Challenges in the implementation of the EAACI AIT guidelines

DEFF Research Database (Denmark)

Ryan, D; Gerth van Wijk, R; Angier, E

2018-01-01

in 32% of countries. Additionally, 44% of respondents considered accessibility to AIT and 36% stating patient costs were barriers. CONCLUSIONS: Successful working with primary care providers is essential to scaling-up AIT provision in Europe, but to achieve this the identified barriers must be overcome...

Curcuma aromatica Water Extract Attenuates Ethanol-Induced Gastritis via Enhancement of Antioxidant Status

Directory of Open Access Journals (Sweden)

Woo-Young Jeon

2015-01-01

Full Text Available Curcuma aromatica is an herbal medicine and traditionally used for the treatment of various diseases in Asia. We investigated the effects of C. aromatica water extract (CAW in the stomach of rats with ethanol-induced gastritis. Gastritis was induced in rats by intragastric administration of 5 mL/kg body weight of absolute ethanol. The CAW groups were given 250 or 500 mg of extract/kg 2 h before administration of ethanol, respectively. To determine the antioxidant effects of CAW, we determined the level of lipid peroxidation, the level of reduced glutathione (GSH, the activities of catalase, degree of inflammation, and mucus production in the stomach. CAW reduced ethanol-induced inflammation and loss of epithelial cells and increased the mucus production in the stomach. CAW reduced the increase in lipid peroxidation associated with ethanol-induced gastritis (250 and 500 mg/kg, p<0.01, resp. and increased mucosal GSH content (500 mg/kg, p<0.01 and the activity of catalase (250 and 500 mg/kg, p<0.01, resp.. CAW increased the production of prostaglandin E2. These findings suggest that CAW protects against ethanol-induced gastric mucosa injury by increasing antioxidant status. We suggest that CAW could be developed for the treatment of gastritis induced by alcohol.

Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation

Energy Technology Data Exchange (ETDEWEB)

Salinero, Kennan Kellaris; Keller, Keith; Feil, William S.; Feil, Helene; Trong, Stephan; Di Bartolo, Genevieve; Lapidus, Alla

2008-11-17

Initial interest in Dechloromonas aromatica strain RCB arose from its ability to anaerobically degrade benzene. It is also able to reduce perchlorate and oxidize chlorobenzoate, toluene, and xylene, creating interest in using this organism for bioremediation. Little physiological data has been published for this microbe. It is considered to be a free-living organism. The a priori prediction that the D. aromatica genome would contain previously characterized 'central' enzymes involved in anaerobic aromatic degradation proved to be false, suggesting the presence of novel anaerobic aromatic degradation pathways in this species. These missing pathways include the benzyl succinyl synthase (bssABC) genes (responsible for formate addition to toluene) and the central benzoylCoA pathway for monoaromatics. In depth analyses using existing TIGRfam, COG, and InterPro models, and the creation of de novo HMM models, indicate a highly complex lifestyle with a large number of environmental sensors and signaling pathways, including a relatively large number of GGDEF domain signal receptors and multiple quorum sensors. A number of proteins indicate interactions with an as yet unknown host, as indicated by the presence of predicted cell host remodeling enzymes, effector enzymes, hemolysin-like proteins, adhesins, NO reductase, and both type III and type VI secretory complexes. Evidence of biofilm formation including a proposed exopolysaccharide complex with the somewhat rare exosortase (epsH), is also present. Annotation described in this paper also reveals evidence for several metabolic pathways that have yet to be observed experimentally, including a sulphur oxidation (soxFCDYZAXB) gene cluster, Calvin cycle enzymes, and nitrogen fixation (including RubisCo, ribulose-phosphate 3-epimerase, and nif gene families, respectively). Analysis of the D. aromatica genome indicates there is much to be learned regarding the metabolic capabilities, and life-style, for this microbial

Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation

Directory of Open Access Journals (Sweden)

Feil Helene

2009-08-01

Full Text Available Abstract Background Initial interest in Dechloromonas aromatica strain RCB arose from its ability to anaerobically degrade benzene. It is also able to reduce perchlorate and oxidize chlorobenzoate, toluene, and xylene, creating interest in using this organism for bioremediation. Little physiological data has been published for this microbe. It is considered to be a free-living organism. Results The a priori prediction that the D. aromatica genome would contain previously characterized "central" enzymes to support anaerobic aromatic degradation of benzene proved to be false, suggesting the presence of novel anaerobic aromatic degradation pathways in this species. These missing pathways include the benzylsuccinate synthase (bssABC genes (responsible for fumarate addition to toluene and the central benzoyl-CoA pathway for monoaromatics. In depth analyses using existing TIGRfam, COG, and InterPro models, and the creation of de novo HMM models, indicate a highly complex lifestyle with a large number of environmental sensors and signaling pathways, including a relatively large number of GGDEF domain signal receptors and multiple quorum sensors. A number of proteins indicate interactions with an as yet unknown host, as indicated by the presence of predicted cell host remodeling enzymes, effector enzymes, hemolysin-like proteins, adhesins, NO reductase, and both type III and type VI secretory complexes. Evidence of biofilm formation including a proposed exopolysaccharide complex and exosortase (epsH are also present. Annotation described in this paper also reveals evidence for several metabolic pathways that have yet to be observed experimentally, including a sulphur oxidation (soxFCDYZAXB gene cluster, Calvin cycle enzymes, and proteins involved in nitrogen fixation in other species (including RubisCo, ribulose-phosphate 3-epimerase, and nif gene families, respectively. Conclusion Analysis of the D. aromatica genome indicates there is much to be

Teenuse ait-kuivati vajab kiiret tegutsemist / Maire Kõrver

Index Scriptorium Estoniae

Kõrver, Maire, 1961-

2009-01-01

Märjamaa vallale kuuluva arhitektuurimälestsena kaitse all oleva Teenuse mõisa ait-kuivati renoveerimise seisust. Hoone sai uued katuse aluskonstruktsioonid, kuid on katuseta. Taastamine on takerdunud seoses projektide rahastamisega

Effect of Massoia (Massoia aromatica Becc.) Bark on the Phagocytic Activity of Wistar Rat Macrophages

OpenAIRE

Triana Hertiani; Agustinus Yuswanto; Sylvia Utami Tunjung Pratiwi; Harlyanti Muthma’innah Mashar

2018-01-01

The essential oil of Massoia (Massoia aromatica Becc., Lauraceae) bark is a potential immunomodulator in vitro. This study evaluated the potential immunomodulatory effects of Massoia bark infusion on the nonspecific immune response (phagocytosis) of Wistar rats. For the in vitro assay, macrophages were treated with the freeze-dried infusion at the concentrations of 2.5, 5, 10, 20, or 40 µg/mL media. For the in vivo assay, two-month-old male Wistar rats were divided into five groups. The...

Tamazight Basic Course: Ait Mgild Dialect.

Science.gov (United States)

Harries, Jeanette

The materials for this course in the Ait Mgild dialect of Tamazight, one of the three main languages into which the Berber dialects of Morocco are grouped, include this textbook, 32 tape recordings, and 260 colored slides keyed to the lessons. Lesson material on each tape does not exceed 26 minutes. The remaining four to eight minutes of the tape…

X-ray radiography inspection of core model of the CODEX AIT-2 facility

International Nuclear Information System (INIS)

Balasko, M.; Hozer, Z.; Maroti, L.; Windberg, P

1999-01-01

X-ray radiography is an advanced non-destructive technique to visualize and analyze the different damages of the investigated objects. An oxidation phenomena in severe accident was simulated by the CODEX AIT-2 test facility. The placement, the extension and features of the damages were discovered by radioscopy and film technique before cutting into slices the AIT-2 boundle. (author)

Reversal of cycloheximide-induced memory disruption by AIT-082 (Neotrofin) is modulated by, but not dependent on, adrenal hormones.

Science.gov (United States)

Yan, Rongzi; Nguyen, Quang; Gonzaga, James; Johnson, Mai; Ritzmann, Ronald F; Taylor, Eve M

2003-04-01

AIT-082 (Neotrofin), a hypoxanthine derivative, has been shown to improve memory in both animals and humans. In animals, adrenal hormones modulate the efficacy of many memory-enhancing compounds, including piracetam and tacrine (Cognex). To investigate the role of adrenal hormones in the memory-enhancing action of AIT-082. Plasma levels of adrenal hormones (corticosterone and aldosterone) in mice were significantly reduced by surgical or chemical (aminoglutethimide) adrenalectomy or significantly elevated by oral administration of corticosterone. The effects of these hormone level manipulations on the memory-enhancing activity of AIT-082 and piracetam were evaluated using a cycloheximide-induced amnesia/passive avoidance model. As previously reported by others, the memory enhancing action of piracetam was abolished by adrenalectomy. In contrast, the memory enhancement by 60 mg/kg AIT-082 (IP) was unaffected. However, a sub-threshold dose of AIT-082 (0.1 mg/kg, IP) that did not improve memory in control animals did improve memory in adrenalectomized animals. These data suggested that, similar to piracetam and tacrine, the memory enhancing action of AIT-082 might be inhibited by high levels of adrenal hormones. As expected, corticosterone (30 and 100 mg/kg) inhibited the action of piracetam, however no dose up to 100 mg/kg corticosterone inhibited the activity of AIT-082. These data suggest that while AIT-082 function is not dependent on adrenal hormones, it is modulated by them. That memory enhancement by AIT-082 was not inhibited by high plasma corticosterone levels may have positive implications for its clinical utility, given that many Alzheimer's disease patients have elevated plasma cortisol levels.

Cytological evidences of pollen abortion in Ornithogalum caudatum Ait

African Journals Online (AJOL)

Administrator

2011-10-19

Oct 19, 2011 ... sterility. INTRODUCTION. Genus Ornithogalum caudatum Ait, with common name ..... chromosome association in F1 hybrids Triticum aestivum × Secale ... nutrient metabolism and pollen abortion of male sterile lines in Lycium.

Galileo - The Serial-Production AIT Challenge

Science.gov (United States)

Ragnit, Ulrike; Brunner, Otto

2008-01-01

The Galileo Project is one of the most demanding projects of ESA, being Europe's autarkic navigation system and a constellation composed of 30 satellites. This presentation points out the different phases of the project up to the full operational capability and the corresponding launch options with respect to launch vehicles as well as launch configurations. One of the biggest challenges is to set up a small serial 'production line' for the overall integration and test campaign of satellites. This production line demands an optimization of all relevant tasks, taking into account also backup and recovery actions. A comprehensive AIT concept is required, reflecting a tightly merged facility layout and work flow design. In addition a common data management system is needed to handle all spacecraft related documentation and to have a direct input-out flow for all activities, phases and positions at the same time. Process optimization is a well known field of engineering in all small high tech production lines, nevertheless serial production of satellites are still not the daily task in space business and therefore new concepts have to be put in place. Therefore, and in order to meet the satellites overall system optimization, a thorough interface between unit/subsystem manufacturing and satellite AIT must be realized to ensure a smooth flow and to avoid any process interruption, which would directly lead to a schedule impact.

Biochemical modifications in Pinus pinaster Ait. as a result of environmental pollution.

Science.gov (United States)

Acquaviva, Rosaria; Vanella, Luca; Sorrenti, Valeria; Santangelo, Rosa; Iauk, Liliana; Russo, Alessandra; Savoca, Francesca; Barbagallo, Ignazio; Di Giacomo, Claudia

2012-11-01

Exposure to chemical pollution can cause significant damage to plants by imposing conditions of oxidative stress. Plants combat oxidative stress by inducing antioxidant metabolites, enzymatic scavengers of activated oxygen and heat shock proteins. The accumulation of these proteins, in particular heat shock protein 70 and heme oxygenase, is correlated with the acquisition of thermal and chemical adaptations and protection against oxidative stress. In this study, we used Pinus pinaster Ait. collected in the areas of Priolo and Aci Castello representing sites with elevated pollution and reference conditions, respectively. The presence of heavy metals and the levels of markers of oxidative stress (lipid hydroperoxide levels, thiol groups, superoxide dismutase activity and expression of heat shock protein 70, heme oxygenase and superoxide dismutase) were evaluated, and we measured in field-collected needles the response to environmental pollution. P. pinaster Ait. collected from a site characterized by industrial pollution including heavy metals had elevated stress response as indicated by significantly elevated lipid hydroperoxide levels and decreased thiol groups. In particular, we observed that following a chronic chemical exposure, P. pinaster Ait. showed significantly increased expression of heat shock protein 70, heme oxygenase and superoxide dismutase. This increased expression may have protective effects against oxidative stress and represents an adaptative cellular defence mechanism. These results suggest that evaluation of heme oxygenase, heat shock protein 70 and superoxide dismutase expression in P. pinaster Ait. could represent a useful tool for monitoring environmental contamination of a region and to better understand mechanisms involved in plant defence and stress tolerance.

Parameterization of surface irradiance and primary production in Århus Bay, SW Kattegat, Baltic Sea

DEFF Research Database (Denmark)

Lund-Hansen, Lars Chresten; Sørensen, Helene Munk

2009-01-01

. The study is based on a one year long time-series of PAR, CTD-casts (n = 45), and primary production measurements (n = 24) from Århus Bay (56°09′ N; 10°20′ E), south west Kattegat. Results showed a high and positive correlation between observed and calculated primary production in the bay, as based...

Advanced Interface for Tactical Security (AITS) Problem Analysis and Concept Definition

National Research Council Canada - National Science Library

Murray, S

1999-01-01

The Advanced Interface for Tactical Security (AITS) project was initiated to improve the task performance of security forces through technology and design improvements to information display systems...

Color improvement by irradiation of Curcuma aromatica extract for industrial application

International Nuclear Information System (INIS)

Kim, Jae Kyung; Jo, Cheorun; Hwang, Han Joon; Park, Hyun Jin; Kim, Young Ji; Byun, Myung Woo

2006-01-01

Curcuma species are medicinal herbs with various pharmacological activities. They have a characteristic yellow color and contain curcuminoids which are natural antioxidants. In this study, Curcuma aromatica (Canada) and Curcuma longa (CL) extracts were gamma-irradiated for improving the color, and the irradiation effects on the curcuminoids contents in CA and CL extracts were determined in order to evaluate if CA can replace CL on the market, where the price of CA is 70% lower than the price of CL. The Hunter color L*-values were increased significantly in all the samples with increasing dose, while the a*-values and b*-values decreased, which implies that the color of the CA and CL extracts changed from dark yellow to brighter yellow. Curcuminoids contents of all the samples were evaluated, and CA contains more curcuminoids than CL. These results indicated that irradiation improved the properties of CA for possible industrial use in manufacturing food and cosmetic industrial products

Color improvement by irradiation of Curcuma aromatica extract for industrial application

Energy Technology Data Exchange (ETDEWEB)

Kim, Jae Kyung [Radiation Food Science and Biotechnology Team, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup 580-185 (Korea, Republic of); Jo, Cheorun [Radiation Food Science and Biotechnology Team, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup 580-185 (Korea, Republic of); Hwang, Han Joon [Graduate School of Biotechnology, Korea University, 5-1, Anam-dong, Sungbuk-Gu, Seoul 136-701 (Korea, Republic of); Park, Hyun Jin [Graduate School of Biotechnology, Korea University, 5-1, Anam-dong, Sungbuk-Gu, Seoul 136-701 (Korea, Republic of); Kim, Young Ji [Division of Food Beverage and Culinary Arts, Younganm College of Science and Technology, Daegu 705-703 (Korea, Republic of); Byun, Myung Woo [Radiation Food Science and Biotechnology Team, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup 580-185 (Korea, Republic of)]. E-mail: mwbyun@kaeri.re.kr

2006-03-15

Curcuma species are medicinal herbs with various pharmacological activities. They have a characteristic yellow color and contain curcuminoids which are natural antioxidants. In this study, Curcuma aromatica (Canada) and Curcuma longa (CL) extracts were gamma-irradiated for improving the color, and the irradiation effects on the curcuminoids contents in CA and CL extracts were determined in order to evaluate if CA can replace CL on the market, where the price of CA is 70% lower than the price of CL. The Hunter color L*-values were increased significantly in all the samples with increasing dose, while the a*-values and b*-values decreased, which implies that the color of the CA and CL extracts changed from dark yellow to brighter yellow. Curcuminoids contents of all the samples were evaluated, and CA contains more curcuminoids than CL. These results indicated that irradiation improved the properties of CA for possible industrial use in manufacturing food and cosmetic industrial products.

Color improvement by irradiation of Curcuma aromatica extract for industrial application

Science.gov (United States)

Kim, Jae Kyung; Jo, Cheorun; Hwang, Han Joon; Park, Hyun Jin; Kim, Young Ji; Byun, Myung Woo

2006-03-01

Curcuma species are medicinal herbs with various pharmacological activities. They have a characteristic yellow color and contain curcuminoids which are natural antioxidants. In this study, Curcuma aromatica (CA) and Curcuma longa (CL) extracts were gamma-irradiated for improving the color, and the irradiation effects on the curcuminoids contents in CA and CL extracts were determined in order to evaluate if CA can replace CL on the market, where the price of CA is 70% lower than the price of CL. The Hunter color L*-values were increased significantly in all the samples with increasing dose, while the a*-values and b*-values decreased, which implies that the color of the CA and CL extracts changed from dark yellow to brighter yellow. Curcuminoids contents of all the samples were evaluated, and CA contains more curcuminoids than CL. These results indicated that irradiation improved the properties of CA for possible industrial use in manufacturing food and cosmetic industrial products.

Cytological evidences of pollen abortion in Ornithogalum caudatum Ait

African Journals Online (AJOL)

Administrator

2011-10-19

Oct 19, 2011 ... Ornithogalum caudatum Ait exhibits strong physiological adaptability; however, it suffers a serious menace of pollen abortion, as almost no seed is formed in the plants. In the current study, chromosome karyotype of root-tip cells (RTC) during mitosis, and chromosome behavior of pollen mother cells.

Evaluating the Antimicrobial Activity of Methonolic Extract of Rhus Succedanea Leaf Gall

Directory of Open Access Journals (Sweden)

Savitri Shrestha

2013-12-01

Full Text Available Introduction: The worldwide increased bacterial resistance to antibiotics and the undesirable side effects associated with constant use of synthetic drugs has prompted the search for novel antimicrobial agents, particularly those manufactured from plants. This study is designed to ascertain the antibacterial potential of Rhus succedanea leaf gall extracts on the growth of gram-positive and gram–negative bacteria. Methods: The methanolic and hexane extract of different concentrations (100, 250, and 500 μg/ml were prepared and their antibacterial efficacy was tested against clinical isolates of Escherichia coli, Salmonella typhi, Micrococcus luteus, and Staphylococcus aureus using agar well diffusion method and the size of inhibition zone was measured in millimeters. Results: The methanol and hexane extracts differed significantly in their antimicrobial activity with methanol extract showing a potent inhibitory activity in the range of 16±2 to 23±1, which was almost equal to the values of ciprofloxacin (25±3, used as a standard. Further, the methanol extract was mostly potent and effective in inhibiting the growth of gram-negative bacteria, namely, E. coli, when compared to gram –positive bacteria stains, which are responsible for antimicrobial activities. The phytochemical screening showed positive results for the presence of steroids, triterpenes, alkaloids, and carbohydrates. Conclusion: The potent antibacterial activity of Rhus succedanea leaf gall extracts indicates its useful therapeutic application against bacterial infection. Furthermore, this study indicates that the extract might be exploited as natural drug for the treatment of infectious diseases and could be useful in understanding the relations between traditional cures and current medications.

Loits skandaalitses gaalal. Sparks Rabarockil. Pärimusmuusika Ait

Index Scriptorium Estoniae

2008-01-01

Pärnu Kontserdimajas Eesti muusikaauhindade galal üle astunud rockansambel Loits röövis koostöös kultuskirjaniku Sven Kivisildnikuga aasta metal/punk-artisti auhinna, mis pidi minema industrial-metal-artistile Finish Me Off. Ameerika bänd Sparks 14. juunil Järvakandis Rabarockil. Viljandis Tasuja pst.6 avati Eesti Pärimusmuusika Keskuse uus kodu - Pärimusmuusika Ait

Size-Controlled Production of Gold Bionanoparticles Using the Extremely Acidophilic Fe(III-Reducing Bacterium, Acidocella aromatica

Directory of Open Access Journals (Sweden)

Intan Nurul Rizki

2018-02-01

Full Text Available Recycling of gold-bearing “urban mine” resources, such as waste printed circuit boards (PCBs, is attracting an increasing interest. Some of the gold leaching techniques utilize acidic lixiviants and in order to eventually target such acidic leachates, the utility of the acidophilic Fe(III-reducing heterotrophic bacterium, Acidocella (Ac. aromatica PFBC was evaluated for production of Au(0 bionanoparticles (bio-AuNPs. Au(III ions (as AuCl4−, initially 10 mg/L, were readily adsorbed onto the slightly-positively charged Ac. aromatica cell surface and transported into cytoplasm to successfully form intracellular bio-AuNPs in a simple one-step microbiological reaction. Generally, increasing the initial concentration of formate as e-donor corresponded to faster Au(III bioreduction and a greater number of Au(0 nucleation sites with less crystal growth within 40–60 h: i.e., use of 1, 5, 10, or 20 mM formate led to production of bio-AuNPs of 48, 24, 13, or 12 nm in mean particle size with 2.3, 17, 62, and 97 particles/cell, respectively. Addition of Cu2+ as an enzymatic inhibitor significantly decreased the number of Au(0 nucleation sites but enhanced crystal growth of individual particles. As a result, the manipulation of the e-donor concentration combined with an enzyme inhibitor enabled the 3-grade size-control of bio-AuNPs (nearly within a normal distribution at 48, 26 or 13 nm by use of 1 mM formate, 20 mM formate (+Cu2+ or 10 mM formate, respectively, from highly acidic, dilute Au(III solutions.

Cytological evidences of pollen abortion in Ornithogalum caudatum Ait

African Journals Online (AJOL)

Ornithogalum caudatum Ait exhibits strong physiological adaptability; however, it suffers a serious menace of pollen abortion, as almost no seed is formed in the plants. In the current study, chromosome karyotype of root-tip cells (RTC) during mitosis, and chromosome behavior of pollen mother cells (PMC) during meiosis in ...

Down-Regulation of Glycosyl Transferase Genes in Streptococcus Mutans by Punica Granatum L. Flower and Rhus Coriaria L. Fruit Water Extracts.

Science.gov (United States)

Vahid-Dastjerdi, Elahe; Monadi, Elham; Khalighi, Hamid Reza; Torshabi, Maryam

2016-01-01

In our previous studies, we showed the inhibitory effects of Punica granatum L. flower and Rhus coriaria L. fruit water extracts on dental plaque accumulation by several bacteria, especially Streptococcus mutans (S. mutans), on orthodontic wire by in-vitro assays. In this study, the anti-cariogenic properties of the extracts were evaluated by assessing their effects on expression of glycosyltransferase (gtf) genes, which are responsible for initial biofilm formation by S. mutans. In this study, the effect of herbal extracts on expression of gtfB, C (encoding enzymes that produce water-insoluble glucans) and D (encoding enzymes that produce water-soluble glucans) genes in S. mutans growing in planktonic state was evaluated quantitatively by real-time polymerase chain reaction (PCR) method. The minimum biofilm inhibitory concentration (MBIC) of understudied herbal water extracts significantly suppressed gtfB, C and D gene expression by 85.3 ± 7.5%, 33.3 ± 6.4% and 25 ± 14%, respectively for Punica granatum L. extract and 73.4 ± 7.3%, 93.8 ± 2.7% and 59.3 ± 9.8%, respectively for Rhus coriaria L. extract compared to the non-treated control group (P Punica granatum L. extract. These findings suggest that Punica granatum L. and especially Rhus coriaria L. maybe used as novel, natural antiplaque agents since they inhibit specific genes associated with bacterial biofilm formation without necessarily affecting the growth of oral bacteria.

¿Sirve la escala ABCD2 del AIT para predecir y prevenir Ictus?

Directory of Open Access Journals (Sweden)

Laura Castelo Corral

2015-09-01

Resultados: Incluimos 172 pacientes ( edad media 71 años, 51% mujeres con un nuevo diagnostico de AIT. La puntuación media de la escala ABCD2 fue de 4.2 ± 1.4. Se produjeron 12 nuevos AIT, 21 Ictus no fatales y 3 ictus fatales durante el seguimiento. La mortalidad intrahospitalaria fue del 1.7% y la total durante el seguimiento de 1 año del 12 %. Una puntuación en la escala de ABCD2 de ≥ 4 tenia una sensibilidad del 88% y del 82% para predecir un ictus a los 7 y 30 días respectivamente, con una pobre especificidad del 30%.El valor predictivo negativo a 7 dias fue del 98%. Una puntuación ABCD2 ≥ 4 no tuvo valor predictivo significativo de ictus a los 7 días (hazard ratio [HR], 3.49; 95%CI, 0.42 to 27.93 ni a 30 días (HR, 1.97; 95%CI, 0.43 to 9.13. Como componente individual, solo la diabetes predijo la probabilidad de desarrollar un ictus en la primera semana (HR, 5.47; 95%IC 1.43 to 20.95 y durante el primer mes (HR, 3.60; 95%IC 1.08 to 12. Conclusiones: El poder discriminativo de la escala ABCD2 no ayuda a tomar decisiones de tratamiento salvo por su valor predictivo negativo del 98%. Solo la variable diabetes de la escala se asocio con una probabilidad relevante de tener un ictus.Probablemente cualquier tipo de presentación de AIT justifica la búsqueda rápida de la etiologia subyacente. Consideramos que en el AIT, independientemente de la escala ABCD2 , se debe realizar en menos de 24 horas un TAC cerebral, ECG, e imagen de carótida, mientras al mismo tiempo se inicia tratamiento preventivo urgente.

Rhus javanica Gall Extract Inhibits the Differentiation of Bone Marrow-Derived Osteoclasts and Ovariectomy-Induced Bone Loss

Directory of Open Access Journals (Sweden)

Tae-Ho Kim

2016-01-01

Full Text Available Inhibition of osteoclast differentiation and bone resorption is a therapeutic strategy for the management of postmenopausal bone loss. This study investigated the effects of Rhus javanica (R. javanica extracts on bone marrow cultures to develop agents from natural sources that may prevent osteoclastogenesis. Extracts of R. javanica (eGr cocoons spun by Rhus javanica (Bell. Baker inhibited the osteoclast differentiation and bone resorption. The effects of aqueous extract (aeGr or 100% ethanolic extract (eeGr on ovariectomy- (OVX- induced bone loss were investigated by various biochemical assays. Furthermore, microcomputed tomography (µCT was performed to study bone remodeling. Oral administration of eGr (30 mg or 100 mg/kg/day for 6 weeks augmented the inhibition of femoral bone mineral density (BMD, bone mineral content (BMC, and other factors involved in bone remodeling when compared to OVX controls. Additionally, eGr slightly decreased bone turnover markers that were increased by OVX. Therefore, it may be suggested that the protective effects of eGr could have originated from the suppression of OVX-induced increase in bone turnover. Collectively, the findings of this study indicate that eGr has potential to activate bone remodeling by inhibiting osteoclast differentiation and bone loss.

Focal plane AIT sequence: evolution from HRG-Spot 5 to Pleiades HR

Science.gov (United States)

Le Goff, Roland; Pranyies, Pascal; Toubhans, Isabelle

2017-11-01

Optical and geometrical image qualities of Focal Planes, for "push-broom" high resolution remote sensing satellites, require the implementation of specific means and methods for the AIT sequence. Indeed the geometric performances of the focal plane mainly axial focusing and transverse registration, are duly obtained on the basis of adjustment, setting and measurement of optical and CCD components with an accuracy of a few microns. Since the end of the 1970s, EADS-SODERN has developed a series of detection units for earth observation instruments like SPOT and Helios. And EADS-SODERN is now responsible for the development of the Pleiades High Resolution Focal Plane assembly. This paper presents the AIT sequences. We introduce all the efforts, innovative solutions and improvements made on the assembly facilities to match the technical evolutions and breakthrough of the Pleiades HR FP concept in comparison with the previous High Resolution Geometric SPOT 5 Focal Plane. The main evolution drivers are the implementation of strip filters and the realization of 400 mm continuous retinas. For Pleiades HR AIT sequence, three specific integration and measuring benches, corresponding with the different assembly stages, are used: a 3-D non-contact measurement machine for the assembly of detection module, a 3-D measurement machine for mirror integration on the main Focal Plane SiC structure, and a 3-D geometric coordinates control bench to focus detection module lines and to ensure they are well registered together.

Factors affecting the accumulation of curcumin in microrhizomes of Curcuma aromatica Salisb.

Science.gov (United States)

Wu, Ke; Zhang, Xiaoxia; Sun, Shulan; Wang, Xiaojing

2015-01-01

Curcuminoids, and mainly curcumin, are potential therapeutic agents for the prevention of various diseases; however, little is known about the factors that influence their accumulation in Curcuma species. In this study, the effects of factors such as sucrose concentration, different ratios of 6-benzylaminopurine (6-BA) and α-naphthalene acetic acid (NAA), and light quality on the accumulation of curcumin and other curcuminoids in Curcuma aromatica were investigated. Microrhizomes grown on media containing 3% sucrose produced more curcumin and other curcuminoids than those grown on higher concentrations. Moreover, when compared to other ratios of 6-BA and NAA, microrhizomes induced on 3% sucrose media supplemented with 3.0 mg/L 6-BA and 0.5 mg/L NAA produced more curcumin and other curcuminoids; however, the amount was less than in microrhizomes grown on 3% sucrose alone. We determined that a 5% sucrose medium supplemented with 3.0 mg/L of 6-BA and 0.5 mg/L of NAA enhanced the levels of curcumin and curcuminoids and that exposure to red light further increased production.

Changes of plasma ET and serum IgE levels in children with asthma before and after allergen immunotherapy (AIT)

International Nuclear Information System (INIS)

Dai Yunhai; Cheng Guanghua; Xie Jiazhen

2007-01-01

Objective: To investigate the relationship between the changes of plasma ET-1, serum IgE levels and allergen immunotherapy(AIT) in children with asthma. Methods: Plasma levels of ET-1 and serum levels of IgE were measured with radioimmunoassay in 46 children with asthma before and after allergen immunotherapy. Results: In 35 patients benefited from allergen immunotherapy, the plasma levels of ET-1 (59.1 ± 11.7pg/ml) and serum levels of IgE (11.1 ± 3.2IU/ml) were higher significantly than those in controls (P 0.05, respectively). Conclusion: These data suggested that the changes of ET-1 and IgE levels after AIT may play an important role in the effective treatment of asthma with AIT. (authors)

Ultrasonic Extraction of Antioxidants from Chinese Sumac (Rhus typhina L.) Fruit Using Response Surface Methodology and Their Characterization

OpenAIRE

Lai, Jixiang; Wang, Huifang; Wang, Donghui; Fang, Fang; Wang, Fengzhong; Wu, Tao

2014-01-01

For the first time, response surface methodology (RSM) using a Box-Behnken Design (BBD) was employed to optimize the conditions for ultrasonic assisted extraction (UAE) of antioxidants from Chinese sumac (Rhus typhina L.) fruits. Initially, influencing factors such as liquid-solid ratio, duration of ultrasonic assisted extraction, pH range, extraction temperature and ethanol concentration were identified using single-factor experiments. Then, with respect to the three most significant influen...

Chemical composition and inhibitory activities on dipeptidyl peptidase IV and pancreatic lipase of two underutilized species from the Brazilian Savannah: Oxalis cordata A.St.-Hil. and Xylopia aromatica (Lam.) Mart.

Science.gov (United States)

Oliveira, Verena B; Araújo, Raquel L B; Eidenberger, Thomas; Brandão, Maria G L

2018-03-01

Brazil has the greatest vegetal biodiversity in the world, but products derived from native species are not optimally utilized. Oxalis cordata and Xylopia aromatica are two underutilized species whose leaves and fruits, respectively, have been used as food in the 19th century. In this study, we used chemical and in vitro assays to evaluate the potential of these species as functional foods. The inhibitory activity on pancreatic lipase and DPP-IV were evaluated using the crude extracts and fractions ethyl acetate, butanol and water of these two species. For polyphenols determination, samples were prepared with different solvents and these were analysed by chromatographic and spectroscopic methods. Finally, fatty acids profile was determinated by gas chromatography. The crude extract (IC 50 =0.84mg/ml), ethyl acetate extract (IC 50 =0.88mg/ml) an aqueous fraction (IC 50 =0.63mg/ml) of C. cordata were inhibitory on pancreatic lipase but inactive against dipeptidyl peptidase IV (DPP-IV). Extracts from X. aromatica were inactive against the lipase pancreatic enzyme, but a butanolic fraction inhibited DPP-IV (IC 50 =0.71±0.05mg/ml). The phenolic acids orientin/isorientin, chlorogenic acid (0.32g/100g) and the flavonoid derivatives rutin (0.27g/100g), quercetin and luteolin were observed in all products. Additionally, fatty acid quantification showed that oleic (7.5g/100g) and linoleic acid (6.5g/100g) were predominant in X. aromatica fruit. This study confirms the potential for the use of both plants as functional foods due to their nutritional value, biological activity and important phytochemical content. Copyright © 2017 Elsevier Ltd. All rights reserved.

Phylogeny of Rhus gall aphids (Hemiptera:Pemphigidae) based on combined molecular analysis of nuclear EF1α and mitochondrial COII genes

Science.gov (United States)

Zi-xiang Yang; Xiao-ming Chen; Nathan P. Havill; Ying Feng; Hang. Chen

2010-01-01

Rhus gall aphids (Fordinae : Melaphidini) have a disjunct distribution in East Asia and North America and have specific host plant relationships. Some of them are of economic importance and all species form sealed galls which show great variation in shape, size, structure, and galling-site. We present a phylogeny incorporating ten species and four...

Analytical solution for haze values of aluminium-induced texture (AIT) glass superstrates for a-Si:H solar cells.

Science.gov (United States)

Sahraei, Nasim; Forberich, Karen; Venkataraj, Selvaraj; Aberle, Armin G; Peters, Marius

2014-01-13

Light scattering at randomly textured interfaces is essential to improve the absorption of thin-film silicon solar cells. Aluminium-induced texture (AIT) glass provides suitable scattering for amorphous silicon (a-Si:H) solar cells. The scattering properties of textured surfaces are usually characterised by two properties: the angularly resolved intensity distribution and the haze. However, we find that the commonly used haze equations cannot accurately describe the experimentally observed spectral dependence of the haze of AIT glass. This is particularly the case for surface morphologies with a large rms roughness and small lateral feature sizes. In this paper we present an improved method for haze calculation, based on the power spectral density (PSD) function of the randomly textured surface. To better reproduce the measured haze characteristics, we suggest two improvements: i) inclusion of the average lateral feature size of the textured surface into the haze calculation, and ii) considering the opening angle of the haze measurement. We show that with these two improvements an accurate prediction of the haze of AIT glass is possible. Furthermore, we use the new equation to define optimum morphology parameters for AIT glass to be used for a-Si:H solar cell applications. The autocorrelation length is identified as the critical parameter. For the investigated a-Si:H solar cells, the optimum autocorrelation length is shown to be 320 nm.

[AIT (Adolescent Identity Treatment) - an Integrative Treatment Model for the Treatment of Personality Disorders].

Science.gov (United States)

Schlüter-Müller, Susanne

2017-07-01

AIT (Adolescent Identity Treatment) - an Integrative Treatment Model for the Treatment of Personality Disorders Personality disorders are patterns of maladaptive personality traits that have an impact on the individual throughout the life span. Borderline Personality Disorder (BPD) is a very severe, but treatable mental disorder. Identity disturbance is seen as the central construct for detecting severe personality pathology - and, most notably, borderline personality disorder - in adults and adolescents. Crises in the development of identity usually resolve into a normal and consolidated identity with flexible and adaptive functioning whereas identity diffusion is viewed as a lack of integration of the concept of the self and significant others. It is seen as the basis for subsequent personality pathology, including that of borderline personality disorder. Although BPD has its onset in adolescence and emerging adulthood the diagnosis is often delayed. In most cases, specific treatment is only offered late in the course of the disorder and to relatively few individuals. Adolescent Identity Treatment (AIT) is a treatment model that focuses on identity pathology as the core characteristic of personality disorders. This model integrates specific techniques for the treatment of adolescent personality pathology on the background of object-relation theories and modified elements of Transference-Focused Psychotherapy. Moreover, psychoeducation, a behavior-oriented homeplan and intensive family work is part of AIT.

Raikküla mõisa ait-kuivatist ja selle taastamisest / Karen Klandorf

Index Scriptorium Estoniae

Klandorf, Karen

2014-01-01

Täpne valmimisaeg ei ole teada, kuid 1864. aastal on mainitud seda kui vana hoonet. 1909. aastal ehitati juurde kuivati. Mõisa ait-kuivati on traditsiooniline ehitis, mille muudavad erandlikuks pikkkaaristu ja hoone katusel ilutsev kellatorn. Kuivati esindab üht levinumat kuivatitüüpi. Restaureerimistööd kestsid 2008-2013.

Chloroplast microsatellites reveal population genetic diversity in red pine, Pinus resinosa Ait

Science.gov (United States)

Craig S. Echt; L.L. DeVerno; M. Anzidei; G.G. Vendramin

1998-01-01

Variation in paternally inherited chloroplast microsatellite (cpSSR) DNA was used to study population genetic structure in red pine (Pinus resinosa Ait.), a species characterized by morphological uniformity, no allozyme variation, and limited RAPD variation. Using nine cpSSR loci, a total of 23 chloroplast haplotypes and 25 cpSSR alleles were were...

Biosynthesis of gallic and ellagic acids with 14C-labeled compounds in Acer and Rhus leaves

International Nuclear Information System (INIS)

Ishikura, Nariyuki; Hayashida, Shunzo; Tazaki, Kiyoshi

1984-01-01

The biosynthetic pathway for gallic and ellagic acids in young, mature and autumn leaves of Acer buergerianum and Rhus succedanea was examined by tracer experiments, and also by isotope competition, with D-shikimic acid- 14 C, L-phenylalanine-U- 14 C, L-phenyllactic acid-U- 14 C, gallic acid-G- 14 C and their unlabeled compounds. In young leaves of both plants, the incorporation rate of labeled shikimic acid into gallic acid was significantly higher than that of labeled phenylalanine, whereas in the mature and autumn leaves the latter was a good precursor rather than the former for the gallic acid biosynthesis. Therefore, two pathways for gallic acid formation, through β-oxidation of phenylpropanoid and through dehydrogenation of shikimic acid, could be operating in Acer and Rhus leaves, and the preferential pathway is altered by leaf age. In both plants, the incorporation rate of labeled phenyllactic acid during a 24 hr metabolic period was almost the same as that of labeled phenylalanine. The incorporation of D-shikimic acid-G- 14 C, L-phenylalanine-U- 14 C and L-phenyllactic acid-U- 14 C into ellagic acid was very similar to the case of the radioactive gallic acid formation. Furthermore, regardless of the presence of unlabeled shikimic acid and/or phenylalanine, incorporation of the radioactivity of labeled gallic acid into ellagic acid occurred at a very high rate, suggesting the reciprocal radical reaction of gallic acid for the ellagic acid formation. The incorporation of labeled compounds into ellagitannins was also examined and their biosynthesis discussed further. (author)

Flavonoids with DNA strand-scission activity from Rhus javanica var. roxburghiana.

Science.gov (United States)

Lin, Chun-Nan; Chen, Hui-Ling; Yen, Ming-Hong

2008-01-01

The flavonoids isolated from the stems of Rhus javanica var. roxburghiana, taxifolin (1), fisetin (2), fustin (3), 3,7,4'-trihydroxyflavanone (4) and 3,7,4'-trihydroxyflavone (5) caused breakage of supercoiled plasmid pBR322 DNA in the presence of Cu(II). Cu(I) was shown to be an essential intermediate by using the Cu(I)-specific sequestering reagent neocuproine. The Cu(II)-mediated DNA scissions induced by 1, 2, 3 and 5 were inhibited by the addition of catalase and exhibited DNA strand break by the addition of KI and superoxide dimutase (SOD), while in the Cu(II)-mediated DNA scissions induced by 4 was inhibited by the addition of KI, SOD, and catalase. It is concluded that 1, 2, 3, and 5 can induce H2O2 and superoxide anion, while 4 can induce OH* and H2O2 and subsequent oxidative damage of DNA in the presence of Cu(II).

Antifungal Activity of Leaf and Latex Extracts of Calotropis procera (Ait.) against Dominant Seed-Borne Storage Fungi of Some Oil Seeds

OpenAIRE

Manoorkar V B; Mandge S V; B D Gachande

2015-01-01

In present study, aqueous and ethanol extracts of leaf & latex of Calotropis procera (Ait.) was tested for their antifungal activity against dominant storage seed-borne fungi of some oil seeds such as groundnut, soybean, sunflower and mustard. The antifungal effect of ethanol and aqueous extracts of leaf & latex of Calotropis procera (Ait.) against ten seed-borne dominant fungi viz., Cuvularia lunata, Alternaria alternata, Rhizoctonia solani, Fusarium solani, Penicillium chrysogenum, Asperg...

Isolation and Characterization of Polymorphic Microsatellite Loci in Spondias radlkoferi (Anacardiaceae

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Esther Aguilar-Barajas

2014-11-01

Full Text Available Premise of the study: Microsatellite markers were developed for Spondias radlkoferi to assess the impact of primate seed dispersal on the genetic diversity and structure of this important tree species of Anacardiaceae. Methods and Results: Fourteen polymorphic loci were isolated from S. radlkoferi through 454 GS-FLX Titanium pyrosequencing of genomic DNA. The number of alleles ranged from three to 12. The observed and expected heterozygosities ranged from 0.382 to 1.00 and from 0.353 to 0.733, respectively. The amplification was also successful in S. mombin and two genera of Anacardiaceae: Rhus aromatica and Toxicodendron radicans. Conclusions: These microsatellite loci will be useful to assess the genetic diversity and population structure of S. radlkoferi and related species, and will allow us to investigate the effects of seed dispersal by spider monkeys (Ateles geoffroyi on the genetic structure and diversity of S. radlkoferi populations in a fragmented rainforest.

Anatomia comparada do lenho de Xylopia aromatica (Lam.) Mart. em áreas de cerrado e de plantação de Pinus elliottii Engelm.

OpenAIRE

Luchi, Agnes E.; Silva, Luiz C. Pereira; Moraes, Marcelo A.

2005-01-01

A estrutura anatômica do lenho de Xylopia aromatica (Lam.) Mart. foi analisada pela observação do caule e da raiz de espécimes provenientes de duas áreas de cerrado, uma com vegetação característica e outra, em que a vegetação original foi substituída por monocultura de Pinus elliotti Engelm. As duas áreas situam-se na Reserva Biológica e Estação Experimental de Moji-Guaçu. As amostras foram coletadas pelo método não destrutivo. Os dados quantitativos das características analisadas foram obti...

Biological characterization of young and aged embryogenic cultures of Pinus pinaster (Ait.)

OpenAIRE

Klimaszewska, Krystyna; Noceda, Carlos; Pelletier, Gervais; Label, Philippe; Rodriguez, Roberto; Lelu-Walter, Marie-Anne

2009-01-01

Pinus pinaster (Ait.) somatic embryogenesis (SE) has been developed during the last decade, and its application in tree improvement programs is underway. Nevertheless, a few more or less important problems still exist, which have an impact on the efficiency of specific SE stages. One phenomenon, which had been observed in embryogenic tissue (embryonal mass, EM) initiated from immature seed, has been the loss of the ability to produce mature somatic embryos after the tissue had been cultured f...

Tweeting AI: Perceptions of AI-Tweeters (AIT) vs Expert AI-Tweeters (EAIT)

OpenAIRE

Manikonda, Lydia; Dudley, Cameron; Kambhampati, Subbarao

2017-01-01

With the recent advancements in Artificial Intelligence (AI), various organizations and individuals started debating about the progress of AI as a blessing or a curse for the future of the society. This paper conducts an investigation on how the public perceives the progress of AI by utilizing the data shared on Twitter. Specifically, this paper performs a comparative analysis on the understanding of users from two categories -- general AI-Tweeters (AIT) and the expert AI-Tweeters (EAIT) who ...

Antibacterial Activity of Rhus javanica against Methicillin-Resistant Staphylococcus aureus

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Yong-Ouk You

2013-01-01

Full Text Available In the present study, the leaves of Rhus javanica (R. javanica were extracted with ethanol, and we investigated the antimicrobial activity of the ethanol extract of R. javanica against methicillin-resistant Staphylococcus aureus (MRSA. Control groups were treated with media containing 0.1% DMSO. The ethanol extract of R. javanica inhibited the growth of MRSA at concentrations ranging from 0.05 to 0.2 mg/mL and inhibited acid production at concentrations higher than 0.1 mg/mL (P<0.05. MRSA biofilm formation was determined by scanning electron microscopy and safranin staining. The ethanol extract of R. javanica inhibited the formation of MRSA biofilms at concentrations higher than 0.05 mg/mL. In confocal laser scanning microscopy, high concentration (0.4–1.6 mg/mL of R. javanica extract showed bactericidal effect in a dose-dependent manner. In real-time PCR analysis, R. javanica extract showed the inhibition of the genetic expression of virulence factors such as mecA, sea, agrA, and sarA in MRSA. Preliminary phytochemical analysis revealed the strong presence of phenolics. These results suggest that R. javanica may be a useful medicinal plant for inhibiting MRSA, which may be related to the presence of phenolics in the R. javanica extract.

Rhus verniciflua Stokes against Advanced Cancer: A Perspective from the Korean Integrative Cancer Center

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Woncheol Choi

2012-01-01

Full Text Available Active anticancer molecules have been searched from natural products; many drugs were developed from either natural products or their derivatives following the conventional pharmaceutical paradigm of drug discovery. However, the advances in the knowledge of cancer biology have led to personalized medicine using molecular-targeted agents which create new paradigm. Clinical benefit is dependent on individual biomarker and overall survival is prolonged through cytostatic rather than cytotoxic effects to cancer cell. Therefore, a different approach is needed from the single lead compound screening model based on cytotoxicity. In our experience, the Rhus verniciflua stoke (RVS extract traditionally used for cancer treatment is beneficial to some advanced cancer patients though it is herbal extract not single compound, and low cytotoxic in vitro. The standardized RVS extract's action mechanisms as well as clinical outcomes are reviewed here. We hope that these preliminary results would stimulate different investigation in natural products from conventional chemicals.

Optimization of surface morphology and scattering properties of TCO/AIT textured glass front electrode for thin film solar cells

Energy Technology Data Exchange (ETDEWEB)

Addonizio, M.L., E-mail: marialuisa.addonizio@enea.it; Fusco, L.; Antonaia, A.; Cominale, F.; Usatii, I.

2015-12-01

Graphical abstract: - Highlights: • Aluminium induced texture (AIT) method has been used for obtaining highly textured glass substrates. • The effect of wet etch step on morphological and optical properties has been analyzed. • The morphology features have been optimized in order to obtain the best scattering properties. • Different ZnO surface textures, depending on the underlying glass substrate structures, are obtained. • The effect of different glass texture on optical confinement has been tested in a-Si:H devices. - Abstract: Aluminium induced texture (AIT) method has been used for obtaining highly textured glass substrate suitable for silicon based thin film solar cell technology. Wet etch step parameters of AIT process have been varied and effect of different etchants and different etching times on morphological and optical properties has been analyzed. The resulting morphology features (shape, size distribution, inclination angle) have been optimized in order to obtain the best scattering properties. ZnO:Ga (GZO) films have been deposited by sputtering technique on AIT-processed glass. Two different ZnO surface morphologies have been obtained, strongly depending on the underlying glass substrate morphology induced by different etching times. Very rough and porous texture (σ{sub rms} ∼ 150 nm) was obtained on glass etched 2 min showing cauliflower-like structure, whereas a softer texture (σ{sub rms} ∼ 78 nm) was obtained on glass etched 7 min giving wider and smoother U-shaped craters. The effect of different glass textures on optical confinement has been tested in amorphous silicon based p-i-n devices. Devices fabricated on GZO/high textured glass showed a quantum efficiency enhancement due to both an effective light trapping phenomenon and an effective anti-reflective optical behaviour. Short etching time produce smaller cavities (<1 μm) with deep U-shape characterized by high roughness, high inclination angle and low autocorrelation

Seasonal changes in contents of phenolic compounds and sugar in Rhus, Euonymus and Acer leaves with special reference to anthocyanin formation in autumn

International Nuclear Information System (INIS)

Ishikura, Nariyuki

1976-01-01

The seasonal changes in the contents of sugar and phenolic compounds in the leaves of Rhus, Euonymus and two Acer species were examined in order to obtain information on the metabolic process inducing the autumn reddening. The incorporation of radioactivity of glucose-(U-14C) into anthocyanin was also examined. As a result of a preliminary test, the compositions of sugar and phenolic compounds were not altered by the drying treatment, therefore dried material was used. Dried leaves (ca. 2 g) were subject to the extraction with 80% methanol (3 ml, 3 hr) under refluxing. The extraction was repeated twice. Combined extracts (ca. 90 ml) were concentrated to ca. 20 ml at 35 deg C under reduced pressure. The concentrate was repeatedly washed with n-hexane and evaporated to remove the n-hexane. The resulting solution was made up to 30 ml with water, and used for the quantitative analysis. The solutions were fractionated in order to estimate total phenol and flavanol contents. Sugars were extracted from dry leaves (ca. 2 g) by boiling 70% ethanol (20 ml) for 3 hours. D-glucose-(U- 14 C)(280 mCi/mM) and phenylalanine-(U- 14 C)(422 mCi/mM) were fed to the leaves. It was found that antho-cyanin (mainly cyanidin 3-monoglucoside) was produced in the autumnal leaves of all plants examined, and that the red pigment was steadily accumulated in their leaves during the autumn. The sugar accumulated in autumnal Rhus leaves may be rapidly consumed by the formation of phenolic compounds. (Iwakiri, K.)

Human and animal health risk assessment of metal contamination in soil and plants from Ait Ammar abandoned iron mine, Morocco.

Science.gov (United States)

Nouri, Mohamed; Haddioui, Abdelmajid

2016-01-01

The goal of this paper is to investigate metal pollution in food chain and assess the resulting health risks to native citizens in Ait Ammar village. The results showed that cadmium (Cd), lead (Pb), and copper (Cu) concentrations in animal organs were above the metal concentration safety limit. Nevertheless, soils and plants from mining area were contaminated with iron (Fe), chromium (Cr), zinc (Zn), and Cr, Cu, Zn respectively. Cd concentrations in almost animal organs were higher than the acceptable daily upper limit, suggesting human consumption of this livestock meat and offal may pose a health risk. The estimated intake of Pb and Cd for Ait Ammar population could be a cause of concern because it exceeded the Provisional Tolerable Weekly Intake (PTWI) proposed by Joint Expert Committee on Food Additives (JECFA) in this area. Thus, conducting regular periodic studies to assess the dietary intake of mentioned elements are recommended.

Investigation of antibacterial effects of ethanolic extract of Sumac (Rhus coriaria L. against Escherichia coli in vitro

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H Moshtaghi

2013-08-01

Full Text Available The antibacterial effect of etbhanolic extract of Sumac (Rhus coriaria L. was investigated quantitatively and qualitatively on Escherichia coli. The results of well diffusion test showed that extracts of Sumac in concentration of 0.5%, 1%, 2.5% and 5% could inhibited E. coli. In this study it was shown that MIC of the alcoholic extract of Sumac against E. coli was 6.25 mg/ml and its MBC against this bacterium was 50 mg/ml. The results from evaluation of the antibacterial effects of the Sumac revealed that at 4 and 15 °C, the growth of E. coli in test tubes containing meat extracts has increased Throughout the 48 h of incubation period. Results showed that the growth of this bacteria in different concentration of Sumac extract as decreased in the both tested temperatures in comparison to time zero (p

Construction of a high-density American cranberry (Vaccinium macrocarpon Ait.) composite map using genotyping-by-sequencing for multi-pedigree linkage mapping

Science.gov (United States)

The American cranberry (Vaccinium macrocarpon Ait.) is a recently domesticated, but economically important, fruit crop with limited molecular resources. New genetic resources could accelerate genetic gain in cranberry through characterization of its genomic structure and by enabling molecular-assist...

Assessment of metals contamination and ecological risk in ait Ammar abandoned iron mine soil, Morocco

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Nouri Mohamed

2016-03-01

Full Text Available The present study is an attempt to assess the pollution intensity and corresponding ecological risk of phosphorus and metals including Cd, Cr, Cu, Zn, Pb and Fe using various indices like geo-accumulation index, enrichment factor, pollution and ecological risk index. In all, 20 surface soil samples were collected from the Ait Ammar iron mine of Oued Zem city, province of Khouribga, in central Morocco. The concentrations of heavy metals in soil samples were used to assess their potential ecological risks. According to the results of potential ecological risk index (RI, pollution index (PI, geo-accumulation index (Igeo, enrichment factor (EF, potential contamination index (Cp, contaminant factor (Cf and degree of contamination (Cd, based on the averages, considerable pollution of metals in soils of study area was observed. The consequence of the correlation matrix and principal component analysis (PCA indicated that Fe, Cu, Zn, Cr and P mainly originated from natural sources and Cd and Pb are mostly derived from anthropogenic sources. The results showed that these metals in soil were ranked by severity of ecological risk as Pb > Cd > Cu > Cr > Zn, based on their single-element indexes. In view of the potential ecological risk (RI, soils from all soil samples showed a potential ecological risk. These results will provide basic information for the improvement of soil environment management and heavy metal pollution prevention in Ait Ammar.

Extract of Rhus verniciflua Bark Suppresses 2,4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis

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Dong Ki Park

2013-01-01

Full Text Available Rhus verniciflua Stokes (RV has traditionally been used as a food supplement and a traditional herbal medicine for centuries in Korea. Recent studies suggest that RV has potent antioxidative, antitumor, and anti-inflammatory properties. In this study, the anti-inflammatory effects of RV from mice sensitized with 2,4-dinitrofluorobenzene (DNFB and activated macrophages were investigated. The results showed that RV reduced ear swelling and hyperplasia of ear tissue as well as an increase in vascular permeability, which are characteristics of allergic contact dermatitis (ACD with evident histomorphological changes in epidermis and dermis. Decreased numbers of infiltrated mast cells were seen in RV extract treated group, using toluidine blue staining. RV extract significantly regulates the expression of inducible nitric oxide synthase (iNOS at the translational level in activated macrophages. Furthermore, RV extract and its active compound, fisetin, attenuated the level of tumor necrosis factor-α (TNF-α and interleukin 6 (IL-6 mRNA in LPS-stimulated macrophages. Anti-ACD effect of RV extract may be due to the suppression of iNOS and proinflammatory cytokines which might be mediated via the NFκB signaling pathways. Collectively, RV extract has potential for alleviating ACD-like symptoms induced by DNFB in the mouse.

Effects of rainfall exclusion on leaf gas exchange traits and osmotic adjustment in mature canopy trees of Dryobalanops aromatica (Dipterocarpaceae) in a Malaysian tropical rain forest.

Science.gov (United States)

Inoue, Yuta; Ichie, Tomoaki; Kenzo, Tanaka; Yoneyama, Aogu; Kumagai, Tomo'omi; Nakashizuka, Tohru

2017-10-01

Climate change exposes vegetation to unusual levels of drought, risking a decline in productivity and an increase in mortality. It still remains unclear how trees and forests respond to such unusual drought, particularly Southeast Asian tropical rain forests. To understand leaf ecophysiological responses of tropical rain forest trees to soil drying, a rainfall exclusion experiment was conducted on mature canopy trees of Dryobalanops aromatica Gaertn.f. (Dipterocarpaceae) for 4 months in an aseasonal tropical rain forest in Sarawak, Malaysia. The rainfall was intercepted by using a soft vinyl chloride sheet. We compared the three control and three treatment trees with respect to leaf water use at the top of the crown, including stomatal conductance (gsmax), photosynthesis (Amax), leaf water potential (predawn: Ψpre; midday: Ψmid), leaf water potential at turgor loss point (πtlp), osmotic potential at full turgor (π100) and a bulk modulus of elasticity (ε). Measurements were taken using tree-tower and canopy-crane systems. During the experiment, the treatment trees suffered drought stress without evidence of canopy dieback in comparison with the control trees; e.g., Ψpre and Ψmid decreased with soil drying. Minimum values of Ψmid in the treatment trees decreased during the experiment, and were lower than πtlp in the control trees. However, the treatment trees also decreased their πtlp by osmotic adjustment, and the values were lower than the minimum values of their Ψmid. In addition, the treatment trees maintained gs and Amax especially in the morning, though at midday, values decreased to half those of the control trees. Decreasing leaf water potential by osmotic adjustment to maintain gs and Amax under soil drying in treatment trees was considered to represent anisohydric behavior. These results suggest that D. aromatica may have high leaf adaptability to drought by regulating leaf water consumption and maintaining turgor pressure to improve its leaf

Managing succession in conifer plantations: converting young red pine (Pinus resinosa Ait.) plantations to native forest types by thinning and underplantiing

Science.gov (United States)

William C. Parker; Ken A. Elliott; Daniel C. Dey; Eric Boysen; Steven G. Newmaster

2001-01-01

The effects of thinning on growth and survival of white pine (Pinus strobus L.), white ash (Fraxinus americana L.), and red oak (Quercus rubra L.), and understory plant diversity were examined in a young red pine (Pinus resinosa Ait.) plantation. Five years after thinning, seedling diameter,...

Ultrasonic extraction of antioxidants from Chinese sumac (Rhus typhina L.) fruit using response surface methodology and their characterization.

Science.gov (United States)

Lai, Jixiang; Wang, Huifang; Wang, Donghui; Fang, Fang; Wang, Fengzhong; Wu, Tao

2014-06-27

For the first time, response surface methodology (RSM) using a Box-Behnken Design (BBD) was employed to optimize the conditions for ultrasonic assisted extraction (UAE) of antioxidants from Chinese sumac (Rhus typhina L.) fruits. Initially, influencing factors such as liquid-solid ratio, duration of ultrasonic assisted extraction, pH range, extraction temperature and ethanol concentration were identified using single-factor experiments. Then, with respect to the three most significant influencing factors, the extraction process focusing on the DPPH· scavenging capacity of antioxidants was optimized using RSM. Results showed that the optimal conditions for antioxidant extraction were 13.03:1 (mL/g) liquid-solid ratio, 16.86 min extraction time and 40.51% (v/v) ethanol, and the desirability was 0.681. The UPLC-ESI-MS analysis results revealed eleven kinds of phenolic compounds, including four major rare anthocyanins, among the antioxidants. All these results suggest that UAE is efficient at extracting antioxidants and has the potential to be used in industry for this purpose.

Fungos endofíticos de Calotropis procera (AIT.) R. BR.: aspectos ecológicos e potencial antimicrobiano

OpenAIRE

NASCIMENTO, Tatianne Leite

2010-01-01

Fungos endofíticos são micro-organismos que colonizam assintomaticamente, intra e/ou intercelularmente, tecidos sadios de plantas em algum período do seu ciclo de vida. Estes despertaram grande interesse biotecnológico em virtude da aplicabilidade de seus metabólitos secundários na medicina, indústria e agricultura. Calotropis procera (Ait.) R. Br. (Apocynaceae) é uma planta medicinal muito utilizada nas regiões de origem (Ásia e África) com comprovado potencial farmacológico, ...

