WorldWideScience

Sample records for rev annual status

  1. Investigations of migratory birds during operation of Horns Rev offshore wind farm. Annual status report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Hounisen, J.P. [NERI, Dept. of Wildlife Ecology and Biodiversity, Roskilde (Denmark)

    2005-07-01

    The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. The study focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging bird species. The study was based on data from spring 2004. The Horns Rev area lies in a region known to be of importance for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

  2. Investigations of migratory birds during operation of Horns Rev offshore wind farm. Annual status report 2004

    International Nuclear Information System (INIS)

    Kjaer Christensen, T.; Hounisen, J.P.

    2005-01-01

    The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. The study focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging bird species. The study was based on data from spring 2004. The Horns Rev area lies in a region known to be of importance for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

  3. Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.; Pedersen, John

    2004-05-15

    Elsam and Eltra built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm off the Danish west coast. The wind farm is sited 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine was erected in May 2002 and the last wind turbine tower of a total of 80 was in place by August 2002. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production by December 2002. The expected impact of the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind turbine towers and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horns Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site-specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrate was conducted in March 2003 and in September 2003. This report describes the first year results of surveys on hard substrate after the completion of the offshore wind farm at Horns Rev. (au)

  4. Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2001 - 31. December 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-10-15

    As a result of the Danish Government's Energy Plan 21 a target of 5,500 MW wind power is to be erected in Denmark by 2030. 4,000 MW of these are to be placed offshore in special pointed areas with minimal impacts on the environment. In 1998 the Danish Ministry of Environment and Energy ordered two power companies, Elsam and Energi E2, to establish each a demonstration wind farm at one of the five pointed areas. The intention was to follow the environmental impacts from the wind farm and to evaluate the possibility of setting up about 1,500 MW in each area with as little impact on the environment as possible. In 1999 the two power companies were given approval to begin pre-studies of each of the two wind farms and the work on the site construction as well as the environmental impact assessment related hereto was initiated. The authorities made a number of requirements for the EIA surveys according to the EU-directive for preparation of EIA reports. In the summer of 2000 the EIA report with project description was submitted to the authorities and the project was approved in the spring of 2001. During the summer and autumn of 2001 orders were placed for the components for the wind farm, i.e. foundations, towers, wind turbines, cables etc. After having finalised the EIA, monitoring programmes of the wind farms were initiated on basis of the results of the surveys carried out during the EIA. This means that continuous surveys have been implemented for most of the environmental parameters from 1999 and till today. This annual status report for 2001 is to present the results from the annual environmental monitoring programme (the baseline studies) at Horns Rev, which form part of the monitoring programme set up for the Horns Rev project. To get a complete picture of the Danish monitoring programme for the national demonstration wind farm project it is necessary to see the report for Horns Rev and for Roedsand as a whole. The report comprises a description of the wind

  5. Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2001 - 31. December 2001

    International Nuclear Information System (INIS)

    2002-10-01

    As a result of the Danish Government's Energy Plan 21 a target of 5,500 MW wind power is to be erected in Denmark by 2030. 4,000 MW of these are to be placed offshore in special pointed areas with minimal impacts on the environment. In 1998 the Danish Ministry of Environment and Energy ordered two power companies, Elsam and Energi E2, to establish each a demonstration wind farm at one of the five pointed areas. The intention was to follow the environmental impacts from the wind farm and to evaluate the possibility of setting up about 1,500 MW in each area with as little impact on the environment as possible. In 1999 the two power companies were given approval to begin pre-studies of each of the two wind farms and the work on the site construction as well as the environmental impact assessment related hereto was initiated. The authorities made a number of requirements for the EIA surveys according to the EU-directive for preparation of EIA reports. In the summer of 2000 the EIA report with project description was submitted to the authorities and the project was approved in the spring of 2001. During the summer and autumn of 2001 orders were placed for the components for the wind farm, i.e. foundations, towers, wind turbines, cables etc. After having finalised the EIA, monitoring programmes of the wind farms were initiated on basis of the results of the surveys carried out during the EIA. This means that continuous surveys have been implemented for most of the environmental parameters from 1999 and till today. This annual status report for 2001 is to present the results from the annual environmental monitoring programme (the baseline studies) at Horns Rev, which form part of the monitoring programme set up for the Horns Rev project. To get a complete picture of the Danish monitoring programme for the national demonstration wind farm project it is necessary to see the report for Horns Rev and for Roedsand as a whole. The report comprises a description of the wind farm

  6. Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report. 2004

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.; Pedersen, John

    2005-05-15

    Elsam and Eltra have built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm at the Danish west coast. The wind farm is located 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine foundation was in place in March 2002 and the last mono-pile was in place in August 2002 for a total of 80. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production in December 2002. The expected impact from the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind mono-piles and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horn Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrates were initialised in March 2003 with monitoring conducted in September 2003 and March and September 2004. This report describes the results from surveys on hard substrates in 2004. (au)

  7. Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report. 2004

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S B; Pedersen, John

    2005-05-15

    Elsam and Eltra have built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm at the Danish west coast. The wind farm is located 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine foundation was in place in March 2002 and the last mono-pile was in place in August 2002 for a total of 80. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production in December 2002. The expected impact from the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind mono-piles and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horn Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrates were initialised in March 2003 with monitoring conducted in September 2003 and March and September 2004. This report describes the results from surveys on hard substrates in 2004. (au)

  8. Bird numbers and distributions in the Horns Rev offshore wind farm area. Annual status report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Krag Petersen, I.

    2005-07-01

    This report presents data from four aerial surveys of birds in the Horns Rev wind farm area in 2004. Three surveys from the winter and spring of 2004 are thoroughly reported here. The fourth survey of 9 September 2004 is reported in general terms, but not included in presentations of distribution and effect analyses of the wind farm. Data from this survey will be thoroughly dealt with in a future report. Including the four surveys of 2004, a total of 29 surveys have been performed in that area since August 1999. (au)

  9. Infauna monitoring Horns Rev offshore wind farm. Annual status report 2003

    International Nuclear Information System (INIS)

    Bech, M.; Leonhars, S.B.; Pedersen, John

    2004-05-01

    ELSAM and ELTRA have established an offshore wind farm with an output of 160 MW in the waters of Horns Rev 1420 km off Blaevands Huk, which is the most westerly point of Denmark. The first phase of construction of the wind farm started in spring 2002. Before the construction activities took place, a baseline description of the benthos was conducted as a part of an environmental monitoring programme for the establishment of the Horns Rev Offshore Wind Farm. The baseline surveys for the present monitoring programme were conducted in the wind farm area on three occasions: spring 1999, spring 2001 and September 2001. In designated reference areas, surveys were conducted in spring 1999 and September 2001. The reference areas in 1999 and September 2001 were placed at two different geographical locations because the survey in September 2001 was planned to be a part of a fish monitoring programme. A comparison between the baseline study in spring 2001 and the baseline study in autumn 2001 clearly revealed that the biomass of most species increased considerably from spring to September. Despite the increase in biomass, the overall distribution of the species and their relative abundance did not change. In order to use the baseline data to investigate a possible impact after the construction of the wind farm, it was essential to arrange the monitoring programme either in spring or in September 2003, because the baseline studies were conducted in these periods. The monitoring programme was conducted in September 2003 after the wind farm had become operational, parallel with the survey on hard bottom substrates. The impacts of the wind farm on the benthic fauna (infauna) in the area were mainly expected to be due to the alteration of the local currents. As the changes in the currents are only minor, impacts on the water chemistry and on the benthic fauna resulting from hydrodynamic causes were expected to be limited or non-existent. The main objective of the present monitoring

  10. Infauna monitoring Horns Rev offshore wind farm. Annual status report 2004

    International Nuclear Information System (INIS)

    Bech, M.; Frederiksen, R.; Pedersen, John; Leonhard, S.B.

    2005-04-01

    A total of 40 species were identified from the surveys in the Horns Rev area in September 2004 while 42 species were identified in 2003 and 47 species in September 2001. The decline in the number of species occurred both inside the wind farm and reference areas, which indicates that the decline could be a combination of changes in sediment characteristics and natural variation rather than an effect from the establishment of the wind farm. More species were not associated with the hard substrate at the turbine sites in 2004 compared to 2003, while in 2001, more species were associated with fine-grained sand. The median sediment grain size increased from 2001 to 2003 to 2004, which suggests that the velocity of the current increased, but modelling calculations on current speed predicted a 2% reduction in the wind farm area and up to a 15% reduction very close to the scour protection. These results agreed with the grain sizes found at the stations 5, 25 and 100 metres from the scour protection. At most stations, the medium grain size was 5 metres lower from the scour protection compared with the station 100 metres from the scour protection, which indicates that the velocity of the current was lower close to the scour protection. No significant impact on the infauna in the wind farm area was detectable concerning distance-related effects. Though general reductions in the population size of some of the character species in the surveyed areas might be related to changes in the sediment structure, the infauna community at Horns Rev showed no obvious sign of stress response as a consequence of possible impact from construction and operating activities. New species were observed in 2003 and 2004 and some of these might be a result of sediment characteristics, less predation or natural variation. The recording of other species might be a result of the introduction of hard bottom habitants in the wind farm area. The density of the most abundant bivalves and bristle worms was

  11. Infauna monitoring Horns Rev offshore wind farm. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Bech, M.; Leonhars, S.B.; Pedersen, John

    2004-05-15

    ELSAM and ELTRA have established an offshore wind farm with an output of 160 MW in the waters of Horns Rev 1420 km off Blaevands Huk, which is the most westerly point of Denmark. The first phase of construction of the wind farm started in spring 2002. Before the construction activities took place, a baseline description of the benthos was conducted as a part of an environmental monitoring programme for the establishment of the Horns Rev Offshore Wind Farm. The baseline surveys for the present monitoring programme were conducted in the wind farm area on three occasions: spring 1999, spring 2001 and September 2001. In designated reference areas, surveys were conducted in spring 1999 and September 2001. The reference areas in 1999 and September 2001 were placed at two different geographical locations because the survey in September 2001 was planned to be a part of a fish monitoring programme. A comparison between the baseline study in spring 2001 and the baseline study in autumn 2001 clearly revealed that the biomass of most species increased considerably from spring to September. Despite the increase in biomass, the overall distribution of the species and their relative abundance did not change. In order to use the baseline data to investigate a possible impact after the construction of the wind farm, it was essential to arrange the monitoring programme either in spring or in September 2003, because the baseline studies were conducted in these periods. The monitoring programme was conducted in September 2003 after the wind farm had become operational, parallel with the survey on hard bottom substrates. The impacts of the wind farm on the benthic fauna (infauna) in the area were mainly expected to be due to the alteration of the local currents. As the changes in the currents are only minor, impacts on the water chemistry and on the benthic fauna resulting from hydrodynamic causes were expected to be limited or non-existent. The main objective of the present monitoring

  12. Bird numbers and distribution in the Horns Rev offshore wind farm area. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This report presents data from six aerial surveys of birds in the Horns Rev wind farm area in 2003. Including 16 surveys conducted before construction of the wind farm started and three during the construction phase, a total of 25 surveys have been performed in the area since August 1999. Up until August 2002 the study area was surveyed from 26 north-south oriented, parallel transect lines. After that time four short transects were added eastwards from the previously easternmost transect. From August 2002 slight adjustments to the transect lines in the wind farm area had to be made in order to avoid collision, as survey altitude was 76 m and wind turbines are 110 m to highest wing tip. The six surveys in 2003 were performed on 13 February, 16 March, 23 April, 5 September, 4 and 30 December. The operational phase of the wind farm commenced in 2002. Hence the six surveys from 2003 are all considered post-construction data sets. A preliminary evaluation of the potential impact of the wind turbines on bird distributions has been carried out by comparison of these data to those from the 16 pre-construction surveys. (au)

  13. Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2002 - 31. December 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-04-15

    This annual report, which is a baseline and/or an evaluation of the effects of construction phase, is based on extracts from our consultants' annual reports. These annual reports are individual reports, in which surveys have been made during the year 2002 and reported in the beginning of 2003. Detailed information on methods, programmes and conclusions can be found in these reports. In general it should be noted that apparently the construction phase has not had any unintended effects on the parameters surveyed. Therefore we can also conclude that the protective measures established by Elsam, especially scaring devices/ramp-ups for marine mammals, have had the intended effect. Especially interesting parameters that should be mentioned are: Birds: The seagull species 'Herring Gulls' was found to be attracted by the wind farm during the construction period. The number of Divers has decreased, however statistically this decrease is very small as very few Divers have been observed under the baseline. Porpoises: Porpoises generally stayed away from the construction area during pile driving. This effect was intended and scaring devices were deployed in order to ensure that the animals' hearing was not permanently damaged. Seals: The purpose of the programme has not been to show statistically significant effects during the construction phase. The purpose was to get an idea of their behaviour during the construction phase within the wind farm as well as on the reef. It has been concluded that Horns Rev is not used as a foraging area as much as expected. It is used as transit area for bigger foraging sites in the North Sea. Sand eels and Spisula: A baseline survey of sand eels within the wind farm area has been made. It is shown that sand eels are found in the wind farm area. Spisula have been found in the wind farm area but not in the amount expected. Hard substrate habitat: Baseline surveys on fish have been made during the spring of 2002. The

  14. Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2002 - 31. December 2002

    International Nuclear Information System (INIS)

    2003-04-01

    This annual report, which is a baseline and/or an evaluation of the effects of construction phase, is based on extracts from our consultants' annual reports. These annual reports are individual reports, in which surveys have been made during the year 2002 and reported in the beginning of 2003. Detailed information on methods, programmes and conclusions can be found in these reports. In general it should be noted that apparently the construction phase has not had any unintended effects on the parameters surveyed. Therefore we can also conclude that the protective measures established by Elsam, especially scaring devices/ramp-ups for marine mammals, have had the intended effect. Especially interesting parameters that should be mentioned are: Birds: The seagull species 'Herring Gulls' was found to be attracted by the wind farm during the construction period. The number of Divers has decreased, however statistically this decrease is very small as very few Divers have been observed under the baseline. Porpoises: Porpoises generally stayed away from the construction area during pile driving. This effect was intended and scaring devices were deployed in order to ensure that the animals' hearing was not permanently damaged. Seals: The purpose of the programme has not been to show statistically significant effects during the construction phase. The purpose was to get an idea of their behaviour during the construction phase within the wind farm as well as on the reef. It has been concluded that Horns Rev is not used as a foraging area as much as expected. It is used as transit area for bigger foraging sites in the North Sea. Sand eels and Spisula: A baseline survey of sand eels within the wind farm area has been made. It is shown that sand eels are found in the wind farm area. Spisula have been found in the wind farm area but not in the amount expected. Hard substrate habitat: Baseline surveys on fish have been made during the spring of 2002. The programme regarding the

  15. Elsam. Offshore Wind Turbines. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2004 - 31. December 2004

    International Nuclear Information System (INIS)

    2005-07-01

    In 2001, the former Ministry of the Environment and Energy granted Elsam A/S and Eltra A.m.b.A. approval to establish a wind farm capable of producing 160 MW of electric power, at Horns Rev, west of Blaevandshuk at the west coast of Jutland. According to the conditions of the approval, Elsam and Eltra were required to monitor the environmental effects of the wind farm by performing monitoring before, during and after construction of the wind farm. The environmental monitoring programme is financed through Public Service Obligation (PSO). Analogue to the Horns Rev wind farm another offshore demonstrational wind farm was established in the Baltic sea south of Lolland by Energi E2 the Nysted 165 MW offshore wind farm. To coordinate the environmental monitoring at the two demonstration wind farms at Nysted and Horns Rev within the framework of the approved budget, the Environmental Group of Danish Offshore Wind Farm Demonstration Projects was set up. The group consists of representatives from the Danish Forest and Nature Agency, the Danish Energy Authority, Elsam and Energi E2. The Environmental Group initiates, monitors and evaluates the environmental programmes continuously with respect to possible improvements and intensifications to ensure that the design of the individual programmes is optimal. After evaluation, the monitoring programmes are proposed by the Environmental Group and carried out after final approval by the Danish Energy Authority. The Environmental Group considers if there is reason to adjust the issues and priorities of the programmes based on previous experience or other inputs eg from the international expert panel, IAPEME (International Advisory Panel of Experts on Marine Ecology). IAPEME evaluates the environmental monitoring programmes and makes valuable suggestions and recommendations to the Environmental Group. The programmes have concentrated on the monitoring of possible impacts before, during and after construction to investigate and

  16. Elsam. Offshore Wind Turbines. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2004 - 31. December 2004

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-15

    In 2001, the former Ministry of the Environment and Energy granted Elsam A/S and Eltra A.m.b.A. approval to establish a wind farm capable of producing 160 MW of electric power, at Horns Rev, west of Blaevandshuk at the west coast of Jutland. According to the conditions of the approval, Elsam and Eltra were required to monitor the environmental effects of the wind farm by performing monitoring before, during and after construction of the wind farm. The environmental monitoring programme is financed through Public Service Obligation (PSO). Analogue to the Horns Rev wind farm another offshore demonstrational wind farm was established in the Baltic sea south of Lolland by Energi E2 the Nysted 165 MW offshore wind farm. To coordinate the environmental monitoring at the two demonstration wind farms at Nysted and Horns Rev within the framework of the approved budget, the Environmental Group of Danish Offshore Wind Farm Demonstration Projects was set up. The group consists of representatives from the Danish Forest and Nature Agency, the Danish Energy Authority, Elsam and Energi E2. The Environmental Group initiates, monitors and evaluates the environmental programmes continuously with respect to possible improvements and intensifications to ensure that the design of the individual programmes is optimal. After evaluation, the monitoring programmes are proposed by the Environmental Group and carried out after final approval by the Danish Energy Authority. The Environmental Group considers if there is reason to adjust the issues and priorities of the programmes based on previous experience or other inputs eg from the international expert panel, IAPEME (International Advisory Panel of Experts on Marine Ecology). IAPEME evaluates the environmental monitoring programmes and makes valuable suggestions and recommendations to the Environmental Group. The programmes have concentrated on the monitoring of possible impacts before, during and after construction to investigate and

  17. Visual and radar observations of birds in relation to collision risk at the Horns Rev offshore wind farm. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Hounisen, J.P.; Clausager, I.; Krag Petersen, I.

    2004-07-01

    The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. In 2003 the studies focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging species. The Horns Rev area lies in a region known to be important for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

  18. Annual Hanford Site Environmental Permitting Status Report

    International Nuclear Information System (INIS)

    HOMAN, N.A.

    2000-01-01

    The information contained in, and/or referenced in, this Annual Hanford Site Environmental Permitting Status Report addresses Permit Condition II.W (Other Permits and/or Approvals) of the Dangerous Waste Portion of the Resource Conservation and Recovery Act Permit for the Treatment, Storage, and Disposal of Dangerous Waste, issued by the Washington State Department of Ecology (WA7890008967). Condition II.W specifies that the Permittees are responsible for obtaining all other applicable federal, state, and local permits authorizing the development and operation of the Hanford Facility. This status report also addresses Permit Condition I.E.22, as interpreted in Section 12.1.25 of the Hanford Facility Dangerous Waste Permit Application, General Information Portion (DOE/RL-91-28, Rev. 4), that states this report will be prepared annually and a copy of this report will be placed in the Facility Operating Record, General Information file by October 1 of each year

  19. Infauna monitoring Horns Rev offshore wind farm. Annual state report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Bech, M.; Frederiksen, R.; Pedersen, John; Leonhard, S.B.

    2005-04-15

    A total of 40 species were identified from the surveys in the Horns Rev area in September 2004 while 42 species were identified in 2003 and 47 species in September 2001. The decline in the number of species occurred both inside the wind farm and reference areas, which indicates that the decline could be a combination of changes in sediment characteristics and natural variation rather than an effect from the establishment of the wind farm. More species were not associated with the hard substrate at the turbine sites in 2004 compared to 2003, while in 2001, more species were associated with fine-grained sand. The median sediment grain size increased from 2001 to 2003 to 2004, which suggests that the velocity of the current increased, but modelling calculations on current speed predicted a 2% reduction in the wind farm area and up to a 15% reduction very close to the scour protection. These results agreed with the grain sizes found at the stations 5, 25 and 100 metres from the scour protection. At most stations, the medium grain size was 5 metres lower from the scour protection compared with the station 100 metres from the scour protection, which indicates that the velocity of the current was lower close to the scour protection. No significant impact on the infauna in the wind farm area was detectable concerning distance-related effects. Though general reductions in the population size of some of the character species in the surveyed areas might be related to changes in the sediment structure, the infauna community at Horns Rev showed no obvious sign of stress response as a consequence of possible impact from construction and operating activities. New species were observed in 2003 and 2004 and some of these might be a result of sediment characteristics, less predation or natural variation. The recording of other species might be a result of the introduction of hard bottom habitants in the wind farm area. The density of the most abundant bivalves and bristle worms was

  20. Status report of seabird surveys at Horns Rev, 2000-2001

    International Nuclear Information System (INIS)

    Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I.

    2002-01-01

    The present report presents the results of three bird surveys conducted in the Horns Rev area during the second half of 2001. Due to poor weather conditions in December 2001, the last survey was, however, performed on 7 January 2002. The surveys are part of the base-line investigations of birds performed in relation to the proposed construction of an offshore wind farm at Horns Rev in the Danish part of the North Sea ca 14 km southwest of Blaevandshuk. The results of the surveys during August 2001 - January 2002 are presented together with the results obtained during the period August 2000 - April 2001, and are also compared to results obtained during the period August 1999 - April 2000. Based on the distribution of the most abundant bird species recorded during 16 aerial surveys performed during August 1999 - January 2002, there were no indications that the wind farm area was of any particular importance to the birds' exploitation of the Horns Rev area. Fish-eating species like divers, gannet, terns, auks and gulls generally showed scattered and variable distributions, mainly occurring in the areas north and south of Horns Rev, and with low numbers on the reef proper and within the planned wind farm area. The distribution of benthic foraging species, eider and common Scoter, showed that they mainly exploited the coastal parts of the area off Blaevandshuk and Skallingen, although common scoter was found in relatively high numbers on the southeast slopes of the Horns Rev and within the wind farm area in the April 2001 survey. Common scoters occurred in very high numbers in January 2002. This was probably related to increased immigration of birds from the inner Danish waters during a cold period in late December 2001. Preference analyses of bird exploitation of the Horns Rev area showed that if the birds completely avoid the wind farm area after erection of the wind turbines, this will affect less than 1% of the various species, except divers where 1.58% will be

  1. Reactor incident status 1981 annual report

    International Nuclear Information System (INIS)

    Kiser, S.H.

    1982-01-01

    Reactor Incident followup action is summarized through periodic status reports. This annual report summarizes action taken or anticipated for Reactor Incidents through December 1981. Incidents for which action has been completed, have been deleted from the report. Quarterly addende will update the report by tabulating incidents for each three month period through the coming year. The report consists of a part for the P, K, and C Reactors. Each reactor part is divided into three sections: Further Technical Analysis or Followup Needed; Funding and/or Implementation Needed; and No Further Technical Analysis Anticipated

  2. Annual Hanford Site Environmental Permitting status report

    International Nuclear Information System (INIS)

    SONNICHSEN, J.C.

    1999-01-01

    The information contained in, and/or referenced in, this Annual Hanford Site Environmental Permitting Status Report addresses Permit Condition II.W (Other Permits and/or Approvals) of the Dangerous Waste Portion of the Resource Conservation and Recovery Act Permit for the Treatment, Storage, and Disposal of Dangerous Waste, issued by the Washington State Department of Ecology (WA7890008967). Condition II.W specifies that the Permittees are responsible for obtaining all other applicable federal, state, and local permits authorizing the development and operation of the Hanford Facility. Condition II.W further specifies that the Permittees are to use their best efforts to obtain such permits. For the purposes of this Permit Condition, ''best efforts'' mean submittal of documentation and/or approval(s) in accordance with schedules specified in applicable regulations, or as determined through negotiations with the applicable regulatory agencies

  3. Annual Hanford Site environmental permitting status report

    International Nuclear Information System (INIS)

    Sonnichsen, J.C.

    1998-01-01

    The information contained and/or referenced in this Annual Hanford Site Environmental Permitting Status Report (Status Report) addresses the State Environmental Policy Act (SEPA) of 1971 and Condition II.W. of the Resource Conservation and Recovery Act (RCRA) of 1976 Permit, Dangerous Waste Portion (DW Portion). Condition II.W. of the RCRA Permit specifies the Permittees are responsible for all other applicable federal, state, and local permits for the development and operation of the Hanford Facility. Condition II.W. of the RCRA Permit specifies that the Permittees are to use their best efforts to obtain such permits. For the purposes of permit condition, 'best efforts' means submittal of documentation and/or approval(s) in accordance with schedules specified in applicable regulations, or as determined through negotiations with the applicable regulatory agencies. This Status Report includes information on all existing and anticipated environmental permitting. Environmental permitting required by RCRA, the Hazardous and Solid Waste Amendments (HSWA) of 1984, and non-RCRA permitting (solid waste handling, Clean Air Act Amendments of 1990, Clean Water Act Amendments of 1987, Washington State waste discharge, and onsite sewage system) is addressed. Information on RCRA and non-RCRA is current as of July 31, 1998. For the purposes of RCRA and the State of Washington Hazardous Waste Management Act of 1976 [as administered through the Dangerous Waste Regulations, Washington Active Code (WAC) 173-303], the Hanford Facility is considered a single facility. As such, the Hanford Facility has been issued one US Environmental Protection Agency (EPA)/State Identification Number (WA7890008967). This EPA/State identification number encompasses over 60 treatment, storage, and/or disposal (TSD) units. The Washington State Department of Ecology (Ecology) has been delegated authority by the EPA to administer the RCRA, including mixed waste authority. The RCRA permitting approach for

  4. Annual Status Report (FY2016) Performance Assessment for the Environmental Restoration Disposal Facility

    Energy Technology Data Exchange (ETDEWEB)

    Casbon, M. A. [CH2M HILL Plateau Remediation Company, Richland, WA (United States); Nichols, W. E. [CH2M HILL Plateau Remediation Company, Richland, WA (United States)

    2017-03-15

    DOE O 435.1, Radioactive Waste Management, and DOE M 435.1-1, Radioactive Waste Management Manual, require that a determination of continued adequacy of the performance assessment (PA), composite analysis (CA), and disposal authorization statement (DAS) be made on an annual basis, and it must consider the results of data collection and analysis from research, field studies, and monitoring. Annual summaries of low-level waste (LLW) disposal operations must be prepared with respect to the conclusions and recommendations of the PA and CA, and a determination of the need to revise the PA or CA must be made. The annual summary requirement provides a structured approach for demonstrating the continued adequacy of the PA and CA in demonstrating a reasonable expectation that the performance objectives will be met. This annual summary addresses only the status of the Environmental Restoration Disposal Facility (ERDF) PA (CP-60089, Performance Assessment for the Environmental Restoration Disposal Facility, Hanford Site, Washington, formerly WCH-520 Rev. 1)1. The CA for ERDF is supported by DOE/RL-2016-62, Annual Status Report (FY 2016): Composite Analysis of Low Level Waste Disposal in the Central Plateau at the Hanford Site. The ERDF PA portion of the CA document is found in Section 3.1.4, and the ERDF operations portion is found in Section 3.3.3.2 of that document.

  5. Kozloduy nuclear power plant. Units 1-4. Status of safety assessment activities. Rev. 2

    International Nuclear Information System (INIS)

    1999-01-01

    This paper presents the results of the status of safety assessment activities carried out by the Kozloduy Nuclear Power Plant (KNPP) in order to evaluate the current status of the safety of its reactor units 1-4. The steam supply system of this units is based of the reactor WWER-440/ B-230, which is a PWR of Russian design developed according to the safety standards in force in USSR in late 60-s. Now a days 10 reactor units of this type are in operation in four NPPs. Despite of efforts of the different plants to implement safety improvements measures during first 10-15 years of operation of this type of reactor its major safety problems were not eliminated and were a subject of international concern. The systematic evaluation of the deficiencies of the original design of this type of reactors have been initiated by IAEA in the beginning of 1990 and brought to developing a comprehensive list of safety problems which required urgent implementation of safety measures in all plants. To solve this problems in 1991 KNPP initiated implementation of so called 'short term' safety improvement program, developed with the help of WANO under agreement with Bulgarian Nuclear Safety Authority (BNSA) and consortium RISKAUDIT. The program was based on a stage approach and was foreseen to be implemented by tree stages in very tight time schedule in order to achieve significant and rapid improvements of the level of safety in operation of the units. The Short Tenn Program was implemented between the years 1991 and 1997 thanks of the strong safety commitment of NEK and KNPP staff and the broad international cooperation and financial support. Important part of resources were supplied under PHARE program of CEC, EBRD grant agreement and EDF support. The plant current safety level analysis has been performed using IAEA analytical methodology according to 50-SG-O12 standard 'Periodic safety review of operational nuclear power plants'. The approach and criteria for acceptable safety level

  6. Kozloduy nuclear power plant. Units 1-4. Status of safety improvements. Rev. 2

    International Nuclear Information System (INIS)

    1999-01-01

    operation of the units. The plant current safety level analysis has been performed using IAEA analytical methodology according to 50-SG-O12 standard 'Periodic safety review of operational nuclear power plants'. The approach and criteria for acceptable safety level definition, developed by IAEA and presented in INSAG-8 ' was used for analysis performance. Based on this analysis a set of activities was developed, to ensures further plant operation with the necessary safety level. The measures were combined in a program called Complex program for modernization of units 1-4. The implementation of the program is foreseen for a period of four next fuel cycles and started at the beginning of 1998. In respond to the requirements for the content of this paper a detailed description of the current status of resolving of the safety issues, classified by IAEA in TECDOC 640 is presented. The whole process of safety evaluation, short and long term safety improvements presents in a systematical manner the efforts of the Government of Bulgaria, NEK Ltd and KNPP to operate these units with due respect of their nuclear safety responsibility according to Nuclear Safety Convention signed at Vienna in 1994 and ratified by Bulgarian Parliament in 1995

  7. Hydroacoustic registration of fish abundance of offshore wind farms. Horns Rev offshore wind farm. Annual report 2004.

    Energy Technology Data Exchange (ETDEWEB)

    Hvidt, C.B.; Bruenner, L.; Reier Knudsen, F.

    2005-05-15

    Elsam Engineering AS has approved the implementation of a project concerning the registration of fish communities in Horns Rev Offshore Wind Farm with use of hydroacoustic methods. In a joint effort, Bio/consult as, Carl Bro as and SIMRAD AS have monitored the fish communities at Horns Rev Offshore Wind Farm using a new hydroacoustic methodology. The new hydroacoustic technique combines the use of scientific sonar acoustics with GPS to determine the density, diversity and location of fish. The objectives of this project were to test the possibility of using hydroacoustic techniques as alternative methods to traditional techniques to assess the fish assemblage inhabiting offshore wind farms and to investigate the possible effect from the wind farm and hard bottom substrates (turbine foundations) on fish abundance. The field study was carried out October 9-10, 2004 and consisted of four horizontal hydroacoustic survey transects each covering impact and reference areas. Transects were surveyed in order to achieve identical impact and reference transect pairs concerning environment, topography and time correspondence. The hydroacoustic equipment consisted of a SIMRAD EK60/EY60 echo sounder with a split-beam transducer (Simrad ES 120-4x10) mounted on a pan and tilt unit, a transceiver, a laptop extended with a GPS-receiver and additional large external hard discs. The raw data files from EK60 were converted to echogram files suitable for the post processing application, Sonar5-Pro. The Sonar5-Pro software makes it possible to filter out echo detections from the surface and the bottom, as well as perform cross filter detection. The validity of the results using the hydroacoustic method is high due to the cross filtering and single target tracking technique. From the hydroacoustic results, no or very little effect from the wind farm or from hard bottom substrates was found on the fish densities at Horns Rev Wind Farm at the time of the survey. The execution of the field

  8. 1982 annual status report. Nuclear measurements

    International Nuclear Information System (INIS)

    1983-01-01

    The Nuclear Measurement programme is briefly presented in this status report, it is divided in two main projects, Nuclear Data on the one hand (neutron data, non neutron nuclear data) and Nuclear Reference Materials and Techniques on the other (nuclear reference materials, samples and targets for nuclear measurements, development of reference techniques, study for the production of enriched actinide isotopes)

  9. Horns Rev offshore wind farm. Introducing hard bottom substrate sea bottom and marine biology. Status report 2001

    International Nuclear Information System (INIS)

    Leonhard, S.B.; Pedersen, John

    2002-08-01

    A baseline description of the benthos was carried out in spring and autumn 2001 prior to the construction of an offshore wind farm at Horns Rev, situated approximately 15 km off Blaevands Huk, which is Denmark's most westerly point. The surveys have been conducted as part of an environmental monitoring programme for the introduction of hard bottom substrates in the North Sea. The establishment of a monitoring programme is required according to some environmental guidelines set up by the Danish Energy Agency for offshore wind farms. Because no environmental criteria existed for benthic communities in connection with the construction activities, no power analysis was made prior to the design of the monitoring programme. The monitoring programme established for the benthic infauna is thus somewhat limited and only major changes in the community structure are expected to be detectable. The baseline description for the benthic infauna can also be used for comparison of the stomach contents of fish in a comparative programme. A newly defined reference area may be introduced for the fish programme why sampling in this area was carried out in the autumn 2001. Samples were recovered at a total of 18 stations at 6 wind turbine locations in the wind farm area in June 2001 and at a total of 9 stations at 3 wind turbine locations in September 2001. In September additional sampling was carried out at 5 stations in a designated reference area. At the wind turbine locations sampling was carried out at 3 stations located 5, 25 and 100 m from the edge of the planned scour protection. Samples were analysed for sediment characteristics and for benthic infauna. Only the benthos relating to the macrofauna was investigated during the surveys. (au)

  10. Horns Rev offshore wind farm. Introducing hard bottom substrate sea bottom and marine biology. Status report 2001

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.; Pedersen, John

    2002-08-15

    A baseline description of the benthos was carried out in spring and autumn 2001 prior to the construction of an offshore wind farm at Horns Rev, situated approximately 15 km off Blaevands Huk, which is Denmark's most westerly point. The surveys have been conducted as part of an environmental monitoring programme for the introduction of hard bottom substrates in the North Sea. The establishment of a monitoring programme is required according to some environmental guidelines set up by the Danish Energy Agency for offshore wind farms. Because no environmental criteria existed for benthic communities in connection with the construction activities, no power analysis was made prior to the design of the monitoring programme. The monitoring programme established for the benthic infauna is thus somewhat limited and only major changes in the community structure are expected to be detectable. The baseline description for the benthic infauna can also be used for comparison of the stomach contents of fish in a comparative programme. A newly defined reference area may be introduced for the fish programme why sampling in this area was carried out in the autumn 2001. Samples were recovered at a total of 18 stations at 6 wind turbine locations in the wind farm area in June 2001 and at a total of 9 stations at 3 wind turbine locations in September 2001. In September additional sampling was carried out at 5 stations in a designated reference area. At the wind turbine locations sampling was carried out at 3 stations located 5, 25 and 100 m from the edge of the planned scour protection. Samples were analysed for sediment characteristics and for benthic infauna. Only the benthos relating to the macrofauna was investigated during the surveys. (au)

  11. Horns Rev offshore wind farm. Introducing hard bottom substrate sea bottom and marine biology. Status report 2001

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S B; Pedersen, John

    2002-08-15

    A baseline description of the benthos was carried out in spring and autumn 2001 prior to the construction of an offshore wind farm at Horns Rev, situated approximately 15 km off Blaevands Huk, which is Denmark's most westerly point. The surveys have been conducted as part of an environmental monitoring programme for the introduction of hard bottom substrates in the North Sea. The establishment of a monitoring programme is required according to some environmental guidelines set up by the Danish Energy Agency for offshore wind farms. Because no environmental criteria existed for benthic communities in connection with the construction activities, no power analysis was made prior to the design of the monitoring programme. The monitoring programme established for the benthic infauna is thus somewhat limited and only major changes in the community structure are expected to be detectable. The baseline description for the benthic infauna can also be used for comparison of the stomach contents of fish in a comparative programme. A newly defined reference area may be introduced for the fish programme why sampling in this area was carried out in the autumn 2001. Samples were recovered at a total of 18 stations at 6 wind turbine locations in the wind farm area in June 2001 and at a total of 9 stations at 3 wind turbine locations in September 2001. In September additional sampling was carried out at 5 stations in a designated reference area. At the wind turbine locations sampling was carried out at 3 stations located 5, 25 and 100 m from the edge of the planned scour protection. Samples were analysed for sediment characteristics and for benthic infauna. Only the benthos relating to the macrofauna was investigated during the surveys. (au)

  12. Annual Status Report on Nationally Appropriate Mitigation Actions (NAMAs) 2012

    Energy Technology Data Exchange (ETDEWEB)

    Haensel, G.; Roeser, F.; Hoehne, N. [Ecofys, Utrecht (Netherlands); Van Tilburg, X.; Cameron, L. [ECN Policy Studies, Amsterdam (Netherlands)] (eds.)

