dentro de una sociedad del conocimiento enmarcada en el fenómeno de la globalización, en pro de una formación integral ajustada al desarrollo de competencias especificas como lo establece la nueva resolución del Ministerio de Educación Superior de Venezuela, a fin de que el egresado se relacione, directamente, con el sector productivo.

  13. Diagnóstico de la fertilidad de los suelos y estimativos sobre las necesidades de fertilizantes para el distrito de riego del Río Zulia (Norte de Santander Fertility diagnosis and fertilizer estimates for the soils of the Zulia River Irrigation District (Norte de Santander

    Directory of Open Access Journals (Sweden)

    Sánchez Ortega Gloria Patricia

    1996-12-01

    Full Text Available Entre los semestres 1994 B y 1995 A, se realizó un diagnóstico de las principales características químicas de los suelos arroceros del Distrito de Riego del Río Zulia (Norte de Santander, con el fin de identificar las principales limitantes nutricionales y definir parámetros sobre el manejo adecuado de fertilizantes y correctivos. EI uso de levantamiento de suelos preexistente, al igual que los análisis mineralógicos, foliares y de calidad de aguas para riego, en asocio con la encuesta realizada a los agricultores, permitieron una mayor precisión en el muestreo, la interpretación de los resultados y las recomendaciones finales.A diagnosis of the main chemical characteristics of the rice-growing soils of the Zulia river irrigation district (Norte de Santander was made between the semesters 19948 and 1995A, aimed at identifying the main nutritional constraints, and defining some parameters on the adequate managements of fertilizers and amendments. The use of the pre-existing soil mapping, as well as mineralogical, leaf and irrigation-water quality analyses, associated with a poll carried out among the farmers, allowed for a greater sample-precision, better interpretation of the results, and more accurate final recomendations.

  14. Flora pteridofítica de fragmentos florestais do Parque Estadual de Vassununga – Santa Rita do Passa Quatro, SP. Pteridophyte flora of forest fragments in Vassununga State Park – Santa Rita do Passa Quatro, São Paulo, Brazil.

    Directory of Open Access Journals (Sweden)

    Áurea Maria Therezinha COLLI

    2014-06-01

    Full Text Available Este trabalho apresenta o levantamento da flora pteridofítica de dois fragmentos florestais do Parque Estadual de Vassununga, unidade de conservação localizada no município de Santa Rita do Passa Quatro, SP. Para tanto, foram realizadas onze excursões por caminhos e trilhas de fiscalização e de pesquisa. Na Gleba Maravilha, que apresenta vegetação de Floresta Estacional Semidecidual Montana e Floresta Estacional Semidecidual Aluvial com inundação temporária, foram encontradas 10 famílias, 18 gêneros e 35 espécies, sendo Pteridaceae, Thelypteridaceae, Aspleniaceae, e Polypodiaceae as famílias mais ricas com nove, sete, seis e cinco espécies, respectivamente. Na Gleba Capão da Várzea, onde ocorre a Floresta Paludosa e o Campo Antrópico, ocorreram nove famílias, 14 gêneros e 24 espécies, onde Thelypteridaceae e Polypodiaceae se apresentaram como as mais ricas, com oito e seis espécies, respectivamente. As Glebas do Parque Estadual de Vassununga com as suas diferentes fisionomias vegetais são áreas importantes para a conservação de pteridófitas na região nordeste do Estado de São Paulo, principalmente as típicas de Floresta Estacional Semidecidual Montana e de Floresta Paludosa como Blechnum brasiliense, Campyloneurum angustifolium, Cyclodium meniscioides, Osmunda regalis, Pityrogramma calomelanos e Thelypteris opposita. This work presents a survey on pteridophyte flora of two forest fragments in Vassununga State Park, a conservation unit located in the city of Santa Rita do Passa Quatro, São Paulo, Brazil. In order to carry out the survey, a series of eleven tours on old inspection and research trails were made. In the Maravilha Tract, which consists of Seasonal Semi-Deciduous Montane Forest and Seasonal Semideciduous Alluvial Forest with temporary flooding, 10 families, 18 genera, and 35 species were found, the richest families were Pteridaceae, Thelypteridaceae, Aspleniaceae, and Polypodiaceae, with nine, seven

  15. An Axisymmetric View of Concentric Eyewall Evolution in Hurricane Rita (2005)

    Science.gov (United States)

    2012-08-01

    of Hurricane Hugo (1989). Mon. Wea. Rev., 136, 1237–1259. Martinez, Y., G. Brunet, and M. K. Yau, 2010: On the dynamics of two-dimensional hurricane ...An Axisymmetric View of Concentric Eyewall Evolution in Hurricane Rita (2005) MICHAEL M. BELL Naval Postgraduate School, Monterey, California, and... Hurricane Research Division, Miami, Florida WEN-CHAU LEE National Center for Atmospheric Research,* Boulder, Colorado (Manuscript received 23 June 2011, in

  16. Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma.

    Science.gov (United States)

    Di Marzo, Domenico; Forte, Iris Maria; Indovina, Paola; Di Gennaro, Elena; Rizzo, Valeria; Giorgi, Francesca; Mattioli, Eliseo; Iannuzzi, Carmelina Antonella; Budillon, Alfredo; Giordano, Antonio; Pentimalli, Francesca

    2014-01-01

    Malignant mesothelioma, a very aggressive tumor associated to asbestos exposure, is expected to increase in incidence, and unfortunately, no curative modality exists. Reactivation of p53 is a new attractive antitumoral strategy. p53 is rarely mutated in mesothelioma, but it is inactivated in most tumors by the lack of p14(ARF). Here, we evaluated the feasibility of this approach in pleural mesothelioma by testing RITA and nutlin-3, two molecules able to restore p53 function through a different mechanism, on a panel of mesothelioma cell lines representing the epithelioid (NCI-H28, NCI-H2452, IST-MES 2), biphasic (MSTO-211H), and sarcomatoid (NCI-H2052) histotypes compared with the normal mesothelial HMC-hTERT. RITA triggered robust caspase-dependent apoptosis specifically in epithelioid and biphasic mesothelioma cell lines, both through wild-type and mutant p53, concomitant to p21 downregulation. Conversely, nutlin-3 induced a p21-dependent growth arrest, rather than apoptosis, and was slightly toxic on HMC-hTERT.   Interestingly, we identified a previously undetected point mutation of p53 (p.Arg249Ser) in IST-MES 2, and showed that RITA is also able to reactivate this p53 mutant protein and its apoptotic function. RITA reduced tumor growth in a MSTO-211H-derived xenograft model of mesothelioma and synergized with cisplatin, which is the mainstay of treatment for this tumor. Our data indicate that reactivation of p53 and concomitant p21 downregulation effectively induce cell death in mesothelioma, a tumor characterized by a high intrinsic resistance to apoptosis. Altogether, our findings provide the preclinical framework supporting the use of p53-reactivating agents alone, or in combination regimens, to improve the outcome of patients with mesothelioma.

  17. Effects of marsh pond terracing on coastal wintering waterbirds before and after Hurricane Rita.

    Science.gov (United States)

    O'Connell, Jessica L; Nyman, John A

    2011-11-01

    From February to March 2005-2006, we surveyed wintering waterbirds to test effects of terracing on coastal pond use before and after Hurricane Rita. Marsh terracing is intended to slow coastal marsh loss in the Chenier Plain by slowing marsh erosion and encouraging vegetation expansion. Terraces also increase marsh edge in ponds, possibly benefiting waterbirds. We monitored paired terraced and unterraced ponds in three sites within southwestern Louisiana's Chenier Plain. Waterbirds were 75% more numerous in terraced than unterraced ponds. Waterbird richness was similar among ponds when corrected for number of individuals, suggesting terracing increased bird density but did not provide habitat unique from unterraced ponds. Birds were 93% more numerous following Hurricane Rita, mostly due to an influx of migrating waterfowl. Year round residents were similar in number before and after Hurricane Rita. Resident richness did not differ among years after correcting for number of observed individuals. Wading and dabbling foragers were more abundant in terraced ponds and these two guilds represented 74% of birds observed. We detected no difference among ponds for other guilds, i.e., probing, aerial, and diving foragers. Increasing proportion of mash edge increased bird density disproportionately: On average ponds with 10% edge had 6 birds observed and ponds with 30% edge had 16 birds observed. Terraces increased habitat interspersion and were an effective tool for increasing numbers of wintering waterfowl and wading birds. The extent to which terraces were sustainable following hurricane forces is unknown.

  18. Effects of Marsh Pond Terracing on Coastal Wintering Waterbirds Before and After Hurricane Rita

    Science.gov (United States)

    O'Connell, Jessica L.; Nyman, John A.

    2011-11-01

    From February to March 2005-2006, we surveyed wintering waterbirds to test effects of terracing on coastal pond use before and after Hurricane Rita. Marsh terracing is intended to slow coastal marsh loss in the Chenier Plain by slowing marsh erosion and encouraging vegetation expansion. Terraces also increase marsh edge in ponds, possibly benefiting waterbirds. We monitored paired terraced and unterraced ponds in three sites within southwestern Louisiana's Chenier Plain. Waterbirds were 75% more numerous in terraced than unterraced ponds. Waterbird richness was similar among ponds when corrected for number of individuals, suggesting terracing increased bird density but did not provide habitat unique from unterraced ponds. Birds were 93% more numerous following Hurricane Rita, mostly due to an influx of migrating waterfowl. Year round residents were similar in number before and after Hurricane Rita. Resident richness did not differ among years after correcting for number of observed individuals. Wading and dabbling foragers were more abundant in terraced ponds and these two guilds represented 74% of birds observed. We detected no difference among ponds for other guilds, i.e., probing, aerial, and diving foragers. Increasing proportion of mash edge increased bird density disproportionately: On average ponds with 10% edge had 6 birds observed and ponds with 30% edge had 16 birds observed. Terraces increased habitat interspersion and were an effective tool for increasing numbers of wintering waterfowl and wading birds. The extent to which terraces were sustainable following hurricane forces is unknown.

  19. SISTEM INFORMASI DAN PENGOLAHAN DATA GAJI KARYAWAN PADA RITA PASARAYA KEBONDALEM PURWOKERTO

    Directory of Open Access Journals (Sweden)

    Nyoman Heddy Triyodanta

    2009-02-01

    Full Text Available Penelitian ini berjudul "Sistem Informasi dan Pengolahan Data GajiKaryawan pada Rita Pasaraya Kebondalem Purwokerto". Tujuan dari penelitian iniodalah untuk mengetahui prosedur sistem informasi pengolahan data gaji karynvanyang sedang berjalan atau sedang dipakai pada Rita Pasaraya KebondalemPurwoketo, yang masih dilakukan dengan proses manual dan pada akhirnyadirancang suatu sistem informasi yang lebih baik. Merancang sistem informasi yangberbasis komputer untuk membantu mengatasi kelemahan dalam pengolahan datamenjadi informasi sesuai dengan kebutuhan user. Hasil analisis menunjukkan bahwapengolahan data di Rita Pasaraya Kebondalem Purwokerto mosih menggunakansistem manual. Sistem yang baru yaitu komputerisasi akan lebih tepat biladipergunakan untuk kehandalan data gaji karyawan. Selain sistem yang baru secarakomputerisasi kedisiplinan pemakai juga perlu ditingkatkan, secara fasilitastambahan selain ruangan khusus yaitu adanya Air Condisioner (AC pada ruangkomputer untuk membuat awet secara perangkat keras komputer dan komputer dapatdihidupkan secara terus menerus. Sistem yang baru aknn menambah kepercayaanImryawan dan pihak lain yang membutuhkan karena akurat, tepat dan handal. Sertapengambilan keputusan tentang kondisi data gaji karyawan dapat lebih alatrat dancepat yang tidak lain dapat meningkatkan kinerja karyawan terhadap perusahaan.

  20. Sediment deposition from Hurricane Rita on Hackberry Beach chenier in southwestern Louisiana: Chapter 6E in Science and the storms-the USGS response to the hurricanes of 2005

    Science.gov (United States)

    Faulkner, Stephen; Barrow, Wylie; Doyle, Thomas; Baldwin, Michael; Michot, Thomas; Wells, Christopher; Jeske, Clint

    2007-01-01

    Hurricane Rita significantly impacted the chenier forests of southwestern Louisiana, an important habitat for Neotropical migratory birds. Sediment deposition was measured along transects at Hackberry Beach chenier, and Rita's effects on chenier structure and morphology were determined.

  1. Recolecta: estado actual y perspectivas

    OpenAIRE

    López Medina, Alicia

    2010-01-01

    Estado actual del Recolector de ciencia abierta español: Recolecta y proyectos de futuro. López Medina, A. (2010). Recolecta: estado actual y perspectivas. X Workshop Rebiun sobre proyectos digitales. http://hdl.handle.net/10251/8710.

  2. Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents.

    Science.gov (United States)

    Michaelis, M; Rothweiler, F; Agha, B; Barth, S; Voges, Y; Löschmann, N; von Deimling, A; Breitling, R; Doerr, H Wilhelm; Rödel, F; Speidel, D; Cinatl, J

    2012-04-05

    Adaptation of wild-type p53 expressing UKF-NB-3 cancer cells to the murine double minute 2 inhibitor nutlin-3 causes de novo p53 mutations at high frequency (13/20) and multi-drug resistance. Here, we show that the same cells respond very differently when adapted to RITA, a drug that, like nutlin-3, also disrupts the p53/Mdm2 interaction. All of the 11 UKF-NB-3 sub-lines adapted to RITA that we established retained functional wild-type p53 although RITA induced a substantial p53 response. Moreover, all RITA-adapted cell lines remained sensitive to nutlin-3, whereas only five out of 10 nutlin-3-adapted cell lines retained their sensitivity to RITA. In addition, repeated adaptation of the RITA-adapted sub-line UKF-NB-3(r)RITA(10 μM) to nutlin-3 resulted in p53 mutations. The RITA-adapted UKF-NB-3 sub-lines displayed no or less pronounced resistance to vincristine, cisplatin, and irradiation than nutlin-3-adapted UKF-NB-3 sub-lines. Furthermore, adaptation to RITA was associated with fewer changes at the expression level of antiapoptotic factors than observed with adaptation to nutlin-3. Transcriptomic analyses indicated the RITA-adapted sub-lines to be more similar at the gene expression level to the parental UKF-NB-3 cells than nutlin-3-adapted UKF-NB-3 sub-lines, which correlates with the observed chemotherapy and irradiation sensitivity phenotypes. In conclusion, RITA-adapted cells retain functional p53, remain sensitive to nutlin-3, and display a less pronounced resistance phenotype than nutlin-3-adapted cells.

  3. Estado Nueva Esparta

    Directory of Open Access Journals (Sweden)

    Cecilia Bracho Toro

    2007-01-01

    Full Text Available Se diagnostica la situación actual de los conocimientos tradicionales de la palma datilera, sus derivados y su uso como atractivo turístico cultural del Municipio Díaz, Estado Nueva Esparta. Es un estudio descriptivo y de campo realizado específicamente en la comunidad de Fuentidueño, basado en entrevistas semi-estructuradas. Se concluye que la comunidad posee un cúmulo de conocimientos tradicionales, basados en saberes. Existe poca participación de las nuevas generaciones, en aprender los conocimientos tradicionales respecto al datilero y sus derivados. Se formulan recomendaciones: legales, educativos y comunitarias para la incorporación de los conocimientos tradicionales del datilero y sus derivados dentro de los atractivos turísticos culturales del Municipio.

  4. Proyecto Empresarial: Reto de la Universidad del Zulia para despertar el espíritu empresarial del estudiante e impulsar el desarrollo sustentable

    Directory of Open Access Journals (Sweden)

    Niria Quintero

    2004-09-01

    Full Text Available El crecimiento económico es un fenómeno social complejo, y existen muchas causas que pueden impulsarlo o frenarlo. En tal sentido, en la medida que los trabajadores de una economía sean ms productivos, su capacidad para crear riqueza ser mayor y por lo tanto la tasa de crecimiento económico tambin lo ser. Al respecto, la Universidad del Zulia, a travs de la Escuela de Administración y Contaduría Pública en la carrera de Administración asume en el eje profesional la asignatura Proyecto Empresarial, considerando la necesidad de hacerlos ms productivos como profesionales independientes, emprendedores, generadores de confianza y dispuestos a impulsar la relación productividad de trabajo-crecimiento económico. El presente estudio, describe la experiencia del programa de la asignatura Proyecto Empresarial, referida al Plan de Estudios de la Carrera de la Licenciatura en Administración, la cual se inicia en el año 2001. Se abordan las estrategias instruccionales, en el caso del rol del empresario como profesional Licenciado en Administración. La investigación es de tipo descriptivo, con la aplicación del cuestionario Plan de Negocios a una población constituida por estudiantes de la Licenciatura de Administración y a una muestra de los estudiantes cursantes de los períodos 2do. 2001 y 1ero. 2002 de la asignatura Proyecto Empresarial. Como resultado del trabajo se advierte, que en la medida que los profesionales de una economía sean ms productivos, intervengan con proyectos propios viables y promovidos por los gobiernos locales, estadales o nacionales, y enmarcados en los planes de la Nación se crean condiciones optimas para el desarrollo regional sustentable. En conclusión, la Universidad del Zulia a travs de la asignatura Proyecto Empresarial da respuesta al rol del empresario, con una concepción del libre ejercicio profesional que asume nuevos retos y cuyo propósito principal es desarrollar el potencial empresarial del

  5. Effects of hurricanes Katrina and Rita on the chemistry of bottom sediments in Lake Pontchartrain, Louisiana, USA

    Science.gov (United States)

    Van Metre, P.C.; Horowitz, A.J.; Mahler, B.J.; Foreman, W.T.; Fuller, C.C.; Burkhardt, M.R.; Elrick, K.A.; Furlong, E.T.; Skrobialowski, S.C.; Smith, J.J.; Wilson, J.T.; Zaugg, S.D.

    2006-01-01

    The effects of Hurricanes Katrina and Rita and the subsequent unwatering of New Orleans, Louisiana, on the sediment chemistry of Lake Pontchartrain were evaluated by chemical analysis of samples of street mud and suspended and bottom sediments. The highest concentrations of urban-related elements and compounds (e.g., Pb, Zn, polycyclic aromatic hydrocarbons, and chlordane) in bottom sediments exceeded median concentrations in U.S. urban lakes and sediment-quality guidelines. The extent of the elevated concentrations was limited, however, to within a few hundred meters of the mouth of the 17th Street Canal, similar to results of historical assessments. Chemical and radionuclide analysis of pre- and post-Hurricane Rita samples indicates that remobilization of near-shore sediment by lake currents and storms is an ongoing process. The effects of Hurricanes Katrina and Rita on the sediment chemistry of Lake Pontchartrain are limited spatially and are most likely transitory. ?? 2006 American Chemical Society.

  6. Aislamiento e identificación de microorganismos con potencial biofertilizante de suelos arroceros del distrito de riego del rio zulia, norte de santander

    Directory of Open Access Journals (Sweden)

    Marilyn Tatiana Santos-Torres

    2006-07-01

    Full Text Available It was evaluated the microbial population of soils cultivated with rice at some zones of the district of irrigation of Zulia River, Norte de Santander state, Colombia, and no cultivated soil with rice. It was found that the seeded soil with rice were significantly low in fungi, bacteria and actinomycete populations compa red with no seeded with rice. This situation was due to possibly excessive use of agricultural machine and excessive application of pesticides and continuous rice monoculture. Therefore, with use the biofertilizer enriched with microorganism isolated from zone with similar agroecological conditions, will improve the microorganism adaptation of the rizosphere and will promote a reestablishment of the biological balance of soils and therefore to increase biotic activity improving the quality and productivity of the cultures. A total of 43 bacteria and 4 fungi were isolated in different soils of the studied zone, and were identified 25 microorganisms. According the isolation methodology, the bacteria were separate in two groups: diazotrophic like the species of the genera Azotobacter sp., Azospirillum sp. and Beijerinckia sp. and the phosphate solubilizate inorganic like Bacillus megaterium, B. cereus, Pseudomonas putida and P. aeruginosa. For the fungi identification were evaluate the micro and macroscopic characteristics in the culture medium Czapeck, following the fungi keys of Samson Hoekstra and Oorsehot (1981, which allowed recognize species like Trichoderma sp., Aspergillus niger, Penicillium purpurogenum, P. pinopilum.

  7. Efecto del uso del suelo sobre rizobacterias fosfatosolubizadoras y diazotroficas en el distrito de riego del río zulia,norte de santander (colombia

    Directory of Open Access Journals (Sweden)

    Ronal Fernando-Cañon

    2009-07-01

    Full Text Available It was quantified the population of diazotrophic and phosphate solubilizer bacteria with the aim of determine the effect of the use of soils during different periods of intervention with culture of rice in three agro-ecological zones of the District of Irrigation of the Zulia river. The results showed that the management of the culture of rice in the different studied zones significantly influenced the population of microorganisms in all the studied culture media, excepting the semi-solid culture media JMV. The populations of the genera Azospirillum spp., Azotobacter spp., Beijerinckia spp., were influenced by the fertility of the soils in the zones of Buena Esperanza and Restauración compared with Limoncito, where the quantities of organic matter and nutritional escential elements were lower. It were obtained 28 isolations of entophytic, associative, free-living diazotrophic and phosphate solubilizer rhizobacteria according with their macroscopic characteristics in the culture media Batata, JMV, Ashby and nutritive, from the analysis of the population in the zones of Buena Esperanza, Restauración and Limoncito. These isolations were purified and preserved in sterilized saline solution (0.85% NaCl at 4°C in the Laboratory of Microbiology of the Colombian Agricultural Institute, ICA, with the purpose to be used in subsequent studies about their potential as biofertilizers in rice cultured soils of the department.

  8. Damage to offshore infrastructure in the Gulf of Mexico by hurricanes Katrina and Rita

    Science.gov (United States)

    Cruz, A. M.; Krausmann, E.

    2009-04-01

    The damage inflicted by hurricanes Katrina and Rita to the Gulf-of-Mexico's (GoM) oil and gas production, both onshore and offshore, has shown the proneness of industry to Natech accidents (natural hazard-triggered hazardous-materials releases). In order to contribute towards a better understanding of Natech events, we assessed the damage to and hazardous-materials releases from offshore oil and natural-gas platforms and pipelines induced by hurricanes Katrina and Rita. Data was obtained through a review of published literature and interviews with government officials and industry representatives from the affected region. We also reviewed over 60,000 records of reported hazardous-materials releases from the National Response Center's (NRC) database to identify and analyze the hazardous-materials releases directly attributed to offshore oil and gas platforms and pipelines affected by the two hurricanes. Our results show that hurricanes Katrina and Rita destroyed at least 113 platforms, and severely damaged at least 53 others. Sixty percent of the facilities destroyed were built 30 years ago or more prior to the adoption of the more stringent design standards that went into effect after 1977. The storms also destroyed 5 drilling rigs and severely damaged 19 mobile offshore drilling units (MODUs). Some 19 MODUs lost their moorings and became adrift during the storms which not only posed a danger to existing facilities but the dragging anchors also damaged pipelines and other infrastructure. Structural damage to platforms included toppling of sections, and tilting or leaning of platforms. Possible causes for failure of structural and non-structural components of platforms included loading caused by wave inundation of the deck. Failure of rigs attached to platforms was also observed resulting in significant damage to the platform or adjacent infrastructure, as well as damage to equipment, living quarters and helipads. The failures are attributable to tie-down components

  9. Lessons learned from the deadly sisters: drug and alcohol treatment disruption, and consequences from Hurricanes Katrina and Rita.

    Science.gov (United States)

    Maxwell, Jane Carlisle; Podus, Deborah; Walsh, David

    2009-01-01

    This paper reports on the effects of Hurricanes Katrina and Rita on drug and alcohol treatment in Texas in 2005-2006. Findings are based on a secondary analysis of administrative data on 567 hurricane-related admissions and on interview data from a sample of 20 staff in 11 treatment programs. Katrina evacuees differed from Rita clients in terms of demographics and primary problem substances and treatment needs, while the experiences of program staff and needed changes to improve disaster readiness were more similar. Additional systematic research is needed to document the intermediate and long-term impacts of the storms in these and other affected areas.

  10. Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma.

    Science.gov (United States)

    Saha, Manujendra N; Jiang, Hua; Yang, Yijun; Zhu, Xiaoyun; Wang, Xiaoming; Schimmer, Aaron D; Qiu, Lugui; Chang, Hong

    2012-01-01

    The low frequency of p53 alterations e.g., mutations/deletions (∼10%) in multiple myeloma (MM) makes this tumor type an ideal candidate for p53-targeted therapies. RITA is a small molecule which can induce apoptosis in tumor cells by activating the p53 pathway. We previously showed that RITA strongly activates p53 while selectively inhibiting growth of MM cells without inducing genotoxicity, indicating its potential as a drug lead for p53-targeted therapy in MM. However, the molecular mechanisms underlying the pro-apoptotic effect of RITA are largely undefined. Gene expression analysis by microarray identified a significant number of differentially expressed genes associated with stress response including c-Jun N-terminal kinase (JNK) signaling pathway. By Western blot analysis we further confirmed that RITA induced activation of p53 in conjunction with up-regulation of phosphorylated ASK-1, MKK-4 and c-Jun. These results suggest that RITA induced the activation of JNK signaling. Chromatin immunoprecipitation (ChIP) analysis showed that activated c-Jun binds to the activator protein-1 (AP-1) binding site of the p53 promoter region. Disruption of the JNK signal pathway by small interfering RNA (siRNA) against JNK or JNK specific inhibitor, SP-600125 inhibited the activation of p53 and attenuated apoptosis induced by RITA in myeloma cells carrying wild type p53. On the other hand, p53 transcriptional inhibitor, PFT-α or p53 siRNA not only inhibited the activation of p53 transcriptional targets but also blocked the activation of c-Jun suggesting the presence of a positive feedback loop between p53 and JNK. In addition, RITA in combination with dexamethasone, known as a JNK activator, displays synergistic cytotoxic responses in MM cell lines and patient samples. Our study unveils a previously undescribed mechanism of RITA-induced p53-mediated apoptosis through JNK signaling pathway and provides the rationale for combination of p53 activating drugs with JNK

  11. Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma.

    Directory of Open Access Journals (Sweden)

    Manujendra N Saha

    Full Text Available The low frequency of p53 alterations e.g., mutations/deletions (∼10% in multiple myeloma (MM makes this tumor type an ideal candidate for p53-targeted therapies. RITA is a small molecule which can induce apoptosis in tumor cells by activating the p53 pathway. We previously showed that RITA strongly activates p53 while selectively inhibiting growth of MM cells without inducing genotoxicity, indicating its potential as a drug lead for p53-targeted therapy in MM. However, the molecular mechanisms underlying the pro-apoptotic effect of RITA are largely undefined. Gene expression analysis by microarray identified a significant number of differentially expressed genes associated with stress response including c-Jun N-terminal kinase (JNK signaling pathway. By Western blot analysis we further confirmed that RITA induced activation of p53 in conjunction with up-regulation of phosphorylated ASK-1, MKK-4 and c-Jun. These results suggest that RITA induced the activation of JNK signaling. Chromatin immunoprecipitation (ChIP analysis showed that activated c-Jun binds to the activator protein-1 (AP-1 binding site of the p53 promoter region. Disruption of the JNK signal pathway by small interfering RNA (siRNA against JNK or JNK specific inhibitor, SP-600125 inhibited the activation of p53 and attenuated apoptosis induced by RITA in myeloma cells carrying wild type p53. On the other hand, p53 transcriptional inhibitor, PFT-α or p53 siRNA not only inhibited the activation of p53 transcriptional targets but also blocked the activation of c-Jun suggesting the presence of a positive feedback loop between p53 and JNK. In addition, RITA in combination with dexamethasone, known as a JNK activator, displays synergistic cytotoxic responses in MM cell lines and patient samples. Our study unveils a previously undescribed mechanism of RITA-induced p53-mediated apoptosis through JNK signaling pathway and provides the rationale for combination of p53 activating drugs with

  12. Dissolved and colloidal trace elements in the Mississippi River Delta outflow after Hurricanes Katrina and Rita

    Science.gov (United States)

    Shim, Moo-Joon; Swarzenski, Peter W.; Shiller, Alan M.

    2012-01-01

    The Mississippi River delta outflow region is periodically disturbed by tropical weather systems including major hurricanes, which can terminate seasonal bottom water hypoxia and cause the resuspension of shelf bottom sediments which could result in the injection of trace elements into the water column. In the summer of 2005, Hurricanes Katrina and Rita passed over the Louisiana Shelf within a month of each other. Three weeks after Rita, we collected water samples in the Mississippi River delta outflow, examining the distributions of trace elements to study the effect of Hurricanes Katrina and Rita. We observed limited stratification on the shelf and bottom waters that were no longer hypoxic. This resulted, for instance, in bottom water dissolved Mn being lower than is typically observed during hypoxia, but with concentrations still compatible with Mn–O2 trends previously reported. Interestingly, for no element were we able to identify an obvious effect of sediment resuspension on its distribution. In general, elemental distributions were compatible with previous observations in the Mississippi outflow system. Co and Re, which have not been reported for this system previously, showed behavior consistent with other systems: input for Co likely from desorption and conservative mixing for Re. For Cs, an element for which there is little information regarding its estuarine behavior, conservative mixing was also observed. Our filtration method, which allowed us to distinguish the dissolved (<0.02 μm) from colloidal (0.02–0.45 μm) phase, revealed significant colloidal fractions for Fe and Zn, only. For Fe, the colloidal phase was the dominant fraction and was rapidly removed at low salinity. Dissolved Fe, in contrast, persisted out to mid-salinities, being removed in a similar fashion to nitrate. This ability to distinguish the smaller Fe (likely dominantly organically complexed) from larger colloidal suspensates may be useful in better interpreting the

  13. The effect of proximity to hurricanes Katrina and Rita on subsequent hurricane outlook and optimistic bias.

    Science.gov (United States)

    Trumbo, Craig; Lueck, Michelle; Marlatt, Holly; Peek, Lori

    2011-12-01

    This study evaluated how individuals living on the Gulf Coast perceived hurricane risk after Hurricanes Katrina and Rita. It was hypothesized that hurricane outlook and optimistic bias for hurricane risk would be associated positively with distance from the Katrina-Rita landfall (more optimism at greater distance), controlling for historically based hurricane risk and county population density, demographics, individual hurricane experience, and dispositional optimism. Data were collected in January 2006 through a mail survey sent to 1,375 households in 41 counties on the coast (n = 824, 60% response). The analysis used hierarchal regression to test hypotheses. Hurricane history and population density had no effect on outlook; individuals who were male, older, and with higher household incomes were associated with lower risk perception; individual hurricane experience and personal impacts from Katrina and Rita predicted greater risk perception; greater dispositional optimism predicted more optimistic outlook; distance had a small effect but predicted less optimistic outlook at greater distance (model R(2) = 0.21). The model for optimistic bias had fewer effects: age and community tenure were significant; dispositional optimism had a positive effect on optimistic bias; distance variables were not significant (model R(2) = 0.05). The study shows that an existing measure of hurricane outlook has utility, hurricane outlook appears to be a unique concept from hurricane optimistic bias, and proximity has at most small effects. Future extension of this research will include improved conceptualization and measurement of hurricane risk perception and will bring to focus several concepts involving risk communication. © 2011 Society for Risk Analysis.

  14. Dissolved and colloidal trace elements in the Mississippi River delta outflow after Hurricanes Katrina and Rita

    Science.gov (United States)

    Shim, Moo-Joon; Swarzenski, Peter W.; Shiller, Alan M.

    2012-07-01

    The Mississippi River delta outflow region is periodically disturbed by tropical weather systems including major hurricanes, which can terminate seasonal bottom water hypoxia and cause the resuspension of shelf bottom sediments which could result in the injection of trace elements into the water column. In the summer of 2005, Hurricanes Katrina and Rita passed over the Louisiana Shelf within a month of each other. Three weeks after Rita, we collected water samples in the Mississippi River delta outflow, examining the distributions of trace elements to study the effect of Hurricanes Katrina and Rita. We observed limited stratification on the shelf and bottom waters that were no longer hypoxic. This resulted, for instance, in bottom water dissolved Mn being lower than is typically observed during hypoxia, but with concentrations still compatible with Mn-O2 trends previously reported. Interestingly, for no element were we able to identify an obvious effect of sediment resuspension on its distribution. In general, elemental distributions were compatible with previous observations in the Mississippi outflow system. Co and Re, which have not been reported for this system previously, showed behavior consistent with other systems: input for Co likely from desorption and conservative mixing for Re. For Cs, an element for which there is little information regarding its estuarine behavior, conservative mixing was also observed. Our filtration method, which allowed us to distinguish the dissolved (<0.02 μm) from colloidal (0.02-0.45 μm) phase, revealed significant colloidal fractions for Fe and Zn, only. For Fe, the colloidal phase was the dominant fraction and was rapidly removed at low salinity. Dissolved Fe, in contrast, persisted out to mid-salinities, being removed in a similar fashion to nitrate. This ability to distinguish the smaller Fe (likely dominantly organically complexed) from larger colloidal suspensates may be useful in better interpreting the bioavailablity

  15. Rita Thalmann (1926-2013), Pioneer of Women’s History

    OpenAIRE

    Hoock-Demarle, Marie-Claire

    2017-01-01

    Born in Nuremberg to a German-Jewish father and a Swiss-Jewish mother, Rita Thalmann fled the Nazi regime with her family in 1933, first taking refuge in Switzerland and then in France. After losing both her father (denounced and deported to Auschwitz), and her mother (who died of malnutrition while interned in Dijon), she survived the war through a support network organized by the headmistress of Dijon’s girls’ lycée, Marcelle Pardé, a member of the Resistance later deported to Ravensbrück. ...

  16. External factors impacting hospital evacuations caused by Hurricane Rita: the role of situational awareness.

    Science.gov (United States)

    Downey, Erin L; Andress, Knox; Schultz, Carl H

    2013-06-01

    The 2005 Gulf Coast hurricane season was one of the most costly and deadly in US history. Hurricane Rita stressed hospitals and led to multiple, simultaneous evacuations. This study systematically identified community factors associated with patient movement out of seven hospitals evacuated during Hurricane Rita. This study represents the second of two systematic, observational, and retrospective investigations of seven acute care hospitals that reported off-site evacuations due to Hurricane Rita. Participants from each hospital included decision makers that comprised the Incident Management Team (IMT). Investigators applied a standardized interview process designed to assess evacuation factors related to external situational awareness of community activities during facility evacuation due to hurricanes. The measured outcomes were responses to 95 questions within six sections of the survey instrument. Investigators identified two factors that significantly impacted hospital IMT decision making: (1) incident characteristics affecting a facility's internal resources and challenges; and (2) incident characteristics affecting a facility's external evacuation activities. This article summarizes the latter and reports the following critical decision making points: (1) Emergency Operations Plans (EOP) were activated an average of 85 hours (3 days, 13 hours) prior to Hurricane Rita's landfall; (2) the decision to evacuate the hospital was made an average of 30 hours (1 day, 6 hours) from activation of the EOP; and (3) the implementation of the evacuation process took an average of 22 hours. Coordination of patient evacuations was most complicated by transportation deficits (the most significant of the 11 identified problem areas) and a lack of situational awareness of community response activities. All evacuation activities and subsequent evacuation times were negatively impacted by an overall lack of understanding on the part of hospital staff and the IMT regarding how to

  17. Inelastic neutron scattering experiments with the monochromatic imaging mode of the RITA-II spectrometer

    International Nuclear Information System (INIS)

    Bahl, C.R.H.; Lefmann, K.; Abrahamsen, A.B.; Ronnow, H.M.; Saxild, F.; Jensen, T.B.S.; Udby, L.; Andersen, N.H.; Christensen, N.B.; Jakobsen, H.S.; Larsen, T.; Haefliger, P.S.; Streule, S.; Niedermayer, Ch.

    2006-01-01

    Recently a monochromatic multiple data taking mode has been demonstrated for diffraction experiments using a RITA type cold neutron spectrometer with a multi-bladed analyser and a position-sensitive detector. Here, we show how this mode can be used in combination with a flexible radial collimator to perform real inelastic neutron scattering experiments. We present the results from inelastic powder, single crystal dispersion and single crystal constant energy mapping experiments. The advantages and complications of performing these experiments are discussed along with a comparison between the imaging mode and the traditional monochromatic focussing mode

  18. Inelastic neutron scattering experiments with the monochromatic imaging mode of the RITA-II spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Bahl, C.R.H. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark) and Department of Physics, Technical University of Denmark, DK-2800 Lyngby (Denmark)]. E-mail: christian.bahl@risoe.dk; Lefmann, K. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark)]. E-mail: kim.lefmann@risoe.dk; Abrahamsen, A.B. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Ronnow, H.M. [Laboratory for Neutron Scattering, Paul Scherrer Institute, CH-5232 Villigen (Switzerland); Saxild, F. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Jensen, T.B.S. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Udby, L. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Andersen, N.H. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Christensen, N.B. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Laboratory for Neutron Scattering, Paul Scherrer Institute, CH-5232 Villigen (Switzerland); Jakobsen, H.S. [Niels Bohr Institute for Astronomy, Physics and Geophysics, University of Copenhagen, DK-2100 Copenhagen (Denmark); Larsen, T. [Niels Bohr Institute for Astronomy, Physics and Geophysics, University of Copenhagen, DK-2100 Copenhagen (Denmark); Haefliger, P.S. [Laboratory for Neutron Scattering, Paul Scherrer Institute, CH-5232 Villigen (Switzerland); Streule, S.; Niedermayer, Ch. [Laboratory for Neutron Scattering, Paul Scherrer Institute, CH-5232 Villigen (Switzerland)

    2006-05-15

    Recently a monochromatic multiple data taking mode has been demonstrated for diffraction experiments using a RITA type cold neutron spectrometer with a multi-bladed analyser and a position-sensitive detector. Here, we show how this mode can be used in combination with a flexible radial collimator to perform real inelastic neutron scattering experiments. We present the results from inelastic powder, single crystal dispersion and single crystal constant energy mapping experiments. The advantages and complications of performing these experiments are discussed along with a comparison between the imaging mode and the traditional monochromatic focussing mode.

  19. The RITA spectrometer at Risø - Design considerations and recent results

    DEFF Research Database (Denmark)

    Clausen, K.N.; McMorrow, D.F.; Lefmann, K.

    1998-01-01

    In the new cold triple axis spectrometer RITA at Riso we have improved the front end by extensive use of state of the art optical elements and better shielding material. The analyser system is situated in one large open tank and consists of seven individually orientable PC(002) crystal analyser b...... by a study of the spin fluctuations in the high T-c superconductor La1.83Sr0.17CuO4. (C) 1998 Elsevier Science B.V. All rights reserved....

  20. Mochima, estado Sucre (Venezuela

    Directory of Open Access Journals (Sweden)

    Karen Elisa Requena Mago

    2005-01-01

    Full Text Available En tiempos de recesión, los expertos nos bombardean con cifras relacionadas a la caída del producto interno bruto, al desempleo, entre otras. Dada la situación que presenta hoy en día Venezuela, aunado a la alta inflación y la devaluación de la moneda; el escenario resulta bastante complicado para el consumidor y las empresas proveedoras de bienes y servicios. En este sentido, las PyMES turísticas de Mochima, ubicadas en el Estado Sucre, Venezuela, se presentan como una alternativa para de alguna manera ayudar a disipar ese triste escenario, mediante sus bondades y en combinación con Internet. De allí que el presente artículo aborde desde los aspectos teóricos del turismo hasta las bondades naturales y culturales que ofrece esta zona oriental del país. Se utilizó una metodología de carácter descriptiva y una combinación de estrategia documental y de campo. Se aplicó un muestreo no probabilístico de tipo intencional, seleccionando los elementos con base en criterios de los investigadores. De acuerdo al estudio, se diseñó la página web y se concluyó, que la implementación de la misma ayudaría en gran medida a mejorar los ingresos de la región y darse a conocer tanto a nivel nacional como internacional.

  1. Estado Nutricional del Yodo.

    Directory of Open Access Journals (Sweden)

    Hernando Vargas Uricoechea

    2015-06-01

    Full Text Available INTRODUCCIÓN: Los Desórdenes por Deficiencia de Yodo son un problema serio de salud pública, con cerca de 2 mil millones de personas a riesgo de padecerlos, pudiendo causar bocio neonatal, cretinismo, retardo mental, hipotiroidismo, entre otros. Estos desórdenes son aún prevalentes, y en algunos casos los esfuerzos para su erradicación se han traducido en aumento del riesgo de exceso poblacional de yodo y autoinmunidad tiroidea. En Colombia, se desconoce el estado real de yodo en la población. OBJETIVOS: Determinar la mediana de la yoduría en población escolar, y de los hábitos del consumo de sal, función y parámetros de autoinmunidad tiroidea, y cociente intelectual. MATERIALES Y MÉTODOS: Estudio basado en la comunidad, de corte transversal. Se evaluaron las variables sociodemográficas, la frecuencia de bocio y los niveles de TSH, anti-TPO, anti-Tg, anti-TSHR, yoduria, test de factor G de Cattell, y hábitos del consumo de sal. RESULTADOS: El consumo de sal promedio persona/día fue de 18,13 g. El 37,9% presentó bocio. 36,1% tenían un valor límite en el cociente intelectual. La mediana de yoduria fue de 510,3 μg/L. El 42,75% tuvo anti-TPO positivos, y el 2,87% anti-Tg positivos. El 10% presentó niveles de TSH elevados. CONCLUSIÓN: En escolares de zona urbana, hay un exceso en la mediana de yoduria, pudiendo explicarse por el alto consumo de sal. La alta prevalencia de autoinmunidad tiroidea y bocio, junto al alto nivel de la TSH, puede ser consecuencia del exceso en la ingesta de sal y de otros factores medioambientales/ hereditarios.

  2. Floristic composition of the cerrado in the Pé-de-Gigante Reserve (Santa Rita do Passa Quatro, southeastern Brazil Composição florística do cerrado na Reserva Pé-de-Gigante (Santa Rita do Passa Quatro, SP

    Directory of Open Access Journals (Sweden)

    Marco Antônio Batalha

    2001-12-01

    Full Text Available We studied a 1225 ha area, composed mainly of cerrado, in Santa Rita do Passa Quatro, São Paulo State, southeastern Brazil (21°36-38'S, 47°36-39'W. In three cerrado physiognomies (campo cerrado -- a wooded savanna, cerrado sensu stricto -- a woodland, and cerradão -- a tall woodland, we collected all vascular plants in reproductive stage, and identified them to species level. We found 360 species, representing 236 genera and 69 families. The richest families were: Asteraceae, Fabaceae, Poaceae, and Rubiaceae. The savanna physiognomies were richer than the forest one. The ratio between herbaceous and woody species was approximately 2:1. We analysed the whole flora and its two components separately, woody and herbaceous, comparing them with other disjunct cerrado areas. We obtained similarity values (Sørensen index from 0.47 to 0.81, which showed that the 3 diversity of the cerrado was higher in the herbaceous component than in the woody one.Estudamos uma área de 1225 ha, composta principalmente por cerrado, situada em Santa Rita do Passa Quatro, estado de São Paulo (21°36-38'S, 47°36-39'W. Em três fisionomias de cerrado (campo cerrado, cerrado sensu stricto e cerradão, coletamos, durante 18 meses, em excursões mensais, espécimes em fase fértil e os identificamos em nível específico. Encontramos 360 espécies, pertencentes a 236 gêneros e 69 famílias. As fam��lias mais ricas foram: Fabaceae, Asteraceae, Poaceae e Rubiaceae. As fisionomias savânicas foram mais ricas do que a florestal. A razão entre espécies arbustivo-arbóreas e herbáceo-subarbustivas foi de aproximadamente 2:1. Analisamos a flora como um todo e seus componentes herbáceo-subarbustivo e arbustivo-arbóreo separadamente, comparando-os com outras áreas disjuntas de cerrado. Dessa comparação, obtivemos valores de similaridade (índice de Sørensen de 0,47 a 0,81, que mostraram que a diversidade 3 foi maior no componente herbáceo-subarbustivo do que no

  3. RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses.

    Science.gov (United States)

    Saha, Manujendra N; Jiang, Hua; Mukai, Asuka; Chang, Hong

    2010-11-01

    Mutations or deletions of p53 are relatively rare in multiple myeloma (MM), at least in newly diagnosed patients. Thus, restoration of p53 tumor suppressor function in MM by blocking the inhibitory role of murine double minute 2 (MDM2) is a promising and applicable therapeutic strategy. RITA and nutlin are two new classes of small molecule MDM2 inhibitors that prevent the p53-MDM2 interaction. Earlier reports showed p53-dependent activity of RITA in solid tumors as well as in leukemias. We and others recently described nutlin-induced apoptosis in MM cells, but it remains unclear whether RITA exerts antimyeloma activity. Here, we found that RITA activates the p53 pathway and induces apoptosis in MM cell lines and primary MM samples, preferentially killing myeloma cells. The activation of p53 induced by RITA was mediated through modulation of multiple apoptotic regulatory proteins, including upregulation of a proapoptotic protein (NOXA), downregulation of an antiapoptotic protein, Mcl-1, and activation of caspases through extrinsic pathways. Moreover, a number of key p53-mediated apoptotic target genes were identified by gene expression profiling and further validated by quantitative real-time PCR. Importantly, the combination of RITA with nutlin displayed a strong synergism on growth inhibition with the combination index ranging from 0.56 to 0.82 in MM cells. Our data support further clinical evaluation of RITA as a potential novel therapeutic intervention in MM. ©2010 AACR.

  4. Environmental Impact Report from Santa Rita Hydroelectric Power Plant (Minas Gerais State - Brazil): technical strategic for its elaboration; Relatorio de Impacto Ambiental da Usina Hidreletrica da Santa Rita (MG): estrategica tecnica para sua elaboracao

    Energy Technology Data Exchange (ETDEWEB)

    Souza, J.A. de; Marques Neto, F P [Companhia Energetica de Minas Gerais (CEMIG), Belo Horizonte, MG (Brazil)

    1990-12-31

    The steps for developing the technical strategies used on the elaboration of Environmental Impact Report from Santa Rita Hydroelectric Power Plant, Minas Gerais State, are described, including the influence area, technical requirements, impact identification, technical selection of mitigative measures, impact meaning and strategy for evaluating the identified impacts. (C.G.C.).

  5. Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.

    Science.gov (United States)

    Tabaja, Nassif; Yuan, Zhenyu; Oswald, Franz; Kovall, Rhett A

    2017-06-23

    The Notch pathway is a cell-to-cell signaling mechanism that is essential for tissue development and maintenance, and aberrant Notch signaling has been implicated in various cancers, congenital defects, and cardiovascular diseases. Notch signaling activates the expression of target genes, which are regulated by the transcription factor CSL (CBF1/RBP-J, Su(H), Lag-1). CSL interacts with both transcriptional corepressor and coactivator proteins, functioning as both a repressor and activator, respectively. Although Notch activation complexes are relatively well understood at the structural level, less is known about how CSL interacts with corepressors. Recently, a new RBP-J (mammalian CSL ortholog)-interacting protein termed RITA has been identified and shown to export RBP-J out of the nucleus, thereby leading to the down-regulation of Notch target gene expression. However, the molecular details of RBP-J/RITA interactions are unclear. Here, using a combination of biochemical/cellular, structural, and biophysical techniques, we demonstrate that endogenous RBP-J and RITA proteins interact in cells, map the binding regions necessary for RBP-J·RITA complex formation, and determine the X-ray structure of the RBP-J·RITA complex bound to DNA. To validate the structure and glean more insights into function, we tested structure-based RBP-J and RITA mutants with biochemical/cellular assays and isothermal titration calorimetry. Whereas our structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J. Taken together, these results provide molecular insights into the mechanism of RITA-mediated regulation of Notch signaling, contributing to our understanding of how CSL functions as a transcriptional repressor of Notch target genes. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  6. saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription.

    Science.gov (United States)

    Portnoy, Victoria; Lin, Szu Hua Sharon; Li, Kathy H; Burlingame, Alma; Hu, Zheng-Hui; Li, Hao; Li, Long-Cheng

    2016-03-01

    Small activating RNAs (saRNAs) targeting specific promoter regions are able to stimulate gene expression at the transcriptional level, a phenomenon known as RNA activation (RNAa). It is known that RNAa depends on Ago2 and is associated with epigenetic changes at the target promoters. However, the precise molecular mechanism of RNAa remains elusive. Using human CDKN1A (p21) as a model gene, we characterized the molecular nature of RNAa. We show that saRNAs guide Ago2 to and associate with target promoters. saRNA-loaded Ago2 facilitates the assembly of an RNA-induced transcriptional activation (RITA) complex, which, in addition to saRNA-Ago2 complex, includes RHA and CTR9, the latter being a component of the PAF1 complex. RITA interacts with RNA polymerase II to stimulate transcription initiation and productive elongation, accompanied by monoubiquitination of histone 2B. Our results establish the existence of a cellular RNA-guided genome-targeting and transcriptional activation mechanism and provide important new mechanistic insights into the RNAa process.