Ultrasonic Extraction of Antioxidants from Chinese Sumac (Rhus typhina L. Fruit Using Response Surface Methodology and Their Characterization

Directory of Open Access Journals (Sweden)

Jixiang Lai

2014-06-01

Full Text Available For the first time, response surface methodology (RSM using a Box-Behnken Design (BBD was employed to optimize the conditions for ultrasonic assisted extraction (UAE of antioxidants from Chinese sumac (Rhus typhina L. fruits. Initially, influencing factors such as liquid-solid ratio, duration of ultrasonic assisted extraction, pH range, extraction temperature and ethanol concentration were identified using single-factor experiments. Then, with respect to the three most significant influencing factors, the extraction process focusing on the DPPH· scavenging capacity of antioxidants was optimized using RSM. Results showed that the optimal conditions for antioxidant extraction were 13.03:1 (mL/g liquid-solid ratio, 16.86 min extraction time and 40.51% (v/v ethanol, and the desirability was 0.681. The UPLC-ESI-MS analysis results revealed eleven kinds of phenolic compounds, including four major rare anthocyanins, among the antioxidants. All these results suggest that UAE is efficient at extracting antioxidants and has the potential to be used in industry for this purpose.

Antibacterial and antioxidant activities of an ethno botanically important plant sauromatum venosum (ait.) schott. of district Kotli, Azad Jammu and Kashmir

International Nuclear Information System (INIS)

Ajaib, M.; Khan, Z.U.D.; Abbadi, M.A.; Khan, N.; Wahab, M.

2011-01-01

In order to verify the ethnopharmacological effects of local plant, Sauromatum venosum (Ait.) Schott., on scientific lines the antibacterial activity including MIC and antioxidant activity of the crude extracts of its fruits were tested against Gram-positive and Gram-negative bacteria using well diffusion method and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity test. The results indicated a reasonable antibacterial potential and significant total antioxidant activity, thus supporting its traditional medicinal practices. (author)

Photosynthesis and fluctuating asymmetry as indicators of plant response to soil disturbance in the Fall-Line Sandhills of Georgia: a case study using Rhus copallinum and Ipomoea pandurata

Science.gov (United States)

Freeman, D. Carl; Brown, Michelle L.; Duda, Jeffrey J.; Graham, John H.; Emlen, John M.; Krzysik, Anthony J.; Balbach, Harold E.; Kovacic, David A.; Zak, John C.

2004-01-01

We examined net photosynthesis, transpiration, stomatal conductance, and leaf fluctuating asymmetry on two species (Rhus copallinum and Ipomoea pandurata) as indicators of stress at nine sites across a gradient of soil disturbance at Fort Benning, Georgia. There were three sites for each of three disturbance levels. Physical habitat disturbance was caused by activities associated with infantry training, including mechanized elements (tanks and personnel carriers) and foot soldiers. In addition, we examined the influence of prescribed burns and microhabitat effects (within meter‐square quadrats centered about the plant) on these measures of plant stress. Net photosynthesis declined with increasing disturbance in the absence of burning for both species. However, when sites were burned the previous year, net photosynthesis increased with increasing disturbance. Developmental instability in Rhus, as measured by fluctuating asymmetry, also declined with increasing disturbance in the absence of burning but increased with disturbance if sites were burned the previous year. Developmental instability was much less sensitive to burning in Ipomoea and in general was lowest at intermediate disturbance sites. Microenvironmental and microhabitat effects were weakly correlated with measures of plant stress when all sites were combined. However, higher correlations were obtained within site categories, especially when the recent history of prescribed burning was used as a category. Finally, using all of the combined data in a discriminant function analysis allowed us to correctly predict the disturbance level of more than 80% of the plants. Plant stress is responsive to both large‐scale perturbations, such as burning, and microhabitat parameters. Because of this, it is important to include macro‐ and microhabitat parameters when assessing stress. Similarly, we found a combination of developmental and physiological indicators of stress was superior to using them

Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy

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Saba Khalilpour

2018-04-01

Full Text Available Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria extract in vivo. The half maximal inhibitory concentration (IC50 for DPPH, ABTS and β–carotene were 6.79 ± 0.009 µg/mL, 10.94 ± 0.09 µg/mL, and 6.25 ± 0.06 µg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC and linoleic acid (LA on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT. Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy.

Characterization of Three L-Asparaginases from Maritime Pine (Pinus pinaster Ait.).

Science.gov (United States)

Van Kerckhoven, Sonia H; de la Torre, Fernando N; Cañas, Rafael A; Avila, Concepción; Cantón, Francisco R; Cánovas, Francisco M

2017-01-01

Asparaginases (ASPG, EC 3.5.1.1) catalyze the hydrolysis of the amide group of L-asparagine producing L-aspartate and ammonium. Three ASPG, PpASPG1, PpASPG2, and PpASPG3, have been identified in the transcriptome of maritime pine ( Pinus pinaster Ait.) that were transiently expressed in Nicotiana benthamiana by agroinfection. The three recombinant proteins were processed in planta to active enzymes and it was found that all mature forms exhibited double activity asparaginase/isoaspartyl dipeptidase but only PpASPG1 was able to catalyze efficiently L-asparagine hydrolysis. PpASPG1 contains a variable region of 77 amino acids that is critical for proteolytic processing of the precursor and is retained in the mature enzyme. Furthermore, the functional analysis of deletion mutants demonstrated that this protein fragment is required for specific recognition of the substrate and favors enzyme stability. Potassium has a limited effect on the activation of maritime pine ASPG what is consistent with the lack of a critical residue essential for interaction of cation. Taken together, the results presented here highlight the specific features of ASPG from conifers when compared to the enzymes from angiosperms.

Characterization of Three L-Asparaginases from Maritime Pine (Pinus pinaster Ait.

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Sonia H. Van Kerckhoven

2017-06-01

Full Text Available Asparaginases (ASPG, EC 3.5.1.1 catalyze the hydrolysis of the amide group of L-asparagine producing L-aspartate and ammonium. Three ASPG, PpASPG1, PpASPG2, and PpASPG3, have been identified in the transcriptome of maritime pine (Pinus pinaster Ait. that were transiently expressed in Nicotiana benthamiana by agroinfection. The three recombinant proteins were processed in planta to active enzymes and it was found that all mature forms exhibited double activity asparaginase/isoaspartyl dipeptidase but only PpASPG1 was able to catalyze efficiently L-asparagine hydrolysis. PpASPG1 contains a variable region of 77 amino acids that is critical for proteolytic processing of the precursor and is retained in the mature enzyme. Furthermore, the functional analysis of deletion mutants demonstrated that this protein fragment is required for specific recognition of the substrate and favors enzyme stability. Potassium has a limited effect on the activation of maritime pine ASPG what is consistent with the lack of a critical residue essential for interaction of cation. Taken together, the results presented here highlight the specific features of ASPG from conifers when compared to the enzymes from angiosperms.

Allergen-Removed Rhus verniciflua Extract Induces Ovarian Cancer Cell Death via JNK Activation.

Science.gov (United States)

Kang, Se-Hui; Hwang, In-Hu; Son, Eunju; Cho, Chong-Kwan; Choi, Jong-Soon; Park, Soo-Jung; Jang, Byeong-Churl; Lee, Kyung-Bok; Lee, Zee-Won; Lee, Jong Hoon; Yoo, Hwa-Seung; Jang, Ik-Soon

2016-01-01

Nuclear factor-[Formula: see text]B (NF-[Formula: see text]B)/Rel transcription factors are best known for their central roles in promoting cell survival in cancer. NF-[Formula: see text]B antagonizes tumor necrosis factor (TNF)-[Formula: see text]-induced apoptosis through a process involving attenuation of the c-Jun-N-terminal kinase (JNK). However, the role of JNK activation in apoptosis induced by negative regulation of NF-[Formula: see text]B is not completely understood. We found that allergen-removed Rhus verniciflua Stokes (aRVS) extract-mediated NF-[Formula: see text]B inhibition induces apoptosis in SKOV-3 ovarian cancer cells via the serial activation of caspases and SKOV-3 cells are most specifically suppressed by aRVS. Here, we show that in addition to activating caspases, aRVS extract negatively modulates the TNF-[Formula: see text]-mediated I[Formula: see text]B/NF-[Formula: see text]B pathway to promote JNK activation, which results in apoptosis. When the cytokine TNF-[Formula: see text] binds to the TNF receptor, I[Formula: see text]B dissociates from NF-[Formula: see text]B. As a result, the active NF-[Formula: see text]B translocates to the nucleus. aRVS extract (0.5[Formula: see text]mg/ml) clearly prevented NF-[Formula: see text]B from mobilizing to the nucleus, resulting in the upregulation of JNK phosphorylation. This subsequently increased Bax activation, leading to marked aRVS-induced apoptosis, whereas the JNK inhibitor SP600125 in aRVS extract treated SKOV-3 cells strongly inhibited Bax. Bax subfamily proteins induced apoptosis through caspase-3. Thus, these results indicate that aRVS extract contains components that inhibit NF-[Formula: see text]B signaling to upregulate JNK activation in ovarian cancer cells and support the potential of aRVS as a therapeutic agent for ovarian cancer.

Forest structure and plant diversity in maritime pine (Pinus pinaster Ait.) stands in central Spain

Energy Technology Data Exchange (ETDEWEB)

Osorio, L. F.; Bravo, F.; Zaldivar, P.; Pando, V.

2009-07-01

The relationship between forest structure and plant diversity in Mediterranean Maritime pine stands (Pinus pinaster Ait.) in the Iberian Range (Spain) was studied. Forty eight stands were sampled. In each, a circular plot (15 m radius) and a transect (25*1 m{sup 2}) were established to estimate stand variables and record presence and abundance of vascular species respectively. Canonical correlation analysis (CCA), simple correlations and multiple stepwise linear regressions were used to explore the relationship between plant diversity and forest structure. Correlation between diversity measurements and stand variables is very weak, but significant correlations were found when evaluating each set of variables separately. Presence and cover of some species (for instance, Veronica arvensis L. or Micropyrum tenellum (L.) Link) is correlated with stand variables; however, determination coefficients found in step-by-step regression are not significant. (Author) 34 refs.

Antiplatelet effects of Rhus verniciflua stokes heartwood and its active constituents--fisetin, butein, and sulfuretin--in rats.

Science.gov (United States)

Lee, Jun-Hyeong; Kim, Mikyung; Chang, Kyung-Hwa; Hong, Cheol Yi; Na, Chun-Soo; Dong, Mi-Sook; Lee, Dongho; Lee, Moo-Yeol

2015-01-01

Rhus verniciflua stokes (RVS) is known to promote blood circulation by preventing blood stasis, although the active ingredients and the underlying mechanism are unclear. Platelets are the primary cells that regulate circulation and contribute to the development of diverse cardiovascular diseases by aggregation and thrombosis. The study assessed the antiplatelet activity of RVS and sought to identify the active constituents. Pretreatment of washed platelets with RVS heartwood extract blunted the aggregatory response of platelets to collagen. In the subfractions, fisetin, butein, and sulfuretin were identified as effective inhibitors of platelet aggregation by collagen, thrombin, and adenosine-5'-diphosphate. Antiplatelet activities of all three compounds were concentration dependent, and fisetin had longer in vitro duration of action compared with butein or sulfuretin. Extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase activation by collagen was prevented by fisetin, whereas butein and sulfuretin failed to inhibit ERK and p38 activation was not affected by any of the compounds. Rats orally administered 100 mg/(kg·day(-1)) fisetin for 7 days were resistant to arterial thrombosis, although total extract of RVS heartwood exhibited little effect at a dose of 1000 mg/(kg·day(-1)). RVS heartwood may have cardiovascular protective activity by inhibiting platelet aggregation. The active constituents are fisetin, butein, and sulfuretin, and fisetin is orally effective against thrombosis.

Assessing wildfire occurrence probability in Pinus pinaster Ait. stands in Portugal

Energy Technology Data Exchange (ETDEWEB)

Marques, S.; Garcia-Gonzalo, J.; Botequim, B.; Ricardo, A.; Borges, J. G.; Tome, M.; Oliveira, M. M.

2012-11-01

Maritime pine (Pinus pinaster Ait.) is an important conifer from the western Mediterranean Basin extending over 22% of the forest area in Portugal. In the last three decades nearly 4% of Maritime pine area has been burned by wildfires. Yet no wildfire occurrence probability models are available and forest and fire management planning activities are thus carried out mostly independently of each other. This paper presents research to address this gap. Specifically, it presents a model to assess wildfire occurrence probability in regular and pure Maritime pine stands in Portugal. Emphasis was in developing a model based on easily available inventory data so that it might be useful to forest managers. For that purpose, data from the last two Portuguese National Forest Inventories (NFI) and data from wildfire perimeters in the years from 1998 to 2004 and from 2006 to 2007 were used. A binary logistic regression model was build using biometrics data from the NFI. Biometric data included indicators that might be changed by operations prescribed in forest planning. Results showed that the probability of wildfire occurrence in a stand increases in stand located at steeper slopes and with high shrubs load while it decreases with precipitation and with stand basal area. These results are instrumental for assessing the impact of forest management options on wildfire probability thus helping forest managers to reduce the risk of wildfires. (Author) 57 refs.

Sucukta Kullanılan Farklı Hayvan Türlerine ait Etlerin PCR Tekniği ile Belirlenmesi (İngilizce

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Zülal Kesmen

2015-02-01

Full Text Available Et ürünlerinde farklı hayvan türlerine ait etleri tespit etmek amacıyla son yıllarda PCR tekniği oldukça önem kazanmış ve mevcut yöntemlerin yerini alabilecek alternatif bir yöntem olarak öne çıkmıştır. Bu çalışmada geleneksel bir et ürünümüz olan sucukta at, eşek ve domuz türlerine ait etlerin tespitinde kullanılmak üzere spesifik bir PCR metodu geliştirilmiştir. Bu amaçla, sığır ve koyun etlerine at, eşek ve domuz etlerinden her birisi, farklı seviyelerde (%0.0, 0.1, 0.5, 1.0 ve 5.0 ilave edilerek hazırlanan ikili et karışımlarından sucuk örnekleri üretilmiştir. Mitokondrial DNA üzerinde at, eşek ve domuz türlerine spesifik (sırasıyla 153, 145 ve 227 baz çifti uzunluğunda fragment üreten oligonükleotid primerler dizayn edilmiş ve neticede sucuk örneklerinin hepsinde; her bir tür %0.1’den %5’kadar olan tüm seviyelerde tespit edilebilmiştir. Sonuç olarak, bu çalışma kapsamında geliştirilen spesifik PCR yönteminin, et ürünlerinde bulunabilecek at, eşek ve domuz etlerinin tespitinde ülkemiz gıda kontrol laboratuarlarının ihtiyacını giderecek, rutin bir kontrol metodu olabileceği ortaya konulmuştur.

Assessment of the variation of the moisture content in the Pinus pinaster Ait. using the non destructive GPR technique

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Díez Barra, R.

2011-03-01

Full Text Available The moisture content variations in wood have a significant influence in wood’s physicochemical properties, as well as in its electromagnetic properties and to specific effects upon waves’ characteristics. In particular, this paper focuses on the analysis of the Ground-penetrating Radar’s (GPR using an antenna of 1.6GHz central frequency capacity to register the velocity and the amplitude of the electromagnetic waves’ variation during the drying process of Pinus pinaster Ait timber joists. The results showed that when timber MC descends, the propagation velocity and amplitude of both the direct and the reflected wave increased. The high correlation found between the variables studied demonstrates GPR efficiency and the innovative application of this technique as a non-destructive evaluation tool for timber structures, particularly when studying its moisture content.La variación en el contenido de humedad (CH tiene una influencia significativa tanto en las propiedades físico- químicas de la madera, como en sus propiedades electromagnéticas y por tanto afecta a las características de la propagación de las ondas. En concreto, en este trabajo se estudia la capacidad del georradar (GR empleando una antena de 1.6GHz de frecuencia central para registrar las variaciones que se producen en la velocidad y en la amplitud de las ondas electromagnéticas cuando se propagan en unas viguetas de madera de Pinus pinaster Ait de uso estructural cuyo CH va disminuyendo. Se ha comprobado como cuando el CH descendía la velocidad de propagación y las amplitudes, tanto de la onda directa como de la reflejada aumentaba. Los altos factores de correlación encontrados demuestran que el GR es una técnica capaz de evaluar, de forma no destructiva, el CH de la madera de uso estructural.

Microelement contents and fatty acid compositions of Rhus coriaria L. and Pistacia terebinthus L. fruits spread commonly in the south eastern Anatolia region of Turkey.

Science.gov (United States)

Kizil, Suleyman; Turk, Murat

2010-01-01

Sumac (Rhus coriaria L.) and terebinth (Pistacia terebinthus L.) are two important spice plants of south eastern Anatolia, Turkey. Nutrients, physical properties including moisture, ash, dry matter, protein, fatty oil and essential oil content, along with Al, Ca, Cd, Cr, Cu, Fe, K, Mg, Na, Ni, Pb, Zn and characteristics of fruit sizes and fatty acid compositions of both plants were determined from ripe fruits. The free fatty acid content was determined in the fruit oil, and the main fatty acids of sumac and terebinth were identified by gas chromatography/mass spectrometry. They included oleic, linoleic, palmitic and stearic acids in a ratio of 37.7% and 34.8%, 27.4% and 17.3%, 21.1% and 21.7% and, 4.7% and 2.5%, respectively. The fruits of both plants were rich in oil, fatty acids and minerals, suggesting that they are valuable for using in food. The data may also be useful for the evaluation of nutritional information.

NCBI nr-aa BLAST: CBRC-XTRO-01-0305 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-XTRO-01-0305 ref|YP_285817.1| Heavy metal efflux pump CzcA [Dechloromonas arom...atica RCB] gb|AAZ47347.1| Heavy metal efflux pump CzcA [Dechloromonas aromatica RCB] YP_285817.1 0.0 74% ...

Cytotoxicity and antiangiogenic effects of Rhus coriaria, Pistacia vera and Pistacia khinjuk oleoresin methanol extracts.

Science.gov (United States)

Mirian, M; Behrooeian, M; Ghanadian, M; Dana, N; Sadeghi-Aliabadi, H

2015-01-01

Angiogenesis, formation of new blood vessels, play an important role in some diseases such as cancer and its metastasis. Using angiogenesis inhibitors, therefore, is one of the ways for cancer treatment and prevention of metastasis. Medicinal plants have been shown to play a major role in the treatment of a variety of cancers. In this direction, cytotoxic and angiogenic effects of oleo gum resin extracts of Rhus coriaria, Pistacia vera and Pistacia khinjuk from Anacardiaceae family were studied. For IC50 values, cytotoxic effects of the plant extracts were evaluated at different concentrations (1, 10, 20, 40, 80,100 μg/ml) against human umbilical vein endothelial normal cell (HUVEC) and Y79 cell lines using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. In vitro tube formation on matrigel base was used to evaluate angiogenic effects in the presence of increasing concentrations (50, 100, 250 μg/ml) of the extracts. Vascular endothelium growth factor was used as angiogenesis stimulator. Gas chromatography results showed that α-pinene and β-pinene were the major essential oils constituents of all plant extracts. According to the MTT assay results, the R. coriaria resin extract was more cytotoxic than those of P. vera and P. khinjuk extracts (IC50, 9.1 ± 1.6 vs 9.8 ± 2.1 and 12.0 ± 1.9, respectively; P<0.05). Cytotoxic effects of all extracts against Y79 cell line was significantly higher than those of HUVEC used as a normal cell line (P<0.05). Tube formation assay also showed that extract of R. coriaria resin inhibited angiogenesis more significantly than other tested extracts (P<0.05). It could be concluded that R. coriaria resin extract possess cytotoxic effect and antiangiogenesis against cancer cells and as an anticancer natural product has a good potential for future studies.

Determination of borneol and other chemical compounds of ...

African Journals Online (AJOL)

Purpose: To determine borneol and other chemical compounds of essential oil derived from the exudate of Dryobalanops aromatica in Malaysia. Methods: Exudate was collected from D. aromatica and subjected to fractional distillation to obtain essential oil. Gas chromatography-mass spectrometry (GC-MS) was performed ...

Chemical composition of essential oil of exudates of Dryobalanops ...

African Journals Online (AJOL)

Purpose: To identify the chemical composition of essential oil from the exudates of Dryobalanops aromatica from Malaysia. Methods: Exudate was collected from D. aromatica and subjected to fractional distillation to obtain essential oil. Gas chromatography-mass spectrometry (GC-MS) was used to characterize the ...

Organ-specific metabolic responses to drought in Pinus pinaster Ait.

Science.gov (United States)

de Miguel, Marina; Guevara, M Ángeles; Sánchez-Gómez, David; de María, Nuria; Díaz, Luis Manuel; Mancha, Jose A; Fernández de Simón, Brígida; Cadahía, Estrella; Desai, Nalini; Aranda, Ismael; Cervera, María-Teresa

2016-05-01

Drought is an important driver of plant survival, growth, and distribution. Water deficit affects different pathways of metabolism, depending on plant organ. While previous studies have mainly focused on the metabolic drought response of a single organ, analysis of metabolic differences between organs is essential to achieve an integrated understanding of the whole plant response. In this work, untargeted metabolic profiling was used to examine the response of roots, stems, adult and juvenile needles from Pinus pinaster Ait. full-sib individuals, subjected to a moderate and long lasting drought period. Cyclitols content showed a significant alteration, in response to drought in all organs examined, but other metabolites increased or decreased differentially depending on the analyzed organ. While a high number of flavonoids were only detected in aerial organs, an induction of the glutathione pathway was mainly detected in roots. This result may reflect different antioxidant mechanisms activated in aerial organs and roots. Metabolic changes were more remarkable in roots than in the other organs, highlighting its prominent role in the response to water stress. Significant changes in flavonoids and ascorbate metabolism were also observed between adult and juvenile needles, consistent with previously proven differential functional responses between the two developmental stages. Genetic polymorphisms in candidate genes coding for a Myb1 transcription factor and a malate dehydrogenase (EC 1.1.1.37) were associated with different concentration of phenylalanine, phenylpropanoids and malate, respectively. The results obtained will support further research on metabolites and genes potentially involved in functional mechanisms related to drought tolerance in trees. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Fisetin-Rich Extracts of Rhus verniciflua Stokes Improve Blood Flow Rates in Mice Fed Both Normal and High-Fat Diets.

Science.gov (United States)

Im, Won Kyun; Park, Hyun Jung; Lee, Kwang Soo; Lee, Jung Hoon; Kim, Young Dong; Kim, Kyeong-Hee; Park, Sang-Jae; Hong, Seokmann; Jeon, Sung Ho

2016-02-01

Although it has been previously reported that Rhus verniciflua Stokes (RVS) possesses in vitro anti-inflammatory activity, the precise in vivo mechanisms of RVS extracts and a main active component called fisetin have not been well elucidated. In this study, using newly developed protocols, we prepared urushiol-free but fisetin-enriched RVS extracts and investigated their effects on the vascular immune system. We found that the water-soluble fractions of detoxified RVS with the flavonoid fisetin can inhibit lipopolysaccharide-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2). Furthermore, RVS can reduce inducible nitric oxide synthase and COX2 gene expression levels, which are responsible for NO and PGE2 production, respectively, in RAW264.7 macrophage cells. Because inflammation is linked to the activation of the coagulation system, we hypothesized that RVS and its active component fisetin possess anticoagulatory activities. As expected, we found that both RVS and fisetin could inhibit the coagulation of human peripheral blood cells. Moreover, in vivo RVS treatment could return the retarded blood flow elicited by a high-fat diet (HFD) back to the normal level in mice. In addition, RVS treatment has significantly reduced body weight gained by HFD in mice. Taken together, the fisetin-rich RVS extracts have potential antiplatelet and antiobesity activities and could be used as a functional food ingredient to improve blood circulation.

Caracterización de algunas propiedades en tableros de corteza de Pinus pinaster Ait. y tableros de vermiculita expandida

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Pereiro López, G.

2012-06-01

Full Text Available The search for new applications to use boards requires innovation of their pro-perties. The improvement of insulation properties, the possibility to regulate the environmental conditions, the improvement of fire resistance and the increase of physical and mechanical properties allow a more diverse use of boards. Using new components in the production of boards and/or component materials also called composites (1, enables the improvement of these properties. This publication analyses different physical and mechanical properties of various types of single-layer boards produced either based on expanded vermiculite particles bonded with soluble silicate glasses (2 or based on lignocelluloses particles bark of "Pinus pinaster" Ait., agglutinated with cement derivatives of magnesium (3, the latter included in the classification of the norm (4. Commercial wood wool boards (5 are used as reference material.La búsqueda de nuevas aplicaciones en el uso de los tableros requiere de la innovación en sus propiedades. Las mejoras en el aislamiento, en la regulación de las condiciones ambientales, en su resistencia al fuego y el incremento en sus propiedades físico-mecánicas, aumentan la diversificación de sus usos. El empleo de nuevas materias en los tableros y/o en los materiales compuestos, denominados composites (1, posibilita la mejora en estas propiedades. Esta publicación analiza diversas propiedades físicas y mecánicas de varios tipos de tableros monocapa, elaborados, por un lado, a base de partículas minerales de vermiculita expandida aglutinadas con silicatos de vidrios solubles (2, y por otro lado, a base de partículas lignocelulósicas de corteza de Pinus pinaster Ait., aglutinadas con cementos derivados del magnesio (3, incluidos ya estos últimos en la clasificación de la norma (4. Como material de referencia se emplean tableros comerciales de virutas de madera (5.

Protective effect of Rhus coriaria fruit extracts against hydrogen peroxide-induced oxidative stress in muscle progenitors and zebrafish embryos

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Fadia Najjar

2017-12-01

Full Text Available Background and Purpose Oxidative stress is involved in normal and pathological functioning of skeletal muscle. Protection of myoblasts from oxidative stress may improve muscle contraction and delay aging. Here we studied the effect of R. coriaria sumac fruit extract on human myoblasts and zebrafish embryos in conditions of hydrogen peroxide-induced oxidative stress. Study Design and Methods Crude ethanolic 70% extract (CE and its fractions was obtained from sumac fruits. The composition of sumac ethyl acetate EtOAc fraction was studied by 1H NMR. The viability of human myoblasts treated with CE and the EtOAc fraction was determined by trypan blue exclusion test. Oxidative stress, cell cycle and adhesion were analyzed by flow cytometry and microscopy. Gene expression was analyzed by qPCR. Results The EtOAc fraction (IC50 2.57 µg/mL had the highest antioxidant activity and exhibited the best protective effect against hydrogen peroxide-induced oxidative stress. It also restored cell adhesion. This effect was mediated by superoxide dismutase 2 and catalase. Pre-treatment of zebrafish embryos with low concentrations of the EtOAc fraction protected them from hydrogen peroxide-induced death in vivo. 1H NMR analysis revealed the presence of gallic acid in this fraction. Conclusion Rhus coriaria extracts inhibited or slowed down the progress of skeletal muscle atrophy by decreasing oxidative stress via superoxide dismutase 2 and catalase-dependent mechanisms.

Evaluation of 6 years use of sedation with midazolam for dental treatment

DEFF Research Database (Denmark)

Østergaard, Birthe; Haukali, Gro; Poulsen, Sven

  Abstract: Titel: Evaluering af seks års brug af midazolam til sedering ved tandbehandling. B. Høgsbro Østergaard 1,2 , G. Haukali 1,2, S. Poulsen 2 . 1 Tandplejen Århus, 2 Afd. for Samfundsodontologi og Pædodonti, Århus Tandlægeskole, Århus Universitet. Mål: At evaluere midazolamsedering til...

Türkiye'nin 7 akarsu havzasında horozbina, Salaria fluviatilis (Asso,1801, balığına ait boy-ağırlık ilişkisi.

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Ali İlhan

2015-12-01

Full Text Available Bu çalışmada Türkiye‟nin 7 akarsu havzasından toplanmış olan Horozbina Balığı (Salaria fluviatilis‟na ait boy-ağırlık ilişkisinin ortaya çıkarılması amaçlanmıştır. Marmara, Küçük Menderes, Batı Karadeniz, Antalya, Doğu Akdeniz, Seyhan ve Ceyhan havzalarına ait akarsulardan toplanmış olan 652 birey incelenmiştir. Tüm bireyler dikkate alındığında türün Türkiye içsularındaki total boy dağılımı 2.0-12.9 cm, total ağırlık dağılımı 0.10-33.82 g, boy-ağırlık ilişkisi parametreleri a= 0.0135, b= 3.004, r2= 0.986 olarak hesaplanmıştır. Ayrıca, büyüme tipi havzaların 5‟inde izometrik, 1 havzada pozitif allometrik ve 1 havzada da negatif allometrik olarak belirlenmiştir

DNA-protective effects of sumach (Rhus coriaria L.), a common spice: Results of human and animal studies

Energy Technology Data Exchange (ETDEWEB)

Chakraborty, Asima; Ferk, Franziska; Simic, Tatjana [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria); Brantner, Adelheid [Institute of Pharmacognosy, University of Graz, Universitaetsplatz 4/I, A-8010 Graz (Austria); Dusinska, Maria [Center for Ecological Economics, Norwegian Institute for Air Research, Instituttveien 18, NO-2027 Kjeller (Norway); Kundi, Michael [Institute of Environmental Health, Center for Public Health, Medical Unviversity of Vienna (Austria); Hoelzl, Christine; Nersesyan, Armen [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria); Knasmueller, Siegfried [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)], E-mail: siegfried.knasmueller@meduniwien.ac.at

2009-02-10

Sumach (Rhus coriaria L.) is widely used as a spice. The aim of this study was the investigation of its DNA-protective effects in humans and animals. Prevention of the formation of strand breaks and oxidized DNA bases as well as the protection against H{sub 2}O{sub 2}- and ({+-})-anti-benzo[a]pyrene-7,8-dihydro-diol-9,10-epoxide (BPDE)-induced DNA-damage were monitored in human lymphocytes in a placebo controlled trial (N = 8/group) with ethanolic extract of sumach (3.0 g/day, 3 days) in single cell gel electrophoresis assays. Furthermore, DNA-protective effects of sumach were monitored in different inner organs of rats under identical conditions. No alteration of DNA-migration was detectable in human lymphocytes under standard conditions, but a decrease of the tail-lengths due to formation of oxidized purines and pyrimidines (52% and 36%) was found with lesion-specific enzymes. Also damage caused by H{sub 2}O{sub 2} and BPDE was significantly reduced by 30% and 69%, respectively. The later effect may be due to induction of glutathione S-transferase (GST). After the intervention, the overall GST (CDNB) activity in plasma was increased by 40%, GST-{alpha} by 52% and GST-{pi} by 26% (ELISA). The antioxidant effects of extract are probably due to scavenging which was observed in in vitro experiments, which also indicated that gallic acid is the active principle of sumach. The animal experiments showed that sumach also causes protection in inner organs. Supplementation of the drinking water (0.02 g/kg per animal) decreased the formation of oxidized DNA bases in colon, liver, lung and lymphocytes; also after {gamma}-irradiation pronounced effects were seen.

Inhibition of Human Cytochrome P450 Enzymes by Allergen Removed Rhus verniciflua Stoke Standardized Extract and Constituents

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Hyunsik Jung

2014-01-01

Full Text Available Objective. Potential interactions between herbal extracts and the cytochrome P450 (CYP system lead to serious adverse events or decreased drug efficacy. Rhus verniciflua stoke (RVS and its constituents have been reported to have various pharmacological properties. We evaluated the inhibitory potential of RVS and its constituents on the major CYP isoforms. Methods. The effects of allergen removed RVS (aRVS standardized extract and major components, fustin and fisetin isolated from aRVS, were evaluated on CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 isoenzyme activity by a luminescent CYP recombinant human enzyme assay. Results. The aRVS extract showed relative potent inhibitory effects on the CYP2C9 (IC50, <0.001 μg/mL, CYP2C19 (IC50, 9.68 μg/mL, and CYP1A2 (IC50, 10.0 μg/mL. However, it showed weak inhibition on CYP3A4 and CYP2D6. Fustin showed moderate inhibitory effects on the CYP2C19 (IC50, 64.3 μg/mL and weak inhibition of the other CYP isoforms similar to aRVS. Fisetin showed potent inhibitory effects on CYP2C9, CYP2C19, and CYP1A2. Fisetin showed moderate inhibition of CYP2D6 and weak inhibition of CYP3A4. Conclusions. These results indicate that aRVS, a clinically available herbal medicine, could contribute to herb-drug interactions when orally coadministered with drugs metabolized by CYP2C9, CYP2C19, and CYP1A2.

Inhibitory Effect of the Ethyl Acetate Fraction of Ethanol Extract from Rhus verniciflua Stokes Wood on the Activity of Mushroom Tyrosinase

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Hong Xia Chen

2014-10-01

Full Text Available Solvent extracts of Rhus verniciflua Stokes wood were made using decompressing inner ebullition, and a Box-Behnken design was used to optimize extraction conditions to produce an extract that inhibited tyrosinase activity. The chemical compositions and inhibition rates were determined in extracts made with petroleum ether, ethyl acetate, n-butanol, and an aqueous fractionation. The ethyl acetate fraction had the highest total phenolic content and inhibition rates. The main flavonoids in this fraction were 0.531% fisetin, 7.582% fustin, 0.848% sulfuretin, and 0.272% butein. The effects of the extract on the monophenolase and diphenolase activity of mushroom tyrosinase were studied using the Lineweaver-Burk equation to determine the effect of the extract on inhibition of tyrosinase activity. The results showed that the extract inhibited both the monophenolase and diphenolase activity of the enzyme. The IC50 of the ethyl acetate extract was 308 μg/mL, with the lag period of the enzyme being obviously lengthened; it was estimated to be 2.45 min in the absence of the inhibitor and extended to 9.63 min in the presence of 500 μg/mL of extract. The ethyl acetate extract acted as a mixed type inhibitor. The KI was less than the KIS, which demonstrates that the [ESI] is less stable than [EI], suggesting that the extract could easily combine with free enzyme in the enzyme catalysis system, thus affecting enzyme catalysis on the substrate.

Efeito do controle do sob coberto e da fertilização no cresci­mento e concentração de nutrientes em pinheiro bravo (Pinus pinaster Ait. Effect of controlling competing vegetation and fertilization on maritime pine (Pinus pinaster Ait. growth and nutrient concentration

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R. Xavier

2010-01-01

Full Text Available Para determinar o interesse do controle da vegetação do sob coberto e da aplicação de N, P e K no crescimento e concentração de nutrientes em pinheiro bravo (Pinus pinas­ter Ait. escolheu-se um pinhal com seis anos onde, em Julho de 2002, foram aplica­dos cinco tratamentos: testemunha (T; corte e remoção da vegetação (CR; corte, remo­ção da vegetação e fertilização (CRF; corte e destroçamento da vegetação (CD; corte, destroçamento da vegetação e fertilização (CDF. Entre 2002 e 2007, e em relação a todos os parâmetros dendrométricos considerados, altura, diâmetro, área basal e volume, verifi­cou-se que os acréscimos ocorridos no tra­tamento CDF foram superiores (pTo study the interest of controlling the understory vegetation and the addition of N, P and K on the growth and nutrient concen­tration in maritime pine (Pinus pinaster Ait., a field trial was established in a 6-year old pine forest. Five treatments were tested: control (T; cutting and removal of compet­ing vegetation (CR; cutting, removal of competing vegetation and fertilization (CRF; cutting and chipping of competing vegetation (CD; cutting, chipping of com­peting vegetation and fertilization (CDF. Between 2002 and 2007, growth in the CDF treatment was higher (p <0.05 than in the other treatments. The lowest growth oc­curred in control and/or in the CR treatment. In general, there were no differences between CD and CRF treatments. Therefore, these re­sults point out that removal of competing vegetation should be considered only if fertil­izers are added (CRF treatment in order to avoid negative effects on pine growth. Ap­plying fertilizers increased N, P and K con­centrations only in 2002 and 2003, although the increase was not significant.

Integration of the ATHENA mirror modules: development of indirect and x-ray direct AIT methods

Science.gov (United States)

Vernani, Dervis; Blum, Steffen; Seure, Thibault; Bavdaz, Marcos; Wille, Eric; Schaeffer, Uwe; Lièvre, Nicolas; Nazeeruddin, Adeeb; Barrière, Nicolas M.; Collon, Maximilien J.; Cibik, Levent; Krumrey, Michael; Müller, Peter; Burwitz, Vadim

2017-08-01

Within the ATHENA optics technology plan, activities are on-going for demonstrating the feasibility of the mirror module Assembly Integration and Testing (AIT). Each mirror module has to be accurately attached to the mirror structure by means of three isostatic mounts ensuring minimal distortion under environmental loads. This work reports on the status of one of the two parallel activities initiated by ESA to address this demanding task. In this study awarded to the industrial consortium, the integration relies on opto-mechanical metrology and direct X-ray alignment. For the first or "indirect" method the X-ray alignment results are accurately referenced, by means of a laser tracking system, to optical fiducial targets mounted on the mirror modules and finally linked to the mirror structure coordinate system. With the second or "direct" method the alignment is monitored in the X-ray domain, providing figures of merit directly comparable to the final performance. The integration being designed and here presented, foresees combining the indirect method to the X-ray direct method. The characterization of the single mirror modules is planned at PTB's X-ray Parallel Beam Facility (XPBF 2.0) at BESSY II, and the integration and testing campaign at Panter. It is foreseen to integrate and test a demonstrator with two real mirror modules manufactured by cosine.

Research on the antioxidant, wound healing, and anti-inflammatory activities and the phytochemical composition of maritime pine (Pinus pinaster Ait).

Science.gov (United States)

Tümen, İbrahim; Akkol, Esra Küpeli; Taştan, Hakkı; Süntar, Ipek; Kurtca, Mehmet

2018-01-30

Ethnobotanical investigations have shown that the Pinus species have been used against rheumatic pain and for wound healing in Turkish folk medicine. In this study, phytochemical composition, antioxidant, anti-inflammatory, and wound healing activities of Maritime Pine (Pinus pinaster Ait.) that is collected in Turkey are investigated. Essential oil composition and the amount of extracts (lipophilic and hydrophilic) of maritime pine wood and fresh cone samples had been tested. The essential oil from cones of P. pinaster revealed the highest activities, whereas other parts of the plant did not display any appreciable wound healing, anti-inflammatory, or antioxidant effects. α-Pinene was the main constituent of the essential oil obtained from the cones of P. pinaster. Experimental studies shown that P. pinaster's remarkable anti-inflammatory and wound healing activities support the traditional use of the plant, and suggest it could have a place in modern medicine. Copyright © 2017 Elsevier B.V. All rights reserved.

Appraisal of phytochemical and in vitro biological attributes of an unexplored folklore: Rhus Punjabensis Stewart.

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Tabassum, Saira; Ahmed, Madiha; Mirza, Bushra; Naeem, Muhammad; Zia, Muhammad; Shanwari, Zabta Khan; Khan, Gul Majid

2017-03-09

The role of plants for discovery of therapeutic potential accentuates the need to know their biological attributes. The present study aims to comprehend the biological attributes of Rhus punjabensis, an unexplored traditional medicinal plant. Leaf and stem extracts of R. punjabensis prepared in 11 different organic solvents are evaluated for multimode antioxidant potential, total phenolic and flavonoid contents were determined through colorimetric assays, HPLC-DAD analysis was carried out for quantification of various polyphenols in extracts. Brine shrimp lethality, SRB and MTT assays were used to elucidate plant's cytotoxic and antileishmanial potentials. Disc diffusion assay was used to elucidate the protein kinase inhibitory, antibacterial and antifungal spectrum. Ethanol + ethyl acetate yielded maximum extract recovery from leaf (6.11 ± 1.09% w/w), total phenolic content (80.5 ± 2.18 μg GAE/mg extract) and reducing power potential (165.4 ± 2.29 μg AAE/mg extract). Maximum flavonoid content (30.50 ± 1.11 μg QE/mg extract) and highest DPPH based free radical scavenging activity (IC 50 11.4 ± 2.07) was exhibited by the methanol + chloroform leaf extract. The methanol extract showed maximum total antioxidant capacity (74.5 ± 2.25 μg AAE/mg DW), protein kinase inhibitory (12.5 ± 1.10 bald phenotype at 100 μg/disc) and antifungal (MIC = 25 μg/disc against Aspergillus flavus) potential. Reverse phase HPLC-DAD based quantification reveals presence of gallic acid, apigenin, rutin and catechin in various extracts. Brine shrimp lethality assay demonstrated most extracts as highly cytotoxic (LC 50  < 50 μg/mL) whereas chloroform extract of leaf demonstrated maximuminhibition against human leukemia cell line (IC 50 7.80 ± 0.01 μg/mL). A significant activity against leishmanial promastigotes was demonstrated by n-hexane leaf extract (IC 50  = 15.78 ± 0.15 μg/mL). A better antibacterial

Preliminary investigations of the digestive processes of the white ...

African Journals Online (AJOL)

Asparagus africanus. Elitropappus rhinoceratus. Shrubs. Grewia robusta. Portulacaria afra. Diospyros dichrophyl/a. Rhigozum obovatum. Lycium campanulatum. Hypoesta verticil/ata. Rhus sp. Scutia myrtina. Fruits and seeds. May tenus capitata. Asparagus africanus. Grewia robusta. Acacia karoo. Scutia myrtina. Rhus sp.

Incidence of pests and viral disease on pepino (Solanum muricatum Ait.) in Kanagawa Prefecture, Japan.

Science.gov (United States)

Kim, Ok-Kyung; Ishikawa, Tadashi; Yamada, Yoshihiro; Sato, Takuma; Shinohara, Hirosuke; Takahata, Ken

2017-01-01

The solanaceous fruit crop pepino ( Solanum muricatum Ait.), originating in the Andes, is grown commercially in South American countries and New Zealand. In these areas, pests and diseases of pepino have been identified well; however, to date, these have seldom been investigated in detail in Japan. Herein, we attempt to reconstruct an agricultural production system for commercial pepino crops in Japan, and evaluate the incidence of pests and viral diseases on pepino. The findings of this study will facilitate in developing a better crop system for the commercial cultivation of healthy pepino fruits. A total of 11 species, comprising nine insects and two mites, were recognized as pests of pepino plants in our experimental fields in Kanagawa Prefecture, central Honshu, Japan. Of these pest species, the two-spotted spider mite Tetranychus urticae Koch, 1836 and the cotton aphid Aphis gossypii Glover, 1877, were remarkably abundant than the other pest species. Eventually, 13 species, including two previously recorded, are currently recognized as the pests of pepino in Japan. With regard to viruses, we tested two species Alfalfa mosaic virus (AMV) and Cucumber mosaic virus (CMV), as well as three genera Carlavirus , Potexvirus , and Potyvirus . No virus was detected in symptomatic pepino leaves collected in our experimental fields. This is a first report on the identification of pests on pepino plants in Kanagawa Prefecture, Japan and elucidates the relationship between currently occurring pests of pepino plants and potential viral pathogens that they can transmit.

Preliminary investigations of the digestive processes of the white ...

African Journals Online (AJOL)

Portulacaria afra. Diospyros dichrophyl/a. Rhigozum obovatum. Lycium campanulatum. Hypoesta verticil/ata. Rhus sp. Scutia myrtina. Fruits and seeds. May tenus capitata. Asparagus africanus. Grewia robusta. Acacia karoo. Scutia myrtina. Rhus sp. Insects. Tenebrionid beetles. Tenebrio molitor. Mimorista pulchel/alis.

Hepatoprotective and antioxidant activity of Phaseolus trilobus, Ait on bile duct ligation induced liver fibrosis in rats.

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Fursule, R A; Patil, S D

2010-06-16

Phaseolus trilobus Ait (Fabaceae) is extensively used by tribal people of Nandurbar district (Maharashtra, India) in the treatment of Jaundice and other liver disorders. of the present study was to assess the medicinal claim of Phaseolus trilobus as hepatoprotective and antioxidant. The hepatoprotective activity of methanol and aqueous extract of Phaseolus trilobus was evaluated by bile duct ligation induced liver fibrosis and antioxidant activity was evaluated using in vitro and in vivo antioxidant models viz anti-lipid peroxidation assay, super oxide radical scavenging assay and glutathione estimation in liver. Liver function tests were carried out to detect hepatoprotective activity, which was further supported by histopathological examination. Methanol and aqueous extracts of Phaseolus trilobus reduced elevated level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and hydroxyproline significantly (pWistar rats, proving hepatoprotective activity comparable with Silymarin. Both the extracts were found to reduce the elevated levels of serum thiobarbituric acid reactive substance (TBARS) and elevate superoxide scavenging radical activity proving antioxidant activity comparable with ascorbic acid. The reduced level of glutathione was found to be elevated in liver proving antioxidant activity comparable with Silymarin. Phaseolus trilobus posses hepatoprotective property and is effective in oxidative stress induced cholestatic hepatic injury. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

Inequidad en la distribución de recursos humanos en los establecimientos del Ministerio de Salud de cuatro regiones del Perú

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Betsy Moscoso Rojas

2015-01-01

Full Text Available Introducción: La densidad de Recursos Humanos en Salud (RHUS a nivel nacional en Perú, ha superado el umbral establecido por la OMS (25 por 10 000 habitantes para garantizar la cobertura de servicios de Salud. Sin embargo, este promedio nacional enmascara, a nivel regional, densidades inferiores al umbral estipulado, particularmente en las zonas más pobres del país. De ahí la necesidad de estudiar la posible existencia de inequidades en la distribución de RHUS a nivel regional, entendiendo a la inequidad como la innecesaria, evitable e injustificada carencia de RHUS. Objetivos: Determinar la inequidad en la distribución del personal de salud en los establecimientos de salud del Ministerio de Salud de cuatro regiones pobres del Perú (Cajamarca, Loreto, Apurímac y San Martín. Diseño: Estudio observacional descriptivo, de corte transversal. Institución: Dirección General de Gestión del Desarrollo de Recursos Humanos. Métodos: Se calculó la densidad de RHUS para cada región. Para la evaluación de la inequidad se calcularon los índices Gini, para el nivel departamental, y la T de Theil, para el nivel provincial. Resultados: La densidad de recursos humanos estuvo por debajo de mínimo estipulado por la OMS en 3 de las 4 regiones estudiadas. Los índices de Gini encontrados fueron 0,175 (Cajamarca, 0,157 (Loreto, 0,372 (Apurímac, y 0,146 (San Martín, que indican una tendencia a la equidad. En tanto, en el análisis intrarregional, los índices T de Theil muestran que un número importante de provincias tienen una buena distribución de RHUS. Conclusiones: A pesar de encontrar una baja densidad de RHUS en la mayoría de las regiones estudiadas, la distribución de los RHUS entre cada región muestra una tendencia hacia la equidad.

The role of arginine metabolic pathway during embryogenesis and germination in maritime pine (Pinus pinaster Ait.).

Science.gov (United States)

Llebrés, María-Teresa; Pascual, María-Belén; Debille, Sandrine; Trontin, Jean-François; Harvengt, Luc; Avila, Concepción; Cánovas, Francisco M

2018-03-01

Vegetative propagation through somatic embryogenesis is critical in conifer biotechnology towards multivarietal forestry that uses elite varieties to cope with environmental and socio-economic issues. An important and still sub-optimal process during in vitro maturation of somatic embryos (SE) is the biosynthesis and deposition of storage proteins, which are rich in amino acids with high nitrogen (N) content, such as arginine. Mobilization of these N-rich proteins is essential for the germination and production of vigorous somatic seedlings. Somatic embryos accumulate lower levels of N reserves than zygotic embryos (ZE) at a similar stage of development. To understand the molecular basis for this difference, the arginine metabolic pathway has been characterized in maritime pine (Pinus pinaster Ait.). The genes involved in arginine metabolism have been identified and GFP-fusion constructs were used to locate the enzymes in different cellular compartments and clarify their metabolic roles during embryogenesis and germination. Analysis of gene expression during somatic embryo maturation revealed high levels of transcripts for genes involved in the biosynthesis and metabolic utilization of arginine. By contrast, enhanced expression levels were only observed during the last stages of maturation and germination of ZE, consistent with the adequate accumulation and mobilization of protein reserves. These results suggest that arginine metabolism is unbalanced in SE (simultaneous biosynthesis and degradation of arginine) and could explain the lower accumulation of storage proteins observed during the late stages of somatic embryogenesis.

Interview about summer school Deaf Studies

DEFF Research Database (Denmark)

2015-01-01

Fra den 13. til den 17. juli var der sommerskole på Århus Universitet. Døvestudier var på skemaet med særlig fokus på ligestilling og identitet. Arrangementet var et samarbejde mellem Danske Døves Landsforbund og Århus Universitet. Varighed 8:37 min...

Growdon Gate/Road Relocation and Property Acquisition Environmental Assessment. Volume 1

Science.gov (United States)

2012-11-01

black walnut (Juglans nigra), pecan ( Carya illinoensis ), blackberry (Rubus sp.), greenbriar (Smilax sp.), poison ivy (Rhus radicans), giant...Riparian Cedar elm (Ulmus crassifolia), black willow (Salix nigra), hackberry (Celtis laevigata), chinaberry (Melia azedarach), pecan ( Carya ... illinoensis ), Canada wildrye (Elymus candensis), poison ivy (Rhus radicans), greenbrier (Smilax spp.), and giant ragweed (Ambrosia trifida) Urban

Biochemical composition and germination capacity of Ligustrum lucidum ait. seeds in the process of biological invasion=Composição bioquímica e capacidade de germinação de sementes de Ligustrum lucidum ait. no processo de invasão biológica

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Michelle Melissa Althaus-Ottmann

2012-07-01

Full Text Available Ligustrum lucidum ait. is an exotic species and In the present study, contents of sugars, proteins, and germination were evaluated in seeds removed from not abscisic and abscisic fruits. The seeds were stored or not under shadow or sun. The higher contents of total and reducing sugars were observed in seeds removed from not abscisic fruit while the period of storage resulted in the loss of these compounds. The same result was observed in the content of total sugars of seeds from abscisic fruits. The content of reducing sugars in seeds from abscisic fruits and submitted to storage had its content increased. The contents of total proteins in seeds from abscisic and not abscisic submitted to shadow or sun were not significantly different, but the results suggested an increase in protein synthesis during the storage period, differently from those seeds that were not submitted to storage. When seeds from abscisic and not abscisic fruits were evaluated immediately after harvest, they presented greater percentages of germination, while after 28 days, seeds submitted to the storage treatments showed lower values. The invasive potential of L. lucidum seems to be more associated to the number of seeds produced, than to their germination potential. Ligustrum lucidum ait. é uma espécie exótica e no presente trabalho foram avaliados os teores de açúcares totais, redutores, proteínas, e germinação de sementes retiradas de frutos coletados da planta-mãe (não abscisados e dispersos (abscisados mantidos ou não em condições de sombra ou sol. Os maiores teores de açúcares totais e redutores foram obtidos em sementes imaturas, enquanto o armazenamento levou à perda destes composto, o que foi observado também para açúcares totais, nas mesmas condições, para sementes maduras. Verificaram-se aumentos nos teores de açúcares redutores em sementes maduras armazenadas. Apesar de não serem estatisticamente significativos, estes resultados entre

FlorNExT®, a cloud computing application to estimate growth and yield of maritime pine (Pinus pinaster Ait.) stands in Northeastern Portugal

Energy Technology Data Exchange (ETDEWEB)

Barreiro, S.; Rua, J.; Tomé, M.

2016-07-01

Aim of the study. To introduce and describe FlorNExT®, a free cloud computing application to estimate growth and yield of maritime pine (Pinus pinaster Ait.) even-aged stands in the Northeast of Portugal (NE Portugal). Area of study: NE Portugal. Material and methods: FlorNExT® implements a dynamic growth and yield modelling framework which integrates transition functions for dominant height (site index curves) and basal area, as well as output functions for tree and stand volume, biomass, and carbon content. Main results: FlorNExT® is freely available from any device with an Internet connection at: http://flornext.esa.ipb.pt/. Research highlights: This application has been designed to make it possible for any stakeholder to easily estimate standing volume, biomass, and carbon content in maritime pine stands from stand data, as well as to estimate growth and yield based on four stand variables: age, density, dominant height, and basal area. FlorNExT® allows planning thinning treatments. FlorNExT® is a fundamental tool to support forest mobilization at local and regional scales in NE Portugal. (Author)

Fitochemistry evaluation of leaves of Excoecaria lucida Sw. (Aité) (Euphorbiaceae) and isolation e identification of a hemiterpenoid

International Nuclear Information System (INIS)

Pacheco, Ania Ochoa; Arranz, Julio César Escalona; Fechine Tavares, Josean; Da Silva, Marcelo Sobra

2015-01-01

Introduction: excoecaria lucida Sw. (Aité), it is a species that grow in Cuba and at the Caribbean region. It has been scientifically quite a little studied, in spite of the fact that the population utilizes it due to their medicinal properties as antiasthmatic, antimicrobial, and for the toothache treatment. Objectives: to determine the chemical composition of leaves, as well as the isolation and identification of their secondary metabolites. Methods: dried and milled leaves were macerated 72 hours with ethanol 95 %, repeating the procedure in 4 occasions. Total extract was determined in his chemical qualitative composition and afterwards it was fragmented with solvents. The phase with greater yield was studied by High Performance Liquid Chromatography and isolated the main substance, which was characterized by infrared and Nuclear Magnetic Resonance spectroscopy: uni-dimensional 1H and 13C at 500 MHz and bi-dimensional HMQC, HMBC, COSY and NOESY. Results: the identification of Alkaloids, triterpenes and steroids, quinone, flavonoids, coumarins, sesqiterpenic lactones, tannins and phenols were accomplished. From the greater yield phase (butanol= 23.48 g) was isolated and identified the main compound, a hemiterpenoid. Conclusions: the identified secondary metabolites are in coincidence with other reports related to the genera. For first time the hemiterpene (2E)-2-methyl-2- buten-1,4-di-hydroxyl-1-O-β-D-glucopyranoside is informed in this genera and specie. (author)

Effects of a triplex mixture of Peganum harmala, Rhus coriaria, and Urtica dioica aqueous extracts on metabolic and histological parameters in diabetic rats.

Science.gov (United States)

Abedi Gaballu, Fereydoon; Abedi Gaballu, Yousef; Moazenzade Khyavy, Omid; Mardomi, Alireza; Ghahremanzadeh, Kazem; Shokouhi, Behrooz; Mamandy, Himan

2015-08-01

Several therapeutic effects such as antioxidant and blood glucose-lowering activities have been reported for Peganum harmala L (Zygophyllaceae) (PH) seeds, Rhus coriaria L (Anacardiaceae) (RC) fruits, and Urtica dioica L (Urticaceae) (UD) leaves. This study investigates the effects of a triplex mixture (1:1:1) of these medicinal plants on metabolic and histological parameters in diabetic rats. Aqueous extracts of PH, RC and UD were administered as either monotherapy or in combination at a final dose of 200 mg/kg to alloxan-induced diabetic rats by daily gavage. Biochemical parameters including blood glucose, liver function-related enzymes, lipid profile, and creatinine were estimated by spectrophotometric methods. Tissues from the liver and kidney stained with hematoxylin/eosin were histologically examined. The results obtained from the exposure groups were compared to either healthy or diabetic control groups. Compared with the diabetic control rats, all aqueous extracts (ED50 = 11.5 ± 2.57 mg/ml) led to significant decreases in the levels of ALP (1.39-2.23-fold, p < 0.05), low-density lipoprotein cholesterol (LDL-C) (1.79-3.26-fold, p < 0.05), and blood glucose (1.27-4.16-fold, p < 0.05). The serum concentrations of TG was decreased only by treatment with UD and triplex mixture (1.25- and 1.20-fold, respectively, p < 0.05). Among the studied parameters, alanine aminotransferase (ALT), LDL-C, TG, and creatinine recovered to healthy control levels after 4 weeks of treatment with the extract mixture. This study showed that PH, RC, and UD extracts, especially their combination, had significant antidiabetic, hypolipidemic, and liver and renal damage recovering effects.

Expanded Enlistment Eligibility Metrics (EEEM): Recommendations on a Non-Cognitive Screen for New Soldier Selection

Science.gov (United States)

2010-07-01

databases: (a) graduation from AIT/OSUT; (b) number of times recycled through AIT/OSUT; and (c) average AIT/OSUT exam grade. MOS-Specific Job...from these databases: (a) graduation from AIT/OSUT, (b) number of times recycled through AIT/OSUT, and (c) average AIT/OSUT exam grade. Predictor...ambitious, confident, or resourceful. Conscientiousness Curiosity Individuals scoring high might be characterized as inquisitive and perceptive; they

Comparative analysis of procoagulant and fibrinogenolytic activity of crude protease fractions of turmeric species.

Science.gov (United States)

Shivalingu, B R; Vivek, H K; Nafeesa, Zohara; Priya, B S; Swamy, S Nanjunda

2015-08-22

Turmeric rhizome is a traditional herbal medicine, which has been widely used as a remedy to stop bleeding on fresh cuts and for wound healing by the rural and tribal population of India. To validate scientific and therapeutic application of turmeric rhizomes to stop bleeding on fresh cuts and its role in wound healing process. The water extracts of thoroughly scrubbed and washed turmeric rhizomes viz., Curcuma aromatica Salisb., Curcuma longa L., Curcuma caesia Roxb., Curcuma amada Roxb. and Curcuma zedoria (Christm.) Roscoe. were subjected to salting out and dialysis. The dialyzed crude enzyme fractions (CEFs) were assessed for proteolytic activity using casein as substrate and were also confirmed by caseinolytic zymography. Its coagulant activity and fibrinogenolytic activity were assessed using human citrated plasma and fibrinogen, respectively. The type of protease(s) in CEFs was confirmed by inhibition studies using specific protease inhibitors. The CEFs of C. aromatica, C. longa and C. caesia showed 1.89, 1.21 and 1.07 folds higher proteolytic activity, respectively, compared to papain. In contrast to these, C. amada and C. zedoria exhibited moderate proteolytic activity. CEFs showed low proteolytic activities compared to trypsin. The proteolytic activities of CEFs were confirmed by caseinolytic zymography. The CEFs of C. aromatica, C. longa and C. caesia showed complete hydrolysis of Aα, Bβ and γ subunits of human fibrinogen, while C. amada and C. zedoria showed partial hydrolysis. The CEFs viz., C. aromatica, C. longa, C. caesia, C. amada and C. zedoria exhibited strong procoagulant activity by reducing the human plasma clotting time from 172s (Control) to 66s, 84s 88s, 78s and 90s, respectively. The proteolytic activity of C. aromatica, C. longa, C. caesia and C. amada was inhibited (>82%) by PMSF, suggesting the possible presence of a serine protease(s). However, C. zedoria showed significant inhibition (60%) against IAA and moderate inhibition (30

Characterization of juvenile maritime pine (Pinus pinaster Ait.) ectomycorrhizal fungal community using morphotyping, direct sequencing and fruitbodies sampling.