    2012-11-15

    The development of Nationally Appropriate Mitigation Actions (NAMAs) has increased significantly over the last few years. The flexibility of the NAMA mechanism is widely regarded as an opportunity to deliver benefits that go far beyond greenhouse gas (GHG) emission reductions. Many developing countries are developing pilot NAMAs that deliver important insights into the challenges of, and opportunities for, NAMA development from a national perspective. A few countries are already a step ahead and experiences gained from pilot NAMA development are feeding into the formulation of national climate change policies in which NAMAs are becoming a key element. To maintain the momentum in NAMA development, clear signs at the international level are needed that developed countries will follow through with their financial commitments made under the Copenhagen Accord. Without this financial support, NAMAs will not be able to realise their full potential and induce transformational change. The Annual Status Report on NAMAs 2012 is a continuation of previously published NAMA Status Reports. The report presents an overview of the state of play of NAMAs and of support activities for NAMA development and implementation. A new feature of the Annual Status Report on NAMAs 2012 is that it is produced as a joint effort by several organizations that are closely involved in analysing and supporting NAMA development processes worldwide. The Annual Status Report on NAMAs 2012 is written by authors from Ecofys, the Energy research Centre of the Netherlands, the Center of Clean Air Policy (CCAP), the World Resources Institute (WRI) and Deutsche Gesellschaft fuer Internationale Zusammenarbeit (GIZ). In the section on 'Selected contributions on NAMAs', each organization discusses a specific topic of interest in relation to NAMA development that is closely related to their current NAMA activities or that is expected to provide 'food for thought' on potential ways forward for

  13. U.S. Renewables Portfolio Standards: 2017 Annual Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Barbose, Galen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2017-07-25

    Berkeley Lab’s annual status report on U.S. renewables portfolio standards (RPS) provides an overview of key trends associated with U.S. state RPS policies. The report, published in slide-deck form, describes recent legislative revisions, key policy design features, compliance with interim targets, past and projected impacts on renewables development, and compliance costs. The 2017 edition of the report presents historical data through year-end 2016 and projections through 2030. Key trends from this edition of the report include the following: -Evolution of state RPS programs: Significant RPS-related policy revisions since the start of 2016 include increased RPS targets in DC, MD, MI, NY, RI, and OR; requirements for new wind and solar projects and other major reforms to the RPS procurement process in IL; and a new offshore wind carve-out and solar procurement program in MA. -Historical impacts on renewables development: Roughly half of all growth in U.S. renewable electricity (RE) generation and capacity since 2000 is associated with state RPS requirements. Nationally, the role of RPS policies has diminished over time, representing 44% of all U.S. RE capacity additions in 2016. However, within particular regions, RPS policies continue to play a central role in supporting RE growth, constituting 70-90% of 2016 RE capacity additions in the West, Mid-Atlantic, and Northeast. -Future RPS demand and incremental needs: Meeting RPS demand growth will require roughly a 50% increase in U.S. RE generation by 2030, equating to 55 GW of new RE capacity. To meet future RPS demand, total U.S. RE generation will need to reach 13% of electricity sales by 2030 (compared to 10% today), though other drivers will also continue to influence RE growth. -RPS target achievement to-date: States have generally met their interim RPS targets in recent years, with only a few exceptions reflecting unique state-specific policy designs. -REC pricing trends: Prices for renewable energy

  14. Annual Status Report (FY2013 Composite Analysis of Low Level Waste Disposal in the Central Plateau at the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, W. E. [CH2M HILL Plateau Remediation Company, Richland, WA (United States)

    2014-03-25

    In accordance with U.S. Department of Energy (DOE) requirements in DOE O 435.1, 3 Chg. 11, and as implemented by DOE/RL-2000-29, Rev. 22, the DOE Richland Operations 4 Office (DOE-RL) has prepared this annual summary of the Hanford Site Composite Analysis 5 for fiscal year (FY) 2013.

  15. Uranium Mill Tailings Remedial Action Program. Annual status report

    International Nuclear Information System (INIS)

    1982-12-01

    Progress made during FY 1982, present status, and plans for FY 1983 are described for the following programs: radiological surveys and inclusion of vicinity properties; establishment of cooperative agreements; promulgation of standards for remedial action; acquisition of lands and materials; reprocessing of residual radioactive materials; National Environmental Policy Act (NEPA) documentation; program planning; technology development; remedial action; public participation; other federal agency activities; state and Indian tribe activities; and status of designated sites. Program funding is given

  16. 1980 Annual status report: operation of the high flux reactor

    International Nuclear Information System (INIS)

    1981-01-01

    HFR Petten has been operated in 1980 in fulfilment of the 1980/83 JRC Programme Decision. Both reactor operation and utilization data have been met within a few percent of the goals set out in the annual working schedule, in support of a large variety of research programmes. Major improvements to experimental facilities have been introduced during the year and future modernization has been prepared

  17. Groundwater Annual Status Report for Fiscal Year 1998

    International Nuclear Information System (INIS)

    A. K. Stoker; A. S. Johnson; B. D. Newman; B. M. Gallaher; C. L. Nylander; D. B. Rogers; D. E. Broxton; D. Katzman; E. H. Keating; G. L. Cole; K. A. Bitner; K. I. Mullen; P. Longmire; S. G. McLin; W. J. Stone

    1999-01-01

    Groundwater protection activities and hydrogeologic characterization studies are conducted at LANL annually. A summary of fiscal year 1998 results and findings shows increased understanding of the hydrogeologic environment beneath the Pajarito Plateau and significant refinement to elements of the LANL Hydrogeologic Conceptual Model pertaining to areas and sources of recharge to the regional aquifer. Modeling, drilling, monitoring, and data collection activities are proposed for fiscal year 1999

  18. Groundwater Annual Status Report for Fiscal Year 1999

    International Nuclear Information System (INIS)

    Nylander, C.L.; Bitner, K.A.; Henning, K.; Johnson, A.S.; Keating, E.H.; Longmire, P.; Newman, B.D.; Robinson, B.; Rogers, D.B.; Stone, W.J.; Vaniman, D.

    2000-01-01

    Groundwater protection activities and hydrogeologic characterization studies are conducted at Los Alamos National Laboratory annually. A summary of fiscal year 1999 results and findings shows increased understanding of the hydrogeologic environment beneath the Pajarito Plateau and significant refinement to elements of the LANL. Hydrogeologic Conceptual Model pertaining to areas and sources of recharge to the regional aquifer. Modeling, drilling, monitoring, and data collection activities are proposed for fiscal year 2000

  19. Administrative Circulars Rev.

    CERN Multimedia

    2003-01-01

    Administrative Circular N° 19 (Rev. 3) - April 2003 Subsistence indemnity - Other expenses necessarily incurred in the course of duty travelAdministrative Circular N° 25 (Rev. 2) - April 2003 Shift work - Special provisions for the Fire and Rescue Service - These circulars have been revised. Human Resources Division Tel. 74128Copies of these circulars are available in the Divisional Secretariats. In addition, administrative and operational circulars, as well as the lists of those in force, are available for consultation on the Web at: http://humanresources.web.cern.ch/humanresources/internal/admin_services/admincirc/listadmincirc.asp

  20. Status of safety at Areva group facilities. 2007 annual report

    International Nuclear Information System (INIS)

    2007-01-01

    This report describes the status of nuclear safety and radiation protection in the facilities of the AREVA group and gives information on radiation protection in the service operations, as observed through the inspection programs and analyses carried out by the General Inspectorate in 2007. Having been submitted to the group's Supervisory Board, this report is sent to the bodies representing the personnel. Content: 1 - A look back at 2007 by the AREVA General Inspector: Visible progress in 2007, Implementation of the Nuclear Safety Charter, Notable events; 2 - Status of nuclear safety and radiation protection in the nuclear facilities and service operations: Personnel radiation protection, Event tracking, Service operations, Criticality control, Radioactive waste and effluent management; 3 - Performance improvement actions; 4 - Description of the General Inspectorate; 5 - Glossary

  1. Status of national programmes on fast reactors 1998/99. 32nd annual meeting. Working material

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    Over the past 32 years, the IAEA has actively encouraged and advocated international cooperation in fast reactor technology. The present publication contains information on the status of fast reactor development and on worldwide activities in this advanced nuclear power technology during 1998/1999, as reported at the 32. annual meeting of the International Working Group on Fast Reactors. It is intended to provide information regarding the current status of LMFR development in IAEA Member States.

  2. Status of national programmes on fast reactors 1998/99. 32nd annual meeting. Working material

    International Nuclear Information System (INIS)

    1999-01-01

    Over the past 32 years, the IAEA has actively encouraged and advocated international cooperation in fast reactor technology. The present publication contains information on the status of fast reactor development and on worldwide activities in this advanced nuclear power technology during 1998/1999, as reported at the 32. annual meeting of the International Working Group on Fast Reactors. It is intended to provide information regarding the current status of LMFR development in IAEA Member States

  3. Status of safety at Areva group facilities. 2006 annual report

    International Nuclear Information System (INIS)

    2006-01-01

    This report presents a snapshot of nuclear safety and radiation protection conditions in the AREVA group's nuclear installations in France and abroad, as well as of radiation protection aspects in service activities, as identified over the course of the annual inspections and analyses program carried out by the General Inspectorate in 2006. This report is presented to the AREVA Supervisory Board, communicated to the labor representation bodies concerned, and made public. In light of the inspections, appraisals and coordination missions it has performed, the General Inspectorate considers that the nuclear safety level of the AREVA group's nuclear installations is satisfactory. It particularly noted positive changes on numerous sites and efforts in the field of continuous improvement that have helped to strengthen nuclear safety. This has been possible through the full involvement of management teams, an improvement effort initiated by upper management, actions to increase personnel awareness of nuclear safety culture, and supervisors' heightened presence around operators. However, the occurrence of certain events in facilities has led us to question the nuclear safety repercussions that the changes to activities or organization on some sites have had. In these times of change, drifts in nuclear safety culture have been identified. The General Inspectorate considers that a preliminary analysis of the human and organizational factors of these changes, sized to match the impact the change has on nuclear safety, should be made to ensure that a guaranteed level of nuclear safety is maintained (allowance for changes to references, availability of the necessary skills, resources of the operating and support structures, etc.). Preparations should also be made to monitor the changes and spot any telltale signs of drift in the application phase. Managers should be extra vigilant and the occurrence of any drift should be systematically dealt with ahead of implementing

  4. 2014 SRNL LDRD Annual Report, Rev. 0

    Energy Technology Data Exchange (ETDEWEB)

    Mcwhorter, S. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-03-15

    Laboratory Directed Research and Development is a congressionally authorized program that provides the ‘innovation inspiration’ from which many of the Laboratory’s multi-discipline advancements are made in both science and engineering technology. The program is the backbone for insuring that scientific, technical and engineering capabilities can meet current and future needs. It is an important tool in reducing the probability of technological surprise by allowing laboratory technical staff room to innovate and keep abreast of scientific breakthroughs. Drawing from the synergism among the EM and NNSA missions, and work from other federal agencies ensures that LDRD is the key element in maintaining the vitality of SRNL’s technical programs. The LDRD program aims to position the Laboratory for new business in clean energy, national security, nuclear materials management and environmental stewardship by leveraging the unique capabilities of the Laboratory to yield foundational scientific research in core business areas, while aligning with SRS strategic initiatives and maintaining a vision for ultimate DOE applications.

  5. Resident fish stock status above Chief Joseph and Grand Coulee dams : 2000 annual report; ANNUAL

    International Nuclear Information System (INIS)

    Lockwood, N.; McLellan, J.; Crossley, B.

    2001-01-01

    The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, commonly known as the Joint Stock Assessment Project (JSAP) is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (blocked area). The three-phase approach of this project will enhance the fisheries resources of the blocked area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information housed in a central location will allow managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP (NWPPC program measure 10.8B.26) is designed and guided jointly by fisheries managers in the blocked area and the Columbia Basin blocked area management plan (1998). The initial year of the project (1997) identified the need for a central data storage and analysis facility, coordination with the StreamNet project, compilation of blocked area fisheries information, and a report on the ecological condition of the Spokane River System. These needs were addressed in 1998 by acquiring a central location with a data storage and analysis system, coordinating a pilot project with StreamNet, compiling fisheries distribution data throughout the blocked area, identifying data gaps based on compiled information, and researching the ecological condition of the Spokane River. In order to ensure that any additional information collected throughout the life of this project will be easily stored and manipulated by the central storage facility, it was necessary to develop standardized methodologies between the JSAP fisheries managers. The use of common collection and analytical tools is essential to the process of streamlining joint management decisions. In 1999 and 2000 the project

  6. Annual status report on the Uranium Mill Tailings Remedial Action Program

    International Nuclear Information System (INIS)

    1992-12-01

    This fourteenth annual status report for the Uranium Mill Tailings Remedial Action (UMTRA) Project Office summarizes activities of the Uranium Mill Tailings Remedial Action Surface (UMTRA-Surface) and Uranium Mill Tailings Remedial Action Groundwater (UMTRA-Groundwater) Projects undertaken during fiscal year (FY) 1992 by the US Department of Energy (DOE) and other agencies. Project goals for FY 1993 are also presented. An annual report of this type was a statutory requirement through January 1, 1986, pursuant to the Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978, Public Law (PL) 95-604. The DOE will continue to submit annual reports to DOE-Headquarters, the states, tribes, and local representatives through Project completion in order to inform the public of the yearly Project status. The purpose of the remedial action is to stabilize and control the tailings and other residual radioactive material (RRM) located on the inactive uranium processing sites in a safe and environmentally sound manner, and to minimize or eliminate potential health hazards. Commercial and residential properties near designated processing sites that are contaminated with material from the sites, herein referred to as ''vicinity properties (VP),'' are also eligible for remedial action. Included in the UMTRA Project are 24 inactive uranium processing sites and associated VPs located in 10 states, and the VPs associated with the Edgemont, South Dakota, uranium mill currently owned by the Tennessee Valley Authority (TVA) (Figure A.1, Appendix A)

  7. Annual status report on the Uranium Mill Tailings Remedial Action Program

    Energy Technology Data Exchange (ETDEWEB)

    1989-12-01

    This eleventh annual status report summarizes activities of the Uranium Mill Tailings Remedial Action (UMTRA) Project undertaken during Fiscal Year (FY) 1989 by the US Department of Energy (DOE) and other agencies. Project goals for FY 1990 are also presented. An annual report of this type was a statutory requirement through January 1, 1986, pursuant to the Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978, Public Law (PL) 95--604. The DOE will continue to submit an annual report through project completion in order to inform the public of yearly project status. Title I of the UMTRCA authorizes the DOE, in cooperation with affected states and Indian tribes within whose boundaries designated uranium processing sites are located, to provide a program of assessment and remedial action at such sites. The purpose of the remedial action is to stabilize and control the tailings and other residual radioactive materials located on the inactive uranium processing sites in a safe and environmentally sound manner and to minimize or eliminate potential radiation health hazards. Commercial and residential properties in the vicinity of designated processing sites that are contaminated with material from the sites, herein referred to as vicinity properties,'' are also eligible for remedial action. Included in the UMTRA Project are 24 inactive uranium processing sites and associated vicinity properties located in 10 states, and the vicinity properties associated with Edgemont, South Dakota, an inactive uranium mill currently owned by the Tennessee Valley Authority (TVA).

  8. Annual status report on the Uranium Mill Tailings Remedial Action Program

    International Nuclear Information System (INIS)

    1989-12-01

    This eleventh annual status report summarizes activities of the Uranium Mill Tailings Remedial Action (UMTRA) Project undertaken during Fiscal Year (FY) 1989 by the US Department of Energy (DOE) and other agencies. Project goals for FY 1990 are also presented. An annual report of this type was a statutory requirement through January 1, 1986, pursuant to the Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978, Public Law (PL) 95--604. The DOE will continue to submit an annual report through project completion in order to inform the public of yearly project status. Title I of the UMTRCA authorizes the DOE, in cooperation with affected states and Indian tribes within whose boundaries designated uranium processing sites are located, to provide a program of assessment and remedial action at such sites. The purpose of the remedial action is to stabilize and control the tailings and other residual radioactive materials located on the inactive uranium processing sites in a safe and environmentally sound manner and to minimize or eliminate potential radiation health hazards. Commercial and residential properties in the vicinity of designated processing sites that are contaminated with material from the sites, herein referred to as ''vicinity properties,'' are also eligible for remedial action. Included in the UMTRA Project are 24 inactive uranium processing sites and associated vicinity properties located in 10 states, and the vicinity properties associated with Edgemont, South Dakota, an inactive uranium mill currently owned by the Tennessee Valley Authority (TVA)

  9. Annual Report of the Integrated Status and Effectiveness Monitoring Program: Fiscal Year 2008

    Energy Technology Data Exchange (ETDEWEB)

    Terraqua, Inc. (Wauconda, WA)

    2009-07-20

    This document was created as an annual report detailing the accomplishments of the Integrated Status and Effectiveness Monitoring Program (ISEMP) in the Upper Columbia Basin in fiscal year 2008. The report consists of sub-chapters that reflect the various components of the program. Chapter 1 presents a report on programmatic coordination and accomplishments, and Chapters 2 through 4 provide a review of how ISEMP has progressed during the 2008 fiscal year in each of the pilot project subbasins: the John Day (Chapter 2), Wenatchee/Entiat (Chapter 3) and Salmon River (Chapter 4). Chapter 5 presents a report on the data management accomplishments in 2008.

  10. Subseabed disposal program annual report, January-December 1979. Volume I. Summary and status

    International Nuclear Information System (INIS)

    Talbert, D.M.

    1981-08-01

    This is the sixth annual report describing the progress and evaluating the status of the Subseabed Disposal Program, which was begun in June 1973. The program was initiated by Sandia National Laboratories to explore the utility of stable, uniform, and relatively unproductive areas of the world's oceans as possible repositories for high-level nuclear wastes. The program, now international in scope, is currently focused on the stable submarine geologic formations under the deep oceans. Summaries are presented in the following areas: systems analysis; barrier system characterization and assessment; environmental studies; emplacement; sampling and instrumentation development; and transportation studies

  11. Status of national programmes on fast breeder reactors. Eighteenth annual meeting, Vienna, Austria, 16-19 April 1985

    International Nuclear Information System (INIS)

    1986-02-01

    The Eighteenth Annual Meeting on the Status of National Programmes in Member States of the IAEA on Fast Breeder Reactors had been held in April 1985. The representatives of the Member States and international organizations reported status and activities in the field of fast breeder reactors development and operation. A separate abstract was prepared for each of the 12 presentations of the meeting

  12. Soil water status under perennial and annual pastures on an acid duplex soil

    International Nuclear Information System (INIS)

    Heng, L.K.; White, R.E.; Chen, D.

    2000-01-01

    A comprehensive field study of soil water balance, nitrogen (N) cycling, pasture management and animal production was carried out on an acid duplex soil at Book Book near Wagga Wagga in southern New South Wales. The experiment, carried out over a 3-year period, tested the hypothesis that sown perennial grass pastures improve the sustainability of a grazing system through better use of water and N. The treatments were: annual pastures without lime (AP-), annual pastures with lime (AP+), perennial pastures without lime (PP-) and perennial pastures with lime (PP+). Soil water measurement was made using a neutron probe on one set of the treatments comprising four adjacent paddocks. Over three winter and spring periods, the results showed that perennial grass pastures, especially PP+, consistently extracted about 40 mm more soil water each year than did the annual grass pastures. As a result, surface runoff, sub-surface flow and deep drainage (percolation below 180 cm depth) were about 40 mm less from the perennial pastures. The soil water status of the four pasture treatments was simulated reasonably well using a simple soil water model. Together with the long-term simulation of deep drainage, using past meteorological records, it is shown that proper management of perennial pastures can reduce recharge to groundwater and make pastoral systems more sustainable in the high rainfall zone. However, to completely reduce recharge, more-deeply rooted plants or trees are needed. (author)

  13. Radiotherapy. 2. rev. ed.

    International Nuclear Information System (INIS)

    Wannenmacher, Michael; Debus, Juergen; Wenz, Frederik

    2013-01-01

    The purpose of this medical specialty book, besides presenting the state of the art in clinical radiotherapy and radiooncology, is to explain the basic principles of medical physics and radiobiology. Following a number of chapters on general topics and theory it provides detailed coverage of the individual organ systems, briefly addressing future aspects in the process. The authors relate their view that radiooncology as a medical specialty will continue to be under pressure to change and that it will take continuous innovation to secure its status within the interdisciplinary context around the treatment of cancer patients. The authors of this, the textbook's second edition, have dedicated much space to modern methods and techniques in order to do justice to these developments.

  14. Administrative Circular No. 26 (Rev. 9) – Recognition of Merit

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 26 (Rev. 9) entitled "Recognition of Merit”, approved by the Director-General following discussion in the Standing Concertation Committee meeting on 27 September 2011 is available on the intranet site of the Human Resources Department: https://cern.ch/hr-docs/admincirc/admincirc.asp The circular was above all revised in order to integrate the new CERN Competency Model into the annual procedure of performance appraisal. It cancels and replaces Administrative Circular No. 26 (Rev. 8) entitled "Recognition of merit” of September 2008. Department Head Office HR Department

  15. AREVA General Inspectorate Annual Report 2013 - Status of safety in nuclear facilities

    International Nuclear Information System (INIS)

    Oursel, Luc; Riou, Jean

    2014-06-01

    This annual report by AREVA's General Inspectorate deals with the status of nuclear safety and radiation protection in the group's facilities and operations over the course of 2013. Based on the findings made during implementation of the annual inspection program, this annual report also includes the results of the analysis of significant events and the observations and assessments of specialists in the Safety Health Security Sustainable Development Department (SHSSDD), supplemented by regular interaction with the safety regulators, different government agencies, stakeholders and other nuclear operators. Additionally, this report presents the action plans put into motion and the directions taken for continuous improvement in risk prevention for operations conducted in France and internationally. In 2013, the level of safety in the group's nuclear facilities and operations remained satisfactory, although improvements are necessary in some domains. This report is based on established indicators, analyses of reported events, responses to commitments made to the regulators, and the results of different improvement actions reported on in the inspected and supported entities. In 2013, no level 2 event on the International Nuclear and Radiological Event Scale (INES) was reported, the bottom-up reporting of weak signals was confirmed, dose levels were low and there were no radiological impacts on the environment. The General Inspectorate conducted 45 inspections in 30 of the group's entities in 2013. Of these, 10 concerned sites outside France and 7 were conducted following events or particular situations. These inspections gave rise to 176 recommendations, which the inspected entities have translated into action plans. Verification of these different action plans according to planned procedures and announced schedules gave rise to 16 follow-up inspections. The major lessons learned from these inspections relate to project management, facility compliance and operational

  16. Kootenai River Fisheries Investigation : Stock Status of Burbot : Project Progress Report 2008 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Paragamian, Valughn L.; Laude Dorothy C.

    2008-12-26

    Objectives of this investigation were to (1) monitor the population status and recruitment of burbot Lota lota in the Kootenai River, Idaho and British Columbia, Canada during the winter of 2006-2007; (2) evaluate the selective withdrawal system in place at Libby Dam to maintain the river temperature near Bonners Ferry between 1-4 C (November-December) to improve burbot migration and spawning activity; and (3) determine if a hatching success of 10% of eyed burbot embryos could be achieved through extensive rearing and produce fingerlings averaging 9.8 cm in six months. Water temperature did not fall below the upper limit (4 C) until mid-January but was usually maintained between 1-4 C January through February and was acceptable. Snowpack was characterized by a 101% of normal January runoff forecast. Adult burbot were sampled with hoop nets and slat traps. Only three burbot were captured in hoop nets, all at Ambush Rock (rkm 244.5). No burbot were caught in either slat traps or juvenile sampling gear, indicating the population is nearly extirpated. Burbot catch per unit effort in hoop nets was 0.003 fish/net d. Extensive rearing was moved to a smaller private pond and will be reported in the 2008-2009 annual report.

  17. MHD Technology Transfer, Integration and Review Committee. Seventh semi-annual status report, April 1991--September 1991

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    This seventh semi-annual status report of the MHD Technology Transfer, Integration and Review Committee (TTIRC) summarizes activities of the TTIRC during the period April 1991 through September 1991. It includes a summary and minutes of the General Committee meeting, progress summaries of ongoing POC contracts, discussions pertaining to technical integration issues in the POC program, and planned activities for the next six months. The meeting included test plan with Western coal, seed regeneration economics, power management for the integrated topping cycle and status of the Clean Coal Technology Proposal activities. Appendices cover CDIF operations HRSR development, CFFF operations etc.

  18. Annual Status Report (Fiscal Year 2012) Composite Analysis of Low-Level Waste Disposal in the Central Plateau at the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, W. E. [CH2M HILL Plateau Remediation Company, Richland, WA (United States)

    2012-12-27

    In accordance with U.S. Department of Energy (DOE) requirements in DOE O 435.1, Chg. 1,1 and as implemented by DOE/RL-2000-29, Rev. 2,2 the DOE Richland Operations Office (DOE-RL) has prepared this annual summary of the Hanford Site Composite Analysis for fiscal year (FY) 2012, as originally reported in PNNL-118003 and PNNL-11800, Addendum 14 (hereafter these reports are referred to collectively as the Composite Analysis), and to address secondary issues identified during the review of the Composite Analysis.

  19. Semi-annual status report of the Canadian Nuclear Fuel Waste Management Program, April 1--September 30, 1991

    Energy Technology Data Exchange (ETDEWEB)

    Wright, E. D. [comp.

    1992-02-01

    This report is the eleventh in a series of semi-annual status reports on the research and development program for the safe management and disposal of Canada's nuclear fuel waste. it describes progress achieved in the three major subprograms, engineered systems, natural systems and performance assessment, from 1991 April 1 to September 30. It also gives a brief description of the activities being carried out in preparation for the public and governmental review of the disposal concept. Since 1987, this program has been jointly funded by AECL and Ontario Hydro under the auspices of the CANDU Owners Group (COG).

  20. Annual Status Report (FY2014) 200 West and 200 East Performance Assessments

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, W. E. [CH2M Hill Plateau Remediation Company, Richland, WA (United States); Khaleel, R. [INTERA, Inc., Austin, TX (United States); Mehta, S. [CH2M Hill Plateau Remediation Company, Richland, WA (United States)

    2015-03-24

    This annual review provides the projected dose estimates of radionuclide inventories disposed in the active Low-Level Waste Burial Grounds (LLBGs) since September 26, 1988. These estimates are calculated using the original does methodology developed in the performance assessment analyses.

  1. Optimized Chemical Probes for REV-ERBα

    OpenAIRE

    Trump, Ryan P.; Bresciani, Stefano; Cooper, Anthony W. J.; Tellam, James P.; Wojno, Justyna; Blaikley, John; Orband-Miller, Lisa A.; Kashatus, Jennifer A.; Dawson, Helen C.; Loudon, Andrew; Ray, David; Grant, Daniel; Farrow, Stuart N.; Willson, Timothy M.; Tomkinson, Nicholas C. O.

    2013-01-01

    REV-ERBα has emerged as an important target for regulation of circadian rhythm and its associated physiology. Herein, we report on the optimization of a series of REV-ERBα agonists based on GSK4112 (1) for potency, selectivity, and bioavailability. Potent REV-ERBα agonists 4, 10, 16, and 23 are detailed for their ability to suppress BMAL and IL-6 expression from human cells while also demonstrating excellent selectivity over LXRα. Amine 4 demonstrated in vivo bioavailability after either IV o...

  2. Power Generation and Transportation Systems Research Department: 1992 annual status report (Gas Research Institute)

    International Nuclear Information System (INIS)

    Benedict, A.

    1992-09-01

    Activities of Gas Research Institute's Power Generation and Transportation Systems subprogram for the period between October 1, 1991 and September 30, 1992 are summarized. The particular project areas covered in the report are Cogeneration and Power Systems, Engine Technology and Component Development, Natural Gas Vehicles Research, and Electric Power Generation. For each project area a separate chapter is provided. Each chapter includes a rationale for funding the research effort, the goals and objectives to be achieved, a general statement on research accomplishments, and the strategy employed in the project area. Each chapter also contains a series of summary reports on the status of each contract

  3. Anthropogenic SO2/NOx committee summary of current status--annual inventory

    International Nuclear Information System (INIS)

    Benkovitz, C.M.

    1992-06-01

    At the First GEIA Workshop on Global Emissions Inventories, held in Baltimore, MD on December 1--2, 1991, data on anthropogenic emissions of sulfur and nitrogen developed by Dignon (1992) were selected to form the basis for the GEIA SO 2 and NO x annual inventories. The Dignon data include emissions from fuel combustion only and currently extend to 1980. The methodology used was detailed in Dignon and Hameed (1985) and consists of statistical regression models based on available emissions data from the U.S and some other member countries of the Organization of Economic Cooperation and Development (OECD), which includes Australia, Canada, Japan and western European countries. Control regulations are incorporated via the use of different statistical parameter The grid definition from these inventories was also adopted for the GEIA grid: origin at 180 degree W, 90 degree S, 1 degree x 1 degree resolution (i.e., 360 cells in the longitude direction, 180 cells in the latitude direction). To upgrade the basic GEIA inventories, data for the different geographic regions being solicited from researchers located within these areas. This paper contains the upgrades which have been accomplished to date

  4. Status of safety in nuclear facilities - 2012. AREVA General Inspectorate Annual report

    International Nuclear Information System (INIS)

    2013-05-01

    After a message from the Areva's Chief Executive Officer and a message from the senior Vice President of safety, health, security, sustainable development, a text by the inspector general comments the key safety results (events, dose levels, radiological impacts), the inspection findings, the areas of vigilance (relationship with the ASN, the management of the criticality risk, and facility compliance), some significant topics after the Fukushima accident. Then this report addresses the status of nuclear safety and radiation protection in the group's facilities and operations. It more specifically addresses the context and findings (lessons learned from the inspections, operating experience from event, employee radiation monitoring, environmental monitoring), crosscutting processes (safety management, controlling facility compliance, subcontractor guidance and management, crisis management), specific risks (criticality risk, fire hazards, transportation safety, radioactive waste management, pollution prevention, liability mitigation and dismantling), and areas for improvement and outlook

  5. Potentiometric-level monitoring program, Mississippi and Louisiana: Annual status report for fiscal year 1985

    International Nuclear Information System (INIS)

    1986-10-01

    Potentiometric-level data presented in this report were collected at 82 wells in Mississippi and Louisiana from October 1984 through September 1985. These wells are located near Richton and Cypress Creek Domes in Mississippi and Vacherie dome in Louisiana. Three wells were reinstated to the program during this period. Two previously destroyed wells were deleted from the program. Protective barriers were installed around 26 shallow borings in Mississippi. Cursory analysis of the data in Mississippi indicated minimal, if any, change in potentiometric level during the past year in the Citronelle, Hattiesburg, Cockfield, Sparta, and Wilcox Formations. A slight decline, on the order of 0.3 meter (1 foot), occurred during the past year in well MCCG-1, which is screened in the caprock of Cypress Creek Dome. The potentiometric level in well MRIG-9, in the caprock of Richton Dome, stabilized during fiscal year 1985 following 5 years of increase. The Catahoula Formation experienced a continuing decline of about 0.3 meter/year (1 foot/year). Well MH-5C, screened in the Cook Mountain Formation, showed a continuing, long-term, upward trend on the order of 1.5 meters (4.9 feet) during the past year. The potentiometric level of well MH-8C, screened in the Cook Mountain Formation, stabilized during fiscal year 1985, following 5 years of large annual increases. Wells screened in the Austin Formation in Louisiana showed a downward trend of 0.3 to 1 meter (1 to 3.3 feet) during fiscal year 1985. Other formations in Louisiana generally showed no change in potentiometric level

  6. Evaluate Status of Pacific Lamprey in the Clearwater River Drainage, Idaho, Annual Report 2002.

    Energy Technology Data Exchange (ETDEWEB)

    Cochnauer, Tim; Claire, Christopher

    2003-10-01

    In 2002 Idaho Department of Fish and Game continued investigation into the status of Pacific lamprey populations in Idaho's Clearwater River drainage. Trapping, electrofishing, and spawning ground redd surveys were used to determine Pacific lamprey distribution, life history strategies, and habitat requirements in the South Fork Clearwater River, Lochsa River, Selway River, and Middle Fork Clearwater River subbasins. Five-hundred forty-one ammocoetes were captured electroshocking 70 sites in the South Fork Clearwater River, Lochsa River, Selway River, Middle Fork Clearwater River, Clearwater River, and their tributaries in 2002. Habitat utilization surveys in Red River support previous work indicating Pacific lamprey ammocoete densities are greater in lateral scour pool habitats compared to riffles and rapids. Presence-absence survey findings in 2002 augmented 2000 and 2001 indicating Pacific lamprey macrothalmia and ammocoetes are not numerous or widely distributed. Pacific lamprey distribution was confined to the lower reaches of Red River below rkm 8.0, the South Fork Clearwater River, Lochsa River (Ginger Creek to mouth), Selway River (Race Creek to mouth), Middle Fork Clearwater River, and the Clearwater River (downstream to Potlatch River).

  7. Discovery of endangered annual killifish Austrolebias cheradophilus (Aplocheiloidei: Rivulidae in Brazil, with comments on habitat, population structure and conservation status

    Directory of Open Access Journals (Sweden)

    Luis Esteban Krause Lanés

    Full Text Available Austrolebias genus comprises about 40 small annual killifishes endemic to South America and their highest diversity occurs in southern Brazil and Uruguay, especially in drainages of Patos-Mirim system. Austrolebiasspecies are severely threatened with extinction because their life cycle and restricted ranges. Low dispersal ability and the extensive loss and fragmentation of freshwater wetlands contribute to this threat. Accurate information on the geographic distribution and ecology of the species, vital to plan conservation and management strategies, are scarce. In order to provide basic knowledge for annual fish conservation this paper reports the presence of Austrolebias cheradophilus and present data about its population structure (CPUA, size, sex ratio, length-weight relationships and condition factor and conservation status in southern Brazil. The estimated CPUA of populations was 0.86 fish/m2. Standard length (SL of males ranged between 32.14 and 49.17 mm and for females between 25.11 and 41.6 mm. There were no differences in SL between the sexes (t-test = - 1.678; P = 0.105, and Chi-squared test demonstrated marginal differences in proportions of sexes (2.25:1; χ2 = 3.846; P= 0.07. Allometric coefficient of the LWR was slightly hyperallometric (b = 3.08 and K of the specimens ranged from 1.84 to 2.42 (mean ± S.E. = 2.12 ± 0.04. Populations have low density and their biotopes are under critical threat, mainly due to suppression by agriculture, pastures for livestock and increase housing. The species is considered "Critically Endangered" in Brazil, furthermore is strongly recommended its inclusion on lists of endangered fauna and ensures the protection of their remaining habitats.

  8. Evaluate Status of Pacific Lamprey in the Clearwater River Drainage, Idaho: Annual Report 2001.

    Energy Technology Data Exchange (ETDEWEB)

    Cochnauer, Tim; Claire, Christopher

    2002-12-01

    Recent decline of Pacific lamprey Lampetra tridentata adult migrants to the Snake River drainage has focused attention on the species. Adult Pacific lamprey counted passing Ice Harbor Dam fishway averaged 18,158 during 1962-69 and 361 during 1993-2000. Human resource manipulations in the Snake River and Clearwater River drainages have altered ecosystem habitat in the last 120 years, likely impacting the productive potential of Pacific lamprey habitat. Timber harvest, stream impoundment, road construction, grazing, mining, and community development have dominated habitat alteration in the Clearwater River system and Snake River corridor. Hydroelectric projects in the Snake River corridor impact juvenile/larval Pacific lamprey outmigrants and returning adults. Juvenile and larval lamprey outmigrants potentially pass through turbines, turbine bypass/collection systems, and over spillway structures at the four lower Snake River hydroelectric dams. Clearwater River drainage hydroelectric facilities have impacted Pacific lamprey populations to an unknown degree. The Pacific Power and Light Dam on the Clearwater River in Lewiston, Idaho, restricted chinook salmon Oncorhynchus tshawytscha passage in the 1927-1940 period, altering the migration route of outmigrating Pacific lamprey juveniles/larvae and upstream adult migrants (1927-1972). Dworshak Dam, completed in 1972, eliminated Pacific lamprey spawning and rearing in the North Fork Clearwater River drainage. Construction of the Harpster hydroelectric dam on the South Fork of the Clearwater River resulted in obstructed fish passage 1949-1963. Through Bonneville Power Administration support, the Idaho Department of Fish and Game continued investigation into the status of Pacific lamprey populations in Idaho's Clearwater River drainage in 2001. Trapping, electrofishing, and spawning ground redd surveys were used to determine Pacific lamprey distribution, life history strategies, and habitat requirements in the South

  9. Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams; 2000 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Lockwood, Jr., Neil [Kalispel Tribe of Indians, Usk, WA (United States); McLellan, Jason G [Washington Department of Fish and Wildlife, Spokane, WA (United States); Crossley, Brian [Spokane Tribe of Indians, Department of Natural Resources, Wellpinit, WA (United States); O' Connor, Dick

    2001-01-01

    The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, commonly known as the Joint Stock Assessment Project (JSAP) is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (blocked area). The three-phase approach of this project will enhance the fisheries resources of the blocked area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information housed in a central location will allow managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP (NWPPC program measure 10.8B.26) is designed and guided jointly by fisheries managers in the blocked area and the Columbia Basin blocked area management plan (1998). The initial year of the project (1997) identified the need for a central data storage and analysis facility, coordination with the StreamNet project, compilation of blocked area fisheries information, and a report on the ecological condition of the Spokane River System. These needs were addressed in 1998 by acquiring a central location with a data storage and analysis system, coordinating a pilot project with StreamNet, compiling fisheries distribution data throughout the blocked area, identifying data gaps based on compiled information, and researching the ecological condition of the Spokane River. In order to ensure that any additional information collected throughout the life of this project will be easily stored and manipulated by the central storage facility, it was necessary to develop standardized methodologies between the JSAP fisheries managers. The use of common collection and analytical tools is essential to the process of streamlining joint management decisions. In 1999 and 2000 the project

  10. Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams; 2001 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Connor, Jason M. (Kalispell Department of Natural Resources, Usk, WA); McLellan, Jason G. (Washington Department of Fish and Wildlife, Spokane, WA); O' Connor, Dick (Washington Department of Fish and Wildlife, Olympia, WA)

    2003-01-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power Planning Council (NPPC). The NPPC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPPC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area and the Columbia Basin Blocked Area Management Plan

  11. Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams; 2002-2003 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Connor, Jason M. (Kalispel Tribe of Indians, Usk, WA); McLellan, Jason G. (Washington Department of Fish and Wildlife); Butler, Chris (Spokane Tribe of Indians, Wellpinit, WA)

    2006-02-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power and Conservation Council (NPCC), formerly the Northwest Power Planning Council. The NPCC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPCC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial and native fish assemblages in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area. The

  12. Quicklook overview of model changes in Melcor 2.2: Rev 6342 to Rev 9496

    Energy Technology Data Exchange (ETDEWEB)

    Humphries, Larry L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-05-01

    MELCOR 2.2 is a significant official release of the MELCOR code with many new models and model improvements. This report provides the code user with a quick review and characterization of new models added, changes to existing models, the effect of code changes during this code development cycle (rev 6342 to rev 9496), a preview of validation results with this code version. More detailed information is found in the code Subversion logs as well as the User Guide and Reference Manuals.