  7. Secondary eyewall formation in WRF simulations of Hurricanes Rita and Katrina (2005)

    Science.gov (United States)

    Abarca, Sergio F.; Corbosiero, Kristen L.

    2011-04-01

    An analysis is presented of two high-resolution hurricane simulations of Katrina and Rita (2005) that exhibited secondary eyewall formation (SEF). The results support the notion of vortex Rossby waves (VRWs) having an important role in SEF and suggest that VRW activity is a defining aspect of the moat. SEF occurs at a radius of ˜65 (80) km in Katrina (Rita), close to the hypothesized stagnation radius of VRWs. VRW activity appears to be the result of eye-eyewall mixing events, themselves a product of the release of barotropic instability. The convection in the radial region that becomes the moat is mainly in the form of VRWs propagating radially outward from the primary eyewall until the negative radial gradient of potential vorticity is no longer conducive for their propagation. These convectively coupled waves, originating and being expelled from the eyewall, are rotation dominated and have the coherency necessary to survive their passage through the strain-dominated region outside the eyewall.

  8. From the incident command center oil spills from Hurricanes Katrina and Rita

    Energy Technology Data Exchange (ETDEWEB)

    Guidry, R.J. [Lousiana Oil Spill Coordinator' s Office, Baton Rouge, LA (United States)

    2006-07-01

    Approximately 30.2 million litres of oil were discharged during Hurricanes Katrina and Rita. A total of 230 incidents were reported to the state's spill response community, including ruptured pipelines, damaged and moved storage tanks, refineries, and sunken vessels. By January 2006, industry had reported the recovery of 14.7 million litres of oil. After Hurricane Rita, a further 234 off- and onshore incidents were reported. This paper presented a chronology from August 26 2005 through to June 2006 of clean-up activities for both hurricanes, with specific reference to logistic and communications issues associated with working in environments that are difficult to access due to damaged transportation infrastructure. An outline of the Louisiana Oil Spill Coordinator's Office's role in the incidents was presented, as well as an overview of the Louisiana State Contingency Plan. It was noted that the lack of communications systems caused considerable difficulties for responders. It was concluded that responses to hurricanes can be made more effective by having all response communities incident command structure (ICS)-trained with a thorough knowledge of the National Response Plan as it relates to the National Contingency Plan. Ensuring that plans are operational, having clear lines of authority on all hurricane-related issues, and having a robust communications plan were recommended, as well as the ability to respond without communications.

  9. The RITA spectrometer at Risø - design considerations and recent results

    Science.gov (United States)

    Clausen, K. N.; McMorrow, D. F.; Lefmann, K.; Aeppli, G.; Mason, T. E.; Schröder, A.; Issikii, M.; Nohara, M.; Takagi, H.

    In the new cold triple axis spectrometer RITA at Risø we have improved the front end by extensive use of state of the art optical elements and better shielding material. The analyser system is situated in one large open tank and consists of seven individually orientable PG(002) crystal analyser blades, and a 170 mm by 120 mm 2 areas sensitive micro-strip detector. In comparison to the old TAS6 spectrometer we have obtained a factor 2-5 gain in intensity on the sample, a substantially lower background, much more flexibility for optimising the instrument and the possibility to go beyond simple point-by-point inspection. The excellent performance of RITA in the standard TAS mode is exemplified by a study of the dynamics of ≈ 15 nm hematite (α-Fe 2O 3) nano-particles, and utilisation of horizontal and vertical focusing modes to study two dimensional systems is illustrated by a study of the spin fluctuations in the high Tc superconductor La 1.83Sr 0.17CuO 4.

  10. From the incident command center oil spills from Hurricanes Katrina and Rita

    International Nuclear Information System (INIS)

    Guidry, R.J.

    2006-01-01

    Approximately 30.2 million litres of oil were discharged during Hurricanes Katrina and Rita. A total of 230 incidents were reported to the state's spill response community, including ruptured pipelines, damaged and moved storage tanks, refineries, and sunken vessels. By January 2006, industry had reported the recovery of 14.7 million litres of oil. After Hurricane Rita, a further 234 off- and onshore incidents were reported. This paper presented a chronology from August 26 2005 through to June 2006 of clean-up activities for both hurricanes, with specific reference to logistic and communications issues associated with working in environments that are difficult to access due to damaged transportation infrastructure. An outline of the Louisiana Oil Spill Coordinator's Office's role in the incidents was presented, as well as an overview of the Louisiana State Contingency Plan. It was noted that the lack of communications systems caused considerable difficulties for responders. It was concluded that responses to hurricanes can be made more effective by having all response communities incident command structure (ICS)-trained with a thorough knowledge of the National Response Plan as it relates to the National Contingency Plan. Ensuring that plans are operational, having clear lines of authority on all hurricane-related issues, and having a robust communications plan were recommended, as well as the ability to respond without communications

  11. Mental Health, Substance Use, and Adaptive Coping among Social Work Students in the Aftermath of Hurricanes Katrina and Rita

    Science.gov (United States)

    Lemieux, Catherine M.; Plummer, Carol A.; Richardson, Roslyn; Simon, Cassandra E.; Ai, Amy L.

    2010-01-01

    The current study examined mental health symptomology, substance use, and adaptive coping among 416 social work students following Hurricanes Katrina and Rita. Among participants, 47% scored at or above the clinical level for depression, with 6% of students showing clinical PTSD-like symptoms, and 16.9% reporting substance use. Two thirds (66.9%)…

  12. Meie seast on lahkunud saksa keele tõlk Rita Tasa : [3.12.1930-16.07.2007

    Index Scriptorium Estoniae

    2007-01-01

    Järelhüüe kirjandusteadlasele, Tartu Ülikooli saksa kirjanduse õppejõule, Tallinna Pedagoogilise Instituudi saksa ja maailmakirjanduse õppejõule, saksa keele kadeedri juhatajale, saksa, šveitsi ning austria kirjanduse tõlkijale Rita Tasale

  13. Environmental Impact Report from Santa Rita Hydroelectric Power Plant (Minas Gerais State - Brazil): technical strategic for its elaboration

    International Nuclear Information System (INIS)

    Souza, J.A. de; Marques Neto, F.P.

    1989-01-01

    The steps for developing the technical strategies used on the elaboration of Environmental Impact Report from Santa Rita Hydroelectric Power Plant, Minas Gerais State, are described, including the influence area, technical requirements, impact identification, technical selection of mitigative measures, impact meaning and strategy for evaluating the identified impacts. (C.G.C.)

  14. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation.

    Science.gov (United States)

    Zhao, Carolyn Ying; Szekely, Laszlo; Bao, Wenjie; Selivanova, Galina

    2010-04-15

    Proteasomal degradation of p53 by human papilloma virus (HPV) E6 oncoprotein plays a pivotal role in the survival of cervical carcinoma cells. Abrogation of HPV-E6-dependent p53 destruction can therefore be a good strategy to combat cervical carcinomas. Here, we show that a small-molecule reactivation of p53 and induction of tumor cell apoptosis (RITA) is able to induce the accumulation of p53 and rescue its tumor suppressor function in cells containing high-risk HPV16 and HPV18 by inhibiting HPV-E6-mediated proteasomal degradation. RITA blocks p53 ubiquitination by preventing p53 interaction with E6-associated protein, required for HPV-E6-mediated degradation. RITA activates the transcription of proapoptotic p53 targets Noxa, PUMA, and BAX, and repressed the expression of pro-proliferative factors CyclinB1, CDC2, and CDC25C, resulting in p53-dependent apoptosis and cell cycle arrest. Importantly, RITA showed substantial suppression of cervical carcinoma xenografts in vivo. These results provide a proof of principle for the treatment of cervical cancer in a p53-dependent manner by using small molecules that target p53. (c)2010 AACR.

  15. Traumatic Loss and Natural Disaster: A Case Study of a School-Based Response to Hurricanes Katrina and Rita

    Science.gov (United States)

    Clettenberg, Stacey; Gentry, Judy; Held, Matthew; Mock, Lou Ann

    2011-01-01

    This article tracks the trajectory and impact of Hurricanes Katrina and Rita on the communities of Houston/Harris County, Texas, USA, the schools, children, and families; along with the community partnerships that addressed the trauma and upheaval. Following the influx of individuals and families who were displaced by Hurricanes Katrina and Rita…

  16. Positive Traits versus Previous Trauma: Racially Different Correlates with PTSD Symptoms among Hurricane Katrina-Rita Volunteers

    Science.gov (United States)

    Ai, Amy L.; Plummer, Carol; Kanno, Hanae; Heo, Grace; Appel, Hoa B.; Simon, Cassandra E.; Spigner, Clarence

    2011-01-01

    This study compared risks and protective factors for acquiring symptoms of posttraumatic stress disorder (PTSD) between African-American (n = 299) and European-American (n = 206) student volunteers 3 months after Hurricanes Katrina and Rita (H-KR). Respondents retrospectively provided information on peritraumatic emotional reactions and previous…

  17. Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer

    Directory of Open Access Journals (Sweden)

    Espinoza-Fonseca L Michel

    2005-09-01

    Full Text Available Abstract Background The use of low-molecular-weight, non-peptidic molecules that disrupt the interaction between the p53 tumor suppressor and its negative regulator MDM2 has provided a promising alternative for the treatment of different types of cancer. Among these compounds, RITA (reactivation of p53 and induction of tumor cell apoptosis has been shown to be effective in the selective induction of apoptosis, and this effect is due to its binding to the p53 tumor suppressor. Since biological systems are highly dynamic and MDM2 may bind to different regions of p53, new alternatives should be explored. On this basis, the computational "blind docking" approach was employed in this study to see whether RITA would bind to MDM2. Results It was observed that RITA binds to the MDM2 p53 transactivation domain-binding cleft. Thus, RITA can be used as a lead compound for designing improved "multi-target" drugs. This novel strategy could provide enormous benefits to enable effective anti-cancer strategies. Conclusion This study has demonstrated that a single molecule can target at least two different proteins related to the same disease.

  18. Rising Above the Water: New Orleans Implements Energy Efficiency and Sustainability Practices Following Hurricanes Katrina and Rita (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2012-07-01

    This fact sheet describes the technical assistance that the U.S. Department of Energy, through its National Renewable Energy Laboratory, provided to New Orleans, Louisiana, which helped the city incorporate energy efficiency into its rebuilding efforts for K-12 schools and homes following Hurricanes Katrina and Rita. NREL also provided support and analysis on energy policy efforts.

  19. RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38.

    Science.gov (United States)

    Weilbacher, A; Gutekunst, M; Oren, M; Aulitzky, W E; van der Kuip, H

    2014-07-10

    Significant advances have been made in the development of small molecules blocking the p53/MDM2 interaction. The Mdm2 inhibitor Nutlin-3 is restricted to tumors carrying wtp53. In contrast, RITA, a compound that binds p53, has recently been shown also to restore transcriptional functions of mtp53. As more than 50% of solid tumors carry p53 mutations, RITA promises to be a more effective therapeutic strategy than Nutlin-3. We investigated effects of RITA on apoptosis, cell cycle and induction of 45 p53 target genes in a panel of 14 cell lines from different tumor entities with different p53 status as well as primary lymphocytes and fibroblasts. Nine cell strains expressed wtp53, four harbored mtp53, and three were characterized by the loss of p53 protein. A significant induction of cell death upon RITA was observed in 7 of 16 cell lines. The nonmalignant cells in our panel were substantially less sensitive. We found that in contrast to Nultin-3, RITA is capable to induce cell death not only in tumor cells harboring wtp53 and mtp53 but also in p53-null cells. Importantly, whereas p53 has a central role for RITA-mediated effects in wtp53 cells, neither p53 nor p63 or p73 were essential for the RITA response in mtp53 or p53-null cells in our panel demonstrating that besides the known p53-dependent action of RITA in wtp53 cells, RITA can induce cell death also independently of p53 in cells harboring defective p53. We identified an important role of both p38 and JNK/SAPK for sensitivity to RITA in these cells leading to a typical caspase- and BAX/BAK-dependent mitochondrial apoptosis. In conclusion, our data demonstrate that RITA can induce apoptosis through p38 and JNK/SAPK not only in tumor cells harboring wtp53 and mtp53 but also in p53-null cells, making RITA an interesting tumor-selective drug.

  20. EXPECTATIVAS DE LOS ESTUDIANTES DEL PROGRAMA INGENIERÍA NÚCLEO COSTA ORIENTAL DEL LAGO DE LA UNIVERSIDAD DEL ZULIA CON RELACIÓN AL TRABAJO

    Directory of Open Access Journals (Sweden)

    Egilde Zambrano

    2011-11-01

    Full Text Available La investigación tuvo como propósito determinar las expectativas de los estudiantes próximos a egresar del Programa de Ingeniería de la Universidad del Zulia, Núcleo Costa Oriental del Lago con relación al trabajo, en virtud de que proveerá a las investigadoras de información útil para anticipar cómo asumirían éstos su rol profesional, tomando en cuenta que será la etapa a la que dedicarán el mayor tiempo de sus vidas productivas. Teóricamente se fundamenta en los aportes de Barriguete (1994, García y García (2000, Zácares y Llinares (2006 y Hellriegel y Slocum (2009, entre otros. La investigación es descriptiva con diseño no experimental, ex post facto, transeccional y de campo. La población la conformaron 97 estudiantes del último bienio correspondientes al primer y segundo período 2008, a quienes se les aplicó un cuestionario. Entre los resultados destacan: 85% se visualiza como un profesional exitoso, 100% logrará sus objetivos profesionales con alto desempeño, 59% piensa que no hay un empleo específico para ser reconocido como exitoso, 86% espera ejercer una vez graduado. Se concluye que las expectativas son positivas y que ello influirá en una mayor posibilidad de enfrentar exitosamente el reto laboral.

  1. Dinámica de la economía agroexportadora de Zulia con la explotación petrolera en Venezuela (1914-1935

    Directory of Open Access Journals (Sweden)

    Nilda Bermúdez Briñez

    2012-04-01

    Full Text Available El artículo aborda el proceso histórico del circuito agroexportador marabino en el occidente de Venezuela, y su fortalecimiento durante las primeras décadas del siglo XX generado por la incorporación de la explotación petrolera que dinamizó el comercio de la región, debilitado en la última etapa de la década de 1890. Durante esta coyuntura, la nueva actividad minera actuó como elemento dinamizador del centro mercantil lacustre debido al incremento de los negocios de criollos y extranjeros que lograron reactivar el comercio de importación de bienes y servicios al acentuarse la demanda local. El método histórico permitió la identificación de los factores que intervinieron en la reactivación económica y la explicación del proceso de reacomodo que se dio en el circuito, a través de la información que aportaron las diversas fuentes analizadas.The article pretends to approach the historical process of the Maracaibo's agricultural exporting circuit during the first decades of XX century and its strengthening generated by the incorporation of the petroleum exploitation that stirred the Zulia's trade debilitated in the last stage of the nineties. During this conjuncture, the new mining activity acted as a revitalizing and of integration element of the lacustrine mercantile center due to the increase of the business of creoles and foreigners who managed to reactivate the trade of import on having invested the capitals in goods and services with local, regional and international demand. In the investigation it was used the historical method that allowed the identification of the factors that intervened in the process of rearrangement that was given in the circuit across the information that the diverse analyzed sources contributed.

  2. A randomized comparison of the Saphenous Vein Versus Right Internal Thoracic Artery as a Y-Composite Graft (SAVE RITA) trial: One-year angiographic results and mid-term clinical outcomes.

    Science.gov (United States)

    Kim, Ki-Bong; Hwang, Ho Young; Hahn, Seokyung; Kim, Jun Sung; Oh, Se Jin

    2014-09-01

    The Saphenous Vein Versus Right Internal Thoracic Artery as a Y-Composite Graft (SAVE RITA) trial was designed to evaluate the noninferiority of the saphenous vein (SV) compared with the right internal thoracic artery ([R]ITA) used as a Y-composite graft. A total of 224 patients who had undergone off-pump revascularization for multivessel coronary artery disease using the SV or RITA as a Y-composite graft based on the in situ left ITA were assigned randomly to the SV Y-composite graft (SV group, n = 112) or free RITA Y-composite graft (RITA group, n = 112). The primary endpoint was the 1-year angiographic patency rate of the second limb conduits (SV or RITA). Postoperative 1-year coronary angiograms were performed in 215 patients (SV group, 108; RITA group, 107). The overall graft patency rate was 97.4% (745 of 765) at 1 year (97.9% in the SV group vs 96.9% in the RITA group, P = .362). The primary endpoint of the study, the 1-year patency rate of the SV composite grafts, was 97.1% (238 of 245) and was noninferior to that of the RITA composite grafts (97.1% [198 of 204]) with a 95% lower confidence limit of -2.6% (P RITA composite grafts in terms of the 1-year angiographic patency rates. Copyright © 2014 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

  3. p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA.

    Science.gov (United States)

    Hedström, Elisabeth; Eriksson, Sofi; Zawacka-Pankau, Joanna; Arnér, Elias S J; Selivanova, Galina

    2009-11-01

    Thioredoxin reductase 1 (TrxR1) is a key regulator in many redox-dependent cellular pathways, and is often overexpressed in cancer. Several studies have identified TrxR1 as a potentially important target for anticancer therapy. The low molecular weight compound RITA (NSC 652287) binds p53 and induces p53-dependent apoptosis. Here we found that RITA also targets TrxR1 by non-covalent binding, followed by inhibition of its activity in vitro and by inhibition of TrxR activity in cancer cells. Interestingly, a novel approximately 130 kDa form of TrxR1, presumably representing a stable covalently linked dimer, and an increased generation of reactive oxygen species (ROS) were induced by RITA in cancer cells in a p53-dependent manner. Similarly, the gold-based TrxR inhibitor auranofin induced apoptosis related to oxidative stress, but independently of p53 and without apparent induction of the approximately 130 kDa form of TrxR1. In contrast to the effects observed in cancer cells, RITA did not inhibit TrxR or ROS formation in normal fibroblasts (NHDF). The inhibition of TrxR1 can sensitize tumor cells to agents that induce oxidative stress and may directly trigger cell death. Thus, our results suggest that a unique p53-dependent effect of RITA on TrxR1 in cancer cells might synergize with p53-dependent induction of pro-apoptotic genes and oxidative stress, thereby leading to a robust induction of cancer cell death, without affecting non-transformed cells.

  4. Application of Geographic Information Systems for Rural Electrification with Renewable Energy: IntiGIS Model. Case of Study: Zapara Island, Zulia State. Venezuela; Aplicaciones de Sistemas de Informacion Geografica para la Electrificacion Rural con Energias Renovables: Modelo IntiGIS. Caso de Estudio: Isla Zapara, Estado Zulia. Venezuela

    Energy Technology Data Exchange (ETDEWEB)

    Rincon, L; Dominguez, J; Amador, J; Arribas, L; Pinedo, I

    2011-07-01

    This project started as an educational exercise for the Renewable Energy and Environment Master, taught by the Polytechnic University of Madrid, with the purpose of analyze in a real context GIS application in rural electrification with renewable energies. It was developed in collaboration with CIEMAT, ENELVEN (C.A. Energia Electrica de Venezuela), FUNDELEC (Fundacion para el Desarrollo del Servicio Electrico), CORPOLEC (Corporacion Electrica Nacional de Venezuela) and the UPM. The final aim is to define the technology that suits best to Zapara Islands electrification needs. This improvement will make possible the sustainable development of the population. In order to compare electrification technologies to decide which is the most suitable to Zapara Island, using IntiGIS model, will be required a geographic resources analysis, a population distribution and an electricity demand study. Also, it will be necessary to establish the technical parameters of the facility and economic factors that could affect the study. (Author) 14 refs.

  5. Medio ambiente, mercado y Estado

    OpenAIRE

    Duque Escobar, Gonzalo

    2014-01-01

    La fuerza del mercado frente a las falencias del Estado, como factores que explican las barreras para el desarrollo de la vacuna sintética contra la malaria en Colombia y la falta de control a las causas antrópicas del ecosidio de los chigüiros en el desierto de muerte del Casanare

  6. Taquicardias supraventriculares. Estado del arte

    Directory of Open Access Journals (Sweden)

    Jairo Alfonso Gándara Ricardo

    2016-01-01

    El tratamiento de las taquicardias supraventriculares dependerá del estado hemodinámico del paciente, el cual definirá el requerimiento de terapia eléctrica o tratamiento médico. Se debe hacer una selección adecuada de los pacientes que requieren estudio electrofisiológico y ablación.

  7. Morphological responses of the Wax Lake Delta, Louisiana, to Hurricanes Rita

    Directory of Open Access Journals (Sweden)

    Fei Xing

    2017-12-01

    Full Text Available This study examines the morphodynamic response of a deltaic system to extreme weather events. The Wax Lake Delta (WLD in Louisiana, USA, is used to illustrate the impact of extreme events (hurricanes on a river-dominated deltaic system. Simulations using the open source Delft3D model reveal that Hurricane Rita, which made landfall 120 km to the west of WLD as a Category 3 storm in 2005, caused erosion on the right side and deposition on the left side of the hurricane eye track on the continental shelf line (water depth 10 m to 50 m. Erosion over a wide area occurred both on the continental shelf line and in coastal areas when the hurricane moved onshore, while deposition occurred along the Gulf coastline (water depth < 5 m when storm surge water moved back offshore. The numerical model estimated that Hurricane Rita’s storm surge reached 2.5 m, with maximum currents of 2.0 m s–1, and wave heights of 1.4 m on the WLD. The northwestern-directed flow and waves induced shear stresses, caused erosion on the eastern banks of the deltaic islands and deposition in channels located west of these islands. In total, Hurricane Rita eroded more than 500,000 m3 of sediments on the WLD area. Including waves in the analysis resulted in doubling the amount of erosion in the study area, comparing to the wave-excluding scenario. The exclusion of fluvial input caused minor changes in deltaic morphology during the event. Vegetation cover was represented as rigid rods in the model which add extra source terms for drag and turbulence to influence the momentum and turbulence equations. Vegetation slowed down the floodwater propagation and decreased flow velocity on the islands, leading to a 47% reduction in the total amount of erosion. Morphodynamic impact of the hurricane track relative to the delta was explored. Simulations indicate that the original track of Hurricane Rita (landfall 120 km west of the WLD produced twice as much erosion and deposition at the delta

  8. Orkaan Rita ähvardab rüüstata USA naftatööstuse südame / Annika Matson

    Index Scriptorium Estoniae

    Matson, Annika, 1976-

    2005-01-01

    Orkaan Rita läheneb USA naftatööstuse südamele Texasele, kus toodetakse veerand USA naftatoodetest. Diagramm: Naftafirmade aktsiate tõus. Vt. samas: Bensiini hinna olulist tõusu Eestis prognoosida oleks ennatlik

  9. Identification of differentially expressed genes associated with the enhancement of X-ray susceptibility by RITA in a hypopharyngeal squamous cell carcinoma cell line (FaDu

    Directory of Open Access Journals (Sweden)

    Luan Jinwei

    2016-06-01

    Full Text Available Next generation sequencing and bio-informatic analyses were conducted to investigate the mechanism of reactivation of p53 and induction of tumor cell apoptosis (RITA-enhancing X-ray susceptibility in FaDu cells.

  10. RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling.

    Science.gov (United States)

    Zhu, Hong; Abulimiti, Muyasha; Liu, Huan; Su, Xiang-Jiang; Liu, Cai-Hong; Pei, Hai-Ping

    2015-09-01

    Radiation therapy is the most widely used treatment for patients with cervical cancer. Recent studies have shown that endoplasmic reticulum (ER) stress induces apoptosis and sensitizes tumor cells to radiotherapy, which reportedly induces ER stress in cells. Classical key tumor suppressor p53 is involved in the response to a variety of cellular stresses, including those incurred by ionizing irradiation. A recent study demonstrated that small-molecule RITA (reactivation of p53 and induction of tumor cell apoptosis) increased the radiosensitivity of tumor cells expressing mutant p53 (mtp53). In the present study, we explored the effects and the underlying mechanisms of RITA in regards to the radiosensitivity and ER stress in mtp53-expressing human cervix cancer cells. Treatment with 1 µM of RITA for 24 h before irradiation markedly decreased survival and increased apoptosis in C-33A and HT-3 cells; the effects were not significantly altered by knockdown of p53. In the irradiated C-33A and HT-3 cells, RITA significantly increased the expression of IRE1α, the spliced XBP1 mRNA level, as well as apoptosis; the effects were abolished by knockdown of IRE1α. Transcriptional pulse-chase assays revealed that RITA significantly increased the stability of IRE1α mRNA in the irradiated C-33A and HT-3 cells. In contrast, the same RITA treatment did not show any significant effect on sham-irradiated cells. In conclusion, the present study provides initial evidence that RITA upregulates the expression level of IRE1α by increasing the stability of IRE1α mRNA in irradiated mtp53-expressing cervical cancer cells; the effect leads to enhanced IRE1α/XBP1 ER stress signaling and increased apoptosis in the cells. The present study offers novel insight into the pharmacological potential of RITA in the radiotherapy for cervical cancer.

  11. A Prospective Study of Religiousness and Psychological Distress Among Female Survivors of Hurricanes Katrina and Rita

    Science.gov (United States)

    Rhodes, Jean E.; Pérez, John E.

    2013-01-01

    This prospective study examined the pathways by which religious involvement affected the post-disaster psychological functioning of women who survived Hurricanes Katrina and Rita. The participants were 386 low-income, predominantly Black, single mothers. The women were enrolled in the study before the hurricane, providing a rare opportunity to document changes in mental health from before to after the storm, and to assess the protective role of religious involvement over time. Results of structural equation modeling indicated that, controlling for level of exposure to the hurricanes, pre-disaster physical health, age, and number of children, pre-disaster religiousness predicted higher levels of post-disaster (1) social resources and (2) optimism and sense of purpose. The latter, but not the former, was associated with better post-disaster psychological outcome. Mediation analysis confirmed the mediating role of optimism and sense of purpose. PMID:21626083

  12. Satellite Images and Aerial Photographs of the Effects of Hurricanes Katrina and Rita on Coastal Louisiana

    Science.gov (United States)

    Barras, John A.

    2007-01-01

    Introduction Hurricane Katrina made landfall on the eastern coastline of Louisiana on August 29, 2005; Hurricane Rita made landfall on the western coastline of Louisiana on September 24, 2005. Comparison of Landsat Thematic Mapper (TM) satellite imagery acquired before and after the landfalls of Katrina and Rita and classified to identify land and water demonstrated that water area increased by 217 mi2 (562 km2) in coastal Louisiana as a result of the storms. Approximately 82 mi2 (212 km2) of new water areas were in areas primarily impacted by Hurricane Katrina (Mississippi River Delta basin, Breton Sound basin, Pontchartrain basin, and Pearl River basin), whereas 99 mi2 (256 km2) were in areas primarily impacted by Hurricane Rita (Calcasieu/Sabine basin, Mermentau basin, Teche/Vermilion basin, Atchafalaya basin, and Terrebonne basin). Barataria basin contained new water areas caused by both hurricanes, resulting in some 18 mi2 (46.6 km2) of new water areas. The fresh marsh and intermediate marsh communities' land areas decreased by 122 mi2 (316 km2) and 90 mi2 (233.1 km2), respectively, and the brackish marsh and saline marsh communities' land areas decreased by 33 mi2 (85.5 km2) and 28 mi2 (72.5 km2), respectively. These new water areas represent land losses caused by direct removal of wetlands. They also indicate transitory changes in water area caused by remnant flooding, removal of aquatic vegetation, scouring of marsh vegetation, and water-level variation attributed to normal tidal and meteorological variation between satellite images. Permanent losses cannot be estimated until several growing seasons have passed and the transitory impacts of the hurricanes are minimized. The purpose of this study was to provide preliminary information on water area changes in coastal Louisiana acquired shortly after the landfalls of both hurricanes (detectable with Landsat TM imagery) and to serve as a regional baseline for monitoring posthurricane wetland recovery. The land

  13. The monochromatic imaging mode of a RITA-type neutron spectrometer

    International Nuclear Information System (INIS)

    Bahl, C.R.H.; Andersen, P.; Klausen, S.N.; Lefmann, K.

    2004-01-01

    The imaging monochromatic mode of a neutron spectrometer with a multi-bladed RITA analyser system is so far unexplored. We present analytical calculations that define the mode. It is shown that the mode can be realised for PG (0 0 2) analyser crystals, from incident energies of about 3.2 meV and up, allowing the important cases of 3.7, 5.0 and 13.7 meV. Due to beam divergence, the neutron rays from neighbouring analyser blades are found to overlap slightly. Hence, the optimal use of the monochromatic imaging mode would be found by employing an adjustable radial collimator to limit the spread of the ray from each analyser blade

  14. Bacteriological water quality in the Lake Pontchartrain basin Louisiana following Hurricanes Katrina and Rita, September 2005

    Science.gov (United States)

    Stoeckel, Donald M.; Bushon, Rebecca N.; Demcheck, Dennis K.; Skrobialowski, Stanley C.; Kephart, Christopher M.; Bertke, Erin E.; Mailot, Brian E.; Mize, Scott V.; Fendick, Robert B.

    2005-01-01

    The U.S. Geological Survey (USGS), in collaboration with the Louisiana Department of Environmental Quality, monitored bacteriological quality of water at 22 sites in and around Lake Pontchartrain, La., for three consecutive weeks beginning September 13, 2005, following hurricanes Katrina and Rita and the associated flooding. Samples were collected and analyzed by USGS personnel from the USGS Louisiana Water Science Center and the USGS Ohio Water Microbiology Laboratory. Fecal-indicator bacteria (Escherichia coli, enterococci, and fecal coliform) concentrations ranged from the detection limit to 36,000 colony-forming units per 100 milliliters. Data are presented in tabular form and as plots of data in the context of available historical data and water-quality standards and criteria for each site sampled. Quality-control data were reviewed to ensure that methods performed as expected in a mobile laboratory setting.

  15. A prospective study of religiousness and psychological distress among female survivors of Hurricanes Katrina and Rita.

    Science.gov (United States)

    Chan, Christian S; Rhodes, Jean E; Pérez, John E

    2012-03-01

    This prospective study examined the pathways by which religious involvement affected the post-disaster psychological functioning of women who survived Hurricanes Katrina and Rita. The participants were 386 low-income, predominantly Black, single mothers. The women were enrolled in the study before the hurricane, providing a rare opportunity to document changes in mental health from before to after the storm, and to assess the protective role of religious involvement over time. Results of structural equation modeling indicated that, controlling for level of exposure to the hurricanes, pre-disaster physical health, age, and number of children, pre-disaster religiousness predicted higher levels of post-disaster (1) social resources and (2) optimism and sense of purpose. The latter, but not the former, was associated with better post-disaster psychological outcome. Mediation analysis confirmed the mediating role of optimism and sense of purpose.

  16. Rita Temmerman. Towards New Ways of Terminology Description: The Sociocognitive Approach

    Directory of Open Access Journals (Sweden)

    Rosemarie Gläser

    2011-10-01

    Full Text Available This book appeared as Volume 3 in the Series Terminology and Lexicography Research and Practice edited by Helmi Sonneveld and Sue-Ellen Wright. The author, Rita Temmerman, presently working at the Erasmus Hogeschool, Brussels and specialising in problems of terminology in various domains of the life sciences, presents a polemical, stimulating and innovative monograph which continues and deepens her previous research work. Her doctoral dissertation (Louvain 1998 focused on Terminology Beyond Standardisation: Language and Categorisation in the Life Sciences. The aim of the book under review, Towards New Ways of Terminology Description: The Sociocognitive Approach, is to elaborate a new theory, method and application of terminology research which seeks to overcome the obvious limitations of traditional terminology as chiefly represented by the Vienna School (Eugen W?ster, Helmut Felber, Infoterm and associated institutions.

  17. Rezension zu: Rita Pawlowski (Hg.: „Unsere Frauen stehen ihren Mann“. Berlin: trafo Wissenschaftsverlag 2008

    Directory of Open Access Journals (Sweden)

    Susanne Freund

    2009-07-01

    Full Text Available Rita Pawlowski stellt in diesem Band in alphabethischer Ordnung insgesamt 651 Frauen vor, die Abgeordnete der Volkskammer der DDR waren. Nach einer knappen Einführung zur Wahlhäufigkeit weiblicher Abgeordneter, zum Frauenanteil in der Volkskammer und in den Ausschüssen geben die Biographen im Wesentlichen Auskunft über die soziale Herkunft, die Parteizugehörigkeit, die schulische und berufliche Ausbildung und die Berufstätigkeit der einzelnen Frauen. Ziel dieses Bandes ist die Dokumentation des außergewöhnlichen Engagements von Frauen in der DDR, neben Berufstätigkeit und Familienpflichten politische Einflussmöglichkeiten zu nutzen. Damit wird ein Teilaspekt der Lebensgeschichte dieser Frauen beleuchtet, der – wie die Autorin im Vorfeld einräumt – keinen Anspruch auf Vollständigkeit erhebt. Dieser Hinweis ist wichtig, um dieses lexikalische Nachschlagewerk sinnvoll zu handhaben.

  18. The monochromatic imaging mode of a RITA-type neutron spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Bahl, C.R.H. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark) and Department of Physics, Technical University of Denmark, DK-2800 Lyngby (Denmark)]. E-mail: christian.bahl@risoe.dk; Andersen, P. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Niels Bohr Institute for Astronomy, Physics and Geophysics, University of Copenhagen, DK-2100 Copenhagen (Denmark); Klausen, S.N. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Lefmann, K. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark)

    2004-12-01

    The imaging monochromatic mode of a neutron spectrometer with a multi-bladed RITA analyser system is so far unexplored. We present analytical calculations that define the mode. It is shown that the mode can be realised for PG (0 0 2) analyser crystals, from incident energies of about 3.2 meV and up, allowing the important cases of 3.7, 5.0 and 13.7 meV. Due to beam divergence, the neutron rays from neighbouring analyser blades are found to overlap slightly. Hence, the optimal use of the monochromatic imaging mode would be found by employing an adjustable radial collimator to limit the spread of the ray from each analyser blade.

  19. Efficient synthesis of RITA and its analogues: derivation of analogues with improved antiproliferative activity via modulation of p53/miR-34a pathway.

    Science.gov (United States)

    Lin, Jinshun; Jin, Xiuli; Bu, Yiwen; Cao, Deliang; Zhang, Nannan; Li, Shangfu; Sun, Qinsheng; Tan, Chunyan; Gao, Chunmei; Jiang, Yuyang

    2012-12-28

    A novel approach to synthesize RITA by practical palladium-catalyzed C-C bond-forming Suzuki reactions at room temperature was developed, which was used for deriving a series of substituted tricyclic α-heteroaryl (furan/thiophene) analogues of RITA under mild conditions. These novel analogues showed notable antiproliferative activity against cancer cell lines with wild-type p53 (i.e., HCT116, A549, MCF-7 and K562), but much less activity in HCT116/p53(-/-) cells. In particular, compound 1f demonstrated promising antiproliferative activity compared to RITA, with IC(50) = 28 nM in MCF-7 vs. 54 nM for RITA, and cancer cell selectivity. Compound 1f markedly activated p53 in HCT116 cells at 100 nM, triggering apoptosis. Importantly, we found that both RITA and compound 1f induced G(0)/G(1) cell cycle arrest by up-regulating miR-34a, which in turn down-regulated the expression of cell cycle-related proteins CDK4 and E2F1. In summary, this study reports an effective synthetic approach for RITA and its analogues, and elucidates a novel antiproliferative mechanism of these compounds.

  20. Initial management of hospital evacuations caused by Hurricane Rita: a systematic investigation.

    Science.gov (United States)

    Downey, Erin L; Andress, Knox; Schultz, Carl H

    2013-06-01

    Hurricanes remain a major threat to hospitals throughout the world. The authors attempted to identify the planning areas that impact hospital management of evacuations and the challenges faced when sheltering-in-place. This observational, retrospective cohort study examined acute care institutions from one hospital system impacted by Hurricane Rita in 2005. Investigators used a standardized survey instrument and interview process, previously used in the hospital evacuation context, to examine hospitals' initial internal situational awareness and subsequent decision making that resulted in evacuation due to Hurricane Rita. Participants from each hospital included representatives from senior leadership and clinical and nonclinical staff that comprised the Incident Management Team (IMT). The main measured outcomes were responses to 95 questions contained in the survey. Seven of ten eligible hospitals participated in the study. All facilities evacuated the sickest patients first. The most significant factors prompting evacuation were the issuing of mandatory evacuation orders, storm dynamics (category, projected path, storm surge), and loss of regional communications. Hospitals that sheltered-in-place experienced staff shortages, interruptions to electrical power, and loss of water supplies. Three fully-evacuated institutions experienced understaffing of 40%-60%, and four hospitals sustained depressed staffing levels for over four weeks. Five hospitals lost electricity for a mean of 4.8 days (range .5-11 days). All facilities continued to receive patients to their Emergency Departments (EDs) while conducting their own evacuation. Hospital EDs should plan for continuous patient arrival during evacuation. Emergency Operation Plans (EOPs) that anticipate challenges associated with evacuation will help to maximize initial decision making and management during a crisis situation. Hospitals that shelter-in-place face critical shortages and must provide independent patient

  1. Mapping and Visualization of Storm-Surge Dynamics for Hurricane Katrina and Hurricane Rita

    Science.gov (United States)

    Gesch, Dean B.

    2009-01-01

    The damages caused by the storm surges from Hurricane Katrina and Hurricane Rita were significant and occurred over broad areas. Storm-surge maps are among the most useful geospatial datasets for hurricane recovery, impact assessments, and mitigation planning for future storms. Surveyed high-water marks were used to generate a maximum storm-surge surface for Hurricane Katrina extending from eastern Louisiana to Mobile Bay, Alabama. The interpolated surface was intersected with high-resolution lidar elevation data covering the study area to produce a highly detailed digital storm-surge inundation map. The storm-surge dataset and related data are available for display and query in a Web-based viewer application. A unique water-level dataset from a network of portable pressure sensors deployed in the days just prior to Hurricane Rita's landfall captured the hurricane's storm surge. The recorded sensor data provided water-level measurements with a very high temporal resolution at surveyed point locations. The resulting dataset was used to generate a time series of storm-surge surfaces that documents the surge dynamics in a new, spatially explicit way. The temporal information contained in the multiple storm-surge surfaces can be visualized in a number of ways to portray how the surge interacted with and was affected by land surface features. Spatially explicit storm-surge products can be useful for a variety of hurricane impact assessments, especially studies of wetland and land changes where knowledge of the extent and magnitude of storm-surge flooding is critical.

  2. The burden of rare cancers in Italy: the surveillance of rare cancers in Italy (RITA) project.

    Science.gov (United States)

    Trama, Annalisa; Mallone, Sandra; Ferretti, Stefano; Meduri, Francesca; Capocaccia, Riccardo; Gatta, Gemma

    2012-01-01

    The project Surveillance of rare cancers in Italy (RITA) provides, for the first time, estimates of the burden of rare cancers in Italy based on the list of rare cancers proposed in collaboration with the European project Surveillance of Rare Cancers in Europe (RARECARE). RITA analyzed data from Italian population-based cancer registries (CR). The period of diagnosis was 1988 to 2002, and vital status information was available up to December 31, 2003. Incidence rates were estimated for the period 1995-2002, survival for the years 2000-2002 (with the period method of Brenner), and complete prevalence at January 1, 2003. Rare cancers are those with an incidence <6/100,000/year. In Italy, every year there are 60,000 new diagnoses of rare cancers corresponding to 15% of all new cancer diagnoses. Five-year relative survival was on the average worse for rare cancers (53%) than for common cancers (73%). A total of 770,000 patients were living in Italy in 2008 with a diagnosis of a rare cancer, 22% of the total cancer prevalence. Our estimates constitute a useful base for further research and support the idea that rare cancers are a public health problem that deserves attention. Centers of expertise for rare cancers that pool cases, expertise and resources could ensure an adequate clinical management for these diseases. Our data also showed that cancer registries are suitable sources of data to estimate incidence, prevalence and survival for rare cancers and should continue to monitoring rare cancers in Italy.

  3. Rita Pawlowski (Hg.: „Unsere Frauen stehen ihren Mann“. Berlin: trafo Wissenschaftsverlag 2008

    Directory of Open Access Journals (Sweden)

    Susanne Freund

    2009-07-01

    Full Text Available Rita Pawlowski stellt in diesem Band in alphabethischer Ordnung insgesamt 651 Frauen vor, die Abgeordnete der Volkskammer der DDR waren. Nach einer knappen Einführung zur Wahlhäufigkeit weiblicher Abgeordneter, zum Frauenanteil in der Volkskammer und in den Ausschüssen geben die Biographen im Wesentlichen Auskunft über die soziale Herkunft, die Parteizugehörigkeit, die schulische und berufliche Ausbildung und die Berufstätigkeit der einzelnen Frauen. Ziel dieses Bandes ist die Dokumentation des außergewöhnlichen Engagements von Frauen in der DDR, neben Berufstätigkeit und Familienpflichten politische Einflussmöglichkeiten zu nutzen. Damit wird ein Teilaspekt der Lebensgeschichte dieser Frauen beleuchtet, der – wie die Autorin im Vorfeld einräumt – keinen Anspruch auf Vollständigkeit erhebt. Dieser Hinweis ist wichtig, um dieses lexikalische Nachschlagewerk sinnvoll zu handhaben.In this volume, Rita Pawlowski alphabetically introduces a total of 651 women who were representatives of the People’s Chamber of the GDR. Following a short introduction to the election frequency of female representatives and to the number of women in the People’s Chamber and its committees, the biographies provide information on the social origin, party membership, educational and occupational training, and professional life of the individual women. The volume’s goal is to document these women’s extraordinary engagement in the GDR, for they not only held careers and fulfilled family duties, but also pursued possibilities for making political impact. The authors note at the outset that the book does not claim to be comprehensive, for it illuminates merely one aspect of the life stories of these women. This remark is important for making the reference work manageable.

  4. Land area change and fractional water maps in the Chenier Plain, Louisiana, following hurricane Rita

    Science.gov (United States)

    Palaseanu-Lovejoy, M.; Kranenburg, C.; Brock, J. C.

    2009-12-01

    The objective of this study is to develop a fractional water map at 30-m resolution scale using QuickBird and/or IKONOS high-resolution imagery as dependent variable to investigate the impact of hurricane Rita in the Chenier Plain, Louisiana. Eleven different indices were tested to obtain a high-resolution land / water classification on QuickBird (acquired on 05/23/2003) and IKONOS (acquired on 03/25/2006) images. The percent area covered by water in the high resolution images varied from 22 to 26% depending on the index used , with the simple ratio index (red band / NIR band) accounting for the lowest percent and the blue ratio index (blue band / sum(all bands)) for the highest percent. Using the ERDAS NLCD (National Land Cover Data) Mapping tool module, 100, 000 stratified random sample points with minimum 1000 points per stratum were selected from the high resolution dependent variable as training information for the independent variable layers. The rules for the regression tree were created using the data mining software Rulequest Cubist v. 2.05. This information was used to generate a fractional water map for the entire Landsat scene. The increase in water areas of about 10 - 15% between 2003 to 2006, as well as temporary changes in the water - land configurations are attributed to remnant flooding and removal of aquatic vegetation caused by hurricane Rita, and water level variations caused by tidal and / or meteorological variations between the acquisition dates of the satellite images. This analysis can assist in monitoring post-hurricane wetland recovery and assess trends in land loss due to extreme storm events, although estimation of permanent land loss cannot be made until wetland areas have the opportunity to recover from hurricane impacts.

  5. Libertad religiosa y Estado Constitucional

    Directory of Open Access Journals (Sweden)

    Samuel Abad Yupanqui

    2008-12-01

    Full Text Available El presente articulo pretende examinar la evolución del debate constitucional sobre las relaciones Estado–Iglesia en nuestro pais, el actual diseno de estas relaciones a partir de lo dispuesto por el texto constitucional vigente y el Acuerdo suscrito con la Iglesia Catolica en julio de 1980, asi como los alcances de un proyecto de ley que pretende regular la libertad e igualdad religiosas. Asumiendo tal perspectiva recordaremos algunos antecedentes constitucionales que nos muestran por donde se ha encaminado el debate; y examinaremos los principios que orientan la relacion Iglesia-Estado, desde un enfoque de derechos fundamentales y en el marco de la indispensable afirmacion de un Estado Constitucional de Derecho. Ello es particularmente relevante en un pais como el nuestro en donde determinadas concepciones religiosas pretenden establecerse como unico parametro para la adopcion de aquellas politicas publicas respecto a las cuales la Iglesia tiene una posicion definida.

  6. O Centro Espírita Redemptor e o tratamento de doença mental, 1910-1921 The Centro Espírita Redemptor and the treatment of mental illness, 1910-1921

    Directory of Open Access Journals (Sweden)

    André de Faria Pereira Neto

    2012-06-01

    Full Text Available O espiritismo é uma doutrina religiosa que surgiu na França durante o século XIX por meio da obra de Allan Kardec. No Brasil, assumiu certa originalidade: o espiritismo racional e científico cristão, liderado por Luiz de Mattos, foi uma de suas vertentes doutrinárias nacionais. Luiz de Mattos criou o Centro Espírita Redemptor onde, durante alguns anos, acompanhou o tratamento dos doentes mentais. O artigo analisa as características do tratamento espírita racional e científico cristão à doença mental e as estratégias que Luiz de Mattos adotou para defender sua forma de tratamento. Apresenta ainda algumas semelhanças e diferenças entre o tratamento espírita e o médico.Spiritism is a religious doctrine originated in France during the nineteenth century through the works of Allan Kardec. In Brazil, it assumed an original configuration: rational and scientific Christian spiritism, pioneered by Luiz de Mattos, was one of the national doctrinal variants. Luiz de Mattos created the Centro Espírita Redemptor where, for some years, he monitored the treatment of the mentally ill. The article analyzes the characteristics of rational and scientific Christian spiritism treatment applied to mental illness and the strategies that Luiz de Mattos adopted to defend his form of treatment. Some similarities and differences between spiritist and medical treatment are also outlined.

  7. A Kiss Lajos-díj 2016. évi nyertese: dr. Póczos Rita [Winner of the 2016 Lajos Kiss Prize: Dr Rita Póczos

    Directory of Open Access Journals (Sweden)

    Hoffmann, István

    2016-12-01

    Full Text Available The Lajos Kiss Prize, awarded every two or three years since 2006, is considered to be a highly prestigious award for young onomasticians. The 2016 winner of the prize is Dr Rita Póczos, senior lecturer at the Department of Hungarian Linguistics of the University of Debrecen. She was given this award for her contribution to Hungarian Historical Onomastics, especially for her research on place names.

  8. UPANJE IN SVOBODA V DELU STEPHENA KINGA RITA HAYWORTH AND SHAWSHANK REDEMPTION IN ALEXANDRE DUMAS GROF MONTE CRISTO

    OpenAIRE

    Kramar, Vesna

    2011-01-01

    Rita Hayworth and Shawshank Redemption Stephena Kinga in Grof Monte Cristo Alexandra Dumasa izhajata iz različnih literarnih žanrov in se razlikujeta v dogajanju, a imata kljub temu podobno motiviko in tematiko. V obeh zgodbah je nedolžen mož poslan v zapor, iz katerega je pobeg skorajda nemogoč, a se kljub temu obema uspe izmuzniti iz zapora na podoben način

  9. Satellite Assessment of Bio-Optical Properties of Northern Gulf of Mexico Coastal Waters Following Hurricanes Katrina and Rita

    OpenAIRE

    Lohrenz, Steven E.; Cai, Wei-Jun; Chen, Xiaogang; Tuel, Merritt

    2008-01-01

    The impacts of major tropical storms events on coastal waters include sediment resuspension, intense water column mixing, and increased delivery of terrestrial materials into coastal waters. We examined satellite imagery acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS) ocean color sensor aboard the Aqua spacecraft following two major hurricane events: Hurricane Katrina, which made landfall on 29 August 2005, and Hurricane Rita, which made landfall on 24 September. MODIS A...

