Resistance to Inhibitors of Cholinesterase 3 (Ric-3 Expression Promotes Selective Protein Associations with the Human α7-Nicotinic Acetylcholine Receptor Interactome.

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Matthew J Mulcahy

Full Text Available The α7-nicotinic acetylcholine receptor (α7-nAChR is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions. As transmembrane ion channels, α7-nAChRs need to be expressed on the surface of the plasma membrane to function. The receptor has been reported to associate with proteins involved with receptor biogenesis, modulation of receptor properties, as well as intracellular signaling cascades and some of these associated proteins may affect surface expression of α7-nAChRs. The putative chaperone resistance to inhibitors of cholinesterase 3 (Ric-3 has been reported to interact with, and enhance the surface expression of, α7-nAChRs. In this study, we identified proteins that associate with α7-nAChRs when Ric-3 is expressed. Using α-bungarotoxin (α-bgtx, we isolated and compared α7-nAChR-associated proteins from two stably transfected, human tumor-derived cell lines: SH-EP1-hα7 expressing human α7-nAChRs and the same cell line further transfected to express Ric-3, SH-EP1-hα7-Ric-3. Mass spectrometric analysis of peptides identified thirty-nine proteins that are associated with α7-nAChRs only when Ric-3 was expressed. Significantly, and consistent with reports of Ric-3 function in the literature, several of the identified proteins are involved in biological processes that may affect nAChR surface expression such as post-translational processing of proteins, protein trafficking, and protein transport. Additionally, proteins affecting the cell cycle, the cytoskeleton, stress responses, as well as cyclic AMP- and inositol triphosphate-dependent signaling cascades were identified. These results illuminate how α-bgtx may be used to isolate and identify α7-nAChRs as well as how the expression of chaperones such as Ric-3 can influence proteins associating with α7-nAChRs. These associating proteins may alter activities of α7-nAChRs to expand their functionally-relevant repertoire as

Resistance to inhibitors of cholinesterase (Ric-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps34 activity.

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Cedric Boularan

Full Text Available Resistance to inhibitors of cholinesterase (Ric-8A is a guanine nucleotide exchange factor for Gαi, Gαq, and Gα12/13, which is implicated in cell signaling and as a molecular chaperone required for the initial association of nascent Gα subunits with cellular membranes. Ric-8A, Gαi subunits, and their regulators are localized at the midbody prior to abscission and linked to the final stages of cell division. Here, we identify a molecular mechanism by which Ric-8A affects cytokinesis and abscission by controlling Vps34 activity. We showed that Ric-8A protein expression is post-transcriptionally controlled during the cell cycle reaching its maximum levels at mitosis. A FRET biosensor created to measure conformational changes in Ric-8A by FLIM (Fluorescence Lifetime Imaging Microscopy revealed that Ric-8A was in a close-state during mitosis and particularly so at cytokinesis. Lowering Ric-8A expression delayed the abscission time of dividing cells, which correlated with increased intercellular bridge length and multinucleation. During cytokinesis, Ric-8A co-localized with Vps34 at the midbody along with Gαi and LGN, where these proteins functioned to regulate Vps34 phosphatidylinositol 3-kinase activity.

Handlen og væren. Paul Ricœurs polytetiske refleksionsteori

DEFF Research Database (Denmark)

Pallesen, Carsten

erläutert, wie sich die Hermeneutik des Selbst als eine hegelsche Verschiebung der herkömmlichen Subjektsphilosophie verstehen lässt, die jedoch Hegels Begriff des absoluten Wissens durch den Begriff der Bezeugung (attestation) ersetzt. Dieser Begriff wird profiliert in einer textnahen Lektüre von Ricœurs...... Auseinandersetzung mit Husserl, Heidegger und Lévinas, in der Körper, Gewissen und der Andere als konstituierende Passivitätserfahrungen ausgelegt werden, die als solche das Verständnis des Anderssein als ontologischen Begriff für das Selbst begründen. Der fünfte Hauptteil beleuchtet die Attestationshermeneutik...... in zwei unterschiedlichen vorphilosophischen Bereichen: Psychoanalyse und Theologie. Hier wird Ricœurs Theorie der Erinnerung und sein Begriff des Gewissens in gerechtigkeitstheoretischer Perspektive erörtert, die eine gewisse Distanz zu realphilosophischen Bereichen wie z.B. Psychoanalyse und Theologie...

Conference-concert with Frédéric Bernachon on Thursday, 8 March at 6 pm

CERN Multimedia

Staff Association

2018-01-01

The Staff Association is pleased to invite you to an educational conference-concert of classical piano by Frédéric Bernachon « Beethoven : sa vie et son destin au cœur de la sonate Pathétique » on Thursday, 8 March at 6 pm Main Auditorium (500-1-001) Length: 60-90 minutes. Free entrance, cocktails served after the concert. External visitors, please contact the Staff Association for a visitor card: staff.association@cern.ch or +41 22 76 63738 With the help of a piano, Frédéric Bernachon proposes to explain the tragedy of Beethoven, as transmitted in his musical legacy. The listeners will get to experience Ludwig van Beethoven's destiny, suspense, drama and great questions in all their range and variety. After a careful introduction to listening to Sonate Pathétique, Frédéric Bernachon himself interprets this unique piece, through which Beethowen has chosen...

Y. Laberge on Frédéric Salmon's Atlas historique des États-Unis.

Directory of Open Access Journals (Sweden)

2010-06-01

Full Text Available Frédéric Salmon, Atlas historique des États-Unis de 1783 à nos jours. Paris: Armand Colin, 2008. Pp.127. ISBN-13: 978-2200347604  This new, cultural, historical atlas of United States was entirely conceived by a French geographer named Frédéric Salmon; this is not a mere collection of old or already existing maps, but rather a brand new group of unique maps related to the geography, history and demographics of the USA, from the late 18th century to the early 21st century. It should not be mix...

Paul Ricœur: Variations et continuité d'un projet politique

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Pierre-Olivier Monteil

2013-01-01

Full Text Available Les commentateurs s’accordent pour constater une évolution dans la pensée politique de Ricœur conduisant d’un radicalisme à un réformisme. Par-delà ces variations, on se propose plutôt de mettre en évidence la continuité d’un projet. Non seulement la critique du capitalisme se poursuit jusqu’au bout, mais la perspective du socialisme semble très tôt tenue pour improbable. Dans les deux cas, la préoccupation centrale porte sur la nécessité de raviver les traditions et de faire émerger l’élan initial sous la doctrine “ossifiée ” en les situant en tension critique entre elles pour qu’elles se corrigent mutuellement. Le projet politique de Ricœur consiste à établir en vis-à-vis libéralisme et socialisme.

No Space. Nowhere. Refugees and the Problem of Human Rights in Arendt and Ricœur.

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Hille Haker

2018-02-01

Full Text Available In the wake of the recent global refugee and migration crisis, Hannah Arendt’s defense of the right to have political rights has become prominent again. Her work is read as an early reminder that the internationally promoted human rights regime may be merely a rhetorical reference, without the will or international authority for political action. I examine Arendt’s analysis in its historical context and then turn to consider Ricœur’s understanding of human rights. The capability to respond to and to be held accountable by others marks Ricœur’s ethics of responsibility. He agrees with Arendt that legal authority must rest upon power (Macht and not domination (Herrschaft, but he insists that the undercurrent of common power is the moral capability of an agent. The essay examines the ramifications of Ricœur’s ethics for the current crisis of refugees and migration, and it argues that he offers, at the same time, a correction useful for the ethical foundation of human rights.

The guanine nucleotide exchange factor RIC8 regulates conidial germination through Gα proteins in Neurospora crassa.

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Carla J Eaton

Full Text Available Heterotrimeric G protein signaling is essential for normal hyphal growth in the filamentous fungus Neurospora crassa. We have previously demonstrated that the non-receptor guanine nucleotide exchange factor RIC8 acts upstream of the Gα proteins GNA-1 and GNA-3 to regulate hyphal extension. Here we demonstrate that regulation of hyphal extension results at least in part, from an important role in control of asexual spore (conidia germination. Loss of GNA-3 leads to a drastic reduction in conidial germination, which is exacerbated in the absence of GNA-1. Mutation of RIC8 leads to a reduction in germination similar to that in the Δgna-1, Δgna-3 double mutant, suggesting that RIC8 regulates conidial germination through both GNA-1 and GNA-3. Support for a more significant role for GNA-3 is indicated by the observation that expression of a GTPase-deficient, constitutively active gna-3 allele in the Δric8 mutant leads to a significant increase in conidial germination. Localization of the three Gα proteins during conidial germination was probed through analysis of cells expressing fluorescently tagged proteins. Functional TagRFP fusions of each of the three Gα subunits were constructed through insertion of TagRFP in a conserved loop region of the Gα subunits. The results demonstrated that GNA-1 localizes to the plasma membrane and vacuoles, and also to septa throughout conidial germination. GNA-2 and GNA-3 localize to both the plasma membrane and vacuoles during early germination, but are then found in intracellular vacuoles later during hyphal outgrowth.

Chemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRs.

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Alexander Kuryatov

Full Text Available Functional α7 nicotinic acetylcholine receptors (AChRs do not assemble efficiently in cells transfected with α7 subunits unless the cells are also transfected with the chaperone protein RIC-3. Despite the presence of RIC-3, large amounts of these subunits remain improperly assembled. Thus, additional chaperone proteins are probably required for efficient assembly of α7 AChRs. Cholinergic ligands can act as pharmacological chaperones to promote assembly of mature AChRs and upregulate the amount of functional AChRs. In addition, we have found that the chemical chaperones 4-phenylbutyric acid (PBA and valproic acid (VPA greatly increase the amount of functional α7 AChRs produced in a cell line expressing both α7 and RIC-3. Increased α7 AChR expression allows assay of drug action using a membrane potential-sensitive fluorescent indicator. Both PBA and VPA also increase α7 expression in the SH-SY5Y neuroblastoma cell line that endogenously expresses α7 AChRs. VPA increases expression of endogenous α7 AChRs in hippocampal neurons but PBA does not. RIC-3 is insufficient for optimal assembly of α7 AChRs, but provides assay conditions for detecting additional chaperones. Chemical chaperones are a useful pragmatic approach to express high levels of human α7 AChRs for drug selection and characterization and possibly to increase α7 expression in vivo.

Une espérance post-critique ? Enjeux critiques de la conception ricœurienne de l'imaginaire social

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PEGGY AVEZ

2014-12-01

Full Text Available RésuméLa fondation anthropologique de la fonction critique – socialement endossée par l’imaginaire utopique – et son lien dynamique avec la tâche intégrative de l’idéologie permettent à Ricœur de repenser sur le plan socio-politique la double nécessité du soupçon et de l’espérance. En reliant l’analyse de la structure contradictoire et analogisante de l’imaginaire social aux perspectives antérieurement développées sur “la liberté selon l’espérance,” notre propos vise à expliciter ses enjeux émancipateurs. Les apories auxquelles les médiations symboliques contraignent l’agir doivent nourrir la double nécessité d’un “devoir de vigilance” et d’une “timide espérance”: telle est à la fois la difficulté irréductible et la force critique de l’analyse ricœurienne de l’imagination socialisante.Mots-clés: imaginaire social, critique, idéologie, utopie, espérance.AbstractThe anthropological foundation of the critical function—endorsed by the utopian imaginary—and its dynamic relation with the integrative task of ideology allow Ricœur to rethink, at a social and political level, the necessity of both suspicion and hope. Linking Ricœur’s analysis of the contradictory and analogizing structure of the social imaginary to perspectives on “freedom in the light of hope,” which were developed earlier, it is my intention to make explicit certain emancipatory issues. The aporiae to which symbolic mediations constrict acting must provide for the necessity of both an “obligation for vigilance” and a “tentative hope.” Such is the irreducible difficulty but also the critical force of Ricœur’s analysis of the socializing imagination.Keywords: Social Imaginary, Criticism, Ideology, Utopia, Hope.

Paul Ricœur’s Search for a Just Community. The Phenomenological Presupposition of a Life “with and for others”

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Marc De Leeuw

2018-02-01

Full Text Available The aim of this article is to examine how Ricœur’s critique of Husserl’s and Levinas’s notions of intersubjectivity informs his own alternative conceptualization of the intra- and interpersonal as a complex intertwining of moral selfhood and a just community. My first assumption is that law, as a prescriptive intervention in the social structure of our communal life, presupposes a phenomenology of our “being with others”. My second assumption is that Ricœur’s entire philosophical anthropology, and specifically his ideas on ethics, legality and justice, can be read as a prolonged response to Husserl’s solipsistic deadlock in the famous Fifth Cartesian Meditation. Taken together these two assumptions connect Ricœur’s early analysis of phenomenology with his complex reconceptualization of moral selfhood in Oneself as Another, culminating in the ethical maxim of “a good life with and for others in just institutions.”

Matriz binária RiC: classificação filogenética da informação arquivística

OpenAIRE

Macedo, Laureano Secundino Ascensão de

2017-01-01

Ascensão de Macedo, L. S., 2017, "Matriz binária RiC: classificação filogenética da informação arquivística", doi:10.7910/DVN/ERE8HL, Harvard Dataverse, V1 Constam três folhas: 1 - matriz binária com propriedades RiC e taxa (tipologias documentais); 2 - matriz binária simples (processamento em DendroUPGMA); 3 - 3 outputs de DendroUPGMA: matriz bicaudal de similaridade, de distâncias e formato Newick. (2017-01-18)

La métaphore entre sémantique et ontologie. La réception de la philosophie analytique du langage dans l'herméneutique de Paul Ricœur

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Jean-Marc Tétaz

2014-07-01

Full Text Available  AbstractThe favourable reception of the analytic philosophy of language plays a central role in the composition of Ricœur’s literary hermeneutics. Following a brief description of the historical and methodological context of this reception, we show how Ricœur intends to link up phenomenology and analytic philosophy of language. Then we examine the role allocated to the analytic philosophy of language in establishing the idea of metaphor as a “more fundamental mode of reference” in The Rule of Metaphor. But once again Ricœur situates this semantic interpretation of metaphor within the context of an ontology. The result is methodological difficulties that mark the limits of Ricœur’s reception of the analytic philosophy of language.Keywords: Semantics, Metaphor, Ontology, Structuralism, Poetics.RésuméLa réception de la philosophie analytique du langage joue un rôle central dans la constitution de l’herméneutique littéraire de Ricœur. Après avoir tracé le cadre historique et systématique dans lequel s’inscrit cette réception, on montre comment Ricœur se propose d’articuler phénoménologie et philosophie analytique du langage. On étudie ensuite le rôle assigné à la philosophie analytique du langage pour la mise en place de la conception de la métaphore comme “mode plus fondamental de la référence” dans La métaphore vive. Mais Ricœur situe encore une fois cette interprétation sémantique de la métaphore dans un cadre ontologique. Il en résulte des difficultés systématiques qui marquent les limites de la réception de la philosophie analytique du langage par Ricœur.Mots-clés: Sémantique, Métaphore, Ontologie, Structuralisme, Poétique.

[Rethinking ethics with Paul Ricœur. Nursing: between responsibility, care and justice].

Science.gov (United States)

Svandra, Philippe

2016-03-01

In this article, the purpose is less praising Paul Ricoeur's work than enlightening how the reader may actually find some practical, even operative help in this philosophical thought. This is particularly true regarding the fields of medicine and care. Paul Ricœur is now worldwide renowned as a major philosophical figure of the 20th century, and with books such as "Oneself as another", he occupies a very peculiar place at the crossroads of phenomenology and hermeneutics. Through both these philosophical traditions, Paul Ricœur offers some narrative ethics which may greatly sustain caregivers in their reflexion. Yet, the aim of this article is to focus on this philosopher who invites us to inhabit and play a role in this world. The goal is also to bring out the pragmatic ethics that this thinker developed, based on Aristotelian and Kantian traditions. Then, this piece seeks to demonstrate how the three stages of Ricoeur's "petite éthique" (his "small ethics"), which are the self's aim "for the good life with and for others in just institutions" can shed some light on the ethical consideration of politicals and caregivers.

L’identità narrativa ricœuriana alla prova del «nouveau roman» di Robbe-Grillet

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Alberto Romele

2013-12-01

Full Text Available The present essay aims to connect Ricœur’s notion of narrative identity – developed between the 1980s and 1990s – with the nouveau roman theorized by Alain Robbe-Grillet in writings published between 1956 and 1963 and then collected in Pour un noveau roman. In the first part, the essay will summarize Ricœur’s  Aristotelian –apocalyptic narratology model in the light of a comparison with the work of Frank Kermode. In the second part, noveau roman’s ontic realism will be presented. Finally, in the third part, starting with a comparison with the world of computer games, the essay will trace the effect of the overlapping of noveau roman with narrative identity both on the level of description and prescription.

Le premier écrit philosophique de Paul Ricœur: Méthode réflexive appliquée au problème de Dieu chez Lachelier et Lagneau

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Marc-Antoine Vallée

2012-06-01

Full Text Available This paper proposes a presentation and an analysis of the first philosophical writing of Paul Ricœur, on the problem of God in the reflexive philosophies of Lachelier and Lagneau. His principal aim is to situate this first writing in the context of Ricœur’s philosophical work, by underlining his belonging to the french reflexive tradition and his refusing of the absolute idealism of Lachelier and Lagneau. The author insists more precisely on the realistic and personalist thesis of the young Ricœur and on the appearance of the problem of evil in his work.  

Frédéric Hemmer: Serving a world-wide community

CERN Multimedia

2009-01-01

CERN’s IT Department provides a variety of services to the Organization, its users and hundreds of institutes around the world. It plays a vital role in the operation of the LHC and its experiments. This week we meet the new IT Department Head, who tells us about the challenges his teams will face over the coming years. In this period leading up to the first data being produced at the LHC and processed via the Worldwide LHC Computing Grid (WLCG), the IT Department is focussing on service for users and the new Computing Centre which should be built on the Prévessin site. As Frédéric Hemmer, the new IT Department Head, explains, "we are here to serve CERN, its associated institutes and its industrial partners. The Grid is the best illustration of this, but we do have other informatics products that we share with a large number of users across the world, such as INDICO (conference management system) and INVENIO (archiving system used...

D’une convergence remarquable entre phénoménologie et philosophie analytique: la lecture ricœurienne des thèses de Sartre et Ryle sur l’imagination

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Jean-Luc Amalric

2014-07-01

Full Text Available The aim of this article is to analyse the meaning and the implications of the comparative interpretation of Sartre’s and Ryle’s theses on imagination that Ricœur undertook in the still unpublished text of his Lectures on Imagination. These lectures were delivered at the University of Chicago in 1975. First, the article shows how Ricœur brings out a strong convergence, both in the method and in the presuppositions, of the Sartrean and Rylean conceptions of imagination : the choice of a descriptive method leads the two philosophers to a common critique of the mental image. Secondly, the article analyses the properly critical side of the Ricœurian interpretation by showing how it eventually brings to light the common theoretical limitation of Sartre’s and Ryle’s theses on imagination. According to Ricœur, those theses lead to a conception of image as picture and fail to consider the image as fiction, and so they remain locked in a theory of reproductive imagination and of the primacy of perception.RésuméCet article se propose d’analyser le sens et les enjeux de la lecture croisée des thèses de Sartre et Ryle sur l’imagination à laquelle se livre Ricœur dans le texte encore inédit des Lectures on imagination professées en 1975 à l’Université de Chicago. Dans un premier temps, il montre comment Ricœur met en relief une convergence forte, de méthode et de présupposés entre les conceptions sartrienne et rylienne de l’imagination : le choix d’une méthode  descriptive conduisant les deux philosophes à une commune critique de l’image mentale. Puis, dans un second temps, il analyse le versant proprement critique de la lecture ricœurienne en montrant comment elle en vient à dénoncer une commune limitation théorique des thèses de Sartre et Ryle sur l’imagination. Selon Ricœur, ces thèses débouchent sur une conception de l’image comme tableau qui échoue à penser l’image comme fiction et elles restent

Sur la soumission au pouvoir. Convergences et differences entre le Discours de la servitude volontaire d’Etienne de La Boétie et la pensée politique de Paul Ricœur

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Pierre-Olivier Monteil

2017-07-01

Full Text Available This study undertakes a reading of Etienne de La Boétie’s Discours de la servitude volontaire, endeavoring to bring to light the way it convergences with and diverges from the political thought of Paul Ricœur, around the central concept of the will. On the basis of the twin notions of “denaturation” and of “pathology,” a course unfolds which aims at helping establish the people, in comparison with the institution of the State, through a political process revitalised by friendship. But the two thinkers differ when it comes to the resources of the will. This is reflected in the notion of freedom, conceived as absolute in La Boetie, while Ricœur emphasizes its contingency, which leads him to thematize it in terms of capabilities.

Il romanzo moderno nella poetica del sé di Paul Ricœur

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Roberto Talamo

2013-12-01

Full Text Available La riflessione sul romanzo moderno e la nascita di uno dei concetti più importanti dell’ermeneutica del sé, quello di «identità narrativa», sono strettamente intrecciati nel pensiero di Ricœur. Attraverso una lettura di diverse opere del filosofo francese, si mostrerà il percorso di genesi poetica di questo concetto, confrontando altresì la teorizzazione ricoeuriana a proposito del romanzo moderno con le principali acquisizioni su questa forma letteraria da parte della critica e della teoria della letteratura.

Ricœur et la théorie de l’action

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Jean-Luc Petit

2014-07-01

Full Text Available  AbstractRicoeur’s Philosophy of the Will is reexamined here both as a source of motivation for his project of dialoguing with the analytic theory of action and as an explanation for the lack of response on the part of his Anglo-American interlocutors.Keywords: Actions, Language, Body, Idealism. RésuméLa Philosophie de la volonté de Ricœur est revisitée ici comme source de motivation de son entreprise de dialogue avec la théorie analytique de l’action et comme explication du défaut de réponse de ses interlocuteurs anglo-américains.Mots-clés: Actions, Langage, Corps, Idéalisme.

La costellazione dei generi: forme letterarie e modi del discorso nel pensiero di Paul Ricœur

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Roberto Talamo

2013-12-01

Full Text Available Il pensiero filosofico di Ricœur si è sviluppato attraverso un costante e proficuo confronto con le diverse forme della letteratura antica e moderna. Con una carrellata attraverso i testi del filosofo e quelli dei principali interpreti della sua riflessione, si ricostruisce la trama significativa dei nessi tra filosofia e generi letterari: questi offrono al pensiero ricoeuriano la possibilità di «pensare di più» i nodi etici del campo filosofico.

The effect of radiation induced electrical conductivity (RIC) on the thermal conductivity

International Nuclear Information System (INIS)

White, D.P.

1993-01-01

Microwave heating of plasmas in fusion reactors requires the development of microwave windows through which the microwaves can pass without great losses. The degradation of the thermal conductivity of alumina in a radiation environment is an important consideration in reliability studies of these microwave windows. Several recent papers have addressed this question at higher temperatures and at low temperatures. The current paper extends the low temperature calculations to determine the effect of phonon-electron scattering on the thermal conductivity at 77 K due to RIC. These low temperature calculations are of interest because the successful application of high power (>1 MW) windows for electron cyclotron heating systems in fusion reactors will most likely require cryogenic cooling to take advantage of the low loss tangent and higher thermal conductivity of candidate window materials at these temperatures

Engineering Evaluation and Assessment (EE and A) Report for the Symbolic and Sub-symbolic Robotics Intelligence Control System (SS-RICS)

Science.gov (United States)

2018-04-01

ARL-TR-8352 ● APR 2018 US Army Research Laboratory Engineering Evaluation and Assessment (EE&A) Report for the Symbolic and Sub...APR 2018 US Army Research Laboratory Engineering Evaluation and Assessment (EE&A) Report for the Symbolic and Sub-symbolic Robotics...Intelligence Control System (SS-RICS) by Troy Dale Kelley and Eric Avery Human Research and Engineering Directorate, ARL Sean McGhee STG Inc

Métaphores, paraboles et analogie: La référence à la théologie dans la pensée de Paul Ricœur

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Gilbert Vincent

2012-12-01

Full Text Available Il est admis que l’étude de la métaphore représente une inflexion décisive dans l’herméneutique de Ricœur. On sait peut-être moins que cette étude est concomitante de celle de la parabole, qui représente une inflexion également notable dans la contribution ricœurienne à l’herméneutique biblique. Il arrive pourtant qu’on tire argument de cette concomitance pour prétendre que le transfert de certains présupposés théologiques (quant à la nature du langage et de la Vérité s’en trouve facilité, et l’on ne craint pas d’avancer que les pages consacrées à l’analogia entis, dans La métaphore vive, prouvent la prégnance d’intérêts théologiques douteux dans l’élaboration de la théorie de la métaphore. Pour contrer cette critique dévastatrice, nous nous appuierons sur certaines analyses d’Umberto Eco, qui impliquent que la question des rapports entre analogia entis et métaphore n’a rien d’épistémologiquement scandaleux, et sur celles d’Alain qui, voici un siècle, a esquissé une interprétation des paraboles très proche de celle de Ricœur.

Radiation- and photoinduced processes in glass-like arsenic trisulfide and triselenide

International Nuclear Information System (INIS)

Matkovskij, A.O.; Shvarts, K.K.; Pirogov, F.V.; Shpotyuk, O.I.; Savitskij, I.V.

1988-01-01

Peculiarities of photo-structural transformations and results of gamma- and electron-radiation effect upon microhardness, optical absorption, IK and EPR spectra have been studied for glassy chalcogenide semiconductors (GCS). It has been shown that high-energy-radiation-induced changes in the GCS physical properties depend on radiation parameters, thermal conditions and the composition of the sample. Mechanisms of radiation-induced transformations (RIC) for glassy arsenic trisulfide and triselenide are discussed. The RIC is supposed to have been predetermined by the following correlated processes: destruction-polymerization, radiation defect formation, and impurity radiolysis. 77 refs.; 10 figs.; 2 tabs

Sobre el realisme històric i el teatre-document (o de quan els autors estudiaven Història

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Ramon X. Rosselló

2000-03-01

Full Text Available Resum: This essay attempts to approach the Catalan theatrical production of the 1960s and 70s related to the theatredocument, with special emphasis on M. Aurèlia Capmany and X. Romeu’s «Qüestions and answers about the Ufe and death of Francesc Layreu lawyerfor the workers of Catalonia» (1970, one of the most outstanding examples of this theatrical formula.Paraules clau: realisme històric; teatre-document; teatre català; anys seixanta i setanta; M. Aurèlia Campmany; Xavier Romeu

Target development for 67Cu, 82Sr radionuclide production at the RIC-80 facility

Science.gov (United States)

Panteleev, V. N.; Barzakh, A. E.; Batist, L. Kh.; Fedorov, D. V.; Ivanov, V. S.; Krotov, S. A.; Molkanov, P. L.; Moroz, F. V.; Orlov, S. Yu.; Volkov, Yu. M.

2018-01-01

A high-current cyclotron C-80 capable of producing 40-80 MeV proton beams with a current of up to 200 μA has been constructed and commissioned at PNPI (Petersburg Nuclear Physics Institute). One of the main goals of cyclotron C-80 is the production of a wide spectrum of medical radionuclides for diagnostics and therapy. To date, the project development of a radioisotope facility RIC-80 (radioisotopes at cyclotron C-80) has been completed. The feature of the project is the use of a mass-separator combined with the ion-target device for obtaining ion beams of radioisotopes with a high purity of separation that is especially important for medical applications. The first results of a new high-temperature method for extracting 82Sr and 67Cu radioisotopes from irradiated targets have been presented.

Entre Ricœur e Derrida: O Perdão Difícil e o Perdão Im-Possível/Between Ricoeur and Derrida: The difficult forgiveness and the Impossible forgiveness

OpenAIRE

Soares, Victor Dias Maia; Universidade do Estado do Rio de Janeiro / Universidade de Coimbra

2017-01-01

Este trabalho tem como objetivo principal promover o diálogo entre Paul Ricœur e Jacques Derrida no que concerne às abordagens que estes dois autores fazem da noção de perdão. A partir disso, discute-se primeiramente a ideia do perdão difícil em Ricœur e, num segundo momento, aquela do perdão im-possível em Derrida. Ainda que falem a partir de posições de fala diferentes, segundo idiomas filosóficos distintos, sustenta-se que a confrontação de ambas as perspectivas nos dá a pensar o perdão de...

A cognitive robotics system: the symbolic and sub-symbolic robotic intelligence control system (SS-RICS)

Science.gov (United States)

Kelley, Troy D.; Avery, Eric

2010-04-01

This paper will detail the progress on the development of the Symbolic and Subsymbolic Robotics Intelligence Control System (SS-RICS). The system is a goal oriented production system, based loosely on the cognitive architecture, the Adaptive Control of Thought-Rational (ACT-R) some additions and changes. We have found that in order to simulate complex cognition on a robot, many aspects of cognition (long term memory (LTM), perception) needed to be in place before any generalized intelligent behavior can be produced. In working with ACT-R, we found that it was a good instantiation of working memory, but that we needed to add other aspects of cognition including LTM and perception to have a complete cognitive system. Our progress to date will be noted and the challenges that remain will be addressed.

L’empathie comme outil herméneutique du soi: Note sur Paul Ricœur et Heinz Kohut

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Michel Dupuis

2011-01-01

Full Text Available Le bref texte que Paul Ricœur consacre en 1986 à la psychanalyse développée par Heinz Kohut révèle une réinterprétation phénoménologique à la fois du contenu et des fonctions de l'empathie, au total considérée comme un véritable outil à l'œuvre dans l'herméneutique du soi. La vision kohutienne de la constitution du soi et du processus thérapeutique analytique produit une espèce de “dé-sentimentalisation” de l'empathie, en soulignant le rôle crucial du transfert intersubjectif, fort à distance de la théorie (freudienne solipsiste de l'ego.The short text published in 1986 by Paul Ricoeur about Heinz Kohut's psychoanalysis of the self reveals a phenomenological reinterpretation of the content and the functions of empathy, finally considered as an effective tool of the hermeneutics of the self. Kohut's model of constitution of the self and of the therapeutic analytical process produces a kind of “de-sentimentalization” of empathy, pointing to the crucial role of intersubjective transfer, far from a (Freudian solipsistic theory of the ego.

Une lecture de Eine Übertragung de Wolfgang Hilbig à la lumière de Paul Ricœur.

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Bénédicte Terrisse

2009-12-01

Full Text Available L’objet de cette étude est de comprendre le roman de Wolfgang Hilbig (1941-2007 Eine Übertragung (1989 à partir de La Métaphore vive de Ricœur et de l’analyse des différents sens du titre du roman (métaphore, transfert, transposition. L’esthétique métaphorique, qui rappelle en de nombreux points l’esthétique mallarméenne, permet à l’auteur de réinterpréter et redécrire la réalité est-allemande en même temps que sa propre biographie. Par le recours au mythe et à l’intertextualité, ces dernières sont assimilées à la modernité esthétique, si bien que la RDA devient le territoire de la littérature moderne. Par la métaphore, Hilbig se réapproprie une réalité définie jusqu’alors par un pouvoir discrétionnaire.Ziel dieses Textes ist es, den Roman Eine Übertragung (1989 von Wolfgang Hilbig (1941-2007 mit Hilfe von Ricœurs La Métaphore vive sowie der Analyse der verschiedenen Titelbedeutungen (als Metapher, Übertragung oder Übersetzung zu verstehen. Diese Ästhetik der Metapher, die in mancher Hinsicht an die Mallarmésche erinnert, ermöglicht es dem Autor, zugleich die Realität der DDR und seine eigene Biographie neu zu interpretieren und zu beschreiben. Durch Rekurs auf Mythos und Intertextualität werden sie der ästhetischen Moderne gleichgesetzt, sodass die DDR zum Ort der Literatur der Moderne wird. Auf diese Weise gelingt es Hilbig, sich eine bis dahin von der politischen Macht dekretierte Wirklichkeit wieder anzueignen.

9/11, Hyperreality, and the Global Body Politic: Frédéric Beigbeder’s Windows on the World

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Jenn Brandt

2015-01-01

Full Text Available This essay argues that the success of Frédéric Beigbeder's Windows on the World is due to Beigbeder's use of the seemingly contradictory genres of autofiction and hyperrealism in the depiction of the terrorist attacks of September 11, 2001. By positioning himself in the text alongside his fictionalized American counterpoint, Beigbeder configures 9/11 as a lived-body experience that models the ways in which the post-9/11 subject was formed within specific political, cultural, and national conditions. The effect of the novel’s hyperrealism is such that Beigbeder simultaneously posits and deconstructs the notion of national identity within the greater contexts of postmodernism and globalization.

[Doctor Albéric Pont (1870-1960). Dental surgeon, doctor and creator of the center of maxillo-facial surgery of Lyon in 1914].

Science.gov (United States)

Riaud, Xavier

2008-01-01

As Stomatologist and Dental Surgeon Albéric Pont founded with six other Dental Surgeons the School of Dentistry in Lyons which he ran for a long time. When he enlisted in the French Army in 1914 he soon became aware of the extent of facial damage that occurred among the injured soldiers. His subsequent decision was to create and run a Centre for maxillofacial surgery in Lyons. He died in 1960 and left a significant scientific work as well as technical elements of surgery, dental index and devices which still bear his name.

Mesures d’eficàcia publicitària i models teòrics de processament de la publicitat en formats off i online

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Miriam Molina Garcia

2013-06-01

Full Text Available L’eficàcia publicitària ha estat i continua sent estudiada per diferents autors utilitzant varies mesures i establint diferents models. S’ha recollit estudis i investigacions dels sector i s’ha observat quines són algunes de les mesures més utilitzades per a l’estudi de l’eficàcia publicitària de formats off i online en els últims anys i en l’actualitat, els resultats són els següents; l’actitud cap a l’anunci (AA, l’actitud cap a la marca (AM, l’actitud cap al producte (AP i la intencionalitat de compra (IC. Amb el temps s’han creat diferents models teòrics per a l’estudi del processament de persuasió publicitària com el Elaboration Likelihood Model (ELM o el Advertising Response Modeling (ARM entre altres. En el present recull d’estudis s’observa com la gran majoria de models de persuasió publicitària no són vigents i funcionals per a l’estudi de l’eficàcia de la publicitat de formats interactius com poden ser els; banners, SMS’s, advergames o branded apps, amb l’excepció d’un model teòric clau que ha marcat un abans i un després en l’àrea d’estudi comentada, el ELM. Validity of theoretical models and advertising effectivness mesures with interactive advertising forms  Abstract The effectiveness of advertising has been and continues to be studied by different authors using various measures and establishing different models. Studies and  research has been collected and it has been observed which measures are most used for the study of advertising effectiveness in recent years and at present, the results are as follows; attitude toward the ad (AA, attitude toward the brand (AM, attitude toward the product (AP and purchase intention (IC. Over time, different theoretical models have been created to study the processing of persuasive advertising as the Elaboration Likelihood Model (ELM and the Advertising Response Modeling (ARM among others. This collection of studies shows how the

Characterization of Radiation Induced Current in RF coils of Linac-MR Systems

Science.gov (United States)

Burke, Benjamin Lester

by up to 60%. The SNR is improved in the images obtained concurrently with radiation if buildup is applied to the coil. The final part examined the effect of RIC on MR image quality. Imaging experiments were performed on the prototype linac-MR system and the RIC-induced signal-to-noise ratio (SNR) degradation of MR images was quantified. An image post-processing algorithm was proposed which removes some of the RIC-corrupted data from the MR images to recover some of the lost image SNR. The presence of RIC in MR RF coils leads to a loss of SNR which is directly related to the linac dose rate. The RIC related loss in SNR is likely to increase for future commercial systems that are likely to provide larger dose rate than the prototype system (250 cGy/min). Some of this SNR loss can be recovered through the use of a post-processing algorithm which removes the RIC artefact from the image k-space.

Combining metric episodes with semantic event concepts within the Symbolic and Sub-Symbolic Robotics Intelligence Control System (SS-RICS)

Science.gov (United States)

Kelley, Troy D.; McGhee, S.

2013-05-01

This paper describes the ongoing development of a robotic control architecture that inspired by computational cognitive architectures from the discipline of cognitive psychology. The Symbolic and Sub-Symbolic Robotics Intelligence Control System (SS-RICS) combines symbolic and sub-symbolic representations of knowledge into a unified control architecture. The new architecture leverages previous work in cognitive architectures, specifically the development of the Adaptive Character of Thought-Rational (ACT-R) and Soar. This paper details current work on learning from episodes or events. The use of episodic memory as a learning mechanism has, until recently, been largely ignored by computational cognitive architectures. This paper details work on metric level episodic memory streams and methods for translating episodes into abstract schemas. The presentation will include research on learning through novelty and self generated feedback mechanisms for autonomous systems.

Histoire et vérité chez Paul Ricœur et Thucydide: mimesis et enargeia

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Martinho Tomé Soares

2017-07-01

Full Text Available Cet article essaye d’analyser l’Histoire de la Guerre du Péloponnèse de Thucydide à la lumière des thèses ricœuriennes sur l’épistémologie de la connaissance historique, notamment les trois moments essentiels de l’opération historiographique : la preuve documentaire, l’explication/compréhension et l’écriture/représentation. Ce qui nous amène à insérer le texte de Thucydide dans la séquence des trois phases de la mimésis impliquée dans toute mise en discours : préfiguration, configuration, refiguration. Le dialogue que nous établissons entre le philosophe français et l’historien grec nous permet aussi de trouver plusieurs dissimilitudes et similitudes entre les deux, soit en réfléchissant sur la question de la vérité, soit en réfléchissant sur la dialectique entre lire et voir, sous le signe du concept rhétorique de l’enargeia.

Entretiens Jacques Cordonier, Alain Jacquesson, Jean-Frédéric Jauslin, Hubert Villard

CERN Document Server

2016-01-01

Beaucoup d’usages sont tellement ancrés dans nos vies que l’on ne s’interroge guère sur la manière dont ils sont advenus. Les réseaux informatiques, les échanges qu’ils génèrent, semblent aujourd’hui aussi « naturels » aux digital natives que la conversation à distance par téléphones fixes allait de soi il y a cinquante ans. Pour autant que l’on se pose la question, il est difficile d’imaginer qu’un domaine institutionnel, celui des bibliothèques en l’occurrence, ait joué un rôle important dans l’avènement et l’expansion de ces réseaux, au plan suisse voire international, et, par voie de conséquence, dans le développement et la normalisation des échanges intercantonaux. Cela est néanmoins une réalité. Ce livre d’entretiens fait apparaître en quoi Jacques Cordonier, Alain Jacquesson, Jean-Frédéric Jauslin et Hubert Villard, directeurs romands parmi les plus marquants de la fin du 20 e siècle, chacun avec son regard et sa tessiture, dans son canton ou à ...

The International River Interface Cooperative: Public Domain Software for River Flow and Morphodynamics (Invited)

Science.gov (United States)

Nelson, J. M.; Shimizu, Y.; McDonald, R.; Takebayashi, H.

2009-12-01

The International River Interface Cooperative is an informal organization made up of academic faculty and government scientists with the goal of developing, distributing and providing education for a public-domain software interface for modeling river flow and morphodynamics. Formed in late 2007, the group released the first version of this interface (iRIC) in late 2009. iRIC includes models for two and three-dimensional flow, sediment transport, bed evolution, groundwater-surface water interaction, topographic data processing, and habitat assessment, as well as comprehensive data and model output visualization, mapping, and editing tools. All the tools in iRIC are specifically designed for use in river reaches and utilize common river data sets. The models are couched within a single graphical user interface so that a broad spectrum of models are available to users without learning new pre- and post-processing tools. The first version of iRIC was developed by combining the USGS public-domain Multi-Dimensional Surface Water Modeling System (MD_SWMS), developed at the USGS Geomorphology and Sediment Transport Laboratory in Golden, Colorado, with the public-domain river modeling code NAYS developed by the Universities of Hokkaido and Kyoto, Mizuho Corporation, and the Foundation of the River Disaster Prevention Research Institute in Sapporo, Japan. Since this initial effort, other Universities and Agencies have joined the group, and the interface has been expanded to allow users to integrate their own modeling code using Executable Markup Language (XML), which provides easy access and expandability to the iRIC software interface. In this presentation, the current components of iRIC are described and results from several practical modeling applications are presented to illustrate the capabilities and flexibility of the software. In addition, some future extensions to iRIC are demonstrated, including software for Lagrangian particle tracking and the prediction of

The Need for an Alternative Narrative to the History of Ideas or To Pay a Debt to Women: A Feminist Approach to Ricœur's Thought

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Fernanda Henriques

2013-06-01

Full Text Available This paper explores the thought of Paul Ricœur from a feminist point of view. My goal is to show that it is necessary to narrate differently the history of our culture – in particular, the history of philosophy – in order for wommen to attain a self-representation that is equal to that of men. I seek to show that Ricoeur’s philosophy – especially his approach to the topics of memory and history, on the one hand, and the human capacity for initiative, on the other hand– can support the idea that it is possible and legitimate to tell our history otherwise by envisioning a more accurate truth about ourselves. 

Peire Bremon Ricas Novas, “Rics pres, ferms e sobeirans” (BdT 330.15a

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Paolo Di Luca

2008-03-01

Full Text Available This article provides a new critical edition and a commentary of Peire Bremon Ricas Novas’s “Rics pres, ferms e sobeirans”, a courtly love song composed between 1228 and 1257 and dedicated to Audiart del Baux. Built as a eulogy of the lady, the song focuses on the central theme of the moral and material ‘ricor’ (richness of the latter. The complexity of the metrical form, which displays a systematic use of the technique of ‘rim derivatiu’, is paralleled by the semantic obscurity of a number of verses and hapaxes, all discussed in the commentary. Stanzas III and IV show echoes of Jaufre Rudel’s “amor de lonh”, since the lover-poet declares that the distance and the ethnical difference between himself and the lady are abolished by the strength of his feelings. The use of ethnonyms in stanza IV is closely examined: the lover-poet reveals that he loves a Castilian lady who looks like a ‘Serrana’ (the name of an Iberian population, admitting that he would like her even if she were Catalan or Syrian. These references to the lady’s ethnical origins are puzzling: they can be read as a calembour with burlesque overtones, as well as a climax aiming to define the real provenance of the lady or as a rhetorical device to underline that courtly love does not know any kind of boundary.

Les illusions perdues. Süssmilch, l’Académie de Berlin et Frédéric II : échec d’une politique de population

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Jean-Marc Rohrbasser

2011-08-01

Full Text Available Le pasteur Süssmilch, après avoir publié en 1741 la première version de son ouvrage majeur, L’ordre divin dans les changements de l’espèce humaine, est agrégé à l’Académie des sciences de Prusse. L’ouvrage expose une application particulière d’une doctrine alors très en vogue : la théologie physique. En effet, selon Süssmilch, les phénomènes démographiques tels que la natalité, la nuptialité et la mortalité sont régis par la volonté divine et sa providence. À l’Académie, Süssmilch lit de nombreuses communications portant sur l’histoire de la Prusse, l’origine des langues et sur son objet de prédilection : l’explication des phénomènes démographiques par une régularité statistique elle-même ouvrage de Dieu.L’objet de la présente communication est de tenter d’expliquer pourquoi Süssmilch, pasteur luthérien, ne devient pas le conseiller du prince qu’il pense pouvoir être et aspire à être. Le pasteur déclare ouvertement avoir des visées pratiques, voire politiques. Sa position sociale et ses recherches sur la population en font un membre possible du gouvernement de l’état frédéricien. Il demeure cependant un haut fonctionnaire de la hiérarchie ecclésiastique luthérienne. Comment cela s’explique-t-il ?Après avoir sommairement décrit l’activité savante de Süssmilch à l’Académie et comment est accueilli et se diffuse le savoir qu’il tente d’y introduire, je montrerai qu’une conjoncture favorable à ses desseins politiques paraissait présider à sa carrière. Süssmilch arrive en effet au bon moment : il n’a que cinq ans de plus que Frédéric II, et l’accession au trône de ce dernier coïncide avec le début de la carrière du pasteur. Les circonstances sont favorables, et Süssmilch, indiquant l’utilité de ses recherches, insiste sur leur portée politique.J’exposerai ensuite en quoi le roi et le pasteur tombent d’accord. Les vues de Süssmilch et

Definició de dues tipologies de vestit a través del seu ús històric: la indumentària d'arrel tradicional i el vestit d'inspiració internacional

OpenAIRE

Casal-Valls, Laura

2015-01-01

Resum:En aquest article s’estudia el vestit a través del seu ús històric per tal de definir-ne dues tipologies. A través d’una reflexió sobre les diferències entre el vestit i la moda, es defineixen dos grans grups d’indumentària: la indumentària tradicional i el vestit d’inspiració internacional. Tot i que aquest treball se centra en les col·leccions catalanes, la perspectiva d’estudi proposada pot servir per observar peces de geografies diverses.Resumen:Definición de dos tipologías de vesti...

Paul Ricœurs Suche nach einer Neubegründung der Menschenrechte und der Würde durch die Fähigkeiten und die Anwendung der phronèsis

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Yvanka B. Raynova

2016-12-01

The aim of the following article is to reconstruct Paul Ricoeur's concepts of human rights and human dignity by exploring some little-known texts, and to exemplify how these concepts are connected to a specific philosophical conception of human being, which is grounded in a Dialectics between transcendence and incarnation, freedom and dependence, identity and difference, capability and fallibility (fragility. In doing so, I will argue that Ricœur interprets human dignity, which he has never explicitly defined, through the prism of human capabilities, especially of the capability of being responsible. This interpretation allows him to take a differentiated position in the current bioethical debates on the rights of "potential persons" (Embrio and to illustrate how the Aristotelian phronèsis can be used in (bioethical cases where decisions are difficult to take.

Umbilical cord blood as an alternative source of reduced-intensity hematopoietic stem cell transplantation for chronic Epstein-Barr virus-associated T or natural killer cell lymphoproliferative diseases.

Science.gov (United States)

Sawada, Akihisa; Inoue, Masami; Koyama-Sato, Maho; Kondo, Osamu; Yamada, Kayo; Shimizu, Mariko; Isaka, Kanako; Kimoto, Tomiko; Kikuchi, Hiroaki; Tokimasa, Sadao; Yasui, Masahiro; Kawa, Keisei

2014-02-01

Chronic Epstein-Barr virus-associated T/natural killer cell lymphoproliferative diseases represented by chronic active Epstein-Barr virus infection are lethal but are curable with several courses of chemotherapy and allogeneic hematopoietic stem cell transplantation (HSCT). Recently, we reported that reduced-intensity conditioning (RIC) provided better outcomes than myeloablative conditioning because RIC was less toxic. However, it was unclear whether cord blood transplantation (CBT) works in the context of RIC. We retrospectively analyzed 17 patients who underwent RIC followed by bone marrow transplantation (RIC-BMT) and 15 patients who underwent RIC followed by CBT (RIC-CBT). The representative regimen was fludarabine and melphalan based. The overall survival rates with RIC-BMT and RIC-CBT were 92.9% ± 6.9% and 93.3% ± 6.4%, respectively (P = .87). One patient died of lung graft-versus-host disease after RIC-BMT, and 1 patient died of multiple viral infections after RIC-CBT. Although cytotoxic chemotherapy was also immunosuppressive and might contribute to better donor cell engraftment after RIC-HSCT, the rate of engraftment failure after RIC-CBT was still higher than that after RIC-BMT (not significant); however, patients who had experienced graft failure were successfully rescued with a second HSCT. Unrelated cord blood can be an alternative source for RIC-HSCT if a patient has no family donor. Copyright © 2014 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Trichomonas vaginalis Repair of Iron Centres Proteins: The Different Role of Two Paralogs.

Science.gov (United States)

Nobre, Lígia S; Meloni, Dionigia; Teixeira, Miguel; Viscogliosi, Eric; Saraiva, Lígia M

2016-06-01

Trichomonas vaginalis, the causative parasite of one of the most prevalent sexually transmitted diseases is, so far, the only protozoan encoding two putative Repair of Iron Centres (RIC) proteins. Homologs of these proteins have been shown to protect bacteria from the chemical stress imposed by mammalian immunity. In this work, the biochemical and functional characterisation of the T. vaginalis RICs revealed that the two proteins have different properties. Expression of ric1 is induced by nitrosative stress but not by hydrogen peroxide, while ric2 transcription remained unaltered under similar conditions. T. vaginalis RIC1 contains a di-iron centre, but RIC2 apparently does not. Only RIC1 resembles bacterial RICs on spectroscopic profiling and repairing ability of oxidatively-damaged iron-sulfur clusters. Unexpectedly, RIC2 was found to bind DNA plasmid and T. vaginalis genomic DNA, a function proposed to be related with its leucine zipper domain. The two proteins also differ in their cellular localization: RIC1 is expressed in the cytoplasm only, and RIC2 occurs both in the nucleus and cytoplasm. Therefore, we concluded that the two RIC paralogs have different roles in T. vaginalis, with RIC2 showing an unprecedented DNA binding ability when compared with all other until now studied RICs. Copyright © 2016 Elsevier GmbH. All rights reserved.

Biochemical signaling by remote ischemic conditioning of the arm versus thigh: Is one raise of the cuff enough?

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Cameron Dezfulian

2017-08-01

Full Text Available Remote Ischemic Conditioning (RIC, induced by brief cycles of ischemia and reperfusion, protects vital organs from a prolonged ischemic insult. While several biochemical mediators have been implicated in RIC's mechanism of action, it remains unclear whether the localization or “dose” of RIC affects the extent of protective signaling. In this randomized crossover study of healthy individuals, we tested whether the number of cycles of RIC and its localization (arm versus thigh determines biochemical signaling and cytoprotection. Subjects received either arm or thigh RIC and then were crossed over to receive RIC in the other extremity. Blood flow, tissue perfusion, concentrations of the circulating protective mediator nitrite, and platelet mitochondrial function were measured after each RIC cycle. We found that plasma nitrite concentration peaked after the first RIC cycle and remained elevated throughout RIC. This plasma nitrite conferred cytoprotection in an in vitro myocyte model of hypoxia/reoxygenation. Notably, though plasma nitrite returned to baseline at 24 h, RIC conditioned plasma still mediated protection. Additionally, no difference in endpoints between RIC in thigh versus arm was found. These data demonstrate that localization and “dose” of RIC does not affect cytoprotection and further elucidate the mechanisms by which nitrite contributes to RIC-dependent protection.

Relaxation model of radiation-induced conductivity in polymers

Science.gov (United States)

Zhutayeva, Yu. R.; Khatipov, S. A.

1999-05-01

The paper suggests a relaxation model of radiation-induced conductivity (RIC) in polymers. According to the model, the transfer of charges generated in the polymer volume by ionizing radiation takes place with the participation of molecular relaxation processes. The mechanism of electron transport consists in the transfer of the charge directly between traps when they draw close to one another due to the rotation of macromolecule segments. The numerical solutions of the corresponding kinetic equations for different distribution functions Q( τ) of the times of molecular relaxation and for different functions of the probability P( τ, τ') of charge transfer in the `overlapping' regions of the diffusion spheres of the segments are analyzed. The relaxation model provides an explanation of the non-Arrhenius behavior of the RIC temperature dependence, the power dependence of RIC on the dose rate with a power index in the interval 0.5-1.0, the appearance of maxima in the curves of the RIC temporal dependence and their irreversible character in the region of large dose rates (more than 1 Gy/s). The model can be used for interpreting polymer RIC in conditions of kinetic mobility of macromolecules.

Cell lines derived from a Medaka radiation-sensitive mutant have defects in DNA double-strand break responses

International Nuclear Information System (INIS)

Hidaka, Masayuki; Oda, Shoji; Mitani, Hiroshi; Kuwahara, Yoshikazu; Fukumoto, Manabu

2010-01-01

It was reported that the radiation-sensitive Medaka mutant 'ric1' has a defect in the repair of DNA double-strand breaks (DSBs) induced by γ-rays during early embryogenesis. To study the cellular response of a ric1 mutant to ionizing radiation (IR), we established the mutant embryonic cell lines RIC1-e9, RIC1-e42, RIC1-e43. Following exposure to γ-irradiation, the DSBs in wild-type cells were repaired within 1 h, while those in RIC1 cells were not rejoined even after 2 h. Cell death was induced in the wild-type cells with cell fragmentation, but only a small proportion of the RIC1 cells underwent cell death, and without cell fragmentation. Although both wild-type and RIC1 cells showed mitotic inhibition immediately after γ-irradiation, cell division was much slower to resume in the wild-type cells (20 h versus 12 h). In both wild-type and RIC1 cells, Ser139 phosphorylated H2AX (γH2AX) foci were formed after γ-irradiation, however, the γH2AX foci disappeared more quickly in the RIC1 cell lines. These results suggest that the instability of γH2AX foci in RIC1 cells cause an aberration of the DNA damage response. As RIC1 cultured cells showed similar defective DNA repair as ric1 embryos and RIC1 cells revealed defective cell death and cell cycle checkpoint, they are useful for investigating DNA damage responses in vitro. (author)

Reusable Rack Interface Controller Common Software for Various Science Research Racks on the International Space Station

Science.gov (United States)

Lu, George C.

