Development of a new discharge control system utilizing UNIX workstations and VME-bus systems for JT-60

Energy Technology Data Exchange (ETDEWEB)

Akasaka, Hiromi; Sueoka, Michiharu; Takano, Shoji; Totsuka, Toshiyuki; Yonekawa, Izuru; Kurihara, Kenichi; Kimura, Toyoaki [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment

2002-01-01

The JT-60 discharge control system, which had used HIDIC-80E 16 bit mini-computers and CAMAC systems since the start of JT-60 experiment in 1985, was renewed in March, 2001. The new system consists of a UNIX workstation and a VME-bus system, and features a distributed control system. The workstation performs message communication with a VME-bus system and controllers of JT-60 sub-systems and processing for discharge control because of its flexibility to construction of a new network and modifications of software. The VME-bus system performs discharge sequence control because it is suitable for fast real time control and flexible to the hardware extension. The replacement has improved the control function and reliability of the discharge control system and also has provided sufficient performance necessary for future modifications of JT-60. The new system has been running successfully since April 2001. The data acquisition speed was confirmed to be twice faster than the previous one. This report describes major functions of the discharge control system, technical ideas for developing the system and results of the initial operation in detail. (author)

HUMPF [Heterogeneous Unix Montecarlo Production Facility] users guide

International Nuclear Information System (INIS)

Cahill, P.; Edgecock, R.; Fisher, S.M.; Gee, C.N.P.; Gordon, J.C.; Kidd, T.; Leake, J.; Rigby, D.J.; Roberts, J.H.C.

1992-11-01

The Heterogenous Unix Monte Carlo Production Facility (HUMPF) simplifies the running of particle physics simulation programs on Unix workstations. Monte Carlo is the largest consumer of IBM (CPU) capacity within the Atlas centre at Rutherford Appleton Laboratory (RAL). It is likely that the future computing requirements of the LEP and HERA experiments cannot be satisfied by the IBM 3090 system. HUMPF adds extra capacity, and can be expanded with minimal effort. Monte Carlo programs are CPU-bound, and make little use of the vector or the input/output capacity of the IBM 3090. Such programs are therefore excellent candidates to use the spare capacity of powerful workstations. The main data storage is still handled centrally by the IBM 3090 and its peripherals. The HUMPF facility is suitable for any program with a similar profile. (author)

The COSY control system, a distributed realtime operating system: First practical experience at the COSY-injector

International Nuclear Information System (INIS)

Stephan, M.; Hacker, U.; Henn, K.; Richert, A.; Sobotta, K.; Weinert, A.

1991-01-01

The COSY control system is hierarchically organized with distributed intelligence and autonomous processing units for dedicated components. Data communication is performed via LAN and over a fieldbus. The hostsystems are UNIX-based, whereas the field-controllers are running a modular realtime operating-system RT/OS which has been developed at KFA. The computer-hardware consists of RISC mini computers, VME-computers in the field and G64 equipment-control-module in geographical expansion of the controller by a fieldbus based on the PDV-standard. The man-machine interface consists of X-window based work stations. On top of X-window a graphical user interface based on object oriented methods is used. A distributed realtime data base allows access to the accelerator state from every workstation. A special highlevel language debugger hosted on the UNIX based workstation and connected over LAN to the VME targets will be used. Together with the software development system for UNIX applications an uniform view of the system appears to the programmer. First practical experience at the COSY injector is presented

Benchmark Tests on the New IBM RISC System/6000 590 Workstation

Directory of Open Access Journals (Sweden)

Harvey J. Wasserman

1995-01-01

Full Text Available The results of benchmark tests on the superscalar IBM RISC System/6000 Model 590 are presented. A set of well-characterized Fortran benchmarks spanning a range of computational characteristics was used for the study. The data from the 590 system are compared with those from a single-processor CRAY C90 system as well as with other microprocessor-based systems, such as the Digital Equipment Corporation AXP 3000/500X and the Hewlett-Packard HP/735.

UWGSP6: a diagnostic radiology workstation of the future

Science.gov (United States)

Milton, Stuart W.; Han, Sang; Choi, Hyung-Sik; Kim, Yongmin

1993-06-01

The Univ. of Washington's Image Computing Systems Lab. (ICSL) has been involved in research into the development of a series of PACS workstations since the middle 1980's. The most recent research, a joint UW-IBM project, attempted to create a diagnostic radiology workstation using an IBM RISC System 6000 (RS6000) computer workstation and the X-Window system. While the results are encouraging, there are inherent limitations in the workstation hardware which prevent it from providing an acceptable level of functionality for diagnostic radiology. Realizing the RS6000 workstation's limitations, a parallel effort was initiated to design a workstation, UWGSP6 (Univ. of Washington Graphics System Processor #6), that provides the required functionality. This paper documents the design of UWGSP6, which not only addresses the requirements for a diagnostic radiology workstation in terms of display resolution, response time, etc., but also includes the processing performance necessary to support key functions needed in the implementation of algorithms for computer-aided diagnosis. The paper includes a description of the workstation architecture, and specifically its image processing subsystem. Verification of the design through hardware simulation is then discussed, and finally, performance of selected algorithms based on detailed simulation is provided.

Unix version of CALOR89 for calorimeter applications

International Nuclear Information System (INIS)

Handler, T.

1992-01-01

CALOR89 is a system of coupled Monte Carlo particle transport computer codes which has been successfully employed for the estimation of calorimeter parameters in High Energy Physics. In the past CALOR89 has been running on various IBM machines and on CRAY X-MP at Lawrence Livermore Lab. These machines had non-unix operating systems. In this report we present a UNIX version of CALOR89, which is especially suited for the UNIX work stations. Moreover CALOR89 is also been supplemented with two new program packages which makes it more user friendly. CALPREP is a program for the preparation of the input files for CALOR89 in general geometry and ANALYZ is an analysis package to extract the final results from CALOR89 relevant to calorimeters. This report also provides two script files LCALOR and PCALOR. LCALOR runs CALOR89 sequences of programs and EGS4 for a given configuration sequentially on a single processor and PCALOR concurrently on a multiprocessor unix workstation

Utilities in UNIX; Programas de Utilidad UNIX

Energy Technology Data Exchange (ETDEWEB)

Perez, L

2002-07-01

This manual goes to the users with some or much experience in the unix operating system. In such manner that they can get more efficiency using the unix of the most vendors. Include the majority of UNIX commands, shell built-in functions to create scripts, and a brief explication of the variables in several environments. In addition, other products are included, more and more integrated in the most of the unix operating systems. For example; the scanning and processing language awk, the print server LPRng, GNU utilities, batch subsystem, etc. The manual was initially based in an specific unix. But it had been written for use of the most unix that exist: Tru64 unix, aix, iris, hpux, solaris y linux. In this way, many examples in the chapter had been included. The purpose of this manual is to provide an UNIX reference for advanced users in any of the unix operating systems family. (Author)

Implementation of the ALEPH detector simulation code using UNIX with on-line graphics display

International Nuclear Information System (INIS)

Corden, M.J.; Georgiopoulos, C.H.; Mermikides, M.E.; Streets, J.

1989-01-01

GALEPH, the detector simulation program of the ALEPH detector was ported to an ETA10 running under ATandT UNIX System 5. The program on the ETA10 can be driven using standard UNIX socket connections between the ETA and a Silicon Graphics Iris-3020 workstation. The simulated data on the ETA are transferred, using the machine independent binary format EPIO, and displayed on the workstation using a locally developed software package for the visualization of the ALEPH detector. The client (Iris-3020) can also pass parameters to the server (ETA10) and thus interactively change the type of events produced using the same socket connection. (orig.)

Implementation of a control system test environment in UNIX

International Nuclear Information System (INIS)

Brittain, C.R.; Otaduy, P.J.; Rovere, L.A.

1990-01-01

This paper discusses how UNIX features such as shared memory, remote procedure calls, and signalling have been used to implement a distributed computational environment ideal for the development and testing of digital control systems. The resulting environment -based on features commonly available in commercial workstations- is flexible, allows process simulation and controller development to proceed in parallel, and provides for testing and validation in a realistic environment. In addition, the use of shared memory to exchange data allows other tasks such as user interfaces and recorders to be added without affecting the process simulation or controllers. A library of functions is presented which provides a simple interface to using the features described. These functions can be used in either C or FORTRAN programs and have been tested on a network of Sun workstations and an ENCORE parallel computer. 6 refs., 2 figs

Utilities in UNIX

International Nuclear Information System (INIS)

Perez, L.

2002-01-01

This manual goes to the users with some or much experience in the unix operating system. In such manner that they can get more efficiency using the unix of the most vendors. Include the majority of UNIX commands, shell built-in functions to create scripts, and a brief explication of the variables in several environments. In addition, other products are included, more and more integrated in the most of the unix operating systems. For example: the scanning and processing language awk, the print server LPRng, GNU Utilities, batch subsystem, etc. The manual was initially based in an specific unix. But it and been written for use of the most unix that exist: Tru64 unix, aix, iris, hpux. solaris y linux. In this way, many examples in the chapter had been included. The purpose of this manual is to provide an UNIX reference for advanced users in any of the unix operating systems family. (Author)

Nuclear plant analyzer desktop workstation

International Nuclear Information System (INIS)

Beelman, R.J.

1990-01-01

In 1983 the U.S. Nuclear Regulatory Commission (USNRC) commissioned the Idaho National Engineering Laboratory (INEL) to develop a Nuclear Plant Analyzer (NPA). The NPA was envisioned as a graphical aid to assist reactor safety analysts in comprehending the results of thermal-hydraulic code calculations. The development was to proceed in three distinct phases culminating in a desktop reactor safety workstation. The desktop NPA is now complete. The desktop NPA is a microcomputer based reactor transient simulation, visualization and analysis tool developed at INEL to assist an analyst in evaluating the transient behavior of nuclear power plants by means of graphic displays. The NPA desktop workstation integrates advanced reactor simulation codes with online computer graphics allowing reactor plant transient simulation and graphical presentation of results. The graphics software, written exclusively in ANSI standard C and FORTRAN 77 and implemented over the UNIX/X-windows operating environment, is modular and is designed to interface to the NRC's suite of advanced thermal-hydraulic codes to the extent allowed by that code. Currently, full, interactive, desktop NPA capabilities are realized only with RELAP5

A worldwide flock of Condors : load sharing among workstation clusters

NARCIS (Netherlands)

Epema, D.H.J.; Livny, M.; Dantzig, van R.; Evers, X.; Pruyne, J.

1996-01-01

Condor is a distributed batch system for sharing the workload of compute-intensive jobs in a pool of unix workstations connected by a network. In such a Condor pool, idle machines are spotted by Condor and allocated to queued jobs, thus putting otherwise unutilized capacity to efficient use. When

High-performance mass storage system for workstations

Science.gov (United States)

Chiang, T.; Tang, Y.; Gupta, L.; Cooperman, S.

1993-01-01

Reduced Instruction Set Computer (RISC) workstations and Personnel Computers (PC) are very popular tools for office automation, command and control, scientific analysis, database management, and many other applications. However, when using Input/Output (I/O) intensive applications, the RISC workstations and PC's are often overburdened with the tasks of collecting, staging, storing, and distributing data. Also, by using standard high-performance peripherals and storage devices, the I/O function can still be a common bottleneck process. Therefore, the high-performance mass storage system, developed by Loral AeroSys' Independent Research and Development (IR&D) engineers, can offload a RISC workstation of I/O related functions and provide high-performance I/O functions and external interfaces. The high-performance mass storage system has the capabilities to ingest high-speed real-time data, perform signal or image processing, and stage, archive, and distribute the data. This mass storage system uses a hierarchical storage structure, thus reducing the total data storage cost, while maintaining high-I/O performance. The high-performance mass storage system is a network of low-cost parallel processors and storage devices. The nodes in the network have special I/O functions such as: SCSI controller, Ethernet controller, gateway controller, RS232 controller, IEEE488 controller, and digital/analog converter. The nodes are interconnected through high-speed direct memory access links to form a network. The topology of the network is easily reconfigurable to maximize system throughput for various applications. This high-performance mass storage system takes advantage of a 'busless' architecture for maximum expandability. The mass storage system consists of magnetic disks, a WORM optical disk jukebox, and an 8mm helical scan tape to form a hierarchical storage structure. Commonly used files are kept in the magnetic disk for fast retrieval. The optical disks are used as archive

A PC/workstation cluster computing environment for reservoir engineering simulation applications

International Nuclear Information System (INIS)

Hermes, C.E.; Koo, J.

1995-01-01

Like the rest of the petroleum industry, Texaco has been transferring its applications and databases from mainframes to PC's and workstations. This transition has been very positive because it provides an environment for integrating applications, increases end-user productivity, and in general reduces overall computing costs. On the down side, the transition typically results in a dramatic increase in workstation purchases and raises concerns regarding the cost and effective management of computing resources in this new environment. The workstation transition also places the user in a Unix computing environment which, to say the least, can be quite frustrating to learn and to use. This paper describes the approach, philosophy, architecture, and current status of the new reservoir engineering/simulation computing environment developed at Texaco's E and P Technology Dept. (EPTD) in Houston. The environment is representative of those under development at several other large oil companies and is based on a cluster of IBM and Silicon Graphics Intl. (SGI) workstations connected by a fiber-optics communications network and engineering PC's connected to local area networks, or Ethernets. Because computing resources and software licenses are shared among a group of users, the new environment enables the company to get more out of its investments in workstation hardware and software

Making RISC.

Science.gov (United States)

Kawamata, Tomoko; Tomari, Yukihide

2010-07-01

It is well established that 20- to 30-nt small RNAs, including small interfering RNAs, microRNAs and Piwi-interacting RNAs, play crucial roles in regulating gene expression and control a surprisingly diverse array of biological processes. These small RNAs cannot work alone: they must form effector ribonucleoprotein complexes - RNA-induced silencing complexes (RISCs) - to exert their function. Thus, RISC assembly is a key process in small RNA-mediated silencing. Recent biochemical analyses of RISC assembly, together with new structural studies of Argonaute, the core protein component of RISC, suggest a revised view of how mature RISC, which contains single-stranded guide RNA, is built from small RNAs that are born double-stranded. Copyright 2010 Elsevier Ltd. All rights reserved.

A simple multiprocessor management system for event-parallel computing

International Nuclear Information System (INIS)

Bracker, S.; Gounder, K.; Hendrix, K.; Summers, D.

1996-01-01

Offline software using Transmission Control Protocol/Internet Protocol (TCP/IP) sockets to distribute particle physics events to multiple UNIX/RISC workstations is described. A modular, building block approach was taken that allowed tailoring to solve specific tasks efficiently and simply as they arose. The modest, initial cost was having to learn about sockets for interprocess communication. This multiprocessor management software has been used to control the reconstruction of eight billion raw data events from Fermilab Experiment E791

New partnerships improve eastern European training

International Nuclear Information System (INIS)

Smith, G.; Zinger, V.; Kumar, A.; Jenkins, T.

1992-01-01

In 1991, General Physics International Engineering and Simulation (GPI) won a contract for the first Western-supplied full-scope simulator and training system for a Soviet-designed RBMK. GPI was chosen by the former Soviet Ministry of Nuclear Power and Industry in open competition with other Western simulation companies. The Leningrad power plant near St Petersburg will be the host site for the simulator and training system. The total training system consists of: A full-scope, high fidelity simulator featuring: replica panels; advanced RISC technology computers; a UNIX-based, graphical X-Window, Russian text, instructor station; engineering workstations; GPI simulation software technology; and UNIX simulation development tools. Hardware and software for one analytical simulator, including instructor station, engineering workstations and several remote PC stations. Hardware and software for an interactive graphical training system. Methodology for expert system training. A psychophysiological system. Training facility equipment, including TV monitors, video players and printers. Training in hardware, software and instructor skills. This project will be carried out in co-operation with several Russian partners. Similar co-operative agreements have also been set up with Czechoslovakia and Taiwan. (author)

Experiences with installing and benchmarking SCALE 4.0 on workstations

International Nuclear Information System (INIS)

Montierth, L.M.; Briggs, J.B.

1992-01-01

The advent of economical, high-speed workstations has placed on the criticality engineer's desktop the means to perform computational analysis that was previously possible only on mainframe computers. With this capability comes the need to modify and maintain criticality codes for use on a variety of different workstations. Due to the use of nonstandard coding, compiler differences [in lieu of American National Standards Institute (ANSI) standards], and other machine idiosyncrasies, there is a definite need to systematically test and benchmark all codes ported to workstations. Once benchmarked, a user environment must be maintained to ensure that user code does not become corrupted. The goal in creating a workstation version of the criticality safety analysis sequence (CSAS) codes in SCALE 4.0 was to start with the Cray versions and change as little source code as possible yet produce as generic a code as possible. To date, this code has been ported to the IBM RISC 6000, Data General AViiON 400, Silicon Graphics 4D-35 (all using the same source code), and to the Hewlett Packard Series 700 workstations. The code is maintained under a configuration control procedure. In this paper, the authors address considerations that pertain to the installation and benchmarking of CSAS

FDDI experience at the SSCL

International Nuclear Information System (INIS)

Jaffe, M.

1993-04-01

The Physics Detector Simulation Facility (PDSF) is an assemblage of UNIX/RISC workstations and servers which use LAN networking components and standards in a unique way. The PDSF is configured using FDDI much like an internal system bus to a computer system and thus serves as the foundation for the entire PDSF system. This paper will describe the utilization of FDDI in the system, system monitoring, and the interfacing of the PDSF to the local site LAN and WAN environment

FDDI experience at the SSCL

International Nuclear Information System (INIS)

Jaffe, M.

1994-01-01

The Physics Detector Simulation Facility (PDSF) is an assemblage of UNIX/RISC workstations and servers which use LAN networking components and standards in a unique way. The PDSF is configured using FDDI much like an internal system bus to a computer system and thus serves as the foundation for the entire PDSF system. This paper will describe the utilization of FDDI in the system, system monitoring, and the interfacing of the PDSF to the local site LAN and WAN environment

Native gel analysis for RISC assembly.

Science.gov (United States)

Kawamata, Tomoko; Tomari, Yukihide

2011-01-01

Small-interfering RNAs (siRNAs) and microRNAs (miRNAs) regulate expression of their target mRNAs via the RNA-induced silencing complex (RISC). A core component of RISC is the Argonaute (Ago) protein, which dictates the RISC function. In Drosophila, miRNAs and siRNAs are generally loaded into Ago1-containing RISC (Ago1-RISC) and Ago2-containing RISC (Ago2-RISC), respectively. We developed a native agarose gel system to directly detect Ago1-RISC, Ago2-RISC, and their precursor complexes. Methods presented here will provide powerful tools to biochemically dissect the RISC assembly pathways.

Evaluation of Unix-Based Integrated Office Automation Products.

Science.gov (United States)

1994-04-01

recipient preferences of networked UNIX users. An e-mail directory contains the preferred applications (e.g., FrameMaker , Excel) for each user, and e...Future Not Available (B) FrameMaker (UNIX) E-Optional I/E-Standard Future* (B) Interleaf (UNIX) I/E-Optional I/E-Standard Future* (B) IslandWrite Not...Optional Future Not Available DXF I-Optional Future Not Available (B) EPSI I-Standard Not Available Future (B) FrameMaker (MIF) E-Optional I/E-Standard Not

[PACS-based endoscope image acquisition workstation].

Science.gov (United States)

Liu, J B; Zhuang, T G

2001-01-01

A practical PACS-based Endoscope Image Acquisition Workstation is here introduced. By a Multimedia Video Card, the endoscope video is digitized and captured dynamically or statically into computer. This workstation realizes a variety of functions such as the endoscope video's acquisition and display, as well as the editing, processing, managing, storage, printing, communication of related information. Together with other medical image workstation, it can make up the image sources of PACS for hospitals. In addition, it can also act as an independent endoscopy diagnostic system.

RISC vs. Non-RISC Schools: A Comparison of Student Proficiencies for Reading, Writing, and Mathematics

Science.gov (United States)

Haystead, Mark W.

2010-01-01

This report describes the findings for an analysis of data provided by the Re-Inventing Schools Coalition (RISC). A comparison was made between schools at seven districts that employ the RISC model and eight non-RISC districts (hereinafter referred to as RISC and non-RISC schools) on the percentages of students who scored proficient or above on…

Focusing on RISC assembly in mammalian cells.

Science.gov (United States)

Hong, Junmei; Wei, Na; Chalk, Alistair; Wang, Jue; Song, Yutong; Yi, Fan; Qiao, Ren-Ping; Sonnhammer, Erik L L; Wahlestedt, Claes; Liang, Zicai; Du, Quan

2008-04-11

RISC (RNA-induced silencing complex) is a central protein complex in RNAi, into which a siRNA strand is assembled to become effective in gene silencing. By using an in vitro RNAi reaction based on Drosophila embryo extract, an asymmetric model was recently proposed for RISC assembly of siRNA strands, suggesting that the strand that is more loosely paired at its 5' end is selectively assembled into RISC and results in target gene silencing. However, in the present study, we were unable to establish such a correlation in cell-based RNAi assays, as well as in large-scale RNAi data analyses. This suggests that the thermodynamic stability of siRNA is not a major determinant of gene silencing in mammalian cells. Further studies on fork siRNAs showed that mismatch at the 5' end of the siRNA sense strand decreased RISC assembly of the antisense strand, but surprisingly did not increase RISC assembly of the sense strand. More interestingly, measurements of melting temperature showed that the terminal stability of fork siRNAs correlated with the positions of the mismatches, but not gene silencing efficacy. In summary, our data demonstrate that there is no definite correlation between siRNA stability and gene silencing in mammalian cells, which suggests that instead of thermodynamic stability, other features of the siRNA duplex contribute to RISC assembly in RNAi.

Focusing on RISC assembly in mammalian cells

International Nuclear Information System (INIS)

Hong Junmei; Wei Na; Chalk, Alistair; Wang Jue; Song, Yutong; Yi Fan; Qiao Renping; Sonnhammer, Erik L.L.; Wahlestedt, Claes; Liang Zicai; Du, Quan

2008-01-01

RISC (RNA-induced silencing complex) is a central protein complex in RNAi, into which a siRNA strand is assembled to become effective in gene silencing. By using an in vitro RNAi reaction based on Drosophila embryo extract, an asymmetric model was recently proposed for RISC assembly of siRNA strands, suggesting that the strand that is more loosely paired at its 5' end is selectively assembled into RISC and results in target gene silencing. However, in the present study, we were unable to establish such a correlation in cell-based RNAi assays, as well as in large-scale RNAi data analyses. This suggests that the thermodynamic stability of siRNA is not a major determinant of gene silencing in mammalian cells. Further studies on fork siRNAs showed that mismatch at the 5' end of the siRNA sense strand decreased RISC assembly of the antisense strand, but surprisingly did not increase RISC assembly of the sense strand. More interestingly, measurements of melting temperature showed that the terminal stability of fork siRNAs correlated with the positions of the mismatches, but not gene silencing efficacy. In summary, our data demonstrate that there is no definite correlation between siRNA stability and gene silencing in mammalian cells, which suggests that instead of thermodynamic stability, other features of the siRNA duplex contribute to RISC assembly in RNAi

Videoconferencing using workstations in the ATLAS collaboration

International Nuclear Information System (INIS)

Onions, C.; Blokzijl, K. Bos

1994-01-01

The ATLAS collaboration consists of about 1000 physicists from close to 100 institutes around the world. This number is expected to grow over the coming years. The authors realized that they needed to do something to allow people to participate in meetings held at CERN without having to travel and hence they started a pilot project in July, 1993 to look into this. Colleagues from Nikhef already had experience of international network meetings (e.g. RIPE) using standard UNIX workstations and public domain software tools using the MBONE, hence they investigated this as a first priority

Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes

Science.gov (United States)

Kim, Kevin; Lee, Young Sik; Carthew, Richard W.

2007-01-01

In the Drosophila RNA interference (RNAi) pathway, small interfering RNAs (siRNAs) direct Argonaute2 (Ago2), an endonuclease, within the RNA-induced silencing complex (RISC) to cleave complementary mRNA targets. In vitro studies have shown that, for each siRNA duplex, RISC retains only one strand, the guide, and releases the other, the passenger, to form a holo-RISC complex. Here, we have isolated a new Ago2 mutant allele and provide, for the first time, in vivo evidence that endogenous Ago2 slicer activity is important to mount an RNAi response in Drosophila. We demonstrate in vivo that efficient removal of the passenger strand from RISC requires the cleavage activity of Ago2. We have also identified a new intermediate complex in the RISC assembly pathway, pre-RISC, in which Ago2 is stably bound to double-stranded siRNA. PMID:17123955

ATP-dependent human RISC assembly pathways.

Science.gov (United States)

Yoda, Mayuko; Kawamata, Tomoko; Paroo, Zain; Ye, Xuecheng; Iwasaki, Shintaro; Liu, Qinghua; Tomari, Yukihide

2010-01-01

The assembly of RNA-induced silencing complex (RISC) is a key process in small RNA-mediated gene silencing. In humans, small interfering RNAs (siRNAs) and microRNAs (miRNAs) are incorporated into RISCs containing the Argonaute (AGO) subfamily proteins Ago1-4. Previous studies have proposed that, unlike Drosophila melanogaster RISC assembly pathways, human RISC assembly is coupled with dicing and is independent of ATP. Here we show by careful reexamination that, in humans, RISC assembly and dicing are uncoupled, and ATP greatly facilitates RISC loading of small-RNA duplexes. Moreover, all four human AGO proteins show remarkably similar structural preferences for small-RNA duplexes: central mismatches promote RISC loading, and seed or 3'-mid (guide position 12-15) mismatches facilitate unwinding. All these features of human AGO proteins are highly reminiscent of fly Ago1 but not fly Ago2.

A versatile system for the rapid collection, handling and graphics analysis of multidimensional data

International Nuclear Information System (INIS)

O'Brien, P.M.; Moloney, G.; O'Oconnor, A.; Legge, G.J.F.

1991-01-01

The paper discusses the performances of a versatile computerized system developed at the Microanalytical Research Centre of the Melbourne University, for handling multiparameter data that may arise from a variety of experiments - nuclear, accelerator mass spectrometry, microprobe elemental analysis or 3-D microtomography. Some of the most demanding requirements arise in the application of microprobes to quantitative elemental mapping and to microtomography. A system to handle data from such experiments had been under continuous development. It has been reprogramed to run on a DG DS7540 workstation. The whole system of software has been rewritten, greatly expanded and made much more powerful and faster, by use of modern computer technology - a VME bus computer with a real-time operating system and a RISC workstation running UNIX and the X-window environment

Functional Verification of Enhanced RISC Processor

OpenAIRE

SHANKER NILANGI; SOWMYA L

2013-01-01

This paper presents design and verification of a 32-bit enhanced RISC processor core having floating point computations integrated within the core, has been designed to reduce the cost and complexity. The designed 3 stage pipelined 32-bit RISC processor is based on the ARM7 processor architecture with single precision floating point multiplier, floating point adder/subtractor for floating point operations and 32 x 32 booths multiplier added to the integer core of ARM7. The binary representati...

TAE+ 5.2 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.2 (DEC RISC ULTRIX VERSION)

Science.gov (United States)

TAE SUPPORT OFFICE

1994-01-01

programs to display and control the user interfaces. Since the WPTs access the workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides a means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System and the Open Software Foundation's Motif. The HP 9000 Series 700/800 version of TAE 5.2 requires Version 11 Release 5 of the X Window System. All other machine versions of TAE 5.2 require Version 11, Release 4 of the X Window System. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus was developed in 1989 and version 5.2 was released in 1993. TAE Plus 5.2 is available on media suitable for five different machine platforms: (1) IBM RS/6000 series workstations running AIX (.25 inch tape cartridge in UNIX tar format), (2) DEC RISC

Single-Molecule Analysis for RISC Assembly and Target Cleavage.

Science.gov (United States)

Sasaki, Hiroshi M; Tadakuma, Hisashi; Tomari, Yukihide

2018-01-01

RNA-induced silencing complex (RISC) is a small RNA-protein complex that mediates silencing of complementary target RNAs. Biochemistry has been successfully used to characterize the molecular mechanism of RISC assembly and function for nearly two decades. However, further dissection of intermediate states during the reactions has been warranted to fill in the gaps in our understanding of RNA silencing mechanisms. Single-molecule analysis with total internal reflection fluorescence (TIRF) microscopy is a powerful imaging-based approach to interrogate complex formation and dynamics at the individual molecule level with high sensitivity. Combining this technique with our recently established in vitro reconstitution system of fly Ago2-RISC, we have developed a single-molecule observation system for RISC assembly. In this chapter, we summarize the detailed protocol for single-molecule analysis of chaperone-assisted assembly of fly Ago2-RISC as well as its target cleavage reaction.

xdamp Version 4 An IDL Based Data and Image Manipulation Program

CERN Document Server

William-Ballar, P

2002-01-01

The original DAMP (W t a Manipulation Program) was written by Mark Hedemann of Sandia National Laboratories and used the CA-DISSPLA(trademark) (available from Computer Associates International, Inc., Garden City, NY) graphics package as its engine. It was used to plot, modify, and otherwise manipulate the one-dimensional data waveforms (data vs. time) from a wide variety of accelerators. With the waning of CA-DISSPLA and the increasing popularity of Unix(reg sub s ign)-based workstations, a replacement was needed. This package uses the IDL(reg sub s ign) software, available from Research Systems Incorporated, a Xerox company, in Boulder, Colorado, as the engine, and creates a set of widgets to manipulate the data in a manner similar to the original DAMP and earlier versions of xdamp. IDL is currently supported on a wide variety of Unix platforms such as IBM(reg sub s ign) workstations, Hewlett Packard workstations, SUN(reg sub s ign) workstations, Microsoft(reg sub s ign) Windows(trademark) computers, Macinto...

xdamp Version 3: An IDL reg-sign-based data and image manipulation program

International Nuclear Information System (INIS)

Ballard, W.P.

1998-05-01

The original DAMP (DAta Manipulation Program) was written by Mark Hedemann of Sandia National Laboratories and used the CA-DISSPLA trademark (available from Computer Associates International, Inc., Garden City, NY) graphics package as its engine. It was used to plot, modify, and otherwise manipulate the one-dimensional data waveforms (data vs. time) from a wide variety of accelerators. With the waning of CA-DISSPLA and the increasing popularity of Unix reg-sign-based workstations, a replacement was needed. This package uses the IDL reg-sign software, available from Research Systems Incorporated in Boulder, Colorado, as the engine, and creates a set of widgets to manipulate the data in a manner similar to the original DAMP and earlier versions of xdamp. IDL is currently supported on a wide variety of Unix platforms such as IBM reg-sign workstations, Hewlett Packard workstations, SUN reg-sign workstations, Microsoft reg-sign Windows trademark computers, Macintosh reg-sign computers and Digital Equipment Corporation VMS reg-sign and Alpha reg-sign systems. Thus, xdamp is portable across many platforms. The author has verified operation, albeit with some minor IDL bugs, on personal computers using Windows 95 and Windows NT; IBM Unix platforms; and DEC alpha and VMS systems; HP 9000/700 series workstations; and Macintosh computers, both regular and PowerPC trademark versions. Version 3 adds the capability to manipulate images to the original xdamp capabilities

Slicing-independent RISC activation requires the argonaute PAZ domain.

Science.gov (United States)

Gu, Shuo; Jin, Lan; Huang, Yong; Zhang, Feijie; Kay, Mark A

2012-08-21

Small RNAs regulate genetic networks through a ribonucleoprotein complex called the RNA-induced silencing complex (RISC), which, in mammals, contains at its center one of four Argonaute proteins (Ago1-Ago4). A key regulatory event in the RNA interference (RNAi) and microRNA (miRNA) pathways is Ago loading, wherein double-stranded small-RNA duplexes are incorporated into RISC (pre-RISC) and then become single-stranded (mature RISC), a process that is not well understood. The Agos contain an evolutionarily conserved PAZ (Piwi/Argonaute/Zwille) domain whose primary function is to bind the 3' end of small RNAs. We created multiple PAZ-domain-disrupted mutant Ago proteins and studied their biochemical properties and biological functionality in cells. We found that the PAZ domain is dispensable for Ago loading of slicing-competent RISC. In contrast, in the absence of slicer activity or slicer-substrate duplex RNAs, PAZ-disrupted Agos bound duplex small interfering RNAs, but were unable to unwind or eject the passenger strand and form functional RISC complexes. We have discovered that the highly conserved PAZ domain plays an important role in RISC activation, providing new mechanistic insights into how miRNAs regulate genes, as well as new insights for future design of miRNA- and RNAi-based therapeutics. Copyright © 2012 Elsevier Ltd. All rights reserved.

A Survey of Research in Supervisory Control and Data Acquisition (SCADA)

Science.gov (United States)

2014-09-01

RISC ) platforms running some version of UNIX.4 Around the turn of the millennium work began on applying Web technologies to SCADA systems.5–8 Lately...the 2 trend has been to move from the UNIX/ RISC system to commodity hardware and Microsoft solutions although there is some Linux,1 to move from...Control Center MTU Master Terminal Unit OS operating system PKI Public Key Infrastructure PLC Programmable Logic Controller RISC Reduced Instruction

Learning Unix for Mac OS X Tiger Unlock the Power of Unix

CERN Document Server

Taylor, Dave

2005-01-01

Thoroughly revised and updated for Mac OS X Tiger, this new edition introduces Mac users to the Terminal application and shows you how to navigate the command interface, explore hundreds of Unix applications that come with the Mac, and, most importantly, how to take advantage of both the Mac and Unix interfaces. If you want to master the command-line, this gentle guide to using Unix on Mac OS X Tiger is well worth its cover price

A unix configuration engine

International Nuclear Information System (INIS)

Burgess, M.

1994-06-01

A high level description language is presented for the purpose of automatically configuring large heterogeneous networked unix environments, based on class-oriented abstractions. The configuration engine is portable and easily extensible

xdamp Version 6 : an IDL-based data and image manipulation program.

Energy Technology Data Exchange (ETDEWEB)

Ballard, William Parker

2012-04-01

The original DAMP (DAta Manipulation Program) was written by Mark Hedemann of Sandia National Laboratories and used the CA-DISSPLA{trademark} (available from Computer Associates International, Inc., Garden City, NY) graphics package as its engine. It was used to plot, modify, and otherwise manipulate the one-dimensional data waveforms (data vs. time) from a wide variety of accelerators. With the waning of CA-DISSPLA and the increasing popularity of Unix(reg sign)-based workstations, a replacement was needed. This package uses the IDL(reg sign) software, available from Research Systems Incorporated, a Xerox company, in Boulder, Colorado, as the engine, and creates a set of widgets to manipulate the data in a manner similar to the original DAMP and earlier versions of xdamp. IDL is currently supported on a wide variety of Unix platforms such as IBM(reg sign) workstations, Hewlett Packard workstations, SUN(reg sign) workstations, Microsoft(reg sign) Windows{trademark} computers, Macintosh(reg sign) computers and Digital Equipment Corporation VMS(reg sign) and Alpha(reg sign) systems. Thus, xdamp is portable across many platforms. We have verified operation, albeit with some minor IDL bugs, on personal computers using Windows 7 and Windows Vista; Unix platforms; and Macintosh computers. Version 6 is an update that uses the IDL Virtual Machine to resolve the need for licensing IDL.

Design of a tritium decontamination workstation based on plasma cleaning

International Nuclear Information System (INIS)

Antoniazzi, A.B.; Shmayda, W.T.; Fishbien, B.F.

1993-01-01

A design for a tritium decontamination workstation based on plasma cleaning is presented. The activity of tritiated surfaces are significantly reduced through plasma-surface interactions within the workstation. Such a workstation in a tritium environment can routinely be used to decontaminate tritiated tools and components. The main advantage of such a station is the lack of low level tritiated liquid waste. Gaseous tritiated species are the waste products with can with present technology be separated and contained

RNA helicase A is not required for RISC activity.

Science.gov (United States)

Liang, Xue-Hai; Crooke, Stanley T

2013-10-01

It has been shown that siRNAs can compete with each other or with endogenous miRNAs for RISC components. This competition may complicate the interpretations of phenotypes observed through siRNA-mediated knockdown of genes, especially those genes implicated in the RISC pathway. In this study, we re-examined the function of RNA helicase A (RHA), which has been previously proposed to function in RISC loading based on siRNA-mediated knockdown studies. Here we show that reduced RISC activity or loading of siRNAs was observed only in cells depleted of RHA using siRNA, but not using RNaseH-dependent antisense oligonucleotides (ASOs), suggesting that the impaired RISC function stems from the competition between pre-existing and newly transfected siRNAs, but not from reduction of the RHA protein. This view is further supported by the findings that cells depleted of a control protein, NCL1, using siRNA, but not ASO, exhibited similar defects on the loading and activity of a subsequently transfected siRNA. Transfection of RHA or NCL1 siRNAs, but not ASOs, reduced the levels of endogenous miRNAs, suggesting a competition mechanism. As a positive control, we showed that reduction of MOV10 by either siRNA or ASO decreased siRNA activity, confirming its role in RISC function. Together, our results indicate that RHA is not required for RISC activity or loading, and suggest that proper controls are required when using siRNAs to functionalize genes to avoid competition effects. © 2013. Published by Elsevier B.V. All rights reserved.

Switching the JLab Accelerator Operations Environment from an HP-UX Unix-based to a PC/Linux-based environment

International Nuclear Information System (INIS)

Mcguckin, Theodore

2008-01-01

The Jefferson Lab Accelerator Controls Environment (ACE) was predominantly based on the HP-UX Unix platform from 1987 through the summer of 2004. During this period the Accelerator Machine Control Center (MCC) underwent a major renovation which included introducing Redhat Enterprise Linux machines, first as specialized process servers and then gradually as general login servers. As computer programs and scripts required to run the accelerator were modified, and inherent problems with the HP-UX platform compounded, more development tools became available for use with Linux and the MCC began to be converted over. In May 2008 the last HP-UX Unix login machine was removed from the MCC, leaving only a few Unix-based remote-login servers still available. This presentation will explore the process of converting an operational Control Room environment from the HP-UX to Linux platform as well as the many hurdles that had to be overcome throughout the transition period

Multimedia Synchronization and UNIX-or-If Multimedia Support is the Problem, Is UNIX the Solution?

NARCIS (Netherlands)

D.C.A. Bulterman (Dick); G. van Rossum (Guido); D.T. Winter (Dik)

1991-01-01

htmlabstractThis paper considers the role of UNIX in supporting multimedia applications. In particular, we consider the ability of the UNIX operating system (in general) and the UNIX I/O system (in particular) to support the synchronization of a number of high-bandwidth data sets that must be

Practical Unix and Internet Security

CERN Document Server

Garfinkel, Simson; Spafford, Gene

2003-01-01

When Practical Unix Security was first published more than a decade ago, it became an instant classic. Crammed with information about host security, it saved many a Unix system administrator from disaster. The second edition added much-needed Internet security coverage and doubled the size of the original volume. The third edition is a comprehensive update of this very popular book - a companion for the Unix/Linux system administrator who needs to secure his or her organization's system, networks, and web presence in an increasingly hostile world. Focusing on the four most popular Unix varia

Monte Carlo code criticality benchmark comparisons for waste packaging

International Nuclear Information System (INIS)

Alesso, H.P.; Annese, C.E.; Buck, R.M.; Pearson, J.S.; Lloyd, W.R.

1992-07-01

COG is a new point-wise Monte Carlo code being developed and tested at Lawrence Livermore National Laboratory (LLNL). It solves the Boltzmann equation for the transport of neutrons and photons. The objective of this paper is to report on COG results for criticality benchmark experiments both on a Cray mainframe and on a HP 9000 workstation. COG has been recently ported to workstations to improve its accessibility to a wider community of users. COG has some similarities to a number of other computer codes used in the shielding and criticality community. The recently introduced high performance reduced instruction set (RISC) UNIX workstations provide computational power that approach mainframes at a fraction of the cost. A version of COG is currently being developed for the Hewlett Packard 9000/730 computer with a UNIX operating system. Subsequent porting operations will move COG to SUN, DEC, and IBM workstations. In addition, a CAD system for preparation of the geometry input for COG is being developed. In July 1977, Babcock ampersand Wilcox Co. (B ampersand W) was awarded a contract to conduct a series of critical experiments that simulated close-packed storage of LWR-type fuel. These experiments provided data for benchmarking and validating calculational methods used in predicting K-effective of nuclear fuel storage in close-packed, neutron poisoned arrays. Low enriched UO2 fuel pins in water-moderated lattices in fuel storage represent a challenging criticality calculation for Monte Carlo codes particularly when the fuel pins extend out of the water. COG and KENO calculational results of these criticality benchmark experiments are presented

Multilayer checkpoints for microRNA authenticity during RISC assembly.

Science.gov (United States)

Kawamata, Tomoko; Yoda, Mayuko; Tomari, Yukihide

2011-09-01

MicroRNAs (miRNAs) function through the RNA-induced silencing complex (RISC), which contains an Argonaute (Ago) protein at the core. RISC assembly follows a two-step pathway: miRNA/miRNA* duplex loading into Ago, and separation of the two strands within Ago. Here we show that the 5' phosphate of the miRNA strand is essential for duplex loading into Ago, whereas the preferred 5' nucleotide of the miRNA strand and the base-pairing status in the seed region and the middle of the 3' region function as additive anchors to Ago. Consequently, the miRNA authenticity is inspected at multiple steps during RISC assembly.

xdamp Version 4: An IDL Based Data and Image Manipulation Program

International Nuclear Information System (INIS)

William P. Ballard

2002-01-01

The original DAMP (W t a Manipulation Program) was written by Mark Hedemann of Sandia National Laboratories and used the CA-DISSPLA(trademark) (available from Computer Associates International, Inc., Garden City, NY) graphics package as its engine. It was used to plot, modify, and otherwise manipulate the one-dimensional data waveforms (data vs. time) from a wide variety of accelerators. With the waning of CA-DISSPLA and the increasing popularity of Unix(reg s ign)-based workstations, a replacement was needed. This package uses the IDL(reg s ign) software, available from Research Systems Incorporated, a Xerox company, in Boulder, Colorado, as the engine, and creates a set of widgets to manipulate the data in a manner similar to the original DAMP and earlier versions of xdamp. IDL is currently supported on a wide variety of Unix platforms such as IBM(reg s ign) workstations, Hewlett Packard workstations, SUN(reg s ign) workstations, Microsoft(reg s ign) Windows(trademark) computers, Macintosh(reg s ign) computers and Digital Equipment Corporation VMS(reg s ign) and Alpha(reg s ign) systems. Thus, xdamp is portable across many platforms. We have verified operation, albeit with some minor IDL bugs, on personal computers using Windows 95 and Windows NT; IBM Unix platforms; DEC Alpha and VMS systems; HP 9000/700 series workstations; and Macintosh computers, both regular and PowerPC(trademark) versions. Version 4 is an update that removes some obsolete features and better supports very large arrays and Excel formatted data import

Fermi UNIX trademark environment

International Nuclear Information System (INIS)

Nicholls, J.

1991-03-01

The introduction of UNIX at Fermilab involves multiple platforms and multiple vendors. Additionally, a single user may have to use more than one platform. This heterogeneity and multiplicity makes it necessary to define a Fermilab environment for UNIX so that as much as possible the systems ''look and feel'' the same. We describe our environment, including both the commercial products and the local tools used to support it. Other products designed for the UNIX environment are also described. 19 refs

An Efficient Power Estimation Methodology for Complex RISC Processor-based Platforms

OpenAIRE

Rethinagiri , Santhosh Kumar; Ben Atitallah , Rabie; Dekeyser , Jean-Luc; Niar , Smail; Senn , Eric

2012-01-01

International audience; In this contribution, we propose an efficient power estima- tion methodology for complex RISC processor-based plat- forms. In this methodology, the Functional Level Power Analysis (FLPA) is used to set up generic power models for the different parts of the system. Then, a simulation framework based on virtual platform is developed to evalu- ate accurately the activities used in the related power mod- els. The combination of the two parts above leads to a het- erogeneou...

xdamp Version 6.100: An IDL(reg sign)-based data and image manipulation program

International Nuclear Information System (INIS)

Ballard, William Parker

2012-01-01

The original DAMP (DAta Manipulation Program) was written by Mark Hedemann of Sandia National Laboratories and used the CA-DISSPLA(trademark) (available from Computer Associates International, Inc., Garden City, NY) graphics package as its engine. It was used to plot, modify, and otherwise manipulate the one-dimensional data waveforms (data vs. time) from a wide variety of accelerators. With the waning of CA-DISSPLA and the increasing popularity of Unix(reg sign)-based workstations, a replacement was needed. This package uses the IDL(reg sign) software, available from Research Systems Incorporated, a Xerox company, in Boulder, Colorado, as the engine, and creates a set of widgets to manipulate the data in a manner similar to the original DAMP and earlier versions of xdamp. IDL is currently supported on a wide variety of Unix platforms such as IBM(reg sign) workstations, Hewlett Packard workstations, SUN(reg sign) workstations, Microsoft(reg sign) Windows(trademark) computers, Macintosh(reg sign) computers and Digital Equipment Corporation VMS(reg sign) and Alpha(reg sign) systems. Thus, xdamp is portable across many platforms. We have verified operation, albeit with some minor IDL bugs, on personal computers using Windows 7 and Windows Vista; Unix platforms; and Macintosh computers. Version 6 is an update that uses the IDL Virtual Machine to resolve the need for licensing IDL.

Mac OS X Tiger for Unix Geeks

CERN Document Server

Jepson, Brian

2005-01-01

If you're one of the many Unix developers drawn to Mac OS X for its Unix core, you'll find yourself in surprisingly unfamiliar territory. Unix and Mac OS X are kissing cousins, but there are enough pitfalls and minefields in going from one to another that even a Unix guru can stumble, and most guides to Mac OS X are written for Mac aficionados. For a Unix developer, approaching Tiger from the Mac side is a bit like learning Russian by reading the Russian side of a Russian-English dictionary. Fortunately, O'Reilly has been the Unix authority for over 25 years, and in Mac OS X Tiger for Unix Gee

Development of Novel Antisense Oligonucleotides for the Functional Regulation of RNA-Induced Silencing Complex (RISC) by Promoting the Release of microRNA from RISC.

Science.gov (United States)

Ariyoshi, Jumpei; Momokawa, Daiki; Eimori, Nao; Kobori, Akio; Murakami, Akira; Yamayoshi, Asako

2015-12-16

MicroRNAs (miRNAs) are known to be important post-transcription regulators of gene expression. Aberrant miRNA expression is associated with pathological disease processes, including carcinogenesis. Therefore, miRNAs are considered significant therapeutic targets for cancer therapy. MiRNAs do not act alone, but exhibit their functions by forming RNA-induced silencing complex (RISC). Thus, the regulation of RISC activity is a promising approach for cancer therapy. MiRNA is a core component of RISC and is an essential to RISC for recognizing target mRNA. Thereby, it is expected that development of the method to promote the release of miRNA from RISC would be an effective approach for inhibition of RISC activity. In this study, we synthesized novel peptide-conjugated oligonucleotides (RINDA-as) to promote the release of miRNA from RISC. RINDA-as showed a high rate of miRNA release from RISC and high level of inhibitory effect on RISC activity.

Clarifying mammalian RISC assembly in vitro

Directory of Open Access Journals (Sweden)

Metzler David

2011-04-01

Full Text Available Abstract Background Argonaute, the core component of the RNA induced silencing complex (RISC, binds to mature miRNAs and regulates gene expression at transcriptional or post-transcriptional level. We recently reported that Argonaute 2 (Ago2 also assembles into complexes with miRNA precursors (pre-miRNAs. These Ago2:pre-miRNA complexes are catalytically active in vitro and constitute non-canonical RISCs. Results The use of pre-miRNAs as guides by Ago2 bypasses Dicer activity and complicates in vitro RISC reconstitution. In this work, we characterized Ago2:pre-miRNA complexes and identified RNAs that are targeted by miRNAs but not their corresponding pre-miRNAs. Using these target RNAs we were able to recapitulate in vitro pre-miRNA processing and canonical RISC loading, and define the minimal factors required for these processes. Conclusions Our results indicate that Ago2 and Dicer are sufficient for processing and loading of miRNAs into RISC. Furthermore, our studies suggest that Ago2 binds primarily to the 5'- and alternatively, to the 3'-end of select pre-miRNAs.

FEAT - FAILURE ENVIRONMENT ANALYSIS TOOL (UNIX VERSION)

Science.gov (United States)

Pack, G.

1994-01-01

coprocessor or coprocessor emulator and a color monitor (or one with 256 gray scale capability). A minimum of 4Mb of free RAM is highly recommended. The UNIX version of FEAT includes both FEAT v3.6 for the Macintosh and XFEAT. XFEAT is written in C-language for Sun series workstations running SunOS, SGI workstations running IRIX, DECstations running ULTRIX, and Intergraph workstations running CLIX version 6. It requires the MIT X Window System, Version 11 Revision 4, with OSF/Motif 1.1.3, and 16Mb of RAM. The standard distribution medium for FEAT 3.6 (Macintosh version) is a set of three 3.5 inch Macintosh format diskettes. The standard distribution package for the UNIX version includes the three FEAT 3.6 Macintosh diskettes plus a .25 inch streaming magnetic tape cartridge (QIC-24) in UNIX tar format which contains XFEAT. Alternate distribution media and formats for XFEAT are available upon request. FEAT has been under development since 1990. Both FEAT v3.6 for the Macintosh and XFEAT v3.5 were released in 1993.

Energy-efficiency based classification of the manufacturing workstation

Science.gov (United States)

Frumuşanu, G.; Afteni, C.; Badea, N.; Epureanu, A.

2017-08-01

EU Directive 92/75/EC established for the first time an energy consumption labelling scheme, further implemented by several other directives. As consequence, nowadays many products (e.g. home appliances, tyres, light bulbs, houses) have an EU Energy Label when offered for sale or rent. Several energy consumption models of manufacturing equipments have been also developed. This paper proposes an energy efficiency - based classification of the manufacturing workstation, aiming to characterize its energetic behaviour. The concept of energy efficiency of the manufacturing workstation is defined. On this base, a classification methodology has been developed. It refers to specific criteria and their evaluation modalities, together to the definition & delimitation of energy efficiency classes. The energy class position is defined after the amount of energy needed by the workstation in the middle point of its operating domain, while its extension is determined by the value of the first coefficient from the Taylor series that approximates the dependence between the energy consume and the chosen parameter of the working regime. The main domain of interest for this classification looks to be the optimization of the manufacturing activities planning and programming. A case-study regarding an actual lathe classification from energy efficiency point of view, based on two different approaches (analytical and numerical) is also included.

Mac OS X for Unix Geeks (Leopard)

CERN Document Server

Rothman, Ernest E; Rosen, Rich

2009-01-01

If you've been lured to Mac OS X because of its Unix roots, this invaluable book serves as a bridge between Apple's Darwin OS and the more traditional Unix systems. The new edition offers a complete tour of Mac OS X's Unix shell for Leopard and Tiger, and helps you find the facilities that replace or correspond to standard Unix utilities. Learn how to compile code, link to libraries, and port Unix software to Mac OS X and much more with this concise guide.

SPring-8 beamline control system.

Science.gov (United States)

Ohata, T; Konishi, H; Kimura, H; Furukawa, Y; Tamasaku, K; Nakatani, T; Tanabe, T; Matsumoto, N; Ishii, M; Ishikawa, T

1998-05-01

The SPring-8 beamline control system is now taking part in the control of the insertion device (ID), front end, beam transportation channel and all interlock systems of the beamline: it will supply a highly standardized environment of apparatus control for collaborative researchers. In particular, ID operation is very important in a third-generation synchrotron light source facility. It is also very important to consider the security system because the ID is part of the storage ring and is therefore governed by the synchrotron ring control system. The progress of computer networking systems and the technology of security control require the development of a highly flexible control system. An interlock system that is independent of the control system has increased the reliability. For the beamline control system the so-called standard model concept has been adopted. VME-bus (VME) is used as the front-end control system and a UNIX workstation as the operator console. CPU boards of the VME-bus are RISC processor-based board computers operated by a LynxOS-based HP-RT real-time operating system. The workstation and the VME are linked to each other by a network, and form the distributed system. The HP 9000/700 series with HP-UX and the HP 9000/743rt series with HP-RT are used. All the controllable apparatus may be operated from any workstation.

A computer graphics pilot project - Spacecraft mission support with an interactive graphics workstation

Science.gov (United States)

Hagedorn, John; Ehrner, Marie-Jacqueline; Reese, Jodi; Chang, Kan; Tseng, Irene

1986-01-01

The NASA Computer Graphics Pilot Project was undertaken to enhance the quality control, productivity and efficiency of mission support operations at the Goddard Operations Support Computing Facility. The Project evolved into a set of demonstration programs for graphics intensive simulated control room operations, particularly in connection with the complex space missions that began in the 1980s. Complex mission mean more data. Graphic displays are a means to reduce the probabilities of operator errors. Workstations were selected with 1024 x 768 pixel color displays controlled by a custom VLSI chip coupled to an MC68010 chip running UNIX within a shell that permits operations through the medium of mouse-accessed pulldown window menus. The distributed workstations run off a host NAS 8040 computer. Applications of the system for tracking spacecraft orbits and monitoring Shuttle payload handling illustrate the system capabilities, noting the built-in capabilities of shifting the point of view and rotating and zooming in on three-dimensional views of spacecraft.

Dicer is dispensable for asymmetric RISC loading in mammals.

Science.gov (United States)

Betancur, Juan G; Tomari, Yukihide

2012-01-01

In flies, asymmetric loading of small RNA duplexes into Argonaute2-containing RNA-induced silencing complex (Ago2-RISC) requires Dicer-2/R2D2 heterodimer, which acts as a protein sensor for the thermodynamic stabilities of the ends of small RNA duplexes. However, the mechanism of small RNA asymmetry sensing in mammalian RISC assembly remains obscure. Here, we quantitatively examined RISC assembly and target silencing activity in the presence or absence of Dicer in mammals. Our data show that, unlike the well-characterized fly Ago2-RISC assembly pathway, mammalian Dicer is dispensable for asymmetric RISC loading in vivo and in vitro.

CLIPS 6.0 - C LANGUAGE INTEGRATED PRODUCTION SYSTEM, VERSION 6.0 (UNIX VERSION)

Science.gov (United States)

Donnell, B.

1994-01-01

COOL (that is, a rule can pattern match on objects created using COOL). CLIPS 6.0 provides the capability to define functions, overloaded functions, and global variables interactively. In addition, CLIPS can be embedded within procedural code, called as a subroutine, and integrated with languages such as C, FORTRAN and Ada. CLIPS can be easily extended by a user through the use of several well-defined protocols. CLIPS provides several delivery options for programs including the ability to generate stand alone executables or to load programs from text or binary files. CLIPS 6.0 provides support for the modular development and execution of knowledge bases with the defmodule construct. CLIPS modules allow a set of constructs to be grouped together such that explicit control can be maintained over restricting the access of the constructs by other modules. This type of control is similar to global and local scoping used in languages such as C or Ada. By restricting access to deftemplate and defclass constructs, modules can function as blackboards, permitting only certain facts and instances to be seen by other modules. Modules are also used by rules to provide execution control. The CRSV (Cross-Reference, Style, and Verification) utility included with previous version of CLIPS is no longer supported. The capabilities provided by this tool are now available directly within CLIPS 6.0 to aid in the development, debugging, and verification of large rule bases. COSMIC offers four distribution versions of CLIPS 6.0: UNIX (MSC-22433), VMS (MSC-22434), MACINTOSH (MSC-22429), and IBM PC (MSC-22430). Executable files, source code, utilities, documentation, and examples are included on the program media. All distribution versions include identical source code for the command line version of CLIPS 6.0. This source code should compile on any platform with an ANSI C compiler. Each distribution version of CLIPS 6.0, except that for the Macintosh platform, includes an executable for the

Development of the computer system for the JT-60 negative-ion based NBI

International Nuclear Information System (INIS)

Kawai, Mikito; Oohara, Hiroshi; Honda, Atsushi; Kuriyama, Masaaki; Aoyagi, Tetsuo.