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Pestaña Nieto, Montserrat; Santolamazza Carbone, Serena

2009-02-01

Using ectomycorrhizal root tip morphotyping (anatomical and morphological identification), molecular analysis (internal transcribed spacer region amplification and sequencing), and fruitbody sampling, we assessed diversity and composition of the ectomycorrhizal fungal community colonizing juvenile Pinus pinaster Ait. under natural conditions in NW Spain. Overall, we found 15 Basidiomycetes and two Ascomycetes. Members of the family Thelephoraceae represented up to 59.4% of the samples. The most frequent species was Tomentella sublilacina followed by Thelephora terrestris, Russula drimeia, Suillus bovinus, and Paxillus involutus, while the less frequent were Pseudotomentella tristis, Lactarius subdulcis, Russula ochroleuca, and Entoloma conferendum. From October 2007 to June 2008, we sampled 208 sporocarps belonging to seven genera and nine species: Thelephora terrestris, Paxillus involutus, Suillus bovinus, Xerocomus badius, Scleroderma verrucosum, Amanita gemmata, A. rubescens, Amanita sp., and Russula sp. The species belonging to the genus Amanita, X. badius and S. verrucosum were not found on root samples. By comparing our results with a bibliographic review of papers published from 1922 to 2006, we found five genera and six species which have not been previously reported in symbiosis with P. pinaster. This is the first time that the diversity of the ectomycorrhizal fungal community associated with P. pinaster was investigated using molecular techniques. Considering that only 38% of the genera found by sequencing were found as fruitbodies, we conclude that integrating morphotyping and sporocarps surveys with molecular analysis of ectomycorrhizas is important to documenting the ectomycorrhizal fungus community.

Effects of hydroalcoholic extract of Rhus coriaria seed on glucose and insulin related biomarkers, lipid profile, and hepatic enzymes in nicotinamide-streptozotocin-induced type II diabetic male mice.

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Ahangarpour, Akram; Heidari, Hamid; Junghani, Majid Salehizade; Absari, Reza; Khoogar, Mehdi; Ghaedi, Ehsan

2017-10-01

Type 2 diabetes often leads to dislipidemia and abnormal activity of hepatic enzymes. The purpose of this study was to evaluate the antidiabetic and hypolipidemic properties of Rhus coriaria ( R. coriaria ) seed extrac on nicotinamide-streptozotocin induced type 2 diabetic mice. In this experimental study, 56 male Naval Medical Research Institute mice (30-35 g) were randomly separated into seven groups: control, diabetic group, diabetic mice treated with glibenclamide (0.25 mg/kg, as standard antidiabetic drug) or R. coriaria seed extract in doses of 200 and 300 mg/kg, and control groups received these two doses of extract orally for 28 days. Induction of diabetes was done by intraperitoneal injection of nicotinamide and streptozotocin. Ultimately, body weight of mice, blood levels of glucose, insulin, hepatic enzymes, leptin, and lipid profile were assayed. After induction of type 2 diabetes, level of glucose, cholesterol, low density lipoprotein, serum glutamic oxaloacetic transaminase, and serum glutamic pyruvic transaminase increased and level of insulin and high density lipoprotein decreased remarkably. Administration of both doses of extract decreased level of glucose and cholesterol significantly in diabetic mice. LDL level decreased in treated group with dose of 300 mg/kg of the extract. Although usage of the extract improved level of other lipid profiles, insulin and hepatic enzymes, changes weren't significant. This study showed R. coriaria seeds administration has a favorable effect in controlling some blood parameters in type 2 diabetes. Therefore it may be beneficial in the treatment of diabetes.

Aktivitas minyak dan serbuk enam spesies tumbuhan terhadap peneluran dan Mortalitas Callosobruchus sp. (Coleoptera: Bruchidae

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Dadang Dadang

2017-02-01

Full Text Available Storage pests remain one of the main problems in storage. The pest attacks occur not only in the field, but also in storage. Control should be done to maintain the quality of storedproducts. The environmentally friendly measures should be implemented to avoid negative impacts to the environment and human being. The objective of this research was to study the mortality and oviposition deterrence caused by powder and oil of six plant species against Callosobruchus sp. (Coleoptera: Bruchidae. Flowers of Eugenia aromatica, roots of Vetiveria zizanioides, leaves of Pogostemon cablin, seeds of Ricinus communis, seeds of Foeniculum vulgare, and stems of Cymbopogon citratus were air-dried and milled to yield powder. Oil of six plant species were purchased from local market. Oviposition deterrent bioassay was conducted by no-choice method for both powder and oil, while mortality bioassay was conducted by topical application and residual methods for plant oil only. Several plant species showed high biological activity to Callosobruchus sp. Powder of E. aromatica and oil of V. zizanioides caused high oviposition deterrence, while oil of V. zizanioides and E. aromatica caused high mortality.

2018 European Thyroid Association (ETA) Guidelines for the Management of Amiodarone-Associated Thyroid Dysfunction.

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Bartalena, Luigi; Bogazzi, Fausto; Chiovato, Luca; Hubalewska-Dydejczyk, Alicja; Links, Thera P; Vanderpump, Mark

2018-03-01

Treatment with amiodarone is associated with changes in thyroid function tests, but also with thyroid dysfunction (amiodarone-induced hypothyroidism, AIH, and amiodarone-induced thyrotoxicosis, AIT). Both AIH and AIT may develop in apparently normal thyroid glands or in the presence of underlying thyroid abnormalities. AIH does not require amiodarone withdrawal, and is treated with levothyroxine replacement if overt, whereas subclinical forms may be followed without treatment. Two main types of AIT are recognized: type 1 AIT (AIT 1), a form of iodine-induced hyperthyroidism occurring in nodular goitres or latent Graves disease, and type 2 AIT (AIT 2), resulting from destructive thyroiditis in a normal thyroid gland. Mixed/indefinite forms exist due to both pathogenic mechanisms. AIT 1 is best treated with thionamides that may be combined for a few weeks with sodium perchlorate to make the thyroid gland more sensitive to thionamides. AIT 2 is treated with oral glucocorticoids. Once euthyroidism has been restored, AIT 2 patients are followed up without treatment, whereas AIT 1 patients should be treated with thyroidectomy or radioiodine. Mixed/indefinite forms of AIT are treated with thionamides. Oral glucocorticoids can be added from the beginning if a precise diagnosis is uncertain, or after a few weeks if response to thionamides alone is poor. The decision to continue or to stop amiodarone in AIT should be individualized in relation to cardiovascular risk stratification and taken jointly by specialist cardiologists and endocrinologists. In the presence of rapidly deteriorating cardiac conditions, emergency thyroidectomy may be required for all forms of AIT.

FlorNExT®, a cloud computing application to estimate growth and yield of maritime pine (Pinus pinaster Ait. stands in Northeastern Portugal

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Fernando Pérez-Rodríguez

2016-07-01

Full Text Available Aim of the study: To introduce and describe FlorNExT®, a free cloud computing application to estimate growth and yield of maritime pine (Pinus pinaster Ait. even-aged stands in the Northeast of Portugal (NE Portugal. Area of study: NE Portugal. Material and methods: FlorNExT® implements a dynamic growth and yield modelling framework which integrates transition functions for dominant height (site index curves and basal area, as well as output functions for tree and stand volume, biomass, and carbon content. Main results: FlorNExT® is freely available from any device with an Internet connection at: http://flornext.esa.ipb.pt/. Research highlights: This application has been designed to make it possible for any stakeholder to easily estimate standing volume, biomass, and carbon content in maritime pine stands from stand data, as well as to estimate growth and yield based on four stand variables: age, density, dominant height, and basal area. FlorNExT® allows planning thinning treatments. FlorNExT® is a fundamental tool to support forest mobilization at local and regional scales in NE Portugal. Keywords: forest management; maritime pine; forest modelling; knowledge transfer tool.

Estudio de la composición química de las semillas y aceites seminales de Ligustrum lucidum Ait y Ligustrum sinense Lour

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Nolasco, S. M.

2001-02-01

Full Text Available The fruits of Ligustrum lucidum Ait and Ligustrum sinense Lour were harvested in Olavarria (Province of Buenos Aires, Argentine. The seeds and extracted oils were analysed for characteristics and composition. The seed contained 8,7-10 and 10,7 % (dry basis, respectively. The physicochemical characteristics of the crude oils were: refractive index 1,4647 and 1,4640 (at 25ºC, iodine value 93,7 and 88,8, saponification index 167 and 154, unsaponifiable matter 11 and 18 %, and free fatty acid content of 4,8 and 9,2 (mg KOH/g, respectively. Gas chromatographic analysis of the oils revealed high levels of oleic acid (57,8 and 51,10%, about 25,1 and 29,6 % of saturated acids, respectively, most of them consisting of palmitic acid, but they have a significant content of acid of more than 18 atoms of carbon. The residual seed meals contained low level of crude protein and of available lysine (2.45, 3.65, g/16g N, respectively. Total and phytic acid phosphorous, calcium, ash, crude fiber, and polysaccharides (non presence of starch contents are reported.Frutos de Ligustrum lucidum Ait y Ligustrum sinense Lour fueron cosechados en Olavarría (provincia de Buenos Aires, Argentina y sus semillas separadas en forma manual. Las semillas se agotaron con n-hexano, obteniendo los aceites crudos con rendimientos del 8,7-10% y 10,7 % (base seca, respectivamente. Los aceites crudos se examinaron en sus características fisicoquímicas (Índice de refracción: 1,4647 y 1,4640 (a 25ºC, Indice de iodo: 93,7 y 88,8, Indice de saponificación: 167 y 154, insaponificable: 11 y 18 %, Indice de acidez: 4,8 y 9,2 (mgKOH/g respectivamente. El análisis por cromatografía gaseosa de los ésteres metílicos reveló alto porcentaje de ácido oleico (57,8 y 51,1%, alrededor de un 25,1 y 29,6 % de ácidos saturados, respectivamente, predominando el ácido palmítico, pero con un significativo contenido de ácidos de más de 18 átomos de carbono. Las harinas residuales de

The invasion and expansion of three North American species of goldenrod (Solidago canadensis L. sensu lato. S. gigantea Ait. and S. graminifolia (L Salisb in Poland

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Małgorzata Guzikowa

2014-01-01

Full Text Available The geographical distributions of three adventive species of North American goldenrods (S. canadensis L. s.l., S. gigantea Ait. and S. graminifolin (L. Salisb. throughout Poland are presented. The history of escape, initial establishent and subsequent spread are documented on the basis of almost 1400 herbarium collections and site records of the authors. Of the three species S. gigantea is the most aggressive S. cunadensis has continued to spread vigorously. but S. graminifolia has barely moved beyond its initial area of establishment. The first two species occur essentially throughout Poland. having expanded from centers in southwestern Poland in the decade between 1840 to 1850. Both of these plants are spreading rapidly and producing vigorous populations which thrive in disturbed and semi-disturbed environments and S. gigantea seems to have now attained the capability of invading stabilized habitats and communities. They are in the process of becoming a serious threat to many natural environments and ecosystems in Poland.

Influence of sumac (Rhus Coriaria L.) and ginger (Zingiber officinale) on egg yolk fatty acid, cholesterol and blood parameters in laying hens.

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Gurbuz, Y; Salih, Y G

2017-12-01

The aim of the study was to evaluate the potential effect of different levels of sumac (Rhus coriaria L.) seed powder and ginger (Zingiber officinale) root powder on egg yolk fatty acid composition, blood/yolk cholesterol in laying hen. A total of 63 (ATAK-S: Domestic Turkish Laying Hens) laying hens (average weight: 1470 g each hen, 25-weeks of age) were assigned to seven treatment diets including sumac seed (S) and ginger root powder (G) at 0 g/kg (control), 10 g/kg (S1), 20 g/kg (S2), and 30 g/kg (S3); 10 g/kg (G1), 20 g/kg (G2), or 30 g/kg in rations respectively, for 8 weeks. After a two-week adaptation period to cages, the hens were allocated to 7 groups with 9 replicates of 1 hen in per cage each. The replications were allotted equally into the upper and lower cages to minimize the effects of cage level. In this study, egg yolk cholesterol had a decrease (p <0.05) in supplemented diet( sumac seed and ginger root powder). Fatty acid content in yolk; saturated fatty acid, monounsaturated fatty acids, polyunsaturated fatty acids and rate of n6/n3 were not significant (p <0.05). However, dietary supplementation with sumac and ginger powder reduced and yolk/blood cholesterol concentrations in laying hens. Supplementation of sumac and ginger affected on HDL, there was found a significant effect (p < 0.05) in treatment groups. Moreover, LDL positively decreased in all treatment groups compared with the control group. The findings of this study suggested that feeding sumac and ginger tend to be decreasing cholesterol levels in both yolk and blood on laying hens. It can be concluded that ginger root and sumac seed powder can be used as an effective feed additive to improve fatty acid composition and yolk and blood cholesterol in ATAK-S laying hens. Journal of Animal Physiology and Animal Nutrition © 2017 Blackwell Verlag GmbH.

Propagação vegetativa de Platanus acerifolia Ait: (II efeito da aplicação de zinco, boro e ácido indolbutírico no enraizamento de estacas Vegetative propagation of Platanus acerifolia Ait: (II effect of zinc,boron, and indolbutiric acid on rooting of cuttings

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Fernando Teixeira Nicoloso

1999-09-01

Full Text Available O objetivo desse trabalho foi avaliar os efeitos da aplicação do zinco (Zn, boro (B e ácido indolbutírico (AIB no enraizamento de estacas de Platanus acerifolia Ait. Os tratamentos consistiram do condicionamento das estacas, coletadas em quatro épocas ao longo do ano e representando diferentes tipos fisiológicos, com: sulfato e cloreto de zinco (0, 2,5, 5, 10, 20 e 40mg l-1 Zn, ácido bórico (0, 50, 100, 150, 200 e 250mg l-1 H3BO3 e ácido indolbutírico (0, 20 e 40mg l-1 AIB, através de solução aquosa, pela imersão de 3cm da base da estaca, com duas lesões laterais de 2cm, por 24 horas. A estaquia foi feita em vasos contendo como substrato uma mistura de areia média e casca de arroz carbonizada (1:1, v/v, ambas lavadas. O experimento foi conduzido por 110 dias em casa de vegetação com aspersão intermitente. No encerramento do experimento, avaliaram-se os seguintes parâmetros: comprimento e número de raízes primárias por estaca, máteria seca de raízes por estaca e percentagem de enraizamento. A aplicação isolada de Zn e B não influencia o enraizamento das estacas. O condicionamento de estacas de ramos "do ano" basais finas com AIB afeta, negativamente, o percentual de enraizamento e, positivamente, o número de raízes por estaca.The aim of this work was to evaluate the effects of zinc (Zn, boron (B, and indolbutiric acid (IBA on rooting of Platanus acerifolia Ait. cuttings. The treatments of the cuttings, which were collected at four different times during the year and representing four physiological types of cuttings, were: zinc sulphate and chloride (0, 2,5, 5, 10, 20, and 40mg l-1 Zn, boric acid (0, 50, 100, 150, 200, and 250mg l-1 H3BO3, and indolbutiric acid (0, 20, and 40mg l-1 IBA. The treatments with B, Zn and IBA were done through submersion of 3cm of the cutting basis, during 24 hours, in an aqueous solution. The cuttings were rooted in pots containing as substrate a mixture of medium sand + carbonised rice

Defining restoration targets for water depth and salinity in wind-dominated Spartina patens (Ait.) Muhl. coastal marshes

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Nyman, J.A.; LaPeyre, Megan K.; Caldwell, Andral W.; Piazza, Sarai C.; Thom, C.; Winslow, C.

2009-01-01

Coastal wetlands provide valued ecosystem functions but the sustainability of those functions often is threatened by artificial hydrologic conditions. It is widely recognized that increased flooding and salinity can stress emergent plants, but there are few measurements to guide restoration, management, and mitigation. Marsh flooding can be estimated over large areas with few data where winds have little effect on water levels, but quantifying flooding requires hourly measurements over long time periods where tides are wind-dominated such as the northern Gulf of Mexico. Estimating salinity of flood water requires direct daily measurements because coastal marshes are characterized by dynamic salinity gradients. We analyzed 399,772 hourly observations of water depth and 521,561 hourly observations of water salinity from 14 sites in Louisiana coastal marshes dominated by Spartina patens (Ait.) Muhl. Unlike predicted water levels, observed water levels varied monthly and annually. We attributed those observed variations to variations in river runoff and winds. In stable marshes with slow wetland loss rates, we found that marsh elevation averaged 1 cm above mean high water, 15 cm above mean water, and 32 cm above mean low water levels. Water salinity averaged 3.7 ppt during April, May, and June, and 5.4 ppt during July, August, and September. The daily, seasonal, and annual variation in water levels and salinity that were evident would support the contention that such variation be retained when designing and operating coastal wetland management and restoration projects. Our findings might be of interest to scientists, engineers, and managers involved in restoration, management, and restoration in other regions where S. patens or similar species are common but local data are unavailable.

Desempenho agronômico do rabanete adubado com Calotropis procera (Ait. R. Br. em duas épocas de cultivo

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Antonia Francilene Alves da Silva

Full Text Available RESUMO Indicadores agronômicos foram avaliados no rabanete adubado com diferentes quantidades de biomassa de Calotropis procera (Ait. R. Br. (Flor-de-seda, em distintos tempos de incorporação ao solo e cultivada em duas épocas (primavera e outono-inverno, no município de Serra Talhada-PE. O delineamento experimental foi em blocos casualizados, com os tratamentos arranjados em esquema fatorial 4 x 4, com três repetições, sendo o primeiro fator: as quantidades de biomassa de C. procera (5,4; 8,8; 12,2 e 15,6 t ha-1 em base seca; e o segundo: tempos de incorporação ao solo (0; 10; 20 e 30 dias antes do plantio do rabanete. As características determinadas no rabanete foram: altura de plantas, número de folhas por planta, diâmetro de raízes, massas seca e fresca de raiz tuberosa, massa fresca de raiz comercial. O rendimento máximo do rabanete foi obtido na quantidade de biomassa de C. procera de 15,6 t ha-1 incorporada ao solo. Uma sincronia entre o fornecimento de nutrientes pelo adubo verde e o período de máxima demanda pelo rabanete foi observada no tempo de incorporação de 22 dias antes do plantio. O cultivo no outono-inverno aumentou o ciclo do rabanete, proporcionando maiores rendimentos comercial e total de raízes.

The efficacy and safety of standardized allergen-removed Rhus verniciflua extract as maintenance therapy after first-line chemotherapy in patients with advanced non-small cell lung cancer.

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Lee, Jinsoo; Chae, Jean; Lee, Sookyung; Kim, Kyungsuk; Eo, Wankyu; Kim, Sehyun; Choi, Woncheol; Cheon, Seong Ha

2013-01-01

Chemotherapy improves the survival of patients with advanced non-small cell lung cancer (NSCLC), but tumor progression is often inevitable. Strategies are needed to improve the therapeutic efficacy of chemotherapy. Over recent years, there has been increasing interest in the role of maintenance therapy after first-line chemotherapy. We investigated the efficacy and safety of standardized allergen-removed Rhus verniciflua Stokes extract (aRVS) as maintenance therapy in patients with non-progressive disease following first-line chemotherapy. We reviewed the medical records of 33 patients with advanced NSCLC, who started treatment with aRVS in a state of tumor regression or stable disease after completion of four or six cycles of induction chemotherapy at the Integrative Cancer Center, Kyung Hee University Hospital at Gangdong from June 2006 to April 2012. The primary objective of this study was progression-free survival (PFS) of aRVS as maintenance therapy. Secondary objectives included assessments of disease control rate (DCR), overall survival (OS), and the safety of aRVS treatment. The median PFS was 5.2 months with a 6- and 12-month PFS rate of 40.6% and 12.9%, respectively. The DCR was 93.9% and the median OS was 34.8 months. The overall survival rates at 12, 24, and 36 months were 84.2%, 76.7% and 49.9%, respectively. We observed no hematologic toxicity, nephrotoxicity, or hepatotoxicity during aRVS treatment. In conclusion, maintenance therapy with aRVS for patients with advanced NSCLC is well-tolerated and offers encouraging improved PFS and OS compared with historical controls. Our data provide further evidence that aRVS may be used beyond disease progression in this clinical setting.

Phytotoxicity and cytogenotoxicity of hydroalcoholic extracts from Solanum muricatum Ait. and Solanum betaceum Cav. (Solanaceae) in the plant model Lactuca sativa.

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Dos Santos, Fabio Eduardo; Carvalho, Marcos Schleiden Sousa; Silveira, Graciele Lurdes; Correa, Felipe Folgaroli; Cardoso, Maria das Graças; Andrade-Vieira, Larissa Fonseca; Vilela, Luciane Resende

2018-03-05

Plants are rich in biologically active compounds. They can be explored for the production of bioherbicides. In this context, the present work aimed to evaluate the allelopathic effect of hydroalcoholic extracts from two Solanaceae species: Solanum muricatum Ait. and Solanum betaceum Cav. For this end, we conducted phytochemical screening and biological assays, determining the effects of the extracts on germination, early development, cell cycle, and DNA fragmentation in plantlets and meristematic cells of the plant model Lactuca sativa L. (lettuce). The percentage of seeds germinated under effect of S. muricatum extract did not differ from the control, but plantlet growth was reduced at the highest concentrations. For S. betaceum extract, dose dependence was observed for both germination and plantlet development, with the highest concentrations inhibiting germination. The growth curves revealed the concentrations of 2.06 and 1.93 g/L for S. muricatum and S. betaceum extracts, respectively, as those reducing 50% of root growth (RG). At these concentrations, both extracts presented mitodepressive effect, besides inducing significant increase in the frequency of condensed nuclei, associated to DNA fragmentation and cytoplasmic shrinkage. The frequency of chromosome alterations was not significant. We further discuss the mechanisms of action related to the chemical composition of the extracts, which presented organic acids, reducing sugars, proteins, amino acids, and tannins, besides catechins and flavonoids, only found in the extract of S. betaceum.

A fire history derived from Pinus resinosa Ait. for the Islands of Eastern Lac La Croix, Minnesota, USA.

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Johnson, Lane B; Kipfmueller, Kurt F

2016-06-01

We reconstructed fire occurrence near a fur-trade era canoe travel corridor (used ca. 1780-1802) in the Quetico-Superior region west of Lake Superior to explore the possibility of human influence on pre-fire suppression rates of fire occurrence. Our research objectives were to (1) examine the spatial and temporal patterns of fire in the study area, (2) test fires' strength of association with regional drought, and (3) assess whether reconstructed fire frequencies could be explained by observed rates of lightning fire ignition over the modern period of record. We developed a 420-year fire history for the eastern portion of Lac La Croix in the Boundary Waters Canoe Area Wilderness (BWCAW). Seventy-one fire-scarred samples were collected from remnant Pinus resinosa Ait. (red pine) stumps and logs from thirteen distinct island and three mainland forest stands. Collectively these samples contained records of 255 individual fire scars representing 79 fire events from 1636 to 1933 (study area mean fire intervals [MFI] 3.8 yr). Reconstructed fires were spatially and temporally asynchronous and not strongly associated with regional drought (P > 0.05). When compared to the conservative, tree-ring reconstructed estimate of historical fire occurrence and modern lightning-caused fires (1929-2012), a noticeable change in the distribution and frequency of fires within the study area was evident with only two lightning-ignited island fires since 1934 in the study area. Our results suggest a high likelihood that indigenous land use contributed to surface fire ignitions within our study area and highlights the importance of examining the potential effects of past indigenous land use when determining modern approaches to fire and wilderness management in fire-adapted ecosystems.

Annotated genetic linkage maps of Pinus pinaster Ait. from a Central Spain population using microsatellite and gene based markers.

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de Miguel, Marina; de Maria, Nuria; Guevara, M Angeles; Diaz, Luis; Sáez-Laguna, Enrique; Sánchez-Gómez, David; Chancerel, Emilie; Aranda, Ismael; Collada, Carmen; Plomion, Christophe; Cabezas, José-Antonio; Cervera, María-Teresa

2012-10-04

Pinus pinaster Ait. is a major resin producing species in Spain. Genetic linkage mapping can facilitate marker-assisted selection (MAS) through the identification of Quantitative Trait Loci and selection of allelic variants of interest in breeding populations. In this study, we report annotated genetic linkage maps for two individuals (C14 and C15) belonging to a breeding program aiming to increase resin production. We use different types of DNA markers, including last-generation molecular markers. We obtained 13 and 14 linkage groups for C14 and C15 maps, respectively. A total of 211 and 215 markers were positioned on each map and estimated genome length was between 1,870 and 2,166 cM respectively, which represents near 65% of genome coverage. Comparative mapping with previously developed genetic linkage maps for P. pinaster based on about 60 common markers enabled aligning linkage groups to this reference map. The comparison of our annotated linkage maps and linkage maps reporting QTL information revealed 11 annotated SNPs in candidate genes that co-localized with previously reported QTLs for wood properties and water use efficiency. This study provides genetic linkage maps from a Spanish population that shows high levels of genetic divergence with French populations from which segregating progenies have been previously mapped. These genetic maps will be of interest to construct a reliable consensus linkage map for the species. The importance of developing functional genetic linkage maps is highlighted, especially when working with breeding populations for its future application in MAS for traits of interest.

Annotated genetic linkage maps of Pinus pinaster Ait. from a Central Spain population using microsatellite and gene based markers

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de Miguel Marina

2012-10-01

Full Text Available Abstract Background Pinus pinaster Ait. is a major resin producing species in Spain. Genetic linkage mapping can facilitate marker-assisted selection (MAS through the identification of Quantitative Trait Loci and selection of allelic variants of interest in breeding populations. In this study, we report annotated genetic linkage maps for two individuals (C14 and C15 belonging to a breeding program aiming to increase resin production. We use different types of DNA markers, including last-generation molecular markers. Results We obtained 13 and 14 linkage groups for C14 and C15 maps, respectively. A total of 211 and 215 markers were positioned on each map and estimated genome length was between 1,870 and 2,166 cM respectively, which represents near 65% of genome coverage. Comparative mapping with previously developed genetic linkage maps for P. pinaster based on about 60 common markers enabled aligning linkage groups to this reference map. The comparison of our annotated linkage maps and linkage maps reporting QTL information revealed 11 annotated SNPs in candidate genes that co-localized with previously reported QTLs for wood properties and water use efficiency. Conclusions This study provides genetic linkage maps from a Spanish population that shows high levels of genetic divergence with French populations from which segregating progenies have been previously mapped. These genetic maps will be of interest to construct a reliable consensus linkage map for the species. The importance of developing functional genetic linkage maps is highlighted, especially when working with breeding populations for its future application in MAS for traits of interest.

Rhus copallinum L.

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K.F Connor

2004-01-01

Shining sumac is an upright, deciduous, clonal shrub or (rarely) small tree from 3 to 6 m tall. Bark ranges in color from light brown to gray to reddish-brown. Shoots and twigs are hairy and reddish in color. Twigs have conspicuous lenticels. The sparsely branched, flat crown is composed of alternate, pinnately compound leaves approximately 15 to 30 cm long, with wings...

Köprüçay Irmağı (Antalya Bentik Omurgasız Faunası

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Melek ZEYBEK

2014-07-01

Full Text Available Bu çalışma, Köprüçay Irmağı bentik omurgasız faunasını belirlemek üzere Şubat 2008- Ocak 2009 tarihleri arasında 7 istasyondan bentik omurgasız örnekleri alınarak, gerçekleştirilmiştir. Çalışma sonunda toplam 85 takson ve bu taksonları oluşturan toplam 21318 birey tespit edilmiştir. Toplanan örneklerin incelenmesi sonucu Ephemeroptera takımına ait 26, Plecoptera takımına ait 6, Trichoptera takımına ait 23, Diptera takımına ait 11, Odonata takımına ait 8, Coleoptera takımına ait 4, Hemiptera takımına ait 1, Hirudinea sınıfına ait 1, Gastropoda sınıfına ait 2, Malacostraca sınıfına ait 3 takson teşhis edilmiştir. Bu çalışma Köprüçay Irmağı bentik faunasının belirlenmesine yönelik yapılmış ilk çalışmadır. Bu nedenle tespit edilen bütün taksonlar bölge için ilk kez bildirilmiştir.

Major Vegetation Types of the Soutpansberg Conservancy and the Blouberg Nature Reserve, South Africa

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Theo H.C. Mostert

2008-10-01

Full Text Available The Major Megetation Types (MVT and plant communities of the Soutpansberg Centre of Endemism are described in detail, with special reference to the Soutpansberg Conservancy and the Blouberg Nature Reserve. Phytosociological data from 442 sample plots were ordinated using a DEtrended CORrespondence ANAlysis (DECORANA and classified using TWo-Way INdicator SPecies ANalysis (TWINSPAN. The resulting classification was further refined with table-sorting procedures based on the Braun–Blanquet floristic–sociological approach of vegetation classification using MEGATAB. Eight MVT’s were identified and described as Eragrostis lehmanniana var. lehmanniana–Sclerocarya birrea subsp. caffra Blouberg Northern Plains Bushveld, Euclea divinorum–Acacia tortilis Blouberg Southern Plains Bushveld, Englerophytum magalismontanum–Combretum molle Blouberg Mountain Bushveld, Adansonia digitata–Acacia nigrescens Soutpansberg Arid Northern Bushveld, Catha edulis–Flueggia virosa Soutpansberg Moist Mountain Thickets, Diplorhynchus condylocarpon–Burkea africana Soutpansberg Leached Sandveld, Rhus rigida var. rigida–Rhus magalismontanum subsp. coddii Soutpansberg Mistbelt Vegetation and Xymalos monospora–Rhus chirendensis Soutpansberg Forest Vegetation.

Chemical composition of essential oil of exudates of Dryobalanops ...

African Journals Online (AJOL)

Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia, ... Gas chromatography-mass spectrometry (GC-MS) was used to characterize the ... Conclusion: Essential oil from the exudates of D. aromatica contains ..... industries.

Low- and high-volume of intensive endurance training significantly improves maximal oxygen uptake after 10-weeks of training in healthy men.

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Arnt Erik Tjønna

Full Text Available Regular exercise training improves maximal oxygen uptake (VO2max, but the optimal intensity and volume necessary to obtain maximal benefit remains to be defined. A growing body of evidence suggests that exercise training with low-volume but high-intensity may be a time-efficient means to achieve health benefits. In the present study, we measured changes in VO2max and traditional cardiovascular risk factors after a 10 wk. training protocol that involved three weekly high-intensity interval sessions. One group followed a protocol which consisted of 4×4 min at 90% of maximal heart rate (HRmax interspersed with 3 min active recovery at 70% HRmax (4-AIT, the other group performed a single bout protocol that consisted of 1×4 min at 90% HRmax (1-AIT. Twenty-six inactive but otherwise healthy overweight men (BMI: 25-30, age: 35-45 y were randomized to either 1-AIT (n = 11 or 4-AIT (n = 13. After training, VO2max increased by 10% (∼5.0 mL⋅kg(-1⋅min(-1 and 13% (∼6.5 mL⋅kg(-1⋅min(-1 after 1-AIT and 4-AIT, respectively (group difference, p = 0.08. Oxygen cost during running at a sub-maximal workload was reduced by 14% and 13% after 1-AIT and 4-AIT, respectively. Systolic blood pressure decreased by 7.1 and 2.6 mmHg after 1-AIT and 4-AIT respectively, while diastolic pressure decreased by 7.7 and 6.1 mmHg (group difference, p = 0.84. Both groups had a similar ∼5% decrease in fasting glucose. Body fat, total cholesterol, LDL-cholesterol, and ox-LDL cholesterol only were significantly reduced after 4-AIT. Our data suggest that a single bout of AIT performed three times per week may be a time-efficient strategy to improve VO2max and reduce blood pressure and fasting glucose in previously inactive but otherwise healthy middle-aged individuals. The 1-AIT type of exercise training may be readily implemented as part of activities of daily living and could easily be translated into programs designed to improve public health

The effect of biochar, cocopeat and saw dust compost on the growth of two dipterocarps seedlings

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MARJENAH

2016-01-01

Full Text Available Abstract. Marjenah, Kiswanto, Purwanti S, Sofyan FPM. 2016. The effect of biochar, cocopeat and saw dust compost on the growth of two dipterocarps seedlings. Nusantara Bioscience 8: 39-44. Good growing media contains enough nutrients, light textured, and have the capacity to hold water to create conditions that can support plant growth. The growing media used for propagation has several requirements, that is firm and dense to enhance the growth of stems, has the capability to hold water, guarantee the plant life, and moderate humidity. This study attempts to evaluate the effect of biochar, cocopeat, and saw dust compost on the growth of Dryobalanops aromatica and Shorea balangeran seedlings. An experiment was conducted by using completely randomized block design (CRBD in factorial with two factors, namely growing media (top soil 100%; top soil 80% + saw dust compost 20%; top soil 80% + biochar 20%, top soil 80% + 20% coco peat and two species of dipterocarps seedlings (D. aromatica and S. balangeran. The experiment was carried out in a Forestry Faculty nursery during 3 months. To determine the best growth media, the vegetative parameters of seedlings were measured and the data were statistically analyzed. Survival rates of both of seedlings showed good specification in all types of growing media. The survival rates of D. aromatica for 100% top soil (control; 80% top soil+ 20% sawdust compost; 80% topsoil + 20% biochar; 80% top soil + 20% cocopeat are 100%; 100%; 97.78% and 97.78%; respectively. S. balangeran are 93.33%; 100%; 100%; 97.78%. Quality Index of D. aromatica 100% top soil (control; 80% top soil+ 20% sawdust compost; 80% topsoil + 20% biochar; 80% top soil + 20% cocopeat that are 0.15; 0.14; 0.10; and 0.10; and for S. balangeran 0.09; 0.38; 0.05 and 0.07 respectively.

Allergen immunotherapy in people, dogs, cats and horses - differences, similarities and research needs.

Science.gov (United States)

Mueller, R S; Jensen-Jarolim, E; Roth-Walter, F; Marti, E; Janda, J; Seida, A A; DeBoer, D

2018-04-19

In human patients with seasonal allergic rhinoconjunctivitis sensitized to grass pollen, the first successful allergen immunotherapy (AIT) was reported in 1911. Today, immunotherapy is an accepted treatment for allergic asthma, allergic rhinitis and hypersensitivities to insect venom. AIT is also used for atopic dermatitis and recently for food allergy. Subcutaneous, epicutaneous, intralymphatic, oral and sublingual protocols of AIT exist. In animals, most data are available in dogs where subcutaneous AIT is an accepted treatment for atopic dermatitis. Initiating a regulatory response and a production of "blocking" IgG antibodies with AIT are similar mechanisms in human beings and dogs with allergic diseases. Although subcutaneous immunotherapy is used for atopic dermatitis in cats, data for its efficacy is sparse. There is some evidence for successful treatment of feline asthma with AIT. In horses, most studies evaluate the effect of AIT on insect hypersensitivity with conflicting results though promising pilot studies have demonstrated the prophylaxis of insect hypersensitivity with recombinant antigens of biting midges (Culicoides spp.). Optimising AIT using allergoids, peptide immunotherapy, recombinant allergens and new adjuvants with the different administration types of allergen extracts hopefully will further improve compliance and efficacy of this proven treatment modality. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

The chalcone butein from Rhus verniciflua Stokes inhibits clonogenic growth of human breast cancer cells co-cultured with fibroblasts

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Tan Jenny

2005-03-01

Full Text Available Abstract Background Butein (3,4,2',4'-tetrahydroxychalone, a plant polyphenol, is a major biologically active component of the stems of Rhus verniciflua Stokes. It has long been used as a food additive in Korea and as an herbal medicine throughout Asia. Recently, butein has been shown to suppress the functions of fibroblasts. Because fibroblasts are believed to play an important role in promoting the growth of breast cancer cells, we investigated the ability of butein to inhibit the clonogenic growth of small numbers of breast cancer cells co-cultured with fibroblasts in vitro. Methods We first measured the clonogenic growth of small numbers of the UACC-812 human breast cancer cell line co-cultured on monolayers of serum-activated, human fibroblasts in the presence of butein (2 μg/mL or various other modulators of fibroblast function (troglitazone-1 μg/mL; GW9662-1 μM; meloxican-1 μM; and 3,4 dehydroproline-10 μg/mL. In a subsequent experiment, we measured the dose-response effect on the clonogenic growth of UACC-812 breast cancer cells by pre-incubating the fibroblasts with varying concentrations of butein (10 μg/ml-1.25 μg/mL. Finally, we measured the clonogenic growth of primary breast cancer cells obtained from 5 clinical specimens with normal fibroblasts and with fibroblasts that had been pre-treated with a fixed dose of butein (2.5 μg/mL. Results Of the five modulators of fibroblast function that we tested, butein was by far the most potent inhibitor of clonogenic growth of UACC-812 breast cancer cells co-cultured with fibroblasts. Pre-treatment of fibroblasts with concentrations of butein as low as 2.5 μg/mL nearly abolished subsequent clonogenic growth of UACC-812 breast cancer cells co-cultured with the fibroblasts. A similar dose of butein had no effect on the clonogenic growth of breast cancer cells cultured in the absence of fibroblasts. Significantly, clonogenic growth of the primary breast cancer cells was also

A new occurrence of ambient inclusion trails from the ~1900-million-year-old Gunflint Formation, Ontario: nanocharacterization and testing of potential formation mechanisms.

Science.gov (United States)

Wacey, D; Saunders, M; Kong, C; Kilburn, M R

2016-09-01

Ambient inclusion trails (AITs) are tubular microstructures thought to form when a microscopic mineral crystal is propelled through a fine-grained rock matrix. Here, we report a new occurrence of AITs from a fossilized microbial mat within the 1878-Ma Gunflint Formation, at Current River, Ontario. The AITs are 1-15 μm in diameter, have pyrite as the propelled crystal, are infilled with chlorite and have been propelled through a microquartz (chert) or chlorite matrix. AITs most commonly originate at the boundary between pyrite- and chlorite-rich laminae and chert-filled fenestrae, with pyrite crystals propelled into the fenestrae. A subset of AITs originate within the fenestrae, rooted either within the chert or within patches of chlorite. Sulphur isotope data ((34) S/(32) S) obtained in situ from AIT pyrite have a δ(34) S of -8.5 to +8.0 ‰, indicating a maximum of ~30 ‰ fractionation from Palaeoproterozoic seawater sulphate (δ(34) S ≈ +20 ‰). Organic carbon is common both at the outer margins of the fenestrae and in patches of chlorite where most AITs originate, and can be found in smaller quantities further along some AITs towards the terminal pyrite grain. We infer that pyrite crystals now found within the AITs formed via the action of heterotrophic sulphate-reducing bacteria during early diagenesis within the microbial mat, as pore waters were becoming depleted in seawater sulphate. Gases derived from this process such as CO2 and H2 S were partially trapped within the microbial mat, helping produce birds-eye fenestrae, while rapid microquartz precipitation closed porosity. We propose that propulsion of the pyrite crystals to form AITs was driven by two complementary mechanisms during burial and low-grade metamorphism: firstly, thermal decomposition of residual organic material providing CO2 , and potentially CH4 , as propulsive gases, plus organic acids to locally dissolve the microquartz matrix; and secondly, reactions involving clay minerals that

Soil water stress affects both cuticular wax content and cuticle-related gene expression in young saplings of maritime pine (Pinus pinaster Ait).

Science.gov (United States)

Le Provost, Grégoire; Domergue, Frédéric; Lalanne, Céline; Ramos Campos, Patricio; Grosbois, Antoine; Bert, Didier; Meredieu, Céline; Danjon, Frédéric; Plomion, Christophe; Gion, Jean-Marc

2013-07-01

The cuticle is a hydrophobic barrier located at the aerial surface of all terrestrial plants. Recent studies performed on model plants, such as Arabidopsis thaliana, have suggested that the cuticle may be involved in drought stress adaptation, preventing non-stomatal water loss. Although forest trees will face more intense drought stresses (in duration and intensity) with global warming, very few studies on the role of the cuticle in drought stress adaptation in these long-lived organisms have been so far reported. This aspect was investigated in a conifer, maritime pine (Pinus pinaster Ait.), in a factorial design with two genetic units (two half-sib families with different growth rates) and two treatments (irrigated vs non-irrigated), in field conditions. Saplings were grown in an open-sided greenhouse and half were irrigated three times per week for two growing seasons. Needles were sampled three times per year for cuticular wax (composition and content) and transcriptome (of 11 genes involved in cuticle biosynthesis) analysis. Non-irrigated saplings (i) had a higher cuticular wax content than irrigated saplings and (ii) overexpressed most of the genes studied. Both these trends were more marked in the faster growing family. The higher cuticular wax content observed in the non-irrigated treatment associated with strong modifications in products from the decarbonylation pathway suggest that cuticular wax may be involved in drought stress adaptation in maritime pine. This study provides also a set of promising candidate genes for future forward genetic studies in conifers.

EAACI Guidelines on Allergen Immunotherapy

DEFF Research Database (Denmark)

Muraro, A; Roberts, G; Halken, S

2018-01-01

conflicting outcomes. This has resulted in confusion about the benefits and risks of AIT amongst policymakers and professionals, as well as in the variable availability of AIT products, regulation and reimbursement policies globally. In 2015 EAACI initiated the AIT Guidelines project as part...

Longer-term Baerveldt to Trabectome glaucoma surgery comparison using propensity score matching.

Science.gov (United States)

Kostanyan, Tigran; Shazly, Tarek; Kaplowitz, Kevin B; Wang, Steven Z; Kola, Sushma; Brown, Eric N; Loewen, Nils A

2017-12-01

To apply propensity score matching to compare Baerveldt glaucoma drainage implant (BGI) to Trabectome-mediated ab interno trabeculectomy (AIT). Recent data suggests that AIT can produce results similar to BGI which is traditionally reserved for more severe glaucoma. BGI and AIT patients with at least 1 year of follow-up were included. The primary outcome measures were intraocular pressure (IOP), number of glaucoma medications, and a Glaucoma Index (GI) score. GI reflected glaucoma severity based on visual field, the number of preoperative medications, and preoperative IOP. Score matching used a genetic algorithm consisting of age, gender, type of glaucoma, concurrent phacoemulsification, baseline number of medications, and baseline IOP. Patients with neovascular glaucoma, with prior glaucoma surgery, or without a close match were excluded. Of 353 patients, 30 AIT patients were matched to 29 BGI patients. Baseline characteristics including, IOP, the number of glaucoma medications, type of glaucoma, the degree of VF loss and GI were not significantly different between AIT and BGI. BGI had a preoperative IOP of 21.6 ± 6.3 mmHg compared to 21.5 ± 7.4 for AIT on 2.8 ± 1.1 medications and 2.5 ± 2.3 respectively. At 30 months, the mean IOP was 15.0 ± 3.9 mmHg for AIT versus 15.0 ± 5.7 mmHg for BGI (p > 0.05), while the number of drops was 1.5 ± 1.3 for AIT (change: p = 0.001) versus 2.4 ± 1.2 for BGI (change: p = 0.17; AIT vs BGI: 0.007). Success, defined as IOP  0.05) and 50% versus 52% at 2.5 years. A propensity score matched comparison of AIT and BGI demonstrated a similar IOP reduction through 1 year. AIT required fewer medications.

Autoimmune Thyroiditis: Clinical Course Features and Principles of Differential Therapy

Directory of Open Access Journals (Sweden)

L.Ye. Bobyryova

2014-02-01

Full Text Available Constant increase in the incidence of autoimmune thyroiditis (AIT in different regions of Ukraine puts this problem in actual number that determines the need to identify features of the clinical course of AIT, the principles of differentiated treatment depending on the nature of the metabolic changes and taking into account regional differences in thyroid pathology, particularly AIT. The paper presents data on the study of features of clinical course and complex treatment of AIT.

Wild Blueberry (Vaccinium angustifolium Ait.) Polyphenols Target Fusobacterium nucleatum and the Host Inflammatory Response: Potential Innovative Molecules for Treating Periodontal Diseases.

Science.gov (United States)

Ben Lagha, Amel; Dudonné, Stéphanie; Desjardins, Yves; Grenier, Daniel

2015-08-12

Blueberries contain significant amounts of flavonoids to which a number of beneficial health effects in humans have been associated. The present study investigated the effect of a polyphenol-rich lowbush blueberry (Vaccinium angustifolium Ait.) extract on the two main etiologic components of periodontitis, a multifactorial disorder affecting the supporting structures of the teeth. Phenolic acids, flavonoids (flavonols, anthocyanins, flavan-3-ols), and procyanidins made up 16.6, 12.9, and 2.7% of the blueberry extract, respectively. The blueberry extract showed antibacterial activity (MIC = 1 mg/mL) against the periodontopathogenic bacterium Fusobacterium nucleatum. This property may result from the ability of blueberry polyphenols to chelate iron. Moreover, the blueberry extract at 62.5 μg/mL inhibited F. nucleatum biofilm formation by 87.5 ± 2.3%. Subsequently, the ability of the blueberry extract to inhibit the NF-κB signaling pathway in U937-3xκB cells was investigated. The blueberry extract dose-dependently inhibited the activation of NF-κB induced by F. nucleatum. In addition, a pretreatment of macrophages with the blueberry extract (62.5 μg/mL) inhibited the secretion of IL-1β, TNF-α, and IL-6 by 87.3 ± 1.3, 80.7 ± 5.6, and 28.2 ± 9.3%, respectively, following a stimulation with F. nucleatum. Similarly, the secretion of MMP-8 and MMP-9 was also dose-dependently inhibited. This dual antibacterial and anti-inflammatory action of lowbush blueberry polyphenols suggests that they may be promising candidates for novel therapeutic agents.

A Quantile Regression Approach to Estimating the Distribution of Anesthetic Procedure Time during Induction.

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Hsin-Lun Wu

Full Text Available Although procedure time analyses are important for operating room management, it is not easy to extract useful information from clinical procedure time data. A novel approach was proposed to analyze procedure time during anesthetic induction. A two-step regression analysis was performed to explore influential factors of anesthetic induction time (AIT. Linear regression with stepwise model selection was used to select significant correlates of AIT and then quantile regression was employed to illustrate the dynamic relationships between AIT and selected variables at distinct quantiles. A total of 1,060 patients were analyzed. The first and second-year residents (R1-R2 required longer AIT than the third and fourth-year residents and attending anesthesiologists (p = 0.006. Factors prolonging AIT included American Society of Anesthesiologist physical status ≧ III, arterial, central venous and epidural catheterization, and use of bronchoscopy. Presence of surgeon before induction would decrease AIT (p < 0.001. Types of surgery also had significant influence on AIT. Quantile regression satisfactorily estimated extra time needed to complete induction for each influential factor at distinct quantiles. Our analysis on AIT demonstrated the benefit of quantile regression analysis to provide more comprehensive view of the relationships between procedure time and related factors. This novel two-step regression approach has potential applications to procedure time analysis in operating room management.

A review of clinical efficacy, safety, new developments and adherence to allergen-specific immunotherapy in patients with allergic rhinitis caused by allergy to ragweed pollen (Ambrosia artemisiifolia).

Science.gov (United States)

Turkalj, Mirjana; Banic, Ivana; Anzic, Srdjan Ante

2017-01-01

Allergic rhinitis is a common health problem in both children and adults. The number of patients allergic to ragweed ( Ambrosia artemisiifolia ) is on the rise throughout Europe, having a significant negative impact on the patients' and their family's quality of life. Allergen-specific immunotherapy (AIT) has disease-modifying effects and can induce immune tolerance to allergens. Both subcutaneous immunotherapy and sublingual immunotherapy with ragweed extracts/preparations have clear positive clinical efficacy, especially over pharmacological treatment, even years after the treatment has ended. AIT also has very good safety profiles with extremely rare side effects, and the extracts/preparations used in AIT are commonly well tolerated by patients. However, patient adherence to treatment with AIT seems to be quite low, mostly due to the fact that treatment with AIT is relatively time-demanding and, moreover, due to patients not receiving adequate information and education about the treatment before it starts. AIT is undergoing innovations and improvements in clinical efficacy, safety and patient adherence, especially with new approaches using new adjuvants, recombinant or modified allergens, synthetic peptides, novel routes of administration (epidermal or intralymphatic), and new protocols, which might make AIT more acceptable for a wider range of patients and novel indications. Patient education and support (eg, recall systems) is one of the most important goals for AIT in the future, to further enhance treatment success.

Transit space

DEFF Research Database (Denmark)

Raahauge, Kirsten Marie

2008-01-01

This article deals with representations of one specific city, Århus, Denmark, especially its central district. The analysis is based on anthropological fieldwork conducted in Skåde Bakker and Fedet, two well-off neighborhoods. The overall purpose of the project is to study perceptions of space...... and the interaction of cultural, social, and spatial organizations, as seen from the point of view of people living in Skåde Bakker and Fedet. The focus is on the city dwellers’ representations of the central district of Århus with specific reference to the concept of transit space. When applied to various Århusian...

Allergen immunotherapy for the prevention of allergic disease

DEFF Research Database (Denmark)

Dhami, Sangeeta; Nurmatov, Ulugbek; Halken, Susanne

2016-01-01

BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Prevention of Allergic Disease. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in the pre......BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Prevention of Allergic Disease. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT...

Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving.

Science.gov (United States)

Li, Xuan; Witonsky, Kailyn R; Lofaro, Olivia M; Surjono, Felicia; Zhang, Jianjun; Bossert, Jennifer M; Shaham, Yavin

2018-02-28

Relapse to methamphetamine (Meth) seeking progressively increases after withdrawal from drug self-administration (incubation of Meth craving). We previously demonstrated a role of dorsomedial striatum (DMS) dopamine D1 receptors (D1Rs) in this incubation. Here, we studied the role of afferent glutamatergic projections into the DMS and local D1R-glutamate interaction in this incubation in male rats. We first measured projection-specific activation on day 30 relapse test by using cholera toxin b (retrograde tracer) + Fos (activity marker) double-labeling in projection areas. Next, we determined the effect of pharmacological reversible inactivation of lateral or medial anterior intralaminar nuclei of thalamus (AIT-L or AIT-M) on incubated Meth seeking on withdrawal day 30. We then used an anatomical asymmetrical disconnection procedure to determine whether an interaction between AIT-L→DMS glutamatergic projections and postsynaptic DMS D1Rs contributes to incubated Meth seeking. We also determined the effect of unilateral inactivation of AIT-L and D1R blockade of DMS on incubated Meth seeking, and the effect of contralateral disconnection of AIT-L→DMS projections on nonincubated Meth seeking on withdrawal day 1. Incubated Meth seeking was associated with selective activation of AIT→DMS projections; other glutamatergic projections to DMS were not activated. AIT-L (but not AIT-M) inactivation or anatomical disconnection of AIT-L→DMS projections decreased incubated Meth seeking. Unilateral inactivation of AIT-L or D1R blockade of the DMS had no effect on incubated Meth craving, and contralateral disconnection of AIT-L→DMS projections had no effect on nonincubated Meth seeking. Our results identify a novel role of AIT-L and AIT-L→DMS glutamatergic projections in incubation of drug craving and drug seeking. SIGNIFICANCE STATEMENT Methamphetamine seeking progressively increases after withdrawal from drug self-administration, a phenomenon termed incubation of

"Contrasting patterns of selection at Pinus pinaster Ait. Drought stress candidate genes as revealed by genetic differentiation analyses".

Science.gov (United States)

Eveno, Emmanuelle; Collada, Carmen; Guevara, M Angeles; Léger, Valérie; Soto, Alvaro; Díaz, Luis; Léger, Patrick; González-Martínez, Santiago C; Cervera, M Teresa; Plomion, Christophe; Garnier-Géré, Pauline H

2008-02-01

The importance of natural selection for shaping adaptive trait differentiation among natural populations of allogamous tree species has long been recognized. Determining the molecular basis of local adaptation remains largely unresolved, and the respective roles of selection and demography in shaping population structure are actively debated. Using a multilocus scan that aims to detect outliers from simulated neutral expectations, we analyzed patterns of nucleotide diversity and genetic differentiation at 11 polymorphic candidate genes for drought stress tolerance in phenotypically contrasted Pinus pinaster Ait. populations across its geographical range. We compared 3 coalescent-based methods: 2 frequentist-like, including 1 approach specifically developed for biallelic single nucleotide polymorphisms (SNPs) here and 1 Bayesian. Five genes showed outlier patterns that were robust across methods at the haplotype level for 2 of them. Two genes presented higher F(ST) values than expected (PR-AGP4 and erd3), suggesting that they could have been affected by the action of diversifying selection among populations. In contrast, 3 genes presented lower F(ST) values than expected (dhn-1, dhn2, and lp3-1), which could represent signatures of homogenizing selection among populations. A smaller proportion of outliers were detected at the SNP level suggesting the potential functional significance of particular combinations of sites in drought-response candidate genes. The Bayesian method appeared robust to low sample sizes, flexible to assumptions regarding migration rates, and powerful for detecting selection at the haplotype level, but the frequentist-like method adapted to SNPs was more efficient for the identification of outlier SNPs showing low differentiation. Population-specific effects estimated in the Bayesian method also revealed populations with lower immigration rates, which could have led to favorable situations for local adaptation. Outlier patterns are discussed

Avaliação de inseticidas no controle de Sitophilus oryzae (Linnaeus (Coleoptera, Curculionidae e Rhyzopertha dominica (Fabricius (Coleoptera, Bostrichidae em trigo armazenado Efficacy of insecticides to control Sitophilus oryzae (Linnaeus (Coleoptera, Curculionidae and Rhyzopertha dominica (Fabricius (Coleoptera, Bostrichidae in stored wheat

Directory of Open Access Journals (Sweden)

Rui S. Furiatti

1999-03-01

Full Text Available The efficiency of insecticides against Sitophilus oryzae (Linnaeus, 1763 (Coleoptera, Curculionidae and Rhyzopertha dominica (Fabricius, 1792 (Coleoptera, Bostrichidae was determined exposing them to treated wheat in laboratory. Each plot, which was composed by 1.2 kg of wheat grain, was treated with 5 ml of the concentration/kg of wheat using a propelling air atomizer. Fifteen days after treatment 50 g samples of the grain were taken, from each plot, placed in plastic jars into which 10 adult insects of each species were released. This was repeated every 30 days until 165 days after treatment. The number of dead insects was counted 15 days after each infestation thus the evaluations were made at 30, 60, 90, 120, 150 and 180 days after the insecticide application. Esfenvalerate+fenitrothion+pyperonil butoxide (0,375+7,5+3,0 and 0,5+10,0+4,0 g a.i./t, fenitrothion+esfen-valerate (7,5+0,375 and 10,0+0,375 g a.i./t, fenitrothion+synergised deltamethrin (7,5+0,375 g a.i./t and fenitrothion (7,5 g a.i./t were effective against Sitophilus oryzae until 180 days after treatment. Esfenvalerate+fenitrothion+pyperonil butoxide (0,5+10,0+4,0 g a.i./t, fenitrothion+esfenvalerate (7,5+0,375 and 10,0+0,375 g a.i./t, fenitrothion+synergised deltamethrin (7,5+0,375 g a.i./t were effective against R. dominica until 180 days after treatment. Synergised deltamethrin (0,375 g a.i./t was effective against S. oryzae until 150 days and against R. dominica until 120 days after treatment. Esfenvalerate (0,5 g a.i./t was ineffective against S. oryzae and effective until 60 days after treatment against R. dominica. Fenitrothion (7,5 g a.i./t was ineffective against R. dominica. The use of mixtures of organophosphorus plus pyrethroids were more effective against S. oryzae and R. dominica when compared with these insecticides used alone.

Phylogenetic and morphological re-evaluation of the Botryosphaeria species causing diseases of Mangifera indica

NARCIS (Netherlands)

Slippers, B.; Johnson, G.I.; Crous, P.W.; Coutinho, T.A.; Wingfield, B.D.; Wingfield, M.J.

2005-01-01

Species of Botryosphaeria are among the most serious pathogens that affect mango trees and fruit. Several species occur on mangoes, and these are identified mainly on the morpholopy of the anamorphs. Common taxa include Dothiorella dominicana, D. mangiferae (= Natrassia mangiferae), D. aromatica and

Dicty_cDB: VFA387 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available e) Dechloromonas aromatica RCB, comp... 315 3e-84 CU633749_120( CU633749 |pid:none) Cupriavidus taiwanensis ...complet... 313 1e-83 CU633749_1505( CU633749 |pid:none) Cupriavidus taiwanensis str. LM... 313 1e-83 protein

Biomarkers for Monitoring Clinical Efficacy of Allergen Immunotherapy for Allergic Rhinoconjunctivitis and Allergic Asthma

DEFF Research Database (Denmark)

Shamji, M H; Kappen, J H; Akdis, M

2017-01-01

be administered either subcutaneously (SCIT) or sublingually (SLIT) (3-12). Although AIT is effective, the degree of remission strongly varies depending on the complex interaction between patient, allergy, symptomatology and vaccines used for AIT (3-9). Clinical management of patients receiving AIT and efficacy...... medicine (18). This article is protected by copyright. All rights reserved....

Autoimmune Thyroiditis and Glomerulopathies

Directory of Open Access Journals (Sweden)

Domenico Santoro

2017-06-01

Full Text Available Autoimmune thyroiditis (AIT is generally associated with hypothyroidism. It affects ~2% of the female population and 0.2% of the male population. The evidence of thyroid function- and thyroid autoantibody-unrelated microproteinuria in almost half of patients with AIT and sometimes heavy proteinuria as in the nephrotic syndrome point to a link of AIT with renal disease. The most common renal diseases observed in AIT are membranous nephropathy, membranoproliferative glomerulonephritis, minimal change disease, IgA nephropathy, focal segmental glomerulosclerosis, antineutrophil cytoplasmic autoantibody (ANCA vasculitis, and amyloidosis. Different hypotheses have been put forward regarding the relationship between AIT and glomerulopathies, and several potential mechanisms for this association have been considered. Glomerular deposition of immunocomplexes of thyroglobulin and autoantibodies as well as the impaired immune tolerance for megalin (a thyrotropin-regulated glycoprotein expressed on thyroid cells are the most probable mechanisms. Cross-reactivity between antigens in the setting of genetic predisposition has been considered as a potential mechanism that links the described association between ANCA vasculitis and AIT.

Quantitative thyroid scintigraphy for the differentiation of Graves' disease and hyperthyroid autoimmune thyroiditis

International Nuclear Information System (INIS)

Sahlmann, C.O.; Siefker, U.; Lehmann, K.; Harms, E.; Conrad, M.; Meller, J.

2004-01-01

The purpose of this study is the evaluation of the TCTUs in the differentiation between AIT and GD in patients with hyperthyroidism. Methods: We determined the TCTUs in 59 patients with untreated hyperthyroid GD and in 51 patients with AIT who had subclinical or manifest hyperthyroidism without medication. Patients with GD were characterized by the presence of hyperthyroidism, decreased echogenicity of the thyroid, elevation of TSH-receptor autoantibodies (TRAb). AIT was defined by a decreased echogenicity of the thyroid, absence of elevated TSH-receptor autoantibodies (TRAb), autoantibodies against the thyroid peroxidase (anti-TPO) and spontaneous remission or development of subclinical hypothyroidism within 3 months. Results: Thyroid volumes of patients with AIT were significantly lower than those of patients with GD (p 99m TcO 4 - offered rapid and reliable differentiation between hyperthyroid GD and AIT. (orig.)