2003-01-01

The purpose of the EXPRESS (Expedite the PRocessing of Experiments to Space Station) rack project is to provide a set of predefined interfaces for scientific payloads which allow rapid integration into a payload rack on International Space Station (ISS). VxWorks' was selected as the operating system for the rack and payload resource controller, primarily based on the proliferation of VME (Versa Module Eurocard) products. These products provide needed flexibility for future hardware upgrades to meet everchanging science research rack configuration requirements. On the International Space Station, there are multiple science research rack configurations, including: 1) Human Research Facility (HRF); 2) EXPRESS ARIS (Active Rack Isolation System); 3) WORF (Window Observational Research Facility); and 4) HHR (Habitat Holding Rack). The RIC (Rack Interface Controller) connects payloads to the ISS bus architecture for data transfer between the payload and ground control. The RIC is a general purpose embedded computer which supports multiple communication protocols, including fiber optic communication buses, Ethernet buses, EIA-422, Mil-Std-1553 buses, SMPTE (Society Motion Picture Television Engineers)-170M video, and audio interfaces to payloads and the ISS. As a cost saving and software reliability strategy, the Boeing Payload Software Organization developed reusable common software where appropriate. These reusable modules included a set of low-level driver software interfaces to 1553B. RS232, RS422, Ethernet buses, HRDL (High Rate Data Link), video switch functionality, telemetry processing, and executive software hosted on the FUC computer. These drivers formed the basis for software development of the HRF, EXPRESS, EXPRESS ARIS, WORF, and HHR RIC executable modules. The reusable RIC common software has provided extensive benefits, including: 1) Significant reduction in development flow time; 2) Minimal rework and maintenance; 3) Improved reliability; and 4) Overall

Gamma ray induced electrical conductivity in bisphenol-A type epoxy resin and polyethylene terephthalate

International Nuclear Information System (INIS)

Maeda, Hideaki; Nakakita, Tsuneo

1978-01-01

The insulation materials to support magnets for nuclear fusion reactors are exposed to high energy neutron beam and the gamma ray due to the accompanying induced radio activity through blankets or radiation shields. In such materials, radiation-induced conduction (RIC) is a problem, which occurs due to the charged particles generated in the insulation materials during irradiation. As one of such materials, use of epoxy composite material is expected, but its RIC has been scarcely measured. An approach to measure the wave form of transient current (or electric charge) caused by irradiating the radiation pulses of nano-second order to the materials has been developed. This paper reports the results of having measured RIC in bisphenol-A type epoxy resin at the electric field from 1 x 10 4 to 3 x 10 5 V/cm and γ dose rate from 9 x 10 3 to 9 x 10 5 R/h over the temperature range of -170 deg. C to +110 deg. C. The RIC of polyethylene terephthalate (PET) was also measured in the same regions, whose molecular structure is comparatively similar to the bisphenol-A type epoxy resin, and of which the fundamental processes for RIC have been clarified pretty well. The radiation sources of 4.3 kCi 60 Co of NAIG and 45 kCi 60 Co of JAERI were used. The experimental circuits and the cryostat are described, then as for the results, explanation and discussion are given to the characteristics of induced current, dependence on dose rate and dependence on temperature of RIC conductivity. The process of capturing carrier in deep traps seems to be dominant in the bisphenol-A type epoxy resin, similarly to that of PET. (Wakatsuki, Y.)

Tempering an Enlightened Educator: Frédéric-César de La Harpe at the Russian Imperial Court (1783–1795

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Andrei Yu. Andreev

2017-12-01

Full Text Available Among all the educators who cared for him from his early childhood, Alexander I gave a particular honor to only one, the Swiss teacher Frédéric-César de La Harpe (1754–1838, who, invited to teach the French language, was further his instructor in geography, history, arithmetic, and geometry, as well as the foundations of philosophy. This Swiss teacher has been regarded in historical studies as the fortunate “chosen one” by Catherine II, who summoned him to direct Alexander’s education and who rewarded him accordingly afterwards. The present article peers into the backstage of the long educational process (1783–1795 in which he was engaged, revealing the less idyllic facts. Based on unpublished documents in Russian and Swiss archives, this study presents a picture of the place of an educator on the main stage of his activity, the Russian Imperial court, and thus the interplay of the history of practice and of ideas and their representations. Did La Harpe himself choose to work as an educator? Did Catherine II really search and find the Swiss teacher for his abilities? Did his teaching indeed represent a concretization of Catherine’s thoughts on this matter? And finally, how did La Harpe himself estimate his situation at the court, which was transformed into a “success story” only after 1814? This article, offering some answers to these questions, adds to the analysis the different circumstances of La Harpe’s appearance and later life at the court; the difficulties he faced in spite of the support of Catherine II, which was, regrettably, withdrawn unexpectedly; and, finally, the permanent discrepancies between his pedagogical ideals and the everyday studies in which he engaged.

Determination of Dynamics of Plant Plasma Membrane Proteins with Fluorescence Recovery and Raster Image Correlation Spectroscopy.

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Laňková, Martina; Humpolíčková, Jana; Vosolsobě, Stanislav; Cit, Zdeněk; Lacek, Jozef; Čovan, Martin; Čovanová, Milada; Hof, Martin; Petrášek, Jan

2016-04-01

A number of fluorescence microscopy techniques are described to study dynamics of fluorescently labeled proteins, lipids, nucleic acids, and whole organelles. However, for studies of plant plasma membrane (PM) proteins, the number of these techniques is still limited because of the high complexity of processes that determine the dynamics of PM proteins and the existence of cell wall. Here, we report on the usage of raster image correlation spectroscopy (RICS) for studies of integral PM proteins in suspension-cultured tobacco cells and show its potential in comparison with the more widely used fluorescence recovery after photobleaching method. For RICS, a set of microscopy images is obtained by single-photon confocal laser scanning microscopy (CLSM). Fluorescence fluctuations are subsequently correlated between individual pixels and the information on protein mobility are extracted using a model that considers processes generating the fluctuations such as diffusion and chemical binding reactions. As we show here using an example of two integral PM transporters of the plant hormone auxin, RICS uncovered their distinct short-distance lateral mobility within the PM that is dependent on cytoskeleton and sterol composition of the PM. RICS, which is routinely accessible on modern CLSM instruments, thus represents a valuable approach for studies of dynamics of PM proteins in plants.

Reference: 198 [Arabidopsis Phenome Database[Archive

Lifescience Database Archive (English)

Full Text Available etion of either RIC4 or RIC3 causes tip growth defects that are rescued by overproduction or depletion...C4. RIC4 promotes F-actin assembly, whereas RIC3 activates Ca(2+) signaling that leads to F-actin disassembly. Overproduction or depl

Rituximab-containing reduced-intensity conditioning improves progression-free survival following allogeneic transplantation in B cell non-Hodgkin lymphoma

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Narendranath Epperla

2017-06-01

Full Text Available Abstract Background In B cell non-Hodgkin lymphoma (B-NHL, rituximab-containing reduced-intensity conditioning regimens (R-RIC have been shown to provide favorable outcomes in single-arm studies; however, large multicenter studies comparing R-RIC and non-rituximab-containing reduced-intensity conditioning regimens (nonR-RIC have not been performed. Using the CIBMTR database, we report the outcomes of R-RIC versus nonR-RIC regimens in B-NHL. Methods We evaluated 1401 adult B-NHL patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT who received nonR-RIC (n = 1022 or R-RIC (n = 379 regimens. Graft-versus-host disease (GVHD prophylaxis was limited to calcineurin inhibitor-based approaches. Results Median follow-up of survivors in the R-RIC and nonR-RIC groups was 47 and 37 months, respectively. On multivariate analysis, no difference was seen between the R-RIC and nonR-RIC cohorts in terms of acute GVHD grade II–IV (RR = 1.14, 95%CI = 0.83–1.56, p = 0.43 or grade III–IV (RR = 1.16, 95%CI = 0.72–1.89, p = 0.54, chronic GVHD (RR = 1.15, 95%CI = 0.92–1.46, p = 0.22, non-relapse mortality (RR = 0.90; 95%CI = 0.67–1.22; p = 0.51, relapse/progression (RR = 0.79; 95%CI = 0.63–1.01; p = 0.055, and mortality (RR = 0.84, 95%CI = 0.69–1.02, p = 0.08 risk. However, R-RIC was associated with a significantly improved progression-free survival (RR = 0.76; 95%CI 0.62–0.92; p = 0.006. On subgroup analysis, mortality benefit was noted in the R-RIC group patients not receiving busulfan-based RIC (RR = 0.76; 95%CI = 0.60–0.96; p = 0.02 and with the use of a higher cumulative rituximab dose (RR = 0.43; 95%CI = 0.21–0.90; p = 0.02. Conclusion Our analysis shows that inclusion of rituximab in RIC regimens improves progression-free survival in patients with B cell NHL. These data supports the use of R-RIC in B

Radiation induced currents in MRI RF coils: application to linac/MRI integration

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Burke, B.; Fallone, B. G.; Rathee, S.

2010-02-01

The integration of medical linear accelerators (linac) with magnetic resonance imaging (MRI) systems is advancing the current state of image-guided radiotherapy. The MRI in these integrated units will provide real-time, accurate tumor locations for radiotherapy treatment, thus decreasing geometric margins around tumors and reducing normal tissue damage. In the real-time operation of these integrated systems, the radiofrequency (RF) coils of MRI will be irradiated with radiation pulses from the linac. The effect of pulsed radiation on MRI radio frequency (RF) coils is not known and must be studied. The instantaneous radiation induced current (RIC) in two different MRI RF coils were measured and presented. The frequency spectra of the induced currents were calculated. Some basic characterization of the RIC was also done: isolation of the RF coil component responsible for RIC, dependence of RIC on dose rate, and effect of wax buildup placed on coil on RIC. Both the time and frequency characteristics of the RIC were seen to vary with the MRI RF coil used. The copper windings of the RF coils were isolated as the main source of RIC. A linear dependence on dose rate was seen. The RIC was decreased with wax buildup, suggesting an electronic disequilibrium as the cause of RIC. This study shows a measurable RIC present in MRI RF coils. This unwanted current could be possibly detrimental to the signal to noise ratio in MRI and produce image artifacts.

Small RNA-based feedforward loop with AND-gate logic regulates extrachromosomal DNA transfer in Salmonella.

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Papenfort, Kai; Espinosa, Elena; Casadesús, Josep; Vogel, Jörg

2015-08-25

Horizontal gene transfer via plasmid conjugation is a major driving force in microbial evolution but constitutes a complex process that requires synchronization with the physiological state of the host bacteria. Although several host transcription factors are known to regulate plasmid-borne transfer genes, RNA-based regulatory circuits for host-plasmid communication remain unknown. We describe a posttranscriptional mechanism whereby the Hfq-dependent small RNA, RprA, inhibits transfer of pSLT, the virulence plasmid of Salmonella enterica. RprA employs two separate seed-pairing domains to activate the mRNAs of both the sigma-factor σ(S) and the RicI protein, a previously uncharacterized membrane protein here shown to inhibit conjugation. Transcription of ricI requires σ(S) and, together, RprA and σ(S) orchestrate a coherent feedforward loop with AND-gate logic to tightly control the activation of RicI synthesis. RicI interacts with the conjugation apparatus protein TraV and limits plasmid transfer under membrane-damaging conditions. To our knowledge, this study reports the first small RNA-controlled feedforward loop relying on posttranscriptional activation of two independent targets and an unexpected role of the conserved RprA small RNA in controlling extrachromosomal DNA transfer.

Feasibility of high temporal resolution breast DCE-MRI using compressed sensing theory.

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Wang, Haoyu; Miao, Yanwei; Zhou, Kun; Yu, Yanming; Bao, Shanglian; He, Qiang; Dai, Yongming; Xuan, Stephanie Y; Tarabishy, Bisher; Ye, Yongquan; Hu, Jiani

2010-09-01

To investigate the feasibility of high temporal resolution breast DCE-MRI using compressed sensing theory. Two experiments were designed to investigate the feasibility of using reference image based compressed sensing (RICS) technique in DCE-MRI of the breast. The first experiment examined the capability of RICS to faithfully reconstruct uptake curves using undersampled data sets extracted from fully sampled clinical breast DCE-MRI data. An average approach and an approach using motion estimation and motion compensation (ME/MC) were implemented to obtain reference images and to evaluate their efficacy in reducing motion related effects. The second experiment, an in vitro phantom study, tested the feasibility of RICS for improving temporal resolution without degrading the spatial resolution. For the uptake-curve reconstruction experiment, there was a high correlation between uptake curves reconstructed from fully sampled data by Fourier transform and from undersampled data by RICS, indicating high similarity between them. The mean Pearson correlation coefficients for RICS with the ME/MC approach and RICS with the average approach were 0.977 +/- 0.023 and 0.953 +/- 0.031, respectively. The comparisons of final reconstruction results between RICS with the average approach and RICS with the ME/MC approach suggested that the latter was superior to the former in reducing motion related effects. For the in vitro experiment, compared to the fully sampled method, RICS improved the temporal resolution by an acceleration factor of 10 without degrading the spatial resolution. The preliminary study demonstrates the feasibility of RICS for faithfully reconstructing uptake curves and improving temporal resolution of breast DCE-MRI without degrading the spatial resolution.

Radiation-induced conductivity of doped silicon in response to photon, proton and neutron irradiation

International Nuclear Information System (INIS)

Kishimoto, N.; Amekura, H.; Plaksin, O.A.; Stepanov, V.A.

2000-01-01

The opto-electronic performance of semiconductors during reactor operation is restricted by radiation-induced conductivity (RIC) and the synergistic effects of neutrons/ions and photons. The RICs of Si due to photons, protons and pulsed neutrons have been evaluated, aiming at radiation correlation. Protons of 17 MeV with an ionizing dose rate of 10 3 Gy/s and/or photons (hν=1.3 eV) were used to irradiate impurity-doped Si (2x10 16 B atoms/cm 3 ) at 300 and 200 K. Proton-induced RIC (p-RIC) and photoconductivity (PC) were intermittently detected in an accelerator device. Neutron-induced RIC (n-RIC) was measured for the same Si in a pulsed fast-fission reactor, BARS-6, with a 70-μs pulse of 2x10 12 n/cm 2 (E>0.01 MeV) and a dose rate of up to 6x10 5 Gy/s. The neutron irradiation showed a saturation tendency in the flux dependence at 300 K due to the strong electronic excitation. Normalization of the electronic excitation, including the pulsed regime, gave a fair agreement among the different radiation environments. Detailed comparison among PC, p-RIC and n-RIC is discussed in terms of radiation correlation including the in-pile condition

Protective effect of remote limb ischemic perconditioning on the liver grafts of rats with a novel model.

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Junjun Jia

Full Text Available Remote ischemic conditioning (RIC is a known manual conditioning to decrease ischemic reperfusion injury (IRI but not increase ischemic time. Here we tried to establish a rat RIC model of liver transplantation (LT, optimize the applicable protocols and investigate the protective mechanism.The RIC model was developed by a standard tourniquet. Sprague-Dawley rats were assigned randomly to the sham operated control (N, standard rat liver transplantation (OLT and RIC groups. According to the different protocols, RIC group was divided into 3 subgroups (10 min×3, n = 6; 5 min×3, n = 6; 1 min×3, n = 6 respectively. Serum transaminases (ALT, AST, creatine kinase (CK, histopathologic changes, malondialdehyde (MDA, myeloperoxidase (MPO and expressions of p-Akt were evaluated.Compared with the OLT group, the grafts subjected to RIC 5min*3 algorithm showed significant reduction of morphological damage and improved the graft function. Also, production of reactive oxygen species (MDA and neutrophil accumulation (MPO were markedly depressed and p-Akt was upregulated.In conclusion, we successfully established a novel model of RIC in rat LT, the optimal RIC 5min*3 algorithm seemed to be more efficient to alleviate IRI of the liver graft in both functional and morphological categories, which due to its antioxidative, anti-inflammation activities and activating PI3K Akt pathway.

Effectiveness and safety of endoscopic radial incision and cutting for severe benign anastomotic stenosis after surgery for colorectal carcinoma: a three-case series.

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Asayama, Naoki; Nagata, Shinji; Shigita, Kenjiro; Aoyama, Taiki; Fukumoto, Akira; Mukai, Shinichi

2018-03-01

Benign colonic anastomotic stenosis sometimes occurs after surgical resection and usually requires surgical or endoscopic dilation. Limited data are available on the effectiveness and safety of the endoscopic radial incision and cutting (RIC) method at sites other than the esophagus. The aim of this retrospective study was to investigate the effectiveness and safety of RIC dilation for severe benign anastomotic colonic stenosis. Subjects were 3 men (median age 72 years, range 65 - 76 years) who developed severe benign anastomotic stenosis after surgical resection for colorectal carcinoma and were subsequently treated by RIC dilation at Hiroshima City Asa Citizens Hospital between May 2014 and December 2016. Severe anastomotic stenosis was defined as a narrowed anastomosis through which a standard colonoscope could not be passed. The median interval from surgery to RIC was 21 months (range 9 - 29 months). RIC was successful in all 3 patients and reduced the severity of dyschezia postoperatively; 2 patients experienced improvement after a single RIC session and the other after 6 RIC sessions. No treatment-related adverse events or re-stenosis requiring repeat dilation was noted during a median follow-up of 27 months (range 8 - 37 months). Our findings indicate that the RIC technique can be applied safely and effectively to various sites in the colon, avoiding the need for reoperation.

The simplicial Ricci tensor

International Nuclear Information System (INIS)

Alsing, Paul M; McDonald, Jonathan R; Miller, Warner A

2011-01-01

The Ricci tensor (Ric) is fundamental to Einstein's geometric theory of gravitation. The three-dimensional Ric of a spacelike surface vanishes at the moment of time symmetry for vacuum spacetimes. The four-dimensional Ric is the Einstein tensor for such spacetimes. More recently, the Ric was used by Hamilton to define a nonlinear, diffusive Ricci flow (RF) that was fundamental to Perelman's proof of the Poincare conjecture. Analytic applications of RF can be found in many fields including general relativity and mathematics. Numerically it has been applied broadly to communication networks, medical physics, computer design and more. In this paper, we use Regge calculus (RC) to provide the first geometric discretization of the Ric. This result is fundamental for higher dimensional generalizations of discrete RF. We construct this tensor on both the simplicial lattice and its dual and prove their equivalence. We show that the Ric is an edge-based weighted average of deficit divided by an edge-based weighted average of dual area-an expression similar to the vertex-based weighted average of the scalar curvature reported recently. We use this Ric in a third and independent geometric derivation of the RC Einstein tensor in arbitrary dimensions.

The simplicial Ricci tensor

Science.gov (United States)

Alsing, Paul M.; McDonald, Jonathan R.; Miller, Warner A.

2011-08-01

The Ricci tensor (Ric) is fundamental to Einstein's geometric theory of gravitation. The three-dimensional Ric of a spacelike surface vanishes at the moment of time symmetry for vacuum spacetimes. The four-dimensional Ric is the Einstein tensor for such spacetimes. More recently, the Ric was used by Hamilton to define a nonlinear, diffusive Ricci flow (RF) that was fundamental to Perelman's proof of the Poincarè conjecture. Analytic applications of RF can be found in many fields including general relativity and mathematics. Numerically it has been applied broadly to communication networks, medical physics, computer design and more. In this paper, we use Regge calculus (RC) to provide the first geometric discretization of the Ric. This result is fundamental for higher dimensional generalizations of discrete RF. We construct this tensor on both the simplicial lattice and its dual and prove their equivalence. We show that the Ric is an edge-based weighted average of deficit divided by an edge-based weighted average of dual area—an expression similar to the vertex-based weighted average of the scalar curvature reported recently. We use this Ric in a third and independent geometric derivation of the RC Einstein tensor in arbitrary dimensions.

TBC-8, a putative RAB-2 GAP, regulates dense core vesicle maturation in Caenorhabditis elegans.

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Hannemann, Mandy; Sasidharan, Nikhil; Hegermann, Jan; Kutscher, Lena M; Koenig, Sabine; Eimer, Stefan

2012-01-01

Dense core vesicles (DCVs) are thought to be generated at the late Golgi apparatus as immature DCVs, which subsequently undergo a maturation process through clathrin-mediated membrane remodeling events. This maturation process is required for efficient processing of neuropeptides within DCVs and for removal of factors that would otherwise interfere with DCV release. Previously, we have shown that the GTPase, RAB-2, and its effector, RIC-19, are involved in DCV maturation in Caenorhabditis elegans motoneurons. In rab-2 mutants, specific cargo is lost from maturing DCVs and missorted into the endosomal/lysosomal degradation route. Cargo loss could be prevented by blocking endosomal delivery. This suggests that RAB-2 is involved in retention of DCV components during the sorting process at the Golgi-endosomal interface. To understand how RAB-2 activity is regulated at the Golgi, we screened for RAB-2-specific GTPase activating proteins (GAPs). We identified a potential RAB-2 GAP, TBC-8, which is exclusively expressed in neurons and which, when depleted, shows similar DCV maturation defects as rab-2 mutants. We could demonstrate that RAB-2 binds to its putative GAP, TBC-8. Interestingly, TBC-8 also binds to the RAB-2 effector, RIC-19. This interaction appears to be conserved as TBC-8 also interacted with the human ortholog of RIC-19, ICA69. Therefore, we propose that a dynamic ON/OFF cycling of RAB-2 at the Golgi induced by the GAP/effector complex is required for proper DCV maturation.

Electrical Conductivity of Gamma Irradiated Aqueous Urea Solution and its Application for Determination of Absorbed Radiation Dose; Sife-Eldeen Dosimeter

International Nuclear Information System (INIS)

Sife- Eldeen, Kh.A.

2008-01-01

In This Study, the radiation induced electrical conductivity (RIC) of aqueous urea solutions was investigated after gamma radiolysis. It was found that the RIC depends on preirradiation urea concentration, absorbed radiation dose and storage time. At the same absorbed dose, RIC increases as preirradiation urea concentration increases. The RIC change of aqueous urea solutions reaches a maximum value at 3.5 M aqueous urea solutions. RIC of 0.133 and 3.5 M aqueous urea solutions as a function of dose, have been investigated in the range between 2.18 and 119.4 kGy. RIC of the 0.133 and 3.5 M aqueous urea solutions increased linearly with increasing dose (R 2 =0.9963, 0.9972 respectively). The calibration factors was found to be 2.1448 and 9.53 μS/kGy for sets with 0.133 and 3.5 M urea respectively .The coefficient of variation CV %, associated with RIC measurement of 3.5 M aqueous urea solution as a function of absorbed radiation dose was found to be 1.8025% and the uncertainty was found to be 3.6 % and 5.4 % for 95 % and 99 % confidence levels, respectively. The effective atomic number of 3.5 M aqueous urea solutions is 6.58, which indicates tissue equivalency of this system. The RIC values of 3.5 M aqueous urea solutions were found to be relatively stable over storage period of three weeks at 0 degree C. Accordingly, this system could be considered as a promising radiation-sensitive material for dosimetry of gamma rays in both technical and research fields

Allogeneic Hematopoietic Cell Transplantation for Dyskeratosis Congenita: A Report of 3 Cases.

Science.gov (United States)

Tamura, Shinichi; Imamura, Toshihiko; Urata, Takayo; Kobayashi, Miki; Gen, Mari; Tomii, Toshihiro; Do, Junko; Osone, Shinya; Ishida, Hiroyuki; Hosoi, Hajime; Kuroda, Hiroshi

2017-10-01

Although bone marrow failure in patients with dyskeratosis congenita (DKC) can be successfully treated with allogeneic hematopoietic cell transplantation (allo-HCT) using a reduced intensity conditioning (RIC) regimen, the outcome of nonhematological disorders in patients with DKC treated with allo-HCT using RIC has not been fully elucidated. Here, we describe the clinical course of nonhematological disorders after allo-HCT with RIC in 3 consecutive patients with DKC. Allo-HCT with RIC was feasible in all cases; however, patient 1 developed lethal pulmonary disease and patient 2 experienced progression of hepatic fibrosis. Careful follow-up of patient-specific complications is required after allo-HCT in patients with DKC.

Remote ischemic conditioning improves coronary microcirculation in healthy subjects and patients with heart failure

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Kono Y

2014-08-01

Full Text Available Yasushi Kono,1 Shota Fukuda,1 Akihisa Hanatani,2 Koki Nakanishi,2 Kenichiro Otsuka,2 Haruyuki Taguchi,1 Kenei Shimada2 1Department of Medicine, Osaka Ekisaikai Hospital, Osaka, Japan; 2Department of Internal Medicine and Cardiology, Osaka City University School of Medicine, Osaka, Japan Background: Remote ischemic conditioning (RIC is a treatment modality that suppresses inflammation and improves endothelial function, which are factors involved in the pathogenesis of heart failure (HF with reduced left ventricular ejection fraction. Coronary flow reserve (CFR is a physiological index of coronary microcirculation and is noninvasively measured by transthoracic Doppler echocardiography (TTDE. This study aimed to investigate the effects of RIC on CFR in healthy subjects and patients with HF, through the assessment by TTDE. Methods: Ten patients with HF with left ventricular ejection fraction of less than 40%, and ten healthy volunteers were enrolled in this study. RIC treatment was performed twice a day for 1 week. Our custom-made RIC device was programmed to automatically conduct 4 cycles of 5 minutes inflation and 5 minutes deflation of a blood pressure cuff to create intermittent arm ischemia. CFR measurements and laboratory tests were examined before, and after 1 week of RIC treatment. Results: One week of RIC treatment was well tolerated in both groups. RIC treatment increased CFR from 4.0±0.9 to 4.6±1.3 (mean ± standard deviation in healthy subjects (P=0.02, and from 1.9±0.4 to 2.3±0.7 in patients with HF (P=0.03, respectively. Systolic blood pressure in healthy subjects, and heart rate in HF patients decreased after RIC treatment (both P<0.01. Conclusion: This study demonstrated that a 1 week course of RIC treatment improved coronary microcirculation in healthy subjects and patients with HF associated with reduced left ventricular ejection fraction. Keyword: echocardiography, coronary flow reserve, heart failure, preconditioning

Remote ischemic conditioning: A treatment for vascular cognitive impairment

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David C Hess

2015-01-01

Full Text Available There is a strong link between hypoperfusion and white matter (WM damage in patients with leukoaraiosis and vascular cognitive impairment (VCI. Other than management of vascular risk factors, there is no treatment for WM damage and VCI that delays progression of the disease process to dementia. Observational studies suggest that exercise may prevent or slow down the progression of Alzheimer′s disease (AD and VCI. However, getting patients to exercise is challenging, especially with advancing age and disability. Remote ischemic conditioning, an "exercise equivalent," allows exercise to be given with a "device" at home for long periods of time. Since remote ischemic conditioning (RIC increases cerebral blood flow (CBF in preclinical studies and in humans, RIC may be an ideal therapy to treat VCI and WM disease and perhaps even sporadic AD. By using magnetic resonance imaging (MRI imaging of WM progression, a sample size in the range of about 100 subjects per group could determine if RIC has activity in WM disease and VCI.

Être parasité par les fictions des autres. Rôle et (impertinence du personnage de Gabriel Rivages dans la trilogie 1984 d’Éric Plamondon

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René Audet

2015-01-01

Full Text Available Romans fragmentaires autant que romans duels, les trois tomes de la trilogie 1984 d’Éric Plamondon associent chacun à une figure américaine (Weissmuller, Brautigan, Jobs le personnage de Gabriel Rivages, dont le destin est placé en écho à ces mythes. Singulier dans son histoire, Rivages reste toutefois un personnage faible, jouant un rôle de relais et de faire-valoir. Son actantialité réduite pourrait être perçue, à la lumière de la fragmentation romanesque et de l’architecture livresque de cet ensemble, comme le signal d’une individualité tiraillée entre la grandeur du réel mythifié et la faiblesse de la fiction ordinaire. As much fragmentary novels as they are dual novels, each of the three volumes of Eric Plamondon’s 1984 trilogy associates the character Gabriel Rivages with an American figure (Weissmuller, Brautigan, Jobs, placing the destiny of the character as an echo to the myths surrounding each figure. Though unique within his story, Rivages nevertheless remains a weak character, playing the role of relay or foil. His reduced actantiality may be perceived, in light of the novelistic fragmentation and the architecture of the trilogy, as the signal of an individuality caught between the grandeur of a mythologized reality and the feebleness of ordinary fiction.

Radiation-Induced Carotid Artery Stenosis in a Patient with Carcinoma of the Oral Floor

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Kahori Seto

2013-01-01

Full Text Available Radiation-induced carotid artery stenosis (RI-CS, a life-threatening condition, can occur after external radiation for head and neck cancer. We here describe a case of asymptomatic RI-CS in a 73-year-old patient treated with chemoradiotherapy and radical neck dissection for a basaloid squamous cell carcinoma of the oral floor. Stenosis of the left carotid artery, diagnosed as RI-CS, showed on an MRI performed 1.5 years after radiotherapy. Blood from the left side of the anterior cerebral artery and the middle anterior artery was flowing to the brain through the anterior and posterior communicating arteries, so no stent surgery or other treatment was necessary. The cancer has not recurred during approximately 5 years of followup after radiotherapy, and the patient has had no adverse effects from the RI-CS since it was diagnosed 3.5 years ago. This case emphasizes the necessity of early scrutiny for RI-CS in patients given radiotherapy for oral cancer.

Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning.

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Koyama, M; Hashimoto, D; Nagafuji, K; Eto, T; Ohno, Y; Aoyama, K; Iwasaki, H; Miyamoto, T; Hill, G R; Akashi, K; Teshima, T

2014-01-01

Graft rejection remains a major obstacle in allogeneic hematopoietic SCT following reduced-intensity conditioning (RIC-SCT), particularly after cord blood transplantation (CBT). In a murine MHC-mismatched model of RIC-SCT, primary graft rejection was associated with activation and expansion of donor-reactive host T cells in peripheral blood and BM early after SCT. Donor-derived dendritic cells are at least partly involved in host T-cell activation. We then evaluated if such an expansion of host T cells could be associated with graft rejection after RIC-CBT. Expansion of residual host lymphocytes was observed in 4/7 patients with graft rejection at 3 weeks after CBT, but in none of the 17 patients who achieved engraftment. These results suggest the crucial role of residual host T cells after RIC-SCT in graft rejection and expansion of host T cells could be a marker of graft rejection. Development of more efficient T cell-suppressive conditioning regimens may be necessary in the context of RIC-SCT.

Modulation of functionally localized right insular cortex activity using real-time fMRI-based neurofeedback

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Brian D Berman

2013-10-01

Full Text Available The capacity for subjects to learn to volitionally control localized brain activity using neurofeedback is actively being investigated. We aimed to investigate the ability of healthy volunteers to quickly learn to use visual feedback during real-time functional MRI (rtfMRI to modulate brain activity within their anterior right insular cortex (RIC localized during a blink suppression task, an approach of possible interest in the use of rtfMRI to reduce urges. The RIC region of interest (RIC-ROI was functionally localized using a blink suppression task, and BOLD signal changes within RIC-ROI used to create a constantly updating display fed back to the subject in the scanner. Subjects were instructed to use emotional imagery to try and increase activity within RIC-ROI during four feedback training runs (FB1–FB4. A ‘control’ run (CNTRL before training and a ‘transfer’ run (XSFR after training were performed without feedback to assess for baseline abilities and learning effects. Fourteen participants completed all neurofeedback training runs. At the group level, increased BOLD activity was seen in the anterior RIC during all the FB runs, but a significant increase in the functionally defined RIC-ROI was only attained during FB2. In atlas-defined insular cortex ROIs, significant increases were seen bilaterally during the CNTRL, FB1, FB2, and FB4 runs. Increased activity within the insular cortices did not show lateralization. Training did, however, result in a significant increase in functional connectivity between the RIC-ROI and the medial frontal gyrus when comparing FB4 to FB1. Since neurofeedback training did not lead to an increase in BOLD signal across all feedback runs, we suggest that learning to control one’s brain activity in this fashion may require longer or repeated rtfMRI training sessions.

A comparative assessment of the curative potential of reduced intensity allografts in acute myeloid leukaemia

DEFF Research Database (Denmark)

Russell, N H; Kjeldsen, L; Craddock, C

2015-01-01

was to determine which approach improved survival and within which prespecified cytogenetic groups. RIC transplants significantly reduced relapse (adjusted hazard ratio (HR) 0.66 (0.50-0.85), P=0.002) compared to chemotherapy The 5-year overall survival from a sibling RIC (61%) was superior to a MUD RIC (37......%; adjusted HR 1.50 (1.01-2.21), P=0.04) due to lower NRM (34 vs 14%, P=0.002) In adjusted analyses, there was a survival benefit for sibling RIC over chemotherapy (59 vs 49%, HR 0.75 (0.57-0.97), P=0.03), with consistent results in intermediate and adverse-risk patients. In patients aged 35-44 years, best...

Survival benefits of remote ischemic conditioning in sepsis.

Science.gov (United States)

Joseph, Bellal; Khalil, Mazhar; Hashmi, Ammar; Hecker, Louise; Kulvatunyou, Narong; Tang, Andrew; Friese, Randall S; Rhee, Peter

2017-06-01

Sepsis remains the leading cause of death in the surgical intensive care unit. Prior studies have demonstrated a survival benefit of remote ischemic conditioning (RIC) in many disease states. The aim of this study was to determine the effects of RIC on survival in sepsis in an animal model and to assess alterations in inflammatory biochemical profiles. We hypothesized that RIC alters inflammatory biochemical profiles resulting in decreased mortality in a septic mouse model. Eight to 12 week C57BL/6 mice received intra-peritoneal injection of 12.5-mg/kg lipopolysaccharide (LPS). Septic animals in the experimental group underwent RIC at 0, 2, and 6 h after LPS by surgical exploration and alternate clamping of the femoral artery. Six 4-min cycles of ischemia-reperfusion were performed. Primary outcome was survival at 5-d after LPS injection. Secondary outcome was to assess the following serum cytokine levels: interferon-γ (IFN-γ), interleukin (IL)-10, IL-1β, and tumor necrosis factoralpha (TNFα) at the baseline before LPS injection, 0 hour after LPS injection, and at 2, 4, 24 hours after induction of sepsis (RIC was performed at 2 h after LPS injection). Kaplan-Meier survival analysis and log-rank test were used. ANOVA test was used to compare cytokine measurements. We performed experiments on 44 mice: 14 sham and 30 RIC mice (10 at each time point). Overall survival was higher in the experimental group compared to the sham group (57% versus 21%; P = 0.02), with the highest survival rate observed in the 2-hour post-RIC group (70%). On Kaplan-Meier analysis, 2-h post-RIC group had increased survival at 5 days after LPS (P = 0.04) with hazard ratio of 0.3 (95% confidence interval = 0.09-0.98). In the RIC group, serum concentrations of IFN-γ, IL-10, IL-1β, and TNFα peaked at 2 h after LPS and then decreased significantly over 24 hours (P sepsis and has the potential for implementation in the clinical practice. Early implementation of RIC may play an

TBC-8, a Putative RAB-2 GAP, Regulates Dense Core Vesicle Maturation in Caenorhabditis elegans

Science.gov (United States)

Hannemann, Mandy; Sasidharan, Nikhil; Hegermann, Jan; Kutscher, Lena M.; Koenig, Sabine; Eimer, Stefan

2012-01-01

Dense core vesicles (DCVs) are thought to be generated at the late Golgi apparatus as immature DCVs, which subsequently undergo a maturation process through clathrin-mediated membrane remodeling events. This maturation process is required for efficient processing of neuropeptides within DCVs and for removal of factors that would otherwise interfere with DCV release. Previously, we have shown that the GTPase, RAB-2, and its effector, RIC-19, are involved in DCV maturation in Caenorhabditis elegans motoneurons. In rab-2 mutants, specific cargo is lost from maturing DCVs and missorted into the endosomal/lysosomal degradation route. Cargo loss could be prevented by blocking endosomal delivery. This suggests that RAB-2 is involved in retention of DCV components during the sorting process at the Golgi-endosomal interface. To understand how RAB-2 activity is regulated at the Golgi, we screened for RAB-2–specific GTPase activating proteins (GAPs). We identified a potential RAB-2 GAP, TBC-8, which is exclusively expressed in neurons and which, when depleted, shows similar DCV maturation defects as rab-2 mutants. We could demonstrate that RAB-2 binds to its putative GAP, TBC-8. Interestingly, TBC-8 also binds to the RAB-2 effector, RIC-19. This interaction appears to be conserved as TBC-8 also interacted with the human ortholog of RIC-19, ICA69. Therefore, we propose that a dynamic ON/OFF cycling of RAB-2 at the Golgi induced by the GAP/effector complex is required for proper DCV maturation. PMID:22654674

TBC-8, a putative RAB-2 GAP, regulates dense core vesicle maturation in Caenorhabditis elegans.

Directory of Open Access Journals (Sweden)

Mandy Hannemann

Full Text Available Dense core vesicles (DCVs are thought to be generated at the late Golgi apparatus as immature DCVs, which subsequently undergo a maturation process through clathrin-mediated membrane remodeling events. This maturation process is required for efficient processing of neuropeptides within DCVs and for removal of factors that would otherwise interfere with DCV release. Previously, we have shown that the GTPase, RAB-2, and its effector, RIC-19, are involved in DCV maturation in Caenorhabditis elegans motoneurons. In rab-2 mutants, specific cargo is lost from maturing DCVs and missorted into the endosomal/lysosomal degradation route. Cargo loss could be prevented by blocking endosomal delivery. This suggests that RAB-2 is involved in retention of DCV components during the sorting process at the Golgi-endosomal interface. To understand how RAB-2 activity is regulated at the Golgi, we screened for RAB-2-specific GTPase activating proteins (GAPs. We identified a potential RAB-2 GAP, TBC-8, which is exclusively expressed in neurons and which, when depleted, shows similar DCV maturation defects as rab-2 mutants. We could demonstrate that RAB-2 binds to its putative GAP, TBC-8. Interestingly, TBC-8 also binds to the RAB-2 effector, RIC-19. This interaction appears to be conserved as TBC-8 also interacted with the human ortholog of RIC-19, ICA69. Therefore, we propose that a dynamic ON/OFF cycling of RAB-2 at the Golgi induced by the GAP/effector complex is required for proper DCV maturation.

Retrospective audit of the investigation of patients with suspected acute subarachnoid haemorrhage

International Nuclear Information System (INIS)

Muhammed, O.; Teubnet, D.; Jones, D.N.; Slavotinek, J.P.

2010-01-01

Recommended investigational care (RIC) of emergency department (ED) patients with suspected subarachnoid haemorrhage comprises lumbar puncture (LP) to detect xanthochromia if the preceding CT scan is negative. Retrospective audit of the investigational care of 100 consecutive ED patients presenting with possible subarachnoid haemorrhage. Of the 100 patients, 91 had negative CT, and 36 (39.6%) of these patients had an LP performed to detect xanthochromia (i.e. RIC). Fifty-five of 91 (60.4%) patients did not receive RIC. Of the 55 patients who did not receive RIC, 25 (45.5%) had a documented senior clinical decision not to perform an LP; 15 (27.3%) had no documented reason; five (9.1%) refused consent; two (3.6%) had an LP but no xanthochromia requested, one patient did not have an LP because of technical issues, six patients underwent CT angiography (CTA), and one patient underwent magnetic resonance angiography (MRA), in the absence of a LP, following a negative CT. Two patients underwent CTA following a negative xanthochromia result. Patients admitted to the emergency extended care unit had 6.85 times the odds of receiving RIC (95% CI 2.20-21.4). Fifty-five (55) of 91 (60%) ED patients did not receive RIC. Fifteen of the 55 did not have any documented justification for not performing an LP with xanthochromia testing. Admission to an emergency extended care unit was a predictor of receiving RIC. Inappropriate use of CTA and MRA was identified. These findings have important implications for patient safety. Multifaceted strategies are required to close this evidence-practice gap.

The Process of Adjustment Among Caregivers of Individuals with Spinal Cord Injury: A Qualitative Study

Science.gov (United States)

2016-10-01

Analyze Data; Ongoing • Code qualitative data collected during initial interviews , developing codebooks based on the first few interviews , with...changes made as needed during the coding of subsequent initial interviews (months 5-16); Progress ongoing • Code qualitative data collected during follow...Schwab, RIC, and Hines. To date, 28 participants at Shriners have been consented , and we have completed 28 participant interviews , surpassing our

The diagnosis of cerebrospinal fluid hypovolemia. The comparison between CT myelography and RI cisternography

International Nuclear Information System (INIS)

Watanabe, Keisuke; Hashizume, Keiji; Inoue, Satoki; Fujiwara, Aki; Furuya, Hitoshi

2008-01-01

The comparison in the title is performed in cases with suspicious hypovolemia of cerebrospinal fluid (CSF) and its leak at the lumbar region is also examined in whiplash injury. Subjects are 25 cases (M 14/F 11, av. age 36.9 y) with traffic (13 cases), whiplash (4) and null (8) injuries. CT myelography (CTM) is conducted by injection of iotrolan through the lumbar puncturing needle to get 700 images of the whole spine of 1 mm slice thickness, which after animated, are observed visually. RI cisternography (RIC) is done immediately, 2 and 24 hr after injection of 10 MBq of diethylenetriamine pentaacetic acid (DTPA)-In through the puncturing needle. In 15 cases exhibiting positive RIC findings, CTM gives a positive leak at cervical and thoracic regions only in 2 cases and a false positive in other 13. In contrast, RIC fails to detect 2 cases of 4 with a leak at cervical and thoracic regions. Thus RIC is less reliable, and often observable RI accumulation at the lumbar area in RIC is not always a leak. (R.T.)

Reduced intensity versus full myeloablative stem cell transplant for advanced CLL.

Science.gov (United States)

Peres, E; Braun, T; Krijanovski, O; Khaled, Y; Levine, J E; Yanik, G; Kato, K; Mineishi, S

2009-11-01

CLL remains incurable with the standard therapy. Allogeneic hematopoietic stem cell transplant may be curative. We examined 50 patients with advanced CLL who underwent allogeneic HCT at the University of Michigan between 1996 and 2006. Twenty-one patients received reduced-intensity conditioning (RIC) and twenty-nine patients received full-intensity conditioning (FIC) consisting of CY, etoposide and BCNU (n=20) or BU and CY (n=9). RIC recipients were older than FIC recipients (median age 54 vs 51, P=0.009). There were no statistically significant differences between groups in terms of the number of earlier therapies or patients with adverse cytogenetics. There were more unrelated donors in the RIC group 62% than in the FIC group 31% (P=0.030). Despite their older age and greater use of URD, the 5-year overall survival (OS) rate was 63% in the RIC group as compared with 18% in the FIC group (P=0.006). The primary cause of inferior survival in the FIC recipients was TRM, which was twice as high at day 100 for the FIC group 27% compared with the RIC group 14% (P=0.005). The relapse rate was 15% regardless with the majority of relapses occurring after day 100. These results suggest a favorable outcome for advanced CLL who undergo a RIC regimen compared with FIC.

76 FR 5501 - Request for Comments: Review and Improvement of EDA's Regulations

Science.gov (United States)

2011-02-01

... creation and growth of Regional Innovation Clusters (RICs). In addition, EDA has identified potential... our stakeholders and the American people. 1. Regional Innovation Clusters (RICs) EDA supports the..., February 1, 2011 / Proposed Rules#0;#0; [[Page 5501

64Cu-Labeled Trastuzumab Fab-PEG24-EGF Radioimmunoconjugates Bispecific for HER2 and EGFR: Pharmacokinetics, Biodistribution, and Tumor Imaging by PET in Comparison to Monospecific Agents.

Science.gov (United States)

Kwon, Luke Yongkyu; Scollard, Deborah A; Reilly, Raymond M

2017-02-06

Heterodimerization of EGFR with HER2 coexpressed in breast cancer (BC) promotes tumor growth, and increased EGFR expression is associated with trastuzumab resistance. Our aim was to construct 64 Cu-labeled bispecific radioimmunoconjugates (bsRIC) composed of trastuzumab Fab, which binds HER2 linked through a polyethylene glycol (PEG 24 ) spacer to EGF, and to compare their pharmacokinetic, biodistribution, and tumor imaging characteristics by positron-emission tomography (PET). bsRICs were generated by linking maleimide modified trastuzumab Fab with thiolated EGF through a thioether bond. HER2 and EGFR binding were assessed in vitro in MDA-MB-231 (EGFR mod /HER2 low ), MDA-MB-468 (EGFR high /HER2 neg ), MDA-MB-231-H2N (EGFR mod /HER2 mod ), and SKOV3 (EGFR low /HER2 high ) cells by competition and saturation cell binding assays to estimate the dissociation constant (K d ). The elimination of the 64 Cu-NOTA-trastuzumab Fab-PEG 24 -EGF bsRICs from the blood of Balb/c mice was compared to monospecific 64 Cu-NOTA-trastuzumab Fab and 64 Cu-NOTA-EGF. MicroPET/CT imaging was performed in NOD/SCID mice bearing subcutaneous MDA-MB-468, MDA-MB-231/H2N, or SKOV3 human BC xenografts at 24 and 48 h postinjection (p.i.) of bsRICs. Tumor and normal tissue uptake were quantified by biodistribution studies and compared to monospecific agents. The binding of bsRICs to MDA-MB-231 cells was decreased to 24.5 ± 5.2% by excess EGF, while the binding of bsRICs to SKOV3 cells was decreased to 38.6 ± 5.4% by excess trastuzumab Fab, demonstrating specific binding to both EGFR and HER2. 64 Cu-labeled bsRICs incorporating the PEG 24 spacer were eliminated more slowly from the blood than 64 Cu-bsRICs without the PEG spacer and were cleared much more slowly than 64 Cu-NOTA-Fab or 64 Cu-NOTA-EGF. All three tumor xenografts were visualized by microPET/CT at 24 and 48 h p.i. of bsRICs. Biodistribution studies at 48 h p.i. in NOD/SCID mice with MDA-MB-231/H2N tumors demonstrated significantly

A voltage-gated pore for translocation of tRNA

Energy Technology Data Exchange (ETDEWEB)

Koley, Sandip; Adhya, Samit, E-mail: nilugrandson@gmail.com

2013-09-13

Highlights: •A tRNA translocating complex was assembled from purified proteins. •The complex translocates tRNA at a membrane potential of ∼60 mV. •Translocation requires Cys and His residues in the Fe–S center of RIC6 subunit. -- Abstract: Very little is known about how nucleic acids are translocated across membranes. The multi-subunit RNA Import Complex (RIC) from mitochondria of the kinetoplastid protozoon Leishmania tropica induces translocation of tRNAs across artificial or natural membranes, but the nature of the translocation pore remains unknown. We show that subunits RIC6 and RIC9 assemble on the membrane in presence of subunit RIC4A to form complex R3. Atomic Force Microscopy of R3 revealed particles with an asymmetric surface groove of ∼20 nm rim diameter and ∼1 nm depth. R3 induced translocation of tRNA into liposomes when the pH of the medium was lowered to ∼6 in the absence of ATP. R3-mediated tRNA translocation could also be induced at neutral pH by a K{sup +} diffusion potential with an optimum of 60–70 mV. Point mutations in the Cys{sub 2}–His{sub 2} Fe-binding motif of RIC6, which is homologous to the respiratory Complex III Fe–S protein, abrogated import induced by low pH but not by K{sup +} diffusion potential. These results indicate that the R3 complex forms a pore that is gated by a proton-generated membrane potential and that the Fe–S binding region of RIC6 has a role in proton translocation. The tRNA import complex of L. tropica thus contains a novel macromolecular channel distinct from the mitochondrial protein import pore that is apparently involved in tRNA import in some species.

Mapping Point-of-Purchase Influencers of Food Choice in Australian Remote Indigenous Communities

Directory of Open Access Journals (Sweden)

Joanna Henryks

2016-02-01

Full Text Available Closing the health gap between Indigenous and non-Indigenous Australians relies, in part, on addressing the poor levels of nutrition in remote Indigenous communities (RIC. This article identifies and maps key influencers of food choice at the point-of-purchase (POP in Australian RIC and identifies gaps in our knowledge. It is based on a narrative review of the literature pertaining to food in RIC from a range of disciplinary perspectives including nutrition, ethnography, public health, anthropology, and remote health to map POP drivers of food choice. In particular, the role of habit is identified as a key factor that has previously not been discussed in the literature. The conceptual framework can be used as a basis for future POP research in RIC and provides guidance for social marketers, public health, nutrition, and policy workers operating in this field.

Mobilized peripheral blood stem cells compared with bone marrow from HLA-identical siblings for reduced-intensity conditioning transplantation in acute myeloid leukemia in complete remission

DEFF Research Database (Denmark)

Nagler, Arnon; Labopin, Myriam; Shimoni, Avichai

2012-01-01

Reduced-intensity conditioning (RIC)-alloSCT is increasingly used for acute myelogenous leukemia. Limited data are available for the comparison of peripheral blood stem cells with bone marrow for RIC-alloSCT. We used the European Group for Blood and Marrow Transplantation (EBMT) ALWP data...... to compare the outcome of mobilized peripheral blood stem cells (PBSC) (n = 1430) vs. bone marrow (BM) (n = 107) for acute myelogenous leukemia (AML) patients with complete remission that underwent RIC-alloSCT from compatible sibling donors. The leukemia features, the disease status, and the time from...

Reduced-intensity conditioning lowers treatment-related mortality of allogeneic stem cell transplantation for chronic lymphocytic leukemia : a population-matched analysis

NARCIS (Netherlands)

Dreger, P; Brand, R; Milligan, D; Corradini, P; Finke, J; Deliliers, GL; Martino, R; Russell, N; van Biezen, A; Michallet, M; Niederwieser, D

To elucidate whether reduced-intensity conditioning (RIC) decreases treatment-related mortality (TRM) after allogeneic stem cell transplantation (allo-SCT) for chronic lymphocytic leukemia (CLL), we retrospectively compared 73 RIC cases from a recent EBMT survey with 82 patients from the EBMT

78 FR 64293 - Proposed Collection; Comment Request

Science.gov (United States)

2013-10-28

... Investment Companies. OMB Number: 1545-1010. Form Number: 1120-RIC. Abstract: Internal Revenue Code sections... DEPARTMENT OF THE TREASURY Internal Revenue Service [Form 1120-RIC] Proposed Collection; Comment Request AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments. SUMMARY...

76 FR 76491 - Economic Development Administration Regulatory Revision

Science.gov (United States)

2011-12-07

... Regional Innovation Clusters or RICs to define this important economic development strategy. See proposed... definition to emphasize vertical integration while remaining flexible by defining RICs as ``networks of... Vol. 76 Wednesday, No. 235 December 7, 2011 Part II Department of Commerce Economic Development...

Controls on Turbulent Mixing in a Strongly Stratified and Sheared Tidal River Plume

Energy Technology Data Exchange (ETDEWEB)

Jurisa, Joseph T.; Nash, Jonathan D.; Moum, James N.; Kilcher, Levi F.

2016-08-01

Considerable effort has been made to parameterize turbulent kinetic energy (TKE) dissipation rate ..epsilon.. and mixing in buoyant plumes and stratified shear flows. Here, a parameterization based on Kunze et al. is examined, which estimates ..epsilon.. as the amount of energy contained in an unstable shear layer (Ri < Ric) that must be dissipated to increase the Richardson number Ri = N2/S2 to a critical value Ric within a turbulent decay time scale. Observations from the tidal Columbia River plume are used to quantitatively assess the relevant parameters controlling ..epsilon.. over a range of tidal and river discharge forcings. Observed ..epsilon.. is found to be characterized by Kunze et al.'s form within a factor of 2, while exhibiting slightly decreased skill near Ri = Ric. Observed dissipation rates are compared to estimates from a constant interfacial drag formulation that neglects the direct effects of stratification. This is found to be appropriate in energetic regimes when the bulk-averaged Richardson number Rib is less than Ric/4. However, when Rib > Ric/4, the effects of stratification must be included. Similarly, ..epsilon.. scaled by the bulk velocity and density differences over the plume displays a clear dependence on Rib, decreasing as Rib approaches Ric. The Kunze et al. ..epsilon.. parameterization is modified to form an expression for the nondimensional dissipation rate that is solely a function of Rib, displaying good agreement with the observations. It is suggested that this formulation is broadly applicable for unstable to marginally unstable stratified shear flows.

Novel vaccination approach for dengue infection based on recombinant immune complex universal platform.

Science.gov (United States)

Kim, Mi-Young; Reljic, Rajko; Kilbourne, Jacquelyn; Ceballos-Olvera, Ivonne; Yang, Moon-Sik; Reyes-del Valle, Jorge; Mason, Hugh S

2015-04-08

Dengue infection is on the rise in many endemic areas of the tropics. Vaccination remains the most realistic strategy for prevention of this potentially fatal viral disease but there is currently no effective vaccine that could protect against all four known serotypes of the dengue virus. This study describes the generation and testing of a novel vaccination approach against dengue based on recombinant immune complexes (RIC). We modelled the dengue RIC on the existing Ebola RIC (Phoolcharoen, et al. Proc Natl Acad Sci USA 2011;108(Dec (51)):20695) but with a key modification that allowed formation of a universal RIC platform that can be easily adapted for use for other pathogens. This was achieved by retaining only the binding epitope of the 6D8 ant-Ebola mAb, which was then fused to the consensus dengue E3 domain (cEDIII), resulting in a hybrid dengue-Ebola RIC (DERIC). We expressed human and mouse versions of these molecules in tobacco plants using a geminivirus-based expression system. Following purification from the plant extracts by protein G affinity chromatography, DERIC bound to C1q component of complement, thus confirming functionality. Importantly, following immunization of mice, DERIC induced a potent, virus-neutralizing anti-cEDIII humoral immune response without exogenous adjuvants. We conclude that these self-adjuvanting immunogens have the potential to be developed as a novel vaccine candidate for dengue infection, and provide the basis for a universal RIC platform for use with other antigens. Copyright © 2015 Elsevier Ltd. All rights reserved.

The impact of center experience on results of reduced intensity:allogeneic hematopoietic SCT for AML. An analysis from the Acute Leukemia Working Party of the EBMT

DEFF Research Database (Denmark)

Giebel, S; Labopin, M; Mohty, M

2013-01-01

Allogeneic hematopoietic SCT with reduced-intensity conditioning (RIC-HSCT) is increasingly adopted for the treatment of older adults with AML. Our goal was to verify for the first time, if center experience influences outcome of RIC-HSCT. Results of 1413 transplantations from HLA-matched related...

Improved GFR and renal plasma perfusion following remote ischaemic conditioning in a porcine kidney transplantation model

DEFF Research Database (Denmark)

Krogstrup, Nicoline V; Soendergaard, Peter; Secher, Niels G

2012-01-01

Delayed graft function (DGF) complicates approximately 25% of kidney allografts donated after brain death (DBD). Remote ischaemic conditioning (rIC) involves brief, repetitive, ischaemia in a distant tissue in connection with ischaemia/reperfusion in the target organ. rIC has been shown to induce...