  10. La serie audiovisual de la colección zuliana: alternativa para la preservación y reconstrucción del patrimonio e identidad del estado Zulia

    Directory of Open Access Journals (Sweden)

    Egla Ortega González

    2006-05-01

    Full Text Available Se analiza la pertinencia del documental como opción para la preservación y divulgación de la identidad zuliana con base a los planteamientos teóricos de Biiri, García Espinosa, Flaherty, Calónico, Getino y Solanas. Igualmente se reflexiona sobre la necesidad de concebir este género cinematográfico de una forma mucho más reflexiva y abierta a las mltiples alternativas de narración, estilo y estructura, más allá de las convenciones mediáticas que lo han limitado y que niegan sus posibilidades dramáticas y estéticas en la reconstrucción y expresión de la cultura y el imaginario. Así mismo, a través de los planteamientos de Urrusti, Altamirano, Morales y Ortega se identifica y reafirma la importancia del testimonio audiovisual en el proceso de desarrollo de colecciones en las organizaciones documentales. Se puntualizan los criterios en el abordaje metodológico de los registros audiovisuales insertados en la Serie Audiovisual de la Colección Zuliana (SACZ. Entre las conclusiones se destaca la relevancia del relato audiovisual en la difusión histórica al preservar en el tiempo los eventos que marcan hito en la construcción y reconstrucción de la sociedad zuliana y se recalca que la circulación de los documentales generados en la SACZ reforzarán el diálogo intercultural, la comprensión y el conocimiento recíproco entre culturas latinoamericanas.

  11. Las cooperativas como estrategia de gestión para el fomento de la economía social en el municipio Maracaibo del estado Zulia. Período: 1999-2006

    OpenAIRE

    Graterol, Angela; Alizo, María Alexandra; Molero, Norma

    2010-01-01

    La presente investigación tuvo como objetivo analizar las cooperativas como estrategias de gestión para el fomento de la economía social. Se enmarca en el paradigma positivista, de carácter descriptiva analítica y el diseño es no experimental- transeccional. La muestra estuvo conformada por dos mil doscientos cuarenta y dos socios de cooperativas del municipio Maracaibo, registradas en la superintendencia nacional de cooperativas (SUNACOOP). Se utilizaron fuentes primarias y secundarias para ...

  12. Spatial-temporal water quality parameters evaluation of the Santa Rita river (BA with respect to the release of manipueira

    Directory of Open Access Journals (Sweden)

    Franklin Delano Porto Júnior

    2012-12-01

    Full Text Available The watershed of the river Santa Rita includes the towns of Simão and Campinhos, where exists about 150 flour houses. Campinhos is among the largest cassava processing facilities in the region, generating many direct and indirect jobs. Manipueira is a liquid residue originating from the cassava pressing and presents high pollutant potential due to its high amount of glucose and fructose, this potential is 25 times greater than the one from domestic sewer. This work had as objective the evaluation of possible impacts of manipueira release in the water quality of Santa Rita river. For this, the land use map was elaborated and the physiographic characterization developed, besides being performed six campaigns for water samples collection in four sampling points along the river. The obtained results indicated that the watershed is elongated, with low drainage efficiency and it is not prone to flooding. Estimated water quality parameters indicated that organic effluents from Campinhos and Simão impact the values of dissolved oxygen, electrical conductivity, salinity, ammonia, nitrite, nitrate and zinc, suggesting that the water quality of the river Santa Rita is affected by manipueira release. The concentrations of total phosphorus, iron and cooper were superior downstream of the Sewer Treatment Station. The river water was saline in the three sampling points most affected by the release of manipueira.

  13. Identification of differentially expressed genes associated with the enhancement of X-ray susceptibility by RITA in a hypopharyngeal squamous cell carcinoma cell line (FaDu).

    Science.gov (United States)

    Luan, Jinwei; Li, Xianglan; Guo, Rutao; Liu, Shanshan; Luo, Hongyu; You, Qingshan

    2016-06-01

    Next generation sequencing and bio-informatic analyses were conducted to investigate the mechanism of reactivation of p53 and induction of tumor cell apoptosis (RITA)-enhancing X-ray susceptibility in FaDu cells. The cDNA was isolated from FaDu cells treated with 0 X-ray, 8 Gy X-ray, or 8 Gy X-ray + RITA. Then, cDNA libraries were created and sequenced using next generation sequencing, and each assay was repeated twice. Subsequently, differentially expressed genes (DEGs) were identified using Cuffdiff in Cufflinks and their functions were predicted by pathway enrichment analyses. Genes that were constantly up- or down-regulated in 8 Gy X-ray-treated FaDu cells and 8 Gy X-ray + RITA-treated FaDu cells were obtained as RITA genes. Afterward, the protein-protein interaction (PPI) relationships were obtained from the STRING database and a PPI network was constructed using Cytoscape. Furthermore, ClueGO was used for pathway enrichment analysis of genes in the PPI network. Total 2,040 and 297 DEGs were identified in FaDu cells treated with 8 Gy X-ray or 8 Gy X-ray + RITA, respectively. PARP3 and NEIL1 were enriched in base excision repair, and CDK1 was enriched in p53 signaling pathway. RFC2 and EZH2 were identified as RITA genes. In the PPI network, many interaction relationships were identified (e.g., RFC2-CDK1, EZH2-CDK1 and PARP3-EZH2). ClueGO analysis showed that RFC2 and EZH2 were related to cell cycle. RFC2, EZH2, CDK1, PARP3 and NEIL1 may be associated, and together enhance the susceptibility of FaDu cells treated with RITA to the deleterious effects of X-ray.

  14. Identification of differentially expressed genes associated with the enhancement of X-ray susceptibility by RITA in a hypopharyngeal squamous cell carcinoma cell line (FaDu)

    International Nuclear Information System (INIS)

    Luan, Jinwei; Li, Xianglan; Guo, Rutao; Liu, Shanshan; Luo, Hongyu; You, Qingshan

    2016-01-01

    Next generation sequencing and bio-informatic analyses were conducted to investigate the mechanism of reactivation of p53 and induction of tumor cell apoptosis (RITA)-enhancing X-ray susceptibility in FaDu cells. The cDNA was isolated from FaDu cells treated with 0 X-ray, 8 Gy X-ray, or 8 Gy X-ray + RITA. Then, cDNA libraries were created and sequenced using next generation sequencing, and each assay was repeated twice. Subsequently, differentially expressed genes (DEGs) were identified using Cuffdiff in Cufflinks and their functions were predicted by pathway enrichment analyses. Genes that were constantly up- or down-regulated in 8 Gy X-ray-treated FaDu cells and 8 Gy X-ray + RITA-treated FaDu cells were obtained as RITA genes. Afterward, the protein-protein interaction (PPI) relationships were obtained from the STRING database and a PPI network was constructed using Cytoscape. Furthermore, ClueGO was used for pathway enrichment analysis of genes in the PPI network. Total 2,040 and 297 DEGs were identified in FaDu cells treated with 8 Gy X-ray or 8 Gy X-ray + RITA, respectively. PARP3 and NEIL1 were enriched in base excision repair, and CDK1 was enriched in p53 signaling pathway. RFC2 and EZH2 were identified as RITA genes. In the PPI network, many interaction relationships were identified (e.g., RFC2-CDK1, EZH2-CDK1 and PARP3-EZH2). ClueGO analysis showed that RFC2 and EZH2 were related to cell cycle. RFC2, EZH2, CDK1, PARP3 and NEIL1 may be associated, and together enhance the susceptibility of FaDu cells treated with RITA to the deleterious effects of X-ray

  15. Use of Temporary Immersion System (RITA in sugarcane the plants propagation by organogenesis

    Directory of Open Access Journals (Sweden)

    Laisyn Posada-Pérez

    2003-01-01

    Full Text Available The present work had as objective to study the possibilities to use the RITA, in the micropropagation plant via axillary buds of sugarcane and of the banana hybrid (Musa sp. AAAA cv. FHIA-01 and AAAB cv. FHIA-18. Two different culture medium i.e. multiplication and thickenment were studied in the multiplication phase of two varieties of sugarcane. It was also studied the number of initial explants to use (two, four and six, using as control flasks with explants liquid and semisolid medium. The number of immersions in 24 hours was analysed and also the time for culture media change was determined testing two periods, 15 days and 30 days respectively. Similar variables were studied for the case of the banana cultivar except for the medium culture. It was obtained like half of more appropriate cultivation for sugarcane that of multiplication with two explants, in the two used varieties, not presenting significant differences the times of change of half made to the 15 and 30 days. For the case of the banana cultivar employment of five explantes for FHIA-01 and three or five explantes for FHIA-18 to begin the multiplication allowed to reach the best results. Regarding the number of immersions it presented bigger superiority the treatment of three immersions during 24 hours, for both banana cultivars. Keys words: liquid medium, micropropagation, Musa, Saccharum

  16. Hazardous substances releases associated with Hurricanes Katrina and Rita in industrial settings, Louisiana and Texas.

    Science.gov (United States)

    Ruckart, Perri Zeitz; Orr, Maureen F; Lanier, Kenneth; Koehler, Allison

    2008-11-15

    The scientific literature concerning the public health response to the unprecedented hurricanes striking the Gulf Coast in August and September 2005 has focused mainly on assessing health-related needs and surveillance of injuries, infectious diseases, and other illnesses. However, the hurricanes also resulted in unintended hazardous substances releases in the affected states. Data from two states (Louisiana and Texas) participating in the Hazardous Substances Emergency Events Surveillance (HSEES) system were analyzed to describe the characteristics of hazardous substances releases in industrial settings associated with Hurricanes Katrina and Rita. HSEES is an active multi-state Web-based surveillance system maintained by the Agency for Toxic Substances and Disease Registry (ATSDR). In 2005, 166 hurricane-related hazardous substances events in industrial settings in Louisiana and Texas were reported. Most (72.3%) releases were due to emergency shut downs in preparation for the hurricanes and start-ups after the hurricanes. Emphasis is given to the contributing causal factors, hazardous substances released, and event scenarios. Recommendations are made to prevent or minimize acute releases of hazardous substances during future hurricanes, including installing backup power generation, securing equipment and piping to withstand high winds, establishing procedures to shutdown process operations safely, following established and up-to-date start-up procedures and checklists, and carefully performing pre-start-up safety reviews.

  17. Changes in microbial community structure in the wake of Hurricanes Katrina and Rita.

    Science.gov (United States)

    Amaral-Zettler, Linda A; Rocca, Jennifer D; Lamontagne, Michael G; Dennett, Mark R; Gast, Rebecca J

    2008-12-15

    Hurricanes have the potential to alter the structures of coastal ecosystems and generate pathogen-laden floodwaters thatthreaten public health. To examine the impact of hurricanes on urban systems, we compared microbial community structures in samples collected after Hurricane Katrina and before and after Hurricane Rita. We extracted environmental DNA and sequenced small-subunit rRNA (SSU rRNA) gene clone libraries to survey microbial communities in floodwater, water, and sediment samples collected from Lake Charles, Lake Pontchartrain, the 17th Street and Industrial Canals in New Orleans, and raw sewage. Correspondence analysis showed that microbial communities associated with sediments formed one cluster while communities associated with lake and Industrial Canal water formed a second. Communities associated with water from the 17th Street Canal and floodwaters collected in New Orleans showed similarity to communities in raw sewage and contained a number of sequences associated with possible pathogenic microbes. This suggests that a distinct microbial community developed in floodwaters following Hurricane Katrina and that microbial community structures as a whole might be sensitive indicators of ecosystem health and serve as "sentinels" of water quality in the environment.

  18. Promoting mental health recovery after hurricanes Katrina and Rita: what can be done at what cost.

    Science.gov (United States)

    Schoenbaum, Michael; Butler, Brittany; Kataoka, Sheryl; Norquist, Grayson; Springgate, Benjamin; Sullivan, Greer; Duan, Naihua; Kessler, Ronald C; Wells, Kenneth

    2009-08-01

    Concerns about mental health recovery persist after the 2005 Gulf storms. We propose a recovery model and estimate costs and outcomes. To estimate the costs and outcomes of enhanced mental health response to large-scale disasters using the 2005 Gulf storms as a case study. Decision analysis using state-transition Markov models for 6-month periods from 7 to 30 months after disasters. Simulated movements between health states were based on probabilities drawn from the clinical literature and expert input. A total of 117 counties/parishes across Louisiana, Mississippi, Alabama, and Texas that the Federal Emergency Management Agency designated as eligible for individual relief following hurricanes Katrina and Rita. Hypothetical cohort, based on the size and characteristics of the population affected by the Gulf storms. Intervention Enhanced mental health care consisting of evidence-based screening, assessment, treatment, and care coordination. Morbidity in 6-month episodes of mild/moderate or severe mental health problems through 30 months after the disasters; units of service (eg, office visits, prescriptions, hospital nights); intervention costs; and use of human resources. Full implementation would cost $1133 per capita, or more than $12.5 billion for the affected population, and yield 94.8% to 96.1% recovered by 30 months, but exceed available provider capacity. Partial implementation would lower costs and recovery proportionately. Evidence-based mental health response is feasible, but requires targeted resources, increased provider capacity, and advanced planning.

  19. Somatic experiencing treatment with social service workers following Hurricanes Katrina and Rita.

    Science.gov (United States)

    Leitch, M Laurie; Vanslyke, Jan; Allen, Marisa

    2009-01-01

    In a disaster, social service workers are often survivors themselves.This study examines whether somatic intervention using a brief (one to two session) stabilization model now called the Trauma Resiliency Model (TRM), which uses the skills of Somatic Experiencing (SE), can reduce the postdisaster symptoms of social service workers involved in postdisaster service delivery.The study was implemented with a nonrandom sample of 142 social service workers who were survivors of Hurricanes Katrina and Rita in New Orleans and Baton Rouge, Louisiana, two to three months after the disasters. Ninety-one participants received SE/TRM and were compared with a matched comparison group of 51 participants through the use of propensity score matching. All participants first received group psychoeducation. Results support the benefits of the brief intervention inspired by SE. The treatment group showed statistically significant gains in resiliency indicators and decreases in posttraumatic stress disorder symptoms. Although psychological symptoms increased in both groups at the three to four month follow-up, the treatment group's psychological symptoms were statistically lower than those of the comparison group.

  20. Lead distributions and risks in New Orleans following Hurricanes Katrina and Rita.

    Science.gov (United States)

    Abel, Michael T; Cobb, George P; Presley, Steven M; Ray, Gary L; Rainwater, Thomas R; Austin, Galen P; Cox, Stephen B; Anderson, Todd A; Leftwich, Blair D; Kendall, Ronald J; Suedel, Burton C

    2010-07-01

    During the last four years, significant effort has been devoted to understanding the effects that Hurricanes Katrina and Rita had on contaminant distribution and redistribution in New Orleans, Louisiana, USA, and the surrounding Gulf Coast area. Elevated concentrations were found for inorganic contaminants (including As, Fe, Pb, and V), several organic pollutants (polycyclic aromatic hydrocarbons, pesticides, and volatiles) and high concentration of bioaerosols, particularly Aeromonas and Vibrio. Data from different research groups confirm that some contaminant concentrations are elevated, that existing concentrations are similar to historical data, and that contaminants such as Pb and As may pose human health risks. Two data sets have been compiled in this article to serve as the foundation for preliminary risk assessments within greater New Orleans. Research from the present study suggests that children in highly contaminated areas of New Orleans may experience Pb exposure from soil ranging from 1.37 microg/d to 102 microg/d. These data are critical in the evaluation of children's health. Copyright (c) 2010 SETAC.

  1. The effects of hurricane Rita and subsequent drought on alligators in southwest Louisiana.

    Science.gov (United States)

    Lance, Valentine A; Elsey, Ruth M; Butterstein, George; Trosclair, Phillip L; Merchant, Mark

    2010-02-01

    Hurricane Rita struck the coast of southwest Louisiana in September 2005. The storm generated an enormous tidal surge of approximately four meters in height that inundated many thousands of acres of the coastal marsh with full strength seawater. The initial surge resulted in the deaths of a number of alligators and severely stressed those who survived. In addition, a prolonged drought (the lowest rainfall in 111 years of recorded weather data) following the hurricane resulted in highly saline conditions that persisted in the marsh for several months. We had the opportunity to collect 11 blood samples from alligators located on Holly Beach less than a month after the hurricane, but were unable to collect samples from alligators on Rockefeller Wildlife Refuge until February 2006. Conditions at Rockefeller Refuge did not permit systematic sampling, but a total of 201 samples were collected on the refuge up through August 2006. The blood samples were analyzed for sodium, potassium, chloride, osmolality, and corticosterone. Blood samples from alligators sampled on Holly Beach in October 2005, showed a marked elevation in plasma osmolality, sodium, chloride, potassium, corticosterone, and an elevated heterophil/lymphocyte ratio. Blood samples from alligators on Rockefeller Refuge showed increasing levels of corticosterone as the drought persisted and elevated osmolality and electrolytes. After substantial rainfall in July and August, these indices of osmotic stress returned to within normal limits. (c) 2009 Wiley-Liss, Inc.

  2. Ethnobotanical study of medicinal plants in the community of Santa Rita, Ituiutaba – Minas Gerais, Brazil

    Directory of Open Access Journals (Sweden)

    Glaucieli Siqueira Parreira Alves

    2013-09-01

    Full Text Available This paper aimed to inventory the plants used in popular medicine by members of the rural community of Santa Rita, in the town of Ituiutaba, Minas Gerais, Brazil. The evaluation was carried out through interviews, with a semi-structured questionnaire and subsequent collection of the plants indicated by informants. One conducted 47 interviews and 127 species were listed, belonging to 55 Angiosperm families. For obtaining the quantitative data, one calculated the percentage of the Main Use Concordance (cMUC of each species; for identifying the therapeutic indications with greater importance, one used the Informant Consensus Factor (ICF. The cMUC showed that 5.5% of the plants mentioned are widely used by the community. The predominant botanical families registered were Lamiaceae and Asteraceae, with 14 and 13 records, respectively. The indication of predominant use mainly involved illnesses related to an emotional disorder, as indicated by the ICF. One emphasizes that 60.7% of the plants mentioned in this paper are exotic species; thus, there’s a need for further studies in order to catalogue knowledge on the medicinal plants which are native to this region.

  3. The Multiple Life of Nerve Growth Factor: Tribute to Rita Levi-Montalcini (1909-2012

    Directory of Open Access Journals (Sweden)

    Luigi Aloe

    2013-03-01

    Full Text Available At the end of the 19th century, it was envisaged by Santiago Ramon y Cajal, but not, proven, that life at the neuronal level requires trophic support. The proof was obtained in the early 1950's by work initiated by Rita Levi-Montalcini (RLM discovering the nerve growth factor (NGF. Today, NGF and its relatives, collectively designated neurotrophins, are well recognized as mediators of multiple biological phenomena in health and disease, ranging from the neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. Consequently, NGF and other neurotrophins are implicated in the pathogenesis of a large spectrum of neuronal and non-neuronal diseases, from Alzheimer's and other neurodegenerative diseases to atherosclerosis and other cardiometabolic diseases. Recent studies demonstrated the therapeutic potentials of NGF in these diseases, including ocular and cutaneous diseases. Furthermore, NGF TrkA receptor antagonists emerged as novel drugs for pain, prostate and breast cancer, melanoma, and urinary bladder syndromes. Altogether, NGF's multiple potential in health and disease is briefly described here.

  4. Recovery Migration after Hurricanes Katrina and Rita: Spatial Concentration and Intensification in the Migration System

    Science.gov (United States)

    Fussell, Elizabeth; DeWaard, Jack

    2015-01-01

    Changes in the human migration systems of Hurricane Katrina- and Rita-affected Gulf of Mexico coastline counties provide an example of how climate change may affect coastal populations. Crude climate change models predict a mass migration of “climate refugees,” but an emerging literature on environmental migration suggests most migration will be short-distance and short-duration within existing migration systems, with implications for the population recovery of disaster-struck places. In this research, we derive a series of hypotheses on recovery migration predicting how the migration system of hurricane-affected coastline counties in the Gulf of Mexico was likely to have changed between the pre-disaster and the recovery periods. We test these hypotheses using data from the Internal Revenue Service on annual county-level migration flows, comparing the recovery period migration system (2007–2009) to the pre-disaster period (1999–2004). By observing county-to-county ties and flows we find that recovery migration was strong, as the migration system of the disaster-affected coastline counties became more spatially concentrated while flows within it intensified and became more urbanized. Our analysis demonstrates how migration systems are likely to be affected by the more intense and frequent storms anticipated by climate change scenarios with implications for the population recovery of disaster-affected places. PMID:26084982

  5. Recovery Migration After Hurricanes Katrina and Rita: Spatial Concentration and Intensification in the Migration System.

    Science.gov (United States)

    Curtis, Katherine J; Fussell, Elizabeth; DeWaard, Jack

    2015-08-01

    Changes in the human migration systems of the Gulf of Mexico coastline counties affected by Hurricanes Katrina and Rita provide an example of how climate change may affect coastal populations. Crude climate change models predict a mass migration of "climate refugees," but an emerging literature on environmental migration suggests that most migration will be short-distance and short-duration within existing migration systems, with implications for the population recovery of disaster-stricken places. In this research, we derive a series of hypotheses on recovery migration predicting how the migration system of hurricane-affected coastline counties in the Gulf of Mexico was likely to have changed between the pre-disaster and the recovery periods. We test these hypotheses using data from the Internal Revenue Service on annual county-level migration flows, comparing the recovery period migration system (2007-2009) with the pre-disaster period (1999-2004). By observing county-to-county ties and flows, we find that recovery migration was strong: the migration system of the disaster-affected coastline counties became more spatially concentrated, while flows within it intensified and became more urbanized. Our analysis demonstrates how migration systems are likely to be affected by the more intense and frequent storms anticipated by climate change scenarios, with implications for the population recovery of disaster-affected places.

  6. Hazardous substances releases associated with Hurricanes Katrina and Rita in industrial settings, Louisiana and Texas

    International Nuclear Information System (INIS)

    Ruckart, Perri Zeitz; Orr, Maureen F.; Lanier, Kenneth; Koehler, Allison

    2008-01-01

    The scientific literature concerning the public health response to the unprecedented hurricanes striking the Gulf Coast in August and September 2005 has focused mainly on assessing health-related needs and surveillance of injuries, infectious diseases, and other illnesses. However, the hurricanes also resulted in unintended hazardous substances releases in the affected states. Data from two states (Louisiana and Texas) participating in the Hazardous Substances Emergency Events Surveillance (HSEES) system were analyzed to describe the characteristics of hazardous substances releases in industrial settings associated with Hurricanes Katrina and Rita. HSEES is an active multi-state Web-based surveillance system maintained by the Agency for Toxic Substances and Disease Registry (ATSDR). In 2005, 166 hurricane-related hazardous substances events in industrial settings in Louisiana and Texas were reported. Most (72.3%) releases were due to emergency shut downs in preparation for the hurricanes and start-ups after the hurricanes. Emphasis is given to the contributing causal factors, hazardous substances released, and event scenarios. Recommendations are made to prevent or minimize acute releases of hazardous substances during future hurricanes, including installing backup power generation, securing equipment and piping to withstand high winds, establishing procedures to shutdown process operations safely, following established and up-to-date start-up procedures and checklists, and carefully performing pre-start-up safety reviews

  7. Nephrologic Impact of Hurricanes Katrina and Rita in Areas Not Directly Affected.

    Science.gov (United States)

    Dossabhoy, Neville R; Qadri, Mashood; Beal, Lauren M

    2015-01-01

    Hurricanes Katrina and Rita resulted in enormous loss of life and disrupted the delivery of health care in areas affected by them. In causing mass movements of patients, natural disasters can overwhelm the resources of nephrology communities in areas not suffering direct damage. The following largely personal account evaluates the impact these hurricanes had upon the nephrology community, patients and health care providers alike, in areas not directly affected by the storms. Mass evacuation of hundreds of dialysis patients to surrounding areas overwhelmed the capacity of local hemodialysis centers. Non-availability of medical records in patients arriving without a supply of their routine medications led to confusion and sub-optimal treatment of conditions such as hypertension and congestive heart failure. Availability of cadaveric organs for transplantation was reduced in the surrounding areas, as the usual lines of communication and transportation were severed for several weeks. All of these issues led to prolong waiting times for patients on the transplant list. The hurricanes severely disrupted usual supply lines of medications to hospitals; certain rare conditions may be seen in higher numbers as a result of the shortages induced. We present the interesting surge in cases of acute kidney injury secondary to use of intravenous immune globulin.

  8. Tres cartas para la traición de Rita Hayworth

    Directory of Open Access Journals (Sweden)

    José Amícola

    1996-11-01

    Full Text Available El artículo trata la relación entre los manuscritos previos a la escritura de la primera novela de Manuel Puig y la novela terminada [de 1968]. El capítulo inserto cerca del final de la novela [en forma de'carta anónima'] habla asimismo de la voluntad de conformar una estructura armónica, donde surja un movimiento bipolar de ritmo distendido versus otro agitado, a la vez que obliga a la participación del lector en la tarea de la identidad del presunto remitente del anónimo. La segunda carta analizada [el último capítulo de la novela] nos lleva al centro de una crítica genética en la que se evidencia el trabajo de pulimiento del broche final, como clave de todo el texto. La tercera carta analizada aquí [borrador de carta del escritor a la actriz Rita Hayworth, de 1966], es un paratexto [es decir: un texto no ficcional independiente]. El borrador de esa carta a la actriz que da nombre a la obra sirve al geneticista como piedra de toque para descubrir la intención autorial con respecto al núcleo argumental de la novela, un núcleo que los esquemas pre-textuales anunciaban como 'la verdad'

  9. Os Episódios de Rita Patrício

    Directory of Open Access Journals (Sweden)

    Gustavo Rubim

    2014-12-01

    O texto propõe uma leitura do livro Episódios: da teorização estética em Fernando Pessoa, da au­toria de Rita Patrício. Datado de 2012, o livro só ficou realmente pronto e publicado em 2014. A leitura de­fende a originalidade deste exame minucioso dos textos de teoria estética e literária de Fernando Pessoa, tanto pela maneira como os trata autonomamente da obra poética e os estuda na sua escrita específica, quanto pelo efeito de deslocação dos tópicos habituais na análise do programa modernista português. A crí­tica do idealismo pessoano e da noção de obra enquanto totalidade or­gânica são sublinhados enquanto gestos condutores de toda a pesquisa. Propõem-se articulações com outros ensaios recentes que em Portugal procedem à revisão da crítica e da hermenêutica pes­soana.

  10. In vitro propagation of Phalaenopsis (Orchidaceae from protocorms, using the temporary inmersion system "RITA"

    Directory of Open Access Journals (Sweden)

    Jorge Mario Tirado

    2005-01-01

    Full Text Available In order to massively propagate Phalaenopsis orchids, three months old in vitro protocorms were transferred to RITA® vessels. The evaluation factors were the sucrose concentration in the culture medium and the frequency immersion. There was a set of five pairs of RITA® vessels with liquid culture medium containing sucrose at 0,15, 30, 45, 60 g/L. A half-strength MS medium plus vitamins, supplemented with vitamins and thidiazuron (5 mg/L was used. The experiment had two stages, each lasting two months. Each stage had a one minute immersion. The first stage had a four hour immersion frequency and the second one had an eight hour immersion frequency. Results showed that the best proliferating response was reached in a 15 g/L of sucrose medium with one minute of immersion time every four hours, resulting in 8,2 adventitious protocorms per protocorm per month. Key words: Phalaenopsis, protocorm, in vitro propagation, temporary immersion, RITA.

  11. A Green Prison: Santa Rita Jail Creeps Towards Zero Net Energy (ZNE)

    Energy Technology Data Exchange (ETDEWEB)

    Marnay, Chris; DeForest, Nicholas; Stadler, Michael; Donadee, Jon; Dierckxsens, Carlos; Mendes, Goncalo; Lai, Judy; Cardoso, Goncalo Ferreira

    2011-03-18

    A large project is underway at Alameda County's twenty-year old 45 ha 4,000-inmate Santa Rita Jail, about 70 km east of San Francisco. Often described as a green prison, it has a considerable installed base of distributed energy resources including a seven-year old 1.2 MW PV array, a four-year old 1 MW fuel cell with heat recovery, and efficiency investments. A current US$14 M expansion will add approximately 2 MW of NaS batteries, and undetermined wind capacity and a concentrating solar thermal system. This ongoing effort by a progressive local government with considerable Federal and State support provides some excellent lessons for the struggle to lower building carbon footprint. The Distributed Energy Resources Customer Adoption Model (DER-CAM) finds true optimal combinations of equipment and operating schedules for microgrids that minimize energy bills and/or carbon emissions without 2 of 12 significant searching or rules-of-thumb prioritization, such as"efficiency first then on-site generation." The results often recommend complex systems, and sensitivities show how policy changes will affect choices. This paper reports an analysis of the historic performance of the PV system and fuel cell, describes the complex optimization applied to the battery scheduling, and shows how results will affect the jail's operational costs, energy consumption, and carbon footprint. DER-CAM is used to assess the existing and proposed DER equipment in its ability to reduce tariff charges.

  12. Hazardous substances releases associated with Hurricanes Katrina and Rita in industrial settings, Louisiana and Texas

    Energy Technology Data Exchange (ETDEWEB)

    Ruckart, Perri Zeitz [Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA (United States)], E-mail: afp4@cdc.gov; Orr, Maureen F. [Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA (United States); Lanier, Kenneth; Koehler, Allison [Louisiana Department of Health and Hospitals, Office of Public Health, New Orleans, LA (United States)

    2008-11-15

    The scientific literature concerning the public health response to the unprecedented hurricanes striking the Gulf Coast in August and September 2005 has focused mainly on assessing health-related needs and surveillance of injuries, infectious diseases, and other illnesses. However, the hurricanes also resulted in unintended hazardous substances releases in the affected states. Data from two states (Louisiana and Texas) participating in the Hazardous Substances Emergency Events Surveillance (HSEES) system were analyzed to describe the characteristics of hazardous substances releases in industrial settings associated with Hurricanes Katrina and Rita. HSEES is an active multi-state Web-based surveillance system maintained by the Agency for Toxic Substances and Disease Registry (ATSDR). In 2005, 166 hurricane-related hazardous substances events in industrial settings in Louisiana and Texas were reported. Most (72.3%) releases were due to emergency shut downs in preparation for the hurricanes and start-ups after the hurricanes. Emphasis is given to the contributing causal factors, hazardous substances released, and event scenarios. Recommendations are made to prevent or minimize acute releases of hazardous substances during future hurricanes, including installing backup power generation, securing equipment and piping to withstand high winds, establishing procedures to shutdown process operations safely, following established and up-to-date start-up procedures and checklists, and carefully performing pre-start-up safety reviews.

  13. The multiple life of nerve growth factor: tribute to rita levi-montalcini (1909-2012).

    Science.gov (United States)

    Aloe, Luigi; Chaldakov, George N

    2013-03-01

    At the end of the 19(th) century, it was envisaged by Santiago Ramon y Cajal, but not, proven, that life at the neuronal level requires trophic support. The proof was obtained in the early 1950's by work initiated by Rita Levi-Montalcini (RLM) discovering the nerve growth factor (NGF). Today, NGF and its relatives, collectively designated neurotrophins, are well recognized as mediators of multiple biological phenomena in health and disease, ranging from the neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. Consequently, NGF and other neurotrophins are implicated in the pathogenesis of a large spectrum of neuronal and non-neuronal diseases, from Alzheimer's and other neurodegenerative diseases to atherosclerosis and other cardiometabolic diseases. Recent studies demonstrated the therapeutic potentials of NGF in these diseases, including ocular and cutaneous diseases. Furthermore, NGF TrkA receptor antagonists emerged as novel drugs for pain, prostate and breast cancer, melanoma, and urinary bladder syndromes. Altogether, NGF's multiple potential in health and disease is briefly described here.

  14. Homage to Rita Levi-Montalcini, the queen of modern neuroscience.

    Science.gov (United States)

    Aloe, Luigi; Chaldakov, George N

    2013-08-01

    The first cell growth factor, nerve growth factor (NGF), was discovered by Rita Levi-Montalcini (RLM) in the early 1950s. Originally identified as neurite outgrowth-stimulating factor, later studies revealed that non-neuronal cells, including immune cells, endothelial cells, cardiomyocytes, pancreatic beta cells, prostate epithelial and adipose tissue cells, were also targets for and/or sources of NGF. Nerve growth factor is well recognised as mediating multiple biological phenomena, ranging from the neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. Consequently, NGF and other members of the neurotrophin family are implicated in the pathogenesis of a large spectrum of neuronal and non-neuronal diseases, ranging from Alzheimer's and other neurodegenerative diseases to atherosclerosis and cardiometabolic disorders. Recent studies have demonstrated the therapeutic potentials of NGF in these conditions, including ocular and cutaneous diseases. NGF TrkA receptor antagonists emerged as novel drugs for pain, prostate and breast cancer, melanoma and urinary bladder syndromes. Here, we briefly describe the 'unpredictable' ideogenesis of the discovery of NGF, a eureka in the neuroscience. © 2013 International Federation for Cell Biology.

  15. Impacts of Hurricanes Katrina and Rita on the microbial landscape of the New Orleans area.

    Science.gov (United States)

    Sinigalliano, C D; Gidley, M L; Shibata, T; Whitman, D; Dixon, T H; Laws, E; Hou, A; Bachoon, D; Brand, L; Amaral-Zettler, L; Gast, R J; Steward, G F; Nigro, O D; Fujioka, R; Betancourt, W Q; Vithanage, G; Mathews, J; Fleming, L E; Solo-Gabriele, H M

    2007-05-22

    Floodwaters in New Orleans from Hurricanes Katrina and Rita were observed to contain high levels of fecal indicator bacteria and microbial pathogens, generating concern about long-term impacts of these floodwaters on the sediment and water quality of the New Orleans area and Lake Pontchartrain. We show here that fecal indicator microbe concentrations in offshore waters from Lake Pontchartrain returned to prehurricane concentrations within 2 months of the flooding induced by these hurricanes. Vibrio and Legionella species within the lake were more abundant in samples collected shortly after the floodwaters had receded compared with samples taken within the subsequent 3 months; no evidence of a long-term hurricane-induced algal bloom was observed. Giardia and Cryptosporidium were detected in canal waters. Elevated levels of fecal indicator bacteria observed in sediment could not be solely attributed to impacts from floodwaters, as both flooded and nonflooded areas exhibited elevated levels of fecal indicator bacteria. Evidence from measurements of Bifidobacterium and bacterial diversity analysis suggest that the fecal indicator bacteria observed in the sediment were from human fecal sources. Epidemiologic studies are highly recommended to evaluate the human health effects of the sediments deposited by the floodwaters.

  16. Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation.

    Science.gov (United States)

    Ma, Teng; Yamada, Shumpei; Ichwan, Solachuddin J A; Iseki, Sachiko; Ohtani, Kiyoshi; Otsu, Megumi; Ikeda, Masa-Aki

    2012-01-20

    The p53 tumor suppressor protein plays key roles in protecting cells from tumorigenesis. Phosphorylation of p53 at Ser46 (p53Ser46) is considered to be a crucial modification regulating p53-mediated apoptosis. Because the activity of p53 is impaired in most human cancers, restoration of wild-type p53 (wt-p53) function by its gene transfer or by p53-reactivating small molecules has been extensively investigated. The p53-reactivating compounds Nutlin-3 and RITA activate p53 in the absence of genotoxic stress by antagonizing the action of its negative regulator Mdm2. Although controversial, Nutlin-3 was shown to induce p53-mediated apoptosis in a manner independent of p53 phosphorylation. Recently, RITA was shown to induce apoptosis by promoting p53Ser46 phosphorylation. Here we examined whether Nutlin-3 or RITA can overcome resistance to p53-mediated apoptosis in p53-resistant tumor cell lines lacking the ability to phosphorylate p53Ser46. We show that Nutlin-3 did not rescue the apoptotic defect of a Ser46 phosphorylation-defective p53 mutant in p53-sensitive tumor cells, and that RITA neither restored p53Ser46 phosphorylation nor induced apoptosis in p53Ser46 phosphorylation-deficient cells retaining wt-p53. Furthermore, treatment with Nutlin-3 or RITA together with adenoviral p53 gene transfer also failed to induce apoptosis in p53Ser46 phosphorylation-deficient cells either expressing or lacking wt-p53. These results indicate that neither Nutlin-3 nor RITA in able to induce p53-mediated apoptosis in the absence of p53Ser46 phosphorylation. Thus, the dysregulation of this phosphorylation in tumor cells may be a critical factor that limits the efficacy of these p53-based cancer therapies. Copyright © 2011 Elsevier Inc. All rights reserved.

  17. RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53abnormal myeloma cells independently of the p53 pathway.

    Science.gov (United States)

    Surget, Sylvanie; Descamps, Géraldine; Brosseau, Carole; Normant, Vincent; Maïga, Sophie; Gomez-Bougie, Patricia; Gouy-Colin, Nadège; Godon, Catherine; Béné, Marie C; Moreau, Philippe; Le Gouill, Steven; Amiot, Martine; Pellat-Deceunynck, Catherine

    2014-06-14

    The aim of this study was to evaluate the efficacy of the p53-reactivating drugs RITA and nutlin3a in killing myeloma cells. A large cohort of myeloma cell lines (n = 32) and primary cells (n = 21) was used for this study. This cohort contained cell lines with various TP53 statuses and primary cells with various incidences of deletion of chromosome 17. Apoptosis was evaluated using flow cytometry with Apo2.7 staining of the cell lines or via the loss of the myeloma-specific marker CD138 in primary cells. Apoptosis was further confirmed by the appearance of a subG1 peak and the activation of caspases 3 and 9. Activation of the p53 pathway was monitored using immunoblotting via the expression of the p53 target genes p21, Noxa, Bax and DR5. The involvement of p53 was further studied in 4 different p53-silenced cell lines. Both drugs induced the apoptosis of myeloma cells. The apoptosis that was induced by RITA was not related to the TP53 status of the cell lines or the del17p status of the primary samples (p = 0.52 and p = 0.80, respectively), and RITA did not commonly increase the expression level of p53 or p53 targets (Noxa, p21, Bax or DR5) in sensitive cells. Moreover, silencing of p53 in two TP53(mutated) cell lines failed to inhibit apoptosis that was induced by RITA, which confirmed that RITA-induced apoptosis in myeloma cells was p53 independent. In contrast, apoptosis induced by nutlin3a was directly linked to the TP53 status of the cell lines and primary samples (p RITA, in contrast to nutlin3a, effectively induced apoptosis in a subset of MM cells independently of p53. The findings and could be of interest for patients with a 17p deletion, who are resistant to current therapies.

  18. Mineral, Energy, and Fertilizer Resources of the North Coast of Peru: Perspective from the Santa Rita B Archaeological Site

    Science.gov (United States)

    Brooks, William E.; Kent, Jonathan D.; Willett, Jason C.

    2004-01-01

    The Santa Rita B archaeological site is in the Chao Valley, approximately 65 km southeast of Trujillo, northern Peru. Location of Santa Rita B at the emergence of several drainages from the Andean cordillera is an important factor in the almost continuous occupation of the site over the past 3,000 years. Mineral resources are abundant throughout the Andes; however, the north coast of Peru was an important center for pre-Columbian mining, metallurgy, and craftsmanship. Success of the Chavin, Moche, Chimu, and other north coast cultures is directly related to the availability and exploitation of mineral and energy resources that include: gold (?silver), as electrum, mainly from placers, and copper from local oxide and carbonate occurrences and from sulfides related to copper porphyry occurrences in the cordillera. An alloy of these three metals is referred to as tumbaga, which is the primary material for Andean metalcraft. Anthracite was used for mirrors by north coast cultures and is available near Rio Chicama, Rio Santa, and east of Santa Rita B. These outcrops are a part of the Alto Chicama, Peru's largest coalfield, which extends from Rio Chicama, in the north, for 200 km southward to Rio Santa. Charcoal from the algorrobo tree and llama dung are considered to be the common pre-Columbian energy sources for cooking and metalwork; however, availability and the higher heat content of anthracite indicate that it was used in metallurgical applications. Bitumen is available from petroleum seeps near Talara, north of the study area, and may have been used as glue or as cement. Hematite, goethite, limonite, and manganese oxides from clay-altered volcanic rock may have provided color and material for ceramics. Guano from the Islas Gua?apes, Chinchas, and Ballestas was used as fertilizer for cotton and other crops.

  19. After Hurricanes Katrina and Rita: gender differences in health and religiosity in middle-aged and older adults.

    Science.gov (United States)

    Brown, Jennifer Silva; Cherry, Katie E; Marks, Loren D; Jackson, Erin M; Volaufova, Julia; Lefante, Christina; Jazwinski, S Michal

    2010-11-01

    We examined health-related quality of life in adults in the Louisiana Health Aging Study (LHAS) after Hurricanes Katrina and Rita (HK/R) that made landfall on the U.S. Gulf Coast region in 2005. Analyses of pre- and post-disaster SF-36 scores yielded changes in physical function and bodily pain. Mental health scores were lower for women than men. Gender differences were observed in religious beliefs and religious coping, favoring women. Religious beliefs and religious coping were negatively correlated with physical function, implying that stronger reliance on religiosity as a coping mechanism may be more likely among those who are less physically capable.

  20. CREACIÓN DE UN METAVERSO EN OPENSIM PARA LA UNIVERSIDAD DISTRITAL DENTRO DE LA RED RITA-UD

    Directory of Open Access Journals (Sweden)

    Nicolás Torres Vallejo

    2013-01-01

    Full Text Available Este paper contempla el montaje de un segmento de red inalámbrico para la red RITA-UD con el fin de brindar acceso a contenidos multimedia a través de un mundo virtual creado en OPENSIM. Los contenidos de las emisiones de streaming se encuentran almacenados en un servidor ubicado en el centro de computación de alto desempeño, CECAD. Al tiempo  que se realizaron pruebas de streaming multicast, se capturaron dichas transmisiones mediante el sniffer de paquetes WireShark con el fin de determinar parámetros de QoS que caractericen el canal.

  1. Geomorphic and ecological effects of Hurricanes Katrina and Rita on coastal Louisiana marsh communities

    Science.gov (United States)

    Piazza, Sarai C.; Steyer, Gregory D.; Cretini, Kari F.; Sasser, Charles E.; Visser, Jenneke M.; Holm, Guerry O.; Sharp, Leigh A.; Evers, D. Elaine; Meriwether, John R.

    2011-01-01

    Hurricanes Katrina and Rita made landfall in 2005, subjecting the coastal marsh communities of Louisiana to various degrees of exposure. We collected data after the storms at 30 sites within fresh (12), brackish/intermediate (12), and saline (6) marshes to document the effects of saltwater storm surge and sedimentation on marsh community dynamics. The 30 sites were comprised of 15 pairs. Most pairs contained one site where data collection occurred historically (that is, prestorms) and one Coastwide Reference Monitoring System site. Data were collected from spring 2006 to fall 2007 on vegetative species composition, percentage of vegetation cover, aboveground and belowground biomass, and canopy reflectance, along with discrete porewater salinity, hourly surface-water salinity, and water level. Where available, historical data acquired before Hurricanes Katrina and Rita were used to compare conditions and changes in ecological trajectories before and after the hurricanes. Sites experiencing direct and indirect hurricane influences (referred to in this report as levels of influence) were also identified, and the effects of hurricane influence were tested on vegetation and porewater data. Within fresh marshes, porewater salinity was greater in directly impacted areas, and this heightened salinity was reflected in decreased aboveground and belowground biomass and increased cover of disturbance species in the directly impacted sites. At the brackish/intermediate marsh sites, vegetation variables and porewater salinity were similar in directly and indirectly impacted areas, but porewater salinity was higher than expected throughout the study. Interestingly, directly impacted saline marsh sites had lower porewater salinity than indirectly impacted sites, but aboveground biomass was greater at the directly impacted sites. Because of the variable and site-specific nature of hurricane influences, we present case studies to help define postdisturbance baseline conditions in

  2. Estudo etnobotânico de plantas medicinais na comunidade de Santa Rita, Ituiutaba – MG

    Directory of Open Access Journals (Sweden)

    Juliana Aparecida Povh

    2013-07-01

    Full Text Available http://dx.doi.org/10.5007/2175-7925.2013v26n3p231 O objetivo deste artigo foi inventariar as plantas utilizadas na medicina popular pelos membros da comunidade rural de Santa Rita, no município de Ituiutaba - MG. A avaliação foi realizada por meio de entrevistas, com um questionário semiestruturado, e posterior coleta das plantas indicadas pelos informantes. Foram realizadas 47 entrevistas e 127 espécies foram listadas, pertencentes a 55 famílias de Angiospermas. Para obtenção dos dados quantitativos foi calculada a porcentagem de Concordância de Usos Principais (CUP de cada espécie; para identificar as indicações terapêuticas de maior importância, utilizou-se o Fator de Consenso dos Informantes (FCI. A CUP demonstrou que 5,5% das plantas citadas são amplamente utilizadas pela comunidade. As famílias botânicas predominantes foram Lamiaceae e Asteraceae, com 14 e 13 registros, respectivamente. A indicação de uso predominante envolveu, principalmente, afecções relacionadas a distúrbio emocional, conforme indicado pelo FCI. Salienta-se que 60,7% das plantas citadas neste artigo são espécies exóticas; desse modo, se faz necessário mais estudos para catalogar o conhecimento sobre as plantas medicinais nativas dessa região.

  3. Hurricane Rita surge data, southwestern Louisiana and southeastern Texas, September to November 2005

    Science.gov (United States)

    McGee, Benton D.; Goree, Burl B.; Tollett, Roland W.; Woodward, Brenda K.; Kress, Wade H.

    2006-01-01

    Pressure transducers and high-water marks were used to document the inland water levels related to storm surge generated by Hurricane Rita in southwestern Louisiana and southeastern Texas. On September 22-23, 2005, an experimental monitoring network consisting of 47 pressure transducers (sensors) was deployed at 33 sites over an area of about 4,000 square miles to record the timing, extent, and magnitude of inland hurricane storm surge and coastal flooding. Sensors were programmed to record date and time, temperature, and barometric or water pressure. Water pressure was corrected for changes in barometric pressure and salinity. Elevation surveys using global-positioning systems and differential levels were used to relate all storm-surge water-level data, reference marks, benchmarks, sensor measuring points, and high-water marks to the North American Vertical Datum of 1988 (NAVD 88). The resulting data indicated that storm-surge water levels over 14 feet above NAVD 88 occurred at three locations and rates of water-level rise greater than 5 feet per hour occurred at three locations near the Louisiana coast. Quality-assurance measures were used to assess the variability and accuracy of the water-level data recorded by the sensors. Water-level data from sensors were similar to data from co-located sensors, permanent U.S. Geological Survey streamgages, and water-surface elevations performed by field staff. Water-level data from sensors at selected locations were compared to corresponding high-water mark elevations. In general, the water-level data from sensors were similar to elevations of high quality high-water marks, while reporting consistently higher than elevations of lesser quality high-water marks.

  4. Post disaster resilience: Racially different correlates of depression symptoms among hurricane Katrina-Rita volunteers.

    Science.gov (United States)

    Nicdao, Ethel G; Noel, La Tonya; Ai, Amy L; Plummer, Carol; Groff, Sara

    2013-01-01

    The present analyses examined the differential risks of and protective factors against depressive symptoms of African American and Non-Hispanic White American student volunteers, respectively after Hurricanes Katrina and Rita (H-KR). A total sample of 554 student volunteers were recruited from mental health professional programs at five universities located in the Deep South, namely areas severely impacted by H-KR during fall semester 2005. The response rate was 91% (n = 505). African American respondents (n = 299) and Non-Hispanic White Americans (n = 206) completed the survey questionnaires. Respondents retrospectively provided information on peritraumatic emotional reactions and previous trauma that were recalled by H-KR and H-KR stressors. African American respondents reported higher levels of depressive symptoms (65.2%) than their Non-Hispanic White counterparts (34.8%). Hierarchical regression analyses revealed that disaster related stressors affected African Americans (p < 0.001), but not Non-Hispanic Whites. However, African Americans who experienced peritraumatic positive emotions had lower depression levels. Lower rates of recollection of prior traumas during H-KR were reported by African American respondents, whereas previous trauma recollections predicted symptoms among Non-Hispanic White Americans (p < 0.05). Exhibiting more optimism had lower depression levels among Non-Hispanic White Americans. Peritraumatic negative emotion was the only shared risk for depressive symptoms of both groups. Findings underscore racially different levels of depressive symptoms that may contribute to varying degrees of resilience among student volunteers. Future research and practice may address these racial differences by understanding the risk factors for depressive symptoms to develop appropriate interventions for racial groups, and cultivating the protective factors that contribute to resilience from traumatic experiences.

  5. Effects of hurricanes Katrina and Rita on Louisiana black bear habitat

    Science.gov (United States)

    Clark, Joseph D.; Murrow, Jennifer L.

    2012-01-01

    The Louisiana black bear (Ursus americanus luteolus) is comprised of 3 subpopulations, each being small, geographically isolated, and vulnerable to extinction. Hurricanes Katrina and Rita struck the Louisiana and Mississippi coasts in 2005, potentially altering habitat occupied by this federally threatened subspecies. We used data collected on radio-telemetered bears from 1993 to 1995 and pre-hurricane landscape data to develop a habitat model based on the Mahalanobis distance (D2) statistic. We then applied that model to post-hurricane landscape data where the telemetry data were collected (i.e., occupied study area) and where bear range expansion might occur (i.e., unoccupied study area) to quantify habitat loss or gain. The D2 model indicated that quality bear habitat was associated with areas of high mast-producing forest density, low water body density, and moderate forest patchiness. Cross-validation and testing on an independent data set in central Louisiana indicated that prediction and transferability of the model were good. Suitable bear habitat decreased from 348 to 345 km2 (0.9%) within the occupied study area and decreased from 34,383 to 33,891 km2 (1.4%) in the unoccupied study area following the hurricanes. Our analysis indicated that bear habitat was not significantly degraded by the hurricanes, although changes that could have occurred on a microhabitat level would be more difficult to detect at the resolution we used. We suggest that managers continue to monitor the possible long-term effects of these hurricanes (e.g., vegetation changes from flooding, introduction of toxic chemicals, or water quality changes).