1997-03-01

The negative-ion based NBI system (N-NBI) for JT-60 is the first NBI system using a negative-ion source in the world. The N-NBI is designed do deliver a neutral beam injection power of 10 MW at 500 keV. The computer for the N-NBI system is composed of UNIX workstations and VMEbus systems, and has the functions of ion source operation and data acquisition and processing. Since a real-time operating system compatible with the UNIX is adopted for the VMEbus systems, the software development environment both for the workstation and the VMEbus system is unified with the UNIX. The software has been developed with a priority to the software required for the verification tests which are performed in accordance with the progress of the N-NBI construction. The first beam injection with the N-NBI has been conducted in March using the newly developed software, and the deuterium neutral beam injection of 350 keV, 2.5 MW has achieved as of the end of October 1996. (author)

RISC-interacting clearing 3'- 5' exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana.

Science.gov (United States)

Zhang, Zhonghui; Hu, Fuqu; Sung, Min Woo; Shu, Chang; Castillo-González, Claudia; Koiwa, Hisashi; Tang, Guiliang; Dickman, Martin; Li, Pingwei; Zhang, Xiuren

2017-05-02

RNA-induced silencing complex (RISC) is composed of miRNAs and AGO proteins. AGOs use miRNAs as guides to slice target mRNAs to produce truncated 5' and 3' RNA fragments. The 5' cleaved RNA fragments are marked with uridylation for degradation. Here, we identified novel cofactors of Arabidopsis AGOs, named RICE1 and RICE2. RICE proteins specifically degraded single-strand (ss) RNAs in vitro; but neither miRNAs nor miRNA*s in vivo. RICE1 exhibited a DnaQ-like exonuclease fold and formed a homohexamer with the active sites located at the interfaces between RICE1 subunits. Notably, ectopic expression of catalytically-inactive RICE1 not only significantly reduced miRNA levels; but also increased 5' cleavage RISC fragments with extended uridine tails. We conclude that RICEs act to degrade uridylated 5' products of AGO cleavage to maintain functional RISC. Our study also suggests a possible link between decay of cleaved target mRNAs and miRNA stability in RISC.

Optical RISC computer

Science.gov (United States)

Guilfoyle, Peter S.; Stone, Richard V.; Hessenbruch, John M.; Zeise, Frederick F.

1993-07-01

A second generation digital optical computer (DOC II) has been developed which utilizes a RISC based operating system as its host. This 32 bit, high performance (12.8 GByte/sec), computing platform demonstrates a number of basic principals that are inherent to parallel free space optical interconnects such as speed (up to 1012 bit operations per second) and low power 1.2 fJ per bit). Although DOC II is a general purpose machine, special purpose applications have been developed and are currently being evaluated on the optical platform.

RISC assembly: Coordination between small RNAs and Argonaute proteins.

Science.gov (United States)

Kobayashi, Hotaka; Tomari, Yukihide

2016-01-01

Non-coding RNAs generally form ribonucleoprotein (RNP) complexes with their partner proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs, and PIWI-interacting RNAs, assemble with Argonaute (Ago) family proteins into the effector complex called RNA-induced silencing complex (RISC), which mediates sequence-specific target gene silencing. RISC assembly is not a simple binding between a small RNA and Ago; rather, it follows an ordered multi-step pathway that requires specific accessory factors. Some steps of RISC assembly and RISC-mediated gene silencing are dependent on or facilitated by particular intracellular platforms, suggesting their spatial regulation. In this review, we summarize the currently known mechanisms for RISC assembly of each small RNA class and propose a revised model for the role of the chaperone machinery in the duplex-initiated RISC assembly pathway. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa. Copyright © 2015 Elsevier B.V. All rights reserved.

3' fragment of miR173-programmed RISC-cleaved RNA is protected from degradation in a complex with RISC and SGS3.

Science.gov (United States)

Yoshikawa, Manabu; Iki, Taichiro; Tsutsui, Yasuhiro; Miyashita, Kyoko; Poethig, R Scott; Habu, Yoshiki; Ishikawa, Masayuki

2013-03-05

trans-acting small interfering RNAs (tasiRNAs) are plant-specific endogenous siRNAs produced via a unique pathway whose first step is the microRNA (miRNA)-programmed RNA-induced silencing complex (RISC)-mediated cleavage of tasiRNA gene (TAS) transcripts. One of the products is subsequently transformed into tasiRNAs by a pathway that requires several factors including SUPPRESSOR OF GENE SILENCING3 (SGS3) and RNA-DEPENDENT RNA POLYMERASE6. Here, using in vitro assembled ARGONAUTE (AGO)1-RISCs, we show that SGS3 is recruited onto RISCs only when they bind target RNA. Following cleavage by miRNA173 (miR173)-programmed RISC, SGS3 was found in complexes containing cleaved TAS2 RNA and RISC. The 3' cleavage fragment (the source of tasiRNAs) was protected from degradation in this complex. Depletion of SGS3 did not affect TAS2 RNA cleavage by miR173-programmed RISC, but did affect the stability of the 3' cleavage fragment. When the 3' nucleotide of 22-nt miR173 was deleted or the corresponding nucleotide in TAS2 RNA was mutated, the complex was not observed and the 3' cleavage fragment was degraded. Importantly, these changes in miR173 or TAS2 RNA are known to lead to a loss of tasiRNA production in vivo. These results suggest that (i) SGS3 associates with AGO1-RISC via the double-stranded RNA formed by the 3'-terminal nucleotides of 22-nt miR173 and corresponding target RNA, which probably protrudes from the AGO1-RISC molecular surface, (ii) SGS3 protects the 3' cleavage fragment of TAS2 RNA from degradation, and (iii) the observed SGS3-dependent stabilization of the 3' fragment of TAS2 RNA is key to tasiRNA production.

A novel rotometer based on a RISC microcontroller.

Science.gov (United States)

Heredia-López, F J; Bata-García, J L; Alvarez-Cervera, F J; Góngora-Alfaro, J L

2002-08-01

A new, low-cost rotometer, based on a reduced instruction set computer (RISC) microcontroller, is presented. Like earlier devices, it counts the number and direction of full turns for predetermined time periods during the evaluation of turning behavior induced by drug administration in rats. The present stand-alone system includes a nonvolatile memory for long-term data storage and a serial port for data transmission. It also contains a display for monitoring the experiments and has battery backup to avoid interruptions owing to power failures. A high correlation was found (r > .988, p < 2 x 10(-14)) between the counts of the rotometer and those of two trained observers. The system reflects quantitative differences in turning behavior owing to pharmacological manipulations. It provides the most common counting parameters and is inexpensive, flexible, highly reliable, and completely portable (weight including batteries, 159 g).

In vitro reconstitution of chaperone-mediated human RISC assembly.

Science.gov (United States)

Naruse, Ken; Matsuura-Suzuki, Eriko; Watanabe, Mariko; Iwasaki, Shintaro; Tomari, Yukihide

2018-01-01

To silence target mRNAs, small RNAs and Argonaute (Ago) proteins need to be assembled into RNA-induced silencing complexes (RISCs). Although the assembly of Drosophila melanogaster RISC was recently reconstituted by Ago2, the Dicer-2/R2D2 heterodimer, and five chaperone proteins, the absence of a reconstitution system for mammalian RISC assembly has posed analytical challenges. Here we describe reconstitution of human RISC assembly using Ago2 and five recombinant chaperone proteins: Hsp90β, Hsc70, Hop, Dnaja2, and p23. Our data show that ATP hydrolysis by both Hsp90β and Hsc70 is required for RISC assembly of small RNA duplexes but not for that of single-stranded RNAs. The reconstitution system lays the groundwork for further studies of small RNA-mediated gene silencing in mammals. © 2018 Naruse et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

A scoring system for ascertainment of incident stroke; the Risk Index Score (RISc).

Science.gov (United States)

Kass-Hout, T A; Moyé, L A; Smith, M A; Morgenstern, L B

2006-01-01

The main objective of this study was to develop and validate a computer-based statistical algorithm that could be translated into a simple scoring system in order to ascertain incident stroke cases using hospital admission medical records data. The Risk Index Score (RISc) algorithm was developed using data collected prospectively by the Brain Attack Surveillance in Corpus Christi (BASIC) project, 2000. The validity of RISc was evaluated by estimating the concordance of scoring system stroke ascertainment to stroke ascertainment by physician and/or abstractor review of hospital admission records. RISc was developed on 1718 randomly selected patients (training set) and then statistically validated on an independent sample of 858 patients (validation set). A multivariable logistic model was used to develop RISc and subsequently evaluated by goodness-of-fit and receiver operating characteristic (ROC) analyses. The higher the value of RISc, the higher the patient's risk of potential stroke. The study showed RISc was well calibrated and discriminated those who had potential stroke from those that did not on initial screening. In this study we developed and validated a rapid, easy, efficient, and accurate method to ascertain incident stroke cases from routine hospital admission records for epidemiologic investigations. Validation of this scoring system was achieved statistically; however, clinical validation in a community hospital setting is warranted.

The Newcastle connection: A software subsystem for constructing distributed UNIX systems

International Nuclear Information System (INIS)

Randell, B.

1985-01-01

The Newcastle connection is a software subsystem that can be added to each of a set of physically interconnected UNIX or UNIX look-alike systems, so as to construct a distributed system which is functionally indistinguishable at both the user and the program level from a conventional single-processor UNIX system. The techniques used are applicable to a variety and multiplicity of both local and wide area networks, and enable all issues of inter-processor communication, network protocols, etc., to be hidden. A brief account is given of experience with such distributed systems, the first of which was constructed in 1982 using a set of PDP11s running UNIX Version 7, and connected by a Cambridge Ring - since this date the Connection has been used to construct distributed systems based on various other computers and versions of UNIX, both at Newcastle and elsewhere. The final sections compare our scheme to various precursor schemes and discuss its potential relevance to other operating systems. (orig.)

NET remote workstation

International Nuclear Information System (INIS)

Leinemann, K.

1990-10-01

The goal of this NET study was to define the functionality of a remote handling workstation and its hardware and software architecture. The remote handling workstation has to fulfill two basic functions: (1) to provide the man-machine interface (MMI), that means the interface to the control system of the maintenance equipment and to the working environment (telepresence) and (2) to provide high level (task level) supporting functions (software tools) during the maintenance work and in the preparation phase. Concerning the man-machine interface, an important module of the remote handling workstation besides the standard components of man-machine interfacing is a module for graphical scene presentation supplementing viewing by TV. The technique of integrated viewing is well known from JET BOOM and TARM control using the GBsim and KISMET software. For integration of equipment dependent MMI functions the remote handling workstation provides a special software module interface. Task level support of the operator is based on (1) spatial (geometric/kinematic) models, (2) remote handling procedure models, and (3) functional models of the equipment. These models and the related simulation modules are used for planning, programming, execution monitoring, and training. The workstation provides an intelligent handbook guiding the operator through planned procedures illustrated by animated graphical sequences. For unplanned situations decision aids are available. A central point of the architectural design was to guarantee a high flexibility with respect to hardware and software. Therefore the remote handling workstation is designed as an open system based on widely accepted standards allowing the stepwise integration of the various modules starting with the basic MMI and the spatial simulation as standard components. (orig./HP) [de

The equipment access software for a distributed UNIX-based accelerator control system

International Nuclear Information System (INIS)

Trofimov, Nikolai; Zelepoukine, Serguei; Zharkov, Eugeny; Charrue, Pierre; Gareyte, Claire; Poirier, Herve

1994-01-01

This paper presents a generic equipment access software package for a distributed control system using computers with UNIX or UNIX-like operating systems. The package consists of three main components, an application Equipment Access Library, Message Handler and Equipment Data Base. An application task, which may run in any computer in the network, sends requests to access equipment through Equipment Library calls. The basic request is in the form Equipment-Action-Data and is routed via a remote procedure call to the computer to which the given equipment is connected. In this computer the request is received by the Message Handler. According to the type of the equipment connection, the Message Handler either passes the request to the specific process software in the same computer or forwards it to a lower level network of equipment controllers using MIL1553B, GPIB, RS232 or BITBUS communication. The answer is then returned to the calling application. Descriptive information required for request routing and processing is stored in the real-time Equipment Data Base. The package has been written to be portable and is currently available on DEC Ultrix, LynxOS, HPUX, XENIX, OS-9 and Apollo domain. ((orig.))

De predictieve validiteit van de Recidive Inschattingsschalen (RISc)

NARCIS (Netherlands)

Knaap, L.M. van der; Alberda, D.L.

2009-01-01

Om inzichten te krijgen in criminogene factoren van delinquenten is het screeningsinstrument 'Recidive Inschattingsschalen' (RISc) ontwikkeld. De betrouwbaarheid en validiteit van dit instrument zijn al onderzocht en positief bevonden. Dit onderzoek gaat na of de RISc geschikt is als

The Fermi Unix Environment - Dealing with Adolescence

Science.gov (United States)

Pordes, Ruth; Nicholls, Judy; Wicks, Matt

Fermilab's Computing Division started early in the definition implemention and promulgation of a common environment for Users across the Laboratory's UNIX platforms and installations. Based on our experience over nearly five years, we discuss the status of the effort ongoing developments and needs, some analysis of where we could have done better, and identify future directions to allow us to provide better and more complete service to our customers. In particular, with the power of the new PCs making enthusiastic converts of physicists to the pc world, we are faced with the challenge of expanding the paradigm to non-UNIX platforms in a uniform and consistent way.

Unix Application Migration Guide

CERN Document Server

Microsoft. Redmond

2003-01-01

Drawing on the experience of Microsoft consultants working in the field, as well as external organizations that have migrated from UNIX to Microsoft® Windows®, this guide offers practical, prescriptive guidance on the issues you are likely to face when porting existing UNIX applications to the Windows operating system environment. Senior IT decision makers, network managers, and operations managers will get real-world guidance and best practices on planning and implementation issues to understand the different methods through which migration or co-existence can be accomplished. Also detailing

EGS4 benchmark program

International Nuclear Information System (INIS)

Yasu, Y.; Hirayama, H.; Namito, Y.; Yashiro, S.

1995-01-01

This paper proposes EGS4 Benchmark Suite which consists of three programs called UCSAMPL4, UCSAMPL4I and XYZDOS. This paper also evaluates optimization methods of recent RISC/UNIX systems, such as IBM, HP, DEC, Hitachi and Fujitsu, for the benchmark suite. When particular compiler option and math library were included in the evaluation process, system performed significantly better. Observed performance of some of the RISC/UNIX systems were beyond some so-called Mainframes of IBM, Hitachi or Fujitsu. The computer performance of EGS4 Code System on an HP9000/735 (99MHz) was defined to be the unit of EGS4 Unit. The EGS4 Benchmark Suite also run on various PCs such as Pentiums, i486 and DEC alpha and so forth. The performance of recent fast PCs reaches that of recent RISC/UNIX systems. The benchmark programs have been evaluated with correlation of industry benchmark programs, namely, SPECmark. (author)

RISC processing in Fastbus

International Nuclear Information System (INIS)

Atiya, M.; Haggerty, J.; Ng, C.; Sambamurti, A.; Strzelinski, R.

1990-01-01

This paper reports on the designed, construction and testing microprocessor based controller for data acquisition and analysis conforming to the IEEE-960 Fastbus standard. The controller uses the RISC AM29000 processor and the Am29027 floating point co-processor. The module functions as a Fastbus slave and is used for analysis and filtering of digitially sampled waveforms acquired in a large system of high performance transient digitizers (over 200 channels, each sampling at 500 MHz. with 8 bits of dynamic range). With modifications the module can operate as a Fastbus master

Anatomy of RISC: how do small RNAs and chaperones activate Argonaute proteins?

Science.gov (United States)

Nakanishi, Kotaro

2016-09-01

RNA silencing is a eukaryote-specific phenomenon in which microRNAs and small interfering RNAs degrade messenger RNAs containing a complementary sequence. To this end, these small RNAs need to be loaded onto an Argonaute protein (AGO protein) to form the effector complex referred to as RNA-induced silencing complex (RISC). RISC assembly undergoes multiple and sequential steps with the aid of Hsc70/Hsp90 chaperone machinery. The molecular mechanisms for this assembly process remain unclear, despite their significance for the development of gene silencing techniques and RNA interference-based therapeutics. This review dissects the currently available structures of AGO proteins and proposes models and hypotheses for RISC assembly, covering the conformation of unloaded AGO proteins, the chaperone-assisted duplex loading, and the slicer-dependent and slicer-independent duplex separation. The differences in the properties of RISC between prokaryotes and eukaryotes will also be clarified. WIREs RNA 2016, 7:637-660. doi: 10.1002/wrna.1356 For further resources related to this article, please visit the WIREs website. © 2016 The Authors. WIREs RNA published by Wiley Periodicals, Inc.

UNIX by examples

International Nuclear Information System (INIS)

Nee, F.

1990-10-01

This report discusses the following topics on UNIX basis programming: file structure; frequently used commands/utilities; control structures used in shell script; c-shell programming; and bourne shell programming

3′ fragment of miR173-programmed RISC-cleaved RNA is protected from degradation in a complex with RISC and SGS3

Science.gov (United States)

Yoshikawa, Manabu; Iki, Taichiro; Tsutsui, Yasuhiro; Miyashita, Kyoko; Poethig, R. Scott; Habu, Yoshiki; Ishikawa, Masayuki

2013-01-01

trans-acting small interfering RNAs (tasiRNAs) are plant-specific endogenous siRNAs produced via a unique pathway whose first step is the microRNA (miRNA)-programmed RNA-induced silencing complex (RISC)–mediated cleavage of tasiRNA gene (TAS) transcripts. One of the products is subsequently transformed into tasiRNAs by a pathway that requires several factors including SUPPRESSOR OF GENE SILENCING3 (SGS3) and RNA-DEPENDENT RNA POLYMERASE6. Here, using in vitro assembled ARGONAUTE (AGO)1–RISCs, we show that SGS3 is recruited onto RISCs only when they bind target RNA. Following cleavage by miRNA173 (miR173)-programmed RISC, SGS3 was found in complexes containing cleaved TAS2 RNA and RISC. The 3′ cleavage fragment (the source of tasiRNAs) was protected from degradation in this complex. Depletion of SGS3 did not affect TAS2 RNA cleavage by miR173-programmed RISC, but did affect the stability of the 3′ cleavage fragment. When the 3′ nucleotide of 22-nt miR173 was deleted or the corresponding nucleotide in TAS2 RNA was mutated, the complex was not observed and the 3′ cleavage fragment was degraded. Importantly, these changes in miR173 or TAS2 RNA are known to lead to a loss of tasiRNA production in vivo. These results suggest that (i) SGS3 associates with AGO1–RISC via the double-stranded RNA formed by the 3′-terminal nucleotides of 22-nt miR173 and corresponding target RNA, which probably protrudes from the AGO1–RISC molecular surface, (ii) SGS3 protects the 3′ cleavage fragment of TAS2 RNA from degradation, and (iii) the observed SGS3-dependent stabilization of the 3′ fragment of TAS2 RNA is key to tasiRNA production. PMID:23417299

RISC-interacting clearing 3’- 5’ exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana

Science.gov (United States)

Zhang, Zhonghui; Hu, Fuqu; Sung, Min Woo; Shu, Chang; Castillo-González, Claudia; Koiwa, Hisashi; Tang, Guiliang; Dickman, Martin; Li, Pingwei; Zhang, Xiuren

2017-01-01

RNA-induced silencing complex (RISC) is composed of miRNAs and AGO proteins. AGOs use miRNAs as guides to slice target mRNAs to produce truncated 5' and 3' RNA fragments. The 5' cleaved RNA fragments are marked with uridylation for degradation. Here, we identified novel cofactors of Arabidopsis AGOs, named RICE1 and RICE2. RICE proteins specifically degraded single-strand (ss) RNAs in vitro; but neither miRNAs nor miRNA*s in vivo. RICE1 exhibited a DnaQ-like exonuclease fold and formed a homohexamer with the active sites located at the interfaces between RICE1 subunits. Notably, ectopic expression of catalytically-inactive RICE1 not only significantly reduced miRNA levels; but also increased 5' cleavage RISC fragments with extended uridine tails. We conclude that RICEs act to degrade uridylated 5’ products of AGO cleavage to maintain functional RISC. Our study also suggests a possible link between decay of cleaved target mRNAs and miRNA stability in RISC. DOI: http://dx.doi.org/10.7554/eLife.24466.001 PMID:28463111

A fastbus master based on a risc microprocessor

International Nuclear Information System (INIS)

Cerrito, L.; Chorowicz, V.; Lebbolo, H.; Vallereau, A.

1990-01-01

SISIFUS is a general purpose Fastbus Master and Slave able to perform any operation on both Fastbus segments. Master operations are directed either by the processor or by two fast sequencers. A Block Mover function is implemented allowing direct data block transfers between two Slaves. SISIFUS uses the AM 29000 RISC microprocessor which can execute every assembler instruction in 40ns. The on-board monitor/debugger allows programs to be written in assembler from a terminal connected to the module or written in C and cross compiled on a host computer (PC)

Parallelising a molecular dynamics algorithm on a multi-processor workstation

Science.gov (United States)

Müller-Plathe, Florian

1990-12-01

The Verlet neighbour-list algorithm is parallelised for a multi-processor Hewlett-Packard/Apollo DN10000 workstation. The implementation makes use of memory shared between the processors. It is a genuine master-slave approach by which most of the computational tasks are kept in the master process and the slaves are only called to do part of the nonbonded forces calculation. The implementation features elements of both fine-grain and coarse-grain parallelism. Apart from three calls to library routines, two of which are standard UNIX calls, and two machine-specific language extensions, the whole code is written in standard Fortran 77. Hence, it may be expected that this parallelisation concept can be transfered in parts or as a whole to other multi-processor shared-memory computers. The parallel code is routinely used in production work.

An antiviral RISC isolated from Tobacco rattle virus-infected plants.

Science.gov (United States)

Ciomperlik, Jessica J; Omarov, Rustem T; Scholthof, Herman B

2011-03-30

The RNAi model predicts that during antiviral defense a RNA-induced silencing complex (RISC) is programmed with viral short-interfering RNAs (siRNAs) to target the cognate viral RNA for degradation. We show that infection of Nicotiana benthamiana with Tobacco rattle virus (TRV) activates an antiviral nuclease that specifically cleaves TRV RNA in vitro. In agreement with known RISC properties, the nuclease activity was inhibited by NaCl and EDTA and stimulated by divalent metal cations; a novel property was its preferential targeting of elongated RNA molecules. Intriguingly, the specificity of the TRV RISC could be reprogrammed by exogenous addition of RNA (containing siRNAs) from plants infected with an unrelated virus, resulting in a newly acquired ability of RISC to target this heterologous genome in vitro. Evidently the virus-specific nuclease complex from N. benthamiana represents a genuine RISC that functions as a readily employable and reprogrammable antiviral defense unit. Copyright © 2011 Elsevier Inc. All rights reserved.

Unix Domain Sockets Applied in Android Malware Should Not Be Ignored

Directory of Open Access Journals (Sweden)

Xu Jiang

2018-03-01

Full Text Available Increasingly, malicious Android apps use various methods to steal private user data without their knowledge. Detecting the leakage of private data is the focus of mobile information security. An initial investigation found that none of the existing security analysis systems can track the flow of information through Unix domain sockets to detect the leakage of private data through such sockets, which can result in zero-day exploits in the information security field. In this paper, we conduct the first systematic study on Unix domain sockets as applied in Android apps. Then, we identify scenarios in which such apps can leak private data through Unix domain sockets, which the existing dynamic taint analysis systems do not catch. Based on these insights, we propose and implement JDroid, a taint analysis system that can track information flows through Unix domain sockets effectively to detect such privacy leaks.

AGO/RISC-mediated antiviral RNA silencing in a plant in vitro system.

Science.gov (United States)

Schuck, Jana; Gursinsky, Torsten; Pantaleo, Vitantonio; Burgyán, Jozsef; Behrens, Sven-Erik

2013-05-01

AGO/RISC-mediated antiviral RNA silencing, an important component of the plant's immune response against RNA virus infections, was recapitulated in vitro. Cytoplasmic extracts of tobacco protoplasts were applied that supported Tombusvirus RNA replication, as well as the formation of RNA-induced silencing complexes (RISC) that could be functionally reconstituted with various plant ARGONAUTE (AGO) proteins. For example, when RISC containing AGO1, 2, 3 or 5 were programmed with exogenous siRNAs that specifically targeted the viral RNA, endonucleolytic cleavages occurred and viral replication was inhibited. Antiviral RNA silencing was disabled by the viral silencing suppressor p19 when this was present early during RISC formation. Notably, with replicating viral RNA, only (+)RNA molecules were accessible to RISC, whereas (-)RNA replication intermediates were not. The vulnerability of viral RNAs to RISC activity also depended on the RNA structure of the target sequence. This was most evident when we characterized viral siRNAs (vsiRNAs) that were particularly effective in silencing with AGO1- or AGO2/RISC. These vsiRNAs targeted similar sites, suggesting that accessible parts of the viral (+)RNA may be collectively attacked by different AGO/RISC. The in vitro system was, hence, established as a valuable tool to define and characterize individual molecular determinants of antiviral RNA silencing.

Structural determinants of miRNAs for RISC loading and slicer-independent unwinding.

Science.gov (United States)

Kawamata, Tomoko; Seitz, Hervé; Tomari, Yukihide

2009-09-01

MicroRNAs (miRNAs) regulate expression of their target mRNAs through the RNA-induced silencing complex (RISC), which contains an Argonaute (Ago) family protein as a core component. In Drosophila melanogaster, miRNAs are generally sorted into Ago1-containing RISC (Ago1-RISC). We established a native gel system that can biochemically dissect the Ago1-RISC assembly pathway. We found that miRNA-miRNA* duplexes are loaded into Ago1 as double-stranded RNAs in an ATP-dependent fashion. In contrast, unexpectedly, unwinding of miRNA-miRNA* duplexes is a passive process that does not require ATP or slicer activity of Ago1. Central mismatches direct miRNA-miRNA* duplexes into pre-Ago1-RISC, whereas mismatches in the seed or guide strand positions 12-15 promote conversion of pre-Ago1-RISC into mature Ago1-RISC. Our findings show that unwinding of miRNAs is a precise mirror-image process of target recognition, and both processes reflect the unique geometry of RNAs in Ago proteins.

Distributed computing at the SSCL

International Nuclear Information System (INIS)

Cormell, L.; White, R.

1993-05-01

The rapid increase in the availability of high performance, cost- effective RISC/UNIX workstations has been both a blessing and a curse. The blessing of having extremely powerful computing engines available on the desk top is well-known to many users. The user has tremendous freedom, flexibility, and control of his environment. That freedom can, however, become the curse of distributed computing. The user must become a system manager to some extent, he must worry about backups, maintenance, upgrades, etc. Traditionally these activities have been the responsibility of a central computing group. The central computing group, however, may find that it can no linger provide all of the traditional services. With the plethora of workstations now found on so many desktops throughout the entire campus or lab, the central computing group may be swamped by support requests. This talk will address several of these computer support and management issues by discussing the approach taken at the Superconducting Super Collider Laboratory. In addition, a brief review of the future directions of commercial products for distributed computing and management will be given

Distributed computing at the SSCL

International Nuclear Information System (INIS)

Cormell, L.R.; White, R.C.

1994-01-01

The rapid increase in the availability of high performance, cost-effective RISC/UNIX workstations has been both a blessing and a curse. The blessing of having extremely powerful computing engines available on the desk top is well-known to many users. The user has tremendous freedom, flexibility, and control of his environment. That freedom can, however, become the curse of distributed computing. The user must become a system manager to some extent, he must worry about backups, maintenance, upgrades, etc. Traditionally these activities have been the responsibility of central computing group. The central computing group, however, may find that it can no longer provide all of the traditional services. With the plethora of workstations now found on so many desktops throughout the entire campus or lab, the central computing group may be swamped by support requests. This talk will address several of these computer support and management issues by discussing the approach taken at the Superconducting Super Collider Laboratory (SSCL). In addition, a brief review of the future directions of commercial products for distributed computing and management will be given

Coping with distributed computing

International Nuclear Information System (INIS)

Cormell, L.

1992-09-01

The rapid increase in the availability of high performance, cost-effective RISC/UNIX workstations has been both a blessing and a curse. The blessing of having extremely powerful computing engines available on the desk top is well-known to many users. The user has tremendous freedom, flexibility, and control of his environment. That freedom can, however, become the curse of distributed computing. The user must become a system manager to some extent, he must worry about backups, maintenance, upgrades, etc. Traditionally these activities have been the responsibility of a central computing group. The central computing group, however, may find that it can no longer provide all of the traditional services. With the plethora of workstations now found on so many desktops throughout the entire campus or lab, the central computing group may be swamped by support requests. This talk will address several of these computer support and management issues by providing some examples of the approaches taken at various HEP institutions. In addition, a brief review of commercial directions or products for distributed computing and management will be given

UNIX-based operating systems robustness evaluation

Science.gov (United States)

Chang, Yu-Ming

1996-01-01

Robust operating systems are required for reliable computing. Techniques for robustness evaluation of operating systems not only enhance the understanding of the reliability of computer systems, but also provide valuable feed- back to system designers. This thesis presents results from robustness evaluation experiments on five UNIX-based operating systems, which include Digital Equipment's OSF/l, Hewlett Packard's HP-UX, Sun Microsystems' Solaris and SunOS, and Silicon Graphics' IRIX. Three sets of experiments were performed. The methodology for evaluation tested (1) the exception handling mechanism, (2) system resource management, and (3) system capacity under high workload stress. An exception generator was used to evaluate the exception handling mechanism of the operating systems. Results included exit status of the exception generator and the system state. Resource management techniques used by individual operating systems were tested using programs designed to usurp system resources such as physical memory and process slots. Finally, the workload stress testing evaluated the effect of the workload on system performance by running a synthetic workload and recording the response time of local and remote user requests. Moderate to severe performance degradations were observed on the systems under stress.

Cyclophilin 40 facilitates HSP90-mediated RISC assembly in plants.

Science.gov (United States)

Iki, Taichiro; Yoshikawa, Manabu; Meshi, Tetsuo; Ishikawa, Masayuki

2012-01-18

Posttranscriptional gene silencing is mediated by RNA-induced silencing complexes (RISCs) that contain AGO proteins and single-stranded small RNAs. The assembly of plant AGO1-containing RISCs depends on the molecular chaperone HSP90. Here, we demonstrate that cyclophilin 40 (CYP40), protein phosphatase 5 (PP5), and several other proteins with the tetratricopeptide repeat (TPR) domain associates with AGO1 in an HSP90-dependent manner in extracts of evacuolated tobacco protoplasts (BYL). Intriguingly, CYP40, but not the other TPR proteins, could form a complex with small RNA duplex-bound AGO1. Moreover, CYP40 that was synthesized by in-vitro translation using BYL uniquely facilitated binding of small RNA duplexes to AGO1, and as a result, increased the amount of mature RISCs that could cleave target RNAs. CYP40 was not contained in mature RISCs, indicating that the association is transient. Addition of PP5 or cyclophilin-binding drug cyclosporine A prevented the association of endogenous CYP40 with HSP90-AGO1 complex and inhibited RISC assembly. These results suggest that a complex of AGO1, HSP90, CYP40, and a small RNA duplex is a key intermediate of RISC assembly in plants.

From a UNIX to a PC Based SCADA System

CERN Document Server

Momal, F

1999-01-01

In order to facilitate the development of supervisory applications involved in slow process control (such as cryogenic control), the LHC/IAS Group (Equipment Controls Group) opted, a few years ago, for an industrial SCADA package which runs on UNIXÒ platforms. However, to reduce costs and following market trends, it has been decided to move over to a PC-based package. Several processes relating to the testing of the prototypes of the LHC magnets are already controlled in this way. However, it was still necessary to provide all the services previously available to the users, for example, data archiving in central databases, real-time access through the Web, automatic GSM calls, etc. This paper presents the advantages and drawbacks of a PC-based package versus a Unix-based system. It also lists the criteria used in the market survey to arrive at the final selection, as well as, the overall architecture, highlighting the developments needed to integrate the package into the global computing environment.

The effect of dynamic workstations on the performance of various computer and office-based tasks

NARCIS (Netherlands)

Burford, E.M.; Botter, J.; Commissaris, D.; Könemann, R.; Hiemstra-Van Mastrigt, S.; Ellegast, R.P.

2013-01-01

The effect of different workstations, conventional and dynamic, on different types of performance measures for several different office and computer based task was investigated in this research paper. The two dynamic workstations assessed were the Lifespan Treadmill Desk and the RightAngle

Proposta e simulação de uma arquitetura RISC

OpenAIRE

Fredy Joao Valente

1991-01-01

RISC - Uma nova tendência em arquitetura de computadores. Este trabalho apresenta um estudo de como surgiu esta nova arquitetura, e suas características básicas, que a diferencia das arquiteturas convencionais. Uma proposta de microprocessador RISC é apresentada, com sua rota de dados completamente detalhada. Um simulador para arquitetura RISC foi então construído, para se testar este microprocessador. Para validar o simulador, que é a idéia principal deste trabalho, e para se avaliar a arqui...

The Radiation, Interplanetary Shocks, and Coronal Sources (RISCS) Toolset

Science.gov (United States)

Zank, G. P.; Spann, James F.

2014-01-01

The goal of this project is to serve the needs of space system designers and operators by developing an interplanetary radiation environment model within 10 AU:Radiation, Interplanetary Shocks, and Coronal Sources (RISCS) toolset: (1) The RISCS toolset will provide specific reference environments for space system designers and nowcasting and forecasting capabilities for space system operators; (2) We envision the RISCS toolset providing the spatial and temporal radiation environment external to the Earth's (and other planets') magnetosphere, as well as possessing the modularity to integrate separate applications (apps) that can map to specific magnetosphere locations and/or perform the subsequent radiation transport and dosimetry for a specific target.

Protection against hostile algorithms in UNIX software

Science.gov (United States)

Radatti, Peter V.

1996-03-01

Protection against hostile algorithms contained in Unix software is a growing concern without easy answers. Traditional methods used against similar attacks in other operating system environments such as MS-DOS or Macintosh are insufficient in the more complex environment provided by Unix. Additionally, Unix provides a special and significant problem in this regard due to its open and heterogeneous nature. These problems are expected to become both more common and pronounced as 32 bit multiprocess network operating systems become popular. Therefore, the problems experienced today are a good indicator of the problems and the solutions that will be experienced in the future, no matter which operating system becomes predominate.

48 CFR 1523.7002 - Waivers.

Science.gov (United States)

2010-10-01

... ENVIRONMENTAL, CONSERVATION, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy-Efficient Computer Equipment 1523.7002 Waivers. (a) There are several types of computer equipment which technically fall under the...; including bridges and routers; (2) UNIX RISC based processors with their high-end monitors; (3) Large LAN...

A UNIX-based prototype biomedical virtual image processor

International Nuclear Information System (INIS)

Fahy, J.B.; Kim, Y.

1987-01-01

The authors have developed a multiprocess virtual image processor for the IBM PC/AT, in order to maximize image processing software portability for biomedical applications. An interprocess communication scheme, based on two-way metacode exchange, has been developed and verified for this purpose. Application programs call a device-independent image processing library, which transfers commands over a shared data bridge to one or more Autonomous Virtual Image Processors (AVIP). Each AVIP runs as a separate process in the UNIX operating system, and implements the device-independent functions on the image processor to which it corresponds. Application programs can control multiple image processors at a time, change the image processor configuration used at any time, and are completely portable among image processors for which an AVIP has been implemented. Run-time speeds have been found to be acceptable for higher level functions, although rather slow for lower level functions, owing to the overhead associated with sending commands and data over the shared data bridge

UNIX code management and distribution

International Nuclear Information System (INIS)

Hung, T.; Kunz, P.F.

1992-09-01

We describe a code management and distribution system based on tools freely available for the UNIX systems. At the master site, version control is managed with CVS, which is a layer on top of RCS, and distribution is done via NFS mounted file systems. At remote sites, small modifications to CVS provide for interactive transactions with the CVS system at the master site such that remote developers are true peers in the code development process

The Linux operating system: An introduction

Science.gov (United States)

Bokhari, Shahid H.

1995-01-01

Linux is a Unix-like operating system for Intel 386/486/Pentium based IBM-PCs and compatibles. The kernel of this operating system was written from scratch by Linus Torvalds and, although copyrighted by the author, may be freely distributed. A world-wide group has collaborated in developing Linux on the Internet. Linux can run the powerful set of compilers and programming tools of the Free Software Foundation, and XFree86, a port of the X Window System from MIT. Most capabilities associated with high performance workstations, such as networking, shared file systems, electronic mail, TeX, LaTeX, etc. are freely available for Linux. It can thus transform cheap IBM-PC compatible machines into Unix workstations with considerable capabilities. The author explains how Linux may be obtained, installed and networked. He also describes some interesting applications for Linux that are freely available. The enormous consumer market for IBM-PC compatible machines continually drives down prices of CPU chips, memory, hard disks, CDROMs, etc. Linux can convert such machines into powerful workstations that can be used for teaching, research and software development. For professionals who use Unix based workstations at work, Linux permits virtually identical working environments on their personal home machines. For cost conscious educational institutions Linux can create world-class computing environments from cheap, easily maintained, PC clones. Finally, for university students, it provides an essentially cost-free path away from DOS into the world of Unix and X Windows.

An in vitro reprogrammable antiviral RISC with size-preferential ribonuclease activity.

Science.gov (United States)

Omarov, Rustem T; Ciomperlik, Jessica; Scholthof, Herman B

2016-03-01

Infection of Nicotiana benthamiana plants with Tomato bushy stunt virus (TBSV) mutants compromised for silencing suppression induces formation of an antiviral RISC (vRISC) that can be isolated using chromatography procedures. The isolated vRISC sequence-specifically degrades TBSV RNA in vitro, its activity can be down-regulated by removing siRNAs, and re-stimulated by exogenous supply of siRNAs. vRISC is most effective at hydrolyzing the ~4.8kb genomic RNA, but less so for a ~2.2kb TBSV subgenomic mRNA (sgRNA1), while the 3' co-terminal sgRNA2 of ~0.9kb appears insensitive to vRISC cleavage. Moreover, experiments with in vitro generated 5' co-terminal viral transcripts show that RNAs of ~2.7kb are efficiently cleaved while those of ~1.1kb or shorter are unaffected. The isolated antiviral ribonuclease complex fails to degrade ~0.4kb defective interfering RNAs (DIs) in vitro, agreeing with findings that in plants DIs are not targeted by silencing. Copyright © 2016. Published by Elsevier Inc.

gLExec: gluing grid computing to the Unix world

Science.gov (United States)

Groep, D.; Koeroo, O.; Venekamp, G.

2008-07-01

The majority of compute resources in todays scientific grids are based on Unix and Unix-like operating systems. In this world, user and user-group management are based around the concepts of a numeric 'user ID' and 'group ID' that are local to the resource. In contrast, grid concepts of user and group management are centered around globally assigned identifiers and VO membership, structures that are independent of any specific resource. At the fabric boundary, these 'grid identities' have to be translated to Unix user IDs. New job submission methodologies, such as job-execution web services, community-deployed local schedulers, and the late binding of user jobs in a grid-wide overlay network of 'pilot jobs', push this fabric boundary ever further down into the resource. gLExec, a light-weight (and thereby auditable) credential mapping and authorization system, addresses these issues. It can be run both on fabric boundary, as part of an execution web service, and on the worker node in a late-binding scenario. In this contribution we describe the rationale for gLExec, how it interacts with the site authorization and credential mapping frameworks such as LCAS, LCMAPS and GUMS, and how it can be used to improve site control and traceability in a pilot-job system.

gLExec: gluing grid computing to the Unix world

International Nuclear Information System (INIS)

Groep, D; Koeroo, O; Venekamp, G

2008-01-01

The majority of compute resources in todays scientific grids are based on Unix and Unix-like operating systems. In this world, user and user-group management are based around the concepts of a numeric 'user ID' and 'group ID' that are local to the resource. In contrast, grid concepts of user and group management are centered around globally assigned identifiers and VO membership, structures that are independent of any specific resource. At the fabric boundary, these 'grid identities' have to be translated to Unix user IDs. New job submission methodologies, such as job-execution web services, community-deployed local schedulers, and the late binding of user jobs in a grid-wide overlay network of 'pilot jobs', push this fabric boundary ever further down into the resource. gLExec, a light-weight (and thereby auditable) credential mapping and authorization system, addresses these issues. It can be run both on fabric boundary, as part of an execution web service, and on the worker node in a late-binding scenario. In this contribution we describe the rationale for gLExec, how it interacts with the site authorization and credential mapping frameworks such as LCAS, LCMAPS and GUMS, and how it can be used to improve site control and traceability in a pilot-job system

Advanced Satellite Workstation - An integrated workstation environment for operational support of satellite system planning and analysis

Science.gov (United States)

Hamilton, Marvin J.; Sutton, Stewart A.

A prototype integrated environment, the Advanced Satellite Workstation (ASW), which was developed and delivered for evaluation and operator feedback in an operational satellite control center, is described. The current ASW hardware consists of a Sun Workstation and Macintosh II Workstation connected via an ethernet Network Hardware and Software, Laser Disk System, Optical Storage System, and Telemetry Data File Interface. The central objective of ASW is to provide an intelligent decision support and training environment for operator/analysis of complex systems such as satellites. Compared to the many recent workstation implementations that incorporate graphical telemetry displays and expert systems, ASW provides a considerably broader look at intelligent, integrated environments for decision support, based on the premise that the central features of such an environment are intelligent data access and integrated toolsets.

The concepts and functions of a FEM workstation

International Nuclear Information System (INIS)

Brown, R.R.; Gloudeman, J.F.

1982-01-01

Recent advances in microprocessor-based computer hardware and associated software provide a basis for the development of a FEM workstation. The key requirements for such a workstation are reviewed and the recent hardware and software developments are discussed that make such a workstation both technically and economically feasible at this time. (orig.)

16-Bit RISC Processor Design for Convolution Application

OpenAIRE

Anand Nandakumar Shardul

2013-01-01

In this project, we propose a 16-bit non-pipelined RISC processor, which is used for signal processing applications. The processor consists of the blocks, namely, program counter, clock control unit, ALU, IDU and registers. Advantageous architectural modifications have been made in the incremented circuit used in program counter and carry select adder unit of the ALU in the RISC CPU core. Furthermore, a high speed and low power modified modifies multiplier has been designed and introduced in ...

Differential RISC association of endogenous human microRNAs predicts their inhibitory potential.

Science.gov (United States)

Flores, Omar; Kennedy, Edward M; Skalsky, Rebecca L; Cullen, Bryan R

2014-04-01

It has previously been assumed that the generally high stability of microRNAs (miRNAs) reflects their tight association with Argonaute (Ago) proteins, essential components of the RNA-induced silencing complex (RISC). However, recent data have suggested that the majority of mature miRNAs are not, in fact, Ago associated. Here, we demonstrate that endogenous human miRNAs vary widely, by >100-fold, in their level of RISC association and show that the level of Ago binding is a better indicator of inhibitory potential than is the total level of miRNA expression. While miRNAs of closely similar sequence showed comparable levels of RISC association in the same cell line, these varied between different cell types. Moreover, the level of RISC association could be modulated by overexpression of complementary target mRNAs. Together, these data indicate that the level of RISC association of a given endogenous miRNA is regulated by the available RNA targetome and predicts miRNA function.

RISC RNA sequencing for context-specific identification of in vivo microRNA targets.

Science.gov (United States)

Matkovich, Scot J; Van Booven, Derek J; Eschenbacher, William H; Dorn, Gerald W

2011-01-07

MicroRNAs (miRs) are expanding our understanding of cardiac disease and have the potential to transform cardiovascular therapeutics. One miR can target hundreds of individual mRNAs, but existing methodologies are not sufficient to accurately and comprehensively identify these mRNA targets in vivo. To develop methods permitting identification of in vivo miR targets in an unbiased manner, using massively parallel sequencing of mouse cardiac transcriptomes in combination with sequencing of mRNA associated with mouse cardiac RNA-induced silencing complexes (RISCs). We optimized techniques for expression profiling small amounts of RNA without introducing amplification bias and applied this to anti-Argonaute 2 immunoprecipitated RISCs (RISC-Seq) from mouse hearts. By comparing RNA-sequencing results of cardiac RISC and transcriptome from the same individual hearts, we defined 1645 mRNAs consistently targeted to mouse cardiac RISCs. We used this approach in hearts overexpressing miRs from Myh6 promoter-driven precursors (programmed RISC-Seq) to identify 209 in vivo targets of miR-133a and 81 in vivo targets of miR-499. Consistent with the fact that miR-133a and miR-499 have widely differing "seed" sequences and belong to different miR families, only 6 targets were common to miR-133a- and miR-499-programmed hearts. RISC-sequencing is a highly sensitive method for general RISC profiling and individual miR target identification in biological context and is applicable to any tissue and any disease state.

Development and upgrade of new real time processor in JT-60 data processing system

International Nuclear Information System (INIS)

Sakata, Shinya; Koiwa, Motonao; Matsuda, Toshiaki; Aoyagi, Tetsuo

2000-07-01

At the beginning of JT-60 experiments, the real time processor (RTP) in the data processing system was mainly constructed by PANAFACOM U-1500. As the computer became superannuated, however, it gradually became difficult to maintain both hardware and software. A performance of a recent UNIX workstation has been remarkably progressed. The UNIX workstation has a large flexibility for user application programs, an easiness for maintenance of the hardware and an ability of expansion to peripheral devices. Therefore, the RTP system is newly reconstructed by using the UNIX workstation. This report describes the overview, the basic design and the recent upgrade on the RTP in the data processing system. (author)

Understanding Unix/Linux programming a guide to theory and practice

CERN Document Server

Molay, Bruce

2003-01-01

This book explains in a clear and coherent manner how Unix works, how to understand existing Unix programs, and how to design and create new Unix programs. The book is organized by subsystem, each presented in visual terms and explained using vivid metaphors. It breaks the information into manageable parts that can be presented, explained, and mastered. By using case studies and an extremely reader-friendly manner to illustrate complex ideas and concepts, the book covers the basics of systems programming, users, files and manuals, how to read a directory, using 1S, writing PWD, studying STTY, writing a video game, studying SH, environment and shell variables, I/O redirection and pipes, servers and sockets, writing a web server, license servers, and concurrent functions. For Unix system administrators and programmers, network programmers, and others who have used other operating systems and need to learn Unix programming to expand their skill sets.

Real-time UNIX in HEP data acquisition

International Nuclear Information System (INIS)

Buono, S.; Gaponenko, I.; Jones, R.; Mapelli, L.; Mornacchi, G.; Prigent, D.; Sanchez-Corral, E.; Skiadelli, M.; Toppers, A.; Duval, P.Y.; Ferrato, D.; Le Van Suu, A.; Qian, Z.; Rondot, C.; Ambrosini, G.; Fumagalli, G.; Aguer, M.; Huet, M.

1994-01-01

Today's experimentation in high energy physics is characterized by an increasing need for sensitivity to rare phenomena and complex physics signatures, which require the use of huge and sophisticated detectors and consequently a high performance readout and data acquisition. Multi-level triggering, hierarchical data collection and an always increasing amount of processing power, distributed throughout the data acquisition layers, will impose a number of features on the software environment, especially the need for a high level of standardization. Real-time UNIX seems, today, the best solution for the platform independence, operating system interface standards and real-time features necessary for data acquisition in HEP experiments. We present the results of the evaluation, in a realistic application environment, of a Real-Time UNIX operating system: the EP/LX real-time UNIX system. ((orig.))

Evaluation of PC-based diagnostic radiology workstations

International Nuclear Information System (INIS)

Pollack, T.; Brueggenwerth, G.; Kaulfuss, K.; Niederlag, W.

2000-01-01

Material and Methods: During February 1999 and September 1999 medical users at the hospital Dresden-Friedrichstadt Germany had tested 7 types of radiology diagnostic workstations. Two types of test methods were used: In test type 1 ergonomic and handling functions were evaluated impartial according to 78 selected user requirements. In test type 2 radiologists and radiographers (3+4) performed 23 work flow steps with a subjectively evaluation. Results: By using a progressive rating no product could fully meet the user requirements. As a result of the summary evaluation for test 1 and test 2 the following compliance rating was calculated for the different products: Rad Works (66%), Magic View (63%), ID-Report (58%), Impax 3000 (53%), Medical Workstation (52%), Pathspeed (46%) and Autorad (39%). (orig.) [de

Unix Security Cookbook

Science.gov (United States)

Rehan, S. C.

This document has been written to help Site Managers secure their Unix hosts from being compromised by hackers. I have given brief introductions to the security tools along with downloading, configuring and running information. I have also included a section on my recommendations for installing these security tools starting from an absolute minimum security requirement.

C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation.

Science.gov (United States)

Liu, Ying; Ye, Xuecheng; Jiang, Feng; Liang, Chunyang; Chen, Dongmei; Peng, Junmin; Kinch, Lisa N; Grishin, Nick V; Liu, Qinghua

2009-08-07

The catalytic engine of RNA interference (RNAi) is the RNA-induced silencing complex (RISC), wherein the endoribonuclease Argonaute and single-stranded small interfering RNA (siRNA) direct target mRNA cleavage. We reconstituted long double-stranded RNA- and duplex siRNA-initiated RISC activities with the use of recombinant Drosophila Dicer-2, R2D2, and Ago2 proteins. We used this core reconstitution system to purify an RNAi regulator that we term C3PO (component 3 promoter of RISC), a complex of Translin and Trax. C3PO is a Mg2+-dependent endoribonuclease that promotes RISC activation by removing siRNA passenger strand cleavage products. These studies establish an in vitro RNAi reconstitution system and identify C3PO as a key activator of the core RNAi machinery.

Autoantigen La promotes efficient RNAi, antiviral response, and transposon silencing by facilitating multiple-turnover RISC catalysis.

Science.gov (United States)

Liu, Ying; Tan, Huiling; Tian, Hui; Liang, Chunyang; Chen, She; Liu, Qinghua

2011-11-04

The effector of RNA interference (RNAi) is the RNA-induced silencing complex (RISC). C3PO promotes the activation of RISC by degrading the Argonaute2 (Ago2)-nicked passenger strand of duplex siRNA. Active RISC is a multiple-turnover enzyme that uses the guide strand of siRNA to direct the Ago2-mediated sequence-specific cleavage of complementary mRNA. How this effector step of RNAi is regulated is currently unknown. Here, we used the human Ago2 minimal RISC system to purify Sjögren's syndrome antigen B (SSB)/autoantigen La as an activator of the RISC-mediated mRNA cleavage activity. Our reconstitution studies showed that La could promote multiple-turnover RISC catalysis by facilitating the release of cleaved mRNA from RISC. Moreover, we demonstrated that La was required for efficient RNAi, antiviral defense, and transposon silencing in vivo. Taken together, the findings of C3PO and La reveal a general concept that regulatory factors are required to remove Ago2-cleaved products to assemble or restore active RISC. Copyright © 2011 Elsevier Inc. All rights reserved.

A study on the effectiveness of lockup-free caches for a Reduced Instruction Set Computer (RISC) processor

OpenAIRE

Tharpe, Leonard.

1992-01-01

Approved for public release; distribution is unlimited This thesis presents a simulation and analysis of the Reduced Instruction Set Computer (RISC) architecture and the effects on RISC performance of a lockup-free cache interface. RISC architectures achieve high performance by having a small, but sufficient, instruction set with most instructions executing in one clock cycle. Current RISC performance range from 1.5 to 2.0 CPI. The goal of RISC is to attain a CPI of 1.0. The major hind...

VMware workstation

CERN Document Server

van Vugt, Sander

2013-01-01

This book is a practical, step-by-step guide to creating and managing virtual machines using VMware Workstation.VMware Workstation: No Experience Necessary is for developers as well as system administrators who want to efficiently set up a test environment .You should have basic networking knowledge, and prior experience with Virtual Machines and VMware Player would be beneficial

The DISTO data acquisition system at SATURNE

International Nuclear Information System (INIS)

Balestra, F.; Bedfer, Y.; Bertini, R.

1998-01-01

The DISTO collaboration has built a large-acceptance magnetic spectrometer designed to provide broad kinematic coverage of multiparticle final states produced in pp scattering. The spectrometer has been installed in the polarized proton beam of the Saturne accelerator in Saclay to study polarization observables in the rvec pp → pK + rvec Y (Y = Λ, Σ 0 or Y * ) reaction and vector meson production (ψ, ω and ρ) in pp collisions. The data acquisition system is based on a VME 68030 CPU running the OS/9 operating system, housed in a single VME crate together with the CAMAC interface, the triple port ECL memories, and four RISC R3000 CPU. The digitization of signals from the detectors is made by PCOS III and FERA front-end electronics. Data of several events belonging to a single Saturne extraction are stored in VME triple-port ECL memories using a hardwired fast sequencer. The buffer, optionally filtered by the RISC R3000 CPU, is recorded on a DLT cassette by DAQ CPU using the on-board SCSI interface during the acceleration cycle. Two UNIX workstations are connected to the VME CPUs through a fast parallel bus and the Local Area Network. They analyze a subset of events for on-line monitoring. The data acquisition system is able to read and record 3,500 ev/burst in the present configuration with a dead time of 15%

Emulating conventional operator interfaces on window-based workstations

International Nuclear Information System (INIS)

Carr, G.P.

1990-01-01

This paper explores an approach to support the LAMPF and PSR control systems on VAX/VMS workstations using DECwindows and VI Corporation Data Views as the operator interface. The PSR control system was recently turned over to MP division and the two control-system staffs were merged into one group. One of the goals of this new group is to develop a common workstation-based operator console and interface which can be used in a single control room controlling both the linac and proton storage ring. The new console operator interface will need a high-level graphics toolkit for its implementation. During the conversion to the new consoles it will also probably be necessary to write a package to emulate the current operator interfaces at the software level. This paper describes a project to evaluate the appropriateness of VI Corporation's Data Views graphics package for use in the LAMPF control-system environment by using it to write an emulation of the LAMPF touch-panel interface to a large LAMPF control-system application program. A secondary objective of this project was to explore any productivity increases that might be realized by using an object-oriented graphics package and graphics editor. (orig.)

A Real-Time Image Acquisition And Processing System For A RISC-Based Microcomputer

Science.gov (United States)

Luckman, Adrian J.; Allinson, Nigel M.

1989-03-01

A low cost image acquisition and processing system has been developed for the Acorn Archimedes microcomputer. Using a Reduced Instruction Set Computer (RISC) architecture, the ARM (Acorn Risc Machine) processor provides instruction speeds suitable for image processing applications. The associated improvement in data transfer rate has allowed real-time video image acquisition without the need for frame-store memory external to the microcomputer. The system is comprised of real-time video digitising hardware which interfaces directly to the Archimedes memory, and software to provide an integrated image acquisition and processing environment. The hardware can digitise a video signal at up to 640 samples per video line with programmable parameters such as sampling rate and gain. Software support includes a work environment for image capture and processing with pixel, neighbourhood and global operators. A friendly user interface is provided with the help of the Archimedes Operating System WIMP (Windows, Icons, Mouse and Pointer) Manager. Windows provide a convenient way of handling images on the screen and program control is directed mostly by pop-up menus.

Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma.