Modulation of the stretch reflex arc to improve functional recovery after peripheral nerve injury

OpenAIRE

Arbat i Plana, Ariadna

2016-01-01

Després d'una lesió del sistema nerviós perifèric, aquest té la capacitat de regenerar però la seva recuperació funcional sol ser limitada, principalment degut a la inespecificitat de la reinnervació dels òrgans perifèrics i als canvis plàstics maladaptatius de la circuiteria espinal. En aquesta tesi hem volgut modular els canvis a la circuiteria espinal del reflex d'estirament per poder millorar la recuperació funcional després de lesions del nervi perifèric en un model animal. En primer llo...

In vitro evaluation of resonance frequency analysis values to different implant contact ratio and stiffness of surrounding material.

Science.gov (United States)

Kwak, Mu-Seung; Kim, Seok-Gyu

2013-11-01

The present study was aimed to evaluate the influence of implant contact ratio and stiffness of implant-surrounding materials on the resonance frequency analysis (RFA) values. Seventy resin blocks that had the different amounts (100, 50, 30, 15%) of resin-implant contact (RIC) were fabricated. Ten silicone putty blocks with 100% silicone-implant contact were also made. The implants with Ø5.0 mm × 13.0 mm were placed on eighty specimen blocks. The RFA value was measured on the transducer that was connected to each implant by Osstell Mentor. Kruskal-Wallis and Scheffe's tests (α=.05) were done for statistical analysis. The control resin group with 100% RIC had the highest RFA value of 83.9, which was significantly different only from the resin group with 15% RIC among the resin groups. The silicone putty group with 100% contact had the lowest RFA value of 36.6 and showed statistically significant differences from the resin groups. Within the limitations of this in vitro study, there was no significant difference in the RFA values among the resin groups with different RIC's except when the RIC difference was more than 85%. A significant increase in the RFA value was observed related to the increase in stiffness of material around implant.

76 FR 12415 - Proposed Collection; Comment Request for Regulation Project

Science.gov (United States)

2011-03-07

..., Certain Transfers of Property to Regulated Investment Companies (RICs) and Real Estate Investment Trusts... Property to Regulated Investment Companies (RICs) and Real Estate Investment Trusts (REITs). OMB Number... with respect to the net built-in gain of C corporation property that becomes property of a Regulated...

La Inscripción Ibérica en escritura jonia, Serreta IX.

OpenAIRE

Silgo Gauche, Luís

1997-01-01

S’estudía una nova inscripció sobre làmina de plom, localitzada casualment en l’àrea del poblat ibèric de la Serreta (Alcoi, Cocentaina, Penàguila), en l’escriptura del qual es van emprar caracters greco-ibèrics.

Analysis of impulse oscillometric measures of lung function and respiratory system model parameters in small airway-impaired and healthy children over a 2-year period

Directory of Open Access Journals (Sweden)

Nava Pat

2011-03-01

Full Text Available Abstract Background Is Impulse Oscillometry System (IOS a valuable tool to measure respiratory system function in Children? Asthma (A is the most prevalent chronic respiratory disease in children. Therefore, early and accurate assessment of respiratory function is of tremendous clinical interest in diagnosis, monitoring and treatment of respiratory conditions in this subpopulation. IOS has been successfully used to measure lung function in children with a high degree of sensitivity and specificity to small airway impairments (SAI and asthma. IOS measures of airway function and equivalent electrical circuit models of the human respiratory system have been developed to quantify the severity of these conditions. Previously, we have evaluated several known respiratory models based on the Mead's model and more parsimonious versions based on fitting IOS data known as extended RIC (eRIC and augmented RIC (aRIC models have emerged, which offer advantages over earlier models. Methods IOS data from twenty-six children were collected and compared during pre-bronchodilation (pre-B and post- bronchodilation (post-B conditions over a period of 2 years. Results and Discussion Are the IOS and model parameters capable of differentiating between healthy children and children with respiratory system distress? Children were classified into two main categories: Healthy (H and Small Airway-Impaired (SAI. The IOS measures and respiratory model parameters analyzed differed consistently between H and SAI children. SAI children showed smaller trend of "growth" and larger trend of bronchodilator responses than H children. The two model parameters: peripheral compliance (Cp and peripheral resistance (Rp tracked IOS indices of small airway function well. Cp was a more sensitive index than Rp. Both eRIC and aRIC Cps and the IOS Reactance Area, AX, (also known as the "Goldman Triangle" showed good correlations. Conclusions What are the most useful IOS and model parameters? In

Reduced intensity-conditioned allogeneic stem cell transplantation for multiple myeloma relapsing or progressing after autologous transplantation: a study by the European Group for Blood and Marrow Transplantation.

NARCIS (Netherlands)

Auner, H.W.; Szydlo, R.; Biezen, A. van; Iacobelli, S.; Gahrton, G.; Milpied, N.; Volin, L.; Janssen, J.; Nguyen Quoc, S.; Michallet, M.; Schoemans, H.; Cheikh, J. El; Petersen, E.; Guilhot, F.; Schonland, S.; Ahlberg, L.; Morris, C.; Garderet, L.; Witte, T.J. de; Kroger, N.

2013-01-01

Outcomes and prognostic factors of reduced intensity-conditioned allo-SCT (RIC allo-SCT) for multiple myeloma (MM) relapsing or progressing after prior autologous (auto)-SCT are not well defined. We performed an analysis of 413 MM patients who received a related or unrelated RIC allo-SCT for the

Autologous or reduced-intensity conditioning allogeneic hematopoietic cell transplantation for chemotherapy-sensitive mantle-cell lymphoma: analysis of transplantation timing and modality.

Science.gov (United States)

Fenske, Timothy S; Zhang, Mei-Jie; Carreras, Jeanette; Ayala, Ernesto; Burns, Linda J; Cashen, Amanda; Costa, Luciano J; Freytes, César O; Gale, Robert P; Hamadani, Mehdi; Holmberg, Leona A; Inwards, David J; Lazarus, Hillard M; Maziarz, Richard T; Munker, Reinhold; Perales, Miguel-Angel; Rizzieri, David A; Schouten, Harry C; Smith, Sonali M; Waller, Edmund K; Wirk, Baldeep M; Laport, Ginna G; Maloney, David G; Montoto, Silvia; Hari, Parameswaran N

2014-02-01

To examine the outcomes of patients with chemotherapy-sensitive mantle-cell lymphoma (MCL) following a first hematopoietic stem-cell transplantation (HCT), comparing outcomes with autologous (auto) versus reduced-intensity conditioning allogeneic (RIC allo) HCT and with transplantation applied at different times in the disease course. In all, 519 patients who received transplantations between 1996 and 2007 and were reported to the Center for International Blood and Marrow Transplant Research were analyzed. The early transplantation cohort was defined as those patients in first partial or complete remission with no more than two lines of chemotherapy. The late transplantation cohort was defined as all the remaining patients. Auto-HCT and RIC allo-HCT resulted in similar overall survival from transplantation for both the early (at 5 years: 61% auto-HCT v 62% RIC allo-HCT; P = .951) and late cohorts (at 5 years: 44% auto-HCT v 31% RIC allo-HCT; P = .202). In both early and late transplantation cohorts, progression/relapse was lower and nonrelapse mortality was higher in the allo-HCT group. Overall survival and progression-free survival were highest in patients who underwent auto-HCT in first complete response. Multivariate analysis of survival from diagnosis identified a survival benefit favoring early HCT for both auto-HCT and RIC allo-HCT. For patients with chemotherapy-sensitive MCL, the optimal timing for HCT is early in the disease course. Outcomes are particularly favorable for patients undergoing auto-HCT in first complete remission. For those unable to achieve complete remission after two lines of chemotherapy or those with relapsed disease, either auto-HCT or RIC allo-HCT may be effective, although the chance for long-term remission and survival is lower.

Summary of round robin measurements of radiation induced conductivity in Wesgo AL995 alumina

Energy Technology Data Exchange (ETDEWEB)

Zinkle, S.J. [Oak Ridge National Lab., TN (United States)

1996-10-01

This existing data on radiation induced conductivity (RIC) measurements performed on the same heat of the IEA reference ceramic insulator are summarized. Six different sets of RIC measurements have been performed on Wesgo AL995 at dose rates between 10 Gy/s and 1 MGy/s. In general, good agreement was obtained between the different groups of researchers. The data indicate that the RIC at a test temperature of 400-500{degrees}C is approximately linear with ionizing dose rate up to {approximately}1000 Gy/s, and exhibits an approximately square root dependence on dose rate between 1 kGy/s and 1 MGy/s.

DNA-PK inhibition causes a low level of H2AX phosphorylation and homologous recombination repair in Medaka (Oryzias latipes) cells

International Nuclear Information System (INIS)

Urushihara, Yusuke; Kobayashi, Junya; Matsumoto, Yoshihisa; Komatsu, Kenshi; Oda, Shoji; Mitani, Hiroshi

2012-01-01

Highlights: ► We investigated the effect of DNA-PK inhibition on DSB repair using fish cells. ► A radiation sensitive mutant RIC1 strain showed a low level of DNA-PK activity. ► DNA-PK dysfunction leads defects in HR repair and DNA-PKcs autophosphorylation. ► DNA-PK dysfunction leads a slight increase in the number of 53BP1 foci after DSBs. ► DNA-PK dysfunction leads an alternative NHEJ that depends on 53BP1. -- Abstract: Nonhomologous end joining (NHEJ) and homologous recombination (HR) are known as DNA double-strand break (DSB) repair pathways. It has been reported that DNA-PK, a member of PI3 kinase family, promotes NHEJ and aberrant DNA-PK causes NHEJ deficiency. However, in this study, we demonstrate that a wild-type cell line treated with DNA-PK inhibitor and a mutant cell line with dysfunctional DNA-PK showed decreased HR efficiency in fish cells (Medaka, Oryzias latipes). Previously, we reported that the radiation-sensitive mutant RIC1 strain has a defect in the Histone H2AX phosphorylation after γ-irradiation. Here, we showed that a DNA-PK inhibitor, NU7026, treatment resulted in significant reduction in the number of γH2AX foci after γ-irradiation in wild-type cells, but had no significant effect in RIC1 cells. In addition, RIC1 cells showed significantly lower levels of DNA-PK kinase activity compared with wild-type cells. We investigated NHEJ and HR efficiency after induction of DSBs. Wild-type cells treated with NU7026 and RIC1 cells showed decreased HR efficiency. These results indicated that aberrant DNA-PK causes the reduction in the number of γH2AX foci and HR efficiency in RIC1 cells. We performed phosphorylated DNA-PKcs (Thr2609) and 53BP1 focus assay after γ-irradiation. RIC1 cells showed significant reduction in the number of phosphorylated DNA-PKcs foci and no deference in the number of 53BP1 foci compared with wild-type cells. These results suggest that low level of DNA-PK activity causes aberrant DNA-PKcs autophosphorylation

Reduced-intensity conditioning allogeneic SCT as salvage treatment for relapsed multiple myeloma.

Science.gov (United States)

de Lavallade, H; El-Cheikh, J; Faucher, C; Fürst, S; Stoppa, A-M; Coso, D; Bouabdallah, R; Chabannon, C; Gastaut, J-A; Blaise, D; Mohty, M

2008-06-01

The aim of this retrospective analysis was to assess the benefit of reduced-intensity conditioning allo SCT (RIC allo-SCT) in a cohort of 32 relapsed multiple myeloma (MM) patients. A total of 19 patients had an HLA-identical sibling donor ('donor' group), while 13 patients had no donor ('no-donor' group). There were no significant differences between these two groups as for prognosis risk factors. Eighteen patients from the 'donor' group could actually proceed to RIC allo-SCT. With a median follow-up of 36 (range, 21-60) months, six patients died from transplant-related toxicity (cumulative incidence, 33% (95% CI, 11-55%)). Only 4 patients from the 18 transplanted patients (22%; 95% CI, 7-48%) progressed after RIC allo-SCT, as compared to 12 (86%; 95% CI, 56-98%; P=0.0003) among the nontransplanted patients. In an 'intention-to-treat' analysis, the Kaplan-Meier estimate of PFS was significantly higher in the 'donor' group as compared to the 'no-donor' group (P=0.01; 46 versus 8% at 3 years). There was no difference in terms of overall survival. However, in multivariate analysis, actual performance of RIC allo-SCT was associated with better PFS (relative risk, 0.35; 95% CI, 0.15-0.82; P=0.01). These data suggest a potential benefit for RIC allo-SCT in the management of relapsed MM warranting further prospective investigations.

The Ambiguity of Justice: Paul Ricoeur on Universalism and Evil

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Geoffrey Dierckxsens

2016-01-01

Full Text Available In this article I will examine Ricœur’s idea of the universal in his understanding of justice. Scholars recently discussed the extent to which Ricœur understands universal moral norms and universal rules of justice in his anthropology of human action (e.g., J. Michel, Paul Ricœur: une philosophie de l’agir humain, Paris: Les Éditions du Cerf, 2006, and argue that Ricœur stresses too much the idea of universal moral norms with regard to cultural and moral diversity (e.g., G. H. Taylor, “Ricoeur versus Ricoeur? Between the Universal and the Contextual,” From Ricoeur to Action. The Socio-Political Significance of Ricoeur’s Thinking, Todd S. Mei and David Lewin (eds., (London and New York: Bloomsbury, 2012. G. H. Taylor, “Reenvisioning Justice,” Lo Squarda 12 (2013: 65-80. In this article I will take part in the debate about universalism and approach Ricœur’s idea of the universal from a different angle, in placing it in light of his idea of evil. The point I will aim to make in this article is that Ricœur’s idea of the relation between justice and evil demonstrates what I understand as the ambiguity of justice, which highlights the difficulty of defining universal rules of justice. I will argue that this ambiguity is the following: justice aims at the establishment of social peace and in that sense it is the necessary remedy against human evil, but justice also implies power, and possibly violence, over others in that it relates to violent feelings of vengeance, to institutional mechanism of authority, and to a struggle of values. Yet if rules of justice relate to evil in the sense of power over others, so I argue, then it is problematic to define absolute criteria for rules of justice, i.e., for rules for social peace: because justice relates to particular values, which means that the risk of violence is inherent to institutional rules of justice, there is no ultimate universal set of such rules. This article therefore

Remote Ischemic Conditioning and Renal Protection.

Science.gov (United States)

Giannopoulos, Georgios; Vrachatis, Dimitrios A; Panagopoulou, Vasiliki; Vavuranakis, Manolis; Cleman, Michael W; Deftereos, Spyridon

2017-07-01

Over the course of the last 2 decades, the concept of remote ischemic conditioning (RIC) has attracted considerable research interest, because RIC, in most of its embodiments offers an inexpensive way of protecting tissues against ischemic damage inflicted by a number of medical conditions or procedures. Acute kidney injury (AKI) is a common side effect in the context of various medical procedures, and RIC has been suggested as a means of reducing its incidence. Outcomes regarding kidney function have been reported in numerous studies that evaluated the effects of RIC in a variety of settings (eg, cardiac surgery, interventions requiring intravenous administration of contrast media). Although several individual studies have implied a beneficial effect of RIC in preserving kidney function, 3 recently published randomized controlled trials evaluating more than 1000 patients each (Effect of Remote Ischemic Preconditioning in the Cardiac Surgery, Remote Ischaemic Preconditioning for Heart Surgery, and ERICCA) were negative. However, AKI or any other index of renal function was not a stand-alone primary end point in any of these trials. On the other hand, a range of meta-analyses (each including thousands of participants) have reported mixed results, with the most recent among them showing benefit from RIC, pinpointing at the same time a number of shortcomings in published studies, adversely affecting the quality of available data. The present review provides a critical appraisal of the current state of this field of research. It is the opinion of the authors of this review that there is a clear need for a common clinical trial framework for ischemic conditioning studies. If the current babel of definitions, procedures, outcomes, and goals persists, it is most likely that soon ischemic conditioning will be "yesterday's news" with no definitive conclusions having been reached in terms of its real clinical utility.

26 CFR 1.1296-1 - Mark to market election for marketable stock.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Mark to market election for marketable stock. 1....1296-1 Mark to market election for marketable stock. (a) Definitions—(1) Eligible RIC. An eligible RIC... included in gross income by the company pursuant to such mark to market election with respect to such stock...

Russia and the BRICS:

DEFF Research Database (Denmark)

Skak, Mette

Russia's role as driver behind the BRICS is critically examined via the original RIC concept of Primakov. Today, there are mixed feelings about the BRICS in Russia.......Russia's role as driver behind the BRICS is critically examined via the original RIC concept of Primakov. Today, there are mixed feelings about the BRICS in Russia....

Argentina, de territoris a províncies: una mirada des de l'Estat, l'educació i la premsa (segles XIX i XX

Directory of Open Access Journals (Sweden)

Martha Ruffini

2016-05-01

Full Text Available El present dossier, divers pel que fa a les àrees geogràfiques i continguts, té com a objectiu mostrar un fil conductor comú, és a dir, descobrir processos històrics que van tenir lloc en espais considerats perifèrics o marginals dins el territori argentí.

0ric;inal. articles

African Journals Online (AJOL)

P ... dipstix urine is exaritined for glucose, protein and ketones; capillary blood ..... breadths) and function (grip strength of both hands and neuromuscular ... should take the form of improved diet, increased exercise, and plenty of time spent ...

The Convergence of Ricoeur’s and Von Wright’s Complex Models of History

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Linda L. Cox

2014-07-01

Full Text Available The relationship between the structural identity of narrative and the truth claim of the historical narrative work is one of importance to Ricœur. He considers the attempts of two interwoven models of history emerging from analytic philosophy—explanatory and narrative—to articulate this relationship. This paper explores the trajectories of these models as well as the epistemological and ontological crises culminating from the “simple” theses of each model. The solution to these crises requires a more complex method to account for the nature of the connections underlying historical understanding. Georg Henrik von Wright’s provisional or “hybrid” model of explanation and understanding revises the simple explanatory model and is foundational for Ricœur’s own complex revision of narrativist models through his notion of questioning back. The present paper argues that the structure of this hybrid model was unsatisfactory for von Wright, and leads in the direction of Ricœur’s own narrative method. Keywords: Ricœur, von Wright, Narrative, History, Questioning back. Résumé La relation entre l’identité structurale du récit et la prétention à la vérité de l’œuvre de récit historique est fondamentale chez Ricœur. Il considère que les deux modèles historiographiques de provenance analytique – le modèle explicatif et le modèle narratif – peuvent s’articuler. Cet article explore les trajectoires de ces modèles autant que les crises épistémologiques et ontologiques qui culminent dans chacune des thèses prise dans un sens unilatéral. La solution pour remédier à ces crises requiert une méthode plus complexe pour tenir compte de la nature des liens qui sous-tendent la compréhension historique. Le modèle d’explication et de compréhension, provisoire et “hybride,” de Georg Henrik von Wright permet de réviser le simple modèle explicatif. Ceci est fondamental pour comprendre  la révision complexe que

Fulltext PDF

Indian Academy of Sciences (India)

... Non-magnetic Chemically Peculiar. Stars as a Probe of Dynamical Processes in Stellar Interiors, 231. Vega Rodríguez Miguel A. see Gómez Pulido Juan A., 103. Zagury Frédéric Spectral Analysis of the Background in Ground-based,. Long-slit Spectroscopy, d0; An Analysis of Spectra in the Red Rectangle. Nebula, 377.

Some functional inequalities on non-reversible Finsler manifolds

Indian Academy of Sciences (India)

SHIN-ICHI OHTA

2017-11-13

Nov 13, 2017 ... In the reversible case, these inequalities were obtained by. Cavalletti and ... active area. The classical Riemannian theory has been generalized to weighted Rieman- .... Define the dual Minkowski norm F. ∗: T. ∗ .... We also define Ric∞(v) and Ricn(v) as the limits and set RicN (cv) := c2RicN (v) for c ≥ 0.

High treatment efficacy by dual targeting of Burkitt's lymphoma xenografted mice with a {sup 177}Lu-based CD22-specific radioimmunoconjugate and rituximab

Energy Technology Data Exchange (ETDEWEB)

Weber, Tobias; Boetticher, Benedikt; Keller, Armin; Schlegelmilch, Anne; Jaeger, Dirk; Krauss, Juergen [Heidelberg University Hospital, Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg (Germany); Mier, Walter; Kraemer, Susanne; Leotta, Karin [Heidelberg University Hospital, Department of Nuclear Medicine, Heidelberg (Germany); Sauter, Max; Haberkorn, Uwe [Heidelberg University Hospital, Department of Nuclear Medicine, Heidelberg (Germany); German Cancer Research Center (DKFZ), Clinical Cooperation Unit Nuclear Medicine, Heidelberg (Germany); Grosse-Hovest, Ludger [University of Tuebingen, Department of Immunology, Tuebingen (Germany); Arndt, Michaela A.E. [Heidelberg University Hospital, Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg (Germany); German Cancer Research Center (DKFZ), Immunotherapy Program, National Center for Tumor Diseases, Heidelberg (Germany)

2016-03-15

Dual-targeted therapy has been shown to be a promising treatment option in recurrent and/or refractory B-cell non-Hodgkin's lymphoma (B-NHL). We generated radioimmunoconjugates (RICs) comprising either a novel humanized anti-CD22 monoclonal antibody, huRFB4, or rituximab, and the low-energy β-emitter {sup 177}Lu. Both RICs were evaluated as single agents in a human Burkitt's lymphoma xenograft mouse model. To increase the therapeutic efficacy of the anti-CD22 RIC, combination therapy with unlabelled anti-CD20 rituximab was explored. The binding activity of CHX-A''-DTPA-conjugated antibodies to target cells was analysed by flow cytometry. To assess tumour targeting of {sup 177}Lu-labelled antibodies, in vivo biodistribution experiments were performed. For radioimmunotherapy (RIT) studies, non-obese diabetic recombination activating gene-1 (NOD-Rag1{sup null}) interleukin-2 receptor common gamma chain (IL2r γ {sup null}) null mice (NRG mice) were xenografted subcutaneously with Raji Burkitt's lymphoma cells. {sup 177}Lu-conjugated antibodies were administered at a single dose of 9.5 MBq per mouse. For dual-targeted therapy, rituximab was injected at weekly intervals (0.5 - 1.0 mg). Tumour accumulation of RICs was monitored by planar scintigraphy. Conjugation of CHX-A''-DTPA resulted in highly stable RICs with excellent antigen-binding properties. Biodistribution experiments revealed higher tumour uptake of the {sup 177}Lu-labelled anti-CD22 IgG than of {sup 177}Lu-labelled rituximab. Treatment with {sup 177}Lu-conjugated huRFB4 resulted in increased tumour growth inhibition and significantly longer survival than treatment with {sup 177}Lu-conjugated rituximab. The therapeutic efficacy of the anti-CD22 RIC could be markedly enhanced by combination with unlabelled rituximab. These findings suggest that dual targeting with {sup 177}Lu-based CD22-specific RIT in combination with rituximab is a promising new treatment option for

Quelles pratiques sémiotiques pour quelles médiations ?

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Anne Hénault

2017-06-01

ABSTRACT: In January 1963, Paul Ricœur was very interested in structuralism to which he had already devoted important readings (Rome, Entretiens Castelli. In June 1963, during a heated debate with C. Levi-Strauss, under the Esprit Journal, Ricœur developed a violent rejection of structural thought, and his resentment will endure until his last work, devoted to History, in 2002. Initially (up to 1979, this anathema was also aimed at A. J. Greimas and his semiotics. Then, following a series of university meetings and public debates with Greimas, Ricœur came to a complete change of view of Greimas's works, to the point of intimacy, at the last public debate between them (In 1989, not to use the pretext of his research on the semiotics of the passions to distance himself from his first semiotics (that which from the Sémantique structurale to the Dictionnaire comes to be known as "standard semiotics". After this, Ricœur explicitly formulated the idea that standard semiotics had elaborated a new rationality, the explanatory power of which was authentically "theoretical" and therefore scientific, which led him to admit that the semiotic explanation could be revealed necessary even in the field of Hermeneutics, in order to reach a more exact level of understanding.

Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options

Science.gov (United States)

Chen, Gangling; Thakkar, Mrugesh; Robinson, Christopher; Doré, Sylvain

2018-01-01

Novel and innovative approaches are essential in developing new treatments and improving clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a series of mechanical interruptions in blood flow of a distal organ, following end organ reperfusion, shown to significantly reduce infarct size through inhibition of oxidation and inflammation. Ischemia/reperfusion (I/R) is what ultimately leads to the irreversible brain damage and clinical picture seen in stroke patients. There have been several reports and reviews about the potential of RIC in acute ischemic stroke; however, the focus here is a comprehensive look at the differences in the three types of RIC (remote pre-, per-, and postconditioning). There are some limited uses of preconditioning in acute ischemic stroke due to the unpredictability of the ischemic event; however, it does provide the identification of biomarkers for clinical studies. Remote limb per- and postconditioning offer a more promising treatment during patient care as they can be harnessed during or after the initial ischemic insult. Though further research is needed, it is imperative to discuss the importance of preclinical data in understanding the methods and mechanisms involved in RIC. This understanding will facilitate translation to a clinically feasible paradigm for use in the hospital setting. PMID:29467715

Automated refueling inventory control system at FFTF

International Nuclear Information System (INIS)

Ordonez, C.R.

1983-10-01

The Refueling Inventory Control System (RICS) at the Fast Flux Test Facility (FFTF) keeps track of all assemblies that reside in the various refueling facilities. The automated RICS allows the user to obtain information regarding any assembly under its control by displaying the data on a screen. It also provides a simulation mode which allows assembly moves on a duplicated data base. This simulation is used to verify the refueling documentation before it is issued

Événement, idéologie et utopie

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Jean-Luc AMALRIC

2014-12-01

Full Text Available RESUMEL’hypothèse que tente d’esquisser cet article est que l’idée ricœurienne d’une médiatisation dynamique des contradictions de l’imaginaire social présuppose une corrélation originaire de l’idéologie et de l’utopie qui ne peut elle-même être comprise qu’à partir de l’événement de l’institution d’un imaginaire social constituant. Dans un premier temps, l’article s’efforce de cerner ce qui fait la spécificité de la théorie ricœurienne de l’idéologie et de l’utopie comme « pratiques imaginatives », en soulignant à ce titre l’influence déterminante des thèses de Jacques Ellul sur l’idéologie. Puis, dans un second temps, il s’engage dans une analyse régressive qui conduit de la réappropriation ricœurienne de la conception dialectique de l’idéologie et de l’utopie exposée par Mannheim à l’idée d’un fondement événementiel de ces deux formes opposées de l’imaginaire social.Mots-Clés : Evénement, idéologie, utopie, Ellul, Mannheim. ABSTRACTThis paper attempts to sketch out the hypothesis that the Ricœurian conception of a dynamic mediatization of the contradictions of the social imaginary presupposes an original correlation between ideology and utopia, which can itself be understood only from the event that institutes a constitutive social imaginary. The first part of the paper marks out the specificity of the Ricœurian theory of ideology and utopia in terms of “imaginative practices”, underlining the determining influence of Jacques Ellul’s theses on ideology. The second part tries to develop a regressive argument, starting from the Ricœurian re-appropriation of Mannheim’s dialectical conception of ideology and utopia, and leading back to the idea of an event foundation for these two opposed forms of the social imaginary.Keywords : Event, Ideology, Utopia, Ellul, Mannheim   

High Concentrations of Measles Neutralizing Antibodies and High-Avidity Measles IgG Accurately Identify Measles Reinfection Cases

Science.gov (United States)

Rota, Jennifer S.; Hickman, Carole J.; Mercader, Sara; Redd, Susan; McNall, Rebecca J.; Williams, Nobia; McGrew, Marcia; Walls, M. Laura; Rota, Paul A.; Bellini, William J.

2016-01-01

In the United States, approximately 9% of the measles cases reported from 2012 to 2014 occurred in vaccinated individuals. Laboratory confirmation of measles in vaccinated individuals is challenging since IgM assays can give inconclusive results. Although a positive reverse transcription (RT)-PCR assay result from an appropriately timed specimen can provide confirmation, negative results may not rule out a highly suspicious case. Detection of high-avidity measles IgG in serum samples provides laboratory evidence of a past immunologic response to measles from natural infection or immunization. High concentrations of measles neutralizing antibody have been observed by plaque reduction neutralization (PRN) assays among confirmed measles cases with high-avidity IgG, referred to here as reinfection cases (RICs). In this study, we evaluated the utility of measuring levels of measles neutralizing antibody to distinguish RICs from noncases by receiver operating characteristic curve analysis. Single and paired serum samples with high-avidity measles IgG from suspected measles cases submitted to the CDC for routine surveillance were used for the analysis. The RICs were confirmed by a 4-fold rise in PRN titer or by RT-quantitative PCR (RT-qPCR) assay, while the noncases were negative by both assays. Discrimination accuracy was high with serum samples collected ≥3 days after rash onset (area under the curve, 0.953; 95% confidence interval [CI], 0.854 to 0.993). Measles neutralizing antibody concentrations of ≥40,000 mIU/ml identified RICs with 90% sensitivity (95% CI, 74 to 98%) and 100% specificity (95% CI, 82 to 100%). Therefore, when serological or RT-qPCR results are unavailable or inconclusive, suspected measles cases with high-avidity measles IgG can be confirmed as RICs by measles neutralizing antibody concentrations of ≥40,000 mIU/ml. PMID:27335386

Les ruines à l'épreuve de La mémoire, l'histoire, l'oubli: Imaginer se souvenir?

Directory of Open Access Journals (Sweden)

Laure Barillas

2017-07-01

Full Text Available What place should be given to ruins in the phenomenology of memory sketched by Ricœur in Memory, History, Forgetting? The contemplation of ruins raises the same problem as that which occupies the whole of Ricœur’s work: the representation of the past and the relations of memory and imagination in the formation of recollection. Can ruins give rise to a rearrangement of the relations of memory and imagination and produce an “imagining remembering”?

EVOLUTION DU CONCEPT DE LA QUALITE DE VIE AU MAROC : CAS DE LA POLYARTHRITE RHUMATOÏDE ET DE LA SPONDYLOARTHRITE ANKYLOSANTE

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Hanan RKAIN

2017-05-01

Full Text Available La polyarthrite rhumatoïde et la spondylarthrite ankylosante sont à la tête des rhumatismes inflammatoires chroniques (RIC. La souffrance engendrée par la douleur chronique rhumatismale, le retentissement sur le vécu journalier des patients et leur entourage, altèrent incontestablement la qualité de vie des patients. Ce travail reprend de manière succincte les études ayant abordé cet aspect chez les patients marocains souffrant de PR et de SPA. Ces travaux font l’unanimité sur la perturbation de la qualité de vie des patients marocains souffrant de ces RIC en affectant considérablement les domaines physique, psychique et social. Les études longitudinales, réalisées en particulier dans la PR, attestent de l’intérêt de la prise en charge adéquate de ces RIC pour améliorer la qualité de vie du patient marocain.

Should elderly patients with higher-risk myelodysplastic syndromes undergo allogeneic hematopoietic stem cell transplantation?

Science.gov (United States)

Zeidan, Amer M; Gore, Steven D

2013-10-01

Myelodysplastic syndromes (MDS) include a group of hematopoietic malignancies characterized by dysplastic changes, ineffective hematopoiesis and variable risk of leukemic progression. At diagnosis, 86% of MDS patients are ≥60 years. Azacitidine, the only drug that prolongs life in high-risk (HR)-MDS patients, adds a median of only 9.5 months to life. Allogeneic stem cell transplantation (alloSCT) remains the only potentially curative approach. Despite recent improvements including use of reduced intensity conditioning (RIC) that decrease transplant-related mortality, alloSCT continues to be used rarely in elderly MDS. There is paucity of data regarding outcomes of RIC alloSCT in elderly MDS patients, especially in direct comparison with azanucleosides. In this paper, the authors discuss the recent Markov decision analysis by Koreth et al. in which investigators demonstrated superior survival of patients with HR-MDS aged 60-70 years who underwent RIC alloSCT in comparison with those who were treated with azanucleosides.

Psychiatric Symptoms and Barriers to Care in HIV-Infected Individuals Who Are Lost to Care.

Science.gov (United States)

McLean, Carmen P; Gay, Natalie G; Metzger, David A; Foa, Edna B

Past studies of barriers to HIV care have not comprehensively assessed psychiatric symptoms, and few have assessed barriers to care among people living with HIV (PLWH) who are lost to care (LTC). We examined psychiatric symptoms, barriers to HIV care, and immune functioning in PLWH who were retained in care (RIC; n = 21) or LTC (n = 21). Participants completed diagnostic interviews for posttraumatic stress disorder (PTSD) and other psychiatric disorders, self-report measures of HIV risk behaviors and psychiatric symptoms, and a blood draw to assess viral load. Compared to RIC participants, LTC participants met criteria for a greater number of psychiatric disorders and reported greater depressive symptoms and more barriers to HIV care. There were no group differences in PTSD severity, risk behaviors, or viral load, suggesting that LTC individuals experience greater psychiatric problems and perceive more barriers to care than RIC participants, but are not less likely to have achieved viral suppression.

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

DEFF Research Database (Denmark)

Kleinert, Maximilian; Parker, Benjamin L; Chaudhuri, Rima

2016-01-01

culture. RESULTS: Ric mKO mice exhibited a greater reliance on fat as an energy substrate, a re-partitioning of lean to fat mass and an increase in intramyocellular triglyceride (IMTG) content, along with increases in several lipid metabolites in muscle. Unbiased proteomics revealed an increase......OBJECTIVE: We have recently shown that acute inhibition of both mTOR complexes (mTORC1 and mTORC2) increases whole-body lipid utilization, while mTORC1 inhibition had no effect. Therefore, we tested the hypothesis that mTORC2 regulates lipid metabolism in skeletal muscle. METHODS: Body composition...... in the expression of the lipid droplet binding protein Perilipin 3 (PLIN3) in muscle from Ric mKO mice. This was associated with increased AMPK activity in Ric mKO muscle. Reducing AMPK kinase activity decreased muscle PLIN3 expression and IMTG content. AMPK agonism, in turn, increased PLIN3 expression in a FoxO1...

Remote Ischemic Conditioning

Science.gov (United States)

Heusch, Gerd; Bøtker, Hans Erik; Przyklenk, Karin; Redington, Andrew; Yellon, Derek

2014-01-01

In remote ischemic conditioning (RIC) brief, reversible episodes of ischemia with reperfusion in one vascular bed, tissue or organ confer a global protective phenotype and render remote tissues and organs resistant to ischemia/reperfusion injury. The peripheral stimulus can be chemical, mechanical or electrical and involves activation of peripheral sensory nerves. The signal transfer to the heart or other organs is through neuronal and humoral communications. Protection can be transferred, even across species, with plasma-derived dialysate and involves nitric oxide, stromal derived factor-1α, microRNA-144, but also other, not yet identified factors. Intracardiac signal transduction involves: adenosine, bradykinin, cytokines, and chemokines, which activate specific receptors; intracellular kinases; and mitochondrial function. RIC by repeated brief inflation/deflation of a blood pressure cuff protects against endothelial dysfunction and myocardial injury in percutaneous coronary interventions, coronary artery bypass grafting and reperfused acute myocardial infarction. RIC is safe and effective, noninvasive, easily feasible and inexpensive. PMID:25593060

The Later Wittgenstein and the Later Husserl on Language

Directory of Open Access Journals (Sweden)

Paul Ricoeur

2014-07-01

Full Text Available This article presents an edited version of lectures given by Paul Ricœur at Johns Hopkins University in April 1966. Ricœur offers a comparative analysis of Wittgenstein’s and Husserl’s late works, taking the problem of language as the common ground of investigation for these two central figures of phenomenology and analytic philosophy. Ricœur develops his study in two parts. The first part considers Husserl’s approach to language after the Logical Investigations and concentrates on Formal and Transcendental Logic; leaving a transcendental reflection on language behind it re-examines a phenomenological conception, according to which the sphere of logic is not separable from that of experience. The main focus of the second part is Wittgenstein’s later philosophy as it moved on from the conception of an isomorphic relation between language and the world, as set out in the picture theory in the Tractatus Logico-Philosophicus, to the more pragmatic notion of a language-game in the Philosophical Investigations. In order to get beyond the irrevocable differences between the two philosophies and the unresolved theoretical issues on both sides, Ricœur suggests turning to a semiological paradigm based on the Saussurean distinction between “language” and “speaking.” Keywords: Analytic Philosophy, Husserl, Phenomenology, Semiology, Wittgenstein.Résumé Cet article est une version éditée de conférences données par Paul Ricœur à la Johns Hopkins University en avril 1966. Ricœur propose une analyse comparée des dernières œuvres de Wittgenstein et Husserl, avec le problème du langage comme sol commun d’investigations pour ces deux figures centrales de la phénoménologie et la philosophie analytique. Cette analyse de Ricœur se joue à travers deux parties. La première partie revient sur l'approche du langage chez Husserl depuis Recherches logiques avec une attention particulière aux développements de Logique formelle et

Development of a surgical site infection (SSI) surveillance system, calculation of SSI rates and specification of important factors affecting SSI in a digestive organ surgical department.

Science.gov (United States)

Kimura, Koji; Sawa, Akihiro; Akagi, Shinji; Kihira, Kenji

2007-06-01

We have developed an original system to conduct surgical site infection (SSI) surveillance. This system accumulates SSI surveillance information based on the National Nosocomial Infections Surveillance (NNIS) System and the Japanese Nosocomial Infections Surveillance (JNIS) System. The features of this system are as follows: easy input of data, high generality, data accuracy, SSI rate by operative procedure and risk index category (RIC) can be promptly calculated and compared with the current NNIS SSI rate, and the SSI rates and accumulated data can be exported electronically. Using this system, we monitored 798 patients in 24 operative procedure categories in the Digestive Organs Surgery Department of Mazda Hospital, Mazda Motor Corporation, from January 2004 through December 2005. The total number and rate of SSI were 47 and 5.89%, respectively. The SSI rates of 777 patients were calculated based on 15 operative procedure categories and Risk Index Categories (RIC). The highest SSI rate was observed in the rectum surgery of RIC 1 (30%), followed by the colon surgery of RIC3 (28.57%). About 30% of the isolated infecting bacteria were Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. Using quantification theory type 2, the American Society of Anesthesiology score (4.531), volume of hemorrhage under operation (3.075), wound classification (1.76), operation time (1.352), and history of diabetes (0.989) increased to higher ranks as factors for SSI. Therefore, we evaluated this system as a useful tool in safety control for operative procedures.

Tidal and residual currents across the northern Ryukyu Island chain observed by ferryboat ADCP

Science.gov (United States)

Liu, Zhao-Jun; Nakamura, Hirohiko; Zhu, Xiao-Hua; Nishina, Ayako; Dong, Menghong

2017-09-01

Ferryboat Acoustic Doppler Current Profiler (ADCP) data from 2003 to 2012 are used to estimate the tidal and residual currents across the northern Ryukyu Island chain (RIC) between the islands of Okinawa and Amamioshima. In this region, the M2 tide current is the strongest tidal component, and the K1 tide current is the strongest diurnal tidal component. The corresponding maximum amplitudes are 40 and 34 cm s-1, respectively. After removal of the tidal currents, the mean volume transport, 1.5 ± 2.7 Sv, flows into the East China Sea (ECS) from the western North Pacific through four channels in this area. In an empirical orthogonal function (EOF) analysis performed to clarify the temporal and spatial variability of currents through the four channels, the first two EOF modes account for 71% and 18% of the total variance, respectively. The EOF1 mode shows a clear bottom-intensified mode through the deep channel, which is likely to be formed by the propagation of bottom-trapped long topographic Rossby wave caused by the impingement of westward-propagating mesoscale eddies upon the eastern slope of the northern RIC. The EOF2 mode has significant seasonal variability and may be driven by the wind stress prevailing over the Kuroshio flow region around the northern RIC in October-November. This study provides observational evidence of the water exchanges across the northern RIC, which is essential for constructing a circulation scheme in the North Pacific subtropical western boundary region.

A vision of transdisciplinarity laying foundations for a world knowledge dialogue

CERN Document Server

Darbellay, Frederic; Billotte, Jerome; Waldvogel, Francis

2008-01-01

AcknowledgementsWhere, and Whence ?by André HurstThe Rules of the Game for a Knowledge Dialoguexby Dame Julia HigginsIntroductionFor a World Knowledge Dialogueby Frédéric Darbellay, Moira Cockell, Jérôme Billotte andFrancis WaldvogelChapter 1 Complexity and Neurosciences in Dialogue :Towards a New Theory of the Brain ?1.1 From Brain Dynamics to Consciousness :How Matter Becomes ImaginationAnalysis by Frédéric Darbellay of the presentationby Gerald M. Edelman1.2 Towards a Neuroscience of the Capable Perso

Radiation-induced electrical conductivity in MgAl2O4 spinel

International Nuclear Information System (INIS)

Pells, G.P.

1990-12-01

The d.c. electrical conductivity of high purity, polycrystalline MgAl 2 O 4 spinel of 99.5% theoretical density has been measured during irradiation by 18 MeV protons at reactor relevant ionization dose rates. The radiation-induced conductivity (RIC) at 200 C varied in a slightly sub-linear manner with dose rate. At temperatures between 250-350 C the RIC varied in a complex manner with the dose rate dependence being itself dose rate dependent. At higher temperatures the RIC reverted to an essentially linear variation with dose rate. The complex dose rate dependence is ascribed to the magnesium vacancy concentration introduced by the small Al 2 O 3 excess (MgO:Al 2 O = 1:1.05) and the presence of anti-structure defects producing large concentrations of intrinsic electron and hole traps. There was no evidence that the accumulation of radiation damage influenced the details of radiation-induced conductivity and MgAl 2 O 4 retained reasonable insulating properties at the highest dose rate and temperature. (author)

Micro Insert Moulding for the Production of 8 Pin RIC Socket for Hearing Aid Applications

DEFF Research Database (Denmark)

Islam, Aminul; Hansen, Hans Nørgaard; Larsen, Jacob W.

- one based on semi-automated process and the other one is fully automated process. Current report presents the entire process chain for both the concepts and makes a comparative analysis based on the experimental investigation and validation. The work presented here can be a source of valuable...

Tumor sterilization dose and radiation induced change of the brain tissue in radiotherapy of brain tumors

International Nuclear Information System (INIS)

Yoshii, Yoshihiko; Maki, Yutaka; Takano, Shingo

1987-01-01

Ninety-seven patients with brain tumors (38 gliomas, 26 brain metastases, 18 sellar tumors, 15 others) were treated by cobalt gamma ray or proton radiotherapy. In this study, normal brain injury due to radiation was analysed in terms of time-dose-fractionation (TDF), nominal standard dose (NSD) by the Ellis formula and NeuNSD by a modification in which the N exponent was -0.44 and the T exponent was -0.06. Their calculated doses were analysed in relationship to the normal brain radiation induced change (RIC) and the tumor sterilization dose. All brain tumors with an exception of many patients with brain metastases were received a surgical extirpation subtotally or partially prior to radiotherapy. And all patients with glioma and brain metastasis received also immuno-chemotherapy in the usual manner during radiotherapy. The calculated dose expressed by NeuNSD and TDF showed a significant relationship between a therapeutic dose and a postradiation time in terms of the appearance of RIC. It was suggested that RIC was caused by a dose over 800 in NeuNSD and a dose over 70 in TDF. Furthermore, it was suggested that an aged patient and a patient who had the vulnerable brain tissue to radiation exposure in the irradiated field had the high risk of RIC. On the other hand, our results suggested that the tumor sterilization dose should be over 1,536 NeuNSD and the irradiated method should be further considered in addition to the radiobiological concepts for various brain tumors. (author)

OntoWEDSS - An Ontology-based Environmental Decision-Support System for the management of Wastewater treatment plants

OpenAIRE

Ceccaroni, Luigi

2001-01-01

Les contribucions d'aquesta tesi uneixen dues disciplines: ciències ambientals (específicament, gestió d'aigües residuals) i informàtica (específicament, intel·ligència artificial). El tractament d'aigües residuals com a disciplina opera fent servir un rang de diferents enfocaments i mètodes que inclouen: control manual, control automàtic on-line, modelat numèric o no-numèric, models estadístics i simulacions. La tesi caracteritza la recerca interdisciplinària de tècniques d'intel·ligència ar...

Surface shear stress dependence of gas transfer velocity parameterizations using DNS

Science.gov (United States)

Fredriksson, S. T.; Arneborg, L.; Nilsson, H.; Handler, R. A.

2016-10-01

Air-water gas-exchange is studied in direct numerical simulations (DNS) of free-surface flows driven by natural convection and weak winds. The wind is modeled as a constant surface-shear-stress and the gas-transfer is modeled via a passive scalar. The simulations are characterized via a Richardson number Ri=Bν/u*4 where B, ν, and u* are the buoyancy flux, kinematic viscosity, and friction velocity respectively. The simulations comprise 0Ric or kg=AShearu*Sc-n, Ri<Ric. Here ABuoy=0.4 and AShear=0.1 are constants, and n is an exponent that depends on the water surface-characteristics.

Evidence for a GVL effect following reduced-intensity allo-SCT in ALL: a British Society of Blood and Marrow Transplantation study.

Science.gov (United States)

Medd, P G; Peniket, A J; Littlewood, T J; Pearce, R; Perry, J; Kirkland, K E; Shaw, B E; Potter, M N; Craddock, C F; Milligan, D W; Fielding, A K; Marks, D I; Cook, G

2013-07-01

Myeloablative allo-SCT decreases relapse incidence (RI) in ALL. Reduced intensity conditioning (RIC) may extend allo-SCT to older and less fit patients. Sixty-nine ALL patients reported to the BSBMT underwent fludarabine-based RIC allo-SCT, 38 from unrelated donors (UD). Forty-four patients received alemtuzumab. ALL was in CR in 64 patients (93%). This was a second or third SCT in 23 patients. Two-year OS and PFS were 36% and 32%, respectively. In multivariate analysis male recipients demonstrated better OS and PFS (hazard ratio (HR) = 0.42, P = 0.008 and HR = 0.45, P = 0.012, respectively). Two-year TRM was 29%: higher with younger age (HR = 0.97/year, P = 0.041), female recipient (HR = 2.55, P = 0.049) and increasing grade of acute GVHD (HR = 1.87, P = 0.001). Two-year RI was 38% and was lower in patients with acute and chronic GVHD (HR = 0.62 per increasing grade, P = 0.035 and HR = 0.52, P = 0.025, respectively). Long-term ALL-free survival is achievable following fludarabine-based RIC allo-SCT. The association between GVHD and decreased RI suggests the presence of a GVL effect.

Lightning Physics: A Three Year Program

Science.gov (United States)

1983-01-01

because these aircraft are controlled poeal’ r r o(z’, I- RIC) with low-voltage digital electronics and are in part construct- 4w J(,3 cR "*t • at ed of... millise - limits pretrigger and delayed-trigger mode,. and a variety of sample conds, and hundreds of microseconds, respectively, the time of simple...processes, but we feel it prudent to discontinue use of the Proctor, D. E., A radio study of lightning, Ph.D. thesis , Univ. of designations in order

Reinventing Organisations and the Future of Work

CERN Multimedia

CERN. Geneva

2016-01-01

Frédéric Laloux works as an adviser, coach, and facilitator for corporate leaders who feel called to explore fundamentally new ways of organizing. A former associate partner with McKinsey & Co., he holds an MBA from INSEAD. Frédéric Laloux is the author of the much talked about book "Reinventing Organizations". His fundamental research in the field of emerging organizational models has been described as ground-breaking, brilliant, spectacular, impressive, and world changing by some of the most respected scholars in the field of human development. youtu.be/gcS04BI2sbk

Inmigrantes en formación : estado de bienestar y promoción de lazos sociales en el caso de la formación para la inserción laboral de las personas inmigrantes en Barcelona

OpenAIRE

Yufra, Laura Cristina

2013-01-01

La tesi constitueix un recorregut teòric-empíric al voltant de la configuració sociopolítica del fenomen de la immigració com "problema d'Estat" a partir de l'estudi del cas de la formació per a la inserció laboral. S'assenyala la intrínseca relació entre immigració i Estat i s'identifiquen els processos de transformació en la promoció dels llaços socials per part de l'anomenat Estat "de benestar". En el desenvolupament del treball s'analitza l'accés als recursos de formació de les persones i...

[Methodologies of publications in the Revista de Investigación Clínica during the last 20 years].

Science.gov (United States)

López-Jiménez, F; Borovoy, J

1997-01-01

To characterize the clinical research methods published in the Revista de Investigación Clínica for the past 20 years. Comparative study of methods used in the RIC articles published in 3-years periods representing three decades (1972-74, 1982-84, 1992-94). Out of 273 original papers, 218 (80%) were of clinical research. There was an increased percentage of longitudinal vs cross-sectional studies, with cohort and randomized clinical trials showing the largest increase. The total number of research manuscripts also increased. The clinical research methods of the papers in the RIC have shown an increased rate of designs with a higher scientific value.

Effect of electrodes in the radiation induced conductivity for polymers

International Nuclear Information System (INIS)

Gregorio Filho, R.; Gross, B.

1988-01-01

Samples of PET with 23 μm thickness were exposed to continuous X-rays and the radiation-induced conductivity (RIC) as a function of time were measured, using electrodes of evaporated aluminum and gold. The results showed that the use of higher atomic number metal electrodes increase the received dose rate by sample, without almost modifying the time evolution of the RIC or its dependence with the applied electric field intensity. It is also showed that this increase is caused by the electrode placed in the face of the sample where the radiation strikes, as well as by the one placed in the oposite face. (author) [pt

Modernization project of the rod control system and in-core instrumentation system for 34 units of the 900 MW French EDF fleet

International Nuclear Information System (INIS)

Tavolara, Ivan; Verburgh, Pierre; Menager, Antoine

2010-01-01

Rolls-Royce and Cegelec, in partnership, carry out a unique and considerable modernisation project of two Instrumentation and Control (I and C) systems for the entire 900 MWe fleet of Electricite De France (EDF). Both rod control (RCS) and reactor in-core measurement (RIC) systems are to be modernised in the frame of the third ten-year renovation of all 34 reactor units over 9 power plants. The RCS contributes to the control of nuclear power by actuating control rod drive mechanisms that allow insertion or withdrawal of control rods. The RCS has also monitoring functions such as controlling the actual rods' position as well as the functional consistency between commands and actual positions. The RIC system measures in-core neutron flux, providing useful information to the control room as well as to the reactor unit computer for further processing. The renovated systems shall replace the existing ageing analog technology by modern digital technology based on PLC (Programmable Logic Controllers) and FPGA (Field-Programmable Gate Array) in the case of power subassemblies of RCS. Both systems rely for certain functions on a common network linking the RCS and RIC networks, improving operations and maintenance thanks to a powerful Man Machine Interface at the different locations of the systems with an extensive suite of tools and diagnostic menus. The project whose design phase started in July 2006 is now in its deployment phase after the successful site implementation of both systems at the first units of Tricastin and Fessenheim power plants, respectively in August 2009 and February 2010. The deployment shall continue with the other 32 units until 2020. Rolls-Royce has a broad range of civil nuclear expertise, including work related to licensing and safety reviews, engineering design, supply chain management, manufacturing, installation and commissioning of the nuclear island systems and equipment, as well as operational management through life support. Cegelec, with

Toward the Validation of Depth-Averaged Three Dimensional, Rans Steady-State Simulations of Fluvial Flows at Natural Scale

Science.gov (United States)

Mateo Villanueva, P. A.; Hradisky, M.

2010-12-01

Simulations of fluvial flows are strongly influenced by geometric complexity and overall uncertainty on measured flow variables, including those assumed to be well known boundary conditions. Often, 2D steady-state models are used for computational simulations of flows at the scale of natural rivers. Such models have been successfully incorporated in iRIC (formerly MD_SWMS), one of the widely used quasi-3D CFD solvers to perform studies of environmental flows. iRIC aids in estimating such quantities as surface roughness and shear stress, which, in turn, can be used to estimate sediment transport. However, the computational results are inherently limited in accuracy because of restricting the computations to 2D, or quasi-3D, space, which can affect the values of these predictions. In the present work we perform computer-based simulations of fluvial flows using OpenFOAM, a free, open source fully 3D CFD software package, and compare our results to predictions obtained from iRIC. First, we study the suitability of OpenFOAM as the main CFD solver to analyze fluvial flows and validate our results for two well documented rectangular channel configurations: the first case consists of a large aspect-ratio channel (ratio of depth over width 0.017, ratio of depth over length 0.0019) with a rectangular obstacle mounted at the bottom wall; the second case involves a large aspect-ratio channel (ratio of depth over width 0.1, ratio of depth over length 0.0025) with cubic obstacles mounted at the lower wall (one obstacle) and upper wall (two obstacles). Secondly, we apply our model to simulation or river at natural scale and compare our results to the output obtained from iRIC to quantify the differences in velocity profiles and other flow parameters when comparable solution techniques are used. Steady-state, RANS k-epsilon models are employed for all simulations.