  13. Administrative Circular No. 11 (Rev. 4) - Categories of members of the personnel

    CERN Multimedia

    HR Department

    2016-01-01

    Administrative Circular No. 11 (Rev. 4) entitled "Categories of members of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 29 April 2016, will be available on 1 August 2016 via this following link.    This revised circular cancels and replaces the Administrative Circular No. 11 (Rev. 3) also entitled "Categories of members of the personnel" of September 2014. The main changes concern the status of apprentices and their transfer from the category of employed members of personnel to associated members of personnel. This circular will enter into force on 1 August 2016. Department Head Office

  14. Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function

    DEFF Research Database (Denmark)

    Bugge, Anne Skovsø; Feng, Dan; Everett, Logan J

    2012-01-01

    of binding sites across the genome, enriched near metabolic genes. Depletion of both Rev-erbs in liver synergistically derepresses several metabolic genes as well as genes that control the positive limb of the molecular clock. Moreover, deficiency of both Rev-erbs causes marked hepatic steatosis, in contrast......-autonomous clock as well as hepatic lipid metabolism. Mouse embryonic fibroblasts were rendered arrhythmic by depletion of both Rev-erbs. In mouse livers, Rev-erbβ mRNA and protein levels oscillate with a diurnal pattern similar to that of Rev-erbα, and both Rev-erbs are recruited to a remarkably similar set...

  15. Revised Safety Instruction 41 (IS41 REV.)

    CERN Multimedia

    SC Secretariat

    2005-01-01

    Please note that the Revised Safety Instruction No. 41 (IS41 REV.), entitled 'The use of plastic and other non-metallic materials at CERN with respect to fire safety and radiation resistance' is available on the web at the following url: https://edms.cern.ch/document/335806/LAST_RELEASED Paper copies can also be obtained from the SC Unit Secretariat, e-mail: sc.secretariat@cern.ch SC Secretariat

  16. Introducing RevPASH: The Free Webtool Application

    Directory of Open Access Journals (Sweden)

    Peter Szende

    2014-10-01

    Full Text Available RevPASH (Revenue Per Available Seat Hour is an important measure that helps restaurant operators understand how efficiently each seat in a restaurant generates revenue. The RevPASH app is an easy-to-use web-tool that provides an operator with a quick way to input a few relevant numbers and calculate RevPASH.The application has the ability to compare RevPASH over different times, days, weeks, and months.

  17. Rev 12 as a theology of history

    OpenAIRE

    Joanna Nowińska

    2009-01-01

    The Biblical writers notice history as the space of God’s rule. He is the director, who comes into contact with human being through signs – events and words, and also He is the history’s perpetuum mobile. Rev 12 specifically reflect nowadays and the previous in the context of the whole world’s vision and mix the reference to facts (lack of the temple, ark, faithful people, horrible experiences, the death danger), places (the temple, a desert), persons (the Child-Ruler, Michael) with the Old T...

  18. Rev 12 as a theology of history

    Directory of Open Access Journals (Sweden)

    Joanna Nowińska

    2009-12-01

    Full Text Available The Biblical writers notice history as the space of God’s rule. He is the director, who comes into contact with human being through signs – events and words, and also He is the history’s perpetuum mobile. Rev 12 specifically reflect nowadays and the previous in the context of the whole world’s vision and mix the reference to facts (lack of the temple, ark, faithful people, horrible experiences, the death danger, places (the temple, a desert, persons (the Child-Ruler, Michael with the Old Testament figurative exposing, a typical one for such a book (the Woman with Child, the heaven, the dragon, enriched with a lot of symbols (a crown, a horn, the moon under feet. God’s interference into World history is presented through lightning, voices, thunder, an earthquake and great hail, that stress His power and supremacy. The biblical writer refers to events, which make place whole the time in the natural- and supernatural space, like: the war between God and evil, persecutions, hiding, God’s care of men.  The specific literary structure of Rev 12, contrary to the other parts of that book, seem to help to put an accent for the fundamental truths for transcendental theology of history of which the most important is the eternal rule of God and only accidental, finished in the time perspective of Satan’s position.

  19. Suppression of atherosclerosis by synthetic REV-ERB agonist

    Energy Technology Data Exchange (ETDEWEB)

    Sitaula, Sadichha [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Billon, Cyrielle [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States); Kamenecka, Theodore M.; Solt, Laura A. [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Burris, Thomas P., E-mail: burristp@slu.edu [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States)

    2015-05-08

    The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agonists that we have developed might have the ability to suppress atherosclerosis in this model. A previously characterized synthetic REV-ERB agonist, SR9009, was used to determine if activation of REV-ERB activity would affect atherosclerosis in LDL receptor deficient mice. Atherosclerotic plaque size was significantly reduced (p < 0.05) in mice administered SR9009 (100 mg/kg) for seven weeks compared to control mice (n = 10 per group). SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to proinflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages. Our results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for treatment of atherosclerosis. - Highlights: • Synthetic REV-ERB agonist treatment reduced atherosclerosis in a mouse model. • Pharmacological activation of REV-ERB decreased M1 macrophage polarization. • Pharmacological activation of REV-ERB increased M2 macrophage polarization.

  20. Annual Status Report (FY2009) Composite Analysis of Low-Level Waste Disposal in the Central Plateau at the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, W. E. [CH2M HILL Plateau Remediation Company, Richland, WA (United States)

    2010-02-10

    In accordance with the U.S. Department of Energy (DOE) requirements in DOE O 435.1, Radioactive Waste Management, and implemented by DOE/RL-2000-29, Maintenance Plan for the Composite Analysis of the Hanford Site, Southeast Washington, the DOE Richland Operations Office has prepared this annual status report for fiscal year (FY) 2009 of PNNL-11800, Composite Analysis for the Low-Level Waste Disposal in the 200-Area Plateau of the Hanford Site, hereafter referred to as the Composite Analysis.

  1. Annual Status Report (FY2010) Composite Analysis of Low-Level Waste Disposal in the Central Plateau at the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, W. E. [CH2M HILL Plateau Remediation Company, Richland, WA (United States)

    2011-01-11

    In accordance with the U.S. Department of Energy (DOE) requirements in DOE O 435.1 Chg 1, Radioactive Waste Management, and implemented by DOE/RL-2000-29, Maintenance Plan for the Composite Analysis of the Hanford Site, Southeast Washington, the DOE Richland Operations Office (DOE-RL), also known as RL, has prepared this annual status report for fiscal year (FY) 2010 of PNNL-11800, Composite Analysis for Low-Level Waste Disposal in the 200 Area Plateau of the Hanford Site, hereafter referred to as the Composite Analysis.

  2. Annual Status Report (FY 2017): Composite Analysis for Low Level Waste Disposal in the Central Plateau of the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Weber, M. C.; Nichols, W. E.; Lehman, L. L.

    2018-04-05

    In accordance with U.S. Department of Energy (DOE) requirements in DOE M 435.1 Chg. 1, and as implemented by DOE/RL-2009-29, the DOE Richland Operations Office has prepared this annual summary of the Hanford Site Composite Analysis for fiscal year 2017.

  3. Annual Status Report (FY2015) Composite Analysis for Low Level Waste Disposal in the Central Plateau of the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, W. E. [CH2M Hill Plateau Remediation Company, Richland, WA (United States)

    2016-03-24

    In accordance with U.S. Department of Energy (DOE) requirements in DOE O 435.1, and as implemented by DOE/RL-2000-29, the DOE Richland Operations Office has prepared this annual summary of the Hanford Site Composite Analysis for fiscal year 2015.

  4. Status of annual plant species in the Baneberry fallout pattern first and sixth years after initial irradiation

    International Nuclear Information System (INIS)

    Rhoads, W.A.

    1977-01-01

    At Project Baneberry on December 18, 1970, there was an accidental venting of radioactive debris into the environment which resulted in the irradiation of vegetation about 1.5 km to the north with doses estimated to reach a maximum of 6.2 K rads, beta plus gamma. At the highest doses, 35 percent of the dominant shrub in the area, Coleogyne (black brush), were killed and 65% severely damaged; and at lesser doses there was correspondingly less damage. Other species of shrubs were also affected. Grayia spinosa showed a low frequency of stem fasciation at the higher doses as well as other manifestations of radiation damage. In June 1971, the annual plant species which were probably small seedlings at fallout time were more frequently absent from the higher radiation areas than in the lower. At the same time, there was a greater frequency of higher dry weights produced by annuals at the higher radiation exposures. The frequency of occurrence of annuals varied from means of 8.5/m 2 at the higher doses to 24.3/m 2 at the lower doses. In June 1976, five years after irradiation, there were 300 to 400 plants/m 2 . By extrapolating the plants/m 2 against dose back to zero plants/m 2 , some indication of radiation doses which might destroy all annuals was derived

  5. Annual Status Report (FY2016) Composite Analysis for Low Level Waste Disposal in the Central Plateau of the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Weber, M. C. [INTERA, Inc., Austin, TX (United States); Nichols, W. E. [CH2M Hill Plateau Remediation Company, Richland, WA (United States)

    2017-03-14

    In accordance with U.S. Department of Energy (DOE) requirements in DOE O 435.1 and as implemented by DOE/RL-2009-29, the DOE Richland Operations Office has prepared this annual summary of the Hanford Site Composite Analysis for fiscal year 2016.

  6. Status and habitat requirements of white sturgeon populations in the Columbia River downstream from McNary Dam, annual progress report, July 1986 - March 1987.; ANNUAL

    International Nuclear Information System (INIS)

    Oregon Department of Fish and Wildlife; Washington Department of Fisheries

    1987-01-01

    Measure 804(e)(8) of the Northwest Power Planning Council (NPPC) Fish and Wildlife Program states that Bonneville Power Administration (BPA) ''shall fund research to determine the impacts of development and operation of the hydroelectric power system on sturgeon in the Columbia River Basin...'' In June 1985, BPA sponsored a workshop to define and list in priority order research needs in the basin (Fickeisen 1985a). In December 1985, BPA submitted a research program implementation plan (Fickeisen 1985b) to the NPPC. The purpose of the plan is to provide guidance for conducting research necessary to address four objectives identified by regional fishery interests for protecting, mitigating and enhancing white sturgeon populations in the Columbia River basin. The plan's objectives are: (1) Assess the current status of Columbia River basin white sturgeon stocks. (2) Provide the basis to evaluate the need for protection, mitigation and enhancement of white sturgeon in the Columbia River system. (3) Provide information that can be used to evaluate potential methods of protection, mitigation and enhancement of existing stocks. (4) Provide tools to assess the effectiveness of protection, mitigation and enhancement efforts

  7. Administrative Circular No. 14 (Rev. 2)

    CERN Document Server

    HR Department

    2007-01-01

    The HR Department wishes to draw the attention of members of the personnel to a number of amendments to Administrative Circular No. 14 (Rev. 2) entitled "Protection of members of the personnel against the financial consequences of illness, accident and disability" which came into force on 1st July 2006 (cf. Weekly Bulletin of 14 and 21 August 2006). Occupational Accident Declaration Form (HS50) https://cern.ch/service-procedures/AdminMan/Forms/HS50E.doc •\tIt must be completed within 10 working days of the date on which the accident occurred (§ 29.2.1), unless the person concerned is materially unable to meet this deadline. • The completed formula must be accompanied by a medical certificate giving details of any bodily injuries resulting from the accident (Annex 1, § 5). The medical certificate must be obtained from the doctor who has been consulted for that purpose. Benefits resulting from illnesses and accidents Medical treatment will cease to be reimbursed under ...

  8. Status of safety at Areva group facilities. 2007 annual report; Areva, etat de surete des installations nucleaires. Rapport annuel 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report describes the status of nuclear safety and radiation protection in the facilities of the AREVA group and gives information on radiation protection in the service operations, as observed through the inspection programs and analyses carried out by the General Inspectorate in 2007. Having been submitted to the group's Supervisory Board, this report is sent to the bodies representing the personnel. Content: 1 - A look back at 2007 by the AREVA General Inspector: Visible progress in 2007, Implementation of the Nuclear Safety Charter, Notable events; 2 - Status of nuclear safety and radiation protection in the nuclear facilities and service operations: Personnel radiation protection, Event tracking, Service operations, Criticality control, Radioactive waste and effluent management; 3 - Performance improvement actions; 4 - Description of the General Inspectorate; 5 - Glossary.

  9. Status of India's population education programme--the subject of tripartite projects review and annual country review.

    Science.gov (United States)

    1981-12-01

    A 3-step monitoring of India's population education program was undertaken in 1981 in order to determine the level of implementation and progress of the program. This monitoring program, conducted by the Unesco Mobile Team in collaboration with other institutions, followed 3 procedures: Project Progress Report (PPR); Tripartite Project Review (TPR); and Annual Country Review (ACR). The review meetings of the 10 state population education projects were organized at Chandigarh and Madras during August. The states covered in the review were Bihar, Haryana, Madhaya Pradesh, Punjab, Rajasthan, Chandigarh, Gujarat, Karnataka, Maharashtra, and Tamil Nadu. The Tripartite Review identified the following as problems which were hindering the smooth implementation of the population education program: 1) difficulty in spending funds unless certain formalities were completed by the governments of the states; 2) administrative problems such as getting printing paper for instructional materials, waiving the sales tax for equipment to be purchased under the project, and uncertainty regarding the admissible rates of per diem to be paid to the participants in various training programs; 3) the lack of experience of project staff; 4) problems created by having more than 1 cell in a state such as Rajasthan; and 5) an inadequate time frame within which the project should complete all its activities and make population education an integral part of the school system. The following were among the recommendations made: 1) the Project should be made coterminous with the 6th Five-Year Plan up to March 31, 1985; and 2) there should be only 1 Population Education Cell in every state. Among the points discussed at the annual country review, held during October, were the following: rephasing of the program from a 3 to 5 year project to synchronize it with the 6th plan; and the need for additional funds in view of inflation.

  10. Biallelic inactivation of REV7 is associated with Fanconi anemia.

    Science.gov (United States)

    Bluteau, Dominique; Masliah-Planchon, Julien; Clairmont, Connor; Rousseau, Alix; Ceccaldi, Raphael; Dubois d'Enghien, Catherine; Bluteau, Olivier; Cuccuini, Wendy; Gachet, Stéphanie; Peffault de Latour, Régis; Leblanc, Thierry; Socié, Gérard; Baruchel, André; Stoppa-Lyonnet, Dominique; D'Andrea, Alan D; Soulier, Jean

    2016-09-01

    Fanconi anemia (FA) is a recessive genetic disease characterized by congenital abnormalities, chromosome instability, progressive bone marrow failure (BMF), and a strong predisposition to cancer. Twenty FA genes have been identified, and the FANC proteins they encode cooperate in a common pathway that regulates DNA crosslink repair and replication fork stability. We identified a child with severe BMF who harbored biallelic inactivating mutations of the translesion DNA synthesis (TLS) gene REV7 (also known as MAD2L2), which encodes the mutant REV7 protein REV7-V85E. Patient-derived cells demonstrated an extended FA phenotype, which included increased chromosome breaks and G2/M accumulation upon exposure to DNA crosslinking agents, γH2AX and 53BP1 foci accumulation, and enhanced p53/p21 activation relative to cells derived from healthy patients. Expression of WT REV7 restored normal cellular and functional phenotypes in the patient's cells, and CRISPR/Cas9 inactivation of REV7 in a non-FA human cell line produced an FA phenotype. Finally, silencing Rev7 in primary hematopoietic cells impaired progenitor function, suggesting that the DNA repair defect underlies the development of BMF in FA. Taken together, our genetic and functional analyses identified REV7 as a previously undescribed FA gene, which we term FANCV.

  11. Analysis of translesion DNA synthesis activity of the human REV1-REV7 complex, which is a key player in radiation-induced mutagenesis

    International Nuclear Information System (INIS)

    Masuda, Y.; Masuda, K.; Kamiya, K.

    2003-01-01

    Full text: Ionizing radiation frequently causes oxidative DNA damage in cells. It has been suggested that functions of the REV1 and REV7 genes are induction of mutations and prevention of cell death caused by ionizing radiation. With yeast Saccharomyces cerevisiae, results from a variety of investigations have demonstrated that the REV genes play a major role in induction of mutations through replication processes which directly copy the damaged DNA template during DNA replication. However, in higher eucaryotes, functions of homologues are poorly understood and appear somewhat different from the yeast case. It has been suggested that human REV1 interacts with human REV7, this being specific to higher eucaryotes. Here we show that purified human REV1 and REV7 proteins form a heterodimer in solution, which is stable through intensive purification steps. Results from biochemical analysis of the transferase reactions of the REV1-REV7 complex demonstrated, in contrast to the case of yeast Rev3 whose polymerase activity is stimulated by assembly with yeast Rev7, that human REV7 did not influence the stability, substrate specificity or kinetic parameters of the transferase reactions of REV1 protein. A possible molecular role of the REV7 subunit may be to help assembly of the REV1 protein to a large complex containing REV3 and/or other DNA polymerases in higher eucaryotes

  12. Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging

    International Nuclear Information System (INIS)

    Wolff, Horst; Hadian, Kamyar; Ziegler, Manja; Weierich, Claudia; Kramer-Hammerle, Susanne; Kleinschmidt, Andrea; Erfle, Volker; Brack-Werner, Ruth

    2006-01-01

    The human immunodeficiency virus Rev protein is a post-transcriptional activator of HIV gene expression. Rev is a nucleocytoplasmic shuttle protein that displays characteristic nuclear/nucleolar subcellular localization in various cell lines. Cytoplasmic localization of Rev occurs under various conditions disrupting Rev function. The goal of this study was to investigate the relationship between localization of Rev and its functional activity in living cells. A triple-fluorescent imaging assay, called AQ-FIND, was established for automatic quantitative evaluation of nucleocytoplasmic distribution of fluorescently tagged proteins. This assay was used to screen 500 rev genes generated by error-prone PCR for Rev mutants with different localization phenotypes. Activities of the Rev mutants were determined with a second quantitative, dual-fluorescent reporter assay. In HeLa cells, the majority of nuclear Rev mutants had activities similar to wild-type Rev. The activities of Rev mutants with abnormal cytoplasmic localization ranged from moderately impaired to nonfunctional. There was no linear correlation between subcellular distribution and levels of Rev activity. In astrocytes, nuclear Rev mutants showed similar impaired activities as the cytoplasmic wild-type Rev. Our data suggest that steady-state subcellular localization is not a primary regulator of Rev activity but may change as a secondary consequence of altered Rev function. The methodologies described here have potential for studying the significance of subcellular localization for functions of other regulatory factors

  13. Lake Roosevelt Fisheries Evaluation Program, Part A; Fisheries Creel Survey and Population Status Analysis, 1998 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Spotts, Jim; Shields, John; Underwood, Keith

    2002-05-01

    The Lake Roosevelt Fisheries Evaluation Program is the result of a merger between two projects, the Lake Roosevelt Monitoring Program (BPA No. 8806300) and the Lake Roosevelt Data Collection Project (BPA No. 9404300). These projects were merged in 1996 to continue work historically completed under the separate projects, and is now referred to as the Lake Roosevelt Fisheries Evaluation Program. Creel and angler surveys estimated that anglers made 196,775 trips to Lake Roosevelt during 1998, with an economic value of $8.0 million dollars, based on the Consumer Price Index (CPI). In 1998 it was estimated that 9,980 kokanee salmon, 226,809 rainbow trout, 119,346 walleye, and over 14,000 smallmouth bass and other species were harvested. Creel data indicates that hatchery reared rainbow trout contribute substantially to the Lake Roosevelt fishery. The contribution of kokanee salmon to the creel has not met the expectations of fishery managers to date, and is limited by entrainment from the reservoir, predation, and possible fish culture obstacles. The 1998 Lake Roosevelt Fisheries Creel and Population Analysis Annual Report includes analyses of the relative abundance of fish species, and reservoir habitat relationships (1990-1998). Fisheries surveys (1990-1998) indicate that walleye and burbot populations appear to be increasing, while yellow perch, a preferred walleye prey species, and other prey species are decreasing in abundance. The long term decreasing abundance of yellow perch and other prey species are suspected to be the result of the lack of suitable multiple reservoir elevation spawning and rearing refugia for spring spawning reservoir prey species, resulting from seasonal spring-early summer reservoir elevation manipulations, and walleye predation. Reservoir water management is both directly, and indirectly influencing the success of mitigation hatchery production of kokanee salmon and rainbow trout. Tag return data suggested excessive entrainment occurred in

  14. Wave power plant at Horns Rev. Screening[Denmark]; Boelgekraftanlaeg ved Horns Rev. Screening

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, Hans C.; Nielsen, Kim; Steenstrup, P.R.; Friis-Madsen, E.; Wigant, L.

    2005-12-15

    The objective for the analysis has been to establish data for the sea at Horns Rev wind farm in the North Sea in order to assess the opportunity for using the site as test site for demonstration of wave energy devices exemplified by three different devices under development in Denmark. For comparison alternative sites like Hanstholm, Samsoe and Nissum Bredning are also assessed as well as the test centre EMEC at the Orkney Islands and the proposed test site Wave Hub at the north coast of Cornwall. The analysis shows that it is possible without major technical problems to connect 2-4 MW power generated by 3 different wave energy devices (AquaBuOY, Wave Star Energy and Wave Dragon) to the wind farm at Horns Rev (www.hornsrev.dk). The expenses for connection and regulation within the wind farm is about 200,000 DKK (30,00 EURO). On top of this comes the cost for individual sub sea cable connection to the wave devices, pull in of the sub sea cable through the existing J-tube in turbine T04 and the necessary regulation/control system in the individual wave devices to avoid damaging the power system in case of too high production. The analysis of the co-production of wind and wave power is dealt with in a separate report which shows that over a time period of half to one hour the time variation for wind generated electricity is 3 times as large as for wave energy generated power based on the actual measurement at Horns Rev. Further on the analysis shows that the wave generated power is more predictable than wind energy generated power as the power from the waves first is present about 2 hours after the wind is acting and last for 3 to 6 hours after the wind dies out; 6 to 12 hours with wind from west. The time is off course strongly depending of the direction of the wind i.e. the fetch. As this special report has a more general scope than the analysis as such it is reported in English (Annex Report II). The analysis shows that it is up to the individual device developer

  15. Kokanee Stock Status and Contribution of Cabinet Gorge Hatchery, Lake Pend Oreille, Idaho, 1985 Annual Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Bowles, Edward C.

    1986-07-01

    Mid-water trawling techniques were used during September to estimate kokanee population abundance, structure and survival. Abundance in 1985 was estimated at 4.5 million fish (198 per hectare), down from over 12 million kokanee in 1974 when the population was first monitored. Hatchery fry production (<6 million annually) has stabilized kokanee abundance since its initial decline in the late 1960s. Wild fry recruitment has remained relatively stable at 1.8 million since 1978; whereas recruitment of hatchery-reared fry has ranged from 0.09 to 1.98 million. The 1985 creel survey indicated that kokanee harvest rates remain low, with approximately one kokanee harvested per hour of effort from April to August. Catch rates were as high as 3.5 fish per hour during the mid-1960s. The zooplankton community was monitored with periodic plankton tows. Zooplankton composition in 1985 was similar to previous years and appears to have stabilized following the introduction of mysids, with peak cladoceran production occurring several weeks after peak kokanee emergence. Delayed release of hatchery fry resulted in higher survival of hatchery (7.3%) than wild (0.43%) kokanee fry. Other release strategies will be tested as more fry become available.

  16. Administrative Circular No. 30 (Rev. 3) - “Financial benefits on taking up appointment and on termination of contract”

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 30 (Rev. 3) entitled “Financial benefits on taking up appointment and on termination of contract”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, is available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 30 (Rev. 3) is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 30 (Rev. 2/Corr.) entitled "Financial benefits on taking up appointment and on termination of contract” of September 2009. This circular was revised in order to implement the modifications introduced into the Staff Rules and Regulations in January 2013 relating to the introduction of the status of Associate Member States and new categories of associated members of the personnel. In particular, the notion of “Member State” in Annexe II (&a...

  17. Administrative Circular N° 26 (Rev.  5) - November 2004

    CERN Multimedia

    Human Resources Department

    2004-01-01

    Procedure governing the career evolution of staff members The introduction of an electronic individual appraisal report form via EDH for the MAPS exercise entails some modifications to Administrative Circular N° 26 (Rev. 4). The revised version (Rev. 5) is available in departmental secretariats as well as on the Web at the following address: http://cern.ch/hr-web/internal/admin_services/admincirc/listadmincirc.asp Human Resources Department Tel. 74128

  18. Altered Sleep Homeostasis in Rev-erbα Knockout Mice.

    Science.gov (United States)

    Mang, Géraldine M; La Spada, Francesco; Emmenegger, Yann; Chappuis, Sylvie; Ripperger, Jürgen A; Albrecht, Urs; Franken, Paul

    2016-03-01

    The nuclear receptor REV-ERBα is a potent, constitutive transcriptional repressor critical for the regulation of key circadian and metabolic genes. Recently, REV-ERBα's involvement in learning, neurogenesis, mood, and dopamine turnover was demonstrated suggesting a specific role in central nervous system functioning. We have previously shown that the brain expression of several core clock genes, including Rev-erbα, is modulated by sleep loss. We here test the consequences of a loss of REV-ERBα on the homeostatic regulation of sleep. EEG/EMG signals were recorded in Rev-erbα knockout (KO) mice and their wild type (WT) littermates during baseline, sleep deprivation, and recovery. Cortical gene expression measurements after sleep deprivation were contrasted to baseline. Although baseline sleep/wake duration was remarkably similar, KO mice showed an advance of the sleep/wake distribution relative to the light-dark cycle. After sleep onset in baseline and after sleep deprivation, both EEG delta power (1-4 Hz) and sleep consolidation were reduced in KO mice indicating a slower increase of homeostatic sleep need during wakefulness. This slower increase might relate to the smaller increase in theta and gamma power observed in the waking EEG prior to sleep onset under both conditions. Indeed, the increased theta activity during wakefulness predicted delta power in subsequent NREM sleep. Lack of Rev-erbα increased Bmal1, Npas2, Clock, and Fabp7 expression, confirming the direct regulation of these genes by REV-ERBα also in the brain. Our results add further proof to the notion that clock genes are involved in sleep homeostasis. Because accumulating evidence directly links REV-ERBα to dopamine signaling the altered homeostatic regulation of sleep reported here are discussed in that context. © 2016 Associated Professional Sleep Societies, LLC.

  19. Performance appraisal and advancement exercise 2006 (Rev)

    CERN Multimedia

    Human Resources Department

    2005-01-01

    The 2006 performance appraisal and advancement exercise will start in the usual way with annual interviews between staff and their supervisors. This year, these interviews should be held in the period from 1 December 2005 to 15 March 2006*. In this connection, a number of improvements to the procedures relating to the interviews and performance appraisals are currently under study. Administrative Circular No. 26 (Procedures Governing the Career Development of Staff Members) and the electronic MAPS form in EDH are being reviewed and will be available from December onwards. In the meantime supervisors can start the interview procedure. HR Department will shortly provide further information on this subject. The 2005 MAPS report can be retrieved for consultation at any time via EDH. * Instead of 31 March, as indicated in the electronic Bulletin No. 47 of 21 November 2005 Human Resources Department Tel. 73566

  20. ASC FY17 Implementation Plan, Rev. 1

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, P. G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-06-14

    The Stockpile Stewardship Program (SSP) is an integrated technical program for maintaining the safety, surety, and reliability of the U.S. nuclear stockpile. The SSP uses nuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program requires the continued use of experimental facilities and programs, and the computational capabilities to support these programs. The Advanced Simulation and Computing Program (ASC) is a cornerstone of the SSP, providing simulation capabilities and computational resources that support annual stockpile assessment and certification, study advanced nuclear weapons design and manufacturing processes, analyze accident scenarios and weapons aging, and provide the tools to enable stockpile Life Extension Programs (LEPs) and the resolution of Significant Finding Investigations (SFIs). This requires a balance of resources, including technical staff, hardware, simulation software, and computer science solutions.

  1. Energy from agricultural animal wastes. Rev. ed.

    International Nuclear Information System (INIS)

    1994-12-01

    This technology status report discusses the production of animal wastes in the UK, and the environmental problems caused by direct use of the waste as fertilisers or disposal by landfilling. The effects of the moisture content of the waste on the choice of technology is examined, and the use of anaerobic digestion for wetter wastes to produce biogas and combustion of dryer wastes to produce heat, power and phosphate- and potash-rich ash are discussed. Market opportunities, and the economics and environmental impacts of both technologies are investigated

  2. Status of safety at Areva group facilities. 2006 annual report; Etat de surete des installations nucleaires. Rapport annuel 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This report presents a snapshot of nuclear safety and radiation protection conditions in the AREVA group's nuclear installations in France and abroad, as well as of radiation protection aspects in service activities, as identified over the course of the annual inspections and analyses program carried out by the General Inspectorate in 2006. This report is presented to the AREVA Supervisory Board, communicated to the labor representation bodies concerned, and made public. In light of the inspections, appraisals and coordination missions it has performed, the General Inspectorate considers that the nuclear safety level of the AREVA group's nuclear installations is satisfactory. It particularly noted positive changes on numerous sites and efforts in the field of continuous improvement that have helped to strengthen nuclear safety. This has been possible through the full involvement of management teams, an improvement effort initiated by upper management, actions to increase personnel awareness of nuclear safety culture, and supervisors' heightened presence around operators. However, the occurrence of certain events in facilities has led us to question the nuclear safety repercussions that the changes to activities or organization on some sites have had. In these times of change, drifts in nuclear safety culture have been identified. The General Inspectorate considers that a preliminary analysis of the human and organizational factors of these changes, sized to match the impact the change has on nuclear safety, should be made to ensure that a guaranteed level of nuclear safety is maintained (allowance for changes to references, availability of the necessary skills, resources of the operating and support structures, etc.). Preparations should also be made to monitor the changes and spot any telltale signs of drift in the application phase. Managers should be extra vigilant and the occurrence of any drift should be systematically dealt with ahead of

  3. Reference Model 2: "Rev 0" Rotor Design

    Energy Technology Data Exchange (ETDEWEB)

    Barone, Matthew F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Berg, Jonathan Charles [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Griffith, Daniel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2011-12-01

    The preliminary design for a three-bladed cross-flow rotor for a reference marine hydrokinetic turbine is presented. A rotor performance design code is described, along with modifications to the code to allow prediction of blade support strut drag as well as interference between two counter-rotating rotors. The rotor is designed to operate in a reference site corresponding to a riverine environment. Basic rotor performance and rigid-body loads calculations are performed to size the rotor elements and select the operating speed range. The preliminary design is verified with a simple finite element model that provides estimates of bending stresses during operation. A concept for joining the blades and support struts is developed and analyzed with a separate finite element analysis. Rotor mass, production costs, and annual energy capture are estimated in order to allow calculations of system cost-of-energy. Evaluation Only. Created with Aspose.Pdf.Kit. Copyright 2002-2011 Aspose Pty Ltd Evaluation Only. Created with Aspose.Pdf.Kit. Copyright 2002-2011 Aspose Pty Ltd

  4. Annual status report on Federal Facility Agreement compliance for the Liquid Low-Level Waste tank systems at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    1994-09-01

    This annual report summarizes the status of Federal Facility Agreement (FFA) compliance activities at Oak Ridge National Laboratory (ORNL) and describes the progress made over the past fiscal year. In fiscal 1994, ORNL issued the final submittal of the risk characterization data for the inactive tanks, the secondary containment design demonstration report for Category B piping, and the FFA Implementation Plan. In addition, two new LLLW tanks serving Building 2026 and the Transported Waste Receiving Facility were installed; leak testing was initiated for all active, singly contained tanks and piping; sources of inflow to inactive tanks were investigated and diversion to process waste was begun; and the W-12 tank system was repaired and a request to allow its temporary use was approved by EPA/TDEC. Programmatic improvements were also made during the year: a system for improved communication of FFA plans and activities was implemented in October 1993, a survey was conducted to ensure that all inactive drains are identified and sealed, and two meetings of the ORNL FFA Technical Advisory Group were held

  5. Binding and thermodynamics of REV peptide-ctDNA interaction.

    Science.gov (United States)

    Upadhyay, Santosh Kumar

    2017-03-01

    The thermodynamics of DNA-ligand binding is important as it provides useful information to understand the details of binding processes. HIV-1 REV response element (RRE) located in the env coding region of the viral genome is reported to be well conserved across different HIV-1 isolates. In this study, the binding characteristics of Calf thymus DNA (ctDNA) and REV peptide from HIV-1 were investigated using spectroscopic (UV-visible, fluorescence, and circular dichroism (CD)) and isothermal titration calorimetric (ITC) techniques. Thermal stability and ligand binding properties of the ctDNA revealed that native ctDNA had a T m of 75.5 °C, whereas the ctDNA-REV peptide complex exhibited an incremental shift in the T m by 8 °C, indicating thermal stability of the complex. CD data indicated increased ellipticity due to large conformational changes in ctDNA molecule upon binding with REV peptide and two binding stoichiometric modes are apparent. The ctDNA experienced condensation due to large conformational changes in the presence of REV peptide and positive B→Ψ transition was observed at higher molar charge ratios. Fluorescence studies performed at several ligand concentrations revealed a gradual decrease in the fluorescence intensity of EtBr-bound ctDNA in response to increasing ligand concentrations. The fluorescence data further confirmed two stoichiometric modes of binding for ctDNA-REV peptide complex as previously observed with CD studies. The binding enthalpies were determined using ITC in the temperature range of 293 K-308 K. The ITC binding isotherm was exothermic at all temperatures examined, with low ΔH values indicating that the ctDNA-REV peptide interaction is driven largely by entropy. The heat capacity change (ΔC p ) was insignificant, an unusual finding in the area of DNA-peptide interaction studies. The variation in the values obtained for ΔH, ΔS, and ΔG with temperature further suggests that ctDNA-REV peptide interaction is entropically

  6. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import.

    LENUS (Irish Health Repository)

    Gu, Lili

    2011-01-01

    The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised.

  7. Administrative Circular No. 26 (Rev. 7) – May 2007

    CERN Multimedia

    HR Department

    2007-01-01

    Recognition of Merit of Staff Members Administrative Circular No. 26 (Rev. 7) is now available on the intranet site of the Human Resources Department. This circular cancels and replaces Administrative Circular No. 26 (Rev. 6) - Procedures governing the career development of staff members. Copies will shortly be available in Departmental secretariats. If you require any additional information on the new staff-member merit assessment and recognition system, you may consult the FAQ, which has been available on the Human Resources Department intranet site since February 2007. Human Resources Department Tel. 78003

  8. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import.

    LENUS (Irish Health Repository)

    Gu, Lili

    2011-03-14

    Abstract Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised. Results In our study, we have identified the cellular protein HIC (Human I-mfa domain-Containing protein) as a novel interactor of HIV-1 Rev. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin β and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. Hence, the molecular determinants mediating Rev-NLS recognition by importin β and transportin appear to be distinct. Furthermore, we have employed HIC and M9 M, a peptide specifically designed to inhibit the transportin-mediated nuclear import pathway, to characterise Rev nuclear import pathways within different cellular environments. Remarkably, we could show that in 293T, HeLa, COS7, Jurkat, U937, THP-1 and CEM cells, Rev nuclear import is cell type specific and alternatively mediated by transportin or importin β, in a mutually exclusive fashion. Conclusions Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.