Denmark's net'zero energy home'

DEFF Research Database (Denmark)

Hansen, Ellen Kathrine

2010-01-01

Judging by looks alone, you'd never guess that the simple one-and-a-half-story house on a residential street outside Århus, Denmark, is anything more than an ordinary single-family home. The stylish little house has the broad windows and long sloping roof of a typical Scandinavian home; a trampol......Judging by looks alone, you'd never guess that the simple one-and-a-half-story house on a residential street outside Århus, Denmark, is anything more than an ordinary single-family home. The stylish little house has the broad windows and long sloping roof of a typical Scandinavian home...

Dicty_cDB: AFM534 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available chloromonas aromatica RCB, comp... 315 2e-84 CU633749_120( CU633749 |pid:none) Cupriavidus taiwan...et... 313 9e-84 CU633749_1505( CU633749 |pid:none) Cupriavidus taiwanensis str. LM... 313 9e-84 (Q5XIT9) Rec

A review of clinical efficacy, safety, new developments and adherence to allergen-specific immunotherapy in patients with allergic rhinitis caused by allergy to ragweed pollen (Ambrosia artemisiifolia

Directory of Open Access Journals (Sweden)

Turkalj M

2017-02-01

Full Text Available Mirjana Turkalj,1,2 Ivana Banic,1 Srdjan Ante Anzic1 1Children’s Hospital Srebrnjak, Zagreb, 2Faculty of Medicine, JJ Strossmayer University of Osijek, Osijek, Croatia Abstract: Allergic rhinitis is a common health problem in both children and adults. The number of patients allergic to ragweed (Ambrosia artemisiifolia is on the rise throughout Europe, having a significant negative impact on the patients’ and their family’s quality of life. Allergen-specific immunotherapy (AIT has disease-modifying effects and can induce immune tolerance to allergens. Both subcutaneous immunotherapy and sublingual immunotherapy with ragweed extracts/preparations have clear positive clinical efficacy, especially over pharmacological treatment, even years after the treatment has ended. AIT also has very good safety profiles with extremely rare side effects, and the extracts/preparations used in AIT are commonly well tolerated by patients. However, patient adherence to treatment with AIT seems to be quite low, mostly due to the fact that treatment with AIT is relatively time-demanding and, moreover, due to patients not receiving adequate information and education about the treatment before it starts. AIT is undergoing innovations and improvements in clinical efficacy, safety and patient adherence, especially with new approaches using new adjuvants, recombinant or modified allergens, synthetic peptides, novel routes of administration (epidermal or intralymphatic, and new protocols, which might make AIT more acceptable for a wider range of patients and novel indications. Patient education and support (eg, recall systems is one of the most important goals for AIT in the future, to further enhance treatment success. Keywords: allergic rhinitis, allergy, ragweed, allergen-specific immunotherapy, Ambrosia artemisiifolia

Quantitative thyroid scintigraphy for the differentiation of Graves' disease and hyperthyroid autoimmune thyroiditis

Energy Technology Data Exchange (ETDEWEB)

Sahlmann, C.O.; Siefker, U.; Lehmann, K.; Harms, E.; Conrad, M.; Meller, J. [Goettingen Univ. (Germany). Abt. fuer Nuklearmedizin

2004-08-01

The purpose of this study is the evaluation of the TCTUs in the differentiation between AIT and GD in patients with hyperthyroidism. Methods: We determined the TCTUs in 59 patients with untreated hyperthyroid GD and in 51 patients with AIT who had subclinical or manifest hyperthyroidism without medication. Patients with GD were characterized by the presence of hyperthyroidism, decreased echogenicity of the thyroid, elevation of TSH-receptor autoantibodies (TRAb). AIT was defined by a decreased echogenicity of the thyroid, absence of elevated TSH-receptor autoantibodies (TRAb), autoantibodies against the thyroid peroxidase (anti-TPO) and spontaneous remission or development of subclinical hypothyroidism within 3 months. Results: Thyroid volumes of patients with AIT were significantly lower than those of patients with GD (p<0.05). TRAb levels were significantly higher in GD-patients (median: 19.5 U/ml; range: 15.3-35 U/ml) than in AIT-patients (median: 1.3 U/ml; range: 0-4.1 U/ml). 73% (38/59) of patients with GD had elevated anti-TPO levels. In these patients anti-TPO levels (median: 768 U/l; range: 83-6397 U/l) were not significantly different from anti-TPO levels of patients with AIT (median: 834 U/l; range: 107-8675 U/l; p=0.17). TCTUs values of patients with AIT were significantly lower (p<0.05; median: 0.9%; range: 0.1-3.2%) than those of patients with GD (median: 5.7%; range: 1.9-28.3%). Conclusion: In our patients quantitative thyroid scintigraphy with {sup 99m}TcO{sub 4}{sup -} offered rapid and reliable differentiation between hyperthyroid GD and AIT. (orig.)

Modelling modulus of elasticity of Pinus pinaster Ait. in northwestern Spain with standing tree acoustic measurements, tree, stand and site variables

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Esther Merlo

2014-04-01

Full Text Available Aim of study: Modelling the structural quality of Pinus pinaster Ait. wood on the basis of measurements made on standing trees is essential because of the importance of the species in the Galician forestry and timber industries and the good mechanical properties of its wood. In this study, we investigated how timber stiffness is affected by tree and stand properties, climatic and edaphic characteristics and competition. Area of study: The study was performed in Galicia, north-western Spain.Material and methods: Ten pure and even-aged P. pinaster stands were selected and tree and stand variables and the stress wave velocity of 410 standing trees were measured. A sub-sample of 73 trees, representing the variability in acoustic velocity, were felled and sawed into structural timber pieces (224 which were subjected to a bending test to determine the modulus of elasticity (MOE. Main results: Linear models including wood properties explained more than 97%, 73% and 60% of the observed MOE variability at site, tree and board level, respectively, with acoustic velocity and wood density as the main regressors. Other linear models, which did not include wood density, explained more than 88%, 69% and 55% of the observed MOE variability at site, tree and board level, respectively, with acoustic velocity as the main regressor. Moreover, a classification tree for estimating the visual grade according to standard UNE 56544:2011 was developed. Research highlights: The results have demonstrated the usefulness of acoustic velocity for predicting MOE in standing trees. The use of the fitted equations together with existing dynamic growth models will enable preliminary assessment of timber stiffness in relation to different silvicultural alternatives used with this species.Keywords: stress wave velocity, modulus of elasticity, site index, competition index, stepwise regression, CART.

An Inventory of the Vascular Flora of Fort Greely, Interior Alaska

Science.gov (United States)

2001-02-01

Alnus tenuifolia Nutt. [= Alnus incana (L.) Moench ssp. tenuifolia (Nutt.) Breitung] Alnus viridis Vill. ssp. crispa (Ait.) A. Love & D. Love...Festuca rubra L., in part] Festuca saximontana Rydb. *Festuca vivipara (L.) Smith [= “Festuca vivipara”] Fragaria virginiana Duchesne ssp. glauca...tenuifolia (Nutt.) Breitung] Alnus viridis Vill. ssp. crispa (Ait.) A. Love & D. Love [= Alnus crispa (Ait.) Pursh ssp. crispa] Betula glandulosa Michx. Betula

Floral scent compounds of Amazonian Annonaceae species pollinated by small beetles and thrips.

Science.gov (United States)

Jürgens, A; Webber, A C; Gottsberger, G

2000-11-01

Chemical analysis (GC-MS) yielded a total of 58 volatile compounds in the floral scents of six species of Annonaceae distributed in four genera (Xylopia, Anaxagorea, Duguetia, and Rollinia), Xylopia aromatica is pollinated principally by Thysanoptera and secondarily by small beetles (Nitidulidae and Staphylinidae), whereas the five other species were pollinated by Nitidulidae and Staphylinidae only. Although the six Annonaceae species attract a similar array of pollinator groups, the major constituents of their floral scents are of different biochemical origin. The fragrances of flowers of Anaxagorea brevipes and Anaxagorea dolichocarpa were dominated by esters of aliphatic acids (ethyl 2-methylbutanoate, ethyl 3-methylbutanoate), which were not detected in the other species. Monoterpenes (limonene, p-cymene, alpha-pinene) were the main scent compounds of Duguetia asterotricha, and naphthalene prevailed in the scent of Rollinia insignis flowers. The odors of X. aromatica and Xylopia benthamii flowers were dominated by high amounts of benzenoids (methylbenzoate, 2-phenylethyl alcohol).

Impact of Auditory Integrative Training on Transforming Growth Factor-β1 and Its Effect on Behavioral and Social Emotions in Children with Autism Spectrum Disorder.

Science.gov (United States)

Al-Ayadhi, Laila; Alhowikan, Abdulrahman Mohammed; Halepoto, Dost Muhammad

2018-01-01

To explore the impact of auditory integrative training (AIT) on the inflammatory biomarker transforming growth factor (TGF)-β1 and to assess its effect on social behavior in children with autism spectrum disorder (ASD). In this cross-sectional study, 15 patients (14 males and 1 female) with ASD aged 3-12 years were recruited. All were screened for autism using the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Plasma levels of TGF-β1 were measured in all patients using a sandwich enzyme-linked immunoassay (ELISA) immediately and 1 and 3 months after the AIT sessions. Pre- and post-AIT behavioral scores were also calculated for each child using the Childhood Autism Rating Scale (CARS), the Social Responsiveness Scale (SRS), and the Short Sensory Profile (SSP). Data were analyzed using the Statistical Package for the Social Sciences (SPSS 21.0 for Windows). Plasma levels of TGF-β1 significantly increased to 85% immediately after AIT (20.13 ± 12 ng/mL, p < 0.05), to 95% 1 month after AIT (21.2 ± 11 ng/mL, p < 0.01), and to 105% 3 months after AIT (22.25 ± 16 ng/mL, p < 0.01) compared to before AIT (10.85 ± 8 ng/mL). Results also revealed that behavioral rating scales (CARS, SRS, and SSP) improved in terms of disease severity after AIT. Increased plasma levels of TGF-β1 support the therapeutic effect of AIT on TGF-β1 followed by improvement in social awareness, social cognition, and social communication in children with ASD. Furthermore, TGF-β1 was associated with severity in all scores tested (CARS, SRS, and SSP); if confirmed in studies with larger sample sizes, TGF-β1 may be considered as a marker of ASD severity and to assess the efficacy of therapeutic interventions. © 2018 The Author(s) Published by S. Karger AG, Basel.

The рopulation сomposition of lymphocyte and the rate of infection by by the herpes simplex virus in patients ill with autoimmune autoimmune thyroiditis

Directory of Open Access Journals (Sweden)

E B Kravez

2006-12-01

Full Text Available The objective of the research is the analysis of blood lymphocyte composition and the rate of infection by the herpes simplex virus (HSV, cytomegalovirus (CMV and Epstein-Barr virus (EBV in patients with AIT. Two men and twenty six women (with the average age 44.0 ± 2.3 years ill with the disease for 6.0 ± 2.7 years were examined. 85.7% of the ill were in the euthyroid state, 14.3% were in hypothyroidism. 25% ofthe patients were diagnosed with atrophic AIT, 60,7% got the diagnoses of fibroid and fibronodular AIT and 14.3% got hypertrophic AIT diagnoses. It was found that the course of AIT was accompanied with the increase of the rate of CD20 +-lymphocytes in blood at the normal number of CD3 +-, CD4 +-, CD8 +- и CD56 + cells. The IgG to the HSV was found in 92.9% patients with AIT, to the CMV - in 96.4% cases, to the pre-early antigen (ЕА of CMV (acute infection - in 39.3% patients and to the nuclear antigen of EBV (КА (late past-infection - in 67.6% cases. In two cases we found EBV-IgG to EA and КА simultaneously (late stage of primary EBV-infection or reactivation of its chronic form. It was proved that 39.3% of the patients with AIT associate this disease with acute cytomegalovirus infection.

Allocation to reproduction and relative reproductive costs in two species of dioecious Anacardiaceae with contrasting phenology.

Science.gov (United States)

Matsuyama, Shuhei; Sakimoto, Michinori

2008-06-01

The cost of reproduction in dioecious plants is often female-biased. However, several studies have reported no difference in costs of reproduction between the sexes. In this study, the relative reproductive allocation and costs at the shoot and whole-plant levels were examined in woody dioecious Rhus javanica and R. trichocarpa, in order to examine differences between types of phenophase (i.e. physiological stage of development). Male and female Rhus javanica and R. trichocarpa were sampled and the reproductive and vegetative allocation of the shoot were estimated by harvesting reproductive current-year shoots during flowering and fruiting. Measurements were made of the number of reproductive and total current-year shoots per whole plant, and of the basal area increment (BAI). The numbers of reproductive and total current-year shoots per 1-year-old shoot were counted in order to examine the costs in the following year at the shoot level. A female-biased annual reproductive allocation was found; however, the ratio of reproductive current-year shoots per tree and the BAI did not differ between sexes in Rhus javanica and R. trichocarpa. The percentage of 1-year-old shoots with at least one reproductive current-year shoot was significantly male-biased in R. trichocarpa, but not in R. javanica, indicating that there was a relative cost at the shoot level only in R. trichocarpa. The female-biased leaf mass per shoot, an indicator of compensation for costs, was only found in R. javanica. Relative reproductive costs at the shoot level were detected in Rhus trichocarpa, which has simultaneous leafing and flowering, but not in R. javanica, which has leafing followed by flowering. However, the costs for the whole-plant level were diminished in both species. The results suggest that the phenophase type may produce the different costs for R. javanica and R. trichocarpa through the development of a compensation mechanism.

In vitro microrhizome production in Decalepis hamiltonii

African Journals Online (AJOL)

SAM

2014-03-12

Mar 12, 2014 ... Micro-rhizomes have been induced in Curcuma aromatica, Curcuma longa and the efficiency of microrhizome formation was found to be determined by the concentration of cytokinins, sucrose and coconut milk. (Naik and Naik, 2006). Production of microrhizomes in vitro has many advantages compared to ...

interactive effect of cowpea variety, dose and exposure time

African Journals Online (AJOL)

ACSS

Callosobruchus maculatus has for years remained a serious menace in cowpea in Sub-Sahara Africa. The objective of this study was to investigate the effect of genotypic cowpea (Vigna unguiculata (L.) Walp) varieties, time and dose on C. maculatus exposed to powders of Piper guineense and Eugenia aromatica.

EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy.

Science.gov (United States)

Pajno, G B; Fernandez-Rivas, M; Arasi, S; Roberts, G; Akdis, C A; Alvaro-Lozano, M; Beyer, K; Bindslev-Jensen, C; Burks, W; Ebisawa, M; Eigenmann, P; Knol, E; Nadeau, K C; Poulsen, L K; van Ree, R; Santos, A F; du Toit, G; Dhami, S; Nurmatov, U; Boloh, Y; Makela, M; O'Mahony, L; Papadopoulos, N; Sackesen, C; Agache, I; Angier, E; Halken, S; Jutel, M; Lau, S; Pfaar, O; Ryan, D; Sturm, G; Varga, E-M; van Wijk, R G; Sheikh, A; Muraro, A

2018-04-01

Food allergy can result in considerable morbidity, impairment of quality of life, and healthcare expenditure. There is therefore interest in novel strategies for its treatment, particularly food allergen immunotherapy (FA-AIT) through the oral (OIT), sublingual (SLIT), or epicutaneous (EPIT) routes. This Guideline, prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Task Force on Allergen Immunotherapy for IgE-mediated Food Allergy, aims to provide evidence-based recommendations for active treatment of IgE-mediated food allergy with FA-AIT. Immunotherapy relies on the delivery of gradually increasing doses of specific allergen to increase the threshold of reaction while on therapy (also known as desensitization) and ultimately to achieve post-discontinuation effectiveness (also known as tolerance or sustained unresponsiveness). Oral FA-AIT has most frequently been assessed: here, the allergen is either immediately swallowed (OIT) or held under the tongue for a period of time (SLIT). Overall, trials have found substantial benefit for patients undergoing either OIT or SLIT with respect to efficacy during treatment, particularly for cow's milk, hen's egg, and peanut allergies. A benefit post-discontinuation is also suggested, but not confirmed. Adverse events during FA-AIT have been frequently reported, but few subjects discontinue FA-AIT as a result of these. Taking into account the current evidence, FA-AIT should only be performed in research centers or in clinical centers with an extensive experience in FA-AIT. Patients and their families should be provided with information about the use of FA-AIT for IgE-mediated food allergy to allow them to make an informed decision about the therapy. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

The European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI): A paediatric assessment.

Science.gov (United States)

Rodríguez Del Río, Pablo; Vidal, Carmen; Just, Jocelyne; Tabar, Ana I; Sanchez-Machin, Inmaculada; Eberle, Peter; Borja, Jesus; Bubel, Petra; Pfaar, Oliver; Demoly, Pascal; Calderón, Moises A

2017-02-01

Safety data on 'real-life' allergen immunotherapy (AIT) in children and adolescents is usually extrapolated from studies in adults. Patients aged 18 or under initiating aeroallergen AIT were evaluated in a prospective European survey. Patient profiles and systemic reactions (SRs) were recorded. Descriptive, univariate and multivariate analyses were used to identify risk factors for SRs. A total of 1563 patients (mean ± SD age: 11.7 ± 3.9 years; rhinitis: 93.7%; asthma: 61.5%; polysensitization: 62.5%) and 1578 courses of AIT were assessed. Single-allergen AIT was administered in 89.5% of cases (n = 1412; mites: 49%; grass pollen: 25.8%; tree pollen: 8.7%; Alternaria: 4.6%; dander: 0.8%; weed pollen: 0.6%). Subcutaneous AIT (SCIT) was used in 71.4% (n = 1127) of the treatments, including 574 (50.9%) with natural extracts. Sublingual AIT (SLIT) was used for the remaining 451 treatments (drops: 73.8%; tablets: 26.2%). The mean ± SD follow-up period was 12.9 ± 3.3 months. The estimated total number of doses was 19,669 for SCIT and 131,550 for SLIT. Twenty-four patients (1.53%) experienced 29 SRs. Respiratory (55.7%) and skin symptoms (37.9%) were most frequent. Anaphylaxis was diagnosed in 3 SRs (10.3%), and adrenaline was administered in 2 of these cases. In a univariate analysis, the risk of SRs was lower in mite-sensitized patients and higher in cases of pollen polysensitization (>3), grass pollen extracts and the use of natural extracts (vs. allergoids). In a real-life paediatric setting, AIT is safe. SRs are infrequent and generally not severe. Pollen polysensitization, grass pollen extracts and natural extracts (vs. allergoids) were risk factors for AIT-associated SRs. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Factors affecting cone production in Pinus pinaster Ait.: lack of growth-reproduction trade-offs but significant effects of climate and tree and stand characteristics

Energy Technology Data Exchange (ETDEWEB)

Bravo, F.; Maguire, D.A.; González-Martínez, S.G.

2017-11-01

Aim of study: Our main goal is to determine the relationship between cone production and radial growth in Pinus pinaster Ait. under different climatic conditions across the Iberian Peninsula. Area of study: Coca Intensive Sampling Plateau, Northern Plateau (Spain). Material and methods: Cone counts were conducted on an intensive monitoring plot in Coca (North-Central Spain) during the years 2000, 2006 and 2007. A ZIP (zero-inflated Poisson) model was adjusted for simultaneously estimating the probability of obtaining crop cones and its amount. The Northern Atlantic Oscillation (NAO) index was used as explanatory variable, together with a wide variety of tree and local stand variables. Climate (as evaluated by NAO), local stand density (here estimated from the six nearest trees), tree size and vigor, competition and growth efficiency significantly influenced both occurrence and intensity of cone production. Main results: ZIP models for predicting reproductive effort seems an adequate tool to predict reproductive responses to climatic fluctuations and the resulting future species distribution in the face of climate change, as well as to identify silviculture actions that would promote reproductive success in naturally-regenerated stands, list and discuss relevant results (including numeric values of experimental results). Research highlights: Climate, stand density and tree conditions (size and vigor, competition and growth efficiency) influence significantly both cone occurrence and intensity of fruiting as shown by a ZIP model. As the climate variables included in the model (based on Northern Atlantic Oscillation, NAO) are general and easily obtained, the proposed model has practical applicability to predicting Pinus pinaster cone production in the Iberian Peninsula.

Factors affecting cone production in Pinus pinaster Ait.: lack of growth-reproduction trade-offs but significant effects of climate and tree and stand characteristics

Directory of Open Access Journals (Sweden)

Felipe Bravo

2017-10-01

Full Text Available Aim of study: Our main goal is to determine the relationship between cone production and radial growth in Pinus pinaster Ait. under different climatic conditions across the Iberian Peninsula. Area of study: Coca Intensive Sampling Plateau, Northern Plateau (Spain. Material and methods: Cone counts were conducted on an intensive monitoring plot in Coca (North-Central Spain during the years 2000, 2006 and 2007. A ZIP (zero-inflated Poisson model was adjusted for simultaneously estimating the probability of obtaining crop cones and its amount. The Northern Atlantic Oscillation (NAO index was used as explanatory variable, together with a wide variety of tree and local stand variables. Climate (as evaluated by NAO, local stand density (here estimated from the six nearest trees, tree size and vigor, competition and growth efficiency significantly influenced both occurrence and intensity of cone production. Main results: ZIP models for predicting reproductive effort seems an adequate tool to predict reproductive responses to climatic fluctuations and the resulting future species distribution in the face of climate change, as well as to identify silviculture actions that would promote reproductive success in naturally-regenerated stands, list and discuss relevant results (including numeric values of experimental results. Research highlights: Climate, stand density and tree conditions (size and vigor, competition and growth efficiency influence significantly both cone occurrence and intensity of fruiting as shown by a ZIP model. As the climate variables included in the model (based on Northern Atlantic Oscillation, NAO are general and easily obtained, the proposed model has practical applicability to predicting Pinus pinaster cone production in the Iberian Peninsula.

Factors affecting cone production in Pinus pinaster Ait.: lack of growth-reproduction trade-offs but significant effects of climate and tree and stand characteristics

International Nuclear Information System (INIS)

Bravo, F.; Maguire, D.A.; González-Martínez, S.G.

2017-01-01

Aim of study: Our main goal is to determine the relationship between cone production and radial growth in Pinus pinaster Ait. under different climatic conditions across the Iberian Peninsula. Area of study: Coca Intensive Sampling Plateau, Northern Plateau (Spain). Material and methods: Cone counts were conducted on an intensive monitoring plot in Coca (North-Central Spain) during the years 2000, 2006 and 2007. A ZIP (zero-inflated Poisson) model was adjusted for simultaneously estimating the probability of obtaining crop cones and its amount. The Northern Atlantic Oscillation (NAO) index was used as explanatory variable, together with a wide variety of tree and local stand variables. Climate (as evaluated by NAO), local stand density (here estimated from the six nearest trees), tree size and vigor, competition and growth efficiency significantly influenced both occurrence and intensity of cone production. Main results: ZIP models for predicting reproductive effort seems an adequate tool to predict reproductive responses to climatic fluctuations and the resulting future species distribution in the face of climate change, as well as to identify silviculture actions that would promote reproductive success in naturally-regenerated stands, list and discuss relevant results (including numeric values of experimental results). Research highlights: Climate, stand density and tree conditions (size and vigor, competition and growth efficiency) influence significantly both cone occurrence and intensity of fruiting as shown by a ZIP model. As the climate variables included in the model (based on Northern Atlantic Oscillation, NAO) are general and easily obtained, the proposed model has practical applicability to predicting Pinus pinaster cone production in the Iberian Peninsula.

Antihypertensive activity of 80% methanol seed extract of Calpurnia aurea (Ait.) Benth. subsp. aurea (Fabaceae) is mediated through calcium antagonism induced vasodilation.

Science.gov (United States)

Getiye, Yohannes; Tolessa, Tesfaye; Engidawork, Ephrem

2016-08-02

Calpurnia aurea (Ait.) Benth. subsp. aurea (CASA) (Fabaceae) seeds are used to treat hypertension in Ethiopian folklore medicine, particularly by Shinasha, Agew-awi and Amhara people in northwest Ethiopia. However, the claim has so far not been substantiated scientifically. The study was conducted to evaluate the antihypertensive activity of 80% methanol extract of CASA in animal model of hypertension as well as its vasorelaxant effect and possible underlying mechanisms in isolated guinea pig aorta. Hypotensive and antihypertensive effect of CASA extract was determined in vivo through the intravenous (iv) route in normotensive and hypertensive anesthetized rats using 2-kidney-1-clip (2K1C) rat model. Ex vivo, guinea pig thoracic aortic rings were isolated and suspended in organ bath, and the vasodepressor effects as well as the mechanism of action of the extract were studied by means of isometric tension recording experiments. The blood pressure fell dose-dependently and significantly in renal hypertensive and normotensive rats following i.v. administration, suggesting that the hydroalcoholic extract possesses hypotensive and antihypertensive effects. The extract also caused a dose-dependent relaxation of aorta pre-contracted with KCl at a concentration of 5-250mg/L, with a maximum relaxation of 92.1% achieved at 250mg/L. The relaxation mechanism was found to be independent of the muscarinic receptors, histamine receptors, ATP dependent K(+) channels, cyclooxygenase enzymes, cGMP/NO pathway and the endothelium system. The extract caused rightward shift of the Ca(++) dose-response curves, similar to that caused by verapamil, indicating that it produced vasorelaxation by inhibiting extracellular Ca(2+) influx. The findings demonstrate that the plant is endowed with antihypertensive effect, providing evidence for its traditional use. The effect may be, at least in part, due to dilation of blood vessels through blockage of Ca(2+) channels. Copyright © 2016 Elsevier

Microwave-assisted extraction and ultrasonic extraction to determine polycyclic aromatic hydrocarbons in needles and bark of Pinus pinaster Ait. and Pinus pinea L. by GC-MS.

Science.gov (United States)

Ratola, Nuno; Lacorte, Sílvia; Barceló, Damià; Alves, Arminda

2009-01-15

Two different extraction strategies (microwave-assisted extraction (MAE) and ultrasonic extraction (USE)) were tested in the extraction of the 16 US Environmental Protection Agency (EPA) polycyclic aromatic hydrocarbons (PAHs) from pine trees. Extraction of needles and bark from two pine species common in the Iberian Peninsula (Pinus pinaster Ait. and Pinus pinea L.) was optimized using two amounts of sample (1g and 5 g) and two PAHs spiking levels (20 ng/g and 100 ng/g). In all cases, the clean-up procedure following extraction consisted in solid-phase extraction (SPE) with alumina cartridges. Quantification was done by gas chromatography (GC) with mass spectrometry (MS), using five deuterated PAH surrogate standards as internal standards. Limits of detection were globally below 0.2 ng/g. The method was robust for the matrices studied regardless of the extraction procedures. Recovery values between 70 and 130% were reached in most cases, except for high molecular weight PAHs (indeno[1,2,3-cd]pyrene, dibenzo[a,h]anthracene and benzo[ghi]perylene). A field study with naturally contaminated samples from eight sites (four in Portugal and four in Catalonia, Spain) showed that needles are more suitable biomonitors for PAHs, yielding concentrations from 2 to 17 times higher than those found in bark. The levels varied according to the sampling site, with the sum of the individual PAH concentrations between 213 and 1773 ng/g (dry weight). Phenanthrene was the most abundant PAH, followed by fluoranthene, naphthalene and pyrene.

Allergen immunotherapy for IgE-mediated food allergy

DEFF Research Database (Denmark)

Nurmatov, Ulugbek; Dhami, S; Arasi, S.

2017-01-01

Background: The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated Food Allergy. To inform the development of clinical recommendations, we sought to critically assess evidence on the effectiveness, safety and cost-effectiveness...... economic analyses. Conclusions: AIT may be effective in raising the threshold of reactivity to a range of foods in children with IgE-mediated food allergy whilst receiving (i.e. desensitization) and post-discontinuation of AIT. It is, however, associated with a modest increased risk in serious systemic...... adverse reactions and a substantial increase in minor local adverse reactions. More data are needed in relation to adults, long term effects, the impact on QoL and the cost-effectiveness of AIT....

Advanced information technology: Building stronger databases

Energy Technology Data Exchange (ETDEWEB)

Price, D. [Lawrence Livermore National Lab., CA (United States)

1994-12-01

This paper discusses the attributes of the Advanced Information Technology (AIT) tool set, a database application builder designed at the Lawrence Livermore National Laboratory. AIT consists of a C library and several utilities that provide referential integrity across a database, interactive menu and field level help, and a code generator for building tightly controlled data entry support. AIT also provides for dynamic menu trees, report generation support, and creation of user groups. Composition of the library and utilities is discussed, along with relative strengths and weaknesses. In addition, an instantiation of the AIT tool set is presented using a specific application. Conclusions about the future and value of the tool set are then drawn based on the use of the tool set with that specific application.

EAACI Guidelines on Allergen Immunotherapy

DEFF Research Database (Denmark)

Halken, Susanne; Larenas-Linnemann, Desiree; Roberts, Graham

2017-01-01

Allergic diseases are common and frequently coexist. Allergen immunotherapy (AIT) is a disease-modifying treatment for IgE-mediated allergic disease with effects beyond cessation of AIT that may include important preventive effects. The European Academy of Allergy and Clinical Immunology (EAACI) ...... of allergic co-morbidities in those with other allergic conditions. Evidence for the preventive potential of AIT as disease modifying treatment exists but there is an urgent need for more high-quality clinical trials....

Applied analysis of lacquer films based on pyrolysis-gas chromatography/mass spectrometry.

Science.gov (United States)

Lu, Rong; Kamiya, Yukio; Miyakoshi, Tetsuo

2006-09-15

Ancient lacquer film, a Nanban lacquer film, an old lacquer-ware object imported from an Asian country, and the Baroque and Rococo lacquer films were analyzed by pyrolysis-gas chromatography/mass spectrometry. Compared with the results of the natural lacquer film, it was revealed that the ancient lacquer film and Nanban lacquer film were made from Rhus vernicifera, and the old lacquer-ware imported from an Asian country was made from Melanorrhoea usitata. However, the Baroque and Rococo lacquer films obtained from the Doerner Institute in Munich, Germany were made from natural resins. 3-Pentadecylcatechol (MW=320) (urushiol), 3-heptadecylcatechol (MW=348) (laccol), and 4-heptadecylcatechol (MW=348) (thitsiol) were the main products of the pyrolysis of R. vernicifera, Rhus succedanea, and M. usitata.

Urbane spil

DEFF Research Database (Denmark)

Løssing, Tobias

2006-01-01

PhD afhandling: 1: Urbane spil 2: [brand TILST] - den nye forstad. 3: 6400:Kollision - udstilling på Sønderborg Slot 2001 4: 4: [0.2:Kollision] - Charlottenborgs Forårsudstilling 2002 5: Havnen på spil - debatten om de bynære havnearealer i Århus 2002-2004 Manual - uddybet guide til PhD-projektet......PhD afhandling: 1: Urbane spil 2: [brand TILST] - den nye forstad. 3: 6400:Kollision - udstilling på Sønderborg Slot 2001 4: 4: [0.2:Kollision] - Charlottenborgs Forårsudstilling 2002 5: Havnen på spil - debatten om de bynære havnearealer i Århus 2002-2004 Manual - uddybet guide til Ph......D-projektet Urbane spil Se også www.urbanespil.dk...

77 FR 4800 - Notice of Petition for Waiver of Hussmann From the Department of Energy Commercial Refrigerator...

Science.gov (United States)

2012-01-31

... amount and method of merchandising the food product varies which results in a wide range of AIT). Whole... of merchandising the food product varies which results in a wide range of AIT). Whole, uncut fresh...

Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract

Directory of Open Access Journals (Sweden)

Chihiro Tohda

2006-01-01

Full Text Available We aimed to compare the anti-inflammatory activities of six species of Curcuma drugs using adjuvant arthritis model mice. When orally administered 1 day before the injection of adjuvant, the methanol extract of Curcuma phaeocaulis significantly inhibited paw swelling and the serum haptoglobin concentration in adjuvant arthritis mice. Also when orally administered 1 day after the injection of adjuvant, the methanol extract of Curcuma phaeocaulis significantly inhibited paw swelling. Other Curcuma species (Curcuma longa, Curcuma wenyujin, Curcuma kwangsiensis, Curcuma zedoaria and Curcuma aromatica had no significant inhibitory effects on adjuvant-induced paw swelling. Cyclooxygenase (COX-2 activity was significantly inhibited by the methanol extract of C. phaeocaulis. Curcuminoids' (curcumin, bis-demethoxycurcumin and demethoxycurcumin were rich in C. longa, but less in C. phaeocaulis and C. aromatica, not in C. wenyujin, C. kwangsiensis and C. zedoaria, suggesting that curcuminoids' contents do not relate to inhibition of arthritis swelling. Therefore, C. phaeocaulis may be a useful drug among Curcuma species for acute inflammation, and the active constituents of C. phaeocaulis are not curcuminoids.

The effects of nonlinear resistance and aerobic interval training on serum levels of apelin and insulin resistance in middle-aged obese men

Directory of Open Access Journals (Sweden)

Mahmoud Nikseresht

2015-08-01

Conclusion: The practical applications indicate that obese men can use both AIT and NRT exercise programs to reduce insulin resistance. However, the AIT may have better beneficial effects (as indicated by apelin-13 compared to NRT.

Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma.

Science.gov (United States)

Aguilar-Pimentel, Antonio; Graessel, Anke; Alessandrini, Francesca; Fuchs, Helmut; Gailus-Durner, Valerie; Hrabě de Angelis, Martin; Russkamp, Dennis; Chaker, Adam; Ollert, Markus; Blank, Simon; Gutermuth, Jan; Schmidt-Weber, Carsten B

2017-01-01

Allergen-specific immunotherapy (AIT) is the only curative treatment for type-1 allergies, but sometimes shows limited therapeutic response as well as local and systemic side effects. Limited control of local inflammation and patient symptoms hampers its widespread use in severe allergic asthma. Our aim was to evaluate whether AIT is more effective in suppression of local inflammation if performed under the umbrella of short-term non-specific immunomodulation using a small molecule inhibitor of JAK pathways. In C57BL/6J mice, a model of ovalbumin (OVA)-induced allergic airway inflammation and allergen-specific immunotherapy was combined with the administration of Tofacitinib (TOFA, a FDA-approved JAK inhibitor) from 48 hours prior to 48 hours after therapeutic OVA-injection. The effect of TOFA on human FOXP3+CD4+ T cells was studied in vitro. AIT combined with short-term TOFA administration was significantly more effective in suppressing total cell and eosinophil infiltration into the lung, local cytokine production including IL-1β and CXCL1 and showed a trend for the reduction of IL-4, IL-13, TNF-α and IL-6 compared to AIT alone. Furthermore, TOFA co-administration significantly reduced systemic IL-6, IL-1β and OVA-specific IgE levels and induced IgG1 to the same extent as AIT alone. Additionally, TOFA enhanced the induction of human FOXP3+CD4+ T cells. This proof of concept study shows that JAK inhibition did not inhibit tolerance induction, but improved experimental AIT at the level of local inflammation. The improved control of local inflammation might extend the use of AIT in more severe conditions such as polyallergy, asthma and high-risk patients suffering from mastocytosis or anaphylaxis.

Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma.

Directory of Open Access Journals (Sweden)

Antonio Aguilar-Pimentel

Full Text Available Allergen-specific immunotherapy (AIT is the only curative treatment for type-1 allergies, but sometimes shows limited therapeutic response as well as local and systemic side effects. Limited control of local inflammation and patient symptoms hampers its widespread use in severe allergic asthma.Our aim was to evaluate whether AIT is more effective in suppression of local inflammation if performed under the umbrella of short-term non-specific immunomodulation using a small molecule inhibitor of JAK pathways.In C57BL/6J mice, a model of ovalbumin (OVA-induced allergic airway inflammation and allergen-specific immunotherapy was combined with the administration of Tofacitinib (TOFA, a FDA-approved JAK inhibitor from 48 hours prior to 48 hours after therapeutic OVA-injection. The effect of TOFA on human FOXP3+CD4+ T cells was studied in vitro.AIT combined with short-term TOFA administration was significantly more effective in suppressing total cell and eosinophil infiltration into the lung, local cytokine production including IL-1β and CXCL1 and showed a trend for the reduction of IL-4, IL-13, TNF-α and IL-6 compared to AIT alone. Furthermore, TOFA co-administration significantly reduced systemic IL-6, IL-1β and OVA-specific IgE levels and induced IgG1 to the same extent as AIT alone. Additionally, TOFA enhanced the induction of human FOXP3+CD4+ T cells.This proof of concept study shows that JAK inhibition did not inhibit tolerance induction, but improved experimental AIT at the level of local inflammation. The improved control of local inflammation might extend the use of AIT in more severe conditions such as polyallergy, asthma and high-risk patients suffering from mastocytosis or anaphylaxis.

Allergen immunotherapy: clinical and practical education of Italian trainees in allergy and clinical immunology schools.

Science.gov (United States)

Ridolo, E; Incorvaia, C; Senna, G E; Montagni, M; Olivieri, E; Canonica, G W

2013-10-01

We performed a survey, based on a questionnaire including 20 items, submitted anonymously to Italian trainees in Allergology and Clinical Immunology, in order to obtain information about their specific allergen immunotherapy (AIT) practices. The questionnaire was sent to 40 trainees, who had attended the last two years of the training course. Thirty-four subjects (mean age: 27 years, 65% females) adequately completed the survey. The answers to the questionnaire showed that only 60% of the training programs included lectures on AIT. Among the trainees using AIT, only 40% declared being able to prescribe it independently, while 60% were guided by a tutor. Of the trainees who were able to prescribe AIT autonomously, 60% were familiar with both routes of administration, i.e. subcutaneous (SCIT) and sublingual immunotherapy (SLIT), while 25% of these used only SLIT. In 80% of the training institutions involved, the trainees could attend a dedicated AIT outpatient ward for SCIT administration; only 40% administered AIT personally, and in half of these cases, they were guided by a tutor. Only 70% of trainees had experience in the follow-up of patients still under treatment and of patients who had completed treatment. Analysis of the answers obtained for questions on venom immunotherapy (VIT) showed that, in 90% of cases, the trainees attended a dedicated outpatients ward where VIT is administered, but with a role limited to observation/cooperation. Only 30% were involved in the follow-up of patients who were under treatment or who had completed VIT. Only 20% of the trainees felt confident enough about VIT to prescribe this treatment independently, 80% knew there were several administration protocols, and the majority prescribed products from three different manufacturers. These findings suggest that there is significant room for improving the instructions provided regarding allergology and clinical immunology to trainees in Italy with respect to AIT.

High- and moderate-intensity aerobic exercise and excess post-exercise oxygen consumption in men with metabolic syndrome.

Science.gov (United States)

Larsen, I; Welde, B; Martins, C; Tjønna, A E

2014-06-01

Physical activity is central in prevention and treatment of metabolic syndrome. High-intensity aerobic exercise can induce larger energy expenditure per unit of time compared with moderate-intensity exercise. Furthermore, it may induce larger energy expenditure at post-exercise recovery. The aim of this study is to compare the excess post-exercise oxygen consumption (EPOC) in three different aerobic exercise sessions in men with metabolic syndrome. Seven men (age: 56.7 ± 10.8) with metabolic syndrome participated in this crossover study. The sessions consisted of one aerobic interval (1-AIT), four aerobic intervals (4-AIT), and 47-min continuous moderate exercise (CME) on separate days, with at least 48 h between each test day. Resting metabolic rate (RMR) was measured pre-exercise and used as baseline value. EPOC was measured until baseline metabolic rate was re-established. An increase in O2 uptake lasting for 70.4 ± 24.8 min (4-AIT), 35.9 ± 17.3 min (1-AIT), and 45.6 ± 17.3 min (CME) was observed. EPOC were 2.9 ± 1.7 L O2 (4-AIT), 1.3 ±  .1 L O2 (1-AIT), and 1.4 ± 1.1 L O2 (CME). There were significant differences (P exercise intensity has a significant positive effect on EPOC in men with metabolic syndrome. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Ultra-short-course booster is effective in recurrent grass pollen-induced allergic rhinoconjunctivitis.

Science.gov (United States)

Pfaar, O; Lang, S; Pieper-Fürst, U; Astvatsatourov, A; Gerich, F; Klimek, L; Kramer, M F; Reydelet, Y; Shah-Hosseini, K; Mösges, R

2018-01-01

A relevant proportion of allergic rhinoconjunctivitis (ARC) patients experience recurrent symptoms after successfully completing allergen immunotherapy (AIT). This prospective, controlled, noninterventional study used internationally standardized instruments to determine the clinical effects of a preseasonal, ultra-short-course booster AIT on clinical outcome parameters. This two-arm study included patients aged ≥12 years with recurrent grass pollen-induced seasonal AR who had completed a successful course of any grass pollen AIT at least 5 years before enrolment. Overall, 56 patients received one preseasonal short-course booster AIT using tyrosine-absorbed grass pollen allergoids containing the adjuvant monophosphoryl lipid A (MPL ® ); 51 control patients received symptomatic medication. The combined symptom and medication score (CSMS) was recorded in the (peak) grass pollen season. Furthermore, concomitant (antiallergic) medication use, the patients' state of health, Mini Rhinoconjunctivitis Quality of Life Questionnaire (MiniRQLQ) results and safety/tolerability of the treatment were assessed. The CSMS in the peak grass pollen season was significantly lower in the booster AIT group (Δ=38.4%, Pallergoids containing the adjuvant MPL ® effectively prevents re-occurrence of symptoms in patients with grass pollen-induced ARC. © 2017 The Authors. Allergy Published by John Wiley & Sons Ltd.

Poison Ivy Dermatitis

Science.gov (United States)

... than the other two. Poison ivy clings to tree trunks and other vertical surfaces with hair-like ... urushiol". These are called Rhus plants after the old scientific name (it was changed to toxidendron). A ...

One of my kind?

DEFF Research Database (Denmark)

Christensen, Mette Vedsgaard

2010-01-01

Language attitude studies are of great value to sociolinguistics – they complement studies of linguistic variation and provide studies of linguistic change with valuable insights and explanations. Hence, understanding how language variation is perceived among the members of a speech community...... presents results from a language recognition study carried out in Århus and Copenhagen. By employing the methodology from language attitude research, the study aims at investigating how different groups of adolescents recognize and perceive different speech styles....... is an important part of the study of linguistic variation and its social meaning. Recent studies of language and ethnicity in Denmark show that salient linguistic traits are common to minority background speakers in both Århus and Copenhagen, pointing to the existence of an ethnic variety of Danish. This chapter...

Pronuncia e altre abilità linguistiche

DEFF Research Database (Denmark)

Pierucci, Giulia

In questa sede si intende illustrare e discutere alcuni interventi didattici nell’ambito del progetto di ricerca “ Dai suoni alla lingua in uso: sviluppare consapevolezza fonologica per favorire l’acquisizione e l’interazione nell’apprendimento dell’italiano LS a livelli iniziali”, presentato...... in occasione del X Congresso degli Italianisti Scandinavi a Reykjavik nel giugno 2013. In particolare verranno proposti percorsi didattici finalizzati all’acquisizione della competenza e consapevolezza fonologica in relazione allo sviluppo delle altre abilità linguistiche che saranno state sperimentate...... in classe, nei corsi di laurea in italiano dell’Università di Århus, con gruppi principianti e non. Si illustreranno anche interventi seminariali rivolti a insegnanti di lingua straniera nelle scuole superiori danesi, in programma per gennaio presso l’Universitá di Århus. Saranno presi in visione video e...

Comparative analysis of antibacterial activity of povidone iodine and homoeopathic mother tinctures as antiseptics

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Muhammad Mohsin Zaman

2016-01-01

Conclusion: This study confirms the antibacterial activity and more effectiveness of Thuja occidentalis and Rhus glabra mother tinctures than povidone iodine. The other tested mother tinctures also have antibacterial activity against tested bacteria, except Echinacea.

Correlation of hormonal and cytokines regulation in case of autoimmune thyroiditis

Directory of Open Access Journals (Sweden)

Victoria V. Zdor

2017-10-01

Full Text Available Background. Studied immune aspects of the pathogenesis of autoimmune thyroiditis (AIT, which occupies the first place among human autoimmune pathologies. Treatment of the disease is based on thyroid hormones (TH replacement therapy. TH are today considered to be super antigens in autoimmune inflammation of the thyroid gland. Aims. On the basis of complex assessment of hormonal and immunological markers (TSH, TH, Treg, the Th1-, Th2-, Th17-marker cytokines with a research of possible interrelations of their indicators at patients with various clinical options of a current of AIT initially and against the background of replacement therapy of TH to define differences in functional activity of various types of immunocompetent cages depending on weight of inflammatory process for forecasting of a further clinical current of AIT, optimization of protocols of therapy and timely correction of strategy of treatment. Methods. In a prospective study, patients with AIT were evaluated for serum levels of cytokines and their receptors before initiating TH replacement therapy and on treatment by means of the ELISA modern methods with immuneсhemiluminescence and electroсhemiluminescence ways of detection. Results. Patients suffering from AIT showed an excess production of Th1-, Th2-, Th17- and Tregs marker cytokines with a deficiency of TGF-β1, closely connected with autoimmune hypothyroidism severity. Under pressure of TH therapy the indices of most cytokines decreased or improved, with the exception of IL-6, IL-8, IL-2, IFN-g, TNF-α. The greatest variations from the normal range were recorded in the complicated hypothyroidism. Conclusions. High serum TNF-α level in the onset of the disease is an important marker for the unfavourable AIT course and a predictor of hormone replacement therapy in case of its subclinical course. Safety indexes of functional thyroid epithelium are systemic levels of IL-8 and IL-22, their dynamic reduction in blood serum is an

Allergen immunotherapy for allergic rhinoconjunctivitis

DEFF Research Database (Denmark)

Dhami, Sangeeta; Nurmatov, Ulugbek; Roberts, Graham

2016-01-01

BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Allergic Rhinoconjunctivitis. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT...

Challenges in the implementation of EAACI guidelines on allergen immunotherapy

DEFF Research Database (Denmark)

Bonertz, A; Roberts, G C; Hoefnagel, M

2018-01-01

Regulatory approaches for allergen immunotherapy (AIT) products and the availability of high-quality AIT products are inherently linked to each other. While allergen products are available in many countries across the globe, their regulation is very heterogeneous. First, we describe the regulator...

Allergen immunotherapy for allergic rhinoconjunctivitis : protocol for a systematic review

NARCIS (Netherlands)

Dhami, Sangeeta; Nurmatov, Ulugbek; Roberts, Graham; Pfaar, Oliver; Muraro, Antonella; Ansotegui, Ignacio J; Calderon, Moises; Cingi, Cemal; Demoly, Pascal; Durham, Stephen; van Wijk, Ronald Gerth; Halken, Susanne; Hamelmann, Eckard; Hellings, Peter; Jacobsen, Lars; Knol, Edward; Linnemann, Desiree Larenas; Lin, Sandra; Maggina, Vivian; Oude-Elberink, Hanneke; Pajno, Giovanni; Panwankar, Ruby; Pastorello, Elideanna; Pitsios, Constantinos; Rotiroti, Giuseppina; Timmermans, Frans; Tsilochristou, Olympia; Varga, Eva-Maria; Wilkinson, Jamie; Williams, Andrew; Worm, Margitta; Zhang, Luo; Sheikh, Aziz

2016-01-01

BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Allergic Rhinoconjunctivitis. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT

The value of pre- and co-seasonal sublingual immunotherapy in pollen-induced allergic rhinoconjunctivitis

DEFF Research Database (Denmark)

Demoly, Pascal; Calderon, Moises A; Casale, Thomas B

2015-01-01

Allergen immunotherapy (AIT) is a guidelines-approved, disease-modifying treatment option for respiratory allergies, including allergic rhinitis (AR) induced by pollen. The various AIT regimens employed to date in pollen-induced AR can be classified as continuous (i.e. year-round) or discontinuou...

Allergen immunotherapy for allergic asthma: Protocol for a systematic review

NARCIS (Netherlands)

Dhami, S. (Sangeeta); Nurmatov, U. (Ulugbek); I. Agache; S. Lau (Susanne); Muraro, A. (Antonella); M. Jutel (M.); G. Roberts; C.A. Akdis; M. Bonini (Matteo); M. Calderon (Moises); T.B. Casale (Thomas); Cavkaytar, O. (Ozlem); L. Cox (Linda); P. Demoly; Flood, B. (Breda); Hamelmann, E. (Eckard); Izuhara, K. (Kenji); O. Kalayci; J. Kleine-Tebbe (Jörg); A. Nieto (Antonio); N. Papadopoulos; O. Pfaar (Oliver); L. Rosenwasser (Lanny); D. Ryan (Dermot); C.B. Schmidt-Weber; S.J. Szefler; U. Wahn (Ulrich); R. Gerth van Wijk (Roy); Wilkinson, J. (Jamie); A. Sheikh (Aziz)

2016-01-01

textabstractBackground: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for Allergic Asthma. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in the management of

Allergen immunotherapy for insect venom allergy : protocol for a systematic review

NARCIS (Netherlands)

Dhami, Sangeeta; Nurmatov, Ulugbek; Varga, Eva-Maria; Sturm, Gunter; Muraro, Antonella; Akdis, Cezmi A.; Antolin-Amerigo, Dario; Bilo, M. Beatrice; Bokanovic, Danijela; Calderon, Moises A.; Cichocka-Jarosz, Ewa; Oude Elberink, Joanna N. G.; Gawlik, Radoslaw; Jakob, Thilo; Kosnik, Mitja; Lange, Joanna; Mingomataj, Ervin; Mitsias, Dimitris I.; Mosbech, Holger; Pfaar, Oliver; Pitsios, Constantinos; Pravettoni, Valerio; Roberts, Graham; Rueeff, Franziska; Sin, Betul Ayse; Sheikh, Aziz

2016-01-01

Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Insect Venom Allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in the

Effects of 6-month aerobic interval training on skeletal muscle metabolism in middle-aged metabolic syndrome patients

DEFF Research Database (Denmark)

Guadalupe-Grau, A; Fernández-Elías, V E; Ortega, J F

2018-01-01

Aerobic interval training (AIT) improves the health of metabolic syndrome patients (MetS) more than moderate intensity continuous training. However, AIT has not been shown to reverse all metabolic syndrome risk factors, possibly due to the limited duration of the training programs. Thus, we...

An Interval Type-2 Fuzzy System with a Species-Based Hybrid Algorithm for Nonlinear System Control Design

Directory of Open Access Journals (Sweden)

Chung-Ta Li

2014-01-01

Full Text Available We propose a species-based hybrid of the electromagnetism-like mechanism (EM and back-propagation algorithms (SEMBP for an interval type-2 fuzzy neural system with asymmetric membership functions (AIT2FNS design. The interval type-2 asymmetric fuzzy membership functions (IT2 AFMFs and the TSK-type consequent part are adopted to implement the network structure in AIT2FNS. In addition, the type reduction procedure is integrated into an adaptive network structure to reduce computational complexity. Hence, the AIT2FNS can enhance the approximation accuracy effectively by using less fuzzy rules. The AIT2FNS is trained by the SEMBP algorithm, which contains the steps of uniform initialization, species determination, local search, total force calculation, movement, and evaluation. It combines the advantages of EM and back-propagation (BP algorithms to attain a faster convergence and a lower computational complexity. The proposed SEMBP algorithm adopts the uniform method (which evenly scatters solution agents over the feasible solution region and the species technique to improve the algorithm’s ability to find the global optimum. Finally, two illustrative examples of nonlinear systems control are presented to demonstrate the performance and the effectiveness of the proposed AIT2FNS with the SEMBP algorithm.

Allergen immunotherapy in allergic rhinitis: current use and future trends.

Science.gov (United States)

Klimek, Ludger; Pfaar, Oliver; Bousquet, Jean; Senti, Gabriela; Kündig, Thomas

2017-09-01

Type-1 allergies are among the most chronic common diseases of humans. Allergen immunotherapy (AIT) is the only causative and disease-modifying treatment option besides allergen avoidance. Severe systemic adverse allergic reactions may be induced by every AIT treatment. Different approaches have been used to provide safer AIT preparations to lower or even totally overcome this risk. Areas covered: A structured literature recherche in Medline and Pubmed under inclusion of national and international guidelines and Cochrane meta-analyses has been performed aiming at reviewing clinical use of such approaches in AIT. New allergen preparations may include allergoids, recombinant allergens (recA) and modified recombinant allergens (recA) in subcutaneous as well as in mucosal immunotherapies (application e.g. using bronchial, nasal, oral and sublingual application) with sublingual being the established mucosal application route and new ways of application like intralymphatic and epicutaneous immunotherapy. Expert commentary: Immune-modifying agents like Virus-like particles and CpG-motifs, adjuvants like MPL and aluminum hydroxide are evaluated and found to increase and direct the immunological response toward immunological tolerance. New forms of allergen extracts can improve safety and efficacy of AIT and may change our way of performing allergen immunotherapy in the future.

Modified Allergens for Immunotherapy.

Science.gov (United States)

Satitsuksanoa, Pattraporn; Głobińska, Anna; Jansen, Kirstin; van de Veen, Willem; Akdis, Mübeccel

2018-02-16

During the past few decades, modified allergens have been developed for use in allergen-specific immunotherapy (AIT) with the aim to improve efficacy and reduce adverse effects. This review aims to provide an overview of the different types of modified allergens, their mechanism of action and their potential for improving AIT. In-depth research in the field of allergen modifications as well as the advance of recombinant DNA technology have paved the way for improved diagnosis and research on human allergic diseases. A wide range of structurally modified allergens has been generated including allergen peptides, chemically altered allergoids, adjuvant-coupled allergens, and nanoparticle-based allergy vaccines. These modified allergens show promise for the development of AIT regimens with improved safety and long-term efficacy. Certain modifications ensure reduced IgE reactivity and retained T cell reactivity, which facilities induction of immune tolerance to the allergen. To date, multiple clinical trials have been performed using modified allergens. Promising results were obtained for the modified cat, grass and birch pollen, and house dust mite allergens. The use of modified allergens holds promise for improving AIT efficacy and safety. There is however a need for larger clinical studies to reliably assess the added benefit for the patient of using modified allergens for AIT.

Optimization of the Extraction of Anthocyanins from the Fruit Skin of Rhodomyrtus tomentosa (Ait. Hassk and Identification of Anthocyanins in the Extract Using High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry (HPLC-ESI-MS

Directory of Open Access Journals (Sweden)

Yuan-Ming Sun

2012-05-01

Full Text Available Anthocyanins are naturally occurring polyphenols that impart bright color to fruits, vegetables and plants. In this study, the extraction of anthocyanins from freeze-dried fruit skin of downy rose-myrtle (Rhodomyrtus tomentosa (Ait. Hassk var. Gangren was optimized using response surface methodology (RSM. Using 60% ethanol containing 0.1% (v/v hydrochloric acid as extraction solvent, the optimal conditions for maximum yields of anthocyanin (4.358 ± 0.045 mg/g were 15.7:1 (v/w liquid to solid ratio, 64.38 °C with a 116.88 min extraction time. The results showed good fits with the proposed model for the anthocyanin extraction (R² = 0.9944. Furthermore, the results of high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS analysis of the anthocyanins extracted from the fruit skin of downy rose-myrtle revealed the presence of five anthocyanin components, which were tentatively identified as delphinidin-3-glucoside, cyanidin-3-glucoside, peonidin-3-glucoside, petunidin-3-glucoside and malvidin-3-glucoside.

Health economic analysis of allergen immunotherapy for the management of allergic rhinitis, asthma, food allergy and venom allergy: A systematic overview.

Science.gov (United States)

Asaria, M; Dhami, S; van Ree, R; Gerth van Wijk, R; Muraro, A; Roberts, G; Sheikh, A

2018-02-01

The European Academy of Allergy and Clinical Immunology (EAACI) is developing guidelines for allergen immunotherapy (AIT) for the management of allergic rhinitis, allergic asthma, IgE-mediated food allergy and venom allergy. To inform the development of clinical recommendations, we undertook systematic reviews to critically assess evidence on the effectiveness, safety and cost-effectiveness of AIT for these conditions. This study focusses on synthesizing data and gaps in the evidence on the cost-effectiveness of AIT for these conditions. We produced summaries of evidence in each domain, and then, synthesized findings on health economic data identified from four recent systematic reviews on allergic rhinitis, asthma, food allergy and venom allergy, respectively. The quality of these studies was independently assessed using the Critical Appraisal Skills Programme tool for health economic evaluations. Twenty-three studies satisfied our inclusion criteria. Of these, 19 studies investigated the cost-effectiveness of AIT in allergic rhinitis, of which seven were based on data from randomized controlled trials with economic evaluations conducted from a health system perspective. This body of evidence suggested that sublingual immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT) would be considered cost-effective using the (English) National Institute for Health and Clinical Excellence (NICE) cost-effectiveness threshold of £20 000/quality-adjusted life year (QALY). However, the quality of the studies and the general lack of attention to characterizing uncertainty and handling missing data should be taken into account when interpreting these results. For asthma, there were three eligible studies, all of which had significant methodological limitations; these suggested that SLIT, when used in patients with both asthma and allergic rhinitis, may be cost-effective with an incremental cost-effectiveness ratio (ICER) of £10 726 per QALY. We found one economic modelling

African Journal of Biotechnology - Vol 9, No 1 (2010)

African Journals Online (AJOL)

Effect of Ramadan fasting on glucose, glycosylated haemoglobin, insulin, lipids and proteinous concentrations in women with non-insulin dependent diabetes mellitus · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. D Ait Saada, G Selselet, L Belkacemi, O Ait ...

Hypoallergenic molecules for subcutaneous immunotherapy

NARCIS (Netherlands)

Jongejan, Laurian; van Ree, Ronald; Poulsen, Lars K.

2016-01-01

Although a large part of the population suffers from allergies, a cure is not yet available. Allergen-specific immunotherapy (AIT) offers promise for these patients. AIT has proven successful in insect and venom allergies; however, for food allergy this is still unclear. In this editorial we focus

Allergen immunotherapy for IgE-mediated food allergy

DEFF Research Database (Denmark)

Dhami, Sangeeta; Nurmatov, Ulugbek; Pajno, Giovanni Battista

2016-01-01

BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food...

Month of birth is associated with the subsequent diagnosis of autoimmune hypothyroidism

DEFF Research Database (Denmark)

Thvilum, Marianne; Hjelm Brandt Kristensen, Frans; Brix, Thomas Heiberg

2017-01-01

the development of autoimmune hypothyroidism (AIT) is influenced by month or season of birth is less clear. METHOD: Nationwide cohort study of 111,565 individuals diagnosed with AIT and four euthyroid controls per case, matched according to age and sex, were identified from Danish health registers. Differences...