Sugarcane root length density and distribution from root intersection counting on a trench-profile Densidade de comprimento e distribuição de raízes de cana-de-açúcar a partir da contagem de intersecção de raízes na parede do perfil

Directory of Open Access Journals (Sweden)

Mateus Carvalho Basilio de Azevedo

2011-02-01

Full Text Available Root length density (RLD is a critical feature in determining crops potential to uptake water and nutrients, but it is difficult to be measured. No standard method is currently available for assessing RLD in the soil. In this study, an in situ method used for other crops for studying root length density and distribution was tested for sugarcane (Saccharum spp.. This method involved root intersection counting (RIC on a Rhodic Eutrudox profile using grids with 0.05 x 0.05 m and modeling RLD from RIC. The results were compared to a conventional soil core-sampled method (COR (volume 0.00043 m³. At four dates of the cropping season in three tillage treatments (plowing soil, minimum tillage and direct planting, with eight soil depths divided in 0.1 m soil layer (between 0-0.6 and 1.6-1.8 m and three horizontal distances from the row (0-0.23, 0.23-0.46 and 0.46-0.69 m, COR and RIC methods presented similar RLD results. A positive relationship between COR and RIC was found (R² = 0.76. The RLD profiles considering the average of the three row distances per depth obtained using COR and RIC (mean of four dates and 12 replications were close and did not differ at each depth of 0.1 m within a total depth of 0.6 m. Total RLD between 0 and 0.6 m was 7.300 and 7.100 m m-2 for COR and RIC respectively. For time consumption, the RIC method was tenfold less time-consuming than COR and RIC can be carried out in the field with no need to remove soil samples. The RLD distribution in depth and row distance (2-D variability by RIC can be assessed in relation to the soil properties in the same soil profiles. The RIC method was suitable for studying these 2-D (depth and row distance in the soil profile relationships between soil, tillage and root distribution in the field.A densidade de comprimento de raízes (DCR é uma característica importante para determinar o potencial de absorção de água e nutrientes das plantas, mas é difícil de ser medida. Nenhum m

Mémoires et conflits: Conflits des mémoires, collision des durées

Directory of Open Access Journals (Sweden)

Jean-Louis Vieillard-Baron

2014-01-01

Full Text Available There is a collision between the durations and between the memories, every time that duration rythms are different. For Bergson there is a difference of degrees of tension between durations but the flow is unique. Ricœur distinguishes many degrees of passeity according to the proximity or the distance. As example he sets the Zauberberg of Thomas Mann. Forgetting and Forgiveness are forms of durations collision. The distensio animi of Saint Augustine means dissipation  Ricœur misunderstands this expression what means for him phenomenological intratemporality, and he goes no further than tearing of soul distant from eternity. Normal 0 false false false EN-US JA X-NONE

Preparation and preclinical evaluation of 211At-labelled compounds for α-particle radiotherapy

International Nuclear Information System (INIS)

Larsen, R.H.

1994-01-01

The present work demonstrate that significant therapeutic gain can be achieved with 211 At-labelled MoAbs on single tumour cells and microscopic disease. Β-emitters are less effective on microscopic disease because of radiation dispersion, while longer halflives (e.g., 90 Y and 131 I) allow favourable therapeutic ratios to be reached in larger tumors. 211 At-labelled MoAbs may therefore possibly be used in combination with β-emitting RIC in systemically delivered radioimunnotherapy. Larger tumor nodules are then irradiated effectively due to cross-fire of the longer ranged β-particles while the fraction of tumour cells distributed as single cells and micrometastases may be more effectively radiated with 211 At-RIC. 76 refs

Allogeneic Hematopoietic Cell Transplantation for Older Patients: Prognosis Determined by Disease Risk Index.

Science.gov (United States)

He, Fiona; Cao, Qing; Lazaryan, Aleksandr; Brunstein, Claudio; Holtan, Shernan; Warlick, Erica; Ustun, Celalettin; McClune, Brian; Arora, Mukta; Rashidi, Armin; Eckfeldt, Craig; Weisdorf, Daniel J; Bejanyan, Nelli

2017-09-01

The treatment of elderly patients with advanced hematological malignancies has expanded to include reduced-intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (alloHCT) as a potentially curative option. We studied the association between Disease Risk Index (DRI) and clinical outcomes of 196 elderly patients (median age, 64.8; range, 60 to 75 years) with hematological malignancies receiving RIC alloHCT (2000 to 2014). Donors were related and unrelated adults (n = 100, 51.1%) or umbilical cord blood (n = 96, 48.9%). DRI classified 12 patients (6.1%) as low risk (LR), 146 patients (74.5%) as intermediate risk (IR), and 38 patients (19.4%) as high risk (HR). Two-year overall survival (OS) was 47% (52% for LR/IR versus 29% for HR, P risk of relapse (hazard ratio, 2.07; 95% confidence interval [CI], 1.34 to 3.33; P = .02) and treatment failure (hazard ratio, 2.07; 95% CI, 1.35 to 3.18; P risk of relapse leading to poor survival in HR DRI, participation in clinical trials offering relapse prevention strategies after RIC alloHCT should be encouraged when available. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Measurements of Prompt Radiation-Induced Conductivity of Pyralux®

Energy Technology Data Exchange (ETDEWEB)

Hartman, E. Frederick [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Radiation Effects Experimentation Dept.; Zarick, Thomas Andrew [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Radiation Effects Experimentation Dept.; McLain, Michael Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Radiation Effects Experimentation Dept.; Sheridan, Timothy J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Radiation Effects Experimentation Dept.; Preston, Eric F. [ITT Exelis, Colorado Springs, CO (United States); Stringer, Thomas Arthur [ITT Exelis, Colorado Springs, CO (United States)

2014-01-01

In this report, measurements of the prompt radiation-induced conductivity (RIC) in 3 mil samples of Pyralux® are presented as a function of dose rate, pulse width, and applied bias. The experiments were conducted with the Medusa linear accelerator (LINAC) located at the Little Mountain Test Facility (LMTF) near Ogden, UT. The nominal electron energy for the LINAC is 20 MeV. Prompt conduction current data were obtained for dose rates ranging from ~2 x 10⁹ rad(Si)/s to ~1.1 x 10¹¹ rad(Si)/s and for nominal pulse widths of 50 ns and 500 ns. At a given dose rate, the applied bias across the samples was stepped between -1500 V and 1500 V. Calculated values of the prompt RIC varied between 1.39x10^-8 Ω^-1 · m^-1 and 2.67x10^-7 Ω^-1 · m^-1 and the prompt RIC coefficient varied between 1.25x10^-18 Ω^-1 · m^-1/(rad/s) and 1.93x10^-17 Ω^-1 · m^-1/(rad/s).

Modernization project of the rod control system and in-core instrumentation system for 34 units of the 900 MW French EDF fleet

International Nuclear Information System (INIS)

Tavolara, Ivan; Desgeorge, Romain; Verburgh, Pierre

2014-01-01

Rolls-Royce and Cegelec, in partnership, carry out a unique and considerable modernisation project of two Instrumentation and Control (I and C) systems for the entire 900 MWe fleet of Electricite De France (EDF). Both rod control (RCS) and reactor in-core measurement (RIC) systems are to be modernised in the frame of the third ten-year renovation of all 34 reactor units over 9 power plants. The RCS contributes to the control of nuclear power by actuating control rod drive mechanisms that allow insertion or withdrawal of control rods. The RCS has also monitoring functions such as controlling the actual rods' position as well as the functional consistency between commands and actual positions. The RIC system measures in-core neutron flux, providing useful information to the control room as well as to the reactor unit computer for further processing. The renovated systems shall replace the existing ageing analog technology by modern digital technology based on PLC (Programmable Logic Controllers) and FPGA (Field-Programmable Gate Array) in the case of power subassemblies of RCS. Both systems rely for certain functions on a common network linking the RCS and RIC networks, improving operations and maintenance thanks to a powerful Man Machine Interface at the different locations of the systems with an extensive suite of tools and diagnostic menus. The project whose design phase started in July 2006 is now in its deployment phase after the successful site implementation of both systems at the first of kind units of Tricastin and Fessenheim power plants, respectively in August 2009 and February 2010. With 20 units in operation in 2014, the deployment shall continue with the other 14 until 2020. Rolls-Royce has a broad range of civil nuclear expertise, including work related to licensing and safety reviews, engineering design, supply chain management, manufacturing, installation and commissioning of the nuclear island systems and equipment, as well as operational

QUEL CHE RESTA DELLA PSICANALISI. UNA LETTURA MERLEAU‐PONTIANA DI FREUD

Directory of Open Access Journals (Sweden)

Scotti, Alessandra

2015-12-01

Full Text Available This paper investigates Maurice Merleau‐Ponty’s interest about Freud’s philosophical works. It invokes the Freud’s recognition as “Master of the School of suspicion”, a famous definition made by Paul Ricœur. According to Ricœur, Freud’s theories take place within the philosophical stream that looks at “constituted cogito” with deep mistrust. Through the analysis of “Phenomenology of Perception” we can observe the accusation of “pansexuality” moved by Merleau‐Ponty. However, as Merleau‐ Ponty’s philosophy develops and his view changes from “existential” to “ontological”, the relation between Freud and Merleau‐Ponty changes accordingly, until the acknowledgment of the unconscious as a prediction of the “chair”.

Magneto-optical properties in inhomogeneous quantum dot: The Aharonov-Bohm oscillations effect

Energy Technology Data Exchange (ETDEWEB)

Nasri, Djillali, E-mail: nasri_dj@yahoo.fr [Faculté des Sciences Appliquées, Département de Génie Electrique, Université Ibn-Khaldoun de Tiaret, Zaaroura BP No. 78, Tiaret 14000 (Algeria); Laboratoirede Microphysique et de Nanophysique (LaMiN), Ecole Nationale Polytechnique d' Oran, BP 1523EL M' Naouer, Oran 31000 (Algeria); Bettahar, N. [Faculté des Sciences de la matière, Département de Physique, Université Ibn-Khaldoun de Tiaret, Zaaroura BP No. 78, Tiaret 14000 (Algeria)

2016-11-15

In this study, we investigated theoretically the effect of a magnetic field B on the linear, nonlinear, and total absorption coefficients (ACs) and the refractive index changes (RICs) associated with intersubband transitions in the HgS quantum shell. In the calculations, a diagonalization method was employed within the effective-mass approximation. We find that a three kinds of optical transitions (S–P, P–D and D–F) between the ground state and the first excited state appear, resulting from the oscillation of the ground state with B (Aharonov-Bohm effect). In the other hand, the magnetic field enhances and diminishes their related RICs and ACs intensities respectively for the three kinds of optical transitions, and shifts their peaks towards low energy (blue shift).

Dgroup: DG00872 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available DG00872 Chemical ... DGroup Cyamemazine ... D07307 ... Cyamemazine (INN) D07756 ... Cyamemazine tartrate Neuropsychiat...ric agent ... DG01905 ... Phenothiazine antipsychotics ATC code: N05AA06 Phenothiazine antipsychotics ...

Research and practice of application software verification and validation for nuclear safety digital I and C system

International Nuclear Information System (INIS)

Dong Yaxin; Xu Xianzhu; Bai Xiangji

2014-01-01

Application software V and V activities determine whether the output results are consistent with the requirements of tasks throughout each stage of application software development process, and confirm whether the ultimately generated application software is conform to its intended use and other related requirements. A set of reasonable and feasible workflow for application software V and V activities was proposed based on the characteristics of the application software in this paper, and was demonstrated with the application software V and V activities in transformation project of in-core instrumentation system (RIC) in a nuclear power plant. (authors)

Moodne aeg käib alla / Valner Valme

Index Scriptorium Estoniae

Valme, Valner, 1970-

2008-01-01

Arvustus: Beigbeder, Frédéric. Armastus kestab kolm aastat : romaan / prantsuse keelest tõlkinud Anti Saar. Tallinn : Varrak, 2008 ; Cusk, Rachel. Arlington Park / tõlkinud Kersti Unt. Tallinn : Varrak, 2007

Store turnover as a predictor of food and beverage provider turnover and associated dietary intake estimates in very remote Indigenous communities.

Science.gov (United States)

Wycherley, Thomas; Ferguson, Megan; O'Dea, Kerin; McMahon, Emma; Liberato, Selma; Brimblecombe, Julie

2016-12-01

Determine how very-remote Indigenous community (RIC) food and beverage (F&B) turnover quantities and associated dietary intake estimates derived from only stores, compare with values derived from all community F&B providers. F&B turnover quantity and associated dietary intake estimates (energy, micro/macronutrients and major contributing food types) were derived from 12-months transaction data of all F&B providers in three RICs (NT, Australia). F&B turnover quantities and dietary intake estimates from only stores (plus only the primary store in multiple-store communities) were expressed as a proportion of complete F&B provider turnover values. Food types and macronutrient distribution (%E) estimates were quantitatively compared. Combined stores F&B turnover accounted for the majority of F&B quantity (98.1%) and absolute dietary intake estimates (energy [97.8%], macronutrients [≥96.7%] and micronutrients [≥83.8%]). Macronutrient distribution estimates from combined stores and only the primary store closely aligned complete provider estimates (≤0.9% absolute). Food types were similar using combined stores, primary store or complete provider turnover. Evaluating combined stores F&B turnover represents an efficient method to estimate total F&B turnover quantity and associated dietary intake in RICs. In multiple-store communities, evaluating only primary store F&B turnover provides an efficient estimate of macronutrient distribution and major food types. © 2016 Public Health Association of Australia.

Stable long-term pulmonary function after fludarabine, antithymocyte globulin and i.v. BU for reduced-intensity conditioning allogeneic SCT.

Science.gov (United States)

Dirou, S; Malard, F; Chambellan, A; Chevallier, P; Germaud, P; Guillaume, T; Delaunay, J; Moreau, P; Delasalle, B; Lemarchand, P; Mohty, M

2014-05-01

Lung function decline is a well-recognized complication following allogeneic SCT (allo-SCT). Reduced-intensity conditioning (RIC) and in vivo T-cell depletion by administration of antithymocyte globulin (ATG) may have a protective role in the occurrence of late pulmonary complications. This retrospective study reported the evolution of lung function parameters within the first 2 years after allo-SCT in a population receiving the same RIC regimen that included fludarabine and i.v. BU in combination with low-dose ATG. The median follow-up was 35.2 months. With a median age of 59 years at the time of transplant, at 2 years, the cumulative incidences of non-relapse mortality was as low as 9.7%. The cumulative incidence of relapse was 33%. At 2 years, the cumulative incidences of extensive chronic GVHD (cGVHD) and of pulmonary cGVHD were 23.1% and 1.9%, respectively. The cumulative incidences of airflow obstruction and restrictive pattern were 3.8% and 9.6%, respectively. Moreover, forced expiratory volume (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio remained stable from baseline up to 2 years post transplantation (P=0.26, P=0.27 and P=0.07, respectively). These results correspond favorably with the results obtained with other RIC regimens not incorporating ATG, and suggest that ATG may have a protective pulmonary role after allo-SCT.

A new approach for simple radioisotope cisternography examination in cerebrospinal fluid leakage detection.

Science.gov (United States)

Hoshino, Hiromitsu; Higuchi, Tetsuya; Achmad, Arifudin; Taketomi-Takahashi, Ayako; Fujimaki, Hiroya; Tsushima, Yoshito

2016-01-01

We developed a new quantitative interpretation technique of radioisotope cisternography (RIC) for the diagnosis of spontaneous cerebrospinal fluid hypovolemia (SCH). RIC studies performed for suspected SCH were evaluated. (111)In-DTPA RIC images were taken at 0, 1, 3, 6, and 24-h after radioisotope injection following the current protocol. Regions of interest (ROI) were selected on 3-h images to include brain, spine, bladder or the whole body. The accumulative radioactivity counts were calculated for quantitative analysis. Final diagnoses of SCH were established based on the diagnostic criteria recently proposed by Schievink and colleagues. Thirty-five patients were focused on. Twenty-one (60.0%) patients were diagnosed as having SCH according to the Schievink criteria. On the 3-h images, direct cerebrospinal fluid leakage sign was detected in nine of 21 SCH patients (42.9%), as well as three patients with suspected iatrogenic leakage. Compared to non-SCH patients, SCH patients showed higher bladder accumulation at 3-h images (P = 0.0002), and higher brain clearance between the 6- and 24-h images (P leakage was not observed. 1- and 6-h images did not provide any additional information in any patients. A new simple ROI setting method, in which only the 3-h whole body and 24-h brain images were necessary, was sufficient to diagnose SCH.

Chronic whiplash-associated disorder and traumatic cerebrospinal fluid leak. Analysis of cases with radioisotope cisternography, epidural blood patch, and cervical facet joint blocks

International Nuclear Information System (INIS)

Ishikawa, Shinichi; Kobayashi, Hiroyuki; Takahara, Hiroshi; Kojo, Shigeru; Hashimoto, Hidenori; Moriyama, Eiji; Nishida, Ayumi

2008-01-01

This paper describes RI cisternographic (RIC) examinations of whiplash-associated disorder (WAD) and results of their treatment with nerve block and epidural blood patch (EBP) conducted in authors' facilities. Subjects were 40 chronic (av. symptomatic period of 3.1 y) WAD patients (av. age 34 y) with traffic (28 cases), sports (7) and falling (5) causes with complication of suspicious cerebrospinal fluid (CSF) leak. RIC was done 2.5-24 hr after injection of 37 MBq of 111 In-diethylenetriamine pentaacetic acid (DTPA) in the medullary space through epidural puncturing needle. Positive finding of clear leak or early accumulation of RI in the bladder was seen in 21 cases and negative, in 19. Positive patients had significantly higher rates of headache, abnormal vision and fatigue than negative ones. EBP was conducted through X-ray to all positive patients and to negative ones with strongly suspicious leak complication (7 cases), which resulted in improvement of symptoms like headache and vision in the former, but no improvement in the latter cases. Repeated RIC of the patients with poor improvement in the former was suggested effective for judgment of repetition of EBP treatment. Cervical facet joint blocks were found effective in cases with posterior cervical pain. Symptoms in WAD accompanying headache should be differentially diagnosed whether it is derived from posttraumatic CSF leak or from pain due to cervical facet arthritis. (R.T.)

Influence of entrainment and countergradient on the ABL diurnal development

Science.gov (United States)

Hernández-Ceballos, M. A.

2009-09-01

The representation of the diurnal evolution of the boundary layer (ABL) by NCAR-Penn State Mesoscale Model (MM5) and by the mesoscale model Weather Research Forecast (WRF) is compared. Special attention is paid to determine the role of processes that occur near and below the inversion zone: the positive correlation between the heat flux and the gradient (countergradient) and the role of entrainment of heat originating from the free troposphere. Both processes play a key role in the modelling of the diurnal variability of temperature, moisture and atmospheric compounds. A number of 13 simulations are carried out to determine the sensitivity of the model results to the formulation of the ABL height and countergradient heat flux in the Medium Range Forecast (MRF) ABL scheme. Model results are compared with experimental data obtained from the DOMINO (Diel Oxidant Mechanisms in relation to Nitrogen oxides) campaign. It was organized by Max Planck Institute for Atmospheric Chemistry (Germany) in collaboration with the National Institute for Aerospace Technology (Spain). The DOMINO campaign took place at the "Atmospheric Sounding Station - El Arenosillo", a platform dedicated to atmospheric measurements in the Southwest of Spain. All numerical experiments are grouped in four clusters, each focussing on the sensitivity of different relevant aspects. The following aspects of the formulation are analyzed: surface moisture availability (M), the countergradient term (γc) and the ABL height (h). This is done by modifying both the bulk critical Richardson number (Ric) at the inversion zone, and a coefficient of proportionality (b) that determines the excess temperature and countergradient. The importance of b is due to its direct relation in the definition of both, γc and h. The results got with MM5 model show that temperature and specific moisture temporal evolution is not very sensitive to changes in the soil moisture availability (M value from 0.6 to 0.1). Using the MRF

Anàlisi teòrica dels antecedents i conseqüències de la identificació de l'alumnat amb la universitat i de la seva percepció de qualitat universitària

Directory of Open Access Journals (Sweden)

Irene Trullas

2011-04-01

Full Text Available Objecte: L'objectiu d’aquest article és desenvolupar un model conceptual centrat en els antecedents de la identificació de l'alumnat amb la universitat i la seva percepció de la qualitat universitària, perquè investigacions futures puguin provar des d’un punt de vista empíric les proposicions assenyalades.Disseny/metodologia: La metodologia consisteix en una anàlisi de la literatura empírica existent i del models teòrics actuals enfocats en el màrqueting a nivell universitari. Resultats: La identificació de l’estudiant amb la universitat i la seva percepció de qualitat de la institució són dos variables claus per a la captació i la retenció de l’alumnat. Aquest article proposa que la identificació depèn del suport institucional percebut per l'estudiant, que al seu torn està positivament relacionat amb: la comunicació corporativa, la relació universitat-alumne i la relació alumne-alumne. D’altra banda, l’ocupabilitat d’una institució educativa és relaciona positivament amb la percepció de qualitat universitària per part de l’estudiant i aquesta percepció ve determinada per la bona reputació de la universitat i per la percepció de l’estudiant que la universitat fomenta l’ocupabilitat en la seva formació. Limitacions: El model presentat es fonamenta des d’un punt de vista teòric i per tant és un punt de partida de línies futures de caràcter empíric.Implicacions pràctiques: Aquest article teòric pretén donar un punt de sortida i nou enfocament al màrqueting universitari. Esperem que aquest article ajudi a accelerar el progrés en l’àmbit del màrqueting universitari, posant de relleu qüestions fonamentals que necessiten investigació futura.Implicacions socials: La confirmació del model conceptual donaria les eines necessàries perquè les universitats desenvolupin les seves estratègies de captació i retenció d'estudiants basant-se en el màrqueting i en la segmentació, fet que

Desafios na era pós genômica para o desenvolvimento de testes laboratoriais para o diagnóstico da hanseníase Challenges in the post genomic era for the development of tests for leprosy diagnosis

Directory of Open Access Journals (Sweden)

Mariane Martins de Araújo Stefani

2008-01-01

Full Text Available O diagnóstico da hanseníase se baseia em manifestações clínicas e não existe teste laboratorial para diagnosticar casos assintomáticos ou para prever progressão da doença entre indivíduos expostos. Novas análises genômicas comparativas in silico e ferramentas de biologia molecular têm sido empregadas para revelar proteínas exclusivas do Mycobacterium leprae que apresentem potencial aplicação diagnóstica. A hanseníase tuberculóide paucibacilar (PB apresenta baixo nível de anticorpos e forte resposta imune celular (RIC tipo Th1/interferon gamma (IFN-γ. A doença lepromatosa multibacilar (MB apresenta sorologia positiva e fraca RIC. Portanto, testes laboratoriais para diagnosticar hanseníase PB e MB devem contemplar testes de RIC e sorologia. Proteínas recombinantes do Mycobacterium leprae sorologicamente reativas podem ser incorporadas ao antígeno PGLI para melhorar o diagnóstico sorológico de pacientes MB. Proteínas recombinantes e peptídeos sintéticos do Mycobacterium leprae têm sido testados em ensaios de RIC/IFN-γ para diagnosticar casos PB. Sorologia anti-PGLI modificada incorporando novos antígenos do Mycobacterium leprae e ensaios baseados na RIC/produção de IFN-γ devem permitir a detecção precoce de casos MB e PB em países endêmicos.Leprosy diagnosis is based mainly on clinical manifestations and no laboratory test is available to diagnose asymptomatic disease or to predict disease progression among exposed individuals. Novel comparative genomic in silico analyses and molecular biology tools have discovered unique Mycobacterium leprae proteins with potential diagnostic application. Tuberculoid paucibacillary leprosy (PB shows low antibodies titers and strong Th1 type/ IFN-γ specific cell mediated immunity (CMI, while lepromatous multibacillary patients (MB show high antibody titers and low CMI. Therefore, laboratory tests for PB and MB leprosy diagnosis will require CMI and antibody based assays

L’imagination apprivoisée : représentation et factualité dans la connaissance historique

Directory of Open Access Journals (Sweden)

Pier Luigi Lecis

2017-12-01

Full Text Available This paper aims to show how Ricœur’s inquiry on memory, trace, and testimony contributes to rebalance a framework that, at the level of the dialectic between imagination and representation, would essentially present Historian’s work as a hermeneutical work. In Ricœur’s later writings, we find a differently balanced perspective by focusing the (neurobiological and psychological substrate of representation behind trace and memory. Representation precedes interpretation. And neither the fidelity of memory nor the epistemic truth of history belong to a game that would be solely played within the communicative space of a plurality of cognitive agents who are exchanging, controlling, and sharing their own experiences. Consequently, the reality of the past itself reemerges as the corollary of the practice of memory.

Communication, Translation and the Global Community of Persons

Directory of Open Access Journals (Sweden)

Dries Deweer

2015-07-01

Full Text Available Paul Ricœur shared Emmanuel Mounier’s personalist and communitarian ideal of a universal community, which ensures that every human being has access to the conditions for self-development as a person. Whereas Mounier talks about communication as the structure of personhood that summons us towards the gradual enlargement of the community, Ricœur’s reflections on translation provide a missing link by referring, not just to the human capacity to communicate, but more specifically, to our capacity to translate and the implied ethics of linguistic hospitality. This allowed him to show that what enables us to enlarge the circle of brotherhood is the capacity to gradually settle in the world of the other and to welcome the other into one’s own world.

Superresolution and Fluorescence Dynamics Evidence Reveal That Intact Liposomes Do Not Cross the Human Skin Barrier

DEFF Research Database (Denmark)

Dreier, Jes; Sørensen, Jens A; Brewer, Jonathan R

2016-01-01

In this study we use the combination of super resolution optical microscopy and raster image correlation spectroscopy (RICS) to study the mechanism of action of liposomes as transdermal drug delivery systems in human skin. Two different compositions of liposomes were applied to newly excised human...... skin, a POPC liposome and a more flexible liposome containing the surfactant sodium cholate. Stimulated emission depletion microscopy (STED) images of intact skin and cryo-sections of skin treated with labeled liposomes were recorded displaying an optical resolution low enough to resolve the 100 nm...... liposomes in the skin. The images revealed that virtually none of the liposomes remained intact beneath the skin surface. RICS two color cross correlation diffusion measurements of double labeled liposomes confirmed these observations. Our results suggest that the liposomes do not act as carriers...

Augustitantsud kanade ja põtradega / Kairi Prints

Index Scriptorium Estoniae

Prints, Kairi

2008-01-01

21.-23. aug. Tallinna Kanuti Gildi saalis toimunud Augusti tantsufestivali lavastustest - Sonia G̤mezi "Mi madre y yo', Frédéric Giesi "Dance (Practicable), Tatjana Gordejeva "Gallina Aquatica", Iguan Dance Theatre tantsulavastus "Radiodance"

Signature of a Collaboration agreement between Unitar & CERN.

CERN Multimedia

Pierre Gildemyn

2012-01-01

Signature of agreement with Mr Carlos Lopes (UNITAR) and Prof Rolf Heuer (CERN). From left to right : Einar Bjorgo, Francesco Pisano, Calors Lopes, Rolf Heuer, Maurizio Bona, Frédéric Hemmer, Olivier Van Damme

Prune Belly Syndrome

African Journals Online (AJOL)

User

dramnios are detected is increasingly becoming the norm. However, in resource ... ric ultrasound scan (USG) in the second trimester ... HBsAg, G6PD, retroviral screen and VDRL) was ... stalsis. The baby had normal external male genitalia.

75 FR 53667 - Space Coast Regional Innovation Cluster Competition

Science.gov (United States)

2010-09-01

... Coast Regional Innovation Cluster Competition AGENCY: Economic Development Administration (EDA... upcoming availability of funding for the Space Coast Regional Innovation Cluster (RIC) Competition under... economic development initiatives aligned with regional cluster and competitiveness analyses to sustain the...

Allogeneic cellular immunotherapy for chronic B-cell leukemia

NARCIS (Netherlands)

Hoogendoorn, Mels

2007-01-01

Allogeneic stem cell transplantation (SCT) following reduced-intensity conditioning (RIC) as treatment modality has curative potential in patients suffering from chronic lymphocytic leukemia (CLL) or mantle cell lymphoma (MCL), illustrating susceptibility of these leukemic cells for the

ORIGINAL ARTICLE

African Journals Online (AJOL)

User

naire was administered to optometrists attending the 37th annual general meeting of the Nigerian Optomet- ric Association. ..... new cases of blindness yearly in the United States. (CDC ... estimates and general information on dia- betes and ...

Outcomes of allogeneic stem cell transplantation in patients with paroxysmal nocturnal hemoglobinuria with or without aplastic anemia.

Science.gov (United States)

Lee, Sung-Eun; Park, Sung Soo; Jeon, Young-Woo; Yoon, Jae-Ho; Cho, Byung-Sik; Eom, Ki-Sung; Kim, Yoo-Jin; Lee, Seok; Min, Chang-Ki; Kim, Hee-Je; Cho, Seok-Goo; Kim, Dong-Wook; Min, Woo-Sung; Lee, Jong Wook

2017-10-01

The aim of this study was to evaluate the long-term outcomes of allogeneic stem cell transplantation (SCT) in patients with paroxysmal nocturnal hemoglobinuria (PNH) with or without aplastic anemia (AA). A total of 33 patients with PNH clones who underwent allogeneic SCT were analyzed. After a median follow-up of 57 months (range, 6.0-151.3), the 5-year estimated overall survival rate was 87.9±5.7%. Four patients died of transplant-related mortality (TRM). With the exception of one patient with early TRM, 32 patients were engrafted. Two patients who had developed delayed GF received a second transplant and recovered. The cumulative incidences of acute graft-vs-host disease (GVHD) (≥grade II) and chronic GVHD (≥moderate) were 27.3±7.9% and 18.7±7.0%, respectively. Twenty-one patients receiving SCT with reduced-intensity conditioning (RIC) had available follow-up data for PNH cell population for the first 6 months post-transplant. Analysis of these data revealed that the PNH clones disappeared within approximately 2 months. RIC regimen was sufficient to eradicate PNH clones with sustained donor-type engraftment after allogeneic SCT. Therefore, application of allogeneic SCT with RIC should be considered in patients with PNH, in accordance with the severity of the underlying bone marrow failure. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era

DEFF Research Database (Denmark)

Warlick, Erica; Ahn, Kwang Woo; Pedersen, Tanya L

2012-01-01

Tyrosine kinase inhibitors (TKIs) and reduced intensity conditioning (RIC)/nonmyeloablative (NMA) conditioning hematopoietic cell transplants (HCTs) have changed the therapeutic strategy for chronic myelogenous leukemia (CML) patients. We analyzed post-HCT outcomes of 306 CML patients reported to...

Weight and psychiatry

African Journals Online (AJOL)

Adele

Beyond the physical aspects of weight, the psychological mean- ing sees the virtues of ... sion in the development and persistence of adolescent obesity. Pediat- rics 2002 ... or secondary as in mood, anxiety or psychotic disorders. II. a related.

Untitled

African Journals Online (AJOL)

objective of this study was to determine the type and amount of solid wastes generated and to assess the ... ric pathogens by providing feeding stock and favorable environment. Ground and ..... WHO, News letter on Environmental. Health, No ...

The bioethics of cosmetic psychopharmacology

African Journals Online (AJOL)

Adele

ric disorders, but also for sub-clinical symptoms, and on the possible ... major advance in psychiatry, that they suffer from depression ... The language we use in discussing scientific and medical .... can Journal of Psychiatry 155, 373-379. 1998.

Spatiotemporal visualization of subcellular dynamics of carbon nanotubes

KAUST Repository

Serag, Maged F.; Braeckmans, Kevin; Habuchi, Satoshi; Kaji, Noritada; Bianco, Alberto; Baba, Yoshinobu

2012-01-01

throughout the plant cell. By using raster scan image correlation spectroscopy (RICS), we were able to generate highly quantitative spatial maps of CNTs diffusion in different cell compartments. The spatial map of diffusion values revealed that the uptake

Download this PDF file

African Journals Online (AJOL)

abel

imperial networks – multi-directional web-like systems that existed between the ... For example, the heads of the LMP and RIC both reported directly to Cabinet officials ... England, selection committees preferred to hire military officers as chief ...

Adhesion defective BHK cell mutant has cell surface heparan sulfate proteoglycan of altered properties

DEFF Research Database (Denmark)

Couchman, J R; Austria, R; Woods, A

1988-01-01

In the light of accumulating data that implicate cell surface heparan sulfate proteoglycans (HSPGs) with a role in cell interactions with extracellular matrix molecules such as fibronectin, we have compared the properties of these molecules in wild-type BHK cells and an adhesion-defective ricin......-resistant mutant (RicR14). Our results showed that the mutant, unlike BHK cells, cannot form focal adhesions when adherent to planar substrates in the presence of serum. Furthermore, while both cell lines possess similar amounts of cell surface HSPG with hydrophobic properties, that of RicR14 cells had decreased...... sulfation, reduced affinity for fibronectin and decreased half-life on the cell surface when compared to the normal counterpart. Our conclusions based on this data are that these altered properties may, in part, account for the adhesion defect in the ricin-resistant mutant. Whether this results from...

The 5T mouse multiple myeloma model: Absence of c-myc oncogene rearrangement in early transplant generations

NARCIS (Netherlands)

Radl, J.; Punt, Y.A.; Enden-Vieveen, M.H.M. van den; Bentvelzen, P.A.J.; Bakkus, M.H.C.; Akker T., W. van den; Benner, R.

1990-01-01

Consistent chromosomal translocations involving the c-myc cellular oncogene and one of the three immunoglobulin loci are typical for human Burkitt's lymphoma, induced mouse plasmacytoma (MPC) and spontaneously arising rat immunocytoma (RIC). Another plasma cell malignancy, multiple myeloma (MM),

75 FR 63147 - Solicitation of Applications for the Public Works, Economic Adjustment Assistance, and Global...

Science.gov (United States)

2010-10-14

... development of regional innovation clusters (RICs), which are broadly defined as geographic concentrations of... submit paper submissions to: Economic Development Administration, Atlanta Regional Office, 401 West... Development Administration, Austin Regional Office, 504 Lavaca, Suite 1100, Austin, Texas 78701- 2858...

Impact of postremission consolidation chemotherapy on outcome after reduced-intensity conditioning allogeneic stem cell transplantation for patients with acute myeloid leukemia in first complete remission

DEFF Research Database (Denmark)

Yeshurun, Moshe; Labopin, Myriam; Blaise, Didier

2014-01-01

The objective of the current study was to investigate the role of postremission consolidation chemotherapy before reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (alloSCT) for patients with acute myeloid leukemia (AML) in first complete remission (CR1)....

Influence of long-term treatment with glyceryl trinitrate on remote ischemic conditioning

DEFF Research Database (Denmark)

Hauerslev, Marie; Mørk, Sivagowry Rasalingam; Pryds, Kasper

2018-01-01

Remote ischemic conditioning (RIC) protects against sustained myocardial ischemia. Due to overlapping mechanisms this protection may be altered by glyceryl trinitrate (GTN), which is commonly used in the treatment of patients with chronic ischemic heart disease. We investigated whether long-term ...

A Large Solid Inner Core at Mercury

Science.gov (United States)

Genova, A.; Goossens, S.; Mazarico, E.; Lemoine, F. G.; Neumann, G. A.; Kuang, W.; Sabaka, T. J.; Smith, D. E.; Zuber, M. T.

2018-05-01

New measurements of the polar moments of inertia of the whole planet and of the outer layers (crust+mantle), and simulations of Mercury’s magnetic field dynamo suggest the presence of a solid inner core with a Ric 0.3-0.5 Roc.

Identification of novel open reading frames from metagenomic libraries generated from extremophilic organisms: application of metagenomics and high throughput screening for novel enzyme isolation

CSIR Research Space (South Africa)

Visser, Daniel F

2006-10-01

Full Text Available : Olive Oil / Rhodamine B Tributyrin Fluorescence under UV Secondary Screening Colorimet- ric - PNP-ester substrates (C2, C4, C18); Substrate, Temperature and pH Profiling 16S ribosomal RNA gene (DNA level) Amidase ATP-dependant protease Beta...

Aprenentatge mòbil de llengües basat en criteris pedagògics

Directory of Open Access Journals (Sweden)

Rafael Seiz Ortiz

2015-12-01

Full Text Available El MALL (Mobile Assisted Language Learning aporta una immensa quantitat d'aplicacions d'aprenentatge de llengües. En aquest context cal que el triple procés d'anàlisi, avaluació i desenvolupament d'aplicacions de MALL compleixi amb dues premisses fonamentals. En primer lloc, s'ha de dur a terme en base a criteris pedagògics específics de l'aprenentatge de llengües. En segon lloc, ha de recolzar-se en models teòrics que consideren el procés d'ensenyament-aprenentatge de llengües. Aquest treball s'emmarca dins d'una investigació més general que proposa una metodologia per a l'anàlisi, avaluació i desenvolupament pedagògic d'aplicacions mòbils d'aprenentatge de llengües, en base a les dues necessitats esmentades. El treball presenta dos resultats d'aquesta investigació general, consistents en la proposta d'un model teòric per al MALL, d'una banda, i en la creació d'una plantilla o rúbrica per facilitar l'anàlisi, l'avaluació i el desenvolupament d'aplicacions MALL específiques. En primer lloc, s'ha proposat un model teòric d'estudi del MALL. Seguidament, s'ha elaborat una plantilla que incorpora paràmetres observables que serveixen per a la descripció, l'avaluació i el desenvolupament pedagògic de recursos per a l'aprenentatge de llengües assistit per tecnologies mòbils.

Gonadal function and fertility after stem cell transplantation in childhood: comparison of a reduced intensity conditioning regimen containing melphalan with a myeloablative regimen containing busulfan.

Science.gov (United States)

Panasiuk, Anna; Nussey, Stephen; Veys, Paul; Amrolia, Persis; Rao, Kanchan; Krawczuk-Rybak, Maryna; Leiper, Alison

2015-09-01

The occurrence of late sequelae after myeloablative conditioning regimens for stem-cell transplantation (SCT) has prompted the introduction of reduced-intensity chemotherapy (RIC) regimens in an attempt to reduce toxicity and spare fertility. We retrospectively evaluated gonadal function in survivors of SCT in childhood by comparing patients conditioned with a myeloablative regimen containing busulfan and cyclophosphamide (BuCy, N = 51, 28 boys) and a RIC regimen containing fludarabine and melphalan (FluMel, N = 40, 19 boys). Spontaneous puberty occurred in 56% of girls and 89% of boys after BuCy, whereas 90% of females and all males in the FluMel group entered puberty spontaneously (P = 0·012). Significantly more females (61%) conditioned with BuCy required hormone replacement compared with the FluMel group (10·5%, P = 0·012). Females in the FluMel group took significantly longer to develop elevation of serum follicle-stimulating hormone (FSH) concentrations (>10 iu/l) from the onset of puberty than females in the BuCy group (median 5·2 years vs. 2·7 years respectively, P = 0·0135). In males no difference was noted between the two conditioning groups in time to FSH elevation (median 4 years in FluMel versus 6 years in BuCy). Whilst the two regimens have similar effects on the testis, ovarian function seems to be better preserved in females undergoing SCT with RIC. © 2015 John Wiley & Sons Ltd.

Spatially Resolved Two-Color Diffusion Measurements in Human Skin Applied to Transdermal Liposome Penetration

DEFF Research Database (Denmark)

Brewer, Jonathan; Bloksgaard, Maria; Kubiak, Jakub

2013-01-01

A multiphoton excitation-based fluorescence fluctuation spectroscopy method, Raster image correlation spectroscopy (RICS), was used to measure the local diffusion coefficients of distinct model fluorescent substances in excised human skin. In combination with structural information obtained by mu......; doi:10.1038/jid.2012.461....

A novel mutation in the AGXT gene causing primary hyperoxaluria ...

Indian Academy of Sciences (India)

synthesis of an aberrant gene product (Williams et al. 2009). Wild-type AGXT .... The urinary oxalate excretion was assayed by a colorimet- ric enzymatic method in ... ure, with clearance = 70 mL/min per 1.73 m2, urea = 7 mmol/L, creatinine ...

Katse portreteerida nõukogude kosmosemaja / Mait Väljas

Index Scriptorium Estoniae

Väljas, Mait

2011-01-01

Prantsuse fotograafist Frédéric Chaubinist, kes pildistas NSV Liidus 1975.-1990. a. ehitatud eripäraseid hooneid, korraldas fotonäitusi. F. Chaubini raamatust "СССР : cosmic communist constructions photographed" (Köln : Taschen, 2011), raamatusse jõudnud eesti arhitektuurist

El espejo europeo

Directory of Open Access Journals (Sweden)

Jorge Orlando Melo

2001-01-01

Full Text Available El nacionalismo cosmopolita. La referencia europea en la construcción nacional en Colombia, 1845-1900. Frédéric Martínez. Banco de la República, Instituto Francés de Estudios Andinos, Bogotá, 2001, 580 págs.

A Statistical Procedure for Assessing Test Dimensionality.

Science.gov (United States)

1984-03-09

Office of Scientific Research I Military Assistant for Training and Life Sciences Directorate, NL Personnel Technology Bolling Air Force Base Office of...DEPARTIINT University of Tennessee UIVERSITY OF KANSAS XKoxvlle, TN 37936 Lawrence, KS 66045 I Dr. John 1. Carroll I RIC Facility-Acquisitions 409 Elliott Rd

First report of tomato chlorotic spot virus in non-solanaceous weeds erect spiderling (Boerhavia erecta) and asian spiderflower (Cleome viscosa), and sweet chili pepper (Capsicum chinense) in Puerto Rico

Science.gov (United States)

Tomato chlorotic spot virus (TCSV) has recently been detected in tomato, bell pepper, jimsonweed and lettuce in Puerto Rico. Observations of weeds and additional crops in 2015 and 2016 revealed TCSV-like symptoms. Testing of these symptomatic plants identified three new hosts of TCSV in Puerto Ric...

United States Coast Guard Antisubmarine Warfare (ASW) in the Maritime Defense Zone (MDZ) - A Strategic Approach

Science.gov (United States)

1989-03-01

RIC ILE COPY AIR WAR COLLGE REEAC R~pCR UNITED STATES COAST GUARD ANTISUBMARINE WARFARE (ASW) IN THE MARITIME DEFENSE ZONE (MDZ) -A STRATEGIC...going to perform in these MDZs. Those tasks identified so far include: port and coastal physical security & preventive safety, mine warfare

Corrigendum to "Ocean acidification effect on prokaryotic metabolism tested in two diverse trophic regimes in the mediterranean sea" [Estuar. Coast shelf sci. 186 (2017) 125-138

Science.gov (United States)

Celussi, Mauro; Malfatti, Francesca; Annalisa, Franzo; Gazeau, Frédéric; Giannakourou, Antonia; Pitta, Paraskevi; Tsiola, Anastasia; Del Negro, Paola

2018-03-01

The authors regret for the wrong order of the name/surname of the third author. The correct list of authors is therefore as follows: Mauro Celussia,∗, Francesca Malfattia, Annalisa Franzoa, Frédéric Gazeaub,c, Antonia Giannakouroud, Paraskevi Pittae, Anastasia Tsiolae, Paola Del Negroa.

Sampling variability in forensic likelihood-ratio computation: A simulation study

NARCIS (Netherlands)

Ali, Tauseef; Spreeuwers, Lieuwe Jan; Veldhuis, Raymond N.J.; Meuwly, Didier

2015-01-01

Recently, in the forensic biometric community, there is a growing interest to compute a metric called “likelihood- ratio‿ when a pair of biometric specimens is compared using a biometric recognition system. Generally, a biomet- ric recognition system outputs a score and therefore a likelihood-ratio

Testimony, Memory and Solidarity across National Borders: Paul Ricoeur and Transnational Feminism

Directory of Open Access Journals (Sweden)

Elizabeth Purcell

2017-07-01

Full Text Available In many ways, globalization created the problem of representation for feminist solidarity across the borders of the nation state. This problem is one of presenting a cohesive identity for representation in the transnational public sphere. This paper proposes a solution to this problem of a cohesive identity for women’s representation by drawing on the work of Paul Ricœur. What these women seem to have in common are shared political aims, but they have no basis for those aims. This paper provides a basis for these aims by turning to Ricœur’s work on collective memory from Memory, History, Forgetting. The paper concludes that it is the shared testimony through narrative hospitality, which can provide a foundation for a social bond for those with common political aims. More specifically, this common knowledge provides a justification for the representation of women and their allies in the transnational public sphere.

An Innovative Reconfigurable Integrated Converter Topology Suitable for Distributed Generation

Directory of Open Access Journals (Sweden)

Renato Rizzo

2012-09-01

Full Text Available The electricity market and environmental concerns, with wide utilization of renewable sources, have improved the diffusion of distributed generation units changing the operations of distribution grids from passive networks to microgrids. A microgrid includes a cluster of electrical loads, energy storage devices and microsources, which provide both power and heat to their local area. A microgrid has usually one connection point to the utility grid through power electronic converters placed at customers’ sites. This paper analyses a Reconfigurable Integrated Converter (RIC used for a domestic microgrid with inputs from the AC mains and photovoltaic arrays, and two DC outputs at different voltage levels. A RIC as a dual-boost DC-DC converter is proposed, modelled and analysed in the paper. The advantages of such a topology in comparison with traditional boost converters are outlined. Reported simulations results give evidence on the controllability of this converter and the capability of achieving the desired voltage outputs with reduced ripple.

Uniform bounds of the spectrum of Dirac operators

International Nuclear Information System (INIS)

Ezin, J.P.; Rigoli, M.

1988-06-01

Let (M,g) be a compact, connected Riemannian manifold of dimension n ≥ 3. We denote with Ric g , S g and γ the Ricci curvature, the scalar curvature and conformal class of g, respectively. Then using techniques introduced by A. Lichnerowicz we present a proof of Hijazi's following result. If S g ≥ 0 and (M,g) is a spin manifold, there is a constant μ ≥ 0, depending only on n and γ, such that every eigenvalue λ of the Dirac operator acting on spinor fields over M satisfies λ 2 vol(M,g) 2/n ≥μ. In an appendix we prove that if S g is constant and (M,g) is not conformally diffeomorphic to a standard n-sphere, then if γ contains another metric with constant scalar curvature, there is a positive function ρ on M such that (Ric - Sg / n g) (∇ρ, ∇ρ) is negative somewhere on M. (author). 12 refs

REDES DE INTERCAMBIO DE CALOR APLICADAS A LA ESTERIFICACIÓN DE ACEITES VEGETALES USADOS

Directory of Open Access Journals (Sweden)

María F. Laborde

2014-01-01

Full Text Available E n este trabajo se presenta la aplicación de redes de intercambio de calor (RIC a la esterificación de aceites vegetales usados (AVUs con catálisis ácida para la producción de biodiesel. Se aplican distintos métodos para obtener las cantidades mínimas de calor y la RIC para una capacidad de procesamiento de 0,19 kg/s de AVUs. Se considera una diferencia de temperatura mínima (∆Tmin de 10°C y los requerimientos mínimos de calentamiento y enfriamiento, resultan ser de 4629,87 W y de 10066,30 W, respectivamente. Al aplicar la red de intercambio calórico disminuye en un 78,92% el servicio de vapor requerido en el proceso y en un 62,48% el servicio de agua de enfriamiento, lo que demuestra que la integración reduce los requerimientos energéticos respecto al proceso no integrado.

Acquiring a taste for the Higgs boson

CERN Multimedia

Caroline Duc

2012-01-01

Before CERN's scientists had even announced the discovery of the Higgs boson, others were already attributing some interesting characteristics to it: flavoursome, sparkling and liquid...   The artisan brewery Hopfenstark in Quebec launched its new "Higgs boson" beer in November 2010. Ever since, it has been intriguing enthusiasts with its unique taste explosion. The boson was a source of inspiration for brewer Frédéric Cormier, the Hopfenstark brewery's owner, who is a big fan of science programmes. "I returned from a trip to Europe in 2010 with the idea for a new beer that would be unlike any other," he explains. "I was always reading and hearing about CERN's particle accelerator in the media, so I did some research on the famous Higgs boson and decided to give my new creation the same name." For Frédéric Cormier, it's important that the names of his beers refle...

mTORC2 Regulation of Muscle Metabolism and Insulin Sensitivity

DEFF Research Database (Denmark)

Kleinert, Maximilian

and skeletal muscle to take up blood glucose, ultimately lowering blood glucose levels. A hallmark of T2D is decreased organ sensitivity to the effects of the insulin. Therefore, an early event in the pathogenesis of T2D is an increase in insulin secretion in response to eating a meal, as more insulin....... In the absence of insulin, the majority of GLUT4 resides within the muscle. Conversely, insulin stimulation increases the muscle’s permeability to glucose, by triggering GLUT4 translocation to the plasma membrane. The effect of insulin on GLUT4 translocation is mediated by a chain of molecular signaling events...... that mTORC2 controls skeletal muscle glycolysis and lipid storage. In agreement, Ric mKO mice exhibited reduced muscle glycolytic flux, greater reliance on fat as an energy substrate, re-partitioning of lean to fat mass and higher intramyocellular triacylglycerol (IMTG) levels compared to Ric WT mice...

Entretien sur la psychanalyse: réflexions en marge

Directory of Open Access Journals (Sweden)

Giuseppe Martini

2016-08-01

Full Text Available L’auteur propose ici un commentaire sur les points les plus importants de son entretien de février 2003 avec Paul Ricœur consacré aux rapports entre herméneutique et psychanalyse. Bien que le philosophe se situe dans une réelle continuité par rapport à sa contribution de 1965, il enrichit toutefois sa réflexion philosophique sur la psychanalyse en proposant plusieurs innovations, en ce qui concerne plus particulièrement les thèmes du récit, du soi et de l’éthique. Dans les conclusions de son commentaire, l’auteur souligne l’importance des concepts d’“irreprésentable” et d’“intraduisible”: non seulement, en effet, ces concepts sont dans la ligne de nombreuses contributions de la psychanalyse contemporaine, mais la profondeur de la réflexion ricœurienne augmente en outre leur potentiel théorique et même clinique.

Negative Correlation between the Diffusion Coefficient and Transcriptional Activity of the Glucocorticoid Receptor.

Science.gov (United States)

Mikuni, Shintaro; Yamamoto, Johtaro; Horio, Takashi; Kinjo, Masataka

2017-08-25

The glucocorticoid receptor (GR) is a transcription factor, which interacts with DNA and other cofactors to regulate gene transcription. Binding to other partners in the cell nucleus alters the diffusion properties of GR. Raster image correlation spectroscopy (RICS) was applied to quantitatively characterize the diffusion properties of EGFP labeled human GR (EGFP-hGR) and its mutants in the cell nucleus. RICS is an image correlation technique that evaluates the spatial distribution of the diffusion coefficient as a diffusion map. Interestingly, we observed that the averaged diffusion coefficient of EGFP-hGR strongly and negatively correlated with its transcriptional activities in comparison to that of EGFP-hGR wild type and mutants with various transcriptional activities. This result suggests that the decreasing of the diffusion coefficient of hGR was reflected in the high-affinity binding to DNA. Moreover, the hyper-phosphorylation of hGR can enhance the transcriptional activity by reduction of the interaction between the hGR and the nuclear corepressors.

Linear and nonlinear optical properties of multilayered spherical quantum dots: Effects of geometrical size, hydrogenic impurity, hydrostatic pressure and temperature

International Nuclear Information System (INIS)

Karimi, M.J.; Rezaei, G.; Nazari, M.

2014-01-01

Based on the effective mass and parabolic one band approximations, simultaneous effects of the geometrical size, hydrogenic impurity, hydrostatic pressure, and temperature on the intersubband optical absorption coefficients and refractive index changes in multilayered spherical quantum dots are studied. Energy eigenvalues and eigenvectors are calculated using the fourth-order Runge–Kutta method and optical properties are obtained using the compact density matrix approach. The results indicate that the hydrogenic impurity, hydrostatic pressure, temperature and geometrical parameters such as the well and barrier widths have a great influence on the linear, the third-order nonlinear and the total optical absorption coefficients and refractive index changes. -- Highlights: • Hydrogenic impurity effects on the optical properties of a MSQD are investigated. • Hydrostatic pressure and temperature effects are also studied. • Hydrogenic impurity has a great influence on the linear and nonlinear ACs and RICs. • Hydrostatic pressure and temperature change the linear and nonlinear ACs and RICs

Arquitectura y Documentos. Mapa documental para el estudio de la arquitectura y las obras de Carlos Arniches

Directory of Open Access Journals (Sweden)

Concha Diez-Pastor

2017-10-01

dels fets. Investigacions prèvies sobre aquests arquitectes van posar de manifest la rellevància de l’autoria a l’hora d’analitzar les obres d’arquitectura, suggerint la conveniència d’aprofundir en aquella via d’investigació que, finalment, va abastar gairebé la totalitat de la seva obra. Abans de 1936, Arncihes i Domínguez havien treballat en algunes obres com a socis. No obstant això, com demostren les proves i documents d’arxiu, no totes les seves obres van ser conjuntes, i les que ho bvan ser no sempre es van atribuir degudament al seu autor real, com es dedueix dels documents. El context, clau per entendre el material documental i d’arxiu recaptat, i la exhaustiva avaluació que inclou els punts de vista històric i cultural, desvetllen l’autoria real, permetent assentar els fets i preservar els seus valors i el seu abast històric..

Remediation of context-processing deficits in schizophrenia: preliminary data with ambiguous sentences

Directory of Open Access Journals (Sweden)

Besche-Richard C

2014-12-01

Full Text Available Chrystel Besche-Richard,1,2 Sarah Terrien,1 Marion Lesgourgues,3,4 Célia Béchiri-Payet,5 Fabien Gierski,1,3 Frédéric Limosin6–8 1Laboratory Cognition, Santé, Socialisation, University of Reims Champagne-Ardenne, France; 2Institut Universitaire de France, Paris, France; 3Centre Hospitalier Universitaire, Pôle de Psychiatrie des Adultes, Reims, France; 4Service Universitaire de Médecine Préventive et de Promotion de la Santé, University of Reims Champagne-Ardenne, Reims, France; 5Etablissement Public de Santé mentale départemental de l’Aisne, Prémontré, France; 6Department of Adult and Geriatric Psychiatry, Hôpitaux Universitaires Paris, Ouest (Assistance publique-Hôpitaux de Paris, Hôpital Corentin-Celton, Issy-les-Moulineaux, France; 7Faculty of Medicine, University Paris Descartes, Sorbonne Paris Cité, Paris, France; 8Psychiatry and Neurosciences Center, French National Institute of Health and Medical Research, Institut National de la Santé et de la Recherche Médicale U894, Paris, France Background: Processing of contextual information is essential for the establishment of good interpersonal relations and communicational interactions. Nevertheless, it is known that schizophrenic patients present impairments in the processing of contextual information. The aim of this study is to explore the influence of the remediation of context processing in schizophrenic patients. Methods: Thirty-one schizophrenic patients and 28 matched healthy participants were included in this study. All participants were assessed on verbal knowledge (Mill-Hill test and depression intensity (Beck Depression Scale 21 items. Schizophrenic patients were also assessed on thought, language, and communication disorders (Thought, Language and Communication scale. All participants completed a disambiguation task with two different levels of contextualization (high or low context and a context-processing remediation task containing social scenarios that

The emerging land management paradigm

DEFF Research Database (Denmark)

Enemark, Stig

2006-01-01

Manchet: This paper was first presented by Professor Enemark at the RICS Christmas Lecture in December last year. It provides a cogent and detailed reference point for the current state of land management in developed countries, charts a course for the future and looks at how education must chang...