Science.gov (United States)

Yoo, Byoung Kwon; Santhekadur, Prasanna K; Gredler, Rachel; Chen, Dong; Emdad, Luni; Bhutia, Sujit; Pannell, Lewis; Fisher, Paul B; Sarkar, Devanand

2011-05-01

There is virtually no effective treatment for advanced hepatocellular carcinoma (HCC) and novel targets need to be identified to develop effective treatment. We recently documented that the oncogene Astrocyte elevated gene-1 (AEG-1) plays a seminal role in hepatocarcinogenesis. Employing yeast two-hybrid assay and coimmunoprecipitation followed by mass spectrometry, we identified staphylococcal nuclease domain containing 1 (SND1), a nuclease in the RNA-induced silencing complex (RISC) facilitating RNAi-mediated gene silencing, as an AEG-1 interacting protein. Coimmunoprecipitation and colocalization studies confirmed that AEG-1 is also a component of RISC and both AEG-1 and SND1 are required for optimum RISC activity facilitating small interfering RNA (siRNA) and micro RNA (miRNA)-mediated silencing of luciferase reporter gene. In 109 human HCC samples SND1 was overexpressed in ≈74% cases compared to normal liver. Correspondingly, significantly higher RISC activity was observed in human HCC cells compared to immortal normal hepatocytes. Increased RISC activity, conferred by AEG-1 or SND1, resulted in increased degradation of tumor suppressor messenger RNAs (mRNAs) that are target of oncomiRs. Inhibition of enzymatic activity of SND1 significantly inhibited proliferation of human HCC cells. As a corollary, stable overexpression of SND1 augmented and siRNA-mediated inhibition of SND1 abrogated growth of human HCC cells in vitro and in vivo, thus revealing a potential role of SND1 in hepatocarcinogenesis. We unravel a novel mechanism that overexpression of AEG-1 and SND1 leading to increased RISC activity might contribute to hepatocarcinogenesis. Targeted inhibition of SND1 enzymatic activity might be developed as an effective therapy for HCC. Copyright © 2011 American Association for the Study of Liver Diseases.

A comparison between digital images viewed on a picture archiving and communication system diagnostic workstation and on a PC-based remote viewing system by emergency physicians.

Science.gov (United States)

Parasyn, A; Hanson, R M; Peat, J K; De Silva, M

1998-02-01

Picture Archiving and Communication Systems (PACS) make possible the viewing of radiographic images on computer workstations located where clinical care is delivered. By the nature of their work this feature is particularly useful for emergency physicians who view radiographic studies for information and use them to explain results to patients and their families. However, the high cost of PACS diagnostic workstations with fuller functionality places limits on the number of and therefore the accessibility to workstations in the emergency department. This study was undertaken to establish how well less expensive personal computer-based workstations would work to support these needs of emergency physicians. The study compared the outcome of observations by 5 emergency physicians on a series of radiographic studies containing subtle abnormalities displayed on both a PACS diagnostic workstation and on a PC-based workstation. The 73 digitized radiographic studies were randomly arranged on both types of workstation over four separate viewing sessions for each emergency physician. There was no statistical difference between a PACS diagnostic workstation and a PC-based workstation in this trial. The mean correct ratings were 59% on the PACS diagnostic workstations and 61% on the PC-based workstations. These findings also emphasize the need for prompt reporting by a radiologist.

Script-viruses Attacks on UNIX OS

Directory of Open Access Journals (Sweden)

D. M. Mikhaylov

2010-06-01

Full Text Available In this article attacks on UNIX OS are considered. Currently antivirus developers are concentrated on protecting systems from viruses that are most common and attack popular operating systems. If the system or its components are not often attacked then the antivirus products are not protecting these components as it is not profitable. The same situation is with script-viruses for UNIX OS as most experts consider that it is impossible for such viruses to get enough rights to attack. Nevertheless the main conclusion of this article is the fact that such viruses can be very powerful and can attack systems and get enough rights.

A workstation based spectrometry application for ECR ion source [Paper No.: G5

International Nuclear Information System (INIS)

Suresh Babu, R.M.; . PS Div.)

1993-01-01

A program for an Electron Cyclotron Resonance (ECR) Ion Source beam diagnostics application in a X-Windows/Motif based workstation environment is discussed. The application program controls the hardware and acquires data via a front end computer across a local area network. The data is subsequently processed for displaying on the workstation console. The timing for data acquisition and control is determined by the particle source timing. The user interface has been implemented using the Motif widget set and the actions have been implemented through call back routines. The equipment interface is through a set of database driven calls across the network. (author). 7 refs., 1 fig

Integrated telemedicine workstation for intercontinental grand rounds

Science.gov (United States)

Willis, Charles E.; Leckie, Robert G.; Brink, Linda; Goeringer, Fred

1995-04-01

The Telemedicine Spacebridge to Moscow was a series of intercontinental sessions sponsored jointly by NASA and the Moscow Academy of Medicine. To improve the quality of medical images presented, the MDIS Project developed a workstation for acquisition, storage, and interactive display of radiology and pathology images. The workstation was based on a Macintosh IIfx platform with a laser digitizer for radiographs and video capture capability for microscope images. Images were transmitted via the Russian Lyoutch Satellite which had only a single video channel available and no high speed data channels. Two workstations were configured -- one for use at the Uniformed Services University of Health Sciences in Bethesda, MD. and the other for use at the Hospital of the Interior in Moscow, Russia. The two workstations were used may times during 16 sessions. As clinicians used the systems, we modified the original configuration to improve interactive use. This project demonstrated that numerous acquisition and output devices could be brought together in a single interactive workstation. The video images were satisfactory for remote consultation in a grand rounds format.

A general model of concurrency and its implementation as many-core dynamic RISC processors

NARCIS (Netherlands)

Bernard, T.; Bousias, K.; Guang, L.; Jesshope, C.R.; Lankamp, M.; van Tol, M.W.; Zhang, L.

2008-01-01

This paper presents a concurrent execution model and its micro-architecture based on in-order RISC processors, which schedules instructions from large pools of contextualised threads. The model admits a strategy for programming chip multiprocessors using parallelising compilers based on existing

Argonaute pull-down and RISC analysis using 2'-O-methylated oligonucleotides affinity matrices.

Science.gov (United States)

Jannot, Guillaume; Vasquez-Rifo, Alejandro; Simard, Martin J

2011-01-01

During the last decade, several novel small non-coding RNA pathways have been unveiled, which reach out to many biological processes. Common to all these pathways is the binding of a small RNA molecule to a protein member of the Argonaute family, which forms a minimal core complex called the RNA-induced silencing complex or RISC. The RISC targets mRNAs in a sequence-specific manner, either to induce mRNA cleavage through the intrinsic activity of the Argonaute protein or to abrogate protein synthesis by a mechanism that is still under investigation. We describe here, in details, a method for the affinity chromatography of the let-7 RISC starting from extracts of the nematode Caenorhabditis elegans. Our method exploits the sequence specificity of the RISC and makes use of biotinylated and 2'-O-methylated oligonucleotides to trap and pull-down small RNAs and their associated proteins. Importantly, this technique may easily be adapted to target other small RNAs expressed in different cell types or model organisms. This method provides a useful strategy to identify the proteins associated with the RISC, and hence gain insight in the functions of small RNAs.

The RISC-spectrometer experiment

International Nuclear Information System (INIS)

Pinter, Gy.

1981-01-01

The RISC (Relativistic Ionising Streamer Chamber) spectrometer (situated at Protvino, joining the accelerator) is discussed, and the experiment carried out in international cooperation is presented. The beam monitor, the trigger system and the control and data recording system as well as the streamer spark chamber are detailed (the latter is the largest of our time). Examples of the main experiments as well as the work carried out in Budapest are discussed briefly. (Sz.J.)

VMEbus based computer and real-time UNIX as infrastructure of DAQ

International Nuclear Information System (INIS)

Yasu, Y.; Fujii, H.; Nomachi, M.; Kodama, H.; Inoue, E.; Tajima, Y.; Takeuchi, Y.; Shimizu, Y.

1994-01-01

This paper describes what the authors have constructed as the infrastructure of data acquisition system (DAQ). The paper reports recent developments concerned with HP VME board computer with LynxOS (HP742rt/HP-RT) and Alpha/OSF1 with VMEbus adapter. The paper also reports current status of developing a Benchmark Suite for Data Acquisition (DAQBENCH) for measuring not only the performance of VME/CAMAC access but also that of the context switching, the inter-process communications and so on, for various computers including Workstation-based systems and VME board computers

The Resilient Schools Consortium (RiSC): Linking Climate Literacy, Resilience Thinking and Service Learning

Science.gov (United States)

Branco, B. F.; Fano, E.; Adams, J.; Shon, L.; Zimmermann, A.; Sioux, H.; Gillis, A.

2017-12-01

Public schools and youth voices are largely absent from climate resilience planning and projects in New York City. Additionally, research shows that U.S. science teachers' understanding of climate science is lacking, hence there is not only an urgent need to train and support teachers on both the science and pedagogy of climate change, but to link climate literacy, resilience thinking and service learning in K-12 education. However, research on participation of students and teachers in authentic, civic-oriented experiences points to increased engagement and learning outcomes in science. The Resilient Schools Consortium (RiSC) Project will address all these needs through an afterschool program in six coastal Brooklyn schools that engages teachers and urban youth (grades 6-12), in school and community climate resilience assessment and project design. The RiSC climate curriculum, co-designed by New York City school teachers with Brooklyn College, the National Wildlife Federation, New York Sea Grant and the Science and Resilience Institute at Jamaica Bay, will begin by helping students to understand the difference between climate and weather. The curriculum makes extensive use of existing resources such as NOAA's Digital Coast and the Coastal Resilience Mapping Portal. Through a series of four modules over two school years, the six RiSC teams will; 1. explore and understand the human-induced drivers of climate change and, particularly, the significant climate and extreme weather related risks to their schools and surrounding communities; 2. complete a climate vulnerability assessment within the school and the community that is aligned to OneNYC - the city's resilience planning document; 3. design and execute a school-based resilience project; and 4. propose resilience guidelines for NYC Department of Education schools. At the end of each school year, the six RiSC teams will convene a RiSC summit with city officials and resilience practitioners to share ideas and

Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells.

Science.gov (United States)

Ohrt, Thomas; Mütze, Jörg; Staroske, Wolfgang; Weinmann, Lasse; Höck, Julia; Crell, Karin; Meister, Gunter; Schwille, Petra

2008-11-01

Studies of RNA interference (RNAi) provide evidence that in addition to the well-characterized cytoplasmic mechanisms, nuclear mechanisms also exist. The mechanism by which the nuclear RNA-induced silencing complex (RISC) is formed in mammalian cells, as well as the relationship between the RNA silencing pathways in nuclear and cytoplasmic compartments is still unknown. Here we show by applying fluorescence correlation and cross-correlation spectroscopy (FCS/FCCS) in vivo that two distinct RISC exist: a large approximately 3 MDa complex in the cytoplasm and a 20-fold smaller complex of approximately 158 kDa in the nucleus. We further show that nuclear RISC, consisting only of Ago2 and a short RNA, is loaded in the cytoplasm and imported into the nucleus. The loaded RISC accumulates in the nucleus depending on the presence of a target, based on an miRNA-like interaction with impaired cleavage of the cognate RNA. Together, these results suggest a new RISC shuttling mechanism between nucleus and cytoplasm ensuring concomitant gene regulation by small RNAs in both compartments.

Robotic, MEMS-based Multi Utility Sample Preparation Instrument for ISS Biological Workstation, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — This project will develop a multi-functional, automated sample preparation instrument for biological wet-lab workstations on the ISS. The instrument is based on a...

Python for Unix and Linux system administration

CERN Document Server

Gift, Noah

2007-01-01

Python is an ideal language for solving problems, especially in Linux and Unix networks. With this pragmatic book, administrators can review various tasks that often occur in the management of these systems, and learn how Python can provide a more efficient and less painful way to handle them. Each chapter in Python for Unix and Linux System Administration presents a particular administrative issue, such as concurrency or data backup, and presents Python solutions through hands-on examples. Once you finish this book, you'll be able to develop your own set of command-line utilities with Pytho

INS3D - NUMERICAL SOLUTION OF THE INCOMPRESSIBLE NAVIER-STOKES EQUATIONS IN THREE-DIMENSIONAL GENERALIZED CURVILINEAR COORDINATES (DEC RISC ULTRIX VERSION)

Science.gov (United States)

Biyabani, S. R.

1994-01-01

-field boundaries. Three machine versions of INS3D are available. INS3D for the CRAY is written in CRAY FORTRAN for execution on a CRAY X-MP under COS, INS3D for the IBM is written in FORTRAN 77 for execution on an IBM 3090 under the VM or MVS operating system, and INS3D for DEC RISC-based systems is written in RISC FORTRAN for execution on a DEC workstation running RISC ULTRIX 3.1 or later. The CRAY version has a central memory requirement of 730279 words. The central memory requirement for the IBM is 150Mb. The memory requirement for the DEC RISC ULTRIX version is 3Mb of main memory. INS3D was developed in 1987. The port to the IBM was done in 1990. The port to the DECstation 3100 was done in 1991. CRAY is a registered trademark of Cray Research Inc. IBM is a registered trademark of International Business Machines. DEC, DECstation, and ULTRIX are trademarks of the Digital Equipment Corporation.

Psychometrische kwaliteiten van de Recidive Inschattingsschalen (RISc) : Interbeoordelaarsbetrouwbaarheid, interne consistentie en congruente validiteit

NARCIS (Netherlands)

Knaap, L.M. van der; Leenarts, L.E.W.; Nijssen, L.T.J.

2007-01-01

Het instrument Recidive Inschattings Schalen (RISc) is gebaseerd op een Engelstalig instrument (OASys). Tijdens de ontwikkeling van de RISc is aandacht besteed aan de vertaling van het instrument, aan de kwaliteit van de items en aan de interne consistentie van de schalen van het instrument. Verder

Slicer-independent mechanism drives small-RNA strand separation during human RISC assembly.

Science.gov (United States)

Park, June Hyun; Shin, Chanseok

2015-10-30

Small RNA silencing is mediated by the effector RNA-induced silencing complex (RISC) that consists of an Argonaute protein (AGOs 1-4 in humans). A fundamental step during RISC assembly involves the separation of two strands of a small RNA duplex, whereby only the guide strand is retained to form the mature RISC, a process not well understood. Despite the widely accepted view that 'slicer-dependent unwinding' via passenger-strand cleavage is a prerequisite for the assembly of a highly complementary siRNA into the AGO2-RISC, here we show by careful re-examination that 'slicer-independent unwinding' plays a more significant role in human RISC maturation than previously appreciated, not only for a miRNA duplex, but, unexpectedly, for a highly complementary siRNA as well. We discovered that 'slicer-dependency' for the unwinding was affected primarily by certain parameters such as temperature and Mg(2+). We further validate these observations in non-slicer AGOs (1, 3 and 4) that can be programmed with siRNAs at the physiological temperature of humans, suggesting that slicer-independent mechanism is likely a common feature of human AGOs. Our results now clearly explain why both miRNA and siRNA are found in all four human AGOs, which is in striking contrast to the strict small-RNA sorting system in Drosophila. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Doing accelerator physics using SDDS, UNIX, and EPICS

International Nuclear Information System (INIS)

Borland, M.; Emery, L.; Sereno, N.

1995-01-01

The use of the SDDS (Self-Describing Data Sets) file protocol, together with the UNIX operating system and EPICS (Experimental Physics and Industrial Controls System), has proved powerful during the commissioning of the APS (Advanced Photon Source) accelerator complex. The SDDS file protocol has permitted a tool-oriented approach to developing applications, wherein generic programs axe written that function as part of multiple applications. While EPICS-specific tools were written for data collection, automated experiment execution, closed-loop control, and so forth, data processing and display axe done with the SDDS Toolkit. Experiments and data reduction axe implemented as UNIX shell scripts that coordinate the execution of EPICS specific tools and SDDS tools. Because of the power and generic nature of the individual tools and of the UNIX shell environment, automated experiments can be prepared and executed rapidly in response to unanticipated needs or new ideas. Examples are given of application of this methodology to beam motion characterization, beam-position-monitor offset measurements, and klystron characterization

RISC-Target Interaction: Cleavage and Translational Suppression

Science.gov (United States)

van den Berg, Arjen; Mols, Johann; Han, Jiahuai

2008-01-01

Summary Small RNA molecules have been known and utilized to suppress gene expression for more than a decade. The discovery that these small RNA molecules are endogenously expressed in many organisms and have a critical role in controlling gene expression have led to the arising of a whole new field of research. Termed small interfering RNA (siRNA) or microRNA (miRNA) these ~22 nt RNA molecules have the capability to suppress gene expression through various mechanisms once they are incorporated in the multi-protein RNA-Induced Silencing Complex (RISC) and interact with their target mRNA. This review introduces siRNAs and microRNAs in a historical perspective and focuses on the key molecules in RISC, structural properties and mechanisms underlying the process of small RNA regulated post-transcriptional suppression of gene expression. PMID:18692607

Engineering workstation: Sensor modeling

Science.gov (United States)

Pavel, M; Sweet, B.

1993-01-01

The purpose of the engineering workstation is to provide an environment for rapid prototyping and evaluation of fusion and image processing algorithms. Ideally, the algorithms are designed to optimize the extraction of information that is useful to a pilot for all phases of flight operations. Successful design of effective fusion algorithms depends on the ability to characterize both the information available from the sensors and the information useful to a pilot. The workstation is comprised of subsystems for simulation of sensor-generated images, image processing, image enhancement, and fusion algorithms. As such, the workstation can be used to implement and evaluate both short-term solutions and long-term solutions. The short-term solutions are being developed to enhance a pilot's situational awareness by providing information in addition to his direct vision. The long term solutions are aimed at the development of complete synthetic vision systems. One of the important functions of the engineering workstation is to simulate the images that would be generated by the sensors. The simulation system is designed to use the graphics modeling and rendering capabilities of various workstations manufactured by Silicon Graphics Inc. The workstation simulates various aspects of the sensor-generated images arising from phenomenology of the sensors. In addition, the workstation can be used to simulate a variety of impairments due to mechanical limitations of the sensor placement and due to the motion of the airplane. Although the simulation is currently not performed in real-time, sequences of individual frames can be processed, stored, and recorded in a video format. In that way, it is possible to examine the appearance of different dynamic sensor-generated and fused images.

Computer networks and advanced communications

International Nuclear Information System (INIS)

Koederitz, W.L.; Macon, B.S.

1992-01-01

One of the major methods for getting the most productivity and benefits from computer usage is networking. However, for those who are contemplating a change from stand-alone computers to a network system, the investigation of actual networks in use presents a paradox: network systems can be highly productive and beneficial; at the same time, these networks can create many complex, frustrating problems. The issue becomes a question of whether the benefits of networking are worth the extra effort and cost. In response to this issue, the authors review in this paper the implementation and management of an actual network in the LSU Petroleum Engineering Department. The network, which has been in operation for four years, is large and diverse (50 computers, 2 sites, PC's, UNIX RISC workstations, etc.). The benefits, costs, and method of operation of this network will be described, and an effort will be made to objectively weigh these elements from the point of view of the average computer user

A Fault-tolerant RISC Microprocessor for Spacecraft Applications

Science.gov (United States)

Timoc, Constantin; Benz, Harry

1990-01-01

Viewgraphs on a fault-tolerant RISC microprocessor for spacecraft applications are presented. Topics covered include: reduced instruction set computer; fault tolerant registers; fault tolerant ALU; and double rail CMOS logic.

Computers are stepping stones to improved imaging.

Science.gov (United States)

Freiherr, G

1991-02-01

Never before has the radiology industry embraced the computer with such enthusiasm. Graphics supercomputers as well as UNIX- and RISC-based computing platforms are turning up in every digital imaging modality and especially in systems designed to enhance and transmit images, says author Greg Freiherr on assignment for Computers in Healthcare at the Radiological Society of North America conference in Chicago.

CD-based image archival and management on a hybrid radiology intranet.

Science.gov (United States)

Cox, R D; Henri, C J; Bret, P M

1997-08-01

This article describes the design and implementation of a low-cost image archival and management solution on a radiology network consisting of UNIX, IBM personal computer-compatible (IBM, Purchase, NY) and Macintosh (Apple Computer, Cupertino, CA) workstations. The picture archiving and communications system (PACS) is modular, scaleable and conforms to the Digital Imaging and Communications in Medicine (DICOM) 3.0 standard for image transfer, storage and retrieval. Image data is made available on soft-copy reporting workstations by a work-flow management scheme and on desktop computers through a World Wide Web (WWW) interface. Data archival is based on recordable compact disc (CD) technology and is automated. The project has allowed the radiology department to eliminate the use of film in magnetic resonance (MR) imaging, computed tomography (CT) and ultrasonography.

Development of PSA workstation KIRAP

Energy Technology Data Exchange (ETDEWEB)

Kim, Tae Un; Han, Sang Hoon; Kim, Kil You; Yang, Jun Eon; Jeong, Won Dae; Chang, Seung Cheol; Sung, Tae Yong; Kang, Dae Il; Park, Jin Hee; Lee, Yoon Hwan; Hwang, Mi Jeong

1997-01-01

Advanced Research Group of Korea Atomic Energy Research Institute has been developing the Probabilistic Safety Assessment(PSA) workstation KIRAP from 1992. This report describes the recent development activities of PSA workstation KIRAP. The first is to develop and improve the methodologies for PSA quantification, that are the incorporation of fault tree modularization technique, the improvement of cut set generation method, the development of rule-based recovery, the development of methodology to solve a fault tree which has the logical loops and to handle a fault tree which has several initiators. These methodologies are incorporated in the PSA quantification software KIRAP-CUT. The second is to convert PSA modeling softwares for Windows, which have been used on the DOS environment since 1987. The developed softwares are the fault tree editor KWTREE, the event tree editor CONPAS, and Data manager KWDBMAN for event data and common cause failure (CCF) data. With the development of PSA workstation, it makes PSA modeling and PSA quantification and automation easier and faster. (author). 8 refs.

Development of PSA workstation KIRAP

International Nuclear Information System (INIS)

Kim, Tae Un; Han, Sang Hoon; Kim, Kil You; Yang, Jun Eon; Jeong, Won Dae; Chang, Seung Cheol; Sung, Tae Yong; Kang, Dae Il; Park, Jin Hee; Lee, Yoon Hwan; Hwang, Mi Jeong.

1997-01-01

Advanced Research Group of Korea Atomic Energy Research Institute has been developing the Probabilistic Safety Assessment(PSA) workstation KIRAP from 1992. This report describes the recent development activities of PSA workstation KIRAP. The first is to develop and improve the methodologies for PSA quantification, that are the incorporation of fault tree modularization technique, the improvement of cut set generation method, the development of rule-based recovery, the development of methodology to solve a fault tree which has the logical loops and to handle a fault tree which has several initiators. These methodologies are incorporated in the PSA quantification software KIRAP-CUT. The second is to convert PSA modeling softwares for Windows, which have been used on the DOS environment since 1987. The developed softwares are the fault tree editor KWTREE, the event tree editor CONPAS, and Data manager KWDBMAN for event data and common cause failure (CCF) data. With the development of PSA workstation, it makes PSA modeling and PSA quantification and automation easier and faster. (author). 8 refs

ARC2D - EFFICIENT SOLUTION METHODS FOR THE NAVIER-STOKES EQUATIONS (DEC RISC ULTRIX VERSION)

Science.gov (United States)

Biyabani, S. R.

1994-01-01

computers to emulate Cray system time calls, which should be easy to modify for other machines as well. The standard distribution media for this version is a 9-track 1600 BPI ASCII Card Image format magnetic tape. The Cray version was developed in 1987. The IBM ES/3090 version is an IBM port of the Cray version. It is written in IBM VS FORTRAN and has the capability of executing in both vector and parallel modes on the MVS/XA operating system and in vector mode on the VM/XA operating system. Various options of the IBM VS FORTRAN compiler provide new features for the ES/3090 version, including 64-bit arithmetic and up to 2 GB of virtual addressability. The IBM ES/3090 version is available only as a 9-track, 1600 BPI IBM IEBCOPY format magnetic tape. The IBM ES/3090 version was developed in 1989. The DEC RISC ULTRIX version is a DEC port of the Cray version. It is written in FORTRAN 77 for RISC-based Digital Equipment platforms. The memory requirement is approximately 7Mb of main memory. It is available in UNIX tar format on TK50 tape cartridge. The port to DEC RISC ULTRIX was done in 1990. COS and UNICOS are trademarks and Cray is a registered trademark of Cray Research, Inc. IBM, ES/3090, VS FORTRAN, MVS/XA, and VM/XA are registered trademarks of International Business Machines. DEC and ULTRIX are registered trademarks of Digital Equipment Corporation.

Structural insights into RNA processing by the human RISC-loading complex.

Science.gov (United States)

Wang, Hong-Wei; Noland, Cameron; Siridechadilok, Bunpote; Taylor, David W; Ma, Enbo; Felderer, Karin; Doudna, Jennifer A; Nogales, Eva

2009-11-01

Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC). In humans, Argonaute2 (AGO2) assembles with the guide RNA-generating enzyme Dicer and the RNA-binding protein TRBP to form a RISC-loading complex (RLC), which is necessary for efficient transfer of nascent siRNAs and miRNAs from Dicer to AGO2. Here, using single-particle EM analysis, we show that human Dicer has an L-shaped structure. The RLC Dicer's N-terminal DExH/D domain, located in a short 'base branch', interacts with TRBP, whereas its C-terminal catalytic domains in the main body are proximal to AGO2. A model generated by docking the available atomic structures of Dicer and Argonaute homologs into the RLC reconstruction suggests a mechanism for siRNA transfer from Dicer to AGO2.

Workstations studies and radiation protection

International Nuclear Information System (INIS)

Lahaye, T.; Donadille, L.; Rehel, J.L.; Paquet, F.; Beneli, C.; Cordoliani, Y.S.; Vrigneaud, J.M.; Gauron, C.; Petrequin, A.; Frison, D.; Jeannin, B.; Charles, D.; Carballeda, G.; Crouail, P.; Valot, C.

2006-01-01

This day on the workstations studies for the workers follow-up, was organised by the research and health section. Devoted to the company doctors, for the competent persons in radiation protection, for the engineers of safety, it presented examples of methodologies and applications in the medical, industrial domain and the research, so contributing to a better understanding and an application of regulatory measures. The analysis of the workstation has to allow a reduction of the exposures and the risks and lead to the optimization of the medical follow-up. The agenda of this day included the different subjects as follow: evolution of the regulation in matter of demarcation of the regulated zones where the measures of workers protection are strengthened; presentation of the I.R.S.N. guide of help to the realization of a workstation study; implementation of a workstation study: case of radiology; the workstation studies in the research area; Is it necessary to impose the operational dosimetry in the services of radiodiagnostic? The experience feedback of a competent person in radiation protection (P.C.R.) in a hospital environment; radiation protection: elaboration of a good practices guide in medical field; the activities file in nuclear power plant: an evaluation tool of risks for the prevention. Methodological presentation and examples; insulated workstation study; the experience feedback of a provider; Contribution of the ergonomics to the determiners characterization in the ionizing radiation exposure situations;The workstations studies for the internal contamination in the fuel cycle facilities and the consideration of the results in the medical follow-up; R.E.L.I.R. necessity of workstation studies; the consideration of the human factor. (N.C.)

A software program for exchanging MR data

DEFF Research Database (Denmark)

Ring, P B; Jensen, J A; Henriksen, O

1993-01-01

of digital MR images of the human brain. Because there was no common data format, software package was developed for data exchange. This article describes the basic features of the developed software. The software package was written in the language of C and was successfully tested on an IBM-6150 UNIX...... workstation. The software is currently being tested on the following series of UNIX workstations: SUN SPARC, IBM RS6000, and HP 9000/700....

Feasibility study of BES data off-line processing and D/Ds physics analysis on a PC/Linux platform

International Nuclear Information System (INIS)

Rong Gang; He Kanglin; Heng Yuekun; Zhang Chun; Liu Huaimin; Cheng Baosen; Yan Wuguang; Mai Jimao; Zhao Haiwen

2000-01-01

The authors report a feasibility study of BES data off-line processing (BES data off-line reconstruction and Monte Carlo simulation) and D/Ds physics analysis on a PC/Linux platform. The authors compared the results obtained from the PC/Linux with that from HP/UNIX workstation. It shows that PC/Linux platform can do BES data off-line analysis as good as HP/UNIX workstation, and is much powerful and economical

Introduction of the UNIX International Performance Management Work Group

Science.gov (United States)

Newman, Henry

1993-01-01

In this paper we presented the planned direction of the UNIX International Performance Management Work Group. This group consists of concerned system developers and users who have organized to synthesize recommendations for standard UNIX performance management subsystem interfaces and architectures. The purpose of these recommendations is to provide a core set of performance management functions and these functions can be used to build tools by hardware system developers, vertical application software developers, and performance application software developers.

Psychometric Evaluation of the Connor-Davidson Resilience Scale (CD-RISC) Using Iranian Students

Science.gov (United States)

Khoshouei, Mahdieh Sadat

2009-01-01

The purpose of this study was to evaluate the psychometric properties of the Persian version of the Connor-Davidson Resilience Scale (CD-RISC). The CD-RISC was completed by a sample of 323 Isfahan university students (168 females, 155 males) aged 19-34 years. A maximum likelihood method with an oblique solution resulted in four factors…

AVR RISC microcontroller handbook

CERN Document Server

Kuhnel, Claus

1998-01-01

The AVR RISC Microcontroller Handbook is a comprehensive guide to designing with Atmel's new controller family, which is designed to offer high speed and low power consumption at a lower cost. The main text is divided into three sections: hardware, which covers all internal peripherals; software, which covers programming and the instruction set; and tools, which explains using Atmel's Assembler and Simulator (available on the Web) as well as IAR's C compiler.Practical guide for advanced hobbyists or design professionalsDevelopment tools and code available on the Web

Statistical Use of Argonaute Expression and RISC Assembly in microRNA Target Identification

Science.gov (United States)

Stanhope, Stephen A.; Sengupta, Srikumar; den Boon, Johan; Ahlquist, Paul; Newton, Michael A.

2009-01-01

MicroRNAs (miRNAs) posttranscriptionally regulate targeted messenger RNAs (mRNAs) by inducing cleavage or otherwise repressing their translation. We address the problem of detecting m/miRNA targeting relationships in homo sapiens from microarray data by developing statistical models that are motivated by the biological mechanisms used by miRNAs. The focus of our modeling is the construction, activity, and mediation of RNA-induced silencing complexes (RISCs) competent for targeted mRNA cleavage. We demonstrate that regression models accommodating RISC abundance and controlling for other mediating factors fit the expression profiles of known target pairs substantially better than models based on m/miRNA expressions alone, and lead to verifications of computational target pair predictions that are more sensitive than those based on marginal expression levels. Because our models are fully independent of exogenous results from sequence-based computational methods, they are appropriate for use as either a primary or secondary source of information regarding m/miRNA target pair relationships, especially in conjunction with high-throughput expression studies. PMID:19779550

Development and Transition of the Radiation, Interplanetary Shocks, and Coronal Sources (RISCS) Toolset

Science.gov (United States)

Spann, James F.; Zank, G.

2014-01-01

We outline a plan to develop and transition a physics based predictive toolset called The Radiation, Interplanetary Shocks, and Coronal Sources (RISCS) to describe the interplanetary energetic particle and radiation environment throughout the inner heliosphere, including at the Earth. To forecast and "nowcast" the radiation environment requires the fusing of three components: 1) the ability to provide probabilities for incipient solar activity; 2) the use of these probabilities and daily coronal and solar wind observations to model the 3D spatial and temporal heliosphere, including magnetic field structure and transients, within 10 Astronomical Units; and 3) the ability to model the acceleration and transport of energetic particles based on current and anticipated coronal and heliospheric conditions. We describe how to address 1) - 3) based on our existing, well developed, and validated codes and models. The goal of RISCS toolset is to provide an operational forecast and "nowcast" capability that will a) predict solar energetic particle (SEP) intensities; b) spectra for protons and heavy ions; c) predict maximum energies and their duration; d) SEP composition; e) cosmic ray intensities, and f) plasma parameters, including shock arrival times, strength and obliquity at any given heliospheric location and time. The toolset would have a 72 hour predicative capability, with associated probabilistic bounds, that would be updated hourly thereafter to improve the predicted event(s) and reduce the associated probability bounds. The RISCS toolset would be highly adaptable and portable, capable of running on a variety of platforms to accommodate various operational needs and requirements. The described transition plan is based on a well established approach developed in the Earth Science discipline that ensures that the customer has a tool that meets their needs

Communication System Simulation Workstation

Science.gov (United States)

1990-01-30

SIMULATION WORKSTATION Grant # AFOSR-89-0117 Submitted to: DEPARTMENT OF AIR FORCE AIR FORCE OFFICE OF SCIENTIFIC RESEARCH BOLLING AIR FORCE BASE , DC...CORRESPONOENCiA. PAGUETES. CONIIUCE. r ACTUHA. Y CONOCIMIENTO DE EMBAROUES. THIS PURCHASE ORDER [,rccion Cablegralica .1,1 Addrv~s NO MUST APPEAR ON ALL...sub-band decomposition was developed, PKX, based on the modulation of a single prototype filter. This technicde was introduced first by Nassbauner and

The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly.

Science.gov (United States)

Martinez, Natalia J; Chang, Hao-Ming; Borrajo, Jacob de Riba; Gregory, Richard I

2013-11-01

Argonaute2 (Ago2) protein and associated microRNAs (miRNAs) or small interfering RNAs (siRNAs) form the RNA-induced silencing complex (RISC) for target messenger RNA cleavage and post-transcriptional gene silencing. Although Ago2 is essential for RISC activity, the mechanism of RISC assembly is not well understood, and factors controlling Ago2 protein expression are largely unknown. A role for the Hsc70/Hsp90 chaperone complex in loading small RNA duplexes into the RISC has been demonstrated in cell extracts, and unloaded Ago2 is unstable and degraded by the lysosome in mammalian cells. Here we identify the co-chaperones Fkbp4 and Fkbp5 as Ago2-associated proteins in mouse embryonic stem cells. Pharmacological inhibition of this interaction using FK506 or siRNA-mediated Fkbp4/5 depletion leads to decreased Ago2 protein levels. We find FK506 treatment inhibits, whereas Fkbp4/5 overexpression promotes, miRNA-mediated stabilization of Ago2 expression. Simultaneous treatment with a lysosome inhibitor revealed the accumulation of unloaded Ago2 complexes in FK506-treated cells. We find that, consistent with unloaded miRNAs being unstable, FK506 treatment also affects miRNA abundance, particularly nascent miRNAs. Our results support a role for Fkbp4/5 in RISC assembly.

RISC mezzanines for controlling data acquisition in the NA48 experiment at CERN

International Nuclear Information System (INIS)

Guzik, Z.; Chlopik, A.; Bal, Fr.; Formenti, F.; Lacourt, A.

2000-01-01

A part of the LKr calorimeter data acquisition system of the NA48 experiment (a precision measurements of ε/ε' in CP violating; K 0 →2π decays) is described. The experiment runs on the SPS north area in CERN. This paper presents some aspects of controlling the NA48 readout process based on commercial RIO 8260 RISC processors, which were used as a core for maintaining control algorithms. Several RISC processors were equipped with custom-made VME mezzanine boards providing interfacing, pre-processing and data formatting. These mezzanines are subjects of this paper. They are: RIO-TIC/DAT - time stamp distributor and buffered DT-bus interface, FOL-RIO - optical data formatter and event merger and 'TAXI receiver' - handling trigger data of the NA48 Level 2 trigger supervisor. Also the interface between DT-bus and S-link/PCI is described

Development of a graphical user interface and graphics display for the WIND system

International Nuclear Information System (INIS)

O'Steen, B.L.; Fast, J.D.; Suire, B.S.

1992-01-01

An advanced graphical user interface (GUI) and improved graphics for transport calculations have been developed for the Weather Information and Display System (WINDS). Two WINDS transport codes, Area Evac and 2DPUF, have been ported from their original VAX/VMS environment to a UNIX operating system and reconfigured to take advantage of the new graphics capability. A developmental prototype of this software is now available on a UNIX based IBM 340 workstation in the Dose Assessment Center (DAC). Automatic transfer of meteorological data from the WINDS VAX computers to the IBM workstation in the DAC has been implemented. This includes both regional National Weather Service (NWS) data and SRS tower data. The above developments fulfill a FY 1993 DOE milestone

Expert system based radionuclide identification

International Nuclear Information System (INIS)

Aarnio, P.A.; Ala-Heikkil, J.J.; Hakulinen, T.T.; Nikkinen, M.T.

1998-01-01

An expert system coupled with the gamma spectrum analysis system SAMPO has been developed for automating the qualitative identification of radionuclides as well as for determining the quantitative parameters of the spectrum components. The program is written in C-language and runs in various environments ranging from PCs to UNIX workstations. The expert system utilizes a complete gamma library with over 2600 nuclides and 80,000 lines, and a rule base of about fifty criteria including energies, relative peak intensities, genesis modes, half lives, parent-daughter relationships, etc. The rule base is furthermore extensible by the user. This is not an original contribution but a somewhat updated version of papers and reports previously published elsewhere. (author)

Burden to importance ratio as a quantitative measure to validate the RISC-3 SSC in OPTION-2

International Nuclear Information System (INIS)

Ha, J. S.; Sung, P. H.

2004-01-01

A Risk-Informed Safety Significance Categorization (RISSC) is to categorize structures, systems, or components (SSCs) of a Nuclear Power Plant (NPP) into two or more groups, according to their safety significance using both probabilistic and deterministic insights. Recently, OPTION-2 (which is an emerging risk-informed paradigm) recommends that SSCs should be categorized into four groups according to whether they are safety-related or not as well as their safety significance. With the change of 10 CFR 50, safety-related components which categorized into low safety significant SSC (RISC-3 SSC) can be exempted from the existing conservative requirements. Consequently, as OPTION-2 paradigm is applied, a validation process focused on the RISC-3 SSC is needed to assure the categorization results, because most of existing RISSC methods focused on the categorization of the whole SSCs of NPPs based on importance measures obtained from probabilistic and deterministic insights. In this work, Burden to Importance Ratio (BIR) is utilized as a measure for the validation of RISC-3 SSC in OPTION-2. To demonstrate the usefulness of the proposed approach, the approach is applied to 22 components selected from 512 In-Service Test (IST) components of Ulchin unit 3. The results of the application show that the proposed approach is useful for the validation of RISC-3 SSC in OPTION-2

TAF11 assembles RISC loading complex to enhance RNAi efficiency

Science.gov (United States)

Liang, Chunyang; Wang, Yibing; Murota, Yukiko; Liu, Xiang; Smith, Dean; Siomi, Mikiko C.; Liu, Qinghua

2015-01-01

SUMMARY Assembly of the RNA-induced silencing complex (RISC) requires formation of the RISC loading complex (RLC), which contains Dicer-2(Dcr-2)-R2D2 complex and recruits duplex siRNA to Ago2 in Drosophila melanogaster. However, the precise composition and action mechanism of Drosophila RLC remain unclear. Here, we identified the missing factor of RLC as TATA-binding protein associated factor 11 (TAF11) by genetic screen. Although an annotated nuclear transcription factor, we found that TAF11 also associated with Dcr-2/R2D2 and localized to cytoplasmic D2 bodies. Consistent with defective RLC assembly in taf11−/− ovary extract, we reconstituted the RLC in vitro using recombinant Dcr-2-R2D2 complex, TAF11, and duplex siRNA. Furthermore, we showed that TAF11 tetramer facilitates Dcr-2-R2D2 tetramerization to enhance siRNA binding and RISC loading activities. Together, our genetic and biochemical studies define the molecular nature of Drosophila RLC and elucidate a novel cytoplasmic function of TAF11 in organizing RLC assembly to enhance RNAi efficiency. PMID:26257286

Migration of the UNIX Application for eFAST CANDU Nuclear Power Plant Analyzer

International Nuclear Information System (INIS)

Suh, Jae Seung; Sohn, Dae Seong; Kim, Sang Jae; Jeun, Gyoo Dong

2006-01-01

Since the mid 1980s, corporate data centers have been moving away from mainframes running dedicated operating systems to mini-computers, often using one or other of the myriad flavors of UNIX. At the same time, the users' experience of these systems has, in many cases, stayed the same, involving text-based interaction with dumb terminals or a terminal-emulation session on a Personal Computer. More recently, IT managers have questioned this approach, and have been looking at changes in the UNIX marketplace and the increasing expense of being tied in to single-vendor software and hardware solutions. The growth of Linux as a lightweight version of UNIX has fueled this interest, raising the number of organizations that are considering a migration to alternative platforms. The various implementations of the UNIX operating system have served industry well, as witnessed by the very large base both of installed systems and large-scale applications installed on those systems. However, there are increasing signs of dissatisfaction with expensive, often proprietary solutions and a growing sense that perhaps the concept of 'big iron' has had its day in the same way as it has for most of the mainframes of the type portrayed in 1970s science fiction films. One of the most extraordinary and unexpected successes of the Intel PC architecture is the extent to which this basic framework has been extended to encompass very large server and data center environments. Large-scale hosting companies are now offering enterprise level services to multiple client companies at availability levels of over 99.99 percent on what are simply racks of relatively cheap PCs. Technologies such as clustering, Network Load Balancing, and Component Load Balancing enable the personal computer to take on and match the levels of throughput, availability, and reliability of all but the most expensive 'big iron' solutions and the supercomputers

Event parallelism: Distributed memory parallel computing for high energy physics experiments

International Nuclear Information System (INIS)

Nash, T.

1989-05-01

This paper describes the present and expected future development of distributed memory parallel computers for high energy physics experiments. It covers the use of event parallel microprocessor farms, particularly at Fermilab, including both ACP multiprocessors and farms of MicroVAXES. These systems have proven very cost effective in the past. A case is made for moving to the more open environment of UNIX and RISC processors. The 2nd Generation ACP Multiprocessor System, which is based on powerful RISC systems, is described. Given the promise of still more extraordinary increases in processor performance, a new emphasis on point to point, rather than bussed, communication will be required. Developments in this direction are described. 6 figs

Event parallelism: Distributed memory parallel computing for high energy physics experiments

International Nuclear Information System (INIS)

Nash, T.

1989-01-01

This paper describes the present and expected future development of distributed memory parallel computers for high energy physics experiments. It covers the use of event parallel microprocessor farms, particularly at Fermilab, including both ACP multiprocessors and farms of MicroVAXES. These systems have proven very cost effective in the past. A case is made for moving to the more open environment of UNIX and RISC processors. The 2nd Generation ACP Multiprocessor System, which is based on powerful RISC systems, is described. Given the promise of still more extraordinary increases in processor performance, a new emphasis on point to point, rather than bussed, communication will be required. Developments in this direction are described. (orig.)

Event parallelism: Distributed memory parallel computing for high energy physics experiments

Science.gov (United States)

Nash, Thomas

1989-12-01

This paper describes the present and expected future development of distributed memory parallel computers for high energy physics experiments. It covers the use of event parallel microprocessor farms, particularly at Fermilab, including both ACP multiprocessors and farms of MicroVAXES. These systems have proven very cost effective in the past. A case is made for moving to the more open environment of UNIX and RISC processors. The 2nd Generation ACP Multiprocessor System, which is based on powerful RISC system, is described. Given the promise of still more extraordinary increases in processor performance, a new emphasis on point to point, rather than bussed, communication will be required. Developments in this direction are described.

Spanish validation of the 10-item Connor-Davidson Resilience Scale (CD-RISC 10) with non-professional caregivers.

Science.gov (United States)

Blanco, Vanessa; Guisande, María Adelina; Sánchez, María Teresa; Otero, Patricia; Vázquez, Fernando L

2017-11-08

Despite the importance of resilience in populations under stress, and the fact that the 10-item version Connor-Davidson Resilience Scale (CD-RISC 10) is the shortest instrument for reliable and valid evaluation of resilience, there are no data on their psychometric properties in non-professional caregivers. The aim of this study was to analyze the psychometric properties and factorial structure of the spanish version of the CD-RISC 10 in non-professional caregivers. Independently trained assessors evaluated resilience, self-esteem, social support, emotional distress and depression in a sample of 294 caregivers (89.8% women, mean age 55.3 years). The internal consistency of CD-RISC 10 was α = .86. A single factor was found that accounted for 44.7% of the total variance. Confirmatory factor analysis corroborated this unifactorial model. The CD-RISC 10 was significantly correlated with the self-esteem (r = .416, p caregivers with depression (sensitivity = 70.0%, specificity = 68.2%). The CD-RISC 10 is a reliable and valid instrument to evaluate resilience in the caregiver population.

RISC mezzanines for controlling data acquisition in the NA48 experiment at CERN

CERN Document Server

Guzik, Z; Bal, F; Formenti, F; Lacourt, A

2000-01-01

A part of the LKr calorimeter data acquisition system of the NA48 experiment (a precision measurements of epsilon / epsilon ' in CP- violating K/sup 0/ to 2 pi decays) is described. The experiment runs on the SPS north area in CERN. This paper presents some aspects of controlling the NA48 readout process based on commercial RIO 8260 RISC processors, which were used as a core for maintaining control algorithms. Several RISC processors were equipped with custom-made VME mezzanine boards providing interfacing, pre-processing and data formatting. These mezzanines are the subjects of this paper. They are: RIO-TIC/DAT (a time-stamp distributor and buffered DT-bus interface), FOL-RIO (an optical data formatter and event merger) and "TAXI receiver" (for handling trigger data of the NA48 Level-2 trigger supervisor). Also, the interface between the DT-bus and S- link/PCI is described. (8 refs).

Pc-Based Floating Point Imaging Workstation

Science.gov (United States)

Guzak, Chris J.; Pier, Richard M.; Chinn, Patty; Kim, Yongmin

1989-07-01

The medical, military, scientific and industrial communities have come to rely on imaging and computer graphics for solutions to many types of problems. Systems based on imaging technology are used to acquire and process images, and analyze and extract data from images that would otherwise be of little use. Images can be transformed and enhanced to reveal detail and meaning that would go undetected without imaging techniques. The success of imaging has increased the demand for faster and less expensive imaging systems and as these systems become available, more and more applications are discovered and more demands are made. From the designer's perspective the challenge to meet these demands forces him to attack the problem of imaging from a different perspective. The computing demands of imaging algorithms must be balanced against the desire for affordability and flexibility. Systems must be flexible and easy to use, ready for current applications but at the same time anticipating new, unthought of uses. Here at the University of Washington Image Processing Systems Lab (IPSL) we are focusing our attention on imaging and graphics systems that implement imaging algorithms for use in an interactive environment. We have developed a PC-based imaging workstation with the goal to provide powerful and flexible, floating point processing capabilities, along with graphics functions in an affordable package suitable for diverse environments and many applications.

Benchmarking of SIMULATE-3 on engineering workstations

International Nuclear Information System (INIS)

Karlson, C.F.; Reed, M.L.; Webb, J.R.; Elzea, J.D.

1990-01-01

The nuclear fuel management department of Arizona Public Service Company (APS) has evaluated various computer platforms for a departmental engineering and business work-station local area network (LAN). Historically, centralized mainframe computer systems have been utilized for engineering calculations. Increasing usage and the resulting longer response times on the company mainframe system and the relative cost differential between a mainframe upgrade and workstation technology justified the examination of current workstations. A primary concern was the time necessary to turn around routine reactor physics reload and analysis calculations. Computers ranging from a Definicon 68020 processing board in an AT compatible personal computer up to an IBM 3090 mainframe were benchmarked. The SIMULATE-3 advanced nodal code was selected for benchmarking based on its extensive use in nuclear fuel management. SIMULATE-3 is used at APS for reload scoping, design verification, core follow, and providing predictions of reactor behavior under nominal conditions and planned reactor maneuvering, such as axial shape control during start-up and shutdown

ANL statement of site strategy for computing workstations

Energy Technology Data Exchange (ETDEWEB)

Fenske, K.R. (ed.); Boxberger, L.M.; Amiot, L.W.; Bretscher, M.E.; Engert, D.E.; Moszur, F.M.; Mueller, C.J.; O' Brien, D.E.; Schlesselman, C.G.; Troyer, L.J.

1991-11-01

This Statement of Site Strategy describes the procedure at Argonne National Laboratory for defining, acquiring, using, and evaluating scientific and office workstations and related equipment and software in accord with DOE Order 1360.1A (5-30-85), and Laboratory policy. It is Laboratory policy to promote the installation and use of computing workstations to improve productivity and communications for both programmatic and support personnel, to ensure that computing workstations acquisitions meet the expressed need in a cost-effective manner, and to ensure that acquisitions of computing workstations are in accord with Laboratory and DOE policies. The overall computing site strategy at ANL is to develop a hierarchy of integrated computing system resources to address the current and future computing needs of the laboratory. The major system components of this hierarchical strategy are: Supercomputers, Parallel computers, Centralized general purpose computers, Distributed multipurpose minicomputers, and Computing workstations and office automation support systems. Computing workstations include personal computers, scientific and engineering workstations, computer terminals, microcomputers, word processing and office automation electronic workstations, and associated software and peripheral devices costing less than $25,000 per item.

VAX Professional Workstation goes graphic

International Nuclear Information System (INIS)

Downward, J.G.

1984-01-01

The VAX Professional Workstation (VPW) is a collection of programs and procedures designed to provide an integrated work-station environment for the staff at KMS Fusion's research laboratories. During the past year numerous capabilities have been added to VPW, including support for VT125/VT240/4014 graphic workstations, editing windows, and additional desk utilities. Graphics workstation support allows users to create, edit, and modify graph data files, enter the data via a graphic tablet, create simple plots with DATATRIEVE or DECgraph on ReGIS terminals, or elaborate plots with TEKGRAPH on ReGIS or Tektronix terminals. Users may assign display error bars to the data and interactively plot it in a variety of ways. Users also can create and display viewgraphs. Hard copy output for a large network of office terminals is obtained by multiplexing each terminal's video output into a recently developed video multiplexer front ending a single channel video hard copy unit

TAF11 Assembles the RISC Loading Complex to Enhance RNAi Efficiency.

Science.gov (United States)

Liang, Chunyang; Wang, Yibing; Murota, Yukiko; Liu, Xiang; Smith, Dean; Siomi, Mikiko C; Liu, Qinghua

2015-09-03

Assembly of the RNA-induced silencing complex (RISC) requires formation of the RISC loading complex (RLC), which contains the Dicer-2 (Dcr-2)-R2D2 complex and recruits duplex siRNA to Ago2 in Drosophila melanogaster. However, the precise composition and action mechanism of Drosophila RLC remain unclear. Here we identified the missing factor of RLC as TATA-binding protein-associated factor 11 (TAF11) by genetic screen. Although it is an annotated nuclear transcription factor, we found that TAF11 also associated with Dcr-2/R2D2 and localized to cytoplasmic D2 bodies. Consistent with defective RLC assembly in taf11(-/-) ovary extract, we reconstituted the RLC in vitro using the recombinant Dcr-2-R2D2 complex, TAF11, and duplex siRNA. Furthermore, we showed that TAF11 tetramer facilitates Dcr-2-R2D2 tetramerization to enhance siRNA binding and RISC loading activities. Together, our genetic and biochemical studies define the molecular nature of the Drosophila RLC and elucidate a cytoplasmic function of TAF11 in organizing RLC assembly to enhance RNAi efficiency. Copyright © 2015 Elsevier Inc. All rights reserved.

Computer-aided diagnosis workstation and network system for chest diagnosis based on multislice CT images

Science.gov (United States)

Satoh, Hitoshi; Niki, Noboru; Eguchi, Kenji; Moriyama, Noriyuki; Ohmatsu, Hironobu; Masuda, Hideo; Machida, Suguru

2008-03-01

Mass screening based on multi-helical CT images requires a considerable number of images to be read. It is this time-consuming step that makes the use of helical CT for mass screening impractical at present. To overcome this problem, we have provided diagnostic assistance methods to medical screening specialists by developing a lung cancer screening algorithm that automatically detects suspected lung cancers in helical CT images, a coronary artery calcification screening algorithm that automatically detects suspected coronary artery calcification and a vertebra body analysis algorithm for quantitative evaluation of osteoporosis likelihood by using helical CT scanner for the lung cancer mass screening. The function to observe suspicious shadow in detail are provided in computer-aided diagnosis workstation with these screening algorithms. We also have developed the telemedicine network by using Web medical image conference system with the security improvement of images transmission, Biometric fingerprint authentication system and Biometric face authentication system. Biometric face authentication used on site of telemedicine makes "Encryption of file" and Success in login" effective. As a result, patients' private information is protected. Based on these diagnostic assistance methods, we have developed a new computer-aided workstation and a new telemedicine network that can display suspected lesions three-dimensionally in a short time. The results of this study indicate that our radiological information system without film by using computer-aided diagnosis workstation and our telemedicine network system can increase diagnostic speed, diagnostic accuracy and security improvement of medical information.

Computer-aided diagnosis workstation and telemedicine network system for chest diagnosis based on multislice CT images

Science.gov (United States)

Satoh, Hitoshi; Niki, Noboru; Eguchi, Kenji; Ohmatsu, Hironobu; Kakinuma, Ryutaru; Moriyama, Noriyuki

2009-02-01

Mass screening based on multi-helical CT images requires a considerable number of images to be read. It is this time-consuming step that makes the use of helical CT for mass screening impractical at present. Moreover, the doctor who diagnoses a medical image is insufficient in Japan. To overcome these problems, we have provided diagnostic assistance methods to medical screening specialists by developing a lung cancer screening algorithm that automatically detects suspected lung cancers in helical CT images, a coronary artery calcification screening algorithm that automatically detects suspected coronary artery calcification and a vertebra body analysis algorithm for quantitative evaluation of osteoporosis likelihood by using helical CT scanner for the lung cancer mass screening. The functions to observe suspicious shadow in detail are provided in computer-aided diagnosis workstation with these screening algorithms. We also have developed the telemedicine network by using Web medical image conference system with the security improvement of images transmission, Biometric fingerprint authentication system and Biometric face authentication system. Biometric face authentication used on site of telemedicine makes "Encryption of file" and "Success in login" effective. As a result, patients' private information is protected. We can share the screen of Web medical image conference system from two or more web conference terminals at the same time. An opinion can be exchanged mutually by using a camera and a microphone that are connected with workstation. Based on these diagnostic assistance methods, we have developed a new computer-aided workstation and a new telemedicine network that can display suspected lesions three-dimensionally in a short time. The results of this study indicate that our radiological information system without film by using computer-aided diagnosis workstation and our telemedicine network system can increase diagnostic speed, diagnostic accuracy and

The scheme and implementing of workstation configuration for medical imaging information system

International Nuclear Information System (INIS)

Tao Yonghao; Miao Jingtao

2002-01-01

Objective: To discuss the scheme and implementing for workstation configuration of medical imaging information system which would be adapted to the practice situation of China. Methods: The workstations were logically divided into PACS workstations and RIS workstations, the former applied to three kinds of diagnostic practice: the small matrix images, large matrix images, and high resolution gray scale display application, and the latter consisted of many different models which depended upon the usage and function process. Results: A dual screen configuration for image diagnostic workstation integrated the image viewing and reporting procedure physically, while the small matrix images as CT or MR were operated on 17 in (1 in = 2.54 cm) color monitors, the conventional X-ray diagnostic procedure was implemented based on 21 in color monitors or portrait format gray scale 2 K by 2.5 K monitors. All other RIS workstations not involved in image process were set up with a common PC configuration. Conclusion: The essential principle for designing a workstation scheme of medical imaging information system should satisfy the basic requirements of medical image diagnosis and fit into the available investment situation

The UNIX/XENIX Advantage: Applications in Libraries.

Science.gov (United States)

Gordon, Kelly L.

1988-01-01

Discusses the application of the UNIX/XENIX operating system to support administrative office automation functions--word processing, spreadsheets, database management systems, electronic mail, and communications--at the Central Michigan University Libraries. Advantages and disadvantages of the XENIX operating system and system configuration are…

Optimization of Particle-in-Cell Codes on RISC Processors

Science.gov (United States)

Decyk, Viktor K.; Karmesin, Steve Roy; Boer, Aeint de; Liewer, Paulette C.

1996-01-01

General strategies are developed to optimize particle-cell-codes written in Fortran for RISC processors which are commonly used on massively parallel computers. These strategies include data reorganization to improve cache utilization and code reorganization to improve efficiency of arithmetic pipelines.

Development of the Respiratory Index of Severity in Children (RISC score among young children with respiratory infections in South Africa.