  9. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import

    Directory of Open Access Journals (Sweden)

    Sheehy Noreen

    2011-03-01

    Full Text Available Abstract Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised. Results In our study, we have identified the cellular protein HIC (Human I-mfa domain-Containing protein as a novel interactor of HIV-1 Rev. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin β and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. Hence, the molecular determinants mediating Rev-NLS recognition by importin β and transportin appear to be distinct. Furthermore, we have employed HIC and M9 M, a peptide specifically designed to inhibit the transportin-mediated nuclear import pathway, to characterise Rev nuclear import pathways within different cellular environments. Remarkably, we could show that in 293T, HeLa, COS7, Jurkat, U937, THP-1 and CEM cells, Rev nuclear import is cell type specific and alternatively mediated by transportin or importin β, in a mutually exclusive fashion. Conclusions Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.

  10. Status of national programmes on fast breeder reactors. Twenty-fifth annual meeting of the International Working Group on Fast Reactors. Summary report. Working material

    International Nuclear Information System (INIS)

    1992-01-01

    'burning' of the associated extremely long-life transuranic waste, particularly actinides, thus reducing the required isolation time for high level waste from tens of thousands of years to hundreds of years for fission products only. This additional important mission for the LMFBR is gaining worldwide interest. In the framework of disarmament of nuclear weapons and the utilization of the nuclear material for peaceful purposes a role for fast reactors can be also considered. Over the past 25 years, the IAEA has actively encouraged and advocated international cooperation in Fast Breeder Reactor Technology. At the present time the Working Group on Fast Reactors is the oldest and one of the most active groups in the Division of Nuclear Power. The present document contains information on the status of fast breeder reactor development and on worldwide activities in this advanced nuclear power technology during 1991, as reported at the 25th jubilee Annual Meeting of the IWGFR in Vienna, 27-30 April 1992. The publication is intended to provide information regarding the current status of LMFBR development in IAEA Member States and CEC

  11. Status of national programmes on fast breeder reactors. Twenty-fifth annual meeting of the International Working Group on Fast Reactors. Summary report. Working material

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-07-01

    'burning' of the associated extremely long-life transuranic waste, particularly actinides, thus reducing the required isolation time for high level waste from tens of thousands of years to hundreds of years for fission products only. This additional important mission for the LMFBR is gaining worldwide interest. In the framework of disarmament of nuclear weapons and the utilization of the nuclear material for peaceful purposes a role for fast reactors can be also considered. Over the past 25 years, the IAEA has actively encouraged and advocated international cooperation in Fast Breeder Reactor Technology. At the present time the Working Group on Fast Reactors is the oldest and one of the most active groups in the Division of Nuclear Power. The present document contains information on the status of fast breeder reactor development and on worldwide activities in this advanced nuclear power technology during 1991, as reported at the 25th jubilee Annual Meeting of the IWGFR in Vienna, 27-30 April 1992. The publication is intended to provide information regarding the current status of LMFBR development in IAEA Member States and CEC.

  12. A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev

    International Nuclear Information System (INIS)

    Fang Jianhua; Kubota, Satoshi; Yang Bin; Zhou Naiming; Zhang Hui; Godbout, Roseline; Pomerantz, Roger J.

    2004-01-01

    HIV-1 Rev escorts unspliced viral mRNAs out of the nucleus of infected cells, which allows formation of infectious HIV-1 virions. We have identified a putative DEAD box (Asp-Glu-Ala-Asp) RNA helicase, DDX1, as a cellular co-factor of Rev, through yeast and mammalian two-hybrid systems using the N-terminal motif of Rev as 'bait'. DDX1 is not a functional homolog of HIV-1 Rev, but down-regulation of DDX1 resulted in an alternative splicing pattern of Rev-responsive element (RRE)-containing mRNA, and attenuation of Gag p24 antigen production from HLfb rev(-) cells rescued by exogenous Rev. Co-transfection of a DDX1 expression vector with HIV-1 significantly increased viral production. DDX1 binding to Rev, as well as to the RRE, strongly suggest that DDX1 affects Rev function through the Rev-RRE axis. Moreover, down-regulation of DDX1 altered the steady state subcellular distribution of Rev, from nuclear/nucleolar to cytoplasmic dominance. These findings indicate that DDX1 is a critical cellular co-factor for Rev function, which maintains the proper subcellular distribution of this lentiviral regulatory protein. Therefore, alterations in DDX1-Rev interactions could induce HIV-1 persistence and targeting DDX1 may lead to rationally designed and novel anti-HIV-1 strategies and therapeutics

  13. Administrative circular n°3 (Rev. 2) – Home leave, travel to home station and assimilated leave and travel

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 3 (Rev. 2) entitled “Home leave, travel to the home station and assimilated leave and travel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 October 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to employed members of the personnel. It cancels and replaces Administrative Circular No. 3 (Rev. 1) entitled “Travel to the home station and home leave” of June 2002. The circular was revised in order to take into account the new status of Associate Member State and the fact that henceforth, home stations may be situated on territory outside of Europe. It is proposed to introduce a new system of determination of the benefits (Travel expenses, travel time and distance indemnity) granted in the context of home leave and supplementary journeys to the home station.  For t...

  14. Operational circular No. 1 (Rev. 1) – Operational circulars

    CERN Multimedia

    HR Department

    2011-01-01

    Operational Circular No. 1 (Rev. 1) is applicable to members of the personnel and other persons concerned. Operational Circular No. 1 (Rev. 1) entitled "Operational circulars", approved following discussion at the Standing Concertation Committee meeting on 4 May 2011, is available on the intranet site of the Human Resources Department: https://hr-docs.web.cern.ch/hr-docs/opcirc/opcirc.asp It cancels and replaces Operational Circular No. 1 entitled "Operational Circulars” of December 1996. This new version clarifies, in particular, that operational circulars do not necessarily arise from the Staff Rules and Regulations, and the functional titles have been updated to bring them into line with the current CERN organigram. Department Head Office  

  15. Administrative Circular No. 26 (Rev.10) - Recognition of merit

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 26 (Rev. 10) entitled “Recognition of Merit”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to staff members. It cancels and replaces Administrative Circular No. 26 (Rev. 9) entitled “Recognition of Merit” of December 2011. The circular was revised in order to take into account the work performed in the framework of an elective mandate during the exercise of merit recognition of staff members. In addition, the circular was revised to provide that, in the case of staff members on special leave for professional reasons for a period equal to or longer than half a year, it will no longer be possible to grant an exceptional advancement. Department Head Office HR Department

  16. Administrative Circular No. 23 (Rev. 4) - Special working hours

    CERN Document Server

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 23 (Rev. 4) entitled "Special working hours", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208539.   This revised circular cancels and replaces Administrative Circular No. 23 (Rev. 3) also entitled "Special working hours" of January 2013. This document contains modifications to reflect the new career structure and ensuring the provision consistent with practice that compensation or remuneration of special working hours performed remotely is possible only in case of emergency.   This circular will enter into force on 1st September 2016.

  17. Meteorological explanation of wake clouds at Horns Rev wind farm

    Energy Technology Data Exchange (ETDEWEB)

    Emeis, S. [Karlsruhe Institute of Technology (Germany). Inst. for Meteorology and Climate Research

    2010-08-15

    The occurrence of wake clouds at Horns Rev wind farm is explained as mixing fog. Mixing fog forms when two nearly saturated air masses with different temperature are mixed. Due to the non-linearity of the dependence of the saturation water vapour pressure on temperature, the mixed air mass is over-saturated and condensation sets in. On the day in February 2008, when the wake clouds were observed at Horns Rev, cold and very humid air was advected from the nearby land over the warmer North Sea and led to the formation of a shallow layer with sea smoke or fog close above the sea surface. The turbines mixed a much deeper layer and thus provoked the formation of cloud trails in the wakes of the turbines. (orig.)

  18. REV-ERB and ROR: therapeutic targets for treating myopathies

    Science.gov (United States)

    Welch, Ryan D.; Flaveny, Colin A.

    2017-08-01

    Muscle is primarily known for its mechanical roles in locomotion, maintenance of posture, and regulation of cardiac and respiratory function. There are numerous medical conditions that adversely affect muscle, myopathies that disrupt muscle development, regeneration and protein turnover to detrimental effect. Skeletal muscle is also a vital secretory organ that regulates thermogenesis, inflammatory signaling and directs context specific global metabolic changes in energy substrate preference on a daily basis. Myopathies differ in the causative factors that drive them but share common features including severe reduction in quality of life and significantly increased mortality all due irrefutably to the loss of muscle mass. Thus far clinically viable approaches for preserving muscle proteins and stimulating new muscle growth without unwanted side effects or limited efficacy has been elusive. Over the last few decades, evidence has emerged through in vitro and in vivo studies that suggest the nuclear receptors REV-ERB and ROR might modulate pathways involved in myogenesis and mitochondrial biogenesis. Hinting that REV-ERB and ROR might be targeted to treat myopathies. However there is still a need for substantial investigation into the roles of these nuclear receptors in in vivo rodent models of degenerative muscle diseases and acute injury. Although exciting, REV-ERB and ROR have somewhat confounding roles in muscle physiology and therefore more studies utilizing in vivo models of skeletal muscle myopathies are needed. In this review we highlight the molecular forces driving some of the major degenerative muscular diseases and showcase two promising molecular targets that may have the potential to treat myopathies: ROR and REV-ERB.

  19. ENDF/B-5 Fission Products Library. Rev. 2

    International Nuclear Information System (INIS)

    Schwerer, O.; Pronyaev, V.G.; Lemmel, H.D.

    1984-07-01

    This document summarizes contents and documentation of the 1984 version of the Fission Products Nuclear Data File of the ENDF/B-5 Library (Rev. 2) maintained by the National Nuclear Data Center (NNDC) at the Brookhaven National Laboratory, USA. This file contains numerical neutron reaction data and decay data for 877 fission product nuclides. The entire file or selective retrievals from it can be obtained on magnetic tape from the IAEA Nuclear Data Section. (author)

  20. Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export.

    Science.gov (United States)

    Behrens, Ryan T; Aligeti, Mounavya; Pocock, Ginger M; Higgins, Christina A; Sherer, Nathan M

    2017-02-01

    HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of modulating Rev NES identity, number, position, or strength on Rev subcellular trafficking, viral RNA nuclear export, and infectious virion production. We found that Rev activity was remarkably tolerant of diverse NES sequences, including supraphysiological NES (SNES) peptides that otherwise arrest CRM1 transport complexes at nuclear pores. Rev's ability to tolerate a SNES was both position and multimerization dependent, an observation consistent with a model wherein Rev self-association acts to transiently mask the NES peptide(s), thereby biasing Rev's trafficking into the nucleus. Combined imaging and functional assays also indicated that NES masking underpins Rev's well-known tendency to accumulate at the nucleolus, as well as Rev's capacity to activate optimal levels of late viral gene expression. We propose that Rev multimerization and NES masking regulates Rev's trafficking to and retention within the nucleus even prior to RNA binding. HIV-1 infects more than 34 million people worldwide causing >1 million deaths per year. Infectious virion production is activated by the essential viral Rev protein that mediates nuclear export of intron-bearing late-stage viral mRNAs. Rev's shuttling into and out of the nucleus is regulated by the antagonistic activities of both a peptide-encoded N-terminal nuclear localization signal and C-terminal nuclear export signal (NES). How Rev and related viral proteins balance strong import and export activities in order to achieve optimal levels of viral gene expression is incompletely understood. We provide evidence that multimerization provides a mechanism by which Rev transiently masks its NES peptide

  1. Administrative Circulars No. 12 A (Rev. 2) - "Education fees” and No. 12 B (Rev. 2) - “Education fees and language courses”

    CERN Multimedia

    2013-01-01

    Administrative Circulars No. 12 A (Rev. 2) entitled “Education fees” and No. 12 B (Rev. 2) entitled “Education fees and language courses”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, are available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 12 A (Rev. 2) is applicable to Staff Members (except former “Local Staff Members”) recruited before 1st January 2007. Administrative Circular No. 12 B (Rev. 2) is applicable to Staff Members recruited on or after 1st January 2007, to Fellows, to Scientific Associates, to Guest Professors and to former “Local Staff” recruited before 1st January 2007. They cancel and replace Administrative Circulars No. 12 A (Rev. 1/Corr.) entitled "Education fees” and No. 12 B (Rev. 1/Corr.) entitled “Edu...

  2. Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.

    Science.gov (United States)

    Bogerd, H P; Wiegand, H L; Yang, J; Cullen, B R

    2000-10-01

    Nuclear export of the incompletely spliced mRNAs encoded by several complex retroviruses, including human immunodeficiency virus type 1 (HIV-1), is dependent on a virally encoded adapter protein, termed Rev in HIV-1, that directly binds both to a cis-acting viral RNA target site and to the cellular Crm1 export factor. Human endogenous retrovirus K, a family of ancient endogenous retroviruses that is not related to the exogenous retrovirus HIV-1, was recently shown to also encode a Crm1-dependent nuclear RNA export factor, termed K-Rev. Although HIV-1 Rev and K-Rev display little sequence identity, they share the ability not only to bind to Crm1 and to RNA but also to form homomultimers and shuttle between nucleus and cytoplasm. We have used mutational analysis to identify sequences in the 105-amino-acid K-Rev protein required for each of these distinct biological activities. While mutations in K-Rev that inactivate any one of these properties also blocked K-Rev-dependent nuclear RNA export, several K-Rev mutants were comparable to wild type when assayed for any of these individual activities yet nevertheless defective for RNA export. Although several nonfunctional K-Rev mutants acted as dominant negative inhibitors of K-Rev-, but not HIV-1 Rev-, dependent RNA export, these were not defined by their inability to bind to Crm1, as is seen with HIV-1 Rev. In total, this analysis suggests a functional architecture for K-Rev that is similar to, but distinct from, that described for HIV-1 Rev and raises the possibility that viral RNA export mediated by the approximately 25 million-year-old K-Rev protein may require an additional cellular cofactor that is not required for HIV-1 Rev function.

  3. UV-induced reversion of his4 frameshift mutations in rad6, rev1, and rev3 mutants of yeast.

    Science.gov (United States)

    Lawrence, C W; O'Brien, T; Bond, J

    1984-01-01

    The UV-induced reversion of two his4 frameshift alleles was much reduced in rad6 mutants of Saccharomyces cerevisiae, an observation that is consistent with the hypothesis that RAD6 function is required for the induction of all types of genetic alteration in misrepair mutagenesis. The reversion of these his4 alleles, together with two others of the same type, was also reduced in rev1 and rev3 mutant strains; in these, however, the extent of the reduction varied considerably with test allele used, in a manner analogous to the results in these strains for base repair substitution test alleles. The general features of UV-induced frameshift and substitution mutagenesis therefore appear quite similar, indicating that they may depend on related processes. If this conclusion is correct, greater attention must be given to integrating models which account for the production of nucleotide additions and deletions into those concerning misrepair mutagenesis.

  4. Sampling and estimation techniques for the implementation of new classification systems: the change-over from NACE Rev. 1.1 to NACE Rev. 2 in business surveys

    Directory of Open Access Journals (Sweden)

    Jan van den Brakel

    2010-09-01

    Full Text Available This paper describes some of the methodological problems encountered with the change-over from the NACE Rev. 1.1 to the NACE Rev. 2 in business statistics. Different sampling and estimation strategies are proposed to produce reliable figures for the domains under both classifications simultaneously. Furthermore several methods are described that can be used to reconstruct time series for the domains under the NACE Rev. 2.

  5. Repository Surface Design Engineering Files Report Rev 00 ICN 1

    International Nuclear Information System (INIS)

    2001-01-01

    The objective of the Repository Surface Design Engineering Files Report Supplement [herein known as the Engineering Files (EF)] is to provide the surface design data needed by the Environmental Impact Statement (EIS) contractor to prepare the EIS and evaluate options and alternatives. This document is based on the Repository Surface Design Engineering Files Report, Revision 03 (CRWMS M and O 1999f) (EF Rev 03). Where facility and system designs have been changed for the Site Recommendation (SR) effort they are described in this report. EIS information provided in this report includes the following: (1) Description of program phases; there are no changes that impact this report. (2) A description of the major design requirements and assumptions that drive the surface facilities reference design is provided herein (Section 2.2), including the surface design resulting from recommendations regarding Enhanced Design Alternative (EDA) II, as discussed in the License Application Design Section Report (CRWMS M and O 1999d), and changes to the waste stream. See Section 2, Table 2-2, for the SR waste stream. (3) The major design requirements and assumptions that drive the surface facilities reference design are by reference to EF Rev 03; there are no changes that impact this report. (4) Description of the reference design concept and existing site conditions is by reference to EF Rev 03 (including Table 4-1, which is not included in this supplement); there are no changes that impact this report. (5) Description of alternative design cases is by reference to EF Rev 03; there are no changes that impact this report. (6) Description of optional inventory modules is by reference to EF Rev 03; there are no changes that impact this report. (7) Tabular summary level engineering values (i.e., staffing, wastes, emissions, resources, and land use) for the reference design and the alternative design cases that address construction, emplacement operations, caretaker operations, and

  6. Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas

    Science.gov (United States)

    New Hampshire Fleet Revs up With Natural Gas to someone by E-mail Share Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Facebook Tweet about Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Twitter Bookmark Alternative Fuels Data Center

  7. RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs

    International Nuclear Information System (INIS)

    Huang, Feng; Zhang, Junsong; Zhang, Yijun; Geng, Guannan; Liang, Juanran; Li, Yingniang; Chen, Jingliang; Liu, Chao; Zhang, Hui

    2015-01-01

    Human immunodeficiency virus type 1 (HIV-1) exploits multiple host factors during its replication. The REV/RRE-dependent nuclear export of unspliced/partially spliced viral transcripts needs the assistance of host proteins. Recent studies have shown that MOV10 overexpression inhibited HIV-1 replication at various steps. However, the endogenous MOV10 was required in certain step(s) of HIV-1 replication. In this report, we found that MOV10 potently enhances the nuclear export of viral mRNAs and subsequently increases the expression of Gag protein and other late products through affecting the Rev/RRE axis. The co-immunoprecipitation analysis indicated that MOV10 interacts with Rev in an RNA-independent manner. The DEAG-box of MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export and the DEAG-box mutant showed a dominant-negative activity. Our data propose that HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev and demonstrate the complicated effects of MOV10 on HIV-1 life cycle. - Highlights: • MOV10 can function as a co-factor of HIV-1 Rev. • MOV10 facilitates Rev/RRE-dependent transport of viral mRNAs. • MOV10 interacts with Rev in an RNA-independent manner. • The DEAG-box of MOV10 is required for the enhancement of Rev/RRE-dependent export.

  8. RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Feng; Zhang, Junsong; Zhang, Yijun; Geng, Guannan; Liang, Juanran; Li, Yingniang; Chen, Jingliang [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Liu, Chao, E-mail: liuchao9@mail.sysu.edu.cn [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Zhang, Hui [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China)

    2015-12-15

    Human immunodeficiency virus type 1 (HIV-1) exploits multiple host factors during its replication. The REV/RRE-dependent nuclear export of unspliced/partially spliced viral transcripts needs the assistance of host proteins. Recent studies have shown that MOV10 overexpression inhibited HIV-1 replication at various steps. However, the endogenous MOV10 was required in certain step(s) of HIV-1 replication. In this report, we found that MOV10 potently enhances the nuclear export of viral mRNAs and subsequently increases the expression of Gag protein and other late products through affecting the Rev/RRE axis. The co-immunoprecipitation analysis indicated that MOV10 interacts with Rev in an RNA-independent manner. The DEAG-box of MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export and the DEAG-box mutant showed a dominant-negative activity. Our data propose that HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev and demonstrate the complicated effects of MOV10 on HIV-1 life cycle. - Highlights: • MOV10 can function as a co-factor of HIV-1 Rev. • MOV10 facilitates Rev/RRE-dependent transport of viral mRNAs. • MOV10 interacts with Rev in an RNA-independent manner. • The DEAG-box of MOV10 is required for the enhancement of Rev/RRE-dependent export.

  9. Wind Farm Wake: The Horns Rev Photo Case

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Rasmussen, Leif; Peña, Alfredo

    2013-01-01

    The aim of the paper is to examine the nowadays well-known wind farm wake photographs taken on 12 February 2008 at the offshore Horns Rev 1 wind farm. The meteorological conditions are described from observations from several satellite sensors quantifying clouds, surface wind vectors and sea surf...... in the wake regions with relatively high axial velocities and high turbulent kinetic energy. The wind speed is near cut-in and most turbines produce very little power. The rotational pattern of spiraling bands produces the large-scale structure of the wake fog....

  10. Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.

    Directory of Open Access Journals (Sweden)

    Thomas Vercruysse

    Full Text Available HIV-1 Rev is the key protein in the nucleocytoplasmic export and expression of the late viral mRNAs. An important aspect for its function is its ability to multimerize on these mRNAs. We have recently identified a llama single-domain antibody (Nb190 as the first inhibitor targeting the Rev multimerization function in cells. This nanobody is a potent intracellular antibody that efficiently inhibits HIV-1 viral production. In order to gain insight into the Nb190-Rev interaction interface, we performed mutational and docking studies to map the interface between the nanobody paratope and the Rev epitope. Alanine mutants of the hyper-variable domains of Nb190 and the Rev multimerization domains were evaluated in different assays measuring Nb190-Rev interaction or viral production. Seven residues within Nb190 and five Rev residues are demonstrated to be crucial for epitope recognition. These experimental data were used to perform docking experiments and map the Nb190-Rev structural interface. This Nb190-Rev interaction model can guide further studies of the Nb190 effect on HIV-1 Rev function and could serve as starting point for the rational development of smaller entities binding to the Nb190 epitope, aimed at interfering with protein-protein interactions of the Rev N-terminal domain.

  11. Annual Status Report (FY2015) Performance Assessment for the Disposal of Low-Level Waste in the 200 West Area Burial Grounds

    Energy Technology Data Exchange (ETDEWEB)

    Khaleel, R. [INTERA, Inc., Austin, TX (United States); Mehta, S. [CH2M Hill Plateau Remediation Company, Richland, WA (United States); Nichols, W. E. [CH2M Hill Plateau Remediation Company, Richland, WA (United States)

    2016-02-01

    This annual review provides the projected dose estimates of radionuclide inventories disposed in the active 200 West Area Low-Level Burial Grounds (LLBGs) since September 26, 1988. These estimates area calculated using the original does methodology developed in the performance assessment (PA) analysis (WHC-EP-0645).

  12. Status of National Programmes on Fast Breeder Reactors. International Working Group on Fast Reactors Twenty-First Annual Meeting, Seattle, USA, 9-12 May 1988

    International Nuclear Information System (INIS)

    1988-11-01

    The following papers on the status of national programmes on fast breeder reactors are presented in this report: Fast breeder reactor development in France during 1987; Status of fast breeder reactor development in the Federal Republic of Germany, Belgium and the Netherlands; A review of the Indian fast reactor programme; A review of the Italian fast reactor programme; A review of the fast reactor programme in Japan; Status of fast reactor activities in the USSR; A review of the United Kingdom fast reactor programme; Status of liquid metal reactor development in the United States of America; Review of activities of the Commission of European Communities relating to fast reactors in 1987; European co-operation in the field of fast reactor research and development — 1987 progress report; A review of fast reactor activities in Switzerland

  13. Assessment of the current status of basic nuclear data compilations

    International Nuclear Information System (INIS)

    1985-01-01

    Topics discussed include: the status of mass-chain evaluations, remote terminal access, other US Nuclear Data Network publications, formats and procedures subcommittee report, keyword follow-up (Phys. Rev. C), and atomic data and nuclear data tables

  14. Renewables 2018 - Global status report. A comprehensive annual overview of the state of renewable energy. Advancing the global renewable energy transition - Highlights of the REN21 Renewables 2018 Global Status Report in perspective

    International Nuclear Information System (INIS)

    Sawin, Janet L.; Sverrisson, Freyr; Rutovitz, Jay; Dwyer, Scott; Teske, Sven; Murdock, Hannah E.; Adib, Rana; Guerra, Flavia; Murdock, Hannah E.; Blanning, Linh H.; Guerra, Flavia; Hamirwasia, Vibhushree; Misra, Archita; Satzinger, Katharina; Williamson, Laura E.; Lie, Mimi; Nilsson, Anna; Aberg, Emma; Weckend, Stephanie; Wuester, Henning; Ferroukhi, Rabia; Garcia, Celia; Khalid, Arslan; Renner, Michael; Taylor, Michael; Epp, Barbel; Seyboth, Kristin; Skeen, Jonathan; Kamiya, George; Munuera, Luis; Appavou, Fabiani; Brown, Adam; Kondev, Bozhil; Musolino, Evan; Brown, Adam; Mastny, Lisa; Arris, Lelani

    2018-06-01

    REN21's Renewables 2018 Global Status Report presents developments and trends through the end of 2017, as well as observed trends from early 2018 where available. Renewable power accounted for 70% of net additions to global power generating capacity in 2017, the largest increase in renewable power capacity in modern history, according to REN21's Renewables 2018 Global Status Report (GSR). But the heating, cooling and transport sectors - which together account for about four-fifths of global final energy demand - continue to lag far behind the power sector. The GSR, published today, is the most comprehensive annual overview of the state of renewable energy worldwide. New solar photovoltaic (PV) capacity reached record levels: Solar PV additions were up 29% relative to 2016, to 98 GW. More solar PV generating capacity was added to the electricity system than net capacity additions of coal, natural gas and nuclear power combined. Wind power also drove the uptake of renewables with 52 GW added globally. Investment in new renewable power capacity was more than twice that of net, new fossil fuel and nuclear power capacity combined, despite large, ongoing subsidies for fossil fuel generation. More than two-thirds of investments in power generation were in renewables in 2017, thanks to their increasing cost-competitiveness - and the share of renewables in the power sector is expected to only continue to rise. Investment in renewables was regionally concentrated: China, Europe and the United States accounted for nearly 75% of global investment in renewables in 2017. However, when measured per unit of gross domestic product (GDP), the Marshall Islands, Rwanda, the Solomon Islands, Guinea Bissau, and many other developing countries are investing as much as or more in renewables than developed and emerging economies. Both energy demand and energy-related CO 2 emissions rose substantially for the first time in four years. Energy-related CO 2 emissions rose by 1

  15. Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

  16. Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

    CERN Document Server

    HR Department

    2008-01-01

    Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

  17. 12MW Horns Rev experiment[Wind farm

    Energy Technology Data Exchange (ETDEWEB)

    Hasager, C.B.; Pena, A; Mikkelsen, T.; Courtney, M.; Antoniou, I.; Gryning, S.-E.; Hansen, P. [Risoe National Lab., DTU, Wind Energy Dept. (Denmark); Soerensen, P.B. [DONG Energy (Denmark)

    2007-10-15

    The 12MW project with the full title '12 MW wind turbines: the scientific basis for their operation at 70 to 270 m height offshore' has the goal to experimentally investigate the wind and turbulence characteristics between 70 and 270 m above sea level and thereby establish the scientific basis relevant for the next generation of huge 12 MW wind turbines operating offshore. The report describes the experimental campaign at the Horns Rev offshore wind farm at which observations from Doppler Laser LIDAR and SODAR were collected from 3 May to 24 October 2006. The challenges for mounting and operating the instruments on the transformer platform at Horns Rev were overcome by a close collaboration between DONG energy and Risoe National Laboratory DTU. The site is presented. In particular, three tall offshore meteorological masts, up to 70 m tall, provided a useful source of meteorological data for comparison to the remotely sensed wind and turbulence observations. The comparison showed high correlation. The LIDAR and SODAR wind and turbulence observations were collected far beyond the height of the masts (up to 160 m above sea level) and the extended profiles were compared to the logarithmic wind profile. Further studies on this part of the work are on-going. Technical detail on LIDAR and SODAR are provided as well as theoretical work on turbulence and atmospheric boundary layer flow. Selected results from the experimental campaign are reported. (au)

  18. Wind Farm Wake: The 2016 Horns Rev Photo Case

    Directory of Open Access Journals (Sweden)

    Charlotte Bay Hasager

    2017-03-01

    Full Text Available Offshore wind farm wakes were observed and photographed in foggy conditions at Horns Rev 2 on 25 January 2016 at 12:45 UTC. These new images show highly contrasting conditions regarding the wind speed, turbulence intensity, atmospheric stability, weather conditions and wind farm wake development as compared to the Horns Rev 1 photographs from 12 February 2008. The paper examines the atmospheric conditions from satellite images, radiosondes, lidar and wind turbine data and compares the observations to results from atmospheric meso-scale modelling and large eddy simulation. Key findings are that a humid and warm air mass was advected from the southwest over cold sea and the dew-point temperature was such that cold-water advection fog formed in a shallow layer. The flow was stably stratified and the freestream wind speed was 13 m/s at hub height, which means that most turbines produced at or near rated power. The wind direction was southwesterly and long, narrow wakes persisted several rotor diameters downwind of the wind turbines. Eventually mixing of warm air from aloft dispersed the fog in the far wake region of the wind farm.

  19. rev piyasaları ve vergilendirilmesi

    OpenAIRE

    İşler, İsmail; Utku, Mehmet

    2015-01-01

    rev piyasaları kavramı, vadeli işlem sözleşmeleri (forward, futures), opsiyon sözleşmeleri, swap sözleşmeleri ve aracı kuruluş varantları işlemlerinin tamamını içermektedir. Bu tür işlemler vadeli işlemlerdir. Vadeli işlemlerin ortak özelliği, ilerideki bir tarihte teslimatı yapılmak üzere herhangi bir malın veya finansal aracın, bugünden alım satımının yapılmasıdır. Bu çalışmada türev araçların tanımları ve vergilendirilmeleri örneklerle açıklanacaktır. The term derivatives market invol...

  20. 1998 Annual Status Report: Status and Trend of Submersed and Floating-leaved Aquatic Vegetation in Thirty-two Backwaters in Pools 4, 8, 13, and 26 and La Grange Pool of the Upper Mississippi River System

    National Research Council Canada - National Science Library

    Yin, Yao

    2000-01-01

    .... The status and trend of aquatic vegetation in 1998 varied among the thirty-two backwaters. In upper Pool 4 (above Lake Pepin), where aquatic vegetation has declined since 1991, the trend continued in 1998...

  1. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (82nd, New Orleans, Louisiana, August 3-8, 1999). Status of Women.

    Science.gov (United States)

    Association for Education in Journalism and Mass Communication.

    The Status of Women section of the Proceedings contains the following 8 papers: "Coverage of Mars Exploration: Media Messages about Women Scientists" (Karon R. Speckman and Lois A. Bichler); "The Case of President Clinton and the Feminists: Discourses of Feminism in the News" (Dustin Harp); "Liberal Feminist Theory and…

  2. Applications of the INFCIRC225/rev5 to the national physical protection regime

    International Nuclear Information System (INIS)

    Kim, Jae Gwang

    2011-01-01

    The IAEA's first effort for playing a key role in physical protection of nuclear material and facilities resulted in the publication of 'Recommendations for the physical protection of nuclear material' in 1972. These recommendations were revised by a group of experts in co-operation with the IAEA Secretariat and the revised version was published in 1975 in INFCIRC/225. The document was subsequently revised in 1977(rev.1), 1989(rev.2), in 1993(rev.3) and 1998(rev4). The Physical Protection regime in ROK has been established on the basis of INFCIRC225 rev4 since 2004 IAEA recently published The INFCIRC 225 rev5 through the 2 years expert consultations. The publication recommended 12 nuclear security fundamentals and requirements of physical protection of nuclear material and nuclear facility to the member states. This paper suggests the several applications to the national physical protection system from the 12 fundamentals and the requirements

  3. Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee at its meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

  4. Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

  5. REV7, a new gene concerned with UV mutagenesis in yeast

    International Nuclear Information System (INIS)

    Lawrence, C.W.; Das, G.; Christensen, R.B.

    1985-01-01

    Three allelic mutations of a new yeast gene, which we have named REV7, have been isolated by testing 313 methyl methane sulfonate sensitive mutants for UV-induced reversion of a lys2 allele. Rev7 mutants are markedly deficient with respect to UV-induced reversion of lys2, are slightly sensitive to UV and appear to be in the RAD6 epistasis group for UV survival. Rev7-1, which is probably an amber mutation, does not appear to affect sporulation in homozygous diploids. The REV7 gene is located about 12 cM distal to HIS5 on chromosome IX. (orig.)

  6. REV7, a new gene concerned with UV mutagenesis in yeast

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, C.W.; Das, G.; Christensen, R.B.

    1985-06-26

    Three allelic mutations of a new yeast gene, which we have named REV7, have been isolated by testing 313 methyl methane sulfonate sensitive mutants for UV-induced reversion of a lys2 allele. REV7 mutants are markedly deficient with respect to UV-induced reversion of lys2, are slightly sensitive to UV and appear to be in the RAD6 epistasis group for UV survival. Rev7-1, which is probably an amber mutation, does not appear to affect sporulation in homozygous diploids. The REV7 gene is located about 12 cM distal to HIS5 on chromosome IX.

  7. Status of national programmes on fast reactors 1997/98. 31. annual meeting of the International Working Group on Fast Reactors

    International Nuclear Information System (INIS)

    1998-01-01

    The objective of the meeting was to co-ordinate the exchange of information on the status of fast reactor development and operational experience, including experience with experimental types of reactor; to consider meeting arrangements for 1998 and 1999; and to review the IAEA co-ordinated research activities in the field of fast reactor, as well as co-ordination of the International Working Group on Fast Reactors activities with other organizations

  8. Annual Report to the Nation on the Status of Cancer, 1975-2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State.

    Science.gov (United States)

    Kohler, Betsy A; Sherman, Recinda L; Howlader, Nadia; Jemal, Ahmedin; Ryerson, A Blythe; Henry, Kevin A; Boscoe, Francis P; Cronin, Kathleen A; Lake, Andrew; Noone, Anne-Michelle; Henley, S Jane; Eheman, Christie R; Anderson, Robert N; Penberthy, Lynne

    2015-06-01

    The American Cancer Society (ACS), Centers for Disease Control and Prevention (CDC), National Cancer Institute (NCI), and North American Association of Central Cancer Registries (NAACCR) collaborate annually to produce updated, national cancer statistics. This Annual Report includes a focus on breast cancer incidence by subtype using new, national-level data. Population-based cancer trends and breast cancer incidence by molecular subtype were calculated. Breast cancer subtypes were classified using tumor biomarkers for hormone receptor (HR) and human growth factor-neu receptor (HER2) expression. Overall cancer incidence decreased for men by 1.8% annually from 2007 to 2011 [corrected]. Rates for women were stable from 1998 to 2011. Within these trends there was racial/ethnic variation, and some sites have increasing rates. Among children, incidence rates continued to increase by 0.8% per year over the past decade while, like adults, mortality declined. HR+/HER2- breast cancers, the subtype with the best prognosis, were the most common for all races/ethnicities with highest rates among non-Hispanic white women, local stage cases, and low poverty areas (92.7, 63.51, and 98.69 per 100000 non-Hispanic white women, respectively). HR+/HER2- breast cancer incidence rates were strongly, positively correlated with mammography use, particularly for non-Hispanic white women (Pearson 0.57, two-sided P < .001). Triple-negative breast cancers, the subtype with the worst prognosis, were highest among non-Hispanic black women (27.2 per 100000 non-Hispanic black women), which is reflected in high rates in southeastern states. Progress continues in reducing the burden of cancer in the United States. There are unique racial/ethnic-specific incidence patterns for breast cancer subtypes; likely because of both biologic and social risk factors, including variation in mammography use. Breast cancer subtype analysis confirms the capacity of cancer registries to adjust national collection

  9. Annual Status Report (FY2008) Composite Analysis of Low-Level Waste Disposal in the Central Plateau at the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, W. E. [Hanford Site (HNF), Richland, WA (United States)

    2009-12-18

    In accordance with the U.S. Department of Energy (DOE) requirements in DOE 0 435.1, Radioactive to be considered or purposes of Waste Management, and implemented by DOE/RL-2000-292, Maintenance Plan for the Composite Analysis of the Hanford Site, Southeast Washington, the DOE Richland Operations Office has prepared this annual report for fiscal year 2008 of PNNL-1 1800, Composite Analysis for the Low-Level Waste Disposal in the 200-Area Plateau of the Hanford Site, hereafter referred to as the Composite Analysis. The main emphasis of DOE/RL-2000-29 Is to identify additional data and information to enhance the Composite Analysis and the subsequent PNNL- 11800 Addendum, Addendum to Composite Analysis for Low-Level Waste Disposal in the 200 Area Plateau of the Hanford Site, hereafter referred to as the Addendum, and to address secondary issues identified during the review of the Composite Analysis.