Dr Jung Hyun KIM Vice Minister for Education, Science and Technology MEST Republic of Korea

CERN Multimedia

Jean-Claude Gadmer

2010-01-01

He learnt about CERN's LHC computing grid project from Frédéric Hemmer, head of the information technology department. In addition, the vice-minister toured the ATLAS visitor centre, the CMS control centre, the ALICE experiment's exhibition and control room, and he met Korean scientists at CERN.

U.S. EPA, Pesticide Product Label, PROKIL PARATHION 4 LB, 01/06/1988

Science.gov (United States)

2011-04-21

... m:AIl [lmRE l.ARD .. II,.> "Ilirtly III acca,· .Irlll':a with dUllyers. ... f .• ,ricI'!'lIHII r.xlen~inn ;'l'rvIU~ ·(I.,ePII""I. ~:' . lhL· I.Sl::le. BEANS: "'I,hid~i. r;.!oi'f1·lli'.;. ...

El rastre dels més desvalguts entre els papers de l'Hospital de Barcelona

Directory of Open Access Journals (Sweden)

Teresa Vinyoles Vidal

2013-12-01

Full Text Available Aquest text, que té el seu origen en la ponència que vam presentar al simposi internacional Fonts gràfiques i documentals per a l’estudi històric dels hospitals (abril 2013, pretén oferir un petit mostrari de la informació que es pot extreure i les conclusions que se’n deriven, de la consulta directa de les fonts documentals de l’antic hospital de la Santa Creu de Barcelona. El punt de partida de la nostra recerca s’emmarca en els mateixos orígens històrics d’aquesta centenària institució, és a dir, l’albada del segle XV. En aquest sentit, bàsicament hem fet servir els llibres d’entrades de malalts i d’expòsits, un minutari comptable i uns manuals notarials del quatre-cents i d’èpoques posteriors, conservats a la Biblioteca de Catalunya i a l’Arxiu Històric de la Fundació de l’Hospital de la Santa Creu i Sant Pau. El nostre propòsit no és fer-ne un estat de la qüestió, ni esbossar una història de la pobresa barcelonina, ni tampoc plantejar una visió comparativa de les institucions hospitalàries, senzillament, després de reflexionar sobre el tema, mirarem de dialogar amb les fonts i que siguin elles les que parlin. Procurarem, en el possible, sentir la veu dels pobres del passat, però sense oblidar que la pobresa no és propietat exclusiva dels temps medievals.

Technical note: Validation of an automated system for monitoring and restricting water intake in group-housed beef steers.

Science.gov (United States)

Allwardt, K; Ahlberg, C; Broocks, A; Bruno, K; Taylor, A; Place, S; Richards, C; Krehbiel, C; Calvo-Lorenzo, M; DeSilva, U; VanOverbeke, D; Mateescu, R; Goad, C; Rolf, M M

2017-09-01

The Insentec Roughage Intake Control (RIC) system has been validated for the collection of water intake; however, this system has not been validated for water restriction. The objective of this validation was to evaluate the agreement between direct observations and automated intakes collected by the RIC system under both ad libitum and restricted water conditions. A total of 239 crossbred steers were used in a 3-d validation trial, which assessed intake values generated by the RIC electronic intake monitoring system for both ad libitum water intake ( = 122; BASE) and restricted water intake ( = 117; RES). Direct human observations were collected on 4 Insentec water bins for three 24-h periods and three 12-h periods for BASE and RES, respectively. An intake event was noted by the observer when the electronic identification of the animal was read by the transponder and the gate lowered, and starting and ending bin weights were recorded for each intake event. Data from direct observations across each validation period were compared to automated observations generated from the RIC system. Missing beginning or ending weight values for visual observations occasionally occurred due to the observer being unable to capture the value before the monitor changed when bin activity was high. To estimate the impact of these missing values, analyses denoted as OBS were completed with the incomplete record coded as missing data. These analyses were contrasted with analyses where observations with a single missing beginning or end weight (but not both) were assumed to be identical to that which was recorded by the Insentec system (OBS). Difference in mean total intake across BASE steers was 0.60 ± 2.06 kg OBS (0.54 ± 1.99 kg OBS) greater for system observations than visual observations. The comparison of mean total intake across the 3 RES validation days was 0.53 ± 2.30 kg OBS (0.13 ± 1.83 kg OBS) greater for system observations than direct observations. Day was not a

78 FR 6847 - Proposed Collection; Comment Request for Information Collection Tools

Science.gov (United States)

2013-01-31

... approved by OMB. Type of Review: Extension of a currently approved collection. Affected Public: Business or... information technology; and (e) estimates of capital or start-up costs and costs of operation, maintenance... Section 1(h) of the Internal Revenue Code (Applying Section 1(h) to Capital Gain Dividends of RICs and...

Resenha de: Le XVIe siècle européen: aspects économiques

Directory of Open Access Journals (Sweden)

Eurípedes Simões de Paula

1967-03-01

Full Text Available MAURO (Frédéric . — Le XVIe siècle européen. Aspects économiques. Paris. Presses Universitaires de France. Coleção "Nouvelle Clio". 1 volume de 13,5 x 18 cm. 392 páginas, 14 mapas e gráficos.

Making Biology Relevant to Undergraduates

Science.gov (United States)

Musante, Susan

2012-01-01

This article features Science Education for New Civic Engagements and Responsibilities (SENCER; www.sencer.net) Summer Institute. The SENCER program, which began formally in 2001, was the vision of David Burns; Karen Oates, currently Peterson Family Dean of Arts and Sciences at Worcester Polytechnic Institute; and Ric Wiebl, currently director of…

Reconsidering evil : confronting Reflections with Confessions

NARCIS (Netherlands)

Schaafsma, Esther Petruschka

2006-01-01

The notion of evil is not undisputed in contemporary philosophy and theology. Reconsidering Evil attempts a regauging of this notion by comparing four different approaches to the theme of evil. Paul Ricœur’s approach via symbols of evil provides a focus that enables an analysis and comparison of the

ADVANCED VITRIFICATION SYSTEM (RIC AVS) RESEARCH AND DEVELOPMENT PROJECT

Energy Technology Data Exchange (ETDEWEB)

J.R. Powell; M. Reich

2003-06-30

The objective of this AVS testing program is to use bench-scale test equipment to produce a vitrified product at maximum waste loading from the specified AZ-101 waste simulant and conduct a TTT analysis using laboratory scale melts to show compliance with the DOE Waste Acceptance Product Specifications for Vitrified High-Level Waste Forms (WAPS). The vitrified product complies with the following WAPS. A borosilicate glass with a waste loading of 60.9-wt% was produced from a slurry feed of AZ101 simulant. Glass durability testing, glass characterization testing, and testing methodology were performed in accordance with the Department of Energy approved Test Plan. The glass has two crystalline phases and good uniformity of composition. The Product Consistency Test on the 6 location-specific samples are at least 1 to 2 orders of magnitude below the mean PCT results for the EA glass. Standard deviations were less than 10% of measured values. The glass transition temperature averaged 658 {+-} 9 C. A TTT diagram was produced. There was measured cesium loss of about 2%, and compliance with the Universal Treatment Standards.

ADVANCED VITRIFICATION SYSTEM (RIC AVS) RESEARCH AND DEVELOPMENT PROJECT

International Nuclear Information System (INIS)

Powell, J.R.; Reich, M.

2003-01-01

The objective of this AVS testing program is to use bench-scale test equipment to produce a vitrified product at maximum waste loading from the specified AZ-101 waste simulant and conduct a TTT analysis using laboratory scale melts to show compliance with the DOE Waste Acceptance Product Specifications for Vitrified High-Level Waste Forms (WAPS). The vitrified product complies with the following WAPS. A borosilicate glass with a waste loading of 60.9-wt% was produced from a slurry feed of AZ101 simulant. Glass durability testing, glass characterization testing, and testing methodology were performed in accordance with the Department of Energy approved Test Plan. The glass has two crystalline phases and good uniformity of composition. The Product Consistency Test on the 6 location-specific samples are at least 1 to 2 orders of magnitude below the mean PCT results for the EA glass. Standard deviations were less than 10% of measured values. The glass transition temperature averaged 658 ± 9 C. A TTT diagram was produced. There was measured cesium loss of about 2%, and compliance with the Universal Treatment Standards

1579-IJBCS- Article-Frédéric Houndonougbo

African Journals Online (AJOL)

hp

Les performances de ponte et la qualité des œufs de 216 poules pondeuses ISA Brown âgées de 21 semaines ont été déterminées en les alimentant avec des rations contenant des feuilles séchées de manioc. (Manihot esculenta, Crantz). Pendant douze semaines, trois groupes de 72 poules chacun (réparties en trois.

Browse Title Index

African Journals Online (AJOL)

AM Quilez, S Montserrat-de la Paz, R De la Puerta, MA Fernandez-Arche, MD Gargia-Gimenez ... Danubia C. Sá-Caputo, Carla da F. Dionello, Éric Heleno F.F. Frederico, Laisa L. Paineiras-Domingos, Cintia Renata Sousa-Gonçalves, Danielle S. Morel, Eloá Moreira-Marconi, Marianne Unger, Mario Bernardo-Filho.

77 FR 23806 - Submission for OMB Review; Comment Request

Science.gov (United States)

2012-04-20

...- determinations made by a regulated investment company (RIC) or a real estate investment trust (REIT). IRC section...--Miscellaneous Sections Affected by the Taxpayer Bill of Rights 2 and the Personal Responsibility and Work... and certain fees. The regulations reflect changes to the law made by the Taxpayer Bill of Rights 2 and...

Discontinuité et cohésion dans Vivre pour la raconter de Gabriel García Márquez

DEFF Research Database (Denmark)

Jensen, Julio Hans C.

2017-01-01

The present contribution aims at analyzing Gabriel García Márquez’s autobiographical work Vivir para contarla (Living to Tell the Tale) using psychoanalytic theory and Paul Ricœur’s notion of subjectivity (Soi-même comme un autre / Oneself as Another). By means of the analysis, Vivir para contarla...

Delacroix

DEFF Research Database (Denmark)

Indhold: Anne-Birgitte Fonsmark: Delacroix : maleriets musik. Vincent Pomarède: Frédéric Chopin og George Sand : to portrætter af Eugène Delacroix ; "De tavse kunstarter" og musikken : Eugène Delacroix, en musikelskende maler. Thomas Lederballe: Delacroix' entusiasme : bortførelsen som genre i hans...

Short notes and reviews Amphibians of France, Belgium and Luxemburg

NARCIS (Netherlands)

Vences, Miguel

2004-01-01

As a general trend, accounts on regional and local herpetofaunas tend to become more and more colourful and extensive, and the classical borders between fieldguide, distribution atlas and handbook are fading. The book reviewed here is a good example for this trend. Edited by Rémi Duguet und Frédéric

Development of site index curves for Pinus kesiya in the Philippines ...

African Journals Online (AJOL)

Development of site index curves for Pinus kesiya in the Philippines. RIC Lumbres, YJ Lee, YO Seo, FG Calora JR. Abstract. This study was conducted to develop a height–age growth model and site index curves for site quality evaluation of old secondary-growth stands of Pinus kesiya in the northern Philippines.

Reappraising the P–T evolution of the Rogaland–Vest Agder Sector, southwestern Norway

Directory of Open Access Journals (Sweden)

Eleanore Blereau

2017-01-01

Full Text Available The Rogaland–Vest Agder Sector of southwestern Norway comprises high-grade metamorphic rocks intruded by voluminous plutonic bodies that include the ∼1000 km2 Rogaland Igneous Complex (RIC. New petrographic observations and thermodynamic phase equilibria modelling of three metapelitic samples collected at various distances (30 km, 10 km and ∼10 m from one of the main bodies of RIC anorthosite were undertaken to assess two alternative P–T–t models for the metamorphic evolution of the area. The results are consistent with a revised two-phase evolution. Regional metamorphism followed a clockwise P–T path reaching peak conditions of ∼850–950 °C and ∼7–8 kbar at ∼1035 Ma followed by high-temperature decompression to ∼5 kbar at ∼950 Ma, and resulted in extensive anatexis and melt loss to produce highly residual rocks. Subsequent emplacement of the RIC at ∼930 Ma caused regional-scale contact metamorphism that affected country rocks 10 km or more from their contact with the anorthosite. This thermal overprint is expressed in the sample proximal to the anorthosite by replacement of sillimanite by coarse intergrowths of cordierite plus spinel and growth of a second generation of garnet, and in the intermediate (10 km sample by replacement of sapphirine by coarse intergrowths of cordierite, spinel and biotite. The formation of late biotite in the intermediate sample may suggest the rocks retained small quantities of melt produced by regional metamorphism and remained at temperatures above the solidus for up to 100 Ma. Our results are more consistent with an accretionary rather than a collisional model for the Sveconorwegian Orogen.

Dual energy spectral CT imaging for the evaluation of small hepatocellular carcinoma microvascular invasion.

Science.gov (United States)

Yang, Chuang-Bo; Zhang, Shuang; Jia, Yong-Jun; Yu, Yong; Duan, Hai-Feng; Zhang, Xi-Rong; Ma, Guang-Ming; Ren, Chenglong; Yu, Nan

2017-10-01

To study the clinical value of dual-energy spectral CT in the quantitative assessment of microvascular invasion of small hepatocellular carcinoma. This study was approved by our ethics committee. 50 patients with small hepatocellular carcinoma who underwent contrast enhanced spectral CT in arterial phase (AP) and portal venous phase (VP) were enrolled. Tumour CT value and iodine concentration (IC) were measured from spectral CT images. The slope of spectral curve, normalized iodine concentration (NIC, to abdominal aorta) and ratio of IC difference between AP and VP (RIC AP-VP : [RIC AP-VP =(IC AP -IC VP )/IC AP ]) were calculated. Tumours were identified as either with or without microvascular invasion based on pathological results. Measurements were statistically compared using independent samples t test. The receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of tumours microvascular invasion assessment. The 70keV images were used to simulate the results of conventional CT scans for comparison. 56 small hepatocellular carcinomas were detected with 37 lesions (Group A) with microvascular invasion and 19 (Group B) without. There were significant differences in IC, NIC and slope in AP and RIC AP-VP between Group A (2.48±0.70mg/ml, 0.23±0.05, 3.39±1.01 and 0.28±0.16) and Group B (1.65±0.47mg/ml, 0.15±0.05, 2.22±0.64 and 0.03±0.24) (all phepatocellular carcinoma with and without microvascular invasion. Quantitative iodine concentration measurement in spectral CT may be used to provide a new method to improve the evaluation for small hepatocellular carcinoma microvascular invasion. Copyright © 2017 Elsevier B.V. All rights reserved.

Anti-viral effects of medicinal plants in the management of dengue: a ...

African Journals Online (AJOL)

Anti-viral effects of medicinal plants in the management of dengue: a systematic review. Éric Heleno Freira Ferreira Frederico, André Luiz Bandeira Dionísio Cardoso, Eloá Moreira-Marconi, Danúbia da Cunha de Sá-Caputo, Carlos Alberto Sampaio Guimarães, Carla da Fontoura Dionello, Danielle Soares Morel, Laisa ...

78 FR 52308 - Harmonization of Compliance Obligations for Registered Investment Companies Required To Register...

Science.gov (United States)

2013-08-22

... Commission's regulatory regime with that of the SEC as it applies to CPOs of RICs is grounded in the concept... key changes from the Proposal that the Commission is making in the rules it is adopting today are as... records; and (3) the signed acknowledgement requirement is being rescinded for all CPOs. The reasoning...

U.S. EPA, Pesticide Product Label, BROGDEX 594-F, 06/08/1984

Science.gov (United States)

2011-04-14

... ric •• .. t ,.1 '~'1 .. ':: 1;1 ), .'dll.)I\\S "f :.'.l1r .. ·,1 -1llut 1 .. 0 ,I fH,I~,jCX )vi) ~~"tI~C .... dX fur lu".) pp:n Hll .. 11.:> ~CI)l~n. USC b ~un~e. ut Sr~~J~x ...

Fulltext PDF

Indian Academy of Sciences (India)

KSH Newton Singh

2017-07-11

Jul 11, 2017 ... solution describing a spinning black hole, the Kerr met- ric, is of class V [6]. Embedding class of space took vital role in describing the internal symmetry of ele- mentary particle physics [7]. Pavsic and Tapia [8] have discussed the applications of embedding solution to gen- eral relativity, extrinsic gravity, ...

Evaluating the Effects of Clothing and Individual Equipment on Marksmanship Performance Using a Novel Five Target Methodology

Science.gov (United States)

2016-11-01

operationally relevant and address the key factors for Warfighter performance. N ot s ub je ct to U .S . c op yr ig ht re st ric tio ns . D...11B) from the 75th Ranger Regiment. Two TPs were Aberdeen Test Center (ATC) Contractors as Representative Soldiers (CARS). One of the CARS is

Spatiotemporal visualization of subcellular dynamics of carbon nanotubes

KAUST Repository

Serag, Maged F.

2012-12-12

To date, there is no consensus on the relationship between the physicochemical characteristics of carbon nanotubes (CNTs) and their biological behavior; however, there is growing evidence that the versatile characteristics make their biological fate largely unpredictable and remain an issue of limited knowledge. Here we introduce an experimental methodology for tracking and visualization of postuptake behavior and the intracellular fate of CNTs based on the spatial distribution of diffusion values throughout the plant cell. By using raster scan image correlation spectroscopy (RICS), we were able to generate highly quantitative spatial maps of CNTs diffusion in different cell compartments. The spatial map of diffusion values revealed that the uptake of CNTs is associated with important subcellular events such as carrier-mediated vacuolar transport and autophagy. These results show that RICS is a useful methodology to elucidate the intracellular behavior mechanisms of carbon nanotubes and potentially other fluorescently labeled nanoparticles, which is of relevance for the important issues related to the environmental impact and health hazards. © 2012 American Chemical Society.

Updates on HRF Payloads Operations in Columbus ATCS

Science.gov (United States)

DePalo, Savino; Wright, Bruce D.; La,e Robert E.; Challis, Simon; Davenport, Robert; Pietrafesa, Donata

2011-01-01

The NASA developed Human Research Facility 1 (HRF1) and Human Research Facility (HRF2) experiment racks have been operating in the European Space Agency (ESA) Columbus module of the International Space Station (ISS) since Summer 2008. The two racks are of the same design. Since the start of operations, unexpected pressure spikes were observed in the Columbus module's thermal-hydraulic system during the racks activation sequence. The root cause of these spikes was identified in the activation command sequence in the Rack Interface Controller (RIC), which controls the flow of thermal-hydraulic system fluid through the rack. A new Common RIC Software (CRS) release fixed the bug and was uploaded on both racks in late 2009. This paper gives a short introduction to the topic, describes the Columbus module countermeasures to mitigate the spikes, describes the ground validation test of the new software, and describes the flight checks performed before and after the final upload. Finally, the new on-orbit test designed to further simplify the racks hydraulic management is presented.

Chromatic, geometric and space charge effects on laser accelerated protons focused by a solenoid

OpenAIRE

Al-Omari, Husam; Hofmann, Ingo; Ratzinger, Ulrich

2011-01-01

We stud­ied nu­mer­i­cal­ly emit­tance and trans­mis­sion ef­fects by chro­mat­ic and ge­o­met­ric aber­ra­tions, with and with­out space charge, for a pro­ton beam be­hind a solenoid in the laser pro­ton ex­per­i­ment LIGHT at GSI. The TraceWin code was em­ployed using a field map for the solenoid and an ini­tial dis­tri­bu­tion with ex­po­nen­tial en­er­gy de­pen­dence close to the ex­per­i­ment. The re­sults show a strong ef­fect of chro­mat­ic, and a rel­a­tive­ly weak one of ge­o­met­ric...

Analysis and Design of Symmetrical Capacitor Diode Voltage Multiplier Driven by LCL-T Resonant Converter

Science.gov (United States)

Malviya, Devesh; Borage, Mangesh Balkrishna; Tiwari, Sunil

2017-12-01

This paper investigates the possibility of application of Resonant Immittance Converters (RICs) as a current source for the current-fed symmetrical Capacitor-Diode Voltage Multiplier (CDVM) with LCL-T Resonant Converter (RC) as an example. Firstly, detailed characterization of the current-fed symmetrical CDVM is carried out using repeated simulations followed by the normalization of the simulation results in order to derive the closed-form curve fit equations to predict the operating modes, output voltage and ripple in terms of operating parameters. RICs, due to their ability to convert voltage source into a current source, become a possible candidate for the realization of current source for the current-fed symmetrical CDVM. Detailed analysis, optimization and design of LCL-T RC with CDVM is performed in this paper. A step by step design procedure for the design of CDVM and the converter is proposed. A 5-stage prototype symmetrical CDVM driven by LCL-T RC to produce 2.5 kV, 50 mA dc output voltage is designed, built and tested to validate the findings of the analysis and simulation.

Tu m'as donné ta boue et j'en ai fait de l'or ou l'écriture poétique en classe de langues est-elle transgression ?

Directory of Open Access Journals (Sweden)

Marie André-Milesi

2015-05-01

Full Text Available Notre propos souhaite éclairer la notion de transgression dans le cadre des cours de langues avec l'aide des outils d'analyse du philosophe humaniste Paul Ricœur. Le jeu sémantique en donnant l'impression aux apprenants de sortir du sillon scolaire permet-il de penser soi-même comme un autre, d'ouvrir des axes de réflexion et de créativité dans le respect du Cadre Européen de Référence pour les Langues ? From rags to riches or transforming mud into gold : how and why poetry writing in the language classroom is a form of transgression? Abstract: Our analysis aims at enriching the notion of transgression with the analytical tools of the philosopher-cum-humanist Paul Ricœur. We may wonder if the semantic work at play with words giving learners the impression to walk out of the commonly established path allows to think oneself as another and to open new vistas for learners in the respect of the Common European Framework of Reference for Languages?

Does Short-term Litter Input Manipulation Affect Soil Respiration and the Carbon-isotopic Signature of Soil Respired CO2

Science.gov (United States)

Cheng, X.; Wu, J.

2016-12-01

Global change greatly alters the quality and quantity of plant litter inputs to soils, and further impacts soil organic matter (SOM) dynamics and soil respiration. However, the process-based understanding of how soil respiration may change with future shift in litter input is not fully understood. The Detritus Input and Removal Treatment (DIRT) experiment was conducted in coniferous forest (Platycladus orientalis (Linn.) Franco) ecosystem of central China to investigate the impact of above- and belowground litter input on soil respiration and the carbon-isotopic signature of soil respired CO2. Short-term (1-2 years) litter input manipulation significantly affected soil respiration, based on annual flux values, soil respiration was 31.9%, 20.5% and 37.2% lower in no litter (NL), no root (NR) and no input (NRNL), respectively, compared to control (CK). Whereas double litter (DL) treatment increased soil respiration by 9.1% compared to CK. The recalcitrance index of carbon (RIC) and the relative abundance of fungi increased under litter removal or root exclusion treatment (NL, NR and NRNL) compared to CK. Basal soil respiration was positively related to liable C and microbial biomass and negatively related to RIC and fungi to bacteria (F: B) ratio. The carbon-isotopic signature of soil respired CO2 enriched under litter removal and no input treatment, and slightly depleted under litter addition treatment compared to CK. Our results suggest that short-term litter input manipulation can affect the soil respiration by altering substrate availability and microbial community structure, and also impact the carbon-isotopic signature of soil respired CO2 possibly duo to change in the component of soil respiration and soil microclimate.

Drug: D03731 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available ric agent ... DG01568 ... MAO inhibitor ... DG01512 ... Monoamine oxidase B inhibitor ... DG01967 ... Antiparkinson agent Cyp... substrate ... DG01644 ... CYP2D6 substrate ... DG01633 ... CYP3A substrate Same as: C07245 ATC code: N04BD01 Chemical group: DG00864 ... Antiparki...nsonian in combination with levodopa/carbidopa MAOB [HSA

The Polysaccharide Capsule of Campylobacter jejuni 81-176 Modulates the Host Immune Response

Science.gov (United States)

2012-12-17

immune response 3 4 Alexander C. Maue1, Krystle L. Mohawk1, David K. Giles*2, Frédéric Poly1, Cheryl 5 P. Ewing1, Yuening Jiao3, Ginyoung Lee3, Zuchao...McGowan, D. Musher , A. Martin and J. 652 Richards. 1998. Phosphorylcholine on the lipooligosaccharide of 653 Haemophilus influnezae contributes to

TRH-receptor mobility and function in intact and cholesterol-depleted plasma membrane of HEK293 cells stably expressing TRH-R-eGFP

Czech Academy of Sciences Publication Activity Database

Brejchová, Jana; Sýkora, Jan; Ostašov, Pavel; Merta, Ladislav; Roubalová, Lenka; Janáček, Jiří; Hof, Martin; Svoboda, Petr

2015-01-01

Roč. 1848, č. 3 (2015), s. 781-796 ISSN 0005-2736 R&D Projects: GA ČR(CZ) GAP207/12/0919 Institutional support: RVO:67985823 ; RVO:61388955 Keywords : cholesterol * TRH-R-eGFP mobility * FRAP * RICS * DPH fluorescence * G protein coupling Subject RIV: CE - Biochemistry; CF - Physical ; Theoretical Chemistry (UFCH-W) Impact factor: 3.687, year: 2015

Shaping 3-D Volumes in Immersive Virtual Environments

DEFF Research Database (Denmark)

Stenholt, Rasmus

of the user’s work in such tasks. This tech- nique is compared to two other techniques, a spherical brush and a box-shaped lasso, in an evaluation which seeks to identify the pros and cons of the tools. The magic wand proves to be faster to use than the other, but only in certain geomet- ric scenarios...

hp Spectral element methods for three dimensional elliptic problems

Indian Academy of Sciences (India)

elliptic boundary value problems on non-smooth domains in R3. For Dirichlet problems, ... of variable degree bounded by W. Let N denote the number of layers in the geomet- ric mesh ... We prove a stability theorem for mixed problems when the spectral element functions vanish ..... Applying Theorem 3.1,. ∫ r l. |Mu|2dx −.

Thank you

CERN Multimedia

We have been deeply touched by the expressions of sympathy and affection from all the friends and colleagues of Frédéric Roussel at CERN. As it is impossible to answer each one, Baptiste, Bénédicte, Guylaine and I would like to express our gratitude to everyone who sent their condolences. Sylvie Roussel

Guidelines for Developing and Inserting Material Properties into the Code 65 Composite Material Database

Science.gov (United States)

2011-12-01

kind of base fiber used Fab-ric uni, stitched, weave, woven roving, textile form, tape, prepreg Laminate Schedu le [0]10 [0]14 [0]36 Manufacturing...roving, textile form, tape, prepreg Laminate Schedule [0]10 [0]14 [0]36 Manufacturing Date 2006 Test Facility/Date 2007 Program of Record AHM&ST...9 Laminate Schedule .......................................................................................................10 Cure

Modification of the Riemann problem and the application for the boundary conditions in computational fluid dynamics

Directory of Open Access Journals (Sweden)

Kyncl Martin

2017-01-01

Full Text Available We work with the system of partial differential equations describing the non-stationary compressible turbulent fluid flow. It is a characteristic feature of the hyperbolic equations, that there is a possible raise of discontinuities in solutions, even in the case when the initial conditions are smooth. The fundamental problem in this area is the solution of the so-called Riemann problem for the split Euler equations. It is the elementary problem of the one-dimensional conservation laws with the given initial conditions (LIC - left-hand side, and RIC - right-hand side. The solution of this problem is required in many numerical methods dealing with the 2D/3D fluid flow. The exact (entropy weak solution of this hyperbolical problem cannot be expressed in a closed form, and has to be computed by an iterative process (to given accuracy, therefore various approximations of this solution are being used. The complicated Riemann problem has to be further modified at the close vicinity of boundary, where the LIC is given, while the RIC is not known. Usually, this boundary problem is being linearized, or roughly approximated. The inaccuracies implied by these simplifications may be small, but these have a huge impact on the solution in the whole studied area, especially for the non-stationary flow. Using the thorough analysis of the Riemann problem we show, that the RIC for the local problem can be partially replaced by the suitable complementary conditions. We suggest such complementary conditions accordingly to the desired preference. This way it is possible to construct the boundary conditions by the preference of total values, by preference of pressure, velocity, mass flow, temperature. Further, using the suitable complementary conditions, it is possible to simulate the flow in the vicinity of the diffusible barrier. On the contrary to the initial-value Riemann problem, the solution of such modified problems can be written in the closed form for some

Total Control: How the Nazis Countered Unconventional Warfare in the Netherlands During World War Two

Science.gov (United States)

2017-05-25

nf lighting and the terror bombing of the cit) uf Ro1tcrd:1111 . the Nctht:rl t111d:. cnpitulntcd and faced un i11crc;L-;ingl) painful Gcmrnn occupnt...34 Registration revcnlcd risk cnicgciries and ··unwnntcd elem ems " wi1hin th<: 0111ch population. Ri-.,k calcg~>rics inclmkd people v. ith -.kills thut

Proceedings of the 1993 Particle Accelerator Conference Held in Washington, DC on May 17-20, 1993. Volume 5

Science.gov (United States)

1994-05-18

stability. o)i-_ =o)- +I +aOc. Summarizing above relations, the net transfer of power per electron with kinetic energy W is written RI ado ;k of d method•. as... Porno . equations (3)XS) in cylindrical[V~ -lA!-]+ (Ip+2q)A coordinates for a general, Le. not necessarily azxiymanet-2a dC ric, beam. It is valid for

Luksuslik ruum kõigile : vestlus arhitekt Anne Lacatoniga = Luxury space for everyone : interview with Anne Lacaton / intervjueerinud Katrin Paadam

Index Scriptorium Estoniae

Lacaton, Anne, 1955-

2013-01-01

Prantsuse arhitekt Anne Lacaton oma büroo (Lacaton & Vassal, Frédéric Druot, 2011) linnaehituslikult uuendusliku projekti järgi ümber ehitatud 1960. aastate korterelamust Tour du Bois-le-Prêtre Pariisis, sotsiaalelamute ehitusest Prantsusmaal, 1960.-1970. aastatel ehitatud elamute taaskasutusega seotud probleemidest, rekonstrueerimise kasulikkusest võrreldes elamu lammutamise ja uuesti ehitamisega, linnas elavatele inimestele paremate elamistingimuste loomisest, linnaplaneerimisest

Climate-sensitive feedbacks between hillslope processes and fluvial erosion in sediment-driven incision models

Science.gov (United States)

Skov, Daniel S.; Egholm, David L.

2016-04-01

Surface erosion and sediment production seem to have accelerated globally as climate cooled in the Late Cenozoic, [Molnar, P. 2004, Herman et al 2013]. Glaciers emerged in many high mountain ranges during the Quaternary, and glaciation therefore represents a likely explanation for faster erosion in such places. Still, observations and measurements point to increases in erosion rates also in landscapes where erosion is driven mainly by fluvial processes [Lease and Ehlers (2013), Reusser (2004)]. Flume experiments and fieldwork have shown that rates of incision are to a large degree controlled by the sediment load of streams [e.g. Sklar and Dietrich (2001), Beer and Turowski (2015)]. This realization led to the formulation of sediment-flux dependent incision models [Sklar and Dietrich (2004)]. The sediment-flux dependence links incision in the channels to hillslope processes that supply sediment to the channels. The rates of weathering and soil transport on the hillslopes are processes that are likely to respond to changing temperatures, e.g. because of vegetation changes or the occurrence of frost. In this study, we perform computational landscape evolution experiments, where the coupling between fluvial incision and hillslope processes is accounted for by coupling a sediment-flux-dependent model for fluvial incision to a climate-dependent model for weathering and hillslope sediment transport. The computational experiments first of all demonstrate a strong positive feedback between channel and hillslope processes. In general, faster weathering leads to higher rates of channel incision, which further increases the weathering rates, mainly because of hillslope steepening. Slower weathering leads to the opposite result. The experiments also demonstrate, however, that the feedbacks vary significantly between different parts of a drainage network. For example, increasing hillslope sediment production may accelerate incision in the upper parts of the catchment, while at

General classification of a normally flat Ric- semi symmetric submanifolds

International Nuclear Information System (INIS)

Mirzoyan, V.A.

2012-01-01

It has been proved that a normally flat submanifold M in Euclidean space En satisfies the condition R(X,Y)Ricci =0 if and only if it is the open part of one of the following submanifolds: (1) normally flat two-dimensional submanifold, (2) normally flat Einstein submanifold (in particular Ricci-flat or locally Euclidean), (3) normally flat semi- Einstein submanifold, (4) normally flat interlacing product of semi-Einstein submanifolds and locally Euclidean submanifold (may be of zero dimension), (5) direct product of the above enumerated classes of submanifolds

An Ethics Of Discomfort: Supplementing Ricœur On Translation

Directory of Open Access Journals (Sweden)

Lisa Foran

2015-07-01

Full Text Available This article compares Paul Ricoeur and Jacques Derrida on the theme of translation and in particular the ethical implications of the different ways in which they approach the untranslatable.  While Ricoeur’s account of translation as linguistic hospitality does offer a model for an ethical encounter with the other, I argue that this account does not go far enough. My central claim is that Ricoeur’s treatment of translation overemphasizes the movement of appropriation and integration.  While it may not be his intention, this emphasis could lead to a certain kind of complacency that would challenge the ethical claims Ricoeur makes in favour of translation as a paradigm.  I propose to supplement Ricoeur’s hospitality with Derrida’s untranslatable, in order to create a situation of constant discomfort thereby guarding against ethical complacency.

L’Espill de Jaume Roig: una lectura mèdica

Directory of Open Access Journals (Sweden)

Jaume Pons Conca

2016-12-01

Full Text Available En moltes ocasions els estudis de l’Espill de Jaume Roig s’han centrat exclusivament en els aspectes misògins de l’obra, la qual cosa ha impedit aprofundir en altres aspectes que, en certa mesura, poden fins i tot alleugerir aquesta càrrega. És per això que ens proposem, en primer lloc, situar l’autor valencià en el nou paradigma teòric de la formació escolàstica, i, en segon lloc, comprovar en quin grau els coneixement teòrics d’aquesta formació, molt presents en l’Espill, contribueixen o no a una relectura menys connotada de l’obra. In many cases, studies on the Espill of Jaume Roig focused exclusively on the misogynist aspects of the work, which has prevented further other aspects that, maybe, may alleviate this burden. That is why we propose, first, to locate the Valencian author on the new theoretical paradigm of scholastic education, and secondly, check the extent to which knowledge of the theoretical training, present in the Espill: that will contribute or not to rreading the work less connoted.

Superresolution and Fluorescence Dynamics Evidence Reveal That Intact Liposomes Do Not Cross the Human Skin Barrier.

Directory of Open Access Journals (Sweden)

Jes Dreier

Full Text Available In this study we use the combination of super resolution optical microscopy and raster image correlation spectroscopy (RICS to study the mechanism of action of liposomes as transdermal drug delivery systems in human skin. Two different compositions of liposomes were applied to newly excised human skin, a POPC liposome and a more flexible liposome containing the surfactant sodium cholate. Stimulated emission depletion microscopy (STED images of intact skin and cryo-sections of skin treated with labeled liposomes were recorded displaying an optical resolution low enough to resolve the 100 nm liposomes in the skin. The images revealed that virtually none of the liposomes remained intact beneath the skin surface. RICS two color cross correlation diffusion measurements of double labeled liposomes confirmed these observations. Our results suggest that the liposomes do not act as carriers that transport their cargo directly through the skin barrier, but mainly burst and fuse with the outer lipid layers of the stratum corneum. It was also found that the flexible liposomes showed a greater delivery of the fluorophore into the stratum corneum, indicating that they functioned as chemical permeability enhancers.

The Battle for Heavy Water Three physicists' heroic exploits

CERN Multimedia

2002-01-01

Up until the end of the 1970s you could still catch a glimpse of his massive silhouette in the corridors of CERN. Lew Kowarksi, one of the pioneers of the Laboratory, was not only a great physicist; he was also a genuine hero of World War II. In 1940, along with Frédéric Joliot and Hans von Halban, Lew Kowarski managed to get the entire world supply of heavy water away to safety from the Nazis after a fantastic escape from occupied France. At the end of the war, the three physicists played themselves in a film about their adventures entitled 'la Bataille de l'eau lourde'. This film, which has been loaned to us by the French National Film Library, will be shown at CERN for the first time next Thursday. At the beginning of the war, heavy water (D20, two atoms of deuterium and one oxygen atom) was of strategic importance. In 1939 Frédéric Joliot, aided by Hans von Halban and Lew Kowarski, demonstrated the nuclear chain reaction and the moderator role that heavy water plays in it. A few weeks before the inv...

Economia funerària a la segona edat del ferro de les illes Balears. L’ús diacrític del sacrifici de bòvids en el santuari i les necròpolis de l’àrea de Son Real (Mallorca

Directory of Open Access Journals (Sweden)

Jordi Hernández-Gasch

2011-10-01

Full Text Available L’aparició d’un objecte excepcional fet d’os de bòvid anomenat tap en emplaçaments rituals de la segona edat del ferro va permetre fa uns anys postular una hipòtesi anomenada d’”economia funerària”. Les dades procedents d’assentaments suggereixen que la cabana ramadera va canviar en la seva composició, disminuint la quantitat de bòvids en favor dels ovicàprids. El perfil de sacrifici també va canviar orientant l’ús d’aquests animals domèstics cap a l’obtenció de productes secundaris i la força de treball. Les recents troballes de la necròpolis de Son Real i del Santuari de la Punta des Patró a Mallorca apunten vers un ritual de comensalitat, on presumiblement els sectors més rics de la societat haurien consumit carn de bòvid en els rituals funeraris o l’haurien emprada com a ofrena, en contraposició als grups menys rics que només haurien tingut accés a la carn de suid o ovicàprid.

L’émergence des comédies communautaires dans le cinéma français : Ambiguïtés et paradoxes

NARCIS (Netherlands)

Rosello, M.

2017-01-01

Cet article suggère que depuis le début du vingt-et-unième siècle, un nouveau genre a fait son apparition en France : la comédie communautaire. A l’écoute des analyses politiques et esthétiques qui ont accueilli des films comme Intouchables (Éric Toledano and Oliver Nakache, 2011), Qu’est-ce qu’on a

Down-Regulation of Olfactory Receptors in Response to Traumatic Brain Injury Promotes Risk for Alzheimers Disease

Science.gov (United States)

2015-12-01

group assignment of samples in unsupervised hierarchical clustering by the Unweighted Pair-Group Method using Arithmetic averages ( UPGMA ) based on...log2 transformed MAS5.0 signal values; probe set clustering was performed by the UPGMA method using Cosine correlation as the similarity met- ric. For...differentially-regulated genes identified were subjected to unsupervised hierarchical clustering analysis using the UPGMA algorithm with cosine correlation as

Radar Cross Section (RCS) Simulation for Wind Turbines

Science.gov (United States)

2013-06-01

wind turbines are unsafe to operate. Also, helical wind turbines generally have less environmental concerns such as killing birds , especially in...SECTION (RCS) SIMULATION FOR WIND TURBINES by Cuong Ton June 2013 Thesis Advisor: David C. Jenn Second Reader: Ric Romero THIS PAGE...TITLE AND SUBTITLE RADAR CROSS SECTION (RCS) SIMULATION FOR WIND TURBINES 5. FUNDING NUMBERS 6. AUTHOR(S) Cuong Ton 7. PERFORMING ORGANIZATION

Further Results on Constructions of Generalized Bent Boolean Functions

Science.gov (United States)

2016-03-01

China; 2Naval Postgraduate School, Applied Mathematics Department, Monterey, CA 93943, USA; 3Science and Technology on Communication Security...in 1976 as an interesting combinatorial object with the important property of having op- timal nonlinearity [1]. Since bent functions have many...77–94 10 Zhao Y, Li H L. On bent functions with some symmet- ric properties. Discret Appl Math, 2006, 154: 2537– 2543

Mitochondrial tRNA import in Trypanosoma brucei is independent of thiolation and the Rieske protein

Czech Academy of Sciences Publication Activity Database

Paris, Zdeněk; RUBIO, M. A. T.; Lukeš, Julius; Alfonzo, J. D.

2009-01-01

Roč. 15, č. 7 (2009), s. 1398-1406 ISSN 1355-8382 R&D Projects: GA ČR GA204/06/1558; GA MŠk LC07032; GA MŠk 2B06129 Institutional research plan: CEZ:AV0Z60220518 Keywords : T. brucei * tRNA import * 2-thiolation * RIC * Rieske * Fe-S cluster Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 5.198, year: 2009

Dicty_cDB: Contig-U15486-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available 3 ( AY442211 ) Drosophila subobscura strain Palma-5 A+T rich reg... 34 1.6 3 ( AY442221 ) Drosophila subobs...phila subobscura strain Palma-1 A+T rich reg... 34 1.6 3 ( AY442209 ) Drosophila subobscura strain Hierro-21...h ... 34 1.6 3 ( AY442212 ) Drosophila subobscura strain Barcelona-12 A+T ric... 34 1.6 3 ( AY442210 ) Droso

Large-Scale Linear Optimization through Machine Learning: From Theory to Practical System Design and Implementation

Science.gov (United States)

2016-08-10

IEEE, 2005. Mohsen Bayati, Christian Borgs , Jennifer Chayes, and Ric- cardo Zecchina. Belief propagation for weighted b- matchings on arbitrary...on automatic protocol behavior analysis and Resource management for hyper connected for IoT Services); the Center for Integrated Smart Sensors funded...maximum weight b-matching,” in International Conference on Artificial Intelligence and Statistics, 2007, pp. 195–202. [13] M. Bayati, C. Borgs , J

Allogeneic Stem Cell Transplant for Acute Myeloid Leukemia: Evolution of an Effective Strategy in India

Directory of Open Access Journals (Sweden)

Abhijeet Ganapule

2017-12-01

Full Text Available Purpose: There are limited data from developing countries on the role and cost-effectiveness of allogeneic stem cell transplantation (allo-SCT for patients with acute myeloid leukemia (AML. Patients and Methods: We undertook a retrospective descriptive study of all patients with AML who underwent allo-SCT from 1994 to 2013 at our center to evaluate the clinical outcomes and cost-effectiveness of this therapeutic modality. Results: Two hundred fifty-four consecutive patients, median age 34 years, who underwent allo-SCT at our center were included in this study. There were 161 males (63.4%. The 5-year overall survival (OS and event-free survival for the entire cohort was 40.1 ± 3.5% and 38.7 ± 3.4%, respectively. The 5-year OS for patients in first (CR1, second, and third complete remission and with disease/refractory AML was 53.1 ± 5.2%, 48.2 ± 8.3%, 31.2 ± 17.8%, and 16.0 ± 4.4%, respectively (P < .001. From 2007, reduced intensity conditioning (RIC with fludarabine and melphalan (Flu/Mel was used in a majority of patients in CR1 (n = 67. Clinical outcomes were compared with historical conventional myeloablative conditioning regimens (n = 38. Use of Flu/Mel was associated with lower treatment-related mortality at 1 year, higher incidence of chronic graft-versus-host-disease, and comparable relapse rates. The 5-year OS and event-free survival for Flu/Mel and myeloablative conditioning group was 67.2 ± 6.6% versus 38.1 ± 8.1% (P = .003 and 63.8 ± 6.4% versus 32.3 ± 7.9% (P = .002, respectively. Preliminary cost analysis suggests that in our medical cost payment system, RIC allo-SCT in CR1 was likely the most cost-effective strategy in the management of AML. Conclusion: In a resource-constrained environment, Flu/Mel RIC allo-SCT for AML CR1 is likely the most efficacious and cost-effective approach in a subset of newly diagnosed young adult patients.

Presencia del Paijanense en el desierto de Ica

Directory of Open Access Journals (Sweden)

1990-01-01

Full Text Available PRESENCE DU PAIJANIEN DANS LE DESERT DE ICA. Dans plusieurs publications, Frédéric Engel donne des informations qui suggèrent la présence de Paijanien dans la zone de la péninsule de Paracas. Après une minutieuse analyse des publications, des collections d’Engel et après des prospections de terrain menées en dépit des imprécisions existantes dans ses écrits, les auteurs ont pu trouver des évidences de restes qui du point de vue technologique, correspondent au Paijanien. Ils décrivent donc leurs trouvailles et analysent de manière critique les matériaux des collections d’Engel. En algunas publicaciones Frédéric Engel da informaciones que sugieren la presencia de la cultura Paijanense en el área de la Península de Paracas. A pesar de las imprecisiones existentes en los escritos de este autor, después de un prolijo análisis documental de las colecciones hechas por éste, además de trabajos de campo, los autores han podido encontrar las evidencias de restos que, tecnológicamente, corresponden a la industria Paijanense. Se describe el hallazgo y, al mismo tiempo, se discute críticamente los materiales existentes en las colecciones de Engel. PAIJÁN PRESENCE IN THE DESERT OF ICA. Several publications of Frédéric Engel have presented information that suggests the presence of the Paiján culture in the Paracas peninsula area. In spite of the inherent lack of precision in Engel’s writings, after an extensive review of the documentation and collections made by Engel and their survey of the area, the authors found evidence of remains that technologically correspond to the Paiján culture. They describe their finds and critically examine the materials in Engel’s collections.

[Reduced intensity conditioning allogeneic hematopoietic stem cell transplantation in chronic lymphocytic leukemia (CLL) patients with the aberration of p53 gene].

Science.gov (United States)

Wang, Li; Miao, Kourong; Fan, Lei; Xu, Ji; Wu, Hanxin; Li, Jianyong; Xu, Wei

2016-04-01

To investigate the effectiveness and safety of reduced intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC allo-HSCT) in ultra high risk chronic lymphocytic leukemia (CLL) patients with the deletion of p53 to deepen the understanding of allo-HSCT in the treatment of CLL. In this retrospective study, a total of 4 ultra high risk CLL patients with the deletion of p53 in our center between July 2012 and Jan 2014 were enrolled. The RIC regimen was administered and the hematopoietic reconstitution, transplantation related mortality (TRM), overall survival (OS), progress free survival (PFS) were evaluated. We registered 4 patients with the median age of 56 years (49-61 years), including 3 males and 1 female. The median mononuclear cells (MNC) and CD34(+) cells were 6.54 (2.85-14.7) × 10(8)/kg (recipient body weight) and 5.81 (2.85-7.79) × 10(6)/kg (recipient body weight), respectively. The median time of the neutrophil recovery was 11 days (range of 9-12 days), and the median time of the platelet recovery 5.5 days (range of 0-11 days). Three patients (75%) attained a full donor chimerism at day 28 after transplantation and one (25%) got a mixed chimerism of donor and recipient. During the follow-up at a median time of 26.5 months (range of 21-39 months), 2 (50%) patients developed acute graft versus host disease (aGVHD) grade I and 2 (50%) patients got CMV infection. One patient got herpes zoster virus and EB virus infections. No transplantation related mortality was found in the 4 patients. One patient who was in partial response status progressed 5 months after transplantation, and the other 3 patients remained in durable remission after allo-HSCT. These results suggested that RIC allo-HSCT showed durable remission, good tolerance and acceptable toxicity, which could be a better option for the treatment of ultra high risk CLL patients with the deletion of p53 and was worth to be investigated and applied widely in future.

Narrative Refiguration of Social Events: Paul Ricoeur's Contribution to Rethinking the Social

Directory of Open Access Journals (Sweden)

Anna Borisenkova

2010-12-01

Full Text Available The analysis of events has been a central issue for social sciences for a long time. The problem of an event's definition and distinction is still at stake in sociological debates. The purpose of this paper is to demonstrate the contribution of Paul Ricoeur's narrative theory to social events studies. First, this is done through the explication of the concept in the framework of narrative approach. Secondly, the paper highlights the narrative's capacity of 'refiguring' the social by re-describing social events, subordinating their succession to the logic of story-telling and transforming temporal characteristics as well. Apart from some insights, interpretative explanations and illustrations the paper provides critical arguments concerning the limitations of Paul Ricoeur's narrative approach with respect to sociological event-analysis.     L'analyse des événements a toujours été une question centrale pour l'histoire et les sciences sociales. Le problème de la définition et de la distinction des événements est encore en jeu dans les débats sociologiques contemporains. L'objectif de cet article est de s'attarder sur la contribution de la théorie de Paul Ricœur aux études des événements sociaux.  Après avoir montré les limites d'une conception impersonnelle de l'événement, l'auteur se penche sur la solution narrative proposée par Ricœur, à savoir la capacité du récit à “refigurer” du Social par la re-description des événements sociaux. Il s'agit de soumettre la logique de la succession temporelle à la logique de la narration. Tout en rendant justice à la valeur heuristique de telles analyses (à travers une série d'explicitations et d'illustrations, l'article pointe les limites de l'approche narrative de Paul Ricœur au regard des analyses sociologique des événements.  

Environmental Assessment, Glide Slope/Clear Zone Obstructions, Wright-Patterson Air Force Base, Ohio

Science.gov (United States)

2013-06-01

the Integrated Cultural Resources Managemen t Plan. Historic resou rces determined to be eligible fo r listing on the National Register of Histo ric... Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other...and clear zones (CZs) at WPAr B in order to protect human hea lth and safety by providing adequate clearance for aircraft operations . The existing

The classification of chronic daily headache in French children and adolescents: A comparison between the second edition of the International Classification of Headache Disorders and Silberstein-Lipton criteria

OpenAIRE

Jean-Christophe Cuvellier; Frédéric Couttenier; Stéphane Auvin; Louis Vallée

2008-01-01

Jean-Christophe Cuvellier1, Frédéric Couttenier2, Stéphane Auvin1, Louis Vallée11Department of Child Neurology, Pediatric Clinic, University Hospital, Lille, France; 2Division of Gastroenterology, Hepatology and Nutrition, Pediatric Clinic, University Hospital, Lille, FranceAbstract: Few data are available on the applicability of both the criteria proposed by Silberstein and Lipton (S-L) and the International Classification of Headache Disorders-II ...

Den uendelige parrhesi

DEFF Research Database (Denmark)

Pallesen, Carsten

2015-01-01

The article examines the role of narrative discourse in religious education and communication as represented in Kirsten Andersen’s Kantian approach. In Hegel’s Lutheran perspective figurative thinking is deconstructed in forms of interpretive narrative, the topos of the speculative Good Friday...... to the Kantian account is inspired by Paul Ricœur, Günter Bader, Niklas Luhmann, Jacques Derrida, Catherine Malabou and Vladimir Jankélévitch....

Deep Learning Online Course

Science.gov (United States)

2016-11-01

slides and videos2, detailed course notes were made available online. There were also three homework assignments with starter Python code aimed at...Integration Center (CAMEO/RIC) project. In May, Don Waagen from the Army’s Aviation and Missile Research , Development, and Engineering Center (AMRDEC) shared...Vu Tran, a researcher with Booz Allen Hamilton, presented his work on applications of convolutional neural networks for image and video. There was

The Clyde Estuary and Firth. An Assessment of Present Knowledge.

Science.gov (United States)

1974-05-01

ornithological subjects. Ailsa Craig , the last decade, the Clyde catch in 1970 being worth and Horse Island, off Ardrossan, are notedfor bird life. A...gannet (Sula bassana) coming in to land on Ailsa Craig (photo by courtesy of Niall Rank/n/E ric Hosking) . / - “ - - 7 - (2’ 5...I’ GEOLOGICAL INVESTIGATIONS IN THE FIRTH OF CLYDE MADE BY THE INSTITUTE OF GEOLOGICAL SCIENCES C E Deegan , IGS Continental Shelf Unit

Various Effects of Embedded Intrapulse Communications on Pulsed Radar

Science.gov (United States)

2017-06-01

the degree of MASTER OF SCIENCE IN ELECTRICAL ENGINEERING from the NAVAL POSTGRADUATE SCHOOL June 2017 Approved by: Ric A. Romero Thesis Co-Advisor...the shape of the radar signal in the frequency domain, differing only in magnitude. The PSDs for the communications signal alone at various RCR levels ...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS VARIOUS EFFECTS OF EMBEDDED INTRAPULSE COMMUNICATIONS ON PULSED RADAR by Allison Hunt June 2017

No improvement of survival with reduced- versus high-intensity conditioning for allogeneic stem cell transplants in Ewing tumor patients

OpenAIRE

Thiel, U.; Wawer, A.; Wolf, P.; Badoglio, M.; Santucci, A.; Klingebiel, T.; Basu, O.; Borkhardt, A.; Laws, H.-J; Kodera, Y.; Yoshimi, A.; Peters, C.; Ladenstein, R.; Pession, A.; Prete, A.

2017-01-01

Background: Outcomes of Ewing tumor (ET) patients treated with allogeneic stem cell transplantation (allo-SCT) were compared regarding the use of reduced-intensity conditioning (RIC) and high-intensity conditioning (HIC) regimens as well as human leukocyte antigen (HLA)-matched and HLA-mismatched grafts. Patients and methods: We retrospectively analyzed data of 87 ET patients from the European Group for Blood and Marrow Transplantation, Pediatric Registry for Stem Cell Transplantations, Asia ...