Directory of Open Access Journals (Sweden)

Carrie Reed

Full Text Available OBJECTIVE: Pneumonia is a leading cause of death in children worldwide. A simple clinical score predicting the probability of death in a young child with lower respiratory tract infection (LRTI could aid clinicians in case management and provide a standardized severity measure during epidemiologic studies. METHODS: We analyzed 4,148 LRTI hospitalizations in children <24 months enrolled in a pneumococcal conjugate vaccine trial in South Africa from 1998-2001, to develop the Respiratory Index of Severity in Children (RISC. Using clinical data at admission, a multivariable logistic regression model for mortality was developed and statistically evaluated using bootstrap resampling techniques. Points were assigned to risk factors based on their coefficients in the multivariable model. A child's RISC score is the sum of points for each risk factor present. Separate models were developed for HIV-infected and non-infected children. RESULTS: Significant risk factors for HIV-infected and non-infected children included low oxygen saturation, chest indrawing, wheezing, and refusal to feed. The models also included age and HIV clinical classification (for HIV-infected children or weight-for-age (for non-infected children. RISC scores ranged up to 7 points for HIV-infected or 6 points for non-infected children and correlated with probability of death (0-47%, HIV-infected; 0-14%, non-infected. Final models showed good discrimination (area under the ROC curve and calibration (goodness-of-fit. CONCLUSION: The RISC score incorporates a simple set of risk factors that accurately discriminate between young children based on their risk of death from LRTI, and may provide an objective means to quantify severity based on the risk of mortality.

UNIX secure server : a free, secure, and functional server example

OpenAIRE

Sastre, Hugo

2016-01-01

The purpose of this thesis work was to introduce UNIX server as a personal server but also as a start point for investigation and developing at a professional level. The objective of this thesis was to build a secure server providing not only a FTP server but also an HTTP server and a cloud system for remote backups. OpenBSD was used as the operating system. OpenBSD is a UNIX-like operating system made by hackers for hackers. The difference with other systems that might partially provid...

Event analysis using a massively parallel processor

International Nuclear Information System (INIS)

Bale, A.; Gerelle, E.; Messersmith, J.; Warren, R.; Hoek, J.

1990-01-01

This paper describes a system for performing histogramming of n-tuple data at interactive rates using a commercial SIMD processor array connected to a work-station running the well-known Physics Analysis Workstation software (PAW). Results indicate that an order of magnitude performance improvement over current RISC technology is easily achievable

The microcomputer workstation - An alternate hardware architecture for remotely sensed image analysis

Science.gov (United States)

Erickson, W. K.; Hofman, L. B.; Donovan, W. E.

1984-01-01

Difficulties regarding the digital image analysis of remotely sensed imagery can arise in connection with the extensive calculations required. In the past, an expensive large to medium mainframe computer system was needed for performing these calculations. For image-processing applications smaller minicomputer-based systems are now used by many organizations. The costs for such systems are still in the range from $100K to $300K. Recently, as a result of new developments, the use of low-cost microcomputers for image processing and display systems appeared to have become feasible. These developments are related to the advent of the 16-bit microprocessor and the concept of the microcomputer workstation. Earlier 8-bit microcomputer-based image processing systems are briefly examined, and a computer workstation architecture is discussed. Attention is given to a microcomputer workstation developed by Stanford University, and the design and implementation of a workstation network.

Theoretical studies in nuclear physics. Three year progress report and final report

International Nuclear Information System (INIS)

Landau, R.H.; Madsen, V.A.

1996-01-01

In 1995 the DOE grant in Nuclear theory with Professors Rubin H. Landau and Victor A. Madsen as co-principal investigators ended. Their research was carried out in collaboration with graduate students in Corvallis, and with scientists at LLNL-Livermore, Los Alamos, TRIUMF, KFA-Julich, Hamburg University, Melbourne University, The Thinking Machine Corporation and IBM Research. Activities in nuclear and particle physics at Oregon State University (OSU) were diverse and active. Madsen's work concentrated on the relation of reactions to the nuclear structure, and Landau's work concentrated on intermediate energy physics, few-body problems, and computational physics. The Landau group had a weekly meeting of students and visitors. There was a weekly nuclear seminar with experimental and theoretical colleagues, and a weekly departmental colloquium. The DOE support had permitted the group to run Unix workstations networked to other computers in the Physics Department and the University. Since 1990 OSU has been using IBM RISC System 6000/model 530 with console and four X-stations. The equipment was purchased and is maintained with yearly DOE funding of the group

Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination.

Science.gov (United States)

Lewkowicz, Przemysław; Cwiklińska, Hanna; Mycko, Marcin P; Cichalewska, Maria; Domowicz, Małgorzata; Lewkowicz, Natalia; Jurewicz, Anna; Selmaj, Krzysztof W

2015-05-13

MicroRNAs (miRNAs) associate with Argonaute (Ago), GW182, and FXR1 proteins to form RNA-induced silencing complexes (RISCs). RISCs represent a critical checkpoint in the regulation and bioavailability of miRNAs. Recent studies have revealed dysregulation of miRNAs in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE); however, the function of RISCs in EAE and MS is largely unknown. Here, we examined the expression of Ago, GW182, and FXR1 in CNS tissue, oligodendrocytes (OLs), brain-infiltrating T lymphocytes, and CD3(+)splenocytes (SCs) of EAE mic, and found that global RISC protein levels were significantly dysregulated. Specifically, Ago2 and FXR1 levels were decreased in OLs and brain-infiltrating T cells in EAE mice. Accordingly, assembly of Ago2/GW182/FXR1 complexes in EAE brain tissues was disrupted, as confirmed by immunoprecipitation experiments. In parallel with alterations in RISC complex content in OLs, we found downregulation of miRNAs essential for differentiation and survival of OLs and myelin synthesis. In brain-infiltrating T lymphocytes, aberrant RISC formation contributed to miRNA-dependent proinflammatory helper T-cell polarization. In CD3(+) SCs, we found increased expression of both Ago2 and FXR1 in EAE compared with nonimmunized mice. Therefore, our results demonstrate a gradient in expression of miRNA between primary activated T cells in the periphery and polarized CNS-infiltrating T cells. These results suggest that, in polarized autoreactive effector T cells, miRNA synthesis is inhibited in response to dysregulated RISC assembly, allowing these cells to maintain a highly specific proinflammatory program. Therefore, our findings may provide a mechanism that leads to miRNA dysregulation in EAE/MS. Copyright © 2015 the authors 0270-6474/15/357521-17$15.00/0.

Design of RISC Processor Using VHDL and Cadence

Science.gov (United States)

Moslehpour, Saeid; Puliroju, Chandrasekhar; Abu-Aisheh, Akram

The project deals about development of a basic RISC processor. The processor is designed with basic architecture consisting of internal modules like clock generator, memory, program counter, instruction register, accumulator, arithmetic and logic unit and decoder. This processor is mainly used for simple general purpose like arithmetic operations and which can be further developed for general purpose processor by increasing the size of the instruction register. The processor is designed in VHDL by using Xilinx 8.1i version. The present project also serves as an application of the knowledge gained from past studies of the PSPICE program. The study will show how PSPICE can be used to simplify massive complex circuits designed in VHDL Synthesis. The purpose of the project is to explore the designed RISC model piece by piece, examine and understand the Input/ Output pins, and to show how the VHDL synthesis code can be converted to a simplified PSPICE model. The project will also serve as a collection of various research materials about the pieces of the circuit.

UNIX at high energy physics Laboratories

Energy Technology Data Exchange (ETDEWEB)

Silverman, Alan

1994-03-15

With more and more high energy physics Laboratories ''downsizing'' from large central proprietary mainframe computers towards distributed networks, usually involving UNIX operating systems, the need was expressed at the 1991 Computers in HEP (CHEP) Conference to create a group to consider the implications of this trend and perhaps work towards some common solutions to ease the transition for HEP users worldwide.

Automated training site selection for large-area remote-sensing image analysis

Science.gov (United States)

McCaffrey, Thomas M.; Franklin, Steven E.

1993-11-01

A computer program is presented to select training sites automatically from remotely sensed digital imagery. The basic ideas are to guide the image analyst through the process of selecting typical and representative areas for large-area image classifications by minimizing bias, and to provide an initial list of potential classes for which training sites are required to develop a classification scheme or to verify classification accuracy. Reducing subjectivity in training site selection is achieved by using a purely statistical selection of homogeneous sites which then can be compared to field knowledge, aerial photography, or other remote-sensing imagery and ancillary data to arrive at a final selection of sites to be used to train the classification decision rules. The selection of the homogeneous sites uses simple tests based on the coefficient of variance, the F-statistic, and the Student's i-statistic. Comparisons of site means are conducted with a linear growing list of previously located homogeneous pixels. The program supports a common pixel-interleaved digital image format and has been tested on aerial and satellite optical imagery. The program is coded efficiently in the C programming language and was developed under AIX-Unix on an IBM RISC 6000 24-bit color workstation.

The use of bicycle workstations to increase physical activity in secondary classrooms

Directory of Open Access Journals (Sweden)

Alicia Fedewa

2017-11-01

Full Text Available Background To date, the majority of interventions have implemented classroom-based physical activity (PA at the elementary level; however, there is both the potential and need to explore student outcomes at high-school level as well, given that very few studies have incorporated classroom-based PA interventions for adolescents. One exception has been the use of bicycle workstations within secondary classrooms. Using bicycle workstations in lieu of traditional chairs in a high school setting shows promise for enhancing adolescents’ physical activity during the school day. Participants and procedure The present study explored the effects of integrating bicycle workstations into a secondary classroom setting for four months in a sample of 115 adolescents using an A-B-A-B withdrawal design. The study took place in one Advanced Placement English classroom across five groups of students. Physical activity outcomes included average heart rate, and caloric expenditure. Behavioural outcomes included percentage of on-task/off-task behaviour and number of teacher prompts in redirecting off-task behaviour. Feasibility and acceptability data of using the bicycle workstations were also collected. Results Findings showed significant improvements in physical activity as measured by heart rate and caloric expenditure, although heart rate percentage remained in the low intensity range when students were on the bicycle workstations. No effects were found on students’ on-task behaviour when using the bicycle workstations. Overall, students found the bikes acceptable to use but noted disadvantages of them as well. Conclusions Using bicycle workstations in high-school settings appears promising for enhancing low-intensity physical activity among adolescents. The limitations of the present study and implications for physical activity interventions in secondary schools are discussed.

Diagnostic image workstations ofr PACS

International Nuclear Information System (INIS)

Meyer-Ebrecht, D.; Fasel, B.; Dahm, M.; Kaupp, A.; Schilling, R.

1990-01-01

Image workstations will be the 'window' to the complex infrastructure of PACS with its intertwined image modalities (image sources, image data bases and image processing devices) and data processing modalities (patient data bases, departmental and hospital information systems). They will serve for user-to-system dialogues, image display and local processing of data as well as images. Their hardware and software structures have to be optimized towards an efficient throughput and processing of image data. (author). 10 refs

New control system for the KEK-linac

International Nuclear Information System (INIS)

Kamikubota, N.; Furukawa, K.; Nakahara, K.; Abe, I.; Akimoto, H.

1993-01-01

New control system for the KEK-Linac has been developed. Unix-based workstations and VME-bus computers are introduced. They are inter-connected with an Ethernet, which is used as a high-speed data-exchange network. New system will start the operation after October 1993. (author)

Office ergonomics: deficiencies in computer workstation design.

Science.gov (United States)

Shikdar, Ashraf A; Al-Kindi, Mahmoud A

2007-01-01

The objective of this research was to study and identify ergonomic deficiencies in computer workstation design in typical offices. Physical measurements and a questionnaire were used to study 40 workstations. Major ergonomic deficiencies were found in physical design and layout of the workstations, employee postures, work practices, and training. The consequences in terms of user health and other problems were significant. Forty-five percent of the employees used nonadjustable chairs, 48% of computers faced windows, 90% of the employees used computers more than 4 hrs/day, 45% of the employees adopted bent and unsupported back postures, and 20% used office tables for computers. Major problems reported were eyestrain (58%), shoulder pain (45%), back pain (43%), arm pain (35%), wrist pain (30%), and neck pain (30%). These results indicated serious ergonomic deficiencies in office computer workstation design, layout, and usage. Strategies to reduce or eliminate ergonomic deficiencies in computer workstation design were suggested.

SCWEB, Scientific Workstation Evaluation Benchmark

Energy Technology Data Exchange (ETDEWEB)

Raffenetti, R C [Computing Services-Support Services Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439 (United States)

1988-06-16

1 - Description of program or function: The SCWEB (Scientific Workstation Evaluation Benchmark) software includes 16 programs which are executed in a well-defined scenario to measure the following performance capabilities of a scientific workstation: implementation of FORTRAN77, processor speed, memory management, disk I/O, monitor (or display) output, scheduling of processing (multiprocessing), and scheduling of print tasks (spooling). 2 - Method of solution: The benchmark programs are: DK1, DK2, and DK3, which do Fourier series fitting based on spline techniques; JC1, which checks the FORTRAN function routines which produce numerical results; JD1 and JD2, which solve dense systems of linear equations in double- and single-precision, respectively; JD3 and JD4, which perform matrix multiplication in single- and double-precision, respectively; RB1, RB2, and RB3, which perform substantial amounts of I/O processing on files other than the input and output files; RR1, which does intense single-precision floating-point multiplication in a tight loop, RR2, which initializes a 512x512 integer matrix in a manner which skips around in the address space rather than initializing each consecutive memory cell in turn; RR3, which writes alternating text buffers to the output file; RR4, which evaluates the timer routines and demonstrates that they conform to the specification; and RR5, which determines whether the workstation is capable of executing a 4-megabyte program

UNIX at high energy physics Laboratories

International Nuclear Information System (INIS)

Silverman, Alan

1994-01-01

With more and more high energy physics Laboratories ''downsizing'' from large central proprietary mainframe computers towards distributed networks, usually involving UNIX operating systems, the need was expressed at the 1991 Computers in HEP (CHEP) Conference to create a group to consider the implications of this trend and perhaps work towards some common solutions to ease the transition for HEP users worldwide

Time synchronization algorithm of distributed system based on server time-revise and workstation self-adjust

International Nuclear Information System (INIS)

Zhou Shumin; Sun Yamin; Tang Bin

2007-01-01

In order to enhance the time synchronization quality of the distributed system, a time synchronization algorithm of distributed system based on server time-revise and workstation self-adjust is proposed. The time-revise cycle and self-adjust process is introduced in the paper. The algorithm reduces network flow effectively and enhances the quality of clock-synchronization. (authors)

Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9).

Science.gov (United States)

Fu, Qinqin; Yuan, Y Adam

2013-03-01

Intensive research interest has focused on small RNA-processing machinery and the RNA-induced silencing complex (RISC), key cellular machines in RNAi pathways. However, the structural mechanism regarding RISC assembly, the primary step linking small RNA processing and RNA-mediated gene silencing, is largely unknown. Human RNA helicase A (DHX9) was reported to function as an RISC-loading factor, and such function is mediated mainly by its dsRNA-binding domains (dsRBDs). Here, we report the crystal structures of human RNA helicase A (RHA) dsRBD1 and dsRBD2 domains in complex with dsRNAs, respectively. Structural analysis not only reveals higher siRNA duplex-binding affinity displayed by dsRBD1, but also identifies a crystallographic dsRBD1 pair of physiological significance in cooperatively recognizing dsRNAs. Structural observations are further validated by isothermal titration calorimetric (ITC) assay. Moreover, co-immunoprecipitation (co-IP) assay coupled with mutagenesis demonstrated that both dsRBDs are required for RISC association, and such association is mediated by dsRNA. Hence, our structural and functional efforts have revealed a potential working model for siRNA recognition by RHA tandem dsRBDs, and together they provide direct structural insights into RISC assembly facilitated by RHA.

Imaging workstations for computer-aided primatology: promises and pitfalls.

Science.gov (United States)

Vannier, M W; Conroy, G C

1989-01-01

In this paper, the application of biomedical imaging workstations to primatology will be explained and evaluated. The technological basis, computer hardware and software aspects, and the various uses of several types of workstations will all be discussed. The types of workstations include: (1) Simple - these display-only workstations, which function as electronic light boxes, have applications as terminals to picture archiving and communication (PAC) systems. (2) Diagnostic reporting - image-processing workstations that include the ability to perform straightforward manipulations of gray scale and raw data values will be considered for operations such as histogram equalization (whether adaptive or global), gradient edge finders, contour generation, and region of interest, as well as other related functions. (3) Manipulation systems - three-dimensional modeling and computer graphics with application to radiation therapy treatment planning, and surgical planning and evaluation will be considered. A technology of prime importance in the function of these workstations lies in communications and networking. The hierarchical organization of an electronic computer network and workstation environment with the interrelationship of simple, diagnostic reporting, and manipulation workstations to a coaxial or fiber optic network will be analyzed.

Simty: generalized SIMT execution on RISC-V

OpenAIRE

Collange , Sylvain

2017-01-01

International audience; We present Simty, a massively multi-threaded RISC-V processor core that acts as a proof of concept for dynamic inter-thread vector-ization at the micro-architecture level. Simty runs groups of scalar threads executing SPMD code in lockstep, and assembles SIMD instructions dynamically across threads. Unlike existing SIMD or SIMT processors like GPUs or vector processors, Simty vector-izes scalar general-purpose binaries. It does not involve any instruction set extension...

Next generation farms at Fermilab

International Nuclear Information System (INIS)

Cudzewicz, R., Giacchetti, L., Leininger, M., Levshina, T., Pasetes, R., Schweitzer, M., Wolbers, S.

1997-01-01

The current generation of UNIX farms at Fermilab are rapidly approaching the end of their useful life. The workstations were purchased during the years 1991-1992 and represented the most cost-effective computing available at that time. Acquisition of new workstations is being made to upgrade the UNIX farms for the purpose of providing large amounts of computing for reconstruction of data being collected at the 1996-1997 fixed-target run, as well as to provide simulation computing for CMS, the Auger project, accelerator calculations and other projects that require massive amounts of CPU. 4 refs., 1 fig., 2 tabs

Applications of the parallel computing system using network

International Nuclear Information System (INIS)

Ido, Shunji; Hasebe, Hiroki

1994-01-01

Parallel programming is applied to multiple processors connected in Ethernet. Data exchanges between tasks located in each processing element are realized by two ways. One is socket which is standard library on recent UNIX operating systems. Another is a network connecting software, named as Parallel Virtual Machine (PVM) which is a free software developed by ORNL, to use many workstations connected to network as a parallel computer. This paper discusses the availability of parallel computing using network and UNIX workstations and comparison between specialized parallel systems (Transputer and iPSC/860) in a Monte Carlo simulation which generally shows high parallelization ratio. (author)

Schizotypal Estimators in Adolescence: The Concurrent Validity of the RISC.

Science.gov (United States)

Rust, John; Chiu, Herbert

1988-01-01

Administered Minnesota Counseling Inventory and Rust Inventory of Schizotypal Cognition (RISC) to 174 adolescents in Hong Kong. Results showed that negative schizophrenic symptoms of social dysfunction and emotional instability as measured by Minnesota Counseling Inventory were positively and significantly correlated with positive schizotypal…

Design and analysis of wudu’ (ablution) workstation for elderly in Malaysia

Science.gov (United States)

Aman, A.; Dawal, S. Z. M.; Rahman, N. I. A.

2017-06-01

Wudu’ (Ablution) workstation is one of the facilities used by most Muslims in all categories. At present, there are numbers of design guidelines for praying facilities but still lacking on wudu’ (ablution) area specification especially or elderly. Thus, It is timely to develop an ergonomic wudu’ workstation for elderly to perform ablution independently and confidently. This study was conducted to design an ergonomic ablution unit for the Muslim’s elderly in Malaysia. An ablution workstation was designed based on elderly anthropometric dimensions and was then analyse using CATIA V5R21 for posture investigation using RULAs. The results of the study has identified significant anthropometric dimensions in designing wudu’ (ablution) workstation for elderly people. This study can be considered as preliminary study for the development of an ergonomic ablution design for elderly. This effort will become one of the significant social contributions to our elderly population in developing our nation holistically.

siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs.

Science.gov (United States)

Vickers, Timothy A; Crooke, Stanley T

2012-07-01

While most siRNAs induce sequence-specific target mRNA cleavage and degradation in a process mediated by Ago2/RNA-induced silencing complex (RISC), certain siRNAs have also been demonstrated to direct target RNA reduction through deadenylation and subsequent degradation of target transcripts in a process which involves Ago1/RISC and P-bodies. In the current study, we present data suggesting that a third class of siRNA exist, which are capable of promoting target RNA reduction that is independent of both Ago and RISC. These siRNAs bind the target messenger RNA at the polyA signal and are capable of redirecting a small amount of polyadenylation to downstream polyA sites when present, however, the majority of the activity appears to be due to inhibition of polyadenylation or deadenylation of the transcript, followed by exosomal degradation of the immature mRNA.

Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes.

Science.gov (United States)

Iwasaki, Shintaro; Kobayashi, Maki; Yoda, Mayuko; Sakaguchi, Yuriko; Katsuma, Susumu; Suzuki, Tsutomu; Tomari, Yukihide

2010-07-30

Small silencing RNAs--small interfering RNAs (siRNAs) or microRNAs (miRNAs)--direct posttranscriptional gene silencing of their mRNA targets as guides for the RNA-induced silencing complex (RISC). Both siRNAs and miRNAs are born double stranded. Surprisingly, loading these small RNA duplexes into Argonaute proteins, the core components of RISC, requires ATP, whereas separating the two small RNA strands within Argonaute does not. Here we show that the Hsc70/Hsp90 chaperone machinery is required to load small RNA duplexes into Argonaute proteins, but not for subsequent strand separation or target cleavage. We envision that the chaperone machinery uses ATP and mediates a conformational opening of Ago proteins so that they can receive bulky small RNA duplexes. Our data suggest that the chaperone machinery may serve as the driving force for the RISC assembly pathway. Copyright 2010 Elsevier Inc. All rights reserved.

RISC & DSP System Application Design using VHDL

OpenAIRE

Rachana Solanki; Vinay Gupta

2014-01-01

The Reduced Instruction Set Computer (RISC) processor use fewer instructions with simple constructs, therefore they can be executed much faster within the CPU without having to use memory as often. It reduce execution time by simplifying the instruction set of the computer. The DSP processors are perform the operation such as Discrete Cosine transform (DCT), Inverse DCT, Discrete Fourier Transform (DFT) and Fast Fourier Transform (FFT) are performed by DSP system. This paper represent the des...

Physics detector simulation facility system software description

International Nuclear Information System (INIS)

Allen, J.; Chang, C.; Estep, P.; Huang, J.; Liu, J.; Marquez, M.; Mestad, S.; Pan, J.; Traversat, B.

1991-12-01

Large and costly detectors will be constructed during the next few years to study the interactions produced by the SSC. Efficient, cost-effective designs for these detectors will require careful thought and planning. Because it is not possible to test fully a proposed design in a scaled-down version, the adequacy of a proposed design will be determined by a detailed computer model of the detectors. Physics and detector simulations will be performed on the computer model using high-powered computing system at the Physics Detector Simulation Facility (PDSF). The SSCL has particular computing requirements for high-energy physics (HEP) Monte Carlo calculations for the simulation of SSCL physics and detectors. The numerical calculations to be performed in each simulation are lengthy and detailed; they could require many more months per run on a VAX 11/780 computer and may produce several gigabytes of data per run. Consequently, a distributed computing environment of several networked high-speed computing engines is envisioned to meet these needs. These networked computers will form the basis of a centralized facility for SSCL physics and detector simulation work. Our computer planning groups have determined that the most efficient, cost-effective way to provide these high-performance computing resources at this time is with RISC-based UNIX workstations. The modeling and simulation application software that will run on the computing system is usually written by physicists in FORTRAN language and may need thousands of hours of supercomputing time. The system software is the ''glue'' which integrates the distributed workstations and allows them to be managed as a single entity. This report will address the computing strategy for the SSC

CEBAF control system

International Nuclear Information System (INIS)

Bork, R.; Grubb, C.; Lahti, G.; Navarro, E.; Sage, J.

1989-01-01

A logic-based computer control system is in development at CEBAF. This Unix/C language software package, running on a distributed, hierarchical system of workstation and supervisory minicomputers, interfaces to hardware via CAMAC. Software aspects to be covered are ladder logic, interactive database generation, networking, and graphic user interfaces. 1 fig

The safety monitor and RCM workstation as complementary tools in risk based maintenance optimization

International Nuclear Information System (INIS)

Rawson, P.D.

2000-01-01

Reliability Centred Maintenance (RCM) represents a proven technique for rendering maintenance activities safer, more effective, and less expensive, in terms of systems unavailability and resource management. However, it is believed that RCM can be enhanced by the additional consideration of operational plant risk. This paper discusses how two computer-based tools, i.e., the RCM Workstation and the Safety Monitor, can complement each other in helping to create a living preventive maintenance strategy. (author)

ADAM (Affordable Desktop Application Manager): a Unix desktop application manager

International Nuclear Information System (INIS)

Liebana, M.; Marquina, M.; Ramos, R.

1996-01-01

ADAM stands for Affordable Desktop Application Manager. It is a GUI developed at CERN with the aim to ease access to applications. The motivation to develop ADAM came from the unavailability of environments like COSE/CDE and their heavy resource consumption. ADAM has proven to be user friendly: new users are able to customize it to their needs in few minutes. Groups of users may share through ADAM a common application environment. ADAM also integrates the Unix and the PC world. PC users can excess Unix applications in the same way as their usual Windows applications. This paper describes all the ADAM features, how they are used at CERN Public Services, and the future plans for ADAM. (author)

FASTRAN II - FATIGUE CRACK GROWTH STRUCTURAL ANALYSIS (UNIX VERSION)

Science.gov (United States)

Newman, J. C.

1994-01-01

Predictions of fatigue crack growth behavior can be made with the Fatigue Crack Growth Structural Analysis (FASTRAN II) computer program. As cyclic loads are applied to a selected crack configuration with an initial crack size, FASTRAN II predicts crack growth as a function of cyclic load history until either a desired crack size is reached or failure occurs. FASTRAN II is based on plasticity-induced crack-closure behavior of cracks in metallic materials and accounts for load-interaction effects, such as retardation and acceleration, under variable-amplitude loading. The closure model is based on the Dugdale model with modifications to allow plastically deformed material to be left along the crack surfaces as the crack grows. Plane stress and plane strain conditions, as well as conditions between these two, can be simulated in FASTRAN II by using a constraint factor on tensile yielding at the crack front to approximately account for three-dimensional stress states. FASTRAN II contains seventeen predefined crack configurations (standard laboratory fatigue crack growth rate specimens and many common crack configurations found in structures); and the user can define one additional crack configuration. The baseline crack growth rate properties (effective stress-intensity factor against crack growth rate) may be given in either equation or tabular form. For three-dimensional crack configurations, such as surface cracks or corner cracks at holes or notches, the fatigue crack growth rate properties may be different in the crack depth and crack length directions. Final failure of the cracked structure can be modelled with fracture toughness properties using either linear-elastic fracture mechanics (brittle materials), a two-parameter fracture criterion (brittle to ductile materials), or plastic collapse (extremely ductile materials). The crack configurations in FASTRAN II can be subjected to either constant-amplitude, variable-amplitude or spectrum loading. The applied

Zoning and workstation analysis in interventional cardiology

International Nuclear Information System (INIS)

Degrange, J.P.

2009-01-01

As interventional cardiology can induce high doses not only for patients but also for the personnel, the delimitation of regulated areas (or zoning) and workstation analysis (dosimetry) are very important in terms of radioprotection. This paper briefly recalls methods and tools for the different steps to perform zoning and workstation analysis. It outlines the peculiarities of interventional cardiology, presents methods and tools adapted to interventional cardiology, and then discusses the same issues but for workstation analysis. It also outlines specific problems which can be met, and their possible adapted solutions

High-performance computing — an overview

Science.gov (United States)

Marksteiner, Peter

1996-08-01

An overview of high-performance computing (HPC) is given. Different types of computer architectures used in HPC are discussed: vector supercomputers, high-performance RISC processors, various parallel computers like symmetric multiprocessors, workstation clusters, massively parallel processors. Software tools and programming techniques used in HPC are reviewed: vectorizing compilers, optimization and vector tuning, optimization for RISC processors; parallel programming techniques like shared-memory parallelism, message passing and data parallelism; and numerical libraries.

General specifications for the development of a USL/DBMS NASA/PC R and D distributed workstation

Science.gov (United States)

Dominick, Wayne D. (Editor); Chum, Frank Y.

1984-01-01

The general specifications for the development of a PC-based distributed workstation (PCDWS) for an information storage and retrieval systems environment are defined. This research proposes the development of a PCDWS prototype as part of the University of Southwestern Louisiana Data Base Management System (USL/DBMS) NASA/PC R and D project in the PC-based workstation environment.

Insulation coordination workstation for AC and DC substations

International Nuclear Information System (INIS)

Booth, R.R.; Hileman, A.R.

1990-01-01

The Insulation Coordination Workstation was designed to aid the substation design engineer in the insulation coordination process. The workstation utilizes state of the art computer technology to present a set of tools necessary for substation insulation coordination, and to support the decision making process for all aspects of insulation coordination. The workstation is currently being developed for personal computers supporting OS/2 Presentation Manager. Modern Computer-Aided Software Engineering (CASE) technology was utilized to create an easily expandable framework which currently consists of four modules, each accessing a central application database. The heart of the workstation is a library of user-friendly application programs for the calculation of important voltage stresses used for the evaluation of insulation coordination. The Oneline Diagram is a graphic interface for data entry into the EPRI distributed EMTP program, which allows the creation of complex systems on the CRT screen using simple mouse clicks and keyboard entries. Station shielding is graphically represented in the Geographic Viewport using a three-dimensional substation model, and the interactive plotting package allows plotting of EPRI EMTP output results on the CRT screen, printer, or pen plotter. The Insulation Coordination Workstation was designed by Advanced Systems Technology (AST), a division of ABB Power Systems, Inc., and sponsored by the Electric Power Research Institute under RP 2323-5, AC/DC Insulation Coordination Workstation

Balanç benefici/risc del contingut en polifenols i alcohol del vi: bases científiques dels efectes del consum moderat de vi sobre el sistema cardiovascular

OpenAIRE

Chiva Blanch, Gemma

2013-01-01

[cat] L'objectiu d'aquesta tesi doctoral és avaluar els efectes de les fraccions del vi (alcohòlica i no alcohòlica -principalment polifenols-) sobre els principals factors de risc cardiovascular en 67 homes amb un elevat risc de patir malalties cardiovasculars. Es va realitzar un assaig clínic, aleatoritzat i creuat en el qual tots els participants van rebre en un ordre aleatori les tres intervencions: 30 gr d'alcohol / dia en forma de vi negre, la mateixa quantitat de polifenols en forma de...

MULTITASKER, Multitasking Kernel for C and FORTRAN Under UNIX

International Nuclear Information System (INIS)

Brooks, E.D. III

1988-01-01

1 - Description of program or function: MULTITASKER implements a multitasking kernel for the C and FORTRAN programming languages that runs under UNIX. The kernel provides a multitasking environment which serves two purposes. The first is to provide an efficient portable environment for the development, debugging, and execution of production multiprocessor programs. The second is to provide a means of evaluating the performance of a multitasking program on model multiprocessor hardware. The performance evaluation features require no changes in the application program source and are implemented as a set of compile- and run-time options in the kernel. 2 - Method of solution: The FORTRAN interface to the kernel is identical in function to the CRI multitasking package provided for the Cray XMP. This provides a migration path to high speed (but small N) multiprocessors once the application has been coded and debugged. With use of the UNIX m4 macro preprocessor, source compatibility can be achieved between the UNIX code development system and the target Cray multiprocessor. The kernel also provides a means of evaluating a program's performance on model multiprocessors. Execution traces may be obtained which allow the user to determine kernel overhead, memory conflicts between various tasks, and the average concurrency being exploited. The kernel may also be made to switch tasks every cpu instruction with a random execution ordering. This allows the user to look for unprotected critical regions in the program. These features, implemented as a set of compile- and run-time options, cause extra execution overhead which is not present in the standard production version of the kernel

The role of the mainframe terminated : mainframe versus workstation

CERN Document Server

Williams, D O

1991-01-01

I. What mainframes? - The surgeon-general has determined that you shall treat all costs with care ( continental effects, discounts assumed, next month's or last month's prices, optimism of the reporter. II. Typical mainframe hardware III. Typical mainframe software IV. What workstations? VI. Typical workstation hardware VII. Typical workstation software VIII. Titan vs PDP-7s XIX.Historic answer X. Amdahl's Law....

RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators.

Science.gov (United States)

Redfern, Andrew D; Colley, Shane M; Beveridge, Dianne J; Ikeda, Naoya; Epis, Michael R; Li, Xia; Foulds, Charles E; Stuart, Lisa M; Barker, Andrew; Russell, Victoria J; Ramsay, Kerry; Kobelke, Simon J; Li, Xiaotao; Hatchell, Esme C; Payne, Christine; Giles, Keith M; Messineo, Adriana; Gatignol, Anne; Lanz, Rainer B; O'Malley, Bert W; Leedman, Peter J

2013-04-16

The cytoplasmic RNA-induced silencing complex (RISC) contains dsRNA binding proteins, including protein kinase RNA activator (PACT), transactivation response RNA binding protein (TRBP), and Dicer, that process pre-microRNAs into mature microRNAs (miRNAs) that target specific mRNA species for regulation. There is increasing evidence for important functional interactions between the miRNA and nuclear receptor (NR) signaling networks, with recent data showing that estrogen, acting through the estrogen receptor, can modulate initial aspects of nuclear miRNA processing. Here, we show that the cytoplasmic RISC proteins PACT, TRBP, and Dicer are steroid receptor RNA activator (SRA) binding NR coregulators that target steroid-responsive promoters and regulate NR activity and downstream gene expression. Furthermore, each of the RISC proteins, together with Argonaute 2, associates with SRA and specific pre-microRNAs in both the nucleus and cytoplasm, providing evidence for links between NR-mediated transcription and some of the factors involved in miRNA processing.

Competition between alliance blocks : the case of the RISC microprocessor technology

NARCIS (Netherlands)

Vanhaverbeke, W.P.M.; Noorderhaven, N.G.

2001-01-01

Competition between alliance blocks is a new form of rivalry: groups of firms link together for a common purpose by means of strategic alliances, and competition between alliance blocks is superimposed on competition between individual firms. This paper focuses on alliance blocks in the RISC

Evaluating biomechanics of user-selected sitting and standing computer workstation.

Science.gov (United States)

Lin, Michael Y; Barbir, Ana; Dennerlein, Jack T

2017-11-01

A standing computer workstation has now become a popular modern work place intervention to reduce sedentary behavior at work. However, user's interaction related to a standing computer workstation and its differences with a sitting workstation need to be understood to assist in developing recommendations for use and set up. The study compared the differences in upper extremity posture and muscle activity between user-selected sitting and standing workstation setups. Twenty participants (10 females, 10 males) volunteered for the study. 3-D posture, surface electromyography, and user-reported discomfort were measured while completing simulated tasks with each participant's self-selected workstation setups. Sitting computer workstation associated with more non-neutral shoulder postures and greater shoulder muscle activity, while standing computer workstation induced greater wrist adduction angle and greater extensor carpi radialis muscle activity. Sitting computer workstation also associated with greater shoulder abduction postural variation (90th-10th percentile) while standing computer workstation associated with greater variation for should rotation and wrist extension. Users reported similar overall discomfort levels within the first 10 min of work but had more than twice as much discomfort while standing than sitting after 45 min; with most discomfort reported in the low back for standing and shoulder for sitting. These different measures provide understanding in users' different interactions with sitting and standing and by alternating between the two configurations in short bouts may be a way of changing the loading pattern on the upper extremity. Copyright © 2017 Elsevier Ltd. All rights reserved.

A Next Generation BioPhotonics Workstation

DEFF Research Database (Denmark)

Glückstad, Jesper; Palima, Darwin; Tauro, Sandeep

2011-01-01

We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials.......We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials....

Radiology workstation for mammography: preliminary observations, eyetracker studies, and design

Science.gov (United States)

Beard, David V.; Johnston, Richard E.; Pisano, Etta D.; Hemminger, Bradley M.; Pizer, Stephen M.

1991-07-01

For the last four years, the UNC FilmPlane project has focused on constructing a radiology workstation facilitating CT interpretations equivalent to those with film and viewbox. Interpretation of multiple CT studies was originally chosen because handling such large numbers of images was considered to be one of the most difficult tasks that could be performed with a workstation. The authors extend the FilmPlane design to address mammography. The high resolution and contrast demands coupled with the number of images often cross- compared make mammography a difficult challenge for the workstation designer. This paper presents the results of preliminary work with workstation interpretation of mammography. Background material is presented to justify why the authors believe electronic mammographic workstations could improve health care delivery. The results of several observation sessions and a preliminary eyetracker study of multiple-study mammography interpretations are described. Finally, tentative conclusions of what a mammographic workstation might look like and how it would meet clinical demand to be effective are presented.

The Impact of Ergonomically Designed Workstations on Shoulder EMG Activity during Carpet Weaving

Directory of Open Access Journals (Sweden)

Majid Motamedzade

2014-12-01

Full Text Available Background: The present study aimed to evaluate the biomechanical exposure to the trapezius muscle activity in female weavers for a prolonged period in the workstation A (suggested by previous studies and workstation B (proposed by the present study. Methods: Electromyography data were collected from nine females during four hours for each ergonomically designed workstation at the Ergonomics Laboratory, Hamadan, Iran. The design criteria for ergonomically designed workstations were: 1 weaving height (20 and 3 cm above elbow height for workstations A and B, respectively, and 2 seat type (10° and 0° forwardsloping seat for workstations A and B, respectively. Results: The amplitude probability distribution function (APDF analysis showed that the left and right upper trapezius muscle activity was almost similar at each workstation. Trapezius muscle activity in the workstation A was significantly greater than workstations B (P<0.001. Conclusion: In general, use of workstation B leads to significantly reduced muscle activity levels in the upper trapezius as compared to workstation A in weavers. Despite the positive impact of workstation B in reducing trapezius muscle activity, it seems that constrained postures of the upper arm during weaving may be associated with musculoskeletal symptoms.

The ALICE Magnetic System Computation.

CERN Document Server

Klempt, W; CERN. Geneva; Swoboda, Detlef

1995-01-01

In this note we present the first results from the ALICE magnetic system computation performed in the 3-dimensional way with the Vector Fields TOSCA code (version 6.5) [1]. To make the calculations we have used the IBM RISC System 6000-370 and 6000-550 machines combined in the CERN PaRC UNIX cluster.

A UNIX device driver for a Translink II Transputer board

International Nuclear Information System (INIS)

Wiley, J.C.

1991-01-01

A UNIX device driver for a TransLink II Transputer board is described. A complete listing of the code is presented. The device driver allows a transputer array to be used with the A/UX operating system

CAMAC throughput of a new RISC-based data acquisition computer at the DIII-D tokamak

International Nuclear Information System (INIS)

VanderLaan, J.F.; Cummings, J.W.

1993-10-01

The amount of experimental data acquired per plasma discharge at DIII-D has continued to grow. The largest shot size in May 1991 was 49 Mbyte; in May 1992, 66 Mbyte; and in April 1993, 80 Mbyte. The increasing load has prompted the installation of a new Motorola 88100-based MODCOMP computer to supplement the existing core of three older MODCOMP data acquisition CPUs. New Kinetic Systems CAMAC serial highway driver hardware runs on the 88100 VME bus. The new operating system is MODCOMP REAL/IX version of AT ampersand T System V UNIX with real-time extensions and networking capabilities; future plans call for installation of additional computers of this type for tokamak and neutral beam control functions. Experiences with the CAMAC hardware and software will be chronicled, including observation of data throughput. The Enhanced Serial Highway crate controller is advertised as twice as fast as the previous crate controller, and computer I/O speeds are expected to also increase data rates

CAMAC throughput of a new RISC-based data acquisition computer at the DIII-D tokamak

Science.gov (United States)

Vanderlaan, J. F.; Cummings, J. W.

1993-10-01

The amount of experimental data acquired per plasma discharge at DIII-D has continued to grow. The largest shot size in May 1991 was 49 Mbyte; in May 1992, 66 Mbyte; and in April 1993, 80 Mbyte. The increasing load has prompted the installation of a new Motorola 88100-based MODCOMP computer to supplement the existing core of three older MODCOMP data acquisition CPU's. New Kinetic Systems CAMAC serial highway driver hardware runs on the 88100 VME bus. The new operating system is MODCOMP REAL/IX version of AT&T System V UNIX with real-time extensions and networking capabilities; future plans call for installation of additional computers of this type for tokamak and neutral beam control functions. Experiences with the CAMAC hardware and software will be chronicled, including observation of data throughput. The Enhanced Serial Highway crate controller is advertised as twice as fast as the previous crate controller, and computer I/O speeds are expected to also increase data rates.

Single-molecule fluorescence measurements reveal the reaction mechanisms of the core RISC, composed of human Argonaute 2 and a guide RNA.

Science.gov (United States)

Jo, Myung Hyun; Song, Ji-Joon; Hohng, Sungchul

2015-12-01

In eukaryotes, small RNAs play important roles in both gene regulation and resistance to viral infection. Argonaute proteins have been identified as a key component of the effector complexes of various RNA-silencing pathways, but the mechanistic roles of Argonaute proteins in these pathways are not clearly understood. To address this question, we performed single-molecule fluorescence experiments using an RNA-induced silencing complex (core-RISC) composed of a small RNA and human Argonaute 2. We found that target binding of core-RISC starts at the seed region of the guide RNA. After target binding, four distinct reactions followed: target cleavage, transient binding, stable binding, and Argonaute unloading. Target cleavage required extensive sequence complementarity and accelerated core-RISC dissociation for recycling. In contrast, the stable binding of core-RISC to target RNAs required seed-match only, suggesting a potential explanation for the seed-match rule of microRNA (miRNA) target selection.

UNIX-a solution to the compatibility problem

International Nuclear Information System (INIS)

Gulbranson, R.L.

1983-01-01

The UNIX operating system (TM Bell Laboratories) has achieved a high degree of popularity in recent years. It is rapidly becoming a defacto standard as the operating system for 16 and 32 bit microcomputers. The adoption of this operating system by the physics community offers several substantial advantages; a portable software environment (editors, file system, etc.), freedom to choose among a variety of higher-level languages for software applications, and computer hardware vendor independence

Physics analysis workstation

International Nuclear Information System (INIS)

Johnstad, H.

1989-06-01

The Physics Analysis Workstation (PAW) is a high-level program providing data presentation and statistical or mathematical analysis. PAW has been developed at CERN as an instrument to assist physicists in the analysis and presentation of their data. The program is interfaced to a high level graphics package, based on basic underlying graphics. 3-D graphics capabilities are being implemented. The major objects in PAW are 1 or 2 dimensional binned event data with fixed number of entries per event, vectors, functions, graphics pictures, and macros. Command input is handled by an integrated user interface package, which allows for a variety of choices for input, either with typed commands, or in a tree structure menu driven mode. 6 refs., 1 fig

Post-deployment usability evaluation of a radiology workstation

NARCIS (Netherlands)

Jorritsma, Wiard; Cnossen, Fokie; Dierckx, Rudi A.; Oudkerk, Matthijs; Van Ooijen, Peter M. A.

Objectives: To determine the number, nature and severity of usability issues radiologists encounter while using a commercially available radiology workstation in clinical practice, and to assess how well the results of a pre-deployment usability evaluation of this workstation generalize to clinical

Arabidopsis ARGONAUTE7 selects miR390 through multiple checkpoints during RISC assembly.

Science.gov (United States)

Endo, Yayoi; Iwakawa, Hiro-oki; Tomari, Yukihide

2013-07-01

Plant ARGONAUTE7 (AGO7) assembles RNA-induced silencing complex (RISC) specifically with miR390 and regulates the auxin-signalling pathway via production of TAS3 trans-acting siRNAs (tasiRNAs). However, how AGO7 discerns miR390 among other miRNAs remains unclear. Here, we show that the 5' adenosine of miR390 and the central region of miR390/miR390* duplex are critical for the specific interaction with AGO7. Furthermore, despite the existence of mismatches in the seed and central regions of the duplex, cleavage of the miR390* strand is required for maturation of AGO7-RISC. These findings suggest that AGO7 uses multiple checkpoints to select miR390, thereby circumventing promiscuous tasiRNA production.

RISC-mediated control of selected chromatin regulators stabilizes ground state pluripotency of mouse embryonic stem cells.

Science.gov (United States)

Pandolfini, Luca; Luzi, Ettore; Bressan, Dario; Ucciferri, Nadia; Bertacchi, Michele; Brandi, Rossella; Rocchiccioli, Silvia; D'Onofrio, Mara; Cremisi, Federico

2016-05-06

Embryonic stem cells are intrinsically unstable and differentiate spontaneously if they are not shielded from external stimuli. Although the nature of such instability is still controversial, growing evidence suggests that protein translation control may play a crucial role. We performed an integrated analysis of RNA and proteins at the transition between naïve embryonic stem cells and cells primed to differentiate. During this transition, mRNAs coding for chromatin regulators are specifically released from translational inhibition mediated by RNA-induced silencing complex (RISC). This suggests that, prior to differentiation, the propensity of embryonic stem cells to change their epigenetic status is hampered by RNA interference. The expression of these chromatin regulators is reinstated following acute inactivation of RISC and it correlates with loss of stemness markers and activation of early cell differentiation markers in treated embryonic stem cells. We propose that RISC-mediated inhibition of specific sets of chromatin regulators is a primary mechanism for preserving embryonic stem cell pluripotency while inhibiting the onset of embryonic developmental programs.

Computer-aided diagnosis workstation and database system for chest diagnosis based on multi-helical CT images

Science.gov (United States)

Satoh, Hitoshi; Niki, Noboru; Mori, Kiyoshi; Eguchi, Kenji; Kaneko, Masahiro; Kakinuma, Ryutarou; Moriyama, Noriyuki; Ohmatsu, Hironobu; Masuda, Hideo; Machida, Suguru; Sasagawa, Michizou

2006-03-01

Multi-helical CT scanner advanced remarkably at the speed at which the chest CT images were acquired for mass screening. Mass screening based on multi-helical CT images requires a considerable number of images to be read. It is this time-consuming step that makes the use of helical CT for mass screening impractical at present. To overcome this problem, we have provided diagnostic assistance methods to medical screening specialists by developing a lung cancer screening algorithm that automatically detects suspected lung cancers in helical CT images and a coronary artery calcification screening algorithm that automatically detects suspected coronary artery calcification. We also have developed electronic medical recording system and prototype internet system for the community health in two or more regions by using the Virtual Private Network router and Biometric fingerprint authentication system and Biometric face authentication system for safety of medical information. Based on these diagnostic assistance methods, we have now developed a new computer-aided workstation and database that can display suspected lesions three-dimensionally in a short time. This paper describes basic studies that have been conducted to evaluate this new system. The results of this study indicate that our computer-aided diagnosis workstation and network system can increase diagnostic speed, diagnostic accuracy and safety of medical information.

Viral RNAi suppressor reversibly binds siRNA to outcompete Dicer and RISC via multiple turnover.

Science.gov (United States)

Rawlings, Renata A; Krishnan, Vishalakshi; Walter, Nils G

2011-04-29

RNA interference is a conserved gene regulatory mechanism employed by most eukaryotes as a key component of their innate immune response to viruses and retrotransposons. During viral infection, the RNase-III-type endonuclease Dicer cleaves viral double-stranded RNA into small interfering RNAs (siRNAs) 21-24 nucleotides in length and helps load them into the RNA-induced silencing complex (RISC) to guide the cleavage of complementary viral RNA. As a countermeasure, many viruses have evolved viral RNA silencing suppressors (RSS) that tightly, and presumably quantitatively, bind siRNAs to thwart RNA-interference-mediated degradation. Viral RSS proteins also act across kingdoms as potential immunosuppressors in gene therapeutic applications. Here we report fluorescence quenching and electrophoretic mobility shift assays that probe siRNA binding by the dimeric RSS p19 from Carnation Italian Ringspot Virus, as well as by human Dicer and RISC assembly complexes. We find that the siRNA:p19 interaction is readily reversible, characterized by rapid binding [(1.69 ± 0.07) × 10(8) M(-)(1) s(-1)] and marked dissociation (k(off)=0.062 ± 0.002 s(-1)). We also observe that p19 efficiently competes with recombinant Dicer and inhibits the formation of RISC-related assembly complexes found in human cell extract. Computational modeling based on these results provides evidence for the transient formation of a ternary complex between siRNA, human Dicer, and p19. An expanded model of RNA silencing indicates that multiple turnover by reversible binding of siRNAs potentiates the efficiency of the suppressor protein. Our predictive model is expected to be applicable to the dosing of p19 as a silencing suppressor in viral gene therapy. Copyright © 2011 Elsevier Ltd. All rights reserved.

Viral RNAi suppressor reversibly binds siRNA to outcompete Dicer and RISC via multiple-turnover

Science.gov (United States)

Rawlings, Renata A.; Krishnan, Vishalakshi; Walter, Nils G.

2011-01-01

RNA interference (RNAi) is a conserved gene regulatory mechanism employed by most eukaryotes as a key component of their innate immune response against viruses and retrotransposons. During viral infection, the RNase III-type endonuclease Dicer cleaves viral double-stranded RNA into small interfering RNAs (siRNAs), 21–24 nucleotides in length, and helps load them into the RNA-induced silencing complex (RISC) to guide cleavage of complementary viral RNA. As a countermeasure, many viruses have evolved viral RNA silencing suppressor (RSS) proteins that tightly, and presumably quantitatively, bind siRNAs to thwart RNAi-mediated degradation. Viral RSS proteins also act across kingdoms as potential immunosuppressors in gene therapeutic applications. Here we report fluorescence quenching and electrophoretic mobility shift assays that probe siRNA binding by the dimeric RSS p19 from Carnation Italian Ringspot Virus (CIRV), as well as by human Dicer and RISC assembly complexes. We find that the siRNA:p19 interaction is readily reversible, characterized by rapid binding ((1.69 ± 0.07)×108 M−1s−1) and marked dissociation (koff = 0.062 ± 0.002 s−1). We also observe that p19 efficiently competes with recombinant Dicer and inhibits formation of RISC-related assembly complexes found in human cell extract. Computational modeling based on these results provides evidence for the transient formation of a ternary complex between siRNA, human Dicer, and p19. An expanded model of RNA silencing indicates that multiple-turnover by reversible binding of siRNAs potentiates the efficiency of the suppressor protein. Our predictive model is expected to be applicable to the dosing of p19 as a silencing suppressor in viral gene therapy. PMID:21354178

An Advanced Commanding and Telemetry System

Science.gov (United States)

Hill, Maxwell G. G.

The Loral Instrumentation System 500 configured as an Advanced Commanding and Telemetry System (ACTS) supports the acquisition of multiple telemetry downlink streams, and simultaneously supports multiple uplink command streams for today's satellite vehicles. By using industry and federal standards, the system is able to support, without relying on a host computer, a true distributed dataflow architecture that is complemented by state-of-the-art RISC-based workstations and file servers.

Experimental study of heavy flavor physics and SSC research and development at the University of Mississippi

International Nuclear Information System (INIS)

Reidy, J.J.; Cremaldi, L.M.; Summers, D.J.

1992-01-01

The High Energy Physics Group has been principally involved with Fermilab experiments on photoproduction and hadroproduction of charm. Nuclear reactions with a mixed 250-GeV hadronic beam and 500-GeV π-N interactions were used. Considerable attention is devoted to the UNIX/RISC computing farm. The Group also has an SSC R ampersand D program dealing with the adaptation and use of the HETC-based detector simulation code CALOR89, the development of liquid scintillator technology for use in SSC detector calorimeters, the hanging file calorimeter project, and the calorimetry program for GEM

[Design and development of the DSA digital subtraction workstation].

Science.gov (United States)

Peng, Wen-Xian; Peng, Tian-Zhou; Xia, Shun-Ren; Jin, Guang-Bo

2008-05-01

According to the patient examination criterion and the demands of all related departments, the DSA digital subtraction workstation has been successfully designed and is introduced in this paper by analyzing the characteristic of video source of DSA which was manufactured by GE Company and has no DICOM standard interface. The workstation includes images-capturing gateway and post-processing software. With the developed workstation, all images from this early DSA equipment are transformed into DICOM format and then are shared in different machines.

Concurrent use of data base and graphics computer workstations to provide graphic access to large, complex data bases for robotics control of nuclear surveillance and maintenance

International Nuclear Information System (INIS)

Dalton, G.R.; Tulenko, J.S.; Zhou, X.

1990-01-01

The University of Florida is part of a multiuniversity research effort, sponsored by the US Department of Energy which is under way to develop and deploy an advanced semi-autonomous robotic system for use in nuclear power stations. This paper reports on the development of the computer tools necessary to gain convenient graphic access to the intelligence implicit in a large complex data base such as that in a nuclear reactor plant. This program is integrated as a man/machine interface within the larger context of the total computerized robotic planning and control system. The portion of the project described here addresses the connection between the three-dimensional displays on an interactive graphic workstation and a data-base computer running a large data-base server program. Programming the two computers to work together to accept graphic queries and return answers on the graphic workstation is a key part of the interactive capability developed

Workstations studies and radiation protection; Etudes de postes et radioprotection

Energy Technology Data Exchange (ETDEWEB)

Lahaye, T. [Direction des relations du travail, 75 - Paris (France); Donadille, L.; Rehel, J.L.; Paquet, F. [Institut de Radioprotection et de Surete Nucleaire, 92 - Fontenay-aux-Roses (France); Beneli, C. [Paris-5 Univ., 75 (France); Cordoliani, Y.S. [Societe Francaise de Radioprotection, 92 - Fontenay-aux-Roses (France); Vrigneaud, J.M. [Assistance Publique - Hopitaux de Paris, 75 (France); Gauron, C. [Institut National de Recherche et de Securite, 75 - Paris (France); Petrequin, A.; Frison, D. [Association des Medecins du Travail des Salaries du Nucleaire (France); Jeannin, B. [Electricite de France (EDF), 75 - Paris (France); Charles, D. [Polinorsud (France); Carballeda, G. [cabinet Indigo Ergonomie, 33 - Merignac (France); Crouail, P. [Centre d' Etude sur l' Evaluation de la Protection dans le Domaine Nucleaire, 92 - Fontenay-aux-Roses (France); Valot, C. [IMASSA, 91 - Bretigny-sur-Orge (France)

2006-07-01

This day on the workstations studies for the workers follow-up, was organised by the research and health section. Devoted to the company doctors, for the competent persons in radiation protection, for the engineers of safety, it presented examples of methodologies and applications in the medical, industrial domain and the research, so contributing to a better understanding and an application of regulatory measures. The analysis of the workstation has to allow a reduction of the exposures and the risks and lead to the optimization of the medical follow-up. The agenda of this day included the different subjects as follow: evolution of the regulation in matter of demarcation of the regulated zones where the measures of workers protection are strengthened; presentation of the I.R.S.N. guide of help to the realization of a workstation study; implementation of a workstation study: case of radiology; the workstation studies in the research area; Is it necessary to impose the operational dosimetry in the services of radiodiagnostic? The experience feedback of a competent person in radiation protection (P.C.R.) in a hospital environment; radiation protection: elaboration of a good practices guide in medical field; the activities file in nuclear power plant: an evaluation tool of risks for the prevention. Methodological presentation and examples; insulated workstation study; the experience feedback of a provider; Contribution of the ergonomics to the determiners characterization in the ionizing radiation exposure situations;The workstations studies for the internal contamination in the fuel cycle facilities and the consideration of the results in the medical follow-up; R.E.L.I.R. necessity of workstation studies; the consideration of the human factor. (N.C.)

The Temple Translator's Workstation Project

National Research Council Canada - National Science Library

Vanni, Michelle; Zajac, Remi

1996-01-01

.... The Temple Translator's Workstation is incorporated into a Tipster document management architecture and it allows both translator/analysts and monolingual analysts to use the machine- translation...

Polerovirus protein P0 prevents the assembly of small RNA-containing RISC complexes and leads to degradation of ARGONAUTE1.