  6. Assessing the Relationship Between Mental Distress and Tobacco Use in Post-Katrina and Rita Louisiana.

    Science.gov (United States)

    Mukherjee, Snigdha; Canterberry, Melanie; Yore, Jennifer B; Ledford, Edward Cannon; Carton, Thomas W

    2017-08-24

    The relationship between mental health status and smoking is complicated and often confounded by bi-directionality, yet most research on this relationship assumes exogeneity. The goal of this article is to implement an instrumental variable approach to (1) test the exogeneity assumption and (2) report on the association between mental health status and smoking post-disaster. This analysis utilizes the 2006 and 2007 Louisiana Behavioral Risk Factor Surveillance Survey to examine the link between mental distress and smoking in areas affected by Hurricanes Katrina and Rita. Residence in a hurricane-affected parish (county) was used as an instrumental variable for mental distress. Just over 22% of the sample resided in a hurricane-affected parish. Residents of hurricane-affected parishes were significantly more likely to report occasional and frequent mental distress. Residence in a hurricane-affected parish was not significantly associated with smoking status. With residence established as a salient instrumental variable for mental distress, the exogeneity assumption was tested and confirmed in this sample. A dose-response relationship existed between mental distress and smoking, with smoking prevalence increasing directly (and non-linearly) with mental distress. In this sample, the relationship between mental distress and smoking status was exogenous and followed a dose-response relationship, suggesting that the disasters did not result in an uptake of smoking initiation, but that the higher amounts of mental distress may lead to increased use among smokers. The findings suggest that tobacco control programs should devise unique strategies to address mentally distressed populations.

  7. Kinematic structure of convective-scale elements in the rainbands of Hurricanes Katrina and Rita (2005)

    Science.gov (United States)

    Hence, Deanna A.; Houze, Robert A.

    2008-08-01

    Airborne Doppler radar data collected during the Hurricane Rainband and Intensity Change Experiment (RAINEX) show the convective-scale air motions embedded in the principal rainbands of hurricanes Katrina and Rita. These embedded convective cells have overturning updrafts and low-level downdrafts (originating at 2-4 km) that enter the rainband on its radially outward side and cross over each other within the rainband as well as a strong downdraft emanating from upper levels (6+ km) on the radially inward side. These vertical motion structures repeat from one convective cell to another along each rainband. The resulting net vertical mass transport is upward in the upwind portion of the band and greatest in the middle sector of the principal rainband, where the updraft motions contribute generally to an increase of potential vorticity below the 3-4 km level. Because the convective cells in the middle sector are systematically located radially just inside the secondary horizontal wind maximum (SHWM), the local increase in vorticity implied by the convective mass transport is manifest locally as an increase in the strength of the SHWM at midlevels (˜4 km). The overturning updrafts of the convective cells tilt, stretch, and vertically transport vorticity such that the convergence of the vertical flux of vorticity strengthens the vorticity anomaly associated with the SHWM. This process could strengthen the SHWM by several meters per second per hour, and may explain how high wave number convective-scale features can influence a low wave number feature such as the principal rainband, and subsequently influence the primary vortex.

  8. El estado Schumpeteriano en diálogo con el estado de bienestar

    OpenAIRE

    Peñas Felizzola, Olga Luz

    2010-01-01

    El presente trabajo se desarrolla con la intención de dar cuenta de algunos de los planteamientos básicos de la teoría del estado Schumpeteriano, particularmente alrededor de dos reflexiones centrales: la importancia de la obra de Schumpeter para la teoría económica, y los elementos distintivos entre el estado Shumpeteriano y el estado de Bienestar.

  9. Calidad de gestión en las unidades de información de la Universidad del Zulia: paradigma de innovación en la sociedad del conocimiento

    Directory of Open Access Journals (Sweden)

    Norcka Fernández

    2008-05-01

    Full Text Available Idealmente se le ha llamado sociedad de la información y del conocimiento aquella con pleno acceso y capacidad de utilización de la información para el desarrollo individual y colectivo de los ciudadanos. Desde el siglo XIX las unidades de información (UI han trabajado a favor del acceso público del conocimiento con base en lo teórico y lo práctico de ahí que en su historia se encuentren aportaciones y respuestas concretas a retos informativos y sociales, sobre todo en momentos tan cruciales cuando el uso de la información-conocimiento que demanda la sociedad actual, ha pasado a ser un insumo indispensable para su desarrollo, lo que ha conllevado a las UI a incorporar paulatinamente el concepto de calidad. Sin embargo la filosofía que preside la obtención de calidad, no se basa en la premisa de la simple mejora de los productos y servicios ofrecidos en las mismas, sino en la adecuación de éstos a las necesidades del usuario. A tal efecto el propósito de esta investigación fue determinar el grado de aplicación de la técnica gerencial calidad total (CT en la gestión de las unidades de información (bibliotecas y archivos de la Universidad del Zulia con la finalidad de indagar la problemática gerencial que puedan presentar estos servicios. Para ello se realizó una investigación documental basada en la revisión bibliográfica de contenidos de orden teórico en los cuales se reflejan las posiciones coincidentes y contradictorias de los enfoques o tendencias analizadas, así como en el estudio de los planes estratégicos de los sistemas de información de la Universidad del Zulia (SAILUZ y SERBILUZ Los resultados evidenciaron que la CT es aplicada en las UI y que es utilizada en un promedio alto a nivel teórico, sin embargo, se encontraron debilidades en su rendimiento. Se concluye que la utilización de la CT orienta el proceso de toma de decisiones, ayuda a la integración y cooperación de los individuos y fomenta el trabajo

  10. Hurricane Rita and the destruction of Holly Beach, Louisiana: Why the chenier plain is vulnerable to storms

    Science.gov (United States)

    Sallenger, A.H.; Wright, C.W.; Doran, K.; Guy, K.; Morgan, K.

    2009-01-01

    Hurricane Rita devastated gulf-front communities along the western Louisiana coast in 2005. LIDAR (light detection and ranging) topographic surveys and aerial photography collected before and after the storm showed the loss of every structure within the community of Holly Beach. Average shoreline change along western Louisiana's 140-km-long impacted shore was -23.3 ?? 30.1 m of erosion, although shoreline change in Holly Beach was substantially less, and erosion was not pervasive where the structures were lost. Before the storm, peak elevations of the dunes, or berms in the absence of dunes, along the impacted shore averaged 1.6 m. The storm surge, which reached 3.5 m just east of Holly Beach, completely inundated the beach systems along the impacted western Louisiana shore. The high surge potential and low land elevations make this coast extremely vulnerable to hurricanes. In fact, most of the western Louisiana shore impacted by Rita will be completely inundated by the storm surge of a worst-case Saffi r-Simpson category 1 hurricane. All of this shore will be inundated by worst-case category 2-5 storms. ?? 2009 The Geological Society of America.

  11. Nonlinear terms in storm surge predictions: Effect of tide and shelf geometry with case study from Hurricane Rita

    Science.gov (United States)

    Rego, JoãO. L.; Li, Chunyan

    2010-06-01

    This study applied the finite volume coastal ocean model (FVCOM) to the storm surge induced by Hurricane Rita along the Louisiana-Texas coast. The model was calibrated for tides and validated with observed water levels. Peak water levels were shown to be lower than expected for a landfall at high tide. For low- and high-tide landfalls, nonlinear effects due to tide-surge coupling were constructive and destructive to total storm tide, respectively, and their magnitude reached up to 70% of the tidal amplitude in the Rita application. Tide-surge interaction was further examined using a standard hurricane under idealized scenarios to evaluate the effects of various shelf geometries, tides, and landfall timings (relative to tide). Nonlinearity was important between landfall position and locations within 2.5 × radius of maximum winds. On an idealized wide continental shelf, nonlinear effects reached up to 80% of the tidal amplitude with an S2 tide and up to 47% with a K1 tide. Increasing average depths by 4 m reduced nonlinear effects to 41% of the tidal amplitude; increasing the slope by a factor of 3 produced nonlinearities of just 26% of tide (both with a K1 tide). The nonlinear effect was greatest for landfalls at low tide, followed by landfalls at high tide and then by landfalls at midebb or midflood.

  12. Mammals of medium and large size in Santa Rita do Sapucaí, Minas Gerais, southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Eduardo, A. A.

    2009-01-01

    Full Text Available The diversity of Brazilian vertebrates is regarded among the highest in the world. However, the biologicaldiversity is still mostly unknown and a good part of it is seriously threatened by human activities. This study aimed toinventory the medium and large size mammals present in the Reserva Biológica de Santa Rita do Sapucaí, an Atlanticforest reserve located in Santa Rita do Sapucaí, southeastern Brazil. Sand-plots, photographic traps and searches foranimal tracks on pre-existent trails in the area, were carried out once every two months between May 2006 andFebruary 2007. The sand-plots and tracks were inspected during five consecutive days per sampling. We obtained 108records of 15 species, mostly of carnivorans. Two confirmed species are threatened with extinction in Brazil (Callithrixaurita and Leopardus pardalis. The results suggest that the sampled reserve has high species richness and plays animportant role in conservation of mammals in this landscape, including species threatened with extinction.

  13. hoteleras del Estado Nueva Esparta

    Directory of Open Access Journals (Sweden)

    Daisis Giménez Sifontes

    2015-01-01

    Full Text Available Las empresas hoteleras deben contar con modelos de costos para obtener información relevante en el proceso de toma de decisiones gerenciales; sin embargo, a través de estudio previo, aplicando un análisis univariante se determinó que las empresas hoteleras categorizadas del Estado Nueva Esparta se basan en un modelo inorgánico de costos. En este contexto, la presente investigación tuvo como objetivo determinar los factores que influyen en ese modelo para su proceso de toma de decisiones, para ello se realizó un diseño de campo y aplicó un análisis factorial exploratorio con el método de extracción de factores análisis de componentes principales concluyendo que entre los factores que lo explican se encuentran, el no manejar herramientas como: margen de contribución, costos estándares, margen de seguridad, apalancamiento operativo, contabilidad por área de responsabilidad, aspectos motivacionales y congruencias de metas.

  14. El Estado laico y Occidente

    Directory of Open Access Journals (Sweden)

    Roberto Blancarte Pimentel

    2016-01-01

    Full Text Available ¿A qué se refieren por Occidente sus detractores? ¿Cómo lo concebimos nosotros mismos? ¿Cuáles son sus valores e instituciones centrales? ¿Cómo entendemos la expansión de esos valores e instituciones y su relación con otras culturas? ¿Son la secularización y la laicidad de las instituciones políticas un elemento central y específico de nuestra cultura? ¿Son parte integrante de lo que algunos grupos consideran la agresión de Occidente hacia sus sociedades? ¿Es compatible la secularización de la sociedad y la laicización de las instituciones políticas, del Estado o de la esfera pública, con otras culturas? Más allá de las implicaciones en materia de violencia o, eventualmente, de estrategia militar, es evidente que las respuestas que se den a estos interrogantes tienen múltiples consecuencias sobre la estabilidad social, la seguridad, las migraciones, las libertades, las concepciones de vida y sobre todo, sobre las formas de convivencia social. Entonces tenemos que detenernos para saber quiénes somos ante nosotros mismos y los demás. En este artículo se presenta una posible respuesta a estos interrogantes.

  15. Santa Rita Experimental Range: 100 years (1903 to 2003) of accomplishments and contributions; conference proceedings; 2003 October 30-November 1; Tucson, AZ

    Science.gov (United States)

    Mitchel P. McClaran; Peter F. Ffolliott; Carleton B. Edminster

    2003-01-01

    The purpose of this conference was to celebrate the 100 years of accomplishments and contributions of the Santa Rita Experimental Range, the longest continuously operating research area dedicated to the sustainable management of North American rangelands. The conference consisted of one-and-a-half days of invited synthesis papers and contributed poster presentations...

  16. Impacts of Hurricane Rita on the beaches of western Louisiana: Chapter 5D in Science and the storms-the USGS response to the hurricanes of 2005

    Science.gov (United States)

    Stockdon, Hilary F.; Fauver, Laura A.; Sallenger,, Asbury H.; Wright, C. Wayne

    2007-01-01

    Hurricane Rita made landfall as a category 3 storm in western Louisiana in late September 2005, 1 month following Hurricane Katrina's devastating landfall in the eastern part of the State. Large waves and storm surge inundated the lowelevation coastline, destroying many communities and causing extensive coastal change including beach, dune, and marsh erosion.

  17. Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents

    NARCIS (Netherlands)

    Michaelis, M.; Rothweiler, F.; Agha, B.; Barth, S.; Voges, Y.; Loeschmann, N.; von Deimling, A.; Breitling, R.; Doerr, H. Wilhelm; Roedel, F.; Speidel, D.; Cinatl, J.; Cinatl Jr., J.; Stephanou, A.

    Adaptation of wild-type p53 expressing UKF-NB-3 cancer cells to the murine double minute 2 inhibitor nutlin-3 causes de novo p53 mutations at high frequency (13/20) and multi-drug resistance. Here, we show that the same cells respond very differently when adapted to RITA, a drug that, like nutlin-3,

  18. Hurricanes Katrina and Rita: Temporary Emergency Impact Aid Provided Education Support for Displaced Students. Report to the Congressional Requesters. GAO-11-839

    Science.gov (United States)

    Scott, George A.

    2011-01-01

    In August and September 2005, Hurricanes Katrina and Rita devastated large portions of the U.S. Gulf Coast, resulting in nearly 2,000 deaths and severe damage to 305,000 houses and apartments. Thousands of families relocated to communities throughout the United States and enrolled their children in local public or private schools. Some families…

  19. The Walnut Gulch - Santa Rita Wildland Watershed-Scale LTAR Sites

    Science.gov (United States)

    Goodrich, D. C.; Heilman, P.; Scott, R. L.; Nearing, M. A.; Moran, M. S.; Nichols, M.; Vivoni, E. R.; Archer, S. R.; Biederman, J.; Naito, A. T.

    2015-12-01

    The 150 km2 Walnut Gulch Experimental Watershed (WGEW), a Long-Term Agroecosystem Research (LTAR) site, near Tombstone, Arizona was established in 1953 by the USDA-ARS Southwest Watershed Research Center in Tucson. It is one of the most intensively instrumented semiarid experimental watersheds in the world with elevation ranging from 1220 to 1950 m with mean annual temperature and precipitation equal to 17.7°C and 312 mm. Desert shrubs dominate the lower two thirds of the watershed and grasses the upper third. Spatial variation in precipitation is measured with a network of 88 weighing-type recording rain gauges. Surface runoff is quantified over a range of scales (0.002 to 0.06 km2) to characterize interactions between rainfall intensity, soils and vegetation at nine sub-watersheds. Channel network processes and rainfall spatial variability are studied using 11 nested watersheds (2 to 150 km2). Sediment from the small sub-watersheds is sampled. Meteorological, soil moisture and temperature, and energy/water/CO2 flux measurements are made within two vegetation/soil complexes. Parallel investigations dating back to 1974 have also been conducted on eight small experimental watersheds at the Santa Rita Experimental Range (SRER) 80 km west of Walnut Gulch. In contrast to the creosote bush-grass WGEW, the mesquite-grass SRER is publicly owned, which ensures control and consistent reporting of management for research purposes. A key LTAR objective is to contrast a "business as usual" to an alternate management strategy presumed to have the potential of significantly improving forage and livestock production and diversification of ecosystem services. Consequently, a new ARS-U. of Arizona-Arizona State U. partnership will assess the watershed-scale impacts of brush management, a common land use practice typically applied in conjunction with livestock grazing, on a suite of ecosystem services at the SRER including provisioning (forage production, water yield), supporting

  20. Regeneration of coastal marsh vegetation impacted by hurricanes Katrina and Rita

    Science.gov (United States)

    Middleton, B.A.

    2009-01-01

    The dynamics of plant regeneration via seed and vegetative spread in coastal wetlands dictate the nature of community reassembly that takes place after hurricanes or sea level rise. The objectives of my project were to evaluate the potential effects of saltwater intrusion and flooding of Hurricanes Katrina and Rita on seedling regeneration in coastal wetlands of the Gulf Coast. Specifically I tested hypotheses to determine for species in fresh, brackish and salt marshes of the Gulf Coast if 1) the pattern of seed germination and seedling recruitment differed with distance from the shoreline, and 2) seed germination and seedling recruitment for various species were reduced in higher levels of water depth and salinity. Regarding Hypothesis 1, seedling densities increased with distance from the shoreline in fresh and brackish water marshes while decreasing with distance from the shoreline in salt marshes. Also to test Hypothesis 1, I used a greenhouse seed bank assay to examine seed germination from seed banks collected at distances from the shoreline in response to various water depths and salinity levels using a nested factorial design. For all marsh types, the influence of water level and salinity on seed germination shifted with distance from the shoreline (i.e., three way interaction of the main effects of distance nested within site, water depth, and salinity). Data from the seed bank assay were also used to test Hypothesis 2. The regeneration of species from fresh, brackish, and salt marshes were reduced in conditions of high salinity and/or water, so that following hurricanes or sea level rise, seedling regeneration could be reduced. Among the species of these coastal marshes, there was some flexibility of response, so that at least some species were able to germinate in either high or low salinity. Salt marshes had a few fresher marsh species in the seed bank that would not germinate without a period of fresh water input (e.g., Sagittaria lancifolia) as well

  1. EAARL coastal topography and imagery–Western Louisiana, post-Hurricane Rita, 2005: First surface

    Science.gov (United States)

    Bonisteel-Cormier, Jamie M.; Wright, Wayne C.; Fredericks, Alexandra M.; Klipp, Emily S.; Nagle, Doug B.; Sallenger, Asbury H.; Brock, John C.

    2013-01-01

    These remotely sensed, geographically referenced color-infrared (CIR) imagery and elevation measurements of lidar-derived first-surface (FS) topography datasets were produced by the U.S. Geological Survey (USGS), St. Petersburg Coastal and Marine Science Center, St. Petersburg, Florida, and the National Aeronautics and Space Administration (NASA), Wallops Flight Facility, Virginia. This project provides highly detailed and accurate datasets of a portion of the Louisiana coastline beachface, acquired post-Hurricane Rita on September 27-28 and October 2, 2005. The datasets are made available for use as a management tool to research scientists and natural-resource managers. An innovative airborne lidar instrument originally developed at the National Aeronautics and Space Administration (NASA) Wallops Flight Facility, and known as the Experimental Advanced Airborne Research Lidar (EAARL), was used during data acquisition. The EAARL system is a raster-scanning, waveform-resolving, green-wavelength (532-nanometer) lidar designed to map near-shore bathymetry, topography, and vegetation structure simultaneously. The EAARL sensor suite includes the raster-scanning, water-penetrating full-waveform adaptive lidar, a down-looking red-green-blue (RGB) digital camera, a high-resolution multispectral color-infrared (CIR) camera, two precision dual-frequency kinematic carrier-phase GPS receivers, and an integrated miniature digital inertial measurement unit, which provide for sub-meter georeferencing of each laser sample. The nominal EAARL platform is a twin-engine Cessna 310 aircraft, but the instrument may be deployed on a range of light aircraft. A single pilot, a lidar operator, and a data analyst constitute the crew for most survey operations. This sensor has the potential to make significant contributions in measuring sub-aerial and submarine coastal topography within cross-environmental surveys. Elevation measurements were collected over the survey area using the EAARL

  2. Competencias en I+D del personal que labora en los Centros de Investigación adscritos a la Escuela de Educación de la Universidad del Zulia

    Directory of Open Access Journals (Sweden)

    Maritza Torres

    2005-05-01

    Full Text Available Se estudian las competencias en I+D de investigadores de los Centros de Investigación de la Escuela de Educación de l Universidad del Zulia. Es una investigación descriptiva, transversal y de campo. La muestra fue de 36 unidades muestrales, con validación de 5 expertos y confiabilidad de Kuder-Richarson. Se encontró que existe un porcentaje bajo de doctorados, hay planeación tecnológica, organización para la innovación, la gestión tecnológica está dirigida a la adquisición de conocimientos, la evaluación es ex –post y on-going. Se da más importancia a las competencias relacionadas con el desempeño docente y menos a las relacionadas con el desarrollo de la investigación, creatividad e innovación.

  3. Satellite Assessment of Bio-Optical Properties of Northern Gulf of Mexico Coastal Waters Following Hurricanes Katrina and Rita.

    Science.gov (United States)

    Lohrenz, Steven E; Cai, Wei-Jun; Chen, Xiaogang; Tuel, Merritt

    2008-07-10

    The impacts of major tropical storms events on coastal waters include sediment resuspension, intense water column mixing, and increased delivery of terrestrial materials into coastal waters. We examined satellite imagery acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS) ocean color sensor aboard the Aqua spacecraft following two major hurricane events: Hurricane Katrina, which made landfall on 29 August 2005, and Hurricane Rita, which made landfall on 24 September. MODIS Aqua true color imagery revealed high turbidity levels in shelf waters immediately following the storms indicative of intense resuspension. However, imagery following the landfall of Katrina showed relatively rapid return of shelf water mass properties to pre-storm conditions. Indeed, MODIS Aqua-derived estimates of diffuse attenuation at 490 nm (K_490) and chlorophyll (chlor_a) from mid-August prior to the landfall of Hurricane Katrina were comparable to those observed in mid-September following the storm. Regions of elevated K_490 and chlor_a were evident in offshore waters and appeared to be associated with cyclonic circulation (cold-core eddies) identified on the basis of sea surface height anomaly (SSHA). Imagery acquired shortly after Hurricane Rita made landfall showed increased water column turbidity extending over a large area of the shelf off Louisiana and Texas, consistent with intense resuspension and sediment disturbance. An interannual comparison of satellite-derived estimates of K_490 for late September and early October revealed relatively lower levels in 2005, compared to the mean for the prior three years, in the vicinity of the Mississippi River birdfoot delta. In contrast, levels above the previous three year mean were observed off Texas and Louisiana 7-10 d after the passage of Rita. The lower values of K_490 near the delta could be attributed to relatively low river discharge during the preceding months of the 2005 season. The elevated levels off Texas and

  4. RITA--Registry of Industrial Toxicology Animal data: the application of historical control data for Leydig cell tumors in rats.

    Science.gov (United States)

    Nolte, Thomas; Rittinghausen, Susanne; Kellner, Rupert; Karbe, Eberhard; Kittel, Birgit; Rinke, Matthias; Deschl, Ulrich

    2011-11-01

    Historical data for Leydig cell tumors from untreated or vehicle treated rats from carcinogenicity studies collected in the RITA database are presented. Examples are given for analyses of these data for dependency on variables considered to be of possible influence on the spontaneous incidence of Leydig cell tumors. In the 7453 male rats available for analysis, only one case of a Leydig cell carcinoma was identified. The incidence of Leydig cell adenomas differed markedly between strains. High incidences of close to 100% have been found in F344 rats, while the mean incidence was 4.2% in Sprague-Dawley rats and 13.7% in Wistar rats. Incidences in Wistar rats were highly variable, primarily caused by different sources of animals. Mean incidences per breeder varied from 2.8 to 39.9%. Analyses for the dependency on further parameters have been performed in Wistar rats. In breeders G and I, the Leydig cell tumor incidence decreased over the observation period and with increasing mean terminal body weight. The incidence of Leydig cell tumors increased with mean age at necropsy and was higher in studies with dietary admixture compared to gavage studies. These parameters had no effect on Leydig cell tumor incidence in breeders A and B. Animals from almost all breeders had a considerably higher mean age at necropsy when bearing a Leydig cell adenoma than animals without a Leydig cell adenoma. Studies with longitudinal trimming of the testes had a higher incidence than studies with transverse trimming. The observed dependencies and breeder differences are discussed and explanations are given. Consequences for the use of historical control data are outlined. With the retrospective analyses presented here we were able to confirm the published features of Leydig cell adenomas and carcinomas. This indicates that the RITA database is a valuable tool for analyses of tumors for their biological features. Furthermore, it demonstrates that the RITA database is highly beneficial for

  5. Satellite Assessment of Bio-Optical Properties of Northern Gulf of Mexico Coastal Waters Following Hurricanes Katrina and Rita

    Directory of Open Access Journals (Sweden)

    Merritt Tuel

    2008-07-01

    Full Text Available The impacts of major tropical storms events on coastal waters include sediment resuspension, intense water column mixing, and increased delivery of terrestrial materials into coastal waters. We examined satellite imagery acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS ocean color sensor aboard the Aqua spacecraft following two major hurricane events: Hurricane Katrina, which made landfall on 29 August 2005, and Hurricane Rita, which made landfall on 24 September. MODIS Aqua true color imagery revealed high turbidity levels in shelf waters immediately following the storms indicative of intense resuspension. However, imagery following the landfall of Katrina showed relatively rapid return of shelf water mass properties to pre-storm conditions. Indeed, MODIS Aqua-derived estimates of diffuse attenuation at 490 nm (K_490 and chlorophyll (chlor_a from mid-August prior to the landfall of Hurricane Katrina were comparable to those observed in mid-September following the storm. Regions of elevated K_490 and chlor_a were evident in offshore waters and appeared to be associated with cyclonic circulation (cold-core eddies identified on the basis of sea surface height anomaly (SSHA. Imagery acquired shortly after Hurricane Rita made landfall showed increased water column turbidity extending over a large area of the shelf off Louisiana and Texas, consistent with intense resuspension and sediment disturbance. An interannual comparison of satellite-derived estimates of K_490 for late September and early October revealed relatively lower levels in 2005, compared to the mean for the prior three years, in the vicinity of the Mississippi River birdfoot delta. In contrast, levels above the previous three year mean were observed off Texas and Louisiana 7-10 d after the passage of Rita. The lower values of K_490 near the delta could be attributed to relatively low river discharge during the preceding months of the 2005 season. The elevated levels

  6. ATIVISMO JUDICIAL E ESTADO DE DIREITO

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Dieder Reverbel

    2009-04-01

    Full Text Available O presente trabalho insere-se na Teoria do Estado e no Direito Constitucional. Parte da natural sociabilidade do humano para demonstrar que o Estado de Direito nasce para servir a pessoa, e esta abdica parte de sua liberdade em prol de um convívio harmônico e pacífico dentro da sociedade. Delimita, mesmo que não desenvolva, o que entende ser os princípios de Estado de Direito. Após, insere o estudo dentro das duas principais famílias de direito: common law e romano-germânica; apresentando o princípío prevalente em cada uma delas: legalidade e processualidade. Desenvolve distinção de McILWIAN entre  jurisdictio y gubernaculum, pois o Estado de Direito só pode ser aquele que delimite e proteja uma área restrita à  Política, e uma área restrita ao  Direito. Por fim, antes da conclusão e da bibliografia, mostramos  os  entraves que o  ativismo judicial  – inclusive colacionando jurisprudências – tem gerado para o florescimento de um Estado de Direito racional.

  7. Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro.

    Science.gov (United States)

    Burmakin, Mikhail; Shi, Yao; Hedström, Elisabeth; Kogner, Per; Selivanova, Galina

    2013-09-15

    Restoration of the p53 function in tumors is a promising therapeutic strategy due to the high potential of p53 as tumor suppressor and the fact that established tumors depend on p53 inactivation for their survival. Here, we addressed the question whether small molecule RITA can reactivate p53 in neuroblastoma and suppress the growth of neuroblastoma cells in vitro and in vivo. The ability of RITA to inhibit growth and to induce apoptosis was shown in seven neuroblastoma cell lines. Mechanistic studies were carried out to determine the p53 dependence and the molecular mechanism of RITA-induced apoptosis in neuroblastoma, using cell viability assays, RNAi silencing, co-immunoprecipitation, qPCR, and Western blotting analysis. In vivo experiments were conducted to study the effect of RITA on human neuroblastoma xenografts in mice. RITA induced p53-dependent apoptosis in a set of seven neuroblastoma cell lines, carrying wild-type or mutant p53; it activated p53 and triggered the expression of proapoptotic p53 target genes. Importantly, p53 activated by RITA inhibited several key oncogenes that are high-priority targets for pharmacologic anticancer strategies in neuroblastoma, including N-Myc, Aurora kinase, Mcl-1, Bcl-2, Wip-1, MDM2, and MDMX. Moreover, RITA had a strong antitumor effect in vivo. Reactivation of wild-type and mutant p53 resulting in the induction of proapoptotic factors along with ablation of key oncogenes by compounds such as RITA may be a highly effective strategy to treat neuroblastoma. ©2013 AACR.

  8. LA NATURALEZA CONTRADICTORIA DEL ESTADO MEXICANO

    Directory of Open Access Journals (Sweden)

    Carlos Báez Silva

    2002-01-01

    Full Text Available En el artículo se aborda el tema de la naturaleza del Estado mexicano, partiendo de la teoría de la contradicción del Estado capitalista adaptada al caso nacional. Se critican las posiciones tradicionales y se sostiene que la contradicción esencial del Estado en México consistió en su labor modernizadora mediante prácticas autoritarias, puesto que se institucionalizó la incertidumbre, entendido esto no como el desconocimiento del nombre del ganador de un proceso electoral preestablecido, sino como el uso y abuso de la discrecionalidad con que se gobernaba en México, la cual se convirtió en una verdadera institución, en el sentido económico del término.

  9. The effects of Hurricanes Katrina and Rita on seabed polycyclic aromatic hydrocarbon dynamics in the Gulf of Mexico.

    Science.gov (United States)

    Mitra, Siddhartha; Lalicata, Joseph J; Allison, Mead A; Dellapenna, Timothy M

    2009-06-01

    To assess the extent to which Hurricanes Katrina and Rita affected polycyclic aromatic hydrocarbons (PAH) in the Gulf of Mexico (GOM), sediment cores were analyzed in late 2005 from: a shallow shelf, a deeper shelf, and a marsh station. Sediment geochronology, fabric, and geochemistry show that the 2005 storms deposited approximately 10cm of sediment to the surface of a core at 5-12A. Bulk carbon geochemistry and PAH isomers in this top layer suggest that the source of sediment to the top portion of core 5-12A was from a relatively more marine area. Particulate PAHs in the marsh core (04M) appeared unaffected by the storms while sediments in the core from Station 5-1B (deeper shelf) were affected minimally (some possible storm-derived deposition). Substantial amounts of PAH-laden particles may have been displaced from the seabed in shallow areas of the water column in the GOM by these 2005 storms.

  10. Recent infection testing algorithm (RITA) applied to new HIV diagnoses in England, Wales and Northern Ireland, 2009 to 2011.

    Science.gov (United States)

    Aghaizu, A; Murphy, G; Tosswill, J; DeAngelis, D; Charlett, A; Gill, O N; Ward, H; Lattimore, S; Simmons, Rd; Delpech, V

    2014-01-16

    In 2009, Public Health England (PHE) introduced the routine application of a recent infection testing algorithm (RITA) to new HIV diagnoses, where a positive RITA result indicates likely acquisition of infection in the previous six months. Laboratories submit serum specimens to PHE for testing using the HIV 1/2gO AxSYM assay modified for the determination of HIV antibody avidity. Results are classified according to avidity index and data on CD₄ count, antiretroviral treatment and the presence of an AIDS-defining illness. Between 2009 and 2011, 38.4% (6,966/18,134) of new HIV diagnoses in England, Wales and Northern Ireland were tested. Demographic characteristics of those tested were similar to all persons with diagnosed HIV. Overall, recent infection was 14.7% (1,022/6,966) and higher among men who have sex with men (MSM) (22.3%, 720/3,223) compared with heterosexual men and women (7.8%, 247/3,164). Higher proportions were among persons aged 15-24 years compared with those ≥50 years (MSM 31.2% (139/445) vs 13.6% (42/308); heterosexual men and women 17.3% (43/249) vs 6.2% (31/501)). Among heterosexual men and women, black Africans were least likely to have recent infection compared with whites (4.8%, 90/1,892 vs 13.3%, 97/728; adjusted odds ratio: 0.6; 95% CI: 0.4-0.9). Our results indicate evidence of ongoing HIV transmission during the study period, particularly among MSM.

  11. Analisis TLC entre Colombia y Estados Unidos: Estados de Virginia y Washington

    OpenAIRE

    Pulecio Leon, Gloria Daniela

    2016-01-01

    el punto central de esta investigación será identificar las principales fortalezas y oportunidades de las empresas colombianas frente al Tratado de Libre Comercio con Estados Unidos, con miras al desarrollo de un proceso de exportación no tradicional e internacionalización, en los estados de Virginia y Washington. Para esto debemos primero reconocer las oportunidades que el mercado colombiano ha aprovechado en los estados de Virginia y Washington, segundo revisar si el tratado de libre ...

  12. Cooperação no APL de Santa Rita do Sapucaí.

    Directory of Open Access Journals (Sweden)

    Ana Rosa de Sousa

    2015-02-01

    Full Text Available Neste trabalho, apresentam-se os principais resultados de pesquisa na qual se investigaram os construtos explicativos das relações de cooperação entre as empresas integrantes do arranjo produtivo local (APL localizado na cidade de Santa Rita do Sapucaí, em Minas Gerais. Para tanto, recuperaram-se alguns aspectos da gênese, do desenvolvimento e da configuração do referido arranjo. Posteriormente, foi elaborada uma proposta teórico-metodológica que serviu de referência para a produção de explicações sobre relações entre os construtos cooperação, confiança, benefícios, entre outros. Para testar e validar a referida proposta, aplicaram-se duas técnicas de análise multivariada: análise fatorial e regressão polinomial. As análises dos resultados da pesquisa evidenciaram a existência de correlações que indicam percepção positiva dos gestores em relação à governança promovida no âmbito do arranjo produtivo e aos benefícios advindos da cooperação. Estes últimos são vistos pelos gestores como geradores de algumas vantagens individuais e coletivas para as empresas participantes da pesquisa. Finalmente, os resultados desta pesquisa contrariam algumas formulações da proposta teórico-metodológica utilizada para explicar as relações de confiança construídas entre as empresas que atuam numa mesma base territorial. Indicam ainda que esse APL exemplificaria bem a importância de dois elementos institucionais: a governança (no caso, Sindicato das Indústrias de Aparelhos Elétricos, Eletrônicos e Similares do Vale da Eletrônica – Sindvel – e poder público local e a interveniência de entidades educacionais que, além de assegurarem a qualificação da mão de obra, assumiram a tarefa de incubar empresas. Não parece inapropriado afirmar que o APL deve a sua criação e, mesmo, o seu desenvolvimento à atuação desses entes, conjuminada com a ação de pessoas visionárias, que ocuparam cargos diretivos

  13. Estados Unidos: do Iraque ao Brasil

    Directory of Open Access Journals (Sweden)

    Virgílio Caixeta Arraes

    2010-12-01

    Full Text Available O presente artigo busca analisar os recentes temas recorrentes na política externa norte-americana, caracterizada pela “guerra contra o terror”, e seus impactos para a agenda a ser discutida na vindoura visita do presidente dos Estados Unidos, Geoge W. Bush, ao Brasil.

  14. Acepciones de la responsabilidad extracontractual del Estado

    Directory of Open Access Journals (Sweden)

    María Eugenia Soto

    2012-09-01

    Full Text Available El objetivo del artículo consiste en determinar las acepciones de la responsabilidad extracontractual del Estado previstas en la Constitución de la República Bolivariana de Venezuela de 1999. La metodología utilizada es la investigación documental, sustentada en el método analítico y la técnica del análisis de contenido. Las fuentes para la recolección de información atienden a tres ámbitos: constitucional, doctrinal y jurisprudencial. Se concluye que la responsabilidad extracontractual del Estado es un sistema de acepciones entendido como valor superior, principio general del derecho público, deber constitucional del Estado en ejercicio de cualquier función pública, derecho subjetivo público de fuerza, rango o valor constitucional, garantía constitucional perteneciente al particular o administrado,integrante de cualquier sociedad democrática y de justicia, para exigir por vía administrativa o jurisdiccional la indemnización de daños y perjuicios, materiales y morales, causados en su situación jurídica -derecho subjetivo e interés legítimo o interés jurídico actual- o en sus bienes muebles o inmuebles imputables al funcionamiento, normal o anormal, de los entes y órganos del Estado.El Tribunal Supremo de Justicia en Sala Político-Administrativa establece una doctrina jurisprudencial iuspublicista sobre las acepciones de la responsabilidad extracontractual del Estado. El calificativo iuspublicista obedece a la circunstancia de que la Constitución de la República Bolivariana de Venezuela de 1999 constituye el instrumento normativo contentivo de las determinadas acepciones o significados.

  15. Estado e controle nas prisões

    Directory of Open Access Journals (Sweden)

    Analía Soria Batista

    Full Text Available Este artigo analisa o problema da produção do controle e da ordem em prisões brasileiras, utilizando as perspectivas histórica e sociológica, e levanta a hipóteses de que, no Brasil, convivem duas modalidades de construção da ordem e do controle nas prisões. Uma delas, minoritária, baseia-se na prerrogativa do Estado na gestão do dia a dia prisional. A outra é relativa à negociação da pacificação do presídio entre o Estado e as lideranças dos presos. Embora, no primeiro caso, a prerrogativa do Estado possa ser vinculada às condições institucionais adequadas e, no segundo (negociação entre o estado e as lideranças dos presos às condições precárias dos presídios, como superlotação, número reduzido de agentes penitenciários, entre outros, a análise apontou que ambas as modalidades traduzem formas de relacionamentos e interações sociais historicamente produzidas entre o Estado e a sociedade, que remetem à fundação da República, recriadas através do habitus dos atores sociais, não se restringindo exclusivamente ao espaço social das prisões.

  16. Metodología para la elaboración de diseños instruccionales del Sistema de Educación a Distancia: caso Universidad del Zulia.

    Directory of Open Access Journals (Sweden)

    Engels Ortega

    2013-12-01

    Full Text Available El objetivo de la investigación, es diseñar una metodología adaptada a las nuevas tendencias educativas para la elaboración de los diseños instruccionales que han de soportar el Sistema de Educación a Distancia de la Universidad del Zulia (SEDLUZ. Se desarrolla una investigación no experimental-transeccional descriptiva con modalidad de campo. La población seleccionada para el análisis se conformó en dos grupos: los recursos humanos adscritos al SEDLUZ, así como las fuentes de documentos curriculares y oficiales de la dependencia. Se aplicó la técnica para el estudio cuantitativo apoyado en la estadística descriptiva y el análisis cualitativo de contenido. Los resultados de esta investigación permiten visualizar las características de la metodología vigente al ser confrontada con los datos aportados por los instrumentos y los referentes teóricos de la temática estudiada. Finalmente, se evidencia la necesidad de actualizar la metodología de gestión del Sistemas de Estudios a Distancia de LUZ, con base a las nuevas tendencias educativas y los avances tecnológicos, por tal motivo se propuso la adecuación del proceso metodológico para la elaboración de diseños instruccionales adaptados en función de las necesidades de las demandas de la institución y por ende las tendencias actuales. Para los efectos se presentan las tablas donde se visualizan los insumos y los resultados esperados para cada fase analizada.

  17. Crossing Canadian Cultural Borders: A study of the Aboriginal/White Stereotypical Relations in George Ryga's The Ecstasy of Rita Joe

    Directory of Open Access Journals (Sweden)

    Maram M. Samman

    2017-12-01

    Full Text Available This paper traces the intercultural journey of a young Aboriginal girl into the hegemonic white society. Rita Joe crossed the imaginary border that separates her reserve from the other Canadian society living in the urban developed city. Through this play, George Ryga aims at achieving liberation and social equality for the Aboriginals who are considered a colonized minority in their land. The research illustrates how Ryga represented his personal version of the colonial Aboriginal history to provide an empowering body narrative that supports their identity in the present and resists the erosion of their culture and tradition. The play makes very strong statements to preserve the family, history and local heritage against this forced assimilation. It tells the truth as its playwright saw it. The play is about the trail of Rita Joe after she moved from her reserve in pursuit of the illusion of the city where she thought she would find freedom and social equality. In fact the audience and the readers are all on trial. Ryga is pointing fingers at everyone who is responsible for the plights of the Aboriginals as it is clear in the play. He questions the Whites’ stereotypical stand against the Aboriginals. The play is a direct criticism of the political, social and cultural systems in Canada. The paper reveals Aboriginals' acts of opposition to racism, assimilation and colonization as represented in The Ecstasy of Rita Joe.

  18. Eye of the storm: analysis of shelter treatment records of evacuees to Acadiana from Hurricanes Katrina and Rita.

    Science.gov (United States)

    Caillouet, L Philip; Paul, P Joseph; Sabatier, Steven M; Caillouet, Kevin A

    2012-01-01

    The objective of this study is to gain insight into the medical needs of disaster evacuees, through a review of experiential data collected in evacuation shelters in the days and weeks following Hurricanes Katrina and Rita in 2005, to better prepare for similar events in the future. Armed with the information and insights provided herein, it is hoped that meaningful precautions and decisive actions can be taken by individuals, families, institutions, communities, and officials should the Louisiana Gulf Coast-or any other area with well-known vulnerabilities-be faced with a future emergency. Demographic and clinical data that were recorded on paper documents during triage and treatment in evacuation shelters were later transcribed into a computerized database management system, with cooperation of the Department of Health Information Management at The University of Louisiana at Lafayette. Analysis of those contemporaneously collected data was undertaken later by the Louisiana Center for Health Informatics. Evacuation shelters, Parish Health Units, and other locations including churches and community centers were the venue for ad hoc clinics in the Acadiana region of Louisiana. The evacuee-patients-3,329 of them-whose information is reflected in the subject dataset were among two geographically distinct but similarly distressed groups: 1) evacuees from Hurricane Katrina that devastated New Orleans and other locales near Louisiana and neighboring states in late August 2005 and 2) evacuees from Hurricane Rita that devastated Southwest Louisiana and neighboring areas of Texas in September 2005. Patient data were collected by physicians, nurses, and other volunteers associated with the Operation Minnesota Lifeline (OML) deployment during the weeks following the events. Volunteer clinicians from OML provided triage and treatment services and documented those services as paper medical records. As the focus of the OML "mission of mercy" was entirely on direct individually

  19. The provenance and Sm/Nd Model ages of siliciclastic supracrustal rocks of the Faina and Santa Rita Greenstone belts, Goias, Brazil

    International Nuclear Information System (INIS)

    Resende, Marcelo Goncalves; Jost, Hardy; Lima, Bruno Eustaquio Moreira; Teixeira, Alexandre de Amorim

    1999-01-01

    The Faina and Santa Rita greenstone belts are two N 60 deg C W trending synclinoria separated by a N 30 deg C E strike-slip fault and rest allochtonous on the adjacent Uva and Caicara granite-gneiss complexes. The belts are made up of lower metakomatiites, followed by metabasalts and thick metasedimentary sequences deposited under contrasting paleogeographic settings. In Faina, the sequence consists of two complete shelf cycles, the first resting on basalts by an erosional unconformity. In Santa Rita, the basalts give gradually place to carbonaceous metashales, unconformably overlain by metarhythmites. Provenance based on trace element geochemistry, mineral chemistry of chloride and muscovite, source-are modeling and REE elements indicate that protoliths of the first shelf cycle of Faina and the carbonaceous metashales of Santa Rita formed under the influence of a source area dominated by mafic ultramafic rocks, whilst during the sedimentation of the second shelf cycle and the metarhythmites of Santa Rita the source-area was dominated by TTG granitoids. Sm-Nd model ages of the lower sedimentary packages vary between 3.0 and 2.8 Ga and the upper between 2.7 and 2.6 Ga. These intervals coincide, respectively, with the estimated age of the underlying, and with the Sm-Nd, Rb-Sr e U-Pb ages of the main granitoids and gneisses of the adjacent complexes. The same data indicate that, during the sedimentation of the first shelf cycle of Faina and the carbonaceous metashales of Santa Rita, both basins had independent source-areas, but shared the same source during the upper sections. Weathering nature and intensity of the source-area calculated by means of geochemical a data suggest that the dramatic change of provenance from the lower to the upper sections is due to the shift from tectonically stable to unstable regimes, interpreted as resulting from the emergence of the island arc whose roots are represented by the adjacent granite-gneiss complexes. (author)

  20. Gerardo Molina y el Estado providente

    Directory of Open Access Journals (Sweden)

    Cataño , Gonzalo

    2004-12-01

    Full Text Available En este ensayo Gonzalo Cataño examina la visión del Estado del notable pensador y dirigente socialista colombiano, Gerardo Molina. Ofrece una breve información biográfica y comenta su enfoque sobre las funciones del aparato estatal. Aunque en la exposición predomina un tono crítico, muestra que las limitaciones de un analista inteligente de los asuntos públicos son más instructivas que las consideraciones correctas de un comentarista trivial de la política. En este trabajo se denomina por Estado providente ¿conocido también como asistencial o de bienestar¿ al que garantiza niveles mínimos de ingreso, salud, alimentación, vivienda, educación y trabajo, como derecho político y no como beneficencia.

  1. Estado e controle nas prisões

    OpenAIRE

    Batista, Analía Soria

    2009-01-01

    Este artigo analisa o problema da produção do controle e da ordem em prisões brasileiras, utilizando as perspectivas histórica e sociológica, e levanta a hipóteses de que, no Brasil, convivem duas modalidades de construção da ordem e do controle nas prisões. Uma delas, minoritária, baseia-se na prerrogativa do Estado na gestão do dia a dia prisional. A outra é relativa à negociação da pacificação do presídio entre o Estado e as lideranças dos presos. Embora, no primeiro caso, a prerrogativa d...

  2. Hurricanes Katrina and Rita and the Department of Veterans Affairs: a conceptual model for understanding the evacuation of nursing homes.

    Science.gov (United States)

    Dobalian, Aram; Claver, Maria; Fickel, Jacqueline J

    2010-01-01

    Hurricanes Katrina and Rita exposed significant flaws in US preparedness for catastrophic events and the nation's capacity to respond to them. These flaws were especially evident in the affected disaster areas' nursing homes, which house a particularly vulnerable population of frail older adults. Although evacuation of a healthcare facility is a key preparedness activity, there is limited research on factors that lead to effective evacuation. Our review of the literature on evacuation is focused on developing a conceptual framework to study future evacuations rather than as a comprehensive assessment of prior work. This paper summarizes what is known thus far about disaster response activities of nursing homes following natural and human-caused disasters, describes a conceptual model to guide future inquiry regarding this topic, and suggests future areas of research to further understand the decision-making process of nursing home facilitators regarding evacuating nursing home residents. To demonstrate the utility of the conceptual model and to provide guidance about effective practices and procedures, this paper focuses on the responses of Veterans Health Administration (VHA) nursing homes to the 2 hurricanes. Quarantelli's conceptual framework, as modified by Perry and Mushkatel, is useful in guiding the development of central hypotheses related to the decision-making that occurred in VA nursing homes and other healthcare facilities following Hurricanes Katrina and Rita. However, we define evacuation somewhat differently to account for the fact that evacuation may, in some instances, be permanent. Thus, we propose modifying this framework to improve its applicability beyond preventive evacuation. We need to better understand how disaster plans can be adapted to meet the needs of frail elders and other residents in nursing homes. Moreover, we must address identified gaps in the scientific literature with respect to health outcomes by tracking outcomes over time

  3. The Santa Rita Shear Zone: Major Mesozoic deformation along the western flank of the White-Inyo Range, CA

    Energy Technology Data Exchange (ETDEWEB)

    Brudos, T.C.; Paterson, S.R. (Univ. of Southern California, Los Angeles, CA (United States). Dept. of Geological Sciences)

    1993-04-01

    The Santa Rita Shear Zone (SRSZ), briefly described by Ross (1967), deforms the western part of the 164 Ma Santa Rita Flat pluton (SRFP), located SSE of Big Pine, CA. The SRSZ comprises a subvertical zone of solid-state deformation (strike N15E) over an area at least 13 km long by 2--3 km wide. Exposure of the shear zone is limited to the north and west by overlying Quaternary volcanics and basin fill within the Late Cenozoic Owens Valley graben. The SRSZ is larger than its present outcrop extent: strain magnitudes are highest within the westernmost exposures. The SRSZ along this western margin is a continuous zone of deformation comprising a mm-scale solid-state foliation containing igneous feldspars flattened into ovals with > 10:1 aspect ratios. The authors have identified three dike phases within the SRFP: (1) minor NE-striking Phase 1 dikes, comprising cm-scale aplites; (2) widespread m-scale Phase 2 dikes, which strike N10E; and (3) m-scale NW-striking Phase 3 mafic dikes. The Phase 1 and Phase 3 dikes are pre- and post-tectonic respectively; observations described below indicate the Phase 2 dikes are syn- to post-deformation. Deformation becomes localized along the Phase 2 dikes -- which are parallel to the orientation of the main body of the shear zone. Solid-state fabrics imposed on the Phase 2 dikes formed at higher temperatures than those within the SRFP, and in the east the SRFP is deformed only within a few cm of the dikes. They surmise syntectonic emplacement of the dikes into dislocational surfaces within the SRSZ, followed by solid-state deformation of the cooling dikes. Several workers have suggested the dikes within the SRFP are part of the 148 Ma independence dike swarm (referring to the Phase 2 or 3 dikes). If correct, this correlation indicates a Jurassic age for the SRSZ. Radiometric analyses of the dikes are in progress.