Cognition in the Brain: Investigations Using Positron Emission Tomography

Science.gov (United States)

1992-07-16

0029 DDIRESS (City. State and ZIP Code) 10. SOURCE Of FUNDING NOS. _____________ .dg. 410 PROGRAM PROJECT TASKC WORK .,%r illing Air Force Base, DC...Bethesda, MD 20892 20. Daniel Bubb, M.D. Department of Neurolinguistics Montreal Neurological Institute 15. Sung-cheng tHuang, Ph.D. 3801 University...Chief of Pediatric Neu- rology Service Director, Center for Morphomet- 24. Terry Allard, Ph.D. ric Analysis Cognitive Science Programs Kennedy 9 Office

ALLOGENEIC TRANSPLANTATION FOR CHRONIC LYMPHOCYTIC LEUKEMIA

Directory of Open Access Journals (Sweden)

Luca Laurenti

2010-08-01

Full Text Available Even if Chronic lymphocytic leukemia (CLL often has an indolent behavior with good responsiveness to cytoreductive treatment, about 20% of the patients, so called "poor-risk" patients, show an aggressive course and die within a few years despite early intensive therapies. Criteria for poor-risk disease according to the European Bone Marrow Transplantation (EBMT CLL Transplant Consensus are: purine analogue refractoriness, early relapse after purine analogue combination therapy, CLL with p53 lesion requiring treatment. Allogeneic transplant has potential curative role in CLL, however burden with very  high transplant related mortality (TRM rates of 38-50%: A major advance in reducing the short-term morbidity and mortality of allogeneic stem cell transplantation (SCT has been the introduction of non-myeloablative or reduced intensity conditioning (RIC regimens to allow engraftment of allogeneic stem cells. There is no doubt that the crucial therapeutic principle of allo-SCT in CLL is graft versus leukemia (GVL activity. The major complications of allogeneic SCT in CLL are: chronic graft-versus-host-disease (GVHD affecting quality of life, high graft rejection and infection rates rates correlated with preexisting immunosuppression. Disease relapse remains the major cause of failure after RIC allo-HCT in CLL patients. Sensitive minimal residual disease (MRD quantification has strong prognostic impact after transplant.

Gregorio Marañón y Miguel de Unamuno, lectores de un alma abrasada en un diario. Apuntes para una psicología de la timidez

Directory of Open Access Journals (Sweden)

José María Ariso

2014-06-01

Full Text Available After describing the main lines of the interpretations of Henri-Frédéric Amiel’s diary held by Gregorio Marañón and Miguel de Unamuno, Otto Weininger’s work is brought up in this paper in order to consider both interpretations from a wider perspective that helps to discern which were Marañón’s and Unamuno’s interests when they analyzed Amiel’s life and personality

Bologna auf dem Markt der Meinungsmöglichkeiten : was mit den Studierendenprotesten gesagt werden sollte - und was verstanden wurde

OpenAIRE

Kunze, Manuel; Tielesch, Simon

2010-01-01

"Das Schlagwort 'Bologna' ist ein zunehmend sinnentleerter Sammelbegriff für die Reform der europäischen Universitäten; der Bildungsstreik vom Sommer und Herbst 2009 geriet zum Schlachtfeld um die Meinungshoheit im Bildungsdiskurs. An den vier Beispielen der Studiengebühren, der studentische Mitbestimmung, des gezielten Missverstehens und der Ökonomisierung der Hochschulen wird gezeigt, wie die Studierendenproteste vom Herbst 2009 von denjenigen genutzt wurden, gegen die sich die Proteste ric...

Defense Standardization Program Journal. November 2002/February 2003

Science.gov (United States)

2003-02-01

8217 website, the nonprofit USMA has The National Council of Teachers many types of metric supplies and I I of Mathematics ( NCTM ), in recogni- training...aids available for sale. Also . ,. tion of the metrication efforts of available is a CD) that contains a Met- mathematics teachers , started National...ric Bibliography database of more thanE Metric Week in 1976. In those early 14,000 references to articles about the years, NCTM celebrated National

Conserver la biodiversité intra-spécifique des arbres forestiers en France et en Europe

Directory of Open Access Journals (Sweden)

COLLIN, Éric

2010-10-01

Full Text Available À l'aide d'exemples issus de son expertise en matière d'ormes et de son expérience de Secrétaire de la commission «Ressources génétiques forestières», Éric Collin illustre les enjeux et méthodes de la conservation de la diversité génétique des arbres forestiers dans la perspective du changement climatique.

Analyzing the Cooking Behavior of Sophomore Female Students : In relation to the ability for preparation of cooking

OpenAIRE

Imakawa, Shinji

2012-01-01

The aim of this study was to clarify the Dandori-ryoku (the ability for preparation in cooking) by analyzing the practical cooking behavior of sophomore female students. Ten sophomore female students were participated in the experiment to cook three kinds of food (cooking rice, making miso soup and fried vegetables). The behavior of the participants during cooking were videotaped and analyzed in detail later especially in relation to Dandori-ryoku. Such behaviors as “starting from cooking ric...

Defense Transportation Regulation. Part I: Passenger Movement

Science.gov (United States)

1998-03-01

indicates apart action and the "N" in the special handling block identifies the passenger as a no-show. NAME RIC CHANL MSN- NBR /TVL-PD STS...will be retained and annotated with the origin, destination, ticket or token number(s) (when issued), and date issued to traveler. A rubber stamp...J. D. Pierce, TO. The use of a rubber stamp signature of the person authorized to sign GTRs is strictly prohibited. b. Other person(s) (acting TOs

Statistical Methods for Studying Genetic Variation in Populations

Science.gov (United States)

2012-08-01

iteration will converge to a local optimum, similar to what happens in an EM algorithm. Empirically, a near global optimal can be obtained by multiple...and E Matthysen. Genetic variability and gene flow 131 in the globally , critically-endangered Taita thrush. Conservation Genetics, 1:45–55, 2000. 4.5.2...Libioulle, Edouard Louis, Sarah Hansoul, Cynthia Sandor, Frédéric Farnir, Denis Franchi - mont, Séverine Vermeire, Olivier Dewit, Martine de Vos, Anna

Self-Assembly of Large-Scale Shape-Controlled DNA Nano-Structures

Science.gov (United States)

2014-12-16

for single-molecule imaging. Nano Lett. 11, 657-660 (2011). 46. Dang, X. N. et at. Virus -templated self-assembled single-walled carbon nanotubes for...email: alik(a)rics.bwh.harvard edu). NATURE C0,M.MUN! CAT !0N5 14:2275 I DOI: 10.1038/ncomm53275 | wwwnature.com/naturecommunications 1 @ 2013 Macmillan...prevent non-specific binding between hydrogel and microtube, the inside surface of microtube was treated with a corona treater (BD-20AC from Electro

Uso de sustancias antimicrobianas naturales en combinación con compuestos estabilizadores de la calidad para controlar microorganismos patógenos y extender la vida útil de las frutas frescas cortadas

OpenAIRE

Raybaudi Massilia, Rosa M.

2007-01-01

El consum de fruites fresques tallades i sucs de fruites no pasteuritzats s'haincrementat significativament en els darrers anys degut a la creixent demanda deproductes sans de baix contingut calòric i característiques similars a les del productefresc. Tot i això, aquests productes poden contaminar-se amb microorganismespatògens o deterioratius per una inadequada manipulació o emmagatzematge, donantlloc a riscs de malalties microbianes i deteriorament del producte. De fet, el nombrede brots i ...

Telework and daily life: Its pros and cons for work-life balance

OpenAIRE

Carmen Pérez Sánchez; Ana María Gálvez Mozo

2009-01-01

In this article we discuss whether telework constitutes a useful work-life balance strategy for women teleworkers with dependants. From our analysis we show that the discourse of the women interviewed about telework is not homogeneous, compact or linear, but includes plenty of contradictions, paradoxes and tensions. This fact reinforces telework’s enormous polysemy: it liberates and enslaves, it is a trap and an opportunity, it fulfills and can mean self-sacrifice. But, despite this ric...

TESTING METHODS FOR MECHANICALLY IMPROVED SOILS: RELIABILITY AND VALIDITY

Directory of Open Access Journals (Sweden)

Ana Petkovšek

2017-10-01

Full Text Available A possibility of in-situ mechanical improvement for reducing the liquefaction potential of silty sands was investigated by using three different techniques: Vibratory Roller Compaction, Rapid Impact Compaction (RIC and Soil Mixing. Material properties at all test sites were investigated before and after improvement with the laboratory and the in situ tests (CPT, SDMT, DPSH B, static and dynamic load plate test, geohydraulic tests. Correlation between the results obtained by different test methods gave inconclusive answers.

A Password System Based on Sketches

Science.gov (United States)

2016-07-12

Cognometric—recognition-based methods (also referred to as search met- ric [10]) 3 3. Locimetric— cued - recall based methods. Drawmetric systems require users to...chosen, hence the term cued - recall . The most prominent cued - recall based method is PassPoints [6, 7, 8]. Pass- Points presents the user with a single...around for more than a decade. Graphical passwords belong to one of three groups (as proposed in [9]): 1. Drawmetric— recall -based methods60 2

Renyi generalizations of the conditional quantum mutual information

Science.gov (United States)

2015-02-23

Physical Review Letters, 100(23):230501, June 2008. [20] Frederic Dupuis , Lea Kramer, Philippe Faist, Joseph M. Renes, and Renato Renner. Pro- ceedings...relative Rényi entropy. Journal of Mathematical Physics, 54(12):122201, December 2013. arXiv:1306.5358. 49 [25] Christopher A. Fuchs and Jeroen van de...Lennert, Frédéric Dupuis , Oleg Szehr, Serge Fehr, and Marco Tomamichel. On quantum Rényi entropies: a new definition and some properties. Journal

Transcutaneous spinal direct current stimulation of the lumbar and sacral spinal cord: a modelling study

Science.gov (United States)

Fernandes, Sofia R.; Salvador, Ricardo; Wenger, Cornelia; de Carvalho, Mamede; Miranda, Pedro C.

2018-06-01

Objective. Our aim was to perform a computational study of the electric field (E-field) generated by transcutaneous spinal direct current stimulation (tsDCS) applied over the thoracic, lumbar and sacral spinal cord, in order to assess possible neuromodulatory effects on spinal cord circuitry related with lower limb functions. Approach. A realistic volume conductor model of the human body consisting of 14 tissues was obtained from available databases. Rubber pad electrodes with a metallic connector and a conductive gel layer were modelled. The finite element (FE) method was used to calculate the E-field when a current of 2.5 mA was passed between two electrodes. The main characteristics of the E-field distributions in the spinal grey matter (spinal-GM) and spinal white matter (spinal-WM) were compared for seven montages, with the anode placed either over T10, T8 or L2 spinous processes (s.p.), and the cathode placed over right deltoid (rD), umbilicus (U) and right iliac crest (rIC) areas or T8 s.p. Anisotropic conductivity of spinal-WM and of a group of dorsal muscles near the vertebral column was considered. Main results. The average E-field magnitude was predicted to be above 0.15 V m-1 in spinal cord regions located between the electrodes. L2-T8 and T8-rIC montages resulted in the highest E-field magnitudes in lumbar and sacral spinal segments (>0.30 V m-1). E-field longitudinal component is 3 to 6 times higher than the ventral-dorsal and right-left components in both the spinal-GM and WM. Anatomical features such as CSF narrowing due to vertebrae bony edges or disks intrusions in the spinal canal correlate with local maxima positions. Significance. Computational modelling studies can provide detailed information regarding the electric field in the spinal cord during tsDCS. They are important to guide the design of clinical tsDCS protocols that optimize stimulation of application-specific spinal targets.

The never-ending digital journey creating new consumer experiences through technology

CERN Document Server

Angelani, Andres; Migoya, Martin

2016-01-01

The Never-Ending Digital Journey provides readers with the concepts and steps needed to create successful user experiences. The authors look ahead and explore digital scenarios of the future. They probe how technology is changing the way users interact with brands, and they address today's digital challenges with new ways of surprising consumers, integrating design and engineering. The authors leverage knowledge gleaned from working with renowned global companies to describe the recipe needed to build a Digital Journey. With a strong focus on Agile Pods, they dive into technolo- gies, processes, team building, motivation, and met- rics that enable businesses to construct and nurture the dynamic ecosystems necessary in this digital era to foster success. Over the last several years, customers, employees, and partners have become tech-savvy users whose expectations of “Give me more and deliver it faster" require manageable solutions. The desire to interact with digital ecosystems anywhere, anytime demands that...

The reactor core configuration and important systems related to physics tests of Daya Bay NPP

International Nuclear Information System (INIS)

Tao Shaoping

1995-06-01

A brief introduction to reactor core configuration and important systems related to physics tests of Daya Bay NPP is given. These systems involve the reactor core system (COR), the full length rod control system (RGL), the in-core instrumentation system (RIC), the out-of-core nuclear instrumentation system (RPN), and the LOCA surveillance system (LSS), the centralized data processing system (KIT) and the test data acquisition system (KDO). In addition, that the adjustment and evaluation of boron concentration related to other systems, for example the reactor coolant system (RCP), the chemical and volume control system (RCV), the reactor boron and water makeup system (REA), the nuclear sampling system (REN) and the reactor control system (RRC), etc. is also described. Analysis of these systems helps not only to familiarize their functions and acquires a deepen understanding for the principle procedure, points for attention and technical key of the core physics tests, but also to further analyze the test results. (3 refs., 11 figs., 1 tab.)

A physico-genetic module for the polarisation of auxin efflux carriers PIN-FORMED (PIN)

Science.gov (United States)

Hernández-Hernández, Valeria; Barrio, Rafael A.; Benítez, Mariana; Nakayama, Naomi; Romero-Arias, José Roberto; Villarreal, Carlos

2018-05-01

Intracellular polarisation of auxin efflux carriers is crucial for understanding how auxin gradients form in plants. The polarisation dynamics of auxin efflux carriers PIN-FORMED (PIN) depends on both biomechanical forces as well as chemical, molecular and genetic factors. Biomechanical forces have shown to affect the localisation of PIN transporters to the plasma membrane. We propose a physico-genetic module of PIN polarisation that integrates biomechanical, molecular, and cellular processes as well as their non-linear interactions. The module was implemented as a discrete Boolean model and then approximated to a continuous dynamic system, in order to explore the relative contribution of the factors mediating PIN polarisation at the scale of single cell. Our models recovered qualitative behaviours that have been experimentally observed and enable us to predict that, in the context of PIN polarisation, the effects of the mechanical forces can predominate over the activity of molecular factors such as the GTPase ROP6 and the ROP-INTERACTIVE CRIB MOTIF-CONTAINING PROTEIN RIC1.

Peripheral blood hematopoietic stem cells for transplantation of hematological diseases from related, haploidentical donors after reduced-intensity conditioning.

Science.gov (United States)

Raj, Kavita; Pagliuca, Antonio; Bradstock, Kenneth; Noriega, Victor; Potter, Victoria; Streetly, Matthew; McLornan, Donal; Kazmi, Majid; Marsh, Judith; Kwan, John; Huang, Gillian; Getzendaner, Lisa; Lee, Stephanie; Guthrie, Katherine A; Mufti, Ghulam J; O'Donnell, Paul

2014-06-01

In a multicenter collaboration, we carried out T cell-replete, peripheral blood stem cell (PBSC) transplantations from related, HLA-haploidentical donors with reduced-intensity conditioning (RIC) and post-transplantation cyclophosphamide (Cy) as graft-versus-host disease (GVHD) prophylaxis in 55 patients with high-risk hematologic disorders. Patients received 2 doses of Cy 50 mg/kg i.v. on days 3 and 4 after infusion of PBSC (mean, 6.4 × 10(6)/kg CD34(+) cells; mean, 2.0 × 10(8)/kg CD3(+) cells). The median times to neutrophil (500/μL) and platelet (>20,000/μL) recovery were 17 and 21 days respectively. All but 2 of the patients achieved full engraftment. The 1-year cumulative incidences of grade II and grade III acute GVHD were 53% and 8%, respectively. There were no cases of grade IV GVHD. The 2-year cumulative incidence of chronic GHVD was 18%. With a median follow-up of 509 days, overall survival and event-free survival at 2 years were 48% and 51%, respectively. The 2-year cumulative incidences of nonrelapse mortality and relapse were 23% and 28%, respectively. Our results suggest that PBSC can be substituted safely and effectively for bone marrow as the graft source for haploidentical transplantation after RIC. Copyright © 2014 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Una experiencia de la sin razón/An experience on the unreason

Directory of Open Access Journals (Sweden)

Mauro Marchese

2010-03-01

Full Text Available En este trabajo pongo en consideración si corresponde o no afirmar que el psicoanálisis nació como empresa de medicalización del cuerpo sexual y por ello participa de una filiación disciplinaria. Para esto tomo en cuenta algunas reflexiones de Frédéric Gros acerca del concepto de sexualidad en la obra de Foucault, ciertos pasajes de Historia de la locura en la época clásica, El poder psiquiátrico y Entre filosofía y literatura, para confrontarlos con otras consideraciones que hiciera J. Derrida sobre el lugar y el rol del psicoanálisis en el proyecto foucaultiano de una historia de la locura. In this work I consider the question whether corresponds to affirm that Psychoanalysis was born as an enterprise with the purpose of medicalising the sexual body, and thus it is part of a discipline. For this analysis I take into account some of the thoughts by Frédéric Gros about the concept of sexuality in the work of Foucault, some fragments of History of Madness, Psychiatric Power and Dits et écrits, to confront them with other considerations by J. Derrida about the place and role of the Psychoanalysis on Foucault´s project for a history of madness.

In vitro and preclinical targeted alpha therapy for cancer

International Nuclear Information System (INIS)

Allen, B.J.; Rizvi, S.; Li, Y.; Tian, Z.; University of Wollongong, NSW; Ranson, M.; Russell, P.J.

2000-01-01

Full text: Targeted Alpha therapy (TAT) offers the potential to inhibit the growth of micrometastases by selectively killing isolated and preangiogenic clusters of cancer cells. The alpha emitting radioisotope Bi-213 is produced by generator and chelated to a cancer affined monoclonal antibody or protein to form the alpha-conjugate (AC) against melanoma, leukaemia, colorectal, bladder, breast and prostate cancers. These ACs are tested for stability, specificity and cytotoxicity. Subcutaneous inoculation of 1.5 million cells into the flanks of nude mice causes tumours to grow in all mice. The tumour growth is compared between untreated controls, nonspecific RIC and specific RIC, for local (subcutaneous) and systemic (tail vein or intraperitoneal) injection models. Results: Stable alpha-ACs can be produced which are highly specific and cytotoxic in vitro. Local TAT at 2 days post-inoculation completely prevents tumour formation for all cancers tested so far. Local TAT can also completely regress (11/12) sc melanoma but is less successful for breast and prostate cancers. Systemic TAT inhibits the growth of sc melanoma xenografts. These results point to the potential application of local TAT and systemic TAT in the management of these cancers. A phase 1 and 2 clinical trial is planned for local TAT of sc recurrent melanoma. Copyright (2000) Australasian College of Physical Scientists and Engineers in Medicine

177Lu-DOTA-HH1, a novel anti-CD37 radio-immunoconjugate: a study of toxicity in nude mice.

Directory of Open Access Journals (Sweden)

Ada H V Repetto-Llamazares

Full Text Available CD37 is an internalizing B-cell antigen expressed on Non-Hodgkin lymphoma (NHL and chronic lymphocytic leukemia cells (CLL. The anti-CD37 monoclonal antibody HH1 was conjugated to the bifunctional chelator p-SCN-Bn-DOTA and labelled with the beta-particle emitting radionuclide 177Lu creating the radio-immunoconjugate (RIC 177Lu-DOTA-HH1 (177Lu-HH1, trade name Betalutin. The present toxicity study was performed prior to initiation of clinical studies with 177Lu-HH1.Nude mice with or without tumor xenografts were treated with 50 to 1000 MBq/kg 177Lu- HH1 and followed for clinical signs of toxicity up to ten months. Acute, life threatening bone marrow toxicity was observed in animals receiving 800 and 1000 MBq/kg 177Lu-HH1. Significant changes in serum concentrations of liver enzymes were evident for treatment with 1000 MBq/kg 177Lu-HH1. Lymphoid depletion, liver necrosis and atrophy, and interstitial cell hyperplasia of the ovaries were also observed for mice in this dose group.177Lu-DOTA-HH1 was well tolerated at dosages about 10 times above those considered relevant for radioimmunotherapy in patients with B-cell derived malignancies.The toxicity profile was as expected for RICs. Our experimental results have paved the way for clinical evaluation of 177Lu-HH1 in NHL patients.

Material d'estudi de psicofarmacologia

OpenAIRE

Moya Albiol, Luis

2012-01-01

Material d'estudi de psicofarmacologia: Delimitació conceptual i desenvolupament històric de la psicofarmacologia. Neurobiologia dels trastorns mentals. Conceptes bàsics en psicofarmacologia. Metodologia i tècniques d’investigació en psicofarmacologia. Bases biològiques dels trastorns de l’estat d’ànim. Antidepressius i estabilitzadors de l’estat d’ànim. Bases biològiques de l’ansietat. Ansiolítics i hipnòtics. Tractaments farmacològics per el trastorn obsessivo-compu...

Fiction e identità narrativa

Directory of Open Access Journals (Sweden)

Roberto Talamo

2012-06-01

Full Text Available Nell’articolo si compie una ricognizione dei principali indirizzi di teoria del romanzo che leggono questo genere narrativo come forma della vita interiore svelata. Confrontando queste teorie con il concetto di “identità narrativa” sviluppato da Ricœur, si propone un’idea originale di analisi delle vite interiori narrate nella fiction, a partire dalla definizione auerbachiana di “realismo moderno” come tentativo di avvicinarsi alla realtà oggettiva tramite “molte impressioni soggettive avute da molte persone”.

LA BANDE DES QUATRE: Nineteenth-century Artistic and Literary Sources in Late Nouvelle Vague Filmmaking

OpenAIRE

Tavassoli Zea, Zahra

2016-01-01

This thesis examines the different ways the cinemas of Éric Rohmer, Jacques Rivette, François Truffaut and Jean-Luc Godard adapted literary and artistic motifs characteristic of the nineteenth-century romantic and realist traditions, from the 1960s to the 1980s. The selection of these four directors is based on their early and formative commitment to the politique des auteurs, a film criticism trend that was significantly indebted to central aesthetic precepts of the realist and naturalist no...

Brazil and the Vital South Atlantic

Science.gov (United States)

1988-09-01

Brasileiro, Conferencia Mundial de Energia . Recursos Fnergeticos do Brasil . Rio de Janeiro, Brazil. Maio, 1970. Carvalho Filho, Milton X. As Con ferencios...Geopolhti~os en ef At,,1,nrco Sur (No other references ) Baker, P. Warren. "Next: A Resource War?" Soýa Powver, p 55, October 1980. Banco do Brasil ...Brazil, The Nevv Power Brasil . (No date Barbola, Luiz. "Itamnaraty may faz objecat." Jornal de BrasO Ric) de’ Janeiro, Bircizil. (No other ref-rence

Database Description - RMOS | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available base Description General information of database Database name RMOS Alternative nam...arch Unit Shoshi Kikuchi E-mail : Database classification Plant databases - Rice Microarray Data and other Gene Expression Database...s Organism Taxonomy Name: Oryza sativa Taxonomy ID: 4530 Database description The Ric...19&lang=en Whole data download - Referenced database Rice Expression Database (RED) Rice full-length cDNA Database... (KOME) Rice Genome Integrated Map Database (INE) Rice Mutant Panel Database (Tos17) Rice Genome Annotation Database

Estresores laborales y calidad de vida en pilotos hispanoparlantes de aeronaves comerciales

OpenAIRE

Aguirre Mas, Carla

2014-01-01

[ES]La presente investigación tiene como objetivo determinar cuales son los estresores laborales a los cuales están sometidos los profesionales pilotos de avión de aeronaves comerciales hispanoparlantes asociados a IFALPA, en aras de generar un modelo etimológico que permita diagnosticar e intervenir positivamente dichos indicadores, para ello se construyó y validó estadísticamente mediante análisis factorial confirmatorio, una escala de estresores laborales que consta de 4 dimensiones teóric...

What Determines Firms’ Decisions to Formalize?

OpenAIRE

Neil McCulloch; Günther G. Schulze; Janina Voss

2010-01-01

In this paper we analyze the decision of small and micro firms to formalize, i.e. to obtain business and other licenses in rural Indonesia. We use the rural investment climate survey (RICS) that consists of non-farm rural enterprises, most of them microenterprises, and analyze the effect of formalization on tax payments, corruption, access to credit and revenue, taking into account the endogeneity of the formalization decision to such benefits and costs. We show, contrary to most of the liter...

What determines firms' decisions to formalize? Evidence from rural Indonesia

OpenAIRE

McCulloch, Neil; Schulze, Günther G.; Voss, Janina

2010-01-01

In this paper we analyze the decision of small and micro firms to formalize, i.e. to obtain business and other licenses in rural Indonesia. We use the rural investment climate survey (RICS) that consists of non-farm rural enterprises, most of them microenterprises, and analyze the effect of formalization on tax payments, corruption, access to credit and revenue, taking into account the endogeneity of the formalization decision to such benefits and costs. We show, contrary to most of the liter...

Nitrous oxide metabolism in nitrate-reducing bacteria: Physiology and regulatory mechanisms

OpenAIRE

Torres, Maria; Simon, Jorg; Rowley, Gary; Bedmar, Eulogio; Richardson, David; Gates, Andrew; Delgado, Maria

2016-01-01

Nitrous oxide (N2O) is an important greenhouse gas (GHG) with substantial global warming potential and also contributes to ozone depletion through photochemical nit- ric oxide (NO) production in the stratosphere. The negative effects of N2O on climate and stratospheric ozone make N2O mitigation an international challenge. More than 60% of global N2O emissions are emitted from agricultural soils mainly due to the appli- cation of synthetic nitrogen-containing fertilizers. Thus, mitigation stra...

Numerical analysis of the transient radiation-induced conductivity in the framework of the Rose-Fowler-Vaisberg formalism

International Nuclear Information System (INIS)

Mingaleev, G.S.; Tyutnev, A.P.; Gerasimov, B.P.; Kulchitskaya, I.A.

1986-01-01

Computer simulation of the temperature, dose, and trap filling effects of transient RIC is carried out by means of the Rose-Fowler-Vaisberg formalism. These combined effects allow to determine the trap distribution type exponential or Gaussian, an available data favouring the former. It is also shown that the usual Rose-Fowler-Vaisberg theory modified to involve the radiation produced traps provides the basis for a consistent and quantitative understanding of dose effects encountered in repeated irradiations of polymers. (author)

Sector 7-8 powered up

CERN Document Server

2007-01-01

1. Frédéric Gicquel from the Cryogenics for Accelerators Group (AT/ACR) and Anupama Kulkarni from the Magnets and Electrical Systems Group (AT/MEL) at the CERN Control Centre during the powering-up of Sector 7-8. 2. Frédérick Bordry, leader of the Power Converter Group (AB/PO), and Roberto Saban, responsible for coordinating the LHC commissioning (TS/HDO), celebrate the end of the first powering-up of an entire LHC sector: Sector 7-8.

Incidência temporal dos gols na Copa Libertadores da Améric

Directory of Open Access Journals (Sweden)

Filipe Gomide Carelli

2017-01-01

Full Text Available Resumo Introdução: O Futebol é uma modalidade complexa e muitos fatores podem levar ao gol. Pesquisas acerca do gol mostram existir momentos críticos dentro da partida, onde os gols acontecem com maior frequência. Objetivo: Analisar a incidência temporal dos gols na Libertadores 2014. Materiais e Métodos: O estudo é descritivo. Analisou-se 126 jogos das 32 equipes participantes. A coleta dos dados foi realizada diretamente do site da CONMBOL. Cada gol foi classificado de acordo com sua incidência em um dos seis períodos: 0-15 minutos; 16-30 minutos; 31-45 minutos (incluindo os acréscimos; 46-60 minutos; 61-75 minutos e 76-90 (incluindo os acréscimos. Resultados: Foram marcados 324 gols em 126 jogos, obtendo uma média de 2,5 gols por jogo. Os gols foram realizados em sua maioria no segundo tempo das partidas com destaque para os últimos quinze minutos do jogo onde aconteceu 25,31% (n=82 dos gols. Discussão: Marques Junior (2015, em seu trabalho de revisão acerca das evidências sobre o gol no Futebol, encontrou que 55% dos gols acontecem no segundo tempo. Na Copa Libertadores da América de 2014, 25,31% dos gols aconteceram nos últimos 15 minutos. Essa evidência vai de encontro com os resultados da literatura. Fatores táticos, técnicos, físicos, nutricionais e psicológicos podem estar levando a estes resultados. Conclusão: A maioria dos gols ocorreram na segunda etapa da partida com enfâse nos ultimos quinze minutos do jogo. ABSTRACT Incidence of the goals in the Copa Libertadores of America Introduction: Football is a complex and many factors can lead to the goal. Research about the goal shows exist critical moments in the match, where the goals happen more frequently. Objective: to Analyze the temporal incidence of goals in Copa Libertadores 2014. Materials and Methods: The study is descriptive. Analyzed 126 sets of 32 participating teams. The data collection was carried out directly from the CONMBOL Web site. Each goal was classified according to its incidence in one of six periods: 0-15 minutes; 16-30 minutes; 31-45 minutes (including additions; 46-60 minutes; 61-75 minutes and 76-90 (including additions. Results: Were scored 324 goals in 126 games, getting an average of 2.5 goals per game. The goals were carried out mostly in the second half of the matches highlighted by the last fifteen minutes of the game where 25.31% (n = 82 of goals. Discussion: Marques Junior (2015, in his review of the evidence about the goal in football, found that 55% of goals happen in the second half. In 2014 Copa Libertadores, 25.31% of goals happened in the last 15 minutes. This evidence goes against the results of the literature. Tactical, technical factors, physical, nutritional and psychological may be leading to these results. Conclusion: Most goals occurred in the second stage of the match with emphasis in the last fifteen minutes of the game.evidence on the football goal.

Symbolic and Sub-Symbolic Robotic Intelligence Control System (SS-RICS) Users Manual

Science.gov (United States)

2017-10-01

representations to drive intelligent systems, and the second focuses on a mathematical approach using distributed representations constructed with structures...3.1.1 Zip File • Extract the files from the zip file to a directory on your computer . • Open My Computer . • Browse to the directory where you...instructions. 3.1.2 CD • Open My Computer . • Browse to the CD-ROM drive on your computer . • Find the setup.exe file. Approved for public release

Truckee Meadows (Reno-Sparks Metropolitan Area) Nevada. Documentation Report

Science.gov (United States)

1983-10-01

borehole. (10) Borehole No. 7 and borehole Nos. 9 through 14 were not drilled to a depth of 20 feet because gravel was encountered, rendering both...through the Washo and on to the Maidu ( Heizer and Whipple 1917:58). 4. H.[ST0RIC.. B..KGR.UND a. The first non-Ind:i.ans known to visit what is now the...Reno, University of Nevada. 32 pp. Heizer , Robert F. & M. A. Whipply 1971 The California Indians. Berkeley, University of California Press. 619 pp

Designing for user engagement

CERN Document Server

Geisler, Cheryl

2013-01-01

Designing for User Engagement on the Web: 10 Basic Principles is concerned with making user experience engaging. The cascade of social web applications we are now familiar with - blogs, consumer reviews, wikis, and social networking - are all engaging experiences. But engagement is an increasingly common goal in business and productivity environments as well. This book provides a foundation for all those seeking to design engaging user experiences rich in communication and interaction. Combining a handbook on basic principles with case studies, it provides readers with a ric

AMERICAN MANUFACTURING, AMERICAN TECHNOLOGY AND THE LABOR QUESTION AT THE PARIS EXPOSITION UNIVERSELLE OF 1867

Directory of Open Access Journals (Sweden)

Gregory Zieren

2004-01-01

Full Text Available The Paris Exposition Universelle of 1867 was devoted to the theme, “The History of Labor,” and awarded special prizes to firms with paternalistic labor policies to promote harmony between workers and employers. The guiding spirit of the Exposition and its labor theme was the French social thinker, Frédéric Le Play. American technology was a second trend on view at the Exposition, and American firms, including the Pacific Mills of Lawrence,MA won gold medals and international recognition.

La codificació del gallec o el pèndol que no s'atura

OpenAIRE

Díaz Fouces, Oscar

2004-01-01

L'autor presenta alguns dels elements més significatius de la polèmica per la codificació ortogràfica de la llengua gallegoportuguesa a Galícia, com també alguns instruments teòrics per analitzar aquesta mena de processos, especialment quan afecten les minories exoglòssiques. The author sets out some of the most significant elements within the controversy of the orthographical codification of the Galician-Portuguese language in Galicia, as well as certain theoretical instruments used in an...

L'Hemisferic: Una ventana al mundo

Directory of Open Access Journals (Sweden)

Calatrava Valls, Santiago

2000-12-01

Full Text Available The "Hemisféric-Planetario" building is located in the center line East-West of the "Ciudad de las Artes y las Ciencias" complex, flanked by two rectangular lakes, in the north and in the south, respectively. In the East side we can find a promenade between the Museum and its south lake. Nevertheless its West side is virtual. and located in the area of the "Hermanos Marista 's" viaducto The building is visited, daily, by about 3.000 people, distributed between its 8 duties. The showing room holds 321 seats, four of those for wheel-chairs. The building has a possible room of 999 people (at the same time.El edificio Hemisféric-Planetarío está situado sobre el eje Este-Oeste del complejo de la Ciudad de las Artes y las Ciencias; está flanqueado por dos estanques rectangulares, al Norte y al Sur, respectivamente. Por el Este, un paseo limita la parcela con el Museo y su estanque Sur. El limite Oeste, sin embargo. es virtual y se encuentra en la proyección del viaducto de Hermanos Maristas. Este edificio es visitado diariamente por unos 3.000 personas, distribuyéndose en 8 funciones. La sala de proyección dispone de 321 butacas, con posibilidad de alojar 4 sillas de ruedas. La capacidad de acogida del edificio (al mismo tiempo es de 999 personas.

Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing

Energy Technology Data Exchange (ETDEWEB)

Champagne, Devin P., E-mail: devin.champagne@uvm.edu; Shockett, Penny E., E-mail: pshockett@selu.edu

2014-03-15

Highlights: • Examines illegitimate V(D)J deletion junctions in Notch1 and Bcl11b. • Suggests little influence of deletions alone on clonal outgrowth in wild-type mice. • No age or sex biases in frequency, clonality, or junctional processing observed. • Contrasts with previous results at TCRβ and HPRT1 loci. • Deletions in Bcl11b may be tolerated more easily than those in Notch1. - Abstract: Illegitimate V(D)J recombination at oncogenes and tumor suppressor genes is implicated in formation of several T cell malignancies. Notch1 and Bcl11b, genes involved in developing T cell specification, selection, proliferation, and survival, were previously shown to contain hotspots for deletional illegitimate V(D)J recombination associated with radiation-induced thymic lymphoma. Interestingly, these deletions were also observed in wild-type animals. In this study, we conducted frequency, clonality, and junctional processing analyses of Notch1 and Bcl11b deletions during mouse development and compared results to published analyses of authentic V(D)J rearrangements at the T cell receptor beta (TCRβ) locus and illegitimate V(D)J deletions observed at the human, nonimmune HPRT1 locus not involved in T cell malignancies. We detect deletions in Notch1 and Bcl11b in thymic and splenic T cell populations, consistent with cells bearing deletions in the circulating lymphocyte pool. Deletions in thymus can occur in utero, increase in frequency between fetal and postnatal stages, are detected at all ages examined between fetal and 7 months, exhibit only limited clonality (contrasting with previous results in radiation-sensitive mouse strains), and consistent with previous reports are more frequent in Bcl11b, partially explained by relatively high Recombination Signal Information Content (RIC) scores. Deletion junctions in Bcl11b exhibit greater germline nucleotide loss, while in Notch1 palindromic (P) nucleotides are more abundant, although average P nucleotide length is

Identidade narrativa e identidade pessoal. Uma abordagem da filosofia de Paul Ricoeur

OpenAIRE

Fernandes, Sara Margarida de Matos Roma

2009-01-01

O presente artigo tem o objectivo duplo de reflectir sobre o conceito de identidade narrativa no pensamento de Paul Ricœur e o de avaliar a sua contribuição para a resolução do problema filosófico da identidade pessoal. Para o concretizar, o artigo procurará desenvolver as teses seguintes: 1) a identidade narrativa resulta da permanente dialéctica entre o carácter (mesmidade, idem) e a ipseidade (constância, ipse), ou seja, entre a capacidade do sujeito se referir continuamente a si durante a...

Early Photometric and Spectral Evolution of Nova Cygni 2014 (V2659 Cyg

Directory of Open Access Journals (Sweden)

Burlak M. A.

2015-12-01

Full Text Available We present optical spectroscopic and UBV (RIC photometric observations of Nova Cygni 2014 (V2659 Cyg from its rebrightening to the nebular stage. After the first maximum, the nova underwent several irregular flare-like rebrightenings, with amplitudes up to two magnitudes, accompanied with spectral changes. During the bright state, forbidden lines became weaker; the absorption components of Balmer, He I, Fe II, N I, N II, O I lines strengthened, indicating an increase in the density and mass-loss rate in the form of a wind.

Atelier : La part de fiction dans le cinéma documentaire

Directory of Open Access Journals (Sweden)

2009-12-01

Full Text Available Cet atelier du Lhivic a permis d’examiner la dimension fictionnelle du style documentaire. On a abordé ce sujet pragmatiquement et dans une optique interdisciplinaire, à partir d’extraits de films documentaires et de textes (de Baecque, Delage, Kracauer, Ricœur, etc.. Ces problématiques renvoient directement à celles de l’écriture de l’histoire, discipline dont on interroge particulièrement depuis le tournant linguistique les modes de mise en récit. Tout l’enjeu était alors de ne pas utilise...

Air quality in schools and children's exposure to particulate pollution in Barcelona

OpenAIRE

Rivas Lara, Ioar

2015-01-01

L'exposició als contaminants atmosfèrics s'ha relacionat amb efectes negatius a la salut i els infants constitueixen un subgrup de la població particularment vulnerable. Es determinà la qualitat de l'aire a l'interior i exterior de 39 escoles de Barcelona i Sant Cugat del Vallès. El mateixos contaminants mesurats a les escoles també es monitoritzaren a una estació de fons urbà a Barcelona (UB-PR). Les concentracions de carboni negre equivalent (EBC), NO2 i partícules ultrafines (UFP) mostrare...

Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia

DEFF Research Database (Denmark)

Baron, F; Labopin, M; Niederwieser, D

2012-01-01

This report investigated the impact of graft-versus-host disease (GVHD) on transplantation outcomes in 1859 acute myeloid leukemia patients given allogeneic peripheral blood stem cells after reduced-intensity conditioning (RIC allo-SCT). Grade I acute GVHD was associated with a lower risk...... of relapse (hazards ratio (HR)=0.7, P=0.02) translating into a trend for better overall survival (OS; HR=1.3; P=0.07). Grade II acute GVHD had no net impact on OS, while grade III-IV acute GVHD was associated with a worse OS (HR=0.4, P...

L'escriptura i el llibre a la Catalunya Central als segles XIII i XIV

OpenAIRE

Torras i Cortina, Miquel

2004-01-01

Consultable des del TDX Títol obtingut de la portada digitalitzada Aquesta investigació reconstrueix la vida cultural de la ciutat de Manresa, a la Catalunya Central, al llarg dels segles XIII i XIV, amb el còdex baixmedieval com a fil conductor. L'estudi es basa en l'anàlisi de 305 documents amb mencions libràries (editats conjuntament), pràcticament tots ells inèdits, que procedeixen d'un buidatge exhaustiu dels fons notarials que custodien l'Arxiu Històric Comarcal de Manresa i l'Arx...

Economics of Internet interdomain interconnections

OpenAIRE

Castro Arribas, Ignacio de

2015-01-01

Aquesta tesi estudia els aspectes econòmics de la interconnexió entre Ases, identifica desafiaments que amenacen el futur d'Internet i proposa solucions per resoldre'ls. Primerament vam realitzar el primer estudi analític i empíric sobre el peering remot, un tipus emergent d'interconnexió que relaxa les limitacions geogràfiques dels Ases i facilita interconnexions a un menor cost. Després vam presentar CIPT i T4P, dos nous tipus d'interconnexions que redueixen els costos d'interconnexió entre...

Between Classicism and Modernity:Eric Rohmer on urban change

OpenAIRE

Schmid, Marion

2015-01-01

A director at the crossroads of the arts, Éric Rohmer took a keen interest in the urban transformations France underwent in the course of the twentieth century, in particular the post-war villes nouvelles project launched by the Gaullist government in 1965. In a programmatic article on the relationship between cinema and architecture, followed by a series of television documentaries from the 1960s and ’70s as well as two features – Les Nuits de la pleine lune (1984) and L’Ami de mon amie (198...

Introduction : sur les traces de Julian Pitt-Rivers en Andalousie

Directory of Open Access Journals (Sweden)

Antoinette Molinié

2008-07-01

Full Text Available Je voudrais avant tout remercier Françoise Pitt-Rivers de l’honneur et de la confiance faits au Laboratoire d’ethnologie et de sociologie comparative en attribuant à la Bibliothèque Éric-de-Dampierre et à sa directrice Marie-Dominique Mouton la responsabilité des archives de son époux. Cette acquisition a permis d’ouvrir des perspectives nouvelles à la construction d’un véritable objet ethnologique à partir d’archives ethnographiques, soit le projet essentiel de notre programme d’aci. Nous a...

Gestión documental, febrero 2010

OpenAIRE

Bustelo Ruesta, Carlota; García Morales, Elisa

2010-01-01

La gestió documental té com a finalitat assegurar una atenció adequada als documents creats, rebuts o gestionats per una organització com a prova de les activitats realitzades, preservant-los durant el temps què sigui necessari. Aquesta assignatura pretén proporcionar els coneixements teòrics i pràctics necessaris per a analitzar, dissenyar i implementar un sistema de gestió documental. Per aquesta raó, es centra en la gestió dels documents que una organització manté com a resultat dels seus ...

Relacions tòxiques : Adolescència i dependència afectiva. Causes i conseqüències.

OpenAIRE

Clemente Hernández, Paula

2015-01-01

Les relacions tòxiques entre adolescents i joves són una realitat inqüestionable en el nostre entorn. Això xoca amb una suposada llibertat femenina sexual sense precedents. No obstant això, comportaments abusius, ruptures i retrobaments cíclics, o relacions basades en la dependència extrema dominen la societat. Aquest treball pretén treballar la realitat de les relacions tòxiques com a concepte i introduir-lo com a gran problema social. Per poder, a partir del recull teòric i l'entrevista amb...

PARALELO ENTRE LA ACTIVIDAD Y LA SUSTANCIA ADICTIVA DESDE UN ENFOQUE SOCIAL Y SUS POSIBLES TRATAMIENTOS

OpenAIRE

Alan Herzberg; Viviana Messina; Diego Moreno; Natalia Olmedo; Romina Pitronello; Francisca Roman

2007-01-01

El tema de las adicciones ha sido abordado históric amente por la literatura desde múltiples puntos de vista, sin embargo en esta investigación bibliográfica nuestra intenci ón es dimensionar las teorías sobre el origen de la s adicciones, considerando la complementariedad teórica para la q ue se presta el tema, permitiendo un paralelo con l as terapias psicoanalíticas y la visión freudiana. Por otro lado están los tipos de adicción, entre lo s q...

Anàlisi de la blockchain de Bitcoin

OpenAIRE

Plaza Rodríguez, Ferran

2016-01-01

Bitcoin, el conegut sistema de criptomoneda digital distribuït, s'ha estès considerablement en els dos últims anys. El gran volum de moviments monetaris que ha sofert fa que s'acumulin ja gairebé 80Gb de dades de transaccions registrades en l'històric públic, conegut com blockchain. Existeix una petita varietat de projectes open source dissenyats per llegir aquestes dades i representar-les en altres bases de dades per realitzar estudis sobre elles. La majoria d'aquests projectes obliguen a co...

Plan estratégico para el desarrollo del turismo rural comunitario en la región Cusco

OpenAIRE

Sepúlveda Medina, Hollman; Basurto Zapata, Rafael; Vizcarra Gutiérrez, Yuri

2010-01-01

El turismo es una de las actividades económicas que ha tenido un crecimiento importante en los últimos años, convirtiendo a esta industria atractiva para su desarrollo en países con potencial turístico, como el Perú. El turismo rural comunitario es una alternativa dentro de la industria del turismo para el desarrollo de las comunidades rurales que mediante una organización adecuada, les permite aprovechar el entorno y específicamente los recursos turísticos con que cuentan. En Latinoaméric...

Quina Agenda 21?

OpenAIRE

García, Ernest

2002-01-01

El programa definit a la Cimera de Rio s'ha desenvolupat amb grans dificultats, augmentades encara més per la dinàmica de mundialització dels mercats. La idea central d'aquest programa, el desenvolupament sostenible, no ha trobat encara una definició conceptual lliure d'equívocs. Una primera fase de debats teòrics ha donat pas a una sèrie d'intents d'elaborar esquemes operacionals, amb la consegüent proliferació de sistemes d'indicadors i mesures integrades, sovint divergents i incompatibles....

Evidence of Early Cultures in the Palpa Valleys on the South coast of Perú

OpenAIRE

Reindel, Markus; Isla, Johny A.

2012-01-01

After the pioneering work of Julio C. Tello, Frédéric Engel and John H. Rowe on the Formative and Preceramic periods, few advances have been made in the investigation of early cultural developments on the south coast of Perú. This is especially true for the Río Grande de Nasca drainage, where there is a lack of data regarding early human occupation. The Nasca-Palpa Archaeological Project aims to reconstruct the human occupation of the Palpa valleys during all Prehispanic periods. In this arti...

Joves i estructura social

OpenAIRE

Merino Pareja, Rafael

2008-01-01

Ubicar els joves en l’estructura social no és un tema fàcil. Bàsicament tenim dos tipus de problemes, un conceptual i un altre metodològic. Tenim problemes per definir el concepte de joventut, i el canvi social d’una societat industrial relativament estable a una societat postindustrial, del coneixement, del risc, informacional o com se li vulgui dir, ha agreujat considerablement els esforços teòrics per entendre el jovent. Tenim problemes per mesurar, per operativitzar els conceptes. Tot i q...

Les màquines del futur pensaran i sentiran

OpenAIRE

Vallverdú, Jordi,

2014-01-01

Aquest any, la revista International Journal of Synthetic Emotions, líder internacional en l’estudi de les emocions artificials, ha editat dos números especials dedicats a la reflexió sobre emocions, cognició i computació, en honor a Alan Turing, el creador de la intel·ligència artificial i de les computadores i l'expert que va fer possible desxifrar els codis de la màquina Enigma. Hi han contribuït teòrics de la computació, programadors de conversadors artificials i enginyers que treballen p...

Reflexions sociològiques figuratives i de procés sobre l’esport i la globalització: algunes observacions conceptuals i teòriques, amb especial referència al futbol

OpenAIRE

Dunning, Eric

2009-01-01

Aquest article es divideix en tres parts. La primera consisteix en un comentari conceptual teòric sobre la globalització i en diversos exemples del món globalitzat de l’esport; la segona és un comentari sobre el desenvolupament i l’extensió global del futbol; i la tercera exposa el comentari d’algunes patologies relacionades amb l’esport. Tot al llarg de l’article s’aplica l’enfocament sociològic figuratiu i de procés desenvolupat per Norbert Elias. En resum, aquest treball és fonamentalment ...

Evaluación de una solución gluco-electrolítica isotónica e isoclorada propuesta como recurso único a emplear en la rehidratación intravenosa a ritmo genérico de las distintas deshidrataciones por pérdidas digestivas en la edad pediátrica

OpenAIRE

Jiménez Buselo, María Teresa

2015-01-01

La rehidratación intravenosa (RIV) es a menudo inevitable cuando hay impedimento absoluto para satisfacer la deseable rehidratación oral (RHO). Coexisten históricamente dos modalidades de rehidratación intravenosa (RIV) en Pediatría: la convencional (RIC), basada en los estudios de Darrow (1949), Holliday y Segar (1957), y la llamada “rápida” (RIR), fundamentada en los de Hirschhorn (1968), y Rahman (1979), bajo cuya denominación se han publicado métodos muy dispares. Cada una ofrece alguna v...

MOMFER : una eina de cerca de motius folklòrics en el context de les humanitats digitals

Directory of Open Access Journals (Sweden)

Ardanuy Baró, Jordi

2016-06-01

significant role in processes such as scanning, but also in training and dissemination of resources. Folklore as a discipline of humanities is not exempt from this evolution. This is the context where MOMFER is analyzed, an online resource that substantially improves the use of Thompson's Motif-Index of Folk Literature. However, considering the ambitious goal for which the tool forms the basis of a comprehensive universal index, leadership will be required; and surely, to enable or to develop linked spaces of virtual collaboration.

Reading Research Utilization Project: An RIC Project for Teachers and Other Field Personnel.

Science.gov (United States)

District of Columbia Public Schools, Washington, DC. Dept. of Research and Evaluation.

This is the final report of the Reading Research Utilization Project (RUP) which was funded by the U.S. Office of Education from July, 1971 to June, 1973. The purpose of the RUP was to encourage the translation of research, particularly reading research, into practice in 16 target elementary schools in Washington, D.C. RUP was a school information…

MoDERN mANAGEmENt oF pAEDiAtRic buRNs

African Journals Online (AJOL)

2011-01-01

Jan 1, 2011 ... The majority of childhood burns in SA are treated by non-specialists, with referrals to ... Ice or iced water may increase the depth of the burn.7 Care must be taken not to .... •Full thickness- white, grey, painless. •Rule of nines.

MoDERN mANAGEmENt oF pAEDiAtRic buRNs

African Journals Online (AJOL)

2011-01-01

Jan 1, 2011 ... are the leading cause of non-natural death in infants and children under 5 years and ... Informal housing, overcrowding and lack of electricity are underlying problems.4 ..... support to meet the calorie and protein requirements ...

Le roman sans événements : 'Oreille rouge' d’Éric Chevillard

Directory of Open Access Journals (Sweden)

Anna Maziarczyk

2013-01-01

Full Text Available Even though absurd humour and surreal scenes are at first sight the characteristic elements of Eric Chevillard’s style, it is an oversimplification to consider his novels as mere literary jokes. The appeal of this literature stems from the light and witty manner in which it transforms outdated novelistic conventions, deconstructs classic narrative strategies and refuses to fulfill the reader’s expectations. This article seeks to analyse minimal narration, an unusual mode of writing for Chevillard, in Oreille rouge: just like narrative excess, typical of his other works, it results in dematerialisation of the plot and redefinition of the novelistic structure.

Berkeley 51 Kümesinin Temel ve Astrofiziksel Parametrelerinin Belirlenmesi

Directory of Open Access Journals (Sweden)

İnci Akkaya Oralhan

2016-10-01

Full Text Available Galaksimizin birinci çeyreğinde bulunan ve daha önce çok az çalışılmış açık yıldız kümelerinden biri olan Berkeley 51 kümesinin temel astrofiziksel ve yapısal parametreleri CCD UBV(RIC ve 2MASS JHKS verileri kullanılarak elde edilmiştir. Kümeye ait CCD UBV(RIC verileri Meksika’da bulunan San Pedro Martir Ulusal Gözlemevi’nden 84cm’lik teleskop ile alınmıştır. Küme üyeliklerinin belirlenmesinde ise PPMXL kataloğundaki öz hareket verileri kullanılmıştır. Buna küre bu küme için elde edilen limit yarıçap Rlim=2.5 yay dakikası, kızarma E(B-V=0.85±0.05 kadir, E(J-H=0.28±0.02 kadir, uzaklık modülü DM=(m-M0=10.66±0.04 pc, uzaklığı d=1355±27 pc ve logaritmik yaş log(A=9.54±0.03 Myıl olarak bulunmuştur. Küme için ilk kez bulunan metal ve ağır element bolluğu ise sırasıyla [Fe/H]=-0.38 ve Z=0.006 olarak elde edilmiştir.Anahtar kelimeler: Açık yıldız kümeleri-Berkeley 51

ALLOGENEIC TRANSPLANTATION FOR CHRONIC LYMPHOCYTIC LEUKEMIA

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Patrizia Chiusolo

2010-05-01

Full Text Available

Even if Chronic lymphocytic leukemia (CLL often has an indolent behavior with good responsiveness to cytoreductive treatment, about 20% of the patients, so called "poor-risk" patients, show an aggressive course and die within a few years despite early intensive therapies. Criteria for poor-risk disease according to the European Bone Marrow Transplantation (EBMT CLL Transplant Consensus are: purine analogue refractoriness, early relapse after purine analogue combination therapy, CLL with p53 lesion requiring treatment.

Allogeneic transplant has potential curative role in CLL, however burden with very  high transplant related mortality (TRM rates of 38-50%:

A major advance in reducing the short-term morbidity and mortality of allogeneic stem cell transplantation (SCT has been the introduction of non-myeloablative or reduced intensity conditioning (RIC regimens to allow engraftment of allogeneic stem cells. There is no doubt that the crucial therapeutic principle of allo-SCT in CLL is graft versus leukemia (GVL activity.

The major complications of allogeneic SCT in CLL are: chronic graft-versus-host-disease (GVHD affecting quality of life, high graft rejection and infection rates rates correlated with preexisting immunosuppression. Disease relapse remains the major cause of failure after RIC allo-HCT in CLL patients.

Sensitive minimal residual disease (MRD quantification has strong prognostic impact after transplant.

L’histoire entre la guerre des mémoires et la Justice

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François Dosse

2017-07-01

Full Text Available La question se pose de savoir si la Justice est capable de réparer le tragique de l’histoire. François Dosse situe son analyse sur l’axe pragmatique de la préoccupation citoyenne exprimée par Ricœur, dès les premières lignes de La mémoire, l’histoire, l’oubli, lorsqu’il se dit troublé par le trop de mémoire ici et le trop d’oubli ailleurs. On assiste en effet à une judiciarisation progressive de la discipline historique. Elle se traduit par une inquiétante inflation mémorielle depuis la loi Gayssot de 1990. La fonction du juge et de l’historien a certes des points communs, comme l’a montré Marc Bloch dans Apologie pour l’histoire ou Carlo Ginzburg dans Le juge et l’historien. Le juge d’instruction peut s’apparenter à l’historien, mais pas celui du siège qui doit rendre un jugement. Cette emprise progressive de la justice sur le passé a pour effet pervers une tentative de sanctuarisation des questions historiques. Ricœur nous aide à repenser les relations entre justice, histoire et mémoire en distinguant et en articulant ces diverses dimensions par un travail de clarification des concepts. Il permet de mieux articuler la fonction judiciaire, le travail de mémoire et l’opération historiographique en respectant la validité de chacune de ces dimensions.