Science.gov (United States)

Csorba, Tibor; Lózsa, Rita; Hutvágner, György; Burgyán, József

2010-05-01

RNA silencing plays an important role in plants in defence against viruses. To overcome this defence, plant viruses encode suppressors of RNA silencing. The most common mode of silencing suppression is sequestration of double-stranded RNAs involved in the antiviral silencing pathways. Viral suppressors can also overcome silencing responses through protein-protein interaction. The poleroviral P0 silencing suppressor protein targets ARGONAUTE (AGO) proteins for degradation. AGO proteins are the core component of the RNA-induced silencing complex (RISC). We found that P0 does not interfere with the slicer activity of pre-programmed siRNA/miRNA containing AGO1, but prevents de novo formation of siRNA/miRNA containing AGO1. We show that the AGO1 protein is part of a high-molecular-weight complex, suggesting the existence of a multi-protein RISC in plants. We propose that P0 prevents RISC assembly by interacting with one of its protein components, thus inhibiting formation of siRNA/miRNA-RISC, and ultimately leading to AGO1 degradation. Our findings also suggest that siRNAs enhance the stability of co-expressed AGO1 in both the presence and absence of P0.

A Network SIG is born, DECUS (Switzerland) Newsletter, May 1990

CERN Document Server

Heagerty, Denise

1990-01-01

This article announces the formation of a Swiss DECUS (DEC Users Group) Network SIG in May 1990. The goal of this SIG is to help Swiss DECnet managers to plan transition from their proprietary DECnet Phase IV networks (e.g. the HEP/SPAN DECnet) to open networks based on DECnet Phase V/OSI. The SIG also proposes to address integration with UNIX based workstations using the Internet's TCP/IP protocols.

Workplace sitting and height-adjustable workstations: a randomized controlled trial.

Science.gov (United States)

Neuhaus, Maike; Healy, Genevieve N; Dunstan, David W; Owen, Neville; Eakin, Elizabeth G

2014-01-01

Desk-based office employees sit for most of their working day. To address excessive sitting as a newly identified health risk, best practice frameworks suggest a multi-component approach. However, these approaches are resource intensive and knowledge about their impact is limited. To compare the efficacy of a multi-component intervention to reduce workplace sitting time, to a height-adjustable workstations-only intervention, and to a comparison group (usual practice). Three-arm quasi-randomized controlled trial in three separate administrative units of the University of Queensland, Brisbane, Australia. Data were collected between January and June 2012 and analyzed the same year. Desk-based office workers aged 20-65 (multi-component intervention, n=16; workstations-only, n=14; comparison, n=14). The multi-component intervention comprised installation of height-adjustable workstations and organizational-level (management consultation, staff education, manager e-mails to staff) and individual-level (face-to-face coaching, telephone support) elements. Workplace sitting time (minutes/8-hour workday) assessed objectively via activPAL3 devices worn for 7 days at baseline and 3 months (end-of-intervention). At baseline, the mean proportion of workplace sitting time was approximately 77% across all groups (multi-component group 366 minutes/8 hours [SD=49]; workstations-only group 373 minutes/8 hours [SD=36], comparison 365 minutes/8 hours [SD=54]). Following intervention and relative to the comparison group, workplace sitting time in the multi-component group was reduced by 89 minutes/8-hour workday (95% CI=-130, -47 minutes; pworkplace sitting. These findings may have important practical and financial implications for workplaces targeting sitting time reductions. Australian New Zealand Clinical Trials Registry 00363297. © 2013 American Journal of Preventive Medicine Published by American Journal of Preventive Medicine All rights reserved.

A RISC multiprocessor event trigger for the data acquisition system of the H1 experiment at HERA

International Nuclear Information System (INIS)

Campbell, A.J.

1992-01-01

In late 1991 HERA will collide for the first time stored beams of electrons and protons. This paper describes the multiple RISC processor system for online event filtering and reconstruction installed within the data acquisition system of the H1 experiment. Data is processed at a continuous average rate of ∼6 Mbytes/s in parallel by ∼20 R3000 VMEbus based monoboard computers providing some 400 MIPS computing power

Comparison of computer workstation with film for detecting setup errors

International Nuclear Information System (INIS)

Fritsch, D.S.; Boxwala, A.A.; Raghavan, S.; Coffee, C.; Major, S.A.; Muller, K.E.; Chaney, E.L.

1997-01-01

Purpose/Objective: Workstations designed for portal image interpretation by radiation oncologists provide image displays and image processing and analysis tools that differ significantly compared with the standard clinical practice of inspecting portal films on a light box. An implied but unproved assumption associated with the clinical implementation of workstation technology is that patient care is improved, or at least not adversely affected. The purpose of this investigation was to conduct observer studies to test the hypothesis that radiation oncologists can detect setup errors using a workstation at least as accurately as when following standard clinical practice. Materials and Methods: A workstation, PortFolio, was designed for radiation oncologists to display and inspect digital portal images for setup errors. PortFolio includes tools to enhance images; align cross-hairs, field edges, and anatomic structures on reference and acquired images; measure distances and angles; and view registered images superimposed on one another. In a well designed and carefully controlled observer study, nine radiation oncologists, including attendings and residents, used PortFolio to detect setup errors in realistic digitally reconstructed portal (DRPR) images computed from the NLM visible human data using a previously described approach † . Compared with actual portal images where absolute truth is ill defined or unknown, the DRPRs contained known translation or rotation errors in the placement of the fields over target regions in the pelvis and head. Twenty DRPRs with randomly induced errors were computed for each site. The induced errors were constrained to a plane at the isocenter of the target volume and perpendicular to the central axis of the treatment beam. Images used in the study were also printed on film. Observers interpreted the film-based images using standard clinical practice. The images were reviewed in eight sessions. During each session five images were

GEMPAK 5.1 - A GENERAL METEOROLOGICAL PACKAGE (UNIX VERSION)

Science.gov (United States)

Desjardins, M. L.

1994-01-01

GEMPAK is a general meteorological software package developed at NASA/Goddard Space Flight Center. It includes programs to analyze and display surface, upper-air, and gridded data, including model output. There are very general programs to list, edit, and plot data on maps, to display profiles and time series, to draw and fill contours, to draw streamlines, to plot symbols for clouds, sky cover, and pressure tendency, and draw cross sections in the case of gridded data and sounding data. In addition, there are Barnes objective analysis programs to grid surface and upper-air data. The programs include the capabilities to derive meteorological parameters from those found in the dataset, to perform vertical interpolations of sounding data to different coordinate systems, and to compute an extensive set of gridded diagnostic quantities by specifying various nested combinations of scalars and vector arithmetic, algebraic, and differential operators. The GEMPAK 5.1 graphics/transformation subsystem, GEMPLT, provides device-independent graphics. GEMPLT also has the capability to display output in a variety of map projections or overlaid on satellite imagery. GEMPAK 5.1 is written in FORTRAN 77 and C-language and has been implemented on VAX computers under VMS and on computers running the UNIX operating system. During installation and normal use, this package occupies approximately 100Mb of hard disk space. The UNIX version of GEMPAK includes drivers for several graphic output systems including MIT's X Window System (X11,R4), Sun GKS, PostScript (color and monochrome), Silicon Graphics, and others. The VMS version of GEMPAK also includes drivers for several graphic output systems including PostScript (color and monochrome). The VMS version is delivered with the object code for the Transportable Applications Environment (TAE) program, version 4.1 which serves as a user interface. A color monitor is recommended for displaying maps on video display devices. Data for rendering

High-speed parallel implementation of a modified PBR algorithm on DSP-based EH topology

Science.gov (United States)

Rajan, K.; Patnaik, L. M.; Ramakrishna, J.

1997-08-01

Algebraic Reconstruction Technique (ART) is an age-old method used for solving the problem of three-dimensional (3-D) reconstruction from projections in electron microscopy and radiology. In medical applications, direct 3-D reconstruction is at the forefront of investigation. The simultaneous iterative reconstruction technique (SIRT) is an ART-type algorithm with the potential of generating in a few iterations tomographic images of a quality comparable to that of convolution backprojection (CBP) methods. Pixel-based reconstruction (PBR) is similar to SIRT reconstruction, and it has been shown that PBR algorithms give better quality pictures compared to those produced by SIRT algorithms. In this work, we propose a few modifications to the PBR algorithms. The modified algorithms are shown to give better quality pictures compared to PBR algorithms. The PBR algorithm and the modified PBR algorithms are highly compute intensive, Not many attempts have been made to reconstruct objects in the true 3-D sense because of the high computational overhead. In this study, we have developed parallel two-dimensional (2-D) and 3-D reconstruction algorithms based on modified PBR. We attempt to solve the two problems encountered by the PBR and modified PBR algorithms, i.e., the long computational time and the large memory requirements, by parallelizing the algorithm on a multiprocessor system. We investigate the possible task and data partitioning schemes by exploiting the potential parallelism in the PBR algorithm subject to minimizing the memory requirement. We have implemented an extended hypercube (EH) architecture for the high-speed execution of the 3-D reconstruction algorithm using the commercially available fast floating point digital signal processor (DSP) chips as the processing elements (PEs) and dual-port random access memories (DPR) as channels between the PEs. We discuss and compare the performances of the PBR algorithm on an IBM 6000 RISC workstation, on a Silicon

Studies on radio-diagnosis workstations

International Nuclear Information System (INIS)

Niguet, A.

2008-01-01

Radio-diagnosis ranges from mammography to interventional radiology, and represents a great majority of medical examinations, and is therefore the main source of exposure for the population. The author gives an overview of methods for workstation assessment, mainly based on the dose-area product. She indicates the factors affecting the radiation quantity, and evokes the influence of the type of examination. Measurements enable workers to be classified, an adapted dosimetry follow-on to be implemented, working areas to be delimited, collective and individual protections to be implemented, and recommendations to be drafted. Results obtained on a cardiologist are presented

The biomechanical and physiological effect of two dynamic workstations

NARCIS (Netherlands)

Botter, J.; Burford, E.M.; Commissaris, D.; Könemann, R.; Mastrigt, S.H.V.; Ellegast, R.P.

2013-01-01

The aim of this research paper was to investigate the effect, both biomechanically and physiologically, of two dynamic workstations currently available on the commercial market. The dynamic workstations tested, namely the Treadmill Desk by LifeSpan and the LifeBalance Station by RightAngle, were

RISC Processors and High Performance Computing

Science.gov (United States)

Bailey, David H.; Saini, Subhash; Craw, James M. (Technical Monitor)

1995-01-01

This tutorial will discuss the top five RISC microprocessors and the parallel systems in which they are used. It will provide a unique cross-machine comparison not available elsewhere. The effective performance of these processors will be compared by citing standard benchmarks in the context of real applications. The latest NAS Parallel Benchmarks, both absolute performance and performance per dollar, will be listed. The next generation of the NPB will be described. The tutorial will conclude with a discussion of future directions in the field. Technology Transfer Considerations: All of these computer systems are commercially available internationally. Information about these processors is available in the public domain, mostly from the vendors themselves. The NAS Parallel Benchmarks and their results have been previously approved numerous times for public release, beginning back in 1991.

Development and testing of a diagnostic system for intelligen distributed control at EBR-2

International Nuclear Information System (INIS)

Edwards, R.M.; Ruhl, D.W.; Klevans, E.H.; Robinson, G.E.

1990-01-01

A diagnostic system is under development for demonstration of Intelligent Distributed Control at the Experimental Breeder Reactor (EBR--II). In the first phase of the project a diagnostic system is being developed for the EBR-II steam plant based on the DISYS expert systems approach. Current testing uses recorded plant data and data from simulated plant faults. The dynamical simulation of the EBR-II steam plant uses the Babcock and Wilcox (B ampersand W) Modular Modeling System (MMS). At EBR-II the diagnostic system operates in the UNIX workstation and receives live plant data from the plant Data Acquisition System (DAS). Future work will seek implementation of the steam plant diagnostic in a distributed manner using UNIX based computers and Bailey microprocessor-based control system. 10 refs., 6 figs

The microelectronic and photonic test bed RISC processor and DRAM memory stack experiments

International Nuclear Information System (INIS)

Clark, K.A.; Meehan, T.J.

1999-01-01

This paper reports on the on-orbit data obtained from the MPTB RISC Processor Experiment, containing three Integrated Device Technologies R3081 processors. During operations, nine SEUs were observed in the processors, and four SEUs were observed in the memory and/or support circuitry. (authors)

Evaluation of radiological workstations and web-browser-based image distribution clients for a PACS project in hands-on workshops

International Nuclear Information System (INIS)

Boehm, Thomas; Handgraetinger, Oliver; Voellmy, Daniel R.; Marincek, Borut; Wildermuth, Simon; Link, Juergen; Ploner, Ricardo

2004-01-01

The methodology and outcome of a hands-on workshop for the evaluation of PACS (picture archiving and communication system) software for a multihospital PACS project are described. The following radiological workstations and web-browser-based image distribution software clients were evaluated as part of a multistep evaluation of PACS vendors in March 2001: Impax DS 3000 V 4.1/Impax Web1000 (Agfa-Gevaert, Mortsel, Belgium); PathSpeed V 8.0/PathSpeed Web (GE Medical Systems, Milwaukee, Wis., USA); ID Report/ID Web (Image Devices, Idstein, Germany); EasyVision DX/EasyWeb (Philips Medical Systems, Eindhoven, Netherlands); and MagicView 1000 VB33a/MagicWeb (Siemens Medical Systems, Erlangen, Germany). A set of anonymized DICOM test data was provided to enable direct image comparison. Radiologists (n=44) evaluated the radiological workstations and nonradiologists (n=53) evaluated the image distribution software clients using different questionnaires. One vendor was not able to import the provided DICOM data set. Another vendor had problems in displaying imported cross-sectional studies in the correct stack order. Three vendors (Agfa-Gevaert, GE, Philips) presented server-client solutions with web access. Two (Siemens, Image Devices) presented stand-alone solutions. The highest scores in the class of radiological workstations were achieved by ID Report from Image Devices (p<0.005). In the class of image distribution clients, the differences were statistically not significant. Questionnaire-based evaluation was shown to be useful for guaranteeing systematic assessment. The workshop was a great success in raising interest in the PACS project in a large group of future clinical users. The methodology used in the present study may be useful for other hospitals evaluating PACS. (orig.)

Modelling of Energy Expenditure at Welding Workstations: Effect of ...

African Journals Online (AJOL)

The welding workstation usually generates intense heat during operations, which may affect the welder's health if not properly controlled, and can also affect the performance of the welder at work. Consequently, effort to control the conditions of the welding workstation is essential, and is therefore pursued in this paper.

Contribution to data acquisition software of Eurogram and Diamant multi detectors in an Unix/VXWorks environment; Contribution aux logiciels d`acquisition de donnees des multidetecteurs Eurogam et Diamant dans un environnement reparti Unix/VXWorks

Energy Technology Data Exchange (ETDEWEB)

Diarra, C

1994-06-01

Questions on nuclear matter, need to have new performant equipments. Eurogram is a 4 PI gamma radiations multi detector and a precious tool in gamma spectroscopy, but it is necessary to use a charged particles detector and in this aim Diamant is an Eurogram partner. These two multi detectors needed special software data acquisition systems. The whole of acquisition control and management is based on sun stations with unix system. 56 figs., 64 refs.

DATE V1 - Data Aquisition Test Environment Users Manual

CERN Document Server

Grandegger, W; CERN. Geneva

1996-01-01

The Data Aquisition presented here has been developed for maximum portability and generality. If you are lucky you will have tailored the system to your experimental set-up in less than a day and start taking data. It should run any UNIX system and some non-UNIX system and has already been tested on the following systems: Linux (IBM PC and compatible) OSF (Alpha workstations and Medulla VME board) HP-UX (workstation + 743 VME board) HP-RT AIX OS91) LynxOS (tested on a 68040 and a PowerPC) 1) The system was originally developed under UNIX. Only due to popular request of people who wanted to reuse old hardware it was ported to OS9. This is, however, not the recommended hardware and future improvements of the system are not going to be refitted to OS9. Currently we distribute only the OS9 and HP-UX binary versions, but you get the code and can compile it on any of the above systems and with some luck on others.

Client/server models for transparent, distributed computational resources

International Nuclear Information System (INIS)

Hammer, K.E.; Gilman, T.L.

1991-01-01

Client/server models are proposed to address issues of shared resources in a distributed, heterogeneous UNIX environment. Recent development of automated Remote Procedure Call (RPC) interface generator has simplified the development of client/server models. Previously, implementation of the models was only possible at the UNIX socket level. An overview of RPCs and the interface generator will be presented and will include a discussion of generation and installation of remote services, the RPC paradigm, and the three levels of RPC programming. Two applications, the Nuclear Plant Analyzer (NPA) and a fluids simulation using molecular modelling, will be presented to demonstrate how client/server models using RPCs and External Data Representations (XDR) have been used production/computation situations. The NPA incorporates a client/server interface for transferring/translation of TRAC or RELAP results from the UNICOS Cray to a UNIX workstation. The fluids simulation program utilizes the client/server model to access the Cray via a single function allowing it to become a shared co-processor to the workstation application. 5 refs., 6 figs

Workout at work: laboratory test of psychological and performance outcomes of active workstations.

Science.gov (United States)

Sliter, Michael; Yuan, Zhenyu

2015-04-01

With growing concerns over the obesity epidemic in the United States and other developed countries, many organizations have taken steps to incorporate healthy workplace practices. However, most workers are still sedentary throughout the day--a major contributor to individual weight gain. The current study sought to gather preliminary evidence of the efficacy of active workstations, which are a possible intervention that could increase employees' physical activity while they are working. We conducted an experimental study, in which boredom, task satisfaction, stress, arousal, and performance were evaluated and compared across 4 randomly assigned conditions: seated workstation, standing workstation, cycling workstation, and walking workstation. Additionally, body mass index (BMI) and exercise habits were examined as moderators to determine whether differences in these variables would relate to increased benefits in active conditions. The results (n = 180) showed general support for the benefits of walking workstations, whereby participants in the walking condition had higher satisfaction and arousal and experienced less boredom and stress than those in the passive conditions. Cycling workstations, on the other hand, tended to relate to reduced satisfaction and performance when compared with other conditions. The moderators did not impact these relationships, indicating that walking workstations might have psychological benefits to individuals, regardless of BMI and exercise habits. The results of this study are a preliminary step in understanding the work implications of active workstations. (c) 2015 APA, all rights reserved).

Interface and integration of a silicon graphics UNIX computer with the Encore based SCE SONGS 2/3 simulator

International Nuclear Information System (INIS)

Olmos, J.; Lio, P.; Chan, K.S.

1991-01-01

The SONGS Unit 2/3 simulator was originally implemented in 1983 on a Master/Slave 32/7780 Encore MPX platform by the Singer-Link Company. In 1986, a 32/9780 MPX Encore computer was incorporated into the simulator computer system to provide the additional CPU processing needed to install the PACE plant monitoring system and to enable the upgrade of the NSSS Simulation to the advanced RETACT/STK models. Since the spring of 1990, the SCE SONGS Nuclear Training Division simulator technical staff, in cooperation with Micro Simulation Inc., has undertaken a project to integrate a Silicon Graphics UNIX based computer with the Encore MPX SONGS 2/3 simulation computer system. In this paper the authors review the objectives, advantages to be gained, software and hardware approaches utilized, and the results so far achieved by the authors' project

A RISC multiprocessor event trigger for the data acquisition system of the H1 experiment at HERA

International Nuclear Information System (INIS)

Campbell, A.J.

1991-09-01

In late 1991 HERA will for the first time collide stored beams of electrons and protons. This paper describes the multiple (RISC) modern reduced instruction set processor system for online event filtering and reconstruction installed within the data acquisition system of the H1 experiment. Data is processed at a continuous average rate of ∼ 6 Mbytes/s in parallel by ∼ 20 R3000 VMEbus based monoboard computers providing some 400 mips computing power. (author)

CODA: A scalable, distributed data acquisition system

International Nuclear Information System (INIS)

Watson, W.A. III; Chen, J.; Heyes, G.; Jastrzembski, E.; Quarrie, D.

1994-01-01

A new data acquisition system has been designed for physics experiments scheduled to run at CEBAF starting in the summer of 1994. This system runs on Unix workstations connected via ethernet, FDDI, or other network hardware to multiple intelligent front end crates -- VME, CAMAC or FASTBUS. CAMAC crates may either contain intelligent processors, or may be interfaced to VME. The system is modular and scalable, from a single front end crate and one workstation linked by ethernet, to as may as 32 clusters of front end crates ultimately connected via a high speed network to a set of analysis workstations. The system includes an extensible, device independent slow controls package with drivers for CAMAC, VME, and high voltage crates, as well as a link to CEBAF accelerator controls. All distributed processes are managed by standard remote procedure calls propagating change-of-state requests, or reading and writing program variables. Custom components may be easily integrated. The system is portable to any front end processor running the VxWorks real-time kernel, and to most workstations supplying a few standard facilities such as rsh and X-windows, and Motif and socket libraries. Sample implementations exist for 2 Unix workstation families connected via ethernet or FDDI to VME (with interfaces to FASTBUS or CAMAC), and via ethernet to FASTBUS or CAMAC

The Impact of Active Workstations on Workplace Productivity and Performance: A Systematic Review.

Science.gov (United States)

Ojo, Samson O; Bailey, Daniel P; Chater, Angel M; Hewson, David J

2018-02-27

Active workstations have been recommended for reducing sedentary behavior in the workplace. It is important to understand if the use of these workstations has an impact on worker productivity. The aim of this systematic review was to examine the effect of active workstations on workplace productivity and performance. A total of 3303 articles were initially identified by a systematic search and seven articles met eligibility criteria for inclusion. A quality appraisal was conducted to assess risk of bias, confounding, internal and external validity, and reporting. Most of the studies reported cognitive performance as opposed to productivity. Five studies assessed cognitive performance during use of an active workstation, usually in a single session. Sit-stand desks had no detrimental effect on performance, however, some studies with treadmill and cycling workstations identified potential decreases in performance. Many of the studies lacked the power required to achieve statistical significance. Three studies assessed workplace productivity after prolonged use of an active workstation for between 12 and 52 weeks. These studies reported no significant effect on productivity. Active workstations do not appear to decrease workplace performance.

RISC. A new style in the design of architectures

International Nuclear Information System (INIS)

Cortadella, J.; Gonzalez, A.; Llaberia, J.M.

1988-01-01

In the 80's a new architecture design and implementation style has appeared: the RISC style. It proposes an overall view of the system were the processor is included. For each function, an extensive analysis has to be performed in order to evaluate the advantages and disadvantages that hardware and software introduce in the design. An optimum design involved an agreement between both levels and has to take into account cost, performance, and technological factors. In this paper, the main features of this new architecture design style are presented. (Author)

The Datacon Master -- Renovation of a Datacon field bus communications system for accelerator control

International Nuclear Information System (INIS)

Kerner, T.M.

1995-01-01

The Datacon system is a serial coaxial transformer isolated communication field bus system used to control and monitor accelerator remote devices. The Datacon field bus has been a BNL accelerator standard since its initial use in 1965. A single Datacon field bus supports up to 256 devices on a multidrop RG62A/U coaxial cable with up to 33 devices or 2,000 feet between repeaters or buffered branches. The forcing factor to renovate was the inability to repair the aging PDP-8E and PDP10 computers. The maintenance on this aging system was costly and the large number of accelerator devices dependent on the Datacon system could not be converted in a reasonable period of time to a new modern field bus. A commercial VMEbus host CPU mated with a custom designed VMEbus SBC event driven serial communications engine featuring a superscaler RISC 32-bit Intel i960 CPU met the design challenge. The commercial VMEbus host runs the VxWorks real-time operating system and connects to UNIX workstations over a Ethernet LAN. The V110 Datacon Master is the custom designed front end computer that integrates an accelerator event time line system with accelerator devices for up to 8 ppm users adding new capabilities

Workstations take over conceptual design

Science.gov (United States)

Kidwell, George H.

1987-01-01

Workstations provide sufficient computing memory and speed for early evaluations of aircraft design alternatives to identify those worthy of further study. It is recommended that the programming of such machines permit integrated calculations of the configuration and performance analysis of new concepts, along with the capability of changing up to 100 variables at a time and swiftly viewing the results. Computations can be augmented through links to mainframes and supercomputers. Programming, particularly debugging operations, are enhanced by the capability of working with one program line at a time and having available on-screen error indices. Workstation networks permit on-line communication among users and with persons and computers outside the facility. Application of the capabilities is illustrated through a description of NASA-Ames design efforts for an oblique wing for a jet performed on a MicroVAX network.

An Imaging And Graphics Workstation For Image Sequence Analysis

Science.gov (United States)

Mostafavi, Hassan

1990-01-01

This paper describes an application-specific engineering workstation designed and developed to analyze imagery sequences from a variety of sources. The system combines the software and hardware environment of the modern graphic-oriented workstations with the digital image acquisition, processing and display techniques. The objective is to achieve automation and high throughput for many data reduction tasks involving metric studies of image sequences. The applications of such an automated data reduction tool include analysis of the trajectory and attitude of aircraft, missile, stores and other flying objects in various flight regimes including launch and separation as well as regular flight maneuvers. The workstation can also be used in an on-line or off-line mode to study three-dimensional motion of aircraft models in simulated flight conditions such as wind tunnels. The system's key features are: 1) Acquisition and storage of image sequences by digitizing real-time video or frames from a film strip; 2) computer-controlled movie loop playback, slow motion and freeze frame display combined with digital image sharpening, noise reduction, contrast enhancement and interactive image magnification; 3) multiple leading edge tracking in addition to object centroids at up to 60 fields per second from both live input video or a stored image sequence; 4) automatic and manual field-of-view and spatial calibration; 5) image sequence data base generation and management, including the measurement data products; 6) off-line analysis software for trajectory plotting and statistical analysis; 7) model-based estimation and tracking of object attitude angles; and 8) interface to a variety of video players and film transport sub-systems.

Improved operating scenarios of the DIII-D tokamak as a result of the addition of UNIX computer systems

International Nuclear Information System (INIS)

Henline, P.A.

1995-10-01

The increased use of UNIX based computer systems for machine control, data handling and analysis has greatly enhanced the operating scenarios and operating efficiency of the DRI-D tokamak. This paper will describe some of these UNIX systems and their specific uses. These include the plasma control system, the electron cyclotron heating control system, the analysis of electron temperature and density measurements and the general data acquisition system (which is collecting over 130 Mbytes of data). The speed and total capability of these systems has dramatically affected the ability to operate DIII-D. The improved operating scenarios include better plasma shape control due to the more thorough MHD calculations done between shots and the new ability to see the time dependence of profile data as it relates across different spatial locations in the tokamak. Other analysis which engenders improved operating abilities will be described

ARCIMBOLDO_LITE: single-workstation implementation and use.

Science.gov (United States)

Sammito, Massimo; Millán, Claudia; Frieske, Dawid; Rodríguez-Freire, Eloy; Borges, Rafael J; Usón, Isabel

2015-09-01

ARCIMBOLDO solves the phase problem at resolutions of around 2 Å or better through massive combination of small fragments and density modification. For complex structures, this imposes a need for a powerful grid where calculations can be distributed, but for structures with up to 200 amino acids in the asymmetric unit a single workstation may suffice. The use and performance of the single-workstation implementation, ARCIMBOLDO_LITE, on a pool of test structures with 40-120 amino acids and resolutions between 0.54 and 2.2 Å is described. Inbuilt polyalanine helices and iron cofactors are used as search fragments. ARCIMBOLDO_BORGES can also run on a single workstation to solve structures in this test set using precomputed libraries of local folds. The results of this study have been incorporated into an automated, resolution- and hardware-dependent parameterization. ARCIMBOLDO has been thoroughly rewritten and three binaries are now available: ARCIMBOLDO_LITE, ARCIMBOLDO_SHREDDER and ARCIMBOLDO_BORGES. The programs and libraries can be downloaded from http://chango.ibmb.csic.es/ARCIMBOLDO_LITE.

Flexible structure control experiments using a real-time workstation for computer-aided control engineering

Science.gov (United States)

Stieber, Michael E.

1989-01-01

A Real-Time Workstation for Computer-Aided Control Engineering has been developed jointly by the Communications Research Centre (CRC) and Ruhr-Universitaet Bochum (RUB), West Germany. The system is presently used for the development and experimental verification of control techniques for large space systems with significant structural flexibility. The Real-Time Workstation essentially is an implementation of RUB's extensive Computer-Aided Control Engineering package KEDDC on an INTEL micro-computer running under the RMS real-time operating system. The portable system supports system identification, analysis, control design and simulation, as well as the immediate implementation and test of control systems. The Real-Time Workstation is currently being used by CRC to study control/structure interaction on a ground-based structure called DAISY, whose design was inspired by a reflector antenna. DAISY emulates the dynamics of a large flexible spacecraft with the following characteristics: rigid body modes, many clustered vibration modes with low frequencies and extremely low damping. The Real-Time Workstation was found to be a very powerful tool for experimental studies, supporting control design and simulation, and conducting and evaluating tests withn one integrated environment.

STAR- A SIMPLE TOOL FOR AUTOMATED REASONING SUPPORTING HYBRID APPLICATIONS OF ARTIFICIAL INTELLIGENCE (UNIX VERSION)

Science.gov (United States)

Borchardt, G. C.

1994-01-01

/output required, and displays the results. The STAR interpreter is written in the C language for interactive execution. It has been implemented on a VAX 11/780 computer operating under VMS, and the UNIX version has been implemented on a Sun Microsystems 2/170 workstation. STAR has a memory requirement of approximately 200K of 8 bit bytes, excluding externally compiled functions and application-dependent symbolic definitions. This program was developed in 1985.

Out-of-core nuclear fuel cycle optimization utilizing an engineering workstation

International Nuclear Information System (INIS)

Turinsky, P.J.; Comes, S.A.

1986-01-01

Within the past several years, rapid advances in computer technology have resulted in substantial increases in their performance. The net effect is that problems that could previously only be executed on mainframe computers can now be executed on micro- and minicomputers. The authors are interested in developing an engineering workstation for nuclear fuel management applications. An engineering workstation is defined as a microcomputer with enhanced graphics and communication capabilities. Current fuel management applications range from using workstations as front-end/back-end processors for mainframe computers to completing fuel management scoping calculations. More recently, interest in using workstations for final in-core design calculations has appeared. The authors have used the VAX 11/750 minicomputer, which is not truly an engineering workstation but has comparable performance, to complete both in-core and out-of-core fuel management scoping studies. In this paper, the authors concentrate on our out-of-core research. While much previous work in this area has dealt with decisions concerned with equilibrium cycles, the current project addresses the more realistic situation of nonequilibrium cycles

The Impact of Active Workstations on Workplace Productivity and Performance: A Systematic Review

Directory of Open Access Journals (Sweden)

Samson O. Ojo

2018-02-01

Full Text Available Active workstations have been recommended for reducing sedentary behavior in the workplace. It is important to understand if the use of these workstations has an impact on worker productivity. The aim of this systematic review was to examine the effect of active workstations on workplace productivity and performance. A total of 3303 articles were initially identified by a systematic search and seven articles met eligibility criteria for inclusion. A quality appraisal was conducted to assess risk of bias, confounding, internal and external validity, and reporting. Most of the studies reported cognitive performance as opposed to productivity. Five studies assessed cognitive performance during use of an active workstation, usually in a single session. Sit-stand desks had no detrimental effect on performance, however, some studies with treadmill and cycling workstations identified potential decreases in performance. Many of the studies lacked the power required to achieve statistical significance. Three studies assessed workplace productivity after prolonged use of an active workstation for between 12 and 52 weeks. These studies reported no significant effect on productivity. Active workstations do not appear to decrease workplace performance.

Functionalized 2PP structures for the BioPhotonics Workstation

DEFF Research Database (Denmark)

Matsuoka, Tomoyo; Nishi, Masayuki; Sakakura, Masaaki

2011-01-01

In its standard version, our BioPhotonics Workstation (BWS) can generate multiple controllable counter-propagating beams to create real-time user-programmable optical traps for stable three-dimensional control and manipulation of a plurality of particles. The combination of the platform with micr...... on the BWS platform by functionalizing them with silica-based sol-gel materials inside which dyes can be entrapped....

Initial experience with a nuclear medicine viewing workstation

Science.gov (United States)

Witt, Robert M.; Burt, Robert W.

1992-07-01

Graphical User Interfaced (GUI) workstations are now available from commercial vendors. We recently installed a GUI workstation in our nuclear medicine reading room for exclusive use of staff and resident physicians. The system is built upon a Macintosh platform and has been available as a DELTAmanager from MedImage and more recently as an ICON V from Siemens Medical Systems. The workstation provides only display functions and connects to our existing nuclear medicine imaging system via ethernet. The system has some processing capabilities to create oblique, sagittal and coronal views from transverse tomographic views. Hard copy output is via a screen save device and a thermal color printer. The DELTAmanager replaced a MicroDELTA workstation which had both process and view functions. The mouse activated GUI has made remarkable changes to physicians'' use of the nuclear medicine viewing system. Training time to view and review studies has been reduced from hours to about 30-minutes. Generation of oblique views and display of brain and heart tomographic studies has been reduced from about 30-minutes of technician''s time to about 5-minutes of physician''s time. Overall operator functionality has been increased so that resident physicians with little prior computer experience can access all images on the image server and display pertinent patient images when consulting with other staff.

PC as physics computer for LHC?

CERN Document Server

Jarp, S; Simmins, A; Yaari, R; Jarp, Sverre; Tang, Hong; Simmins, Antony; Yaari, Refael

1995-01-01

In the last five years, we have seen RISC workstations take over the computing scene that was once controlled by mainframes and supercomputers. In this paper we will argue that the same phenomenon might happen again. A project, active since March this year in the Physics Data Processing group of CERN's CN division is described where ordinary desktop PCs running Windows (NT and 3.11) have been used for creating an environment for running large LHC batch jobs (initially the DICE simulation job of Atlas). The problems encountered in porting both the CERN library and the specific Atlas codes are described together with some encouraging benchmark results when comparing to existing RISC workstations in use by the Atlas collaboration. The issues of establishing the batch environment (Batch monitor, staging software, etc.) are also covered. Finally a quick extrapolation of commodity computing power available in the future is touched upon to indicate what kind of cost envelope could be sufficient for the simulation fa...

Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases.

Science.gov (United States)

Hernández, Armando R; Peterson, Larryn W; Kool, Eric T

2012-08-17

Understanding the interactions between small interfering RNAs (siRNAs) and the RNA-induced silencing complex (RISC), the key protein complex of RNA interference (RNAi), is of great importance to the development of siRNAs with improved biological and potentially therapeutic function. Although various chemically modified siRNAs have been reported, relatively few studies with modified nucleobases exist. Here we describe the synthesis and hybridization properties of siRNAs bearing size-expanded RNA (xRNA) nucleobases and their use as a novel and systematic set of steric probes in RNAi. xRNA nucleobases are expanded by 2.4 Å using benzo-homologation and retain canonical Watson-Crick base-pairing groups. Our data show that the modified siRNA duplexes display small changes in melting temperature (+1.4 to -5.0 °C); substitutions near the center are somewhat destabilizing to the RNA duplex, while substitutions near the ends are stabilizing. RNAi studies in a dual-reporter luciferase assay in HeLa cells revealed that xRNA nucleobases in the antisense strand reduce activity at some central positions near the seed region but are generally well tolerated near the ends. Most importantly, we observed that xRNA substitutions near the 3'-end increased activity over that of wild-type siRNAs. The data are analyzed in terms of site-dependent steric effects in RISC. Circular dichroism experiments show that single xRNA substitutions do not significantly distort the native A-form helical structure of the siRNA duplex, and serum stability studies demonstrated that xRNA substitutions protect siRNAs against nuclease degradation.

An approach to develop a PSA workstation in KAERI

International Nuclear Information System (INIS)

Kim, T. W.; Han, S. H.; Park, C. K.

1995-01-01

This paper describes three kinds of efforts for the development of PSA workstation in KAERI; Development of a PSA tool, KIRAP, Reliability Database Development, Living PSA tool development. Korea has 9 nuclear power plants (NPPs) in operation and 9 NPPs under design or construction. For the NPPs recently constructed or designed, the probabilistic safety assessments (PSAs) have been performed by the Government requirements. For these PSAs, the MSDOS version of KIRAP has been used. For the consistent data management and the easiness of information handling needed in PSA, APSA workstation, KIRAP-Win is under development under Windows environment. For the reliability database on component failure rate, human error rate, and common cause failure rate, data used in international PSA or reliability data handbook are collected and processed to use in Korean new plants' PSAs. Finally, an effort for the development of a living PSA tool in KAERI based on dynamic PSA concept is described

Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling.

Science.gov (United States)

Kourtidis, Antonis; Necela, Brian; Lin, Wan-Hsin; Lu, Ruifeng; Feathers, Ryan W; Asmann, Yan W; Thompson, E Aubrey; Anastasiadis, Panos Z

2017-10-02

Cumulative evidence demonstrates that most RNAs exhibit specific subcellular distribution. However, the mechanisms regulating this phenomenon and its functional consequences are still under investigation. Here, we reveal that cadherin complexes at the apical zonula adherens (ZA) of epithelial adherens junctions recruit the core components of the RNA-induced silencing complex (RISC) Ago2, GW182, and PABPC1, as well as a set of 522 messenger RNAs (mRNAs) and 28 mature microRNAs (miRNAs or miRs), via PLEKHA7. Top canonical pathways represented by these mRNAs include Wnt/β-catenin, TGF-β, and stem cell signaling. We specifically demonstrate the presence and silencing of MYC, JUN, and SOX2 mRNAs by miR-24 and miR-200c at the ZA. PLEKHA7 knockdown dissociates RISC from the ZA, decreases loading of the ZA-associated mRNAs and miRNAs to Ago2, and results in a corresponding increase of MYC, JUN, and SOX2 protein expression. The present work reveals a mechanism that directly links junction integrity to the silencing of a set of mRNAs that critically affect epithelial homeostasis. © 2017 Kourtidis et al.

Depletion of key protein components of the RISC pathway impairs pre-ribosomal RNA processing.

Science.gov (United States)

Liang, Xue-Hai; Crooke, Stanley T

2011-06-01

Little is known about whether components of the RNA-induced silencing complex (RISC) mediate the biogenesis of RNAs other than miRNA. Here, we show that depletion of key proteins of the RISC pathway by antisense oligonucleotides significantly impairs pre-rRNA processing in human cells. In cells depleted of Drosha or Dicer, different precursors to 5.8S rRNA strongly accumulated, without affecting normal endonucleolytic cleavages. Moderate yet distinct processing defects were also observed in Ago2-depleted cells. Physical links between pre-rRNA and these proteins were identified by co-immunoprecipitation analyses. Interestingly, simultaneous depletion of Dicer and Drosha led to a different processing defect, causing slower production of 28S rRNA and its precursor. Both Dicer and Ago2 were detected in the nuclear fraction, and reduction of Dicer altered the structure of the nucleolus, where pre-rRNA processing occurs. Together, these results suggest that Drosha and Dicer are implicated in rRNA biogenesis.

Making the PACS workstation a browser of image processing software: a feasibility study using inter-process communication techniques.

Science.gov (United States)

Wang, Chunliang; Ritter, Felix; Smedby, Orjan

2010-07-01

To enhance the functional expandability of a picture archiving and communication systems (PACS) workstation and to facilitate the integration of third-part image-processing modules, we propose a browser-server style method. In the proposed solution, the PACS workstation shows the front-end user interface defined in an XML file while the image processing software is running in the background as a server. Inter-process communication (IPC) techniques allow an efficient exchange of image data, parameters, and user input between the PACS workstation and stand-alone image-processing software. Using a predefined communication protocol, the PACS workstation developer or image processing software developer does not need detailed information about the other system, but will still be able to achieve seamless integration between the two systems and the IPC procedure is totally transparent to the final user. A browser-server style solution was built between OsiriX (PACS workstation software) and MeVisLab (Image-Processing Software). Ten example image-processing modules were easily added to OsiriX by converting existing MeVisLab image processing networks. Image data transfer using shared memory added communication based on IPC techniques is an appealing method that allows PACS workstation developers and image processing software developers to cooperate while focusing on different interests.

Contribution to data acquisition software of Eurogram and Diamant multi detectors in an Unix/VXWorks environment

International Nuclear Information System (INIS)

Diarra, C.

1994-06-01

Questions on nuclear matter, need to have new performant equipments. Eurogram is a 4 PI gamma radiations multi detector and a precious tool in gamma spectroscopy, but it is necessary to use a charged particles detector and in this aim Diamant is an Eurogram partner. These two multi detectors needed special software data acquisition systems. The whole of acquisition control and management is based on sun stations with unix system. 56 figs., 64 refs

ERGONOMICs IN THE COMPUTER WORKsTATION

African Journals Online (AJOL)

2010-09-09

Sep 9, 2010 ... in relation to their work environment and working surroundings. ... prolonged computer usage and application of ergonomics in the workstation. Design:One hundred and .... Occupational Health and Safety Services should.

Feasibility study of BES data processing and physics analysis on a PC/Linux platform

International Nuclear Information System (INIS)

Rong Gang; He Kanglin; Zhao Jiawei; Heng Yuekun; Zhang Chun

1999-01-01

The authors report a feasibility study of off-line BES data processing (data reconstruction and Detector simulation) on a PC/Linux platform and an application of the PC/Linux system in D/Ds physics analysis. The authors compared the results obtained from the PC/Linux with that from HP workstation. It shows that PC/Linux platform can do BES data offline analysis as good as UNIX workstation do, but it is much powerful and economical

Control of a pulse height analyzer using an RDX workstation

International Nuclear Information System (INIS)

Montelongo, S.; Hunt, D.N.

1984-12-01

The Nuclear Chemistry Division of Lawrence Livermore National laboratory is in the midst of upgrading its radiation counting facilities to automate data acquisition and quality control. This upgrade requires control of a pulse height analyzer (PHA) from an interactive LSI-11/23 workstation running RSX-11M. The PHA is a micro-computer based multichannel analyzer system providing data acquisition, storage, display, manipulation and input/output from up to four independent acquisition interfaces. Control of the analyzer includes reading and writing energy spectra, issuing commands, and servicing device interrupts. The analyzer communicates to the host system over a 9600-baud serial line using the Digital Data Communications link level Protocol (DDCMP). We relieved the RSX workstation CPU from the DDCMP overhead by implementing a DEC compatible in-house designed DMA serial line board (the ISL-11) to communicate with the analyzer. An RSX I/O device driver was written to complete the path between the analyzer and the RSX system by providing the link between the communication board and an application task. The I/O driver is written to handle several ISL-11 cards all operating in parallel thus providing support for control of multiple analyzers from a single workstation. The RSX device driver, its design and use by application code controlling the analyzer, and its operating environment will be discussed

Development of an intelligent CAI system for a distributed processing environment

International Nuclear Information System (INIS)

Fujii, M.; Sasaki, K.; Ohi, T.; Itoh, T.

1993-01-01

In order to operate a nuclear power plant optimally in both normal and abnormal situations, the operators are trained using an operator training simulator in addition to classroom instruction. Individual instruction using a CAI (Computer-Assisted Instruction) system has become popular as a method of learning plant information, such as plant dynamics, operational procedures, plant systems, plant facilities, etc. The outline is described of a proposed network-based intelligent CAI system (ICAI) incorporating multi-medial PWR plant dynamics simulation, teaching aids and educational record management using the following environment: existing standard workstations and graphic workstations with a live video processing function, TCP/IP protocol of Unix through Ethernet and X window system. (Z.S.) 3 figs., 2 refs

MCNP load balancing and fault tolerance with PVM

International Nuclear Information System (INIS)

McKinney, G.W.

1995-01-01

Version 4A of the Monte Carlo neutron, photon, and electron transport code MCNP, developed by LANL (Los Alamos National Laboratory), supports distributed-memory multiprocessing through the software package PVM (Parallel Virtual Machine, version 3.1.4). Using PVM for interprocessor communication, MCNP can simultaneously execute a single problem on a cluster of UNIX-based workstations. This capability provided system efficiencies that exceeded 80% on dedicated workstation clusters, however, on heterogeneous or multiuser systems, the performance was limited by the slowest processor (i.e., equal work was assigned to each processor). The next public release of MCNP will provide multiprocessing enhancements that include load balancing and fault tolerance which are shown to dramatically increase multiuser system efficiency and reliability

PAW [Physics Analysis Workstation] at Fermilab: CORE based graphics implementation of HIGZ [High Level Interface to Graphics and Zebra

International Nuclear Information System (INIS)

Johnstad, H.

1989-06-01

The Physics Analysis Workstation system (PAW) is primarily intended to be the last link in the analysis chain of experimental data. The graphical part of PAW is based on HIGZ (High Level Interface to Graphics and Zebra), which is based on the OSI and ANSI standard Graphics Kernel System (GKS). HIGZ is written in the context of PAW. At Fermilab, the CORE based graphics system DI-3000 by Precision Visuals Inc., is widely used in the analysis of experimental data. The graphical part of the PAW routines has been totally rewritten and implemented in the Fermilab environment. 3 refs

Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study

DEFF Research Database (Denmark)

Bot, M; Pouwer, F; De Jonge, P

2013-01-01

Sensitivity and Cardiovascular Disease Risk (RISC) study. Presence of significant depressive symptoms was defined as a Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 16. Standard oral glucose tolerance tests were performed. Insulin sensitivity was assessed with the oral glucose insulin......AIM: This study explored the association of depressive symptoms with indices of insulin sensitivity and insulin secretion in a cohort of non-diabetic men and women aged 30 to 64 years. METHODS: The study population was derived from the 3-year follow-up of the Relationship between Insulin...... sensitivity (OGIS) index. Insulin secretion was estimated using three model-based parameters of insulin secretion (beta-cell glucose sensitivity, the potentiation factor ratio, and beta-cell rate sensitivity). RESULTS: A total of 162 out of 1027 participants (16%) had significant depressive symptoms. Having...

GOLD: Integration of model-based control systems with artificial intelligence and workstations

International Nuclear Information System (INIS)

Lee, M.; Clearwater, S.

1987-08-01

Our experience with model-based accelerator control started at SPEAR. Since that time nearly all accelerator beamlines have been controlled using model-based application programs, for example, PEP and SLC at SLAC. In order to take advantage of state-of-the-art hardware and software technology, the design and implementation of the accelerator control programs have undergone radical changes with time. Consequently, SPEAR, PEP and SLC all use different control programs. Since many of these application programs are embedded deep into the control system, they had to be rewritten each time. Each time this rewriting has occurred a great deal of time and effort has been spent on training physicists and programmers to do the job. Now, we have developed an integrated system called GOLD (Genetic Orbit and Lattice Debugger) for debugging and correcting trajectory errors in accelerator lattices. The system consists of a lattice modeling program (COMFORT), a beam simulator (PLUS), a graphical workstation environment (micro-VAX) and an expert system (ABLE). This paper will describe some of the features and applications of our integrated system with emphasis on the automation offered by expert systems. 5 refs

A workstation-integrated peer review quality assurance program: pilot study

International Nuclear Information System (INIS)

O’Keeffe, Margaret M; Davis, Todd M; Siminoski, Kerry

2013-01-01

The surrogate indicator of radiological excellence that has become accepted is consistency of assessments between radiologists, and the technique that has become the standard for evaluating concordance is peer review. This study describes the results of a workstation-integrated peer review program in a busy outpatient radiology practice. Workstation-based peer review was performed using the software program Intelerad Peer Review. Cases for review were randomly chosen from those being actively reported. If an appropriate prior study was available, and if the reviewing radiologist and the original interpreting radiologist had not exceeded review targets, the case was scored using the modified RADPEER system. There were 2,241 cases randomly assigned for peer review. Of selected cases, 1,705 (76%) were interpreted. Reviewing radiologists agreed with prior reports in 99.1% of assessments. Positive feedback (score 0) was given in three cases (0.2%) and concordance (scores of 0 to 2) was assigned in 99.4%, similar to reported rates of 97.0% to 99.8%. Clinically significant discrepancies (scores of 3 or 4) were identified in 10 cases (0.6%). Eighty-eight percent of reviewed radiologists found the reviews worthwhile, 79% found scores appropriate, and 65% felt feedback was appropriate. Two-thirds of radiologists found case rounds discussing significant discrepancies to be valuable. The workstation-based computerized peer review process used in this pilot project was seamlessly incorporated into the normal workday and met most criteria for an ideal peer review system. Clinically significant discrepancies were identified in 0.6% of cases, similar to published outcomes using the RADPEER system. Reviewed radiologists felt the process was worthwhile

A workstation-integrated peer review quality assurance program: pilot study

Science.gov (United States)

2013-01-01

Background The surrogate indicator of radiological excellence that has become accepted is consistency of assessments between radiologists, and the technique that has become the standard for evaluating concordance is peer review. This study describes the results of a workstation-integrated peer review program in a busy outpatient radiology practice. Methods Workstation-based peer review was performed using the software program Intelerad Peer Review. Cases for review were randomly chosen from those being actively reported. If an appropriate prior study was available, and if the reviewing radiologist and the original interpreting radiologist had not exceeded review targets, the case was scored using the modified RADPEER system. Results There were 2,241 cases randomly assigned for peer review. Of selected cases, 1,705 (76%) were interpreted. Reviewing radiologists agreed with prior reports in 99.1% of assessments. Positive feedback (score 0) was given in three cases (0.2%) and concordance (scores of 0 to 2) was assigned in 99.4%, similar to reported rates of 97.0% to 99.8%. Clinically significant discrepancies (scores of 3 or 4) were identified in 10 cases (0.6%). Eighty-eight percent of reviewed radiologists found the reviews worthwhile, 79% found scores appropriate, and 65% felt feedback was appropriate. Two-thirds of radiologists found case rounds discussing significant discrepancies to be valuable. Conclusions The workstation-based computerized peer review process used in this pilot project was seamlessly incorporated into the normal workday and met most criteria for an ideal peer review system. Clinically significant discrepancies were identified in 0.6% of cases, similar to published outcomes using the RADPEER system. Reviewed radiologists felt the process was worthwhile. PMID:23822583

DET/MPS - THE GSFC ENERGY BALANCE PROGRAM, DIRECT ENERGY TRANSFER/MULTIMISSION SPACECRAFT MODULAR POWER SYSTEM (UNIX VERSION)

Science.gov (United States)

Jagielski, J. M.

1994-01-01

The DET/MPS programs model and simulate the Direct Energy Transfer and Multimission Spacecraft Modular Power System in order to aid both in design and in analysis of orbital energy balance. Typically, the DET power system has the solar array directly to the spacecraft bus, and the central building block of MPS is the Standard Power Regulator Unit. DET/MPS allows a minute-by-minute simulation of the power system's performance as it responds to various orbital parameters, focusing its output on solar array output and battery characteristics. While this package is limited in terms of orbital mechanics, it is sufficient to calculate eclipse and solar array data for circular or non-circular orbits. DET/MPS can be adjusted to run one or sequential orbits up to about one week, simulated time. These programs have been used on a variety of Goddard Space Flight Center spacecraft projects. DET/MPS is written in FORTRAN 77 with some VAX-type extensions. Any FORTRAN 77 compiler that includes VAX extensions should be able to compile and run the program with little or no modifications. The compiler must at least support free-form (or tab-delineated) source format and 'do do-while end-do' control structures. DET/MPS is available for three platforms: GSC-13374, for DEC VAX series computers running VMS, is available in DEC VAX Backup format on a 9-track 1600 BPI tape (standard distribution) or TK50 tape cartridge; GSC-13443, for UNIX-based computers, is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format; and GSC-13444, for Macintosh computers running AU/X with either the NKR FORTRAN or AbSoft MacFORTRAN II compilers, is available on a 3.5 inch 800K Macintosh format diskette. Source code and test data are supplied. The UNIX version of DET requires 90K of main memory for execution. DET/MPS was developed in 1990. A/UX and Macintosh are registered trademarks of Apple Computer, Inc. VMS, DEC VAX and TK50 are trademarks of Digital Equipment Corporation. UNIX is a

Evaluation of training nurses to perform semi-automated three-dimensional left ventricular ejection fraction using a customised workstation-based training protocol.

Science.gov (United States)

Guppy-Coles, Kristyan B; Prasad, Sandhir B; Smith, Kym C; Hillier, Samuel; Lo, Ada; Atherton, John J

2015-06-01

We aimed to determine the feasibility of training cardiac nurses to evaluate left ventricular function utilising a semi-automated, workstation-based protocol on three dimensional echocardiography images. Assessment of left ventricular function by nurses is an attractive concept. Recent developments in three dimensional echocardiography coupled with border detection assistance have reduced inter- and intra-observer variability and analysis time. This could allow abbreviated training of nurses to assess cardiac function. A comparative, diagnostic accuracy study evaluating left ventricular ejection fraction assessment utilising a semi-automated, workstation-based protocol performed by echocardiography-naïve nurses on previously acquired three dimensional echocardiography images. Nine cardiac nurses underwent two brief lectures about cardiac anatomy, physiology and three dimensional left ventricular ejection fraction assessment, before a hands-on demonstration in 20 cases. We then selected 50 cases from our three dimensional echocardiography library based on optimal image quality with a broad range of left ventricular ejection fractions, which was quantified by two experienced sonographers and the average used as the comparator for the nurses. Nurses independently measured three dimensional left ventricular ejection fraction using the Auto lvq package with semi-automated border detection. The left ventricular ejection fraction range was 25-72% (70% with a left ventricular ejection fraction nurses showed excellent agreement with the sonographers. Minimal intra-observer variability was noted on both short-term (same day) and long-term (>2 weeks later) retest. It is feasible to train nurses to measure left ventricular ejection fraction utilising a semi-automated, workstation-based protocol on previously acquired three dimensional echocardiography images. Further study is needed to determine the feasibility of training nurses to acquire three dimensional echocardiography

FORTRAN data files transference from VAX/VMS to ALPHA/UNIX; Traspaso de ficheros FORTRAN de datos de VAX/VMS a ALPHA/UNIX

Energy Technology Data Exchange (ETDEWEB)

Sanchez, E.; Milligen, B. Ph van [CIEMAT (Spain)

1997-09-01

Several tools have been developed to access the TJ-IU databases, which currently reside in VAX/VMS servers, from the TJ-II Data Acquisition System DEC ALPHA 8400 server. The TJ-I/TJ-IU databases are not homogeneous and contain several types of data files, namely, SADE, CAMAC and FORTRAN unformatted files. The tools presented in this report allow one to transfer CAMAC and those FORTRAN unformatted files defined herein, from a VAX/VMS server, for data manipulation on the ALPHA/Digital UNIX server. (Author)

Control system for the Spanish Stellarator TJ-II

International Nuclear Information System (INIS)

Pacios, L.; Blaumoser, M.; Pena, A. de la; Carrasco, R.; Labrador, I.; Lapayese, F.; Diaz, J.C.; Laso, L.M.

1995-01-01

We describe the distributed control and monitoring system for the Spanish Stellarator TJ-II, which is under construction at CIEMAT in Madrid. It consists of one central UNIX workstation and several autonomous subsystems based on VME crates with embedded processors under OS-9 real-time operating system and PLCs. The system integrates the machine and discharge control. An operator can perform the control and plasma discharge by means of a user-friendly graphic interface. (orig.)

Access to CAMAC from VxWorks and UNIX in DART

International Nuclear Information System (INIS)

Streets, J.; Meadows, J.; Moore, C.