Case report

African Journals Online (AJOL)

ebutamanya

17 janv. 2016 ... Budd-Chiari syndrome: a rare complication of hepatic sarcoidosis (about one case). Ismael Ait Sghier1,&, Nabil Moatassim Billah1. 1Service de Radiologie Centrale, Hôpital Avicenne, Rabat, Maroc. &Corresponding author: Ismael Ait Sghier, Service de Radiologie Centrale, Hôpital Avicenne, Rabat, Maroc.

Attention Effects on Neural Population Representations for Shape and Location Are Stronger in the Ventral than Dorsal Stream

Science.gov (United States)

2018-01-01

Abstract We examined how attention causes neural population representations of shape and location to change in ventral stream (AIT) and dorsal stream (LIP). Monkeys performed two identical delayed-match-to-sample (DMTS) tasks, attending either to shape or location. In AIT, shapes were more discriminable when directing attention to shape rather than location, measured by an increase in mean distance between population response vectors. In LIP, attending to location rather than shape did not increase the discriminability of different stimulus locations. Even when factoring out the change in mean vector response distance, multidimensional scaling (MDS) still showed a significant task difference in AIT, but not LIP, indicating that beyond increasing discriminability, attention also causes a nonlinear warping of representation space in AIT. Despite single-cell attentional modulations in both areas, our data show that attentional modulations of population representations are weaker in LIP, likely due to a need to maintain veridical representations for visuomotor control. PMID:29876521

Amiodarone-Induced Thyrotoxic Thyroiditis: A Diagnostic and Therapeutic Challenge

Directory of Open Access Journals (Sweden)

Umang Barvalia

2014-01-01

Full Text Available Amiodarone is an iodine-based, potent antiarrhythmic drug bearing a structural resemblance to thyroxine (T4. It is known to produce thyroid abnormalities ranging from abnormal thyroid function testing to overt hypothyroidism or hyperthyroidism. These adverse effects may occur in patients with or without preexisting thyroid disease. Amiodarone-induced thyrotoxicosis (AIT is a clinically recognized condition commonly due to iodine-induced excessive synthesis of thyroid, also known as type 1 AIT. In rare instances, AIT is caused by amiodarone-induced inflammation of thyroid tissue, resulting in release of preformed thyroid hormones and a hyperthyroid state, known as type 2 AIT. Distinguishing between the two states is important, as both conditions have different treatment implications; however, a mixed presentation is not uncommon, posing diagnostic and treatment challenges. We describe a case of a patient with amiodarone-induced type 2 hyperthyroidism and review the current literature on the best practices for diagnostic and treatment approaches.

Association Between Thyroid Hormones, Thyroid Antibodies, and Cardiometabolic Factors in Non-Obese Individuals With Normal Thyroid Function

Directory of Open Access Journals (Sweden)

Jia Liu

2018-04-01

Full Text Available BackgroundHypothyroidism is an important risk factor for cardiovascular diseases, and autoimmune thyroiditis (AIT is the leading cause of hypothyroidism. Recent studies showed that even AIT patients with euthyroidism still had an increased number of early atherosclerotic lesions. However, the precise mechanism is not yet known. This study aimed to investigate the association of thyroid function, thyroid autoimmunity, and cardiometabolic risk factors in non-obese AIT patients with euthyroidism.MethodsA total of 5,608 non-obese individuals including 1,402 AIT patient and 4,206 sex-, age-, and body mass index (BMI-matched healthy controls were recruited.ResultsThe AIT patients had significantly lower free T3 and free T4 levels, and higher TSH, antithyroid peroxidase antibodies (TPOAb and TgAb levels. The elevated levels of high sensitivity C reactive protein (hsCRP and homeostasis model assessment of insulin resistance (HOMA-IR were observed in the AIT patients than the controls [hsCRP: 0.65 (0.27–1.33 vs. 0.20 (0.03–0.74 mg/L; HOMA-IR: 2.78 ± 1.60 vs. 2.33 ± 1.49; all P < 0.05]. Thyroid function was not associated with metabolic parameters and inflammatory makers, while the TPOAb titer was positively associated with the HOMA-IR and hsCRP levels after adjustment for confounding factors (all P < 0.05. Multivariate regression analysis demonstrated that the TPOAb level was an independent influencing factor for the HOMA-IR and hsCRP levels (HOMA-IR: β = 0.058, P < 0.05; hsCRP: β = 0.108, P < 0.05.ConclusionThe TPOAb level is associated with HOMA-IR and hsCRP levels independently of thyroid function in non-obese individuals. Mild deviation of thyroid function within the normal range, chronic inflammation, and insulin resistance may be the links between AIT and atherosclerosis in the non-obese population.

An EAACI “European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI)”: the methodology

DEFF Research Database (Denmark)

Calderón, Moises A; Rodríguez Del Río, Pablo; Vidal, Carmen

2014-01-01

and a "harmonised terminology" according to MedDRA, we aimed to prospectively collect systemic adverse reactions due to AIT from real life clinical settings. Under the framework of the EAACI, a team of European specialists in AIT, pharmacovigilance, epidemiology and drugs regulation set up a web-based prospective...

Trading in Education: The "Agreement on Internal Trade," Labour Mobility and Teacher Certification in Canada

Science.gov (United States)

Henley, Dick; Young, Jon

2009-01-01

Canada's provincial and territorial governments are committed to implement the Labour Mobility chapter of the "Agreement on Internal Trade" (AIT) in 2009. This article examines the implications of this agreement for teacher certification and teacher education programs. It argues that the full impact of AIT will not be immediately…

Debates in allergy medicine: specific immunotherapy efficiency in children with atopic dermatitis

Directory of Open Access Journals (Sweden)

Tatiana A. Slavyanakaya

2016-04-01

Full Text Available Abstract Allergen specific immunotherapy (AIT has been the only pathogenetically relevant treatment of IgE-mediated allergic diseases (ADs for many years. The use of AIT for atopic dermatitis (AD treatment is dubious and has both followers and opponents. The improvement of subcutaneous AIT (SCIT and introduction of Sublingual immunotherapy (SLIT gives prospects of their application both for adults and children suffering from AD. This review presents results of scientific research, system and meta-analyses that confirm the clinical efficacy of AIT for children with AD who has the sensitization to allergens of house dust mite, grass and plant pollen suffering from co-occurring respiratory ADs and with moderate and severe course of allergic AD. There have been analyzed the most advanced achievements in AIT studies as well as there have been specified the unmet needs in AD. The preliminary diagnostics of IgE-mediated AD and pathophysiological disorders, including immune ones, will allow a doctor to develop appropriate comprehensive treatment algorithm for children’s AD aimed at its correction. The including of AIT to the children’s comprehensive therapy program is reasonable only if AD has the allergic form. It is necessary better to design the randomized research studies and to acquire extended clinical practice in children with AD. Use of the successes of molecular-based allergy diagnostics will help to optimize and personalize the process of selecting the necessary allergens to determine the most appropriate vaccines for children considering the results of the allergen component diagnostics. The strategy of treatment of children with AD in future will be based on individual target therapy.

Fire biblioteker - fire universiteter - ét forskningsregistreringssystem

DEFF Research Database (Denmark)

Kristensen, Thøger; Bang, Tove; Price, Adie

2005-01-01

Bibliotekerne ved Handelshøjskolen i Århus, Den kgl. Veterinær- og Landbohøjskole, Roskilde Universitet og Aalborg Universitet har valgt softwaresystemet PURE som platform for registrering og formidling af forskning og forskningspublikationer fra deres respektive universiteter....

Strategisk Varsling

DEFF Research Database (Denmark)

Printz, Louis; Olesen, Frank

1994-01-01

Erhvervslivets interesse og behov for værktøjer til anvendelse i strategisk varsling er stigende. I erkendelse af dette har Institut for Organisation og Ledelse ved Handelshøjskolen i Århus intensiveret forskningsindsatsen på området....

Quality in education

DEFF Research Database (Denmark)

Madsen, Ole Nørgaard; Carlsson, Ricci

1996-01-01

Artiklen beskriver en model for implementering af kvalitetsledelse på en uddannelsesinstitution. Modellen er udviklet i samarbejde med Århus Tekniske Skole. Den består af 7 faser: kulturdiagnose, kulturrevision, orientering, kvalitetsorganisering, kvalitetsplanlægning, træning af kvalitetsevaluer...

Índice de dispersión poblacional distrital (IDP para la estimación de necesidades de recursos humanos en salud del primer nivel de atención

Directory of Open Access Journals (Sweden)

Carmela Álvarez

2015-01-01

Full Text Available Introducción: El Ministerio de Salud de Perú (MINSA viene implementando políticas y estrategias orientadas a garantizar el acceso a atención con equidad, oportunidad y calidad; para lo cual se requiere contar con recursos humanos (RHUS suficientes y adecuadamente distribuidos en los diferentes niveles de atención. Así, es fundamental estimar la brecha de RHUS especialmente en el primer nivel de atención, incorporando en particular como criterio, la dispersión poblacional presente en el país. Objetivos: Diseñar, validar y aplicar un índice de dispersión poblacional distrital (IDP que caracterice la dispersión distrital y aporte en la estimación de brecha de RHUS en el primer nivel de atención. Diseño: Estudio observacional y analítico, análisis multivariado. Lugar: Dirección General de Gestión del Desarrollo de Recursos Humanos MINSA, Perú. Participantes: Se consideró como unidad de análisis la totalidad de los distritos del Perú. Intervenciones: Análisis factorial exploratorio que considera variables demográficas, sociales, económicas y de acceso a los servicios de salud, obtenidas de los Censos de Población y Vivienda (2005 y 2007 y la Encuesta Nacional Continua (2006. Principales medidas de resultado: Índice de dispersión poblacional distrital. Resultados: El IDP fue estructurado y validado con la relación oficial de municipios rurales y la percepción de los operadores sanitarios de los Gobiernos Regionales del país. De las 1 831 municipalidades evaluadas, se clasificó los 1 277 distritos considerados rurales de acuerdo a la clasificación de Presidencia de Consejo de Ministros (PCM como dispersos por la metodología; se identificó un 82% de concordancia. Conclusiones: El IDP diseñado y validado aporta en la estimación de brechas de RHUS para los servicios asistenciales del primer nivel de atención en el Perú.

(AIT) AGAINST ANOPHELES GAMBIAE

African Journals Online (AJOL)

USER

These extracts were tested for repellence against Anopheles gambiae using the human-bait technique ... Synthetic chemicals and insecticides used for control of vectors are causing ... basil, for use as topical repellents against both diurnal and nocturnal .... The physical properties of Euphorbia balsamifera. (Table 1) reveal ...

Effect of long-term exclusion of fire and herbivory on the soils and ...

African Journals Online (AJOL)

The wettest grassland, Piet Retief Sourveld on a southern aspect, was transformed to a shrubland matrix (mainly Helichrysum splendidum) with tree clumps of forest precursor species (Rhus dentata, Halleria lucida, Myrsine africana, Buddleja salviifolia, Leucosidea ... Ferns benefitted from exclusion of fire and herbivory.

13C-isotopic fingerprint of Pinus pinaster Ait. and Pinus sylvestris L. wood related to the quality of standing tree mass in forests from NW Spain.

Science.gov (United States)

Fernandez, Irene; González-Prieto, Serafin J; Cabaneiro, Ana

2005-01-01

Pine forest plantations of Pinus pinaster Ait. and P. sylvestris L. located in Galicia, NW Spain, were selected to study the 13C/12C-isotopic fingerprint in wood core samples in order to find possible relationships between the delta(13)C at natural abundance levels and the quality of the standing tree mass. For each pine species, 24 forests growing on acidic soils were studied: half developed over granite and half over schists. Two dominant trees from each plot, corresponding to all possible combinations of forest stands with high or low site index and with adults or young trees, were drilled at the basal part of trunks using a Pressler drill to obtain tree ring samples. The C-isotopic compositions of the litter and the soil organic matter from different soil depths were also determined and statistically significant correlations between these values and the 13C content of the wood were observed. Despite internal variations due to the influence of site index, tree age and parent material, the isotopic fingerprint of P. pinaster wood (mean value delta13C=-26.2+/-0.8 per thousand) significantly differed (Ppinaster stands (r=-0.667, Ppinaster growing over schists (r=-0.833, Ppinaster trees is higher when plots over granite or schists are separately considered. A similar fact occurs for adult P. sylvestris trees from schists stands, high quality specimens being 13C-depleted compared with low quality ones. On the other hand, 13C natural abundance of wood from P. sylvestris trees seems to be also strongly influenced by the underlying parent material, young trees from granite stands having a statistically higher 13C-isotopic composition (P<0.05) than young trees from schists stands. Copyright (c) 2005 John Wiley & Sons, Ltd.

Family intervention for children with functional somatic symptoms

DEFF Research Database (Denmark)

Hulgaard, Ditte Roth; Dehlholm-Lambertsen, Birgitte; Rask, Charlotte Ulrikka

lidelser, Århus; Århus universitet Aim & Background: Functional somatic symptoms (FSS) can be defined as physical symptoms that cannot be fully explained by organic pathology. FSS are prevalent in children worldwide and in all medical settings, and when severe, pose a major burden on those with FSS...... and on society. In clinical practice and current research in child mental health, focus on family factors is increasing. The aim of this systematic review was to explore and describe the current family based approaches used for youngsters with FSS, and to evaluate the quality of the existing research...... quality scores on the POMRF. Many different outcome measures were employed, and the outcome measures chosen did not necessarily reflect what was targeted in the therapy. Focus on illness beliefs and shifting focus away from an organic explanation was agreed upon in all studies, with the alternative...

Improving the performance of the actinic inspection tool with an optimized alignment procedure

International Nuclear Information System (INIS)

Mochi, I.; Goldberg, K.A.; Naulleau, P.; Huh, Sungmin

2009-01-01

Extreme ultraviolet (EUV) microscopy is an important tool for the investigation of the performance of EUV masks, for detecting the presence and the characteristics of defects, and for evaluating the effectiveness of defect repair techniques. Aerial image measurement bypasses the difficulties inherent to photoresist imaging and enables high data collection speed and flexibility. It provides reliable and quick feedback for the development of masks and lithography system modeling methods. We operate the SEMATECH Berkeley Actinic Inspection Tool (AIT), a EUV microscope installed at the Advanced Light Source at Lawrence Berkeley National Laboratory. The AIT is equipped with several high-magnification Fresnel zoneplate lenses, with various numerical aperture values, that enable it image the reflective mask surface with various resolution and magnification settings. Although the AIT has undergone significant recent improvements in terms of imaging resolution and illumination uniformity, there is still room for improvement. In the AIT, an off-axis zoneplate lens collects the light coming from the sample and an image of the sample is projected onto an EUV-sensitive CCD camera. The simplicity of the optical system is particularly helpful considering that the AIT alignment has to be performed every time that a sample or a zoneplate is replaced. The alignment is sensitive to several parameters such as the lens position and orientation, the illumination direction and the sample characteristics. Since the AIT works in high vacuum, there is no direct access to the optics or to the sample during the alignment and the measurements. For all these reasons the alignment procedures and feedback can be complex, and in some cases can reduce the overall data throughput of the system. In this paper we review the main strategies and procedures that have been developed for quick and reliable alignments, and we describe the performance improvements we have achieved, in terms of aberration

Improving the performance of the actinic inspection tool with an optimized alignment procedure

Energy Technology Data Exchange (ETDEWEB)

Mochi, I.; Goldberg, K.A.; Naulleau, P.; Huh, Sungmin

2009-03-04

Extreme ultraviolet (EUV) microscopy is an important tool for the investigation of the performance of EUV masks, for detecting the presence and the characteristics of defects, and for evaluating the effectiveness of defect repair techniques. Aerial image measurement bypasses the difficulties inherent to photoresist imaging and enables high data collection speed and flexibility. It provides reliable and quick feedback for the development of masks and lithography system modeling methods. We operate the SEMATECH Berkeley Actinic Inspection Tool (AIT), a EUV microscope installed at the Advanced Light Source at Lawrence Berkeley National Laboratory. The AIT is equipped with several high-magnification Fresnel zoneplate lenses, with various numerical aperture values, that enable it image the reflective mask surface with various resolution and magnification settings. Although the AIT has undergone significant recent improvements in terms of imaging resolution and illumination uniformity, there is still room for improvement. In the AIT, an off-axis zoneplate lens collects the light coming from the sample and an image of the sample is projected onto an EUV-sensitive CCD camera. The simplicity of the optical system is particularly helpful considering that the AIT alignment has to be performed every time that a sample or a zoneplate is replaced. The alignment is sensitive to several parameters such as the lens position and orientation, the illumination direction and the sample characteristics. Since the AIT works in high vacuum, there is no direct access to the optics or to the sample during the alignment and the measurements. For all these reasons the alignment procedures and feedback can be complex, and in some cases can reduce the overall data throughput of the system. In this paper we review the main strategies and procedures that have been developed for quick and reliable alignments, and we describe the performance improvements we have achieved, in terms of aberration

Study on isolation of chemical constituents from Sophora ...

African Journals Online (AJOL)

Background: Sophora flavescens Ait. is a traditional Chinese medicine with a long history in China. It is mainly used in the treatment of heat dysentery and similar ailments in the clinical. The objective of this paper was to isolate, purify and identify alkaloids from Sophora flavescens Ait. and to explore their inhibitory effects on ...

STAR Algorithm Integration Team - Facilitating operational algorithm development

Science.gov (United States)

Mikles, V. J.

2015-12-01

The NOAA/NESDIS Center for Satellite Research and Applications (STAR) provides technical support of the Joint Polar Satellite System (JPSS) algorithm development and integration tasks. Utilizing data from the S-NPP satellite, JPSS generates over thirty Environmental Data Records (EDRs) and Intermediate Products (IPs) spanning atmospheric, ocean, cryosphere, and land weather disciplines. The Algorithm Integration Team (AIT) brings technical expertise and support to product algorithms, specifically in testing and validating science algorithms in a pre-operational environment. The AIT verifies that new and updated algorithms function in the development environment, enforces established software development standards, and ensures that delivered packages are functional and complete. AIT facilitates the development of new JPSS-1 algorithms by implementing a review approach based on the Enterprise Product Lifecycle (EPL) process. Building on relationships established during the S-NPP algorithm development process and coordinating directly with science algorithm developers, the AIT has implemented structured reviews with self-contained document suites. The process has supported algorithm improvements for products such as ozone, active fire, vegetation index, and temperature and moisture profiles.

Allergen immunotherapy for insect venom allergy: protocol for a systematic review.

Science.gov (United States)

Dhami, Sangeeta; Nurmatov, Ulugbek; Varga, Eva-Maria; Sturm, Gunter; Muraro, Antonella; Akdis, Cezmi A; Antolín-Amérigo, Darío; Bilò, M Beatrice; Bokanovic, Danijela; Calderon, Moises A; Cichocka-Jarosz, Ewa; Elberink, Joanna N G Oude; Gawlik, Radoslaw; Jakob, Thilo; Kosnik, Mitja; Lange, Joanna; Mingomataj, Ervin; Mitsias, Dimitris I; Mosbech, Holger; Pfaar, Oliver; Pitsios, Constantinos; Pravettoni, Valerio; Roberts, Graham; Ruëff, Franziska; Sin, Betül Ayşe; Sheikh, Aziz

2015-01-01

The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Insect Venom Allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in the management of insect venom allergy. We will undertake a systematic review, which will involve searching international biomedical databases for published, in progress and unpublished evidence. Studies will be independently screened against pre-defined eligibility criteria and critically appraised using established instruments. Data will be descriptively and, if possible and appropriate, quantitatively synthesised. The findings from this review will be used to inform the development of recomendations for EAACI's Guidelines on AIT.

Stabilized Laccases as Heterogeneous Bioelectrocatalysts (Postprint)

Science.gov (United States)

2012-10-01

Reference Rhus vernificera catechin (anticancer flavonoid ) • covalent binding (amide chemistry) to Au Nps in dendrimers [82] Rigidoporus lignosis phenolic...proper· tiesP· 391 An interesting extension to the application of laccases in biosensors is the medically relevant detection of catechins and flavonoids

Final Environmental Assessment: For a One-Megawatt Solar Array at Cheyenne Mountain Air Force Station

Science.gov (United States)

2010-04-01

approximately 122 26 acres (49 hectares), or 25 percent of the undeveloped land at CMAFS. The predominant species is 27 Gambel oak ( Quercus gambelii...tridentata), 29 skunkbush (Rhus americana), Arizona fescue (Festuca arizonica ), and blue grama (Bouteloua gracilis). 30 In the wetter locations, such

Reduced work/academic performance and quality of life in patients with allergic rhinitis and impact of allergen immunotherapy.

Science.gov (United States)

Roger, A; Arcalá Campillo, E; Torres, M C; Millan, C; Jáuregui, I; Mohedano, E; Liñan, S; Verdu, P; Rubira, N; Santaolalla, M; González, P; Orovitg, A; Villarrubia, E

2016-01-01

Allergic rhinitis (AR) is characterised by burdensome nasal and/or ocular symptoms. This inflammatory disease can be debilitating and thus result in considerable health-related and economic consequences. In a cross-sectional study, adult subjects with AR (N = 683) completed three allergy-specific questionnaires that assessed the impact of AR on the work/academic performance, daily activities, health-related quality of life (HRQOL), and satisfaction with allergen immunotherapy (AIT). Regression analyses were used to examine the associations between several clinical variables and the patient-reported outcomes. Total loss of productivity was 21.0 and 21.2 % for employed and student patients, respectively, whereas the impairment of daily activities was 22.0 %. The mean overall HRQOL score was 1.94 ± 1.29 (on the scale of 0-6 points). Global score for satisfaction with AIT was 65.5 ± 24.8 (on a 0-100 scale). Simple regression analysis found statistically significant associations between loss of work and academic productivity, impairment of daily activities and the type and severity of AR. AIT was a protective factor. The persistent and more severe types of AR and lack of AIT contributed to the worsening of HRQOL. AR (the persistent and more severe form of the disease) has an impact on functional characteristics of adult patients in Spain. AIT might reduce the effect of this disease on the work/academic performance and HRQOL. Trial registration Retrospectively registered.

Characteristics of eye-position gain field populations determine geometry of visual space

Directory of Open Access Journals (Sweden)

Sidney R Lehky

2016-01-01

Full Text Available We have previously demonstrated differences in eye-position spatial maps for anterior inferotemporal cortex (AIT in the ventral stream and lateral intraparietal cortex (LIP in the dorsal stream, based on population decoding of gaze angle modulations of neural visual responses (i.e., eye-position gain fields. Here we explore the basis of such spatial encoding differences through modeling of gain field characteristics. We created a population of model neurons, each having a different eye-position gain field. This population was used to reconstruct eye-position visual space using multidimensional scaling. As gain field shapes have never been well established experimentally, we examined different functions, including planar, sigmoidal, elliptical, hyperbolic, and mixtures of those functions. All functions successfully recovered positions, indicating weak constraints on allowable gain field shapes. We then used a genetic algorithm to modify the characteristics of model gain field populations until the recovered spatial maps closely matched those derived from monkey neurophysiological data in AIT and LIP. The primary differences found between model AIT and LIP gain fields were that AIT gain fields were more foveally dominated. That is, gain fields in AIT operated on smaller spatial scales and smaller dispersions than in LIP. Thus we show that the geometry of eye-position visual space depends on the population characteristics of gain fields, and that differences in gain field characteristics for different cortical areas may underlie differences in the representation of space.

Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis.

Science.gov (United States)

Nurmatov, U; Dhami, S; Arasi, S; Pajno, G B; Fernandez-Rivas, M; Muraro, A; Roberts, G; Akdis, C; Alvaro-Lozano, M; Beyer, K; Bindslev-Jensen, C; Burks, W; du Toit, G; Ebisawa, M; Eigenmann, P; Knol, E; Makela, M; Nadeau, K C; O'Mahony, L; Papadopoulos, N; Poulsen, L K; Sackesen, C; Sampson, H; Santos, A F; van Ree, R; Timmermans, F; Sheikh, A

2017-08-01

The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated Food Allergy. To inform the development of clinical recommendations, we sought to critically assess evidence on the effectiveness, safety and cost-effectiveness of AIT in the management of food allergy. We undertook a systematic review and meta-analysis that involved searching nine international electronic databases for randomized controlled trials (RCTs) and nonrandomized studies (NRS). Eligible studies were independently assessed by two reviewers against predefined eligibility criteria. The quality of studies was assessed using the Cochrane Risk of Bias tool for RCTs and the Cochrane ACROBAT-NRS tool for quasi-RCTs. Random-effects meta-analyses were undertaken, with planned subgroup and sensitivity analyses. We identified 1814 potentially relevant papers from which we selected 31 eligible studies, comprising of 25 RCTs and six NRS, studying a total of 1259 patients. Twenty-five trials evaluated oral immunotherapy (OIT), five studies investigated sublingual immunotherapy, and one study evaluated epicutaneous immunotherapy. The majority of these studies were in children. Twenty-seven studies assessed desensitization, and eight studies investigated sustained unresponsiveness postdiscontinuation of AIT. Meta-analyses demonstrated a substantial benefit in terms of desensitization (risk ratio (RR) = 0.16, 95% CI 0.10, 0.26) and suggested, but did not confirm sustained unresponsiveness (RR = 0.29, 95% CI 0.08, 1.13). Only one study reported on disease-specific quality of life (QoL), which reported no comparative results between OIT and control group. Meta-analyses revealed that the risk of experiencing a systemic adverse reaction was higher in those receiving AIT, with a more marked increase in the risk of local adverse reactions. Sensitivity analysis excluding those studies judged to be at high risk of bias demonstrated the

Individual concrete panels

DEFF Research Database (Denmark)

2008-01-01

DVD én formidler en workshop omhandlende udvikling, optimering og produktion af individuelle betonelementer. Workshoppen fandt sted 8. til 13. oktober 2007 i en af Peter Behren´s AEG turbinehaller i Berlin, hvor 10. arkitektstuderende fra Århus satte 10. inginiørstuderende fra tekniske universite...

The Spirit of the Place

DEFF Research Database (Denmark)

Dahlkild, Nan

2013-01-01

I artiklen undersøges udviklingen af skandinavisk biblioteksarkitektur og biblioteksindretning fra starten af det 20. århundrede frem til årtusindskiftet. Som karaktistiske hovedværker nævnes bl.a. biblioteket på Landsudstillingen Århus fra 1909, Det Deichmanske Bibliotek i Oslo, Stadsbiblioteket...

Educated Cities and Regional Centralization

DEFF Research Database (Denmark)

Eriksen, Jesper

centralization where the shares of students rose significantly more in urban municipalities than non-urban municipalities. The highest shares of students as well as fastest increases were seen in the municipalities of the four largest cities, Copenhagen, Århus, Odense, and Aalborg. At the national level...

Reductant-dependent electron distribution among redox sites of laccase

DEFF Research Database (Denmark)

Farver, O; Goldberg, M; Wherland, S

1978-01-01

Rhus laccase (monophenol monooxygenase, monophenol,dihydroxyphenylalanine:oxygen oxidoreductase, EC 1.14.18.1) an O2/H2O oxidoreductase containing four copper ions bound to three redox sites (type 1, type 2, and type 3 Cu pair), was titrated anaerobically with several reductants having various ch...

Industry and the environment-practical applications of environmental management approaches in business proceedings of the 3rd conference of the Nordic Business Environmental Management Network, March 28-30, 1996, Aarhus, Denmark

DEFF Research Database (Denmark)

Ulhøi, John Parm; Madsen, Henning

1996-01-01

Bogen indeholder refereed papers fra en international miljøledelseskonference ved Scandinavian Center Århus, arrangeret af forfatterne. Konferencen havde delegerede fra ialt 17 lande. Bogen, der indledes med en indledning skrevet af redaktørerne, er inddelt i en række hovedafsnit, der behandler e...

1909 - et vigtigt år i dansk bibliotekshistorie

DEFF Research Database (Denmark)

Dahlkild, Nan

2009-01-01

En undersøgelse af betydningen for dansk bibliotekshistorie af mønsterbiblioteket og forsamlingsbygningen på Landsudstillingen i Århus i 1909. 1:1 udstillingsbiblioteket og den efterfølgende indretning af biblioteket i Vejen markerede biblioteksbevægelsens og dermed biblioteksbyggeriets og biblio...

Terahertz gas sensor based on absorption-induced transparency

Directory of Open Access Journals (Sweden)

Rodrigo Sergio G.

2016-01-01

Full Text Available A system for the detection of spectral signatures of gases at the Terahertz regime is presented. The system consists in an initially opaque holey metal film whereby the introduction of a gas provokes the appearance of spectral features in transmission and reflection, due to the phenomenom of absorption-induced transparency (AIT. The peaks in transmission and dips in reflection observed in AIT occur close to the absorption energies of the molecules, hence its name. The presence of the gas would be thus revealed as a strong drop in reflectivity measurements at one (or several of the gas absorption resonances. As a proof of principle, we theoretically demonstrate how the AIT-based sensor would serve to detect tiny amounts of hydrocyanic acid.

Secondary metabolite profiling of Curcuma species grown at different locations using GC/TOF and UPLC/Q-TOF MS.

Science.gov (United States)

Lee, Jueun; Jung, Youngae; Shin, Jeoung-Hwa; Kim, Ho Kyoung; Moon, Byeong Cheol; Ryu, Do Hyun; Hwang, Geum-Sook

2014-07-04

Curcuma, a genus of rhizomatous herbaceous species, has been used as a spice, traditional medicine, and natural dye. In this study, the metabolite profile of Curcuma extracts was determined using gas chromatography-time of flight mass spectrometry (GC/TOF MS) and ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) to characterize differences between Curcuma aromatica and Curcuma longa grown on the Jeju-do or Jin-do islands, South Korea. Previous studies have performed primary metabolite profiling of Curcuma species grown in different regions using NMR-based metabolomics. This study focused on profiling of secondary metabolites from the hexane extract of Curcuma species. Principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA) plots showed significant differences between the C. aromatica and C. longa metabolite profiles, whereas geographical location had little effect. A t-test was performed to identify statistically significant metabolites, such as terpenoids. Additionally, targeted profiling using UPLC/Q-TOF MS showed that the concentration of curcuminoids differed depending on the plant origin. Based on these results, a combination of GC- and LC-MS allowed us to analyze curcuminoids and terpenoids, the typical bioactive compounds of Curcuma, which can be used to discriminate Curcuma samples according to species or geographical origin.

Secondary Metabolite Profiling of Curcuma Species Grown at Different Locations Using GC/TOF and UPLC/Q-TOF MS

Directory of Open Access Journals (Sweden)

Jueun Lee

2014-07-01

Full Text Available Curcuma, a genus of rhizomatous herbaceous species, has been used as a spice, traditional medicine, and natural dye. In this study, the metabolite profile of Curcuma extracts was determined using gas chromatography-time of flight mass spectrometry (GC/TOF MS and ultrahigh-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS to characterize differences between Curcuma aromatica and Curcuma longa grown on the Jeju-do or Jin-do islands, South Korea. Previous studies have performed primary metabolite profiling of Curcuma species grown in different regions using NMR-based metabolomics. This study focused on profiling of secondary metabolites from the hexane extract of Curcuma species. Principal component analysis (PCA and partial least-squares discriminant analysis (PLS-DA plots showed significant differences between the C. aromatica and C. longa metabolite profiles, whereas geographical location had little effect. A t-test was performed to identify statistically significant metabolites, such as terpenoids. Additionally, targeted profiling using UPLC/Q-TOF MS showed that the concentration of curcuminoids differed depending on the plant origin. Based on these results, a combination of GC- and LC-MS allowed us to analyze curcuminoids and terpenoids, the typical bioactive compounds of Curcuma, which can be used to discriminate Curcuma samples according to species or geographical origin.

Online lektiehjælp

DEFF Research Database (Denmark)

Hansen, Jens Jørgen; Remvig, Kirstin

2016-01-01

vejledningsdidaktik, herunder metoder, modeller og materialer for lektievejledning i regi af Lektier Online. Lektier Online er en organisation ved Statsbiblioteket i Århus, der tilbyder en online lektiecafe, hvor bl.a. gymnasie-elever kan få hjælp af frivillige universitetsstuderende. Dette didaktiske de-sign er et...

Virksomhedens Miljøøkonomi. Hvad, hvorfor og hvordan

DEFF Research Database (Denmark)

Rikhardsson, Pall M.; Vedsø, Lars

Rapporten giver et overblik over resultaterne fra projektet Virksomhedens Miljøøkonomi: Afklaring, anvendelse og implementering. Projektet er udført af PricewaterhouseCoopers i samarbejde med Handelshøjskolen i Århus og med finansiel støtte fra ordningen Miljøstyring og -revision i danske...

IT-implementering som læreproces

DEFF Research Database (Denmark)

Wentzer, Helle; Bygholm, Ann

Rapporten er en evaluering af læreplanen for IT-implementering af en elektronisk journal i plejesektoren. Den indeholder en introduktion til Århus Kommunes Hjemmepleje, et teoriafsnit til organisation og læring, et afsnit til metode, et afsnit med selve analysen og endelige et afsnit med resultat...

Danskernes racisme

DEFF Research Database (Denmark)

Necef, Mehmet Ümit

2010-01-01

Jens Peter Frølund Thomsen, politolog fra Århus Universitet, har i bogen Konflikten om de nye danskere (2006) undersøgt danskernes holdninger til her-boende etniske minoriteter, herunder racismens omfang og dens former. Ar-tiklen diskuterer Thomsens definition på racisme og hans behandling af sin...

A statistical mechanical interpretation of algorithmic information theory: Total statistical mechanical interpretation based on physical argument

International Nuclear Information System (INIS)

Tadaki, Kohtaro

2010-01-01

The statistical mechanical interpretation of algorithmic information theory (AIT, for short) was introduced and developed by our former works [K. Tadaki, Local Proceedings of CiE 2008, pp. 425-434, 2008] and [K. Tadaki, Proceedings of LFCS'09, Springer's LNCS, vol. 5407, pp. 422-440, 2009], where we introduced the notion of thermodynamic quantities, such as partition function Z(T), free energy F(T), energy E(T), statistical mechanical entropy S(T), and specific heat C(T), into AIT. We then discovered that, in the interpretation, the temperature T equals to the partial randomness of the values of all these thermodynamic quantities, where the notion of partial randomness is a stronger representation of the compression rate by means of program-size complexity. Furthermore, we showed that this situation holds for the temperature T itself, which is one of the most typical thermodynamic quantities. Namely, we showed that, for each of the thermodynamic quantities Z(T), F(T), E(T), and S(T) above, the computability of its value at temperature T gives a sufficient condition for T is an element of (0,1) to satisfy the condition that the partial randomness of T equals to T. In this paper, based on a physical argument on the same level of mathematical strictness as normal statistical mechanics in physics, we develop a total statistical mechanical interpretation of AIT which actualizes a perfect correspondence to normal statistical mechanics. We do this by identifying a microcanonical ensemble in the framework of AIT. As a result, we clarify the statistical mechanical meaning of the thermodynamic quantities of AIT.

Advances and highlights in allergen immunotherapy: On the way to sustained clinical and immunologic tolerance.

Science.gov (United States)

Berings, Margot; Karaaslan, Cagatay; Altunbulakli, Can; Gevaert, Philippe; Akdis, Mübeccel; Bachert, Claus; Akdis, Cezmi A

2017-11-01

Allergen immunotherapy (AIT) is an effective treatment strategy for allergic diseases and has been used for more than 100 years. In recent years, however, the expectations on concepts, conduct, statistical evaluation, and reporting have developed significantly. Products have undergone dose-response and confirmative studies in adults and children to provide evidence for the optimal dosage, safety, and efficacy of AIT vaccines using subcutaneous and sublingual delivery pathways in large patient cohorts, ensuring solid conclusions to be drawn from them for the advantage of patients and societies alike. Those standards should be followed today, and products answering to them should be preferred over others lacking optimization and proof of efficacy and safety. Molecular and cellular mechanisms of AIT include early mast cell and basophil desensitization effects, regulation of T- and B-cell responses, regulation of IgE and IgG 4 production, and inhibition of responses from eosinophils, mast cells, and basophils in the affected tissues. There were many developments to improve vaccination strategies, demonstration of new molecules involved in molecular mechanisms, and demonstration of new biomarkers for AIT during the last few years. The combination of probiotics, vitamins, and biological agents with AIT is highlighting current advances. Development of allergoids and recombinant and hypoallergenic vaccines to skew the immune response from IgE to IgG 4 and regulation of dendritic cell, mast cell, basophil, innate lymphoid cell, T-cell, and B-cell responses to allergens are also discussed in detail. Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Current insights in allergen immunotherapy.

Science.gov (United States)

Passalacqua, Giovanni; Bagnasco, Diego; Ferrando, Matteo; Heffler, Enrico; Puggioni, Francesca; Canonica, Giorgio Walter

2018-02-01

Allergen-specific immunotherapy (AIT) in its subcutaneous and sublingual forms is currently a well-established and experimentally supported treatment for respiratory allergy and hymenoptera venom allergy. There have been advances in its use linked strictly to the advancement in the knowledge of the molecular mechanisms of allergy, the production of well-characterized extracts, and diagnostic techniques. The use of AIT in asthma and the application of new approaches are expanding. We briefly review the advances and concerns in the use of AIT. PubMed and Scopus. The most recent and clinically relevant literature was selected and reviewed. The introduction of high-quality products supported by large dose-finding trials has yielded better defined indications, contraindications, and modalities of use. Some specific products in tablet form have recently been approved in the United States. Sublingual immunotherapy has been found to be effective in asthma, which until recently had been a matter of debate. Another promising therapy is oral and sublingual desensitization for food allergy, for which encouraging results have recently been reported. In the near future, other options will be available, including new routes of administration (intralymphatic and epicutaneous), allergoids, engineered allergens, and peptides. The use of component-resolved diagnosis techniques will further refine and target AIT prescriptions. This condensed and updated review shows that AIT remains a viable treatment option, especially after the introduction of standardized tablets for some allergens. Food allergy and new administration routes represent a promising expansion. Copyright © 2017 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Lactobacillus ve Bifidobacterium Cinsi Bakterilerin Beta Galaktosidaz Enzim Aktivitelerinin Belirlenmesi

Directory of Open Access Journals (Sweden)

Yasemin Kılıç

2015-02-01

Full Text Available Bu çalışmada, insan, gıda ve hayvan kaynaklı 39 Lactobacilllus cinsine ait ve yeni doğan gaitasından izole edilmiş 3 Bifidobacterium cinsine ait toplam 42 bakteri kullanılmıştır. O-nitrofenil-beta-D-galaktosit (o-NPG substrat olarak kullanılarak, kültürlerin β-galaktosidaz enzim ve spesifik aktiviteleri belirlenmiştir. Lactobacillus cinsine ait kültürlerden L. fermentum ZYN17 (2.468 U/mg, L. casei LB65 (1.116 U/mg, L. rhamnosus GD11 (1.034 U/mg ve L. acidophilus BAZ36 (0.947 U/mg suşlarının, Bifidobacterium cinsine ait kültürlerden de B. breve A26 (0.726 U/mg suşunun en yüksek spesifik aktivite yeteneğine sahip oldukları tespit edilmiştir. Ayrıca, bakterilerin 5-brom-4-klor-3-indolil-β-D-galaktopiranosit (X-gal substrat bileşiğiyle de nitel olarak enzim aktivitesinin varlığı değerlendirilmiştir. Yüksek spesifik β-galaktozidaz aktivitesi gösteren ZYN17 suşuna ait β-galaktozidaz enziminin optimizasyonu yapılmıştır. β-galaktozidaz enziminin optimum pH’sı 6.8, optimum sıcaklığı 37 ºC ve optimum tamponun potasyum fosfat tamponu olduğu belirlenmiştir.

Effects of aerobic interval training versus continuous moderate exercise programme on aerobic and anaerobic capacity, somatic features and blood lipid profile in collegate females

Directory of Open Access Journals (Sweden)

Krzystof Mazurek

2014-11-01

Full Text Available introduction. Regular physical activity has many positive health benefits, including reducing the risk of cardiovascular diseases, metabolic diseases and some cancers, as well as improving the quality of life. objectives. The aim of the study was to examine the effects of 8-week aerobic interval cycle exercise training (AIT compared to continuous cycle exercises of moderate intensity (CME on the aerobic and anaerobic capacity, somatic features and lipid profile. material and methods. The research was conducted in 88 volunteers aged 19.5±0.6 years, who were randomized to three groups of organized physical activity (OPA, who exercised 3 times per week in 47 min sessions: (I AIT (n=24 comprising 2 series of 6x10 s sprinting with maximal pedalling cadence and active rest pedalling with intensity 65%–75% HRmax, (II CME (n=22 corresponding to 65%-75% HRmax, (III regular collegiate physical education classes of programmed exercises (CON; n=42. Before and after OPA anthropometrics, aero- and anaerobic capacity and lipid profile indices were measured. results. In AIT, a significantly greater decrease of waist circumference and WHR was noted when compared to CON, and a significantly greater reduction of sum of skinfolds than in CON and CME. Improvement in relative and absolute VO2max (L/min and ml/kg/min was significantly higher in AIT than CON. Work output and peak power output in the anaerobic test improved significantly in AIT, CME and CON, but independently of training type. OPA was effective only in reducing triglyceride concentrations in CME and CON groups, without interaction effects in relation to training type. conclusion. It was found that 8 weeks of OPA was beneficial in improving somatic and aerobic capacity indices, but AIT resulted in the greatest improvement in somatic indices (waist circumference, WHR, sum of skinfolds and in VO[sub]2[/sub]max, compared to CME and CON programmes.

Interval and continuous exercise regimens suppress neutrophil-derived microparticle formation and neutrophil-promoted thrombin generation under hypoxic stress.

Science.gov (United States)

Chen, Yi-Ching; Ho, Ching-Wen; Tsai, Hsing-Hua; Wang, Jong-Shyan

2015-04-01

Acute hypoxic exposure increases vascular thrombotic risk. The release of procoagulant-rich microparticles from neutrophils accelerates the pathogenesis of inflammatory thrombosis. The present study explicates the manner in which interval and continuous exercise regimens affect neutrophil-derived microparticle (NDMP) formation and neutrophil/NDMP-mediated thrombin generation (TG) under hypoxic condition. A total of 60 sedentary males were randomized to perform either aerobic interval training [AIT; 3-min intervals at 40% and 80% V̇O2max (maximal O2 consumption)] or moderate continuous training (MCT; sustained 60% V̇O2max) for 30 min/day, 5 days/week for 5 weeks, or to a control (CTL) group who did not receive any form of training. At rest and immediately after hypoxic exercise test (HE, 100 W under 12% O2 for 30 min), the NDMP characteristics and dynamic TG were measured by flow cytometry and thrombinography respectively. Before the intervention, HE (i) elevated coagulant factor VIII/fibrinogen concentrations and shortened activated partial thromboplastin time (aPTT), (ii) increased total and tissue factor (TF)-rich/phosphatidylserine (PS)-exposed NDMP counts and (iii) enhanced the peak height and rate of TG promoted by neutrophils/NDMPs. Following the 5-week intervention, AIT exhibited higher enhancement of V̇O2max than did MCT. Notably, both MCT and AIT attenuated the extents of HE-induced coagulant factor VIII/fibrinogen elevations and aPTT shortening. Furthermore, the two exercise regimens significantly decreased TF-rich/PS-exposed NDMP formation and depressed neutrophil/NDMP-mediated dynamic TG at rest and following HE. Hence, we conclude that AIT is superior to MCT for enhancing aerobic capacity. Moreover, either AIT or MCT effectively ameliorates neutrophil/NDMP-promoted TG by down-regulating expression of procoagulant factors during HE, which may reduce thrombotic risk evoked by hypoxia. Moreover, either AIT or MCT effectively ameliorates neutrophil

Uptake of health checks by residents from the Danish social housing sector – a register-based cross-sectional study of patient characteristics in the ‘Your Life – Your Health’ program

DEFF Research Database (Denmark)

Bruun Larsen, Lars

2018-01-01

Lav deltagelse blandt socioøkonomisk dårligt stillede er en velkendt udfordring for helbredstjek. I denne artikel rapporterer vi på resultaterne af en registerbaseret tværsnitsundersøgelse af patient karakteristika blandt 6650 beboere i almennyttige boligområder i Århus Kommune, som blev invitere...

Medarbejderdreven innovation i den offentlige sektor

DEFF Research Database (Denmark)

Klitmøller, Anders; Lauring, Jakob; Christensen, Poul Rind

2007-01-01

Denne artikel har til formål at kaste lys over den rolle, medarbejderne spiller for den innovative aktivitet i den offentlige sektor, hvad vi har valgt at kalde medarbejderdreven innovation. Artiklen er baseret på et etnografisk feltstudie i Århus Kommune, nærmere bestemt den nye afdeling...

Re-presenting Scandinavian Modernism

DEFF Research Database (Denmark)

Skou, Niels Peter

Med Gellerupparken ved Århus som eksempel undersøges den rolle æstetiske repræsentationer (visuelle og sproglige) har for betydningsdannelsen omkring arkitektur. I paperet trækkes en linje fra Le Corbusiers skrifter om æstetik og modernismens projekt om 'æstetisk opdragelse' af publikum til den...

Miljøledelse: Tanker, erfaringer og visioner. John Parm Ulhøi og Henning Madsen (red.)

DEFF Research Database (Denmark)

Ulhøi, John Parm; Madsen, Henning

Bogen indeholder udvalgte og bearbejdede bidrag fra en international konference, som blev afholdt i 1996 med Handelshøjskolen i Århus som arrangør. Bogen giver et overblik over centrale elementer i miljøledelse, og bringer de nyeste forskningsresultater inden for området - med udgangspunkt i prak...

Text condensation in consecutive interpreting - summary of a Ph.d.-dissertation

DEFF Research Database (Denmark)

Dam, Helle Vrønning

1996-01-01

Artiklen er et resumé af en Ph.d.-afhandling med titlen 'Tekstkondensering i foredragstolkning', som blev indleveret ved Det Erhvervssproglige Fakultet, Handelshøjskolen i Århus, i oktober 1995. I artiklen skitseres den valgte interdisciplinære tilgang til det fænomen, der undersøges i afhandling...

Screening for the P-glycoprotein inhibitory pump activity of plant ...

African Journals Online (AJOL)

The results revealed that out of the 45 plant extracts tested, 3 extracts i.e. Bauhinia thoningii, Clerodendrum myricoides and Rhus natalensis exhibited pronounced activity at the concentration of 100 µg/ml. In comparison to the negative control, B. thoningii, C. myricoides and R. natalensis extracts inhibited the pump by a ...

Analyse af vindforhold på Viborgvej/Bredskiftevej

DEFF Research Database (Denmark)

Rasmussen, Michael R.; Lauridsen, Thomas Bank; Kjemtrup, Inge-Mette

Formålet med denne undersøgelse er at afklare, hvorvidt opførelsen af højhuse ved krydset Viborgvej/Bredskiftevej i Århus V medfører uhensigtsmæssige eller farlige vindforhold for fodgængere og cyklister i området omkring de høje bygninger....

Increased presevation of sliced mozzarella cheese by antimibrobial sachet incorporated with allyl isothiocyanate

Directory of Open Access Journals (Sweden)

Ana Clarissa dos Santos Pires

2009-12-01

Full Text Available There is an increasing tendency to add natural antimicrobials of plant origin into food. The objective of this work was to develop a microbial sachet incorporated with allyl isothiocyanate (AIT, a volatile compound of plant origin, and to test its efficiency against growth of yeasts and molds, Staphylococcus sp. and psychrotrophic bacteria on sliced mozzarella cheese. Another objective was to quantify the concentration of AIT in the headspace of cheese packaging. A reduction of 3.6 log cycles was observed in yeasts and molds counts in the mozzarella packed with the antimicrobial sachet over 15-day storage time. The sachet also showed an antibacterial effect on Staphylococcus sp., reducing 2.4 log cycles after 12-day storage. Psychrotrophic bacteria species were the most resistant to the antimicrobial action. The highest concentration of AIT (0.08µg.mL-1 inside the active packaging system was observed at the 6-day of storage at 12 ºC ± 2 ºC. At the end of the storage time, AIT concentration decreased to only 10% of the initial concentration. Active packaging containing antimicrobial sachet has a potential use for sliced mozzarella, with molds and yeasts being the most sensitive to the antimicrobial effects.

Det europæiske Model Company Law Act Project

DEFF Research Database (Denmark)

Andersen, Paul Krüger; Baums, Theodor

2008-01-01

På initiativ af forfatterne til det følgende blev der i 2007 dannet en europæisk gruppe af fremtrædende selskabsretseksperter med henblik på at udforme en »European Model Company Law Act« (EMCLA). Gruppen holdt sit første møde i Århus i september 2007.  ...

Fucking mange tusser

DEFF Research Database (Denmark)

Olesen, Annette; Jensen, Sune Qvotrup

2009-01-01

Artiklen diskuterer resultaterne af et etnografisk feltarbejde blandt kriminaliserede unge mænd med etnisk minoritetsbaggrund i Århus. Forfatterne ønsker at at vise, at der mangler noget grundlæggende i forståelsen af visse kriminalitetsmønstre, der udvikles på kanten af samfundet, og som først o...

Entropy as a new measure of mechanical pain sensitivity in the masseter muscle

DEFF Research Database (Denmark)

Castrillon, Eduardo; Sato, Hitoshi; Tanosoto, Tomohiro

ENTROPY AS A NEW MEASURE OF MECHANICAL PAIN SENSITIVITY IN THE MASSETER MUSCLE Author Block: E. E. Castrillon1, H. Sato2,3, T. Tanosoto4, T. Arima4, L. Baad-Hansen1, P. Svensson1, 1Clinical Oral Physiology, Århus Univ., Aarhus, Denmark, 2Dept. of Dentistry & Oral Physiology, Sch. of Med., Keio Un...... injections (Pmechanical pain sensitivity that captures new aspects of spatial characteristics and could therefore complement more classical assessments of TMD pain patients.......ENTROPY AS A NEW MEASURE OF MECHANICAL PAIN SENSITIVITY IN THE MASSETER MUSCLE Author Block: E. E. Castrillon1, H. Sato2,3, T. Tanosoto4, T. Arima4, L. Baad-Hansen1, P. Svensson1, 1Clinical Oral Physiology, Århus Univ., Aarhus, Denmark, 2Dept. of Dentistry & Oral Physiology, Sch. of Med., Keio Univ......., Tokyo, Japan, 3Japan Society for the Promotion of Sci., Tokyo, Japan, 4Dept. of Oral Rehabilitation, Graduate Sch. of Dental Med., Hokkaido Univ., Sapporo, Japan : Aim of Investigation: Manual palpation is a psychophysical technique to evaluate mechanical pain sensitivity in craniofacial muscles...

PET i Århus: et laboratoriums tilblivelse

DEFF Research Database (Denmark)

Gjedde, Albert

2006-01-01

Recent medical history is a new trend among medical historians. The new focus on late developments of note to health care providers has inspired me to relate certain personal events related to the establishment of a laboratory of positron emission tomography in a remote city of a small country far......-directed inventions that include the discovery of positrons, the invention of the cyclotron, the development of computerized analysis of huge data sets, insight into the biochemistry of organs and the quest for understanding of the pathology of specific diseases. U.S. researchers played unique roles in the three...

Larvicidal activity of some Cerrado plant extracts against Aedes aegypti

OpenAIRE

Rodrigues, A.M.S.; De Paula, J.E.; Dégallier, Nicolas; Molez, Jean-François; Espindola, L.S.

2006-01-01

One hundred ninety hexanic and ethanolic extracts from 27 plant species from the Cerrado biome of Brazil were tested for larvicidal activity against 3rd-stage Aedes aegypti larvae at 500 mu g/ml. Fourteen extracts from 7 species showed activity (> 65% mortality) against the larvae. Of these, Duguetia furfuracea, Piptocarpha rotundifolia, Casearia sylvestris var. lingua, Serjania lethalis, and Xylopia aromatica were active at 56.6, 162.31, 232.4, 285.76, and 384.37 mu g/ml, respectively. Annon...

Lorsque la croissance ne suffit pas : en quête d'une économie ...

International Development Research Centre (IDRC) Digital Library (Canada)

21 juil. 2016 ... Bien que la croissance ait été modérée ces dernières années, on s'attend à ce qu'elle reprenne bientôt. On observe toutefois des ... L'un des principaux enjeux est le fait que l'économie de l'Afrique s'est développée sans qu'aucune transformation structurelle n'ait été apportée. Les experts ont souligné ...

21 CFR 186.1555 - Japan wax.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Japan wax. 186.1555 Section 186.1555 Food and Drugs... Substances Affirmed as GRAS § 186.1555 Japan wax. (a) Japan wax (CAS Reg. No. 8001-39-6), also known as Japan... fruits of the oriental sumac, Rhus succedanea (Japan, Taiwan, and Indo-China), R. vernicifera (Japan...

Hoved-hals-kræft-patienters oplevelse af accelererede patientforløb

DEFF Research Database (Denmark)

Junge, Anne Gram; Risør, Mette Bech; Toustrup, Kasper

2010-01-01

Introduktion: I løbet af 2007 lykkedes det Århus Sygehus at accelerere patientforløbene for hovedhalskræftpatienter, så det mediane forløb fra henvisning til behandlingsstart blev halveret til 29 dage. Denne artikel bygger på resultaterne af et kvalitativt studie, som blev iværksat for at undersø...

S:4 )~W:<.. ~ ---1

African Journals Online (AJOL)

I. He who rules rhe sea controls rhe commerce of rhe world, and rhus rhe riches of rhe world, and finallv rhe world ... comprehend rhe ocean and ro use ir for irs own ... We will bury YOU.'4 ... nessed, since the Second World War, a phenome- ... the British geographer, Sir Halford Mackinder, at .... naval construction prog ram.

Safety characteristics of hydrogen at super ambient conditions: lubricant contamination influencing the auto ignition temperature

International Nuclear Information System (INIS)

Liebner, C.; Schroder, V.; Holtappels, K.

2006-01-01

Inventing hydrogen as a commonly used future energy carrier the long term social acceptance as well as the clean energy image strongly depends upon the safety of its applications. The safety characteristics of hydrogen build a special challenge e.g. in the field of combustion engine development. Small impurities from lubricants used in motors and pumps, may serve as radical source, strongly influencing the auto ignition temperature of hydrogen. Auto Ignition Temperature (AIT) of Hydrogen-Air mixtures were measured in closed autoclaves made from stainless steel, similar to the closed bomb method described in the European standard EN 1839. Initial pressures of 10 bar(a) and 30 bar(a) of a premixed stoichiometric hydrogen-air mixture were investigated. Auto ignition can be obtained about 100 K below the standard AIT (560 deg C, atmospheric pressure) and 300 K below the standard AIT when contaminated through motor oil. (authors)

Molecular detection with terahertz waves based on absorption-induced transparency metamaterials

Science.gov (United States)

G. Rodrigo, Sergio; Martín-Moreno, L.

2016-10-01

A system for the detection of spectral signatures of chemical compounds at the Terahertz regime is presented. The system consists on a holey metal film whereby the presence of a given substance provokes the appearance of spectral features in transmission and reflection induced by the molecular specimen. These induced effects can be regarded as an extraordinary optical transmission phenomenon called absorption-induced transparency (AIT). The phenomenon consist precisely in the appearance of peaks in transmission and dips in reflection after sputtering of a chemical compound onto an initially opaque holey metal film. The spectral signatures due to AIT occur unexpectedly close to the absorption energies of the molecules. The presence of a target, a chemical compound, would be thus revealed as a strong drop in reflectivity measurements. We theoretically predict the AIT based system would serve to detect amounts of hydrocyanic acid (HCN) at low rate concentrations.

Undersøgelsen af brugernes evaluering af kontorpakker på Århus Sygehus og i Psykiatrien i Århus

DEFF Research Database (Denmark)

Hørlück, Jens

En analyse af brugernes opfattelse af kvaliteten af tre office pakker: MS Office 2003 / 2007 og OpenOffice.  ......En analyse af brugernes opfattelse af kvaliteten af tre office pakker: MS Office 2003 / 2007 og OpenOffice.  ...

Research project on “A Study in Urban Air Pollution Improvement in Asia”

OpenAIRE

2017-01-01

This final report of the joint research project “A study in urban air pollution improvement in Asia” is submitted by the Asian Institute of Technology (AIT) on behalf of the project team following the contract between AIT and the Japan International Cooperation Agency (JICA) for the project period of March 2015 - December 2017. Technical support is provided by the Asia Center for Air Pollution Research (ACAP) Japan and the operational support is provided by the Pollution Control Department (P...

Allergen immunotherapy for insect venom allergy

DEFF Research Database (Denmark)

Dhami, S; Zaman, H; Varga, E-M

2016-01-01

BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines on Allergen Immunotherapy (AIT) for the management of insect venom allergy. To inform this process, we sought to assess the effectiveness, cost-effectiveness and safety...... of AIT in the management of insect venom allergy. METHODS: We undertook a systematic review, which involved searching 15 international biomedical databases for published and unpublished evidence. Studies were independently screened and critically appraised using established instruments. Data were...

Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma

DEFF Research Database (Denmark)

Aguilar-Pimentel, Juan Antonio; Graessel, Anke; Alessandrini, Francesca

2017-01-01

)-induced allergic airway inflammation and allergen-specific immunotherapy was combined with the administration of Tofacitinib (TOFA, a FDA-approved JAK inhibitor) from 48 hours prior to 48 hours after therapeutic OVA-injection. The effect of TOFA on human FOXP3+CD4+ T cells was studied in vitro. RESULTS: AIT...... combined with short-term TOFA administration was significantly more effective in suppressing total cell and eosinophil infiltration into the lung, local cytokine production including IL-1β and CXCL1 and showed a trend for the reduction of IL-4, IL-13, TNF-α and IL-6 compared to AIT alone. Furthermore, TOFA...... co-administration significantly reduced systemic IL-6, IL-1β and OVA-specific IgE levels and induced IgG1 to the same extent as AIT alone. Additionally, TOFA enhanced the induction of human FOXP3+CD4+ T cells. CONCLUSIONS: This proof of concept study shows that JAK inhibition did not inhibit...

Forretningsargumenter for mangfoldighedsledelse

DEFF Research Database (Denmark)

Lauring, Jakob

2004-01-01

virksomheden bedre adgang til talent, bedre markedskendskab, innovation og kreativitet. Men der er foretaget meget få konkrete undersøgelser på området. Derfor er der i forbindelse med et ph.d. projekt på Handelshøjskolen i Århus foretaget en interviewundersøgelse med formål at kortlægge de fordele som...

Draft Environmental Impact Statement. Space Shuttle Advanced Solid Rocket Motor Program

Science.gov (United States)

1988-12-01

species, including orchids ( Orchidaceae ) and several carnivorous plants, such as sundews (Drosera sp.), pitcher plants (Sarracenia sp.) and pipeworts...a dense shrub cover including saw palmetto, sea grape (Coccoloba urifera), wax myrtle (Myrica cerifera), and tough buckthorn (Bumelia tenax) (George...Cherry Prunus serotina Shrubs Galberries Ilex glabra, I. coriacea Wax Myrtle yrica cerifeFa Vines Bamboo Vine Similax laurifolia Poison Ivy Rhus radicans

Computerstyret udpegning af svin

DEFF Research Database (Denmark)

Gregersen, Torben; Ahrendt, Peter

2010-01-01

På Ingeniørhøjskolen i Århus har forsknings/udviklingsprojektet IIOSS været i gang siden august 2008, og der er opnået en række bemærkelsesværdige resultater. Blandt disse er der udviklet et computerbaseret kamerasystem system, som holder styr på hvor i stalden et slagtesvin eller en so befinder ...