  10. Epistatic participation of REV1 and REV3 in the formation of UV-induced frameshift mutations in cell cycle-arrested yeast cells

    Energy Technology Data Exchange (ETDEWEB)

    Heidenreich, Erich [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)]. E-mail: erich.heidenreich@meduniwien.ac.at; Eisler, Herfried [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria); Steinboeck, Ferdinand [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)

    2006-01-29

    Mutations arising in times of cell cycle arrest may provide a selective advantage for unicellular organisms adapting to environmental changes. For multicellular organisms, however, they may pose a serious threat, in that such mutations in somatic cells contribute to carcinogenesis and ageing. The budding yeast Saccharomyces cerevisiae presents a convenient model system for studying the incidence and the mechanisms of stationary-phase mutation in a eukaryotic organism. Having studied the emergence of frameshift mutants after several days of starvation-induced cell cycle arrest, we previously reported that all (potentially error-prone) translesion synthesis (TLS) enzymes identified in S. cerevisiae did not contribute to the basal level of spontaneous stationary-phase mutations. However, we observed that an increased frequency of stationary-phase frameshift mutations, brought about by a defective nucleotide excision repair (NER) pathway or by UV irradiation, was dependent on Rev3p, the catalytic subunit of the TLS polymerase zeta (Pol {zeta}). Employing the same two conditions, we now examined the effect of deletions of the genes coding for polymerase eta (Pol {eta}) (RAD30) and Rev1p (REV1). In a NER-deficient strain background, the increased incidence of stationary-phase mutations was only moderately influenced by a lack of Pol {eta} but completely reduced to wild type level by a knockout of the REV1 gene. UV-induced stationary-phase mutations were abundant in wild type and rad30{delta} strains, but substantially reduced in a rev1{delta} as well as a rev3{delta} strain. The similarity of the rev1{delta} and the rev3{delta} phenotype and an epistatic relationship evident from experiments with a double-deficient strain suggests a participation of Rev1p and Rev3p in the same mutagenic pathway. Based on these results, we propose that the response of cell cycle-arrested cells to an excess of exo- or endogenously induced DNA damage includes a novel replication

  11. Renewable energy annual 1995

    International Nuclear Information System (INIS)

    1995-12-01

    The Renewable Energy Annual 1995 is the first in an expected series of annual reports the Energy Information Administration (EIA) intends to publish to provide a comprehensive assessment of renewable energy. This report presents the following information on the history, status, and prospects of renewable energy data: estimates of renewable resources; characterizations of renewable energy technologies; descriptions of industry infrastructures for individual technologies; evaluations of current market status; and assessments of near-term prospects for market growth. An international section is included, as well as two feature articles that discuss issues of importance for renewable energy as a whole. The report also contains a number of technical appendices and a glossary. The renewable energy sources included are biomass (wood), municipal solid waste, biomass-derived liquid fuels, geothermal, wind, and solar and photovoltaic

  12. Renewable energy annual 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    The Renewable Energy Annual 1995 is the first in an expected series of annual reports the Energy Information Administration (EIA) intends to publish to provide a comprehensive assessment of renewable energy. This report presents the following information on the history, status, and prospects of renewable energy data: estimates of renewable resources; characterizations of renewable energy technologies; descriptions of industry infrastructures for individual technologies; evaluations of current market status; and assessments of near-term prospects for market growth. An international section is included, as well as two feature articles that discuss issues of importance for renewable energy as a whole. The report also contains a number of technical appendices and a glossary. The renewable energy sources included are biomass (wood), municipal solid waste, biomass-derived liquid fuels, geothermal, wind, and solar and photovoltaic.

  13. Waste Area Group 10, Operable Unit 10-08, Remedial Investigation/Feasibility Study Annual Status Report for Fiscal Year 2006

    Energy Technology Data Exchange (ETDEWEB)

    R. P. Wells

    2007-05-09

    This report provides a status of the progress made in Fiscal Year 2006 on tasks identified in the Waste Area Group 10, Operable Unit 10-08, Remedial Investigation/Feasibility Study Work Plan. Major accomplishments include: (1) groundwater sampling and review of the groundwater monitoring data, (2) installation of a Sitewide groundwater-level monitoring network, (3) update of the Groundwater Monitoring and Field Sampling Plan of Operable Unit 10-08, (4) re-evaluation of the risk at Site TSF-08, (5) progress on the Operable Unit 10-08 Sitewide Groundwater Model.

  14. SSC-K code users manual (rev.1)

    International Nuclear Information System (INIS)

    Kwon, Y. M.; Lee, Y. B.; Chang, W. P.; Hahn, D.

    2002-01-01

    The Supper System Code of KAERI (SSC-K) is a best-estimate system code for analyzing a variety of off-normal or accidents in the heat transport system of a pool type LMR design. It is being developed at Korea Atomic Energy Research Institution (KAERI) on the basis of SSC-L, originally developed at BNL to analyze loop-type LMR transients. SSC-K can handle both designs of loop and pool type LMRs. SSC-K contains detailed mechanistic models of transient thermal, hydraulic, neutronic, and mechanical phenomena to describe the response of the reactor core, coolant, fuel elements, and structures to accident conditions. This report provides a revised User's Manual (rev.1) of the SSC-K computer code, focusing on phenomenological model descriptions for new thermal, hydraulic, neutronic, and mechanical modules. A comprehensive description of the models for pool-type reactor is given in Chapters 2 and 3; the steady-state plant characterization, prior to the initiation of transient is described in Chapter 2 and their transient counterparts are discussed in Chapter 3. Discussions on the intermediate heat exchanger (IHX) and the electromagnetic (EM) pump are described in Chapter 4 and 5, respectively. A model of passive safety decay heat removal system (PSDRS) is discussed in Chapter 6, and models for various reactivity feedback effects are discussed in Chapter 7. In Chapter 8, constitutive laws and correlations required to execute the SSC-K are described. New models developed for SSC-K rev.1 are two dimensional hot pool model in Chapter 9, and long term cooling model in Chapter 10. Finally, a brief description of MINET code adopted to simulate BOP is presented in Chapter 11. Based on test runs for typical LMFBR accident analyses, it was found that the present version of SSC-K would be used for the safety analysis of KALIMER. However, the further validation of SSC-K is required for real applications. It is noted that the user's manual of SSC-K will be revised later with the

  15. Horns Rev offshore wind power farm. Environmental impact assessment on water quality

    International Nuclear Information System (INIS)

    Andersen, Per

    2000-05-01

    As part of an overall Environmental Impact Assessment (EIA) undertaken in connection with a planned 150 MW offshore wind farm at Horns Rev, an assessment was made of the effects the wind farm would have on the water quality in the area. This EIA study was drawn up in accordance with the guidelines laid down by the Danish Ministry of Environment and Energy in the publication 'Guidelines for the preparation of EIA studies for offshore wind farms'. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. Only local and minor changes are anticipated in connection with the currents, sediments and wave conditions during the production phase. These will occur in the immediate vicinity of the individual foundations. For these reasons, no changes are expected in the water quality. This also includes also the pelagic primary production and the occurrence of plankton in the area. Increased local copper contamination of phytoplankton and zooplankton may be expected during the production phase, as a result of the total annual discharge of 206 kg copper from the slip-rings in the wind turbines. The contamination will potentially result in a local reduction of the pelagic primary production and changes in the species composition of the plankton. The wind turbines will be sandblasted and painted once during their lifetime, as part of the routine maintenance. The sandblasting and painting will lead to a temporary spill of paint, paint waste and sand. The impacts on water quality and plankton production are unknown. It is recommended that factors such as the toxicity of the paint be investigated, and that spills and the impact of waste be reduced as much as possible. The water quality and the plankton in the wind farm area and along the cable line's passage to shore through the international protected area, will only be affected in a minor way

  16. TIARA annual report 1999

    Energy Technology Data Exchange (ETDEWEB)

    Saidoh, Masahiro; Toraishi, Akio; Itoh, Hisayoshi [eds.; Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment; and others

    2000-10-01

    This annual report describes research and development activities which have been performed with the JAERI TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities from April 1, 1999 to March 31, 2000. Summary reports of 106 papers and brief descriptions on the status of TIARA in the period are contained. A list of publications, the type of research collaborations and organization of TIARA are also given as appendices. (author)

  17. TIARA annual report 2000

    Energy Technology Data Exchange (ETDEWEB)

    Saidoh, Masahiro; Toraishi, Akio; Namba, Hideki [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment; and others

    2001-11-01

    This annual report describes research and development activities which have been performed with the JAERI TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities from April 1, 2000 to March 31, 2001. Summary reports of 103 papers and brief descriptions on the status of TIARA in the period are contained. A list of publications, the type of research collaborations and organization of TIARA are also given as appendices. (author)

  18. TIARA annual report 2003

    International Nuclear Information System (INIS)

    Ohara, Yoshiro; Arakawa, Kazuo; Tanaka, Shigeru; Naramoto, Hiroshi; Yoshida, Masaru; Itoh, Hisayosi; Yoshikawa, Masato; Tanaka, Atsushi; Kobayashi, Yasuhiko; Fukuda, Mitsuhiro; Otsubo, Michiaki; Tajima, Satoshi; Tanaka, Susumu

    2004-11-01

    This annual report describes research and development activities which have been performed with the JAERI TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities from April 1, 2003 to March 31, 2004. Summary reports of 115 papers and brief descriptions on the status of TIARA in the period are contained. A list of publications, the type of research collaborations and organization of TIARA are also given as appendices. (author)

  19. Annual Report 2005

    Energy Technology Data Exchange (ETDEWEB)

    Michalik, J; Smulek, W; Godlewska-Para, E [eds.

    2006-07-01

    The Annual Report of the Institute of Nuclear Chemistry and Technology (Warsaw, Poland) describes the activities of the Institute in 2005. The document consist of four parts: (1) Radiation chemistry and physics, radiation technologies; (2) Radiochemistry, stable isotopes, nuclear analytical methods, general chemistry; (3) Radiobiology; (4) Nuclear technologies and methods. In total - 73 detailed papers prepared by the Institute workers and collaborating scientists are presented. General information on the Institute status, personnel activity and the international cooperation is also listed.

  20. TIARA annual report 2002

    International Nuclear Information System (INIS)

    2003-11-01

    This annual report describes research and development activities which have been performed with the JAERI TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities from April 1, 2002 to March 31, 2003. Summary reports of 113 papers and brief descriptions on the status of TIARA in the period are contained. A list of publications, the type of research collaborations and organization of TIARA are also given as appendices. (author)

  1. TIARA annual report 1997

    International Nuclear Information System (INIS)

    Tanaka, Ryuichi; Saido, Masahiro; Nashiyama, Isamu

    1998-10-01

    This annual report describes research activities which have been performed with the JAERI TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities from April 1, 1997 to March 31, 1998. Summary reports of 90 papers and brief descriptions on the status of TIARA in the period are contained. A list of publications, the type of research collaborations and organization of TIARA are also given as appendices. (author)

  2. TIARA annual report 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    This annual report describes research activities which have been performed with the JAERI TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities from April 1, 1996 to March 31, 1997. Summary reports of 88 papers and 4 brief descriptions on the status of TIARA in the period are contained. A list of publications, the type of research collaborations and organization of TIARA are also given as appendices. (J.P.N.)

  3. Annual Report 2005

    International Nuclear Information System (INIS)

    Michalik, J.; Smulek, W.; Godlewska-Para, E.

    2006-01-01

    The Annual Report of the Institute of Nuclear Chemistry and Technology (Warsaw, Poland) describes the activities of the Institute in 2005. The document consist of four parts: (1) Radiation chemistry and physics, radiation technologies; (2) Radiochemistry, stable isotopes, nuclear analytical methods, general chemistry; (3) Radiobiology; (4) Nuclear technologies and methods. In total - 73 detailed papers prepared by the Institute workers and collaborating scientists are presented. General information on the Institute status, personnel activity and the international cooperation is also listed

  4. TIARA annual report 2001

    International Nuclear Information System (INIS)

    Saidoh, Masahiro; Ohara, Yoshihiro; Namba, Hideki

    2002-11-01

    This annual report describes research and development activities which have been performed with the JAERI TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities from April 1, 2001 to March 31, 2002. Summary reports of 109 papers and brief descriptions on the status of TIARA in the period are contained. A list of publications, the type of research collaborations and organization of TIARA are also given as appendices. (author)

  5. TIARA annual report 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-10-01

    This annual report describes research and development activities which have been performed with the JAERI TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities from April 1, 1998 to March 31, 1999. Summary reports of 95 papers and brief descriptions on the status of TIARA in the period are contained. A list of publications, the type of research collaborations and organization of TIARA are also given as appendices. (author)

  6. Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.

    Science.gov (United States)

    Han, Chang Woo; Jeong, Mi Suk; Jang, Se Bok

    2017-09-16

    Ras proteins are small GTPases that serve as master moderators of a large number of signaling pathways involved in various cellular processes. Activating mutations in Ras are found in about one-third of cancers. H-REV107, a K-Ras binding protein, plays an important role in determining K-Ras function. H-REV107 is a member of the HREV107 family of class II tumor suppressor genes and a growth inhibitory Ras target gene that suppresses cellular growth, differentiation, and apoptosis. Expression of H-REV107 was strongly reduced in about 50% of human carcinoma cell lines. However, the specific molecular mechanism by which H-REV107 inhibits Ras is still unknown. In the present study, we suggest that H-REV107 forms a strong complex with activating oncogenic mutation Q61H K-Ras from various biochemical binding assays and modeled structures. In addition, the interaction sites between K-Ras and H-REV107 were predicted based on homology modeling. Here, we found that some structure-based mutants of the K-Ras disrupted the complex formation with H-REV107. Finally, a novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. RevManHAL: towards automatic text generation in systematic reviews.

    Science.gov (United States)

    Torres Torres, Mercedes; Adams, Clive E

    2017-02-09

    Systematic reviews are a key part of healthcare evaluation. They involve important painstaking but repetitive work. A major producer of systematic reviews, the Cochrane Collaboration, employs Review Manager (RevMan) programme-a software which assists reviewers and produces XML-structured files. This paper describes an add-on programme (RevManHAL) which helps auto-generate the abstract, results and discussion sections of RevMan-generated reviews in multiple languages. The paper also describes future developments for RevManHAL. RevManHAL was created in Java using NetBeans by a programmer working full time for 2 months. The resulting open-source programme uses editable phrase banks to envelop text/numbers from within the prepared RevMan file in formatted readable text of a chosen language. In this way, considerable parts of the review's 'abstract', 'results' and 'discussion' sections are created and a phrase added to 'acknowledgements'. RevManHAL's output needs to be checked by reviewers, but already, from our experience within the Cochrane Schizophrenia Group (200 maintained reviews, 900 reviewers), RevManHAL has saved much time which is better employed thinking about the meaning of the data rather than restating them. Many more functions will become possible as review writing becomes increasingly automated.

  8. Wind Farm Wake: The Horns Rev Photo Case

    Directory of Open Access Journals (Sweden)

    Pierre-Elouan Réthoré

    2013-02-01

    Full Text Available The aim of the paper is to examine the nowadays well-known wind farm wake photographs taken on 12 February 2008 at the offshore Horns Rev 1 wind farm. The meteorological conditions are described from observations from several satellite sensors quantifying clouds, surface wind vectors and sea surface temperature as well as ground-based information at and near the wind farm, including Supervisory Control and Data Acquisition (SCADA data. The SCADA data reveal that the case of fog formation occurred 12 February 2008 on the 10:10 UTC. The fog formation is due to very special atmospheric conditions where a layer of cold humid air above a warmer sea surface re-condensates to fog in the wake of the turbines. The process is fed by warm humid air up-drafted from below in the counter-rotating swirl generated by the clock-wise rotating rotors. The condensation appears to take place primarily in the wake regions with relatively high axial velocities and high turbulent kinetic energy. The wind speed is near cut-in and most turbines produce very little power. The rotational pattern of spiraling bands produces the large-scale structure of the wake fog.

  9. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3

    International Nuclear Information System (INIS)

    Kula, Anna; Gharu, Lavina; Marcello, Alessandro

    2013-01-01

    Human immunodeficiency virus gene expression and replication are regulated at several levels. Incompletely spliced viral RNAs and full-length genomic RNA contain the RRE element and are bound by the viral trans-acting protein Rev to be transported out of the nucleus. Previously we found that the nuclear matrix protein MATR3 was a cofactor of Rev-mediated RNA export. Here we show that the pleiotropic protein PSF binds viral RNA and is associated with MATR3. PSF is involved in the maintenance of a pool of RNA available for Rev activity. However, while Rev and PSF bind the viral pre-mRNA at the site of viral transcription, MATR3 interacts at a subsequent step. We propose that PSF and MATR3 define a novel pathway for RRE-containing HIV-1 RNAs that is hijacked by the viral Rev protein.

  10. Status and Habitat Requirements of White Sturgeon Populations in the Columbia River Downstream from McNary Dam, 1988-1989 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Nigro, Anthony A. (Oregon Dept. of Fish and Wildlife, Portland, OR (USA))

    1989-09-01

    We report on our progress from April 1988 through March 1989 on determining the status and habitat requirements of white sturgeon populations in the Columbia River downstream from McNary Dam. Highlights of results of our work in the Dalles and Bonneville reservoirs are: using setlines, we caught 1,586 sturgeon in The Dalles Reservoir and 484 sturgeon in Bonneville Reservoir in 1988. Fork length of fish caught ranged from 34 cm to 274 cm. Of the fish caught we marked 1,248 in The Dalles Reservoir and 341 in Bonneville Reservoir. Of the fish marked in 1988, we recaptured 82 in The Dalles Reservoir and none in Bonneville Reservoir. We recaptured 89 fish marked in 1987 in The Dalles Reservoir. Anglers recaptured 35 fish marked in 1988 and 16 fish marked in 1987 in The Dalles Reservoir. Anglers recaptured 2 sturgeon marked in 1988 in Bonneville Reservoir. Individual papers were processed separately for the data base.

  11. Caffeine Abolishes the Ultraviolet-Induced REV3 Translesion Replication Pathway in Mouse Cells

    Directory of Open Access Journals (Sweden)

    Kouichi Yamada

    2011-11-01

    Full Text Available When a replicative DNA polymerase stalls upon encountering a photoproduct on the template strand, it is relieved by other low-processivity polymerase(s, which insert nucleotide(s opposite the lesion. Using an alkaline sucrose density gradient sedimentation technique, we previously classified this process termed UV-induced translesion replication (UV-TLS into two types. In human cancer cells or xeroderma pigmentosum variant (XP-V cells, UV-TLS was inhibited by caffeine or proteasome inhibitors. However, in normal human cells, the process was insensitive to these reagents. Reportedly, in yeast or mammalian cells, REV3 protein (a catalytic subunit of DNA polymerase ζ is predominantly involved in the former type of TLS. Here, we studied UV-TLS in fibroblasts derived from the Rev3-knockout mouse embryo (Rev3KO-MEF. In the wild-type MEF, UV-TLS was slow (similar to that of human cancer cells or XP-V cells, and was abolished by caffeine or MG-262. In 2 cell lines of Rev3KO-MEF (Rev3−/− p53−/−, UV-TLS was not observed. In p53KO-MEF, which is a strict control for Rev3KO-MEF, the UV-TLS response was similar to that of the wild-type. Introduction of the Rev3 expression plasmid into Rev3KO-MEF restored the UV-TLS response in selected stable transformants. In some transformants, viability to UV was the same as that in the wild-type, and the death rate was increased by caffeine. Our findings indicate that REV3 is predominantly involved in UV-TLS in mouse cells, and that the REV3 translesion pathway is suppressed by caffeine or proteasome inhibitors.

  12. Mining the Human Complexome Database Identifies RBM14 as an XPO1-Associated Protein Involved in HIV-1 Rev Function

    OpenAIRE

    Budhiraja, Sona; Liu, Hongbing; Couturier, Jacob; Malovannaya, Anna; Qin, Jun; Lewis, Dorothy E.; Rice, Andrew P.

    2015-01-01

    By recruiting the host protein XPO1 (CRM1), the HIV-1 Rev protein mediates the nuclear export of incompletely spliced viral transcripts. We mined data from the recently described human nuclear complexome to identify a host protein, RBM14, which associates with XPO1 and Rev and is involved in Rev function. Using a Rev-dependent p24 reporter plasmid, we found that RBM14 depletion decreased Rev activity and Rev-mediated enhancement of the cytoplasmic levels of unspliced viral transcripts. RBM14 ...

  13. ANNUAL INTERVIEWS (MAPS)

    CERN Multimedia

    Human Resources Division

    2002-01-01

    The calendar for the 2002/2003 annual interview programme is confirmed as normally from 15 November 2002 to 15 February 2002 as foreseen in Administrative Circular N° 26 (rev. 2). However, where it is preferred to be as close as possible to 12 months since the last interview, supervisors and staff concerned may agree to the interview taking place up to 15 March 2003. This may also be necessary due to the roles of different supervisors resulting from the particular situations of divisional re-restructurings and detachments this year. The report form template is as last year available on the HR Division Website. A banner on the internal homepage leads directly to the page with the form. In collaboration with AS Division, the MAPS form including the personal data for the first page can be generated via the Human Resources Toolkit (HRT) application. For this exercise each staff member can now generate his/her own MAPS form. Information about how to do this is available here. Human Resources Division Tel. ...

  14. Status of National Programmes on Fast Breeder Reactors. International Working Group on Fast Reactors, Twentieth Annual Meeting, Vienna, 24-27 March 1987

    International Nuclear Information System (INIS)

    1987-07-01

    The Agenda of the meeting was as follows: 1. Approval of the Agenda. 2. Approval of the minutes of the 19th meeting of the IWGFR. 3. Report of the Scientific Secretary regarding the WD activities of the Working Group. 4. Presentations and discussions on national programmes on fast breeder reactors. 5. Consideration of conferences on fast breeder reactors. a. ANS-ENS International Conference on Fast Breeder Systems Experience Gained and Path to Economical Power Generation, Richland, Washington, USA, 13-17 September 1987. b. International Conference on Liquid Metal Engineering and Technology, Avignon, France, 17-20 October 1988. c. Other meetings of interest to IWGFR members. 6. Consideration of major recommendations of some of the WD IWGFR Specialists' Meetings. 7. Consideration of arrangements for Specialists' Meetings in 1987. a. Specialists' Meeting on Fission and Corrosion Products Behaviour in Primary Circuits of LMFBRs, Karlsruhe, Fed. Rep. of Germany, May 1987. b. Specialists' Meeting on LMFBR Reactor Block Antiseismic Design and Verification, Bologna, Italy, October 1987. 8. Selection of topics for Specialists' Meetings to be held in 1988 and suggestions of the IWGFR on other Specialists' Meetings and their justifications. 9. Consideration of joint research activities: a. Coordinated Research Programme on a Comparative Assessment of Processing Techniques for Analysis of Sodium Boiling Noise Detection Data. b. Coordinated Research Programme on Intercomparison of LMFBR Core Mechanics Codes. c. New Topics of CRP. d. Other Activities. 10. Updating of ''LMFBR Plant Parameters''. 11. Informal discussion on ''Safety Criteria for Fast Reactors in IWGFR Countries''. 12. The date and place of the 21th Annual Meeting of the IWGFR

  15. Status results of an annual campaign of continuous measurement of air radioactivity in Novozybkov, Briansk region. Recent data of a Russian-French study

    International Nuclear Information System (INIS)

    Petrov, E.; Zaboudko, A.; Seldiakov, Y.; Fertman, D.; Rizin, A.; Chemtob, M.; Charuau, J.; Sabroux, J.C.; Grivaud, L.; Fazileabasse, J.

    1996-01-01

    At the request of the Association of Radiological Problems of Russia (ARPR), in charge of environmental measurements and clean up of contaminated territories by Chernobyl accident, an instrument measuring continuously the radioactivity of aerosols in the environment was installed and operated for demonstration during a complete annual cycle in NOVOZYBKOV, Briansk Region (RUSSIA), in order to determine locally residual atmospheric contamination. This measuring campaign was carried out using the so called RADAIR instrument. This campaign was organised in the framework of a Russian -French cooperation between IPPE (Institute of Physics and Power Engineering, OBNINSK), SEC-SNIIP (Scientific and Engineering Center 'SNIP', MOSCOW), IPSN (Institut de Protection et de Surete Nucleaire, Fontenay-aux-Roses) and MGP-Instruments (LAMANON). The first step of the operation consisted in a preliminary verification of the instrument calibration in the site using aerosols sources deposited on filters. This calibration carried out on specialized facilities of IPSN and SEC-SNIIP showed a satisfactory agreement between different results. The second step consisted in exploiting the instrument. Beside the demonstration that the instrument worked suitably during its continuous operation in variable climatic conditions, the results obtained showed: - that the indicated volume activities of α and β emitters were low and near the instrument minimum values (for a: 4.10 -3 Bq.m -3 and for β: 10 -1 Bq.m -3 ); - that the indicated volume activities of 222 Rn lie between 2 and 30 Bq.m -3 (the high values are obtained in favourable climatic conditions: no wind, no rain or snow, soil not covered by snow and not frosted, etc.); - that the indicated environmental dose rate values at the point of measurement were of the order of 0.15 μGy.h -1 (150 μGy.h -1 ). (author)

  16. Phosphorus status and microbial community of paddy soil with the growth of annual ryegrass (Lolium multiflorum Lam.) under different phosphorus fertilizer treatments*

    Science.gov (United States)

    Guo, Hai-chao; Wang, Guang-huo

    2009-01-01

    Annual ryegrass (Lolium multiflorum Lam.) was grown in paddy soil in pots under different phosphorus (P) fertilizer treatments to investigate changes of P fractions and microbial community of the soil. The treatments included Kunyang phosphate rock (KPR) applications at 50 mg P/kg (KPR50) and 250 mg P/kg (KPR250), mono-calcium phosphate (MCP) application at 50 mg P/kg (MCP50), and the control without P application. The results showed that KPR50, KPR250, and MCP50 applications significantly increased the dry weight of the ryegrass by 13%, 38%, and 55%, and increased P uptake by 19%, 135%, and 324%, respectively. Compared with MCP50, the relative effectiveness of KPR50 and KPR250 treatments in ryegrass production was about 23% and 68%, respectively. After one season of ryegrass growth, the KPR50, KPR250, and MCP50 applications increased soil-available P by 13.4%, 26.8%, and 55.2%, respectively. More than 80% of the applied KPR-P remained as HCl-P fraction in the soil. Phospholipid fatty acid (PLFA) analysis showed that the total and bacterial PLFAs were significantly higher in the soils with KPR250 and MCP50 treatments compared with KPR50 and control. The latter had no significant difference in the total or bacterial PLFAs. The KPR50, KPR250, and MCP50 treatments increased fungal PLFA by 69%, 103%, and 69%, respectively. Both the principal component analysis and the cluster analysis of the PLFA data suggest that P treatments altered the microbial community composition of the soils, and that P availability might be an important contributor to the changes in the microbial community structure during the ryegrass growth in the paddy soils. PMID:19817001

  17. Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells

    Energy Technology Data Exchange (ETDEWEB)

    Ramakrishnan, Sathiya N.; Lau, Patrick; Crowther, Lisa M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cleasby, Mark E. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Millard, Susan; Leong, Gary M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cooney, Gregory J. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Muscat, George E.O., E-mail: g.muscat@imb.uq.edu.au [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia)

    2009-10-30

    The nuclear hormone receptor, Rev-erb beta operates as a transcriptional silencer. We previously demonstrated that exogenous expression of Rev-erb{beta}{Delta}E in skeletal muscle cells increased Srebp-1c mRNA expression. We validated these in vitro observations by injection of an expression vector driving Rev-erb{beta}{Delta}E expression into mouse tibialis muscle that resulted in increased Srebp-1c mRNA expression. Paradoxically, Rev-erb{beta} siRNA expression in skeletal muscle cells repressed Srebp-1c expression, and indicated that Rev-erb{beta} expression was necessary for Srebp-1c expression. ChIP analysis demonstrated that Rev-erb{beta} was recruited to the Srebp-1c promoter. Moreover, Rev-erb{beta} trans-activated the Srebp-1c promoter, in contrast, Rev-erb{beta} efficiently repressed the Rev-erb{alpha} promoter, a previously characterized target gene. Finally, treatment with the Rev-erb agonist (hemin) (i) increased the trans-activation of the Srebp-1c promoter by Rev-erb{beta}; and (ii) increased Rev-erb{beta} and Srebp-1c mRNA expression. These data suggest that Rev-erb{beta} has the potential to activate gene expression, and is a positive regulator of Srebp-1c, a regulator of lipogenesis.

  18. Status and Habitat Requirements of White Sturgeon Populations in the Columbia River Downstream from McNary Dam, 1989-1990 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Nigro, Anthony A. (Oregon Department of Fish and Wildlife, Portland, OR)

    1990-09-01

    We report on our progress from April 1989 through March 1990 on determining the status and habitat requirements of white sturgeon populations in the Columbia River downstream from McNary Dam. The study is a cooperative effort by the Oregon Department of Fish and Wildlife (ODFW), Washington Department of Fisheries (WDF), US Fish and Wildlife Service (FWS) and National Marine Fisheries Service (NMFS). Study objectives addressed by each agency are to describe the life history and population dynamics of subadults and adults between Bonneville and McNary dams and evaluate the need and identify potential methods for protecting, mitigating and enhancing populations downstream from McNary Dam, to describe the white sturgeon recreational fishery between Bonneville and McNary dams, describe reproductive and early life history characteristics downstream from Bonneville Dam and describe life history and population dynamics of subadults and adults downstream from Bonneville Dam, to describe reproduction and early life history characteristics, define habitat requirements for spawning and rearing and quantify extent of habitat available between Bonneville and McNary dams, and to describe reproduction and early life history characteristics, define habitat requirements for spawning and rearing and quantify extent of habitat available downstream from Bonneville Dam. Our approach is to work concurrently downstream and upstream from Bonneville Dam. Upstream from Bonneville Dam we began work in the Dalles Reservoir in 1987 and expanded efforts to Bonneville Reservoir in 1988 and John Day Reservoir in 1989. Highlights from this work is also included. 47 refs., 33 figs., 66 tabs.

  19. Status and Habitat Requirements of White Sturgeon Populations in the Columbia River Downstream from McNary Dam, 1986-1987 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    McCabe, Jr., George T. (National Marine Fisheries Service, Environmental and Technical Services Division, Portland, OR); Beckman, Lance G. (US Fish and Wildlife Service, Portland, OR); Kreitman, Gayle (Washington Department of Fisheries, Olympia, WA)

    1987-06-01

    Measure 804(e)(8) of the Northwest Power Planning Council (NPPC) Fish and Wildlife Program states that Bonneville Power Administration (BPA) ''shall fund research to determine the impacts of development and operation of the hydroelectric power system on sturgeon in the Columbia River Basin...'' In June 1985, BPA sponsored a workshop to define and list in priority order research needs in the basin (Fickeisen 1985a). In December 1985, BPA submitted a research program implementation plan (Fickeisen 1985b) to the NPPC. The purpose of the plan is to provide guidance for conducting research necessary to address four objectives identified by regional fishery interests for protecting, mitigating and enhancing white sturgeon populations in the Columbia River basin. The plan's objectives are: (1) Assess the current status of Columbia River basin white sturgeon stocks. (2) Provide the basis to evaluate the need for protection, mitigation and enhancement of white sturgeon in the Columbia River system. (3) Provide information that can be used to evaluate potential methods of protection, mitigation and enhancement of existing stocks. (4) Provide tools to assess the effectiveness of protection, mitigation and enhancement efforts.

  20. Review report 2004. The Danish offshore wind farm demonstration project: Horns Rev and Nysted offshore wind farms. Environmental impact assessment and monitoring

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-10-15

    The present review report presents the two wind farms Horns Rev and Nysted with regard to environmental characteristics and the results of the environmental studies carried out in connection with the Environmental Impact Assessment (EIA) and the baseline and monitoring programmes at the two sites. The descriptions of the programmes are based on extracts from the individual annual reports. Detailed information on method, programmes and conclusions can be found in these reports (see Appendix 1). This review report is divided into two parts. The first part contains a description of the potential environmental impacts of offshore wind farms and the potentially affected part of the environment. The second part includes a description of Horns Rev and Nysted Offshore Wind Farm and the environmental studies carried out here until the end of 2003. Appendix I is a list of the literature published on the studies carried out at Horns Rev and Nysted Offshore Wind Farm. Appendix II is a list of some of the literature relevant to the demonstration projects but not directly related to the projects. The offshore wind farm situated in the Roedsand area is officially denoted Nysted Offshore Wind Farm, and in the present report the denotation 'Nysted' will be used as well when referring to Nysted Offshore Wind Farm. The denotation Roedsand will be used when referring to the actual area Roedsand. (au)

  1. Review report 2003. The Danish offshore wind farm demonstration project: Horns Rev and Nysted offshore wind farms. Environmental impact assessment and monitoring

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-09-15

    The present review report presents the two wind farms Homs Rev and Nysted, with regard to environmental characteristics and the results of the environmental studies carried out in connection with the Environmental Impact Assessment (EIA) and the baseline and monitoring programmes at the two sites. The descriptions of the programmes are based on extracts from the individual annual reports. Detailed information on methods, programmes and conclusions can be found in these reports. This review report is divided into two parts. The first part contains a description of the potential environmentally impacts of offshore wind farms and the potentially affected part of the environment. The second part includes a description of Horns Rev and Nysted Offshore Wind Farm and the environmental studies carried out here until the end of 2003. Appendix I is a list of the literature published on the studies carried out at Hors Rev and Nysted Offshore Wind Farm. Appendix II is a list of some of the literature relevant to the demonstration projects but not directly related to the projects. The offshore wind farm situated at the bdsand area is officially denoted Nysted Offshore Wind Farm, and in the present report the denotation 'Nysted' will be used as well when referring to Nysted Offshore Wind Farm. The denotation Roedsand will be used when referring to the actual area Roedsand. (au)

  2. Review report 2004. The Danish offshore wind farm demonstration project: Horns Rev and Nysted offshore wind farms. Environmental impact assessment and monitoring

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-10-15

    The present review report presents the two wind farms Horns Rev and Nysted with regard to environmental characteristics and the results of the environmental studies carried out in connection with the Environmental Impact Assessment (EIA) and the baseline and monitoring programmes at the two sites. The descriptions of the programmes are based on extracts from the individual annual reports. Detailed information on method, programmes and conclusions can be found in these reports (see Appendix 1). This review report is divided into two parts. The first part contains a description of the potential environmental impacts of offshore wind farms and the potentially affected part of the environment. The second part includes a description of Horns Rev and Nysted Offshore Wind Farm and the environmental studies carried out here until the end of 2003. Appendix I is a list of the literature published on the studies carried out at Horns Rev and Nysted Offshore Wind Farm. Appendix II is a list of some of the literature relevant to the demonstration projects but not directly related to the projects. The offshore wind farm situated in the Roedsand area is officially denoted Nysted Offshore Wind Farm, and in the present report the denotation 'Nysted' will be used as well when referring to Nysted Offshore Wind Farm. The denotation Roedsand will be used when referring to the actual area Roedsand. (au)

  3. TEN YEARS OF THE NORTHEASTERN NURSING NETWORK JOURNAL - REV RENE: A DREAM COME TRUE

    Directory of Open Access Journals (Sweden)

    Inacia Sátiro Xavier de Franca

    2011-01-01

    Full Text Available Objetivou-se analisar a memória histórica da Rev Rene ao longo de uma década de sua existência destacando a sua organização, a produção científica e as conquistas alcançadas no concernente a sua indexação nas bases de dados. Estudo fenomenológico cujos dados foram coletados por meio de um formulário, submetidos a associações livres e interpretados em consonância com “A poética do espaço”. Os núcleos foram: Universidade Federal do Ceará (UFC — A casa da Rev Rene; A Rev Rene — ninho — um espaço aberto aos pesquisadores da Saúde e áreas afins; Poética das gavetas do cofre e dos armários — o capital científico da Rev Rene à disposição dos leitores; A Rev Rene — concha — uma homologia poética; A Rev Rene é redonda — Metas e ações para a projeção no cenário nacional e internacional. A Rev Rene transpôs a dimensão do sonho e consolidou-se como um lócus de ciência.

  4. Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome

    Directory of Open Access Journals (Sweden)

    Ryan D. Welch

    2017-07-01

    Conclusions: Disrupting Rev-Erb activity in injured muscle accelerates regenerative muscle repair/differentiation through transcriptional de-repression of myogenic programs. Rev-Erb, therefore, may be a potent therapeutic target for a myriad of muscular disorders.

  5. Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Replication in HeLa Cells: A Comprehensive Study Using Alkaline Sucrose Density Gradient Sedimentation

    Directory of Open Access Journals (Sweden)

    Jun Takezawa

    2010-01-01

    Full Text Available When a replicative DNA polymerase stalls upon encountering a lesion on the template strand, it is relieved by other low-processivity polymerase(s, which insert nucleotide(s opposite the lesion, extend by a few nucleotides, and dissociate from the 3′-OH. The replicative polymerase then resumes DNA synthesis. This process, termed translesion replication (TLS or replicative bypass, may involve at least five different polymerases in mammals, although the participating polymerases and their roles have not been entirely characterized. Using siRNAs originally designed and an alkaline sucrose density gradient sedimentation technique, we verified the involvement of several polymerases in ultraviolet (UV light-induced TLS in HeLa cells. First, siRNAs to Rev3 or Rev7 largely abolished UV-TLS, suggesting that these 2 gene products, which comprise Polζ, play a main role in mutagenic TLS. Second, Rev1-targeted siRNA also abrogated UV-TLS, indicating that Rev1 is also indispensable to mutagenic TLS. Third, Polη-targeted siRNA also prevented TLS to a greater extent than our expectations. Forth, although siRNA to Polι had no detectable effect, that to Polκ delayed UV-TLS. To our knowledge, this is the first study reporting apparent evidence for the participation of Polκ in UV-TLS.