1995-05-01

As part of the DART Project the authors have developed a package of software for CAMAC access from UNIX and VxWorks platforms, with support for several hardware interfaces. They report on developments for the CES CBD8210 VME to parallel CAMAC, the Hytec VSD2992 VME to serial CAMAC and Jorway 411S SCSI to parallel and serial CAMAC branch drivers, and give a summary of the timings obtained

Low cost RISC implementation of intelligent ultra fast charger for Ni-Cd battery

International Nuclear Information System (INIS)

Petchjatuporn, Panom; Sirisuk, Phaophak; Khaehintung, Noppadol; Sunat, Khamron; Wicheanchote, Phinyo; Kiranon, Wiwat

2008-01-01

This paper presents a low cost reduced instruction set computer (RISC) implementation of an intelligent ultra fast charger for a nickel-cadmium (Ni-Cd) battery. The charger employs a genetic algorithm (GA) trained generalized regression neural network (GRNN) as a key to ultra fast charging while avoiding battery damage. The tradeoff between mean square error (MSE) and the computational burden of the GRNN is addressed. Besides, an efficient technique is proposed for estimation of a radial basis function (RBF) in the GRNN. Hardware realization based upon the techniques is discussed. Experimental results with commercial Ni-Cd batteries reveal that while the proposed charger significantly reduces the charging time, it scarcely deteriorates the battery energy storage capability when compared with the conventional charger

Low cost RISC implementation of intelligent ultra fast charger for Ni-Cd battery

Energy Technology Data Exchange (ETDEWEB)

Petchjatuporn, Panom; Khaehintung, Noppadol [Department of Control and Instrumentation Engineering, Faculty of Engineering, Mahanakorn University of Technology, Bangkok 10530 (Thailand); Sirisuk, Phaophak; Sunat, Khamron [Department of Computer Engineering, Faculty of Engineering, Mahanakorn University of Technology, Bangkok 10530 (Thailand); Wicheanchote, Phinyo [Test Engineering Department, Sanmina-SCI Systems Co. Ltd. (Thailand); Kiranon, Wiwat [Department of Telecommunication Engineering, Faculty of Engineering, King Mongkut' s Institue of Technology, Ladkrabang, Bangkok 10520 (Thailand)

2008-02-15

This paper presents a low cost reduced instruction set computer (RISC) implementation of an intelligent ultra fast charger for a nickel-cadmium (Ni-Cd) battery. The charger employs a genetic algorithm (GA) trained generalized regression neural network (GRNN) as a key to ultra fast charging while avoiding battery damage. The tradeoff between mean square error (MSE) and the computational burden of the GRNN is addressed. Besides, an efficient technique is proposed for estimation of a radial basis function (RBF) in the GRNN. Hardware realization based upon the techniques is discussed. Experimental results with commercial Ni-Cd batteries reveal that while the proposed charger significantly reduces the charging time, it scarcely deteriorates the battery energy storage capability when compared with the conventional charger. (author)

Real-time monitoring/emergency response modeling workstation for a tritium facility

International Nuclear Information System (INIS)

Lawver, B.S.; Sims, J.M.; Baskett, R.L.

1993-01-01

At Lawrence Livermore National Laboratory (LLNL) we have developed a real-time system to monitor two stacks on our tritium handling facility. The monitors transmit the stack data to a workstation, which computes a three-dimensional numerical model of atmospheric dispersion. The workstation also collects surface and upper air data from meteorological towers and a sodar. The complex meteorological and terrain setting in the Livermore Valley demands more sophisticated resolution of the three-dimensional structure of the atmosphere to reliably calculate plume dispersion than afforded by Gaussian models. We experience both mountain valley and sea breeze flows. To address these complexities, we have implemented the three-dimensional diagnostic MATHEW mass-adjusted wind field and ADPIC particle-in-cell dispersion models on the workstation for use in real-time emergency response modeling. Both MATHEW and ADPIC have shown their utility in a variety of complex settings over the last 15 yr within the U.S. Department of Energy's Atmospheric Release Advisory Capability (ARAC) project. Faster workstations and real-time instruments allow utilization of more complex three-dimensional models, which provides a foundation for building a real-time monitoring and emergency response workstation for a tritium facility. The stack monitors are two ion chambers per stack

SunFast: A sun workstation based, fuel analysis scoping tool for pressurized water reactors

International Nuclear Information System (INIS)

Bohnhoff, W.J.

1991-05-01

The objective of this research was to develop a fuel cycle scoping program for light water reactors and implement the program on a workstation class computer. Nuclear fuel management problems are quite formidable due to the many fuel arrangement options available. Therefore, an engineer must perform multigroup diffusion calculations for a variety of different strategies in order to determine an optimum core reload. Standard fine mesh finite difference codes result in a considerable computational cost. A better approach is to build upon the proven reliability of currently available mainframe computer programs, and improve the engineering efficiency by taking advantage of the most useful characteristic of workstations: enhanced man/machine interaction. This dissertation contains a description of the methods and a user's guide for the interactive fuel cycle scoping program, SunFast. SunFast provides computational speed and accuracy of solution along with a synergetic coupling between the user and the machine. It should prove to be a valuable tool when extensive sets of similar calculations must be done at a low cost as is the case for assessing fuel management strategies. 40 refs

Optimizing the pathology workstation "cockpit": Challenges and solutions

Directory of Open Access Journals (Sweden)

Elizabeth A Krupinski

2010-01-01

Full Text Available The 21 st century has brought numerous changes to the clinical reading (i.e., image or virtual pathology slide interpretation environment of pathologists and it will continue to change even more dramatically as information and communication technologies (ICTs become more widespread in the integrated healthcare enterprise. The extent to which these changes impact the practicing pathologist differ as a function of the technology under consideration, but digital "virtual slides" and the viewing of images on computer monitors instead of glass slides through a microscope clearly represents a significant change in the way that pathologists extract information from these images and render diagnostic decisions. One of the major challenges facing pathologists in this new era is how to best optimize the pathology workstation, the reading environment and the new and varied types of information available in order to ensure efficient and accurate processing of this information. Although workstations can be stand-alone units with images imported via external storage devices, this scenario is becoming less common as pathology departments connect to information highways within their hospitals and to external sites. Picture Archiving and Communications systems are no longer confined to radiology departments but are serving the entire integrated healthcare enterprise, including pathology. In radiology, the workstation is often referred to as the "cockpit" with a "digital dashboard" and the reading room as the "control room." Although pathology has yet to "go digital" to the extent that radiology has, lessons derived from radiology reading "cockpits" can be quite valuable in setting up the digital pathology reading room. In this article, we describe the concept of the digital dashboard and provide some recent examples of informatics-based applications that have been shown to improve the workflow and quality in digital reading environments.

Status of JT-60 data processing system

International Nuclear Information System (INIS)

Matsuda, T.; Tsugita, T.; Oshima, T.; Sakata, S.; Sato, M.; Koiwa, M.; Aoyagi, T.

2000-01-01

The JT-60 data processing system is a large computer complex and gradually modernized by utilizing progressing computer and network technology. There are two major changes in our system. A main computer of FACOM M-780 has been replaced with compatible GS8300 using state-of-art CMOS technology, which results in lower power and space usage with nearly the same performance. Now it can handle ∼500 MB of data per discharge. A gigabit ethernet switch with FDDI ports has been introduced to cope with the increase of handling data. The switch will connect a tera-byte (TB) data server at the bandwidth of a gigabit per second with the main computer and many data acquisition workstations. Other developments in our system are the realization of three workstation-based plans, the TB data server, the VME-based fast data acquisition system and a CICU. The TB data server is basically a UNIX workstation with ∼100 GB RAID disks and ∼900 GB MO auto-exchangers. The VME-based fast data acquisition system has been developed to enlarge the present TMDS. The CICU, which has a function of interfacing the main computer with the CAMAC system, has been replaced with the workstation-based system after the fine tuning

Addressing the Digital Divide in Contemporary Biology: Lessons from Teaching UNIX.

Science.gov (United States)

Mangul, Serghei; Martin, Lana S; Hoffmann, Alexander; Pellegrini, Matteo; Eskin, Eleazar

2017-10-01

Life and medical science researchers increasingly rely on applications that lack a graphical interface. Scientists who are not trained in computer science face an enormous challenge analyzing high-throughput data. We present a training model for use of command-line tools when the learner has little to no prior knowledge of UNIX. Copyright © 2017 Elsevier Ltd. All rights reserved.

Sensing miRNA: Signal Amplification by Cognate RISC for Intracellular Detection of miRNA in Live Cells.

Science.gov (United States)

Kavishwar, Amol; Medarova, Zdravka

2016-01-01

The ability to detect miRNA expression in live cells would leave these cells available for further manipulation or culture. Here, we describe the design of a miRNA sensor oligonucleotide whose sequence mimics the target mRNA. The sensor has a fluorescent label on one end of the oligo and a quencher on the other. When inside the cell, the sensor is recognized by its cognate miRNA-RISC and gets cleaved, setting the fluorophore free from its quencher. This results in fluorescence "turn on." Since cleavage by the RISC complex is an enzymatic process, the described approach has a very high level of sensitivity (nM). The rate of nonspecific cleavage of the sensor is very slow permitting the collection of meaningful signal over a long period of time.

Integration of model-based control systems with artificial intelligence and workstations

International Nuclear Information System (INIS)

Lee, M.; Clearwater, S.

1987-01-01

Experience with model based accelerator control started at SPEAR. Since that SPEAR. Since that time nearly all accelerator beam lines have been controlled using model-based application programs, for example, PEP and SLC at SLAC. In order to take advantage of state-of-the-art hardware and software technology, the design and implementation of the accelerator control programs have undergone radical changes with time. Consequently, SPEAR, PEP, and SLC all use different control programs. Since many of these application programs are imbedded deep into the control system, they had to be rewritten each time. Each time this rewriting has occurred a great deal of time and effort has been spent on training physicists and programmers to do the job. Now, these application programs have been developed for a fourth time. This time, however, the programs being developed are generic so that they will not have to be done again. An integrated system called GOLD (Generic Orbit ampersand Lattice Debugger) has been developed for debugging and correcting trajectory errors in accelerator lattices. The system consists of a lattice modeling program (COMFORT), a beam simulator (PLUS), a graphical workstation environment (micro-VAX) and an expert system (ABLE). This paper will describe some of the features and applications of our integrated system with emphasis on the automation offered by expert systems. 5 refs., 4 figs

Computer programming and architecture the VAX

CERN Document Server

Levy, Henry

2014-01-01

Takes a unique systems approach to programming and architecture of the VAXUsing the VAX as a detailed example, the first half of this book offers a complete course in assembly language programming. The second describes higher-level systems issues in computer architecture. Highlights include the VAX assembler and debugger, other modern architectures such as RISCs, multiprocessing and parallel computing, microprogramming, caches and translation buffers, and an appendix on the Berkeley UNIX assembler.

A methodology to emulate and evaluate a productive virtual workstation

Science.gov (United States)

Krubsack, David; Haberman, David

1992-01-01

The Advanced Display and Computer Augmented Control (ADCACS) Program at ACT is sponsored by NASA Ames to investigate the broad field of technologies which must be combined to design a 'virtual' workstation for the Space Station Freedom. This program is progressing in several areas and resulted in the definition of requirements for a workstation. A unique combination of technologies at the ACT Laboratory have been networked to effectively create an experimental environment. This experimental environment allows the integration of nonconventional input devices with a high power graphics engine within the framework of an expert system shell which coordinates the heterogeneous inputs with the 'virtual' presentation. The flexibility of the workstation is evolved as experiments are designed and conducted to evaluate the condition descriptions and rule sets of the expert system shell and its effectiveness in driving the graphics engine. Workstation productivity has been defined by the achievable performance in the emulator of the calibrated 'sensitivity' of input devices, the graphics presentation, the possible optical enhancements to achieve a wide field of view color image and the flexibility of conditional descriptions in the expert system shell in adapting to prototype problems.

Supervisory Control Technique For An Assembly Workstation As A Dynamic Discrete Event System

Directory of Open Access Journals (Sweden)

Daniela Cristina CERNEGA

2001-12-01

Full Text Available This paper proposes a control problem statement in the framework of supervisory control technique for the assembly workstations. A desired behaviour of an assembly workstation is analysed. The behaviour of such a workstation is cyclic and some linguistic properties are established. In this paper, it is proposed an algorithm for the computation of the supremal controllable language of the closed system desired language. Copyright © 2001 IFAC.

A parallel solution to the cutting stock problem for a cluster of workstations

Energy Technology Data Exchange (ETDEWEB)

Nicklas, L.D.; Atkins, R.W.; Setia, S.V.; Wang, P.Y. [George Mason Univ., Fairfax, VA (United States)

1996-12-31

This paper describes the design and implementation of a solution to the constrained 2-D cutting stock problem on a cluster of workstations. The constrained 2-D cutting stock problem is an irregular problem with a dynamically modified global data set and irregular amounts and patterns of communication. A replicated data structure is used for the parallel solution since the ratio of reads to writes is known to be large. Mutual exclusion and consistency are maintained using a token-based lazy consistency mechanism, and a randomized protocol for dynamically balancing the distributed work queue is employed. Speedups are reported for three benchmark problems executed on a cluster of workstations interconnected by a 10 Mbps Ethernet.

Efficient Incremental Garbage Collection for Workstation/Server Database Systems

OpenAIRE

Amsaleg , Laurent; Gruber , Olivier; Franklin , Michael

1994-01-01

Projet RODIN; We describe an efficient server-based algorithm for garbage collecting object-oriented databases in a workstation/server environment. The algorithm is incremental and runs concurrently with client transactions, however, it does not hold any locks on data and does not require callbacks to clients. It is fault tolerant, but performs very little logging. The algorithm has been designed to be integrated into existing OODB systems, and therefore it works with standard implementation ...

Computer ray tracing speeds.

Science.gov (United States)

Robb, P; Pawlowski, B

1990-05-01

The results of measuring the ray trace speed and compilation speed of thirty-nine computers in fifty-seven configurations, ranging from personal computers to super computers, are described. A correlation of ray trace speed has been made with the LINPACK benchmark which allows the ray trace speed to be estimated using LINPACK performance data. The results indicate that the latest generation of workstations, using CPUs based on RISC (Reduced Instruction Set Computer) technology, are as fast or faster than mainframe computers in compute-bound situations.

76 FR 9012 - Access to Confidential Business Information by Electronic Consulting Services, Inc.

Science.gov (United States)

2011-02-16

... development for special projects; and maintain hardware and software inventory of workstations. In accordance.../maintenance of servers and operating system software (UNIX, Linux, Windows XP/2003/2000/NT); installing..., Information Management Division (7407M), Office of Pollution Prevention and Toxics, Environmental Protection...

System engineering workstations - critical tool in addressing waste storage, transportation, or disposal

International Nuclear Information System (INIS)

Mar, B.W.

1987-01-01

The ability to create, evaluate, operate, and manage waste storage, transportation, and disposal systems (WSTDSs) is greatly enhanced when automated tools are available to support the generation of the voluminous mass of documents and data associated with the system engineering of the program. A system engineering workstation is an optimized set of hardware and software that provides such automated tools to those performing system engineering functions. This paper explores the functions that need to be performed by a WSTDS system engineering workstation. While the latter stages of a major WSTDS may require a mainframe computer and specialized software systems, most of the required system engineering functions can be supported by a system engineering workstation consisting of a personnel computer and commercial software. These findings suggest system engineering workstations for WSTDS applications will cost less than $5000 per unit, and the payback on the investment can be realized in a few months. In most cases the major cost element is not the capital costs of hardware or software, but the cost to train or retrain the system engineers in the use of the workstation and to ensure that the system engineering functions are properly conducted

Introducing RISC: A New Video Inventory for Testing Social Perception.

Science.gov (United States)

Rothermich, Kathrin; Pell, Marc D

2015-01-01

Indirect forms of speech, such as sarcasm, jocularity (joking), and 'white lies' told to spare another's feelings, occur frequently in daily life and are a problem for many clinical populations. During social interactions, information about the literal or nonliteral meaning of a speaker unfolds simultaneously in several communication channels (e.g., linguistic, facial, vocal, and body cues); however, to date many studies have employed uni-modal stimuli, for example focusing only on the visual modality, limiting the generalizability of these results to everyday communication. Much of this research also neglects key factors for interpreting speaker intentions, such as verbal context and the relationship of social partners. Relational Inference in Social Communication (RISC) is a newly developed (English-language) database composed of short video vignettes depicting sincere, jocular, sarcastic, and white lie social exchanges between two people. Stimuli carefully manipulated the social relationship between communication partners (e.g., boss/employee, couple) and the availability of contextual cues (e.g. preceding conversations, physical objects) while controlling for major differences in the linguistic content of matched items. Here, we present initial perceptual validation data (N = 31) on a corpus of 920 items. Overall accuracy for identifying speaker intentions was above 80% correct and our results show that both relationship type and verbal context influence the categorization of literal and nonliteral interactions, underscoring the importance of these factors in research on speaker intentions. We believe that RISC will prove highly constructive as a tool in future research on social cognition, inter-personal communication, and the interpretation of speaker intentions in both healthy adults and clinical populations.

Impact of workstations on criticality analyses at ABB combustion engineering

International Nuclear Information System (INIS)

Tarko, L.B.; Freeman, R.S.; O'Donnell, P.F.

1993-01-01

During 1991, ABB Combustion Engineering (ABB C-E) made the transition from a CDC Cyber 990 mainframe for nuclear criticality safety analyses to Hewlett Packard (HP)/Apollo workstations. The primary motivation for this change was improved economics of the workstation and maintaining state-of-the-art technology. The Cyber 990 utilized the NOS operating system with a 60-bit word size. The CPU memory size was limited to 131 100 words of directly addressable memory with an extended 250000 words available. The Apollo workstation environment at ABB consists of HP/Apollo-9000/400 series desktop units used by most application engineers, networked with HP/Apollo DN10000 platforms that use 32-bit word size and function as the computer servers and network administrative CPUS, providing a virtual memory system

Files for workstations with ionizing radiation risks: variation in the use of gamma densitometers

International Nuclear Information System (INIS)

Tournadre, A.

2008-01-01

After a brief presentation of the different gamma-densitometers proposed by MLPC to measure roadway density, and having outlined the support role of the provider, the author describes the form and content of workstation files for workstations exhibiting a risk related to ionizing radiation. He gives an analytical overview of dose calculation: analysis of instrument use phases, exposure duration, dose rates and way of introducing these dose rates in the workstation file. He formulates how different procedures are to be followed by the radiation protection expert within the company. He outlines that workstation files are very useful as information feedback tool

Low Cost Desktop Image Analysis Workstation With Enhanced Interactive User Interface

Science.gov (United States)

Ratib, Osman M.; Huang, H. K.

1989-05-01

A multimodality picture archiving and communication system (PACS) is in routine clinical use in the UCLA Radiology Department. Several types workstations are currently implemented for this PACS. Among them, the Apple Macintosh II personal computer was recently chosen to serve as a desktop workstation for display and analysis of radiological images. This personal computer was selected mainly because of its extremely friendly user-interface, its popularity among the academic and medical community and its low cost. In comparison to other microcomputer-based systems the Macintosh II offers the following advantages: the extreme standardization of its user interface, file system and networking, and the availability of a very large variety of commercial software packages. In the current configuration the Macintosh II operates as a stand-alone workstation where images are imported from a centralized PACS server through an Ethernet network using a standard TCP-IP protocol, and stored locally on magnetic disk. The use of high resolution screens (1024x768 pixels x 8bits) offer sufficient performance for image display and analysis. We focused our project on the design and implementation of a variety of image analysis algorithms ranging from automated structure and edge detection to sophisticated dynamic analysis of sequential images. Specific analysis programs were developed for ultrasound images, digitized angiograms, MRI and CT tomographic images and scintigraphic images.

RISC-type microprocessors may revolutionize aerospace simulation

Science.gov (United States)

Jackson, Albert S.

The author explores the application of RISC (reduced instruction set computer) processors in massively parallel computer (MPC) designs for aerospace simulation. The MPC approach is shown to be well adapted to the needs of aerospace simulation. It is shown that any of the three common types of interconnection schemes used with MPCs are effective for general-purpose simulation, although the bus-or switch-oriented machines are somewhat easier to use. For partial differential equation models, the hypercube approach at first glance appears more efficient because the nearest-neighbor connections required for three-dimensional models are hardwired in a hypercube machine. However, the data broadcast ability of a bus system, combined with the fact that data can be transmitted over a bus as soon as it has been updated, makes the bus approach very competitive with the hypercube approach even for these types of models.

RISC-RAD. A European integrated approach to the problem of low doses

International Nuclear Information System (INIS)

Meunier, A.; Sabatier, L.; Atkinson, M.; Paretzke, H.; Bouffler, S.; Mullenders, L.

2007-01-01

Complete text of publication follows. Funded by the European Commission in the framework of a dedicated programme supporting research in the Nuclear sector (FP6 Euratom), the project RISC-RAD undertakes experimental and modelling studies ultimately to improve low dose radiation cancer risk assessment by exploring and providing evidence for the most appropriate radiation cancer risk projection and interpolation models. It started on 1st January 2004 and is running until 31 st October 2008. It mobilizes a consortium of 31 partners and is coordinated by Dr. Laure Sabatier from the French atomic energy commission. Indeed the project represents an unprecedented attempt to integrate horizontally the research on the effects of low doses of IR at the European level. A multipartner project supporting objective-driven research, RISC-RAD aims at contributing to bridge the remaining gap of scientific knowledge about effects of lows doses of ionizing radiation. It spans a large part of the research spectrum, including many topics addressed during the LOWRAD2007 conference. This presentation intends to give an account of the integrative aspects of the project, insights on the innovative solutions found to approach a complex and controversial scientific topic like the biological effects of low doses of ionizing radiation, and links with some areas of social studies on science.The concept of 'integration' implies the development of a new kind of activity in the research field, which crosses its traditional boundaries : controversies of several kinds must temporarily be overcome within the project management board in order to define and follow a common strategy. Among them, how to reconcile the creative part of fundamental research with the compliance to strict project planning rules has come up as a debate which questions the best way a significant collective and coordinated action can address the issue of the low dose cancer risk assessment on the long term. The knowledge and

Image sequence analysis workstation for multipoint motion analysis

Science.gov (United States)

Mostafavi, Hassan

1990-08-01

This paper describes an application-specific engineering workstation designed and developed to analyze motion of objects from video sequences. The system combines the software and hardware environment of a modem graphic-oriented workstation with the digital image acquisition, processing and display techniques. In addition to automation and Increase In throughput of data reduction tasks, the objective of the system Is to provide less invasive methods of measurement by offering the ability to track objects that are more complex than reflective markers. Grey level Image processing and spatial/temporal adaptation of the processing parameters is used for location and tracking of more complex features of objects under uncontrolled lighting and background conditions. The applications of such an automated and noninvasive measurement tool include analysis of the trajectory and attitude of rigid bodies such as human limbs, robots, aircraft in flight, etc. The system's key features are: 1) Acquisition and storage of Image sequences by digitizing and storing real-time video; 2) computer-controlled movie loop playback, freeze frame display, and digital Image enhancement; 3) multiple leading edge tracking in addition to object centroids at up to 60 fields per second from both live input video or a stored Image sequence; 4) model-based estimation and tracking of the six degrees of freedom of a rigid body: 5) field-of-view and spatial calibration: 6) Image sequence and measurement data base management; and 7) offline analysis software for trajectory plotting and statistical analysis.

UNIX trademark in high energy physics: What we can learn from the initial experiences at Fermilab

Energy Technology Data Exchange (ETDEWEB)

Butler, J.N.

1991-03-01

The reasons why Fermilab decided to support the UNIX operating system are reviewed and placed in the content of an overall model for high energy physics data analysis. The strengths and deficiencies of the UNIX environment for high energy physics are discussed. Fermilab's early experience in dealing with a an open'' multivendor environment, both for computers and for peripherals, is described. The human resources required to fully exploit the opportunities are clearly growing. The possibility of keeping the development and support efforts within reasonable bounds may depend on our ability to collaborate or at least to share information even more effectively than we have in the past. 7 refs., 4 figs., 5 tabs.

UNIX trademark in high energy physics: What we can learn from the initial experiences at Fermilab

International Nuclear Information System (INIS)

Butler, J.N.

1991-03-01

The reasons why Fermilab decided to support the UNIX operating system are reviewed and placed in the content of an overall model for high energy physics data analysis. The strengths and deficiencies of the UNIX environment for high energy physics are discussed. Fermilab's early experience in dealing with a an ''open'' multivendor environment, both for computers and for peripherals, is described. The human resources required to fully exploit the opportunities are clearly growing. The possibility of keeping the development and support efforts within reasonable bounds may depend on our ability to collaborate or at least to share information even more effectively than we have in the past. 7 refs., 4 figs., 5 tabs

LookOnX: A new technological approach for the H1 off-line event display

International Nuclear Information System (INIS)

Perus, A.; Arnault, C.

1994-01-01

The authors present the re-engineering work achieved on a traditional-fashioned GKS graphical package with new open-quotes event drivenclose quotes concepts required by using workstation interactivity. The Off-line Event Display for the H1 experiment H1look was originally written using a basic kernel package - Look - that provides a uniform control engine for graphical modules based on conventional GKS graphics. The use of powerful UNIX workstations is growing daily and their new graphical functionalities and CPU power are well suited to interactive graphical data analysis. Therefore re-engineering work was needed to put in some new features such as: interactive manipulations of graphical objects; object oriented definitions of the graphical representations and connectivity between graphical objects and physical objects; multi-windowing facility

Argo workstation: a key component of operational oceanography

Science.gov (United States)

Dong, Mingmei; Xu, Shanshan; Miao, Qingsheng; Yue, Xinyang; Lu, Jiawei; Yang, Yang

2018-02-01

Operational oceanography requires the quantity, quality, and availability of data set and the timeliness and effectiveness of data products. Without steady and strong operational system supporting, operational oceanography will never be proceeded far. In this paper we describe an integrated platform named Argo Workstation. It operates as a data processing and management system, capable of data collection, automatic data quality control, visualized data check, statistical data search and data service. After it is set up, Argo workstation provides global high quality Argo data to users every day timely and effectively. It has not only played a key role in operational oceanography but also set up an example for operational system.

Linear array implementation of the EM algorithm for PET image reconstruction

International Nuclear Information System (INIS)

Rajan, K.; Patnaik, L.M.; Ramakrishna, J.

1995-01-01

The PET image reconstruction based on the EM algorithm has several attractive advantages over the conventional convolution back projection algorithms. However, the PET image reconstruction based on the EM algorithm is computationally burdensome for today's single processor systems. In addition, a large memory is required for the storage of the image, projection data, and the probability matrix. Since the computations are easily divided into tasks executable in parallel, multiprocessor configurations are the ideal choice for fast execution of the EM algorithms. In tis study, the authors attempt to overcome these two problems by parallelizing the EM algorithm on a multiprocessor systems. The parallel EM algorithm on a linear array topology using the commercially available fast floating point digital signal processor (DSP) chips as the processing elements (PE's) has been implemented. The performance of the EM algorithm on a 386/387 machine, IBM 6000 RISC workstation, and on the linear array system is discussed and compared. The results show that the computational speed performance of a linear array using 8 DSP chips as PE's executing the EM image reconstruction algorithm is about 15.5 times better than that of the IBM 6000 RISC workstation. The novelty of the scheme is its simplicity. The linear array topology is expandable with a larger number of PE's. The architecture is not dependant on the DSP chip chosen, and the substitution of the latest DSP chip is straightforward and could yield better speed performance

SSCL-PDSF Data Management System

International Nuclear Information System (INIS)

Allen, J.L.

1992-09-01

Physics and detector simulations at the Superconducting Super Collider Laboratory (SSCL) are performed on a heterogeneous network of RISC based workstations named the Physics and Detector Simulation Facility (PDSF). These simulations can be characterized by the consumption and generation of large amounts of data. It is clear that on-line disk storage must be supplemented by off-line tape storage. For the PDSF, an 8-mm tape robot system was initially chosen in order to provide tertiary data storage based on its compactness and low cost. In order to manage this data, the Physics Computing Department designed the Data Management System (DMS)

Simulation model of a single-server order picking workstation using aggregate process times

NARCIS (Netherlands)

Andriansyah, R.; Etman, L.F.P.; Rooda, J.E.; Biles, W.E.; Saltelli, A.; Dini, C.

2009-01-01

In this paper we propose a simulation modeling approach based on aggregate process times for the performance analysis of order picking workstations in automated warehouses with first-in-first-out processing of orders. The aggregate process time distribution is calculated from tote arrival and

PC as physics computer for LHC?

International Nuclear Information System (INIS)

Jarp, Sverre; Simmins, Antony; Tang, Hong

1996-01-01

In the last five years, we have seen RISC workstations take over the computing scene that was once controlled by mainframes and supercomputers. In this paper we will argue that the same phenomenon might happen again. A project, active since March this year in the Physics Data Processing group of CERN's CN division is described where ordinary desktop PCs running Windows (NT and 3.11) have been used for creating an environment for running large LHC batch jobs (initially the DICE simulation job of Atlas). The problems encountered in porting both the CERN library and the specific Atlas codes are described together with some encouraging benchmark results when comparing to existing to existing RISC workstation in use by the Atlas collaboration. The issues of establishing the batch environment (Batch monitor, staging software, etc) are also covered. Finally a quick extrapolation of commodity computing power available in the future is touched upon to indicate what kind of cost envelope could be sufficient for the simulation farms required by the LHC experiments. (author)

Pc as Physics Computer for Lhc ?

Science.gov (United States)

Jarp, Sverre; Simmins, Antony; Tang, Hong; Yaari, R.

In the last five years, we have seen RISC workstations take over the computing scene that was once controlled by mainframes and supercomputers. In this paper we will argue that the same phenomenon might happen again. A project, active since March this year in the Physics Data Processing group, of CERN's CN division is described where ordinary desktop PCs running Windows (NT and 3.11) have been used for creating an environment for running large LHC batch jobs (initially the DICE simulation job of Atlas). The problems encountered in porting both the CERN library and the specific Atlas codes are described together with some encouraging benchmark results when comparing to existing RISC workstations in use by the Atlas collaboration. The issues of establishing the batch environment (Batch monitor, staging software, etc.) are also covered. Finally a quick extrapolation of commodity computing power available in the future is touched upon to indicate what kind of cost envelope could be sufficient for the simulation farms required by the LHC experiments.

Viewport: an object-oriented approach to integrate workstation software for tile and stack mode display.

Science.gov (United States)

Ghosh, S; Andriole, K P; Avrin, D E

1997-08-01

Diagnostic workstation design has migrated towards display presentation in one of two modes: tiled images or stacked images. It is our impression that the workstation setup or configuration in each of these two modes is rather distinct. We sought to establish a commonality to simplify software design, and to enable a single descriptor method to facilitate folder manager development of "hanging" protocols. All current workstation designs use a combination of "off-screen" and "on-screen" memory whether or not they use a dedicated display subsystem, or merely a video board. Most diagnostic workstations also have two or more monitors. Our central concept is that of a "logical" viewport that can be smaller than, the same size as, or larger than a single monitor. Each port "views" an image data sequence loaded into offscreen memory. Each viewport can display one or more images in sequence in a one-on-one or traditionally tiled presentation. Viewports can be assigned to the available monitor "real estate" in any manner that fits. For example, a single sequence computed tomography (CT) study could be displayed across all monitors in a tiled appearance by assigning a single large viewport to the monitors. At the other extreme, a multisequence magnetic resonance (MR) study could be compared with a similar previous study by assigning four viewports to each monitor, single image display per viewport, and assigning four of the sequences of the current study to the left monitor viewports, and four of the earlier study to the right monitor viewports. Ergonomic controls activate scrolling through the off-screen image sequence data. Workstation folder manager hanging protocols could then specify viewports, number of images per viewport, and the automatic assignment of appropriately named sequences of current and previous studies to the viewports on a radiologist-specific basis. Furthermore, software development is simplified by common base objects and methods of the tile and stack

Migration of nuclear criticality safety software from a mainframe to a workstation environment

International Nuclear Information System (INIS)

Bowie, L.J.; Robinson, R.C.; Cain, V.R.

1993-01-01

The Nuclear Criticality Safety Department (NCSD), Oak Ridge Y-12 Plant has undergone the transition of executing the Martin Marietta Energy Systems Nuclear Criticality Safety Software (NCSS) on IBM mainframes to a Hewlett-Packard (HP) 9000/730 workstation (NCSSHP). NCSSHP contains the following configuration controlled modules and cross-section libraries: BONAMI, CSAS, GEOMCHY, ICE, KENO IV, KENO Va, MODIIFY, NITAWL SCALE, SLTBLIB, XSDRN, UNIXLIB, albedos library, weights library, 16-Group HANSEN-ROACH master library, 27-Group ENDF/B-IV master library, and standard composition library. This paper will discuss the method used to choose the workstation, the hardware setup of the chosen workstation, an overview of Y-12 software quality assurance and configuration control methodology, code validation, difficulties encountered in migrating the codes, and advantages to migrating to a workstation environment

APS controls overview

International Nuclear Information System (INIS)

1996-01-01

The APS accelerator control system described in this report is a distributed system consisting of operator interfaces, a network, and interfaces to hardware. The operator interface is a UNIX-based workstation with an X-windows graphical user interface. The workstation may be located at any point on the facility network and maintain full functionality. The user has the ability to generate and alter control displays and to access the alarm handler, the archiver, interactive control programs, custom code, and other tools. The TCP/EP networking protocol has been selected as the underlying protocol for the control system network. TCP/EP is a commercial standard and readily available from network hardware vendors. Its implementation is independent of the particular network medium selected to implement the controls network. In the development environment copper Ethernet is the network medium; however, in the actual implementation a fiber-based system using hub technology will be utilized. The function of the network is to provide a generalized communication path between the host computers, operator workstations, input/output crates, and other hardware that comprise the control system

Microbial Disruption of Autophagy Alters Expression of the RISC Component AGO2, a Critical Regulator of the miRNA Silencing Pathway.

Science.gov (United States)

Sibony, Michal; Abdullah, Majd; Greenfield, Laura; Raju, Deepa; Wu, Ted; Rodrigues, David M; Galindo-Mata, Esther; Mascarenhas, Heidi; Philpott, Dana J; Silverberg, Mark S; Jones, Nicola L

2015-12-01

Autophagy is implicated in Crohn's disease (CD) pathogenesis. Recent evidence suggests autophagy regulates the microRNA (miRNA)-induced silencing complex (miRISC). Therefore, autophagy may play a novel role in CD by regulating expression of miRISC, thereby altering miRNA silencing. As microbes associated with CD can alter autophagy, we hypothesized that microbial disruption of autophagy affects the critical miRISC component AGO2. AGO2 expression was assessed in epithelial and immune cells, and intestinal organoids with disrupted autophagy. Microarray technology was used to determine the expression of downstream miRNAs in cells with defective autophagy. Increased AGO2 was detected in autophagy-deficient ATG5-/- and ATG16-/- mouse embryonic fibroblast cells (MEFs) in comparison with wild-type MEFs. Chemical agents and VacA toxin, which disrupt autophagy, increased AGO2 expression in MEFs, epithelial cells lines, and human monocytes, respectively. Increased AGO2 was also detected in ATG7-/- intestinal organoids, in comparison with wild-type organoids. Five miRNAs were differentially expressed in autophagy-deficient MEFs. Pathway enrichment analysis of the differentially expressed miRNAs implicated signaling pathways previously associated with CD. Taken together, our results suggest that autophagy is involved in the regulation of the critical miRISC component AGO2 in epithelial and immune cells and primary intestinal epithelial cells. We propose a mechanism by which autophagy alters miRNA expression, which likely impacts the regulation of CD-associated pathways. Furthermore, as enteric microbial products can manipulate autophagy and AGO2, our findings suggest a novel mechanism by which enteric microbes could influence miRNA to promote disease.

Image manipulation software portable on different hardware platforms: what is the cost?

Science.gov (United States)

Ligier, Yves; Ratib, Osman M.; Funk, Matthieu; Perrier, Rene; Girard, Christian; Logean, Marianne

1992-07-01

A hospital wide PACS project is currently under development at the University Hospital of Geneva. The visualization and manipulation of images provided by different imaging modalities constitutes one of the most challenging components of a PACS. Because there are different requirements depending on the clinical usage, it was necessary for such a visualization software to be provided on different types of workstations in different sectors of the PACS. The user interface has to be the same independently of the underlying workstation. Beside, in addition to a standard set of image manipulation and processing tools there is a need for more specific clinical tools that should be easily adapted to specific medical requirements. To achieve operating and windowing systems: the standard Unix/X-11/OSF-Motif based workstations and the Macintosh family and should be easily ported on other systems. This paper describes the design of such a system and discusses the extra cost and efforts involved in the development of a portable and easily expandable software.

Introducing RISC: A New Video Inventory for Testing Social Perception.

Directory of Open Access Journals (Sweden)

Kathrin Rothermich

Full Text Available Indirect forms of speech, such as sarcasm, jocularity (joking, and 'white lies' told to spare another's feelings, occur frequently in daily life and are a problem for many clinical populations. During social interactions, information about the literal or nonliteral meaning of a speaker unfolds simultaneously in several communication channels (e.g., linguistic, facial, vocal, and body cues; however, to date many studies have employed uni-modal stimuli, for example focusing only on the visual modality, limiting the generalizability of these results to everyday communication. Much of this research also neglects key factors for interpreting speaker intentions, such as verbal context and the relationship of social partners. Relational Inference in Social Communication (RISC is a newly developed (English-language database composed of short video vignettes depicting sincere, jocular, sarcastic, and white lie social exchanges between two people. Stimuli carefully manipulated the social relationship between communication partners (e.g., boss/employee, couple and the availability of contextual cues (e.g. preceding conversations, physical objects while controlling for major differences in the linguistic content of matched items. Here, we present initial perceptual validation data (N = 31 on a corpus of 920 items. Overall accuracy for identifying speaker intentions was above 80% correct and our results show that both relationship type and verbal context influence the categorization of literal and nonliteral interactions, underscoring the importance of these factors in research on speaker intentions. We believe that RISC will prove highly constructive as a tool in future research on social cognition, inter-personal communication, and the interpretation of speaker intentions in both healthy adults and clinical populations.

A Low-Cost PC-Based Image Workstation for Dynamic Interactive Display of Three-Dimensional Anatomy

Science.gov (United States)

Barrett, William A.; Raya, Sai P.; Udupa, Jayaram K.

1989-05-01

A system for interactive definition, automated extraction, and dynamic interactive display of three-dimensional anatomy has been developed and implemented on a low-cost PC-based image workstation. An iconic display is used for staging predefined image sequences through specified increments of tilt and rotation over a solid viewing angle. Use of a fast processor facilitates rapid extraction and rendering of the anatomy into predefined image views. These views are formatted into a display matrix in a large image memory for rapid interactive selection and display of arbitrary spatially adjacent images within the viewing angle, thereby providing motion parallax depth cueing for efficient and accurate perception of true three-dimensional shape, size, structure, and spatial interrelationships of the imaged anatomy. The visual effect is that of holding and rotating the anatomy in the hand.

A versatile nondestructive evaluation imaging workstation

Science.gov (United States)

Chern, E. James; Butler, David W.

1994-01-01

Ultrasonic C-scan and eddy current imaging systems are of the pointwise type evaluation systems that rely on a mechanical scanner to physically maneuver a probe relative to the specimen point by point in order to acquire data and generate images. Since the ultrasonic C-scan and eddy current imaging systems are based on the same mechanical scanning mechanisms, the two systems can be combined using the same PC platform with a common mechanical manipulation subsystem and integrated data acquisition software. Based on this concept, we have developed an IBM PC-based combined ultrasonic C-scan and eddy current imaging system. The system is modularized and provides capacity for future hardware and software expansions. Advantages associated with the combined system are: (1) eliminated duplication of the computer and mechanical hardware, (2) unified data acquisition, processing and storage software, (3) reduced setup time for repetitious ultrasonic and eddy current scans, and (4) improved system efficiency. The concept can be adapted to many engineering systems by integrating related PC-based instruments into one multipurpose workstation such as dispensing, machining, packaging, sorting, and other industrial applications.

Temporal digital subtraction radiography with a personal computer digital workstation

International Nuclear Information System (INIS)

Kircos, L.; Holt, W.; Khademi, J.

1990-01-01

Technique have been developed and implemented on a personal computer (PC)-based digital workstation to accomplish temporal digital subtraction radiography (TDSR). TDSR is useful in recording radiologic change over time. Thus, this technique is useful not only for monitoring chronic disease processes but also for monitoring the temporal course of interventional therapies. A PC-based digital workstation was developed on a PC386 platform with add-in hardware and software. Image acquisition, storage, and processing was accomplished using 512 x 512 x 8- or 12-bit frame grabber. Software and hardware were developed to accomplish image orientation, registration, gray scale compensation, subtraction, and enhancement. Temporal radiographs of the jaws were made in a fixed and reproducible orientation between the x-ray source and image receptor enabling TDSR. Temporal changes secondary to chronic periodontal disease, osseointegration of endosseous implants, and wound healing were demonstrated. Use of TDSR for chest imaging was also demonstrated with identification of small, subtle focal masses that were not apparent with routine viewing. The large amount of radiologic information in images of the jaws and chest may obfuscate subtle changes that TDSR seems to identify. TDSR appears to be useful as a tool to record temporal and subtle changes in radiologic images

Non-contact methods for NDT of aeronautical structures : An image processing workstation for thermography

OpenAIRE

Azzarelli, Luciano; Chimenti, Massimo; Salvetti, Ovidio

1992-01-01

The main goals of the Istituto di Elaborazione della Informazione in Task 4., Subtasks 4.3.1 (Image Processing) and 4.3.2 (Workstation Architecture) were the study of thermograms features, the design of the architecture of a customized workstation and the project of specialized algorithms for thermal image analysis. Thermograms features pertain to data acquisition, data archiving and data processing; following general study some basic requirements for the workstation were defined. "Data acqui...

Parallel computing for event reconstruction in high-energy physics

International Nuclear Information System (INIS)

Wolbers, S.

1993-01-01

Parallel computing has been recognized as a solution to large computing problems. In High Energy Physics offline event reconstruction of detector data is a very large computing problem that has been solved with parallel computing techniques. A review of the parallel programming package CPS (Cooperative Processes Software) developed and used at Fermilab for offline reconstruction of Terabytes of data requiring the delivery of hundreds of Vax-Years per experiment is given. The Fermilab UNIX farms, consisting of 180 Silicon Graphics workstations and 144 IBM RS6000 workstations, are used to provide the computing power for the experiments. Fermilab has had a long history of providing production parallel computing starting with the ACP (Advanced Computer Project) Farms in 1986. The Fermilab UNIX Farms have been in production for over 2 years with 24 hour/day service to experimental user groups. Additional tools for management, control and monitoring these large systems will be described. Possible future directions for parallel computing in High Energy Physics will be given

Shoulder girdle muscle activity and fatigue in traditional and improved design carpet weaving workstations.

Science.gov (United States)

Allahyari, Teimour; Mortazavi, Narges; Khalkhali, Hamid Reza; Sanjari, Mohammad Ali

2016-01-01

Work-related musculoskeletal disorders in the neck and shoulder regions are common among carpet weavers. Working for prolonged hours in a static and awkward posture could result in an increased muscle activity and may lead to musculoskeletal disorders. Ergonomic workstation improvements can reduce muscle fatigue and the risk of musculoskeletal disorders. The aim of this study is to assess and to compare upper trapezius and middle deltoid muscle activity in 2 traditional and improved design carpet weaving workstations. These 2 workstations were simulated in a laboratory and 12 women carpet weavers worked for 3 h. Electromyography (EMG) signals were recorded during work in bilateral upper trapezius and bilateral middle deltoid. The root mean square (RMS) and median frequency (MF) values were calculated and used to assess muscle load and fatigue. Repeated measure ANOVA was performed to assess the effect of independent variables on muscular activity and fatigue. The participants were asked to report shoulder region fatigue on the Borg's Category-Ratio scale (Borg CR-10). Root mean square values in workstation A are significantly higher than in workstation B. Furthermore, EMG amplitude was higher in bilateral trapezius than in bilateral deltoid. However, muscle fatigue was not observed in any of the workstations. The results of the study revealed that muscle load in a traditional workstation was high, but fatigue was not observed. Further studies investigating other muscles involved in carpet weaving tasks are recommended. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

Interfacing ANSYS to user's programs using UNIX shell program

Energy Technology Data Exchange (ETDEWEB)

Kim, In Yong; Kim, Beom Shig [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

1994-01-01

It has been considered to be impossible to interface the ANSYS, which is the commercial finite element code and whose program is not open to public, to the other user's program. When the analysis need to be iterated, the user should wait until the analysis is finished and read the ANSYS result to make the input data for every iteration. In this report the direct interfacing techniques between the ANSYS and the other program using UNIX shell programming are proposed. The detail program lists and the application example are also provided. (Author) 19 refs., 6 figs., 7 tabs.

40 CFR 86.1312-2007 - Filter stabilization and microbalance workstation environmental conditions, microbalance...

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Filter stabilization and microbalance workstation environmental conditions, microbalance specifications, and particulate matter filter handling and... Particulate Exhaust Test Procedures § 86.1312-2007 Filter stabilization and microbalance workstation...

BioPhotonics Workstation: 3D interactive manipulation, observation and characterization

DEFF Research Database (Denmark)

Glückstad, Jesper

2011-01-01

In ppo.dk we have invented the BioPhotonics Workstation to be applied in 3D research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and new materials.......In ppo.dk we have invented the BioPhotonics Workstation to be applied in 3D research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and new materials....

GOLD: Integration of model-based control systems with artificial intelligence and workstations

International Nuclear Information System (INIS)

Lee, M.; Clearwater, S.

1987-08-01

Our experience with model based accelerator control started at SPEAR. Since that time nearly all accelerator beam lines have been controlled using model-based application programs, for example, PEP and SLC at SLAC. In order to take advantage of state-of-the-art hardware and software technology, the design and implementation of the accelerator control programs have undergone radical change with time. Consequently, SPEAR, PEP, and SLC all use different control programs. Since many of these application programs are imbedded deep into the control system, they had to be rewritten each time. Each time this rewriting has occurred a great deal of time and effort has been spent on training physicists and programmers to do the job. Now, we have developed these application programs for a fourth time. This time, however, the programs we are developing are generic so that we will not have to do it again. We have developed an integrated system called GOLD (Generic Orbit and Lattice Debugger) for debugging and correcting trajectory errors in accelerator lattices. The system consists of a lattice modeling program (COMFORT), a beam simulator (PLUS), a graphical workstation environment (micro-VAX) and an expert system (ABLE). This paper will describe some of the features and applications of our integrated system with emphasis on the automation offered by expert systems. 5 refs

Functional analysis of neuronal microRNAs in Caenorhabditis elegans dauer formation by combinational genetics and Neuronal miRISC immunoprecipitation.

Directory of Open Access Journals (Sweden)

Minh T Than

2013-06-01

Full Text Available Identifying the physiological functions of microRNAs (miRNAs is often challenging because miRNAs commonly impact gene expression under specific physiological conditions through complex miRNA::mRNA interaction networks and in coordination with other means of gene regulation, such as transcriptional regulation and protein degradation. Such complexity creates difficulties in dissecting miRNA functions through traditional genetic methods using individual miRNA mutations. To investigate the physiological functions of miRNAs in neurons, we combined a genetic "enhancer" approach complemented by biochemical analysis of neuronal miRNA-induced silencing complexes (miRISCs in C. elegans. Total miRNA function can be compromised by mutating one of the two GW182 proteins (AIN-1, an important component of miRISC. We found that combining an ain-1 mutation with a mutation in unc-3, a neuronal transcription factor, resulted in an inappropriate entrance into the stress-induced, alternative larval stage known as dauer, indicating a role of miRNAs in preventing aberrant dauer formation. Analysis of this genetic interaction suggests that neuronal miRNAs perform such a role partly by regulating endogenous cyclic guanosine monophosphate (cGMP signaling, potentially influencing two other dauer-regulating pathways. Through tissue-specific immunoprecipitations of miRISC, we identified miRNAs and their likely target mRNAs within neuronal tissue. We verified the biological relevance of several of these miRNAs and found that many miRNAs likely regulate dauer formation through multiple dauer-related targets. Further analysis of target mRNAs suggests potential miRNA involvement in various neuronal processes, but the importance of these miRNA::mRNA interactions remains unclear. Finally, we found that neuronal genes may be more highly regulated by miRNAs than intestinal genes. Overall, our study identifies miRNAs and their targets, and a physiological function of these miRNAs in

Multi-objective optimization algorithms for mixed model assembly line balancing problem with parallel workstations

Directory of Open Access Journals (Sweden)

Masoud Rabbani

2016-12-01

Full Text Available This paper deals with mixed model assembly line (MMAL balancing problem of type-I. In MMALs several products are made on an assembly line while the similarity of these products is so high. As a result, it is possible to assemble several types of products simultaneously without any additional setup times. The problem has some particular features such as parallel workstations and precedence constraints in dynamic periods in which each period also effects on its next period. The research intends to reduce the number of workstations and maximize the workload smoothness between workstations. Dynamic periods are used to determine all variables in different periods to achieve efficient solutions. A non-dominated sorting genetic algorithm (NSGA-II and multi-objective particle swarm optimization (MOPSO are used to solve the problem. The proposed model is validated with GAMS software for small size problem and the performance of the foregoing algorithms is compared with each other based on some comparison metrics. The NSGA-II outperforms MOPSO with respect to some comparison metrics used in this paper, but in other metrics MOPSO is better than NSGA-II. Finally, conclusion and future research is provided.

The impact of sit-stand office workstations on worker discomfort and productivity: a review.

Science.gov (United States)

Karakolis, Thomas; Callaghan, Jack P

2014-05-01

This review examines the effectiveness of sit-stand workstations at reducing worker discomfort without causing a decrease in productivity. Four databases were searched for studies on sit-stand workstations, and five selection criteria were used to identify appropriate articles. Fourteen articles were identified that met at least three of the five selection criteria. Seven of the identified studies reported either local, whole body or both local and whole body subjective discomfort scores. Six of these studies indicated implementing sit-stand workstations in an office environment led to lower levels of reported subjective discomfort (three of which were statistically significant). Therefore, this review concluded that sit-stand workstations are likely effective in reducing perceived discomfort. Eight of the identified studies reported a productivity outcome. Three of these studies reported an increase in productivity during sit-stand work, four reported no affect on productivity, and one reported mixed productivity results. Therefore, this review concluded that sit-stand workstations do not cause a decrease in productivity. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

Comparison of computer workstation with light box for detecting setup errors from portal images

International Nuclear Information System (INIS)

Boxwala, Aziz A.; Chaney, Edward L.; Fritsch, Daniel S.; Raghavan, Suraj; Coffey, Christopher S.; Major, Stacey A.; Muller, Keith E.

1999-01-01

Purpose: Observer studies were conducted to test the hypothesis that radiation oncologists using a computer workstation for portal image analysis can detect setup errors at least as accurately as when following standard clinical practice of inspecting portal films on a light box. Methods and Materials: In a controlled observer study, nine radiation oncologists used a computer workstation, called PortFolio, to detect setup errors in 40 realistic digitally reconstructed portal radiograph (DRPR) images. PortFolio is a prototype workstation for radiation oncologists to display and inspect digital portal images for setup errors. PortFolio includes tools for image enhancement; alignment of crosshairs, field edges, and anatomic structures on reference and acquired images; measurement of distances and angles; and viewing registered images superimposed on one another. The test DRPRs contained known in-plane translation or rotation errors in the placement of the fields over target regions in the pelvis and head. Test images used in the study were also printed on film for observers to view on a light box and interpret using standard clinical practice. The mean accuracy for error detection for each approach was measured and the results were compared using repeated measures analysis of variance (ANOVA) with the Geisser-Greenhouse test statistic. Results: The results indicate that radiation oncologists participating in this study could detect and quantify in-plane rotation and translation errors more accurately with PortFolio compared to standard clinical practice. Conclusions: Based on the results of this limited study, it is reasonable to conclude that workstations similar to PortFolio can be used efficaciously in clinical practice

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

VME processors under VxWorks, a real time operating system, manage the fieldbus, concentrate the accelerator information and transmit it to the supervisory software through the ethernet network. This software consists of a collection of Java virtual machines (JVM) running on several Unix work-stations and PCs under ...

ISDN communication: Its workstation technology and application system

Energy Technology Data Exchange (ETDEWEB)

Sugimura, T; Ogiwara, Y; Saito, T [Hitachi, Ltd., Tokyo (Japan)

1991-07-01

This report describes technology for integrated services digital network (ISDN) which allows workstations to process multimedia data and application systems of advanced group teleworking which use such technology. Hitachi has developed workstations which are more powerful, have more functions, and have larger memory capacities. These factors allowed media which require high-speed processing of large quantities of voice and image data to be integrated into the world of conventional text data processing and communications. In addition, the application of group teleworking system has a large impact through the improvements in the office environment, the changes in the style of office work, and the appearance of new businesses. A prototype of this system was exhibited and demonstrated at TELECOM91. 1 ref., 4 figs., 2 tabs.

Virtual interface environment workstations

Science.gov (United States)

Fisher, S. S.; Wenzel, E. M.; Coler, C.; Mcgreevy, M. W.

1988-01-01

A head-mounted, wide-angle, stereoscopic display system controlled by operator position, voice and gesture has been developed at NASA's Ames Research Center for use as a multipurpose interface environment. This Virtual Interface Environment Workstation (VIEW) system provides a multisensory, interactive display environment in which a user can virtually explore a 360-degree synthesized or remotely sensed environment and can viscerally interact with its components. Primary applications of the system are in telerobotics, management of large-scale integrated information systems, and human factors research. System configuration, research scenarios, and research directions are described.

Flow time prediction for a single-server order picking workstation using aggregate process times

NARCIS (Netherlands)

Andriansyah, R.; Etman, L.F.P.; Rooda, J.E.

2010-01-01

In this paper we propose a simulation modeling approach based on aggregate process times for the performance analysis of order picking workstations in automated warehouses. The aggregate process time distribution is calculated from tote arrival and departure times. We refer to the aggregate process

With Unix under the hood, the Mac has a toehold in the geophysical sector

Energy Technology Data Exchange (ETDEWEB)

Roche, P.

2004-05-01

A new lease on life in the geophysical sector is predicted for Apple Computer as result of the company's decision first to convert to the Unix System, and then to develop a new operating system called OS X (O-S-Ten) which runs under a version of Unix called Free BSD. While Apple shows no indication of interest to market its hardware and software to the oil industry, at least one oil company, Houston-based Seitel Inc., is using Apple products for its high performance computing and technical desktop applications, such as storing its onshore and offshore 3-D seismic data on Apple's Xserve RAID rack storage system. In another application, Virginia Polytechnic Institute built a supercomputer using 1,100 64-bit G5 Power Macs. The result is the third fastest super-computer in the world, running at a blazing 10.28 teraflops, or 10.28 trillion calculations per second. By all accounts, it is well suited to oilpatch tasks such as seismic data processing and running large-scale simulations such as fluid flow through porous media. Seitel is also interested in Apple's 64-bit G5 computers to run its seismic data processing operations which require large amounts of computing power. While Apple's hardware and software appear to be well adopted to perform oilpatch tasks, proliferation of use of Apple products by oilpatch companies is hindered by the almost complete absence of oilpatch software. Parallel Geoscience Corporation which had long been interested in creating Mac-based software for geoscience applications, is in the process of filling that gap by refocusing its attention on an O-S-Ten version of its Seismic Precessing Workshop{sup T}M{sup (}SPW). How long it will take to make the conversion will depend on customer demand. 2 figs.

FORTRAN data files transference from VAX/VMS to ALPHA/UNIX

International Nuclear Information System (INIS)

Sanchez, E.; Milligen, B.Ph. van

1997-01-01

Several tools have been developed to access the TJ-I and TJ-IU databases, which currently reside in VAX/VMS servers, from the TJ-II Data Acquisition System DEC ALPHA 8400 server. The TJ-I/TJ-IU databases are not homogeneous and contain several types of data files, namely, SADE. CAMAC and FORTRAN un formatted files. The tools presented in this report allow one to transfer CAMAC and those FORTRAN un formatted files defined herein. from a VAX/VMS server, for data manipulation on the ALPHA/Digital UNIX server. (Author) 5 refs

Experiments with general purpose visualization software on a unix workstation

International Nuclear Information System (INIS)

Adam, G.

1995-10-01

A study was performed on the opportunity of buying, for the ICTP use, one of the following visualization systems: Advanced Visualization Systems (AVS) - release 5.02 IRIS Explorer - release 2.2 from NAG IBM Data Explorer (DX) - release 2.1.5 Khoros - Developer's Release 2.0+p2. Criteria for an optimal choice were defined and it was concluded that none of these visualization systems would be a good today compromise. Conservative consideration of the market opportunities shows that substantially improved releases of these systems are expected to be operational within at most an year. For short term period, the ratio benefit to burden still makes public domain low-end graphics attractive. (author)

Experiments with general purpose visualization software on a unix workstation

Energy Technology Data Exchange (ETDEWEB)

Adam, G

1995-10-01

A study was performed on the opportunity of buying, for the ICTP use, one of the following visualization systems: Advanced Visualization Systems (AVS) - release 5.02 IRIS Explorer - release 2.2 from NAG IBM Data Explorer (DX) - release 2.1.5 Khoros - Developer`s Release 2.0+p2. Criteria for an optimal choice were defined and it was concluded that none of these visualization systems would be a good today compromise. Conservative consideration of the market opportunities shows that substantially improved releases of these systems are expected to be operational within at most an year. For short term period, the ratio benefit to burden still makes public domain low-end graphics attractive. (author).