The Ruben Collection

DEFF Research Database (Denmark)

Nielsen, Steen Kaargaard

2009-01-01

Engelsksproget informationsvideo (4:20) udarbejdet i samarbejde med Statsbiblioteket, Århus (Ole Bisbjerg, Maria Hvid Stenalt), og tilgængelig på følgende web-adresser: http://www.pia.gov.ph/wdavh2009/?m=3&i=denmark&sm=events (Unesco World Day for Audio-Visual Heritage 27 October 2009) http://www.youtube.......com/watch?v=edqr0SlScZc (youtube.com)...

The Rare Perennial Balduina atropurpurea (Asteraceae) at Fort Stewart, Georgia

Science.gov (United States)

1998-06-01

Pinckneya pubens. HAIRY FEVER TREE Rhus copallina. WINGED SUMAC Vaccinium corymbosum . HIGHBUSH BLUEBERRY Tree species Acer rubrum. RED MAPLE...described as non-alluvial wetlands. These are communities with variable hydroperiods occurring in basins or depressions , or on slopes, with no...which may result in inbreeding depression (e.g., Ellstrand, Torres, and Levin 1978; Lande 1988; Watkins and Levin 1990; Ellstrand and Elam 1993

Når "godt gået" betyder "dumt gjort"

DEFF Research Database (Denmark)

Weed, Ethan

2009-01-01

Personer med højre-hemisfærelæsioner kan have problemer med at forstå sprog i kontekst; bl.a. forståelsen og produktion af ironisk og humoristisk sprogbrug og indirekte spørgsmål kan blive påvirket. Et forskningsprojekt i Århus og Hammel kigger på årsagerne til de pragmatiske problemer som person...

Planetary Pledge Pyramid, Facebook Application

DEFF Research Database (Denmark)

2009-01-01

Create an Advert X Alt skal væk NU Macbook Air solgt til 370,- kr. Acer Ferrari ONE 200 solgt til 374,- kr. på Ziinga.dk. - Klik her – Like Unlike You like this. X Mindstep | Useful Training® Interesseret i NLP og i at forbedre din bundlinie markant? Nyt NLP Business Practitioner hold i Århus, 19...

Text condensation in consecutive interpreting - summary of a Ph.d.-dissertation

OpenAIRE

Dam, Helle Vrønning

1996-01-01

Artiklen er et resumé af en Ph.d.-afhandling med titlen 'Tekstkondensering i foredragstolkning', som blev indleveret ved Det Erhvervssproglige Fakultet, Handelshøjskolen i Århus, i oktober 1995. I artiklen skitseres den valgte interdisciplinære tilgang til det fænomen, der undersøges i afhandlingen, ligesom de anvendte metoder og analysemodeller præsenteres.

Essential oils of Curcuma aromatica Salisb. from Northeast India

NARCIS (Netherlands)

Bordoloi, A.K.; Sperkova, J.; Leclercq, P.A.

1999-01-01

The essential oils obtained by steam distillation of the leaves and rhizomes of cultivated Curcuma aromatiea Salisb. were investigated by GC and GC/MS. About 50 compounds have been identified in these oils, accounting for more than 85% of the contents. The major constituents of the leaf oil were

Application of photonics in next generation telecommunication satellites payloads

Science.gov (United States)

Anzalchi, J.; Inigo, P.; Roy, B.

2017-11-01

Next generation broadband telecommunication satellites are required to provide very high data throughput using complex multibeam architectures. These high throughput `Terabit/s' Satellites will incorporate payloads with very large quantity of conventional RF equipment, co-axial cables, waveguides, harnesses and ancillary equipment, making the Assembly, Integration and Test (AIT) very complex. Use of `RF over Fiber' and associated photonics equipment can make the process of AIT much simpler with the added benefit of significant reduction in number of payload equipment and inherent payload mass.

[Protecting Safety During Dust Fires and Dust Explosions - The Example of the Formosa Fun Coast Water Park Accident].

Science.gov (United States)

Hsieh, Ming-Hong; Wu, Jia-Wun; Li, Ya-Cing; Tang, Jia-Suei; Hsieh, Chun-Chien

2016-02-01

This paper will explore the fire and explosion characteristics of cornstarch powder as well as strategies for protecting the safety of people who are involved a dust fire or dust explosion. We discuss the 5 elements of dust explosions and conduct tests to analyze the fire and explosion characteristics of differently colored powders (yellow, golden yellow, pink, purple, orange and green). The results show that, while all of the tested powders were difficult to ignite, low moisture content was associated with significantly greater risks of ignition and flame spread. We found the auto-ignition temperature (AIT) of air-borne cornstarch powder to be between 385°C and 405°C, with yellow-colored cornstarch powder showing the highest AIT and pink-colored cornstarch powder showing the lowest AIT. The volume resistivity of all powder samples was approximately 108 Ω.m, indicating that they were nonconductive. Lighters and cigarettes are effective ignition sources, as their lit temperatures are higher than the AIT of cornstarch powder. In order to better protect the safety of individuals at venues where cornstarch powder is released, explosion control measures such as explosion containment facilities, vents, and explosion suppression and isolation devices should be installed. Furthermore, employees that work at these venues should be better trained in explosion prevention and control measures. We hope this article is a reminder to the public to recognize the fire and explosion characteristics of flammable powders as well as the preventive and control measures for dust explosions.

Face-selective regions differ in their ability to classify facial expressions.

Science.gov (United States)

Zhang, Hui; Japee, Shruti; Nolan, Rachel; Chu, Carlton; Liu, Ning; Ungerleider, Leslie G

2016-04-15

Recognition of facial expressions is crucial for effective social interactions. Yet, the extent to which the various face-selective regions in the human brain classify different facial expressions remains unclear. We used functional magnetic resonance imaging (fMRI) and support vector machine pattern classification analysis to determine how well face-selective brain regions are able to decode different categories of facial expression. Subjects participated in a slow event-related fMRI experiment in which they were shown 32 face pictures, portraying four different expressions: neutral, fearful, angry, and happy and belonging to eight different identities. Our results showed that only the amygdala and the posterior superior temporal sulcus (STS) were able to accurately discriminate between these expressions, albeit in different ways: the amygdala discriminated fearful faces from non-fearful faces, whereas STS discriminated neutral from emotional (fearful, angry and happy) faces. In contrast to these findings on the classification of emotional expression, only the fusiform face area (FFA) and anterior inferior temporal cortex (aIT) could discriminate among the various facial identities. Further, the amygdala and STS were better than FFA and aIT at classifying expression, while FFA and aIT were better than the amygdala and STS at classifying identity. Taken together, our findings indicate that the decoding of facial emotion and facial identity occurs in different neural substrates: the amygdala and STS for the former and FFA and aIT for the latter. Published by Elsevier Inc.

Under-reporting of tuberculosis in Praia, Cape Verde, from 2006 to 2012.

Science.gov (United States)

Furtado da Luz, E; Braga, J U

2018-03-01

According to World Health Organization (WHO) estimates, the under-reporting rate for tuberculosis (TB) in Cape Verde between 2006 and 2012 was 49%. However, the WHO recognises the challenges associated with this estimation process and recommends implementing other methods, such as record linkage, to combat TB under-reporting. To estimate and analyse under-reporting of cases by TB surveillance health units and to evaluate TB cases retrieved from other TB diagnostic sources in Praia, Cape Verde, from 2006 to 2012. This cross-sectional study evaluated under-reporting using the following data: 1) the under-reporting index from TB reporting health units (RHUs), where the number of validated TB cases from RHUs was compared with data from the National Programme for the Fight against Tuberculosis and Leprosy (NPFTL); and 2) the under-reporting index among overall data sources, or a comparison of the number of all validated TB cases from all sources with NPFTL data. The TB under-reporting rate was 40% in Praia during the study period, and results were influenced by laboratory findings. The TB under-reporting rate was very similar to the rate estimated by the WHO. TB surveillance must be improved to reduce under-reporting.

Are French -ité Suffixed Nouns Property Nouns?

OpenAIRE

Koehl, Aurore

2008-01-01

International audience; The aim of this paper is to analyse French deadjectival –ité nouns construction (AitéN), from a lexematic point of view. –ité nouns are the most frequent deadjectival nouns stored in French dictionaries. Most of the time, these nouns are analysed as denoting properties. The present analysis will show that it is not always the case. We propose here a study conducted on 499 AitéN coined on denominal adjectives. We will make use of both syntactic and semantic adjectival p...

Hypoallergenic molecules for subcutaneous immunotherapy.

Science.gov (United States)

Jongejan, Laurian; van Ree, Ronald; Poulsen, Lars K

2016-01-01

Although a large part of the population suffers from allergies, a cure is not yet available. Allergen-specific immunotherapy (AIT) offers promise for these patients. AIT has proven successful in insect and venom allergies; however, for food allergy this is still unclear. In this editorial we focus on the recent advances in a proof of concept study in food allergy, FAST (Food allergy specific immunotherapy), which may increase interest within the biomolecular and pharmaceutical industry to embark on similar projects of immunology driven precision medicine within the allergy field.

Hypoallergenic molecules for subcutaneous immunotherapy

DEFF Research Database (Denmark)

Jongejan, Laurian; van Ree, Ronald; Poulsen, Lars K

2016-01-01

Although a large part of the population suffers from allergies, a cure is not yet available. Allergen-specific immunotherapy (AIT) offers promise for these patients. AIT has proven successful in insect and venom allergies; however, for food allergy this is still unclear. In this editorial we focus...... on the recent advances in a proof of concept study in food allergy, FAST (Food allergy specific immunotherapy), which may increase interest within the biomolecular and pharmaceutical industry to embark on similar projects of immunology driven precision medicine within the allergy field....

Producción de biomasa verde y calidad de aceites esenciales de palmarosa (Cymbopogon martini Roxb.) con aplicación de fertilizantes de síntesis y orgánicos

OpenAIRE

Javier Alberto Pinzón-Torres; Nelson Jovany Contreras Porras; Diego Camilo Durán García; Jairo René Martínez Morales; Elena Stashenko

2014-01-01

El uso de fertilizantes minerales en cultivos de Cymbopogon martini Roxb. (Palmarosa) con el fin de incrementar la biomasa y el rendimiento de aceite esencial (AE) es una práctica cada vez más frecuente. Este aceite es rico en geraniol y acetato de geranilo, moléculas con alto valor en las industrias de productos cosméticos y farmacéutica. Las plantas fueron obtenidas del Centro Nacional de Investigación Agroindustrial de Plantas Aromaticas y Medicinales de la Universidad Industrial de Santan...

Utilisation of Wearable Computing for Space Programmes Test Activities Optimasation

Science.gov (United States)

Basso, V.; Lazzari, D.; Alemanni, M.

2004-08-01

New technologies are assuming a relevant importance in the Space business domain also in the Assembly Integration and Test (AIT) activities allowing process optimization and capability that were unthinkable only few years ago. This paper has the aim to describe Alenia Spazio (ALS) gained experience on the remote interaction techniques as a results of collaborations established both on European Communities (EC) initiatives, with Alenia Aeronautica (ALA) and Politecnico of Torino (POLITO). The H/W and S/W components performances increase and costs reduction due to the home computing massive utilization (especially demanded by the games business) together with the network technology possibility (offered by the web as well as the hi-speed links and the wireless communications) allow today to re-think the traditional AIT process activities in the light of the multimedia data exchange: graphical, voice video and by sure more in the future. Aerospace business confirm its innovation vocation which in the year '80 represents the cradle of the CAD systems and today is oriented to the 3D data visualization/ interaction technologies and remote visualisation/ interaction in collaborative way on a much more user friendly bases (i.e. not for specialists). Fig. 1 collects AIT extended scenario studied and adopted by ALS in these years. ALS experimented two possibilities of remote visualization/interaction: Portable [e.g. Fig.2 Personal Digital Assistant (PDA), Wearable] and walls (e.g.VR-Lab) screens as both 2D/3D visualisation and interaction devices which could support many types of traditional (mainly based on EGSE and PDM/CAD utilisation/reports) company internal AIT applications: 1. design review support 2. facility management 3. storage management 4. personnel training 5. integration sequences definition 6. assembly and test operations follow up 7. documentation review and external access to AIT activities for remote operations (e.g. tele-testing) EGSE Portable Clean room

Sublingual versus subcutaneous immunotherapy: patient adherence at a large German allergy center

Directory of Open Access Journals (Sweden)

Lemberg M

2017-01-01

Full Text Available Marie-Luise Lemberg,1 Till Berk,2 Kija Shah-Hosseini,1 Elena-Manja Kasche,1,3 Ralph Mösges1 1Faculty of Medicine, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany; 2Department of Trauma Surgery, University Hospital Zurich, Zurich, Switzerland; 3Center for Dermatology, Specific Allergology and Environmental Medicine, Hamburg, Germany Background: Many placebo-controlled studies have demonstrated that allergen immunotherapy (AIT is an effective therapy for treating allergies. Both commonly used routes, subcutaneous (SCIT and sublingual immunotherapy (SLIT, require high patient adherence to be successful. In the literature, numbers describing adherence vary widely; this investigation compares these two routes of therapy directly.Methods: All data were retrieved from the patient data management system of a center for dermatology, specific allergology, and environmental medicine in Germany. All 330 patients (aged 13–89 years included in this study had commenced AIT between 2003 and 2011, thus allowing a full 3-year AIT cycle to be considered for each investigated patient.Results: In this specific center, SCIT was prescribed to 62.7% and SLIT to 37.3% of all included patients. The total dropout rate of the whole patient cohort was 34.8%. Overall, SLIT patients showed a higher dropout rate (39.0% than did SCIT patients (32.4%; however, the difference between these groups was not significant. Also, no significant difference between the overall dropout rates for men and for women was observed. A Kaplan–Meier curve of the patient collective showed a remarkably high dropout rate for the first year of therapy.Conclusion: The analysis presented in this single-center study shows that most patients who discontinue AIT do so during the first year of therapy. Patients seem likely to finish the 3-year therapy cycle if they manage to adhere to treatment throughout the first year. Strategies for preventing

Budget impact analysis of two immunotherapy products for treatment of grass pollen-induced allergic rhinoconjunctivitis

Directory of Open Access Journals (Sweden)

Rønborg SM

2012-09-01

Full Text Available Steen M Rønborg,1 Ulrik G Svendsen,2 Jesper S Micheelsen,3 Lars Ytte,4 Jakob N Andreasen,5 Lars Ehlers61The Pulmonology and Allergy Clinic of Copenhagen, Copenhagen, 2Bispebjerg Hospital, Copenhagen, 3Private ENT practice, Aalborg, 4General Practice Aalborg, 5ALK, Hørsholm, 6Aalborg University, Aalborg, DenmarkBackground: Grass pollen-induced allergic rhinoconjunctivitis constitutes a large burden for society. Up to 20% of European and United States (US populations suffer from respiratory allergies, including grass pollen-induced allergic rhinoconjunctivitis. The majority of patients are treated with symptomatic medications; however, a large proportion remains uncontrolled despite use of such treatments. Specific immunotherapy is the only treatment documented to target the underlying cause of the disease, leading to a sustained effect after completion of treatment. The aim of this study was to compare the economic consequences of treating patients suffering from allergic rhinoconjunctivitis with either a grass allergy immunotherapy tablet (AIT or subcutaneous immunotherapy (SCIT.Methods: A budget impact analysis was applied comparing SQ-standardized grass AIT (Grazax®; Phleum pratense, 75,000 SQ-T/2,800 BAU; ALK, Denmark with SCIT (Alutard®; P. pratense, 100,000 SQ-U/mL; ALK, Denmark. Budget impact analysis included health care utilization measured in physical units based on systematic literature reviews, guidelines, and expert opinions, as well as valuation in unit costs based on drug tariffs, physician fees, and wage statistics. Budget impact analysis was conducted from a Danish health care perspective.Results: Treating patients suffering from allergic rhinoconjunctivitis with grass AIT instead of grass SCIT resulted in a total reduction in treatment costs of €1291 per patient during a treatment course. This cost saving implies that approximately 40% more patients could be treated with grass AIT per year without influencing the cost of

The GenDev Curriculum Development Workshop.

Science.gov (United States)

D'cunha, J

1997-01-01

This article describes the second Curriculum Development Workshop held in May 1997 at the Asian Institute of Technology (AIT) in Bangkok, Thailand. The workshop aimed to review critically and restructure the Gender and Development Studies (GenDev) curriculum and to assess AIT's role in training gender experts for the region. Participants included 22 people from 16 countries in Asia, Europe, and the US who were teaching graduate students about gender issues and who were activists with nongovernmental organizations working on gender issues. It was determined that the following were required courses: Culture, Knowledge and Gender Relations; Gender, Technology, and Development; Principles of Gender Research and Methodology in Science and Technology; and Gender Analysis and Field Methods. Other suggested core courses included: Gender and Natural Resource Management; Enterprise Management, Technology, and Gender; Gender and Agrarian Reform; Urbanization: A Gender Perspective; Gender-Responsive Development Planning; and Gender and Economic Change: Past and Present Concerns. Participants distinguished between GenDev courses offered to anyone attending AIT and training courses designed to produce gender experts in the region. The aim of training courses for AIT graduate students was to sensitize potential managers, technologists, and others on gender issues and to create awareness of the importance of including gender perspectives within decision-making, policy formation, and implementation. Training courses to produce gender experts should be directed to those with a prior background in gender studies and include gender analysis in field methods. Participants agreed that there should be an independent and autonomous field of gender and development studies. Participants made six recommendations for such a field of study.

Weight loss is superior to exercise in improving the atherogenic lipid profile in a sedentary, overweight population with stable coronary artery disease

DEFF Research Database (Denmark)

Pedersen, Lene Rørholm; Olsen, Rasmus Huan; Anholm, Christian

2016-01-01

disease (CAD). METHODS: Seventy non-diabetic participants with CAD, BMI 28-40 kg/m(2), age 45-75 years were randomized to 12 weeks' aerobic interval training (AIT) at 85-90% of peak heart rate three times/week or a low energy diet (LED, 800-1000 kcal/day) for 8-10 weeks followed by 2-4 weeks' weight...... maintenance diet. Lipid profile atherogenicity was described using lipoprotein particle size and density profiling. Low-grade inflammation was evaluated by tumor necrosis factor alpha (TNFα), C-reactive protein, interleukin 6 and soluble urokinase plasminogen activator receptor. RESULTS: Twenty-six (74%) AIT...

Auditory Integration Training

Directory of Open Access Journals (Sweden)

Zahra Jafari

2002-07-01

Full Text Available Auditory integration training (AIT is a hearing enhancement training process for sensory input anomalies found in individuals with autism, attention deficit hyperactive disorder, dyslexia, hyperactivity, learning disability, language impairments, pervasive developmental disorder, central auditory processing disorder, attention deficit disorder, depressin, and hyperacute hearing. AIT, recently introduced in the United States, and has received much notice of late following the release of The Sound of a Moracle, by Annabel Stehli. In her book, Mrs. Stehli describes before and after auditory integration training experiences with her daughter, who was diagnosed at age four as having autism.

Review: Auditory Integration Training

Directory of Open Access Journals (Sweden)

Zahra Ja'fari

2003-01-01

Full Text Available Auditory integration training (AIT is a hearing enhancement training process for sensory input anomalies found in individuals with autism, attention deficit hyperactive disorder, dyslexia, hyperactivity, learning disability, language impairments, pervasive developmental disorder, central auditory processing disorder, attention deficit disorder, depression, and hyper acute hearing. AIT, recently introduced in the United States, and has received much notice of late following the release of the sound of a miracle, by Annabel Stehli. In her book, Mrs. Stehli describes before and after auditory integration training experiences with her daughter, who was diagnosed at age four as having autism.

Cultural Resources Survey of Three Iberville Parish Levee Enlargement and Revetment Construction Items

Science.gov (United States)

1993-09-22

elm (Ulmus), and pecan (Carya illlnoensis) may occur at higher elevations. Poison ivy (Rhus radicans), Virginia and trumpet creeper (Parthenocissus sp... pecans were produced In the parish. Cotton, grown during the early 1900s, had all but disappeared by 1940. Soybeans, initially planted with corn to...Holland and England are known as de Equivalents in Italy , Iberia, and Mexico are called muioica. Tin glazed earthenware has a soft porous paste

Phytotherapy in Functional Gastrointestinal Disorders.

Science.gov (United States)

Kelber, Olaf; Bauer, Rudolf; Kubelka, Wolfgang

2017-01-01

Phytotherapy is an important therapeutic option in functional gastrointestinal diseases (FGID). It has a large tradition, with different approaches in different regions of the world, some of which have made their way into modern evidence-based medicine (EBM). Taking into account the number of herbs in use, and also the cumulated scientific evidence on them, FGID are possibly the most important indication in phytotherapy. This does not only apply for European phytotherapy, but also for other regions, such as Asia. Within European phytotherapy, herbs active in FGID are usually classified according to their main active constituents and their activities. Typically, the herbs used in FGID are grouped into amara, aromatica, amara aromatica combining both properties, herbs stimulating gastric secretion, herbs containing spasmolytic and carminative essential oils or spasmolytic alkaloids, mucilaginosa soothing the mucosa, and flavonoid containing drugs with anti-inflammatory properties. In phytotherapy, different plants are frequently combined to maximize effectiveness and specificity of action. Very potent combination products can be developed when the mechanisms of action of the combination partners are complementary. This approach can be demonstrated by the example of STW 5. For this herbal combination product, therapeutic efficacy in FGID has been clinically proven according to the highest standards of EBM. This example also underlines that modern rational phytotherapy is definitely part of modern EBM. Key Messages: FGID is one of the most important indications in phytotherapy and rationally combined herbal preparations are established evidence-based therapeutic options. © 2018 The Author(s) Published by S. Karger AG, Basel.

Ação antioxidante de chás e condimentos de grande consumo no Brasil

Directory of Open Access Journals (Sweden)

Selene M. de Morais

Full Text Available Antioxidantes são compostos que atuam inibindo e/ou diminuindo os efeitos desencadeados pelos radicais livres e compostos oxidantes. Os chás são bebidas populares e fontes significativas de compostos fenólicos, sendo considerados importantes integrantes das dietas devido às suas propriedades antioxidantes. O presente trabalho teve como objetivo avaliar a ação antioxidante de uma variedade de chás e condimentos mais consumidos no Brasil. Os chás analisados foram das plantas: Pneumus boldus Mold., Matricaria recutita L., Cymbopogon citratus (DC Stapf, Baccharis trimera (Less. DC, Camelia sinensis (L O. Kuntze (fermentado, Camelia sinensis (não-fermentado, Lippia alba N.E. Brown,Mentha arvensis L., e Pyrus malus L. Os condimentos analisados foram: Eugenia aromatica Baill, Cinnamonum zeylanicum Blume, Laurus nobilis L. e Origanum vulgare L. O método utilizado para avaliar a ação antioxidante foi o da atividade seqüestradora de radicais livres DPPH em solução metanólica. Todas as amostras analisadas demonstraram atividade em suas diferentes concentrações. Camelia sinensis (não-fermentada foi a mais ativa com CI50= 0,14 mg/mL, cujos principais compostos antioxidantes são epigalocatequinas. Os condimentos mais ativos foram Cinnamonum zeylanicum (CI50 = 0,37 mg/mL, Eugenia aromatica Baill (CI50 = 0,46 mg/mL e Laurus nobilis (CI50 = 0,76 mg/mL, cujo principal antioxidante relatado foi o eugenol.

Immunotherapy of allergic contact dermatitis.

Science.gov (United States)

Spiewak, Radoslaw

2011-08-01

The term 'immunotherapy' refers to treating diseases by inducing, enhancing or suppressing immune responses. As allergy is an excessive, detrimental immune reaction to otherwise harmless environmental substances, immunotherapy of allergic disease is aimed at the induction of tolerance toward sensitizing antigens. This article focuses on the historical developments, present state and future outlook for immunotherapy with haptens as a therapeutic modality for allergic contact dermatitis. Inspired by the effectiveness of immunotherapy in respiratory allergies, attempts were undertaken at curing allergic contact dermatitis by means of controlled administration of the sensitizing haptens. Animal and human experiments confirmed that tolerance to haptens can be induced most effectively when the induction of tolerance precedes attempted sensitization. In real life, however, therapy is sought by people who are already sensitized and an effective reversal of hypersensitivity seems more difficult to achieve. Decades of research on Rhus hypersensitivity led to a conclusion that immunotherapy can suppress Rhus dermatitis, however, only to a limited degree, for a short period of time, and at a high risk of side effects, which makes this method therapeutically unprofitable. Methodological problems with most available studies of immunotherapy of contact allergy to nickel make any definite conclusions impossible at this stage.

Changes in markers associated with dendritic cells driving the differentiation of either TH2 cells or regulatory T cells correlate with clinical benefit during allergen immunotherapy.

Science.gov (United States)

Gueguen, Claire; Bouley, Julien; Moussu, Hélène; Luce, Sonia; Duchateau, Magalie; Chamot-Rooke, Julia; Pallardy, Marc; Lombardi, Vincent; Nony, Emmanuel; Baron-Bodo, Véronique; Mascarell, Laurent; Moingeon, Philippe

2016-02-01

Regulatory dendritic cell (DC) markers, such as C1Q, are upregulated in PBMCs of patients with grass pollen allergy exhibiting clinical benefit during allergen immunotherapy (AIT). We sought to define markers differentially expressed in human monocyte-derived DCs differentiated toward a proallergic (DCs driving the differentiation of TH2 cells [DC2s]) phenotype and investigate whether changes in such markers in the blood correlate with AIT efficacy. Transcriptomes and proteomes of monocyte-derived DCs polarized toward DCs driving the differentiation of TH1 cells (DC1s), DC2s, or DCs driving the differentiation of regulatory T cells (DCreg cells) profiles were compared by using genome-wide cDNA microarrays and label-free quantitative proteomics, respectively. Markers differentially regulated in DC2s and DCreg cells were assessed by means of quantitative PCR in PBMCs from 80 patients with grass pollen allergy before and after 2 or 4 months of sublingual AIT in parallel with rhinoconjunctivitis symptom scores. We identified 20 and 26 new genes/proteins overexpressed in DC2s and DCreg cells, respectively. At an individual patient level, DC2-associated markers, such as CD141, GATA3, OX40 ligand, and receptor-interacting serine/threonine-protein kinase 4 (RIPK4), were downregulated after a 4-month sublingual AIT course concomitantly with an upregulation of DCreg cell-associated markers, including complement C1q subcomponent subunit A (C1QA), FcγRIIIA, ferritin light chain (FTL), and solute carrier organic anion transporter family member 2B1 (SLCO2B1), in the blood of clinical responders as opposed to nonresponders. Changes in such markers were better correlated with clinical benefit than alterations of allergen-specific CD4(+) T-cell or IgG responses. A combination of 5 markers predominantly expressed by blood DCs (ie, C1Q and CD141) or shared with lymphoid cells (ie, FcγRIIIA, GATA3, and RIPK4) reflecting changes in the balance of regulatory/proallergic responses

Empiric 131I treatment of high thyroglobulin levels in differentiated thyroid carcinoma after remnant ablation

International Nuclear Information System (INIS)

Kalender, E.; Elboga, U.; Celen, Y.; Demir, H.; Yilmaz, M.; Sahin, E.

2015-01-01

Full text of publication follows. Objective: serum thyroglobulin (Tg) measurements are usually the best marker of residual or metastatic disease after the treatment of differentiated thyroid carcinoma (DTC). It is not rare to find patients with detectable serum Tg levels after ablative 131 I treatment (AIT). The objective of this study is to establish the efficacy of empiric 131 I treatment (EIT) given for patients whose Tg levels remained high after AIT. Materials and methods: 28 patients (23 women, 5 men; mean age 47.4 ± 16.8) without distant metastasis, who were treated empirically for high Tg levels after AIT in our clinic were studied retrospectively. In all patients stimulated Tg levels before AIT (Tg I) and 6 months after AIT (Tg II) were measured. The Tg cutoff level for EIT was accepted 10 ng/ml. After EIT, post-therapeutic whole-body scintigraphy (PWBS) was performed to all patients. 18 F-FDG PET CT was performed to patients who had negative PWBS but continued high Tg II levels. Results: PWBS was positive in 14 patients (50%) and negative in 14 patients (50%). 14 patients did not respond to EIT (50%), and 14 patients (50%) responded to EIT at different rates. Eight patients (28.6%) responded to EIT completely, and 6 patients (21.4%) responded to EIT partially. Tg I was 60.7 ± 40 ng/ml and Tg II was 31 ± 20.4 ng/ml in responded patients. Tg I was 87.6 ± 96 ng/ml and Tg II was 114.3 ± 106 ng/ml in non-responding patients. 18 F-FDG PET CT was performed to 14 patients who had negative PWBS. 18 F-FDG PET CT was positive in 11 patients and negative in 3 patients. 18 F-FDG PET CT positive patients were referred to surgery. Conclusion: Our findings, suggested that the EIT is not beneficial in patients who have higher Tg II than Tg I and the cure rate is low in increasing Tg levels. The patients who have high Tg II but lower than Tg I can be treated empirically with 131 I. In these patients EIT may be beneficial. (authors)

The Characteristics of Amiodarone-induced Thyrotoxicosis in a Moderate Iodine Deficit Area

Directory of Open Access Journals (Sweden)

Ancuța-Elena Cota

2013-08-01

Full Text Available Introduction: Amiodarone (AMI, a class III anti-arrhythmic drug, is associated with a number of side effects, including thyroid dysfunction (both hypo- and hyperthyroidism, which is due to amiodarone's high iodine content and its direct toxic effect on the thyroid. Objective: To evaluate the incidence of Amiodarone induced thyrotoxicosis (AIT (type, rate of occurrence and to identify the risk factors involved in its occurrence. Material and method: We examined patients treated with amiodarone, between January 2002 and December 2011, who presented to our Department of Endocrinology Târgu Mures for thyroid dysfunctions. Results: The retrospective study included 87 patients with thyroid dysfunctions; 58 (66.7% patients had AIT and 29 (33.3% had Amiodarone induced hypothyroidism (AIH. In the AIT group: 35 were women (60.3%, 23 were men (39.7%; the average age was 61.60 ± 12.39 years. Risk factors identified for the AIT group were male gender (RR = OR = 3.8; Chi-squer = 5.7, p = 0.004 and pre-existing thyroid abnormalities (RR = 2.5, Chi-square = 4.1, p = 0.005. The thyroid dysfunction occurrence was heterogeneous (0.2-183 months. The patients with previous thyroid abnormalities developed earlier thyroid dysfunction compared to those with an apparently normal thyroid gland (22.25 ± 4.14 months versus 32.09 ± 7.69 months, p = 0.02, T test. Conclusion: In the context of the specific iodine geoclimatic intake and the area of origin, amiodarone - induced thyroid dysfunction spectrum is dominated by thyrotoxicosis. Screening and monitoring of thyroid function for patiens under chronic amiodarone treatment is necessary

Aerobic interval exercise improves parameters of nonalcoholic fatty liver disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats.

Science.gov (United States)

Kapravelou, Garyfallia; Martínez, Rosario; Andrade, Ana M; Nebot, Elena; Camiletti-Moirón, Daniel; Aparicio, Virginia A; Lopez-Jurado, Maria; Aranda, Pilar; Arrebola, Francisco; Fernandez-Segura, Eduardo; Bermano, Giovanna; Goua, Marie; Galisteo, Milagros; Porres, Jesus M

2015-12-01

Metabolic syndrome (MS) is a group of metabolic alterations that increase the susceptibility to cardiovascular disease and type 2 diabetes. Nonalcoholic fatty liver disease has been described as the liver manifestation of MS. We aimed to test the beneficial effects of an aerobic interval training (AIT) protocol on different biochemical, microscopic, and functional liver alterations related to the MS in the experimental model of obese Zucker rat. Two groups of lean and obese animals (6 weeks old) followed a protocol of AIT (4 min at 65%-80% of maximal oxygen uptake, followed by 3 min at 50%-65% of maximal oxygen uptake for 45-60 min, 5 days/week, 8 weeks of experimental period), whereas 2 control groups remained sedentary. Obese rats had higher food intake and body weight (P metabolism and increased the liver protein expression of PPARγ, as well as the gene expression of glutathione peroxidase 4 (P < 0.001). The training protocol also showed significant effects on the activity of hepatic antioxidant enzymes, although this action was greatly influenced by rat phenotype. The present data suggest that AIT protocol is a feasible strategy to improve some of the plasma and liver alterations featured by the MS.

Markedsføring af jordbær

DEFF Research Database (Denmark)

Østergaard, Peder

2001-01-01

Emballagen til jordbær bør være forsynet med oplysninger om sorten og dens egenskaber for at fremme salget i supermarkedet, råder MAPP-centret i Århus. Det ideelle vil være en person i grøntafdelingen, der kan fortælle om jordbærrene og besvare spørgsmål. Uddeling af smagsprøver vil også være en ...

Biological Assessment of the Effects of Military Associated Activities on Endangered Species at Fort Hood, Texas

Science.gov (United States)

1992-12-01

monographing the genus Croton. Dr. Joe Allen Farmer published a dissertation on the species in 1962. Studies on the Fort Hood population have begun under...Woodhouse, S.W., "Descriptions of New Species of the Genus Vireo, VieilL, and Zonorrichia, Swains," Proceeding of the Academy of Natural Sciences of...sinuata Skunkbush Saumac Rhus aroma tica Texas Oak Quercus texazza Texas Persimmon, Diospyros texana Texas Ashe Fraxinus texensis Virginia Creeper Paz

Buffalo Metropolitan Area, New York Water Resources Management. Interim Report on Feasibility of Flood Management in Cazenovia Creek Watershed.

Science.gov (United States)

1977-03-01

Ulmus rubra slippery elm Ulmus thomasii rock elm Pinus strobus white pine Juglans cinerea. butternut Juglans nigra black walnut Carya ovata shagbark...West Seneca X : X : X Town of Elm : X X X Town of Aurora : X : Town of Boston X : Town of Colden : X : 5.i, Table 1 (cont’d) Flood Insurance Status for...grandidentata bigtooth aspen Populus deltoides eastern cottonwood Rhus typhina staghorn. sumc Betula alleghaniesis yellow birch Ulmus americana. American elm

ARTÍCULOS ESTUDIANTES - 1. THE PROCESS OF COMMUNICATION BETWEEN MEN AND WOMEN

OpenAIRE

Julie Eleaume

2012-01-01

According to Simone de Beauvoir in Le deuxième Sexe, “Pour être un individu complet, l'égale de l'homme, il faut que la femme ait accès au monde masculin comme le mâle au monde féminin, qu'elle ait accès à l'autre” (1). To become a complete individual, women need to have access to the masculine world, but men also need to have access to the feminine one. And to understand themselves, or to discover the sphere of the other, men and women need to communicate, to let them enter their respective ...

Clinical implications of a new TSH-receptor-antibody-assay (DYNOtest {sup trademark} TRAKhuman) in autoimmune thyroid diseases; Klinische Implikationen eines neuen TSH-Rezeptor-Antikoerper-Assays (DYNOtest {sup trademark} TRAKhuman) bei autoimmunen Schilddruesenerkrankungen

Energy Technology Data Exchange (ETDEWEB)

Meller, J.; Schreivogel, I.; Becker, W. [Goettingen Univ. (Germany). Abt. fuer Nuklearmedizin; Bergmann, A.; Morgenthaler, N. [B.R.A.H.M.S Diagnostica, Berlin (Germany); Huefner, M. [Goettingen Univ. (Germany). Abt. Innere Medizin

2000-07-01

Aim: Conventional radioreceptor-antibody-assays (RAAs) fail in the detection of TSH-receptor antibodies (TRAKs) in 10-30% of patients with Graves' disease (GD). The aim of this study was the evaluation of the diagnostic and clinical impact of a new RRA (DYNOtest {sup trademark} TRAKhuman) which uses the human recombinant TSH-Receptor in the diagnosis of autoimmune thyroid disease. Methods: Sera from 142 consecutive patients (GD: n=50, autoimmune thyroiditis/AIT: n=92) and from 55 controls (31 patients without any thyroid disease and 14 with euthyroid goiter) were evaluated both with the DYNOtest {sup trademark} TRAKhuman-assay and a conventional RRA (TRAK-Assay {sup trademark}). Thyroid in vitro parameters and thyroid sonography were performed in all patients. Results: The DYNOtest {sup trademark} TRAK-assay was significantly superior to the conventional RRA in the diagnosis of GD (p<0,00012), especially in those who were treated by thionamides (p<0,003) and in the diagnosis of TRAK-positive patients with AIT (p<0,003). The majority of TRAK-positive AIT-patients suffered from hypothyroidism. One false positive result in patients with euthyroid goiter was found in the TRAK-Assay {sup trademark} as well as in the DYNOtest {sup trademark} TRAKhuman-Assay. Therefore the specifity of the DYNOtest {sup trademark} TRAKhuman was not inferior compared with the conventional assay. Conclusion: The DYNOtest {sup trademark} TRAK-assay is superior in the diagnostic work up of Graves' disease compared with a conventional TRAK-assay and offers an equal specifity. (orig.) [German] Ziel: Bei konventionellen Radiorezeptor-Antikoerper-Assays (RRAs) misslingt der Nachweis von TSH-Rezeptor Antikoerpern (TRAKS) bei 10-30% der immunogenen Hyperthyreosen (IH). Ziel der Studie war es, den diagnostischen und klinischen Stellenwertes eines neuen RRA (DYNOtest {sup trademark} TRAKhuman) bei autoimmunen Schilddruesenerkrankungen zu evaluieren. Methoden: Serumproben von 142

Musik & Demens

DEFF Research Database (Denmark)

Ridder, Hanne Mette Ochsner

Når vi læser eller hører om demens handler det for det meste om de mange negative konsekvenser ved en demenssygdom, f.eks. om forvildede gamle der først bliver fundet efter dage i vinterkulden eller om manglende omsorg på plejehjem. I Musik & Demens rettes fokus mod ressourceområder hos demensram...... musikterapeut på Plejehjemmet Caritas ved Århus og som ekstern lektor på musikterapiuddannelsen ved Aalborg Universitet....

BASALIT trial: double-blind placebo-controlled allergen immunotherapy with rBet v 1-FV in birch-related soya allergy.

Science.gov (United States)

Treudler, R; Franke, A; Schmiedeknecht, A; Ballmer-Weber, B; Worm, M; Werfel, T; Jappe, U; Biedermann, T; Schmitt, J; Brehler, R; Kleinheinz, A; Kleine-Tebbe, J; Brüning, H; Ruëff, F; Ring, J; Saloga, J; Schäkel, K; Holzhauser, T; Vieths, S; Simon, J C

2017-08-01

Conflicting results exist on the effect of allergen immunotherapy (AIT) on pollen-related food allergy. We aimed to investigate the efficacy of one-year AIT with the folding variant (FV) of recombinant (r) Bet v 1 on birch-related soya allergy. Of 138 subjects with Bet v 1 sensitization, 82 were positive at double-blind placebo-controlled food challenge (DBPCFC) with soya. A total of 56 of 82 were randomized in the ratio of 2:1 (active: placebo). Per-protocol population (PPP) had received ≥150 μg of allergen or placebo preparation. lowest observed adverse effect levels (LOAEL), postinterventional occurrence of objective signs (objS) at any dose level, sIgE/IgG4 against Bet v 1 and Gly m 4. Between-group changes were investigated (ancova, Mann-Whitney U-test, Fisher exact test). Baseline characteristics including LOAELs were comparable in both groups with objS and subjS occurring in 82% and 95% of active (n = 38) vs 78% and 83% of placebo group (n = 18). After AIT, objS occurred in 24% and 47%, respectively. LOAEL group differences showed a beneficial tendency (P = 0.081) for LOAEL objective in PPP (30 active, 15 placebo). sIgG4 raised only in active group (Bet v 1: P = 0.054, Gly m 4: P = 0.037), and no relevant changes occurred for sIgE. Only 56% of the intended sample size was recruited. For the first time, we present data on the effect of rBet v 1-FV on birch-related soya allergy. rBet v 1-FV AIT induced significant immunogenic effects. Clinical assessment showed a tendency in favour of the active group but did not reach statistical significance. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Use of Aromatase Inhibitors in Large Cell Calcifying Sertoli Cell Tumors: Effects on Gynecomastia, Growth Velocity, and Bone Age

Science.gov (United States)

Crocker, Melissa K.; Gourgari, Evgenia; Stratakis, Constantine A.

2014-01-01

Context: Large cell calcifying Sertoli cell tumors (LCCSCT) present in isolation or, especially in children, in association with Carney Complex (CNC) or Peutz-Jeghers Syndrome (PJS). These tumors overexpress aromatase (CYP19A1), which leads to increased conversion of delta-4-androstenedione to estrone and testosterone to estradiol. Prepubertal boys may present with growth acceleration, advanced bone age, and gynecomastia. Objective: To investigate the outcomes of aromatase inhibitor therapy (AIT) in prepubertal boys with LCCSCTs. Design: Case series of a very rare tumor and chart review of cases treated at other institutions. Setting: Tertiary care and referral center. Patients: Six boys, five with PJS and one with CNC, were referred to the National Institutes of Health for treatment of LCCSCT. All patients had gynecomastia, testicular enlargement, and advanced bone ages, and were being treated by their referring physicians with AIT. Interventions: Patients were treated for a total of 6–60 months on AIT. Main Outcome Measures: Height, breast tissue mass, and testicular size were all followed; physical examination, scrotal ultrasounds, and bone ages were obtained, and hormonal concentrations and tumor markers were measured. Results: Tumor markers were negative. All patients had decreases in breast tissue while on therapy. Height percentiles declined, and predicted adult height moved closer to midparental height as bone age advancement slowed. Testicular enlargement stabilized until entry into central puberty. Only one patient required unilateral orchiectomy. Conclusions: Patients with LCCSCT benefit from AIT with reduction and/or elimination of gynecomastia and slowing of linear growth and bone age advancement. Further study of long-term outcomes and safety monitoring are needed but these preliminary data suggest that mammoplasty and/or orchiectomy may be foregone in light of the availability of medical therapy. PMID:25226294

MMT promises: how the Ethyl Corporation beat the federal ban

International Nuclear Information System (INIS)

Schneiderman, S.

1999-01-01

The manganese-based MMT has been blended in gasoline fuel sold in Canada for almost 20 years. Invoking environmental health and consumer protection grounds, the federal government moved to prohibit the importation and inter-provincial trade of MMT in June 1997. Ethyl Corporation of Richmond, Virginia, the sole producers of MMT, claimed discriminatory treatment under NAFTA and sought $ 250 million in damages as compensation for alleged 'expropriation' of the company's investment interests. A stunning reversal of the Canadian government's decision occurred one year later. Canada agreed to pay Ethyl Corporation $ 13 million (representing legal fees and lost profits) and agreed to rescind the legislation and admit publicly that the use of MMT poses no environmental risk. The reversal was the result of the little-known Agreement on Internal Trade (AIT), a federal-provincial government agreement, intended to reduce 'non-tariff' barriers to inter-provincial trade and create greater economic union. The AIT is modelled on NAFTA and the Uruguay-round GATT, and treats relations between the Canadian provinces as if they were relations among sovereign states. In cases of conflict, provinces are entitled to seek resolution of complaints before dispute resolution panels. Some of the provinces voiced objection to the MMT legislation and Alberta, supported by three other provinces, filed an AIT complaint against the federal government for prohibiting the inter-provincial trade of MMT. The AIT dispute panel upheld Alberta's complaint. The decision was hailed as a 'triumph of principle over bad science'. It was an unmitigated success for Ethyl Corporation, and a humiliating defeat for the federal government. In this author's view, the MMT story is a clear example of yet another instrument by which corporate power can limit the capacity of democratically elected governments to act on behalf of the public good

Association of active human herpesvirus-6 (HHV-6) infection with autoimmune thyroid gland diseases.

Science.gov (United States)

Sultanova, A; Cistjakovs, M; Gravelsina, S; Chapenko, S; Roga, S; Cunskis, E; Nora-Krukle, Z; Groma, V; Ventina, I; Murovska, M

2017-01-01

Viral infections frequently have been cited as important environmental factors implicated in the onset of autoimmune thyroiditis (AIT). The aim of this study was to determine the involvement of HHV-6 infection in the development of autoimmune thyroiditis. This study included 45 patients (42 female and 3 male; median age 47.00 IQR 38.50-57.00) with histologically, laboratory, and clinically confirmed autoimmune thyroiditis, as well as 30 autopsied subjects (26 female and 4 male; median age 58.50, IQR 51.50-67.00) without thyroid pathologies and 30 healthy blood donors (25 female and 5 male; median age 33.50, IQR 27.75-44.25) as controls. Results were obtained by applying molecular virology and immunohistochemistry techniques. The presence of persistent HHV-6 infection in AIT patients was significantly higher (p 0.0058) than in the control group (44/45 (98%) vs. 23/30 (77%), respectively). Also, a significantly higher frequency of HHV-6 activation marker (U79/80 mRNA) was found in patients' thyroid gland tissue samples with AIT in comparison with the control group (18/44 (41%) vs. 1/17 (6%), respectively; p 0.0118). The median HHV-6 load was found to be higher in patients with active viral infection than in patients without it (2147, IQR 971-4188 vs. 551, IQR 145-1589 copies/1×10 6 cells; p 0.003). The presence of HHV-6 antigen expression was demonstrated in intrafollicular cellular clusters and immunohistochemistry indicated thyrocytes in the follicle wall. These findings provide evidence of strong HHV-6 infection association with AIT development. Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

SIĞIR AYAKLARININ POSTMORTEM MAKROSKOPİK VE HİSTOPATOLOJİK OLARAK DEĞERLENDİRİLMESİ

OpenAIRE

ÖZSOY, Serhat; ÖZER, Kürşat; ARUN, Seçkin

2018-01-01

ÖzetÖzel bir mezbahadan elde edilen 112 sığıra ait 448 ayağın tırnaklan, makroskopik ve histopatolojik olarak incelendi.Değerlendirilen ayakların 110'u Holstayn, 1'i Simental, 1'i Yerli Kara ırkına ait idi. Bunlardan 89'u erkek, 23'ü dişiydi. Ayakların makroskopik incelemesi sonucunda 38 olguda taban-ökçe çürüğü, 22 olguda taban çürüğü, 29 olguda ökçe çürüğü, 30 olguda kronik-subklinik laminitis, 12 olguda beyaz çizgi ayrılması, 4 olguda interdigital panarisyurn, 6 ol...

Next generation immunotherapy for tree pollen allergies.

Science.gov (United States)

Su, Yan; Romeu-Bonilla, Eliezer; Heiland, Teri

2017-10-03

Tree pollen induced allergies are one of the major medical and public health burdens in the industrialized world. Allergen-Specific Immunotherapy (AIT) through subcutaneous injection or sublingual delivery is the only approved therapy with curative potential to pollen induced allergies. AIT often is associated with severe side effects and requires long-term treatment. Safer, more effective and convenient allergen specific immunotherapies remain an unmet need. In this review article, we discuss the current progress in applying protein and peptide-based approaches and DNA vaccines to the clinical challenges posed by tree pollen allergies through the lens of preclinical animal models and clinical trials, with an emphasis on the birch and Japanese red cedar pollen induced allergies.

Allergen immunotherapy for allergic rhinoconjunctivitis

DEFF Research Database (Denmark)

Nurmatov, Ulugbek; Dhami, Sangeeta; Arasi, Stefania

2017-01-01

Background: The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines on Allergen Immunotherapy (AIT) for Allergic Rhinoconjunctivitis (ARC). To inform the development of recommendations, we sought to critically assess the systematic review evidence on the effective......Background: The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines on Allergen Immunotherapy (AIT) for Allergic Rhinoconjunctivitis (ARC). To inform the development of recommendations, we sought to critically assess the systematic review evidence...... of these were judged to be of high, five moderate and three low quality. These reviews suggested that, in carefully selected patients, subcutaneous (SCIT) and sublingual (SLIT) immunotherapy resulted in significant reductions in symptom scores and medication requirements. Serious adverse outcomes were rare...

Karagöl (Yamanlar, İzmir'ün Sucul Coleoptera (Classis: Insecta Faunasına Katkılar.

Directory of Open Access Journals (Sweden)

Esat Tarık Topkara

2015-12-01

Full Text Available Bu çalışmada, Karagöl (Yamanlar-İzmir’den 18 Mayıs 2006 tarihinde yapılan örnekleme sonucu elde edilen sucul Coleoptera örnekleri değerlendirilmiştir. Sistematik açıdan yapılan değerlendirmede, Adephaga altfamilyasının Gyrinidae ve Dytiscidae familyalarına ait 4 tür, Polyphaga altfamilyasının Helophoridae, Hydrophilidae, Hydraenidae ve Dryopidae familyalarına ait 7 tür tespit edilmiştir. Tespit edilen türler bu gölün sucul Coleoptera faunası için yeni kayıt niteliğindedir

Anti-fibrotic Effects of Rhus javanica Linn (Anacardiaceae) Extract ...

African Journals Online (AJOL)

muscle actin (α-SMA) and platelet-derived growth factor (PDGF) were determined using reverse transcription-polymerase chain reaction (RT-PCR) in HSCs. Protein expression of .... artificial light (12:12-h light: dark cycle, lights on at 0700) with free access to water and feed ad libitum prior to experiments. HSCs were ...

Dietary Rhus coriaria L. powder reduces the blood cholesterol ...

African Journals Online (AJOL)

MORTAZA

SFP and H-SFP birds had lower plasma TC and VLDL-c concentrations than the .... 1Vitamin premix per kg of diet: 2.7 mg vitamin A (retinol); 0.05 mg vitamin D3 .... degradation products are absorbed from the small intestine and caused toxic ...

Phytoconstituents and biological activities of essential Oil from Rhus ...

African Journals Online (AJOL)

STORAGESEVER

2008-08-18

Aug 18, 2008 ... leaves (1000 g) were subjected to steam distillation for approxi- mately 3 h using a ... (86.95%; retention time = 4.63 min), benzene (6.69%; retention time ... were isopropyl toluene and trans-caryophyllene of which the values ...

Effects of Rhus coriaria on nutrient composition, thiobarbituric acid ...

African Journals Online (AJOL)

Dear User!

2015-03-04

Mar 4, 2015 ... substances and colour of thigh meat in heat-stressed broilers ... distribute, transmit and adapt the work, but must recognise the authors and the South ... Heat stress is a major cause of deterioration in performance and even ...

Effects of Rhus coriaria on nutrient composition, thiobarbituric acid ...

African Journals Online (AJOL)

Heat stress negatively affects the meat quality in broiler chickens, as indicated by lipid peroxidation. The aim of this study was to investigate the effects of 0.0, 2.5, 5.0 and 10 g sumac fruit powder/kg of the diet, along with 100 mg α-tocopherol acetate (AT)/kg as antioxidants, on meat characteristics of broilers under heat ...

Loss of residual heat removal system: Diablo Canyon, Unit 2, April 10, 1987

International Nuclear Information System (INIS)

1987-06-01

This report presents the findings of an NRC Augmented Inspection Team (AIT) investigation into the circumstances associated with the loss of residual heat removal (RHR) system capability for a period of approximately one and one-half hours at the Diablo Canyon, Unit 2 reactor facility on April 10, 1987. This event occurred while the Diablo Canyon, Unit 2, a pressurized water reactor, was shutdown with the reactor coolant system (RCS) water level drained to approximately mid-level of the hot leg piping. The reactor containment building equipment hatch was removed at the time of the event, and plant personnel were in the process of removing the primary side manways to gain access into the steam generator channel head areas. Thus, two fission product barriers were breached throughout the event. The RCS temperature increased from approximately 87 0 F to bulk boiling conditions without RCS temperature indication available to the plant operators. The RCS was subsequently pressurized to approximately 7 to 10 psig. The NRC AIT members concluded that the Diablo Canyon, Unit 2 plant was, at the time of the event, in a condition not previously analyzed by the NRC staff. The AIT findings from this event appear significant and generic to other pressurized water reactor facilities licensed by the NRC

Evaluating skin-protective materials against contact irritants and allergens. An in vivo screening human model.

Science.gov (United States)

Zhai, H; Willard, P; Maibach, H I

1998-03-01

2 acute irritants and 1 allergen were selected: sodium lauryl sulfate (SLS) representative of irritant household and occupational contact dermatitis, the combination of ammonium hydroxide (NH4OH) and urea to simulate diaper dermatitis, and Rhus to evaluate the effect of model protective materials. The putative protective materials and vehicle were applied to both ventral forearms of 10 subjects in each group, according to a randomized code. Test materials were spread over a marked 2.0 cm2 area, massaged in, allowed to dry for 30 min, and reapplied with another 30 min drying period. The model irritants and allergen were then applied (0.025 ml) to an Al-test occlusive patch, which in turn was placed for 24 h over each of the 8 designated sites. Inflammation was scored according to a clinical scale 72 h post-application. Paraffin wax plus Acetulan in cetyl alcohol, and beeswax plus Acetulan in cetyl alcohol, markedly (p < 0.001) suppressed SLS irritation. Paraffin wax plus beeswax in cetyl alcohol, and Acetulan in cetyl alcohol reduced NH4OH and urea irritation (p < 0.05), paraffin wax in cetyl alcohol significantly (p < 0.01) decreasing Rhus allergic contact dermatitis. This model, provides an easy approach to screening protectants. Its clinical significance requires comparison with an open rather than an occluded challenge.

Effects of herbivory on the reproductive effort of 4 prairie perennials

Directory of Open Access Journals (Sweden)

Bradley Kate L

2002-02-01

Full Text Available Abstract Background Herbivory can affect every aspect of a plant's life. Damaged individuals may show decreased survivorship and reproductive output. Additionally, specific plant species (legumes and tissues (flowers are often selectively targeted by herbivores, like deer. These types of herbivory influence a plant's growth and abundance. The objective of this study was to identify the effects of leaf and meristem removal (simulated herbivory within an exclosure on fruit and flower production in four species (Rhus glabra, Rosa arkansana, Lathyrus venosus, and Phlox pilosa which are known targets of deer herbivory. Results Lathyrus never flowered or went to seed, so we were unable to detect any treatment effects. Leaf removal did not affect flower number in the other three species. However, Phlox, Rosa, and Rhus all showed significant negative correlations between seed mass and leaf removal. Meristem removal had a more negative effect than leaf removal on flower number in Phlox and on both flower number and seed mass in Rosa. Conclusions Meristem removal caused a greater response than defoliation alone in both Phlox and Rosa, which suggests that meristem loss has a greater effect on reproduction. The combination of leaf and meristem removal as well as recruitment limitation by deer, which selectively browse for these species, is likely to be one factor contributing to their low abundance in prairies.

Ole Rømer-Observatoriet

DEFF Research Database (Denmark)

Buhl, Hans; Knudsen, Ole J.; Nielsen, Axel V.

Siden 1911 har der ligget et astronomisk observatorium i Århus. Ole Rømer-Observatoriet blev efter en turbulent start drevet af kommunen, indtil Aarhus Universitet i 1956 overtog det. Der har fra tid til anden været både kontroverser og trusler om lukning, men arbejdet på observatoriet har også...... fortæller museumsinspektør Hans Buhl og planetarieleder Ole J. Knudsen, begge Steno Museet, de næste 95 år af observatoriets brogede historie....

Magneter der husker

DEFF Research Database (Denmark)

Buhl, Hans

2010-01-01

Steno Museet i Århus er Danmarks Videnskabshistoriske Museum. Derfor spiller naturvidenskabens udvikling en central rolle i museets formidling. Men det ligger os også meget på sinde at vise videnskabens betydning for vores hverdag. Derfor udstiller Steno Museet ikke blot videnskabelige instrument......, altså videnskabsmændenes værktøj. Vi viser også nogle af de teknologier, som videnskaben har ført til, f.eks. telegrafer, telefoner og forskellige former for magnetisk lagring. Udgivelsesdato: Aug. 2010...

Subway Market Research

OpenAIRE

Liutu, Riina

2010-01-01

The main goal of this thesis is to find out whether Danish entrepreneurs can become successful in the Danish market as Subway franchisees. Three specific cities, namely Århus, Horsens and Vejle, are looked at in depth. In the thesis, these three cities will represent the Danish market. An evaluation of the most suitable location for a Subway restaurant is made. To reach the above objective, the Subway franchising concept, the market situation, the customers and the competitive situation will ...

Task Force on Culture and Ethnic Diversity

DEFF Research Database (Denmark)

Singla, Rashmi

differences. Key words: work motivation, (sub) cultural differences, meta-representation. Email: kolman@pef.czu.cz 3.Abstract for presentation in Symposium Case conceptualization, relationship building and intervention challenges with culturally diverse clients among clinical psychologists: a case...... of knowledge originating from different geographical contexts. The initiative taken by the psychology students in Århus University, the specific course dynamic developed and the evaluation is to be delineated in the paper. In addition, both pedagogical psychological aspects and long term consequences...

Flow cytometry approach for studying the interaction between ...

African Journals Online (AJOL)

Flow cytometry approach for studying the interaction between Bacillus mojavensis and Alternaria alternata. Asma Milet, Noreddine Kacem Chaouche, Laid Dehimat, Asma Ait Kaki, Mounira Kara Ali, Philippe Thonart ...

Ülemaaline ilulugejate 15. võistulausumine

Index Scriptorium Estoniae

2008-01-01

Vabariiklikust etlejate konkursist. 4.-6. klasside arvestuses võitis Grand Prix'i Markkus Pulk, laureaatideks tulid Maria Pihlak, Kenneth Norden ja Laura Elisabeth Konsand. Eripreemiad said Laura Oolup, Maria Zaitseva, žürii aitähi said Sander Aavik ja Liisa Lutter. 7.-9. klasside arvestuses võitis Grand Prix' Anna Talvi, laureaatideks tulid Liisa Saaremäel, Karmen Kozma, Riko Osila. Eripreemiad said Indrek Jõe, Eliise Seedre, žürii aitähi sai Kirke Algma. 10.-12. klasside arvestuses võitis Grand Prix' Doris Tääker, laureaatideks tulid Jörgen Liik, Virgo Ernits ja Ilja Massalov. eripreemiad said Marian Heinat ja Kadri Toomsalu. Kuressaare Gümnaasiumi õpilasžürii preemiad läksid Kenneth Nordenile, Riko Osilale ja Doris Tääkerile

Tükiyenin farklı bölgelerinde üretilen değişik un tiplerinin tiamin ve riboflavin miktarları

Directory of Open Access Journals (Sweden)

Raci Ekinci

2002-03-01

Full Text Available Çalışmada, Türkiye'nin 7 ayrı bölgesine ait 19 farklı ilde un üretimi yapan 30 fabrikadan sağlanan (30 adet Tip 550, 30 adet Tip 650 ve 26 adet Tip 850 un örnekleri vitaminlerde tiamin ve riboflavin miktarı açısından incelenmiştir. Un tipleri açısından ortalama tiamin ve riboflavin değerleri arasında önemli farklılıklar olduğu, ancak farklı fabrikalara ait unların tiamin ve riboflavin miktarı arasındaki farklılıklar istatistiksel olarak önemli bulunmamıştır (P

Selenium Supplementation Significantly Reduces Thyroid Autoantibody Levels in Patients with Chronic Autoimmune Thyroiditis

DEFF Research Database (Denmark)

Wichman, Johanna Eva Märta; Winther, Kristian Hillert; Bonnema, Steen Joop

2016-01-01

BACKGROUND: Selenium supplementation may decrease circulating thyroid autoantibodies in patients with chronic autoimmune thyroiditis (AIT), but the available trials are heterogenous. This study expands and critically reappraises the knowledge on this topic. METHODS: A literature search identified...... 3366 records. Controlled trials in adults (≥18 years of age) with AIT, comparing selenium with or without levothyroxine (LT4), versus placebo and/or LT4, were eligible. Assessed outcomes were serum thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) autoantibody levels, and immunomodulatory effects...... and LT4-untreated. Heterogeneity was estimated using I(2), and quality of evidence was assessed per outcome, using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines. RESULTS: In LT4-treated populations, the selenium group had significantly lower TPOAb levels after...