  4. Ventajas y placeres secretos de estados depresivos

    Directory of Open Access Journals (Sweden)

    Günter Jursch

    2005-04-01

    Full Text Available Las depresiones y los estados depresivos varían de una persona a otra. Si se quiere trabajar para mejorar la situación de las víctimas de estos males, sería indicado saber en qué se distinguen los diferentes fenómenos y dónde se encuentra la causa. Pues las depresiones a menudo cumplen una función que suele aparecer camuflada.

  5. Estado de Exceção

    Directory of Open Access Journals (Sweden)

    Angelita Matos Souza

    2010-09-01

    Full Text Available

    Abordaremos duas obras de Giorgio Agamben - Homo Sacer (2002 e Estado de Exceção (2004. Nas duas obras a noção-chave é a de exceção, definida em relação à vida “política” dos indivíduos, mas na primeira (2002 interessa a exceção identificada à vida nua dos “súditos”, enquanto a segunda (2004 volta-se mais ao Estado, em sua dimensão biopolítica e (ahistórica. Recorreremos a Thomas Hobbes e Carl Schmitt a fim de melhor compreender o autor, indicando que, além da dívida para com Hobbes, sua idéia de exceção e a crítica ao estado de direito deve muito a Carl Schmitt.

  6. LA INCIDENCIA DEL CONCEPTO ESTADO DE DERECHO Y ESTADO SOCIAL DE DERECHO EN LA INDEPENDENCIA JUDICIAL

    Directory of Open Access Journals (Sweden)

    Luisa Fernanda García Lozano

    2011-01-01

    Full Text Available El siguiente artículo tiene como objetivo realizar un análisis de la incidencia del tipo de Estado en la independencia judicial. En la primera parte, se aborda de forma integral el concepto de Estado de derecho haciendo énfasis en las características históricas y neoinstitucionales que han sido el fundamento de imposición en los últimos años. En la segunda parte, se estudia la trasformación del paradigma jurídico colombiano con su consagración en un Estado Social de Derecho, sus alcances en el campo constitucional y, la necesidad de realizar un estudio específico de este tema.

  7. Modelo Vectorial para la Inferencia del Estado Cognitivo de Pacientes en Estados Derivados del Coma

    Directory of Open Access Journals (Sweden)

    Esteban Velásquez R.

    2014-06-01

    Full Text Available La forma tradicional de evaluar el estado de conciencia de un individuo, ha sido mediante la aplicación de estímulos y el análisis de sus respuestas, sin embargo, esta técnica se ve limitada cuando el individuo es incapaz de responder evidentemente ante un estímulo, como es el caso de los pacientes en estados derivados del coma. En estos casos, se requiere de una conexión directa con el cerebro del paciente para detectar una respuesta. Por consiguiente, en este artículo se desarrolla y analiza un modelo computacional basado en los principios de las máquinas de soporte vectorial (MSV, para inferir el estado cognitivo de pacientes en estados derivados del coma, mediante la utilización de un equipo de electroencefalografía comercial. Los resultados obtenidos, mostraron que el modelo logró clasificar correctamente una tarea cognitiva en al menos cuatro de cada cinco pruebas en pacientes de control, lo que se traduce en la obtención de un sistema de bajo costo para el análisis del estado de conciencia y para la posible comunicación con algunos pacientes en estados derivados del coma mediante protocolos médicos definidos. De esta manera, este sistema se presenta como un gran aporte para las clínicas y centros hospitalarios, como herramienta potencial de diagnóstico para este tipo de pacientes.

  8. The Muralla Pircada: an ancient Andean debris flow retention dam, Santa Rita B archaeological site, Chao Valley, Northern Peru

    Science.gov (United States)

    Brooks, William E.; Willett, Jason C.; Kent, Jonathan D.; Vasquez, Victor; Rosales, Teresa

    2005-01-01

    Debris flows caused by El Niño events, earthquakes, and glacial releases have affected northern Perú for centuries. The Muralla Pircada, a northeast-trending, 2.5 km long stone wall east of the Santa Rita B archaeological site (Moche-Chimú) in the Chao Valley, is field evidence that ancient Andeans recognized and, more importantly, attempted to mitigate the effects of debris flows. The Muralla is upstream from the site and is perpendicular to local drainages. It is 1–2 m high, up to 5 m wide, and is comprised of intentionally-placed, well-sorted, well-rounded, 20–30 cm cobbles and boulders from nearby streams. Long axes of the stones are gently inclined and parallel local drainage. Case-and-fill construction was used with smaller cobbles and pebbles used as fill. Pre-Muralla debris flows are indicated by meter-sized, angular boulders that were incorporated in-place into construction of the dam and are now exposed in breeches in the dam. Post-Muralla debris flows in the Chao Valley are indicated by meter-sized, angular boulders that now abut the retention dam.

  9. USGS environmental characterization of flood sediments left in the New Orleans area after Hurricanes Katrina and Rita, 2005--Progress Report

    Science.gov (United States)

    Plumlee, Geoffrey S.; Meeker, Gregory P.; Lovelace, John K.; Rosenbauer, Robert J.; Lamothe, Paul J.; Furlong, Edward T.; Demas, Charles R.

    2006-01-01

    Introduction: The flooding in the greater New Orleans area that resulted from Hurricanes Katrina and Rita in September, 2005, left behind accumulations of sediments up to many centimeters thick on streets, lawns, parking lots, and other flat surfaces. These flood sediment deposits have been the focus of extensive study by the US Environmental Protection Agency (EPA) and Louisiana Department of Environmental Quality (LDEQ) due to concerns that the sediments may contain elevated levels of heavy metals, organic contaminants, and microbes. The U.S. Geological Survey (USGS) is characterizing a limited number of flood sediment samples that were collected on September 15-16 and October 6-7, 2005, from the greater New Orleans area by personnel from the USGS Louisiana Water Science Center in Baton Rouge. Small samples (< 3 pints each) of wet to dry flood sediment were collected from 11 localities around downtown New Orleans on September 15, 2005, and two large samples (40 pints each) of wet flood sediment were collected from the Chalmette area on September 16. Twelve additional samples (8-10 pints each) were collected from New Orleans, Slidell, Rigolets, and Violet on October 6 and 7. The USGS characterization studies of these flood sediments are designed to produce data and interpretations regarding how the sediments and any contained contaminants may respond to environmental processes. This information will be of use to cleanup managers and DoI/USGS scientists assessing environmental impacts of the hurricanes and subsequent cleanup activities.

  10. A CONSTRUÇÃO DO LUGAR DE VIVER: PROJETO DE ASSENTAMENTO SANTA RITA EM JATAÍ – GO

    Directory of Open Access Journals (Sweden)

    Roberta Costa ROCHA

    2015-07-01

    Full Text Available A pesquisa da qual resulta este artigo tem como objeto o assentamento rural, enquanto modo de resistência camponesa para a sua permanência no campo, e a construção do lugar de viver nesse assentamento. Os atores da pesquisa são as famílias do Projeto de Assentamento Santa Rita, localizado no município de Jataí-GO, que, em um novo meio, constroem o seu lugar, dando-lhe significação e ressignificação enquanto lugar camponês. O estudo do lugar abre perspectivas para se pensar o viver e os processos de apropriação do espaço. Metodologicamente, os dados primários foram levantados através de entrevistas semiestruturadas e de aplicação de questionários e os dados secundários foram obtidos através de pesquisas bibliográficas, no intuito de aprofundar a discussão proposta.

  11. Observations of the structure and evolution of surface and flight-level wind asymmetries in Hurricane Rita (2005)

    Science.gov (United States)

    Rogers, Robert; Uhlhorn, Eric

    2008-11-01

    Knowledge of the magnitude and distribution of surface winds, including the structure of azimuthal asymmetries in the wind field, are important factors for tropical cyclone forecasting. With its ability to remotely measure surface wind speeds, the stepped frequency microwave radiometer (SFMR) has assumed a prominent role for the operational tropical cyclone forecasting community. An example of this instrument's utility is presented here, where concurrent measurements of aircraft flight-level and SFMR surface winds are used to document the wind field evolution over three days in Hurricane Rita (2005). The amplitude and azimuthal location (phase) of the wavenumber-1 asymmetry in the storm-relative winds varied at both levels over time. The peak was found to the right of storm track at both levels on the first day. By the third day, the peak in flight-level storm-relative winds remained to the right of storm track, but it shifted to left of storm track at the surface, resulting in a 60-degree shift between the surface and flight-level and azimuthal variations in the ratio of surface to flight-level winds. The asymmetric differences between the surface and flight-level maximum wind radii also varied, indicating a vortex whose tilt was increasing.

  12. Red de investigación estudiantil de la Universidad del Zulia (REDIELUZ. Una política académica que enlaza la investigación y la tecnología.

    Directory of Open Access Journals (Sweden)

    Luz Maritza Reyes

    2013-12-01

    Full Text Available Una mirada al escenario universitario mundial y nacional demanda una política académica de convergencia entre investigación y tecnología, que permita fijar posiciones responsables ante los riesgos que amenazan la supervivencia humana y los requerimientos de cambios de una nueva generación de jóvenes impactados por el volumen y la expansión de la información. Esto, compromete a las universidades venezolanas con el reordenamiento de sus estructuras organizativa-funcional. El propósito de este estudio, se centra en analizar el enlace entre investigación y tecnología desde la praxis de la Red de Investigación Estudiantil de la Universidad del Zulia (Redieluz, como política académica. La metódica se inscribe, en un enfoque hermenéutico que interpreta la teoría y praxis de la Redieluz, articulando contextos, ideas, normas y experiencias, de las cuales se develan competencias de investigación y estrategias tecnológicas en contribución con la formación del pregrado. Los resultados develan, la pertinencia de trasladar la estructura académica del programa Redieluz a otras universidades del país, por ser un programa de transformación universitaria (tecnológica -científica y humana, que supera las experiencias aisladas que han limitado la articulación entre la formación profesional, la investigación con la tecnología y la acción ciudadana con impacto significativo en la inserción del egresado al mercado de trabajo. A manera de conclusión, la complejidad que caracteriza la estructura de la Redieluz, le adhiere capacidad de autoorganización mediada por la información e investigación.

  13. A Cáritas brasileira e a Economia Popular Solidária: O Agente de Cáritas e a Caridade Libertadora (Brazilian Caritas and the Popular Solidarity Economy: The Agent of Caritas and the Charity Liberating) - DOI: 10.5752/P.2175-5841.2013v11n32p1506

    OpenAIRE

    Joannes Paulus Silva Forte; Alicia Ferreira Gonçalves

    2013-01-01

    O presente artigo analisa as ligações entre a Cáritas Brasileira e a Economia Popular Solidária a partir do trabalho do Agente de Cáritas. A problemática central do artigo remete às representações sociais que esses Agentes constroem em seus relatos sobre os princípios da Teologia da Libertação que norteiam os projetos em economia solidária da referida instituição religiosa. A metodologia de base qualitativa e etnográfica consistiu na realização da revisão bibliográfica, consulta a materiais i...

  14. A LÍNGUA EM ESTADO GASOSO

    Directory of Open Access Journals (Sweden)

    E. M de Melo e Castro

    1998-10-01

    Full Text Available Guimarães Rosa, numa carta a João Condé publicada no Jornal de Letras e Artes de 21 de Julho de 1946 deixou esta sugestão: "Mas,ainda haveria mais, se possível (sonhar é fácil, João Condé, realizar é que são elas ...: além dos estados líquidos e sólidos, porque não tentartrabalhar a língua em estado gasoso?!"Nesta comunicação tratarei de averiguar o que possa ser o estado gasosoda língua quer sob o ponto de vista físico quer sob o ponto de vista metafórico.Sob o ponto de vista físico devem ser considerados dois momentos: o daciência geralmente divu lgada na época em que Guimarães Rosa fez essasugestão, c o da atua l ciência do Caos, tendo em consideração os movimentosbrownianos das moléculas descritos na teoria cin ética dos gases.Sob o ponto de vista metafórico, o uso de uma terminologia interd isciplinar,à luz dos referidos conceitos da ciência, pode contribu ir para delinearuma possível concepção linguística que esteja de acordo com aprática c o uso criativo diferenciados da língua portuguesa, não só noBrasil c em Portugal, mas também nos países africanos de língua portuguesa, configurando-se ass im uma possível teoria cinética da língua.

  15. Gerardo Molina y el Estado providente

    OpenAIRE

    Cataño, Gonzalo

    2008-01-01

    En este ensayo Gonzalo Cataño examina la visión del Estado del notable pensador y dirigente socialista colombiano, Gerardo Molina. Ofrece una breve información biográfica y comenta su enfoque sobre las funciones del aparato estatal. Aunque en la exposición predomina un tono crítico, muestra que las limitaciones de un analista inteligente de los asuntos públicos son más instructivas que las consideraciones correctas de un comentarista trivial de la política. En este trabajo se denomina por Est...

  16. La fatiga como estado motivacional subjetivo

    OpenAIRE

    D. Cárdenas; J. Conde-González; J.C. Perales

    2017-01-01

    Actualmente no existe consenso sobre los factores que determinan la aparición de la fatiga. Hay factores que se derivan exclusivamente del esfuerzo físico, otros que dependen del esfuerzo mental que este lleva aparejado, y otros de los resultados de la tarea que se está realizando. Como consecuencia, se han desarrollado diferentes modelos explicativos que pretenden aunar las diferentes razones de su aparición. No obstante, la tendencia actual es entender la fatiga como un estado motivacion...

  17. La fatiga como estado motivacional subjetivo

    Directory of Open Access Journals (Sweden)

    D. Cárdenas

    2017-03-01

    No obstante, la tendencia actual es entender la fatiga como un estado motivacional complejo cuyo origen tiene lugar en numerosos procesos fisiológicos y psicológicos que sirven para regular el esfuerzo y proteger al organismo de daños graves. Los objetivos de la presente revisión narrativa son analizar los diferentes enfoques existentes para el estudio y la explicación de la fatiga, establecer el vínculo con el concepto de carga de entrenamiento y justificar la importancia de evaluar las repercusiones de la carga mental para conseguir una adecuada planificación y control del proceso de entrenamiento.

  18. Ciencias de la complejidad: estado actual

    OpenAIRE

    Cancino Quintero, David Eduardo

    2015-01-01

    Los aportes teóricos y aplicados de la complejidad en economía han tomado tantas direcciones y han sido tan frenéticos en las últimas décadas, que no existe un trabajo reciente, hasta donde conocemos, que los compile y los analice de forma integrada. El objetivo de este proyecto, por tanto, es desarrollar un estado situacional de las diferentes aplicaciones conceptuales, teóricas, metodológicas y tecnológicas de las ciencias de la complejidad en la economía. Asimismo, se pretende analizar las...

  19. Los "intelectuales" y el Estado Novo

    Directory of Open Access Journals (Sweden)

    Luís REIS TORGAL

    2010-02-01

    Full Text Available RESUMEN: El concepto de “intelectual” es difícil de definir y sin duda se debate constantemente. Sin embargo, es importante reflexionar sobre él a fin de comprender su significado y los problemas que implica. Sea como fuere, a un Estado autoritario “moderno” se le supone una única ideología que tiene que difundirse por medio de una propaganda bien organizada, proceso en el que los intelectuales desempeñan un papel significativo. El “Nuevo Estado” de Salazar encaja en esta categoría y sin duda el conocimiento acerca de sus “intelectuales” es fundamental. En este artículo, el objetivo es proporcionar algunos ejemplos interesantes de “intelectuales” o de simples “funcionarios políticos” con inclinación intelectual a fin de indicar el sentido y complejidad de un estudio con una dimensión distinta sobre este asunto. A este fin han sido seleccionadas tres personalidades responsables de la actividad ideológica y cultural de gran relieve en el Estado de Salazar: António Ferro, João Ameal y Costa Brochado. Palabras clave: Estado Novo; Authotitarianism; Salazar, António de Oliveira; Intellectuals; Ferro, António; Brochado, Idalino da Costa; Ameal, João. ABSTRACT: The concept of the “intellectual” is difficult to define and undoubtedly constantly debated. It is nevertheless important to reflect on it in order to understand its meaning and the problems involved with it. Be that as it may, a “modern” authoritarian State presumes a single ideology which has to be diffused by means of well-organised propaganda, in which process “intellectuals” play a significant role. Salazar’s “New State” fits this category and, undoubtedly, knowledge about its “intellectuals” is fundamental. The objective in this article is to provide some interesting examples of “intellectuals” or simple “political functionar- ies” with an intellectual bent so as to indicate the sense and complexity of a study of a

  20. Pteridófitas do Parque Estadual de Vassununga, Santa Rita do Passa Quatro (SP, Brasil. Gleba Pé-de-Gigante. Pteridophytes from Vassununga State Park, Santa Rita do Passa Quatro, SP, Brazil. Gleba Pé-de-Gigante.

    Directory of Open Access Journals (Sweden)

    Áurea Maria Therezinha COLLI

    2004-12-01

    Full Text Available Neste trabalho foi realizado um levantamentode pteridófitas na Gleba Pé-de-Gigante do ParqueEstadual de Vassununga, localizado no municípiode Santa Rita do Passa Quatro, sob as coordenadas21º36’39,01054’’S e 47º37’03,46727’’W. As coletasforam realizadas em três trilhas, denominadasTrilha do Meliponário, Trilha do Córrego Paulicéiae Trilha da Torre. Foram reconhecidas 15 espéciesde pteridófitas pertencentes a 7 famílias. Dessas,as mais representativas foram Polypodiaceae eThelypteridaceae com quatro espécies cada,e Pteridaceae e Schizaeaceae que apresentaramduas espécies cada. Das 15 espécies registradas9 apresentam distribuição bastante restrita, ocorrendoapenas na Trilha do Córrego Paulicéia. Por outrolado, Microgramma squamulosa (Kaulf. de laSota, Pleopeltis angusta Willd e Polypodiumpolypodioides (L. Watt são as espécies deocorrência mais ampla. Em todas as trilhas hápteridófitas, sendo que a Trilha do CórregoPaulicéia é a mais rica, e a Trilha da Torre a maispobre em número de espécies. As pteridófitasocorrem no cerrado “sensu stricto”, cerradão e nafloresta de galeria. A maior diversidade de espéciesfoi encontrada na floresta de galeria.This work presents a pteridophyticalsurvey carried out at the Gleba Pé-de-Gigante ofthe Vassununga State Park, in the municipality ofSanta Rita do Passa Quatro (21º36’39.01054’’Sand 47º37’03.46727’’W. Collections wereaccomplished at three trails called “Trilha doMeliponário, Trilha do Córrego Paulicéia andTrilha da Torre ”. Fifteen species of pteridophytespertaining to 7 families were recognized. From these,the most representative ones were Polypodiaceaeand Thelypteridaceae, with 4 species each, andPteridaceae and Schizaeaceae, with two specieseach. From the 15 species registered, nine present avery restricted distribution occurring only in the“Trilha do Córrego Paulic��ia”, Microgrammasquamulosa, Pleopeltis angusta and

  1. Pteridófitas do Parque Estadual da Vassununga, Santa Rita do Passa Quatro (SP, Brasil. Glebas Capetinga Leste e Capetinga Oeste. Pteridophytes from Vassununga State Park, Santa Rita do Passa Quatro, SP, Brazil. Glebas Capetinga Leste and Capetinga Oeste.

    Directory of Open Access Journals (Sweden)

    Áurea Maria Therezinha COLLI

    2004-06-01

    Full Text Available Neste trabalho foi realizado umlevantamento de pteridófitas nas Glebas CapetingaLeste e Capetinga Oeste do Parque Estadual daVassununga, localizado no município de Santa Rita doPassa Quatro, sob as coordenadas 21º41’00’’ –21º41’21’’S e 47º34’37’’ – 47º39’39’’W. As coletasforam realizadas em quatro trilhas, denominadasTrilha da Mina, Trilha do Ribeirão Bebedouro,Trilha dos Jequitibás e Trilha do Córrego da Gruta.Foram reconhecidas 34 espécies de pteridófitaspertencentes a 10 famílias. Destas, as maisrepresentativas foram Polypodiaceae e Thelypteridaceaecom seis espécies cada e Aspleniaceae e Pteridaceaeque apresentaram cinco espécies cada. Das 34espécies registradas 10 apresentam distribuiçãobastante restrita, ocorrendo apenas na Trilha da Mina.Por outro lado, Polypodium polypodioides (L. Watt,Pteris denticulata var. denticulata Sw eThelypteris dentata (Forssk. E. St. John são asespécies de ocorrência mais ampla. Em todas astrilhas há pteridófitas, sendo que a Trilha da Minaé a mais rica e a Trilha do Ribeirão Bebedouro amais pobre em número de espécies. As pteridófitasocorrem na floresta estacional semidecidual e namata ciliar. A maior diversidade de espécies foiencontrada na floresta estacional semidecidual.This work presents a pteridophyticalsurvey carried out at Glebas Capetinga Leste andCapetinga Oeste at Vassununga State Park,Santa Rita do Passa Quatro county, (21º41’00’’ –21º41’21’’S and 47º34’37’’ – 47º39’39’’W.Collections were done at four places called “Trilhada Mina”, “Trilha do Ribeirão Bebedouro”, “Trilhados Jequitibás” and “Trilha do Córrego da Gruta.”Thirty-four species of pteridophytes pertaining to10 families were recognized. Among them, themost representative ones were Polypodiaceaeand Thelypteridaceae, with six species each,and Aspleniaceae and Pteridaceae, with fivespecies each. Considering the 34 species registered,10

  2. Usefulness of the admission electrocardiogram to predict long-term outcomes after non-ST-elevation acute coronary syndrome (from the FRISC II, ICTUS, and RITA-3 [FIR] Trials)

    DEFF Research Database (Denmark)

    Damman, Peter; Holmvang, Lene; Tijssen, Jan G P

    2012-01-01

    Instability in Coronary Artery Disease (FRISC II), Invasive Versus Conservative Treatment in Unstable Coronary Syndromes (ICTUS), and Randomized Intervention Trial of Unstable Angina 3 (RITA-3) patient-pooled database, 5,420 patients with NSTE-ACS with qualitative ECG data, of whom 2,901 had quantitative data...... the addition of quantitative characteristics to a model including qualitative characteristics. In conclusion, in the FRISC II, ICTUS, and RITA-3 NSTE-ACS patient-pooled data set, admission ECG characteristics provided long-term prognostic value for cardiovascular death or myocardial infarction. Quantitative...

  3. Multi-proxy Characterization of Two Recent Storm Deposits Attributed to Hurricanes Rita and Ike in the Chenier Plain of Southwestern Louisiana

    Science.gov (United States)

    Yao, Q.; Liu, K. B.; Ryu, J.

    2017-12-01

    The Chenier Plain in southwestern Louisiana owes its origin to dynamic depositional processes that are dominated by delta-switching of the Mississippi River to the east, while frequent hurricane activities also play an important role in its geomorphology and sedimentary history. However, despite several studies in the literature, the sediment-stratigraphic characteristics of recent or historic hurricane deposits are still not well documented from the Chenier Plain. In 2005 and 2008, Hurricane Rita (category 3) and Ike (category 2) made landfall on the coasts of Louisiana and Texas. Remote sensing images confirm that the Rockefeller Wildlife Refuge, located at the east end of the Louisiana Chenier Plain, was heavily impacted by both hurricanes. We analyzed the lithology and chemical stratigraphy of three 30 cm sediment monoliths (ROC-1, ROC-2, and ROC-3) recovered from a coastal saltmarsh in the Rockefeller Wildlife Refuge to identify the event deposits attributed to these two storms. Each monolith contains 2 distinct light-colored clastic sediment layers imbedded in brown organic clay. The loss-on-ignition and X-ray fluorescence results show that the hurricane layers have increased contents of Ca, Sr, Zr, and carbonates and decreased contents of water and organics. Surprisingly, despite its greater intensity and more severe impacts, Hurricane Rita left a much thinner storm deposit than did Hurricane Ike in all monoliths. Satellite data reveal that Hurricane Rita caused significant coastal erosion and shoreline recession, rendering the sampling sites much closer to the beach and ocean and therefore more prone to storm surges and overwash deposition than when Hurricane Ike struck three years later. Our results suggest that site-to-sea distance, which affects a study site's paleotempestological sensitivity, can play a bigger role in affecting the thicknesses of storm deposits than the intensity of the hurricane.

  4. A Influência de um protocolo de coordenação motora no estado depressivo e estado cognitivo

    OpenAIRE

    Costa, Cândida; Pinheira, Vítor; Rodrigues, Abel

    2014-01-01

    Introdução: São conhecidos os efeitos positivos do exercício terapêutico no estado depressivo e estado cognitivo do idoso. Objetivo: Este estudo teve como objetivos avaliar e comparar os efeitos de um protocolo de coordenação motora, com a duração de 8 semanas, duas vezes por semana, 50 minutos cada sessão, no estado depressivo e estado cognitivo. Metodologia: 30 idosos (81,43 ±8,97 anos), 66,7% mulheres, clinicamente estáveis e capazes de realizar marcha, numa amostra por conveniência...

  5. Florística em um hectare de cerrado stricto sensu na ARIE - cerrado Pé-de-Gigante, Santa Rita do Passa Quatro, SP

    OpenAIRE

    Weiser, Veridiana de Lara; Godoy, Silvana Aparecida Pires de

    2001-01-01

    Foi realizado um levantamento florístico em um ha de cerrado stricto sensu, na parte norte da ARIE - Cerrado Pé-de-Gigante, Santa Rita do Passa Quatro, São Paulo. Foram coletados 428 espécimes em fase reprodutiva, em vinte e cinco excursões de coleta, durante o período de novembro de 1996 a abril de 1998. A listagem florística obtida apresenta 141 espécies, distribuídas em 109 gêneros e 49 famílias. As famílias mais representativas foram: Leguminosae, Asteraceae, Malpighiaceae e Myrtaceae. A ...

  6. Looking for the Silver Lining: Benefit Finding after Hurricanes Katrina and Rita in Middle-Aged, Older, and Oldest-Old Adults

    OpenAIRE

    Stanko, Katie E.; Cherry, Katie E.; Ryker, Kyle S.; Mughal, Farra; Marks, Loren D.; Brown, Jennifer Silva; Gendusa, Patricia F.; Sullivan, Marisa C.; Bruner, John; Welsh, David A.; Su, L. Joseph; Jazwinski, S. Michal

    2015-01-01

    Looking for potentially positive outcomes is one way that people cope with stressful events. In two studies, we examined perceived “silver linings” after the 2005 Hurricanes Katrina and Rita among indirectly affected adults. In Study 1, middle-aged (ages 47–64 years), older (ages 65–89 years), and oldest-old (ages 90–95 years) adults in the Louisiana Healthy Aging Study (LHAS) responded to an open-ended question on perceived silver linings in a longitudinal assessment carried out during the i...

  7. La crisis financiera de los Estados unidos

    Directory of Open Access Journals (Sweden)

    Héctor J. Rubini

    2009-08-01

    Full Text Available El trabajo ofrece una visión comprehensiva de la presente crisis económica de los Estados Unidos, con énfasis en los determinantes y factores de riesgo que se encuentran en el sistema financiero de ese país.Se concluye que: a ha sido una crisis de desarrollo gradual, pero no prevista por la mayoría de los economistas, sorprendiendo pro su impacto recesivo y la diseminación internacional observada desde mediados de 2008, b es claro (ex post que Estados Unidos debe introducir reformas institucionales en su sistema financiero y en sus mercados de capitales, pero sus autoridades no parecen tener claro cuáles, c se trata de una crisis del sistema financiero, no de las instituciones jurídicas del capitalismo; d en materia macroeconómica, aún bajo el maquillaje de "reglas flexibles", es claro el fracaso de la discrecionalidad en la políticas monetaria, así como también el del implícito enfoque de la "autorregulación" de los mercados de la llamada "doctrina Greenspan", e Esta crisis ha evidenciado las notables falencias de la moderna macroeconomía dinámica basada en el paradigma de las expectativas racionales y de los mercados eficientes.

  8. Pb and Sr isotopic systematics of some basalts and sulfides from the East Pacific Rise at 210N (project RITA)

    International Nuclear Information System (INIS)

    Vidal, P.; Clauer, N.

    1981-01-01

    Tholeiitic basalts and sulfide deposits from the 'Cyana' and 'Alvin' diving programs (RITA project) on the East Pacific Rise were analyzed for Pb and Sr isotopes. The basalt data plot within the field defined previously by other East Pacific Rise basalts ( 206 Pb/ 204 Pb: 18.35-18.58; 207 Pb/ 204 Pb: 15.48-15.53; 208 Pb/ 204 Pb: 37.8-38.1; 87 Sr/ 86 Sr: 0.7022-0.7025). Pb, U and Sr contents (approx. equal to 0.5, approx. equal to 0.05 and approx. equal to 110 ppm, respectively) and μ values (approx. equal to 6) are typical of MORB, whereas Th/U ratios (approx. equal to 3.5) are significantly higher. The Pb isotopic ratios of the sulfide samples are very homogeneous ( 206 Pb/ 204 Pb approx. equal to 18.47, 207 Pb/ 204 Pb approx. equal to 15.49, 208 Pb/ 204 Pb approx. equal to 37.90), and plot in the middle of the basalt field. This indicates that the sulfide Pb was derived from the basaltic crust without any significant contribution from either seawater or hemipelagic sediments, and the solutions from which the sulfiedes were deposited had uniform Pb isotopic composition. The Pb contents of three sulfide samples is relatively high (170-1310 ppm). The Sr contents of five sulfide samples are widely scattered from 12 to 210 ppm, with 87 Sr/ 86 Sr ratios intermediate between basaltic and seawater values (0.70554 +- 0.00005 to 0.70795 +- 0.00011). Leaching experiments show that both basalt-derived Sr and seawater Sr were present in the solutions which deposited the sulfides. In some cases, Sr was also adsorbed from seawater onto the sulfides following their deposition. Basalt-derived Sr and seawater Sr are also present in associated non-sulfide phases. (orig.)

  9. Sleep deprivation and adverse health effects in United States Coast Guard responders to Hurricanes Katrina and Rita.

    Science.gov (United States)

    Bergan, Timothy; Thomas, Dana; Schwartz, Erica; McKibben, Jodi; Rusiecki, Jennifer

    2015-12-01

    Disaster responders are increasingly called upon to assist in various natural and manmade disasters. A critical safety concern for this population is sleep deprivation; however, there are limited published data regarding sleep deprivation and disaster responder safety. We expanded upon a cross-sectional study of 2695 United States Coast Guard personnel who responded to Hurricanes Katrina and Rita. Data were collected via survey on self-reported timing and location of deployment, missions performed, health effects, medical treatment sought, average nightly sleep, and other lifestyle variables. We created a 4-level sleep deprivation metric based on both average nightly reported sleep (d5hours; >5hours) and length of deployment (d2weeks; >2weeks) to examine the association between sustained sleep deprivation and illnesses, injuries, and symptoms using logistic regression to calculate odds ratios (ORs) and 95% confidence intervals. The strongest, statistically significant positive ORs for the highest sleep deprivation category compared with the least sleep-deprived category were for mental health and neurologic effects, specifically depression (OR=6.76), difficulty concentrating (OR=8.33), and confusion (OR=11.34), and for dehydration (OR=9.0). Injuries most strongly associated with sleep deprivation were twists, sprains, and strains (OR=6.20). Most health outcomes evaluated had monotonically increasing ORs with increasing sleep deprivation, and P tests for trend were statistically significant. Agencies deploying disaster responders should understand the risks incurred to their personnel by sustained sleep deprivation. Improved planning of response efforts to disasters can reduce the potential for sleep deprivation and lead to decreased morbidity in disaster responders. Published by Elsevier Inc.

  10. The provenance and Sm/Nd Model ages of siliciclastic supracrustal rocks of the Faina and Santa Rita Greenstone belts, Goias, Brazil; Proveniencia e idades modelo Sm/Nd das rochas siliciclasticas arqueanas dos greenstone belts de Faina e Santa Rita, Goias

    Energy Technology Data Exchange (ETDEWEB)

    Resende, Marcelo Goncalves [Universidade Catolica de Brasilia, DF (Brazil); Jost, Hardy [Brasilia Univ., DF (Brazil). Inst. de Geociencias; Lima, Bruno Eustaquio Moreira; Teixeira, Alexandre de Amorim

    1999-09-01

    The Faina and Santa Rita greenstone belts are two N 60 deg C W trending synclinoria separated by a N 30 deg C E strike-slip fault and rest allochtonous on the adjacent Uva and Caicara granite-gneiss complexes. The belts are made up of lower metakomatiites, followed by metabasalts and thick metasedimentary sequences deposited under contrasting paleogeographic settings. In Faina, the sequence consists of two complete shelf cycles, the first resting on basalts by an erosional unconformity. In Santa Rita, the basalts give gradually place to carbonaceous metashales, unconformably overlain by metarhythmites. Provenance based on trace element geochemistry, mineral chemistry of chloride and muscovite, source-are modeling and REE elements indicate that protoliths of the first shelf cycle of Faina and the carbonaceous metashales of Santa Rita formed under the influence of a source area dominated by mafic ultramafic rocks, whilst during the sedimentation of the second shelf cycle and the metarhythmites of Santa Rita the source-area was dominated by TTG granitoids. Sm-Nd model ages of the lower sedimentary packages vary between 3.0 and 2.8 Ga and the upper between 2.7 and 2.6 Ga. These intervals coincide, respectively, with the estimated age of the underlying, and with the Sm-Nd, Rb-Sr e U-Pb ages of the main granitoids and gneisses of the adjacent complexes. The same data indicate that, during the sedimentation of the first shelf cycle of Faina and the carbonaceous metashales of Santa Rita, both basins had independent source-areas, but shared the same source during the upper sections. Weathering nature and intensity of the source-area calculated by means of geochemical a data suggest that the dramatic change of provenance from the lower to the upper sections is due to the shift from tectonically stable to unstable regimes, interpreted as resulting from the emergence of the island arc whose roots are represented by the adjacent granite-gneiss complexes. (author)

  11. Centroamérica: el estado de las ciencias sociales.

    OpenAIRE

    Torres Rivas, Edelberto

    2011-01-01

    Este artículo trata sobre los estados de las ciencias sociales en Centroamérica; por el cual el autor aborda temas como: El posmodernismo, crisis de la pérdida del sentido ortodoxo , El Marxismo, estudios sobre la democracia, revoluciones, estados fallidos y paralelos todos estos relacionados a países centroamericanos.

  12. Disfagia y estado nutricional en ancianos institucionalizados

    Directory of Open Access Journals (Sweden)

    Esmeralda Carrillo Prieto

    Full Text Available La disfagia es un síndrome geriátrico por su alta prevalencia en ancianos (mayor en la población institucionalizada que favorece la desnutrición y compromete la seguridad, debido al riesgo de aspiración de alimentos. Objetivos: Conocer el estado nutricional de los ancianos institucionalizados que presentan disfagia, residentes en instituciones sociosanitarias de carácter público de la provincia de Toledo. Metodología: Estudio descriptivo y transversal (enero-febrero 2015. Población de estudio: personas de 65 años o más, residentes en instituciones sociosanitarias públicas de Toledo con disfagia. Criterios de exclusión: nutrición enteral o parenteral y situación terminal. Variables: edad, sexo, valoración antropométrica, dieta, restricciones dietéticas, suplemento nutricional y estado nutricional con Mini Nutritional Assessment (MNA. Resultados: Un total de 33 ancianos. Media de edad: 86,73 años (DT 7,74. Mujeres: 84,84%. MNA medio: 13,85 (DT = 3,5, riesgo de desnutrición: 18,18% y desnutrición: 78,78%. IMC: bajo peso 36,36%. Un 51,51% no sabe si ha perdido peso, un 96,97% con deterioro cognitivo, un 81,82% toma 4 fármacos o más, un 39,4% toma menos de 3 comidas diarias completas, un 27,27% toma frutas o verduras menos de 2 veces al día, un 78,79% menos de 6 vasos de líquidos al día. Un 90,9% solo movilidad cama-sillón y un 78,79% necesita ayuda para alimentarse. Dieta túrmix: 90,9%, sin restricciones dietéticas: 84,84%. Sin suplementos nutricionales: 75,75%. Diferencias estadísticamente significativas: MNA-independencia en movilidad (p = 0,008, MNA-problemas neuropsicológicos (p = 0,01, MNA-independencia en alimentación (p = 0,001 y MNA-suplementos nutricionales (p = 0,028. MNA-polimedicación: tendencia a sufrir desnutrición (p = 0,903. Conclusiones: En la valoración nutricional de la población mayor institucionalizada con disfagia se concluye la existencia de una gran proporción de ancianos con un estado

  13. MEGAMINERIA, DESTERRITORIALIZACION DEL ESTADO Y BIOPOLITICA

    Directory of Open Access Journals (Sweden)

    Mirta Alejandra Antonelli

    2011-12-01

    Full Text Available Este artículo desarrolla algunos aspectos relativos a la mega-minería en tanto modelo biopolítico, a partir del marco regulatorio sancionado a comienzos de los 90 en la región. Focaliza para ello en dos macro-fenómenos que se verifican en su acelerada implantación: la desestatalización del territorio y la desterritorialización del Estado. A partir de este marco se propone señalar ciertas estrategias desplegadas por los dispositivos hegemónicos que vienen procurando su legitimación, y destacar un conjunto de consecuencias que de ellas se derivan para la condición de existencia de subjetividades y cuerpos que distingue al extractivismo mega-minero: el vivir en la corteza.

  14. La reforma del estado: democracia y gobernabilidad

    Directory of Open Access Journals (Sweden)

    Rafael de la CRUZ

    2009-11-01

    Full Text Available RESUMEN: El autor muestra, desde la experiencia venezolana, que la decadencia de las instituciones políticas populistas tiene la mayor responsabilidad en la crisis que atraviesa América Latina. La reforma del Estado, en sus aspectos económicos, políticos y administrativos, debe entenderse como una oportunidad para restablecer la gobernabilidad y preservar la democracia en el continente.ABSTRACT: By looking at the Venezuelan experience, the author shows that the decline of the populist political institutions is the main cause of the crisis that Latin America is going through. The reform of the State in its economic, political and administrative aspects must be understood as an opportunity to restore the governance of the system and to preserve the democracy in the continent.

  15. Aspectos puntuales del estado vegetativo persistente

    OpenAIRE

    Hodelín Tablada, Ricardo

    2013-01-01

    El estado vegetativo persistente es una condición clínica caracterizada por la ausencia completa de conciencia sobre uno mismo y el entorno, unido a ciclos de sueño-vigilia, con preservación total o parcial de las funciones hipotalámicas y autonómicas del tallo encefálico. En el presente artículo, el autor discute aspectos puntuales sobre la entidad clínica, basado en su experiencia y en la revisión de la bibliografía sobre el tema; igualmente se exponen elementos clínicos y epidemiológicos d...

  16. Estado, Estado de Derecho y Violencia Armada en Colombia (2000-2011

    Directory of Open Access Journals (Sweden)

    Jerónimo Ríos Sierra

    2013-03-01

    Full Text Available Para la superación sostenible de la violencia armada en Colombia, con o sin negociaciones, la noción de “paz positiva” es imprescindible. El  éxito militar muestra su precariedad frente al necesario fortalecimiento del Estado de Derecho en un escenario de urgencias sociales, políticas y económicas. Durante la última década, tanto la Política de Seguridad Democrática como el Plan Colombia han priorizado el fortalecimiento del Estado en términos de seguridad, control territorial y fortaleza militar. Ello se debe a la idea de concebir la superación de la violencia armada en términos de ausencia de conflicto.Problemas tales como inequidad social, pobreza, parapolítica, connivencias de sectores políticos y del Estado con narcotráfico y actores armados, persistencia de la violencia guerrillera, paramilitarismo creciente, violaciones a los Derechos Humanos (DDHH y el Derecho Internacional Humanitario (DIH y/o desplazamiento forzado, tal y como se pondrá de manifiesto, persisten como desafíos por superar, más allá de la seguridad, si se pretende aspirar a una verdadera consecución de la paz en Colombia.

  17. Using Instrument Simulators and a Satellite Database to Evaluate Microphysical Assumptions in High-Resolution Simulations of Hurricane Rita

    Science.gov (United States)

    Hristova-Veleva, S. M.; Chao, Y.; Chau, A. H.; Haddad, Z. S.; Knosp, B.; Lambrigtsen, B.; Li, P.; Martin, J. M.; Poulsen, W. L.; Rodriguez, E.; Stiles, B. W.; Turk, J.; Vu, Q.

    2009-12-01

    Improving forecasting of hurricane intensity remains a significant challenge for the research and operational communities. Many factors determine a tropical cyclone’s intensity. Ultimately, though, intensity is dependent on the magnitude and distribution of the latent heating that accompanies the hydrometeor production during the convective process. Hence, the microphysical processes and their representation in hurricane models are of crucial importance for accurately simulating hurricane intensity and evolution. The accurate modeling of the microphysical processes becomes increasingly important when running high-resolution models that should properly reflect the convective processes in the hurricane eyewall. There are many microphysical parameterizations available today. However, evaluating their performance and selecting the most representative ones remains a challenge. Several field campaigns were focused on collecting in situ microphysical observations to help distinguish between different modeling approaches and improve on the most promising ones. However, these point measurements cannot adequately reflect the space and time correlations characteristic of the convective processes. An alternative approach to evaluating microphysical assumptions is to use multi-parameter remote sensing observations of the 3D storm structure and evolution. In doing so, we could compare modeled to retrieved geophysical parameters. The satellite retrievals, however, carry their own uncertainty. To increase the fidelity of the microphysical evaluation results, we can use instrument simulators to produce satellite observables from the model fields and compare to the observed. This presentation will illustrate how instrument simulators can be used to discriminate between different microphysical assumptions. We will compare and contrast the members of high-resolution ensemble WRF model simulations of Hurricane Rita (2005), each member reflecting different microphysical assumptions

  18. El rol del Estado en el Derecho Internacional Privado

    Directory of Open Access Journals (Sweden)

    Ruben B. Santos Belandro

    2015-09-01

    Full Text Available Contenido: Introducción. El Estado como instrumento de la racionalidad jurídica. Primer contragolpe en favor de la restauración de los valores irreflexivos: Savigny. La racionalidad jurídica al servicio del Estado: el neo-territorialismo rioplatense. Segundo contragolpe contra el racionalismo formal: el materialismo de Quintín Alfonsín. El reconocimiento de otras formas de racionalidad descartan al Estado como el único intérprete. ¿Y el futuro?

  19. Estado, derecho y nuevo orden mundial

    Directory of Open Access Journals (Sweden)

    Orlando José Cadrazco Salcedo

    2009-01-01

    Full Text Available Resumen:Con el surgimiento de actores internacionales no estatales, aunque no solo por ellos, la política internacional seha convertido en global. Las esferas de influencia de los Estados también se encuentran bajo revisión práctica ypolítica. Si se entiende la gobernabilidad global como un proyecto normativo, basado en la cooperación internacional,la conciliación de intereses y la justicia, debería desarrollarse los mecanismos para tematizar y combatirlos problemas globales que están en el ángulo muerto del horizonte de los actores globales fuertes. El término«globalización» apareció por primera vez en un diccionario enciclopédico en idioma inglés en el año 1961; hastamediados de los años 70 había aparecido en el título de muy pocos libros; desde los 80 se convirtió en una nociónclave en el debate de las ciencias sociales, y en los 90 entró en el léxico cotidiano.Palabras claves:Derecho Internacional Público; Globalización; Nuevo Orden Mundial; Estados; Economía; Naciones; Política; Gobernabilidad.Abstract:With the emergence of international non-state actors, but not just for them, international politics has become global.Spheres of influence of states also are under review policy and practice. If global governance is understood as apolicy, based on international cooperation, reconciliation of interests and justice should develop mechanisms tofocus on and combat global problems that are in the blind spot of the horizon of strong global players. The term “globalization”first appeared in an encyclopedic dictionary in English in the year 1961 until the mid-70s had appearedin the title of very few books; from the 80 became a key concept in the debate social sciences, and at 90 enteredthe everyday lexicon.Keywords:Public International Law, Globalization, New World Order; States; Economy; Nations; Policy; Governance

  20. La Reforma del Estado y la Social democracia

    OpenAIRE

    Cárdenas, Manuel José

    2000-01-01

    En este artículo el autor sostiene que la gran tarea política de esta primera década del siglo XXI es la reconstrucción del Estado colombiano. Destaca que cuando existe una crisis importante en el sistema político su origen debe buscarse en el Estado o en el mercado. La Depresión del año 30 se produjo por un mal funcionamiento del mercado y la gran crisis de los años 80 por el colapso del Estado. Esta crisis en realidad comprendió varias crisis: fiscal, del modelo de intervención del Estado e...

  1. El papel del Estado en el microfinanciamiento

    Directory of Open Access Journals (Sweden)

    Celia Hernández Cortés

    2015-01-01

    Full Text Available La intervención del Estado tradicionalmente se ha justificado al afirmar que: “el propósito de toda intervención es mejorar el nivel de bienestar de la sociedad y, en el caso de la intervención en los mercados financieros, ese objetivo adopta la forma de aseguramiento de solvencia y eficiencia del sistema” (Martínez, 2002: 747. Más allá de las limitaciones y críticas que sostenemos en este artículo respecto a la viabilidad de este instrumento de política pública, para incidir sobre los factores estructurales determinantes de la pobreza, que lamentablemente se generaliza y profundiza en la modalidad neoliberal del capitalismo, el propósito de este trabajo es atender los problemas surgidos en el funcionamiento general de las microfinanzas y la necesaria intervención gubernamental, para asegurar la solvencia de las instituciones y la protección de la población usuaria de este tipo de servicios financieros. Se trata, entonces, de una reflexión colectiva de un conjunto de acciones de microfinanciamiento llevadas a cabo en México y en otros países, que podemos denominar complementarias del mercado financiero formal.

  2. Pincio y los Estados Unidos que no son los Estados Unidos

    OpenAIRE

    Zangrilli, Franco

    2015-01-01

    Lo neofantástico en Tommaso Pincio se distingue de lo fantástico posmoderno de nuestros escritores. Se basa en la realidad estadounidense contemporánea; la introduce en un proceso de elaboraciones enfáticas, mezclas, transfiguraciones, y la convierte en el símbolo de otro mundo, de un planeta extraño. Pincio llega a esta operación creativa gracias a su conocimiento de las tradiciones y de las costumbres, de la historia, de la cultura y de la literatura de los Estados Unidos. De todo eso quier...

  3. Síntesis del estado del conocimiento del ciclo de carbono en ecosistemas boscosos de los Estados Unidos

    Science.gov (United States)

    Michael G. Ryan; Mark E. Harmon; Richard A. Birdsey; Christian P. Giardina; Linda S. Heath; Richard A. Houghton; Robert B. Jackson; Duncan C. McKinley; James F. Morrison; Brian C. Murray; Diane E. Pataki; Kenneth E. Skog

    2010-01-01

    Los bosques juegan un papel central en el ciclo de carbono de los Estados Unidos y global. El secuestro de carbono de los bosques de los Estados Unidos, a través de su crecimiento y la cosecha de productos madereros, compensa en la actualidad entre un 12 y un 19% de las emisiones de carbono asociadas al uso de combustible fósil de dicho país. El ciclo natural de un...

  4. Physiographic characterization and land use in Luiz Antônio and Santa Rita do Passa Quatro, SP, throughout the use of remote sensing and GIS

    Directory of Open Access Journals (Sweden)

    Cláudia Nagako Shida

    2012-03-01

    Full Text Available This study characterizes a region of about 82.655 ha, in Luiz Antônio and Santa Rita do Passa Quatro municipalities, SP, according to its physiography, vegetation and land uses, and identifies homogeneous landscape units which could be used for regional planning; the existence of relationships between the regional physiography and present land uses were verified. Using GIS techniques, homogeneous landscape units were identified according to physiography, land uses and native vegetation. The Chi-squaretest revealed significant associations between land uses and physiography, soil type being the most important one. Six homogeneous landscape units were identified, and in most of them, land uses were adequate according to the physiographic features. Agricultural and silvicultural activities are also present in areas of restricted use, where today's land uses should be replaced by more suitable ones.