Digital optical interconnects for photonic computing

Science.gov (United States)

Guilfoyle, Peter S.; Stone, Richard V.; Zeise, Frederick F.

1994-05-01

A 32-bit digital optical computer (DOC II) has been implemented in hardware utilizing 8,192 free-space optical interconnects. The architecture exploits parallel interconnect technology by implementing microcode at the primitive level. A burst mode of 0.8192 X 1012 binary operations per sec has been reliably demonstrated. The prototype has been successful in demonstrating general purpose computation. In addition to emulating the RISC instruction set within the UNIX operating environment, relational database text search operations have been implemented on DOC II.

Effect of One Carpet Weaving Workstation on Upper Trapezius Fatigue

Directory of Open Access Journals (Sweden)

Neda Mahdavi

2016-03-01

Full Text Available Introduction: This study aimed to investigate the effect of carpet weaving at a proposed workstation on Upper Trapezius (UTr fatigue during a task cycle. Fatigue in the shoulder is one of the most important precursors for upper limb musculoskeletal disorders. One of the most prevalent musculoskeletal disorders between carpet weavers is disorder of the shoulder region. Methods: This cross-sectional study, included eight females and three males. During an 80-minute cycle of carpet weaving, Electromyography (EMG signals of right and left UTr were recorded by the surface EMG, continuously. After raw signals were processed, MPF and RMS were considered as EMG amplitude and frequency parameters. Time series model and JASA methods were used to assess and classify the EMG parameter changes during the working time. Results: According to the JASA method, 58%, 16%, 8% and 8% of the participants experienced fatigue, force increase, force decrease and recovery, respectively in the right UTr. Also, 50%, 25%, 8% and 16% of the participants experienced fatigue, force increase, force decrease and recovery, respectively in the left UTr. Conclusions: For the major portion of the weavers, dominant status in Left and right UTr was fatigue, at the proposed workstation during a carpet weaving task cycle. The results of the study provide detailed information for optimal design of workstations. Further studies should focus on fatigue in various muscles and time periods for designing an appropriate and ergonomics carpet weaving workstation

Exporting Variables in a Hierarchically Distributed Control System

Energy Technology Data Exchange (ETDEWEB)

Chamizo Llatas, M

1995-07-01

We describe the Remote Variable Access Service (RVAS), a network service developed and used in the distributed control and monitoring system of the TJ-II Heliac, which is under construction at CIEMAT (Madrid, Spain) and devoted to plasma studies in the nuclear fusion field. The architecture of the TJ-II control system consists of one central Sun workstation Sparc 10 and several autonomous subsystems based on VME crates with embedded processors running the OS-9 (V.24) real time operating system. The RVAS service allows state variables in local control processes running in subsystems to be exported to remote processes running in the central control workstation. Thus we extend the concept of exporting of file systems in UNIX machines to variables in processes running in different machines. (Author) 6 refs.

Exporting Variables in a Hierarchically Distributed Control System

International Nuclear Information System (INIS)

Diaz Martin; Martinez Laso, L.

1995-01-01

We describe the Remote Variable Access Service (RVAS), a network service developed and use in the distributed control and monitoring system of the TJ-II Heliac, which is under construction at CIEMAT (Madrid, Spain) and devoted to plasma studies in the nuclear fusion field. The architecture of the TJ-II control system consists of one central Sun workstation Sparc 10 and several autonomous subsystems based on VME crates with embedded processors running the os-9 (V.24) real time operating system. The RVAS service allows state variables in local control processes running in subsystems to be exported to remote processes running in the central control workstation. Thus we extend the concept of exporting of file systems in UNIX machines to variables in processes running in different machines. (Author)

Exporting Variables in a Hierarchically Distributed Control System

International Nuclear Information System (INIS)

Chamizo Llatas, M.

1995-01-01

We describe the Remote Variable Access Service (RVAS), a network service developed and used in the distributed control and monitoring system of the TJ-II Heliac, which is under construction at CIEMAT (Madrid, Spain) and devoted to plasma studies in the nuclear fusion field. The architecture of the TJ-II control system consists of one central Sun workstation Sparc 10 and several autonomous subsystems based on VME crates with embedded processors running the OS-9 (V.24) real time operating system. The RVAS service allows state variables in local control processes running in subsystems to be exported to remote processes running in the central control workstation. Thus we extend the concept of exporting of file systems in UNIX machines to variables in processes running in different machines. (Author) 6 refs

Context Switching with Multiple Register Windows: A RISC Performance Study

Science.gov (United States)

Konsek, Marion B.; Reed, Daniel A.; Watcharawittayakul, Wittaya

1987-01-01

Although previous studies have shown that a large file of overlapping register windows can greatly reduce procedure call/return overhead, the effects of register windows in a multiprogramming environment are poorly understood. This paper investigates the performance of multiprogrammed, reduced instruction set computers (RISCs) as a function of window management strategy. Using an analytic model that reflects context switch and procedure call overheads, we analyze the performance of simple, linearly self-recursive programs. For more complex programs, we present the results of a simulation study. These studies show that a simple strategy that saves all windows prior to a context switch, but restores only a single window following a context switch, performs near optimally.

Helical computed tomography and the workstation: introduction to a symbiosis

International Nuclear Information System (INIS)

Garcia-Santos, J.M.

1997-01-01

We do a brief introduction to the possibilities of an helical computed tomography system when it is associated with a powerful workstation. The fast and volumetric way of acquisition constitutes, basically, the main advantage of this sort of computed tomography. The anatomical and radio pathological study, in a workstation, of the acquired information (thanks to multiplanar and 3D reconstruction), increases significantly our capacity of analysis in each patient. Only the clinical and radiological experience will tell us which is the right place that this symbiosis occupies within our diagnosis tools. (Author) 11 refs

Effect of immediate feedback training on observer performance on a digital radiology workstation

International Nuclear Information System (INIS)

Mc Neill, K.M.; Maloney, K.; Elam, E.A.; Hillman, B.J.; Witzke, D.B.

1990-01-01

This paper reports on testing the hypothesis that training radiologists on a digital workstation would affect their efficiency and subjective acceptance of radiologic interpretation based on images shown on a cathode ray tub (CRT). Using a digital radiology workstation, six faculty radiologists and four senior residents read seven groups of six images each. In each group, three images were ranked as easy and three were ranked as difficult. All images were abnormal posteroanterior chest radiographs. On display of each image, the observer was asked which findings were present. After the observer listed his or her findings, the experimenter listed any findings not mentioned and pointed out any incorrect findings. The time to finding was recorded for each image, along with the number of corrections and missed findings. A postexperiment questionnaire was given to obtain subjective responses from the observers

76 FR 10403 - Hewlett Packard (HP), Global Product Development, Engineering Workstation Refresh Team, Working...

Science.gov (United States)

2011-02-24

...), Global Product Development, Engineering Workstation Refresh Team, Working On-Site at General Motors..., Non-Information Technology Business Development Team and Engineering Application Support Team, working... Hewlett Packard, Global Product Development, Engineering Workstation Refresh Team, working on-site at...

Desk-based workers' perspectives on using sit-stand workstations: a qualitative analysis of the Stand@Work study

NARCIS (Netherlands)

Chau, J.Y.; Daley, M.; Srinivasan, A.; Dunn, S.; Bauman, A.E.; van der Ploeg, H.P.

2014-01-01

Background: Prolonged sitting time has been identified as a health risk factor. Sit-stand workstations allow desk workers to alternate between sitting and standing throughout the working day, but not much is known about their acceptability and feasibility. Hence, the aim of this study was to

A nuclear power plant system engineering workstation

International Nuclear Information System (INIS)

Mason, J.H.; Crosby, J.W.

1989-01-01

System engineers offer an approach for effective technical support for operation and maintenance of nuclear power plants. System engineer groups are being set up by most utilities in the United States. Institute of Nuclear Power operations (INPO) and U.S. Nuclear Regulatory Commission (NRC) have endorsed the concept. The INPO Good Practice and a survey of system engineer programs in the southeastern United States provide descriptions of system engineering programs. The purpose of this paper is to describe a process for developing a design for a department-level information network of workstations for system engineering groups. The process includes the following: (1) application of a formal information engineering methodology, (2) analysis of system engineer functions and activities; (3) use of Electric Power Research Institute (EPRI) Plant Information Network (PIN) data; (4) application of the Information Engineering Workbench. The resulting design for this system engineer workstation can provide a reference for design of plant-specific systems

Parallel Computation of Unsteady Flows on a Network of Workstations

Science.gov (United States)

1997-01-01

Parallel computation of unsteady flows requires significant computational resources. The utilization of a network of workstations seems an efficient solution to the problem where large problems can be treated at a reasonable cost. This approach requires the solution of several problems: 1) the partitioning and distribution of the problem over a network of workstation, 2) efficient communication tools, 3) managing the system efficiently for a given problem. Of course, there is the question of the efficiency of any given numerical algorithm to such a computing system. NPARC code was chosen as a sample for the application. For the explicit version of the NPARC code both two- and three-dimensional problems were studied. Again both steady and unsteady problems were investigated. The issues studied as a part of the research program were: 1) how to distribute the data between the workstations, 2) how to compute and how to communicate at each node efficiently, 3) how to balance the load distribution. In the following, a summary of these activities is presented. Details of the work have been presented and published as referenced.

User interface on networked workstations for MFTF plasma diagnostic instruments

International Nuclear Information System (INIS)

Renbarger, V.L.; Balch, T.R.

1985-01-01

A network of Sun-2/170 workstations is used to provide an interface to the MFTF-B Plasma Diagnostics System at Lawrence Livermore National Laboratory. The Plasma Diagnostics System (PDS) is responsible for control of MFTF-B plasma diagnostic instrumentation. An EtherNet Local Area Network links the workstations to a central multiprocessing system which furnishes data processing, data storage and control services for PDS. These workstations permit a physicist to command data acquisition, data processing, instrument control, and display of results. The interface is implemented as a metaphorical desktop, which helps the operator form a mental model of how the system works. As on a real desktop, functions are provided by sheets of paper (windows on a CRT screen) called worksheets. The worksheets may be invoked by pop-up menus and may be manipulated with a mouse. These worksheets are actually tasks that communicate with other tasks running in the central computer system. By making entries in the appropriate worksheet, a physicist may specify data acquisition or processing, control a diagnostic, or view a result

RNAi and retroviruses: are they in RISC?

Science.gov (United States)

Vasselon, Thierry; Bouttier, Manuella; Saumet, Anne; Lecellier, Charles-Henri

2013-02-01

RNA interference (RNAi) is a potent cellular system against viruses in various organisms. Although common traits are observed in plants, insects, and nematodes, the situation observed in mammals appears more complex. In mammalian somatic cells, RNAi is implicated in endonucleolytic cleavage mediated by artificially delivered small interfering RNAs (siRNAs) as well as in translation repression mediated by microRNAs (miRNAs). Because siRNAs and miRNAs recognize viral mRNAs, RNAi inherently limits virus production and participates in antiviral defense. However, several observations made in the cases of hepatitis C virus and retroviruses (including the human immunodeficiency virus and the primate foamy virus) bring evidence that this relationship is much more complex and that certain components of the RNAi effector complex [called the RNA-induced silencing complex (RISC)], such as AGO2, are also required for viral replication. Here, we summarize recent discoveries that have revealed this dual implication in virus biology. We further discuss their potential implications for the functions of RNAi-related proteins, with special emphasis on retrotransposition and genome stability.

Physics Detector Simulation Facility (PDSF) architecture/utilization

International Nuclear Information System (INIS)

Scipioni, B.

1993-05-01

The current systems architecture for the SSCL's Physics Detector Simulation Facility (PDSF) is presented. Systems analysis data is presented and discussed. In particular, these data disclose the effectiveness of utilization of the facility for meeting the needs of physics computing, especially as concerns parallel architecture and processing. Detailed design plans for the highly networked, symmetric, parallel, UNIX workstation-based facility are given and discussed in light of the design philosophy. Included are network, CPU, disk, router, concentrator, tape, user and job capacities and throughput

Graphics-Printing Program For The HP Paintjet Printer

Science.gov (United States)

Atkins, Victor R.

1993-01-01

IMPRINT utility computer program developed to print graphics specified in raster files by use of Hewlett-Packard Paintjet(TM) color printer. Reads bit-mapped images from files on UNIX-based graphics workstation and prints out three different types of images: wire-frame images, solid-color images, and gray-scale images. Wire-frame images are in continuous tone or, in case of low resolution, in random gray scale. In case of color images, IMPRINT also prints by use of default palette of solid colors. Written in C language.

Next Genertation BioPhotonics Workstation

DEFF Research Database (Denmark)

Bañas, Andrew Rafael; Palima, Darwin; Tauro, Sandeep

We will outline the specs of our Biophotonics Workstation that can generate up to 100 reconfigurable laser-traps making 3D real-time optical manipulation of advanced structures, cells or tiny particles possible with the use of joysticks or gaming devices. Optically actuated nanoneedles may...... be functionalized or directly used to perforate targeted cells at specific locations or force the complete separation of dividing cells, among other functions that can be very useful for microbiologists or biomedical researchers....

Assessment of a cooperative workstation.

OpenAIRE

Beuscart, R. J.; Molenda, S.; Souf, N.; Foucher, C.; Beuscart-Zephir, M. C.

1996-01-01

Groupware and new Information Technologies have now made it possible for people in different places to work together in synchronous cooperation. Very often, designers of this new type of software are not provided with a model of the common workspace, which is prejudicial to software development and its acceptance by potential users. The authors take the example of a task of medical co-diagnosis, using a multi-media communication workstation. Synchronous cooperative work is made possible by us...

Reliability and validity of the Spanish version of the 10-item Connor-Davidson Resilience Scale (10-item CD-RISC in young adults

Directory of Open Access Journals (Sweden)

García-Campayo Javier

2011-08-01

Full Text Available Abstract Background The 10-item Connor-Davidson Resilience Scale (10-item CD-RISC is an instrument for measuring resilience that has shown good psychometric properties in its original version in English. The aim of this study was to evaluate the validity and reliability of the Spanish version of the 10-item CD-RISC in young adults and to verify whether it is structured in a single dimension as in the original English version. Findings Cross-sectional observational study including 681 university students ranging in age from 18 to 30 years. The number of latent factors in the 10 items of the scale was analyzed by exploratory factor analysis. Confirmatory factor analysis was used to verify whether a single factor underlies the 10 items of the scale as in the original version in English. The convergent validity was analyzed by testing whether the mean of the scores of the mental component of SF-12 (MCS and the quality of sleep as measured with the Pittsburgh Sleep Index (PSQI were higher in subjects with better levels of resilience. The internal consistency of the 10-item CD-RISC was estimated using the Cronbach α test and test-retest reliability was estimated with the intraclass correlation coefficient. The Cronbach α coefficient was 0.85 and the test-retest intraclass correlation coefficient was 0.71. The mean MCS score and the level of quality of sleep in both men and women were significantly worse in subjects with lower resilience scores. Conclusions The Spanish version of the 10-item CD-RISC showed good psychometric properties in young adults and thus can be used as a reliable and valid instrument for measuring resilience. Our study confirmed that a single factor underlies the resilience construct, as was the case of the original scale in English.

Viewport: An object-oriented approach to integrate workstation software for tile and stack mode display

OpenAIRE

Ghosh, Srinka; Andriole, Katherine P.; Avrin, David E.

1997-01-01

Diagnostic workstation design has migrated towards display presentation in one of two modes: tiled images or stacked images. It is our impression that the workstation setup or configuration in each of these two modes is rather distinct. We sought to establish a commonality to simplify software design, and to enable a single descriptor method to facilitate folder manager development of “hanging” protocols. All current workstation designs use a combination of “off-screen” and “on-screen” memory...

Applying human factors to the design of control centre and workstation of a nuclear reactor

Energy Technology Data Exchange (ETDEWEB)

Santos, Isaac J.A. Luquetti dos; Carvalho, Paulo V.R.; Goncalves, Gabriel de L., E-mail: luquetti@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Souza, Tamara D.M.F.; Falcao, Mariana A. [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil). Dept. de Desenho Industrial

2013-07-01

Human factors is a body of scientific factors about human characteristics, covering biomedical, psychological and psychosocial considerations, including principles and applications in the personnel selection areas, training, job performance aid tools and human performance evaluation. Control Centre is a combination of control rooms, control suites and local control stations which are functionally related and all on the same site. Digital control room includes an arrangement of systems, equipment such as computers and communication terminals and workstations at which control and monitoring functions are conducted by operators. Inadequate integration between control room and operators reduces safety, increases the operation complexity, complicates operator training and increases the likelihood of human errors occurrence. The objective of this paper is to present a specific approach for the conceptual and basic design of the control centre and workstation of a nuclear reactor used to produce radioisotope. The approach is based on human factors standards, guidelines and the participation of a multidisciplinary team in the conceptual and basic phases of the design. Using the information gathered from standards and from the multidisciplinary team, an initial sketch 3D of the control centre and workstation are being developed. (author)

Applying human factors to the design of control centre and workstation of a nuclear reactor

International Nuclear Information System (INIS)

Santos, Isaac J.A. Luquetti dos; Carvalho, Paulo V.R.; Goncalves, Gabriel de L.; Souza, Tamara D.M.F.; Falcao, Mariana A.

2013-01-01

Human factors is a body of scientific factors about human characteristics, covering biomedical, psychological and psychosocial considerations, including principles and applications in the personnel selection areas, training, job performance aid tools and human performance evaluation. Control Centre is a combination of control rooms, control suites and local control stations which are functionally related and all on the same site. Digital control room includes an arrangement of systems, equipment such as computers and communication terminals and workstations at which control and monitoring functions are conducted by operators. Inadequate integration between control room and operators reduces safety, increases the operation complexity, complicates operator training and increases the likelihood of human errors occurrence. The objective of this paper is to present a specific approach for the conceptual and basic design of the control centre and workstation of a nuclear reactor used to produce radioisotope. The approach is based on human factors standards, guidelines and the participation of a multidisciplinary team in the conceptual and basic phases of the design. Using the information gathered from standards and from the multidisciplinary team, an initial sketch 3D of the control centre and workstation are being developed. (author)

CALIPSO: an interactive image analysis software package for desktop PACS workstations

Science.gov (United States)

Ratib, Osman M.; Huang, H. K.

1990-07-01

The purpose of this project is to develop a low cost workstation for quantitative analysis of multimodality images using a Macintosh II personal computer. In the current configuration the Macintosh operates as a stand alone workstation where images are imported either from a central PACS server through a standard Ethernet network or recorded through video digitizer board. The CALIPSO software developed contains a large variety ofbasic image display and manipulation tools. We focused our effort however on the design and implementation ofquantitative analysis methods that can be applied to images from different imaging modalities. Analysis modules currently implemented include geometric and densitometric volumes and ejection fraction calculation from radionuclide and cine-angiograms Fourier analysis ofcardiac wall motion vascular stenosis measurement color coded parametric display of regional flow distribution from dynamic coronary angiograms automatic analysis ofmyocardial distribution ofradiolabelled tracers from tomoscintigraphic images. Several of these analysis tools were selected because they use similar color coded andparametric display methods to communicate quantitative data extracted from the images. 1. Rationale and objectives of the project Developments of Picture Archiving and Communication Systems (PACS) in clinical environment allow physicians and radiologists to assess radiographic images directly through imaging workstations (''). This convenient access to the images is often limited by the number of workstations available due in part to their high cost. There is also an increasing need for quantitative analysis ofthe images. During thepast decade

An open architecture for medical image workstation

Science.gov (United States)

Liang, Liang; Hu, Zhiqiang; Wang, Xiangyun

2005-04-01

Dealing with the difficulties of integrating various medical image viewing and processing technologies with a variety of clinical and departmental information systems and, in the meantime, overcoming the performance constraints in transferring and processing large-scale and ever-increasing image data in healthcare enterprise, we design and implement a flexible, usable and high-performance architecture for medical image workstations. This architecture is not developed for radiology only, but for any workstations in any application environments that may need medical image retrieving, viewing, and post-processing. This architecture contains an infrastructure named Memory PACS and different kinds of image applications built on it. The Memory PACS is in charge of image data caching, pre-fetching and management. It provides image applications with a high speed image data access and a very reliable DICOM network I/O. In dealing with the image applications, we use dynamic component technology to separate the performance-constrained modules from the flexibility-constrained modules so that different image viewing or processing technologies can be developed and maintained independently. We also develop a weakly coupled collaboration service, through which these image applications can communicate with each other or with third party applications. We applied this architecture in developing our product line and it works well. In our clinical sites, this architecture is applied not only in Radiology Department, but also in Ultrasonic, Surgery, Clinics, and Consultation Center. Giving that each concerned department has its particular requirements and business routines along with the facts that they all have different image processing technologies and image display devices, our workstations are still able to maintain high performance and high usability.

Computer-aided diagnosis workstation and data base system for chest diagnosis based on multihelical CT images

International Nuclear Information System (INIS)

Satoh, H.; Niki, N.; Eguchi, K.; Masuda, H.; Machida, S.; Moriyama, N.

2006-01-01

We have provided diagnostic assistance methods to medical screening specialists by developing a lung cancer screening algorithm that automatically detects suspected lung cancers in helical CT images and a coronary artery calcification screening algorithm that automatically detects suspected coronary artery calcification. We also have developed electronic medical recording system and prototype internet system for the community health in two or more regions by using the Virtual Private Network router, Biometric fingerprint authentication system and Biometric face authentication system for safety of medical information. The results of this study indicate that our computer-aided diagnosis workstation and network system can increase diagnostic speed, diagnostic accuracy and safety of medical information. (author)

Control and stimulation tools (cat) for the PC modelers

International Nuclear Information System (INIS)

Chan, K.S.; Lea, K.C.

1990-01-01

For the last couple of years, the personal computer technology has received a steady stream of improvement in CPU processing power, fast floating coprocessor, super graphics to a very large and fast hard drive. Since Intel began shipping its 80386 version of CPU, it became practical to develop or execute a substantial amount of power plant software on a personal computer. With the introduction of the RISC type personal workstation, complete simulators based on these new generation of computers will soon become a reality. As of today, although almost anybody can afford a personal computer, simulation supporting software is still rare or non-existent at all. The CAST has been designed to support those users who want to develop or debug large power plant simulation programs on a personal computer or workstation. Another separate paper will also be presented to demonstrate the real world development and debugging tools offered by CAST

Visualization of unsteady computational fluid dynamics

Science.gov (United States)

Haimes, Robert

1994-11-01

A brief summary of the computer environment used for calculating three dimensional unsteady Computational Fluid Dynamic (CFD) results is presented. This environment requires a super computer as well as massively parallel processors (MPP's) and clusters of workstations acting as a single MPP (by concurrently working on the same task) provide the required computational bandwidth for CFD calculations of transient problems. The cluster of reduced instruction set computers (RISC) is a recent advent based on the low cost and high performance that workstation vendors provide. The cluster, with the proper software can act as a multiple instruction/multiple data (MIMD) machine. A new set of software tools is being designed specifically to address visualizing 3D unsteady CFD results in these environments. Three user's manuals for the parallel version of Visual3, pV3, revision 1.00 make up the bulk of this report.

Mikado: A graphic program

Science.gov (United States)

Secretan, Y.

A discussion of the modular program Mikado is presented. Mikado was developed with the goal of creating a flexible graphic tool to display and help analyze the results of finite element fluid flow computations. Mikado works on unstructured meshes, with elements of mixed geometric type, but also offers the possibility of using structured meshes. The program can be operated by both menu and mouse (interactive), or by command file (batch). Mikado is written in FORTRAN, except for a few system dependent subroutines which are in C. It runs presently on Silicon Graphics' workstations and could be easily ported to the IBM-RISC System/6000 family of workstations.

GOCE user toolbox and tutorial

DEFF Research Database (Denmark)

Knudsen, Per; Benveniste, Jerome

2011-01-01

consists of a series of advanced computer routines that carry out the required computations. It may be used on Windows PCs, UNIX/Linux Workstations, and Mac. The toolbox is supported by The GUT Algorithm Description and User Guide and The GUT Install Guide. A set of a-priori data and models are made...

Validity and reliability of the Spanish version of the 10-item CD-RISC in patients with fibromyalgia

Science.gov (United States)

2014-01-01

Background No resilience scale has been validated in Spanish patients with fibromyalgia. The aim of this study was to evaluate the validity and reliability of the 10-item CD-RISC in a sample of Spanish patients with fibromyalgia. Methods Design: Observational prospective multicenter study. Sample: Patients with diagnoses of fibromyalgia recruited from primary care settings (N = 208). Instruments: In addition to sociodemographic data, the following questionnaires were administered: Pain Visual Analogue Scale (PVAS), the 10-item Connor-Davidson Resilience scale (10-item CD-RISC), the Fibromyalgia Impact Questionnaire (FIQ), the Hospital Anxiety and Depression Scale (HADS), the Pain Catastrophizing Scale (PCS), the Chronic Pain Acceptance Questionnaire (CPAQ), and the Mindful Attention Awareness Scale (MAAS). Results Regarding construct validity, the factor solution in the Principal Component Analysis (PCA) was considered adequate, so the KMO test had a value of 0.91, and the Barlett’s test of sphericity was significant (χ2 = 852.8; gl = 45; p fibromyalgia, acceptable psychometric properties, with a high level of reliability and validity. PMID:24484847

Treadmill workstations: the effects of walking while working on physical activity and work performance.

Directory of Open Access Journals (Sweden)

Avner Ben-Ner

Full Text Available We conducted a 12-month-long experiment in a financial services company to study how the availability of treadmill workstations affects employees' physical activity and work performance. We enlisted sedentary volunteers, half of whom received treadmill workstations during the first two months of the study and the rest in the seventh month of the study. Participants could operate the treadmills at speeds of 0-2 mph and could use a standard chair-desk arrangement at will. (a Weekly online performance surveys were administered to participants and their supervisors, as well as to all other sedentary employees and their supervisors. Using within-person statistical analyses, we find that overall work performance, quality and quantity of performance, and interactions with coworkers improved as a result of adoption of treadmill workstations. (b Participants were outfitted with accelerometers at the start of the study. We find that daily total physical activity increased as a result of the adoption of treadmill workstations.

Treadmill workstations: the effects of walking while working on physical activity and work performance.

Science.gov (United States)

Ben-Ner, Avner; Hamann, Darla J; Koepp, Gabriel; Manohar, Chimnay U; Levine, James

2014-01-01

We conducted a 12-month-long experiment in a financial services company to study how the availability of treadmill workstations affects employees' physical activity and work performance. We enlisted sedentary volunteers, half of whom received treadmill workstations during the first two months of the study and the rest in the seventh month of the study. Participants could operate the treadmills at speeds of 0-2 mph and could use a standard chair-desk arrangement at will. (a) Weekly online performance surveys were administered to participants and their supervisors, as well as to all other sedentary employees and their supervisors. Using within-person statistical analyses, we find that overall work performance, quality and quantity of performance, and interactions with coworkers improved as a result of adoption of treadmill workstations. (b) Participants were outfitted with accelerometers at the start of the study. We find that daily total physical activity increased as a result of the adoption of treadmill workstations.

Instructor station of full scope simulator for Qinshan 300 MW Nuclear Power Unit

International Nuclear Information System (INIS)

Wu Fanghui

1996-01-01

The instructor station of Full Scope Simulator for Qinshan 300 MW Nuclear Power Unit is based on SGI graphic workstation. The operation system is real time UNIX, and the development of man-machine interface, mainly depends on standard X window system, special for X TOOLKITS and MOTIF. The instructor station has been designed to increase training effectiveness and provide the most flexible environment possible to enhance its usefulness. Based on experiences in the development of the instructor station, many new features have been added including I/O panel diagrams, simulation diagrams, graphic operation of malfunction, remote function and I/O overrides etc

Study of risc factors affecting the number of mental disorders and nervous system diseases for people who participated in liquidation of consequences of ChNPP accident

International Nuclear Information System (INIS)

Ivanov, V.K.; Chekin, S.Yu.; Mikhal'skij, A.I.; Petrovskij, A.M.

1992-01-01

Interrelation of disease incidence for liquidators and factors affecting it has been studied. The diseases (mental disorders and nervous system diseases) have been taken into account provided more than 10% of people have suffered of the above diseases. Date of getting into the accident zone; duration of work within the zone; the radiation dose accumulated were considered to be risc factors. Getting into the accident zone and duration of work within the zone of accident have been though to be the main risc factors. 3 figs.; 2 tabs

Physics and detector simulation facility Type O workstation specifications

International Nuclear Information System (INIS)

Chartrand, G.; Cormell, L.R.; Hahn, R.; Jacobson, D.; Johnstad, H.; Leibold, P.; Marquez, M.; Ramsey, B.; Roberts, L.; Scipioni, B.; Yost, G.P.

1990-11-01

This document specifies the requirements for the front-end network of workstations of a distributed computing facility. This facility will be needed to perform the physics and detector simulations for the design of Superconducting Super Collider (SSC) detectors, and other computations in support of physics and detector needs. A detailed description of the computer simulation facility is given in the overall system specification document. This document provides revised subsystem specifications for the network of monitor-less Type 0 workstations. The requirements specified in this document supersede the requirements given. In Section 2 a brief functional description of the facility and its use are provided. The list of detailed specifications (vendor requirements) is given in Section 3 and the qualifying requirements (benchmarks) are described in Section 4

Transmissió vertical del virus de l'hepatitis C. Factors de risc, història natural dels nens infectats i evolució a llarg termini

OpenAIRE

Viñolas Tolosa, Maria

2016-01-01

Introducció: La TV del VHC succeeix en el 5-15% dels casos i depèn de factors de risc materns, obstètrics i neonatals. Fins el moment existeix poca informació sobre l’evolució dels nens infectats més enllà dels 2 o 3 primers anys de vida. L’objectiu del present estudi es determinar la taxa de TV, els factors de risc i l’evolució a llarg termini dels nens infectats. Pacients i mètodes: Estudi prospectiu de cohorts de 120 gestants infectades per VHC i els seus fills nascuts a l’Hospital del ...

Stand by Me: Qualitative Insights into the Ease of Use of Adjustable Workstations.

Science.gov (United States)

Leavy, Justine; Jancey, Jonine

2016-01-01

Office workers sit for more than 80% of the work day making them an important target for work site health promotion interventions to break up prolonged sitting time. Adjustable workstations are one strategy used to reduce prolonged sitting time. This study provides both an employees' and employers' perspective into the advantages, disadvantages, practicality and convenience of adjustable workstations and how movement in the office can be further supported by organisations. This qualitative study was part of the Uprising pilot study. Employees were from the intervention arm of a two group (intervention n = 18 and control n = 18) study. Employers were the immediate line-manager of the employee. Data were collected via employee focus groups (n = 17) and employer individual interviews (n = 12). The majority of participants were female (n = 18), had healthy weight, and had a post-graduate qualification. All focus group discussions and interviews were recorded, transcribed verbatim and the data coded according to the content. Qualitative content analysis was conducted. Employee data identified four concepts: enhanced general wellbeing; workability and practicality; disadvantages of the retro-fit; and triggers to stand. Most employees (n = 12) reported enhanced general well-being, workability and practicality included less email exchange and positive interaction (n = 5), while the instability of the keyboard a commonly cited disadvantage. Triggers to stand included time and task based prompts. Employer data concepts included: general health and wellbeing; work engagement; flexibility; employee morale; and injury prevention. Over half of the employers (n = 7) emphasised back care and occupational health considerations as important, as well as increased level of staff engagement and strategies to break up prolonged periods of sitting. The focus groups highlight the perceived general health benefits from this short intervention, including opportunity to sit less and interact

Stand by Me: Qualitative Insights into the Ease of Use of Adjustable Workstations

Directory of Open Access Journals (Sweden)

Jonine Jancey

2016-08-01

Full Text Available Background: Office workers sit for more than 80% of the work day making them an important target for work site health promotion interventions to break up prolonged sitting time. Adjustable workstations are one strategy used to reduce prolonged sitting time. This study provides both an employees’ and employers’ perspective into the advantages, disadvantages, practicality and convenience of adjustable workstations and how movement in the office can be further supported by organisations. This qualitative study was part of the Uprising pilot study. Employees were from the intervention arm of a two group (intervention n = 18 and control n = 18 study. Employers were the immediate line-manager of the employee. Data were collected via employee focus groups (n = 17 and employer individual interviews (n = 12. The majority of participants were female (n = 18, had healthy weight, and had a post-graduate qualification. All focus group discussions and interviews were recorded, transcribed verbatim and the data coded according to the content. Qualitative content analysis was conducted. Results: Employee data identified four concepts: enhanced general wellbeing; workability and practicality; disadvantages of the retro-fit; and triggers to stand. Most employees (n = 12 reported enhanced general well-being, workability and practicality included less email exchange and positive interaction (n = 5, while the instability of the keyboard a commonly cited disadvantage. Triggers to stand included time and task based prompts. Employer data concepts included: general health and wellbeing; work engagement; flexibility; employee morale; and injury prevention. Over half of the employers (n = 7 emphasised back care and occupational health considerations as important, as well as increased level of staff engagement and strategies to break up prolonged periods of sitting. Discussion: The focus groups highlight the perceived general health benefits from this short

BioPhotonics Workstation: a university tech transfer challenge

DEFF Research Database (Denmark)

Glückstad, Jesper; Bañas, Andrew Rafael; Tauro, Sandeep

2011-01-01

Conventional optical trapping or tweezing is often limited in the achievable trapping range because of high numerical aperture and imaging requirements. To circumvent this, we are developing a next generation BioPhotonics Workstation platform that supports extension modules through a long working...

Ergonomics in the computer workstation | Karoney | East African ...

African Journals Online (AJOL)

Background: Awareness of effects of long term use of computer and application of ergonomics in the computer workstation is important for preventing musculoskeletal disorders, eyestrain and psychosocial effects. Objectives: To determine the awareness of ºphysical and psychological effects of prolonged computer usage ...

Development of nuclear reaction data retrieval system on Meme media

International Nuclear Information System (INIS)

Ohbayasi, Yosihide; Masui, Hiroshi; Aoyama, Shigeyoshi; Kato, Kiyoshi; Chiba, Masaki

2000-01-01

A newly designed retrieval system of charged particle nuclear reaction data is developed on Meme media architecture. We designed the network-based (client-server) retrieval system. The server system is constructed on a UNIX workstation with a relational database, and the client system is constructed on Microsoft Windows PC using an IntelligentPad software package. The IntelligentPad is currently available as developing Meme media. We will develop the system to realize effective utilization of nuclear reaction data: I. 'Re-production, Re-edit, Re-use', II. 'Circulation, Coordination and Evolution', III. 'Knowledge discovery'. (author)

An implementation of SAS reg-sign in an environmental information system

International Nuclear Information System (INIS)

James, T.; Zygmunt, B.C.

1994-01-01

This paper describes a software environmental database information system that uses SAS to process data and ORACLE reg-sign as the relational database management system (RDBMS). The hardware includes a network of UNIX-based servers and workstations. The relational database consists of large tables containing envionmental measurement data, as well as other smaller tables with reference, metadata and internal administrative information. The data come in a variety of formats and must be converted to conform to the system's standards. SAS/ACCESS reg-sign and PROC SQL are used extensively in the data processing

Parallelization of ITOUGH2 using PVM

International Nuclear Information System (INIS)

Finsterle, Stefan

1998-01-01

ITOUGH2 inversions are computationally intensive because the forward problem must be solved many times to evaluate the objective function for different parameter combinations or to numerically calculate sensitivity coefficients. Most of these forward runs are independent from each other and can therefore be performed in parallel. Message passing based on the Parallel Virtual Machine (PVM) system has been implemented into ITOUGH2 to enable parallel processing of ITOUGH2 jobs on a heterogeneous network of Unix workstations. This report describes the PVM system and its implementation into ITOUGH2. Instructions are given for installing PVM, compiling ITOUGH2-PVM for use on a workstation cluster, the preparation of an 1.TOUGH2 input file under PVM, and the execution of an ITOUGH2-PVM application. Examples are discussed, demonstrating the use of ITOUGH2-PVM

Parallelization of MCNP4 code by using simple FORTRAN algorithms

International Nuclear Information System (INIS)

Yazid, P.I.; Takano, Makoto; Masukawa, Fumihiro; Naito, Yoshitaka.

1993-12-01

Simple FORTRAN algorithms, that rely only on open, close, read and write statements, together with disk files and some UNIX commands have been applied to parallelization of MCNP4. The code, named MCNPNFS, maintains almost all capabilities of MCNP4 in solving shielding problems. It is able to perform parallel computing on a set of any UNIX workstations connected by a network, regardless of the heterogeneity in hardware system, provided that all processors produce a binary file in the same format. Further, it is confirmed that MCNPNFS can be executed also on Monte-4 vector-parallel computer. MCNPNFS has been tested intensively by executing 5 photon-neutron benchmark problems, a spent fuel cask problem and 17 sample problems included in the original code package of MCNP4. Three different workstations, connected by a network, have been used to execute MCNPNFS in parallel. By measuring CPU time, the parallel efficiency is determined to be 58% to 99% and 86% in average. On Monte-4, MCNPNFS has been executed using 4 processors concurrently and has achieved the parallel efficiency of 79% in average. (author)

Using RGB-D sensors and evolutionary algorithms for the optimization of workstation layouts.

Science.gov (United States)

Diego-Mas, Jose Antonio; Poveda-Bautista, Rocio; Garzon-Leal, Diana

2017-11-01

RGB-D sensors can collect postural data in an automatized way. However, the application of these devices in real work environments requires overcoming problems such as lack of accuracy or body parts' occlusion. This work presents the use of RGB-D sensors and genetic algorithms for the optimization of workstation layouts. RGB-D sensors are used to capture workers' movements when they reach objects on workbenches. Collected data are then used to optimize workstation layout by means of genetic algorithms considering multiple ergonomic criteria. Results show that typical drawbacks of using RGB-D sensors for body tracking are not a problem for this application, and that the combination with intelligent algorithms can automatize the layout design process. The procedure described can be used to automatically suggest new layouts when workers or processes of production change, to adapt layouts to specific workers based on their ways to do the tasks, or to obtain layouts simultaneously optimized for several production processes. Copyright © 2017 Elsevier Ltd. All rights reserved.

The replacement of touch-terminal consoles of the CERN antiproton accumulator complex (AAC) by office PC's as well as X-windows based workstations

International Nuclear Information System (INIS)

Chohan, V.; Deloose, I.; Shering, G.

1992-01-01

With aging hardware and expensive maintenance and replacement possibilities, it was decided to upgrade the AAC touch terminal consoles with modern hardware. With significant amount of operational application software developed with touch terminals over 10 years, the philosophy adopted was to attempt a total emulation of these console functions of touch actions, graphics display as well as simple keyboard terminal entry onto the front-end computer controlling the AAC. The PC based emulation by mouse and multiple windows under MS-DOS and later, under the Windows 3 environment was realized relatively quickly; the next stage was therefore to do the same on the Unix platform using software based on X-windows. The communications channel was established using the TCP/IP socket library. This paper reviews this work up to the operational implementation for routine control room usage for both these solutions. (author)

Experience using EPICS on PC platforms

International Nuclear Information System (INIS)

Hill, J.O.; Kasemire, K.U.

1997-03-01

The Experimental Physics and Industrial Control System (EPICS) has been widely adopted in the accelerator community. Although EPICS is available on many platforms, the majority of implementations have used UNIX workstations as clients, and VME- or VXI-based processors for distributed input output controllers. Recently, a significant portion of EPICS has been ported to personal computer (PC) hardware platforms running Microsoft's operating systems, and also Wind River System's real time vxWorks operating system. This development should significantly reduce the cost of deploying EPICS systems, and the prospect of using EPICS together with the many high quality commercial components available for PC platforms is also encouraging. A hybrid system using both PC and traditional platforms is currently being implemented at LANL for LEDA, the low energy demonstration accelerator under construction as part of the Accelerator Production of Tritium (APT) project. To illustrate these developments the authors compare their recent experience deploying a PC-based EPICS system with experience deploying similar systems based on traditional (UNIX-hosted) EPICS hardware and software platforms

Implementation of a high-resolution workstation for primary diagnosis of projection radiography images

Science.gov (United States)

Good, Walter F.; Herron, John M.; Maitz, Glenn S.; Gur, David; Miller, Stephen L.; Straub, William H.; Fuhrman, Carl R.

1990-08-01

We designed and implemented a high-resolution video workstation as the central hardware component in a comprehensive multi-project program comparing the use of digital and film modalities. The workstation utilizes a 1.8 GByte real-time disk (RCI) capable of storing 400 full-resolution images and two Tektronix (GMA251) display controllers with 19" monitors (GMA2O2). The display is configured in a portrait format with a resolution of 1536 x 2048 x 8 bit, and operates at 75 Hz in a noninterlaced mode. Transmission of data through a 12 to 8 bit lookup table into the display controllers occurs at 20 MBytes/second (.35 seconds per image). The workstation allows easy use of brightness (level) and contrast (window) to be manipulated with a trackball, and various processing options can be selected using push buttons. Display of any of the 400 images is also performed at 20MBytes/sec (.35 sec/image). A separate text display provides for the automatic display of patient history data and for a scoring form through which readers can interact with the system by means of a computer mouse. In addition, the workstation provides for the randomization of cases and for the immediate entry of diagnostic responses into a master database. Over the past year this workstation has been used for over 10,000 readings in diagnostic studies related to 1) image resolution; 2) film vs. soft display; 3) incorporation of patient history data into the reading process; and 4) usefulness of image processing.

Users Guide to VSMOKE-GIS for Workstations

Science.gov (United States)

Mary F. Harms; Leonidas G. Lavdas

1997-01-01

VSMOKE-GIS was developed to help prescribed burners in the national forests of the Southeastern United States visualize smoke dispersion and to plan prescribed burns. Developed for use on workstations, this decision-support system consists of a graphical user interface, written in Arc/Info Arc Macro Language, and is linked to a FORTRAN computer program. VSMOKE-GIS...

Post-deployment usability evaluation of a radiology workstation

NARCIS (Netherlands)

Jorritsma, Wiard; Cnossen, Fokie; Dierckx, Rudi; Oudkerk, Matthijs; van Ooijen, Peter

2015-01-01

Objective To evaluate the usability of a radiology workstation after deployment in a hospital. Significance In radiology, it is difficult to perform valid pre-deployment usability evaluations due to the heterogeneity of the user group, the complexity of the radiological workflow, and the complexity

Interpretation of digital breast tomosynthesis: preliminary study on comparison with picture archiving and communication system (PACS) and dedicated workstation.

Science.gov (United States)

Kim, Young Seon; Chang, Jung Min; Yi, Ann; Shin, Sung Ui; Lee, Myung Eun; Kim, Won Hwa; Cho, Nariya; Moon, Woo Kyung

2017-08-01

To compare the diagnostic accuracy and efficiency in the interpretation of digital breast tomosynthesis (DBT) images using a picture archiving and communication system (PACS) and a dedicated workstation. 97 DBT images obtained for screening or diagnostic purposes were stored in both a workstation and a PACS and evaluated in combination with digital mammography by three independent radiologists retrospectively. Breast Imaging-Reporting and Data System final assessments and likelihood of malignancy (%) were assigned and the interpretation time when using the workstation and PACS was recorded. Receiver operating characteristic curve analysis, sensitivities and specificities were compared with histopathological examination and follow-up data as a reference standard. Area under the receiver operating characteristic curve values for cancer detection (0.839 vs 0.815, p = 0.6375) and sensitivity (81.8% vs 75.8%, p = 0.2188) showed no statistically significant differences between the workstation and PACS. However, specificity was significantly higher when analysing on the workstation than when using PACS (83.7% vs 76.9%, p = 0.009). When evaluating DBT images using PACS, only one case was deemed necessary to be reanalysed using the workstation. The mean time to interpret DBT images on PACS (1.68 min/case) was significantly longer than that to interpret on the workstation (1.35 min/case) (p < 0.0001). Interpretation of DBT images using PACS showed comparable diagnostic performance to a dedicated workstation, even though it required a longer reading time. Advances in knowledge: Interpretation of DBT images using PACS is an alternative to evaluate the images when a dedicated workstation is not available.

A real-time monitoring/emergency response workstation using a 3-D numerical model initialized with SODAR

International Nuclear Information System (INIS)

Lawver, B.S.; Sullivan, T.J.; Baskett, R.L.

1993-01-01

Many workstation based emergency response dispersion modeling systems provide simple Gaussian models driven by single meteorological tower inputs to estimate the downwind consequences from accidental spills or stack releases. Complex meteorological or terrain settings demand more sophisticated resolution of the three-dimensional structure of the atmosphere to reliably calculate plume dispersion. Mountain valleys and sea breeze flows are two common examples of such settings. To address these complexities, we have implemented the three-dimensional-diagnostic MATHEW mass-adjusted wind field and ADPIC particle-in-cell dispersion models on a workstation for use in real-time emergency response modeling. Both MATHEW and ADPIC have shown their utility in a variety of complex settings over the last 15 years within the Department of Energy's Atmospheric Release Advisory Capability project

Graphics metafile interface to ARAC emergency response models for remote workstation study

International Nuclear Information System (INIS)

Lawver, B.S.

1985-01-01

The Department of Energy's Atmospheric Response Advisory Capability models are executed on computers at a central computer center with the output distributed to accident advisors in the field. The output of these atmospheric diffusion models are generated as contoured isopleths of concentrations. When these isopleths are overlayed with local geography, they become a useful tool to the accident site advisor. ARAC has developed a workstation that is located at potential accident sites. The workstation allows the accident advisor to view color plots of the model results, scale those plots and print black and white hardcopy of the model results. The graphics metafile, also known as Virtual Device Metafile (VDM) allows the models to generate a single device independent output file that is partitioned into geography, isoopleths and labeling information. The metafile is a very compact data storage technique that is output device independent. The metafile frees the model from either generating output for all known graphic devices or requiring the model to be rerun for additional graphic devices. With the partitioned metafile ARAC can transmit to the remote workstation the isopleths and labeling for each model. The geography database may not change and can be transmitted only when needed. This paper describes the important features of the remote workstation and how these features are supported by the device independent graphics metafile

Ergonomics standards and guidelines for computer workstation design and the impact on users' health - a review.

Science.gov (United States)

Woo, E H C; White, P; Lai, C W K

2016-03-01

This paper presents an overview of global ergonomics standards and guidelines for design of computer workstations, with particular focus on their inconsistency and associated health risk impact. Overall, considerable disagreements were found in the design specifications of computer workstations globally, particularly in relation to the results from previous ergonomics research and the outcomes from current ergonomics standards and guidelines. To cope with the rapid advancement in computer technology, this article provides justifications and suggestions for modifications in the current ergonomics standards and guidelines for the design of computer workstations. Practitioner Summary: A research gap exists in ergonomics standards and guidelines for computer workstations. We explore the validity and generalisability of ergonomics recommendations by comparing previous ergonomics research through to recommendations and outcomes from current ergonomics standards and guidelines.

Competency-Based Teaching in Radiology - Implementation and Evaluation of Interactive Workstation-Based Learning to Apply NKLM-Based Content.

Science.gov (United States)

Koestner, Wolfgang; Otten, Wiebke; Kaireit, Till; Wacker, Frank K; Dettmer, Sabine

2017-11-01

.. · Students report improved understanding of imaging anatomy and radiological findings.. · Interactive case presentation with a DICOM viewer fosters competency-based learning.. Citation Format · Koestner W, Otten W, Kaireit T et al. Competency-Based Teaching in Radiology - Implementation and Evaluation of Interactive Workstation-Based Learning to Apply NKLM-Based Content. Fortschr Röntgenstr 2017; 189: 1076 - 1085. © Georg Thieme Verlag KG Stuttgart · New York.

A real-time monitoring/emergency response modeling workstation for a tritium facility

International Nuclear Information System (INIS)

Lawver, B.S.; Sims, J.M.; Baskett, R.L.

1993-07-01

At Lawrence Livermore National Laboratory (LLNL) we developed a real-time system to monitor two stacks on our tritium handling facility. The monitors transmit the stack data to a workstation which computes a 3D numerical model of atmospheric dispersion. The workstation also collects surface and upper air data from meteorological towers and a sodar. The complex meteorological and terrain setting in the Livermore Valley demands more sophisticated resolution of the three-dimensional structure of the atmosphere to reliably calculate plume dispersion than afforded by Gaussian models. We experience both mountain valley and sea breeze flows. To address these complexities, we have implemented the three-dimensional diagnostic MATHEW mass-adjusted wind field and ADPIC particle-in-cell dispersion models on the workstation for use in real-time emergency response modeling. Both MATHEW and ADPIC have shown their utility in a variety of complex settings over the last 15 years within the Department of Energy's Atmospheric Release Advisory Capability (ARAC[1,2]) project

The advanced software development workstation project

Science.gov (United States)

Fridge, Ernest M., III; Pitman, Charles L.

1991-01-01

The Advanced Software Development Workstation (ASDW) task is researching and developing the technologies required to support Computer Aided Software Engineering (CASE) with the emphasis on those advanced methods, tools, and processes that will be of benefit to support all NASA programs. Immediate goals are to provide research and prototype tools that will increase productivity, in the near term, in projects such as the Software Support Environment (SSE), the Space Station Control Center (SSCC), and the Flight Analysis and Design System (FADS) which will be used to support the Space Shuttle and Space Station Freedom. Goals also include providing technology for development, evolution, maintenance, and operations. The technologies under research and development in the ASDW project are targeted to provide productivity enhancements during the software life cycle phase of enterprise and information system modeling, requirements generation and analysis, system design and coding, and system use and maintenance. On-line user's guides will assist users in operating the developed information system with knowledge base expert assistance.

Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment.

Science.gov (United States)

Kim, Bong Cho; Lee, Hyung Chul; Lee, Je-Jung; Choi, Chang-Min; Kim, Dong-Kwan; Lee, Jae Cheol; Ko, Young-Gyu; Lee, Jae-Seon

2012-11-14

Premature senescence, a key strategy used to suppress carcinogenesis, can be driven by p53/p21 proteins in response to various stresses. Here, we demonstrate that Wig1 plays a critical role in this process through regulation of p21 mRNA stability. Wig1 controls the association of Argonaute2 (Ago2), a central component of the RNA-induced silencing complex (RISC), with target p21 mRNA via binding of the stem-loop structure near the microRNA (miRNA) target site. Depletion of Wig1 prohibited miRNA-mediated p21 mRNA decay and resulted in premature senescence. Wig1 plays an essential role in cell proliferation, as demonstrated in tumour xenografts in mice, and Wig1 and p21 mRNA levels are inversely correlated in human normal and cancer tissues. Together, our data indicate a novel role of Wig1 in RISC target accessibility, which is a key step in RNA-mediated gene silencing. In addition, these findings indicate that fine-tuning of p21 levels by Wig1 is essential for the prevention of cellular senescence.

Criticality codes migration to workstations at the Hanford site

International Nuclear Information System (INIS)

Miller, E.M.

1993-01-01

Westinghouse Hanford Company, Hanford Site Operations contractor, Richland, Washington, currently runs criticality codes on the Cray X-MP EA/232 computer but has recommended that US Department of Energy DOE-Richland replace the Cray with more economical workstations

Workstation Table Engineering Model Design, Development, Fabrication, and Testing

Science.gov (United States)

2012-05-01

This research effort is focused on providing a workstation table design that will reduce the risk of occupant injuries due to secondary impacts and to compartmentalize the occupants to prevent impacts with other objects and/or passengers seated acros...

The effect of a sit-stand workstation intervention on daily sitting, standing and physical activity: protocol for a 12 month workplace randomised control trial.

Science.gov (United States)

Hall, Jennifer; Mansfield, Louise; Kay, Tess; McConnell, Alison K

2015-02-15

A lack of physical activity and excessive sitting can contribute to poor physical health and wellbeing. The high percentage of the UK adult population in employment, and the prolonged sitting associated with desk-based office-work, make these workplaces an appropriate setting for interventions to reduce sedentary behaviour and increase physical activity. This pilot study aims to determine the effect of an office-based sit-stand workstation intervention, compared with usual desk use, on daily sitting, standing and physical activity, and to examine the factors that underlie sitting, standing and physical activity, within and outside, the workplace. A randomised control trial (RCT) comparing the effects of a sit-stand workstation only and a multi-component sit-stand workstation intervention, with usual desk-based working practice (no sit-stand workstation) will be conducted with office workers across two organisations, over a 12 month period (N = 30). The multicomponent intervention will comprise organisational, environmental and individual elements. Objective data will be collected at baseline, and after 2-weeks, 3-months, 6-months and 12-months of the intervention. Objective measures of sitting, standing, and physical activity will be made concurrently (ActivPAL3™ and ActiGraph (GT3X+)). Activity diaries, ethnographic participant observation, and interviews with participants and key organisational personnel will be used to elicit understanding of the influence of organisational culture on sitting, standing and physical activity behaviour in the workplace. This study will be the first long-term sit-stand workstation intervention study utilising an RCT design, and incorporating a comprehensive process evaluation. The study will generate an understanding of the factors that encourage and restrict successful implementation of sit-stand workstation interventions, and will help inform future occupational wellbeing policy and practice. Other strengths include the

The integrated workstation: A common, consistent link between nuclear plant personnel and plant information and computerized resources

International Nuclear Information System (INIS)

Wood, R.T.; Knee, H.E.; Mullens, J.A.; Munro, J.K. Jr.; Swail, B.K.; Tapp, P.A.

1993-01-01

The increasing use of computer technology in the US nuclear power industry has greatly expanded the capability to obtain, analyze, and present data about the plant to station personnel. Data concerning a power plant's design, configuration, operational and maintenance histories, and current status, and the information that can be derived from them, provide the link between the plant and plant staff. It is through this information bridge that operations, maintenance and engineering personnel understand and manage plant performance. However, it is necessary to transform the vast quantity of data available from various computer systems and across communications networks into clear, concise, and coherent information. In addition, it is important to organize this information into a consolidated, structured form within an integrated environment so that various users throughout the plant have ready access at their local station to knowledge necessary for their tasks. Thus, integrated workstations are needed to provide the inquired information and proper software tools, in a manner that can be easily understood and used, to the proper users throughout the plant. An effort is underway at the Oak Ridge National Laboratory to address this need by developing Integrated Workstation functional requirements and implementing a limited-scale prototype demonstration. The integrated Workstation requirements will define a flexible, expandable computer environment that permits a tailored implementation of workstation capabilities and facilitates future upgrades to add enhanced applications. The functionality to be supported by the integrated workstation and inherent capabilities to be provided by the workstation environment win be described. In addition, general technology areas which are to be addressed in the Integrated Workstation functional requirements will be discussed

The driver workstation in commercial vehicles; Ergonomie und Design von Fahrerarbeitsplaetzen in Nutzfahrzeugen

Energy Technology Data Exchange (ETDEWEB)

Kraus, W. [HAW-Hamburg (Germany)

2003-07-01

Nowadays, ergonomics and design are quality factors and indispensable elements of commercial vehicle design and development. Whereas a vehicle's appearance, i.e. its outside design, produces fascination and image, the design of its passenger cell focuses entirely on drivers and their tasks. Today, passenger-cell design and the ergonomics of driver workstations in commercial vehicles are clearly becoming more and more important. This article concentrates above all on defining commercial vehicle drivers, which, within the scope of research projects on coach-driver workstations, has provided new insight into the design of driver workstations. In light of the deficits determined, the research project mainly focused on designing driver workstations which were in line with the latest findings in ergonomics and human engineering. References to the methodology of driver-workstation optimization seems important in this context. The afore-mentioned innovations in the passenger cells of commercial vehicles will be explained and described by means of topical and practical examples. (orig.) [German] Ergonomie und Design sind heute Qualitaetsfaktoren und unverzichtbarer Bestandteil bei der Entwicklung von Nutzfahrzeugen. Erzeugt das Erscheinungsbild, die Aussengestaltung des Fahrzeugs, die Faszination und das Image, so ist die Innengestaltung weitgehend ganz auf die Bedienpersonen und ihre Arbeitsaufgaben bezogen. Die Innenraumgestaltung und die Ergonomie von Fahrerarbeitsplaetzen in Nutzfahrzeugen sind heute in einer Phase der deutlichen Aufwertung zu sehen. Im Beitrag wird besonders auf die Definition der Bedienpersonen fuer Nutzfahrzeuge eingegangen, die im Rahmen des Forschungsprojekts Fahrerarbeitsplatz im Reisebus zu neuen Erkenntnissen bei der Auslegung von Arbeitsplaetzen fuehrte. Gemaess der ermittelten Defizite konzentriert sich die Studie im Kern auf das Gestaltungskonzept des Fahrerarbeitsplatzes nach ergonomischen und arbeitswissenschaftlichen Erkenntnissen

Fast algorithm for the rendering of three-dimensional surfaces

Science.gov (United States)

Pritt, Mark D.