Advanced Interval Type-2 Fuzzy Sliding Mode Control for Robot Manipulator

Directory of Open Access Journals (Sweden)

Ji-Hwan Hwang

2017-01-01

Full Text Available In this paper, advanced interval type-2 fuzzy sliding mode control (AIT2FSMC for robot manipulator is proposed. The proposed AIT2FSMC is a combination of interval type-2 fuzzy system and sliding mode control. For resembling a feedback linearization (FL control law, interval type-2 fuzzy system is designed. For compensating the approximation error between the FL control law and interval type-2 fuzzy system, sliding mode controller is designed, respectively. The tuning algorithms are derived in the sense of Lyapunov stability theorem. Two-link rigid robot manipulator with nonlinearity is used to test and the simulation results are presented to show the effectiveness of the proposed method that can control unknown system well.

Transporting Patients with Lethal Contagious Infections

National Research Council Canada - National Science Library

Swartz, Colleen

2002-01-01

.... The AIT is a unique military medical team capable of worldwide air evacuation and management of a limited number of patients who are potentially exposed to known and unknown lethal communicable...

”Pigen der ikke ville dø” - starten på en krise

OpenAIRE

Bonde, Anders; Nannberg, Niklas Schlippe

2013-01-01

The project aims to determine how Århus Universitetshospital and the consultant have handled the crisis related to the documentary called ”Pigen der ikke ville dø” and to evaluate eventual improvements. A focus group, a press release and several articles are the empirical data, which we analyse by the means of W. Timothy Coombs and William L. Benoit’s theories of crisis communication. The former deals with the strategic aspect of the field and the latter with the rhetorical. Finally we compar...

Unges udeliv - i multietniske boligområder

DEFF Research Database (Denmark)

Børresen, Sølvi Karin; Schytte, Benny

Rapporten omhandler de unges udeliv i multietniske boligområder, hvor opmærksomheden er rettet mod hverdagslivet og de unges adfærd og anvendelse af udemiljøet i boligområderne. Endvidere gives der eksempler på konkrete tiltag og problemløsninger i relation til de unges anvendelse af udemiljøet. ....... Undersøgelsen er fortaget i de tre boligområder: AKB Lundtoftegade på Ydre Nørrebro i København, Vollsmose i Odense og Gellerup ved Århus....

Selenium Supplementation does not Decrease Thyroid Peroxidase Antibody Concentration in Children and Adolescents with Autoimmune Thyroiditis

Directory of Open Access Journals (Sweden)

W. Bonfig

2010-01-01

Full Text Available In adults, selenium supplementation decreases thyroid peroxidase antibody (TPO Ab concentrations in patients with autoimmune thyroiditis (AIT. Our aim in this study was to investigate if selenium supplementation decreased TPO Ab and thyroglobulin antibody (Tg Ab concentrations in children with AIT. Forty-nine patients (33 females with newly diagnosed AIT and hypothyroidism were randomized to daily oral therapy with levothyroxine alone (group A, n = 18, levothyroxine plus 100 µg sodium-selenite (group B, n = 13, or levothyroxine plus 200 µg sodium-selenite (group C, n = 18. Mean age at diagnosis was 12.2 ± 2.2 years. All 49 patients needed a mean levothyroxine dose of 1.6 ± 0.5 µg/kg body weight to lower TSH to the treatment goal of 1–2 µU/ml, with no significant difference between groups. At study entry and after 12 months, TPO Ab concentrations were comparable in all three groups. Tg Ab concentrations decreased significantly after 12 months in group A and group C (p = 0.03 and p = 0.01, but not in group B (p = 0.06. It is our conclusion that selenium supplementation with sodium-selenite does not decrease TPO Ab concentrations in children and adolescents, neither given in the reduced dose of 100 µg daily nor given in the “adult” supplementation dose of 200 µg daily.

Antimicrobial edible coatings and films from micro-emulsions and their food applications.

Science.gov (United States)

Guo, Mingming; Yadav, Madhav P; Jin, Tony Z

2017-12-18

This study focused on the use of antimicrobial edible coatings and films from micro-emulsions to reduce populations of foodborne pathogens in foods. Corn-Bio-fiber gum (C-BFG) was used as an emulsifier with chitosan. Allyl isothiocyanate (AIT) and lauric arginate ester (LAE) served as antimicrobials. Micro-emulsions were obtained from a solution consisting of 1% chitosan, 0.5% C-BFG, and 1-4% AIT or LAE which was subject to high pressure homogenization (HPH) processing at 138MPa for 3cycles. Coatings and films produced from the micro-emulsions had micro-pores with sizes ranging from 100 to 300nm and micro-channels that hold antimicrobials effectively and facilitate the release of antimicrobials from the center to the surface of the films or coatings, thus enhancing their antimicrobial efficacy. The coatings and films with 1% AIT reduced populations of Listeria innocua by over 5, 2, and 3 log CFU in culture medium (Tryptic soy broth, TSB), ready-to-eat meat, and strawberries, respectively. The coatings and films with 1% LAE reduced populations of Escherichia coli O157:H7 and Salmonella spp. by over 5 and 2 log CFU in TSB and strawberries, respectively. This study provides an innovative approach for the development of effective antimicrobial materials to reduce food borne pathogenic contaminants on ready-to-eat meat, strawberries, or other food. Published by Elsevier B.V.

First report of Lecanodiaspis dendrobii Douglas, 1892 (Hemiptera: Lecanodiaspididae and the associated parasitoid Cephaleta sp. (Hymenoptera: Pteromalidae in Brazil

Directory of Open Access Journals (Sweden)

A. L. Marsaro Júnior

Full Text Available Abstract Lecanodiaspis dendrobii Douglas, 1892 (Hemiptera: Coccoidea: Lecanodiaspididae and the associated parasitoid Cephaleta sp. (Hymenoptera: Pteromalidae are reported for the first time in Brazil. Specimens of this scale insect were collected on branches and stems of Acacia mangium Willd., Leucaena leucocephala (Lam. de Wit (Fabaceae, Morus nigra L. (Moraceae, Citrus reticulata Blanco (Rutaceae, Tectona grandis L. f. (Verbenaceae, Anacardium occidentale (Anacardiaceae, Annona squamosa L. and Xylopia aromatica (Lam. Mart. (Annonaceae, in three municipalities of the Roraima state. All plants here mentioned are recorded for the first time as a host for L. dendrobii. Morphological characters of L. dendrobii and symptoms presented by the host plants infested by this pest are included in this work.

First report of Lecanodiaspis dendrobii Douglas, 1892 (Hemiptera: Lecanodiaspididae) and the associated parasitoid Cephaleta sp. (Hymenoptera: Pteromalidae) in Brazil.

Science.gov (United States)

Marsaro Júnior, A L; Peronti, A L B G; Costa, V A; Morais, E G F; Pereira, P R V S

2016-02-01

Lecanodiaspis dendrobii Douglas, 1892 (Hemiptera: Coccoidea: Lecanodiaspididae) and the associated parasitoid Cephaleta sp. (Hymenoptera: Pteromalidae) are reported for the first time in Brazil. Specimens of this scale insect were collected on branches and stems of Acacia mangium Willd., Leucaena leucocephala (Lam.) de Wit (Fabaceae), Morus nigra L. (Moraceae), Citrus reticulata Blanco (Rutaceae), Tectona grandis L. f. (Verbenaceae), Anacardium occidentale (Anacardiaceae), Annona squamosa L. and Xylopia aromatica (Lam.) Mart. (Annonaceae), in three municipalities of the Roraima state. All plants here mentioned are recorded for the first time as a host for L. dendrobii. Morphological characters of L. dendrobii and symptoms presented by the host plants infested by this pest are included in this work.

Effect of Different Carbon Substrates on Nitrate Stable Isotope Fractionation During Microbial Denitrification

DEFF Research Database (Denmark)

Wunderlich, Anja; Meckenstock, Rainer; Einsiedl, Florian

2012-01-01

-labeled water and 18O-labeled nitrite were added to the microcosm experiments to study the effect of putative backward reactions of nitrite to nitrate on the stable isotope fractionation. We found no evidence for a reverse reaction. Significant variations of the stable isotope enrichment factor ε were observed......In batch experiments, we studied the isotope fractionation in N and O of dissolved nitrate during dentrification. Denitrifying strains Thauera aromatica and “Aromatoleum aromaticum strain EbN1” were grown under strictly anaerobic conditions with acetate, benzoate, and toluene as carbon sources. 18O...... of nitrate transport across the cell wall compared to the kinetics of the intracellular nitrate reduction step of microbial denitrification....

Larvicidal activity of some Cerrado plant extracts against Aedes aegypti.

Science.gov (United States)

Rodrigues, A M S; De Paula, J E; Degallier, N; Molez, J E; Espindola, L S

2006-06-01

One hundred ninety hexanic and ethanolic extract from 27 plant species from the Cerrado biome of Brazil were tested for larvicidal activity against 3rd-stage Aedes aegypti larvae at 500 microg/ml. Fourteen extracts from 7 species showed activity (>65% mortality) against the larvae. Of these Dugeutia furfuracea, Piptocarpha rotundifolia, Casearia sylvestris var. lingua, Serjania lethalis, and Xylopia aromatica were active at 56.6, 162.31, 232.4, 285.76, and 384.37 microg/ml, respectively. Annona crassiflora and Cybistax antisyphilitica showed activity at 23.06 and 27.61 microg/ml. The larvicidal properties of these species are described for the first time, and may prove to be promising in active chemical compound isolation.

Vegetation description of the Doornhoek section of the Mountain Zebra National Park (MZNP, South Africa

Directory of Open Access Journals (Sweden)

Hugo Bezuidenhout

2008-12-01

Full Text Available The Mountain Zebra National Park (MZNP has been extended over the last couple of years. One of the newly procured areas is the Doornhoek section, which had been adjacent to the park. To develop scientifically sound management programmes for conservation areas, it is essential that an inventory of their natural resources be undertaken. The aim of this study was to classify, describe and map the vegetation of the Doornhoek section of the park. The floristic data were analysed in accordance with the Braun-Blanquet procedures using the BBPC suite. The data analysis resulted in the identification of eight communities, which can be grouped into seven major community types (Rhus lucida–Buddleja glomerata Shrubland, Rhigozum obovatum–Rhus longispina Shrubland, Helichrysum dregeanum–Aristida diffusa Grassland, Pentzia globosa–Enneapogon scoparius Grassland, Aristida adscensionus–Pentzia globosa Grassland, Cadaba aphylla–Acacia karroo Woodland and Lycium oxycarpum–Acacia karroo Woodland. Four of these communities occur on the higher-lying plateau, mid-slope and crest areas, while the other four communities are located on the lower-lying mid-plateau and foot slope, along drainage lines and in valley-bottom areas. The description of the plant communities, together with the vegetation map, can serve as a basis for formulating a management programme for the larger park. Although sections of Doornhoek have been overgrazed and degraded in the past, its recent addition to the MZNP contributes to the available habitat preferred by large herbivores, such as valley bottoms, foot-slopes and plateaux.

Antifungal Activity of Volatile Oil of Mustard (VOM)

National Research Council Canada - National Science Library

Sikes, A; Yang, T; Richardson, M; Ehioba, R

2005-01-01

.... The active volatile antimicrobial factor in VOM is allyl isothiocyanate (AIT). To evaluate the efficacy of VOM as a fungistatic agent, military-type sandwiches and commercial cheddar cheese samples were inoculated with several mold isolates...

The Importance Therapeutic of Products Extracted from the Fir Tree of Numidia (Abies numidica) and Research for an Antibacterial Activity

OpenAIRE

YASMİNA, Tlili AitKaki; BENNADJA, Salima; ABDELGHANİ, Djahoudi

2014-01-01

Yasmina TLILI AIT KAKI, Salima BENNADJA, Djahoudi ABDELGHANI Laboratoire de botanique médicale, Département de pharmacie, Faculté de médecine, Université Badji Mokhtar Annaba, 23000 Algérie *Corresponding Author:

Clinical studies on thyroid diseases

NARCIS (Netherlands)

Eskes, S.A.

2014-01-01

This thesis focuses on some aspects of thyroid disease: prevention of autoimmune thyroid disease (AITD), diagnosis of related conditions as autoimmune hypophysitis in autoimmune hypothyroidism (Hashimoto’s disease), and treatment of amiodarone-induced thyrotoxicosis (AIT).

Probability of Boulders

DEFF Research Database (Denmark)

Ditlevsen, Ove Dalager

1997-01-01

To collect background information for formulating a description of the expected soil properties along the tunnel line, in 1987 Storebælt initiated a statistical investigation of the occurrence and size of boulders in the Great Belt area. The data for the boulder size distribution were obtained....... The data collection part of the investigation was made on the basis of geological expert advice (Gunnar Larsen, Århus) by the Danish Geotechnical Institute (DGI).The statistical data analysis combined with stochastic modeling based on geometry and sound wave diffraction theory gave a point estimate...

Calcifications valvulaires chez l'hémodialysé au Maroc | Faqih | Pan ...

African Journals Online (AJOL)

Calcifications valvulaires chez l'hémodialysé au Maroc. Samia Ait Faqih, Béfa Noto-Kadou-Kaza, Lalla Meryam Abouamrane, Naoufal Mtiou, Selma El Khaya, Mohamed Zamd, Ghislaine Medkouri, Mohamed Gharbi Bengahanem, Benyounes Ramdani ...

78 FR 25734 - Notice of Petition for Waiver of Hussmann From the Department of Energy Commercial Refrigerator...

Science.gov (United States)

2013-05-02

...--18[deg]F range (The amount and method of merchandising the food product varies which results in a... amount and method of merchandising the food product varies which results in a wide range of AIT). This...

Improving the security of the Hwang-Su protocol for mobile networks

African Journals Online (AJOL)

user

Improving the security of the Hwang-Su protocol for mobile networks. Miloud Ait ... But, it is threatened by weak ... Wireless networks (IEEE standard 802.11 1996, Gast 2005) have allowed computer systems to exchange data without cable.

237. Malformación hamartomatosa de la aurícula izquierda como causa infrecuente de ataque isquémico transitorio de repetición

Directory of Open Access Journals (Sweden)

O. Leal

2012-04-01

Conclusiones: Ante la presencia de AIT, en primer lugar debemos considerar el origen cardioembólico, excluidos éstos, la patología tumoral aunque infrecuente debe tenerse en cuenta, y su tratamiento generalmente es quirúrgico.

Allergen Immunotherapy (AIT): a prototype of Precision Medicine

NARCIS (Netherlands)

Canonica, G. W.; Bachert, C.; Hellings, P.; Ryan, D.; Valovirta, E.; Wickman, M.; de Beaumont, O.; Bousquet, J.

2015-01-01

Precision medicine is a medical model aiming to deliver customised healthcare - with medical decisions, practices, and/or products tailored to the individual patient informed but not directed by guidelines. Allergen immunotherapy has unique immunological rationale, since the approach is tailored to

Differential Canalograms Detect Outflow Changes from Trabecular Micro-Bypass Stents and Ab Interno Trabeculectomy.

Science.gov (United States)

Parikh, Hardik A; Loewen, Ralitsa T; Roy, Pritha; Schuman, Joel S; Lathrop, Kira L; Loewen, Nils A

2016-11-04

Recently introduced microincisional glaucoma surgeries that enhance conventional outflow offer a favorable risk profile over traditional surgeries, but can be unpredictable. Two paramount challenges are the lack of an adequate training model for angle surgeries and the absence of an intraoperative quantification of surgical success. To address both, we developed an ex vivo training system and a differential, quantitative canalography method that uses slope-adjusted fluorescence intensities of two different chromophores to avoid quenching. We assessed outflow enhancement by trabecular micro-bypass (TMB) implantation or by ab interno trabeculectomy (AIT). In this porcine model, TMB resulted in an insignificant (p > 0.05) outflow increase of 13 ± 5%, 14 ± 8%, 9 ± 3%, and 24 ± 9% in the inferonasal, superonasal, superotemporal, and inferotemporal quadrant, respectively. AIT caused a 100 ± 50% (p = 0.002), 75 ± 28% (p = 0.002), 19 ± 8%, and 40 ± 21% increase in those quadrants. The direct gonioscopy and tactile feedback provided a surgical experience that was very similar to that in human patients. Despite the more narrow and discontinuous circumferential drainage elements in the pig with potential for underperformance or partial stent obstruction, unequivocal patterns of focal outflow enhancement by TMB were seen in this training model. AIT achieved extensive access to outflow pathways beyond the surgical site itself.

Yeast Interacting Proteins Database: YJL137C, YLR258W [Yeast Interacting Proteins Database

Lifescience Database Archive (English)

Full Text Available ait as prey (1) YLR258W GSY2 Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, ...ssion induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulat

Yeast Interacting Proteins Database: YNL189W, YGL175C [Yeast Interacting Proteins Database

Lifescience Database Archive (English)

Full Text Available ait as prey (0) YGL175C SAE2 Endonuclease that processes hairpin DNA structures w... (0) Prey ORF YGL175C Prey gene name SAE2 Prey description Endonuclease that processes hairpin DNA structures

Allergen immunotherapy for allergic rhinoconjunctivitis : A systematic overview of systematic reviews

NARCIS (Netherlands)

Nurmatov, Ulugbek; Dhami, Sangeeta; Arasi, Stefania; Roberts, Graham; Pfaar, Oliver; Muraro, Antonella; Ansotegui, Ignacio J; Calderon, Moises; Cingi, Cemal; Durham, Stephen; van Wijk, Roy Gerth; Halken, Susanne; Hamelmann, Eckard; Hellings, Peter W; Jacobsen, Lars; Knol, Edward; Larenas-Linnemann, Desiree; Lin, Sandra Y; Maggina, Vivian; Oude Elberink, J Hanneke N G; Pajno, Giovanni Battista; Panwankar, Ruby; Pastorello, Elideanna; Pitsios, Constantinos; Rotiroti, Giuseppina; Timmermans, Frans; Tsilochristou, Olympia; Varga, Eva-Maria; Wilkinson, Jamie; Williams, Andrew; Worm, Margitta; Zhang, Luo; Sheikh, Aziz

2017-01-01

Background: The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines on Allergen Immunotherapy (AIT) for Allergic Rhinoconjunctivitis (ARC). To inform the development of recommendations, we sought to critically assess the systematic review evidence on the

Immunogenetics of type 1 diabetes mellitus

African Journals Online (AJOL)

EL-HAKIM

to other autoimmune diseases, the etiology of T1D remains obscure but ..... T1D, type 1 diabetes; AIT, autoimmune thyroiditis; CD, celiac disease; AD, Addison's disease. Table 5. .... (GAD65Ab) in prediabetic adults developing diabetes.

ÇİN’E AİT İMGE VE MOTİFLERİN ŞEHNÂME’YE GÖRE TAHLİLİ

OpenAIRE

KOÇ KONUKSEVER, SERPİL

2016-01-01

Firdevsî’nin kaleme aldığı “Şehnâme” İran’ın zengin ve köklü millî değerlerinin bir arada toplandığı destansı bir eserdir. Uzun asırlardan günümüze ulaşan bu eser, hâlâ değerini koruyan dünyanın seçkin epopeleri arasındadır. İranlıların uzun asırlar münasebet içerisinde oldukları Türk, Yunan, Arap ve Çin gibi milletlere ait izleri taşımaktadır. Yazımızda, Şehnâme’de yer alan Çin’e ait imge ve motiflerin tahliline yönelik kavramlar ele alınacaktır...

Allergen immunotherapy for the prevention of allergy

DEFF Research Database (Denmark)

Kristiansen, Maria; Dhami, Sangeeta; Netuveli, Gopal

2017-01-01

BACKGROUND: There is a need to establish the effectiveness, cost-effectiveness, and safety of allergen immunotherapy (AIT) for the prevention of allergic disease. METHODS: Two reviewers independently screened nine international biomedical databases. Studies were quantitatively synthesized using...... was found in relation to its longer-term effects for this outcome. There was, however, a reduction in the short-term risk of those with allergic rhinitis developing asthma (RR = 0.40; 95% CI: 0.30-0.54), with this finding being robust to a pre-specified sensitivity analysis. We found inconclusive evidence...... random-effects meta-analyses. RESULTS: A total of 32 studies satisfied the inclusion criteria. Overall, meta-analysis found no conclusive evidence that AIT reduced the risk of developing a first allergic disease over the short term (RR = 0.30; 95% CI: 0.04-2.09) and no randomized controlled evidence...

Analysis of allergen immunotherapy studies shows increased clinical efficacy in highly symptomatic patients

DEFF Research Database (Denmark)

Howarth, P; Malling, Hans-Jørgen; Molimard, M

2011-01-01

them. Thus, clinical studies of AIT can neither establish baseline symptom levels nor limit the enrolment of patients to those with the most severe symptoms. Allergen immunotherapy treatment effects are therefore diluted by patients with low symptoms for a particular pollen season. The objective...... tertiles). The difference observed in the average score in each tertile in active vs placebo-treated patients was assessed. This allowed an estimation of the efficacy that could be achieved in patients from sites where symptoms were high during the pollen season. Results:  An increased treatment effect...... of this analysis was to assess the effect possible to achieve with AIT in the groups of patients presenting the most severe allergic symptoms. Methods:  Study centres were grouped into tertiles categorized according to symptom severity scores observed in the placebo patients in each centre (low, middle and high...

[Autoimmune diseases of the thyroid gland].

Science.gov (United States)

Allelein, S; Feldkamp, J; Schott, M

2017-01-01

Autoimmune diseases of the thyroid gland are considered to be the most frequent cause of thyroid gland disorders. Autoimmune thyroid diseases consist of two subgroups: autoimmune thyroiditis (AIT) and Graves' disease. The AIT is the most common human autoimmune disease. Infiltration of the thyroid gland with cytotoxic T‑cells can lead to an initial thyrotoxicosis und during the course to hypothyroidism due to destruction of the thyroid gland. Substitution with Levothyroxine is indicated for manifest hypothyroidism and subclinical hypothyroidism with increased thyroid antibodies with the intention of normalizing the serum thyroid stimulating hormone (TSH). Graves' disease is characterized by the appearance of stimulating TSH receptor antibodies leading to hyperthyroidism. Endocrine ophthalmopathy may also occur. Ablative therapy with radioiodine therapy or thyroidectomy is administered to patients with Graves' disease without remission after at least 1 year of antithyroid drug therapy.

Air-Based Remediation Workshop - Section 8 Air-Based Remediation Technology Selection Logic

Science.gov (United States)

Pursuant to the EPA-AIT Implementing Arrangement 7 for Technical Environmental Collaboration, Activity 11 "Remediation of Contaminated Sites," the USEPA Office of International Affairs Organized a Forced Air Remediation Workshop in Taipei to deliver expert training to the Environ...

Maakeskond mõisa kõrval. Taluehitiste klassikalised vormid / Juta Saron

Index Scriptorium Estoniae

Saron, Juta

2005-01-01

Rehielamu, selle Põha-Eesti ja Lõuna-Eesti variant. Rehetuba, rehealune, taluelamu dekoor ja sisustus. Rehemaja välisilme ja "kuldlõige". Setu, rannarootsi ja Kuusalu neemedel esinevad elamutüübid. Saun, suvekoda, ait, õuekujundus. Bibliofraafia lk. 454-455

The Effect of Storage on the Efficacy of Eugenia Aromatica (Baill.) in ...

African Journals Online (AJOL)

MICHAEL

fumigant toxicity test, first use of the differently aged powders prevented ... In a consecutive reuse of powders, adults emerged from fumigated eggs but the ... These study investigated aspects ... material per 20 g of seed in separate plastic Petri.

Seasonal dynamics of water and nutrient fluxes is an agricultural peatland

Science.gov (United States)

The American cranberry (Vaccinium macrocarpon Ait.) is an important part of the cultural heritage and economy of southeastern Massachusetts, yet water quality concerns, wetland protection laws, and increased competition challenge its production. Despite their regional importance, few data on nitroge...

Future developments and applications of nitrogen-bearing steels ...

Indian Academy of Sciences (India)

M. Senthilkumar (Newgen Imaging) 1461 1996 Oct 15 13:05:22

society in the field of materials and some recalling of basic properties and principles ... Environment-friendly technologies (safety in oil pipelines, oil exploration . ..... Vogt J-B, Ait Saadi B, Foct J 1999 Analysis of the fatigue structures in a duplex ...

Improving the security of the Hwang-Su protocol for mobile networks

African Journals Online (AJOL)

user

Improving the security of the Hwang-Su protocol for mobile networks. Miloud Ait Hemad, My ... Furthermore, the wireless data channel is low data rate. These restrictions have an ..... Research in Security and Privacy. Wu T. Y. and Tsen Y. M., ...

Health economic analysis of allergen immunotherapy for the management of allergic rhinitis, asthma, food allergy and venom allergy: A systematic overview

NARCIS (Netherlands)

Asaria, M.; Dhami, S.; van Ree, R.; Gerth van Wijk, R.; Muraro, A.; Roberts, G.; Sheikh, A.

2018-01-01

Background: The European Academy of Allergy and Clinical Immunology (EAACI) is developing guidelines for allergen immunotherapy (AIT) for the management of allergic rhinitis, allergic asthma, IgE-mediated food allergy and venom allergy. To inform the development of clinical recommendations, we

31M10 Functional Basic Skills Education Package.

Science.gov (United States)

1982-09-01

Interviewer’s ID: _______________ Date: __________ CRITICAL INCIDENT INTERVIEW FOR STUDENTS * -(Good Performance) Ii Introductory Statement: The Army... CRITICAL INCIDENT INTERVIEW FOR STUDENTS (Poor Performance) Introductory Statement: The Army is interested in improving Army life while you’re in AIT. You

Sebestén y zumaque, dos frutos importados de Oriente durante la Edad Media

Directory of Open Access Journals (Sweden)

García Sánchez, Expiración

2001-12-01

Full Text Available This paper joins a number of historical pieces of information concerning two species of Asiatic origin, sebesten and sumac, whose fruits are mentioned among the goods brought to Barcelona from Syria during the fourteenth and fifteenth centuries. In the case of the sebesten, we are in front of a tree native to India (Cordia myxa L., whose edible fruits were employed to make a birdlime employed to catch birds. As for the sumach (Rhus coriaria L., the fruits of this shrub were used traditionally to tan the leather. The information here offered has been taken from Grecolatin, Andalusian and later authors.

Se recogen en este trabajo una serie de datos históricos relativos a dos especies de origen asiático, el sebestén y el zumaque, cuyos frutos aparecen citados entre las mercaderías llegadas a Barcelona desde Siria a lo largo de los siglos XIV y XV. En el caso del sebestén, se trata de un árbol originario de la India (Cordia myxa L., cuyos frutos comestibles se utilizaban además para fabricar una especie de liga para cazar pájaros. En cuanto al zumaque (Rhus coriaria L., los frutos de este arbusto se utilizaban tradicionalmente para los curtidos del cuero. De ambas especies se ofrece toda la información histórica que ha sido posible reunir, tomada de los autores grecolatinos, andalusíes y otros posteriores.

: tous les projets | Page 183 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

De son indépendance acquise en 1960 jusqu'en 1999, la Côte d'Ivoire était l'un des ... Bien que le monde arabe ait connu un progrès économique considérable, ... ASPECTS, INTERNATIONAL RELATIONS, INSTITUTIONAL FRAMEWORK.

The American cranberry mitochondrial genome reveals the presence of selenocysteine (tRNA-Sec and SECIS) insertion machinery in land plants

Science.gov (United States)

The American cranberry (Vaccinium macrocarpon Ait.) mitochondrial genome was assembled and reconstructed from whole genome 454 Roche GS-FLX and Illumina shotgun sequences. Compared with other Asterids, the reconstruction of the genome revealed an average size mitochondrion (459,678 nt) with comparat...

Filosoofiaõhtu Kloostri Aidas

Index Scriptorium Estoniae

2012-01-01

Restoranis Kloostri Ait toimub üritus, kus prantsuse filosoofi Jacques Derrida raamatust "Surma and" räägivad raamatu tõlkija Mart Kangur ja kirjandusteadlane Hasso Krull. Üritus toimub koostöös raamatu väljaandja, Tallinna Ülikooli Kirjastusega

77 FR 16846 - Published Privacy Impact Assessments on the Web

Science.gov (United States)

2012-03-22

... for personal identification. The AIT does not have the capability to store, transmit, or print these... administrative laws. ICE agents, criminal research specialists, and intelligence analysts use FALCON-SA to conduct research that support the production of law enforcement intelligence products, provide lead...

Fødevareindustrien får sin egen MBA

DEFF Research Database (Denmark)

Stacey, Julia

2004-01-01

To internationale universiteter? Handelshøjskolen i Århus og Wageningen Business School udbyder til årsskiftet en unik international MBA, konkret målrettet fødevareindustrien. 'International MBA for the Food Business' skal sætte gang i kompetenceudviklingen i internationale fødevarevirksomheder og...... engelsk. Deltagerne i uddannelsen forventes at være fast tilknyttet en virksomhed under uddannelsesforløbet, idet en væsentlig del af uddannelsen er løsning af konkrete opgaver i egen virksomhed. Deltagerne skal i alt løse fire opgaver i egen virksomhed. Der igangsættes herved en udviklingsproces i...

Test of the hypothesis; a lymphoma stem cells exist which is capable of self-renewal

DEFF Research Database (Denmark)

Kjeldsen, Malene Krag

  Test of the hypothesis; a lymphoma stem cell exist which is capable of self-renewal   Malene Krag Pedersen, Karen Dybkaer, Hans E. Johnsen   The Research Laboratory, Department of Haematology, Aalborg Hospital, Århus University   Failure of current therapeutics in the treatment of diffuse large B...... and sustaining cells(1-3). My project is based on studies of stem and early progenitor cells in lymphoid cell lines from patients with advanced DLBCL. The cell lines are world wide recognised and generously provided by Dr. Hans Messner and colleagues.   Hypothesis and aims: A lymphoma stem and progenitor cell...

Experimental Studies of CO2 Capturing from the Flue Gases

Directory of Open Access Journals (Sweden)

Ehsan Rahmandoost

2014-10-01

Full Text Available CO2 emissions from combustion flue gases have turned into a major factor in global warming. Post-combustion carbon capture (PCC from industrial utility flue gases by reactive absorption can substantially reduce the emissions of the greenhouse gas CO2. To test a new solvent (AIT600 for this purpose, a small pilot plant was used. This paper presents the results of studies on chemical methods of absorbing CO2 from flue gases with the new solvent, and evaluates the effects of operating conditions on CO2 absorption efficiency. CO2 removal rate of the AIT600 solvent was higher in comparison to the conventional monoethanolamine (MEA solvent. The optimized temperature of the absorber column was 60 °C for CO2 absorption in this pilot plant. The overall absorption rate (Φ and the volumetric overall mass transfer coefficient (KGaV were also investigated.

[Insect venom allergies : Update 2016 for otorhinolaryngologists].

Science.gov (United States)

Klimek, L; Dippold, N; Sperl, A

2016-12-01

Due to the increasing incidence of hymenoptera venom allergies and the potentially life-threatening reactions, it is important for otolaryngologists working in allergology to have an understanding of modern diagnostic and treatment standards for this allergic disease. Molecular diagnosis with recombinant single allergens from bee and wasp venom components improves the diagnostics of insect venom allergies, particularly in patients with double-positive extract-based test results. Detection of specific sensitizations to bee or wasp venom enables double sensitizations to be better distinguished from cross-reactivity. Based on patient history and test results, the patient is initially advised on avoidance strategies and prescribed an emergency medication kit. Then, the indication for allergen-specific immunotherapy (AIT) is evaluated. The dose-increase phase can be performed using conventional, cluster, rush, or ultra-rush schedules, whereby rapid desensitization (rush AIT) performed in the clinic seems to be particularly effective as initial treatment.

A randomised trial comparing the effect of exercise training and weight loss on microvascular function in coronary artery disease

DEFF Research Database (Denmark)

Olsen, Rasmus Huan; Pedersen, Lene Rørholm; Jürs, Anders

2015-01-01

BACKGROUND: Coronary microvascular function is associated with outcome and is reduced in coronary artery disease (CAD) and obesity. We compared the effect of aerobic interval training (AIT) and weight loss on coronary flow reserve (CFR) and peripheral vascular function in revascularised obese CAD...... patients. METHODS AND RESULTS: Seventy non-diabetic patients (BMI 28-40 kg × m(-2), age 45-75 years) were randomised to 12 weeks' AIT (three weekly sessions lasting 38 min with ≈ 16 min at 85-90% of VO2peak) or low energy diet (LED, 800-1000 kcal/day). Per protocol adherence was defined by training......-attendance ≥ 60% and weight loss ≥ 5%, respectively. CFR was assessed by Doppler echocardiography of the LAD. Peripheral vascular function was assessed by arterial tonometry as reactive hyperaemia index (RHI) and augmentation index. Most participants had impaired CFR with a mean CFR of 2.38 (SD 0.59). Twenty...

Diagnóstico diferencial de trombose aortoilíaca e mieloencefalite protozoária equina: relato de caso Differential diagnosis between aorto-iliac thrombosis and equine protozoal myeloencephalitis: case report

Directory of Open Access Journals (Sweden)

P.B. Escodro

2010-10-01

Full Text Available Relata-se o caso de uma égua de atividade de polo, que apresentou inicialmente claudicação leve no membro posterior esquerdo, a qual evoluiu para ataxia e atrofia da musculatura glútea do lado esquerdo, com diagnóstico de trombose aortoilíaca (TAI. A paciente foi tratada com suspeita de mieloencefalite protozoária equina, devido à semelhança dos sinais clínicos com essa doença, porém o líquido cefalorraquidiano apresentou-se negativo para anticorpos anti-Sarcocystis neurona. A palpação transretal indicou uma massa na bifurcação aortoilíaca esquerda. Na avaliação ultrassonográfica, visualizou-se imagem hiperecoica aderida ao endotélio vascular, sugerindo TAI atingindo a estenose de 70% da luz arterial.The case of a mare used for polo is reported. The animal showed clinical signs of soft lameness of the hindlimb, evolving to ataxia and gluteal muscle atrophy, with aorto-iliac thrombosis (AIT. The patient was treated with the suspect of equine protozoal myeloencephalitis (EPM, due to the resemblance of clinical signs. Cerebrospinal fluid analysis was negative for antibodies against Sarcocystis neurona. The transrectal examination indicated a mass in the left aorto-iliac bifurcation. In the ultrasonographic evaluation, a hyperechoic image adhered to the vascular endothelium was observed, suggesting (AIT, occupying 70% of arterial lumen. The present article has the objective of pointing out the importance of the differential diagnosis between AIT and EPM in horses with ataxia in hindlimbs and muscular atrophy.

Thyrotropin Receptor Autoantibodies in differential diagnosis of hyperthyroidism in children

Directory of Open Access Journals (Sweden)

A V Kiyaev

2006-03-01

Full Text Available There was investigation carried out in group of 54 children (42 females and 12 males aged between 10.3 and 17.2 years (median - 13. years for the purpose of the estimation of the clinical significance determination of the general autoantibodies to the TSH recepetor (TBII in differential diagnostics hyperthyroidism. In 45 from 54 cases (83.3 % there was Graves’ disease (GD diagnosis set, while high level of TBII was detected amongst 44 from those children (97.8%. Amongst patients with subacute thyroiditis and uninodal toxic goiter together with 7 children, initially estimated by us as “AIT, hyperthyroidism” the values TBII were in limit of reference interval. But for all of that unexpectedly there was detected normal level of Ab-TPO amongst all patients in this group, and - normal echogenic in 6 from 7 cases. From the one hand, high level of Ab-TG and heterogeneous structure may be estimated as particular qualities of hyperthyroidism clinical course during AIT by amongst children. However, absence of the row of diagnostic signs with long-lasting euthyroid condition do not allow us to estimate that cases as hyperthyroidism phase of AIT. From the other hand, we can suppose that we observe the diagnostic of natural clinical course of GD cases in phase of immunological remission. The detection of normal level of TBII in absence of typical clinical signs of GD amongst children with manifestation of hyperthyroidism let us retreat from active therapeutic intervention and choose the method of dynamic observation.

Inactivation of Salmonella in tomato stem scars by organic acid wash and chitosan-allyl isothiocyanate coating

Science.gov (United States)

The objective of this study was to evaluate inactivation of inoculated Salmonella enterica on tomato stem scars exploiting integrated treatment of organic acid wash (AW) followed by chitosan-allyl isothiocyanate (CT-AIT) coating. The treatment effect on microbial loads and fruit quality during 21 d...

Automated cycled sprinkler irrigation for spring frost protection of cranberries

Science.gov (United States)

Sprinkler irrigation is essential for preventing spring frost bud damage in cranberry (Vaccinium macrocarpon Ait). Risk-averse growers have been reluctant to adopt the intermittent cycling of irrigation pumps as a standard management practice. In the spring of 2013 and 2014, an experiment was conduc...

Jobs at the Borders: What policies can promote gender equality and ...

International Development Research Centre (IDRC) Digital Library (Canada)

The project will interview about 1,000 workers in more than 20 factories about their employment history, personal background, family relationships, reproductive history, health issues, childcare, and general working ... Institution. Asian Institute of Technology. Pays d' institution. Thailand. Site internet. http://www.ait.asia ...

Browse Title Index

African Journals Online (AJOL)

... hemorrhage mimicking a pneumopathy: a rare complication of dual antiplatelet therapy for ST elevation myocardial infarction, Abstract PDF. Sara Oualim, Charafeddine Ait Elharda, Dounia Benzeroual, Mustapha El Hattaoui. Vol 12, No 1 (2012), Pulmonary epidermoid carcinoma in a patient with acromegaly: a rare entity ...

Three more Mangrove trees growing locally in nature in freshwater

NARCIS (Netherlands)

Steenis, van C.G.G.J.

1984-01-01

In Christmas Island (Indian Ocean) the mangrove trees Bruguiera gymnorrhiza (L.) Sav., B. sexangula (Lour.) Poir. (Rhizophoraceae) and Heritiera littoralis Ait. (Sterculiaceae) are found inland near freshwater springs at some 20-30 m altitude, far from the beach. It is concluded that the inland

Defence Output Measures: An Economics Perspective

Science.gov (United States)

2011-11-01

positive or negative impact of defence spending on growth and there is evidence supporting both impacts! The divergent results reflect the need for a...It also protects national interests, including independence and ‘appropriate sovereignty’ (e.g. protecting a nation’s interests in a globalised

Allergen immunotherapy for insect venom allergy : A systematic review and meta-analysis

NARCIS (Netherlands)

Dhami, S.; Zaman, H.; Varga, Eva-Maria; Sturm, G. J.; Muraro, A.; Akdis, C. A.; Antolin-Amerigo, D.; Bilo, M. B.; Bokanovic, Danijela; Calderon, M. A.; Cichocka-Jarosz, E.; Elberink, J. N. G. Oude; Gawlik, R.; Jakob, T.; Kosnik, M; Lange, J; Mingomataj, Ervin; Mitsias, Dimitris I.; Mosbech, H; Ollert, Markus; Pfaar, O.; Pitsios, Constantinos; Pravettoni, V.; Roberts, G.; Rueff, F.; Sin, Betul Ayse; Asaria, M.; Netuveli, G.; Sheikh, A.

Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines on Allergen Immunotherapy (AIT) for the management of insect venom allergy. To inform this process, we sought to assess the effectiveness, cost-effectiveness and safety of

Yeast Interacting Proteins Database: YDL239C, YKL103C [Yeast Interacting Proteins Database

Lifescience Database Archive (English)

Full Text Available of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle p...ait description Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading

The Scourge of the Spurge Family-An Imitator of Rhus Dermatitis.

Science.gov (United States)

Huerth, Kimberly A; Hawkes, Jason E; Meyer, Laurence J; Powell, Douglas L

The Euphorbiaceae family (commonly known as "spurge") is a large, diverse, and widely distributed family of plants that encompass around 300 genera and more than 8000 species. Their attractiveness and hearty nature have made them popular for both indoor ornamentation and outdoor landscaping. Despite their ubiquity, the potential to cause irritant contact dermatitis (ICD) is often overlooked in favor of more notorious causes of phytodermatitis, namely, Toxicodendron species and nettles. We examined case reports spanning 40 years and discovered that spurge-induced ICD tends to befall children and middle-aged adults who unwittingly encounter the plant through play or horticulture, respectively. Clinical presentation is pleomorphic. Erythema, edema, burning, vesicles, and pruritus of acute onset and rapid resolution are frequently observed. We present a classic case of ICD in a 12-year-old girl after exposure to Euphorbia myrsinites and review the literature on phytodermatitis caused by members of the Euphorbiaceae family.

Chromatographic fingerprint analysis of Pycnogenol® dietary supplements

Science.gov (United States)

French maritime bark (Pinus maritima) has been widely used as an herbal remedy for various degenerative diseases. A standardized bark extract is available that complies with its USP monograph and is derived from Pinus pinaster, Ait. (Pycnogenol®, Horphag Research Ltd., UK). The method specified in...

Confined Disposal Facility and Maintenance Dredging of the Les Cheneaux Island Federal Navigation Channels, Michigan.

Science.gov (United States)

1979-01-01

Methylation of mercury at levels > 1 mg/kg has been documented (1,2). Methyl mercury is directly available for bioaccumulation in the food chain. Elevated...White Pine, Pinus strobus L. Red Pine, Pinus resinosa Ait. Sugar Maple, Acer saccharum Marsh Yellow Birch, Betula alleghaniensis Britton Basswood

EAACI Guidelines on allergen immunotherapy

DEFF Research Database (Denmark)

Pajno, G B; Fernandez-Rivas, M; Arasi, S

2018-01-01

. This Guideline, prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Task Force on Allergen Immunotherapy for IgE-mediated Food Allergy, aims to provide evidence-based recommendations for active treatment of IgE-mediated food allergy with FA-AIT. Immunotherapy relies on the delivery...

Restoring southern Ontario forests by managing succession in conifer plantations

Science.gov (United States)

William C. Parker; Ken A. Elliott; Daniel C. Dey; Eric Boysen

2008-01-01

Thinning and underplanting of conifer plantations to promote natural succession in southern Ontario's forests for restoration purposes was examined in a young red pine (Pinus resinosa Ait.) plantation. Eleven years after application of five thinning treatments, seedling diameter, height, and stem volume of planted white ash (Fraxinus...

Peeter Paani peidupaik / Peter Broeng, Piret Veigel

Index Scriptorium Estoniae

Broeng, Peter

2005-01-01

Shabby chic stiilis sisustatud norra kunstniku ja stilisti Tor Halvorseni Bjornslokkeni talust, kus T. Halvorsen korraldab isiksust ja loovust arendavaid seminare. Elamuks on ümberehitatud ait. Looduslike viimistlusmaterjalide kõrval näeb barokseid küünlajalgu, siidkangaid, modernse joonega disainiklassikat. 12 värv. ill

Mariame El Messal

Indian Academy of Sciences (India)

Home; Journals; Journal of Genetics. Mariame El Messal. Articles written in Journal of Genetics. Volume 86 Issue 2 August 2007 pp 159-163 Research Note. Familial hypercholesterolemia associated with severe hypoalphalipoproteinemia in a Moroccan family · Karima Ait Chihab Rachid Chater Ana Cenarro Anass Kettani ...

DETERMINATION OF DEFENSE MECHANISM IN Phaseolus ...

African Journals Online (AJOL)

Administrator

Field studies were conducted to determine the role of defense mechanism in various parameters associated with plant protection subjected to UV-B radiation in Phaseolus trilobus Ait. commonly used as green manure and fodder. Spectrophotometric analysis showed that UV-B radiation decreases the chlorophyll content ...

Post-fire plant diversity and abundance in pine and eucalypt stands in Portugal : Effects of biogeography, topography, forest type and post-fire management

NARCIS (Netherlands)

Maia, P.; Keizer, J.; Vasques, A.; Abrantes, N.; Roxo, L.; Fernandes, P.; Ferreira, A.; Moreira, F.

2014-01-01

This study concerned the mid-term regeneration of the woody understory vegetation of pure and mixed stands of Pinus pinaster Ait. and Eucalyptus globulus Labill. in northern and central Portugal following wildfires in 2005 and 2006. Pine and eucalypt stands are the most widespread and most

Is the Air Cavalry Training for the Right Missions? The 1st Squadron, 9th Cavalry, 1st Air Cavalry Division Republic of Vietnam - 1965 to 1966.

Science.gov (United States)

1987-06-05

operation--stockpiling ammunition, digging massive underground support systems, and hiding food and ammunition at both the attack sites and withdrawal...was untrained and ineffective. There were nar " diFFerences between the two ccuntries including inowiedge oF the country, the Franch cavalr.I’s ;.ait

Origin and evolution of groundwater in the semi-arid Kerdous Inlier in the Western Anti-Atlas, Morocco

Science.gov (United States)

Heiß, Laura; Bouchaou, Lhoussaine; Reichert, Barbara

2018-03-01

In the Kerdous Inlier, groundwater is the only source of drinking and irrigation water and sustainable management requires an understanding of the hydrogeological setting. In the lower Ait Mansour study site, the main aquifer is represented by a karstified and fractured sequence of Infra and Lower Cambrian carbonates. In the Ameln study site, fractured Neoproterozoic quartzites of the Jebel Lkest build the main aquifer. Isotopic signatures of groundwater indicated direct groundwater recharge in both study sites. In the Ait Mansour study site, isotopic composition implied recharge at high altitudes and groundwater flow in the SE direction. Two major flow paths were identified in the Ameln study site: a shallow and rapid movement until spring discharge at the hill slopes and another deeper one into the Ameln Valley. Hydrochemical facies at both study sites were of Ca-Mg-HCO3 type and derived from dolomite and plagioclase weathering. Increased NO3-, SO4^{2-}, and Cl- concentrations in groundwater indicated an anthropogenic influence.

Effect of exercise training on inflammation status among people with metabolic syndrome.

Science.gov (United States)

Stensvold, Dorthe; Slørdahl, Stig Arild; Wisløff, Ulrik

2012-08-01

Metabolic syndrome is associated with chronic low-grade inflammation, a condition thought to play a key role in the pathogenesis of the syndrome. Among a number of proinflammatory cytokines, interleukin-18 (IL-18) seems to be the best marker for inflammation among people with metabolic syndrome. The aim of this study was to examine the effect of aerobic training versus strength training on circulating IL-18 and other proinflammatory markers in people with metabolic syndrome. Thirty-one inactive men and women with metabolic syndrome were randomized to either high-intensity aerobic interval training (AIT, n=11), strength training (ST, n=10), or a control group (n=10). Exercise training was carried out three times per week for 12 weeks. Serum insulin, high-sensitivity C-reactive protein (hsCRP), IL-18, IL-6, and tumor necrosis factor-α (TNF-α) were measured before and after the intervention. Serum IL-18 was reduced by 43% after AIT (Pmetabolic syndrome. http://clinicaltrials.gov/show/NCT00986024/ .

Selection of patients for sublingual versus subcutaneous immunotherapy.

Science.gov (United States)

Larenas Linnemann, Désirée E S; Blaiss, Michael S

2014-01-01

Allergen immunotherapy is the sole treatment for IgE-mediated allergic diseases directed at the underlying mechanism. The two widely accepted administration routes are sublingual (SLIT) and subcutaneous (SCIT). We reviewed how patients should best be selected for immunotherapy and how the optimal administration route can be defined. Before deciding SCIT or SLIT, appropriate selection of patients for allergen immunotherapy (AIT) is mandatory. To be eligible for AIT, subjects must have a clear medical history of allergic disease, with exacerbation of symptoms on exposure to one or more allergens and a corresponding positive skin or in vitro test. Then the route of administration should be based on: published evidence of clinical and immunologic efficacy (which varies per allergic disease and per allergen); mono- or multi-allergen immunotherapy, for SLIT multi-allergen immunotherapy was not effective; safety: adverse events with SLIT are more frequent, but less severe; and, costs and patient preferences, closely related to adherence issues. All these are discussed in the article.

TÜRKİYE'NİN FARKLI BÖLGELERİNDE ÜRETİLEN DEĞİŞİK TİPTE UNLARIN MİNERAL MADDE MİKTARLARI

Directory of Open Access Journals (Sweden)

Raci EKİNCİ

2002-01-01

Full Text Available Bu araştırmada Türkiye'nin 7 ayrı bölgesine ait 19 farklı ilde un üretimi yapan 30 fabrikadan sağlanan (30 adet Tip 1, 30 adet Tip 2 ve 26 adet Tip 3 toplam 86 un örneğinin kalsiyum, potasyum, magnezyum, demir, çinko, bakır ve mangan miktarları açısından incelenmiştir. Un tipleri açısından ortalama mineral maddelerden; potasyum, magnezyum, demir, mangan değerleri arasında önemli farklılıklar olduğu, diğer özelliklerdeki farklılıkların ise istatistiksel olarak önemli olmadığı tespit edilmiştir. Farklı fabrikalara ait unların mineral maddelerden; kalsiyum, potasyum, demir, çinko, bakır, mangan değerleri arasındaki farklılıklar istatistiksel olarak önemli bulunmuştur.

The Measurement and Prediction of Combustible Properties of Dimethylacetamide (DMAc)

Energy Technology Data Exchange (ETDEWEB)

Ha, Dong-Myeong [Semyung University, Jecheon (Korea, Republic of)

2015-10-15

The usage of the correct combustion characteristic of the treated substance for the safety of the process is critical. For the safe handling of dimethylacetamide (DMAc) being used in various ways in the chemical industry, the flash point and the autoignition temperature (AIT) of DMAc was experimented. And, the lower explosion limit of DMAc was calculated by using the lower flash point obtained in the experiment. The flash points of DMAc by using the Setaflash and Pensky-Martens closed-cup testers measured 61 .deg. C and 65 .deg. C, respectively. The flash points of DMAc by using the Tag and Cleveland automatic open cup testers are measured 68 .deg. C and 71 .deg. C. The AIT of DMAc by ASTM 659E tester was measured as 347 .deg. C. The lower explosion limit by the measured flash point 61 .deg. C was calculated as 1.52 vol%. It was possible to predict lower explosion limit by using the experimental flash point or flash point in the literature.

NanoSIMS analysis of Archean fossils and biomarkers

International Nuclear Information System (INIS)

Kilburn, M.R.; Wacey, D.

2008-01-01

The study of fossils and biomarkers from Archean rocks is of vital importance to reveal how life arose on Earth and what we might expect to find on other planets such as Mars. The Cameca NanoSIMS 50 has the unique ability to measure stable isotopes and map biologically relevant elements at the micron-scale, in situ. This makes it the perfect tool for testing the biogenicity of a range of putative biomarkers from early Archean rocks (∼3.50 billion-year-old). NanoSIMS has been used to investigate ambient inclusion trails (AITs) in a 3.43 Ga beach sand deposit from the Pilbara craton, Western Australia. Chemical maps of the light elements necessary for life (C, N and O) and several transition metals commonly associated with biological processing (Ni, Zn and Fe), coupled with 13 C/ 12 C isotope ratios from carbonaceous linings, strongly suggest a biological component in the formation of AITs

The selection of skin care products for use in hyperbaric chamber may depend on flammability acceptability indices score.

Science.gov (United States)

McCord, Darlene E; Newton, Barry E; Fore, Jane; Chiffoleau, Gwenael

2008-02-01

Current protocols call for stopping adjunctive skin care treatments during hyperbaric oxygen therapy (HBOT) because the hyperbaric environment is considered unsafe for skin care products. The elevated oxygen fraction and the increased pressure in the hyperbaric chamber dramatically increase the flammability potential of materials, leading to the need for rigorous standards to prevent flame ignition. A scientific method of evaluating the flammability risks associated with skin care products would be helpful. Several skin care products were tested, using established industrial techniques for determining flammability potential with some modification. The information obtained from these tests can help clinicians make more rational decisions about which topical products can be used safely on patients undergoing HBOT. Wendell Hull & Associates conducted independent studies, comparing the oxygen compatibility for leading skin care products. Oxygen compatibility was determined using autogenous ignition temperature (AIT), oxygen index (OI), and heat of combustion (HoC) testing. AIT, a relative indication of a material's propensity for ignition, is the minimum temperature needed to cause a sample to self-ignite at a given pressure and oxygen concentration. OI, a relative indication of a material's flammability, is the minimum oxygen percentage that, when mixed with nitrogen, will sustain burning. HoC is the absolute value of a material's energy release when burning, if ignition occurs. Products with a high AIT, a high OI, and a low HoC are more compatible in an oxygen-enriched atmosphere (OEA). An acceptability index (AI) based on these 3 factors was calculated for the products, so the testers could rank overall material compatibility in OEAs (Lapin A. Oxygen Compatibility of Materials. International Institute of Refrigeration Commission Meeting; Brighton, England; 1973). Test results for the skin products varied widely. The AIT, OI, HoC, and AI were determined for each

Volatile components of fruits of Ligustrum lucidum Ait. stimulate ...

African Journals Online (AJOL)

Jane

2011-08-10

Aug 10, 2011 ... investigate the effects of volatile components of FLL on the proliferation and differentiation of rat calvarial ... Yang of the Department of Pharmacy, Fujian University of. Traditional Chinese .... the automated integrator. Statistical ...

Une multitude d'outils à l'appui des partenariats Nord-Sud | CRDI ...

International Development Research Centre (IDRC) Digital Library (Canada)

22 juil. 2011 ... Que leur stratégie d'internationalisation ait été dirigée par des administrateurs ... Comme l'affirme Nina Di Stefano, analyste principale des politiques à ... sur le plan social qu'en ce qui a trait aux capacités ou au recrutement.

United States Transportation Command (USTRANSCOM) 2008 Annual Report

Science.gov (United States)

2008-01-01

enthusiastic about the potential offered by AIT. The DOD currently has the largest active RFID ( aRFID ) system in the world. It provides the ability...to develop the satellite tracking business case for those situations where the aRFID infrastructure is less robust or nonexistent. USTRANSCOM is also

CLOSED LOOP AOCS TESTING OF AN AUTONOMOUS STAR TRACKER

DEFF Research Database (Denmark)

Jørgensen, John Leif

1999-01-01

not even a high quality star pattern generator may be able to pass the outlier rejection filtering of the ASC thus efficiently precluding artificial stimuli during AIT tests. In order to circumvent this impasse, the ASC has a series of build-in features enabling simple, yet comprehensive, closed loop...

Villa- ja teetööstuse mõis / Helju Koger

Index Scriptorium Estoniae

Koger, Helju, 1943-

2006-01-01

Räägu mõisast, kus praegu tegutseb Oru valla hooldekodu. Peahoone valmis 1835. a. Ait-kuivati müüridele on ehitatud abihoone. Söögisaalis on kohaliku harrastuskunstniku Aive Nõupuu seinamaalingud. Mõisas vändati kaadreid telefilmile "Kahe kodu ballaad". Mõisa kunagisest omanikust Rudolf Krupist. 11 ill

Ce que nous faisons | Page 150 | CRDI - Centre de recherches pour ...

International Development Research Centre (IDRC) Digital Library (Canada)

Transformation de l'économie non structurée depuis la fin du conflit en Angola. En 2002, l'Angola émergeait de 40 ans de conflit, l'une des plus longues guerres civiles qu'ait connues l'Afrique. Angola, Nord Du Sahara, Sud Du Sahara, Chine. PROJECT ...

Techtalk: Mobile Apps and College Mathematics

Science.gov (United States)

Hoang, Theresa V.; Caverly, David C.

2013-01-01

In this column, the authors discuss apps useful in developing mathematical reasoning. They place these into a theoretical framework, suggesting how they could be used in an instructional model such as the Algorithmic Instructional Technique (AIT) developed by Vasquez (2003). This model includes four stages: modeling, practice, transition, and…

Interval and continuous exercise enhances aerobic capacity and hemodynamic function in CHF rats

Directory of Open Access Journals (Sweden)

Ramiro B. Nunes

2015-08-01

Full Text Available OBJECTIVE: The aim of the present study was to compare the effects of continuous versus interval aerobic exercise training on hemodynamic parameters, cardiac remodeling, and maximal exercise capacity (MEC in chronic heart failure (CHF rats.METHOD: Twenty-four male Wistar rats were subjected to myocardial infarction (MI surgery. Five weeks post MI, the animals were assigned to one of three groups: sedentary group (CHF-Sed, n=8, aerobic continuous training group (CHF-ACT, n=8, and aerobic interval training group (CHF-AIT, n=8. Treadmill training was performed five times a week for 8 weeks (ACT: 50 min/day at 15 m/min and AIT: 40 min/day with 8 min of warm-up at 10 m/min and exercise at 15 m/min 4×4 min interspersed with 4×4 min at 23 m/min. MEC was evaluated pre and post exercise program.RESULTS: Left ventricular end-diastolic pressure (LVEDP, left ventricular mass/body mass ratio (LVM:BM, and total collagen volume fraction were lower in the trained groups compared with the sedentary group, but no difference was found between the trained groups. Systolic ventricular pressure (SVP and maximum positive derivative of LV pressure (+dP/dtmax were higher in the trained groups, but CHF-ACT showed higher +dP/dtmax compared to CHF-AIT. Both training regimens were able to increase MEC. However, the aerobic interval training was superior for improving MEC.CONCLUSION: Aerobic training is an important intervention to improve cardiac function and remodeling and physical capacity in CHF rats. Interval training is a potential strategy to maximize the results, but exercise type and intensity are still topics to be explored.

Hyperbaric Oxygen Therapy and Oxygen Compatibility of Skin and Wound Care Products.