  6. Oak Ridge National Laboratory Waste Management Plan. Rev. 1

    Energy Technology Data Exchange (ETDEWEB)

    None

    1991-12-01

    The goal of the Oak Ridge National Laboratory (ORNL) Waste Management Program is the protection of workers, the public, and the environment. A vital aspect of this goal is to comply with all applicable state, federal, and DOE requirements. Waste management requirements for DOE radioactive wastes are detailed in DOE Order 5820.2A, and the ORNL Waste Management Program encompasses all elements of this order. The requirements of this DOE order and other appropriate DOE orders, along with applicable Tennessee Department of Environment and Conservation (TDEC) and US Environmental Protection Agency (EPA) rules and regulations, provide the principal source of regulatory guidance for waste management operations at ORNL. The objective of the Oak Ridge National Laboratory Waste Management Plan is to compile and to consolidate information annually on how the ORNL Waste Management is to compile and to consolidate information annually on how the ORNL Waste Management Program is conducted, which waste management facilities are being used to manage wastes, what forces are acting to change current waste management systems, what activities are planned for the forthcoming fiscal year (FY), and how all of the activities are documented.

  7. Sociological investigation of the reception of Horns Rev and Nysted offshore wind farms in the local communities[Denmark

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, S.

    2005-03-15

    This annual report presents the work related to the sociological part of the socio-economic project on the local communities' reception of the Horns Rev Offshore Wind Farm, west of Blaavands Huk in Jutland, and the Nysted Offshore Wind Farm, south of Lolland. The project is part of the monitoring programme in connection with the construction of the offshore wind farms. Unlike projects, which examine the impact of the wind farms on nature, the socio-economic project did not start until 2003. The socio-economic project examines the effects on the local communities. Among other things the environmental-economic part of the project examines the preferences of the population in relation to location of the wind farm and the willingness to pay for increasing the distance between the wind farms and the coast. The sociological survey is qualitative. The survey is divided into three phases, as the aim is to investigate the public community's attitude towards the erection of an offshore wind farm before and after the construction of the wind farm. This aim is based on the assumption that attitudes may change once the wind farm is erected and the population has experienced the visibility of the wind farm, etc. The division into phases is as follows: 1) Phase 1 treats the conditions as they were before the erection of Nysted Offshore Wind Farm. 2) Phase 2 is an investigation of the development in attitudes towards Horns Rev Offshore Wind Farm a year after erection. 3) Phase 3 comprises a follow-up investigation of the local area at Nysted Offshore Wind Farm. This annual report treats phases 1 and 2. Phase 1 was carried out in April-August 2003, and the interviews at Nysted were thus made during the erection of the first offshore wind turbines. Phase 2 was carried out in September-November 2003. The follow-up investigation of the conditions in the local area around Nysted offshore wind farm is to be carried out in August-December 2004. The results of the investigations

  8. Teede REV-2 otsustas börsile minna / Gea Velthut-Sokka

    Index Scriptorium Estoniae

    Velthut-Sokka, Gea, 1977-

    2004-01-01

    Eelmise aasta edukaima ehitusfirma Teede REV-2 ja tema suurinvestori Alta Kapital esindajad põhjendavad börsile mineku otsust. Tabelid ja diagrammid: Veerandi aktsiate omanikuvahetus börsilemineku peaprooviks

  9. REV ÜRÜNLERİN MUHASEBELEŞTİRİLMESİ

    OpenAIRE

    YURT, Eda

    2009-01-01

    Eda, Yurt, Türev Ürünlerin Muhasebelestirilmesi, Tezsiz Yüksek Lisans Dönem Projesi,Danısman: Doç. Dr. Kadir Gürdal, 58 s.BİTİRME PROJESİ ÖZETİProje finansal araçlar olarak türev ürünlerin muhasebelestirilmesine iliskinstandartların incelenmesini amaçlamaktadır. Öncelikle finansal risk tanımlanmıstır.Daha sonra türev piyasaların tarihi anlatılmıs ve islem gördükleri piyasalara göresınıflandırılmıstır. Bu temel açıklamalar sonrasında türev ürünler için UluslararasıMuhasebe Standartları incelen...

  10. The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes

    International Nuclear Information System (INIS)

    Fang Jianhua; Acheampong, Edward; Dave, Rajnish; Wang Fengxiang; Mukhtar, Muhammad; Pomerantz, Roger J.

    2005-01-01

    Productive infection by human immunodeficiency virus type I (HIV-1) in the central nervous system (CNS) involves mainly macrophages and microglial cells. A frequency of less than 10% of human astrocytes is estimated to be infectable with HIV-1. Nonetheless, this relatively low percentage of infected astrocytes, but associated with a large total number of astrocytic cells in the CNS, makes human astrocytes a critical part in the analyses of potential HIV-1 reservoirs in vivo. Investigations in astrocytic cell lines and primary human fetal astrocytes revealed that limited HIV-1 replication in these cells resulted from low-level viral entry, transcription, viral protein processing, and virion maturation. Of note, a low ratio of unspliced versus spliced HIV-1-specific RNA was also investigated, as Rev appeared to act aberrantly in astrocytes, via loss of nuclear and/or nucleolar localization and diminished Rev-mediated function. Host cellular machinery enabling Rev function has become critical for elucidation of diminished Rev activity, especially for those factors leading to RNA metabolism. We have recently identified a DEAD-box protein, DDX1, as a Rev cellular co-factor and now have explored its potential importance in astrocytes. Cells were infected with HIV-1 pseudotyped with envelope glycoproteins of amphotropic murine leukemia viruses (MLV). Semi-quantitative reverse transcriptase-polymerase chain reactions (RT-PCR) for unspliced, singly-spliced, and multiply-spliced RNA clearly showed a lower ratio of unspliced/singly-spliced over multiply-spliced HIV-1-specific RNA in human astrocytes as compared to Rev-permissive, non-glial control cells. As well, the cellular localization of Rev in astrocytes was cytoplasmically dominant as compared to that of Rev-permissive, non-glial controls. This endogenous level of DDX1 expression in astrocytes was demonstrated directly to lead to a shift of Rev sub-cellular distribution dominance from nuclear and/or nucleolar to

  11. Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation

    Science.gov (United States)

    Amador, Ariadna; Huitron-Resendiz, Salvador; Roberts, Amanda J.; Kamenecka, Theodore M.; Solt, Laura A.; Burris, Thomas P.

    2016-01-01

    The circadian clock maintains appropriate timing for a wide range of behaviors and physiological processes. Circadian behaviors such as sleep and wakefulness are intrinsically dependent on the precise oscillation of the endogenous molecular machinery that regulates the circadian clock. The identical core clock machinery regulates myriad endocrine and metabolic functions providing a link between sleep and metabolic health. The REV-ERBs (REV-ERBα and REV-ERBβ) are nuclear receptors that are key regulators of the molecular clock and have been successfully targeted using small molecule ligands. Recent studies in mice suggest that REV-ERB-specific synthetic agonists modulate metabolic activity as well as alter sleep architecture, inducing wakefulness during the light period. Therefore, these small molecules represent unique tools to extensively study REV-ERB regulation of sleep and wakefulness. In these studies, our aim was to further investigate the therapeutic potential of targeting the REV-ERBs for regulation of sleep by characterizing efficacy, and optimal dosing time of the REV-ERB agonist SR9009 using electroencephalographic (EEG) recordings. Applying different experimental paradigms in mice, our studies establish that SR9009 does not lose efficacy when administered more than once a day, nor does tolerance develop when administered once a day over a three-day dosing regimen. Moreover, through use of a time response paradigm, we determined that although there is an optimal time for administration of SR9009 in terms of maximal efficacy, there is a 12-hour window in which SR9009 elicited a response. Our studies indicate that the REV-ERBs are potential therapeutic targets for treating sleep problems as those encountered as a consequence of shift work or jet lag. PMID:27603791

  12. 76 FR 64071 - Annual Meeting

    Science.gov (United States)

    2011-10-17

    ... APPALACHIAN STATES LOW-LEVEL RADIOACTIVE WASTE COMMISSION Annual Meeting Time and Date: 10 a.m.-12..., PA 17101. Status: The meeting will be open to the public. Matters to be Considered: Portions Open to the Public: The primary purpose of this meeting is to (1) Review the independent auditors' report of...

  13. 75 FR 65297 - Annual Meeting

    Science.gov (United States)

    2010-10-22

    ... APPALACHIAN STATES LOW-LEVEL RADIOACTIVE WASTE COMMISSION Annual Meeting Time And Date: 10 a.m.-12..., PA 17101. Status: The meeting will be open to the public. Matters To Be Considered Portions Open to the Public: The primary purpose of this meeting is to (1) Review the independent auditors' report of...

  14. 78 FR 64472 - Annual Meeting

    Science.gov (United States)

    2013-10-29

    ... APPALACHIAN STATES LOW-LEVEL RADIOACTIVE WASTE COMMISSION Annual Meeting Time and Date: 10 a.m.-12... 17101. Status: The meeting will be open to the public. Matters To Be Considered: Portions Open To The Public: The primary purpose of this meeting is to (1) Review the independent auditors' report of...

  15. 77 FR 61737 - Annual Meeting

    Science.gov (United States)

    2012-10-11

    ... APPALACHIAN STATES LOW-LEVEL RADIOACTIVE WASTE COMMISSION Annual Meeting Time and Date: 10 a.m.-12... 17101. Status: The meeting will be open to the public. Matters To Be Considered Portions Open to the Public: The primary purpose of this meeting is to (1) Review the independent auditors' report of...

  16. Annual report 1991-1992

    International Nuclear Information System (INIS)

    1992-01-01

    The Annual Report 1991-92 contains an update on the NRPB's role in international and national standards, the technical services provided by the NRPB, their work on environmental, biomedical and physical sciences, the status of NRPB publications giving advice, the NRPB's finances, its senior directing staff and finally NRPB members. (UK)

  17. Offshore wind farms in the local environment - an examination at Horns Rev Offshore Wind Farm. Background report; Havvindmoeller i lokalomraadet - en undersoegelse ved Horns Rev Havmoellepark. Baggrundsrapport

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, Susanne

    2005-07-01

    Horns Rev Offshore Wind Farm was built in 2002. A presentation is made of a sociological, qualitative survey on the local community's reception of the offshore wind farm. The survey aims at identifying attitudes towards the farm before and after the construction, with a view to identifying possible changes in attitudes, and explain the reasons for these (ml)

  18. Annual Report 2006

    Energy Technology Data Exchange (ETDEWEB)

    Michalik, J; Smulek, W; Godlewska-Para, E [eds.

    2007-07-01

    The Annual Report of the Institute of Nuclear Chemistry and Technology (Warsaw, Poland) describes achievements of the Institute in 2006 obtained in seven fields: (1) radiation chemistry and technology, (2) radiochemistry and coordination chemistry, (3) radiobiology, (4) application of nuclear methods in material and process engineering, (5) design of instruments based on nuclear techniques, (6) trace analysis and radioanalytical techniques, (7) environmental research. In total - 83 detailed papers prepared by the Institute workers and collaborating scientists are presented. General information on the Institute status, personnel activity, international cooperation and publications are presented.

  19. Renewable energy annual 1996

    International Nuclear Information System (INIS)

    1997-03-01

    This report presents summary data on renewable energy consumption, the status of each of the primary renewable technologies, a profile of each of the associated industries, an analysis of topical issues related to renewable energy, and information on renewable energy projects worldwide. It is the second in a series of annual reports on renewable energy. The renewable energy resources included in the report are biomass (wood and ethanol); municipal solid waste, including waste-to-energy and landfill gas; geothermal; wind; and solar energy, including solar thermal and photovoltaic. The report also includes various appendices and a glossary

  20. Annual Report 2006

    International Nuclear Information System (INIS)

    Michalik, J.; Smulek, W.; Godlewska-Para, E.

    2007-01-01

    The Annual Report of the Institute of Nuclear Chemistry and Technology (Warsaw, Poland) describes achievements of the Institute in 2006 obtained in seven fields: (1) radiation chemistry and technology, (2) radiochemistry and coordination chemistry, (3) radiobiology, (4) application of nuclear methods in material and process engineering, (5) design of instruments based on nuclear techniques, (6) trace analysis and radioanalytical techniques, (7) environmental research. In total - 83 detailed papers prepared by the Institute workers and collaborating scientists are presented. General information on the Institute status, personnel activity, international cooperation and publications are presented

  1. Nuclear Medicine Annual, 1989

    International Nuclear Information System (INIS)

    Freeman, L.M.; Weissmann, H.S.

    1989-01-01

    Among the highlights of Nuclear Medicine Annual, 1989 are a status report on the thyroid scan in clinical practice, a review of functional and structural brain imaging in dementia, an update on radionuclide renal imaging in children, and an article outlining a quality assurance program for SPECT instrumentation. Also included are discussions on current concepts in osseous sports and stress injury scintigraphy and on correlative magnetic resonance and radionuclide imaging of bone. Other contributors assess the role of nuclear medicine in clinical decision making and examine medicolegal and regulatory aspects of nuclear medicine

  2. Annual Report 2008

    International Nuclear Information System (INIS)

    Michalik, J.; Smulek, W.; Godlewska-Para, E.

    2009-01-01

    The Annual Report of the Institute of Nuclear Chemistry and Technology (Warsaw, Poland) describes achievements of the Institute in 2008 obtained in six fields: (1) radiation chemistry and physics, radiation technologies, (2) radiochemistry, stable isotopes, nuclear analytical methods, general chemistry, (3) radiobiology, (4) nuclear technologies and methods: process engineering, (5) nuclear technologies and methods: material engineering, structural studies, diagnostics, (6) nucleonic control systems and accelerators. In total - 76 detailed papers prepared by the Institute workers and collaborating scientists are presented. General information on the Institute status, personnel activity, international cooperation and publications are also given

  3. Annual Report 2007

    International Nuclear Information System (INIS)

    Michalik, J.; Smulek, W.; Godlewska-Para, E.

    2008-01-01

    The Annual Report of the Institute of Nuclear Chemistry and Technology (Warsaw, Poland) describes achievements of the Institute in 2007 obtained in seven fields: (1) radiation chemistry and physics, radiation technologies; (2) radiochemistry, stable isotopes, nuclear analytical methods, general chemistry; (3) radiobiology; (4) nuclear technologies and methods: process engineering; (5) nuclear technologies and methods: material engineering, structural studies, diagnostics; (6) nuclear technologies and methods: nucleonic control systems and accelerators. In total - 76 detailed papers prepared by the Institute workers and collaborating scientists are presented. General information on the Institute status, personnel activity, international cooperation and publications are also given

  4. Renewable energy annual 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    This report presents summary data on renewable energy consumption, the status of each of the primary renewable technologies, a profile of each of the associated industries, an analysis of topical issues related to renewable energy, and information on renewable energy projects worldwide. It is the second in a series of annual reports on renewable energy. The renewable energy resources included in the report are biomass (wood and ethanol); municipal solid waste, including waste-to-energy and landfill gas; geothermal; wind; and solar energy, including solar thermal and photovoltaic. The report also includes various appendices and a glossary.

  5. Uranium Industry. Annual 1984

    International Nuclear Information System (INIS)

    Lawrence, M.S.S.

    1985-01-01

    This report provides a statistical description of activities of the US uranium industry during 1984 and includes a statistical profile of the status of the industry at the end of 1984. It is based on the results of an Energy Information Administration (EIA) survey entitled ''Uranium Industry Annual Survey'' (Form EIA-858). The principal findings of the survey are summarized under two headings - Uranium Raw Materials Activities and Uranium Marketing Activities. The first heading covers exploration and development, uranium resources, mine and mill production, and employment. The second heading covers uranium deliveries and delivery commitments, uranium prices, foreign trade in uranium, inventories, and other marketing activities. 32 figs., 48 tabs

  6. Annual Report 2007

    Energy Technology Data Exchange (ETDEWEB)

    Michalik, J; Smulek, W; Godlewska-Para, E [eds.

    2008-07-01

    The Annual Report of the Institute of Nuclear Chemistry and Technology (Warsaw, Poland) describes achievements of the Institute in 2007 obtained in seven fields: (1) radiation chemistry and physics, radiation technologies; (2) radiochemistry, stable isotopes, nuclear analytical methods, general chemistry; (3) radiobiology; (4) nuclear technologies and methods: process engineering; (5) nuclear technologies and methods: material engineering, structural studies, diagnostics; (6) nuclear technologies and methods: nucleonic control systems and accelerators. In total - 76 detailed papers prepared by the Institute workers and collaborating scientists are presented. General information on the Institute status, personnel activity, international cooperation and publications are also given.

  7. Nullbasic, a potent anti-HIV tat mutant, induces CRM1-dependent disruption of HIV rev trafficking.

    Directory of Open Access Journals (Sweden)

    Min-Hsuan Lin

    Full Text Available Nullbasic, a mutant of the HIV-1 Tat protein, has anti-HIV-1 activity through mechanisms that include inhibition of Rev function and redistribution of the HIV-1 Rev protein from the nucleolus to the nucleoplasm and cytoplasm. Here we investigate the mechanism of this effect for the first time, establishing that redistribution of Rev by Nullbasic is not due to direct interaction between the two proteins. Rather, Nullbasic affects subcellular localization of cellular proteins that regulate Rev trafficking. In particular, Nullbasic induced redistribution of exportin 1 (CRM1, nucleophosmin (B23 and nucleolin (C23 from the nucleolus to the nucleus when Rev was coexpressed, but never in its absence. Inhibition of the Rev:CRM1 interaction by leptomycin B or a non-interacting RevM10 mutant completely blocked redistribution of Rev by Nullbasic. Finally, Nullbasic did not inhibit importin β- or transportin 1-mediated nuclear import, suggesting that cytoplasmic accumulation of Rev was due to increased export by CRM1. Overall, our data support the conclusion that CRM1-dependent subcellular redistribution of Rev from the nucleolus by Nullbasic is not through general perturbation of either nuclear import or export. Rather, Nullbasic appears to interact with and disrupt specific components of a Rev trafficking complex required for its nucleocytoplasmic shuttling and, in particular, its nucleolar accumulation.

  8. Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function

    Directory of Open Access Journals (Sweden)

    St-Laurent Georges

    2006-11-01

    Full Text Available Abstract Background The HIV Rev protein is known to facilitate export of incompletely spliced and unspliced viral transcripts to the cytoplasm, a necessary step in virus life cycle. The Rev-mediated nucleo-cytoplasmic transport of nascent viral transcripts, dependents on interaction of Rev with the RRE RNA structural element present in the target RNAs. The C-terminal variant of dsRNA-binding nuclear protein 90 (NF90ctv has been shown to markedly attenuate viral replication in stably transduced HIV-1 target cell line. Here we examined a mechanism of interference of viral life cycle involving Rev-NF90ctv interaction. Results Since Rev:RRE complex formations depend on protein:RNA and protein:protein interactions, we investigated whether the expression of NF90ctv might interfere with Rev-mediated export of RRE-containing transcripts. When HeLa cells expressed both NF90ctv and Rev protein, we observed that NF90ctv inhibited the Rev-mediated RNA transport. In particular, three regions of NF90ctv protein are involved in blocking Rev function. Moreover, interaction of NF90ctv with the RRE RNA resulted in the expression of a reporter protein coding sequences linked to the RRE structure. Moreover, Rev influenced the subcellular localization of NF90ctv, and this process is leptomycin B sensitive. Conclusion The dsRNA binding protein, NF90ctv competes with HIV Rev function at two levels, by competitive protein:protein interaction involving Rev binding to specific domains of NF90ctv, as well as by its binding to the RRE-RNA structure. Our results are consistent with a model of Rev-mediated HIV-1 RNA export that envisions Rev-multimerization, a process interrupted by NF90ctv.

  9. Contrast media. Safety issues and ESUR guidelines. 2. rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Thomsen, Henrik S. [Copenhagen University Hospital, Herlev (Denmark). Dept. of Diagnostic Radiology; Copenhagen Univ., Herlev (Denmark). Dept. of Diagnostic Sciences; Webb, Judith A.W. (eds.) [St. Bartholomew' s Hospital London Univ. (United Kingdom). Dept. of Radiology

    2009-07-01

    In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned members, reviewed the literature, proposed guidelines and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006. This second edition not only updates the previous edition, but also contains some completely new chapters, for example on gadolinium-based contrast agents, meta-analyses in contrast media research and various regulatory issues. Comprehensive consideration is given to the many different safety issues relating to iodinated, MR, ultrasound and barium contrast media. The text includes chapters on both acute and delayed non-renal adverse reactions and on renal adverse reactions. All those questions frequently raised in radiological practice are addressed, and the well-known ESUR guidelines on contrast media are included. This book, presented in a handy, easy to use format, provides an invaluable, unique and unparalleled source of information on the safety issues relating to contrast media. (orig.)

  10. Electric power distribution. 5th Rev. Ed. Elektrische Energieverteilung

    Energy Technology Data Exchange (ETDEWEB)

    Flosdorff, R; Hilgarth, G

    1986-01-01

    The first chapter on electric power supply networks discusses transmitting media, their characteristic values, and the dimensioning of electric lines and networks; cables are given particular attention. High-voltage d.c. transmission and reactive power compensation are discussed. The next chapter describes the calculation of short-circuits and earth leakages for various neutral circuits on the basis of symmetric components. The newly introduced mesh current method for complex calculation of electric networks makes use of the potential of pocket computers. Chapter 3 discusses protective devices, i.e. earth systems and electronic protection. The next two chapters describe switch gear and power plants, including recent technical changes. The final chapter, which discusses the electric power industry, has been rewritten and extended. Methods of calculation, e.g. annual cost and cash value, are applied to transmitting media and plants. There is an extensive appendix with characteristic values of cables and overhead lines, graphical symbols, distinguishing signs of wiring diagrams, a bibliography of books, DIN standards, VDE specifications, and formulas.

  11. Contrast media. Safety issues and ESUR guidelines. 2. rev. ed.

    International Nuclear Information System (INIS)

    Thomsen, Henrik S.; Copenhagen Univ., Herlev; Webb, Judith A.W.

    2009-01-01

    In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned members, reviewed the literature, proposed guidelines and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006. This second edition not only updates the previous edition, but also contains some completely new chapters, for example on gadolinium-based contrast agents, meta-analyses in contrast media research and various regulatory issues. Comprehensive consideration is given to the many different safety issues relating to iodinated, MR, ultrasound and barium contrast media. The text includes chapters on both acute and delayed non-renal adverse reactions and on renal adverse reactions. All those questions frequently raised in radiological practice are addressed, and the well-known ESUR guidelines on contrast media are included. This book, presented in a handy, easy to use format, provides an invaluable, unique and unparalleled source of information on the safety issues relating to contrast media. (orig.)

  12. REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.

    Directory of Open Access Journals (Sweden)

    Gwendal Le Martelot

    2009-09-01

    Full Text Available In mammals, many aspects of behavior and physiology, and in particular cellular metabolism, are coordinated by the circadian timing system. Molecular clocks are thought to rely on negative feedback loops in clock gene expression that engender oscillations in the accumulation of transcriptional regulatory proteins, such as the orphan receptor REV-ERBalpha. Circadian transcription factors then drive daily rhythms in the expression of clock-controlled output genes, for example genes encoding enzymes and regulators of cellular metabolism. To gain insight into clock output functions of REV-ERBalpha, we carried out genome-wide transcriptome profiling experiments with liver RNA from wild-type mice, Rev-erbalpha knock-out mice, or REV-ERBalpha overexpressing mice. On the basis of these genetic loss- and gain-of-function experiments, we concluded that REV-ERBalpha participates in the circadian modulation of sterol regulatory element-binding protein (SREBP activity, and thereby in the daily expression of SREBP target genes involved in cholesterol and lipid metabolism. This control is exerted via the cyclic transcription of Insig2, encoding a trans-membrane protein that sequesters SREBP proteins to the endoplasmic reticulum membranes and thereby interferes with the proteolytic activation of SREBPs in Golgi membranes. REV-ERBalpha also participates in the cyclic expression of cholesterol-7alpha-hydroxylase (CYP7A1, the rate-limiting enzyme in converting cholesterol to bile acids. Our findings suggest that this control acts via the stimulation of LXR nuclear receptors by cyclically produced oxysterols. In conclusion, our study suggests that rhythmic cholesterol and bile acid metabolism is not just driven by alternating feeding-fasting cycles, but also by REV-ERBalpha, a component of the circadian clockwork circuitry.

  13. 1980 Annual status report: super-SARA

    International Nuclear Information System (INIS)

    1981-01-01

    The essential tasks of the JRC for the SUPERSARA project during 1980 were therefore twofold: 1. Actuation of an international Task Force with which to: a. discuss in depth the test objectives and the relationships between the SSTP and the world mosaic of activities in the field of LWR fuel behaviour; b. establish a consensus test matrix; c. identify and discuss the major technological problems affecting the feasibility of attaining the consensus test objectives, especially for the boil-down SFD tests. A Task Force with these objectives was necessary in order to provide the elements for a Council decision on phase II. 2. Conservation of the rythm of the main contractor (UKAEA-Harwell) and subcontractors for the timely fabrication of loop components and the timely design of those new aspects of the plant necessary for the boil-down SFD tests

  14. Annual status report 31 December 1975

    International Nuclear Information System (INIS)

    1976-06-01

    The desired current distribution in the high-β experiment SPICA can be maintained on a 100 μs time-scale. In the turbulent heating experiment, a plasma with parameters not unlike those in current tokamak experiments was produced in a much shorter time-scale. Gas-blanket research was carried out both in the Institute's Ringboog facility and in Alcator at MIT. A comparison of the achievements of these experiments underlines the advantage of the Alcator scheme. Work with Ringboog now aims at understanding the mechanisms responsible for the energy loss (both radiation and instability being significant) and at controlling the current-density profile by means of turbulent heating of a skin. The emphasis of the work in the theoretical group has been in the fields of magnetohydrodynamics and transport theory. In particular, the problem of the β-limits for stable equilibria in tokamak and screw-pinch configurations was investigated. It was confirmed that, from this point of view, a screw pinch has more favourable properties than a tokamak. Studies into the effect of non-circular cross-sections were started. As regards transport phenomena due to binary collisions, work was initiated to complete the picture for different possible regimes. The studies on transport due to impurity-driven dissipative drift modes were continued. The investigation of the wave dynamics in an homogeneous plasma was extended to include quasi-linear effects. Research was also started to evaluate the potentialities of using advanced fuels in fusion reactors

  15. Annual status report 31 December 1976

    International Nuclear Information System (INIS)

    1977-07-01

    The 1976 activities of the institute as related to fusion research are described in three sections. In the first section, the experimental division, work is reported on the long-term behavior of screw pinch plasmas in SPICA and the short-term behavior of the non-circular plasma is SP IV b. The second section, the theoretical division, describes the work done on magnetohydrodynamics of toroidal systems, on wave dynamics in inhomogeneous plasmas, transport phenomena in plasmas and on advanced fusion fuels. The third section, technology and engineering, summarizes the activities done in support of the experimental studies and the contribution of FOM members to the Joint European Torus project

  16. 1982 annual status report: reactor safety

    International Nuclear Information System (INIS)

    1982-01-01

    This report presents the projects of the Reactor Safety Program at the JRC: 1) Reliability and risk evolution; 2) LWR loss of coolant accident studies; 3) Primary system integrity; 4) LMFBR core accident initiation and transition phase; and, 5) LMFBR accident post disassembly phase

  17. Annual status report, 3l December 1974

    International Nuclear Information System (INIS)

    1975-08-01

    With the completion of the construction of the turbulent heating experiment, TORTURE, the Institute now has three toroidal experiments in operation. SPICA, a small aspect ratio toroidal screw pinch, was built to investigate the effect of force-free currents in the outer regions of the pinch on the equilibrium and the stability of the plasma. In RINGBOOG, a study is made of the influence of a cold neutral gas envelope on a Tokamak-like discharge. TORTURE was designed to expand on the heating results obtained in a linear experiment. The first results from SPICA are encouraging mainly because the induced toroidal current persists much longer than in smaller screw pinches. In the turbulent heating experiments, spectroscopic linebroadening measurements yielded important information on fluctuation spectra. Experiments in RINGBOOG have been carried out at densities appreciably higher than those in most current Tokamaks but at correspondingly lower temperatures. The equilibrium and the energy balance have been studied in low-power discharges and are fairly well understood. Operation in a high-power mode has yielded evidence of slightly turbulent heating and was accompanied by a favorable effect on the current profile, i.e., the current profile broadened. This experiment will provide further insight in how density, temperature, and current profiles are affected by a gas blanket. After a long period of technical difficulties, the Alcator experiment produced important results, notably on the effects of non-thermal electron distribution functions and on the possibility to operate Tokamaks in unusual regimes, both with respect to plasma purity and high density. The study of the spectrum of ideal MHD was continued and extended to a toroidal geometry. An investigation was initiated on the equilibrium and stability of high-β Tokamaks. MHD-waves in an inhomogeneous plasma are damped. The role of impurities in a discharge is studied with two different approaches. Impurity driven modes will lead to a limitation of the density of the impurities in the centre of the discharge. A numerical study of a reactor model shows that the concentration of impurities in the centre is affected by the thermal force arising from collisions between different types of ions

  18. 1980 Annual status report: training and education

    International Nuclear Information System (INIS)

    1981-01-01

    Although not as high as in 1977 or 1979, the external response to the courses, which is a good measure of the usefulness and the efficiency of this programme, has maintained a satisfactory level in 1980. Porgress in the diversification of the subjects, as a result of the development of new areas in JRC research, and of the objectives, with the implementation of a programme for developing countries, is encouraging

  19. 1980 Annual status report: thermonuclear fusion technology

    International Nuclear Information System (INIS)

    1981-01-01

    According to the decisions taken by the Council of Ministers on the JRC multiannual programme (1980-83), the 1980 activity has been oriented toward four projects which cover a broad range of fields, namely: - the Project 1: 'Reactor Studies'. The main effort was oriented toward the NET/INTOR studies. JRC Ispra is acting as reference nucleus for NET preliminary design. For the moment being this work was made in support to the European participation to INTOR. In 1980 the conceptual design of a demonstration power reactor (FINTOR-D) was also achieved. - The Project 2: 'Blanket Technology' has the aim to investigate structural materials behaviour in fusion conditions. Items like tritium outgassing and permeation from structurals an materials compatibility were investigated. - The Projet 3: 'Material sorting and development'. Its aim is to assess mechanical properties and radiation damage of standard and advanced materials suited for reactor structures. - The Projet 4: 'Cyclotron construction and operation' has the task to install and exploit a cyclotron to simulate demages to materials in a fusion ambient

  20. 1981 Annual status report. Nuclear measurements

    International Nuclear Information System (INIS)

    1982-01-01

    The Nuclear Measurements programme is divided into two main projects, Nuclear Data on the one hand and Nuclear Reference Materials and Techniques on the other. In the former the JRC actions form part of world-wide sets of actions to establish reliable, and in many cases very precise, figures for important nuclear parameters - e.g. neutron interaction cross-sections, radio-nuclide half lives. In this work the Central Bureau for Nuclear Measurements (CBNM) pays particular attention to the specific needs of the Community and to complement similar actions undertaken in the laboratories belonging to the Member States. Concerning Nuclear Reference Materials and Techniques the actions are to provide materials to which analytical and other measurements carried out in the nuclear industry or by the nuclear community can be referred. The basic aim of the Nuclear measurement programme is therefore to develop nuclear metrology with special orientation towards satisfying the demands for basic nuclear data and for materials and methods or reference

  1. Annual status report, 31 December 1983

    International Nuclear Information System (INIS)

    1984-04-01

    The research work of the Institute for Plasma Physics at Rijnhuizen during 1983 is surveyed. The Experimental Division reports on: pinches; turbulent heating in TORTUR, a small tokamak; numerical calculations on cold plasma blankets; electron cyclotron resonance heating; and, diagnostic subsystems. The Theoretical Division reports on: magnetohydrodynamics, wave dynamics and transport problems. Finally, the Department of Technology and Engineering reports on subjects as: high-power engineering, electronic control and computer hardware and software. (Auth.)

  2. 1982 annual status report: thermonuclear fusion technology

    International Nuclear Information System (INIS)

    1982-01-01

    The objective of this programme is to study the technological problems related to ''Post Jet'' experimental machines and, in a longer range, to assess the engineering aspects of Fusion Power Reactor Plants. According to the decision taken by the Council of Ministers on the JRC multiannual programme (1980-1983), the work performed on 1982 concerns four projects, namely: The Project 1: ''Fusion Reactor Studies''concerns mainly the NET (Next European Torus) studies which have been continued in the framework of the European participation to INTOR (INternational TOkamak Reactor). This represents a collaborative effort to design a major fusion experiment beyond the-upcoming generation of large tokamaks. The Project 2: ''Blanket Technology'' has the aim to investigate the behaviour of blanket materials in fusion conditions. The Project 3: ''Materials Sorting and Development'' has the aim to assess the mechanical properties and radiation damage of standard and advanced materials suited for structures, in particular for application as first wall of the fusion reactors. The Project 4: ''Cyclotron Operation and Experiments''has the task to exploit a cyclotron to simulate radiation damages to materials in a fusion ambient

  3. 1981 Annual Status Report: thermonuclear fusion technology

    International Nuclear Information System (INIS)

    1982-01-01

    The work perfomed on 1981 concerns four projects, namely: - The project 1: ''Reactor Studies''. During 1981 this activity was made in support to the European participation to the INTOR (INternational TOkamak Reactor) studies. This represents a collaborative effort among Europe, Japan; USA and USSR, under the auspices of IAEA, to design a major fusion experiment beyond the upcoming generation of large tokamaks. - The Project 2: ''Blanket Technology'' has the aim to investigate the behaviour of blanket materials in fusion conditions. - The Project 3: ''Materials Sorting and Development'' has the aim to assess the mechanical properties and radiation damage of standard and advanced materials suited for structures, in particular for application as first wall of the fusion reactors. - The Project 4: ''Cyclotron Operation and Experiments'' has the task to exploit a cyclotron to simulate radiation damages to materials in a fusion ambient

  4. Annual status report 31 December 1984

    International Nuclear Information System (INIS)

    1985-04-01

    The research work of the Institute for Plasma Physics at Rijnhuizen during 1984 is surveyed. The Experimental Division reports on: pinches; turbulent heating in TORTUR, a small tokamak; numerical calculations on cold plasma blankets; electron cyclotron resonance heating; and, diagnostic subsystems. The Theoretical Division reports on: magnetohydrodynamics, wave dynamics and transport problems. Finally, the groups of the Department of Technology and Engineering report on subjects as: design, construction and maintenance of instruments and apparatus, for instance the high-voltage supply of SPICA II and TORTUR III, electronic control and computer hardware and software

  5. 1980 Annual status report reactor safety

    International Nuclear Information System (INIS)

    1981-01-01

    The JRC reactor safety programme involves theoretical and experimental activities to analyse accidents and their consequences for LWRs and LMFBRs. The first project deals with the improvement and the application of methodologies for risk and reliability assessment. This activity involves the identification and modelling of accident sequences and events and the analysis of fault trees. In this project, the implementation of a centralized data bank system (European Reliability Data System) is foreseen, which should provide the information needed for risk assessment studies. In project 2 a major effort on LWRs is centered on the study of the loss-of-coolant accident following large, intermediate or small breaks of the primary circuit. These accidents are simulated out of pile in the LOBI facility. In project 3 a contribution is made to solve material problems and to provide data and calculation methods for end of life predictions of reactor components. It involves a contribution to the programme for the inspection of steel components (PISC) as well as the study of fracture and creep fatigue properties of stainless steel. In the project 4 and 5 a deterministic approach is adopted to solve some problems of large hypothetical accidents in an LMFBR. The calculation tools developed concern sodium thermohydraulics in fuel element bundles, fuel coolant interaction, whole core accident analysis, containment loading and response and post accident heat removal

  6. NERSC 2001 Annual Report; ANNUAL

    International Nuclear Information System (INIS)

    Hules, John

    2001-01-01

    The National Energy Research Scientific Computing Center (NERSC) is the primary computational resource for scientific research funded by the DOE Office of Science. The Annual Report for FY2001 includes a summary of recent computational science conducted on NERSC systems (with abstracts of significant and representative projects); information about NERSC's current systems and services; descriptions of Berkeley Lab's current research and development projects in applied mathematics, computer science, and computational science; and a brief summary of NERSC's Strategic Plan for 2002-2005

  7. Contributions of individual domains to function of the HIV-1 Rev response element.

    Science.gov (United States)

    O'Carroll, Ina P; Thappeta, Yashna; Fan, Lixin; Ramirez-Valdez, Edric A; Smith, Sean; Wang, Yun-Xing; Rein, Alan

    2017-08-16

    The HIV-1 Rev response element (RRE) is a 351-base element in unspliced and partially spliced viral RNA; binding of the RRE by the viral Rev protein induces nuclear export of RRE-containing RNAs, as required for virus replication. It contains one long, imperfect double helix (domain I), one branched domain (domain II) containing a high-affinity Rev-binding site, and two or three additional domains. We previously reported that the RRE assumes an "A" shape in solution and suggested that the location of the Rev binding sites in domains I and II, opposite each other on the two legs of the A, is optimal for Rev binding and explains Rev's specificity for RRE-containing RNAs. Using SAXS and a quantitative functional assay, we have now analyzed a panel of RRE mutants. All the results support the essential role of the A shape for RRE function. Moreover, they suggest that the distal portion of domain I and the three crowning domains all contribute to the maintenance of the A shape. Domains I and II are necessary and sufficient for substantial RRE function, provided they are joined by a flexible linker that allows the two domains to face each other. IMPORTANCE Retroviral replication requires that some of the viral RNAs transcribed in the cell nucleus be exported to the cytoplasm without being spliced. To achieve this, HIV-1 encodes a protein, Rev, which binds to a complex, highly structured element within viral RNA, the Rev Response Element (RRE), and escorts RRE-containing RNAs from the nucleus. We previously reported that the RRE is "A"-shaped and suggested that this architecture, with the 2 legs opposite one another, can explain the specificity of Rev for the RRE. We have analyzed the functional contributions of individual RRE domains, and now report that several domains contribute, with some redundancy, to maintenance of the overall RRE shape. The data strongly support the hypothesis that the opposed placement of the 2 legs is essential for RRE function. Copyright © 2017

  8. B23/nucleophosmin interacts with bovine immunodeficiency virus Rev protein and facilitates viral replication.

    Science.gov (United States)

    Passos-Castilho, Ana Maria; Marchand, Claude; Archambault, Denis

    2018-02-01

    The bovine immunodeficiency virus (BIV) Rev shuttling protein contains nuclear/nucleolar localization signals and nuclear import/export mechanisms that are novel among lentivirus Rev proteins. Several viral proteins localize to the nucleolus, which may play a role in processes that are essential to the outcome of viral replication. Although BIV Rev localizes to the nucleoli of transfected/infected cells and colocalizes with one of its major proteins, nucleophosmin (NPM1, also known as B23), the role of the nucleolus and B23 in BIV replication remains to be determined. Here, we demonstrate for the first time that BIV Rev interacts with nucleolar phosphoprotein B23 in cells. Using small interfering RNA (siRNA) technology, we show that depletion of B23 expression inhibits virus production by BIV-infected cells, indicating that B23 plays an important role in BIV replication. The interaction between Rev and B23 may represent a potential new target for the development of antiviral drugs against lentiviruses. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. SEM-REV: A sea test site for Marine Energy Converter

    International Nuclear Information System (INIS)

    Berhault, Christian; Le Crom, Izan; Le Bihan, Gerard

    2015-01-01

    Thanks to a main funding of Region des Pays de la Loire, the sea test site SEM-REV has been developed by Ecole Centrale de Nantes since 2007 to test both Wave Energy Converters and Floating Wind Turbine in real sea conditions. The sea test site is equipped with a set of oceanographic sensors and with an electric cable of 8 MW, connected to the French grid. The project is located close to Le Croisic, Western coast of France. SEM-REV is one of the main test facilities operated by Ecole Centrale de Nantes to support MRE technologies development. After presenting the initial motivations of the SEM-REV development, the paper describes, in parts 1 and 2, the complete administrative and technical processes that were followed to reach SEM-REV commissioning in 2014. The third part is focused on the exploitation process, including technical and contractual specifications imposed to the MRE developers for installation, tests and decommissioning phases. Some words are given also on the R and D projects using the SEM-REV in-situ monitoring system: prediction of environmental conditions, bio-fooling, acoustic impact. Even if operational phase is not started, expected extensions of the tests site are listed. (authors)

  10. Ultraviolet-induced reversion of cyc1 alleles in radiation-sensitive strains of yeast. III. rev 3 mutant strains

    International Nuclear Information System (INIS)

    Lawrence, C.W.; Crhistensen, R.B.