Pojam lika u naratologiji

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Beáta Thomka

2014-03-01

Full Text Available Varying interpretations of fictional worlds or the diversity and frequent confusion of categories need not hinder our perception of the protagonist as a bundle of values, quality, organization, sounds, characteristics and signs. A character is a moral construct, the storage of representation; it can be revealed through his or her actions and must thus be understood and interpreted accordingly. It is a complex whole of imaginary constructs, even in those poetics of novels which – based on a disbelief in human integrity – separate the character from his/her mental psychic and social determinants and show him/her as a representative of a particular life situation. The lack of logic of narrative understanding in some twentieth-century narrative works begs for the recognition of metaphoric principles, which at the same time determines the strategy of the interpretation as well. The source of the theoretical orientation of this paper is based on the work and spiritual heritage of two thinkers. Bakhtin's view of the natural world as processual (questions concerning poetics, aesthetics and ethics and Ricœur's conception of narrative poetics and theory of uniformity is equally emphasized on the one hand as a construction of fictional characters and, on the other, as a possibility for the development of self-understanding. Apart from Ricœur's study Narrative Identity, Bakhtin's essay "Author and Hero" (emerged around 1920 served as an inspiration for a brief interpretation of two significant short stories, Flaubert's "A Simple Heart" and Mann's "Death in Venice".

Open Source Intelligence in a Networked World

CERN Document Server

Olcott, Anthony

2012-01-01

The amount of publicly and often freely available information is staggering. Yet, the intelligence community still continues to collect and use information in the same manner as during WWII, when the OSS set out to learn as much as possible about Nazi Germany and Imperial Japan by scrutinizing encyclopedias, guide books, and short-wave radio. Today, the supply of information is greater than any possible demand, and anyone can provide information. In effect, intelligence analysts are drowning in information. The book explains how to navigate this rising flood and make best use of these new, ric

Biodegradation of flax fiber reinforced poly lactic acid

CSIR Research Space (South Africa)

Kumar, R

2010-07-01

Full Text Available and dried in an oven at 60°C for 24 h to remove moisture. PLA pellets equivalent to 0.8 and 0.7 weight fractions of the nonwoven web and woven fabric, respectively were dissolved in chloroform. It is to be noted that nonwoven flax fiber requires higher... amount of PLA than woven ones. The dried nonwoven web/woven fabric was then placed inside a square metal frame mold of 15 cm×15 cm in dimensions and the PLA solution was poured over the nonwoven web or woven fab- ric. It was observed that 5 to 6 g...

Videojocs i subjectivitat femenina: Construcció de la desafecció

OpenAIRE

Torné Novell, Montse

2015-01-01

Aquest treball de recerca s'interessa per la construcció de la desafecció que senten les nenes pels videojocs. El focus se situa en les interaccions i les relacions afectives i de poder que s'estableixen en l'àmbit familiar entre mare i filla. L'objectiu principal és oferir un enfocament empíric i sistemàtic que permeti una nova manera d'abordar el fenomen de la desafecció pels videojocs com una àrea d'interès per a la psicologia social des d'una mirada performativa de la subjectivitat femeni...

Diseño del manual de clasificación y valoración de puestos por competencias para la Comisión de Tránsito del Ecuador .

OpenAIRE

Gallardo Carrera, Nicolás Patricio

2012-01-01

El presente trabajo investigativo indaga las particularidades en la elaboración de un Manual de Clasificación y Valoración de Puestos aplicado a la Agencia Nacional de Transito. Debido a la importancia que ha tomado la información en esta época, es fundamental que una Institución de carácter publico y con influencia a nivel nacional, cuente con la información suficiente y relevante para la toma de decisiones en la Gestión del Talento Humano, por lo cual y con base a la información históric...

El gran premi de Carol

OpenAIRE

Vara Hernández, Ainara

2016-01-01

Atrapada en el cos d'un home, la Carol Barangé, amb seixanta-nou anys, pren la decisió més important de la seva vida: deixar enrere la família, els amics i la seva posició social acomodada. Les trobades setmanals a Enfemme, un peculiar local clandestí, la convenceran per emprendre el viatge a Tailàndia i complir el seu somni: recuperar la seva joventut i reafirmar-se com a dona. Aficionada als cotxes, vol ser la primera dona transsexual en córrer el Rally Històric de Montecarlo. El trajecte q...

El rol de la mascota publicitària en l'era de la comunicació digital

OpenAIRE

Serra Leiva, Albert

2016-01-01

Aquest projecte pretén explorar el món de les mascotes publicitàries, com s'han relacionat amb la societat des de la seva creació i quins vincles s'hi estableixen actualment mitjançant les possibilitats comunicatives i multimèdia de les noves tecnologies. A més de fer un recorregut històric fins als seus orígens, aprofundirem també en com es pensa, es dissenya i s'articula una mascota corporativa com a pilar central d'un pla de comunicació d’una marca de galetes infantils ecològiques. Este...

Determinació de l'estructura tridimensional de la glicogen sintasa de "Pyrococcus abyssi"

OpenAIRE

Horcajada Garro, Cristina

2005-01-01

Les glicogen i midó sintases són glicosiltransferases que catalitzen la transferència de residus glucosil a l'extrem no reductor d'una cadena creixent d'un glucà α-1,4, retenint la configuració del carboni anomèric del sucre transferit. Aquest procès és central en el metabolisme energètic de la majoria d'èssers vius.En aquest treball presentem l'estructura cristal·logràfica de la glicogen sintasa de Pyrococcus abyssi (PaGS). Aquest enzim és termoestable i presenta una activitat màxima a ...

Règim no permanent en lleres de resposta ràpida. Aplicació del model HEC-RAS

OpenAIRE

Gayá Mascaró, Antoni

2004-01-01

El model numèric HEC-RAS és una eina d'ús públic força generalitzada en els càlculs de qualsevol projecte hidràulic. L'última versió d'aquest programa inclou un mòdul de càlcul en règim no permanent del qual no es té massa experiència pel que fa a les simulacions per hidrogrames d'avinguda curts. Aquesta tesina analitza el comportament d'aquest mòdul en la modelització de l'últim tram de la llera del riu Llobregat.

L'Info K, una eina de la televisió educativa : Estudi de l'agenda mediàtica de l'informatiu infantil

OpenAIRE

Vilardaga Mata, Maria

2014-01-01

El present treball descriu i comprèn el gènere informatiu especialitzat en nens a partir del cas empíric de l’Info K. La recerca es basa en un anàlisi de contingut sobre els assumptes que composen l'escaleta del programa i el posterior estudi avaluador del noticiari com a instrument de la televisió educativa. Per fer-ho, la investigació aplica els indicadors de qualitat d'espais audiovisuals dirigits a la infància i el primer nivell de la teoria de l'agenda-setting. L'Info K és una bona eina ...

Gunter, Valerie; Kroll-Smith, Steve, Volatile Places, A Sociology of Communities and Environmental Controversies

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Eduardo Basto

2012-10-01

Full Text Available Valerie Gunter, professora do Departamento de Sociologia da Universidade de Nova Orleães, e Steve Kroll-Smith, responsável pelo Departamento de Sociologia da Universidade da Carolina do Norte em Greensboro, apresentam este livro como sendo um guia de estudo de conflitos ambientais para estudantes de vários níveis. A colocação, no final de cada capítulo, de exercícios a realizar pelos estudantes reforça essa apresentação e ilude, de certa forma, a densidade das propostas metodológicas e teóric...

The Use of Management Accounting and Control Systems for the Enhancement of Organisational Outcomes

OpenAIRE

Malagueño de Santana, Ricardo

2011-01-01

L'objectiu d'aquesta tesi és examinar la mesura en que l'ús i l'estil d'ús dels sistemes de comptabilitat i control de gestió (MACS) per l'alta direcció contribueixen a la consecució dels resultats desitjables de l'organització. En aquesta investigació, el concepte de resultats d'organització s’explica en termes d'innovació de productes i del rendiment financer. Sobre la base de la teoria de contingència, aquesta recerca està organitzada en un compendi de quatre articles. Un treball teòric i ...

El nacionalismo cosmopolita. La referencia europea en la construcción nacional de Colombia 1845-1900

Directory of Open Access Journals (Sweden)

Vera Weiler

2001-01-01

Full Text Available Frédéric Martínez, El nacionalismo cosmopolita. La referencia europea en la construcción nacional de Colombia 1845-1900. Bogotá, Banco de la Repúblicallnstituto Francés de Estudios Andinos, 2001, 580 páginas. El libro, esperado desde que su autor presentara los primeros avances de su investigación en forma de ponencias y artículos, es la traducción de una tesis doctoral sustentada en la Sorbona en 1997 y publicada en su lengua original, por el Instituto Francés de Estudios Andinos.

Estudi del TDAH : Diagnòstic, avaluació i diferents tractaments d'intervenció

OpenAIRE

Gordon Lorente, Esther

2014-01-01

El present treball té com a objectiu principal realitzar un estudi teòric i científic sobre el Trastorn del Dèficit d'Atenció per Hiperactivitat (TDAH) des d'una perspectiva clínica. El propòsit és aprofundir en el coneixement del trastorn estudiant les variables diagnòstiques, el tipus d'avaluació a realitzar i els diferents tractaments d'intervenció existents; considerant la seva eficàcia i eficiència segons la validesa científica que presenten. A més, es qüestiona quin o quins enfocaments ...

Mathematical modelling of light-induced electric reaction of Cucurbita pepo L. leaves

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Jan Stolarek

2014-01-01

Full Text Available The bioelectRIc reactions of 14-16 day old plants of pumpkin (Cucurbita pepo L. and internodal cells of Nitellopsis obtusa to the action of visible and ultraviolet light (UV-C were studied. The possibility of analyzing the bioelectric reaction of pumpkin plants induced by visible light by means of mathematical modelling using a linear differential equation of the second order was considered. The solution of this equation (positive and negative functions can, in a sufficient way, reflect the participation of H+ and CI- ions in the generation of the photoelectric response in green plant cells.

La deportación y la separación familiar en la frontera San Diego-Tijuana

OpenAIRE

Ruiz Marrujo, Olivia

2017-01-01

Resumen: Las deportaciones de Estados Unidos han llevado a la separación de miles de padres y madres indocumentados de sus hijos. Basándose en el caso de la zona fronteriza San Diego-Tijuana, el objetivo de este artículo es explorar de qué manera la política migratoria llegó a permitir, y en momentos dictar, la separación familiar. El tema es abordado dentro de un marco analítico multidimensional y contextual centrado en el entrecruce de: la globalización de la expulsión; las fuerzas históric...

Interculturalidad en la educación superior. Los Estudios de Asia Oriental, los Estudios Hispánicos y la enseñanza de cultura

OpenAIRE

Lozano Méndez, Artur

2007-01-01

Primer estadi d'un projecte de recerca més ampli que pretén comparar les imatges de la cultura espanyola i japonesa que transmeten els Estudis Hispànics al Japó i els Estudis d'Àsia Oriental a Espanya, respectivament. Disquisició sobre el marc teòric dels estudis interculturals. Anàlisi de la creació de la imatge del Japó i de la distribució de la seva cultura internacionalment. Primer estadio de un proyecto de investigación más amplio que persigue comparar las imágenes de la cultura españ...

Com generar i finançar els nuclis d'innovació

OpenAIRE

Canela Campos, Enric I.

2014-01-01

La qüestió és com generar i finançar els nuclis d'innovació. A parer meu, la transferència, més enllà dels discursos, no és una prioritat. Les prioritats estan en els pressupostos i en l'assignació dels recursos humans. Només s'estan considerant, i no prou, els productes de l'activitat dels investigadors que podrien produir beneficis a curt termini. Jo no actuaria així. Estic convençut que amb pocs recursos i petits incentius a un teòric fons perdut als projectes dels investigadors, el coneix...

The Eventrement of Paris and the configuration of the Alphand-Davioud-Hittorff Paradigm on urban design

OpenAIRE

el Haddad, Marie

2017-01-01

A la primera meitat del segle XIX i en la Revolució Industrial, ciutats com París es van enfrontar a problemes de salut que els va causar el ràpid creixement de les indústries i les onades d’immigració de les zones rurals. Com a conseqüència, les ciutats, especialment el seu centre històric, van patir de congestió, superpoblació i higiene que van portar a diverses epidèmies. Per millorar les condicions higièniques, es van prendre mesures a través d’importants desenvolupaments urbans com la tr...

Jean-Philippe Costes, Les subversifs hollywoodiens. L’esprit critique du cinéma grand public

OpenAIRE

Dubois, François-Ronan

2015-01-01

À l’idée largement répandue que le cinéma grand public produit dans les studios d’Hollywood représente une machine de propagande étasunienne ou, à tout le moins, capitaliste, Jean-Philippe Costes entend opposer une lecture à contre-courant d’un corpus cinématographique fait de grands classiques et de grands oubliés. Hollywood, à ses yeux, ne saurait se réduire au véhicule médiatique d’une idéologie uniforme et oppressive qui serait, au gré des analyses, celle du capital, du patriotisme améric...

Un combat gagné d’avance.

Directory of Open Access Journals (Sweden)

Igor Moullier

2007-12-01

Full Text Available L’historien britannique Éric Hobsbawm jouit en France d’une popularité certaine, quoique se traduisant par un certain retard dans la traduction de ses ouvrages. The Invention of Tradition , une de ses contributions majeures, a été ainsi traduite récemment avec près d’un quart de siècle de retard. Echoes of the Marseillaise , rassemblant une série de conférences prononcées au lendemain du bicentenaire de la Révolution, fait à son tour l’objet d’une traduction française, ...

Well-Nourished Beauty. Culinary Symbolism in the Mass Culture of North Korea, 1960-2014

OpenAIRE

Gabroussenko, Tatiana

2015-01-01

En el discurs oficial del “paradís a la terra” propi de la República Popular Democràtica de Corea (RPDC), la qüestió del menjar va evolucionar deixant de ser un assumpte descuidat i minimitzat per esdevenir un símbol d’autenticitat nacional i lleialtat cap a el Líder. Aquest article pretén traçar el desenvolupament històric del simbolisme culinari en la cultura oficial de masses de Corea del Nord, a correlació amb les tendències canviants en la propaganda oficial de la RPDC....

Aproximacions teòriques al lideratge i implicacions en la gestió d'entorns VUCA

OpenAIRE

Góngora Marruedo, Javier

2017-01-01

Líders i organitzacions s'enfronten a un món volàtil, incert, complex i ambigu (VUCA), dominat per una globalització creixent i un avenç exponencial de les noves tecnologies de la informació. La manera com els líders gestionaven les seves organitzacions ja no resulta eficaç i han d¿adoptar nous models de lideratge que els ajudin a respondre a la impredictibilitat de l'entorn i trobar noves oportunitats. No obstant això, el desenvolupament teòric de nous models de lideratge adaptats a les exig...

Estratègies dels joves front de les necessitats. El cas de Mallorca

OpenAIRE

Ballester Brage, Lluís

2006-01-01

Es presenta un breu resum de les concepcions, metodologia i conclusions de la investigació desenvolupada com a tesi doctoral de sociologia i presentada a la Universitat Autònoma de Barcelona aquest any 2006. Els marcs de referència de l’anàlisi són la família i les formes de convivència, d’una banda; Mallorca, entesa com a societat diferenciada, per una altra. Però, abans dels estudis empírics, desenvolupats a partir de diverses fonts i amb múltiples metodologies complementàries (enfocament m...

Historia, circunstancia y libertad en la obra de Diego Abad de Santillán

OpenAIRE

Pérez de Blas, Fernando

2002-01-01

Partiendo de la lectura de la obra de Diego Abad de Santillán (1897-1983) pretendo mostrar un modelo de testimonio ético, que nacido de la libertad intenta dar consistencia práxica, real a un ideal nacido en el ámbito crítico-teórico. Este testimonio actúa de equilibrio superador de la tensión dialéctica que existe entre una realidad no acorde con el ideal (circunstancia) y el anhelo de una situación coherente con la utopía concebida. Este tenso entramado vital, que tiene su trasunto históric...

T-cell-depleted haploidentical stem cell transplantation results improve with time in adults with acute leukemia: A study from the Acute Leukemia Working Party of the European Society of Blood and Marrow Transplantation (EBMT).

Science.gov (United States)

Sestili, Simona; Labopin, Myriam; Ruggeri, Annalisa; Velardi, Andrea; Ciceri, Fabio; Maertens, Johan; Kanz, Lothar; Aversa, Franco; Lewalle, Philippe; Bunjes, Donald; Mohty, Mohamad; Nagler, Arnon

2018-05-15

T-cell-depleted, haploidentical transplantations (haplos) are commonly offered to patients who have high-risk, acute leukemia in the absence of a human leukocyte antigen (HLA) full-matched donor. To determine the effect of transplantation period, the authors divided 308 adults with de novo, acute leukemia who underwent T-cell-depleted haplo from 2005 to 2015 into 2 groups, according the year in which they underwent transplantation (2005-2011 [n = 191] and 2012-2015 [n = 117]). The median age was 41 years in patients who underwent transplantation before 2012 and 46 years in those who underwent transplantation after 2012 (P = .04). Most patients had acute myeloid leukemia (75% vs 69%; P = .26) and were in first complete remission (CR1) (55% vs 64%; P = .12) at the time of transplantation. The cumulative incidence of grade 2, 3, and 4 acute graft-versus-host disease (GvHD) and chronic GvHD were not different between the 2 groups (acute GvHD: 20% vs 22% cumulative incidence in patients who underwent haplo before and after 2012, respectively [P = .67]; chronic GvHD: 19% vs 11% cumulative incidence, respectively; P = .12]. The 2-year relapse incidence was 20%, the nonrelapse mortality (NRM) rate was 48%, and no difference was observed over time (21% vs 19% [P = .72] and 54% vs 38% [P = .11] for patients who underwent haplo before and after 2012, respectively). The main cause of NRM was infection. Haplo after 2012 (hazard ratio [HR], 0.57; P = .01), younger age (HR, 0.82; P = .02), and receipt of a reduced-intensity conditioning (RIC) regimen (HR, 0.53; P = .01) were independently associated with lower NRM. The 2-year overall survival rate was 36% and improved after 2012 (29% vs 47% before 2012; P = .02); and it was higher for patients who underwent transplantation in CR1 (41% vs 29%; P = .01). In multivariate analysis, haplo after 2012 (HR, 0.54; P = .003) and receipt of a RIC regimen (HR, 0.54; P = .005) were independently associated with better overall survival

Of watchdogs and safe havens: control mechanisms and/in online sacred spaces

Directory of Open Access Journals (Sweden)

Alexander Darius Ornella

2013-01-01

Full Text Available ‘Die große Schlacht. Der Hass des Satans auf Benedikt XVI. Non prae­valebunt’ is the headline of an article the Austrian-based and Catholic news portal, kath.net, published in early June 2012. It is about how badly and unfairly the media treat the Catholic Church and its official representatives in the wake of the so-called ‘Vatileaks’ scandal and it reasons that Satan is behind the attacks of the media, society, popular culture, on saintly figures such as Pope Benedict XVI. ‘Gegen die Diktatur des Relativismus’ is another article published on the same platform in the context of a conference hosted by the Catholic Heiligenkreuz monastery. On the forum kath.net, powerful language is employed to draw the faithful in, to make them feel themselves to be safe within a community of like-minded people in the midst of turmoil. News portals and message boards such as kath.net create safe spaces within a world whose culture, values, and morals are not only not understood but despised. The analysis is informed by critical discourse analysis and based on Paul Ricœur’s understanding of narratives and how narratives create worlds. As a first step, the concept of space and Ricœur’s understanding of narrative identity are discussed. After an introduction to the news portal kath.net, a close reading of some articles shows how these safe spaces are created and guarded. To conclude, a reflection on the implications of the self-understanding of kath.net and some of its user base on the understanding of hierarchy and the role of theology in the Church, is provided.

Les demandes d'enfermement dans la généralité de Rouen au xviiie siècle : le récit de vie comme objet d'Histoire

Directory of Open Access Journals (Sweden)

Élise Chopin-Tufel

2009-10-01

Full Text Available Á travers quelques exemples normands de la seconde moitié du xviiie siècle, cet article analyse la construction des dossiers de demandes d’enfermement et les raisons qui poussent les familles à demander des ordres du roi pour enfermer l’un des leurs. Ces documents présentent des particularités (manque de spontanéité, fragmentation des récits narratifs qui doivent être prises en compte dans leur étude. Ils sont cependant d’une grande richesse pour aborder les réseaux sociaux, les normes et transgressions dans la société normande prérévolutionnaire. Le concept d’identité narrative développé par Paul Ricœur enrichit l’étude de ces sources. Á travers la narration, les justiciables normands mobilisent en effet différentes identités qui renseignent sur les rapports qu’ils entretiennent avec le politique.Through Norman examples from the second half of the 18th century, this article analyses the structure of confinement requests cases and the reasons why families used lettres de cachet to lock up one of their folks. Those documents show particularities (a lack of spontaneity, a fragmentation in the narrative that must be considered when studying them. However they are very useful to study social networks as well as the standards and contraventions of this prerevolutionary Norman society. This concept of a 'narrative identity' as developped by Paul Ricœur enriches the study of these sources. Through narration, Normans who are to be tried use different identities, which give information about their relations with politics.

National inventory of anhyd ric carbonic emissions providing of fuels consumption as energy source

International Nuclear Information System (INIS)

1994-01-01

The Convention of the United Nations about Climatic Change, carried out in 1992, and whose ratification this being considerate d at level Parliament in the Republica Oriental del Uruguay, it has as objective to achieve the stabilization of the concentrations of gases of effect hot house in the atmosphere at a level that impedes interferences dangerous antropogenias. The National Direction of environment has carried out and Inventory of the Emissions of gas carbonic anhydride in the execution of the arisen commitments of the mentioned Convention. It being this the first step for the realization of a national inventory, which will not include the rest of the gases of effect hothouse controlled by the Protocols of Montreal. The inventory of the emissions carried out by the Division of Global and Regional Matters, it has been carried out for each one of the years understood in the period from 1987 to 1992 being studied the contribution of each sector of the national activity in the Emissions of carbonic anhydride.The results show that the total emissions estimated for Uruguay reach only the 6655 gigagrames of annual for the year 1992, being a light increase of the emission values among the years 1989 at 1992

ThEoLogy ANd RhEToRIC: REdEFININg ThE RELATIoNShIP ...

African Journals Online (AJOL)

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A possible Echinococcus granulosus calcified cyst found in a medieval adult female from the churchyard of Santo Domingo de Silos (Prádena del Rincón, Madrid, Spain).

Science.gov (United States)

Monge Calleja, Álvaro M; Sarkic, Natasa; López, Jesus Herrerín; Antunes, Wilson D T; Pereira, Manuel F C; Matos, António Pedro Alves de; Santos, Ana Luísa

2017-03-01

Calcification, or mineralisation, can occur as part of a natural process, or by pathological processes. The purpose of this work is to examine an unidentified semi-spherical and perforate hollow mass, found near the pelvis of an adult female, dated 12th-13th century AD, exhumed of the Church of Santo Domingo de Silos (Prádena del Ricón, Madrid, Spain). The mass was examined by SEM and Energy Dispersive X-Ray Spectroscopy. These procedures revealed a heterogeneous inner surface with both smooth and irregular areas. A larger spherical and several smaller crescent-shaped perforations were noticed. X-ray microanalysis revealed the presence of the elements C, K, P, Ca, Al, Si, Fe, and Mg. The co-localisation of Ca and P suggests that they may be combined in a mineral matrix, likely formed in vivo. Other minerals probably came from the soil, although Fe could be related to the presence of blood. The macroscopic and microscopic appearances, chemical composition, and location of the calcified mass point to a possible hydatid cyst from Echinococcus granulosus, common in agricultural populations. This study used a suite of analytical techniques that are useful in the diagnosis of unknown calcified masses and can, therefore, be recommended for use in future analytical work. Copyright © 2017 Elsevier Inc. All rights reserved.

Editorial

Directory of Open Access Journals (Sweden)

Zinchenko, Yury P.

2013-06-01

Full Text Available The educational reform is Russia is in full swing, so the section of Psychology of education and learning is the most widely presented in the current issue. The international collective of authors Frédéric Yvon, Ludmila A. Chaiguerova and Denise Shelley Newnham considers different interpretations of the works of Lev Vygotsky — famous psychologist and methodologist. The authors suggest original ways of incorporating Vygotsky’s ideas into the modern educational system. Dmitry A. Podolskiy presents his study of value hierarchy among students and adolescence in the article “Multimethod approach to measuring values in a school context: exploring the association between Congruence — Discrepancy Index (CODI and task commitment”. In the article “The role of reflection and reflexivity in the development of student’s abilities” Vladimir D. Shadrikov explores the role of reflection in the educational process. The group of authors headed by Nikolay E. Veraksa state that dialectical thinking is a specific line of cognitive development in children and adults and proves this statement by the empirical data (“The structural dialectical approach in psychology problematic and research results”.

INDIA, SCO AND BRICS IN MODERN GEOPOLITICS

Directory of Open Access Journals (Sweden)

Tatiana L. Shaumyan

2013-01-01

Full Text Available The first decade of the third millennium has witnessed the formation of newly forged associations, a substantial growth of regional organizations, an upsurge in their activity and also their increasing adaptability to globalization processes. A keen interest to participate in such regional alliances has been displayed by nations representing diverse structural systems, differing sizes of economy and various natural, economic, human and military potentials. Among these are both developed and developing states, great powers, neighboring states as well as those located on separate continents (India-Brazil-South Africa, Brazil-Russia-India-China-plus South Africa. The same state may decide to join one or several regional and sub-regional organizations as well as non-institutionalized groups. India has participated in such organizations and associations as SCO, SAARC, RIC, BIMSTEC and BRICS. Indian participation in the activities of regional and global organizations does not damage its independent foreign policy; its growing assertiveness as a world economic power occupies a special place in global politics. India determines its foreign policy and its relations with other world powers, with developed and developing countries alike, based on its national interests

Uso y cantidad de información de gráficos en materiales didácticos de Física

OpenAIRE

Idoyaga, Ignacio

2017-01-01

Se plantea un primer estudio de las representaciones gráficas presentes en el material didáctico de un curso de física universitaria, 279 en total. Se identificaron los tipos de representaciones gráficas. Se discriminaron los usos didácticos y científicos, y la cantidad de información intrínseca y extrínseca de los gráficos. La metodología propuesta recurrió a la estadística descriptiva e inferencial. Predominaron los gráficos cartesianos de uso didáctico expositivo y de uso científico teóric...

Pretractament amb hidròlisi parcial de residus lignocel·lulòsics

OpenAIRE

González i Anadón, Glòria

1985-01-01

Aquest resum recull el treball realitzat sobre la hidròlisi àcida de la fracció hemicel?lulòsica de residus agrícoles, com un pretractament de la cel?lulosa present, cara a la hidròlisi enzimàtica. S'ha treballat amb palla de blat, a la qual s'ha sotmès a un procés de mòlta i garbellat a fi d'aconseguir un substrat el més homogeni possible. Un cop seleccionades les variables d'operació, s'han dut a terme experiències a diferents concentracions d'àcid sulfíric i diverses tem...

El treball en equip. Docència i aprenentatge amb l'ajuda d'un joc de peces

OpenAIRE

Triadó i Ivern, Xavier Ma.; Aparicio, Pilar; Jaría Chacón, Natalia; Elasri Ejjaberi, Amal

2010-01-01

L'explicació de conceptes teòrics, que alhora són coneguts genèricament per a tothom, no són una tasca senzilla. Sobretot quan es volen sentar les bases correctes i desfer equívocs que venen provocats per la mateixa generalització del concepte, poden ser útils recursos que facin palès el que es vol explicar i que es distingueixin clarament el conceptes encertats i els equívocs. La innovació docent que es presenta té la intenció de mostrar la diferència entre el treball en grup i el treball en...

Liderazgo y estrés en organizaciones complejas

OpenAIRE

Di Grillo, Marcelo

2014-01-01

¿La “presión laboral” del líder sobre su equipo influye en el rendimiento? ¿Líderes amados o temidos? ¿Estrés y satisfacción laboral? Las evaluaciones de los subordinados sobre las acciones de sus jefes se correlacionan con: la satisfacción laboral y el nivel de estrés laboral. Se presenta un estudio cuantitativo sobre 212 casos. La evidencia corrobora la asociación entre indicadores de estrés e insatisfacción con el líder. Se identifican estresares y satisfactores. Se abordan la línea teóric...

Specifications for Construction of Channel and Jetty System Murrells Inlet Navigation Project Murrells Inlet, South Carolina.

Science.gov (United States)

1977-06-14

onIis oft’ h Ie ’I IS.J1 I aif the minori ty imanpower tit i I ia i lon’ ia t ot, hle font r~ic ta’ rec s or exceeds its commitmenC~t to thle goalIs for...Treated Piles V-3 5-12. Quality Control V-3 5-13. Payment for Weir Warning Markers V-4 5-14. Pulled Piles V-4 w w w w w w ". .... • _ ° .. i...indicated on the driving plan shall be no more than 6 inches for each pile. Excessive bending of piles to pull them into final position will not be

License - RMG | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available List Contact us RMG License License to Use This Database Last updated : 2013/08/07 You may use this database...se terms regarding the use of this database and the requirements you must follow in using this database. The license for this databas... Alike 2.1 Japan. If you use data from this database, please be sure attribute this database as follows: Ric...Japan is found here . With regard to this database, you are licensed to: freely access part or whole of this database..., and acquire data; freely redistribute part or whole of the data from this database; and freely create and distribute datab

Poder e gênero em Miguel Ángel Asturias, Érico Verissimo e Gioconda Belli

OpenAIRE

Oliveira, Amanda da Silva

2015-01-01

O objetivo dessa dissertação é o estudo dos temas poder e gênero em três romances latino-americanos: O Senhor Presidente, de Miguel Ángel Asturias; O Senhor Embaixador, de Erico Verissimo; e O País das mulheres, de Gioconda Belli. Tratando de definir os conceitos de campo literário da Guatemala, do Brasil e da Nicarágua, a partir do ano de publicação das obras estudadas, as análises textuais se direcionam à percepção de como o poder se estabelece sob forma de opressão nas ditaduras das Améric...

La représentation de la sexualité dans la littérature féminine du nouveau millénaire : le cas de Catherine Millet

OpenAIRE

Nathalie Dumas

2010-01-01

Frédéric Beigbeder, dans son dernier roman intitulé Windows on the World, en vient à la conclusion que, de nos jours, le Play-boy international n’est en fait plus qu’un célibataire en quête de jouissance, ne chassant que la femme superficielle ou la prostituée. Selon l’auteur, aujourd’hui le Play-boy international est une femme. Une Bridget Jones ou une Carrie Bradschaw de Sex and the City (Beigbeder, 178 et 231). Le type de femme qui fait peur, qui assume et expose sa féminité et son indépen...

Automatic image quantification strategies in clinical nuclear medicine and neuroradiology

OpenAIRE

Sampedro Santaló, Frederic

2017-01-01

Amb la revolució de la tecnologia digital d'obtenció d'imatges radiològiques i l'increment de la potència computacional, el camp de la quantificació d'imatges mèdiques ha sorgit. El fet de poder programar un ordinador per a que detecti patrons d'interès en imatges radiològiques i pugui derivar-ne d'aquests indicadors numèrics amb valor clínic fa que, sens dubte, aquest àmbit de coneixement tingui un gran potencial en entorns mèdics i de recerca. En aquesta tesi es presenten un conjunt de cont...

Eriçó de mar: Estudi antropològic, geolingüístic i etimològic

Directory of Open Access Journals (Sweden)

Antoni Corcoll Llobet

2013-01-01

Full Text Available   Els objectius bàsics d’aquest treball monogràfic sobre l’eriçó de mar és donar a conèixer els termes genèrics i aquells que fan referència a una o unes espècies en concret d’aquest animal marí, la seva distribució geogràfica, la seva vitalitat i la motivació semàntica o l’etimologia de tots aquests significants. Així mateix, faig esment de possibles castellanismes i d’algunes peculiaritats fonètiques que afecten diversos significants de l’eriçó de mar.

Espaço, imagem e memória: adensamento dos conteúdos coletivos à materialidade da cidade

OpenAIRE

Zaiatz Crestani, Andrei Mikhail; Martins de Araújo Klein, Regina Maria

2017-01-01

Resumo As relações socioespaciais conferem conteúdo ao espaço urbano e imprimem no tempo significados que se adensam materialmente. No percurso temporal-cronológico, relações tangíveis e intangíveis constroem a paisagem urbana tecendo memórias coletivas, que se endereçam a lugares da cidade. Neste trabalho, discute-se o processo de assentamento de significados e memória coletiva nos espaços urbanos e sua relação tanto com ações de gestão quanto com a apropriação populacional. O objeto empíric...

La Poética del "pathos" en la iconografía de la pintura mejicana del siglo XX

OpenAIRE

Medina Prado, Rebeca

2007-01-01

[spa] En este trabajo se investiga la "Poética del Pathos en la iconografía de la pintura mexicana del siglo XX". Uno de los motivos de dicha investigación ha sido la enorme expectación que se creó en México en la década de los años veinte del siglo XX frente al renacimiento artístico de la pintura mural y de caballete, creada bajo el patrocinio del Gobierno de México. El Ministro de Educación José Vasconcelos convocó a los pintores que se encontraban en Europa o Estados Unidos de Norteaméric...

Thèses de doctorat soutenues

Directory of Open Access Journals (Sweden)

2005-04-01

Full Text Available LEGRAND Stéphane, Le normal et l'anormal (une archéologie du concept de norme dans l'oeuvre de Michel Foucault. Thèse soutenue à l’Université de Lille III, le lundi 8 décembre 2003.Composition du jury :M. Etienne Balibar, Professeur émérite à l'Université de Paris X-NanterreM. Didier Deleule, Professeur à l'Université de Paris X-NanterreM. Frédéric Worms, Professeur à l'Université de Lille IIIM. Pierre Macherey, Professeur à l'Université de Lille III, Directeur de thèse. Nous nous efforçons ...

A tradução das legendas do filme Intouchables : análise da explicitação sob o viés do personagem Driss

OpenAIRE

Pimentel, Beatriz de Araujo Pereira Falcão

2014-01-01

A análise da explicitação da legendagem em Intouchables é realizada neste trabalho sob o viés do personagem principal do filme, Driss. O filme foi lançado em 2011, pelos diretores Olivier Nakache e Éric Toledano, e inspirado em um documentário intitulado À la vie et à la mort de Jean-Pierre Devillers de 2002. Trata-se também de uma adaptação fílmica do livro Le second souffle, uma autobiografia de Philippe Pozzo. Para esta análise, tem-se inicialmente uma fundamentação teórica sobre a explici...

Why turbulence sustains in supercritically stratified free atmosphere?

Science.gov (United States)

Zilitinkevich, Sergej

2016-04-01

It is widely believed that in very stable stratifications, at Richardson numbers (Ri) exceeding critical value Ric ˜ 0.25 turbulence decays and flow becomes laminar. This is so at low Reynolds numbers (Re), e.g., in lab experiments; but this is not true in very-high-Re geophysical flows. Free atmosphere and deep ocean are turbulent in spite of strongly supercritical stratifications: 1 role of negative buoyancy flux, Fb > 0, in turbulence energetics was treated in terms of the turbulent kinetic energy (TKE) budget equation and understood as just consumption of TKE by the buoyancy forces. This has led to the conclusion that sufficiently strong static stability causes the negative buoyancy flux sufficiently strong to exceed the TKE generation rate and thus to kill turbulence. However, considering TKE equation together with budget equation for turbulent potential energy (TPE proportional to the squared buoyancy fluctuations) shows that the role of Fb in turbulence energetics is nothing but conversion of TKE into TPE (Fb just quantifies the rate of this conversion); so that Fb does not affect total turbulent energy (TTE = TKE + TPE). Moreover, as follows from the buoyancy-flux budget equation, TPE generates positive (directed upward) buoyancy flux irrespective of the sign of the buoyancy gradient. Indeed, the warmer fluid particles (with positive buoyancy fluctuation) rise up, whereas the cooler particles sink down, so that both contribute to the positive buoyancy flux opposing to the usual, negative flux generated by mean buoyancy gradient. In this context, strengthening the negative buoyancy flux leads to decreasing TKE and increasing TPE. The latter enhances the counter-gradient share of the total flux, thus reduces |Fb| and, eventually, increases TKE. The above negative feedback was disregarded in the conventional concept of down-gradient turbulent transport. This mechanism imposes a limit on the maximal (independent of the buoyancy gradient) value of |Fb| and thus

AN ADVANCED OXIDATION PROCESS : FENTON PROCESS

Directory of Open Access Journals (Sweden)

Engin GÜRTEKİN

2008-03-01

Full Text Available Biological wastewater treatment is not effective treatment method if raw wastewater contains toxic and refractory organics. Advanced oxidation processes are applied before or after biological treatment for the detoxification and reclamation of this kind of wastewaters. The advanced oxidation processes are based on the formation of powerful hydroxyl radicals. Among advanced oxidation processes Fenton process is one of the most promising methods. Because application of Fenton process is simple and cost effective and also reaction occurs in a short time period. Fenton process is applied for many different proposes. In this study, Fenton process was evaluated as an advanced oxidation process in wastewater treatment.

Physics of intense, high energy radiation effects

International Nuclear Information System (INIS)

Hjalmarson, Harold Paul; Hartman, E. Frederick; Magyar, Rudolph J.; Crozier, Paul Stewart

2011-01-01

This document summarizes the work done in our three-year LDRD project titled 'Physics of Intense, High Energy Radiation Effects.' This LDRD is focused on electrical effects of ionizing radiation at high dose-rates. One major thrust throughout the project has been the radiation-induced conductivity (RIC) produced by the ionizing radiation. Another important consideration has been the electrical effect of dose-enhanced radiation. This transient effect can produce an electromagnetic pulse (EMP). The unifying theme of the project has been the dielectric function. This quantity contains much of the physics covered in this project. For example, the work on transient electrical effects in radiation-induced conductivity (RIC) has been a key focus for the work on the EMP effects. This physics in contained in the dielectric function, which can also be expressed as a conductivity. The transient defects created during a radiation event are also contained, in principle. The energy loss lead the hot electrons and holes is given by the stopping power of ionizing radiation. This information is given by the inverse dielectric function. Finally, the short time atomistic phenomena caused by ionizing radiation can also be considered to be contained within the dielectric function. During the LDRD, meetings about the work were held every week. These discussions involved theorists, experimentalists and engineers. These discussions branched out into the work done in other projects. For example, the work on EMP effects had influence on another project focused on such phenomena in gases. Furthermore, the physics of radiation detectors and radiation dosimeters was often discussed, and these discussions had impact on related projects. Some LDRD-related documents are now stored on a sharepoint site (https://sharepoint.sandia.gov/sites/LDRD-REMS/default.aspx). In the remainder of this document the work is described in catergories but there is much overlap between the atomistic calculations, the

Morphodynamic Modeling Using The SToRM Computational System

Science.gov (United States)

Simoes, F.

2016-12-01

The framework of the work presented here is the open source SToRM (System for Transport and River Modeling) eco-hydraulics modeling system, which is one of the models released with the iRIC hydraulic modeling graphical software package (http://i-ric.org/). SToRM has been applied to the simulation of various complex environmental problems, including natural waterways, steep channels with regime transition, and rapidly varying flood flows with wetting and drying fronts. In its previous version, however, channel bed was treated as static and the ability of simulating sediment transport rates or bed deformation was not included. The work presented here reports SToRM's newly developed extensions to expand the system's capability to calculate morphological changes in alluvial river systems. The sediment transport module of SToRM has been developed based on the general recognition that meaningful advances depend on physically solid formulations and robust and accurate numerical solution methods. The basic concepts of mass and momentum conservation are used, where the feedback mechanisms between the flow of water, the sediment in transport, and the bed changes are directly incorporated in the governing equations used in the mathematical model. This is accomplished via a non-capacity transport formulation based on the work of Cao et al. [Z. Cao et al., "Non-capacity or capacity model for fluvial sediment transport," Water Management, 165(WM4):193-211, 2012], where the governing equations are augmented with source/sink terms due to water-sediment interaction. The same unsteady, shock-capturing numerical schemes originally used in SToRM were adapted to the new physics, using a control volume formulation over unstructured computational grids. The presentation will include a brief overview of these methodologies, and the result of applications of the model to a number of relevant physical test cases with movable bed, where computational results are compared to experimental data.

L’église Saint-Michel de Lille : chronologie d’un chantier

Directory of Open Access Journals (Sweden)

Catherine Guillot

2012-04-01

Full Text Available Après le démantèlement des fortifications de Lille en 1858, un nouveau quartier est aménagé au sud de la ville, dont un des équipements importants est l’église Saint-Michel, construite entre 1868 et 1874 par l’architecte Alfred Coisel. Très bien documenté, son chantier dévoile un mobilier et un décor exemplaire par son homogénéité et par la place accordée à la peinture murale. Cette étude met en évidence, outre le rôle du peintre Alphonse Colas, des artistes méconnus comme Albéric Duyver et Marie Carin. L’iconographie, qui révèle un des plus importants cycles consacrés à l’archange saint Michel, est également extrêmement caractéristique de son temps.After the demolition of the fortifications at Lille, in 1858, a new quarter developed to the south of the city. One of the important features of this new neighbourhood was the Saint-Michel church, built between 1868 and 1874 to the designs of the architect Alfred Coisel. The building of this church is exceptionally well documented and reveals church furnishings and decoration of an exemplary nature in terms of homogeneity and the special place given over to mural paintings. This study underlines the role of the painter Alphonse Colas, but also the contribution of other, less well known artists such as Albéric Duyver and Marie Carin. The iconographical theme is one of the most important cycles of its time devoted to the archangel Saint Michel, and is highly characteristic of the period.

MacDUST - a powder diffraction package developed for the ''ADONE'' high resolution diffraction station

International Nuclear Information System (INIS)

Burattini, E.; Cappuccio, G.; Maistrelli, P.; Simeoni, S.

1993-01-01

A High Resolution Powder Diffraction Station (PO.DI.STA.) was installed at the beginning of 1991 on the ADONE-Wiggler magnet beam line. The station and the first powder diffraction spectra, collected with synchrotron radiation, were presented at the EPDIC-1 Conference. More details can also be found in. For this station, a very sophisticated software package ''MacDUST'' has been developed on an Apple Macintosh computer, using the Microsoft QuickBASIC compiler. It allows very easy and comfortable operations by means of a graphical user interface environment, typical of the Macintosh system. The package consists of five major programs. The main program, MacDIFF, performs all the graphic operations on the experimental data, including zooming, overlapping, cursor scanning and editing of patterns, control of output operations to printers and HPGL plotters. It also includes several analysis routines for data smoothing, a first derivative peak search algorithm, two background subtraction routines and two profile fitting programs: one based on the simplex method and the other on the Marquardt modification of a least-square algorithm. MacPDF and MacRIC are both dedicated to phase identification. The first program is an archive manager for searching, displaying and printing phase records; MacRIC is a graphic aided search-match program based on the Hanawalt algorithm. Mac3-DIM is a plot program, useful, e.g., for representing kinetics three dimensionally. MacRIET is a Macintosh version of the well known Rietveld refinement program. This version, besides conventional structure refinements, also allows the determination of micro structural parameters, i.e. micro strain and crystallite size. The program can also be used to simulate a pattern, once the structure of the compound is known. Taking advantage of the very intuitive Macintosh graphic user interface, through dialog and alert boxes, the program allows straightforward introduction and modification of the structure

Un brot de patologia bucal d'origen professional en el segle XIX: les necrosis fosforades dels maxil·lars

OpenAIRE

Luna Descalzo, Margarita; Corbella i Corbella, Jacint

1987-01-01

La patologia tòxica per fòsfor és ben coneguda i pot tenir aspectes diversos tant pel que fa a les formes clíniques derivades dels seus compostos com per la prevalença diferent en unes o al tres èpoques. Aquí volem descriure l'impacte que va tenir una forma que avui té un interès gairebé només històric en paisos de bon nivell sanitari, però que va constituir un punt candent de la patologia laboral del segle XIX. Es tracta de les lesions de la boca: mucosa, dents i sobre tot maxil·lars en treb...

Anàlisi de la resposta als tractaments combinats amb cisplatí en el càncer d'ovari: Factors implicats en la quimioresistència

OpenAIRE

Mir Cantos, Roser

2012-01-01

[cat] El càncer d’ovari (CaOV) és el quart càncer ginecològic més comú després del càncer de mama, endometri i cèrvix i representa la cinquena causa de mort per càncer en la població femenina. El CaOV epitelial (EOC) representa el 90% de tots els tumors ovàrics i és el més letal, amb una mort anual mundial de 115.000 dones, aproximadament. La majoria de les pacients amb CaOV es diagnostiquen quan la malaltia està molt avançada. El tractament es basa en citorreducció quirúrgica seguit de quimi...

Approach to ''Mind'' using functional neuroimaging

International Nuclear Information System (INIS)

Matsuda, Hiroshi

2006-01-01

This review mainly describes authors' recent investigations concerning neuroimages approaching to even human ''mind'' using techniques of PET, SPECT and functional MRI (fMRI). Progress of such studies greatly owes to the development of image statistics of the brain like statistical parametric mapping (www.fil.ion.ucl.ac.uk/spm/), and brain standards (www.mrc-cbu.cam.ac.uk/Imaging/mnispace.html, and ric.uthscsa.edu/projects/talairach daemon.html). The author discusses and presents images in cases of hallucinations (SPECT and H 2 15 O-PET), autism (SPECT), sleep, depression, and its therapy by transcaranial magnetic stimulation. These studies are expected to contribute to diagnosis and therapy of endogenous neurological disorders. (T.I.)

Approach to ''Mind'' using functional neuroimaging

Energy Technology Data Exchange (ETDEWEB)

Matsuda, Hiroshi [Saitama Medical School, Hospital, Moroyama, Saitama (Japan)

2006-05-15

This review mainly describes authors' recent investigations concerning neuroimages approaching to even human ''mind'' using techniques of PET, SPECT and functional MRI (fMRI). Progress of such studies greatly owes to the development of image statistics of the brain like statistical parametric mapping (www.fil.ion.ucl.ac.uk/spm/), and brain standards (www.mrc-cbu.cam.ac.uk/Imaging/mnispace.html, and ric.uthscsa.edu/projects/talairach daemon.html). The author discusses and presents images in cases of hallucinations (SPECT and H{sub 2}{sup 15}O-PET), autism (SPECT), sleep, depression, and its therapy by transcaranial magnetic stimulation. These studies are expected to contribute to diagnosis and therapy of endogenous neurological disorders. (T.I.)

REIGNY, Actes diplomatiques du XIIe siècle

Directory of Open Access Journals (Sweden)

Marlène Hélias-Baron

2008-07-01

Full Text Available Tout a commencé en 1104 quand deux ermites, Guérin et Gérard, ont obtenu d’Anséric chevalier d’Avallon et de Guy de Noyers la terre de Saint-Pierre située à proximité de Joux-la-Ville, dans le diocèse d’Autun. Leur aura de sainteté attira des disciples et leur communauté, installée en un lieu fort humide, justement appelé Fons humidus, Fontemoy, se transforma progressivement en un petit monastère. A la mort du deuxième abbé, Julien, au cours de l’année 1128, comme de nombreuses autres communa...

L’obra de Maragall traduïda a l’alemany

Directory of Open Access Journals (Sweden)

Ramon Farrés

2013-01-01

Goethe a Nietzsche. Però aquest interès del poeta català per la cultura germànica, contra el que es podria esperar, no ha donat com a resultat una recepció equivalent de la seva obra en l’àmbit cultural alemany. Passats cent anys de la seva mort, tan sols un grapat de poemes seus han estat recollits en versió alemanya en antologies i publicacions esparses. En aquest article s’estudien aquestes versions situant-les en el seu respectiu context històric i analitzant-les des del punt de vista de les estratègies de traducció aplicades pels diversos traductors, amb els seus encerts i les seves febleses.

La Generació del 27 : Maruja Mallo una dona ignorada

OpenAIRE

Garriga Tutusaus, Marina

2016-01-01

Ana María Gómez González, més tard, Maruja Mallo és l'exemplificació del triomf de la dona artista als anys 30. Malgrat el seu reconeixement en vida, cap dels intel·lectuals de la seva generació la va incloure mai en les seves memòries. En aquest treball es fa un repàs al context històric de l'artista, tot determinant els motius pels quals se la va apartar, tan a ella com a les seves contemporànies surrealistes, de la memòria col·lectiva i com la seva història és extrapolable al reconeixement...

KSC-04PD-0265

Science.gov (United States)

2004-01-01

KENNEDY SPACE CENTER, FLA. Congressman Dave Weldon listens to a presentation about the assets of the Central Florida Research Park, near Orlando, as the site of NASAs new Shared Services Center. Six sites around the U.S. are under consideration for location of the Center, which would centralize NASAs payroll, accounting, human resources, facilities and procurement offices that are now handled at each field center. The consolidation is part of the One NASA focus. Others attending the presentation included Congressman Tom Feeney, U.S. Representative Ric Keller, U.S. Senator Bill Nelson, Center Director Jim Kennedy and Pamella J. Dana, Ph.D., director, Office of Tourism, Trade, and Economic Development in Florida.

Thèses de doctorat soutenues en 2011

Directory of Open Access Journals (Sweden)

2012-03-01

Full Text Available Frédérique Bisiaux, Philosophie de la relation maternelle, de l'ontologie à la politique.Thèse soutenue le 7 décembre 2011 à l’Université Lille 3.Composition du juryFabienne Brugère, Professeur à l'Université de Bordeaux 3Philippe Sabot, Maître de conférences HDR à l'Université Lille 3François David Sebbah, Professeur à l’Université de technologie de CompiègneNathalie Zaccaï-Reyners, Professeur à l’Université Libre de BruxellesFrédéric Worms, Professeur à l’Université de Lille 3, Directeur de...

Control system for technological processes in tritium processing plants with process analysis

International Nuclear Information System (INIS)

Retevoi, Carmen Maria; Stefan, Iuliana; Balteanu, Ovidiu; Stefan, Liviu; Bucur, Ciprian

2005-01-01

Integration of a large variety of installations and equipment into a unitary system for controlling the technological process in tritium processing nuclear facilities appears to be a rather complex approach particularly when experimental or new technologies are developed. Ensuring a high degree of versatility allowing easy modifications in configurations and process parameters is a major requirement imposed on experimental installations. The large amount of data which must be processed, stored and easily accessed for subsequent analyses imposes development of a large information network based on a highly integrated system containing the acquisition, control and technological process analysis data as well as data base system. On such a basis integrated systems of computation and control able to conduct the technological process could be developed as well protection systems for cases of failures or break down. The integrated system responds to the control and security requirements in case of emergency and of the technological processes specific to the industry that processes radioactive or toxic substances with severe consequences in case of technological failure as in the case of tritium processing nuclear plant. In order to lower the risk technological failure of these processes an integrated software, data base and process analysis system are developed, which, based on identification algorithm of the important parameters for protection and security systems, will display the process evolution trend. The system was checked on a existing plant that includes a removal tritium unit, finally used in a nuclear power plant, by simulating the failure events as well as the process. The system will also include a complete data base monitoring all the parameters and a process analysis software for the main modules of the tritium processing plant, namely, isotope separation, catalytic purification and cryogenic distillation

Valors adverbials associats a la conjunció «que»: un estudi històric

Directory of Open Access Journals (Sweden)

Montserrat Batllori

2014-10-01

Full Text Available In this article we will discuss the causal and final adverbial values connected to the conjunction «que» in Catalan and in other Romanic languages. In the first part, we analyse the evolution of the complex conjunctions system in Classical Latin and the posterior oral usages which originated the preliterary Romanic languages. In the second, we study the causal and final subordinate propositions introduced by the nexus «que». As we will try to show, in Medieval Time the nexus que, as it happens today, was used to introduce both argumentative adjuncts, integrated in the predicate, and propositional adjuncts, more external and with a discursive function. Since the 13th century, the progressive substitution of que through other conjunctions will affect causal subordinate and final circumstantial propositions, but otherwise que will maintain its function to introduce discursive causality and finality, specially in oral language.

An Analysis of Spectra in the Red Rectangle Nebula Frédéric Zagury

Indian Academy of Sciences (India)

If the preceding paper emphasized the importance of atmospheric extinction for our understanding of ...... paper, the authors address several problems which concern the star system at the center of the nebula ... 1981), on-going research being ...

Die Kritik am transzendentalen Ich: Zu Sartres und Ricœurs Heidegger-Lektüren

Directory of Open Access Journals (Sweden)

Yvanka B. Raynova

2015-08-01

According Otto Pöggeler Heidegger's main brake with Husserl consists in his rejection of the tran-scendental constitution conceived as the life of an "absolute Cogito," replaced by Heidegger by the "factual life" from which phenomenology should always begin. The author of this paper argues that the problem about the starting point of phenomenology also appears later in the debates between Heidegger and Sartre, as well as in Ricoeur's Heidegger interpretation. Thus, the aim of the article is to analyze to what extent the positions of Heidegger, Sartre, and Ricoeur contradicts or even exclude each other, and to what extent they cross or eventually complement each other. The inquiry shows that Heidegger's accusation of Sartre's forgetting of the question about the sense of being of Dasein is unjustified. Equally untenable is Sartre's critique of Heidegger, that he had bypassed the Cogito as a starting point of the existential analysis, because Sartre's transcendence of the Cogito, which pretends to involve the transphenomenal Being, cannot be derived from it and risks to fall again in the trap of "phenomenalism," which Sartre reproached to Husserl. Ricoeur's Heidegger interpretation brings clarity to this discussion by pulling together the decentration of the subject and the limits of apodicticity of the Cogito. But his elaboration of the hermeneutics of the Self contains the risk of a hyperbolization of the role of language.