  5. Chemical constituents in sediment in Lake Pontchartrain and in street mud and canal sediment in New Orleans, Louisiana, following Hurricanes Katrina and Rita, 2005

    Science.gov (United States)

    Van Metre, Peter C.; Wilson, Jennifer T.; Horowitz, Arthur J.; Skrobialowski, Stanley C.; Foreman, William T.; Fuller, Christopher C.; Burkhardt, Mark R.; Elrick, Kent A.; Mahler, Barbara J.; Smith, James J.; Zaugg, Steven D.

    2007-01-01

    Samples of street mud, suspended and bottom sediment in canals discharging to Lake Ponchartrain, and suspended and bottom sediment in the lake were collected and analyzed for chemical constituents to help evaluate the effects of Hurricanes Katrina and Rita and the subsequent unwatering of New Orleans, Louisiana. The approach used for sampling and analysis of chemical data for the study is presented herein. Radionuclides, major and trace elements, and numerous organic compounds in sediment were analyzed. The organic compounds include organochlorine pesticides, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, urban waste indicator compounds, and current-use pesticides. Methods for the analysis of urban waste indicator compounds and current-use pesticides in sediment were developed only recently.

  6. Galls and gall makers in plants from the Pé-de-Gigante Cerrado Reserve, Santa Rita do Passa Quatro, SP, Brazil.

    Science.gov (United States)

    Urso-Guimarães, M V; Scareli-Santos, C

    2006-02-01

    Thirty-six morphologically different types of galls were obtained in leaves, leaflets, veins, petioles, stems, tendrils and flower buds from twenty-five species of plants in the Pé-de-Gigante Reserve, municipality of Santa Rita do Passa Quatro, state of São Paulo, Brazil. The host plant species belong to the closely related families Anacardiaceae, Annonaceae, Asteraceae, Bignoniaceae, Caryocaraceae, Erythroxylaceae, Fabaceae, Malpighiaceae, Melastomataceae, Myrtaceae, Ochnaceae, Polygalaceae, Sapindaceae, Sapotaceae, and Smilacaceae. The most common gall makers included Cecidomyiidae (Diptera), Pteromalidae (Hymenoptera) and Diaspididae (Sternorrhyncha-Hemiptera). This is the first report of galls found in the following plant genera: Gochnatia (Asteraceae), Distictela (Bignoniaceae), Banisteriopsis (Malpighiaceae), Ouratea (Ochnaceae), and Bredemeyera (Polygalaceae). The results of this work contribute to the body of knowledge about the relationship among host plants, gall makers, and the gall morphology of Pé-de-Gigante Cerrado Reserve.

  7. Galls and gall makers in plants from the Pé-de-Gigante Cerrado Reserve, Santa Rita do Passa Quatro, SP, Brazil

    Directory of Open Access Journals (Sweden)

    M. V. Urso-Guimarães

    Full Text Available Thirty-six morphologically different types of galls were obtained in leaves, leaflets, veins, petioles, stems, tendrils and flower buds from twenty-five species of plants in the Pé-de-Gigante Reserve, municipality of Santa Rita do Passa Quatro, state of São Paulo, Brazil. The host plant species belong to the closely related families Anacardiaceae, Annonaceae, Asteraceae, Bignoniaceae, Caryocaraceae, Erythroxylaceae, Fabaceae, Malpighiaceae, Melastomataceae, Myrtaceae, Ochnaceae, Polygalaceae, Sapindaceae, Sapotaceae, and Smilacaceae. The most common gall makers included Cecidomyiidae (Diptera, Pteromalidae (Hymenoptera and Diaspididae (Sternorrhyncha-Hemiptera. This is the first report of galls found in the following plant genera: Gochnatia (Asteraceae, Distictela (Bignoniaceae, Banisteriopsis (Malpighiaceae, Ouratea (Ochnaceae, and Bredemeyera (Polygalaceae. The results of this work contribute to the body of knowledge about the relationship among host plants, gall makers, and the gall morphology of Pé-de-Gigante Cerrado Reserve.

  8. Disaster-related exposures and health effects among US Coast Guard responders to Hurricanes Katrina and Rita: a cross-sectional study.

    Science.gov (United States)

    Rusiecki, Jennifer A; Thomas, Dana L; Chen, Ligong; Funk, Renée; McKibben, Jodi; Dayton, Melburn R

    2014-08-01

    Disaster responders work among poorly characterized physical and psychological hazards with little understood regarding health consequences of their work. A survey administered to 2834 US Coast Guard responders to Hurricanes Katrina and Rita provided data on exposures and health effects. Prevalence odds ratios (PORs) evaluated associations between baseline characteristics, missions, exposures, and health effects. Most frequent exposures were animal/insect vector (n = 1309; 46%) and floodwater (n = 817; 29%). Most frequent health effects were sunburn (n = 1119; 39%) and heat stress (n = 810; 30%). Significant positive associations were for mold exposure and sinus infection (POR = 10.39); carbon monoxide and confusion (POR = 6.27); lack of sleep and slips, trips, falls (POR = 3.34) and depression (POR = 3.01); being a Gulf-state responder and depression (POR = 3.22). Increasing protection for disaster responders requires provisions for adequate sleep, personal protective equipment, and access to medical and psychological support.

  9. Mapping the spatial and temporal dynamics of the velvet mesquite with MODIS and AVIRIS: Case study at the Santa Rita Experimental Range

    Science.gov (United States)

    Kaurivi, Jorry Zebby Ujama

    The general objective of this research is to develop a methodology that will allow mapping and quantifying shrub encroachment with remote sensing. The multitemporal properties of the Moderate Resolution Imaging Spectroradiometer (MODIS) -250m, 16-day vegetation index products were combined with the hyperspectral and high spatial resolution (3.6m) computation of the Airborne Visible-Infrared Imaging Spectrometer (AVIRIS) to detect the dynamics of mesquite and grass/soil matrix at two sites of high (19.5%) and low (5.7%) mesquite cover in the Santa Rita Experimental Range (SRER). MODIS results showed separability between grassland and mesquite based on phenology. Mesquite landscapes had longer green peak starting in April through February, while the grassland only peaked during the monsoon season (July through October). AVIRIS revealed spectral separability, but high variation in the data implicated high heterogeneity in the landscape. Nonetheless, the methodology for larger data was developed in this study and combines ground, air and satellite data.

  10. Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX

    Science.gov (United States)

    Spinnler, C; Hedström, E; Li, H; de Lange, J; Nikulenkov, F; Teunisse, A F A S; Verlaan-de Vries, M; Grinkevich, V; Jochemsen, A G; Selivanova, G

    2011-01-01

    Inactivation of the p53 tumour suppressor, either by mutation or by overexpression of its inhibitors Hdm2 and HdmX is the most frequent event in cancer. Reactivation of p53 by targeting Hdm2 and HdmX is therefore a promising strategy for therapy. However, Hdm2 inhibitors do not prevent inhibition of p53 by HdmX, which impedes p53-mediated apoptosis. Here, we show that p53 reactivation by the small molecule RITA leads to efficient HdmX degradation in tumour cell lines of different origin and in xenograft tumours in vivo. Notably, HdmX degradation occurs selectively in cancer cells, but not in non-transformed cells. We identified the inhibition of the wild-type p53-induced phosphatase 1 (Wip1) as the major mechanism important for full engagement of p53 activity accomplished by restoration of the ataxia telangiectasia mutated (ATM) kinase-signalling cascade, which leads to HdmX degradation. In contrast to previously reported transactivation of Wip1 by p53, we observed p53-dependent repression of Wip1 expression, which disrupts the negative feedback loop conferred by Wip1. Our study reveals that the depletion of both HdmX and Wip1 potentiates cell death due to sustained activation of p53. Thus, RITA is an example of a p53-reactivating drug that not only blocks Hdm2, but also inhibits two important negative regulators of p53 – HdmX and Wip1, leading to efficient elimination of tumour cells. PMID:21546907

  11. Multicenter Phase II Study with Weekly Bendamustine and Paclitaxel as First- or Later-Line Therapy in Patients with Metastatic Breast Cancer: RiTa II Trial.

    Science.gov (United States)

    Loibl, Sibylle; Doering, Gabriele; Müller, Lothar; Grote-Metke, Albert; Müller, Roberto; Tomé, Oliver; Wiest, Wolfgang; Maisch, Andrea; Nekljudova, Valentina; von Minckwitz, Gunter

    2011-12-01

    The combination of bendamustine (B) and paclitaxel (P) as anthracycline-free treatment option in patients with advanced breast cancer has been evaluated in the previous RiTa I trial. The regimen of weekly B 70 mg/m(2) and P 90 mg/m(2) with a pause every 4th week was established as an effective regimen with low toxicity. The aim of the present RiTa II study was to investigate the potential of BP as anthracycline-free combination therapy. The primary objective was to determine the progression-free survival (PFS); secondary endpoints were safety, tolerability, overall response rate (ORR) and overall survival (OS). 26 patients were available, 15 received BP as first-line, 11 as beyond first-line treatment. 27% patients had triple-negative breast cancer (TNBC). Median PFS and OS were 7.3 months (95% confidence interval (CI): 5.5-10.9) and 14.9 months (95% CI: 9.9-22.9), respectively. The 1-year PFS rate was 20.3% and the 1-year OS rate 71.2%. The ORR was 42.3%, including 4 complete and 7 partial remissions. TNBC patients reached an ORR of 71.4%. Anthracycline-pretreated patients showed an ORR of 43.8%, confirming bendamustine's lack of cross-resistance to anthracycline agents. BP represents a favorable option with moderate toxicity in pretreated metastatic breast cancer and offers a possibility for application in anthracycline-pretreated and TNBC patients.

  12. Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX.

    Science.gov (United States)

    Spinnler, C; Hedström, E; Li, H; de Lange, J; Nikulenkov, F; Teunisse, A F A S; Verlaan-de Vries, M; Grinkevich, V; Jochemsen, A G; Selivanova, G

    2011-11-01

    Inactivation of the p53 tumour suppressor, either by mutation or by overexpression of its inhibitors Hdm2 and HdmX is the most frequent event in cancer. Reactivation of p53 by targeting Hdm2 and HdmX is therefore a promising strategy for therapy. However, Hdm2 inhibitors do not prevent inhibition of p53 by HdmX, which impedes p53-mediated apoptosis. Here, we show that p53 reactivation by the small molecule RITA leads to efficient HdmX degradation in tumour cell lines of different origin and in xenograft tumours in vivo. Notably, HdmX degradation occurs selectively in cancer cells, but not in non-transformed cells. We identified the inhibition of the wild-type p53-induced phosphatase 1 (Wip1) as the major mechanism important for full engagement of p53 activity accomplished by restoration of the ataxia telangiectasia mutated (ATM) kinase-signalling cascade, which leads to HdmX degradation. In contrast to previously reported transactivation of Wip1 by p53, we observed p53-dependent repression of Wip1 expression, which disrupts the negative feedback loop conferred by Wip1. Our study reveals that the depletion of both HdmX and Wip1 potentiates cell death due to sustained activation of p53. Thus, RITA is an example of a p53-reactivating drug that not only blocks Hdm2, but also inhibits two important negative regulators of p53 - HdmX and Wip1, leading to efficient elimination of tumour cells.

  13. en el mercado de Estados Unidos

    Directory of Open Access Journals (Sweden)

    Nadima Simón Domínguez

    2004-01-01

    Full Text Available El objetivo de este artículo es analizar el comportamiento de las exportaciones del sector de prendas de vestir (de tejido de punto y de tejido plano en el mercado de Estados Unidos (EUA durante el periodo de 1990 a 2002. Se identifican los principales competidores, las características de ambos mercados y los instrumentos de política comercial utilizados por las empresas estadounidenses para la protección de su industria textil. De igual forma, se hace un análisis de los principales productos de prendas de vestir que nuestro país exportó a EUA clasificándolos por su participación en el mercado de dicho país y por el dinamismo que presentan éstos. También se identifican los factores que inciden en la participación de México en el mercado estadounidense. Se concluye que México incrementó considerablemente sus exportaciones de prendas de vestir a EUA después de la entrada en vigor del TLCAN y de la devaluación del peso mexicano de diciembre de 1994. México es líder en el mercado de aquel país en camisas de algodón y en pantalones de mezclilla, seguido muy de cerca por China. Para mantener la participación de las prendas de vestir de México en dicho mercado, nuestra industria del vestido debe orientarse a la fabricación de paquete completo y de productos de moda con mayor valor agregado.

  14. El estado: un ensayo siempre inconcluso

    Directory of Open Access Journals (Sweden)

    Supelano Alberto

    1989-12-01

    Full Text Available Quienes profesan el marxismo están convencidos de que poseen la teoría completa y definitiva de la sociedad capitalista y el instrumento científico para liberar a la clase obrera de los "grilletes que la encadenan". Su poder explicativo, en el ámbito de la naturaleza y economía del capitalismo industrial, aunque limitado, es innegable sobre todo cuando se lo compara con doctrinas rivales y algunas de sus percepciones fundamentales han sido incorporadas a diversas corrientes del pensamiento contemporáneo. En cambio, como ideología científica al servicio de la emancipación de la clase obrera industrial, ha fracasado rutundamente. Sin excepción, todas las revoluciones populares del siglo XX incluso las que se han hecho en
    nombre de cualquiera de sus variantes locales han ocurrido en países de mayoría campesina, donde las instituciones características de una economía industrial orientada por móviles pecuniarios sólo han tenido un desarrollo incipiente: amplia participación ciudadana, justicia económica de tipo competitivo y crecimiento industrial basado en el descubrimiento y la experimentación. En ninguno de ellos existía una clase obrera industrial amplia y diversificada ejercitada en la lucha por obtener los beneficios del sistema industrial y en todos ellos el poder del estado descansaba en la tradición, el estatus o la fuerza, no en su adaptación a los valores, actitudes y comportamientos que surgen en sociedades urbanas densas, plurales y cambiantes.

  15. Estado nutricional materno y peso al nacer

    Directory of Open Access Journals (Sweden)

    Marianela de la C Prendes Labrada

    2001-02-01

    Full Text Available Se realizó un estudio analítico de cohorte en el Policlínico "Raúl Gómez" entre enero de 1996 y septiembre de 1997 con el objetivo de relacionar el estado nutricional materno con el peso al nacer. Concluyeron el estudio 305 gestantes en las que se determinó edad, hábito de fumar, peso, talla, valoración ponderal inicial, incremento transgestacional y peso al nacer. Se aplicó Chi cuadrado y se determinó el riesgo relativo. El peso adecuado, el incremento transgestacional de 8 kg o más y la talla > o = 150 cm se asociaron con el peso al nacer > o = 3 000 g. La talla menor de 150 cm, peso bajo III y IV y las fumadoras aportaron con mayor frecuencia recién nacidos con peso entre 2 500 y 2 999 g. El riesgo de bajo peso al nacer fue mayor entre las gestantes con peso bajo I-II-III-IV, con incremento transgestacional menor de 8 kg y en las fumadorasAn analytic cohort study was conducted in "Raúl Gómez" Polyclinic between January, 1996, and September, 1997, aimed at relating the maternal nutritional status with birth weight. Age, smoking habit, weight, height, initial ponderal assessment, transgestational weight gain and birth weight were determined among the 305 pregnant women that concluded the study. The adequate weight, the transgestational weight gain of 8 kg or more and the height > or = 150 cm were associated with a birth weight > or = 3000 g. Women with the lowest height of 150 cm, low weight III and IV and the smokers had more frequently newborn infants between 2 500 and 2 999 g. The low birth weight risk was higher among the expectants with low weight I-II-II-IV, with a transgestational weight gain under 8 kg and among smokers

  16. O capital agroindustrial catarinense e o Estado

    Directory of Open Access Journals (Sweden)

    Noeli Pertile

    2011-07-01

    Full Text Available A significativa participação do estado de Santa Catarina na atual produção agroindustrial brasileira, especialmente no setor de carnes, é um fato incontestável. Na mesma direção tem sido a representatividade, cada vez maior, de agroindústrias catarinenses no mercado externo. Assim inseridas, grandes empresas mantêm suas relações de produção, industrialização e comercialização nas distintas escalas geográficas, de modo que essas transições resultem no atendimento às suas demandas e aos seus objetivos. No entanto, para que se chegasse ao estágio atual de engajamento socioespacial e econômico, faz-se necessário analisar o processo de formação e consolidação das agroindústrias de carnes do Oeste catarinense e considerar as diversas mudanças promovidas na base econômica regional, resultado de investimentos de diferentes suportes institucionais e financeiros. Para este artigo, desenvolve-se uma análise crítica e explicativa com base no argumento de que o Estado, tanto em âmbito nacional quanto estadual, dispunha de recursos e de articulações com as agroindústrias para direcionar os investimentos almejados por esse capital industrial e passou a intervir na economia com o intuito de facilitar seu processo de acumulação. Sendo assim, o Estado apresenta-se como suporte para o desenvolvimento do capital privado, no caso analisado o capital agroindustrial. Resumé LE CAPITAL AGRO-INDUSTRIEL CATARINENSE ET L’ÉTAT La significative participation de l’état de Santa Catarina dans l’actuelle production agro-industrielle brésilienne, spécialement le secteur de viandes, est un costume incontesté. Dans le même direction ce a été la représentativité, à chaque fois plus grande, d’entreprises catarinenses dans le marché externe. Ainsi d’insérées, grandes entreprises il maintient leurs relations de production, industrialisation et comer cialisation dans les distinctes échelles géographiques de mani

  17. Estado de exceção em Giorgio Agamben

    Directory of Open Access Journals (Sweden)

    Evandro Pontel

    2017-02-01

    Full Text Available Esta reflexão aborda o estado de exceção enquanto necessidade à existência do direito e como realidade que emerge sempre mais e tende a ser tornar, por fim, regra nas sociedades atuais. Não mais excepcional, mas o padrão de atuação dos Estados que está se generalizando e se misturando com o que era o seu oposto, o estado de direito. Nesta perspectiva, o estado de exceção como paradigma de governo repercute no modo como o direito internacional regula o uso da força pelos Estados. Nesse sentido, a positivação dos princípios da soberania e não-intervenção confere e reforça a autonomia dos governos na condução de seus atos. Da mesma forma, em nome da defesa dos interesses nacionais há um enfraquecimento de iniciativas de cooperação entre os Estados. Frente a estas questões a abordagem agambeniana lança luzes no que tange ao Estado, à política e ao direito, justamente focando as estruturas que legitimam a violência, a arbitrariedade e a suspensão dos direitos, em nome da segurança, a serviço da concentração de poder e de uma lógica de domínio.

  18. Centre cultural Santa Rita

    OpenAIRE

    Boixet Méndez, Oriol; Martín Casado, Sara; Mas Muñoz, Mireia; Montoya Martínez, Jose Ramón; Serena López, Álex; Vera Benjauma, Mercedes

    2013-01-01

    Situada en la comuna de Pelarco, la edificación consta de una superficie construida de 4.295 metros cuadrados. Dividida en 2 patios interiores y diferentes alas, se encuentra en una extensa superficie de terreno. La construcción original está formada por muros de adobe, pilares con base de piedra, fuste y capitel de madera, una techumbre compuesta por cerchas de madera en forma tradicional chilena conocida como tijeral, cubierta, también tradicional, de tejas cerámicas a cuatro ag...

  19. Decadencia del estado de cambios en la posición financiera

    Directory of Open Access Journals (Sweden)

    Diego Ramírez Cardona

    1996-12-01

    Full Text Available Este artículo presenta una descripción de la evolución del estado de cambios en la situación financiera como estado financiero básico en Colombia. Analiza y confronta las normas técnicas de revelación de este estado financiero con las del estado financiero básico, armonizándolas con las normas internacionales. Establece la dualidad de las normas técnicas de revelación entre estado de cambios en la situación financiera y el estado de flujos de efectivo, determinando la duplicidad de estos estados financieros básicos reglamentados en Colombia. Recomienda la eliminación del estado de cambios en la situación financiera como estado financiero básico.

  20. Razón de Estado y razones del Estado, (Decimas Conferencias Aranguren

    Directory of Open Access Journals (Sweden)

    Díaz, Elías

    2002-06-01

    Full Text Available As against bad «reasons of state», both past and present, a number of good reasons of state are put forward here as sound demands for times to come. One of the aims we try to attain is a necessary theoretical and practical retrieval of politics along with culture and ethics in the public field. As against the prevailing untrammelled power of economics -in particular its purportedly one version, namely «scientific capitalism» and the quite lopsided globalization- it becomes mandatory to completely take into account the view-point of general interests (both national and transnational, universal; and, within that framework, legitimate individual interests, mainly those of broad social sections least endowed with bargaining leverage and resources. The ground for those good reasons of state (and reasons, too, for a civil society critically harmonized with the state lies in an ethics of enlightened values of freedom, equality and brotherhood (solidarity, as well as of such security as stems from social cohesion (a conjunction of justice and efficiency.

    Frente a la mala «Razón de Estado», del pasado y del presente, se alegan aquí algunas de las posibles y potenciales buenas razones del Estado, también como exigencias válidas para el futuro. Con ello se pretende coadyuvar a una imprescindible recuperación teórica y práctica de la política y, con ella, de la cultura y de la ética en el espacio público. Ante el actual poder omnimodo e «incontrolado» de la economía, de su versión pretendidamente única, la del «capitalismo científico» y la muy desigual «globalización», se hace necesario tomar completamente en serio la perspectiva de los intereses generales (nacionales y transnacionales, universales: y, dentro de ellos, los legítimos intereses individuales y, en especial, los de aquellos amplios sectores sociales dotados de muchos menos poderes y posibilidades. La ética de los valores ilustrados de libertad, igualdad

  1. La Reforma del Estado y la Social democracia

    Directory of Open Access Journals (Sweden)

    Manuel José Cárdenas

    2010-03-01

    Full Text Available En este artículo el autor sostiene que la gran tarea política de esta primera década del siglo XXI es la reconstrucción del Estado colombiano. Destaca que cuando existe una crisis Importante en el sistema político su origen debe buscarse en el Estado o en el mercado. La Depresión del año 30 se produjo por un mal funcionamiento del mercado y la Gran Crisis de los años 80 por el colapso del Estado. Esta crisis en realidad comprendió varias crisis: fiscal, el modelo de intervención del Estado en lo económico y en lo social y en la forma burocrática de la administración del Estado. Las reformas económicas orientadas al mercado fueron la respuesta a la necesidad de tener un Estado mínimo y de dar más libertad a las fuerzas del mercado. Con este propósito se expidió la Constitución Política de 1991 y se realizaron reformas en la mayoría de los campos económicos y sociales.  Ante el hecho de que estas reformas no han sido plenamente satisfactorias y que el Estado no ha podido recuperar su papel de agente del desarrollo, estando en la práctica paralizado, en su concepto no se requiere una nueva reforma constitucional salvo aspectos muy puntuales como las transferencias territoriales, la gran reforma que debe hacerse debe  ser de carácter administrativo para recuperar la gobernanza, aumentar la gobemab1hdad y fortalecer la capacidad de promoción del Estado. En el artículo se explican en detalle las acciones que deberían realizarse para llevar a la práctica ca a uno de estos tres conceptos. Todo ello para alcanzar un Estado social­ liberal, Social porque debe seguir protegiendo los derechos sociales y promoviendo el desarrollo económico. Liberal porque debe usar más los controles del mercado y menos los controles administrativos, para lo cual debe descentralizarse la acción estatal fortalecerse lo merca  s de trabajo con la capacitación de los recursos humanos fomentarse la 1nnovacwn, el conocimiento y la competitividad.

  2. A endogeneidade da crise fiscal do estado

    Directory of Open Access Journals (Sweden)

    Pichai Chumvichitra

    1985-11-01

    Full Text Available In the wake of the sharp and sudden petroleum price increase in 1973, Brazil opted to pursue a high rate of economic growth as a main strategy, managing the consequent strain on the balance of payments through a combination of renewad import substitution, export subsidies, and foreign borrowing However in order to reach this objective in the minimum period, there was an increase in the participation of the government activity to influence aggregate demand, besides its monetary and fiscal activities. The intervention of the government in the process of economic adjustment has been active for several years and continuously increases its role. Therefore, there was a big increase in a function of the public, acting through a large variety of subsidized credit programs, tax incentives, tariff preferences, etc., as well as its own direct investments, progressively substituted for the market as the principal allocator of investment in the economy. The consequence of this activity weakened the overall budgetary control of the central economic authorities and did not yield the desired results after 1980.Um dos fatores principais influenciando o problema de iliquidez na atual economia brasileira é a intervenção estatal na atividade econômica. Inicialmente a intervenção do Estado pode ser vista sob dois prismas: como regulador da economia com suas atividades de política econômica, e como empresário, quer participando diretamente como produtor e agente financeiro, quer participando indiretamente como implementador de programas setoriais da atividade econômica. Na aplicação de sua estratégia de crescimento, o setor público, agindo por meio de uma grande variedade de programas de crédito subsidiado, incentivos fiscais, preferências tarifárias, etc, e com seus próprios investimentos diretos, substituiu progressiva-mente o mercado como principal distribuidor do investimento na economia. A conseqüente proliferação e crescimento da institui

  3. Flebotomofauna al sureste del estado Lara, Venezuela

    Directory of Open Access Journals (Sweden)

    Luis Eduardo Traviezo

    2006-10-01

    Full Text Available Introducción. El reporte de 522 casos de leishmaniasis cutánea americana entre los años1988 al 2002 en el estado Lara (específicamente al sureste donde hubo un repunte, motivó elestudio de los vectores implicados en la transmisión. Objetivos. Determinar la abundancia, diversidad y distribución de flebótomos durante un añoen 11 poblaciones situadas entre los 600 y 1600 metros sobre el nivel del mar, relacionandosu abundancia con elementos climáticos. Materiales y métodos. Para las capturas se utilizaron trampas CDC (18:00 a 06:00 horascolocadas en zonas domésticas, peridomésticas y selváticas de casas donde hubo casos deleishmaniasis cutánea y se utilizó trampa Shannon en los alrededores de éstas, entre las19:30 y las 22:50 horas. Resultados. Se identificaron 10.326 ejemplares (8.867 hembras y 1.459 machos con unadiversidad de 11 especies, siendo Lutzomyia youngi (Feliciangeli & Murillo 1987, la másabundante con un 96,54%, seguida de Lutzomyia ovallesi (Ortiz, 1952 con 2,9%,caracterizándose L. youngi por tener predilección por los ambientes peridomésticos y seapreció mayor actividad desde las 19:30 a las 20:30 horas (Shannon. La población de LasMaticas (1360 msnm presentó la mayor abundancia, con un pico anual que coincidió con elfinal del verano, las primeras lluvias del invierno (régimen unimodal, la mayor temperaturamedia mensual del año (24°C y la menor humedad mensual del año (70%. Conclusión. Esta información permite conocer la población, ambiente y época del año dondese incremente la probabilidad de transmisión de la enfermedad, por la abundancia de lasespecies vectoras.

  4. Fazer cultura. Fazer(-se estado: vernissages e performatividade de estado em Córdoba

    Directory of Open Access Journals (Sweden)

    Gustavo Blázquez

    2012-04-01

    Full Text Available O artigo explora os processos de formação do Estado e as políticas culturais governamentais em Córdoba (Argentina durante a primeira década do século XXI. A partir da análise das cerimônias que marcam a inauguração de mostras de arte, ou vernissages, são discutidas as dimensões performativas das práticas estatais e descritas performances que, em nome da cultura, “fazem Estado” através de formas altamente estetizadas que apelam para a captação sensorial. Nessas performances, que envolvem os sujeitos a partir da estimulação poética de seus sentidos, o Estado se materializa duas vezes. A “magia do Estado” se faz quando acrescenta e estatiza as relações de interdependência entre diferentes agentes e quando materializa uma imagem atraente encarregada de reforçar a distinção como recurso para a produção de hegemonia.The present article explores processes of State formation and government cultural policies in Córdoba (Argentina during the first half of the 21st century. Analyzing the cerimonies that attend the inauguration of art exhibits - vernissages - we discuss the performative dimensions of State practices that, in the name of culture, “make the State” through highly esteticized forms which appeal to the senses. In these performances, the State is materialized in two ways. The “magic of the State” occurs when interdependent relationships between agents appears and is institutionalized and also when na attractive image materializes that destined to reinforce this distinction as a resource for the production of hegemony.

  5. Drug resistance to inhibitors of the human double minute-2 E3 ligase is mediated by point mutations of p53, but can be overcome with the p53 targeting agent RITA.

    Science.gov (United States)

    Jones, Richard J; Bjorklund, Chad C; Baladandayuthapani, Veerabhadran; Kuhn, Deborah J; Orlowski, Robert Z

    2012-10-01

    The human double minute (HDM)-2 E3 ubiquitin ligase plays a key role in p53 turnover and has been validated preclinically as a target in multiple myeloma (MM) and mantle cell lymphoma (MCL). HDM-2 inhibitors are entering clinical trials, and we therefore sought to understand potential mechanisms of resistance in lymphoid models. Wild-type p53 H929 MM and Granta-519 MCL cells resistant to MI-63 or Nutlin were generated by exposing them to increasing drug concentrations. MI-63-resistant H929 and Granta-519 cells were resistant to Nutlin, whereas Nutlin-resistant cells displayed cross-resistance to MI-63. These cells also showed cross-resistance to bortezomib, doxorubicin, cisplatin, and melphalan, but remained sensitive to the small molecule inhibitor RITA (reactivation of p53 and induction of tumor cell apoptosis). HDM-2 inhibitor-resistant cells harbored increased p53 levels, but neither genotoxic nor nongenotoxic approaches to activate p53 induced HDM-2 or p21. Resequencing revealed wild-type HDM-2, but mutations were found in the p53 DNA binding and dimerization domains. In resistant cells, RITA induced a G(2)-M arrest, upregulation of p53 targets HDM-2, PUMA, and NOXA, and PARP cleavage. Combination regimens with RITA and MI-63 resulted in enhanced cell death compared with RITA alone. These findings support the possibility that p53 mutation could be a primary mechanism of acquired resistance to HDM-2 inhibitors in MCL and MM. Furthermore, they suggest that simultaneous restoration of p53 function and HDM-2 inhibition is a rational strategy for clinical translation.

  6. A review of the incidence and coincidence of uterine and mammary tumors in Wistar and Sprague-Dawley rats based on the RITA database and the role of prolactin.

    Science.gov (United States)

    Harleman, Johannes H; Hargreaves, Adam; Andersson, Håkan; Kirk, Sarah

    2012-08-01

    Wistar rats are frequently selected for use in carcinogenicity studies because of their advantageous survival rate, which is more favorable than other strains such as the Sprague-Dawley (SD) strain. Uterine and mammary tumors are relatively common spontaneous neoplasms of both strains. We examined the incidence and coincidence of uterine tumors and mammary tumors in control animals of both strains within the RITA database. There was a strong inverse relationship between these tumor types in Wistar rats (p 10%.

  7. El estado laico: ¿importa su vigencia?

    Directory of Open Access Journals (Sweden)

    María del Luján Flores

    2014-07-01

    Full Text Available El objetivo del presente trabajo es el de reflexionar acerca del Estado Laico y de alguno de sus actuales desafios sin pretender dar respuestas sino más bien plantear interrogantes.La cuestión fundamental a nuestro entender es la de determinar si se entiende o no que el Estado Laico es el sistema adecuado a adoptarse en el mundo contemporáneo y en caso afirmativo qué implicancias tendría la violación de sus postulados.Contenido: El principio de laicidad y la libertad de pensamiento. El estado laico como garantía del desarrollo de los derechos humanos. La exigencia ética. Etica y derecho.Conclusiones

  8. Crime e castigo nos Estados Unidos: de Nixon a Clinton

    Directory of Open Access Journals (Sweden)

    Loïc Wacquant

    1999-11-01

    Full Text Available Este artigo analisa o crescimento exponencial do número de detentos ocorrido nos Estados Unidos a partir de meados dos anos 70. Procura mostrar que esse crescimento não corresponde a um aumento da criminalidade, mas à conjugação de três séries causais, quais sejam: o declínio do "ideal de reabilitação" dos prisioneiros, a instrumentalização do medo da violência pelos políticos e pela mídia e a função de mecanismo de controle racial assumido pelo sistema penal americano. Em suma, a hiperflação carcerária revela a contraface do enfraquecimento do Estado de Bem-Estar Social e a sua substituição por um Estado penal.

  9. Fenomenologia da depressão estado-limite

    Directory of Open Access Journals (Sweden)

    Kimura Bin

    Full Text Available Depois que o conceito de borderline ou de “estadolimite” foi constituído, seu emprego se generalizou rapidamente na psiquiatria contemporânea. Esse conceito está edificado inicialmente na fronteira entre as psicoses esquizofrênicas e as neuroses. Na psicanálise, a psicogênese do estado-limite foi principalmente formulada em termos de teoria de relação de objeto. Supõe-se que os doentes estado-limite fracassaram, na sua primeira infância, ao integrar suficientemente, nas relações, sua imagem do eu à imagem primordial do objeto materno. Neste trabalho, postulando a clivagem como o transtorno gerador, é fornecido um fundamento teórico para o parentesco – suposto primeiramente do ponto de vista puramente clínico – entre o estado-limite e a esquizofrenia.

  10. Suprema Corte de Justicia de los Estados Unidos

    Directory of Open Access Journals (Sweden)

    Suprema Corte de Justicia Estados Unidos de Norte América

    2015-10-01

    Full Text Available INFORME DEL INSTITUTO DE DERECHO INTERNACIONAL PUBLICO.AUTOS: ESTADOS UNIDOS (Apelante v./ HUMBERTO ALVAREZ MACHAINLOS HECHOS.Un ciudadano mejicano fue secuestrado por la fuerza (en su país y transportado en un avión particular a los E.E.U.U. donde fue arrestado bajo acusación de haber participado en el rapto y asesinato, cometidos en Méjico, de un agente del Departamento para el Control de la Droga de los Estados Unidos (D.E.A. y su acompañante. (... 

  11. El gasto militar del Estado costarricense, 1821-1870.

    Directory of Open Access Journals (Sweden)

    Esteban Corella Ovares

    2016-12-01

    Full Text Available El presente artículo examina la relación entre los gastos militares del Estado costarricense y la conformación de una Hacienda Pública, durante las primeras cinco décadas de vida independiente. Durante ese período se dio un crecimiento importante de las fuerzas militares, y en consecuencia de los recursos económicos asignados a éstas por parte de las autoridades. La construcción de los mecanismos para obtener, administrar y gastar  esos recursos económicos favoreció la consolidación del Estado moderno en Costa Rica.

  12. Estado Confusional Agudo nas Unidades de Cuidados Intensivos

    OpenAIRE

    Santos, L; Alcântara, J

    1996-01-01

    As alterações do comportamento frequentemente observadas em doentes internados nas unidades de cuidados intensivos (UCI), podem ser adequadamente designadas, na maioria das vezes, por estado confusional agudo, o qual se caracteriza por: flutuação do estado de vigília, distúrbio do ciclo vigília-sono, défice de atenção e concentração, desorganização do pensamento, manifestado entre outras formas por discurso incoerente, distúrbios da percepção sob a forma de ilusões e/ou alucinações, desorient...

  13. Investigación cualitativa: estado del arte

    OpenAIRE

    Reina Vanegas, Falon Carolina

    2014-01-01

    Las autoras producen y ponen en circulación un estado del arte sobre la investigación social cualitativa, con los objetivos específicos de: elaborar un marco conceptual sobre lo que es un estado del arte; exponer el proceso metodológico empleado para su construcción; establecer un marco histórico sobre la producción y circulación de material investigativo; describir las fuentes documentales consultadas, según su localización y posibles líneas de trabajo; y concluir acerca de los hallazgos de ...

  14. Clima do Estado de São Paulo

    Directory of Open Access Journals (Sweden)

    Marcello Martinelli

    2010-03-01

    Full Text Available Os fenômenos da atmosfera em contato com a superfície da Terra, portanto, de alto interesse para a sociedade humana, são estudados pela climatologia. Têm com fonte essencial a meteorologia.Ao abordar tais fenômenos trava-se contato com duas noções essenciais: a de tempo e de clima. São estados da atmosfera. Enquanto o tempo é uma combinação passageira, o clima resulta de condições que perduram por um período mais longo. Interessa, particularmente, o clima, por considerar estados mais duráveis...

  15. La migración México-Estados unidos

    OpenAIRE

    Santibañez Romellón, Jorge

    2014-01-01

    Note portant sur l'auteur TIJUANA: AVANT DE PASSER LA FRONTIÈRE EN BUS, DESTINATION LOS ANGELES(CLICHÉ: ANNICK TRÉGUER). INTRODUCCION La migracion de mexicanos hacia y desde los Estados Unidos es un proceso esencialmente social, económico, laboral y cultural que involucra a millones de mexicanos en México y en los Estados Unidos. El propósito de este breve documento es el de aportar una visión general de este importante proceso en lo que toca a la migración laboral, desde una perspectiva act...

  16. El Estado regulador en el Perú

    OpenAIRE

    Parodi Trece, Carlos

    1997-01-01

    Durante el gobierno de Alberto Fujimori se han dado cambios significativos en las instituciones del Estado. ¿Cuál es el sentido de todos estos cambios? ¿Reflejan fundamentalmente una estrategia de consolidación en el poder por parte de Alberto Fujimori? ¿Son más bien el resultado de la estrategia de las clases económicas dominantes para explotar mejor los recursos nacionales? o ¿son instituciones que reflejan un proceso de democratización del Estado? La contribución a la exploració...

  17. SOBRE O ESTADO DE NATUREZA E O ESTADO CIVIL: UM DIÁLOGO ENTRE THOMAS HOBBES E IMMANUEL KANT

    Directory of Open Access Journals (Sweden)

    Andreza Barreto Leitão

    2010-08-01

    Full Text Available No presente trabalho, busca-se trazer à luz as relações entre Estado, Sociedade Civil e garantias de liberdade tendo em vista a evolução do pensamento político a esse respeito. Para tanto, tomou-se como parâmetro a passagem do estado de natureza ao estado civil segundo as concepções de Thomas Hobbes e de Immanuel Kant, levando-se em consideração as influências e os respectivos contextos históricos em que os arcabouços teóricos de cada autor foram erigidos. O primeiro deles veria tal passagem como fruto de um cálculo interessado, o segundo, como resultado de um dever-ser.

  18. Apuntes sobre las instituciones y los programas de desarrollo rural en México. Del Estado benefactor al Estado neoliberal

    Directory of Open Access Journals (Sweden)

    Francisco Herrera Tapia

    2009-01-01

    Full Text Available El artículo realiza un análisis descriptivo de los programas de desarrollo rural en México en el marco de los dos grandes modelos políticoeconómicos: el Estado benefactor y el Estado neoliberal. El primero modelo caracterizado por una mayor intervención en la economía y en el desarrollo de las comunidades rurales, y el segundo, caracterizado por una menor presencia del Estado y una mayor participación de la iniciativa privada. Se enfatiza el nacimiento de la planeación en México y su mecánica de intervención en el medio rural, así como los principales contenidos teóricos, metodológicos y de gestión social de los programas de desarrollo concebidos para atender a la población rural.

  19. A REESTRUTURAÇÃO PRODUTIVA E O CIRCUITO INFERIOR DO TURISMO NAS PRAIAS DE REDINHA NOVA, SANTA RITA E JENIPABU, EXTREMOZ – RN

    Directory of Open Access Journals (Sweden)

    José Alexandre Berto de Almada

    2017-03-01

    Cette étude vise à analyser le processus de restructuration productive du tourisme à Rio Grande do Norte du territoire utilisée par le circuit inférieur du tourisme sur les plages appartenant à APAJ, Redinha Nova, Santa Rita et Jenipabu dans la municipalité de Extremoz, afin de comprendre la relation dialectique de l'interdépendance entre dépendante circuit inférieur du tourisme dans ces plages et le circuit supérieur fait du tourisme dans la Via Costeira et plage de Ponta Negra à Natal. L'analyse du circuit inférieur a été réalisée à partir du travail de terrain, effectué entre Janvier et Juin 2014 dans l’APAJ, qui a interviewé presque tous les commerçants locaux, à l'exception des dix entreprises ou des commerçants fermés qui ont refusé de participer à l'entrevue, totalisant quatre-vingt dix six établissements visités. Au cours du travail sur le terrain, nous avons également recueilli des données cartographiques via l'unité GPS dans laquelle ils ont été utilisés dans la préparation des cartes de répartition spatiale de l'urbanisation et territoire utilisés par le circuit inférieur dans l’APAJ. Lors de la visite de la ville de NatalLes touristes ne sont pas seulement dans cette ville. Il existe une variété de lieux à visiter, à la fois sur la côte nord et la côte sud de Rio Grande do Norte. L'un de ces lieux sont les plages de l’APAJ, Redinha Nova, Santa Rita et Jenipabu où le processus d'urbanisation dans la Via Costeira et Ponta Negra rendu possible la mise en place du circuit touristique inférieur cette apa. L'afflux de touristes à ces plages apporte avec elle un discours de développement économique pour le lieu et pour les habitants. La contradiction entre les deux circuits est plus mauvais pour ceux qui sont sur le côté inférieur de l'économie. Alors que les entreprises du circuit supérieur visent l'accumulation de capital ainsi que les dividendes peuvent être utilisés dans de nouveaux

  20. Estado actual de la programación del riego en limonero mediante medidas del estado hídrico

    OpenAIRE

    Moreno, F.; Ortuño, M.F.; García-Orellana, Y.; Alarcón, J.J.; Conejero, W.; Nicolás, E.; Fernández, J.E.; Martín-Palomo, M.J.; Torrecillas, A.

    2007-01-01

    En el presente trabajo se realiza una visión sobre aspectos relativos a la utilización de medidas continuas del estado hídrico del limonero en la programación del riego. Para ello, se analizó, la sensibilidad de distintos indicadores del estado hídrico medidos de forma continua o discontinua en las plantas, su significado fisiológico, la obtención de niveles de referencia de los indicadores y los primeros resultados sobre programación de riego. Peer Reviewed

  1. Medición del comercio intraindustrial Colombia - Estados Unidos 1995-2005

    OpenAIRE

    Caicedo Marulanda, Carolina

    2010-01-01

    Este documento analiza la existencia de comercio intraindustrial entre Colombia y Estados Unidos, usando la información contenida en la base de datos BACI del CEPII para el periodo comprendido entre 1995 y 2005. La pertinencia de establecer una medición de los flujos de comercio intraindustrial entre Colombia y Estados Unidos radica fundamentalmente en la importancia relativa que representa Estados Unidos como socio comercial para Colombia. El comercio bilateral entre Colombia y Estados c...

  2. O Estado cristão em Thomas Hobbes

    Directory of Open Access Journals (Sweden)

    Daniel Artur Emidio Branco

    2016-12-01

    Full Text Available O presente artigo tem como finalidade a investigação do pensamento do filósofo inglês Thomas Hobbes (1588-1679, mais precisamente a relação entre Igreja e Estado, valendo-se de suas obras, em especial Leviatã (1651. Com o título O Estado Eclesiástico em Thomas Hobbes, o artigo busca mostrar como as conclusões de Hobbes acerca do papel da Igreja no Estado são relevantes para o século XXI. A concepção de Evangelho de Cristo como um reino de outro mundo, a natureza privada da fé, o pontificado do soberano como aquele que se posiciona está entre Deus e os homens, a união entre Lei Mosaica e Lei Natural e a união entre Igreja e Estado são os delimitadores do grande tema, que busca levar o leitor contemporâneo ao conhecimento das conclusões de Hobbes e, assim, considerar a aplicação das mesmas a sua geração.

  3. O novo orçamento militar dos Estados Unidos

    Directory of Open Access Journals (Sweden)

    João Fábio Bertonha

    2011-09-01

    Full Text Available Tendo no atual orçamento militar dos Estados Unidos o ponto de partida, o presente artigo busca analisar o atual poderio militar daquele país, e os impactos deste no cenário internacional.

  4. Estado del conocimiento universal sobre el orden uredinales (fungi, royas.

    Directory of Open Access Journals (Sweden)

    Buriticá Céspedes Pablo

    2003-06-01

    Full Text Available Se presentan eventos naturales de ocurrencia en los Uredinales con una visión respecto al estado del conocimiento e interpretación universal, se hace énfasis en la importancia de profundizar en el saber que es necesario adquirir para comprender su “árbol de la vida”.

  5. ¿Libertad de prensa en los Estados Unidos?

    Directory of Open Access Journals (Sweden)

    Peter Schenkel

    2015-01-01

    Full Text Available Se pregunta el autor si Estados Unidos será la primera democracia del mundo? cuando en ese país los periodistas no tienen derecho de rehusarse a declarar como testigos frente a un jurado, donde bajo pretexto de seguridad se mantienen secretas las cosas de las cuales el público tiene derecho a enterarse.

  6. A vulnerabilidade dos Estados Unidos perante os novos inimigos

    Directory of Open Access Journals (Sweden)

    VIRGILIO ARRAES

    2011-09-01

    Full Text Available O presente artigo busca analisar os impactos que os recentes atentados terroristas de 11 de setembro de 2001 terão para os Estados Unidos enquanto grande líder mundial, além de delinear os possíveis rumos desse país na nova ordem mundial.

  7. Estado Actual de Ateles fusciceps fusciceps en el Noroccidente Ecuatoriano

    OpenAIRE

    Madden, R. H.; Albuja Viteri, Luis Humberto

    1989-01-01

    En este artículo se dan a conocer los resultados de los estudios sobre el estado actual de conservación del mono araña o bracilargo(Ateles f. fusciceps), que se realizó en el sector noroccidental del Ecuador, en el que se incluye una parte de la Reserva Ecológica Cotacachi, Cayapas.

  8. Ciudadania y Estado Del Bienestar: La Inmigracion Femenina en Espana

    Directory of Open Access Journals (Sweden)

    José Adelantado

    2011-06-01

    Full Text Available Normal 0 21 false false false PT-BR X-NONE X-NONE El Estado del Bienestar es un modelo institucional típico del desarrollo del estado-nación en Europa Occidental a lo largo del siglo XX. Es sucesor del Estado liberal decimonónico y se le atribuyen como finalidades propias conseguir la igualdad de oportunidades y la redistribución de recursos mediante un conjunto de políticas sociales. EI desarrollo del EB muestra la correspondencia entre la intensidad de los derechos y el tipo de asalarización de la fuerza de trabajo según clase, sexo y origen geográfico: sistemáticamente se observa que los hombres han disfrutado de más derechos que las mujeres y ambos que los y las inmigrantes. En ese contexto, el objeto de este trabajo consiste en averiguar la relación que vincula los derechos de ciudadanía con las desigualdades de clase-género-inmigración, relaci6n esta menos estudiada, sobre lodo en relación aI Estado deI Bienestar en Espanã.

  9. Ciudadania y Estado del Bienestar: La Inmigracion Femenina en Espana

    Directory of Open Access Journals (Sweden)

    José Adelantado

    2011-06-01

    Full Text Available Normal 0 21 false false false PT-BR X-NONE X-NONE El Estado del Bienestar es un modelo institucional típico del desarrollo del estado-nación en Europa Occidental a lo largo del siglo XX. Es sucesor del Estado liberal decimonónico y se le atribuyen como finalidades propias conseguir la igualdad de oportunidades y la redistribución de recursos mediante un conjunto de políticas sociales. EI desarrollo del EB muestra la correspondencia entre la intensidad de los derechos y el tipo de asalarización de la fuerza de trabajo según clase, sexo y origen geográfico: sistemáticamente se observa que los hombres han disfrutado de más derechos que las mujeres y ambos que los y las inmigrantes. En ese contexto, el objeto de este trabajo consiste en averiguar la relación que vincula los derechos de ciudadanía con las desigualdades de clase-género-inmigración, relación esta menos estudiada, sobre lodo en relación aI Estado deI Bienestar en Espanã.

  10. Faculty Activity Analysis in the Universidad Tecnica Del Estado Campuses.

    Science.gov (United States)

    Karadima, Oscar

    An analysis of academic activities of college faculty at the eight campuses of Chile's Universidad Tecnica del Estado was conducted. Activities were grouped into seven categories: direct teaching, indirect teaching, research, community services, faculty development, academic administration, and other activities. Following the narrative…

  11. Formation of processes erosion associated with the use and occupation of soil in the Ribeira river basin, city of Santa Rita / PB | Formação de erosão de processos associada ao uso e ocupação do solo na bacia do rio Ribeira, cidade de Santa Rita / PB

    Directory of Open Access Journals (Sweden)

    Caio Lima dos Santos

    2016-06-01

    Full Text Available The way the man has appropriated natural resources, has been revealed as the source of many problems in the environment, which has been reflected directly in the depletion of natural resources and quality of life. The erosion and loss of soil are part of these degenerative processes of the natural landscape. The watershed of the river Ribeira, located in Santa Rita, Paraíba State, is a current example of such processes that are directly associated with forms of land use. Actions arising mainly from the extensive cultivation of cane sugar has been revealed through the development of geomorphological processes that mark the landscape through erosional features, such as small fillets, grooves, and gully, plus a large amount of alluvial fans that protrude over the lowlands often silted water bodies.