    1979-01-01

    The role of rev3 gene function in uv-induced mutagenesis in the yeast Saccharomyces cerevisiae has been examined by determining the reversion of 12 well-defined cyc1 mutations in diploid strains homozygous for the rev3-1 or rev3-3 allale. The 12 cyc1 alleles include one ochre, one amber, four initiation, two proline missense, and four frameshift mutations. We find that the rev3 mutations reduce the frequency of UV-induced reversion of all of the cyc1 alleles, though different classes of alleles respond to a different extent. These results imply that the rev3 gene function is required for the production of a wide variety of mutational events, though probably not all, and show that each of the three rev loci have different mutational phenotypes. Such diverse phenotypes are not predicted by the unitary model for bacterial mutagenes, suggesting that this is at best an incomplete description of eukaryotic mutagenesis

  11. Innocuity and immune response to Brucella melitensis Rev.1 vaccine in camels (Camelus dromedarius

    Directory of Open Access Journals (Sweden)

    A. Benkirane

    2014-10-01

    Full Text Available A field trial was conducted in a camel brucellosis-free herd to evaluate antibody response to the Brucella melitensis Rev.1 vaccine in camels and assess shedding of the vaccine strain in milk. Twenty eight camels were divided into four groups according to their age and vaccination route. Groups A (n=3 and B (n=3 consisted of non-pregnant lactating female camels, vaccinated through subcutaneous and conjunctival routes, respectively. Groups C (n=10 consisted of 8-11 months old calves vaccinated through conjunctival route. The rest of the herd (n=12 composed of female and young camels were not vaccinated and were considered as the control group. Each animal from groups A, B and C was given the recommended dose of 2 x 109 colony forming units of Rev.1 vaccine irrespective of age or route of vaccination. Blood samples were collected from all the animals at the time of vaccination and at weekly, bi-weekly and monthly interval until 32 weeks post vaccination and from controls at weeks 8 and 24. The serological tests used were modified Rose Bengal Test, sero-agglutination test, and an indirect Enzyme Linked Immunosorbent Assay. Milk samples were collected from all vaccinated female camels and tested for the presence of Rev.1 vaccine strain. Most vaccinated animals started to show an antibody response at week 2 and remained positive until week 16. By week 20 post-vaccination all animals in the three groups were tested negative for Brucella antibodies. Bacteriological analysis of milk samples did not allow any isolation of Brucella melitensis. All samples were found Brucella negative in PCR analysis. The results of this study indicate that the Rev.1 vaccine induces seroconversion in camels. Rev.1 vaccine strain is not excreted in the milk of camels. These findings are promising as to the safe use of the Rev.1 vaccine in camels.

  12. Annual report

    International Nuclear Information System (INIS)

    1986-01-01

    This is the thirty-ninth annual report of the Atomic Energy Control Board. The period covered by this report is the year ending March 31, 1986. The Atomic Energy Control Board (AECB) was established in 1946, by the Atomic Energy Control Act (AEC Act), (Revised Statues of Canada (R.S.C.) 1970 cA19). It is a departmental corporation (Schedule B) within the meaning and purpose of the Financial Administration Act. The AECB controls the development, application and use of atomic energy in Canada, and participates on behalf of Canada in international measures of control. The AECB is also repsonsible for the administration of the Nuclear Liability Act, (R.S.C. 1970 c29 1st Supp) as amended, including the designation of nuclear installations and the prescription of basic insurance to be carried by the operators of such nuclear installations. The AECB reports to Parliament through a designated Minister, currently the Minister of Energy, Mines and Resources

  13. Unprecedented NES non-antagonistic inhibitor for nuclear export of Rev from Sida cordifolia.

    Science.gov (United States)

    Tamura, Satoru; Kaneko, Masafumi; Shiomi, Atsushi; Yang, Guang-Ming; Yamaura, Toshiaki; Murakami, Nobutoshi

    2010-03-15

    Bioassay-guided separation from the MeOH extract of the South American medicinal plant Sida cordifolia resulted in isolation of (10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid (1) as an unprecedented NES non-antagonistic inhibitor for nuclear export of Rev. This mechanism of action was established by competitive experiment by the biotinylated probe derived from leptomycin B, the known NES antagonistic inhibitor. Additionally, structure-activity relationship analysis by use of the synthesized analogs clarified cooperation of several functionalities in the Rev-export inhibitory activity of 1. Copyright 2010 Elsevier Ltd. All rights reserved.

  14. Administrative Circular No. 22B (Rev. 2) - Compensation for hours of long-term shift work

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 22B (Rev. 2) entitled "Compensation for hours of long-term shift work",  approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208538.   This revised circular cancels and replaces Administrative Circular No. 22B (Rev. 1) also entitled "Compensation for hours of long-term shift work" of March 2011. This document contains minor changes to reflect the new career structure. This circular will enter into force on 1st September 2016.

  15. Administrative Circular No. 13 (Rev. 4) - Guarantees for representatives of the personnel

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 13 (Rev. 4) entitled "Guarantees for representatives of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208527.   This revised circular cancels and replaces Administrative Circular No. 13 (Rev. 3) also entitled "Guarantees for representatives of the personnel" of January 2014. This document contains a single change to reflect the terminology under the new career structure: the term "career path" is replaced by "grade". This circular will enter into force on 1st September 2016.

  16. Empirical investigation of wind farm blockage effects in Horn Rev 1 offshore wind farm

    DEFF Research Database (Denmark)

    Mitraszewski, Karol; Hansen, Kurt Schaldemose; Nygaard, Nicolai

    We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds and stabi......We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds...

  17. RevTrans: multiple alignment of coding DNA from aligned amino acid sequences

    DEFF Research Database (Denmark)

    Wernersson, Rasmus; Pedersen, Anders Gorm

    2003-01-01

    The simple fact that proteins are built from 20 amino acids while DNA only contains four different bases, means that the 'signal-to-noise ratio' in protein sequence alignments is much better than in alignments of DNA. Besides this information-theoretical advantage, protein alignments also benefit...... proteins. It is therefore preferable to align coding DNA at the amino acid level and it is for this purpose we have constructed the program RevTrans. RevTrans constructs a multiple DNA alignment by: (i) translating the DNA; (ii) aligning the resulting peptide sequences; and (iii) building a multiple DNA...

  18. Rev1 Recruits Ung to Switch Regions and Enhances dU Glycosylation for Immunoglobulin Class Switch DNA Recombination

    Directory of Open Access Journals (Sweden)

    Hong Zan

    2012-11-01

    Full Text Available By diversifying the biological effector functions of antibodies, class switch DNA recombination (CSR plays a critical role in the maturation of the immune response. It is initiated by activation-induced cytidine deaminase (AID-mediated deoxycytosine deamination, yielding deoxyuridine (dU, and dU glycosylation by uracil DNA glycosylase (Ung in antibody switch (S region DNA. Here we showed that the translesion DNA synthesis polymerase Rev1 directly interacted with Ung and targeted in an AID-dependent and Ung-independent fashion the S regions undergoing CSR. Rev1−/− Ung+/+ B cells reduced Ung recruitment to S regions, DNA-dU glycosylation, and CSR. Together with an S region spectrum of mutations similar to that of Rev1+/+ Ung−/− B cells, this suggests that Rev1 operates in the same pathway as Ung, as emphasized by further decreased CSR in Rev1−/− Msh2−/− B cells. Rescue of CSR in Rev1−/− B cells by a catalytically inactive Rev1 mutant shows that the important role of Rev1 in CSR is mediated by Rev1’s scaffolding function, not its enzymatic function.

  19. Metabolism and apoptotic properties of elevated ceramide in HT29(rev) cells

    NARCIS (Netherlands)

    Veldman, R J; Klappe, K; Hoekstra, D; Kok, J W

    1998-01-01

    Ceramide (Cer) has been implicated in the regulation of apoptosis. In this study, we elevated cellular Cer levels in human colon-carcinoma (HT29(rev)) cells by incubating the cells in the presence of bacterial sphingomyelinase (bSMase) or, alternatively, in the presence of C2-Cer, a short-chain

  20. Material Trends ( From M.Imada, A. Fujimori, and Y. Tokura, Rev ...

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Material Trends ( From M.Imada, A. Fujimori, and Y. Tokura, Rev. Mod. Phys. 70, 1039 (1998) ). Differences due to changes in cation radius causing bending of Mn-O-Mn bonds. Extreme sensitivity to small changes.

  1. 48 CFR 53.301-18 - SF 18 (Rev. 6/95), Request for Quotations.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false SF 18 (Rev. 6/95), Request for Quotations. 53.301-18 Section 53.301-18 Federal Acquisition Regulations System FEDERAL ACQUISITION... for Quotations. EC01MY91.002 [60 FR 34763, July 3, 1995] ...

  2. Determining the REV for Fracture Rock Mass Based on Seepage Theory

    Directory of Open Access Journals (Sweden)

    Lili Zhang

    2017-01-01

    Full Text Available Seepage problems of the fractured rock mass have always been a heated topic within hydrogeology and engineering geology. The equivalent porous medium model method is the main method in the study of the seepage of the fractured rock mass and its engineering application. The key to the method is to determine a representative elementary volume (REV. The FractureToKarst software, that is, discrete element software, is a main analysis tool in this paper and developed by a number of authors. According to the standard of rock classification established by ISRM, this paper aims to discuss the existence and the size of REV of fractured rock masses with medium tractility and provide a general method to determine the existence of REV. It can be gleaned from the study that the existence condition of fractured rock mass with medium tractility features average fracture spacing smaller than 0.6 m. If average fracture spacing is larger than 0.6 m, there is no existence of REV. The rationality of the model is verified by a case study. The present research provides a method for the simulation of seepage field in fissured rocks.

  3. Annual report 2003-2004

    International Nuclear Information System (INIS)

    2004-01-01

    The annual report for the year 2003-2004 has been compiled, which offers concise description of tasks achieved and status of on going efforts pertaining to PAEC (Pakistan Atomic Commission) programme. The tasks description are as: highlights of various projects, nuclear power plants, physical sciences and engineering, biosciences, nuclear minerals, human resource development, projects, international relations. At the end of this report financial position of PAEC and list of publication list is also available. (A.B.)

  4. Annual Report 2000-2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The annual report for the year 2000-2001 has been compiled, which offers concise description of tasks achieved and status of on going efforts pertaining to PAEC (Pakistan Atomic Commission) programme. The tasks description are as: highlights of various projects, nuclear power plants, physical sciences and engineering, biosciences, nuclear minerals, human resource development, projects, international relations. At the end of this report financial position of PAEC and list of publication is also available. (A.B.)

  5. Annual Report 2000-2001

    International Nuclear Information System (INIS)

    2002-01-01

    The annual report for the year 2000-2001 has been compiled, which offers concise description of tasks achieved and status of on going efforts pertaining to PAEC (Pakistan Atomic Commission) programme. The tasks description are as: highlights of various projects, nuclear power plants, physical sciences and engineering, biosciences, nuclear minerals, human resource development, projects, international relations. At the end of this report financial position of PAEC and list of publication is also available. (A.B.)

  6. Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein-Protein Interaction.

    Science.gov (United States)

    Sail, Vibhavari; Rizzo, Alessandro A; Chatterjee, Nimrat; Dash, Radha C; Ozen, Zuleyha; Walker, Graham C; Korzhnev, Dmitry M; Hadden, M Kyle

    2017-07-21

    Translesion synthesis (TLS) is an important mechanism through which proliferating cells tolerate DNA damage during replication. The mutagenic Rev1/Polζ-dependent branch of TLS helps cancer cells survive first-line genotoxic chemotherapy and introduces mutations that can contribute to the acquired resistance so often observed with standard anticancer regimens. As such, inhibition of Rev1/Polζ-dependent TLS has recently emerged as a strategy to enhance the efficacy of first-line chemotherapy and reduce the acquisition of chemoresistance by decreasing tumor mutation rate. The TLS DNA polymerase Rev1 serves as an integral scaffolding protein that mediates the assembly of the active multiprotein TLS complexes. Protein-protein interactions (PPIs) between the C-terminal domain of Rev1 (Rev1-CT) and the Rev1-interacting region (RIR) of other TLS DNA polymerases play an essential role in regulating TLS activity. To probe whether disrupting the Rev1-CT/RIR PPI is a valid approach for developing a new class of targeted anticancer agents, we designed a fluorescence polarization-based assay that was utilized in a pilot screen for small molecule inhibitors of this PPI. Two small molecule scaffolds that disrupt this interaction were identified, and secondary validation assays confirmed that compound 5 binds to Rev1-CT at the RIR interface. Finally, survival and mutagenesis assays in mouse embryonic fibroblasts and human fibrosarcoma HT1080 cells treated with cisplatin and ultraviolet light indicate that these compounds inhibit mutagenic Rev1/Polζ-dependent TLS in cells, validating the Rev1-CT/RIR PPI for future anticancer drug discovery and identifying the first small molecule inhibitors of TLS that target Rev1-CT.

  7. Annual Report 2010

    Energy Technology Data Exchange (ETDEWEB)

    Michalik, J; Smulek, W; Godlewska-Para, E [ed.

    2011-07-01

    The Annual Report of the Institute of Nuclear Chemistry and Technology (Warsaw, Poland) describes achievements of the Institute in 2010 obtained by three Centres and eight Laboratories, namely: (1) Centre for Radiation Research and Technology, (2) Centre of Radiochemistry and Nuclear Chemistry, (3) Centre of Radiobiology and Biological Dosimetry, (4) Laboratory of Nuclear Analytical Methods, (5) Laboratory of Material Research, (6) Pollution Control Technologies Laboratory, (7) Laboratory of Stable and Environmental Isotopes, (8) Laboratory for Measurements of Technological Doses, (9) Laboratory for Detection of Irradiated Food and (10) Laboratory of Nuclear Control Systems and Methods. In total - 32 detailed papers prepared by the Institute workers and collaborating scientists are presented. General information on the Institute status, personnel activity, international cooperation and publications are presented.

  8. Annual Report 2010

    International Nuclear Information System (INIS)

    Michalik, J.; Smulek, W.; Godlewska-Para, E.

    2011-01-01

    The Annual Report of the Institute of Nuclear Chemistry and Technology (Warsaw, Poland) describes achievements of the Institute in 2010 obtained by three Centres and eight Laboratories, namely: (1) Centre for Radiation Research and Technology, (2) Centre of Radiochemistry and Nuclear Chemistry, (3) Centre of Radiobiology and Biological Dosimetry, (4) Laboratory of Nuclear Analytical Methods, (5) Laboratory of Material Research, (6) Pollution Control Technologies Laboratory, (7) Laboratory of Stable and Environmental Isotopes, (8) Laboratory for Measurements of Technological Doses, (9) Laboratory for Detection of Irradiated Food and (10) Laboratory of Nuclear Control Systems and Methods. In total - 32 detailed papers prepared by the Institute workers and collaborating scientists are presented. General information on the Institute status, personnel activity, international cooperation and publications are presented.

  9. Annual Report 2009

    International Nuclear Information System (INIS)

    Michalik, J.; Smulek, W.; Godlewska-Para, E.

    2010-01-01

    The Annual Report of the Institute of Nuclear Chemistry and Technology (Warsaw, Poland) describes achievements of the Institute in 2009 obtained in ten laboratories: (1) Centre for Radiation Research and Technology, (2) Centre of Radiochemistry and Nuclear Chemistry, (3) Centre of Radiobiology and Biological Dosimetry, (4) Laboratory of Nuclear Analytical Methods, (5) Laboratory of Material Research, (6) Pollution Control Technologies Laboratory, (7) Laboratory of Stable and Environmental Isotopes, (8) Laboratory for Measurements of Technological Doses, (9) Laboratory for Detection of Irradiated Food, (10) Laboratory of Nuclear Control Systems and Methods. In total - 49 detailed papers prepared by the Institute staff and collaborating scientists are presented. General information on the Institute status, personnel activity, international cooperation and publications are also given.

  10. Molecular typing of Brucella melitensis endemic strains and differentiation from the vaccine strain Rev-1.

    Science.gov (United States)

    Noutsios, Georgios T; Papi, Rigini M; Ekateriniadou, Loukia V; Minas, Anastasios; Kyriakidis, Dimitrios A

    2012-03-01

    In the present study forty-four Greek endemic strains of Br. melitensis and three reference strains were genotyped by Multi locus Variable Number Tandem Repeat (ML-VNTR) analysis based on an eight-base pair tandem repeat sequence that was revealed in eight loci of Br. melitensis genome. The forty-four strains were discriminated from the vaccine strain Rev-1 by Restriction Fragment Length Polymorphism (RFLP) and Denaturant Gradient Gel Electrophoresis (DGGE). The ML-VNTR analysis revealed that endemic, reference and vaccine strains are genetically closely related, while most of the loci tested (1, 2, 4, 5 and 7) are highly polymorphic with Hunter-Gaston Genetic Diversity Index (HGDI) values in the range of 0.939 to 0.775. Analysis of ML-VNTRs loci stability through in vitro passages proved that loci 1 and 5 are non stable. Therefore, vaccine strain can be discriminated from endemic strains by allele's clusters of loci 2, 4, 6 and 7. RFLP and DGGE were also employed to analyse omp2 gene and reveled different patterns among Rev-1 and endemic strains. In RFLP, Rev-1 revealed three fragments (282, 238 and 44 bp), while endemic strains two fragments (238 and 44 bp). As for DGGE, the electrophoretic mobility of Rev-1 is different from the endemic strains due to heterologous binding of DNA chains of omp2a and omp2b gene. Overall, our data show clearly that it is feasible to genotype endemic strains of Br. melitensis and differentiate them from vaccine strain Rev-1 with ML-VNTR, RFLP and DGGE techniques. These tools can be used for conventional investigations in brucellosis outbreaks.

  11. Quarterly, Bi-annual and Annual Reports

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Quarterly, Bi-annual and Annual Reports are periodic reports issued for public release. For the deep set fishery these reports are issued quarterly and anually....

  12. Offshore wind farms in the local community - a survey at Horns Rev wind farm. Background report; Havvindmoeller i lokalomraedet - en undersoegelse ved Horns Rev havmoellepark. Baggrundsrapport

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, S.

    2005-07-15

    This report is part of a socio-economic project about offshore wind farms' influence on the local community. The project is part of the monitoring programme in connection with the establishment of the offshore wind farms at Horns Rev and Nysted. The socio-economic project consists of a sociological and an environment-economic project. This report is part of the sociological project which has the purpose of identifying attitudes towards the wind farm before and after the erection with a view to identify possible changes in opinions and reasons for these changes. (BA)

  13. MicroRNA-340 inhibits the proliferation and promotes the apoptosis of colon cancer cells by modulating REV3L

    Science.gov (United States)

    Arivazhagan, Roshini; Lee, Jaesuk; Bayarsaikhan, Delger; Kwak, Peter; Son, Myeongjoo; Byun, Kyunghee; Salekdeh, Ghasem Hosseini; Lee, Bonghee

    2018-01-01

    DNA Directed Polymerase Zeta Catalytic Subunit (REV3L) has recently emerged as an important oncogene. Although the expressions of REV3L are similar in normal and cancer cells, several mutations in REV3L have been shown to play important roles in cancer. These mutations cause proteins misfolding and mislocalization, which in turn alters their interactions and biological functions. miRNAs play important regulatory roles during the progression and metastasis of several human cancers. This study was undertaken to determine how changes in the location and interactions of REV3L regulate colon cancer progression. REV3L protein mislocalization confirmed from the immunostaining results and the known interactions of REV3L was found to be broken as seen from the PLA assay results. The mislocalized REV3L might interact with new proteins partners in the cytoplasm which in turn may play role in regulating colon cancer progression. hsa-miR-340 (miR-340), a microRNA down-regulated in colon cancer, was used to bind to and downregulate REV3L, and found to control the proliferation and induce the apoptosis of colon cancer cells (HCT-116 and DLD-1) via the MAPK pathway. Furthermore, this down-regulation of REV3L also diminished colon cancer cell migration, and down-regulated MMP-2 and MMP-9. Combined treatment of colon cancer cells with miR-340 and 5-FU enhanced the inhibitory effects of 5-FU. In addition, in vivo experiments conducted on nude mice revealed tumor sizes were smaller in a HCT-116-miR-340 injected group than in a HCT-116-pCMV injected group. Our findings suggest mutations in REV3L causes protein mislocalization to the cytoplasm, breaking its interaction and is believed to form new protein interactions in cytoplasm contributing to colon cancer progression. Accordingly, microRNA-340 appears to be a good candidate for colon cancer therapy. PMID:29435169

  14. Identification of Brucella melitensis Rev.1 vaccine-strain genetic markers: Towards understanding the molecular mechanism behind virulence attenuation.

    Science.gov (United States)

    Issa, Mohammad Nouh; Ashhab, Yaqoub

    2016-09-22

    Brucella melitensis Rev.1 is an avirulent strain that is widely used as a live vaccine to control brucellosis in small ruminants. Although an assembled draft version of Rev.1 genome has been available since 2009, this genome has not been investigated to characterize this important vaccine. In the present work, we used the draft genome of Rev.1 to perform a thorough genomic comparison and sequence analysis to identify and characterize the panel of its unique genetic markers. The draft genome of Rev.1 was compared with genome sequences of 36 different Brucella melitensis strains from the Brucella project of the Broad Institute of MIT and Harvard. The comparative analyses revealed 32 genetic alterations (30 SNPs, 1 single-bp insertion and 1 single-bp deletion) that are exclusively present in the Rev.1 genome. In silico analyses showed that 9 out of the 17 non-synonymous mutations are deleterious. Three ABC transporters are among the disrupted genes that can be linked to virulence attenuation. Out of the 32 mutations, 11 Rev.1 specific markers were selected to test their potential to discriminate Rev.1 using a bi-directional allele-specific PCR assay. Six markers were able to distinguish between Rev.1 and a set of control strains. We succeeded in identifying a panel of 32 genome-specific markers of the B. melitensis Rev.1 vaccine strain. Extensive in silico analysis showed that a considerable number of these mutations could severely affect the function of the associated genes. In addition, some of the discovered markers were able to discriminate Rev.1 strain from a group of control strains using practical PCR tests that can be applied in resource-limited settings. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Administrative Cicular No. 31 (Rev. 2) - International indemnity and non-resident allowance

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 31 (Rev. 2) entitled "International indemnity and non-resident allowance", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 23 June 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208547.   This revised circular cancels and replaces Administrative Circular No. 31 (Rev. 1) also entitled "International indemnity and non-resident allowance" of October 2007. The main changes reflect the decision taken in the framework of the five-yearly review to extend eligibility for international indemnity to all staff members, as well to introduce a distinction between current staff members and those recruited as from 1st September 2016. For the latter, the international indemnity will be calculated as a percentage of the minimum salary of the grade into which they are recruited; the amount granted to the former will not change, and is now expressed ...

  16. Administrative Circular No. 11 (Rev. 3) - Categories of members of the personnel

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 11 (Rev. 3) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 3 July 2014 and entering into force on 1 September 2014, is available on the intranet site of the Human Resources Department.   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel” of January 2013. The circular was revised in order to include a minor adjustment of the determination of required period of break in the payment of subsistence allowance to certain categories of associated members of the personnel (taking account of possible technical means of control). Furthermore, the possibility of traineeships of long duration was restricted to cases in which the traineeship is awarded pursuant to an agreement between CERN and a...

  17. Administrative Circular No. 13 (Rev. 3) - Guarantees for representatives of the personnel

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 13 (Rev. 3) entitled “Guarantees for representatives of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 13 (Rev. 2) entitled “Guarantees for members of the personnel holding representative office” of November 1992. The circular was revised in order to adapt the time given to the representatives of the personnel to perform their elective mandate and to ensure more transparency in their activities, by indicating, inter alia, the percentage of time worked in the framework of their mandate, as well as the training, activities and ensuing results. Department Head Office HR Department

  18. Administrative circular n°23 (Rev. 3) – Special working hours

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 23 (Rev. 3) entitled “Special working hours”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 October 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to staff members and fellows. It cancels and replaces Administrative Circular No. 23 (Rev. 2) entitled “Special working hours” of December 2008. Paragraph 6 a) of Annex II of this circular was revised following the modification of Article III 1.04 of the Staff Regulations approved by Council on 14 December 2012. The modification serves to adapt the minimum rest time to the fact that, in case of rapidly alternating shifts, a maximum of seven consecutive shifts may be performed. Department Head Office HR Department

  19. Administrative circular n°11 (REV. 2) – Categories of members of the personnel

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 May 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department. This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 1) entitled “Categories of members of the personnel” of January 1997 as regards all contracts of members of the personnel issued on or after 1 January 2013. The circular was revised in order to take into account developments since the last revision of the categories of personnel in 1997 as well as the needs of the Organization and collaborating institutes. In particular, it introduces a new system for distinguishing categories of associated members of the personnel, namely with regard to the purpo...

  20. Administrative circular No. 20 (Rev. 2) – Use of private vehicules for journeys on official duty

    CERN Multimedia

    HR Department

    2011-01-01

    Administrative Circular No. 20 (Rev. 2) entitled "Use of private vehicles for journeys on official duty", adopted following discussion in the Standing Concertation Committee meeting of 21 September 2010 and entering into force on 1 January 2011, is available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 20 (Rev. 1) entitled "Use of private vehicles on official duty" of April 1993. This new version introduces, in particular, the payment of a kilometer allowance in case of emergency during standby duty or when on call and a simplified calculation of the allowance for journeys between sites. This circular also clarifies the type of permitted private vehicles. Department Head Office  

  1. Rev and Rex proteins of human complex retroviruses function with the MMTV Rem-responsive element

    Directory of Open Access Journals (Sweden)

    Dudley Jaquelin P

    2009-02-01

    Full Text Available Abstract Background Mouse mammary tumor virus (MMTV encodes the Rem protein, an HIV Rev-like protein that enhances nuclear export of unspliced viral RNA in rodent cells. We have shown that Rem is expressed from a doubly spliced RNA, typical of complex retroviruses. Several recent reports indicate that MMTV can infect human cells, suggesting that MMTV might interact with human retroviruses, such as human immunodeficiency virus (HIV, human T-cell leukemia virus (HTLV, and human endogenous retrovirus type K (HERV-K. In this report, we test whether the export/regulatory proteins of human complex retroviruses will increase expression from vectors containing the Rem-responsive element (RmRE. Results MMTV Rem, HIV Rev, and HTLV Rex proteins, but not HERV-K Rec, enhanced expression from an MMTV-based reporter plasmid in human T cells, and this activity was dependent on the RmRE. No RmRE-dependent reporter gene expression was detectable using Rev, Rex, or Rec in HC11 mouse mammary cells. Cell fractionation and RNA quantitation experiments suggested that the regulatory proteins did not affect RNA stability or nuclear export in the MMTV reporter system. Rem had no demonstrable activity on export elements from HIV, HTLV, or HERV-K. Similar to the Rem-specific activity in rodent cells, the RmRE-dependent functions of Rem, Rev, or Rex in human cells were inhibited by a dominant-negative truncated nucleoporin that acts in the Crm1 pathway of RNA and protein export. Conclusion These data argue that many retroviral regulatory proteins recognize similar complex RNA structures, which may depend on the presence of cell-type specific proteins. Retroviral protein activity on the RmRE appears to affect a post-export function of the reporter RNA. Our results provide additional evidence that MMTV is a complex retrovirus with the potential for viral interactions in human cells.

  2. Effects on birds of an offshore wind park at Horns Rev: Environmental impact assessment

    Energy Technology Data Exchange (ETDEWEB)

    Noer, H.; Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I. [DMU, Dept. of Coastal Zone Ecology (Denmark)

    2000-07-01

    This report presents the technical background to the ornithological environmental impact assessment for the construction of an offshore windpark at Horns Rev, 14 km west-south-west of Blaevandshuk, Denmark. Construction of the park is planned to commence in 2001. The park will consist of c. 80 wind turbines, each of at least 1.8 MW, and cover an area of 27.5 km{sup 2} (including the 200 m exclusion zone around the park). (au)

  3. Determination of Geometrical REVs Based on Volumetric Fracture Intensity and Statistical Tests

    Directory of Open Access Journals (Sweden)

    Ying Liu

    2018-05-01

    Full Text Available This paper presents a method to estimate a representative element volume (REV of a fractured rock mass based on the volumetric fracture intensity P32 and statistical tests. A 150 m × 80 m × 50 m 3D fracture network model was generated based on field data collected at the Maji dam site by using the rectangular window sampling method. The volumetric fracture intensity P32 of each cube was calculated by varying the cube location in the generated 3D fracture network model and varying the cube side length from 1 to 20 m, and the distribution of the P32 values was described. The size effect and spatial effect of the fractured rock mass were studied; the P32 values from the same cube sizes and different locations were significantly different, and the fluctuation in P32 values clearly decreases as the cube side length increases. In this paper, a new method that comprehensively considers the anisotropy of rock masses, simplicity of calculation and differences between different methods was proposed to estimate the geometrical REV size. The geometrical REV size of the fractured rock mass was determined based on the volumetric fracture intensity P32 and two statistical test methods, namely, the likelihood ratio test and the Wald–Wolfowitz runs test. The results of the two statistical tests were substantially different; critical cube sizes of 13 m and 12 m were estimated by the Wald–Wolfowitz runs test and the likelihood ratio test, respectively. Because the different test methods emphasize different considerations and impact factors, considering a result that these two tests accept, the larger cube size, 13 m, was selected as the geometrical REV size of the fractured rock mass at the Maji dam site in China.

  4. Losers, Food, and Sex. Clerical Masculinity in the BBC Sitcom Rev.

    Directory of Open Access Journals (Sweden)

    Alexander Ornella

    2016-11-01

    Full Text Available Clerical masculinities, much like their lay/secular counterparts, often appear unchang¬ing because they are the products of naturalization processes. Clerical masculinities, however, are far from stable, for they live and breathe the dynamics of both their socio-religious context and their secular “others”. The BBC sitcom Rev. (BBC2, UK 2010–2014 is a refreshing take on the everyday life and problems of a vicar in the Church of England trying to avoid stereotypes that often come with clerical roles. Rev. (2010–2014 can be interpreted as an attempt to explore the negotiation processes of masculinity within an institution that is involved in the “production” of religion and gender roles. It shows that being a man in an institutional setting is as much a perfor¬mance as it is a more or less successful negotiation of other people’s expectations and one’s own worldview. In particular, the main male clerical characters in Rev. (2010– 2014 inhabit a position of power but all have their flaws. They can best be understood as losers whose clash with masculine systems renders them more human.