Science.gov (United States)

Bernatchez, Stéphanie F; Tucker, Joseph; Chiffoleau, Gwenael

2017-11-01

Objective: Use test methods to assess the oxygen compatibility of various wound care products. Approach: There are currently no standard test methods specifically for evaluating the oxygen compatibility and safety of materials under hyperbaric oxygen (HBO) conditions. However, tests such as the oxygen index (OI), oxygen exposure (OE), and autogenous ignition temperature (AIT) can provide useful information. Results: The OI test measures the minimum oxygen concentration that will support candle-like burning, and it was used to test 44 materials. All but two exhibited an OI equal to or greater (safer) than a control material commonly used in HBO. The OE test exposes each material to an oxygen-enriched atmosphere (>99.5% oxygen) to monitor temperature and pressure for an extended duration. The results of the OE testing indicated that none of the 44 articles tested with this method self-ignited within the 60°C, 3 atm pressurized oxygen atmosphere. The AIT test exposes materials to a rapid ramp up in temperature in HBO conditions at 3 atm until ignition occurs. Ten wound care materials and seven materials usually avoided in HBO chambers were tested. The AIT ranged from 138°C to 384°C for wound care products and from 146°C to 420°C for the other materials. Innovation: This work provides useful data and recommendations to help develop a new standard approach for evaluating the HBO compatibility of wound care products to ensure safety for patients and clinicians. Conclusion: The development of an additional test to measure the risk of electrostatic discharge of materials in HBO conditions is needed.

First report of the effect of Ocotea elegans essential oil on Rhipicephalus (Boophilus) microplus.

Science.gov (United States)

Figueiredo, Amanda; Nascimento, Leonor M; Lopes, Louyse G; Giglioti, Rodrigo; Albuquerque, Ricardo D D G; Santos, Marcelo G; Falcão, Deborah Q; Nogueira, Jeane A P; Rocha, Leandro; Chagas, Ana Carolina S

2018-03-15

Rhipicephalus (Boophilus) microplus is responsible for reducing animal welfare, causing a drop in productive performance and transmitting hemoparasites. The main strategy of tick control is application of synthetic acaricides. However, parasite resistance to these compounds is a major concern. Therefore, the acaricidal and repellent in vitro effect of the Ocotea elegans essential oil on larvae and adult females of R. (B.) microplus were evaluated. The larval packet test (LPT), larval repellency test (RT) and adult immersion test (AIT) were performed. The essential oil was analyzed by gas chromatography (GC/FID) and the structure of the oil's major constituent (92.2% sesquirosefuran) was elucidated by nuclear magnetic resonance. In the AIT, efficacy higher than 90% was detected from the concentration 25 mg/mL upward. In both LPTs performed after 48 h, only the 100 mg/mL concentration resulted in mortalities above 70%. On the other hand, the essential oil caused an average of 95.8% repellency from 0.78 to 100 mg/mL. The LC 50 in the two LPT (48 h) tests were 59.68 and 25.59 mg/mL, respectively. The LC 50 and LC 90 in the AIT were 4.96 and 17.37 mg/mL, and in the RT they were 0.04 and 1.24 mg/mL respectively. We conclude that the essential oil of O. elegans leaves has a significant acaricidal effect on engorged females and on larval repellency of R. (B.) microplus ticks, and can be a promising alternative for the control of this ectoparasite. Copyright © 2018. Published by Elsevier B.V.

The Type 3 copper site is intact but labile in Type 2-depleted laccase

DEFF Research Database (Denmark)

Frank, P; Farver, O; Pecht, I

1983-01-01

We report results of experiments designed to characterize the Type 1 and Type 3 copper sites in Rhus laccase depleted of Type 2 copper (T2D). Use of the Lowry method for determining protein concentration yielded the value 5620 +/- 570 M-1 cm-1 for the extinction of the 615-nm absorption band...... as intensity perturbations at 280 and 615 nm. Comparison of difference spectra show that this 330-nm band derives from a Type 3 copper-bound peroxide and not from a reoxidized Type 3 site. Dioxygen reoxidation of ascorbate-reduced T2D laccase produced new difference bands at 330 nm (delta epsilon = 770 M-1 cm...

Swedes in trouble!

DEFF Research Database (Denmark)

Christiansen, Ask Vest

2011-01-01

in the EU context – that the ban is contrary to the free movement of goods and services within the Union. The argument from the EU that snus is harmful is blatantly hypocritical – a cigarette, anyone? The EU Tobacco Directive is presently being revised, and the Swedish government is on the case. We’ll know......, though, it only concerns oral tobacco products, primarily snus. A lot of people are rolling their eyes at this, among them Ask Vest Christiansen, who, from his position at the Department of Sport Science in Århus, keeps a watchful eye and a critical look at WADA’s many excesses. In a column...

High-Intensity Interval Training in Normobaric Hypoxia Leads to Greater Body Fat Loss in Overweight/Obese Women than High-Intensity Interval Training in Normoxia

Directory of Open Access Journals (Sweden)

Alba Camacho-Cardenosa

2018-02-01

Full Text Available A moderate hypoxic stimulus is considered a promising therapeutic modality for several pathological states including obesity. There is scientific evidence suggesting that when hypoxia and physical activity are combined, they could provide benefits for the obese population. The aim of the present study was to investigate if exposure to hypoxia combined with two different protocols of high-intensity interval exercise in overweight/obese women was more effective compared with exercise in normoxia. Study participants included 82 overweight/obese women, who started a 12 week program of 36 sessions, and were randomly divided into four groups: (1 aerobic interval training in hypoxia (AitH; FiO2 = 17.2%; n = 13, (2 aerobic interval training in normoxia (AitN; n = 15, (3 sprint interval training in hypoxia (SitH; n = 15, and (4 sprint interval training in normoxia (SitN; n = 18. Body mass, body mass index, percentage of total fat mass, muscle mass, basal metabolic rate, fat, and carbohydrate oxidation, and fat and carbohydrate energy were assessed. Outcomes were measured at baseline (T1, after 18 training sessions (T2, 7 days after the last session (T3, and 4 weeks after the last session (T4. The fat mass in the SitH group was significantly reduced compared with the SitN group from T1 to T3 (p < 0.05 and from T1 to T4 (p < 0.05 and muscle mass increased significantly from T1 to T4 (p < 0.05. Fat mass in the AitH group decreased significantly (p < 0.01 and muscle mass increased (p = 0.022 compared with the AitN group from T1 to T4. All training groups showed a reduction in the percentage of fat mass, with a statistically significant reduction in the hypoxia groups (p < 0.05. Muscle mass increased significantly in the hypoxia groups (p < 0.05, especially at T4. While fat oxidation tended to increase and oxidation of carbohydrates tended to decrease in both hypoxia groups, the tendency was reversed in the normoxia groups. Thus, high-intensity interval

IgE and allergen-specific immunotherapy-induced IgG4 recognize similar epitopes of Bet v 1, the major allergen of birch pollen.

Science.gov (United States)

Groh, N; von Loetzen, C S; Subbarayal, B; Möbs, C; Vogel, L; Hoffmann, A; Fötisch, K; Koutsouridou, A; Randow, S; Völker, E; Seutter von Loetzen, A; Rösch, P; Vieths, S; Pfützner, W; Bohle, B; Schiller, D

2017-05-01

Allergen-specific immunotherapy (AIT) with birch pollen generates Bet v 1-specific immunoglobulin (Ig)G 4 which blocks IgE-mediated hypersensitivity mechanisms. Whether IgG 4 specific for Bet v 1a competes with IgE for identical epitopes or whether novel epitope specificities of IgG 4 antibodies are developed is under debate. We sought to analyze the epitope specificities of IgE and IgG 4 antibodies from sera of patients who received AIT. 15 sera of patients (13/15 received AIT) with Bet v 1a-specific IgE and IgG 4 were analyzed. The structural arrangements of recombinant (r)Bet v 1a and rBet v 1a _11x , modified in five potential epitopes, were analyzed by circular dichroism and nuclear magnetic resonance spectroscopy. IgE binding to Bet v 1 was assessed by ELISA and mediator release assays. Competitive binding of monoclonal antibodies specific for Bet v 1a and serum IgE/IgG 4 to rBet v 1a and serum antibody binding to a non-allergenic Bet v 1-type model protein presenting an individual epitope for IgE was analyzed in ELISA and western blot. rBet v 1a _11x had a Bet v 1a - similar secondary and tertiary structure. Monomeric dispersion of rBet v 1a _11x was concentration and buffer-dependent. Up to 1500-fold increase in the EC 50 for IgE-mediated mediator release induced by rBet v 1a _11x was determined. The reduction of IgE and IgG 4 binding to rBet v 1a _11x was comparable in 67% (10/15) of sera. Bet v 1a-specific monoclonal antibodies inhibited binding of serum IgE and IgG 4 to 66.1% and 64.9%, respectively. Serum IgE and IgG 4 bound specifically to an individual epitope presented by our model protein in 33% (5/15) of sera. Patients receiving AIT develop Bet v 1a-specific IgG 4 which competes with IgE for partly identical or largely overlapping epitopes. The similarities of epitopes for IgE and IgG 4 might stimulate the development of epitope-specific diagnostics and therapeutics. © 2016 John Wiley & Sons Ltd.

Rapport annuel

International Development Research Centre (IDRC) Digital Library (Canada)

1 janv. 2018 ... En avril 2015, le CRDI lançait son Plan stratégique 2015-. 2020 : Investir .... C'est dans cet esprit que la nouvelle Politique de libre accès du CRDI ...... mise en place afin d'améliorer les processus de recrutement, de formation ...

A dendrochronological fire history of Opeongo lookout in Algonquin Park, Ontario

Science.gov (United States)

Richard P. Guyette; Daniel C. Dey

1995-01-01

Fire-scarred stumps and natural snags of red pine (Pinus resinosa Ait.) on a 70-m tall bluff along Costello Creek, 2 km south of Lake Opeongo, were dated using dendrochronological methods. A fire scar chronology was constructed from 18 of the red pine samples that contained 34 dated fire scars.

Обоюдоострая Марина / Рамуте Скучайте ; беседу ведет публицист Татьяна Ясинская

Index Scriptorium Estoniae

Скучайте, Рамуте, 1931-

2009-01-01

Leedu luuletaja ja tõlkija Ramutė Skučaitė oma elust väljasaadetuna Siberis 1949-1956. Ka on ta tõlkinud Marina Tsvetajeva loomingut leedu keelde, ilmunud on Tsvetajeva kakskeelne tõlkekogumik "Письма в никуда" (Vilnius : Kronta, 2008)

A comparative study on Cu, Cr and As removal from CCA-treated wood waste by dialytic and electrodialytic processes

DEFF Research Database (Denmark)

Velizarova, Emiliya; Ribeiro, Alexandra B.; Ottosen, Lisbeth M.

2002-01-01

In this study, electrodialytic and dialytic techniques were used for Cu, Cr and As removal from 20-years out-of-service CCA-treated Pinus pinaster Ait. pole. The effect of applying direct current, as "cleaning agent", of up to 120mA was investigated. Focus was given to a parallel comparison...

: tous les projets | Page 508 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

En 2002, l'Angola émergeait de 40 ans de conflit, l'une des plus longues guerres civiles qu'ait connues l'Afrique. Date de début : 13 mars 2007. End Date: 7 septembre 2009. Sujet: ECONOMIC RECONSTRUCTION, INFORMAL SECTOR, INCOME GENERATION, EMPLOYMENT, SOCIAL EQUITY. Région: Angola, North of ...

The Austrian x red pine hybrid

Science.gov (United States)

W. B. Critchfield

1963-01-01

The genetic improvement of red pine (Pinus resinosa Ait.) presents tree breeders with one of their most difficult problems. Not only is this valuable species remarkably uniform, but until 1955 it resisted all attempts to cross it with other pines. In that year red pine and Austrian pine (P. nigra var. austriaca [...

Initial Human Response to Nuclear Radiation

Science.gov (United States)

1982-04-01

symptomatic response to radiation. In the second phase, the models will be used to infer performance effects. DNA staff members Cyrus Knowles and David ...P. Setty ATTN: K. Schwartz ATTN: J. NcGahan Kamn Tempo System Planning Corp ATTN: R. Miller ATTN: J. JonesATTN: G. Perks Kamen Tempo AiT: S. Shrier

Histone Code Modulation by Oncogenic PWWP-Domain Protein in Breast Cancers

Science.gov (United States)

2014-08-01

the pathogenesis of a wide range of human cancers, including colon, lung, glioblastoma and mela - noma (Ostman et al., 2006; Solomon et al., 2008...Beroukhim R, Mermel CH, Loda M, Ait-Si-Ali S, Garraway LA, Young RA and Zon LI. The histone methyltrans- ferase SETDB1 is recurrently amplified in mela

In-vitro antibacterial activity of essential oils extracted from locally available medicinal plants

International Nuclear Information System (INIS)

Ara, G.; Shawar, D.; Akbar, A.; Kanwal, F.; Imran, M.

2011-01-01

Extraction of essential oils from locally available species of four plants, Nigella sativa, Syzygium aromaticum, Cinnamomum tenuis and Curcuma aromatica was carried out using steam distillation followed by ether extraction. Dried and purified extracted oils were screened for their antibacterial activity against three bacterial strains namely, Bacillus lichaniformis (Gram +ve), Micrococcus leutus (Gram +ve) and Salmonella Typhimurium (Gram -ve) using Mc. Cartney's method. Minimum Inhibition Concentration (MIC) values of these oils were also determined. It was observed that the oils extracted from Nigella sativa and Cinnamomum tenuis were found to be more potent as compared to other two species. With the exception of Nigella sativa, all the other oils showed bacterial inhibition at 50 mmol concentration. These results support that these plant oils can be used to cure bacterial infections and may also have role as pharmaceuticals and preservatives. (author)

High-Intensity Interval Training in Normobaric Hypoxia Leads to Greater Body Fat Loss in Overweight/Obese Women than High-Intensity Interval Training in Normoxia.

Science.gov (United States)

Camacho-Cardenosa, Alba; Camacho-Cardenosa, Marta; Burtscher, Martin; Martínez-Guardado, Ismael; Timon, Rafael; Brazo-Sayavera, Javier; Olcina, Guillermo

2018-01-01

A moderate hypoxic stimulus is considered a promising therapeutic modality for several pathological states including obesity. There is scientific evidence suggesting that when hypoxia and physical activity are combined, they could provide benefits for the obese population. The aim of the present study was to investigate if exposure to hypoxia combined with two different protocols of high-intensity interval exercise in overweight/obese women was more effective compared with exercise in normoxia. Study participants included 82 overweight/obese women, who started a 12 week program of 36 sessions, and were randomly divided into four groups: (1) aerobic interval training in hypoxia (AitH; FiO 2 = 17.2%; n = 13), (2) aerobic interval training in normoxia (AitN; n = 15), (3) sprint interval training in hypoxia (SitH; n = 15), and (4) sprint interval training in normoxia (SitN; n = 18). Body mass, body mass index, percentage of total fat mass, muscle mass, basal metabolic rate, fat, and carbohydrate oxidation, and fat and carbohydrate energy were assessed. Outcomes were measured at baseline (T1), after 18 training sessions (T2), 7 days after the last session (T3), and 4 weeks after the last session (T4). The fat mass in the SitH group was significantly reduced compared with the SitN group from T1 to T3 ( p Fat mass in the AitH group decreased significantly ( p fat mass, with a statistically significant reduction in the hypoxia groups ( p fat oxidation tended to increase and oxidation of carbohydrates tended to decrease in both hypoxia groups, the tendency was reversed in the normoxia groups. Thus, high-intensity interval training under normobaric intermittent hypoxia for 12 weeks in overweight/obese women seems to be promising for reducing body fat content with a concomitant increase in muscle mass.

Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1.

Science.gov (United States)

Sirvent, Sofía; Soria, Irene; Cirauqui, Cristina; Cases, Bárbara; Manzano, Ana I; Diez-Rivero, Carmen M; Reche, Pedro A; López-Relaño, Juan; Martínez-Naves, Eduardo; Cañada, F Javier; Jiménez-Barbero, Jesús; Subiza, Javier; Casanovas, Miguel; Fernández-Caldas, Enrique; Subiza, José Luis; Palomares, Oscar

2016-08-01

Allergen immunotherapy (AIT) is the only curative treatment for allergy. AIT faces pitfalls related to efficacy, security, duration, and patient compliance. Novel vaccines overcoming such inconveniences are in demand. We sought to study the immunologic mechanisms of action for novel vaccines targeting dendritic cells (DCs) generated by coupling glutaraldehyde-polymerized grass pollen allergoids to nonoxidized mannan (PM) compared with glutaraldehyde-polymerized allergoids (P) or native grass pollen extracts (N). Skin prick tests and basophil activation tests with N, P, or PM were performed in patients with grass pollen allergy. IgE-blocking experiments, flow cytometry, confocal microscopy, cocultures, suppression assays, real-time quantitative PCR, ELISAs, and ELISpot assays were performed to assess allergen capture by human DCs and T-cell responses. BALB/c mice were immunized with PM, N, or P. Antibody levels, cytokine production by splenocytes, and splenic forkhead box P3 (FOXP3)(+) regulatory T (Treg) cells were quantified. Experiments with oxidized PM were also performed. PM displays in vivo hypoallergenicity, induces potent blocking antibodies, and is captured by human DCs much more efficiently than N or P by mechanisms depending on mannose receptor- and dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin-mediated internalization. PM endorses human DCs to generate functional FOXP3(+) Treg cells through programmed death ligand 1. Immunization of mice with PM induces a shift to nonallergic responses and increases the frequency of splenic FOXP3(+) Treg cells. Mild oxidation impairs these effects in human subjects and mice, demonstrating the essential role of preserving the carbohydrate structure of mannan. Allergoids conjugated to nonoxidized mannan represent suitable vaccines for AIT. Our findings might also be of the utmost relevance to development of therapeutic interventions in other immune tolerance-related diseases. Copyright �

High-dose bee venom exposure induces similar tolerogenic B-cell responses in allergic patients and healthy beekeepers.

Science.gov (United States)

Boonpiyathad, T; Meyer, N; Moniuszko, M; Sokolowska, M; Eljaszewicz, A; Wirz, O F; Tomasiak-Lozowska, M M; Bodzenta-Lukaszyk, A; Ruxrungtham, K; van de Veen, W

2017-03-01

The involvement of B cells in allergen tolerance induction remains largely unexplored. This study investigates the role of B cells in this process, by comparing B-cell responses in allergic patients before and during allergen immunotherapy (AIT) and naturally exposed healthy beekeepers before and during the beekeeping season. Circulating B cells were characterized by flow cytometry. Phospholipase A2 (PLA)-specific B cells were identified using dual-color staining with fluorescently labeled PLA. Expression of regulatory B-cell-associated surface markers, interleukin-10, chemokine receptors, and immunoglobulin heavy-chain isotypes, was measured. Specific and total IgG1, IgG4, IgA, and IgE from plasma as well as culture supernatants of PLA-specific cells were measured by ELISA. Strikingly, similar responses were observed in allergic patients and beekeepers after venom exposure. Both groups showed increased frequencies of plasmablasts, PLA-specific memory B cells, and IL-10-secreting CD73 - CD25 + CD71 + B R 1 cells. Phospholipase A2-specific IgG4-switched memory B cells expanded after bee venom exposure. Interestingly, PLA-specific B cells showed increased CCR5 expression after high-dose allergen exposure while CXCR4, CXCR5, CCR6, and CCR7 expression remained unaffected. This study provides the first detailed characterization of allergen-specific B cells before and after bee venom tolerance induction. The observed B-cell responses in both venom immunotherapy-treated patients and naturally exposed beekeepers suggest a similar functional immunoregulatory role for B cells in allergen tolerance in both groups. These findings can be investigated in other AIT models to determine their potential as biomarkers of early and successful AIT responses. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

l'instabilité financière et les enseignements à tirer des pays émergents

International Development Research Centre (IDRC) Digital Library (Canada)

bbattisti

Macroeconomic Volatility, Institutions and Financial Architectures. (José María Fanelli, éditeur, Palgrave Macmillan, 2008). La crise internationale et l'inquiétude face à la croissance future. L'instabilité financière actuelle est la pire que le monde ait connue depuis des décennies. De nombreux observateurs avancent que.

Aziz Nesin

OpenAIRE

2016-01-01

Taha Toros Arşivi, Dosya No: 56-Aziz Nesin. Not: Metin ekli dokümanın 13. sayfasında yer almaktadır. Gazetenin "Ankara Kulisi" köşesinde yayımlanmıştır. Ekte Aziz Nesin'e ait "Dizelerin Dilinden" isimli şiir bulunmaktadır.

Philippines : tous les projets | Page 2 | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Région: Argentina, South America, Brazil, India, Kenya, Nigeria, Nepal, Far East Asia, Philippines, Uruguay, South Africa, North of Sahara, South of Sahara, ... Le projet Innovation scientifique et technologique au service des groupes à la " base de la pyramide " - Asie du Sud-Est (no 104904) que finançait le CRDI et qui ...

Time-of-Flight Adjustment Procedure for Acoustic Measurements in Structural Timber

Science.gov (United States)

Danbiel F. Llana; Guillermo Iñiguez-Gonzalez; Francisco Arriaga; Xiping Wang

2016-01-01

The effect of timber length on time-of-flight acoustic longitudinal measurements was investigated on the structural timber of four Spanish species: radiata pine (Pinus radiata D. Don), Scots pine (Pinus sylvestris L.), laricio pine (Pinus nigra Arn.), and maritime pine (Pinus pinaster Ait.). Time-of-flight longitudinal measurements were conducted on 120 specimens of...

Benchmarking EUV mask inspection beyond 0.25 NA

International Nuclear Information System (INIS)

Goldberg, Kenneth A.; Mochi, Iacopo; Anderson, Erik H.; Rekawa, Seno B.; Kemp, Charles D.; Huh, S.; Han, H.-S.; Naulleau, P.; Gunion, R.F.

2008-01-01

The SEMATECH Berkeley Actinic Inspection Tool (AIT) is an EUV-wavelength mask inspection microscope designed for direct aerial image measurements, and pre-commercial EUV mask research. Operating on a synchrotron bending magnet beamline, the AIT uses an off-axis Fresnel zoneplate lens to project a high-magnification EUV image directly onto a CCD camera. We present the results of recent system upgrades that have improved the imaging resolution, illumination uniformity, and partial coherence. Benchmarking tests show image contrast above 75% for 100-nm mask features, and significant improvements and across the full range of measured sizes. The zoneplate lens has been replaced by an array of user-selectable zoneplates with higher magnification and NA values up to 0.0875, emulating the spatial resolution of a 0.35-NA 4 x EUV stepper. Illumination uniformity is above 90% for mask areas 2-(micro)m-wide and smaller. An angle-scanning mirror reduces the high coherence of the synchrotron beamline light source giving measured σ values of approximately 0.125 at 0.0875 NA

BİLGİSAYAR AĞLARINDA GÜVENLİ MESAJLAŞMA İÇİN AKILLI KART DESTEKLİ BİR SİSTEM MİMARİSİ

Directory of Open Access Journals (Sweden)

Geylani KARDAŞ

2008-01-01

Full Text Available Bu çalışmada, bilgisayar ağlarında güvenli mesaj alışverişi için akıllı kart olanaklarından yararlanan taşınabilir bir sistem mimarisi tanıtılmaktadır. Akıllı kartların sistem mimarisi bünyesinde yer alması mesaj alışverişlerinde kimlik denetimi ve mahremiyet gibi başlıca iki önemli güvenlik hizmetini sunmaktadır. İletişimlerde asimetrik şifrelemenin uygulanması hedeflendiği için akıllı kartlar, kullanıcılarına ait hesap bilgilerinin yanı sıra ilgili asimetrik şifreleme için yine kullanıcılarına ait özel anahtarları saklamaktadırlar. Önerilen sistemin JavaCard teknolojisi kullanılarak gerçek bir uygulaması da yine bu çalışma içerisinde sunulmuştur.

LEARNING STYLES BASED ADAPTIVE INTELLIGENT TUTORING SYSTEMS: DOCUMENT ANALYSIS OF ARTICLES PUBLISHED BETWEEN 2001. AND 2016.

Directory of Open Access Journals (Sweden)

Amit Kumar

2017-12-01

Full Text Available Actualizing instructional intercessions to suit learner contrasts has gotten extensive consideration. Among these individual contrast factors, the observational confirmation in regards to the academic benefit of learning styles has been addressed, yet the examination on the issue proceeds. Late improvements in web-based executions have driven researchers to re-examine the learning styles in adaptive tutoring frameworks. Adaptivity in intelligent tutoring systems is strongly influenced by the learning style of a learner. This study involved extensive document analysis of adaptive tutoring systems based on learning styles. Seventy-eight studies in literature from 2001 to 2016 were collected and classified under select parameters such as main focus, purpose, research types, methods, types and levels of participants, field/area of application, learner modelling, data gathering tools used and research findings. The current studies reveal that majority of the studies defined a framework or architecture of adaptive intelligent tutoring system (AITS while others focused on impact of AITS on learner satisfaction and academic outcomes. Currents trends, gaps in literature and ications were discussed.

ÇİVRİL İLÇESİ (DENİZLİ VE YAKIN ÇEVRESİNİN HİDROJEOLOJİ İNCELEMESİ

Directory of Open Access Journals (Sweden)

Suat TAŞDELEN

2001-02-01

Full Text Available Bu çalışmada, Çivril (Denizli ve yakın çevresinin hidrojeolojik açıdan incelemesi yapılmıştır. Öncelikle, İlçe merkezi ve yakın çevresinde yapılan arazi çalışmaları ile elde edilen jeolojik, tektonik ve hidrolojik bilgiler verilmiştir. Eylül 1999 dönemine ait yerinde ölçüm ve gözlemlerle yeraltı su tablası haritası hazırlanarak, yeraltı suyu akım yönleri belirlenmiştir. Aynı dönemde, örneklenen kuyulara ait yeraltı suları üzerinde su kimyası çalışmaları yapılarak, bu suların kimyasal sınıflamaları ile içme, sulama ve endüstride kullanım özellikleri belirlenmiştir. Elde edilen bilgiler birlikte irdelenerek varılan sonuçlar tablo ve diyagramlarla sunulmuştur.

Kuva-yi Milliye Müzesindeki Sırp Kralı II. Stefan Uroš Milutin (1282-1321 Dönemine Ait Gümüş Sikke A Silver Coin of Serbian King Stephan Uros II Milutin (1282-1321 from Kuva-yi Milliye Museum

Directory of Open Access Journals (Sweden)

Ceren ÜNAL

2012-12-01

Full Text Available Museum of Kuva-yi Milliye in Balıkesir which is located in thenorth-western part of Turkey was established in 1996. The Museum ofKuva-yi Milliye has approximately 2.500 coins from different culturesand ages. As a result of some research, done between 2011-2012August, one rare silver coin which dated back to Medieval era of Serbiawas detected.There is a silver dinar of Serbian king Stephen Uroš II Milutin(1282-1321 in Kuva-yi Milliye Museum which might have come toAnatolia with the international trade route. Serbian silver dinar wasfound together with a group of Venetian silver coins and it was wronglyclassified to Byzantine Empire which was an effective culture in thatera. Most probably, Serbian silver coin which was dated back to the endof the 13th century, might have come to the Anatolia with a trade ofVenetia. The coin which is protected in the Museum is the reflection of arich culture of Anatolia which is the center of overseas trade betweenEast and West.When Byzantine Empire began to lose its power in 12th century,the idea of independence between Balkan communities developed.Serbian Kingdom which was established in 12th century was gettingstronger gradually and its borders were extended. Therefore, SerbianKingdom reached a balance situation between the West and ByzantineEmpire. As the Serbian Kingdom, was located on the overland journeybetween the West and the East, it had effective relations with itswestern alliances. Because of its strategical location, Byzantine Empirehad to have good relations with them.This rare silver dinar most probably came to Anatolia with theVenetian merchants who were dominant in the sea trade in that era. Itwill be presented with the help of the historical background of theBalkans and Serbia. Türkiye’nin kuzeybatısında, Balıkesir ilinde yer alan Kuva-yi Milliye Müzesi 1996 yılında kurulmuştur. Kuva-yi Milliye Müzesi’nde yaklaşık olarak 2.500 adet farklı kültürler ve dönemlere ait sikke

Lejere der bliver sat ud af deres bolig

DEFF Research Database (Denmark)

Christensen, Gunvor; Nielsen, Torben Heien

Antallet af lejere, der bliver sat ud af deres bolig, er steget i perioden 2002-06. I 2006 blev 2600 husstande, svarende til 0,1 pct. af samtlige husstande i Danmark, sat ud af deres bolig. Stigningen er især sket i de fem største byer: København, Århus, Odense, Ålborg og Esbjerg. I dette...... skal give viden om, hvilke årsager der er til, at nogle lejere bliver sat ud af deres bolig, og hvorfor der er sket en stigning i antallet af udsættelser. Den endelige afrapportering af undersøgelsen af udsættelser i Danmark vil ske i foråret 2008. Undersøgelsen er finansieret af Socialministeriet....

Non-native tree species in urban areas of the city of Nitra

International Nuclear Information System (INIS)

Galis, M

2014-01-01

Non-native plant species are part of our environment. The introduction of these species is huge conditioned by anthropogenic activities, such as the urban environment is characterized by. During the field surveys of selected town Nitra (Chrenova, Mikova Ves, Zobor), we studied the frequency of non-native tree species in the contact zone. Overall, we found out the presence of 10 alien species, observed in this area. Our results show dominant presence of the species Rhus typhina, followed by the Robinia pseudoacacia and Ailanthus altissima. Individual plants were tied largely to the surrounding of built-up areas, often growns directly in front of houses, or as a part of urban green. (author)

Supply Chain Management og Supply Chain costing

DEFF Research Database (Denmark)

Nielsen, Steen; Mortensen, Ole

2002-01-01

Formålet med denne artikel er at belyse de muligheder som ligger i at integrere virksomhedens økonomiske styring med begrebet Supply Chain Management (SCM). Dette søges belyst ved først at beskrive den teoretiske ramme, hvori SCM indgår. Herefter analyseres begrebet Supply Chain Costing (SCC) som...... Århus. Et resultat er, at via begrebet Supply Chain Costing skabes der mulighed for at måle logistikkædens aktiviteter i kr./øre. Anvendelsen af denne information har også strategisk betydning for at kunne vælge kunde og leverandør. Ved hjælp af integrationen skabes der også helt nye mulighed...

Phenotype-gene: 740 [Arabidopsis Phenome Database[Archive

Lifescience Database Archive (English)

Full Text Available ait of behavioral quality during process named response to gravity for AT5G06140 Jaillais Yvon et al. 2006 S... trait of behavioral quality during process named response to gravity http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u541i AT5G06140

GBP6: differential expression in pulmonary alveolar macrophages ...

African Journals Online (AJOL)

Adeyinka A.A

2017-08-14

Aug 14, 2017 ... Through a linear mixed effects model, the polymorphism of the mutation ... information for the function and possible involvement of the GBP6 gene in ..... in the lung was important in the immune surveillance system in the organs of the ... Ait-ali, T., Wilson, A. D., Westcott, D. G., Clapperton, M., Waterfall, M., ...

Radiation Effects on the Electrical Properties of MOS Device Materials.

Science.gov (United States)

1978-02-01

distance to be collected at the gate so the current is essentially due to holes traversing the oxide to be collected at the silicon cathode . 3.2.2 Dose...CA 94025 San Bernardino, CA 92402 Attn : M.L. Aite l NCA 1-3236 Attn: P.J. Dolan Attn : E.W. Allen 520/141 Science Application s, Inc Stanford Research

Effects of Modality and Redundancy Principles on the Learning and Attitude of a Computer-Based Music Theory Lesson among Jordanian Primary Pupils

Science.gov (United States)

Aldalalah, Osamah Ahmad; Fong, Soon Fook

2010-01-01

The purpose of this study was to investigate the effects of modality and redundancy principles on the attitude and learning of music theory among primary pupils of different aptitudes in Jordan. The lesson of music theory was developed in three different modes, audio and image (AI), text with image (TI) and audio with image and text (AIT). The…

Browse Title Index

African Journals Online (AJOL)

Vol 1, No 1 (2005), Industrial water demand management and cleaner production potential: a case of beverage industry in Marrakech - Morocco, Abstract. E Ait Hsine, A Benhammou, M-N Pons. Vol 1, No 2 (2005), Influence de la phosphatation au zinc sur la résistance a la corrosion d'un acier au carbone en milieu maring ...

Sour grapes: multiple groundwater enclosures in Morocco's Saïss region

NARCIS (Netherlands)

Bossenbroek, L.; Kuper, M.; Zwarteveen, M.Z.

2017-01-01

While driving to the douar 1 Ait Ali in the agricultural plain of the Saïss in Morocco, we always passed by a fallow land plot of approximately 10 hectares. We passed this plot without noticing much, until the day we spotted a Syrian tube-well driller with a checked red scarf on his head and his

Capacité de la biopsie de la prostate à prédire le score réel du ...

African Journals Online (AJOL)

Y. Dehayni

Disponible sur Internet le 8 août 2016. MOTS CLÉS .... Les résultats de notre étude ont démontré que bien qu'il y ait eu une bonne concordance, un .... tion des stratégies thérapeutiques, dans l'espoir que des recherches futures améliorent les ...

Social Identity Simulation System (SISTEM)

Science.gov (United States)

2014-03-31

Report Individuation Individuation refers to when an individual attempts to preserve self-esteem by psychologically separating oneself from a...its expected costs. The following subsections describe various strategies of social identity entrepreneurship in more detail. Calling for...Haslam, S. A., & Reicher, S. (2007). Identity Entrepreneurship and the consequences of identity failure: the dynamics of leadership in the BBC prison

Analysis of Logistics Support via Acquisition and Cross-Servicing Agreements and Contracted Support

Science.gov (United States)

2017-12-01

Automated Tracking and Reporting System AIT Accountability , Integrity, and Transparency AO Area of Operation AT&L Acquisition, Technology, and... Accountability Office HNS Host Nation Support xvi ID Indefinite Delivery IQ Indefinite Quantity JOPES Joint Operations Planning and Execution...Three Integrative Pillars USC United States Code USMC United States Marine Corps VAT Value Added Tax xviii THIS PAGE INTENTIONALLY LEFT

Historical Jeroným Mine in Čistá – Underground Experimental Geotechnical Laboratory

Czech Academy of Sciences Publication Activity Database

Kaláb, Zdeněk; Hrubešová, E.; Kořínek, R.; Žůrek, P.; Kukutsch, Radovan

2012-01-01

Roč. 21, č. 1 (2012), s. 54-65 ISSN 1211-0728 R&D Projects: GA ČR GA105/09/0089 Institutional research plan: CEZ:AV0Z3086906 Keywords : Jeroným Mine * geotechnical laboratory * monitoring Subject RIV: DC - Siesmology, Volcanology, Earth Structure http://www.ita-aites.cz/files/tunel/komplet/tunel_1_12.pdf

Rationale, design, and protocol for the prevention of low back pain in the military (POLM trial (NCT00373009

Directory of Open Access Journals (Sweden)

Dugan Jessica L

2007-09-01

Full Text Available Abstract Background There are few effective strategies reported for the primary prevention of low back pain (LBP. Core stabilization exercises targeting the deep abdominal and trunk musculature and psychosocial education programs addressing patient beliefs and coping styles represent the current best evidence for secondary prevention of low back pain. However, these programs have not been widely tested to determine if they are effective at preventing the primary onset and/or severity of LBP. The purpose of this cluster randomized clinical trial is to determine if a combined core stabilization exercise and education program is effective in preventing the onset and/or severity of LBP. The effect of the combined program will be compared to three other standard programs. Methods/Design Consecutive Soldiers participating in advanced individual training (AIT will be screened for eligibility requirements and consented to study participation, as appropriate. Companies of Soldiers will be randomly assigned to receive the following standard prevention programs; a core stabilization exercise program (CSEP alone, a CSEP with a psychosocial education (PSEP, a traditional exercise (TEP, or a TEP with a PSEP. Proximal outcome measures will be assessed at the conclusion of AIT (a 12 week training period and include imaging of deep lumbar musculature using real-time ultrasound imaging and beliefs about LBP by self-report questionnaire. We are hypothesizing that Soldiers receiving the CSEP will have improved thickness of selected deep lumbar musculature (transversus abdominus, multifidi, and erector spinae muscles. We are also hypothesizing that Soldiers receiving the PSEP will have improved beliefs about the management of LBP. After AIT, Soldiers will be followed monthly to measure the distal outcomes of LBP occurrence and severity. This information will be collected during the subsequent 2 years following completion of AIT using a web-based data entry system

Determinación de aminas aromaticas por cromatografia liquida de alta resolución.

OpenAIRE

Gutiérrez Bouzán, Mª Carmen; Crespi Rosell, Martí

1989-01-01

Este trabajo consiste en la puesta a punto del metodo analítico para la determinación por cromatografia liquida de alta resolución (HPLC) de las aminas aromáticas empleadas más frecuentemente en la fabricación de colorantes sulfurosos: m-tolilendiamina, p-fenilendiamina, o-toluidina, p-toluidina, anilina, p-aminofenol, difenilamina, y p-hidroxidifenilamina. La longitud de onda de detección es de 260 nm. El principal objetivo del presente estudio es la consecución de un método de análisis p...

Biofertilizer potential of residual biomass of Akk (alotropis procera (Ait.))

International Nuclear Information System (INIS)

Ahmad, N.

2016-01-01

The biofertilizer potential of residual biomass, derived from two parts that is flowers and leaves of Akk,was investigated in terms of its applications as a substrate for phyto-beneficial bacterial growth and subsequent inorganic phosphate solubilizing agent. The residual biomass was obtained after the extraction of antioxidants from the leaves and flowers of Akk using different solvent systems. The treatment with residual biomass of Akk (RBA) significantly (p<0.05) enhanced the growth of Enterobacter sp. Fs-11 and Rhizobium sp. E-11 as compared to control (without residual biomass). Maximum microbial growth in terms of optical density (0.92-1.22) was observed for residual biomass sample extracted with aqueous acetone against the control (0.58-0.68). On the other hand, maximum phosphate solubilization (589.27-611.32 mu g mL-1) was recorded for aqueous ethanol extracted residual biomass while the minimum (246.31-382.15 micro g) for aqueous acetone extracted residual biomass against the control (576.65 micro g mL-1). The present study revealed that the tested RBA can be explored as an effective bio-inoculant to supplement synthetic inorganic phosphate fertilizers. However, some appropriate in-vitro assays should be conducted to optimize and standardize the quantity and mesh size of residual biomass prior to use in biofertilizer production as carrier material. (author)

The EC-ASEAN COGEN programme

Energy Technology Data Exchange (ETDEWEB)

Pennington, M.; Lacrosse, L. [Asian Institute of Technology (Thailand); Schenkel, Y. [Centre de Recherches Agronomiques (Belgium)

1996-12-31

The EC-ASEAN COGEN Programme is a co-operation programme between the European Commission (EC) and the Association of South East Asian Nations (ASEAN) co-ordinated by the Asian Institute of Technology (AIT), Bangkok, Thailand. Its aim is to accelerate the implementation of proven technologies generating heat and/or power from wood and agroindustrial residues through partnerships between European and ASEAN companies. (orig.)

The EC-ASEAN COGEN programme

Energy Technology Data Exchange (ETDEWEB)

Pennington, M; Lacrosse, L [Asian Institute of Technology (Thailand); Schenkel, Y [Centre de Recherches Agronomiques (Belgium)

1997-12-31

The EC-ASEAN COGEN Programme is a co-operation programme between the European Commission (EC) and the Association of South East Asian Nations (ASEAN) co-ordinated by the Asian Institute of Technology (AIT), Bangkok, Thailand. Its aim is to accelerate the implementation of proven technologies generating heat and/or power from wood and agroindustrial residues through partnerships between European and ASEAN companies. (orig.)

44 Apport du SIG et de la télédétection dans la modélisation spatiale ...

African Journals Online (AJOL)

Unicornis

44. ISSN 1813-548X, http://www.afriquescience.info. Ahmed Nasreddine El FAHCHOUCH et al. Apport du SIG et de la télédétection dans la modélisation spatiale de la susceptibilité aux mouvements de terrain dans la région d'Al Hoceima,. Rif Oriental, Maroc. Ahmed NasreddineEl FAHCHOUCH*, Lahsen AIT BRAHIM, ...

Case report

African Journals Online (AJOL)

raoul

21 août 2010 ... anorexia nervosa are correlated with the amount of weight loss and not with other clinical findings. Am J Clin Pathol. 2002. Oct;118(4):582-8. This article on PubMed. 8. Mokrani N, Bourgeois V, Guernou M, Cobert J, Ait-Mouloud S, Bartoli E, Delcenserie R, Chatelain D. La transformation gélatineuse de la.

Využití kotevních systémů v hlubinných dolech OKR a testování jejich únosnosti

Czech Academy of Sciences Publication Activity Database

Souček, Kamil; Koníček, Petr; Staš, Lubomír; Šňupárek, Richard; Ptáček, Jiří

2012-01-01

Roč. 21, č. 2 (2012), s. 4-10 ISSN 1211-0728 R&D Projects: GA MŠk ED2.1.00/03.0082; GA MV VG20102014034 Institutional research plan: CEZ:AV0Z30860518 Keywords : anchoring systems * underground mines * resistance testing Subject RIV: DH - Mining, incl. Coal Mining http://www.ita-aites.cz/files/tunel/komplet/tunel_2_12.pdf

Yeast Interacting Proteins Database: YNL189W, YLR328W [Yeast Interacting Proteins Database

Lifescience Database Archive (English)

Full Text Available ait as prey (0) YLR328W NMA1 Nicotinic acid mononucleotide adenylyltransferase, involved in pathways... of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways... Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the ...de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways Rows with this prey as prey Rows with th

Piigaste pansionaadimõis / Helju Koger

Index Scriptorium Estoniae

Koger, Helju, 1943-

2007-01-01

Põlvamaal Piigaste mõisa endises häärberis avatud pansionist. Sisekujundaja Irene Sepping, kelle jooniste järgi tegi osa elutubade mööblist Wako Värkstuba. Pargi korrastamise plaanist. Kordategemist ootavad muinsuskaitse all olevad puukuur, sammastega ait-kuivati ja tall-tõllakuur. Lühidalt mõisa ajaloost. Kommenteerivad I. Sepping ja pansioni juhataja Kerti Seeme. 10 vaadet

Tier One Performance Screen Initial Operational Test and Evaluation: 2012 Interim Report

Science.gov (United States)

2013-12-01

challenges and are not afraid to face dangerous situations. Curiosity High scoring individuals are inquisitive and perceptive; they are interested in...rpb) between Soldiers’ predicted probability of recycling during IMT and their actual behavior. AFQT + TAPAS = Multiple correlation (R/rpb) between...AIT Grade Disciplinary Incidents (ALQ) Recycled at Least Once (Admin) Effort & Personal Discipline (PRS) Last APFT Score (ALQ) Working

Taxes sur les cigarettes en Tanzanie | IDRC - International ...

International Development Research Centre (IDRC) Digital Library (Canada)

Taxes sur les cigarettes en Tanzanie. De 2002 à 2007, le tabagisme a connu une hausse de 20 % en Tanzanie, une augmentation qui devrait atteindre 46 % en 2016 si la tendance se maintient. On s'attend à ce que cette hausse du tabagisme ait d'importantes répercussions sur la santé publique et le développement ...

Surgical prophylaxis secundary to cryptogenic stroke or transient ischemic attack in patients with patent foramen ovale Profilaxia cirúrgica secundária do acidente vascular cerebral ou ataque isquêmico transitório de origem indeterminada em pacientes com forame oval persistente

Directory of Open Access Journals (Sweden)

Michele E.A. Guffi

2003-09-01

avoids recurrent stroke.INTRODUÇÃO: A prevenção do acidente vascular cerebral (AVC ou ataque isquêmico transitório (AIT de origem indeterminada recorrente em adultos com forame oval persistente (FOP representa um desafio terapêutico. O tratamento farmacológico antitrombótico é amplamente usado, mas a sua indicação é limitada, devido principalmente às suas importantes complicações. OBJETIVO: Demonstrar a eficácia da atriosseptorrafia como profilaxia secundária do AVC ou AIT de origem indeterminada em pacientes com FOP. MÉTODO: Foram estudados 47 pacientes, sendo 31 homens e 16 mulheres com eventos isquêmicos cerebrais. Todos foram submetidos a fechamento cirúrgico direto do FOP. A idade media foi de 40 anos. Não foi achada causa concomitante do AVC ou AIT após investigações, as quais incluíram testes de coagulação sanguínea, ecocardiografia transesofágica de contraste (ETE, ultra-sonografia doppler transcraniana e extracraniana (UDT, monitorização eletrocardiográfica de 24 horas, ressonância magnética cerebral (RMC e tomografia axial computadorizada (TAC. Os critérios para indicação cirúrgica foram pelo menos dois dos seguintes eventos: aneurisma do septo interatrial, infartos cerebrais múltiplos, eventos cerebrais múltiplos e história de manobra de Valsalva antes do AVC ou AIT. RESULTADOS: Não ocorreram complicações durante ou após as operações. Quatro pacientes apresentaram arritmia transitória algumas horas após a operação, sem fibrilação atrial, nem instabilidade hemodinâmica ou embolismo. Todos os pacientes sobreviveram em classe I (NYHA e durante seguimento médio de 36 meses nenhum paciente apresentou recorrência do AVC ou AIT. Todos os pacientes foram submetidos prospectivamente a RMC e ETE de contraste com simultânea UDT. Apenas um paciente apresentou desvio residual direita-esquerda, menor do que o desvio pré-operatório, porém sem lesões na RMC. CONCLUSÃO: A atriosseptorrafia em pacientes com suspeita

Resource communication: ApkFor©, an Android Open-Source Project for research and technology transfer in forest management

Directory of Open Access Journals (Sweden)

Fernando Pérez-Rodríguez

2018-01-01

Full Text Available Aim of the study: To introduce and describe ApkFor©, an Android Open-Source Project to generate basic mobile applications to transfer forest growth and yield models for even-aged stands. Material and methods: ApkFor© was developed in Android Studio using Java and XML languages integrating  transition functions for dominant height and basal area, equations of tree and stand volume and structural models. The project was applied and validated for Pinus pinaster Ait. stands in Northeastern Portugal. Main results: ApkFor© is an Open-Source project freely available from the Source Force repository: https://sourceforge.net/projects/apkfor/, licensed under the GNU General Public License version 3.0 (GPLv3. Research highlights: This project has been designed and created to provide the code and promote its re-use and modification to develop simple growth and yield mobile applications in Android, and with it to transfer research results of forest modelling to forest managers. Moreover, an example of application of the compiled code is provided using the models of Pinus pinaster Ait. previously validated for the Northeastern Region of Portugal.

Influence of Advanced Injection Timing and Fuel Additive on Combustion, Performance, and Emission Characteristics of a DI Diesel Engine Running on Plastic Pyrolysis Oil

Directory of Open Access Journals (Sweden)

Ioannis Kalargaris

2017-01-01

Full Text Available This paper presents the investigation of engine optimisation when plastic pyrolysis oil (PPO is used as the primary fuel of a direct injection diesel engine. Our previous investigation revealed that PPO is a promising fuel; however the results suggested that control parameters should be optimised in order to obtain a better engine performance. In the present work, the injection timing was advanced, and fuel additives were utilised to overcome the issues experienced in the previous work. In addition, spray characteristics of PPO were investigated in comparison with diesel to provide in-depth understanding of the engine behaviour. The experimental results on advanced injection timing (AIT showed reduced brake thermal efficiency and increased carbon monoxide, unburned hydrocarbons, and nitrogen oxides emissions in comparison to standard injection timing. On the other hand, the addition of fuel additive resulted in higher engine efficiency and lower exhaust emissions. Finally, the spray tests revealed that the spray tip penetration for PPO is faster than diesel. The results suggested that AIT is not a preferable option while fuel additive is a promising solution for long-term use of PPO in diesel engines.

Recombinant allergy vaccines based on allergen-derived B cell epitopes.

Science.gov (United States)

Valenta, Rudolf; Campana, Raffaela; Niederberger, Verena

2017-09-01

Immunoglobulin E (IgE)-associated allergy is the most common immunologically-mediated hypersensitivity disease. It affects more than 25% of the population. In IgE-sensitized subjects, allergen encounter can causes a variety of symptoms ranging from hayfever (allergic rhinoconjunctivitis) to asthma, skin inflammation, food allergy and severe life-threatening anaphylactic shock. Allergen-specific immunotherapy (AIT) is based on vaccination with the disease-causing allergens. AIT is an extremely effective, causative and disease-modifying treatment. However, administration of natural allergens can cause severe side effects and the quality of natural allergen extracts limits its application. Research in the field of molecular allergen characterization has allowed deciphering the molecular structures of the disease-causing allergens and it has become possible to engineer novel molecular allergy vaccines which precisely target the mechanisms of the allergic immune response and even appear suitable for prophylactic allergy vaccination. Here we discuss recombinant allergy vaccines which are based on allergen-derived B cell epitopes regarding their molecular and immunological properties and review the results obtained in clinical studies with this new type of allergy vaccines. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Magical Landscapes and Designed Cities

DEFF Research Database (Denmark)

Raahauge, Kirsten Marie

2008-01-01

with “something special,” a feel-good, (almost spiritual) healing power (just moments away from the bustling city). In Melanesia, such a spiritual force goes by the name of “mana”. Århus’ mana landscapes are only invested with this huge, floating quality because they are near the city. Furthermore, they are seen...... from the point of view of the city, where order, design, planning and commerce are important cityscape qualities. The article deals with the way in which these two parts of the city, landscape and brandscape are complementary parts of the city-web. Analytical points made by Mauss, Lévi......-Strauss and Greimas are discussed in connection with the empirical setting of the city of Århus...

Et bedre image

DEFF Research Database (Denmark)

Vestergaard, Hedvig; Haagerup, Christian Deichmann

2010-01-01

Pjecen sammenfatter erfaringer og råd om, hvordan man kan tage fat på at forbedre et boligområdes image. Det er erfaringer og råd som aktører og ledere fra Bispehaven i Århus Kommune, Vejleåparken i Ishøj Kommune og Tingbjerg i Københavns Kommune gerne vil give videre til andre, der skal i gang med...... imageforbedrende indsatser. De tre områder har arbejdet på at forbedre omdømmet og få et bedre image indadtil og udadtil i forbindelse med større renoveringsindsatser i perioden 2002-2009. Hertil kommer optimering af organisationen og organisationskulturen for at nå bedre resultater. Indsatserne i områderne viser...

Engineering laccases: in search for novel catalysts.

Science.gov (United States)

Robert, Viviane; Mekmouche, Yasmina; Pailley, Pierre R; Tron, Thierry

2011-04-01

Laccases (p-diphenol oxidase, EC 1.10.3.2) are blue multicopper oxidases that catalyze the reduction of dioxygen to water, with a concomitant oxidation of small organic substrates. Since the description at the end of the nineteenth century of a factor catalyzing the rapid hardening of the latex of the Japanese lacquer trees (Rhus sp.) exposed to air laccases from different origins (plants, fungi bacteria) have been continuously discovered and extensively studied. Nowadays, molecular evolution and other powerful protein modification techniques offer possibilities to develop tailored laccases for a wide array of applications including drug synthesis, biosensors or biofuel cells. Here, we give an overview on strategies and results of our laboratory in the design of new biocatalysts based on laccases.

Antioxidant properties, physico-chemical characteristics and proximate composition of five wild fruits of Manipur, India.

Science.gov (United States)

Sharma, Ph Baleshwor; Handique, Pratap Jyoti; Devi, Huidrom Sunitibala

2015-02-01

Antioxidant properties, physico-chemical characteristics and proximate composition of five wild fruits viz., Garcinia pedunculata, Garcinia xanthochymus, Docynia indica, Rhus semialata and Averrhoa carambola grown in Manipur, India were presented in the current study. The order of the antioxidant activity and reducing power of the fruit samples was found as R. semialata > D. indica > G. xanthochymus > A. carambola > G. pedunculata. Good correlation coefficient (R(2) > 0.99) was found among the three methods applied to determine antioxidant activity. Total phenolic content was positively correlated (R(2) = 0.960) with the antioxidant activity however, total flavonoid content was not positively correlated with the antioxidant activity. Physico-chemical and proximate composition of these fruits is documented for the first time.

コンクリート再生骨材の諸性質と再生骨材使用コンクリートの強度・耐久性に関する研究

OpenAIRE

岩月, 栄治; 木村, 由香; 森野, 奎二

2002-01-01

Properties of recycled aggregates made of concrete, and strength and durability of concrete using the recycled aggregates are clarified in this study. In the experiment, three kinds of recycled aggregates were used, namely, primary recycled aggregate (recycled aggregate produced crushing concrete specimens made in laboratory), secondary recycled aggregate (marketed recycled aggregate) and AIT recycled aggregate (recycled aggregate produced crushing debris obtained from the demolished concrete...

Révision du genre Digitaria Haller (Poaceae) au Sénégal ...

African Journals Online (AJOL)

Le genre Digitaria Haller (Poaceae) constitue l'un des genres les plus diversifiés des Poaceae du Sénégal avec 19 espèces. Bien qu'il y ait une monographie mondiale du genre, la détermination des espèces reste difficile et repose essentiellement sur les caractères de l'appareil reproducteur. Ce travail, qui est une ...

Turkiye’de Vergi Gelirlerinin Oynakligina Dair Bir Analiz

OpenAIRE

Tuba Ozsevinc; Erdal Yilmaz

2014-01-01

[TR] Vergi gelirlerinin oynakliginin dusuk olmasi, butce planlarini kolaylastirici bir role sahiptir. Bu calismada, degisim katsayisi ve vergi geliri istikrar katsayisi kullanilarak, Turkiye’de vergi gelirlerinin istikrarli olup olmadigi ortaya koyulmaya calisilmistir. Bu nedenle, 2007-2013 yillarina ait vergi gelirleri ele alinmistir. Calismanin sonuclari, Turkiye’de goreli en istikrarli vergi gelirinin, dolaysiz vergilerin en onemli bileseni olan gelir ve kazanc uzerinden alinan vergiler ol...

Les TIC au service du microcrédit : le cas des correspondants ...

International Development Research Centre (IDRC) Digital Library (Canada)

Les TIC au service du microcrédit : le cas des correspondants bancaires au Brésil. Bien qu'il ait été prouvé que les programmes de microfinance constituaient un outil efficace pour lutter contre la pauvreté dans les pays en développement, ils tardent à prendre leur envol en Amérique latine, en particulier au Brésil.

Economics | Page 6 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Une recherche financée par le CRDI a constaté que, bien que le Community Work Programme (CWP) de l'Afrique du Sud ait réduit la violence et la pauvreté dans certaines communautés, ailleurs, il a exacerbé les tensions et amplifié la violence. Read more about Le Community Work Programme à des effets positifs et ...

Zimbabwe Exiles Forum : militer pour la liberté dans la mère patrie ...

International Development Research Centre (IDRC) Digital Library (Canada)

31 janv. 2011 ... Le fait que M. Mugabe ait nommé non pas un, mais deux vice-présidents rend plus complexes les perspectives d'un changement pacifique et laisse entrevoir le spectre d'un chaos politique advenant une passation soudaine des pouvoirs. « Il s'agit là d'un mélange explosif! » dit M. Shumba avec un sourire ...

Taxes sur les cigarettes en Tanzanie | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

On s'attend à ce que cette hausse du tabagisme ait d'importantes répercussions sur la santé publique et le développement économique. Il ressort de l'expérience d'autres régions que le moyen le plus efficace de renverser une telle tendance consiste à augmenter les taxes sur les cigarettes. Toutefois, les responsables des ...

LES PAYS EN TRANSITION

International Development Research Centre (IDRC) Digital Library (Canada)

Cathy Egan

En 2002, une certaine paix sociale avait été rétablie, bien qu'elle fut instable et souvent entachée de violence. Le pays amorçait le ... mieux comprendre comment il recueille et diffuse l'information destinée ... transition) et les technologies de l'information et de la communication (TIC). Les étapes suivantes ont consisté à ...

Résultats de recherche | Page 31 | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Les TIC au service du microcrédit : le cas des correspondants bancaires au Brésil. Bien qu'il ait été prouvé que les programmes de microfinance constituaient un outil efficace pour lutter contre la pauvreté dans les pays en développement, ils tardent à prendre leur envol en Amérique latine, en particulier au Brésil. Projet.

Psychological and Organizational Climate: Dimensions and Relationships

Science.gov (United States)

1977-03-07

liiirilelasst’itcrrel atiotn) have genterallIy beetn low to modierate, vatryitng betweeti .06t antd .35 ( ltams , Valtiit Farrow. & Stolomont 1975; Si-hneider...owever , was5 11111i dilr’c tl viiettrh Ii z al aIt hough~l mos1t StuitIes 14110 r tpora t’ll mv11 or mtore 1 c~ldtrsh ip ditiv101 isi. For exam ~le i

2682-IJBCS-Article-Serge Samandoulougou

African Journals Online (AJOL)

hp

poultry-science-lines-of-xNA.html. Moula N, Antoine-Moussiaux N, Ait Kaki A,. Farnir F, Leroy P. 2012. Comparaison de la qualité des œufs de la race de poule locale Kabyle et de son croisement avec la souche industrielle. Isa-Brown. 10ème Journées des Sciences. Vétérinaires : ENSV, Alger, Algérie. Mourad M, Bah AS, ...

Une Etude Comparée de L'oralité et de L'écriture Dans La ...

African Journals Online (AJOL)

oralité ait existé pendant longtemps dans la société traditionnelle africaine. La raison est qu'il n'existe plus une société traditionnelle à l'état pur. La plupart des membres de cette société ont fréquenté l'école de type européen, ils ont séjourné en ...

Une souplesse au niveau des droits de propriété intellectuelle ...

International Development Research Centre (IDRC) Digital Library (Canada)

27 avr. 2016 ... Leur étude a englobé les secteurs de la musique, de la maroquinerie, du design textile, du cacao, du café, des pièces d'automobile, de la médecine traditionnelle, de l'édition, des biocarburants et de la recherche universitaire. Conclusion : pour qu'il y ait innovation en Afrique, il faut trouver un équilibre ...

Location and Description of Transects for Ecological Studies in Floodplain Forests of the Lower Suwannee River, Florida

Science.gov (United States)

2002-01-01

Level Datum of 1929. Horizontal datum: In this report, horizontal coordinate information is referenced to the North American Datum of 1927 (NAD27...ileopa Ilex opaca Ait. var. opaca American holly junsil Juniperus silicicola (Small) Bailey 1 southern red cedar liqsty Liquidambar styraciflua L...swamp gum nyssyl Nyssa sylvatica Marsh.1 blackgum ostvir Ostrya virginiana (Mill.) K. Koch eastern hophornbeam perpal Persea palustris (Raf.) Sarg

Operationalizing Air-Sea Battle in the Pacific

Science.gov (United States)

2015-02-01

Joumall 25 \\/ FEATURE Ballard, Harysch, Cole, & Hall Operationalizing Ait’-Sea Battle in the Pacific tribes and nomadic marauders such as the...communications in general, the former focuses on the digital data links between different platforms. The original CSBA operational con- cept touches on this...very capable fourth-generation fighters; and it has fielded layers of upgraded and double- digit surface-to-air missile systems and antiaircraft