  12. INFLUÊNCIA DA QUALIDADE DA ÁGUA DESTINADA AO CONSUMO HUMANO NO ESTADO NUTRICIONAL DE CRIANÇAS COM IDADES ENTRE 3 E 6 ANOS, NO MUNICÍPIO DE OURO PRETO-MG

    Directory of Open Access Journals (Sweden)

    A. C. ANTUNES

    2008-09-01

    Full Text Available

    A água corresponde a 70% do peso corporal. Excelente solvente, ela pode veicular produtos químicos, germes e parasitas, representando risco potencial à saúde da população, se não apresentar características de potabilidade dentro dos padrões legais. Como o distrito de Santa Rita de Ouro Preto não possui sistema de abastecimento convencional, neste trabalho buscou-se avaliar a qualidade da água desse sistema e verificar sua influência no estado nutricional de crianças de 03 a 06 anos. Foram coletadas 381 amostras de água, no período de julho de 2003 a abril de 2004, em residências, nascentes e reservatórios. Essas amostras foram submetidas às análises físico-químicas e bacteriológicas. Nas crianças moradoras das casas amostradas, foram realizados exame parasitológico de fezes e avaliação do estado nutricional. A água não se apresentou potável. Em 43% das amostras foram encontradas bactérias coliformes termotolerantes, em 100% cloro residual negativo, além de turbidez fora dos padrões em 55 amostras. Parasitas de veiculação hídrica foram encontrados nas amostras de fezes: Giardia lamblia (7,1%, Ascaris lumbricoides (33,3% e Entamoeba coli (46,4%. O estado nutricional das crianças foi considerado satisfatório, mas a qualidade da água pode reverter o quadro, se mecanismos que proporcionem melhorias da potabilidade não forem previstos.

  13. Estado social de derecho o estado de opinión: dilema sin resolver en América Latina

    Directory of Open Access Journals (Sweden)

    Orlando José Cadrazco Salcedo

    2010-01-01

    Full Text Available Resumen:El alcance del Estado Social de Derecho no se circunscribe solamente a su terminología ni a lo etimológico desu traducción, todo por el contrario se da en las relaciones que deben marcar el comportamiento del Estado frentea los conciudadanos que lo integran y se refuerza con el principio de la Dignidad Humana, lo que había venidosiendo tratado desde la Revolución Francesa pero que ahora cobra mayor vigencia, dada la alta concentracióndel garantismo que sobre los derechos de los individuos deben preservar los Estados frente al conglomeradosocial. En el Estado de Opinión si bien existen unas normas, estas se van acomodando diariamente según elquerer del Gobernante de turno y lo que prima no es el apego o cumplimiento de las normas, sino la manipulaciónque el o los Gobernantes de turno hacen de la opinión pública a través de los medios masivos de comunicacióny el manejo de las encuestas de opinión que sirven para catapultar o enterrar un gobernante o un período deGobierno en un estado determinado.Palabras Claves:Estado Social de Derecho, Estado de Opinión, Gobierno, Democracia, Constitución, Población, Encuestas,Medios de Comunicación, Derechos Sociales.Abstract:The scope of the rule of law is not limited to terminology or the etymology of its translation, on the contrary,everything is in relationships that should mark the conduct of the State against the citizens in it and is strengthenedby the principles of human dignity, which had been treated since the French Revolution, but now becomes moreeffective, given the high concentration of the guarantors of the rights of individuals to preserve the front of thesocial conglomerate. In the state of opinion, although there are rules, they will want to accommodate the daily asthe ruler of the day and what the attachment is no premium or compliance, but the handling or the rulers of themake-shift public opinion through the mass media and the handling of the polls used to bury a

  14. New Orleans before and after Hurricanes Katrina/Rita: a quasi-experiment of the association between soil lead and children's blood lead.

    Science.gov (United States)

    Zahran, Sammy; Mielke, Howard W; Gonzales, Christopher R; Powell, Eric T; Weiler, Stephan

    2010-06-15

    Prior to Hurricanes Katrina and Rita (HKR), significant associations were noted between soil lead (SL) and blood lead (BL) in New Orleans. Engineering failure of New Orleans levees and canal walls after HKR set the stage for a quasi-experiment to evaluate BL responses by 13 306 children to reductions in SL. High density soil surveying conducted in 46 census tracts before HKR was repeated after the flood. Paired t test results show that SL decreased from 328.54 to 203.33 mg/kg post-HKR (t = 3.296, p or =50% decrease in SL. Also individual BL in children was predicted as a function of SL, adjusting for age, year of observation, and depth of flood waters. At the individual scale, BL decreased significantly in post-HKR as a function of SL, with BL decreases ranging from b = -1.20 to -1.65 microg/dL, depending on the decline of SL and whether children were born in the post-HKR period. Our results support policy to improve soil conditions for children.

  15. Florística em um hectare de cerrado stricto sensu na ARIE - cerrado Pé-de-Gigante, Santa Rita do Passa Quatro, SP

    Directory of Open Access Journals (Sweden)

    Weiser Veridiana de Lara

    2001-01-01

    Full Text Available Foi realizado um levantamento florístico em um ha de cerrado stricto sensu, na parte norte da ARIE - Cerrado Pé-de-Gigante, Santa Rita do Passa Quatro, São Paulo. Foram coletados 428 espécimes em fase reprodutiva, em vinte e cinco excursões de coleta, durante o período de novembro de 1996 a abril de 1998. A listagem florística obtida apresenta 141 espécies, distribuídas em 109 gêneros e 49 famílias. As famílias mais representativas foram: Leguminosae, Asteraceae, Malpighiaceae e Myrtaceae. A floração e frutificação das espécies foram maiores no período chuvoso. Espécies zoocóricas (61 predominaram, seguidas pelas anemocóricas (46 e autocóricas (34. Analisou-se a flora como um todo e seus componentes herbáceo-subarbustivo e arbustivo-arbóreo, separadamente.

  16. Riems influenza a typing array (RITA): An RT-qPCR-based low density array for subtyping avian and mammalian influenza a viruses.

    Science.gov (United States)

    Hoffmann, Bernd; Hoffmann, Donata; Henritzi, Dinah; Beer, Martin; Harder, Timm C

    2016-06-03

    Rapid and sensitive diagnostic approaches are of the utmost importance for the detection of humans and animals infected by specific influenza virus subtype(s). Cascade-like diagnostics starting with the use of pan-influenza assays and subsequent subtyping devices are normally used. Here, we demonstrated a novel low density array combining 32 TaqMan(®) real-time RT-PCR systems in parallel for the specific detection of the haemagglutinin (HA) and neuraminidase (NA) subtypes of avian and porcine hosts. The sensitivity of the newly developed system was compared with that of the pan-influenza assay, and the specificity of all RT-qPCRs was examined using a broad panel of 404 different influenza A virus isolates representing 45 different subtypes. Furthermore, we analysed the performance of the RT-qPCR assays with diagnostic samples obtained from wild birds and swine. Due to the open format of the array, adaptations to detect newly emerging influenza A virus strains can easily be integrated. The RITA array represents a competitive, fast and sensitive subtyping tool that requires neither new machinery nor additional training of staff in a lab where RT-qPCR is already established.

  17. O PAPEL DO ESTADO E O “WELFARE MIX”

    Directory of Open Access Journals (Sweden)

    Vera Maria Ribeiro Nogueira

    2005-01-01

    Full Text Available Este trabalho analisa os atuais papéis assumidos pelo Estado e pela sociedade no mundo capitalista ocidental. Entende o projeto societário liberal como excludente e desigual, produzindo, reproduzindo e ampliando a questão social e determinando as distintas formas de intervenção estatal. A partir das últimas décadas, o processo de ajuste estrutural das economias nacionais vem reconfigurando a atuação estatal tendo por base a política de Estado Mínimo e o surgimento de um novo esquema de proteção social denominado de “Welfare Mix”, que incentiva a introdução das organizações empresariais e do Terceiro Setor na área das políticas sociais.

  18. MUNDIALIZACIÓN IMPERIALISTA: Estados nacionales y soberania

    Directory of Open Access Journals (Sweden)

    Isabel Monal

    2005-01-01

    Full Text Available La globaiización como un proceso histórico real. La presente etapa de la globalización está intimamente relacionada con la nueva fase del imperialismo. Por lo tanto, para cumprender la globalización tiene que ser vista dentro del marco del imperialismo contemporáneo. Contrariamente a ciertas creencias, la política no queda rezagada en relación con ia economia, ni tampoco ei Estado nacional se ha hecho marginal con ei presente proceso de la giobalización capitalista. Algunas de sus prerrogativas tradicionales han quedado disminuidas, peru nuevas funciones surgen y otras son incrementadas; una de estas últimas es que la globalización necesita la acción del Estado para su realización.

  19. A cosmologia do estado quase-estacionário

    Directory of Open Access Journals (Sweden)

    Jayant V. Narlikar

    2000-05-01

    Full Text Available Discutem-se em primeiro lugar as falhas na cosmologia oficial, seguido por uma breve descrição da cosmologia alternativa chamada Cosmologia do Estado Quase Constante. Descrevem-se também o arcabouço teórico e os testes referentes a CEQC. Por último, são mencionados os testes que testemunham a distinção entre a cosmologia oficial do Big Bang e a CEQC

  20. Nuevas políticas sociales y Estado social relacional.

    Directory of Open Access Journals (Sweden)

    PIERPAOLO DONATI

    2004-01-01

    Full Text Available Según el autor, las sociedades europeas siguen inspirando las políticas sociales en un código (estatal de inclusión ?al que aquí se denomina lib/lab (mezcla de liberalismo y laborismo? que en el pasado ha constituido un factor de progreso, pero que actualmente resulta cada vez más débil y obsoleto. Las políticas sociales encuentran límites estructurales en sus posibilidades de innovación porque están formuladas como compromisos entre Estado y mercado, utilizando al sector terciario para remediar los fracasos de los otros dos sectores. De hecho, los sistemas sociales gobernados por lógicas lib/lab se encaminan a una crisis irreversible. El documento ilustra las nuevas tendencias de configuración de las políticas sociales, que aquí se denominan "societarias ". Se caracterizan por dos novedades principales: primero, por el hecho de que confían la inclusión social a una ciudadanía compleja (concebida como entrelazamiento de ciudadanía estatal y ciudadanía societaria, en la cual poseen un papel primordial los sujetos colectivos de la sociedad civil; segundo, porque definen el Bienestar, los servicios y los derechos sociales mediante un código simbólico de tipo relacional. En términos de orden institucional, se trata de pasar a un "cuarto modelo de Estado del Bienestar", es decir, a un Estado social de cuarta generación, después de haber dejado atrás el paternalista, el asistencial y el intervencionista. El autor lo denomina Estado social relacional.

  1. Estados del Bienestar y globalización

    Directory of Open Access Journals (Sweden)

    Marta Graciela Cabeza

    2009-12-01

    Full Text Available La dificultad con la que nos encontramos cuando queremos definir Estado de Bienestar es considerable, ya que es un concepto muy generalizado que se utiliza para indicar varias acciones o actitudes del Estado, entre ellas la intención de redistribución del ingreso para ayudar a los más pobres. Es por ello que en este ensayo intentaremos reflexionar sobre el concepto mismo de Estado de Bienestar para poder abordar luego su evolución y su actual crisis. También el concepto de globalización comparte las características citadas previamente ya que se usa para denominar demasiadas cosas, pero aquí lo entendemos como interconexiones económicas, sociales, culturales y políticas, las redes conformadas por todo este entramado de fenómenos sociales y los procesos que muchas veces trascienden las fronteras nacionales. El propósito es relacionar estas interconexiones y procesos con la crisis del Estado de Bienestar y su posible transformación.___________________ABSTRACT:Difficulty when we want to define Welfare State is considerable, because is a concept very generalized that is used to indicate several actions or attitudes of the State, among them the redistribution intention to help poorest. It is for that reason that in this test we will try to reflect on the same concept of Welfare State to be able to soon approach its evolution and its present crisis. Also the globalization concept shares the characteristics mentioned since it is used to denominate too many things, but we understand it here like economic, social, cultural and political interconnections, the networks conformed by all this built the framework for of social phenomena and the processes that often extend the national borders. The intention is to relate these interconnections and processes to the crisis of the Welfare State  and their possible transformation.

  2. Importancia de la proporcionalidad en nadadores federados del estado Miranda

    OpenAIRE

    Ortega de Mancera, Alicia; Ledezma, Thaís

    2005-01-01

    La natación es un deporte con grandes y continuas exigencias físicas durante el entrenamiento, clave para el éxito deportivo. Sin embargo algunos autores plantean la existencia de rasgos de proporcionalidad que en cierta forma caracterizan a los nadadores elite e influyen en una mejor "performance". El objetivo es analizar las proporciones consideradas propias de los nadadores elite y establecer si las mismas caracterizan a los nadadores del Estado Miranda. Se evaluaron 183 deportistas, 67 ni...

  3. Paleoenvironmental and paleoclimatic investigations on Isla de los Estados, Argentina

    Science.gov (United States)

    Björck, S.; Fernandez, M.; Hjort, C.; Ljung, K.; Martinez, O.; Möller, P.; Ponce, F.; Rabassa, J.; Roig, F.; Unkel, I.; Wohlfarth, B.

    2007-05-01

    The expedition in November-December 2005 to Isla de los Estados (Staten Island) off the southeastern tip of South America was a cooperative venture between Lund University (LU) and Stockholm University (SU) in Sweden and the CADIC-CONICET Institute in Ushuaia, Argentina. The aim of the expedition was threefold: (1) to extend the Swedish paleoclimatic "ATLANTIS"-project (Greenland, Iceland, Faroe Islands, Azores, Grenada, Tristan da Cunha; PI S Björck) to the southern part of the South American continent, (2) to connect earlier glacial and climate history reconstructions from the Antarctic Peninsula to equivalents north of the Drake Passage in southernmost South America, and (3) to complement paleo-information available from the Tierra del Fuego mainland with information from Isla de los Estados. Focus was on two areas in the northern and north-western part of the island, Bahía Colnett and Bahia Crossley. Detailed geomorphologic and stratigraphic mapping of glacial deposits were combined with sampling sediments for OSL dating. To reconstruct the paleoclimatic development of Isla de los Estados since the last ice retreat, four main peat bog/lake sites were cored and sampled. In addition, living trees of Nothofagus and old logs preserved in the peat were sampled for dendrochronological and dendroclimatological studies. Preliminary results show that the deglaciation of the study area occurred before 16500 cal yr BP. Detailed multi- proxy analyses of the four sequences are under way and first results will be presented.

  4. El Estado Islámico: Catalizador del irredentismo kurdo.

    Directory of Open Access Journals (Sweden)

    David Ernesto Garzón García

    2017-01-01

    Full Text Available Con su aparición, el Estado Islámico se consolida como una amenaza de carácter internacional y se convierte en el elemento pivote de la reestructuración de las relaciones internacionales, la configuración de nuevas alianzas y ciertamente en el impulsor de escenarios anteriormente poco presumibles con relación al Medio Oriente, entre ellos se establece como uno de los componentes catalizadores del irredentismo kurdo y su proyecto estatal e independentista. La reaparición de los kurdos en la esfera internacional potenciada por el estado Islámico, al ser en un principio el único grupo con capacidad de enfrentarlos, genera tensiones en la región pues la consolidación del Kurdistán alteraría la estructura territorial de cuatro Estados particularmente y sus relaciones políticas y comerciales, impactando directamente en la relativa estabilidad que ha imperado en el siglo XXI.

  5. Estado epiléptico, consideraciones sobre manejo y tratamiento

    Directory of Open Access Journals (Sweden)

    Solari B. Francesca, Dra.

    2013-11-01

    Full Text Available El estado epiléptico es una emergencia médica. Existen diversas definiciones de estado epiléptico y clasificaciones según etiología, tipo de crisis y respuesta a terapia. En esta revisión, se adopta la variable tiempo como fundamental en el manejo del paciente. Otro concepto que se resalta, es la sospecha frente a pacientes graves o con ciertas patologías, la posibilidad de presentar estado epiléptico no convulsivo, ya que la identificación de este, podría mejorar el manejo del paciente grave. Las benzodiacepinas siguen siendo la terapia de primera línea, con una muy buena tasa de respuesta, cuanto más precoz se adopte la terapia. Se discuten diferentes terapias de segunda línea (fenitoína, fenobarbital, valproato, levetiracetam y midazolam y se mencionan aquellas de tercera línea, tanto farmacológicas como otras (dieta cetogénica, inmunosupresores, corticoides y cirugía.

  6. De los Estados fallidos a los Estados frágiles: un reto para el Derecho internacional contemporáneo [RECENSIÓN

    OpenAIRE

    Ortiz-Hernández, E. (Eimys)

    2013-01-01

    Recensión de Garciandía Garmendia, R., De los Estados fallidos a los Estados frágiles: un reto para el Derecho internacional contemporáneo Ed. Comares, Granada, 2013, 294 pp. (ISBN: 978-84-9045-054-3)

  7. Superfund oversight. Hearing before the Committee on Environment and Public Works, United States Senate, Ninety-Eighth Congress, First Session to receive testimony from Rita M. Lavelle, February 23, 1983. Part 1

    Energy Technology Data Exchange (ETDEWEB)

    1983-01-01

    Part 1 of the hearing record covers the testimony of Rita M. Lavelle, former Assistant Administrator for Solid Waste and Emergency Response of the Environmental Protection Agency (EPA). Lavelle was asked to respond to charges against her performance and to describe how policy decisions are made at the agency. At issue were criticisms that EPA administrators were obstructing the implementation of environmental laws. Lavelle accused critics of undermining the agency's effectiveness and credibility in their handling of her departure from EPA, and responded to questions on her relationships with agency personnel. (DCK)

  8. OS ARQUITETOS DA INDEPENDÊNCIA: O CONSELHO DE ESTADO E A CONSTRUÇÃO DE UM ESTADO NACIONAL BRASILEIRO (1822-1834

    Directory of Open Access Journals (Sweden)

    Walter Guandalini Jr.

    2014-01-01

    Full Text Available El artículo pretende comprender la actuación del Consejo de Estado en la construcción de un Estado nacional brasilero, desde su formación como Consejo General de Procuradores Generales de las Provincias del Brasil (1822-1823, pasando por su consolidación constitucional como Consejo de Estado (1823-1831, hasta su decadencia y extinción en el inicio de la Regencia (1831-1834. La investigación desea contribuir a la solución de la cuestión referente al papel desempeñado por el Consejo de Estado en el Brasil: al contrario de lo que afirma la doctrina brasilera del derecho administrativo, la institución no cumple funciones jurídicas, limitándose al trabajo de constitución de una estructura política para el nuevo Estado naciente.

  9. Toxic trace element assessment for soils/sediments deposited during Hurricanes Katrina and Rita from southern Louisiana, USA: a sequential extraction analysis.

    Science.gov (United States)

    Shi, Honglan; Witt, Emitt C; Shu, Shi; Su, Tingzhi; Wang, Jianmin; Adams, Craig

    2010-07-01

    Analysis of soil/sediment samples collected in the southern Louisiana, USA, region three weeks after Hurricanes Katrina and Rita passed was performed using sequential extraction procedures to determine the origin, mode of occurrence, biological availability, mobilization, and transport of trace elements in the environment. Five fractions: exchangeable, bound to carbonates, bound to iron (Fe)-manganese (Mn) oxides, bound to organic matter, and residual, were subsequently extracted. The toxic trace elements Pb, As, V, Cr, Cu, and Cd were analyzed in each fraction, together with Fe in 51 soil/sediment samples. Results indicated that Pb and As were at relatively high concentrations in many of the soil/sediment samples. Because the forms in which Pb and As are present tend to be highly mobile under naturally occurring environmental conditions, these two compounds pose an increased health concern.Vanadium and Cr were mostly associated with the crystal line nonmobile residual fraction. A large portion of the Cu was associated with organic matter and residual fraction. Cadmium concentrations were low in all soil/sediment samples analyzed and most of this element tended to be associated with the mobile fractions. An average of 21% of the Fe was found in the Fe-Mn oxide fraction, indicating that a substantial part of the Fe was in an oxidized form. The significance of the overall finding of the present study indicated that the high concentrations and high availabilities of the potentially toxic trace elements As and Pb may impact the environment and human health in southern Louisiana and, in particular, the New Orleans area. Copyright (c) 2010 SETAC.

  10. Calidad microbiológica y parasitológica de lechuga (Lactuca sativa y cilantro (Coriandrum sativum expendidos en la Parroquia Santa Rita, Aragua, Venezuela

    Directory of Open Access Journals (Sweden)

    Nirza Noguera Machado

    2016-10-01

    Full Text Available Las hortalizas aportan grandes beneficios para la salud debido a sus innumerables propiedades alimenticias; sin embargo, existe una gran variedad de factores que ponen en riesgo la calidad sanitaria de las mismas constituyéndose en vehículos para enfermedades de transmisión alimentaria (ETA. Por ello, se decidió evaluar la calidad microbiológica y parasitológica de dos hortalizas, lechuga (Lactuca sativa y cilantro (Coriandrum sativum expendidas en la Parroquia Santa Rita del Municipio Francisco Linares Alcántara (Aragua, Venezuela. Se analizaron un total de 20 muestras, 10 de cilantro y 10 de lechuga; la determinación microbiológica se realizó por la técnica del Número Más Probable y el análisis parasitológico, mediante observación directa, tinción de Kinyoun y la técnica de Faust. Los resultados mostraron la presencia de coliformes totales (1,1x104 NMP/g en el 100 % de las muestras. No se evidenció coliformes fecales en ninguna de las muestras. En relación al análisis parasitológico, se identificaron protozoarios intestinales, con mayor prevalencia de Blastocystis spp. y menor en helmintos. Los resultados demuestran el peligro potencial que representa el consumo de hortalizas frescas contaminadas para la salud pública. Se debe concientizar a la población sobre medidas sanitarias preventivas que deben aplicar antes del consumo e implementar medidas de control que mejoren las condiciones higiénicas en la cadena de comercialización.

  11. Looking for the Silver Lining: Benefit Finding after Hurricanes Katrina and Rita in Middle-Aged, Older, and Oldest-Old Adults.

    Science.gov (United States)

    Stanko, Katie E; Cherry, Katie E; Ryker, Kyle S; Mughal, Farra; Marks, Loren D; Brown, Jennifer Silva; Gendusa, Patricia F; Sullivan, Marisa C; Bruner, John; Welsh, David A; Su, L Joseph; Jazwinski, S Michal

    2015-09-01

    Looking for potentially positive outcomes is one way that people cope with stressful events. In two studies, we examined perceived "silver linings" after the 2005 Hurricanes Katrina and Rita among indirectly affected adults. In Study 1, middle-aged (ages 47-64 years), older (ages 65-89 years), and oldest-old (ages 90-95 years) adults in the Louisiana Healthy Aging Study (LHAS) responded to an open-ended question on perceived silver linings in a longitudinal assessment carried out during the immediate impact (1 to 4 months after landfall) and post-disaster recovery phase (6 to 14 months post-storm). Qualitative grounded theory methods were employed to analyze these narrative data. Team-based coding yielded three core themes: (1) learning experience and better preparedness for future disasters, (2) having improved cities (Baton Rouge and New Orleans), and (3) an increase in "Good Samaritan" acts such as strangers helping one another. Responses were similar across age groups, although older adults were the least likely to report positive outcomes. Study 2 was a conceptual replication using a different sample of adults (ages 31 to 82 years) tested at least five years after the storms. A learning experience and preparedness core theme replicated Study 1's findings while improved social cohesion amongst family and friends emerged as a new core theme in Study 2. These data indicate that identifying lessons learned and potentially positive outcomes are psychological reactions that may facilitate post-disaster coping and foster resilience for indirectly affected adults in the years after disaster.

  12. Relativistically Induced Transparency Acceleration (RITA) - laser-plasma accelerated quasi-monoenergetic GeV ion-beams with existing lasers?

    Science.gov (United States)

    Sahai, Aakash A.

    2013-10-01

    Laser-plasma ion accelerators have the potential to produce beams with unprecedented characteristics of ultra-short bunch lengths (100s of fs) and high bunch-charge (1010 particles) over acceleration length of about 100 microns. However, creating and controlling mono-energetic bunches while accelerating to high-energies has been a challenge. If high-energy mono-energetic beams can be demonstrated with minimal post-processing, laser (ω0)-plasma (ωpe) ion accelerators may be used in a wide-range of applications such as cancer hadron-therapy, medical isotope production, neutron generation, radiography and high-energy density science. Here we demonstrate using analysis and simulations that using relativistic intensity laser-pulses and heavy-ion (Mi ×me) targets doped with a proton (or light-ion) species (mp ×me) of trace density (at least an order of magnitude below the cold critical density) we can scale up the energy of quasi-mono-energetically accelerated proton (or light-ion) beams while controlling their energy, charge and energy spectrum. This is achieved by controlling the laser propagation into an overdense (ω0 RITA). Desired proton or light-ion energies can be achieved by controlling the velocity of the snowplow, which is shown to scale inversely with the rise-time of the laser (higher energies for shorter pulses) and directly with the scale-length of the plasma density gradient. Similar acceleration can be produced by controlling the increase of the laser frequency (Chirp Induced Transparency Acceleration, ChITA). Work supported by the National Science Foundation under NSF- PHY-0936278. Also, NSF-PHY-0936266 and NSF-PHY-0903039; the US Department of Energy under DEFC02-07ER41500, DE- FG02-92ER40727 and DE-FG52-09NA29552.

  13. Florística de lianas em um fragmento de floresta estacional semidecidual, Parque Estadual de Vassununga, Santa Rita do Passa Quatro, SP, Brasil Floristic of lianas in a fragment of seasonal semidecidual forest State Park of Vassununga, Santa Rita do Passa Quatro, São Paulo State, Brazil

    Directory of Open Access Journals (Sweden)

    Yara Junqueira de Azevedo Tibiriçá

    2006-06-01

    Full Text Available Embora o conhecimento sobre a florística dos fragmentos de florestas estacionais semideciduais tenha crescido nos últimos anos, ainda sabe-se pouco sobre a comunidade de lianas (lenhosas ou herbáceas nesses fragmentos. Assim, foi realizado o levantamento florístico de lianas na gleba Maravilha, pertencente ao Parque Estadual de Vassununga (Santa Rita do Passa Quatro, SP, a fim de colaborar com o conhecimento dessa comunidade e subsidiar futuros trabalhos que envolvam essa forma de vida. A área de estudo compreende 127,08 ha, com inverno seco e temperatura média anual de 22 ºC. Para a coleta do material, percorreu-se mensalmente toda a borda do fragmento e três trilhas no interior da mata, de agosto/2002 a setembro/2003. Foram identificadas 120 espécies de lianas, pertencentes a 30 famílias e 71 gêneros, das quais 51% das espécies são volúveis, 42% apresentam gavinhas e apenas 7% são escandentes. As famílias mais representativas em número de espécies foram: Bignoniaceae (26, Malpighiaceae (14, Sapindaceae (12 e Asteraceae (9. Houve baixa similaridade florística entre as espécies de lianas presentes na gleba Maravilha em relação a outras áreas de florestas estacionais semideciduais do interior paulista.Although the knowledge about the floristic composition of the fragments of seasonal semidecidual forest had grown in the last few years, little is known about the liana communities (woody vines and herbaceous vines in those fragments. To collaborate with the knowledgement of the lianas and subsidize future works involving this life form, a floristic survey of the liana species occurring at the fragment Maravilha of the State Park of Vassununga (Santa Rita do Passa Quatro - SP was carried out. The study area comprised 127.08ha, with average temperature of 22 ºC. The whole border of the forest fragment and three tracks inside the forest were surveyed monthly between August 2002 and September 2003. One hundred and twenty species

  14. La responsabilidad patrimonial del Estado legislador en el ámbito tributario

    OpenAIRE

    Pérez Bernabeu, Begoña

    2016-01-01

    La responsabilidad patrimonial del Estado es un instituto básico en un Estado de Derecho, extendiéndose a los tres poderes del Estado: Legislativo, ejecutivo y judicial. En la actualidad existe un elevado grado de consenso en nuestro país al afirmar que el reconocimiento constitucional de la responsabilidad patrimonial del Estado legislador reside en el apartado 3 del artículo 9 de nuestra Constitución. En el ámbito tributario este instituto reviste una especial importancia habida cuenta de l...

  15. Responsabilidad de directores de sociedades en Estados Unidos. Aspectos procesales

    Directory of Open Access Journals (Sweden)

    Héctor José Miguens

    2015-01-01

    El objeto de este artículo es describir este régimen en su totalidad y realizar un juicio crítico de las normas que rigen las acciones procesales de la responsabilidad de los directores de sociedades comerciales en el derecho societario en Estados Unidos. La metodología utilizada en este trabajo responde a la sistemática de los autores norteamericanos citados, que se caracteriza por centrarse en los aspectos prácticos, la solución de problemas particulares y el comentario crítico de la jurisprudencia aplicable a la cuestión.

  16. La Seguridad ciudadana como función del Estado

    OpenAIRE

    Ridaura Martínez, María Josefa

    2014-01-01

    Este trabajo se centra en uno de los temas medulares de la organización del Estado como es la garantía de la seguridad, y tiene como objeto reivindicar, al calor la reciente sacudida legislativa en materia, la función de la Seguridad ciudadana como una función pública a desarrollar por las Fuerzas y Cuerpos de Seguridad; en tanto que exigencia constitucional, presupuesto de la salvaguarda de los derechos fundamentales y de las libertades públicas.

  17. Vigilancia epidemiológica del estado de salud bucal

    OpenAIRE

    . Amado Rodríguez Calzadilla; . Carolina Valiente Zaldívar

    1999-01-01

    Se exponen aspectos relacionados con la vigilancia epidemiológica del estado de salud bucal de la población general, con fines metodológicos. Se plantean los objetivos y las premisas para establecer el sistema de vigilancia, así como la caracterización de la comunidad basados en los elementos fundamentales para un sistema de vigilancia. Se pretende evaluar costo y calidad de la atención de la salud bucal para lograr el aprovechamiento eficiente de los recursos. Se realizarán investigaciones r...

  18. El balance social y los estados financieros prospectivos

    OpenAIRE

    Viegas, Juan Carlos; Instituto de Investigaciones en Administración, Contabilidad y Métodos Cuantitativos para la Gestión

    2012-01-01

    Balance Social es un instrumento de gestión para planear, organizar, dirigir, registrar, controlar y evaluar en términos cuantitativos o cualitativos la gestión social de una empresa, en un periodo determinado y frente a unas metas preestablecidas. alta calidad en materia de contabilidad y revelación de información financiera y no financiera. Cabe destacar, la importancia que reviste para estos nuevos informes de sustentabilidad la presentación de los estados financieros prospectivos. El Esta...

  19. Un sistema internacional inestable con dominio de los Estados Unidos

    Directory of Open Access Journals (Sweden)

    Pierre Gilhodes

    2004-11-01

    Full Text Available Con la imposición de la agenda única de terrorismo y la invasión a Iraq ¿se consolidó Estados Unidos como potencia mundial? o con el ascenso de China y los avances constitucionales europeos podríamos avanzar hacia una nueva división del mundo sobre bases diferentes de las de la Guerra Fría. En este caso ¿dónde se situaría AméricaLatina?

  20. El desmantelamiento del Estado multicultural en el Ecuador

    OpenAIRE

    Martínez Novo, Carmen

    2016-01-01

    La educación bilingüe intercultural asociada a la gestión del movimiento indígena ha sido progresivamente desmantelada por el gobierno de Correa. La definición de Estado multicultural y plurinacional que maneja el gobierno se encuentra en oposición a la que postuló el movimiento indígena. Las prácticas homogeneizantes de reforma del sistema escolar evidencian una modernización autoritaria que implanta un simulacro de multiculturalidad con el predominio de concepciones asimilacionistas.

  1. Limitaciones del IMC como indicador exclusivo de estado nutricional

    OpenAIRE

    Moreno Romero, Susana; Dipierri, José Edgardo; Marrodán, María D.

    2007-01-01

    El presente trabajo tiene como objetivo determinar el potencial diagnóstico y las limitaciones del uso del Índice de Masa Corporal como único indicador del estado nutricional. Para ello se analizó una muestra constituida por 2155 sujetos de ambos sexos, con edades comprendidas entre los 6 y 18 años y pertenecientes a tres poblaciones jujeñas que difieren en ubicación altitudinal y nivel socieconómico (NSE): 1.) Susques, localidad rural situada a 3675 m.s.n.m; 2.) Alto Comedero, barrio perifér...

  2. Acanthaceae da Marambaia, Estado do Rio de Janeiro, Brasil

    OpenAIRE

    Braz,Denise Monte; Azevedo,Igor Henrique Freitas

    2016-01-01

    RESUMO Este trabalho consiste do tratamento taxonômico das Acanthaceae Juss. na Marambaia, Estado do Rio de Janeiro, e sua distribuição nas diferentes formações vegetais locais. Foram constatados cinco gêneros e nove espécies encontradas nos manguezais, na restinga e na floresta ombrófila, além de áreas urbanizadas. Thunbergia alata é introduzida e amplamente naturalizada no Brasil inteiro e Ruellia blechum é uma espécie neotropical também naturalizada; as demais espécies (Avicennia schaueria...

  3. Rol del estado en los ensayos clínicos

    Directory of Open Access Journals (Sweden)

    Pilar Mazzetti

    Full Text Available La regulación de los ensayos clínicos por el Estado es un proceso en constante cambio y adecuación, cuyo reto actual consiste en salvaguardar la seguridad de los participantes y equilibrar la carga administrativa. El desarrollo y la regulación de los ensayos clínicos en los distintos países varían según la realidad, el contexto, su ejecución nacional o multinacional, condicionando que la regulación puramente nacional resulte insuficiente y se precise conocer parte de la regulación internacional. El objetivo de esta publicación es mostrar una visión global del rol de Estado en la regulación de los ensayos clínicos en distintas realidades. Para ello, se ha realizado una revisión de la regulación en la Unión Europea, Estados Unidos de Norteamérica y algunos países de Latinoamérica, para llegar finalmente al Perú. La tendencia actual en la regulación de los ensayos clínicos, se caracteriza por el incremento en los estándares de calidad, el garantizar la seguridad de los participantes, promover la transparencia, la disminución de los procesos burocráticos y el fortalecimiento de los comités de ética, en el marco de procesos democráticos abiertos, que convoquen e integren a todos los interesados en procesos dinámicos basados en el conocimiento actual y los cambios que se suceden. El reto actual es promover el desarrollo de ensayos clínicos desde el Estado (universidades, centros de investigación, institutos especializados, hospitales, etc. para los aspectos que el país necesita, incluidos medicamentos huérfanos, enfermedades prevalentes y abandonadas, y el uso terapéutico de los principios activos originarios.

  4. Rol del estado en los ensayos clínicos

    Directory of Open Access Journals (Sweden)

    Pilar Mazzetti

    2012-12-01

    Full Text Available La regulación de los ensayos clínicos por el Estado es un proceso en constante cambio y adecuación, cuyo reto actual consiste en salvaguardar la seguridad de los participantes y equilibrar la carga administrativa. El desarrollo y la regulación de los ensayos clínicos en los distintos países varían según la realidad, el contexto, su ejecución nacional o multinacional, condicionando que la regulación puramente nacional resulte insuficiente y se precise conocer parte de la regulación internacional. El objetivo de esta publicación es mostrar una visión global del rol de Estado en la regulación de los ensayos clínicos en distintas realidades. Para ello, se ha realizado una revisión de la regulación en la Unión Europea, Estados Unidos de Norteamérica y algunos países de Latinoamérica, para llegar finalmente al Perú. La tendencia actual en la regulación de los ensayos clínicos, se caracteriza por el incremento en los estándares de calidad, el garantizar la seguridad de los participantes, promover la transparencia, la disminución de los procesos burocráticos y el fortalecimiento de los comités de ética, en el marco de procesos democráticos abiertos, que convoquen e integren a todos los interesados en procesos dinámicos basados en el conocimiento actual y los cambios que se suceden. El reto actual es promover el desarrollo de ensayos clínicos desde el Estado (universidades, centros de investigación, institutos especializados, hospitales, etc. para los aspectos que el país necesita, incluidos medicamentos huérfanos, enfermedades prevalentes y abandonadas, y el uso terapéutico de los principios activos originarios.

  5. Estado nacional, globalización y democracia

    Directory of Open Access Journals (Sweden)

    Wilson Alcides Valenzuela Pérez

    2018-02-01

    Full Text Available La definición de Estado nacional que Hans Kelsen expone en su obra clásica del pensamiento jurídico Teoría general del Derecho y del Estado lo caracteriza como organización política, que crea una comunidad nacional con el objeto de ejercer el poder político en el marco de un orden normativo válido para un espacio territorial delimitado, mediante el cual, se garantiza el principio de autodeterminación de un pueblo y su complemento necesario: la soberanía. Sin embargo, con motivo de los procesos de globalización, en particular, globalización de la economía de mercado, las decisiones más importantes que afectan al Estado se toman en los organismos económicos internacionales como el Fondo Monetario Internacional o el Banco Mundial, con lo cual, los principios de autodeterminación y de soberanía propios de la clásica definición del Estado nacional son puestos en cuestión y se han convertido en una mera ficción. Ante esa realidad, la idea de una sociedad cosmopolita, postulada por Kant hace ya más de doscientos años, retoma su vigencia, salvo que ahora, a la distancia histórica, la propuesta kantiana debe ser implementada por la democratización de los procesos de constitución de un nuevo orden mundial. El presente artículo explora la posibilidad de fortalecer la democracia gracias a una reconstrucción de los principios de la Ilustración, aplicados a una sociedad cosmopolita mediante la práctica del poder comunicativo de los ciudadanos que, suponemos, producirá el desencadenamiento de las libertades comunicativas en el horizonte teórico propuesto por Habermas.

  6. Effects of age on long-term outcomes after a routine invasive or selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes: a collaborative analysis of individual data from the FRISC II - ICTUS - RITA-3 (FIR) trials

    NARCIS (Netherlands)

    Damman, Peter; Clayton, Tim; Wallentin, Lars; Lagerqvist, Bo; Fox, Keith A. A.; Hirsch, Alexander; Windhausen, Fons; Swahn, Eva; Pocock, Stuart J.; Tijssen, Jan G. P.; de Winter, Robbert J.

    2012-01-01

    Objective To perform a patient-pooled analysis of a routine invasive versus a selective invasive strategy in elderly patients with non-ST segment elevation acute coronary syndrome. Methods A meta-analysis was performed of patient-pooled data from the FRISC IIeICTUSeRITA-3 (FIR) studies. (Un)adjusted

  7. Annabela Rita, Fernando Cristóvão (e ds., Daniela Marcheschi (Prefácio. Fabricar a Inovação – O Processo Criativo em Questão nas Ciências, nas Letras e nas Artes

    Directory of Open Access Journals (Sweden)

    Luísa Marinho Antunes

    2017-06-01

    Full Text Available Recensione del volume Annabela Rita e Fernando Cristóvão (eds. Fabricar a Inovação – O Processo Criativo em Questão nas Ciências, nas Letras e nas Artes, coord. Prefácio Daniela Marcheschi. Lisboa: Gradiva, 2016. Stampa (pp.396 seguita dalla versione italiana della Prefazione.

  8. Consumo energético-protéico e estado nutricional de crianças menores de cinco anos, no estado de Pernambuco, Brasil

    OpenAIRE

    Menezes,Risia Cristina Egito de; Osório,Mônica Maria

    2007-01-01

    OBJETIVO: Avaliar o consumo de energia e proteínas e associá-lo ao estado nutricional de crianças menores de 5 anos. MÉTODOS: Estudo transversal com 948 crianças menores de cinco anos, no Estado de Pernambuco. O consumo alimentar foi registrado utilizando o método recordatório de 24 horas. Para análise de energia e proteína foram utilizadas as Dietary Reference Intakes como referência, verificando-se o consumo mediano e a prevalência de inadequação. O estado nutricional foi avaliado utilizand...

  9. Corporatismo: el estado de la cuestión

    Directory of Open Access Journals (Sweden)

    SALVADOR GINER

    1985-01-01

    Full Text Available Se analizan las diferentes posturas acerca del debate que en torno al corporativismo se realiza en los países occidentales desarrollados. El debate en torno al corporativismo, según el autor, se centra principalmente en las políticas de concertación surgidas despúes de la Segunda Guerra Mundial. Se evalúa la principal bibliografía sobre el tema publicada en Inglaterra, Francia, Italia, Portugal, España y Estados Unidos desde 1974 hasta 1985, y se organiza en torno a los siguientes temas principales : los orígenes sociales del corporativismo ; definciones y tipos de corporativismo; causas y condiciones de las tendencias actuales del corporativismo; corporativismo, estado y democracia ; la inestabilidad del corporativismo. Un visión liberal del concepto lo ve como un intento de aproximación racional a la resolución de conflictos sociales y contradicciones existentes entre los diversos grupos de interés. Un punto de vista más radical del corporativismo señala el modo mediante el cual el capitalismo avanzado garantiza su estabilidad mediante la subordinación de las clases sociales a los "contratos sociales corporativos". Según el autor, se puede concluir que el "corporativismo" es una amplia tendencia a través de la cual la desigualdad social y los conflictos sociales se articulan en las sociedades avanzadas capitalistas.

  10. La demanda de etanol en Estados Unidos, 1981-2009

    Directory of Open Access Journals (Sweden)

    Luis Armando Becerra Pérez

    2012-01-01

    Full Text Available En este artículo se define una función de demanda del etanol para la economía de Estados Unidos. Se realizó un ejercicio de cointegración, con series de tiempo para el periodo 1981-2009, utilizando la metodología de Johansen. Se encontró el vector normalizado de cointegración, y los resultados coinciden con los signos teóricos esperados. Éstos indican que la demanda de etanol es muy elástica a su precio, pero lo es aún más al de la gasolina, y también resultó ser muy inelástica a la venta final automotriz. Por lo tanto, ante un escenario internacional de precios alcistas del petróleo y, por consiguiente de la gasolina, la demanda de etanol en Estados Unidos aumentará consistentemente en el tiempo, con lo que también tenderán a hacerlo las importaciones de este biocombustible.

  11. Pb and Sr isotopic systematics of some basalts and sulfides from the East Pacific Rise at 21/sup 0/N (project RITA)

    Energy Technology Data Exchange (ETDEWEB)

    Vidal, P. (Centre National de la Recherche Scientifique, 35 - Rennes (France). Centre Armoricain d' Etude Structurale des Socles); Clauer, N. (Centre National de la Recherche Scientifique, 67 - Strasbourg (France). Centre de Sedimentologie et Geochimie de la Surface)

    1981-10-01

    Tholeiitic basalts and sulfide deposits from the 'Cyana' and 'Alvin' diving programs (RITA project) on the East Pacific Rise were analyzed for Pb and Sr isotopes. The basalt data plot within the field defined previously by other East Pacific Rise basalts (/sup 206/Pb//sup 204/Pb: 18.35-18.58; /sup 207/Pb//sup 204/Pb: 15.48-15.53; /sup 208/Pb//sup 204/Pb: 37.8-38.1; /sup 87/Sr//sup 86/Sr: 0.7022-0.7025). Pb, U and Sr contents (approx. equal to 0.5, approx. equal to 0.05 and approx. equal to 110 ppm, respectively) and ..mu.. values (approx. equal to 6) are typical of MORB, whereas Th/U ratios (approx. equal to 3.5) are significantly higher. The Pb isotopic ratios of the sulfide samples are very homogeneous (/sup 206/Pb//sup 204/Pb approx. equal to 18.47, /sup 207/Pb//sup 204/Pb approx. equal to 15.49, /sup 208/Pb//sup 204/Pb approx. equal to 37.90), and plot in the middle of the basalt field. This indicates that the sulfide Pb was derived from the basaltic crust without any significant contribution from either seawater or hemipelagic sediments, and the solutions from which the sulfiedes were deposited had uniform Pb isotopic composition. The Pb contents of three sulfide samples is relatively high (170-1310 ppm). The Sr contents of five sulfide samples are widely scattered from 12 to 210 ppm, with /sup 87/Sr//sup 86/Sr ratios intermediate between basaltic and seawater values (0.70554 +- 0.00005 to 0.70795 +- 0.00011). Leaching experiments show that both basalt-derived Sr and seawater Sr were present in the solutions which deposited the sulfides. In some cases, Sr was also adsorbed from seawater onto the sulfides following their deposition. Basalt-derived Sr and seawater Sr are also present in associated non-sulfide phases.

  12. LA MIGRACIÓN DE RETORNO DESDE ESTADOS UNIDOS HACIA EL ESTADO DE MÉXICO : OPORTUNIDADES Y RETOS

    Directory of Open Access Journals (Sweden)

    Jaciel Montoya Arce

    2011-01-01

    Full Text Available En este artículo se analiza la migración de retorno en el Estado de México, desde la perspectiva personal y del hogar. Se utiliza, para tal efecto, la base de datos de la Encuesta sobre Migración de Mexiquenses a Estados Unidos (EMMEU, 2009, que captó, entre otros aspectos de la migración, cuántos y qué tipos de migrantes se encuentran de regreso en la entidad, así como las habilidades que traen consigo, la forma en que las utilizan y las limitaciones actuales que enfrentan para desplegarlas en su totalidad. Esto permitió detectar que los migrantes de retorno traen consigo una nueva mentalidad socioeconómica y familiar que se manifiesta en sus prácticas cotidianas, como un mayor impulso a la educación de sus hijos y su salud, capitalización de pequeños negocios, cambios de empleo del campo a las actividades terciarias. A partir de ello, es necesario potenciar el uso de estas habilidades socioproductivas por la vía de los programas públicos de apoyos concretos, según las necesidades de los retornados en sus familias y comunidades.

  13. Estados de mal epiléptico na sindrome Delennox-Gastaut: aspectos terapeuticos

    Directory of Open Access Journals (Sweden)

    José Geraldo Speciali

    1977-09-01

    Full Text Available Foram descritas as condutas terapêuticas utilizadas nos estados de mal epiléptico, convulsivos e não convulsivos, observados em 14 pacientes com síndrome de Lennox-Gastaut. Verificou-se relação temporal entre aparecimento de estado de mal epiléptico e início de tratamento com clonazepam e difenilhidantoina; a retirada dessas medicações foi seguida pelo desaparecimento dos estados de mal. Indicou-se a possibilidade de tratamento dos estados de mal epiléptico modificando-se o esquema terapêutico administrado por via oral, reservando-se o tratamento parenteral para os estados com comprometimento progressivo da consciência e/ou dos distúrbios neurovegetativos.

  14. Crecimiento y estado nutricional infantil en San Salvador de Jujuy

    Directory of Open Access Journals (Sweden)

    Bejarano, Ignacio

    2001-01-01

    Full Text Available La recolección de datos antropométricos dentro de un programa de asistencia sanitaria y alimentaria permite definir el estado nutricional y de salud de los individuos y en base a esta información planificar, ejecutar y valorar la incidencia de dicho programa en la población. El objetivo de este trabajo fue evaluar el crecimiento y estado nutricional de una población infantil (1-5 años residente en barrios periféricos de San Salvador de Jujuy y comprendida en el Programa Materno Infantil (PROMIN. Los datos procedieron de mediciones de peso (kg y talla (cm realizadas en 4616 niños, los que se agruparon por sexo y edad decimal. Los indicadores utilizados fueron: peso, talla, puntuación z (Pz, índice de masa corporal (IMC. Los resultados indicaron que: 1 la mayoría de la población se encontró entre 2z: 98,9% para talla/edad (T/E y 96.6% para peso/edad (P/E (estándar nacional; 99.4% para T/E y 97.7% para P/E (estándar internacional; 2 los valores promedios del IMC en todos los grupos de edad y en ambos sexos, fueron superiores a los de referencia, resultando estas diferencias estadísticamente significativas (p<0.01. Se concluye que el crecimiento y el estado nutricional de esta población se ajusta al de las poblaciones de referencia nacional e internacional y que, probablemente este comportamiento, el cual no refleja la situación general del resto de las poblaciones infantiles de la Provincia de Jujuy, responda al efecto de la asistencia alimentaria, médica y sanitaria ofrecida por el PROMIN y a las características socioeconómicas, demográficas y culturales propias de esta población infantil.

  15. La sede del Archivo de Estado de Florencia

    Directory of Open Access Journals (Sweden)

    Blanca González Talavera

    2009-12-01

    Full Text Available Los protagonistas del presente artículo son el glorioso palacio de los Uffizi (siglo XVI y la nueva sede para archivo de Piazza Beccaria en Florencia (siglo XX, reflejo de sociedades y culturas opuestas en el tiempo, pero  sin  embargo unidos en  su  responsabilidad: custodiar el Archivo de  Estado de  Florencia.  El  análisis histórico-artístico de cada uno de los edificios como “continentes” de un grueso documental de incalculable valor  es el principal  objetivo  de este  artículo.