1994-02-01

It is often desirable to draw a detailed and realistic representation of surface data on a computer graphics display. One such representation is a 3D shaded surface. Conventional techniques for rendering shaded surfaces are slow, however, and require substantial computational power. Furthermore, many techniques suffer from aliasing effects, which appear as jagged lines and edges. This paper describes an algorithm for the fast rendering of shaded surfaces without aliasing effects. It is much faster than conventional ray tracing and polygon-based rendering techniques and is suitable for interactive use. On an IBM RISC System/6000TM workstation it renders a 1000 X 1000 surface in about 7 seconds.

GPAW - massively parallel electronic structure calculations with Python-based software

DEFF Research Database (Denmark)

Enkovaara, Jussi; Romero, Nichols A.; Shende, Sameer

2011-01-01

of the productivity enhancing features together with a good numerical performance. We have used this approach in implementing an electronic structure simulation software GPAW using the combination of Python and C programming languages. While the chosen approach works well in standard workstations and Unix...... popular choice. While dynamic, interpreted languages, such as Python, can increase the effciency of programmer, they cannot compete directly with the raw performance of compiled languages. However, by using an interpreted language together with a compiled language, it is possible to have most...... environments, massively parallel supercomputing systems can present some challenges in porting, debugging and profiling the software. In this paper we describe some details of the implementation and discuss the advantages and challenges of the combined Python/C approach. We show that despite the challenges...

RISC-KIT: Resilience-increasing Strategies for Coasts

Directory of Open Access Journals (Sweden)

van Dongeren Ap

2016-01-01

Full Text Available High-impact storm events have demonstrated the vulnerability of coastal zones in Europe and beyond. These impacts are likely to increase due to predicted climate change and ongoing coastal development. In order to reduce impacts, disaster risk reduction (DRR measures need to be taken, which prevent or mitigate the effects of storm events. To drive the DRR agenda, the UNISDR formulated the Sendai Framework for Action, and the EU has issued the Floods Directive. However, neither is specific about the methods to be used to develop actionable DRR measures in the coastal zone. Therefore, there is a need to develop methods, tools and approaches which make it possible to: identify and prioritize the coastal zones which are most at risk through a Coastal Risk Assessment Framework, and to evaluate the effectiveness of DRR options for these coastal areas, using an Early Warning/Decision Support System, which can be used both in the planning and event-phase. This paper gives an overview of the products and results obtained in the FP7-funded project RISC-KIT, which aims to develop and apply a set of tools with which highly-vulnerable coastal areas (so-called “hotspots” can be identified.

Evaluation of total workstation CT interpretation quality: a single-screen pilot study

Science.gov (United States)

Beard, David V.; Perry, John R.; Muller, Keith E.; Misra, Ram B.; Brown, P.; Hemminger, Bradley M.; Johnston, Richard E.; Mauro, J. Matthew; Jaques, P. F.; Schiebler, M.

1991-07-01

An interpretation report, generated with an electronic viewbox, is affected by two factors: image quality, which encompasses what can be seen on the display, and computer human interaction (CHI), which accounts for the cognitive load effect of locating, moving, and manipulating images with the workstation controls. While a number of subject experiments have considered image quality, only recently has the affect of CHI on total interpretation quality been measured. This paper presents the results of a pilot study conducted to evaluate the total interpretation quality of the FilmPlane2.2 radiology workstation for patient folders containing single forty-slice CT studies. First, radiologists interpreted cases and dictated reports using FilmPlane2.2. Requisition forms were provided. Film interpretation was provided by the original clinical report and interpretation forms generated from a previous experiment. Second, an evaluator developed a list of findings for each case based on those listed in all the reports for each case and then evaluated each report for its response on each finding. Third, the reports were compared to determine how well they agreed with one another. Interpretation speed and observation data was also gathered.

Fast 2D FWI on a multi and many-cores workstation.

Science.gov (United States)

Thierry, Philippe; Donno, Daniela; Noble, Mark

2014-05-01

Following the introduction of x86 co-processors (Xeon Phi) and the performance increase of standard 2-socket workstations using the latest 12 cores E5-v2 x86-64 CPU, we present here a MPI + OpenMP implementation of an acoustic 2D FWI (full waveform inversion) code which simultaneously runs on the CPUs and on the co-processors installed in a workstation. The main advantage of running a 2D FWI on a workstation is to be able to quickly evaluate new features such as more complicated wave equations, new cost functions, finite-difference stencils or boundary conditions. Since the co-processor is made of 61 in-order x86 cores, each of them having up to 4 threads, this many-core can be seen as a shared memory SMP (symmetric multiprocessing) machine with its own IP address. Depending on the vendor, a single workstation can handle several co-processors making the workstation as a personal cluster under the desk. The original Fortran 90 CPU version of the 2D FWI code is just recompiled to get a Xeon Phi x86 binary. This multi and many-core configuration uses standard compilers and associated MPI as well as math libraries under Linux; therefore, the cost of code development remains constant, while improving computation time. We choose to implement the code with the so-called symmetric mode to fully use the capacity of the workstation, but we also evaluate the scalability of the code in native mode (i.e running only on the co-processor) thanks to the Linux ssh and NFS capabilities. Usual care of optimization and SIMD vectorization is used to ensure optimal performances, and to analyze the application performances and bottlenecks on both platforms. The 2D FWI implementation uses finite-difference time-domain forward modeling and a quasi-Newton (with L-BFGS algorithm) optimization scheme for the model parameters update. Parallelization is achieved through standard MPI shot gathers distribution and OpenMP for domain decomposition within the co-processor. Taking advantage of the 16

A new workstation based man/machine interface system for the JT-60 Upgrade

International Nuclear Information System (INIS)

Yonekawa, I.; Shimono, M.; Totsuka, T.; Yamagishi, K.

1992-01-01

Development of a new man/machine interface system was stimulated by the requirements of making the JT-60 operator interface more 'friendly' on the basis of the past five-year operational experience. Eleven Sun/3 workstations and their supervisory mini-computer HIDIC V90/45 are connected through the standard network; Ethernet. The network is also connected to the existing 'ZENKEI' mini-computer system through the shared memory on the HIDIC V90/45 mini-computer. Improved software, such as automatic setting of the discharge conditions, consistency check among the related parameters and easy operation for discharge result data display, offered the 'user-friendly' environments. This new man/machine interface system leads to the efficient operation of the JT-60. (author)

A user interface on networked workstations for MFTF-B plasma diagnostic instruments

International Nuclear Information System (INIS)

Balch, T.R.; Renbarger, V.L.

1986-01-01

A network of Sun-2/170 workstations is used to provide an interface to the MFTF-B Plasma Diagnostics System at Lawrence Livermore National Laboratory. The Plasma Diagnostics System (PDS) is responsible for control of MFTF-B plasma diagnostic instrumentation. An EtherNet Local Area Network links the workstations to a central multiprocessing system which furnishes data processing, data storage and control services for PDS. These workstations permit a physicist to command data acquisition, data processing, instrument control, and display of results. The interface is implemented as a metaphorical desktop, which helps the operator form a mental model of how the system works. As on a real desktop, functions are provided by sheets of paper (windows on a CRT screen) called worksheets. The worksheets may be invoked by pop-up menus and may be manipulated with a mouse. These worksheets are actually tasks that communicate with other tasks running in the central computer system. By making entries in the appropriate worksheet, a physicist may specify data acquisition or processing, control a diagnostic, or view a result

Sparx PCA Module

Energy Technology Data Exchange (ETDEWEB)

2017-04-25

Sparx, a new environment for Cryo-EM image processing; Cryo-EM, Single particle reconstruction, principal component analysis; Hardware Req.: PC, MAC, Supercomputer, Mainframe, Multiplatform, Workstation. Software Req.: operating system is Unix; Compiler C++; type of files: source code, object library, executable modules, compilation instructions; sample problem input data. Location/transmission: http://sparx-em.org; User manual & paper: http://sparx-em.org;

The image-interpretation-workstation of the future: lessons learned

Science.gov (United States)

Maier, S.; van de Camp, F.; Hafermann, J.; Wagner, B.; Peinsipp-Byma, E.; Beyerer, J.

2017-05-01

In recent years, professionally used workstations got increasingly complex and multi-monitor systems are more and more common. Novel interaction techniques like gesture recognition were developed but used mostly for entertainment and gaming purposes. These human computer interfaces are not yet widely used in professional environments where they could greatly improve the user experience. To approach this problem, we combined existing tools in our imageinterpretation-workstation of the future, a multi-monitor workplace comprised of four screens. Each screen is dedicated to a special task in the image interpreting process: a geo-information system to geo-reference the images and provide a spatial reference for the user, an interactive recognition support tool, an annotation tool and a reporting tool. To further support the complex task of image interpreting, self-developed interaction systems for head-pose estimation and hand tracking were used in addition to more common technologies like touchscreens, face identification and speech recognition. A set of experiments were conducted to evaluate the usability of the different interaction systems. Two typical extensive tasks of image interpreting were devised and approved by military personal. They were then tested with a current setup of an image interpreting workstation using only keyboard and mouse against our image-interpretationworkstation of the future. To get a more detailed look at the usefulness of the interaction techniques in a multi-monitorsetup, the hand tracking, head pose estimation and the face recognition were further evaluated using tests inspired by everyday tasks. The results of the evaluation and the discussion are presented in this paper.

Validation of a DNA IQ-based extraction method for TECAN robotic liquid handling workstations for processing casework.

Science.gov (United States)

Frégeau, Chantal J; Lett, C Marc; Fourney, Ron M

2010-10-01

A semi-automated DNA extraction process for casework samples based on the Promega DNA IQ™ system was optimized and validated on TECAN Genesis 150/8 and Freedom EVO robotic liquid handling stations configured with fixed tips and a TECAN TE-Shake™ unit. The use of an orbital shaker during the extraction process promoted efficiency with respect to DNA capture, magnetic bead/DNA complex washes and DNA elution. Validation studies determined the reliability and limitations of this shaker-based process. Reproducibility with regards to DNA yields for the tested robotic workstations proved to be excellent and not significantly different than that offered by the manual phenol/chloroform extraction. DNA extraction of animal:human blood mixtures contaminated with soil demonstrated that a human profile was detectable even in the presence of abundant animal blood. For exhibits containing small amounts of biological material, concordance studies confirmed that DNA yields for this shaker-based extraction process are equivalent or greater to those observed with phenol/chloroform extraction as well as our original validated automated magnetic bead percolation-based extraction process. Our data further supports the increasing use of robotics for the processing of casework samples. Crown Copyright © 2009. Published by Elsevier Ireland Ltd. All rights reserved.

Utilization of a multimedia PACS workstation for surgical planning of epilepsy

Science.gov (United States)

Soo Hoo, Kent; Wong, Stephen T.; Hawkins, Randall A.; Knowlton, Robert C.; Laxer, Kenneth D.; Rowley, Howard A.

1997-05-01

Surgical treatment of temporal lobe epilepsy requires the localization of the epileptogenic zone for surgical resection. Currently, clinicians utilize electroencephalography, various neuroimaging modalities, and psychological tests together to determine the location of this zone. We investigate how a multimedia neuroimaging workstation built on top of the UCSF Picture Archiving and Communication System can be used to aid surgical planning of epilepsy and related brain diseases. This usage demonstrates the ability of the workstation to retrieve image and textural data from PACS and other image sources, register multimodality images, visualize and render 3D data sets, analyze images, generate new image and text data from the analysis, and organize all data in a relational database management system.

Development of a graphical user interface allowing use of the SASSYS LMR systems analysis code as an EBR-II interactive simulator

International Nuclear Information System (INIS)

Garner, P.L.; Briggs, L.L.; Gross, K.C.; Ku, J.Y.; Staffon, J.D.

1994-01-01

The SASSYS computer program for safety analyses of liquid-metal- cooled fast reactors has been adapted for use as the simulation engine under the graphical user interface provided by the GRAFUN and HIST programs and the Data Views software package under the X Window System on UNIX-based computer workstations to provide a high fidelity, real-time, interactive simulator of the Experimental Breeder Reactor Number II (EBR-II) plant. In addition to providing analysts with an interactive way of performing safety case studies, the simulator can be used to investigate new control room technologies and to supplement current operator training

A pilot mass-storage system for KEK belle experiment

International Nuclear Information System (INIS)

Fujii, Hirofumi; Itoh, Ryosuke; Manabe, Atsushi; Miyamoto, Akiya; Morita, Youhei; Nozaki, Tadao; Sasaki, Takashi; Watase, Yoshiyuko; Yamakasi, Tokuyuki

1996-01-01

A pilot mass-storage system for KEK Belle (B-meson Physics) experiment has been developed. This experiment requires a high speed and large data recording system. The required recording speed is about 3 MB/sec in average and 15 MB/sec at maximum. The required volume is more than 30 TB/year. We have developed a pilot system to study the high-speed and large volume data recording system which satisfies the above requirements. The system consists of (1) SONY-DIR 1000M data recorder with SCSI-2 Fast/Wide interface; the recording capability of the device is 16MB/sec art maximum. (2) SONY-DMS 24 tape robot (tape library) of which volume capacity is about 2 TB (3) high-speed TCP/IP network of HIPPI and (4) three workstations running under UNIX. For the system software, the CERN-SHIFT system has been installed for the study. Because that the tape device and the robot (tape library) system are completely part. The tape device and the robot (library) control path are directly connected to UNIX workstations. To achieve the required recording speed, we also developed an application interfaces for this tape server. We have made the user interface without using tape stating mechanism. This user interface reduces the overhead of the recording system has developed based on TCP/IP, so that the system is easy to expand and free from network media. (author)

[Influence of different lighting levels at workstations with video display terminals on operators' work efficiency].

Science.gov (United States)

Janosik, Elzbieta; Grzesik, Jan

2003-01-01

The aim of this work was to evaluate the influence of different lighting levels at workstations with video display terminals (VDTs) on the course of the operators' visual work, and to determine the optimal levels of lighting at VDT workstations. For two kinds of job (entry of figures from a typescript and edition of the text displayed on the screen), the work capacity, the degree of the visual strain and the operators' subjective symptoms were determined for four lighting levels (200, 300, 500 and 750 lx). It was found that the work at VDT workstations may overload the visual system and cause eyes complaints as well as the reduction of accommodation or convergence strength. It was also noted that the edition of the text displayed on the screen is more burdening for operators than the entry of figures from a typescript. Moreover, the examination results showed that the lighting at VDT workstations should be higher than 200 lx and that 300 lx makes the work conditions most comfortable during the entry of figures from a typescript, and 500 lx during the edition of the text displayed on the screen.

Stereotactic biopsy aided by a computer graphics workstation: experience with 200 consecutive cases.

Science.gov (United States)

Ulm, A J; Bova, F J; Friedman, W A

2001-12-01

The advent of modern computer technology has made it possible to examine not just the target point, but the entire trajectory in planning for stereotactic biopsies. Two hundred consecutive biopsies were performed by one surgeon, utilizing a computer graphics workstation. The target point, entry point, and complete trajectory were carefully scrutinized and adjusted to minimize potential complications. Pathologically abnormal tissue was obtained in 197 cases (98.5%). There was no mortality in this series. Symptomatic hemorrhages occurred in 4 cases (2%). Computer graphics workstations facilitate safe and effective biopsies in virtually any brain area.

Implementation of Active Workstations in University Libraries—A Comparison of Portable Pedal Exercise Machines and Standing Desks

Directory of Open Access Journals (Sweden)

Camille Bastien Tardif

2018-06-01

Full Text Available Sedentary behaviors are an important issue worldwide, as prolonged sitting time has been associated with health problems. Recently, active workstations have been developed as a strategy to counteract sedentary behaviors. The present study examined the rationale and perceptions of university students’ and staff following their first use of an active workstation in library settings. Ninety-nine volunteers completed a self-administered questionnaire after using a portable pedal exercise machine (PPEM or a standing desk (SD. Computer tasks were performed on the SD (p = 0.001 and paperwork tasks on a PPEM (p = 0.037 to a larger extent. Men preferred the SD and women chose the PPEM (p = 0.037. The appreciation of the PPEM was revealed to be higher than for the SD, due to its higher scores for effective, useful, functional, convenient, and comfortable dimensions. Younger participants (<25 years of age found the active workstation more pleasant to use than older participants, and participants who spent between 4 to 8 h per day in a seated position found active workstations were more effective and convenient than participants sitting fewer than 4 h per day. The results of this study are a preliminary step to better understanding the feasibility and acceptability of active workstations on university campuses.

Effect of Active Workstation on Energy Expenditure and Job Performance: A Systematic Review and Meta-analysis.

Science.gov (United States)

Cao, Chunmei; Liu, Yu; Zhu, Weimo; Ma, Jiangjun

2016-05-01

Recently developed active workstation could become a potential means for worksite physical activity and wellness promotion. The aim of this review was to quantitatively examine the effectiveness of active workstation in energy expenditure and job performance. The literature search was conducted in 6 databases (PubMed, SPORTDiscuss, Web of Science, ProQuest, ScienceDirect, and Scopuse) for articles published up to February 2014, from which a systematic review and meta-analysis was conducted. The cumulative analysis for EE showed there was significant increase in EE using active workstation [mean effect size (MES): 1.47; 95% confidence interval (CI): 1.22 to 1.72, P job performance indicated 2 findings: (1) active workstation did not affect selective attention, processing speed, speech quality, reading comprehension, interpretation and accuracy of transcription; and (2) it could decrease the efficiency of typing speed (MES: -0.55; CI: -0.88 to -0.21, P job performance were significantly lower, others were not. As a result there was little effect on real-life work productivity if we made a good arrangement of job tasks.

Efficient Ada multitasking on a RISC register window architecture

Science.gov (United States)

Kearns, J. P.; Quammen, D.

1987-01-01

This work addresses the problem of reducing context switch overhead on a processor which supports a large register file - a register file much like that which is part of the Berkeley RISC processors and several other emerging architectures (which are not necessarily reduced instruction set machines in the purest sense). Such a reduction in overhead is particularly desirable in a real-time embedded application, in which task-to-task context switch overhead may result in failure to meet crucial deadlines. A storage management technique by which a context switch may be implemented as cheaply as a procedure call is presented. The essence of this technique is the avoidance of the save/restore of registers on the context switch. This is achieved through analysis of the static source text of an Ada tasking program. Information gained during that analysis directs the optimized storage management strategy for that program at run time. A formal verification of the technique in terms of an operational control model and an evaluation of the technique's performance via simulations driven by synthetic Ada program traces are presented.

A study on the fusion reactor - Design study for tokamak control system

Energy Technology Data Exchange (ETDEWEB)

Ko, In Soo; Nam, Kung Won; Cho, Moo Hyun; Kim, Ji Hwa; Kim, Jae Myung; Kim, Sung Chul; Lee, Ki Sun [Pohang University of Science and Technology, Pohang (Korea, Republic of)

1996-09-01

Based on the experience accumulated during the construction of Pohang Light Source, we strongly suggest that the control system must have a hierarchical structure linked with multiple ethernets. Some UNIX-based workstation are recommended in the top layer where KSTAR operators are faced with several control/monitoring windows. As a supervisors to individual subsystem, realtime computers such as VME system are recommended. Choice of realtime operating system is up to the actual developer. However, we strongly suggest to use Lynx which is UNIX-based realtime OS and is getting more attentions after its introduction in the market. Graphic interface for operators will be developed by adopting development toolkit such as RTWorks and EPICS. We also recommend to use EPICS because it is introduced by Los Alamos National Laboratory, U. S. A. and several laboratories around world are now adopting it to their control system. This report is also pointing out several key issues relating the system development. Among them are the cabling plan, signal list, and noise suppressions. It is also suggested that early decision of communication protocol will help to integrated control system in the future. 11 refs., 5 tabs., 4 figs. (author)

From LESSEPS to the workstation for reliability engineers

International Nuclear Information System (INIS)

Ancelin, C.; Bouissou, M.; Collet, J.; Gallois, M.; Magne, L.; Villatte, N.; Yedid, C.; Mulet-Marquis, D.

1994-01-01

Three Mile Island and Chernobyl in the nuclear industry, Challenger, in the space industry, Seveso and Bhopal in the chemical industry - all these accidents show how difficult it is to forecast all likely accident scenarios that may occur in complex systems. This was, however, the objective of the probabilistic safety assessment (PSA) performed by EDF at the Paluel nuclear power plant. The full computerization of this study led to the LESSEPS project, aimed at automating three different steps: generation of reliability models -based on the use of expert systems, qualitative and quantitative processing of these models using computer codes, and overall management of PSA studies. This paper presents the results obtained and the gradual transformation of this first generation of tools into a workstation aimed at integrating reliability studies at all stages of an industrial process. (author)

Computing farms

International Nuclear Information System (INIS)

Yeh, G.P.

2000-01-01

High-energy physics, nuclear physics, space sciences, and many other fields have large challenges in computing. In recent years, PCs have achieved performance comparable to the high-end UNIX workstations, at a small fraction of the price. We review the development and broad applications of commodity PCs as the solution to CPU needs, and look forward to the important and exciting future of large-scale PC computing

A hyperspectral image data exploration workbench for environmental science applications

International Nuclear Information System (INIS)

Woyna, M.A.; Christiansen, J.H.; Zawada, D.G.; Simunich, K.L.

1994-01-01

The Hyperspectral Image Data Exploration Workbench (HIDEW) software system has been developed by Argonne National Laboratory to enable analysts at Unix workstations to conveniently access and manipulate high-resolution imagery data for analysis, mapping purposes, and input to environmental modeling applications. HIDEW is fully object-oriented, including the underlying database. This system was developed as an aid to site characterization work and atmospheric research projects

Automated Status Notification System

Science.gov (United States)

2005-01-01

NASA Lewis Research Center's Automated Status Notification System (ASNS) was born out of need. To prevent "hacker attacks," Lewis' telephone system needed to monitor communications activities 24 hr a day, 7 days a week. With decreasing staff resources, this continuous monitoring had to be automated. By utilizing existing communications hardware, a UNIX workstation, and NAWK (a pattern scanning and processing language), we implemented a continuous monitoring system.

A hyperspectral image data exploration workbench for environmental science applications

Energy Technology Data Exchange (ETDEWEB)

Woyna, M.A.; Christiansen, J.H.; Zawada, D.G.; Simunich, K.L.

1994-08-01

The Hyperspectral Image Data Exploration Workbench (HIDEW) software system has been developed by Argonne National Laboratory to enable analysts at Unix workstations to conveniently access and manipulate high-resolution imagery data for analysis, mapping purposes, and input to environmental modeling applications. HIDEW is fully object-oriented, including the underlying database. This system was developed as an aid to site characterization work and atmospheric research projects.

Application of specialized RISC processor for realization of algorithms for track signal filtration on data read from CCD

International Nuclear Information System (INIS)

Ban, Ya.; Kotov, V.M.; Kharcharufkova, K.

1987-01-01

Algorithms for track signal filtration from bubble and streamer spark chambers read by CCD matrix with elements of 256x288 dimensions are described. The microprogrammed RISC processor is used for preliminary processing and filtration of data obtained. It makes possible to recognize and filter track elements in the zone of 0.25 mm 2 square during 0.17-0.20 s, that maintains it in real time operation

ESCRIME: testing bench for advanced operator workstations in future plants

International Nuclear Information System (INIS)

Poujol, A.; Papin, B.

1994-01-01

The problem of optimal task allocation between man and computer for the operation of nuclear power plants is of major concern for the design of future plants. As the increased level of automation induces the modification of the tasks actually devoted to the operator in the control room, it is very important to anticipate these consequences at the plant design stage. The improvement of man machine cooperation is expected to play a major role in minimizing the impact of human errors on plant safety. The CEA has launched a research program concerning the evolution of the plant operation in order to optimize the efficiency of the human/computer systems for a better safety. The objective of this program is to evaluate different modalities of man-machine share of tasks, in a representative context. It relies strongly upon the development of a specific testing facility, the ESCRIME work bench, which is presented in this paper. It consists of an EDF 1300MWe PWR plant simulator connected to an operator workstation. The plant simulator model presents at a significant level of details the instrumentation and control of the plant and the main connected circuits. The operator interface is based on the generalization of the use of interactive graphic displays, and is intended to be consistent to the tasks to be performed by the operator. The functional architecture of the workstation is modular, so that different cooperation mechanisms can be implemented within the same framework. It is based on a thorough analysis and structuration of plant control tasks, in normal as well as in accident situations. The software architecture design follows the distributed artificial intelligence approach. Cognitive agents cooperate in order to operate the process. The paper presents the basic principles and the functional architecture of the test bed and describes the steps and the present status of the program. (author)

EPRI root cause advisory workstation 'ERCAWS'

International Nuclear Information System (INIS)

Singh, A.; Chiu, C.; Hackman, R.B.

1993-01-01

EPRI and its contractor FPI International are developing Personal Computer (PC), Microsoft Windows based software to assist power plant engineers and maintenance personnel to diagnose and correct root causes of power plant equipment failures. The EPRI Root Cause Advisory Workstation (ERCAWS) is easy to use and able to handle knowledge bases and diagnostic tools for an unlimited number of equipment types. Knowledge base data is based on power industry experience and root cause analysis from many sources - Utilities, EPRI, US government, FPI, and International sources. The approach used in the knowledge base handling portion of the software is case-study oriented with the engineer selecting the equipment type and symptom identification using a combination of text, photographs, and animation, displaying dynamic physical phenomena involved. Root causes, means for confirmation, and corrective actions are then suggested in a simple, user friendly format. The first knowledge base being released with ERCAWS is the Valve Diagnostic Advisor module; covering six common valve types and some motor operator and air operator items. More modules are under development with Heat Exchanger, Bolt, and Piping modules currently in the beta testing stage. A wide variety of diagnostic tools are easily incorporated into ERCAWS and accessed through the main screen interface. ERCAWS is designed to fulfill the industry need for user-friendly tools to perform power plant equipment failure root cause analysis, and training for engineering, operations and maintenance personnel on how components can fail and how to reduce failure rates or prevent failure from occurring. In addition, ERCAWS serves as a vehicle to capture lessons learned from industry wide experience. (author)

Portfolio: a prototype workstation for development and evaluation of tools for analysis and management of digital portal images

International Nuclear Information System (INIS)

Boxwala, Aziz A.; Chaney, Edward L.; Fritsch, Daniel S.; Friedman, Charles P.; Rosenman, Julian G.

1998-01-01

Purpose: The purpose of this investigation was to design and implement a prototype physician workstation, called PortFolio, as a platform for developing and evaluating, by means of controlled observer studies, user interfaces and interactive tools for analyzing and managing digital portal images. The first observer study was designed to measure physician acceptance of workstation technology, as an alternative to a view box, for inspection and analysis of portal images for detection of treatment setup errors. Methods and Materials: The observer study was conducted in a controlled experimental setting to evaluate physician acceptance of the prototype workstation technology exemplified by PortFolio. PortFolio incorporates a windows user interface, a compact kit of carefully selected image analysis tools, and an object-oriented data base infrastructure. The kit evaluated in the observer study included tools for contrast enhancement, registration, and multimodal image visualization. Acceptance was measured in the context of performing portal image analysis in a structured protocol designed to simulate clinical practice. The acceptability and usage patterns were measured from semistructured questionnaires and logs of user interactions. Results: Radiation oncologists, the subjects for this study, perceived the tools in PortFolio to be acceptable clinical aids. Concerns were expressed regarding user efficiency, particularly with respect to the image registration tools. Conclusions: The results of our observer study indicate that workstation technology is acceptable to radiation oncologists as an alternative to a view box for clinical detection of setup errors from digital portal images. Improvements in implementation, including more tools and a greater degree of automation in the image analysis tasks, are needed to make PortFolio more clinically practical

Space station operating system study

Science.gov (United States)

Horn, Albert E.; Harwell, Morris C.

1988-01-01

The current phase of the Space Station Operating System study is based on the analysis, evaluation, and comparison of the operating systems implemented on the computer systems and workstations in the software development laboratory. Primary emphasis has been placed on the DEC MicroVMS operating system as implemented on the MicroVax II computer, with comparative analysis of the SUN UNIX system on the SUN 3/260 workstation computer, and to a limited extent, the IBM PC/AT microcomputer running PC-DOS. Some benchmark development and testing was also done for the Motorola MC68010 (VM03 system) before the system was taken from the laboratory. These systems were studied with the objective of determining their capability to support Space Station software development requirements, specifically for multi-tasking and real-time applications. The methodology utilized consisted of development, execution, and analysis of benchmark programs and test software, and the experimentation and analysis of specific features of the system or compilers in the study.

Beam modelling with a window-oriented user interface

International Nuclear Information System (INIS)

Raich, U.

1990-01-01

In the near future, graphic workstations will be used as replacements for the present operator consoles in the CERN PS accelerator complex. This implies a major change in the style of work for the operators and in the way programs have to be conceived by the programmers. ULTRIX-based (ULTRIX is Digital's version of UNIX) VAX workstations have been selected and DEC-Windows will be used to construct the user interfaces. As a first prototype application, TRACE3D, a beam-transport simulation program, has been adapted to the new environment. This program was an ideal candidate for tests because it needs a great deal of user interaction, while process access is not necessary, at least in a first implementation. This paper describes the different ways in which users interact in order to calculate the beam envelopes, to plot the results, to print out the beam or transport-line parameters, to modify the parameters and to get help. (orig.)

Active Workstations Do Not Impair Executive Function in Young and Middle-Age Adults.

Science.gov (United States)

Ehmann, Peter J; Brush, Christopher J; Olson, Ryan L; Bhatt, Shivang N; Banu, Andrea H; Alderman, Brandon L

2017-05-01

This study aimed to examine the effects of self-selected low-intensity walking on an active workstation on executive functions (EF) in young and middle-age adults. Using a within-subjects design, 32 young (20.6 ± 2.0 yr) and 26 middle-age (45.6 ± 11.8 yr) adults performed low-intensity treadmill walking and seated control conditions in randomized order on separate days, while completing an EF test battery. EF was assessed using modified versions of the Stroop (inhibition), Sternberg (working memory), Wisconsin Card Sorting (cognitive flexibility), and Tower of London (global EF) cognitive tasks. Behavioral performance outcomes were assessed using composite task z-scores and traditional measures of reaction time and accuracy. Average HR and step count were also measured throughout. The expected task difficulty effects were found for reaction time and accuracy. No significant main effects or interactions as a function of treadmill walking were found for tasks assessing global EF and the three individual EF domains. Accuracy on the Tower of London task was slightly impaired during slow treadmill walking for both age-groups. Middle-age adults displayed longer planning times for more difficult conditions of the Tower of London during walking compared with sitting. A 50-min session of low-intensity treadmill walking on an active workstation resulted in accruing approximately 4500 steps. These findings suggest that executive function performance remains relatively unaffected while walking on an active workstation, further supporting the use of treadmill workstations as an effective approach to increase physical activity and reduce sedentary time in the workplace.

Portable image-manipulation software: what is the extra development cost?

Science.gov (United States)

Ligier, Y; Ratib, O; Funk, M; Perrier, R; Girard, C; Logean, M

1992-08-01

A hospital-wide picture archiving and communication system (PACS) project is currently under development at the University Hospital of Geneva. The visualization and manipulation of images provided by different imaging modalities constitutes one of the most challenging component of a PACS. It was necessary to provide this visualization software on a number of types of workstations because of the varying requirements imposed by the range of clinical uses it must serve. The user interface must be the same, independent of the underlying workstation. In addition to a standard set of image-manipulation and processing tools, there is a need for more specific clinical tools that can be easily adapted to specific medical requirements. To achieve this goal, it was elected to develop a modular and portable software called OSIRIS. This software is available on two different operating systems (the UNIX standard X-11/OSF-Motif based workstations and the Macintosh family) and can be easily ported to other systems. The extra effort required to design such software in a modular and portable way was worthwhile because it resulted in a platform that can be easily expanded and adapted to a variety of specific clinical applications. Its portability allows users to benefit from the rapidly evolving workstation technology and to adapt the performance to suit their needs.

TkPl_SU: An Open-source Perl Script Builder for Seismic Unix

Science.gov (United States)

Lorenzo, J. M.

2017-12-01

TkPl_SU (beta) is a graphical user interface (GUI) to select parameters for Seismic Unix (SU) modules. Seismic Unix (Stockwell, 1999) is a widely distributed free software package for processing seismic reflection and signal processing. Perl/Tk is a mature, well-documented and free object-oriented graphical user interface for Perl. In a classroom environment, shell scripting of SU modules engages students and helps focus on the theoretical limitations and strengths of signal processing. However, complex interactive processing stages, e.g., selection of optimal stacking velocities, killing bad data traces, or spectral analysis requires advanced flows beyond the scope of introductory classes. In a research setting, special functionality from other free seismic processing software such as SioSeis (UCSD-NSF) can be incorporated readily via an object-oriented style to programming. An object oriented approach is a first step toward efficient extensible programming of multi-step processes, and a simple GUI simplifies parameter selection and decision making. Currently, in TkPl_SU, Perl 5 packages wrap 19 of the most common SU modules that are used in teaching undergraduate and first-year graduate student classes (e.g., filtering, display, velocity analysis and stacking). Perl packages (classes) can advantageously add new functionality around each module and clarify parameter names for easier usage. For example, through the use of methods, packages can isolate the user from repetitive control structures, as well as replace the names of abbreviated parameters with self-describing names. Moose, an extension of the Perl 5 object system, greatly facilitates an object-oriented style. Perl wrappers are self-documenting via Perl programming document markup language.

Experience with workstations for accelerator control at the CERN SPS

International Nuclear Information System (INIS)

Ogle, A.; Ulander, J.; Wilkie, I.

1990-01-01

The CERN super proton synchrotron (SPS) control system is currently undergoing a major long-term upgrade. This paper reviews progress on the high-level application software with particular reference to the operator interface. An important feature of the control-system upgrade is the move from consoles with a number of fixed screens and limited multitasking ability to workstations with the potential to display a large number of windows and perform a number of independent tasks simultaneously. This workstation environment thus permits the operator to run tasks in one machine for which he previously had to monopolize two or even three old consoles. However, the environment also allows the operator to cover the screen with a multitude of windows, leading to complete confusion. Initial requests to present some form of 'global status' of the console proved to be naive, and several iterations were necessary before the operators were satisfied. (orig.)

Test-retest reliability and concurrent validity of a web-based questionnaire measuring workstation and individual correlates of work postures during computer work

NARCIS (Netherlands)

IJmker, S.; Mikkers, J.; Blatter, B.M.; Beek, A.J. van der; Mechelen, W. van; Bongers, P.M.

2008-01-01

Introduction: "Ergonomic" questionnaires are widely used in epidemiological field studies to study the association between workstation characteristics, work posture and musculoskeletal disorders among office workers. Findings have been inconsistent regarding the putative adverse effect of work

UFMulti: A new parallel processing software system for HEP

Science.gov (United States)

Avery, Paul; White, Andrew

1989-12-01

UFMulti is a multiprocessing software package designed for general purpose high energy physics applications, including physics and detector simulation, data reduction and DST physics analysis. The system is particularly well suited for installations where several workstation or computers are connected through a local area network (LAN). The initial configuration of the software is currently running on VAX/VMS machines with a planned extension to ULTRIX, using the new RISC CPUs from Digital, in the near future.

UFMULTI: A new parallel processing software system for HEP

International Nuclear Information System (INIS)

Avery, P.; White, A.

1989-01-01

UFMulti is a multiprocessing software package designed for general purpose high energy physics applications, including physics and detector simulation, data reduction and DST physics analysis. The system is particularly well suited for installations where several workstations or computers are connected through a local area network (LAN). The initial configuration of the software is currently running on VAX/VMS machines with a planned extension to ULTRIX, using the new RISC CPUs from Digital, in the near future. (orig.)

Clinical impact and value of workstation single sign-on.

Science.gov (United States)

Gellert, George A; Crouch, John F; Gibson, Lynn A; Conklin, George S; Webster, S Luke; Gillean, John A

2017-05-01

CHRISTUS Health began implementation of computer workstation single sign-on (SSO) in 2015. SSO technology utilizes a badge reader placed at each workstation where clinicians swipe or "tap" their identification badges. To assess the impact of SSO implementation in reducing clinician time logging in to various clinical software programs, and in financial savings from migrating to a thin client that enabled replacement of traditional hard drive computer workstations. Following implementation of SSO, a total of 65,202 logins were sampled systematically during a 7day period among 2256 active clinical end users for time saved in 6 facilities when compared to pre-implementation. Dollar values were assigned to the time saved by 3 groups of clinical end users: physicians, nurses and ancillary service providers. The reduction of total clinician login time over the 7day period showed a net gain of 168.3h per week of clinician time - 28.1h (2.3 shifts) per facility per week. Annualized, 1461.2h of mixed physician and nursing time is liberated per facility per annum (121.8 shifts of 12h per year). The annual dollar cost savings of this reduction of time expended logging in is $92,146 per hospital per annum and $1,658,745 per annum in the first phase implementation of 18 hospitals. Computer hardware equipment savings due to desktop virtualization increases annual savings to $2,333,745. Qualitative value contributions to clinician satisfaction, reduction in staff turnover, facilitation of adoption of EHR applications, and other benefits of SSO are discussed. SSO had a positive impact on clinician efficiency and productivity in the 6 hospitals evaluated, and is an effective and cost-effective method to liberate clinician time from repetitive and time consuming logins to clinical software applications. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

The Java Management Extensions (JMX) Is Your Cluster Ready for Evolution?

CERN Document Server

Jaén-Martínez, J

2000-01-01

The arrival of commodity hardware configurations with performance rivaling that offered by RISC workstations is resulting in important advances in the state of the art of building and running very large scalable clusters at "mass market" pricing levels. However, cluster middleware layers are still considered as static infrastructures which are not ready for evolution. In this paper, we claim that middleware layers based on both agent and Java technologies offer new opportunities to support clusters where services can be dynamically added, removed and reconfigured. To support this claim, we present the Java Management Extensions (JMX), a new Java agent based technology, and its application to implement two disjoint cluster management middleware services (a remote reboot service and a distributed infrastructure for collecting Log events) which share a unique agent-based infrastructure.

Reliability and validity of the Khmer version of the 10-item Connor-Davidson Resilience Scale (Kh-CD-RISC10) in Cambodian adolescents.

Science.gov (United States)

Duong, Chanmettachampavieng; Hurst, Cameron P

2016-06-08

Resilience has been characterized as a defensive factor against the refinement of mental health problems. This study adapted the Connor-Davidson Resilience Scale (Kh-CD-RISC10) for use in Khmer adolescents and subsequently investigates its psychometric properties. Using stratified random sampling, this cross-sectional study sampled Cambodian adolescents from high schools selected randomly within three provinces (Phnom Penh, Battambang and Mondulkiri)-location (rural, urban) combinations. Parallel analysis was used to identify the number of component(s), and the structure of the single factor was subsequently explored using principal axis factoring. A confirmatory factor analysis was then performed to establish the fit of the Kh-CD-RISC10 to another sample. To assess convergent validity, the factor scores of the Khmer version of Connor-Davidson Resilience Scale were categorized into three levels, and then the general negative affectivity (GNA) and physiological hyperarousal (PH) scales (derived from the DASS 21) were compared among the three resilience groups. Of the 798 participants who responded (responded rate = 82.26 %), 440 (41.23 %) were female and the age ranged from 14 to 24 years old (mean = 17.36, SD = 1.325). The internal consistency of the Khmer 10-item CD-RISC was also shown to be high in Cambodian adolescents (Cronbach's alpha = 0. 82). Confirmatory factor analysis revealed the single factor model fit data adequately (χ(2) = 100.103, df = 35, p scale of this population, and can be used to assess the resilience comparing to the level of PTSD symptoms in general Khmer adolescent.

Energy consumption of workstations and external devices in school of business and information technology

OpenAIRE

Koret, Jere

2012-01-01

The purpose of this thesis was to measure energy consumption of workstations and external devices in School of Business and Information Technology and search for possible solutions to reduce electricity consumption. The commissionaire for the thesis was Oulu University of Applied Sciences School of Business and Information Management unit. The reason for the study is that School of Business and Information Management has a environmental plan which is based on ISO standard 14001 and this t...

Object-oriented design of medical imaging software.

Science.gov (United States)

Ligier, Y; Ratib, O; Logean, M; Girard, C; Perrier, R; Scherrer, J R

1994-01-01

A special software package for interactive display and manipulation of medical images was developed at the University Hospital of Geneva, as part of a hospital wide Picture Archiving and Communication System (PACS). This software package, called Osiris, was especially designed to be easily usable and adaptable to the needs of noncomputer-oriented physicians. The Osiris software has been developed to allow the visualization of medical images obtained from any imaging modality. It provides generic manipulation tools, processing tools, and analysis tools more specific to clinical applications. This software, based on an object-oriented paradigm, is portable and extensible. Osiris is available on two different operating systems: the Unix X-11/OSF-Motif based workstations, and the Macintosh family.

EPICS Input/Output Controller (IOC) application developer's guide. APS Release 3.12

International Nuclear Information System (INIS)

Kraimer, M.R.

1994-11-01

This document describes the core software that resides in an Input/Output Controller (IOC), one of the major components of EPICS. The basic components are: (OPI) Operator Interface; this is a UNIX based workstation which can run various EPICS tools; (IOC) Input/Output Controller; this is a VME/VXI based chassis containing a Motorola 68xxx processor, various I/O modules, and VME modules that provide access to other I/O buses such as GPIB, (LAN), Local Area Network; and this is the communication network which allows the IOCs and OPIs to communicate. Epics provides a software component, Channel Access, which provides network transparent communication between a Channel Access client and an arbitrary number of Channel Access servers

Assessment of a cooperative workstation.

Science.gov (United States)

Beuscart, R J; Molenda, S; Souf, N; Foucher, C; Beuscart-Zephir, M C

1996-01-01

Groupware and new Information Technologies have now made it possible for people in different places to work together in synchronous cooperation. Very often, designers of this new type of software are not provided with a model of the common workspace, which is prejudicial to software development and its acceptance by potential users. The authors take the example of a task of medical co-diagnosis, using a multi-media communication workstation. Synchronous cooperative work is made possible by using local ETHERNET or public ISDN Networks. A detailed ergonomic task analysis studies the cognitive functioning of the physicians involved, compares their behaviour in the normal and the mediatized situations, and leads to an interpretation of the likely causes for success or failure of CSCW tools.

The BioPhotonics Workstation: from university research to commercial prototype

DEFF Research Database (Denmark)

Glückstad, Jesper

I will outline the specifications of the compact BioPhotonics Workstation we recently have developed that utilizes high-speed spatial light modulation to generate an array of reconfigurable laser-traps making 3D real-time optical manipulation of advanced structures possible with the use of joysti...

Screening for markers of frailty and perceived risk of adverse outcomes using the Risk Instrument for Screening in the Community (RISC).

LENUS (Irish Health Repository)

O Caoimh, Rónán

2014-09-19

Functional decline and frailty are common in community dwelling older adults, increasing the risk of adverse outcomes. Given this, we investigated the prevalence of frailty-associated risk factors and their distribution according to the severity of perceived risk in a cohort of community dwelling older adults, using the Risk Instrument for Screening in the Community (RISC).

DB2 9 for Linux, Unix, and Windows database administration certification study guide

CERN Document Server

Sanders, Roger E

2007-01-01

In DB2 9 for Linux, UNIX, and Windows Database Administration Certification Study Guide, Roger E. Sanders-one of the world's leading DB2 authors and an active participant in the development of IBM's DB2 certification exams-covers everything a reader needs to know to pass the DB2 9 UDB DBA Certification Test (731).This comprehensive study guide steps you through all of the topics that are covered on the test, including server management, data placement, database access, analyzing DB2 activity, DB2 utilities, high availability, security, and much more. Each chapter contains an extensive set of p

Achieving high performance in numerical computations on RISC workstations and parallel systems

Energy Technology Data Exchange (ETDEWEB)

Goedecker, S. [Max-Planck Inst. for Solid State Research, Stuttgart (Germany); Hoisie, A. [Los Alamos National Lab., NM (United States)

1997-08-20

The nominal peak speeds of both serial and parallel computers is raising rapidly. At the same time however it is becoming increasingly difficult to get out a significant fraction of this high peak speed from modern computer architectures. In this tutorial the authors give the scientists and engineers involved in numerically demanding calculations and simulations the necessary basic knowledge to write reasonably efficient programs. The basic principles are rather simple and the possible rewards large. Writing a program by taking into account optimization techniques related to the computer architecture can significantly speedup your program, often by factors of 10--100. As such, optimizing a program can for instance be a much better solution than buying a faster computer. If a few basic optimization principles are applied during program development, the additional time needed for obtaining an efficient program is practically negligible. In-depth optimization is usually only needed for a few subroutines or kernels and the effort involved is therefore also acceptable.

Experience in using workstations as hosts in an accelerator control environment

International Nuclear Information System (INIS)

Abola, A.; Casella, R.; Clifford, T.; Hoff, L.; Katz, R.; Kennell, S.; Mandell, S.; McBreen, E.; Weygand, D.P.

1987-03-01

A new control system has been used for light ion acceleration at the Alternating Gradient Synchrotron (AGS). The control system uses Apollo workstations in the dual role of console hardware computer and controls system host. It has been found that having a powerful dedicated CPU with a demand paging virtual memory OS featuring strong interprocess communication, mapped memory shared files, shared code, and multi-window capabilities, allows us to provide an efficient operation environment in which users may view and manage several control processes simultaneously. The same features which make workstations good console computers also provide an outstanding platform for code development. The software for the system, consisting of about 30K lines of ''C'' code, was developed on schedule, ready for light ion commissioning. System development is continuing with work being done on applications programs

Experience in using workstations as hosts in an accelerator control environment

International Nuclear Information System (INIS)

Abola, A.; Casella, R.; Clifford, T.; Hoff, L.; Katz, R.; Kennell, S.; Mandell, S.; McBreen, E.; Weygand, D.P.

1987-01-01

A new control system has been used for light ion acceleration at the Alternating Gradient Synchrotron (AGS). The control system uses Apollo workstations in the dual role of console hardware computer and controls system host. It has been found that having a powerful dedicated CPU with a demand paging virtual memory OS featuring strong interprocess communication, mapped memory shared files, shared code, and multi-window capabilities, allows us to provide an efficient operation environment in which users may view and manage several control processes simultaneously. The same features which make workstations good console computers also provide an outstanding platform for code development. The software for the system, consisting of about 30K lines of ''C'' code, was developed on schedule, ready for light ion commissioning. System development is continuing with work being done on applications programs

A viral suppressor of RNA silencing inhibits ARGONAUTE 1 function by precluding target RNA binding to pre-assembled RISC.

Science.gov (United States)

Kenesi, Erzsébet; Carbonell, Alberto; Lózsa, Rita; Vértessy, Beáta; Lakatos, Lóránt

2017-07-27

In most eukaryotes, RNA silencing is an adaptive immune system regulating key biological processes including antiviral defense. To evade this response, viruses of plants, worms and insects have evolved viral suppressors of RNA silencing proteins (VSRs). Various VSRs, such as P1 from Sweet potato mild mottle virus (SPMMV), inhibit the activity of RNA-induced silencing complexes (RISCs) including an ARGONAUTE (AGO) protein loaded with a small RNA. However, the specific mechanisms explaining this class of inhibition are unknown. Here, we show that SPMMV P1 interacts with AGO1 and AGO2 from Arabidopsis thaliana, but solely interferes with AGO1 function. Moreover, a mutational analysis of a newly identified zinc finger domain in P1 revealed that this domain could represent an effector domain as it is required for P1 suppressor activity but not for AGO1 binding. Finally, a comparative analysis of the target RNA binding capacity of AGO1 in the presence of wild-type or suppressor-defective P1 forms revealed that P1 blocks target RNA binding to AGO1. Our results describe the negative regulation of RISC, the small RNA containing molecular machine. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

Habitat Demonstration Unit Medical Operations Workstation Upgrades

Science.gov (United States)

Trageser, Katherine H.

2011-01-01

This paper provides an overview of the design and fabrication associated with upgrades for the Medical Operations Workstation in the Habitat Demonstration Unit. The work spanned a ten week period. The upgrades will be used during the 2011 Desert Research and Technology Studies (Desert RATS) field campaign. Upgrades include a deployable privacy curtain system, a deployable tray table, an easily accessible biological waste container, reorganization and labeling of the medical supplies, and installation of a retractable camera. All of the items were completed within the ten week period.

Some Ideas on the Microcomputer and the Information/Knowledge Workstation.

Science.gov (United States)

Boon, J. A.; Pienaar, H.

1989-01-01

Identifies the optimal goal of knowledge workstations as the harmony of technology and human decision-making behaviors. Two types of decision-making processes are described and the application of each type to experimental and/or operational situations is discussed. Suggestions for technical solutions to machine-user interfaces are then offered.…

An advanced tube wear and fatigue workstation to predict flow induced vibrations of steam generator tubes

International Nuclear Information System (INIS)

Gay, N.; Baratte, C.; Flesch, B.

1997-01-01

Flow induced tube vibration damage is a major concern for designers and operators of nuclear power plant steam generators (SG). The operating flow-induced vibrational behaviour has to be estimated accurately to allow a precise evaluation of the new safety margins in order to optimize the maintenance policy. For this purpose, an industrial 'Tube Wear and Fatigue Workstation', called 'GEVIBUS Workstation' and based on an advanced methodology for predictive analysis of flow-induced vibration of tube bundles subject to cross-flow has been developed at Electricite de France. The GEVIBUS Workstation is an interactive processor linking modules as: thermalhydraulic computation, parametric finite element builder, interface between finite element model, thermalhydraulic code and vibratory response computations, refining modelling of fluid-elastic and random forces, linear and non-linear dynamic response and the coupled fluid-structure system, evaluation of tube damage due to fatigue and wear, graphical outputs. Two practical applications are also presented in the paper; the first simulation refers to an experimental set-up consisting of a straight tube bundle subject to water cross-flow, while the second one deals with an industrial configuration which has been observed in some operating steam generators i.e., top tube support plate degradation. In the first case the GEVIBUS predictions in terms of tube displacement time histories and phase planes have been found in very good agreement with experiment. In the second application the GEVIBUS computation showed that a tube with localized degradation is much more stable than a tube located in an extended degradation zone. Important conclusions are also drawn concerning maintenance. (author)

Low dose radiation effects: an integrative european approach (Risc-Rad Project) coordinated by the Cea

International Nuclear Information System (INIS)

Sabatier, L.

2006-01-01

RISC-RAD (Radiosensitivity of Individuals and Susceptibility to Cancer induced by ionizing Radiations) is an Integrated Project funded by the European Commission under 6. Framework Programme / EURATOM. RISC-RAD started on 1. January 2004 for a duration of four years. Coordinated by Cea (Dr Laure Sabatier), it involves 11 European countries (Austria, Denmark, Finland, France, Germany, Ireland, Italy, the Netherlands, Spain, Sweden and the United Kingdom) and 29 research institutions. Objectives: Exposures to low and protracted doses of ionizing radiation are very frequent in normal living environment, at work places, in industry and in medicine. Effects of these exposures on human health cannot be reliably assessed by epidemiological methods, nor is thoroughly understood by biologists. RISC-RAD project proposes to help bridging the gap of scientific knowledge about these effects. To achieve this goal, a necessary key step is to understand the basic mechanisms by which radiation induces cancer. Studying this multistage process in an integrated way, the project offers a new biological approach characterised by and clear-cut and objective-driven scientific policy: the project is focused on the effects of low doses (less than 100 mSv) and protracted doses of radiation. It aims at identifying new parameters that take into account the differences in radiation responses between individuals. A group of modelers works closely with the experimental teams in order to better quantify the risks associated with low and protracted doses. Research work is divided into five work packages interacting closely with each other. WP1 is dedicated to DNA damage. Ionizing Radiation (IR) produce a broad spectrum of base modifications and DNA strand breaks of different kinds, among which double-strand breaks and 'clustered damage' which is thought to be a major feature in biological effectiveness of IR. The aim of Work Package 1 is to improve understanding of the initial DNA damage induced by

Present status and future of the sophisticated work station

Science.gov (United States)

Ishida, Haruhisa

The excellency of the work station is explained, by comparing the functions of software and hardware of work station with those of personal computer. As one of the examples utilizing the functions of work station, desk top publishing is explained. By describing the competition between the Group of ATT · Sun Microsystems which intends to have the leadership by integrating Berkeley version which is most popular at this moment and System V version, and the group led by IBM, future of UNIX as OS of work station is predicted. Development of RISC processor, TRON Plan and Sigma Projects by MITI are also mentioned as its background.

A bench-top automated workstation for nucleic acid isolation from clinical sample types.

Science.gov (United States)

Thakore, Nitu; Garber, Steve; Bueno, Arial; Qu, Peter; Norville, Ryan; Villanueva, Michael; Chandler, Darrell P; Holmberg, Rebecca; Cooney, Christopher G

2018-04-18

Systems that automate extraction of nucleic acid from cells or viruses in complex clinical matrices have tremendous value even in the absence of an integrated downstream detector. We describe our bench-top automated workstation that integrates our previously-reported extraction method - TruTip - with our newly-developed mechanical lysis method. This is the first report of this method for homogenizing viscous and heterogeneous samples and lysing difficult-to-disrupt cells using "MagVor": a rotating magnet that rotates a miniature stir disk amidst glass beads confined inside of a disposable tube. Using this system, we demonstrate automated nucleic acid extraction from methicillin-resistant Staphylococcus aureus (MRSA) in nasopharyngeal aspirate (NPA), influenza A in nasopharyngeal swabs (NPS), human genomic DNA from whole blood, and Mycobacterium tuberculosis in NPA. The automated workstation yields nucleic acid with comparable extraction efficiency to manual protocols, which include commercially-available Qiagen spin column kits, across each of these sample types. This work expands the scope of applications beyond previous reports of TruTip to include difficult-to-disrupt cell types and automates the process, including a method for removal of organics, inside a compact bench-top workstation. Copyright © 2018 Elsevier B.V. All rights reserved.

Development of the real time monitor system

Energy Technology Data Exchange (ETDEWEB)

Kato, Katsumi [Research Organization for Information Science and Technology, Tokai, Ibaraki (Japan); Watanabe, Tadashi; Kaburaki, Hideo

1996-10-01

Large-scale simulation technique is studied at the Center for Promotion of Computational Science and Engineering (CCSE) for the computational science research in nuclear fields. Visualization and animation processing technique are studied and developed for efficient understanding of simulation results. The real time monitor system, in which on-going simulation results are transferred from a supercomputer or workstation to a graphic workstation and are visualized and recorded, is described in this report. This system is composed of the graphic workstation and the video equipment connected to the network. The control shell programs are the job-execution shell for simulations on supercomputers, the file-transfer shell for output files for visualization, and the shell for starting visualization tools. Special image processing technique and hardware are not necessary in this system and the standard visualization tool AVS and the UNIX commands are used, so that this system can be implemented and applied in various computer environments. (author)