Effects of Organisational Characteristics on Contractors’ Construction Cash Flow Forecasting Capabilities

Directory of Open Access Journals (Sweden)

Muhammad Abdullahi

2017-01-01

Full Text Available Inadequate cash resources resulting from poor cash flows have been among the fundamental causes of construction project failures. Despite the panoply of cash flow forecasting (CFF tools, the cash flow performance of many construction firms have been reported to be poor due weak Cash flow forecasting (CFF process capabilities influenced by a couple of organisational characteristics. Although these organisational characteristics have been reported to significantly influence firms’ CFF process capabilities, the underlying mechanisms of how these organisational features and characteristics exhibit their specific influences on the cash flow forecasting capabilities of construction firms still remains underexplored. Therefore, this study aims at empirically exploring the influence of some organisation characteristics on the CFF process capabilities of construction firms. Best practices in CFF identified from the Royal Institute of Chartered Surveyors (RICS Cash Flow Forecasting (CFF guide were used to develop an assessment criteria used to assess the CFF capabilities of construction firms. The assessment was conducted through a questionnaire survey involving contracting organisations involved in both building and civil engineering works in Nigeria. The key best practices in CFF were ranked based on arithmetic mean value scores and averages were also determined for each of the four CFF components assessed (Knowledge and understanding CFF concepts and principles, Practical application, Practical considerations, and other Managerial issues. Hierarchical regression analysis was then used to examine the relationships between contractors’’ CFF process capabilities and some organisational characteristics. Results of the study reveals that organisational characteristics are strongly associated to firms’ abilities to prudently manage cash flows. The results of this study could serve as a basis for the strategic planning and improvement of Cash Flow

Markov Processes in Image Processing

Science.gov (United States)

Petrov, E. P.; Kharina, N. L.

2018-05-01

Digital images are used as an information carrier in different sciences and technologies. The aspiration to increase the number of bits in the image pixels for the purpose of obtaining more information is observed. In the paper, some methods of compression and contour detection on the basis of two-dimensional Markov chain are offered. Increasing the number of bits on the image pixels will allow one to allocate fine object details more precisely, but it significantly complicates image processing. The methods of image processing do not concede by the efficiency to well-known analogues, but surpass them in processing speed. An image is separated into binary images, and processing is carried out in parallel with each without an increase in speed, when increasing the number of bits on the image pixels. One more advantage of methods is the low consumption of energy resources. Only logical procedures are used and there are no computing operations. The methods can be useful in processing images of any class and assignment in processing systems with a limited time and energy resources.

Thinning spatial point processes into Poisson processes

DEFF Research Database (Denmark)

Møller, Jesper; Schoenberg, Frederic Paik

, and where one simulates backwards and forwards in order to obtain the thinned process. In the case of a Cox process, a simple independent thinning technique is proposed. In both cases, the thinning results in a Poisson process if and only if the true Papangelou conditional intensity is used, and thus can......This paper describes methods for randomly thinning certain classes of spatial point processes. In the case of a Markov point process, the proposed method involves a dependent thinning of a spatial birth-and-death process, where clans of ancestors associated with the original points are identified...... be used as a diagnostic for assessing the goodness-of-fit of a spatial point process model. Several examples, including clustered and inhibitive point processes, are considered....

Process validation for radiation processing

International Nuclear Information System (INIS)

Miller, A.

1999-01-01

Process validation concerns the establishment of the irradiation conditions that will lead to the desired changes of the irradiated product. Process validation therefore establishes the link between absorbed dose and the characteristics of the product, such as degree of crosslinking in a polyethylene tube, prolongation of shelf life of a food product, or degree of sterility of the medical device. Detailed international standards are written for the documentation of radiation sterilization, such as EN 552 and ISO 11137, and the steps of process validation that are described in these standards are discussed in this paper. They include material testing for the documentation of the correct functioning of the product, microbiological testing for selection of the minimum required dose and dose mapping for documentation of attainment of the required dose in all parts of the product. The process validation must be maintained by reviews and repeated measurements as necessary. This paper presents recommendations and guidance for the execution of these components of process validation. (author)

Thinning spatial point processes into Poisson processes

DEFF Research Database (Denmark)

Møller, Jesper; Schoenberg, Frederic Paik

2010-01-01

are identified, and where we simulate backwards and forwards in order to obtain the thinned process. In the case of a Cox process, a simple independent thinning technique is proposed. In both cases, the thinning results in a Poisson process if and only if the true Papangelou conditional intensity is used, and......In this paper we describe methods for randomly thinning certain classes of spatial point processes. In the case of a Markov point process, the proposed method involves a dependent thinning of a spatial birth-and-death process, where clans of ancestors associated with the original points......, thus, can be used as a graphical exploratory tool for inspecting the goodness-of-fit of a spatial point process model. Several examples, including clustered and inhibitive point processes, are considered....

Process correlation analysis model for process improvement identification.

Science.gov (United States)

Choi, Su-jin; Kim, Dae-Kyoo; Park, Sooyong

2014-01-01

Software process improvement aims at improving the development process of software systems. It is initiated by process assessment identifying strengths and weaknesses and based on the findings, improvement plans are developed. In general, a process reference model (e.g., CMMI) is used throughout the process of software process improvement as the base. CMMI defines a set of process areas involved in software development and what to be carried out in process areas in terms of goals and practices. Process areas and their elements (goals and practices) are often correlated due to the iterative nature of software development process. However, in the current practice, correlations of process elements are often overlooked in the development of an improvement plan, which diminishes the efficiency of the plan. This is mainly attributed to significant efforts and the lack of required expertise. In this paper, we present a process correlation analysis model that helps identify correlations of process elements from the results of process assessment. This model is defined based on CMMI and empirical data of improvement practices. We evaluate the model using industrial data.

Management of processes of electrochemical dimensional processing

Science.gov (United States)

Akhmetov, I. D.; Zakirova, A. R.; Sadykov, Z. B.

2017-09-01

In different industries a lot high-precision parts are produced from hard-processed scarce materials. Forming such details can only be acting during non-contact processing, or a minimum of effort, and doable by the use, for example, of electro-chemical processing. At the present stage of development of metal working processes are important management issues electrochemical machining and its automation. This article provides some indicators and factors of electrochemical machining process.

Chemical process engineering in the transuranium processing plant

International Nuclear Information System (INIS)

Collins, E.D.; Bigelow, J.E.

1976-01-01

Since operation of the Transuranium Processing Plant began, process changes have been made to counteract problems caused by equipment corrosion, to satisfy new processing requirements, and to utilize improved processes. The new processes, equipment, and techniques have been incorporated into a sequence of steps which satisfies all required processing functions

Dos projectes pedagògics: lectura extensiva i escriptura creativa en l'aula d'espanyol com a llengua estrangera

Directory of Open Access Journals (Sweden)

Victoria Rodrigo

2013-06-01

Full Text Available A través de la descripció de dues experiències docents realitzades en el context de l'ensenyament d'espanyol com a llengua estrangera, es revisa el paper de la lectura extensiva i la seua aplicació pedagògica en el saló de classe. El primer projecte -lectura extensiva i individual- serveix de base per al segon, la ‘creació de llibres’, on l'alumne comença sent lector i acaba convertint-se en autor, implementant-se una dinàmica de lectura-escriptura-lectura. El present treball és descriptiu i presenta el marc teòric que recolza cada projecte, pautes per a la seua execució i opinió dels participants.

The system of the measurement of reactor power and the monitoring of core power distribution

International Nuclear Information System (INIS)

Li Xianfeng

1999-01-01

The author mainly describes the measurement of the reactor power and the monitoring of the core power distribution in DAYA BAY nuclear power plant, introduces the calibration for the measurement system. Ex-core nuclear instrumentation system (RPN) and LOCA surveillance system (LSS) are the most important system for the object. they perform the measurement of the reactor power and the monitoring of the core power distribution on-line and timely. They also play the important roles in the reactor control and the reactor protection. For the same purpose there are test instrumentation system (KME) and in-core instrumentation system (RIC). All of them work together ensuring the exact measurement and effective monitoring, ensuring the safety of the reactor power plant

Operation of the NETL Chemical Looping Reactor with Natural Gas and a Novel Copper-Iron Material

Energy Technology Data Exchange (ETDEWEB)

Bayham, Sanuel [National Energy Technology Lab. (NETL), Morgantown, WV (United States); Straub, Doug [National Energy Technology Lab. (NETL), Morgantown, WV (United States); Weber, Justin [National Energy Technology Lab. (NETL), Morgantown, WV (United States)

2017-02-01

As part of the U.S. Department of Energy’s Advanced Combustion Program, the National Energy Technology Laboratory’s Research and Innovation Center (NETL R&IC) is investigating the feasibility of a novel combustion concept in which the GHG emissions can be significantly reduced. This concept involves burning fuel and air without mixing these two reactants. If this concept is technically feasible, then CO₂ emissions can be significantly reduced at a much lower cost than more conventional approaches. This indirect combustion concept has been called Chemical Looping Combustion (CLC) because an intermediate material (i.e., a metaloxide) is continuously cycled to oxidize the fuel. This CLC concept is the focus of this research and will be described in more detail in the following sections.

[Clarification on publications concerning the synthesis of acetylsalicylic acid].

Science.gov (United States)

Lafont, O

1996-01-01

Charles Frédéric Gerhardt (1816-1856) mentioned in his Traité de chimie Organique (1854) a publication, in French (realized in 1852 but published in 1853) entitled "Researches on anhydrous organic acids" in which, was reported the reaction of sodium salicylate with acetyl chloride. He thought that the reaction product was an acid anhydride, but obtained really crude acetylsalicylic acid. Later on, but also in 1853, a publication in german, by the same author related the same experiments. Surprisingly only the second publication has been mentioned in most of the historical studies on the subject. Acetyl salicylic acid was identified and synthesised in 1859 by von Gilm by another method and the product obtained by Gerhardt was identified to it in 1869.

FXYD5: Na+/ K+-ATPase Regulator in Health and Disease.

Directory of Open Access Journals (Sweden)

Irina eLubarski Gotliv

2016-03-01

Full Text Available FXYD5 (Dysadherin, RIC is a single span type I membrane protein that plays multiple roles in regulation of cellular functions. It is expressed in a variety of epithelial tissues and acts as an auxiliary subunit of the Na+/ K+-ATPase. During the past decade, a correlation between enhanced expression of FXYD5 and tumor progression has been established for various tumor types. In this review, current knowledge on FXYD5 is discussed, including experimental data on the functional effects of FXYD5 on the Na+/ K+-ATPase. FXYD5 modulates cellular junctions, influences chemokine production, and affects cell adhesion. The accumulated data may provide a basis for understanding the molecular mechanisms underlying FXYD5 mediated phenotypes.

Managing Process Variants in the Process Life Cycle

NARCIS (Netherlands)

Hallerbach, A.; Bauer, Th.; Reichert, M.U.

2007-01-01

When designing process-aware information systems, often variants of the same process have to be specified. Each variant then constitutes an adjustment of a particular process to specific requirements building the process context. Current Business Process Management (BPM) tools do not adequately

Nested Tracer Studies In Catchment Hydrology: Towards A Multiscale Understanding of Runoff Generation and Catchment Funtioning

Science.gov (United States)

Soulsby, C.; Rodgers, P.; Malcolm, I. A.; Dunn, S.

Geochemical and isotopic tracers have been shown to have widespread utility in catch- ment hydrology in terms of identifying hydrological source areas and characterising residence time distributions. In many cases application of tracer techniques has pro- vided insights into catchment functioning that could not be obtained from hydromet- ric and/or modelling studies alone. This paper will show how the use of tracers has contributed to an evolving perceptual model of hydrological pathways and runoff gen- eration processes in catchments in the Scottish highlands. In particular the paper will focus on the different insights that are gained at three different scales of analysis; (a) nested sub-catchments within a mesoscale (ca. 200 square kilometers) experimen- tal catchment; (b) hillslope-riparian interactions and (c) stream bed fluxes. Nested hydrometric and hydrochemical monitoring within the mesoscale Feugh catchment identified three main hydrological response units: (i) plateau peatlands which gener- ated saturation overland flow in the catchment headwaters, (ii) steep valley hillslopes which drain from the plateaux into (iii) alluvial and drift aquifers in the valley bottoms. End Member Mixing Analysis (EMMA) in 8 nested sub-catchments indicated that that stream water tracer concentrations can be modelled in terms of 2 dominant runoff pro- cesses; overland flow from the peat and groundwater from the drift aquifers. Ground- water contributions generally increased with catchment size, though this was moder- ated by the characteristics of individual sub-basins, with drift cover being particularly important. Hillslope riparian interactions were also examined using tracers, hydromet- ric data and a semi-distributed hydrological model. This revealed that in the glaciated, drift covered terrain of the Scottish highlands, extensive valley bottom aquifers effec- tively de-couple hillslope waters from the river channel. Thus, riparian groundwater appears to significantly

Applications of Process Synthesis: Moving from Conventional Chemical Processes towards Biorefinery Processes

DEFF Research Database (Denmark)

Yuan, Zhihong; Chen, Bingzhen; Gani, Rafiqul

2013-01-01

Concerns about diminishing petroleum reserves, enhanced worldwide demand for fuels and fluctuations in the global oil market, together with climate change and national security have promoted many initiatives for exploring alternative, non-petroleum based processes. Among these initiatives......, biorefinery processes for converting biomass-derived carbohydrates into transportation fuels and chemicals are now gaining more and more attention from both academia and industry. Process synthesis, which has played a vital role for the development, design and operation of (petro) chemical processes, can...

Visualizing the process of process modeling with PPMCharts

NARCIS (Netherlands)

Claes, J.; Vanderfeesten, I.T.P.; Pinggera, J.; Reijers, H.A.; Weber, B.; Poels, G.; La Rosa, M.; Soffer, P.

2013-01-01

In the quest for knowledge about how to make good process models, recent research focus is shifting from studying the quality of process models to studying the process of process modeling (often abbreviated as PPM) itself. This paper reports on our efforts to visualize this specific process in such

Process Intensification: A Perspective on Process Synthesis

DEFF Research Database (Denmark)

Lutze, Philip; Gani, Rafiqul; Woodley, John

2010-01-01

In recent years, process intensification (PI) has attracted considerable academic interest as a potential means for process improvement, to meet the increasing demands for sustainable production. A variety of intensified operations developed in academia and industry creates a large number...... of options to potentially improve the process but to identify the set of feasible solutions for PI in which the optimal can be found takes considerable resources. Hence, a process synthesis tool to achieve PI would potentially assist in the generation and evaluation of PI options. Currently, several process...... design tools with a clear focus on specific PI tasks exist. Therefore, in this paper, the concept of a general systematic framework for synthesis and design of PI options in hierarchical steps through analyzing an existing process, generating PI options in a superstructure and evaluating intensified...

Perceptual Processing Affects Conceptual Processing

Science.gov (United States)

van Dantzig, Saskia; Pecher, Diane; Zeelenberg, Rene; Barsalou, Lawrence W.

2008-01-01

According to the Perceptual Symbols Theory of cognition (Barsalou, 1999), modality-specific simulations underlie the representation of concepts. A strong prediction of this view is that perceptual processing affects conceptual processing. In this study, participants performed a perceptual detection task and a conceptual property-verification task…

A process insight repository supporting process optimization

OpenAIRE

Vetlugin, Andrey

2012-01-01

Existing solutions for analysis and optimization of manufacturing processes, such as online analysis processing or statistical calculations, have shortcomings that limit continuous process improvements. In particular, they lack means of storing and integrating the results of analysis. This makes the valuable information that can be used for process optimizations used only once and then disposed. The goal of the Advanced Manufacturing Analytics (AdMA) research project is to design an integrate...

Two-stage process analysis using the process-based performance measurement framework and business process simulation

NARCIS (Netherlands)

Han, K.H.; Kang, J.G.; Song, M.S.

2009-01-01

Many enterprises have recently been pursuing process innovation or improvement to attain their performance goals. To align a business process with enterprise performances, this study proposes a two-stage process analysis for process (re)design that combines the process-based performance measurement

Continuous Correctness of Business Processes Against Process Interference

NARCIS (Netherlands)

van Beest, Nick; Bucur, Doina

2013-01-01

In distributed business process support environments, process interference from multiple stakeholders may cause erroneous process outcomes. Existing solutions to detect and correct interference at runtime employ formal verification and the automatic generation of intervention processes at runtime.

Process mining: making knowledge discovery process centric

NARCIS (Netherlands)

Aalst, van der W.M.P.

2011-01-01

Recently, the Task Force on Process Mining released the Process Mining Manifesto. The manifesto is supported by 53 organizations and 77 process mining experts contributed to it. The active contributions from end-users, tool vendors, consultants, analysts, and researchers illustrate the growing

Business process model repositories : efficient process retrieval

NARCIS (Netherlands)

Yan, Z.

2012-01-01

As organizations increasingly work in process-oriented manner, the number of business process models that they develop and have to maintain increases. As a consequence, it has become common for organizations to have collections of hundreds or even thousands of business process models. When a

78 FR 46805 - Certain Transfers of Property to Regulated Investment Companies [RICs] and Real Estate Investment...

Science.gov (United States)

2013-08-02

... Property 1 has a fair market value of $500, PRS transfers Property 1 to X, a REIT, in exchange for stock of..., however, does not apply if the C corporation transferor makes a ``deemed sale election'' provided for... person at fair market value. The NPRM proposed to amend Sec. 1.337(d)-7 to provide two exceptions from...

77 FR 22516 - Certain Transfers of Property to Regulated Investment Companies [RICs] and Real Estate Investment...

Science.gov (United States)

2012-04-16

... the IRS believe that the inclusion of direct or indirect transfers by tax-exempt entities in the scope... regulations to provide that the definition of a C corporation excludes tax-exempt entities within the meaning... General Utilities doctrine in the Tax Reform Act of 1986 (Pub. L. 99-514, 100 Stat. 2085), as amended by...

Handlung, Text, Kultur. Überlegungen zur hermeneutischen Anthropologie zwischen Clifford Geertz und Paul Ricœur

Directory of Open Access Journals (Sweden)

Thiemo Breyer

2013-06-01

Full Text Available The paper investigates the phenomenon of foreignness and its understanding in ethnographic and philosophical context. The role of a phenomenologicalhermeneutic conception of text and action in bridging the gap between the native’s and the observer’s points of view with respect to the description of cultural phenomena is elucidated by way of comparing the theories of anthropologist Clifford Geertz and philosopher Paul Ricoeur. Hidden links between the two authors, who make sparse references to one another, but should be connected more thoroughly, are followed. The methods of “thick description” (Geertz and of taking the “text as a model” (Ricoeur for understanding social and cultural performances are analysed to attain a new notion of culture as context.

Aerodynamic isotope separation processes for uranium enrichment: process requirements

International Nuclear Information System (INIS)

Malling, G.F.; Von Halle, E.

1976-01-01

The pressing need for enriched uranium to fuel nuclear power reactors, requiring that as many as ten large uranium isotope separation plants be built during the next twenty years, has inspired an increase of interest in isotope separation processes for uranium enrichment. Aerodynamic isotope separation processes have been prominently mentioned along with the gas centrifuge process and the laser isotope separation methods as alternatives to the gaseous diffusion process, currently in use, for these future plants. Commonly included in the category of aerodynamic isotope separation processes are: (a) the separation nozzle process; (b) opposed gas jets; (c) the gas vortex; (d) the separation probes; (e) interacting molecular beams; (f) jet penetration processes; and (g) time of flight separation processes. A number of these aerodynamic isotope separation processes depend, as does the gas centrifuge process, on pressure diffusion associated with curved streamlines for the basic separation effect. Much can be deduced about the process characteristics and the economic potential of such processes from a simple and elementary process model. In particular, the benefit to be gained from a light carrier gas added to the uranium feed is clearly demonstrated. The model also illustrates the importance of transient effects in this class of processes

Business Process Innovation using the Process Innovation Laboratory

DEFF Research Database (Denmark)

Møller, Charles

for practical applications has not been identified. The aim of this paper is to establish a conceptual framework for business process innovation in the supply chain based on advanced enterprise systems. The main approach to business process innovation in this context is to create a new methodology for exploring...... process models and patterns of applications. The paper thus presents a new concept for business process innovation called the process innovation laboratory a.k.a. the ?-Lab. The ?-Lab is a comprehensive framework for BPI using advanced enterprise systems. The ?-Lab is a collaborative workspace...... for experimenting with process models and an explorative approach to study integrated modeling in a controlled environment. The ?-Lab facilitates innovation by using an integrated action learning approach to process modeling including contemporary technological, organizational and business perspectives....

Discovering Reference Process Models by Mining Process Variants

NARCIS (Netherlands)

Li, C.; Reichert, M.U.; Wombacher, Andreas

Recently, a new generation of adaptive Process-Aware Information Systems (PAIS) has emerged, which allows for dynamic process and service changes (e.g., to insert, delete, and move activities and service executions in a running process). This, in turn, has led to a large number of process variants

BUSINESS PROCESS REENGINEERING AS THE METHOD OF PROCESS MANAGEMENT

Directory of Open Access Journals (Sweden)

O. Honcharova

2013-09-01

Full Text Available The article is devoted to the analysis of process management approach. The main understanding of process management approach has been researched in the article. The definition of process and process management has been given. Also the methods of business process improvement has been analyzed, among them are fast-analysis solution technology (FAST, benchmarking, reprojecting and reengineering. The main results of using business process improvement have been described in figures of reducing cycle time, costs and errors. Also the tasks of business process reengineering have been noticed. The main stages of business process reengineering have been noticed. The main efficiency results of business process reengineering and its success factors have been determined.

Fundamentals of process intensification: A process systems engineering view

DEFF Research Database (Denmark)

Babi, Deenesh Kavi; Sales Cruz, Alfonso Mauricio; Gani, Rafiqul

2016-01-01

This chapter gives an overview of the fundamentals of process intensification from a process systems engineering point of view. The concept of process intensification, including process integration, is explained together with the drivers for applying process intensification, which can be achieved...

Idaho Chemical Processing Plant Process Efficiency improvements

International Nuclear Information System (INIS)

Griebenow, B.

1996-03-01

In response to decreasing funding levels available to support activities at the Idaho Chemical Processing Plant (ICPP) and a desire to be cost competitive, the Department of Energy Idaho Operations Office (DOE-ID) and Lockheed Idaho Technologies Company have increased their emphasis on cost-saving measures. The ICPP Effectiveness Improvement Initiative involves many activities to improve cost effectiveness and competitiveness. This report documents the methodology and results of one of those cost cutting measures, the Process Efficiency Improvement Activity. The Process Efficiency Improvement Activity performed a systematic review of major work processes at the ICPP to increase productivity and to identify nonvalue-added requirements. A two-phase approach was selected for the activity to allow for near-term implementation of relatively easy process modifications in the first phase while obtaining long-term continuous improvement in the second phase and beyond. Phase I of the initiative included a concentrated review of processes that had a high potential for cost savings with the intent of realizing savings in Fiscal Year 1996 (FY-96.) Phase II consists of implementing long-term strategies too complex for Phase I implementation and evaluation of processes not targeted for Phase I review. The Phase II effort is targeted for realizing cost savings in FY-97 and beyond

“Demeurer vivant jusqu’à...”: La question de la vie et de la mort et le “religieux commun” chez le dernier Ricœur

Directory of Open Access Journals (Sweden)

Yasuhiko Sugimura

2012-12-01

Full Text Available In spite of his clear and deliberate distinction between philosophical and religious discourse, Ricoeur lets these two aspects of his thought interweave with respect to the deep "conviction" motiving it. The idea of “attestation”, considered as the "password" granting access to his last "hermeneutics of the self", testifies to this in particular. This term, while containing a religious connotation, refers to what Heidegger calls Fundamentalontologie, in which attestation (Bezeugung is totally de-theologized to indicate how Dasein assumes its own death. But Ricoeur only incorporates this notion into his thought by making it undergo a profound modification. Ricoeur replaces “being–toward–death” with “remaining alive until…”, which allows him to recognize “the religious in common.” How can we develop a conception of the philosophy of religion from this winding process? This article marks a first step toward answering that question.

Process Accounting

OpenAIRE

Gilbertson, Keith

2002-01-01

Standard utilities can help you collect and interpret your Linux system's process accounting data. Describes the uses of process accounting, standard process accounting commands, and example code that makes use of process accounting utilities.

Modeling of biopharmaceutical processes. Part 2: Process chromatography unit operation

DEFF Research Database (Denmark)

Kaltenbrunner, Oliver; McCue, Justin; Engel, Philip

2008-01-01

Process modeling can be a useful tool to aid in process development, process optimization, and process scale-up. When modeling a chromatography process, one must first select the appropriate models that describe the mass transfer and adsorption that occurs within the porous adsorbent. The theoret......Process modeling can be a useful tool to aid in process development, process optimization, and process scale-up. When modeling a chromatography process, one must first select the appropriate models that describe the mass transfer and adsorption that occurs within the porous adsorbent...

Operation of the NETL Chemical Looping Reactor with Natural Gas and a Novel Copper-Iron Material

Energy Technology Data Exchange (ETDEWEB)

Straub, Douglas [National Energy Technology Lab. (NETL), Morgantown, WV (United States); Bayham, Samuel [National Energy Technology Lab. (NETL), Morgantown, WV (United States); Weber, Justin [National Energy Technology Lab. (NETL), Morgantown, WV (United States)

2017-02-21

The proposed Clean Power Plan requires CO₂ emission reductions of 30% by 2030 and further reductions are targeted by 2050. The current strategies to achieve the 30% reduction targets do not include options for coal. However, the 2016 Annual Energy Outlook suggests that coal will continue to provide more electricity than renewable sources for many regions of the country in 2035. Therefore, cost effective options to reduce greenhouse gas emissions from fossil fuel power plants are vital in order to achieve greenhouse gas reduction targets beyond 2030. As part of the U.S. Department of Energy’s Advanced Combustion Program, the National Energy Technology Laboratory’s Research and Innovation Center (NETL R&IC) is investigating the feasibility of a novel combustion concept in which the GHG emissions can be significantly reduced. This concept involves burning fuel and air without mixing these two reactants. If this concept is technically feasible, then CO₂ emissions can be significantly reduced at a much lower cost than more conventional approaches. This indirect combustion concept has been called Chemical Looping Combustion (CLC) because an intermediate material (i.e., a metal-oxide) is continuously cycled to oxidize the fuel. This CLC concept is the focus of this research and will be described in more detail in the following sections. The solid material that is used to transport oxygen is called an oxygen carrier material. The cost, durability, and performance of this material is a key issue for the CLC technology. Researchers at the NETL R&IC have developed an oxygen carrier material that consists of copper, iron, and alumina. This material has been tested extensively using lab scale instruments such as thermogravimetric analysis (TGA), scanning electron microscopy (SEM), mechanical attrition (ASTM D5757), and small fluidized bed reactor tests. This report will describe the results from a realistic, circulating, proof-of-concept test that was

Physics of intense, high energy radiation effects.

Energy Technology Data Exchange (ETDEWEB)

Hjalmarson, Harold Paul; Hartman, E. Frederick; Magyar, Rudolph J.; Crozier, Paul Stewart

2011-02-01

This document summarizes the work done in our three-year LDRD project titled 'Physics of Intense, High Energy Radiation Effects.' This LDRD is focused on electrical effects of ionizing radiation at high dose-rates. One major thrust throughout the project has been the radiation-induced conductivity (RIC) produced by the ionizing radiation. Another important consideration has been the electrical effect of dose-enhanced radiation. This transient effect can produce an electromagnetic pulse (EMP). The unifying theme of the project has been the dielectric function. This quantity contains much of the physics covered in this project. For example, the work on transient electrical effects in radiation-induced conductivity (RIC) has been a key focus for the work on the EMP effects. This physics in contained in the dielectric function, which can also be expressed as a conductivity. The transient defects created during a radiation event are also contained, in principle. The energy loss lead the hot electrons and holes is given by the stopping power of ionizing radiation. This information is given by the inverse dielectric function. Finally, the short time atomistic phenomena caused by ionizing radiation can also be considered to be contained within the dielectric function. During the LDRD, meetings about the work were held every week. These discussions involved theorists, experimentalists and engineers. These discussions branched out into the work done in other projects. For example, the work on EMP effects had influence on another project focused on such phenomena in gases. Furthermore, the physics of radiation detectors and radiation dosimeters was often discussed, and these discussions had impact on related projects. Some LDRD-related documents are now stored on a sharepoint site (https://sharepoint.sandia.gov/sites/LDRD-REMS/default.aspx). In the remainder of this document the work is described in catergories but there is much overlap between the atomistic

Ammonia volatilization from a paddy field following applications of urea: rice plants are both an absorber and an emitter for atmospheric ammonia.

Science.gov (United States)

Hayashi, Kentaro; Nishimura, Seiichi; Yagi, Kazuyuki

2008-02-15

Ammonia (NH(3)) volatilization from a paddy field following applications of urea was measured. Two lysimeters of Gray Lowland soil with a pH (H(2)O) of 5.7 were used for the experiment. Urea was applied at a rate of 50 kg N ha(-1) by incorporation as the basal fertilization (BF) and at rates of 30 and 10 kg N ha(-1) by top-dressing as the first (SF1) and second (SF2) supplemental fertilizations, respectively. Two wind tunnels per lysimeter were installed just after BF; one was transplanted with rice plants (PR plot), and the other was without rice plants (NR plot). Weak volatilization was observed at the PR plots after BF. By contrast, strong volatilization was observed at the PR plots after SF1 with a maximum flux of 150 g N ha(-1) h(-1); however, almost no volatilization was observed after SF2. The NH(3) volatilization loss accounted for 2.1%, 20.9%, 0.5%, and 8.2% of the applied urea at each application, BF, SF1, SF2, and the total application, respectively, for which only the net fluxes as volatilization were accumulated. The NH(3) volatilization fluxes from the paddy water surface (F(vol)) at the NR plots were estimated using a film model for its verification. After confirmation of good correlation, the film model was applied to estimate F(vol) at the PR plots. The NH(3) exchange fluxes by rice plants (F(ric)) were obtained by subtracting F(vol) from the observed net NH(3) flux. The derived F(ric) showed that the rice plants emitted NH(3) remarkably just after SF1 when a relatively high rate of urea was applied, although they absorbed atmospheric NH(3) in the other periods. In conclusion, rice plants are essentially an absorber of atmospheric NH(3); however, they turn into an emitter of NH(3) under excess nutrition of ammoniacal nitrogen.

Generalized Ornstein-Uhlenbeck processes and associated self-similar processes

CERN Document Server

Lim, S C

2003-01-01

We consider three types of generalized Ornstein-Uhlenbeck processes: the stationary process obtained from the Lamperti transformation of fractional Brownian motion, the process with stretched exponential covariance and the process obtained from the solution of the fractional Langevin equation. These stationary Gaussian processes have many common properties, such as the fact that their local covariances share a similar structure and they exhibit identical spectral densities at large frequency limit. In addition, the generalized Ornstein-Uhlenbeck processes can be shown to be local stationary representations of fractional Brownian motion. Two new self-similar Gaussian processes, in addition to fractional Brownian motion, are obtained by applying the (inverse) Lamperti transformation to the generalized Ornstein-Uhlenbeck processes. We study some of the properties of these self-similar processes such as the long-range dependence. We give a simulation of their sample paths based on numerical Karhunan-Loeve expansi...

Generalized Ornstein-Uhlenbeck processes and associated self-similar processes

International Nuclear Information System (INIS)

Lim, S C; Muniandy, S V

2003-01-01

We consider three types of generalized Ornstein-Uhlenbeck processes: the stationary process obtained from the Lamperti transformation of fractional Brownian motion, the process with stretched exponential covariance and the process obtained from the solution of the fractional Langevin equation. These stationary Gaussian processes have many common properties, such as the fact that their local covariances share a similar structure and they exhibit identical spectral densities at large frequency limit. In addition, the generalized Ornstein-Uhlenbeck processes can be shown to be local stationary representations of fractional Brownian motion. Two new self-similar Gaussian processes, in addition to fractional Brownian motion, are obtained by applying the (inverse) Lamperti transformation to the generalized Ornstein-Uhlenbeck processes. We study some of the properties of these self-similar processes such as the long-range dependence. We give a simulation of their sample paths based on numerical Karhunan-Loeve expansion

From Process Understanding to Process Control

NARCIS (Netherlands)

Streefland, M.

2010-01-01

A licensed pharmaceutical process is required to be executed within the validated ranges throughout the lifetime of product manufacturing. Changes to the process usually require the manufacturer to demonstrate that the safety and efficacy of the product remains unchanged. Recent changes in the

Integrated Process Modeling-A Process Validation Life Cycle Companion.

Science.gov (United States)

Zahel, Thomas; Hauer, Stefan; Mueller, Eric M; Murphy, Patrick; Abad, Sandra; Vasilieva, Elena; Maurer, Daniel; Brocard, Cécile; Reinisch, Daniela; Sagmeister, Patrick; Herwig, Christoph

2017-10-17

During the regulatory requested process validation of pharmaceutical manufacturing processes, companies aim to identify, control, and continuously monitor process variation and its impact on critical quality attributes (CQAs) of the final product. It is difficult to directly connect the impact of single process parameters (PPs) to final product CQAs, especially in biopharmaceutical process development and production, where multiple unit operations are stacked together and interact with each other. Therefore, we want to present the application of Monte Carlo (MC) simulation using an integrated process model (IPM) that enables estimation of process capability even in early stages of process validation. Once the IPM is established, its capability in risk and criticality assessment is furthermore demonstrated. IPMs can be used to enable holistic production control strategies that take interactions of process parameters of multiple unit operations into account. Moreover, IPMs can be trained with development data, refined with qualification runs, and maintained with routine manufacturing data which underlines the lifecycle concept. These applications will be shown by means of a process characterization study recently conducted at a world-leading contract manufacturing organization (CMO). The new IPM methodology therefore allows anticipation of out of specification (OOS) events, identify critical process parameters, and take risk-based decisions on counteractions that increase process robustness and decrease the likelihood of OOS events.

PC image processing

International Nuclear Information System (INIS)

Hwa, Mok Jin Il; Am, Ha Jeng Ung

1995-04-01

This book starts summary of digital image processing and personal computer, and classification of personal computer image processing system, digital image processing, development of personal computer and image processing, image processing system, basic method of image processing such as color image processing and video processing, software and interface, computer graphics, video image and video processing application cases on image processing like satellite image processing, color transformation of image processing in high speed and portrait work system.

Switzerland advances payments to CERN

CERN Multimedia

2002-01-01

In the picture, Charles Kleiber (third from left) visits the TI8 tunnel with (left to right) Jean-Luc Baldy, Head of the LHC civil engineering group, Luciano Maiani, CERN Director-General, Jean-Pierre Ruder, Swiss Delegate to CERN Council, Guy Hentsch, Personal adviser to the Director-General, Michel Buchs and Frédéric Chavan, representatives of the firm Prader Losinger. The State Secretary for Science and Research in Switzerland, Charles Kleiber, signed an agreement with CERN last week for an advancement of contributions from his country. The Confédération Helvétique will make an advanced payment of 90 million CHF. There will be no interest involved in this payment and the amount of money will be deducted from Switzerland's ordinary contributions to CERN in later years.

¿Es el escribir un diario un fármacon?

Directory of Open Access Journals (Sweden)

Luis Branda

2017-05-01

Full Text Available Resumen Tras un prolongado intercambio epistolar entre dos docentes universitarios (Branda, 2015; 2016, la relación afectuosa ha sido terminada por una de los correspondientes. En este escrito se presentan las entradas en el diario de Alberto, el otro correspondiente, donde se incluyen reflexiones relacionadas a Henri–Frédéric Amiel y referencias a los comentarios sobre su psicología que la lectura de su Journal intime ha generado en varios escritores, incluyendo Gregorio Marañón. También se menciona un aspecto de la vida de Amiel que parece haber recibido menos atención, que es su rol como docente. El diario finaliza con comentarios sobre las aspiraciones del diarista con reflexiones sobre el pasado y la incertidumbre del futuro.

Ceramic petrography, mineralogy and typology of Eneolithic pottery from Krašnja, Slovenia

Directory of Open Access Journals (Sweden)

Andreja Žibrat Gašparič

2014-12-01

Full Text Available In this article, we present newly excavated Eneolithic pottery from the site at Krašnja near Lukovica in central Slovenia. The material was AMS 14C dated and is contemporaneous with archaeological sites from the Ljubljansko barje region in Slovenia. The vessels were reconstructed and then various types of pots, dishes, cups, and beakers were analysed using petrography and the X-ray diffraction method. Additionally, the clay remains of walls and the floor of an Eneolithic kiln excavated at the site were also analysed. The results show that Eneolithic potters used different fab- rics to make vessels, and mostly one recipe with added calcite. The raw source material probably came from a nearby valley to the south of the site at Krašnja.

Georges et les secrets de l'univers

CERN Document Server

Hawking, Lucy; Galfard, Christophe; Parsons, Gary

2011-01-01

Un voyage ex-tra-or-di-naire dans l'Univers! Le jour où Georges rencontre ses nouveaux voisins, il est loin d'imaginer que sa vision du monde va être totalement bouleversée. Chez la jeune Annie et Éric, son scientifique de père, le garçon découvre Cosmos, l'ordinateur le plus perfectionné qui soit. Sa super intelligence permet de protéger Georges et ses amis aux quatre coins de l'Univers ! Hélas, quelqu'un nourrit de sombres projets... et quand on sait qu'il n y a rien de plus dangereux dans l'espace qu'un trou noir, il y a du souci à se faire ! Un roman essentiel sur l'Univers avec les découvertes de Stephen Hawking.

Dicty_cDB: Contig-U04201-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available ( CN212621 ) 26120 Suspension culture Solanum tuberosum cDNA, ... 58 6e-04 1 ( BU880962 ) UM57TA10 Populus flower cDNA library...m cD... 58 6e-08 2 ( EX067768 ) BR052412 pollen cDNA library KBPL Brassica rapa s... 48 8e-08 3 ( EX122995 ) BR106825 mature gre...2 ( EX137140 ) BR120970 root cDNA library KHRT Brassica rapa sub... 48 1e-07 3 ( EX124319 ) BR108149 matur...5', mRNA ... 48 2e-07 2 ( BU822514 ) UB38BPG02 Populus tremula cambium cDNA library Po... 58 4e-07 2 ( EX032...U359299_1( EU359299 |pid:none) Rickettsia helvetica isolate 73-3-... 171 3e-41 EU543436_1( EU543436 |pid:none) Uncultured Ric

Impact of environmental factors on biometric matching during human decomposition

Energy Technology Data Exchange (ETDEWEB)

Bolme, David S [ORNL; Tokola, Ryan A [ORNL; Boehnen, Chris Bensing [ORNL; Saul, Tiffany B [ORNL; Sauerwein, Kelly A [ORNL; Steadman, Dawnie W [ORNL

2016-01-01

Automatic recognition systems are a valuable tool for identifying unknown deceased individuals. Immediately af- ter death fingerprint and face biometric samples are easy to collect using standard sensors and cameras and can be easily matched to anti-mortem biometric samples. Even though post-mortem fingerprints and faces have been used for decades, there are no studies that track these biomet- rics through the later stages of decomposition to determine the length of time the biometrics remain viable. This paper discusses a multimodal dataset of fingerprints, faces, and irises from 14 human cadavers that decomposed outdoors under natural conditions. Results include predictive models relating time and temperature, measured as Accumulated Degree Days (ADD), and season (winter, spring, summer) to the predicted probably of automatic verification using a commercial algorithm.

L'autre feminine: De la passivité à l'action

Directory of Open Access Journals (Sweden)

Carlos A. Garduño Comparán

2013-05-01

Full Text Available Dans ce texte, la notion du féminin est explorée à travers deux schémas présents dans l'œuvre de Ricœur, celui de l'épopée et celui de la tragédie, symbolisés par les figures de Pénélope et Antigone. Par la suite, on proposera Médée comme un exemple qui s'adapte de manière appropriée à la problématique des études de genre, interprété par rapport aux développements de La Métaphore vive sur la ressemblance et la substitution, et au processus de la mimèsis dans Temps et récit.  

Meat Processing.

Science.gov (United States)

Legacy, Jim; And Others

This publication provides an introduction to meat processing for adult students in vocational and technical education programs. Organized in four chapters, the booklet provides a brief overview of the meat processing industry and the techniques of meat processing and butchering. The first chapter introduces the meat processing industry and…

Process for improving metal production in steelmaking processes

Science.gov (United States)

Pal, Uday B.; Gazula, Gopala K. M.; Hasham, Ali

1996-01-01

A process and apparatus for improving metal production in ironmaking and steelmaking processes is disclosed. The use of an inert metallic conductor in the slag containing crucible and the addition of a transition metal oxide to the slag are the disclosed process improvements.

Genetic Process Mining: Alignment-based Process Model Mutation

NARCIS (Netherlands)

Eck, van M.L.; Buijs, J.C.A.M.; Dongen, van B.F.; Fournier, F.; Mendling, J.

2015-01-01

The Evolutionary Tree Miner (ETM) is a genetic process discovery algorithm that enables the user to guide the discovery process based on preferences with respect to four process model quality dimensions: replay fitness, precision, generalization and simplicity. Traditionally, the ETM algorithm uses

Business process modeling for processing classified documents using RFID technology

Directory of Open Access Journals (Sweden)

Koszela Jarosław

2016-01-01

Full Text Available The article outlines the application of the processing approach to the functional description of the designed IT system supporting the operations of the secret office, which processes classified documents. The article describes the application of the method of incremental modeling of business processes according to the BPMN model to the description of the processes currently implemented (“as is” in a manual manner and target processes (“to be”, using the RFID technology for the purpose of their automation. Additionally, the examples of applying the method of structural and dynamic analysis of the processes (process simulation to verify their correctness and efficiency were presented. The extension of the process analysis method is a possibility of applying the warehouse of processes and process mining methods.

Novel process windows, part 1: Boosted micro process technology

NARCIS (Netherlands)

Hessel, V.; Wang, Q.

2011-01-01

Novel Process Windows (NPW) is the use of highly intensified, unusual and typically harsh process conditions to boost micro process technology and flow chemistry for the production of high-added value fine chemicals, pharmaceuticals, etc.. It is far from conventional processing and also from

Cognitive Processes in Discourse Comprehension: Passive Processes, Reader-Initiated Processes, and Evolving Mental Representations

Science.gov (United States)

van den Broek, Paul; Helder, Anne

2017-01-01

As readers move through a text, they engage in various types of processes that, if all goes well, result in a mental representation that captures their interpretation of the text. With each new text segment the reader engages in passive and, at times, reader-initiated processes. These processes are strongly influenced by the readers'…

Data processing

CERN Document Server

Fry, T F

2013-01-01

Data Processing discusses the principles, practices, and associated tools in data processing. The book is comprised of 17 chapters that are organized into three parts. The first part covers the characteristics, systems, and methods of data processing. Part 2 deals with the data processing practice; this part discusses the data input, output, and storage. The last part discusses topics related to systems and software in data processing, which include checks and controls, computer language and programs, and program elements and structures. The text will be useful to practitioners of computer-rel

In-process and post-process measurements of drill wear for control of the drilling process

Science.gov (United States)

Liu, Tien-I.; Liu, George; Gao, Zhiyu

2011-12-01

Optical inspection was used in this research for the post-process measurements of drill wear. A precision toolmakers" microscope was used. Indirect index, cutting force, is used for in-process drill wear measurements. Using in-process measurements to estimate the drill wear for control purpose can decrease the operation cost and enhance the product quality and safety. The challenge is to correlate the in-process cutting force measurements with the post-process optical inspection of drill wear. To find the most important feature, the energy principle was used in this research. It is necessary to select only the cutting force feature which shows the highest sensitivity to drill wear. The best feature selected is the peak of torque in the drilling process. Neuro-fuzzy systems were used for correlation purposes. The Adaptive-Network-Based Fuzzy Inference System (ANFIS) can construct fuzzy rules with membership functions to generate an input-output pair. A 1x6 ANFIS architecture with product of sigmoid membership functions can in-process measure the drill wear with an error as low as 0.15%. This is extremely important for control of the drilling process. Furthermore, the measurement of drill wear was performed under different drilling conditions. This shows that ANFIS has the capability of generalization.

Meeting report--Imaging the Cell.

Science.gov (United States)

Moreau, Violaine; Cordelières, Fabrice P; Poujol, Christel; Sagot, Isabelle; Saltel, Frédéric

2015-11-01

Every two years, the French Society for Cell Biology (SBCF) organises an international meeting called 'Imaging the Cell'. This year, the 8th edition was held on 24-26 June 2015 at University of Bordeaux Campus Victoire in the city of Bordeaux, France, a UNESCO World Heritage site. Over the course of three days, the meeting provided a forum for experts in different areas of cell imaging. Its unique approach was to combine conventional oral presentations during morning sessions with practical workshops at hosting institutes and the Bordeaux Imaging Center during the afternoons. The meeting, co-organised by Violaine Moreau and Frédéric Saltel (both INSERM U1053, Bordeaux, France), Christel Poujol and Fabrice Cordelières (both Bordeaux Imaging Center, Bordeaux, France) and Isabelle Sagot (Institut de Biochimie et Génétique Cellulaires, Bordeaux, France), brought together about 120 scientists including 16 outstanding speakers to discuss the latest advances in cell imaging. Thanks to recent progress in imaging technologies, cell biologists are now able to visualise, follow and manipulate cellular processes with unprecedented accuracy. The meeting sessions and workshops highlighted some of the most exciting developments in the field, with sessions dedicated to optogenetics, high-content screening, in vivo and live-cell imaging, correlative light and electron microscopy, as well as super-resolution imaging. © 2015. Published by The Company of Biologists Ltd.

Quasi-Birth-and-Death Processes with Rational Arrival Process Components

DEFF Research Database (Denmark)

Bean, Nigel G.; Nielsen, Bo Friis

to develop an analytic method for such a process, that parallels the analysis of a traditional QBD. We demonstrate the analysis by considering a queue where the arrival process and the sequence of service times are derived from two different RAPs that are not just Markovian Arrival processes. We also...... introduce an element of correlation between the arrival process and the sequence of service times.......In this paper we introduce the concept of a Quasi-Birth-and-Death process (QBD) with Rational Arrival Process components. We use the physical interpretation of a Rational Arrival Process (RAP), developed by Asmussen and Bladt, to consider such a Markov process. We exploit this interpretation...

Processes subject to integrated pollution control. Petroleum processes: oil refining and associated processes

International Nuclear Information System (INIS)

1995-01-01

This document, part of a series offering guidance on pollution control regulations issued by Her Majesty's Inspectorate of Pollution, (HMIP) focuses on petroleum processes such as oil refining and other associated processes. The various industrial processes used, their associated pollution release routes into the environment and techniques for controlling these releases are all discussed. Environmental quality standards are related to national and international agreements on pollution control and abatement. HMIP's work on air, water and land pollution monitoring is also reported. (UK)

Reflow process stabilization by chemical characteristics and process conditions

Science.gov (United States)

Kim, Myoung-Soo; Park, Jeong-Hyun; Kim, Hak-Joon; Kim, Il-Hyung; Jeon, Jae-Ha; Gil, Myung-Goon; Kim, Bong-Ho

2002-07-01

With the shrunken device rule below 130nm, the patterning of smaller contact hole with enough process margin is required for mass production. Therefore, shrinking technology using thermal reflow process has been applied for smaller contact hole formation. In this paper, we have investigated the effects of chemical characteristics such as molecular weight, blocking ratio of resin, cross-linker amount and solvent type with its composition to reflow process of resist and found the optimized chemical composition for reflow process applicable condition. And several process conditions like resist coating thickness and multi-step thermal reflow method have been also evaluated to stabilize the pattern profile and improve CD uniformity after reflow process. From the experiment results, it was confirmed that the effect of crosslinker in resist to reflow properties such as reflow temperature and reflow rate were very critical and it controlled the pattern profile during reflow processing. And also, it showed stable CD uniformity and improved resist properties for top loss, film shrinkage and etch selectivity. The application of lower coating thickness of resist induced symmetric pattern profile even at edge with wider process margin. The introduction of two-step baking method for reflow process showed uniform CD value, also. It is believed that the application of resist containing crosslinker and optimized process conditions for smaller contact hole patterning is necessary for the mass production with a design rule below 130nm.

Microcrystalline silicon deposition: Process stability and process control

International Nuclear Information System (INIS)

Donker, M.N. van den; Kilper, T.; Grunsky, D.; Rech, B.; Houben, L.; Kessels, W.M.M.; Sanden, M.C.M. van de

2007-01-01

Applying in situ process diagnostics, we identified several process drifts occurring in the parallel plate plasma deposition of microcrystalline silicon (μc-Si:H). These process drifts are powder formation (visible from diminishing dc-bias and changing spatial emission profile on a time scale of 10 0 s), transient SiH 4 depletion (visible from a decreasing SiH emission intensity on a time scale of 10 2 s), plasma heating (visible from an increasing substrate temperature on a time scale of 10 3 s) and a still puzzling long-term drift (visible from a decreasing SiH emission intensity on a time scale of 10 4 s). The effect of these drifts on the crystalline volume fraction in the deposited films is investigated by selected area electron diffraction and depth-profiled Raman spectroscopy. An example shows how the transient depletion and long-term drift can be prevented by suitable process control. Solar cells deposited using this process control show enhanced performance. Options for process control of plasma heating and powder formation are discussed

The permanent process

DEFF Research Database (Denmark)

Møller, Jesper; McCullagh, Peter

We extend the boson process first to a large class of Cox processes and second an even larger class of infinitely divisible point processes. Density and moment results are studied in detail. These results are obtained in closed form as weighted permanents, so the extension is called a permanent...... process. Temporal extensions and a particularly tractable case of the permanent process are also studied. Extensions of the ferminon process along similar lines, leading to so-called determinant processes, are discussed at the end. While the permanent process is attractive, the determinant process...

Multidimensional process discovery

NARCIS (Netherlands)

Ribeiro, J.T.S.

2013-01-01

Typically represented in event logs, business process data describe the execution of process events over time. Business process intelligence (BPI) techniques such as process mining can be applied to get strategic insight into business processes. Process discovery, conformance checking and

Process development

Energy Technology Data Exchange (ETDEWEB)

Schuegerl, K

1984-01-01

The item 'process development' comprises the production of acetonic/butonal with C. acetobylicum and the yeasting of potato waste. The target is to increase productivity by taking the following measures - optimation of media, on-line process analysis, analysis of reaction, mathematic modelling and identification of parameters, process simulation, development of a state estimator with the help of the on-line process analysis and the model, optimization and adaptive control.

Statistical Process Control for KSC Processing

Science.gov (United States)

Ford, Roger G.; Delgado, Hector; Tilley, Randy

1996-01-01

The 1996 Summer Faculty Fellowship Program and Kennedy Space Center (KSC) served as the basis for a research effort into statistical process control for KSC processing. The effort entailed several tasks and goals. The first was to develop a customized statistical process control (SPC) course for the Safety and Mission Assurance Trends Analysis Group. The actual teaching of this course took place over several weeks. In addition, an Internet version of the same course complete with animation and video excerpts from the course when it was taught at KSC was developed. The application of SPC to shuttle processing took up the rest of the summer research project. This effort entailed the evaluation of SPC use at KSC, both present and potential, due to the change in roles for NASA and the Single Flight Operations Contractor (SFOC). Individual consulting on SPC use was accomplished as well as an evaluation of SPC software for KSC use in the future. A final accomplishment of the orientation of the author to NASA changes, terminology, data format, and new NASA task definitions will allow future consultation when the needs arise.

A method for manufacturing a tool part for an injection molding process, a hot embossing process, a nano-imprint process, or an extrusion process

DEFF Research Database (Denmark)

2013-01-01

The present invention relates to a method for manufacturing a tool part for an injection molding process, a hot embossing process, nano-imprint process or an extrusion process. First, there is provided a master structure (10) with a surface area comprising nanometre-sized protrusions (11...

Process control using modern systems of information processing

International Nuclear Information System (INIS)

Baldeweg, F.

1984-01-01

Modern digital automation techniques allow the application of demanding types of process control. These types of process control are characterized by their belonging to higher levels in a multilevel model. Functional and technical aspects of the performance of digital automation plants are presented and explained. A modern automation system is described considering special procedures of process control (e.g. real time diagnosis)

DUAL-PROCESS, a highly reliable process control system

International Nuclear Information System (INIS)

Buerger, L.; Gossanyi, A.; Parkanyi, T.; Szabo, G.; Vegh, E.

1983-02-01

A multiprocessor process control system is described. During its development the reliability was the most important aspect because it is used in the computerized control of a 5 MW research reactor. DUAL-PROCESS is fully compatible with the earlier single processor control system PROCESS-24K. The paper deals in detail with the communication, synchronization, error detection and error recovery problems of the operating system. (author)

Quasi-Birth-and-Death Processes with Rational Arrival Process Components

DEFF Research Database (Denmark)

Bean, Nigel G.; Nielsen, Bo Friis

2010-01-01

This paper introduces the concept of a Quasi-Birth-and-Death process (QBD) with Rational Arrival Process (RAP) components. We use the physical interpretation of the prediction process of the RAP, developed by Asmussen and Bladt, and develop an analysis that parallels the analysis of a traditional...... QBD. Further, we present an algorithm for the numerical evaluation of the matrix G. As an example, we consider two queues where the arrival process and the sequence of service times are taken from two dependent RAPs, that are not Markovian Arrival Processes......This paper introduces the concept of a Quasi-Birth-and-Death process (QBD) with Rational Arrival Process (RAP) components. We use the physical interpretation of the prediction process of the RAP, developed by Asmussen and Bladt, and develop an analysis that parallels the analysis of a traditional...

Stochastic processes

CERN Document Server

Parzen, Emanuel

1962-01-01

Well-written and accessible, this classic introduction to stochastic processes and related mathematics is appropriate for advanced undergraduate students of mathematics with a knowledge of calculus and continuous probability theory. The treatment offers examples of the wide variety of empirical phenomena for which stochastic processes provide mathematical models, and it develops the methods of probability model-building.Chapter 1 presents precise definitions of the notions of a random variable and a stochastic process and introduces the Wiener and Poisson processes. Subsequent chapters examine