  16. Gobernabilidad, transparencia y reconstrucción del Estado

    Directory of Open Access Journals (Sweden)

    Ricardo Uvalle Berrones

    2008-01-01

    Full Text Available ´En este artículo, se analiza la relación entre gobernabilidad, transparencia y reconstrucción del Estado a la luz de las transformaciones democráticas que viven las sociedades contemporáneas. El trabajo destaca el vínculo entre gobernanza y transparencia con el fin de puntualizar el comportamiento que tienen los cuerpos burocráticos ante las condiciones propias de la democracia. Se incluye, además, una sección en la cual se reflexiona sobre la transparencia en el caso de México tomando en cuenta su inserción en una democracia más plena.

  17. La guerra contra el terrorismo y el estado de derecho

    Directory of Open Access Journals (Sweden)

    Owen M. Fiss

    2009-01-01

    Full Text Available La guerra contra el terrorismo -expresión política que se ha empleado para movilizar a la sociedad estadounidense hacia sucesivas guerras después de los ataques del 11 de septiembre- ha tenido consecuencias especialmente gravosas para Estados Unidos, pero muy especialmente para la Constitución y el imperio del derecho. En este artículo se revisan las políticas y prácticas que han puesto en entredicho el imperio del derecho en temas tan vitales y sensibles como la prohibición de la tortura, la privacidad de las comunicaciones entre privados, el debido proceso y las garantías procesales.

  18. Valoración del crecimiento: estado nutricio

    OpenAIRE

    Nelly Altamirano Bustamante; Myriam Altamirano Bustamante; Alejandro Valderrama Hernández; Hortencia Montesinos Correa

    2015-01-01

    INTRODUCCIÓN La valoración adecuada del estado nutricional es un requisito indispensable en la vigilancia pediátrica del niño sano e imperativa en el niño enfermo, permite la identificación temprana de alteración y la posibilidad de tratamiento oportuno, además de prevención primaria de desarrollo futuro de obesidad o de desnutrición y por ende de enfermedades crónico degenerativas. El peso es un marcador indirecto de la masa proteica y de los almacenes de energía. Pero… ¿Cuál es el p...

  19. Sobre la complejidad del Estado y las contrataciones administrativas

    Directory of Open Access Journals (Sweden)

    Armando Rodriguez García

    2011-12-01

    Full Text Available El tema de los contratos que celebra el Estado ha significado un tema de interés constante para el Derecho administrativo, debido a las particularidades que adoptan las figuras contractuales aplicadas en el sector público en el orden científico. Adicionalmente ese interés se ha incrementado con la ampliación del empleo de los contratos -con ocasión de los cambios operados por la globalización-. El enfoque que se ofrece a continuación apunta a la consideración de la complejidad presente en la acción pública, para así comprender mejor el entorno de los contratos públicos y su alcance, y obtener una clara perspectiva sobre lo que aporta el Derecho administrativo global.

  20. Los santos patronos de los migrantes Mexicanos a Estados Unidos

    Directory of Open Access Journals (Sweden)

    Rafael Alarcón

    Full Text Available La mayor parte los migrantes mexicanos indocumentados que buscan encontrar un empleo en Estados Unidos son católicos, por esta razón, han incorporado a la devoción de los santos patronos sus tribulaciones que incluyen el trayecto desde sus comunidades de origen a la frontera norte, los peligros del cruce indocumentado, la búsqueda de trabajo y la posible deportación. El objetivo central de este artículo es analizar las características más importantes de tres devociones de los migrantes indocumentados en Tijuana, Baja California, México: Santo Toribio Romo, el "Santo Pollero" que fue canonizado en 2000, el Beato Juan Bautista Scalabrini, fundador de los Misioneros Scalabrinianos y Juan Soldado quien surgió de la religiosidad popular.

  1. Miguel Antonio Caro, el Banco Nacional y el Estado

    Directory of Open Access Journals (Sweden)

    Salomón Kalmanovitz

    1999-09-01

    Full Text Available La Regeneración fue el movimiento político y Miguel Antonio Caro el ideólogo que hicieron que Colombia retornara a la matriz institucional centralizada legada por los españoles, en reacción a la dirección liberal y federalista que pretendió orientarla por la senda del desarrollo capitalista, vía su integración al mercado mundial. Esta fue una tendencia continental, de acuerdo con Douglass North, aún en países donde los liberales ganaron las guerras civiles del siglo XIX (North, 134-135. En este ensayo se trata de analizar el pensamiento económico de Caro y más precisamente sus percepciones sobre la banca central, como parte integral de su concepción del Estado que terminaron por imponerse para la Colombia del siglo XX.

  2. Internet e identidad nacional: Estado, dominios y comunidades virtuales

    Directory of Open Access Journals (Sweden)

    Àlvar Peris

    2010-01-01

    Full Text Available Este artículo trata de analizar hasta qué punto las tecnologías de la información y la comunicación, especialmente Internet, están contribuyendo a transformar los conceptos tradicionales en torno a la identidad nacional y a socavar la soberanía del Estado-nación, tal y como se sostiene desde distintos foros, en un momento de profundos cambios asociados a la globalización. This paper tries to analyze the extent to which information and communication technologies, especially the Internet, are contributing to the transformation of traditional concepts of national identity and the undermining of nation-state sovereignty, as several forums maintain, at a moment of profound changes associated with globalization.

  3. La Nariz Electrónica: Estado del Arte

    Directory of Open Access Journals (Sweden)

    Iveth Moreno

    2009-07-01

    Full Text Available Resumen: En este trabajo se presenta el estado del arte de los sistemas olfativos artificiales o narices electrónicas, su funcionamiento y algunas de sus aplicaciones. Además, se revisa el concepto de olfato electrónico, pasando por sus aplicaciones más relevantes. Posteriormente, se analizan las similitudes del funcionamiento de la nariz electrónica con el sistema del olfato humano. Finalmente, se incluyen los conceptos más importantes relacionados con la instalación de narices electrónicas sobre robots móviles, destacando sus consiguientes aplicaciones. Palabras clave: nariz electrónica, sensor de olor, técnicas de reconocimiento de patrones, robots móviles.

  4. Estado, mercado de tierra urbana e inundaciones en ciudades argentinas

    Directory of Open Access Journals (Sweden)

    Nora Clichevsky

    2006-01-01

    Full Text Available En este trabajo se presentan los resultados de una investigación sobre las relaciones que se establecen entre los mercados de tierra urbana y las inundaciones en ciudades argentinas, en el marco más amplio de la vulnerabilidad urbana. Se pretende despejar incógnitas acerca del papel jugado por el Estado como regulador del mercado en áreas urbanas con vulnerabilidad natural a la inundación y como constructor de defensas contra las inundaciones y acerca de los impactos que han tenido las inundaciones y las obras de defensa contra ellas sobre el mercado de tierra y, por lo tanto, sobre el acceso al suelo urbano por parte de los distintos sectores de la población.

  5. Estado nacional y nacionalidades indígenas.

    Directory of Open Access Journals (Sweden)

    José Mauro Gagliardi

    2011-08-01

    Full Text Available Cuando se estudian los pueblos indígenas de Brasil la primera cosa que se constata es su reducción de mayoría a minoría. Los traslados del interior para el litoral, las matanzas y las epidemias son hechos que sirven para ilustrar ese proceso de exterminación. A partir del siglo XVIII, com la administración pombalina se inició la formación delEstado Nacional que de forma planificada impuso a los indios una forma de actuar y de pensar. La finalidad del reglamento sobre las misiones de catequesis y civilización de los indios de 1845 era también la de incorporarlos a los patrones de vida occidentales. Se trataba de preparar a esos pueblos para un tipo de trabajo uniformado, hablando la lengua nacional, como una conciencia económica y cultural homogénea. Durante el periodo republicano, los mecanismos de integración de los pueblos indígenas a la sociedad nacional se hicieron todavía más eficaces. Si tomamos como referencia la formación del Estado Nacional verificaremos que es una tendencia de esa forma de organización política la de uniformizar las relaciones sociales y disolver la diversidad cultural. El estudio de ese fenómeno ayudará para la comprensión más profunda de las relaciones entre los indios y la sociedad brasileña y probablemente ayudará a programar estrategias que aseguren la vida de aquellos que todavía sobreviven.

  6. Felismina e Libertina vão à escola: notas sobre a escolarização nas freguesias de Santa Rita e Santana (Rio de Janeiro, 1888-1906 - Felismina and Libertina go to school: notes on schooling in the parishes of Santa Rita and Santana (RJ, 1888-1906

    Directory of Open Access Journals (Sweden)

    Alessandra Frota Martinez Schueler

    2015-05-01

    Full Text Available Neste artigo se analisa as possibilidades, tensões e limites da escolarização na cidade do Rio de Janeiro, no período da abolição e no pós-abolição (1888-1906. A pesquisa incide sobre regiões de alta densidade demográfica, com índices crescentes de matrículas nas escolas públicas. Pensar o contexto do pós-abolição no âmbito da história da educação visa a compreender como os projetos nacionais e locais direcionados à instrução popular interagiam com expectativas e ações de libertos e livres, em diálogo com os estudos historiográficos concernentes às lutas dessa população pelo acesso à educação.  Palavras-chave: escolarização, pós-abolição, Rio de Janeiro.FELISMINA AND LIBERTINA GO TO SCHOOL: NOTES ON SCHOOLING IN THE PARISHES OF SANTA RITA AND SANTANA (RIO DE JANEIRO, 1888-1906 AbstractThe article analyzes the possibilities, tensions and limits of schooling in the city of Rio de Janeiro, in the period during the slavery abolition and post-abolition (1888-1906. The research focuses on regions of high population density, with increasing enrollment rates in public schools. Thinking the context of post-abolition within the history of education aims to understand how national and local projects targeted at popular instruction interacted with expectations and actions of freedmen and free people in a dialogue with historiographical studies concerning the struggles of this population for educational access.Key-words: schooling, post-abolition, Rio de Janeiro.FELISMINAY LIBERTINA VAN A LA ESCUELA: NOTAS SOBRE LA ESCOLARIZACIÓN EN LAS FELIGRESÍAS DE SANTA RITA Y SANTANA ResumenEl artículo analiza las posibilidades, las tensiones y los límites de la escolarización en la ciudad de Río de Janeiro, en el período de la abolición y post-abolición (1888-1906. Esta investigación está centrada en las regiones con alta densidad de población, con índices crecientes de matrículas en las escuelas públicas. Se

  7. DEFINICIÓN DE UN MODELO DE SEGURIDAD PARA LA RED DE INVESTIGACIÓN DE TECNOLOGÍA AVANZADA DE LA UNIVERSIDAD DISTRITAL “FRANCISCO JOSÉ DE CALDAS” RITA-UD

    Directory of Open Access Journals (Sweden)

    Diego Rocha

    2011-11-01

    Full Text Available Uno de los aspectos más importantes dentro de las networking se relaciona con la protección de la información. Este trabajo permite identificar los aspectos más importantes a considerar en la definición de un modelo de seguridad para la red de investigación de tecnología avanzada de la Universidad Distrital Francisco José de Caldas RITA-UD basado en la aplicación de las normas ISO27001 y NTC-ISO/IEC17799.El diseño final obtenido es una propuesta para la implementación de un Firewall Cisco ASA5520.

  8. Estimadores de estado en redes de distribución: revisión del estado del arte

    OpenAIRE

    Gámiz Juárez, María de los Ángeles

    2016-01-01

    La Estimación de Estado en Sistemas de Distribución está llegando a ser un elemento esencial de los sistemas de gestión de la distribución, sirviendo como base de numerosas aplicaciones dirigidas a las redes inteligentes o, también conocidas como SMART GRIDS. En este documento se va a tratar la evolución de este método desde su origen hasta la actualidad. Se describirán las distintas metodologías de resolución de esta problemática, se mostrarán las topologías existentes realizando una clasifi...

  9. Environmental chemical data for perishable sediments and soils collected in New Orleans, Louisiana, and along the Louisiana Delta following Hurricanes Katrina and Rita, 2005

    Science.gov (United States)

    Witt, Emitt C.; Shi, Honglan; Karstensen, Krista A.; Wang, Jianmin; Adams, Craig D.

    2008-01-01

    In October 2005, nearly one month after Hurricanes Katrina and Rita, a team of scientists from the U.S. Geological Survey and the Missouri University of Science and Technology deployed to southern Louisiana to collect perishable environmental data resulting from the impacts of these storms. Perishable samples collected for this investigation are subject to destruction or ruin by removal, mixing, or natural decay; therefore, collection is time-critical following the depositional event. A total of 238 samples of sediment, soil, and vegetation were collected to characterize chemical quality. For this analysis, 157 of the 238 samples were used to characterize trace element, iron, total organic carbon, pesticide, and polychlorinated biphenyl concentrations of deposited sediment and associated shallow soils. In decreasing order, the largest variability in trace element concentration was detected for lead, vanadium, chromium, copper, arsenic, cadmium, and mercury. Lead was determined to be the trace element of most concern because of the large concentrations present in the samples ranging from 4.50 to 551 milligrams per kilogram (mg/kg). Sequential extraction analysis of lead indicate that 39.1 percent of the total lead concentration in post-hurricane sediment is associated with the iron-manganese oxide fraction. This fraction is considered extremely mobile under reducing environmental conditions, thereby making lead a potential health hazard. The presence of lead in post-hurricane sediments likely is from redistribution of pre-hurricane contaminated soils and sediments from Lake Pontchartrain and the flood control canals of New Orleans. Arsenic concentrations ranged from 0.84 to 49.1 mg/kg. Although Arsenic concentrations generally were small and consistent with other research results, all samples exceeded the U.S. Environmental Protection Agency’s Human Health Medium-Specific Screening Level of 0.39 mg/kg. Mercury concentrations ranged from 0.02 to 1.30 mg

  10. Contaminación enteroparasitaria de lechugas expendidas en mercados del estado Lara. Venezuela

    OpenAIRE

    TRAVIEZO-VALLES, LUIS; DÁVILA, JUAN; RODRÍGUEZ, RICARDO; PERDOMO, OMAIRA; PÉREZ, JOSÉ

    2004-01-01

    Para determinar la contaminación de lechugas con enteroparásitos, se analizaron 100 muestras (50 lechuga americana y 50 lechuga romana) cultivadas en tres lugares distintos, Timotes y Bailadores (estado Mérida) y Chejendé (estado Trujillo) y expendidas en cuatro mercados diferentes del estado Lara: Terepaima, Cabudare, Las Trinitarias y Central. Las lechugas fueron procesadas según la técnica de Álvarez et al, modificada, detectando contaminación en el 29% de las muestras (16 LA y 13 LR) iden...

  11. Exploración conceptual de la responsabilidad patrimonial del Estado frente al desplazamiento forzado.

    OpenAIRE

    López-Martínez, Miguel-Andrés

    2013-01-01

    El propósito central de la propuesta de investigación es responder a la siguiente pregunta: ¿la proliferación de respuestas teóricas al desplazamiento forzado, impulsada con la declaratoria del estado de cosas inconstitucional (ECI) en 2004, generó algún cambio en el paradigma de la responsabilidad patrimonial del Estado (REPE), que orientó al Consejo de Estado al definir la responsabilidad de las autoridades por desplazamiento forzado (DEFO), entre 2004 y 2010? Para lograrlo, comenzamos por ...

  12. Direito, estado e poder: poulantzas e o seu confronto com Kelsen

    OpenAIRE

    Luiz Eduardo Motta

    2011-01-01

    A Teoria do Estado, no campo da Ciência Política, viveu momentos de crise, em particular na passagem dos anos 1980 para os 1990, quando algumas correntes intelectuais apontavam que o Estado-nação e as instituições estatais deixariam de ocupar um papel central como objetos de análise. O presente artigo vai de encontro a essa posição e visa a estabelecer uma análise comparativa de dois dos mais sistemáticos autores que trataram do conceito de Estado moderno e da relação deste com o Direito mode...

  13. Pakistán: Estado Fallido, débil o colapsado

    Directory of Open Access Journals (Sweden)

    Alberto Priego

    2012-05-01

    Full Text Available Desde que se convirtiera en un Estado independiente en 1947, Pakistán ha arrastrado una serie de lastres que han limitado su desarrollo como Estado. Entre otros problemas podemos destacar como una composición étnica muy heterogénea, especialmente en el el norte y este del país, o el tráfico de drogas extendido por todo el país. Estas circunstancias han llevado a Pakistán a las principales indices de estados fallidos.

  14. Estado Vital de la Materia. Su origen, su evolución y su futuro.

    OpenAIRE

    J. Hernando Ordoñez

    2001-01-01

    En este artlculo se hacen algunas observaciones sobre un estado de la materia (estado vital), propuesto para reemplazar el de materia viva, que se usa habitualmente.

    La materia en estado vital se organiza por una fuerza interna, que podríamos calificar como inteligente, que hace que los átomos se orienten y se organicen con determinada finalidad para fabricar células, para modelar órganos y, éstos, para culminar su obra integrándose con la armonía más admirable, par...

  15. AS VARIANTES DE SOTAQUE NO TERRITÓRIO DO ESTADO DE MINAS GERAIS- BRASIL

    OpenAIRE

    Assaid Dermínio, Marina

    2012-01-01

    Este trabalho tem por objetivo abordar as variações fonéticas (sotaque) da língua portuguesa, especificamente, no estado de Minas Gerais- Brasil. O estudo mostra que devido à localização geográfica dentro do território brasileiro, o sotaque dos falantes varia de acordo com a região, haja vista que o estado de Minas Gerais faz fronteira com mais seis outros estados, sendo eles: Bahia, Goiás, Mato Grosso do Sul, São Paulo, Rio de Janeiro, e Espírito Santo. O trabalho abordará o fato de que cada...

  16. Boophilus microplus: estado actual de la resistencia a los acaricidas en la frontera México Estados Unidos y su impacto en la relación comercial

    Directory of Open Access Journals (Sweden)

    Juan Ramón González Sáenz Pardo

    2012-01-01

    Full Text Available Se aborda la importancia de las exportaciones de ganado bovino en pie a los Estados Unidos de América, destacando el valor comercial que representa para México la entrada de divisas por 700 millones USD anuales por este concepto. La comercialización de ganado se ve frenada por barreras no arancelarias, tales como la tuberculosis (TB, brucelosis y las garrapatas. Se ha formado un grupo binacional de expertos para tratar estos temas. En el tema de garrapatas se han establecido sistemas de colaboración entre ambos países para la identificación de especies de garrapatas y la rastreabilidad de los casos que sean cuarentenados, desde la línea fronteriza hasta su origen en los diferentes estados mexicanos. Se generó un Proyecto de la Franja Fronteriza para la erradicación de la garrapata Boophilus en los estados mexicanos limítrofes con el estado de Texas, consistente en la identificación de predios infestados, tratamientos ixodicidas e inspección del ganado para exportación a los Estados Unidos. Se discuten las acciones que ambos países están llevando a cabo para la erradicación de garrapata Boophilus en la frontera y para evitar la llegada de ganado con garrapatas a las estaciones cuarentenarias de exportación. Se concluye sobre la necesidad de reforzar y mejorar estos programas.

  17. Desenvolvimento vegetativo de abacaxizeiros 'Pérola' e 'Smooth Cayenne' no Estado da Paraíba Vegetative development of Pérola and Smooth Cayenne pineapple cultivars in the state of Paraíba

    Directory of Open Access Journals (Sweden)

    Alessandra Alves Rodrigues

    2010-03-01

    Full Text Available Este trabalho teve por objetivo avaliar o desenvolvimento vegetativo de abacaxizeiros 'Pérola' e 'Smooth Cayenne' nas condições edafoclimáticas de Santa Rita, Estado da Paraíba. Foram realizados dois experimentos, um para cada cultivar, em Espodossolo Ferrocárbico de textura arenosa, entre junho de 2003 e setembro de 2004. O delineamento experimental foi o de blocos casualizados, com cinco tratamentos (avaliações aos 4; 6; 8; 10 e 12 meses após o plantio e cinco repetições. Foram avaliadas as variáveis de altura da planta, produção de matéria fresca e seca de raízes, caule e folhas e de matéria fresca da folha 'D' na época de indução floral. Os resultados mostraram que as plantas da cv. Pérola apresentaram maiores valores de altura (133 e 100 cm, matéria fresca (263 e 255 g e seca de raiz (80 e 60 g, matéria fresca (310 e 200 g e seca de caule (86 e 20 g em relação à cv. Smooth Cayenne. O acúmulo de matéria fresca e seca das folhas intensificou-se a partir dos oito meses após o plantio, sendo maior para a cv. Pérola, e obedeceu à seguinte sequência: D>C>B>A. As plantas das duas cultivares apresentaram valores de matéria fresca da folha 'D' na época de indução floral superiores a 80 g (118 g para a 'Pérola' e 81 g para a 'Smooth Cayenne', demonstrando a possibilidade de antecipação desta prática.This study was carried out to evaluate the vegetative development of both pineapple plants 'Pérola' and 'Smooth Cayenne' under the edaphoclimatic conditions in Santa Rita county, in the state of Paraíba. Two experiments were conducted, being one for each cultivar, during the period from June 2003 to September 2004 and the sandy-textured 'Espodossolo Ferrocárbico' was used. The randomized block experimental design was used, with five treatments (evaluations at 4, 6, 8, 10 and 12 months after planting and five replicates. The following variables were evaluated: plant height, both fresh and dry matter yield of the

  18. Los trastornos del estado de ánimo

    Directory of Open Access Journals (Sweden)

    Roberto Anselmo Ramos Valverde

    2014-09-01

    Full Text Available Normalmente el ser humano puede experimentar una gran variedad de manifestaciones afectivas, que van desde el estado normal hasta el ánimo elevado o depresivo. Los trastornos primarios de la afectividad están caracterizados por sensaciones subjetivas de malestar y por una pérdida del sentido de control, las cuales se acompañan, además, de cambios en el nivel de actividad, en las funciones cognitivas, en el lenguaje y en las funciones vegetativas como el sueño, apetito, actividad sexual y otros ritmos biológicos. (1 Los trastornos del estado de ánimo (del humor afectivo constituyen un conjunto heterogéneo de entidades nosológicas que abarcan el espectro afectivo, incluyendo las formas polares maníacas y depresivas, así como las formas clínicas mixtas y atípicas, siendo descritas estas últimas por los clásicos de la Psiquiatría y que son el resultado de las influencias socioculturales, propias de cada región o país, constituyendo verdaderos patrimonios que comparten la medicina y la cultura. (1 Sus primeras descripciones ocurrieron en el período greco-romano, con los exégetas del Corpus Hipocraticum, al considerar la manía y la melancolía en la clasificación de las enfermedades mentales; la manía se caracterizaba por estados de excitación psicomotora, mientras que la melancolía se designaba a estados depresivos. (1 Posteriormente Pinel incluyó ambas enfermedades en su clasificación de las enfermedades mentales y la escuela francesa conceptualiza en 1854, la folie circulaire de Falret y la folie a doublé forme de Baillanger, pero su reconocimiento taxonómico definitivo aconteció gracias a la obra de Emil Kraepelin en el siglo XIX, quien desde entonces tuvo la genial concepción que la melancolía involutiva no era un ente nosológico, aparte a la otrora psicosis maníaco depresiva. (1 Los estudios genéticos y bioquímicos han demostrado el componente hereditario de estos trastornos, que sientan su base material en

  19. Forjando el Estado Neoliberal: Workfare, Prisonfare e Inseguridad Social

    Directory of Open Access Journals (Sweden)

    Loïc Wacquant

    2011-12-01

    Full Text Available En Castigar a los pobres, mostré que el ascenso del Estado Penal en los Estados Unidos y otras sociedades avanzadas en el último cuarto de siglo es una respuesta a la creciente inseguridad social y no a la inseguridad criminal, que los cambios en la asistencia social y las políticas judiciales están vinculados entre sí, el tan restrictivo workfare y el tan expansivo prisonfare se unen en un artefacto único de organización para la disciplina de las fracciones precarizadas de la clase trabajadora en la era post-industrial, y que un sistema carcelario diligente no es una desviación, sino un elemento constitutivo del Leviatán neoliberal. En este artículo, extraigo las consecuencias teóricas de ese diagnóstico respecto al gobierno emergente de la inseguridad social. Utilizo el concepto de campo burocrático de Bourdieu para revisar la tesis clásica de Piven y Cloward sobre la regulación de la pobreza a través de la asistencia público, y contrastar el modelo de penalización como técnica para la gestión de la marginalidad urbana con la visión de Michel Foucault sobre la sociedad disciplinaria, las consideraciones de David Garlad sobre la cultura del control y la caracterización de David Harvey acerca de la política neoliberal. Contra la concepción estrecha del neoliberalismo como una regla del mercado, se propone una especificación de mayor densidad sociológica que implica prestaciones sociales de supervisión, un estado penal proactivo y el tropo cultural de la responsabilidad individual. Esto sugiere que es necesario teorizar, no respecto a la prisión como una técnica práctica para aplicar la ley, sino como un núcleo cuya capacidad política selectiva y agresiva descargada sobre las regiones inferiores del espacio social viola los ideales de la ciudadanía democrática.In Punishing the Poor, I show that the ascent of the penal state in the United States and other advanced societies over the past quarter-century is a

  20. Mapeamento de Empresas Industriais no Estado de Mato Grosso

    Directory of Open Access Journals (Sweden)

    Rafael Vitaliano Ferreira Coelho

    2014-12-01

    Full Text Available O presente estudo objetivou mapear potenciais Arranjos Produtivos Locais (APLs Industriais no estado de Mato Grosso, por meio de dados quantitativos de Unidades Empresariais e Industriais, obtidos pelo Banco de Dados da JUCEMAT – Junta Comercial do Estado de Mato Grosso, no período de janeiro de 2010 a dezembro de 2013. Foi adotado como metodologia de identificação de APLs potenciais o Coeficiente Locacional (QL. A partir dos dados, foram feitas análises buscando evidenciar as aglomerações industriais dentre o universo total de empresas distribuídas entre os 141 municípios mato-grossenses. Os resultados indicaram cerca de 70 municípios potenciais especialistas em indústria extrativa no período entre 2010 e 2013, sendo que 14 foram classificadas no 1º quartil dos municípios com QL>1 em todo o período. Além disso, cerca de 68 municípios apresentaram QL>1 para indústria de transformação e 12 locais encontram-se no 1º quartil deste grupo no período 2010-2013. De forma geral, a mesorregião Norte Mato-grossense apresentou maior aglomeração de municípios especializados em indústria, indicando potencial de adensamento produtivo. Em que pese a reduzida participação da indústria extrativa no PIB regional, o número de empreendimentos extrativos cresceu a uma taxa geométrica de 3,88% ao ano entre 2010 e 2013, frente a uma expansão de 4,64% de todo o tecido empresarial e de 0,22% das indústrias transformadoras no mesmo período. Concluem-se da necessidade de criação de mecanismos de atratividade e adensamento dos APLs potenciais industriais, aproveitando o nível de especialização existente para que haja maior agregação de valor dos produtos agropecuários de Mato Grosso.

  1. La Defensa, Política de Estado

    Directory of Open Access Journals (Sweden)

    Muñoz-Alonso, Alejandro

    2008-12-01

    Full Text Available The areas of the State Policy are set, specially focussing on the Defense as it is closely related to concepts like National Interest and Anglo-Saxon bipartisan policy. Nevertheless, the political alternation will cause differences. It is also necessary to tell the difference between the State Policy and the Policy carried out by the State. That’s why the democratic Parliaments play a fundamental role in shaping the defence policy. Although the Parliament symbolizes the National Sovereignty there can be and there are actually differences with the Public Opinion. This sort of divorce is not really new as, in Spain, it became evident in a very intensive way on the occasion of decisions such as the Spanish entry into the NATO. A State Policy related to Defense, kept during a long time and resistant to political alternation would certainly be the best instrument to reach a culture of defense.Se establecen los ámbitos de las políticas de estado, con especial énfasis en la Defensa al estar esta vinculada al concepto de interés nacional, y al anglosajón bipartisan policy. No obstante, la alternancia política va a crear discrepancias. Conviene diferenciar la “Política de Estado” y la “Política del Estado”. Por ello, los Parlamentos democráticos juegan un papel fundamental en la conformación de la política de defensa. Pese a que el Parlamento representa a la soberanía nacional pueden producirse, y de hecho se producen, discrepancias con la opinión pública. Este divorcio no es nuevo y en España se ha manifestado de forma muy intensa con ocasión de tomas de decisión como la incorporación a la OTAN. Una política de Estado en defensa, mantenida en el tiempo y resistente a las alternancias políticas sería el instrumento más adecuado para lograr una cultura de defensa.

  2. El papel de los comités Pro-Estado en la creación del estado de Baja California

    Directory of Open Access Journals (Sweden)

    Lawrence Douglas Taylor

    1999-01-01

    Full Text Available El artículo trata del papel de los Comités Pro-Estado en la formación de Baja California como estado. Se analizan las raíces de la autonomía política en la península, que se remontan al Porfiriato, así como el impacto de la Revolución Mexicana sobre este proceso. Se examinan los diversos movimientos pro- estado que surgieron de 1929 en adelante la composición de sus grupos de integrantes, sus objetivos y contribuciones principales en términos de dirigir el sentimiento popular hacia la realización de esta meta.

  3. Conflicto armado colombiano, estado mínimo y utopías

    Directory of Open Access Journals (Sweden)

    Boris Salazar

    2002-12-01

    Full Text Available Se recurre al enfoque de Robert Nozick (Anarquía, Estado y Utopía, para analizar la situación actual del Estado colombianos. Nozick se basa en la teoría económica para representar a los grupo como competidores en un mercado que vende protección y que resulta, de manera contraintuitiva, en un monopolio. En Colombia, muchos sienten que las cuestiones de vida o muerte no pasan por el Estado y que han de atenerse a la oferta de protección de distintas agencias armadas para intentar, mediantes ensayos e interacciones con ellas y con el Estado, cierto orden social local. El artículo propone alternativas conjeturables sobre el tipo de arden que podría resultado de confrontaciones violentas no ajenas a la utopía.

  4. Superficie Específica y Estado Vital de la Materia

    Directory of Open Access Journals (Sweden)

    J. Hernando Ordoñez

    1992-03-01

    Full Text Available

    Se propone reemplazar el término de materia viva por el de estado vital de la materia por considerarlo adecuado, pues la materia es la misma, lo que cambia es su estado. Se estudia la relación entre la superficie específica y el estado vital de la materia. Constante del estado vital y el valor crítico de la superficie específica. Qué es la fuerza de inducción vital? Diferenciación funcional de las células. Cómo regula la unidad biológica su superficie específica? La materia que piensa es el fenómeno más grandioso de la creación.

    Sin entrar en disquisiciones sobre la naturaleza, manifestaciones y formas de la energía, me permito hacer unas a manera de divagaciones sobre los diferentes estados de la materia, que es una forma de la energía.

    Estados de la materia

    Sabemos que la mínima porción de la materia es el átomo, que tiene una composición compleja, que no es del caso estudiar. Los átomos pueden existir aislados y estar en lo que llamamos estado iónico. Si los átomos se juntan, forman moléculas, y su existencia constituye el estado molecular. Si las moléculas se juntan, forman complejos más grandes y tendremos las micelas, que constituyen el estado coloidal.

    Hasta aquí nuestros conocimientos nos son familiares, triviales. Pero hay un estado más complejo, en el cual entra materia en estado iónico, molecular y coloidal entrelazados entre sí, con propiedades totalmente diferentes. La materia en este estado adquiere caracteres extraordinarios tales como el de crecer, reproducirse, independizarse de las leyes físicas, puede autorregular su composición química, autorregular sus manifestaciones físicas, reaccionar ante los estímulos más variados, puede llegar hasta alturas inconcebibles integrando ideas. A este estado fue al que llamé en publicación anterior (1 estado vital, concepto que fue corroborado más ‘tarde por J.R. Brown (2 cuando me coment

  5. Superficie Específica y Estado Vital de la Materia

    OpenAIRE

    J. Hernando Ordoñez

    1992-01-01

    Se propone reemplazar el término de materia viva por el de estado vital de la materia por considerarlo adecuado, pues la materia es la misma, lo que cambia es su estado. Se estudia la relación entre la superficie específica y el estado vital de la materia. Constante del estado vital y el valor crítico de la superficie específica. Qué es la fuerza de inducción vital? Diferenciación funcional de las células. Cómo regula la unidad biológica su superficie específica? La materia que piens...

  6. Effects of age on long-term outcomes after a routine invasive or selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes: a collaborative analysis of individual data from the FRISC II - ICTUS - RITA-3 (FIR) trials.

    Science.gov (United States)

    Damman, Peter; Clayton, Tim; Wallentin, Lars; Lagerqvist, Bo; Fox, Keith A A; Hirsch, Alexander; Windhausen, Fons; Swahn, Eva; Pocock, Stuart J; Tijssen, Jan G P; de Winter, Robbert J

    2012-02-01

    To perform a patient-pooled analysis of a routine invasive versus a selective invasive strategy in elderly patients with non-ST segment elevation acute coronary syndrome. A meta-analysis was performed of patient-pooled data from the FRISC II-ICTUS-RITA-3 (FIR) studies. (Un)adjusted HRs were calculated by Cox regression, with adjustments for variables associated with age and outcomes. The main outcome was 5-year cardiovascular death or myocardial infarction (MI) following routine invasive versus selective invasive management. Regarding the 5-year composite of cardiovascular death or MI, the routine invasive strategy was associated with a lower hazard in patients aged 65-74 years (HR 0.72, 95% CI 0.58 to 0.90) and those aged ≥75 years (HR 0.71, 95% CI 0.55 to 0.91), but not in those aged RITA-3).

  7. Direito, estado e poder: poulantzas e o seu confronto com Kelsen

    Directory of Open Access Journals (Sweden)

    Luiz Eduardo Motta

    2011-02-01

    Full Text Available A Teoria do Estado, no campo da Ciência Política, viveu momentos de crise, em particular na passagem dos anos 1980 para os 1990, quando algumas correntes intelectuais apontavam que o Estado-nação e as instituições estatais deixariam de ocupar um papel central como objetos de análise. O presente artigo vai de encontro a essa posição e visa a estabelecer uma análise comparativa de dois dos mais sistemáticos autores que trataram do conceito de Estado moderno e da relação deste com o Direito moderno: Hans Kelsen e Nicos Poulantzas. O ponto de partida é a analogia estabelecida entre ambos por David Easton, em seu artigo O sistema político sitiado pelo Estado, que identifica a obra marxista de Poulantzas com a teoria sistêmica e normativa de Kelsen sobre o Direito e o Estado. De fato, paradoxalmente, Poulantzas converge em muitos aspectos com Kelsen quando critica o pensamento liberal (ao qual Kelsen é filiado e quando define que o Estado de Direito seria a antítese dos estados autoritários. Mas, a despeito dessas convergências, as diferenças entre Poulantzas e Kelsen demarcam duas formas distintas no trato teórico e político sobre os conceitos de Direito e Estado. Para Kelsen, o Estado é impermeável, não havendo contradições e fissuras internas, enquanto, para Poulantzas, o Estado é definido como um campo estratégico de lutas, permeado de micropolíticas e de contradições. O artigo é composto de uma introdução, seguida por duas seções que sistematizam as principais definições de Kelsen e Poulantzas sobre o papel do Estado e do Direito modernos, além de uma conclusão, que demarca os aspectos convergentes e divergentes entre os dois autores

  8. El Estado de Excepción en la Legislación Ecuatoriana: Caso.- Estado de Excepción en la Función Judicial

    OpenAIRE

    Carvallo Coellar, Verónica

    2013-01-01

    El Estado de Excepción como Institución Jurídica es abordado desde las definiciones doctrinarias, legales y constitucionales, una vez concluido este estudio se conoce el alcance de éste instrumento en la realidad nacional. En aquel contexto, se analiza el alcance del Decreto Ejecutivo 872 de la Declaratoria de Estado de Excepción en la Función Judicial y los efectos jurídicos que se desprendieron del mismo. En consecuencia, se determina la constitucionalidad del Decreto así como los c...

  9. La reforma del Estado de Bienestar: Derechos, deberes e igualdad de oportunidades

    Directory of Open Access Journals (Sweden)

    RICARDO MONTORO ROMERO

    1997-01-01

    Full Text Available partiendo de la situacion de crisis del estado de bienestar y basandose en los postulados defendidos por la optica de welfare mix, en este articulo se examinan la situacion de derechos y deberes propia del estado de bienestar, la necesidad de vincular la politica social con la politica economica, los limites entre la privacidad y la publicidad, y la estrecha vinculacion entre bienestar individual y bienestar publico. en este marco,

  10. Epididimite ovina por Actinobacillus seminis no Estado de Pernambuco

    Directory of Open Access Journals (Sweden)

    Mauro José Gonçalves Bezerra

    2012-05-01

    Full Text Available Relata-se a ocorrência de orquite e epididimite ovina associada ao isolamento de Actinobacillus seminis no Estado de Pernambuco. Clinicamente observou-se aumento de volume nos testículos e epidídimos, dor e aumento de temperatura local à palpação, e atrofia testicular bilateral. Após o abate observou-se a presença de conteúdo purulento no epidídimo. À microscopia dos testículos observou-se espessamento da túnica albugínea, necrose de coagulação e calcificação de túbulos seminíferos, infiltrado inflamatório com predominância de linfócitos entre túbulos seminíferos, além de mineralização incipiente de túbulos. No epidídimo observou-se intensa proliferação de tecido conjuntivo ao redor dos ductos epididimários. O diagnóstico de orquite e epididimite por Actinobacillus seminis foi confirmado pela associação dos achados clínico-patológicos, isolamento e identificação da bactéria.

  11. Confianza y cooperación en ausencia del Estado

    Directory of Open Access Journals (Sweden)

    Herreros Vázquez, Francisco

    2007-04-01

    Full Text Available It is usually considered, both in the social capital literature and the literature about trust, that interpersonal trust is a key element in social cooperation. In this article it is analyzed whether trust can foster cooperation in the absence of the State. It is concluded that in this situation it is not possible to form well-grounded expectations about other people’s trustworthiness, and, threfore, cooperation is not very likely.

    Normalmente se considera, tanto en la literatura sobre confianza como en la de capital social, que la confianza es un componente clave para la cooperación. En este artículo se analiza si la confianza puede promover la cooperación en ausencia de las instituciones del Estado. La conclusión es que en ese entorno el individuo no puede formar expectativas bien fundamentadas acerca de lo dignos de confianza que son los demás y, por ello, la cooperación es poco probable.

  12. Desarrollo convergente municipal entre estados contiguos a Nayarit y Sinaloa

    Directory of Open Access Journals (Sweden)

    Eduardo Meza-Ramos

    2010-01-01

    Full Text Available El análisis del crecimiento económico registra disparidades sectoriales que se manifiestan en el interior de los países, entre las áreas urbanas y las rurales; entre las regiones prósperas y las rezagadas. En México la política de liberalización comercial no se ha visto reflejada de manera generalizada en la riqueza de la población. Se evaluó la hipótesis de convergencia en el ámbito municipal de los estados de Chihuahua, Durango, Jalisco, Nayarit, Sinaloa, Sonora y Zacatecas; por los datos considerados en el estudio se puede argumentar la existencia de convergencia ¿ y ¿, pues en promedio, la desviación estándar en el año 1989 fue de 1.73 y disminuyó a 1.31 en 2006. La convergencia ¿ describe una relación negativa con un valor absoluto de su estadístico mayor a 2; con 95% de confianza. Cabe señalar que se cuenta con políticas sociales y sectoriales pero se carece de políticas públicas que promuevan el desarrollo regional.

  13. Educación y cultura chicana en Estados Unidos

    Directory of Open Access Journals (Sweden)

    Axel Ramírez

    2003-01-01

    Full Text Available La cultura chicana siempre ha tenido, como característica fundamental, una fuerte carga de la cultura mexicana; comparte con ésta normas y valores que tienen un carácter simbólico, de ahí que defienda su propio derecho de conservar sus raíces y de autodesignarse orgullosamente como chicanos dentro de la sociedad anglosajona contemporánea. Por razones demográficas y socioeconómicas, la cultura mexicana ha influido notoriamente en varios grupos de descendientes de mexicanos, cada vez más numerosos, que mantienen sus diferencias con la cultura mayoritaria. En vez de asimilarse al american way of life, el chicano adopta y adapta valores culturales, reforzando sus orígenes para poder sobrevivir y satisfacer necesidades mínimas. Es factible aseverar que la historia de México siempre ha estado presente en la comunidad chicana desde antes de 1848, pero sin lugar a dudas, es mucho más simple detectar que dicha historia se introduce en el pensamiento chicano a partir de la década de los años sesenta, coincidiendo con el interés de los propios anglos por conocer su cultura.

  14. México: el estado y la unidad nacional cardenista

    Directory of Open Access Journals (Sweden)

    Werner Altmann

    1983-12-01

    Full Text Available (primeiro parágrafo do artigo Durante la década de 30 importantes sectores de la economia mexicana permanecian en manos del capital extranjero (minas, petróleo, energia, transportes, por ejemplo. La destrucción de la antigua estructura agraria de poder por la Revolución Mexicana no atingió, por lo tanto en la misma medida — o solamente de forma indirecta — al capital estranjero. Además de eso, tuvo una contrapartida directa en la derrota militar de las milicias campesinas — justamente las iniciadoras del proceso revolucionario — por parte de la nueva e incipiente burguesia emergente de la Revolución. Con un operariado poco consistente y fragmentado por la existencia incluso de organizaciones paralelas el Estado pasará a jugar — sin el apoyo de capas populares de forma estructurada — un papel de creciente relevancia en el sentido de impulsionar el proceso de industrialización.

  15. y Vigilancia del Estado de México

    Directory of Open Access Journals (Sweden)

    María Soledad Gaytán Olmedo

    2005-01-01

    Full Text Available La insuficiencia de los mecanismos tradicionales de rendición de cuentas ha dado lugar a que se desarrollen diversos esquemas para asegurar que la sociedad intervenga de forma eficiente y directa en el con trol de las actividades del gobierno: Comités de Vigilancia en Bolivia, Veedurías Ciudadanas en Colombia o Contraloría Social en México, entre otros. El éxito de esos programas usualmente se refiere al número de órganos creados. Sin embargo, el presente documento tiene como objetivo establecer, desde una perspectiva cualitativa, las características principales del modelo de contraloría so cial aplicado en el Estado de México. Los puntos centrales del análisis son: quiénes participan, cómo lo hacen, qué medios se utilizan para el ejercicio del con trol so cial y dónde se aplica.

  16. O estado flow em jogadores jovens de basquetebol

    Directory of Open Access Journals (Sweden)

    Helder Zimmermann Oliveira

    2015-01-01

    Full Text Available A teoria do flow feeling auxilia na melhor compreensão do comportamento de algumas pessoas que realizam certas atividades com máximo desempenho e alto grau de motivação. Esta teoria é composta por nove dimensões/características. Com isso, o objetivo do presente estudo foi analisar qualitativamente o sentimento de flow em jogadores de basquetebol pertencentes às categorias de base. A amostra do estudo foi de 59 atletas de cinco diferentes equipes da região Sudeste, sendo duas dessas equipes consideradas de elite. Utilizou-se a entrevista semiestruturada e um questionário para coletar dados gerais sobre os atletas. Para avaliar as entrevistas utilizou-se o método de análise de conteúdo. Os resultados apontam que existem cinco dimensões mais frequentemente citadas pelos atletas (experiência autotélica; equilíbrio desafio-habilidade; objetivos claros; controle absoluto das ações e concentração intensa na tarefa. Há também outras três menos citadas (perda da noção do tempo; fusão entre ação e atenção e perda da autoconsciência. Alguns discursos apontaram para possível existência de um estado de flow da equipe.

  17. ISLAMISMOS Y ESTADO EN SUDÁN: COHESIONES Y RUPTURAS

    Directory of Open Access Journals (Sweden)

    Rafael Ortega

    2011-06-01

    Full Text Available El islamismo sudanés, surgido en la década de los cuarenta del pasado siglo, haexperimentado desde entonces una rica evolución, tanto en lo que se refiere a su estructuracomo a sus estrategias políticas. El objetivo de todo ello era contribuir a la reislamización deuna sociedad plural desde el punto de vista religioso y étnico, en función de las coyunturassocio-históricas y creando un cuerpo teórico que le ha diferenciado de otros movimientosislamistas, hasta llegar al poder en 1989 a través de un golpe de Estado. Desde entonces, elmovimiento intentó poner en pie el proyecto de “civilización islámica” teorizado por Hasanal-Turabi, pero que al pasar a la práctica se fue distorsionando. El resultado fue un régimenexcluyente que, junto a otros factores, ha provocado la secesión del sur del país.

  18. REDES SOCIALES: APROXIMACIÓN A UN ESTADO DEL ARTE

    Directory of Open Access Journals (Sweden)

    Monsalve-Gómez, Juan Carlos

    2013-06-01

    Full Text Available Este artículo presenta una revisión de estado del arte sobre las redes sociales, con una aproximación a aspectos relacionados con su impacto en el ámbito educativo, con un énfasis especial en la red social Facebook debido al crecimiento que esta ha tenido en los últimos años. El uso de las redes sociales es cada vez más difundido en el ámbito educativo y es importante, atendiendo a esta realidad, realizar estudios sobre sus posibilidades de uso, impacto y aspectos a mejorar. El texto presenta diferentes miradas de las redes sociales: como espacios de comunicación, su uso en diferentes niveles educativos, espacios de trabajo colaborativo, como apoyo a la investigación y la formación de maestros, entre otros, y realiza, al final, un análisis sobre los diferentes usos de las redes sociales en el ámbito educativo y, para terminar, un análisis sobre el uso de aplicativos educativos al interior de las redes sociales.

  19. Limitaciones del IMC como indicador exclusivo de estado nutricional

    Directory of Open Access Journals (Sweden)

    Moreno Romero, Susana

    2007-01-01

    Full Text Available El presente trabajo tiene como objetivo determinar el potencial diagnóstico y las limitaciones del uso del Índice de Masa Corporal como único indicador del estado nutricional. Para ello se analizó una muestra constituida por 2155 sujetos de ambos sexos, con edades comprendidas entre los 6 y 18 años y pertenecientes a tres poblaciones jujeñas que difieren en ubicación altitudinal y nivel socieconómico (NSE: 1. Susques, localidad rural situada a 3675 m.s.n.m; 2. Alto Comedero, barrio periférico de San Salvador de Jujuy (1250 m.s.n.m. de NSE bajo; y 3. José Hernández, muestra representativa del estrato SE elevado de la misma capital. Se tomaron las medidas directas de talla, peso, perímetro braquial y pliegues de grasa subcutánea tricipital y subescapular, entre otras. A partir de éstas, se calculó el IMC y las áreas tisulares del brazo. Se establecieron las categorías nutricionales en función de los percentilos establecidos por el NHANES I y II para la talla, IMC, área magra y grasa del brazo y pliegues tricipital y subescapular. Al comparar los resultados obtenidos para cada variable se comprueba como el uso exclusivo del IMC enmascara importantes patologías nutricionales, tanto por defecto como por exceso.

  20. La evaluación social en el Estado Liberal La evaluación social en el Estado Liberal

    Directory of Open Access Journals (Sweden)

    Leonardo Solarte Pazo

    2003-06-01

    Full Text Available This article treats on the social evaluation, particularly referred to the state interventions by means of policies, programs or public projects, approaching the public evaluation like a discipline in whom elements of diverse fields of the knowledge are conjugatedsuch as political science, the public policies and the public administration.Its intention is to make notice the existing relation between the evaluative theory andthe principles of political liberalism, as well as the potential importance of the evaluativepractice within the liberal state of well-being. In the first case some existing theoreticalnexuses between the evaluative theory and the liberal political theory are identified, inthree dimensions: axiological, epistemological and the conception of the state.In the second case, diverse forms appear to conceive the roll of the evaluation like a toolof conformation of the democracy, political and social learning, as well as mechanism toimprove the management of the government.Este artículo trata sobre la evaluación social, particularmente referida a las intervenciones estatales mediante políticas, programas o proyectos públicos, abordando la evaluación como una disciplina en la que se conjugan elementos de diversos campos del conocimiento y específicamente la ciencia política, las políticas públicas y la administración pública.Su intención es hacer notar la relación existente entre la teoría evaluativa y los principiosdel liberalismo político,   así como la potencial importancia de la práctica de la evaluacióndentro del estado liberal de bienestar. En el primer caso se plantean algunos nexos teóricosexistentes entre la teoría evaluativa y la teoría política liberal, en tres dimensiones:axiológica, epistemológica y la concepción del Estado. En el segundo caso, se presentandiversas formas de concebir el rol de la evaluación como una herramienta de conformaciónde la democracia, aprendizaje político y social