  5. Guidance and considerations for implementation of INFCIRC/225/Rev.3, the physical protection of nuclear material

    International Nuclear Information System (INIS)

    1997-09-01

    The Physical Protection of Nuclear Material, INFCIRC/225/Rev.3, provides recommendations for the physical protection of nuclear material against theft in use, storage and transport, whether national or international and whether peaceful or military, and contains provisions relating to the sabotage of nuclear material or facilities. The recommendations contained in INFCIRC/225/Rev.3 detail the elements that should be included in a State's system of physical protection. It also recognizes the adverse health and safety consequences arising from the theft of nuclear material and the sabotage of nuclear material or facilities. Most industrial and developing countries use these recommendations to some extent in the establishment and operation of their physical protection systems. Although INFCIRC/225/Rev.3 provides recommendations for protecting materials and facilities from theft or sabotage, it does not provide in-depth details for these recommendations. In June 1996, the IAEA convened a consultants meeting to consider this matter. This report is the result of continuing discussions and drafts over a period of nine months. The intent of this guidance is to provide a broader basis for relevant State organizations to prescribe appropriate requirements for the use of nuclear materials which are compatible with accepted international practice

  6. Status for investigations of birds and proposals for further investigations of birds in 2002 and 2003 for Horns Rev offshore wind farm; Status for fugleundersoegelser samt forslag til opfoelgende fugleundersoegelser i 2002 og 2003 for Horns Rev vindmoellepark

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-09-15

    The purpose of the investigations of birds is to establish a knowledge and data base that can make possible to enlighten the extent and character of potential influences the offshore wind farm might have on the birds. The potential influences the offshore wind farm might have on birds include: a) modification of the habitat, b) collision effects, and c) disturbances. (BA)

  7. Topical report review status

    International Nuclear Information System (INIS)

    1982-08-01

    A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility. This status report is published primarily for internal NRC use in managing the topical report program, but is also used by NRC to advise the industry of report review status

  8. Topical report review status

    International Nuclear Information System (INIS)

    1983-01-01

    A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility. This status report is published primarily for internal NRC use in managing the topical report program, but is also used by NRC to advise the industry of report review status

  9. JAEA Takasaki annual report 2006

    International Nuclear Information System (INIS)

    Tanaka, Shigeru

    2008-03-01

    JAEA Takasaki annual report 2006 describes research and development activities performed from April 1, 2006 to March 31, 2007 with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and electron/gamma-ray irradiation facilities (an electron accelerator and three 60 Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) space, nuclear and energy engineering, 2) environmental conservation and resource security, 3) biotechnology and medical application, and 4) advanced materials, analysis and novel technology. This annual report contains 186 reports consisting of 178 research papers and 8 status reports on operation/maintenance of the irradiation facilities described above, and a list of publications, related press-releases, TV programs, patents, and the type of research collaborations as Appendices. (author)

  10. JAEA Takasaki annual report 2010

    International Nuclear Information System (INIS)

    Kojima, Takuji

    2012-01-01

    JAEA Takasaki annual report 2010 describes research and development activities performed from April 1, 2010 to March 31, 2011 with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and electron/gamma-ray irradiation facilities (an electron accelerator and three 60 Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) Space, Nuclear and Energy Engineering, 2) Environmental Conservation and Resource Exploitation, 3) Medical and Biotechnological Application, and 4) Advanced Materials, Analysis and Novel Technology. This annual report contains 159 reports consisting of 151 research papers and 8 status reports on operation/maintenance of the irradiation facilities described above, and a list of publications, patents, related press-releases, television broadcasting, and the type of research collaborations as Appendices. (author)

  11. JAEA Takasaki annual report 2012

    International Nuclear Information System (INIS)

    Kojima, Takuji

    2014-03-01

    JAEA Takasaki annual report 2012 describes research and development activities performed from April 1, 2012 to March 31, 2013 mainly with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and electron/gamma-ray irradiation facilities (an electron accelerator and three 60 Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) Space, Nuclear and Energy Engineering, 2) Environmental Conservation and Resource Exploitation, 3) Medical and Biotechnological Application, and 4) Advanced Materials, Analysis and Novel Technology. This annual report contains 164 reports consisting of 156 research papers and 8 status reports on operation/maintenance of the irradiation facilities described above, a list of publications, patents, related press-releases, television broadcasting, and the type of research collaborations as appendices. (author)

  12. JAEA Takasaki annual report 2011

    International Nuclear Information System (INIS)

    Kojima, Takuji

    2013-01-01

    JAEA Takasaki annual report 2011 describes research and development activities performed from April 1, 2011 to March 31, 2012 with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and electron/gamma-ray irradiation facilities (an electron accelerator and three 60 Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) Space, Nuclear and Energy Engineering, 2) Environmental Conservation and Resource Exploitation, 3) Medical and Biotechnological Application, and 4) Advanced Materials, Analysis and Novel Technology for Facilities. This annual report contains 158 reports consisting of 150 research papers and 8 status reports on operation/maintenance of the irradiation facilities described above, and a list of publications, patents, related press-releases, television broadcasting, and the type of research collaborations as appendices. (author)

  13. JAEA Takasaki annual report 2005

    International Nuclear Information System (INIS)

    Ohara, Yoshihiro

    2007-02-01

    JAEA Takasaki annual report 2005 describes research and development activities performed from April 1, 2005 to March 31, 2006 with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and those in a recent few years with electron/gamma-ray irradiation facilities (an electron accelerator and three 60 Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) nuclear and energy engineering, 2) environmental conservation and resource security, 3) biotechnology and medical application, 4) advanced materials, analysis and novel technology. This annual report contains 182 reports consisting of 174 research papers and 8 status reports on operation/maintenance of above irradiation facilities, and a list of publications, related press-releases, IV programs, patents, and the type of research collaborations as Appendices. (author)

  14. JAEA Takasaki annual report 2009

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Shigeru [Japan Atomic Energy Agency, Takasaki Advanced Radiation Research Inst., Takasaki, Gunma (Japan)

    2011-01-15

    JAEA Takasaki annual report 2009 describes research and development activities performed from April 1, 2009 to March 31, 2010 with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and electron/gamma-ray irradiation facilities (an electron accelerator and three {sup 60}Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) space, nuclear and energy engineering, 2) environmental conservation and resource security, 3) biotechnology and medical application, and 4) advanced materials, analysis and novel technology. This annual report contains 165 reports consisting of 157 research papers and 8 status reports on operation/maintenance of the irradiation facilities described above, and a list of publications, patents, related press-releases, TV programs, and the type of research collaborations as Appendices. (author)

  15. JAEA Takasaki annual report 2009

    International Nuclear Information System (INIS)

    Tanaka, Shigeru

    2011-01-01

    JAEA Takasaki annual report 2009 describes research and development activities performed from April 1, 2009 to March 31, 2010 with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and electron/gamma-ray irradiation facilities (an electron accelerator and three 60 Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) space, nuclear and energy engineering, 2) environmental conservation and resource security, 3) biotechnology and medical application, and 4) advanced materials, analysis and novel technology. This annual report contains 165 reports consisting of 157 research papers and 8 status reports on operation/maintenance of the irradiation facilities described above, and a list of publications, patents, related press-releases, TV programs, and the type of research collaborations as Appendices. (author)

  16. JAEA Takasaki annual report 2014

    International Nuclear Information System (INIS)

    Yokota, Wataru

    2016-02-01

    JAEA Takasaki annual report 2014 describes research and development activities performed from April 1, 2014 to March 31, 2015 mainly with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and electron/gamma-ray irradiation facilities (an electron accelerator and three 60 Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) Space, Nuclear and Energy Engineering, 2) Environmental Conservation and Resource Exploitation, 3) Medical and Biotechnological Application, and 4) Advanced Materials, Analysis and Novel Technology. This annual report contains 162 reports consisting of 154 research papers and 8 status reports on operation/maintenance of the irradiation facilities described above, a list of publications, patents, related press-releases, television broadcasting, and the type of research collaborations as appendices. (author)

  17. JAEA Takasaki annual report 2007

    International Nuclear Information System (INIS)

    Tanaka, Shigeru

    2008-11-01

    JAEA Takasaki annual report 2007 describes research and development activities performed from April 1, 2007 to March 31, 2008 with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and electron/gamma-ray irradiation facilities (an electron accelerator and three 60 Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) space, nuclear and energy engineering, 2) environment conservation and resource security, 3) biotechnology and medical application, and 4) advanced materials, analysis and novel technology. This annual report contains 174 reports consisting of 166 research papers and 8 status reports on operation/maintenance of the irradiation facilities described above, and a list of publications, related press-releases, TV programs, patents, and the type of research collaborations as Appendices. (author)

  18. JAEA Takasaki annual report 2011

    Energy Technology Data Exchange (ETDEWEB)

    Kojima, Takuji [Japan Atomic Energy Agency, Takasaki Advanced Radiation Research Institute, Takasaki, Gunma (Japan)

    2013-01-15

    JAEA Takasaki annual report 2011 describes research and development activities performed from April 1, 2011 to March 31, 2012 with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and electron/gamma-ray irradiation facilities (an electron accelerator and three {sup 60}Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) Space, Nuclear and Energy Engineering, 2) Environmental Conservation and Resource Exploitation, 3) Medical and Biotechnological Application, and 4) Advanced Materials, Analysis and Novel Technology for Facilities. This annual report contains 158 reports consisting of 150 research papers and 8 status reports on operation/maintenance of the irradiation facilities described above, and a list of publications, patents, related press-releases, television broadcasting, and the type of research collaborations as appendices. (author)

  19. JAEA Takasaki annual report 2008

    International Nuclear Information System (INIS)

    Tanaka, Shigeru

    2009-12-01

    JAEA Takasaki annual report 2008 describes research and development activities performed from April 1, 2008 to March 31, 2009 with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and electron/gamma-ray irradiation facilities (an electron accelerator and three 60 Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) space, nuclear and energy engineering, 2) environmental conservation and resource security, 3) biotechnology and medical application, and 4) advanced materials, analysis and novel technology. This annual report contains 161 reports consisting of 153 research papers and 8 status reports on operation/maintenance of the irradiation facilities described above, and a list of publications, related press-releases, TV programs, patents, and the type of research collaborations as Appendices. (author)

  20. JAEA Takasaki annual report 2012

    Energy Technology Data Exchange (ETDEWEB)

    Kojima, Takuji [Japan Atomic Energy Agency, Takasaki Advanced Radiation Research Institute, Takasaki, Gunma (Japan)

    2014-03-15

    JAEA Takasaki annual report 2012 describes research and development activities performed from April 1, 2012 to March 31, 2013 mainly with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and electron/gamma-ray irradiation facilities (an electron accelerator and three {sup 60}Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) Space, Nuclear and Energy Engineering, 2) Environmental Conservation and Resource Exploitation, 3) Medical and Biotechnological Application, and 4) Advanced Materials, Analysis and Novel Technology. This annual report contains 164 reports consisting of 156 research papers and 8 status reports on operation/maintenance of the irradiation facilities described above, a list of publications, patents, related press-releases, television broadcasting, and the type of research collaborations as appendices. (author)

  1. JAEA Takasaki annual report 2010

    Energy Technology Data Exchange (ETDEWEB)

    Kojima, Takuji [Japan Atomic Energy Agency, Takasaki Advanced Radiation Research Inst., Takasaki, Gunma (Japan)

    2012-01-15

    JAEA Takasaki annual report 2010 describes research and development activities performed from April 1, 2010 to March 31, 2011 with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and electron/gamma-ray irradiation facilities (an electron accelerator and three {sup 60}Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) Space, Nuclear and Energy Engineering, 2) Environmental Conservation and Resource Exploitation, 3) Medical and Biotechnological Application, and 4) Advanced Materials, Analysis and Novel Technology. This annual report contains 159 reports consisting of 151 research papers and 8 status reports on operation/maintenance of the irradiation facilities described above, and a list of publications, patents, related press-releases, television broadcasting, and the type of research collaborations as Appendices. (author)

  2. JAEA Takasaki annual report 2013

    International Nuclear Information System (INIS)

    Kojima, Takuji

    2015-03-01

    JAEA Takasaki annual report 2013 describes research and development activities performed from April 1, 2013 to March 31, 2014 mainly with Takasaki Ion Accelerators for Advanced Radiation Application (TIARA, four ion accelerators), and electron/gamma-ray irradiation facilities (an electron accelerator and three 60 Co gamma-ray irradiation facilities) at Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA Takasaki). These activities are classified into four research fields: 1) Space, Nuclear and Energy Engineering, 2) Environmental Conservation and Resource Exploitation, 3) Medical and Biotechnological Application, and 4) Advanced Materials, Analysis and Novel Technology. This annual report contains 169 reports consisting of 160 research papers and 9 status reports on operation/maintenance of the irradiation facilities described above, a list of publications, patents, related press-releases, television broadcasting, and the type of research collaborations as appendices. (author)

  3. DC Brushless Motor Control Design and Preliminary Testing for Independent 4-Wheel Drive Rev-11 Robotic Platform

    Directory of Open Access Journals (Sweden)

    Roni Permana Saputra

    2012-03-01

    Full Text Available This paper discusses the design of control system for brushless DC motor using microcontroller ATMega 16 that will be applied to an independent 4-wheel drive Mobile Robot LIPI version 2 (REV-11. The control system consists of two parts which are brushless DC motor control module and supervisory control module that coordinates the desired command to the motor control module. To control the REV-11 platform, supervisory control transmit the reference data of speed and direction of motor to control the speed and direction of each actuator on the platform REV-11. From the test results it is concluded that the designed control system work properly to coordinate and control the speed and direction of motion of the actuator motor REV-11 platform. 

  4. The Annual Condition of Education Report 2012

    Science.gov (United States)

    Iowa Department of Education, 2013

    2013-01-01

    The Annual Condition of Education Report provides a wide range of state-level data, including shifts in student populations and demographics, teacher salaries and characteristics, student achievement results, and school financial information. The report provides important metrics to the education community about the status of the education system.…

  5. New Mexico Charter Schools Annual Report

    Science.gov (United States)

    New Mexico Public Education Department, 2013

    2013-01-01

    In 2011, the New Mexico legislature passed changes to the Charter School Act that provided more accountability for both charters and authorizers in New Mexico. As part of that law, the Public Education Department (PED) is asked to submit an annual report on the status of charter schools in New Mexico. This is the first report submitted under that…

  6. 2011 ANNUAL SITE ENVIRONMENTAL REPORT

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, A.; Eddy, T.; Jannik, T.; Terry, B.; Cauthen, K.; Coward, L.; Dunaway-Ackerman, J.; Wilson, M.; Hutchison, J.; O' Quinn, S.

    2012-10-01

    The Savannah River Site Environmental Report for 2011 (SRNS-STI-2012-00200) is prepared for the U.S. Department of Energy (DOE) according to requirements of DOE Order 231.1 B, “Environment, Safety and Health Reporting." The annual SRS Environmental Report has been produced for more than 50 years. Several hundred copies are and interested individuals. The report’s purpose is to: present summary environmental data that characterize site environmental management performance; describe compliance status with respect to environmental standards and requirements; highlight significant programs and efforts.

  7. 1999 Annual report

    International Nuclear Information System (INIS)

    2000-01-01

    Cypress Energy Inc has grown in less than four years from a start-up oil and gas company to a significant intermediate-sized player with a 1999 exit production rate of over 10,000 barrels of oil equivalent per day, by executing a strategy of focused exploration, strategic acquisitions and controlled exploitation. In 1999, the company acquired Canadian Conquest Exploration for $ 75.4 million. providing Cypress with two new core producing areas, and completed the acquisition of Gardiner Exploration for a net consideration of $ 8.3 million, adding another new core area to the company's expanding portfolio. Oil and natural gas liquid production amounted to 3,090 bbls/day; that of natural gas to 51,669 MMcf/day. Proven and probable reserves are at 12,963 million barrels of oil and natural gas liquids; natural gas reserves stand at 225,187 MMcf. The company has undeveloped land of 468,625 acres. Gross production revenue was $78.17 million, up 129 per cent over 1998; cash flow from operations was $ 40.9 million, an increase of 134 per cent over the previous year. Net income was 20 cents per share, fully diluted, up from 6 cents in 1998. The annual report includes a review of operations, an audited statement of the company's finances, management's discussion and analysis of operations and financial status, and supporting documentation

  8. 1999 annual report

    International Nuclear Information System (INIS)

    2000-01-01

    Seventh Energy Ltd is a junior oil and gas exploration company based in Calgary, Alberta. The company's focus is in southern Alberta, with oil producing properties at Hays and Enchant, and a new gas property at Princess due to come on stream in 2000. Production decreased 26 per cent in 1999 from an average of 599 barrels of oil equivalent per day to 441 barrels of oil equivalent per day, mainly as a result of asset sales. Nevertheless, improved commodity prices increased funds from operations by 110 per cent from $751,000 to $1,577,000. The company faced serious difficulties during 1999, including high debt levels, high overhead expenses, a lack of capital to maintain the production base, a dwindling land base due to asset sales and lease expirations, and a reduced production base due to asset sales. Although some of these challenges carry over into the year 2000, the company managed to reduce its debt very significantly. With a capital budget of $4,100,000 for 2000, it expects to carry on a vigorous exploration program. The annual report explains the company's efforts during 1999 to liquidate its debt load, reviews activities in exploration and production, and provides a detailed analysis of the company's financial status, and future plans

  9. Horns Rev offshore wind farm. Environmental impact assessment of sea bottom and marine biology

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.

    2000-03-15

    An Environmental Impact Assessment (EIA) of a planned 150 MW offshore wind farm at Horns Rev has been carried out for the marine biology and sea bottom in the area, and includes vegetation and benthic fauna. The study forms part of a total EIA of the planned offshore wind farm. This EIA study has been drawn up in accordance with the guidelines laid down by the Ministry of Environment and Energy in the publication, 'Guidelines for preparation of EIAstudies for offshore wind farms. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. The area designated for the wind farm lies directly south of Horns Rev and is dominated by sand with a median particle size of 0.3 mm. Along the edges, towards areas of greater depth, the particle size increases. There are areas of fine sand in the deepest area, and in isolated pockets within the proposed wind farm site. The sediment is characterised by a very low (<1%) organic matter content. On the basis of the expected impact from the establishment of the wind farm, it is not deemed necessary to carry out special programmes during the construction phase for monitoring of the environmental-biological conditions. A monitoring and control programme is recommended during the production phase in order to follow the copper concentration in bivalves, or alternatively to initiate recovery or elimination of the copper-laden waste. A control programme is recommended during the production phase in order to follow the establishment and succession of the fouling community on the wind turbine foundations and scour-protecting revetments. (BA)

  10. Horns Rev offshore wind farm. Environmental impact assessment of sea bottom and marine biology

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S B

    2000-03-15

    An Environmental Impact Assessment (EIA) of a planned 150 MW offshore wind farm at Horns Rev has been carried out for the marine biology and sea bottom in the area, and includes vegetation and benthic fauna. The study forms part of a total EIA of the planned offshore wind farm. This EIA study has been drawn up in accordance with the guidelines laid down by the Ministry of Environment and Energy in the publication, 'Guidelines for preparation of EIAstudies for offshore wind farms. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. The area designated for the wind farm lies directly south of Horns Rev and is dominated by sand with a median particle size of 0.3 mm. Along the edges, towards areas of greater depth, the particle size increases. There are areas of fine sand in the deepest area, and in isolated pockets within the proposed wind farm site. The sediment is characterised by a very low (<1%) organic matter content. On the basis of the expected impact from the establishment of the wind farm, it is not deemed necessary to carry out special programmes during the construction phase for monitoring of the environmental-biological conditions. A monitoring and control programme is recommended during the production phase in order to follow the copper concentration in bivalves, or alternatively to initiate recovery or elimination of the copper-laden waste. A control programme is recommended during the production phase in order to follow the establishment and succession of the fouling community on the wind turbine foundations and scour-protecting revetments. (BA)

  11. Pilot power based rate control in CDMA 2000 1x EV-DO Rev-A

    Institute of Scientific and Technical Information of China (English)

    LIU Xiao-feng; GU Jian; YANG Hong-wen

    2008-01-01

    This article proposes a new algorithm to improvethe rate control efficiency of enhanced reverse link mediumaccess control (RLMAC) in the code division multiple access(CDMA) lx EV-DO release A(Rev. A) system. The newalgorithm brings reverse access terminal (AT) pilot power tothe RLMAC rate control procedure and makes it easier for alow pilot power user to increase its data rate when the systemis slightly loaded and harder to decrease its date rate when thesystem is heavily loaded. Numerical results of system levelsimulations show that the new algorithm can bring highersystem throughput, lower AT transmission power, and lowersystem load.

  12. Simulaton of the Avedøreværket Unit 1 Cogeneration Plant with DNA

    DEFF Research Database (Denmark)

    Elmegaard, Brian; Houbak, Niels

    2003-01-01

    The simulator contest proposed for the ECOS 2003 conference has been solved using the DNA energy system simulator. The contest concerns the steam process of the Avedøreværket Unit 1 (AVV1) power plant. The plant is a 250 MWCHP plant with a maximum district heat production of 330 MJ/s. The plant has...... a net electric efficiency of 42% and a maximum energy utilization of 92%. In this paper it is demonstrated, that the DNA model of AVV1 can calculate the whole flow sheet balance at any load point, i.e., any possible combination of power production and district heat production. The paper also contains...

  13. A novel, mouse mammary tumor virus encoded protein with Rev-like properties

    International Nuclear Information System (INIS)

    Indik, Stanislav; Guenzburg, Walter H.; Salmons, Brian; Rouault, Francoise

    2005-01-01

    We have identified a novel, multiple spliced, subgenomic mRNA species in MMTV producing cells of different origin containing an open reading frame encoding a 39-kDa Rev-like protein, Rem (regulator of expression of MMTV). An EGFP-Rem fusion protein is shown to be predominantly in the nucleolus. Further leptomycin B inhibits the nuclear export of nonspliced MMTV transcripts, implicating Rem in nuclear export by the Crm1 pathway in MMTV. Rem is thus reminiscent of the Rec protein from the related endogenous human retrovirus, HERV-K

  14. Permeability computation on a REV with an immersed finite element method

    International Nuclear Information System (INIS)

    Laure, P.; Puaux, G.; Silva, L.; Vincent, M.

    2011-01-01

    An efficient method to compute permeability of fibrous media is presented. An immersed domain approach is used to represent the porous material at its microscopic scale and the flow motion is computed with a stabilized mixed finite element method. Therefore the Stokes equation is solved on the whole domain (including solid part) using a penalty method. The accuracy is controlled by refining the mesh around the solid-fluid interface defined by a level set function. Using homogenisation techniques, the permeability of a representative elementary volume (REV) is computed. The computed permeabilities of regular fibre packings are compared to classical analytical relations found in the bibliography.

  15. Fundamental study on REV based on crack tensor at the Mizunami Underground Research Laboratory

    International Nuclear Information System (INIS)

    Tanno, Takeo; Sato, Toshinori; Sanada, Hiroyuki; Hikima, Ryoichi; Kumasaka, Hiroo; Tada, Hiroyuki

    2013-01-01

    The crack tensor model which is a kind of equivalent continuum model has been studied in rock mechanical investigation in the MIU. The fractured rock mass is modeled as the elastic continuum model with this crack tensor. In this study, this crack tensor based on the geological observation in the MIU project was calculated, and Representative Elementary Volume (REV) in the ventilation shaft and -300 m access/research gallery was studied based on the relative error of this crack tensor. As a result, the convergence of the relative error was faster in the -300 m access/research gallery than in the ventilation shaft. (author)

  16. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (81st, Baltimore, Maryland, August 5-8, 1998). Commission on the Status of Women.

    Science.gov (United States)

    Association for Education in Journalism and Mass Communication.

    The Commission on the Status of Women section of the Proceedings contains the following 12 papers: "Framing Women's Health with a Sense-making Approach: Magazine Coverage of Breast Cancer and Implants" (Julie L. Andsager and Angela Powers); "Gender Roles in 'Rumplestiltskin': The Effect of Fantasy Portrayals on Real-Life…

  17. Effects of Mitigation Measures on Productivity of the White Sturgeon Populations in the Columbia River Downstream from McNary Dam, and Status and Habitat Requirements of White Sturgeon Populations in the Columbia and Snake Rivers Upstream from McNary Dam, 1992-1993 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Beamesdorfer, Raymond C.; Nigro, Anthony A. (Oregon Department of Fish and Wildlife, Portland, OR)

    1993-12-01

    We report on our progress from April 1992-March 1993 in research on white sturgeon in the lower Columbia River. The study began in July 1986 and progress through 1992 was summarized in a comprehensive report in 2 volumes (Beamesderfer and Nigro 1993a, 1993b). This report details activities during the first year of Phase II of this sturgeon research. In Phase I, we assessed the status and habitat requirements of the white sturgeon populations in the Columbia River downstream from McNary Dam. Phase II will examine the effects on white sturgeon productivity of mitigative measures recommended in Phase I. The status and habitat requirements of white sturgeon populations upstream from McNary Dam will also be examined in Phase II. The study is a cooperative effort by the Oregon Department of Fish and Wildlife, Washington Department of Fisheries, U.S. Fish and Wildlife Service, and National Marine Fisheries Service. Work during the past year has focused on: (1) analysis of results of limited sampling conducted in 1992, (2) submission of Phase I results to the peer-review literature to ensure widespread dissemination, clarity of presentation, and credibility of findings, and (3) preparations for additional field work in 1993. In report sections A to D, each agency reports 1992 results if applicable and the current status of manuscripts. Results of field work conducted in 1993 will be reported in the 1994 annual report.

  18. High amplitude phase resetting in rev-erbalpha/per1 double mutant mice.

    Directory of Open Access Journals (Sweden)

    Corinne Jud

    Full Text Available Over time, organisms developed various strategies to adapt to their environment. Circadian clocks are thought to have evolved to adjust to the predictable rhythms of the light-dark cycle caused by the rotation of the Earth around its own axis. The rhythms these clocks generate persist even in the absence of environmental cues with a period of about 24 hours. To tick in time, they continuously synchronize themselves to the prevailing photoperiod by appropriate phase shifts. In this study, we disrupted two molecular components of the mammalian circadian oscillator, Rev-Erbalpha and Period1 (Per1. We found that mice lacking these genes displayed robust circadian rhythms with significantly shorter periods under constant darkness conditions. Strikingly, they showed high amplitude resetting in response to a brief light pulse at the end of their subjective night phase, which is rare in mammals. Surprisingly, Cry1, a clock component not inducible by light in mammals, became slightly inducible in these mice. Taken together, Rev-Erbalpha and Per1 may be part of a mechanism preventing drastic phase shifts in mammals.

  19. Validation of CATHENA MOD-3.5/Rev0 for single-phase water hammer

    International Nuclear Information System (INIS)

    Beuthe, T.G.

    2000-01-01

    This paper describes work performed to validate the system thermalhydraulics code CATHENA MOD-3.5c/Rev0 for single-phase water hammer. Simulations were performed and are compared quantitatively against numerical tests and experimental results from the Seven Sisters Water Hammer Facility to demonstrate CATHENA can predict the creation and propagation of pressure waves when valves are opened and closed. Simulations were also performed to show CATHENA can model the behaviour of reflected and transmitted pressure waves at area changes, dead ends, tanks, boundary conditions, and orifices in simple and more complex piping systems. The CATHENA results are shown to calculate pressure and wave propagation speeds to within 0.2% and 0.5% respectively for numerical tests and within 3.3% and 5% for experimental results respectively. These results are used to help validate CATHENA for use in single-phase water hammer analysis. They also provide assurance that the fundamental parameters needed to successfully model more complex forms of water hammer are accounted for in the MOD-3.5c/Rev0 version of CATHENA, and represent the first step in the process to validate the code for use in modelling two-phase water hammer and condensation-induced water hammer. (author)

  20. Technical reports retrieval system(rev. 1) in the field of nuclear energy

    International Nuclear Information System (INIS)

    Choi, S.D.; Lee, Y.K.; Yim, S.H.

    1983-01-01

    TRRS(rev. 1), on-line Technical Reports Retrieval System, a set of computer programs, was designed and developed to provide fast and efficient access to computer-based information files. This system was foucused upon its application to the retrival of technical reports collected in KAERI, and developed not only to meet the requirements of researchers sitting at terminal but to accomodate its sufficiently general logic to other computer systems. The retrival program language is FORTRAN IV Plus. The users can search the whole files using next eleven TRRS(rev. 1) commands, HELP, SEARCH, LOOK, COMBINE, EXPAND, SELECT, REVIEW, RESTART, TYPE, PRINT, and END. The special features of this system are as follows. First, the SEARCH command can process full and truncation (truncation mark is %), and can combine such truncated terms using Boolean operators, and (*), and and-not (.). Second, COMBINE command can combine set numbers with year(s), language(s) and a substring of titles. Third, after EXPAND command, either full or truncated term, SELECT command brings same result of SEARCH command. Finally, real time response is very short, real time response is very short, usually within a second or less. (Author)

  1. Benchmark test of JENDL-3T and -3T/Rev.1

    International Nuclear Information System (INIS)

    Takano, Hideki; Kaneko, Kunio.

    1989-10-01

    The fast reactor 70-group constant set JFS-3-J3T has been generated by using the JENDL-3T nuclear data. One-dimensional 21-benchmark cores and the ZPPR-9 core were analysed with the JFS-3-J3T set. The results obtained are summarized as follows: (1) The values of keff are underestimated by 0.6% for Pu-fueled cores and overestimated by 2% for U-fueled cores. (2) The central reaction rate ratio 239 σ f φ/ 235 σ f φ is in a good agreement with the experimental value, though 238 σ c φ/ 239 σ f φ and 238 σ f φ/ 235 σ f φ are overestimated. (3) Doppler and Na-void reactivities are in a good agreement with the measured data. (4) The prediction accuracy of radial reaction rate distributions are improved in the comparison of the results obtained with the JENDL-2 data. Furthermore, the benchmark test of JENDL-3T/Rev. 1 which was revised from JENDL-3T for several important nuclides has been again performed. It was shown that JENDL-3T/Rev. 1 would predict nuclear characteristics more satisfactorily than JENDL-3T. (author)

  2. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta.

    Directory of Open Access Journals (Sweden)

    Keith I Pardee

    2009-02-01

    Full Text Available Heme is a ligand for the human nuclear receptors (NR REV-ERBalpha and REV-ERBbeta, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription repression mediated by heme-bound REV-ERBs is reversed by the addition of nitric oxide (NO, and that the heme and NO effects are mediated by the C-terminal ligand-binding domain (LBD. A 1.9 A crystal structure of the REV-ERBbeta LBD, in complex with the oxidized Fe(III form of heme, shows that heme binds in a prototypical NR ligand-binding pocket, where the heme iron is coordinately bound by histidine 568 and cysteine 384. Under reducing conditions, spectroscopic studies of the heme-REV-ERBbeta complex reveal that the Fe(II form of the LBD transitions between penta-coordinated and hexa-coordinated structural states, neither of which possess the Cys384 bond observed in the oxidized state. In addition, the Fe(II LBD is also able to bind either NO or CO, revealing a total of at least six structural states of the protein. The binding of known co-repressors is shown to be highly dependent upon these various liganded states. REV-ERBs are thus highly dynamic receptors that are responsive not only to heme, but also to redox and gas. Taken together, these findings suggest new mechanisms for the systemic coordination of molecular clocks and metabolism. They also raise the possibility for gas-based therapies for the many disorders associated with REV-ERB biological functions.

  3. The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ

    Science.gov (United States)

    Pardee, Keith I; Xu, Xiaohui; Reinking, Jeff; Schuetz, Anja; Dong, Aiping; Liu, Suya; Zhang, Rongguang; Tiefenbach, Jens; Lajoie, Gilles; Plotnikov, Alexander N; Botchkarev, Alexey; Krause, Henry M; Edwards, Aled

    2009-01-01

    Heme is a ligand for the human nuclear receptors (NR) REV-ERBα and REV-ERBβ, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription repression mediated by heme-bound REV-ERBs is reversed by the addition of nitric oxide (NO), and that the heme and NO effects are mediated by the C-terminal ligand-binding domain (LBD). A 1.9 Å crystal structure of the REV-ERBβ LBD, in complex with the oxidized Fe(III) form of heme, shows that heme binds in a prototypical NR ligand-binding pocket, where the heme iron is coordinately bound by histidine 568 and cysteine 384. Under reducing conditions, spectroscopic studies of the heme-REV-ERBβ complex reveal that the Fe(II) form of the LBD transitions between penta-coordinated and hexa-coordinated structural states, neither of which possess the Cys384 bond observed in the oxidized state. In addition, the Fe(II) LBD is also able to bind either NO or CO, revealing a total of at least six structural states of the protein. The binding of known co-repressors is shown to be highly dependent upon these various liganded states. REV-ERBs are thus highly dynamic receptors that are responsive not only to heme, but also to redox and gas. Taken together, these findings suggest new mechanisms for the systemic coordination of molecular clocks and metabolism. They also raise the possibility for gas-based therapies for the many disorders associated with REV-ERB biological functions. PMID:19243223

  4. REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American.

    Science.gov (United States)

    Garaulet, Marta; Smith, Caren E; Gomez-Abellán, Purificación; Ordovás-Montañés, María; Lee, Yu-Chi; Parnell, Laurence D; Arnett, Donna K; Ordovás, José M

    2014-04-01

    Despite the solid connection between REV-ERB and obesity, the information about whether genetic variations at this locus may be associated with obesity traits is scarce. Therefore our objective was to study the association between REV-ERB-ALPHA1 rs2314339 and obesity in two independent populations. Participants were 2214 subjects from Spanish Mediterranean (n = 1404) and North American (n = 810) populations. Anthropometric, biochemical, dietary, and genotype analyses were performed. We found novel associations between the REV-ERB-ALPHA1 rs2314339 genotype and obesity in two independent populations: in Spanish Mediterranean and North American groups, the frequency of the minor-allele-carriers (AA+ AG) was significantly lower in the "abdominally obese" group than in those of the "nonabdominally obese" group (p obesity than noncarriers, and the effect was of similar magnitude for both populations (OR ≈ 1.50). There were consistent associations between REV-ERB-ALPHA1 genotype and obesity-related traits (p obesity was also detected in the Mediterranean population. This new discovery highlights the importance of REV-ERB-ALPHA1 in obesity and provides evidence for the connection between our biological clock and obesity-related traits. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Annual report 2003

    International Nuclear Information System (INIS)

    2004-01-01

    The Annual Report reviews the results of the Agency's programme according to the three 'pillars' of technology, safety and verification. The main part of the report, starting on page 9, generally follows the programme structure as it applied in 2003. The introductory chapter, seeks to provide a thematic analysis, based on the three pillars, of the Agency's activities within the overall context of notable developments during the year. Additional information on specific issues can be found in the latest editions of the Agency's Nuclear Safety Review, Nuclear Technology Review and Technical Co-operation Report. This material is also available on the Agency's WorldAtom web site (http://www.iaea.org/Worldatom/Documents/Anrep/Anrep2003/). All sums of money are expressed in United States dollars. The designations employed and the presentation of material in this document do not imply the expression of any opinion whatsoever on the part of the Secretariat concerning the legal status of any country or territory or of its authorities, or concerning the delimitation of its frontiers. The topics covered in the chapter related to Technology are: Nuclear Power; Nuclear Fuel Cycle and Material Technologies; Analysis for Sustainable Energy Development; Nuclear Science; Food and Agriculture; Human Health; Water Resources; Protection of the Marine and Terrestrial Environments; Physical and Chemical Applications. Topics related to safety discussed in this report are: Safety of Nuclear Installations; Radiation Safety; Management of Radioactive Waste; Security of Material. Topics related to Verification are Safeguards and Verification in Iraq Pursuant to UNSC Resolutions. A separate chapter is devoted to Management of Technical Cooperation for Development

  6. Annual report 2005

    International Nuclear Information System (INIS)

    2006-01-01

    The Annual Report reviews the results of the Agency's programme according to the three 'pillars' of technology, safety and verification. The main part of the report, starting on page 13, generally follows the programme structure as it applied in 2005. The introductory chapter, 'The Year in Review', seeks to provide a thematic analysis, based on the three pillars, of the Agency's activities within the overall context of notable developments during the year. Information on specific issues can be found in the latest editions of the Agency's Nuclear Safety Review, Nuclear Technology Review and Technical Cooperation Report. For the convenience of readers, these documents are available on the CD-ROM attached to the inside back cover of this report. Additional information covering various aspects of the Agency's programme is also provided on the attached CD-ROM, and is also available on the Agency?s iaea.org web site (http://www.iaea.org/Worldatom/Documents/Anrep/Anrep2005/). All sums of money are expressed in United States dollars. The designations employed and the presentation of material in this document do not imply the expression of any opinion whatsoever on the part of the Secretariat concerning the legal status of any country or territory or of its authorities, or concerning the delimitation of its frontiers. The topics covered in the chapter related to Technology are: Nuclear Power; Nuclear Fuel Cycle and Materials Technologies; Capacity Building and Nuclear Knowledge Maintenance for Sustainable Energy Development; Nuclear Science; Food and Agriculture; Human Health; Water Resources; Protection of the Marine and Terrestrial Environment; Physical and Chemical Applications. Topics related to Safety and Security discussed in this report are: Safety of Nuclear Installations; Radiation and Transport Safety; Management of Radioactive Waste; Nuclear Security. Topics related to Verification are Safeguards and Verification in Iraq Pursuant to UNSC Resolutions. A separate

  7. Annual report 2003

    International Nuclear Information System (INIS)

    2004-01-01

    The Annual Report reviews the results of the Agency's programme according to the three 'pillars' of technology, safety and verification. The main part of the report, starting on page 9, generally follows the programme structure as it applied in 2003. The introductory chapter, seeks to provide a thematic analysis, based on the three pillars, of the Agency's activities within the overall context of notable developments during the year. Additional information on specific issues can be found in the latest editions of the Agency's Nuclear Safety Review, Nuclear Technology Review and Technical Co-operation Report. This material is also available on the Agency's WorldAtom web site http://www.iaea.org/Worldatom/Documents/Anrep/Anrep2003/). All sums of money are expressed in United States dollars. The designations employed and the presentation of material in this document do not imply the expression of any opinion whatsoever on the part of the Secretariat concerning the legal status of any country or territory or of its authorities, or concerning the delimitation of its frontiers. The topics covered in the chapter related to Technology are: Nuclear Power; Nuclear Fuel Cycle and Material Technologies; Analysis for Sustainable Energy Development; Nuclear Science; Food and Agriculture; Human Health; Water Resources; Protection of the Marine and Terrestrial Environments; Physical and Chemical Applications. Topics related to safety discussed in this report are: Safety of Nuclear Installations; Radiation Safety; Management of Radioactive Waste; Security of Material. Topics related to Verification are Safeguards and Verification in Iraq Pursuant to UNSC Resolutions. A separate chapter is devoted to Management of Technical Cooperation for Development

  8. Annual report 1973

    International Nuclear Information System (INIS)

    1973-01-01

    The GKSS scientific annual report summarizes the problems and results of the research and development projects of 1973. In contrast to earlier annual reports, a comprehensive description of the research facilities is not included. The annual report was extended by the paragraph 'Financial Report 1973' in the chapter 'Development of Geesthacht Research Centre'. The financial report gives a survey of the financial transactions and the major operations of the year under review. (orig./AK) [de

  9. NUKEM annual report 1981

    International Nuclear Information System (INIS)

    The annual report of this important undertaking in the German nuclear industry informs about its structure, holdings and activities in 1981. The report of the management is followed by remarks on the annual statement of accounts (annual balance, profit-loss accounting) and the report of the Supervisory Board. In the annex the annual balance of NUKEM GmbH/HOBEG mbH as per December 31, 1981, and the profit-loss accounting of NUKEM GmbH/HOBEG mbH for the business year 1981 are presented. (UA) [de

  10. Annual Statistical Supplement, 2002

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2002 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  11. Annual Statistical Supplement, 2010

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2010 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  12. Annual Statistical Supplement, 2007

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2007 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  13. Annual Statistical Supplement, 2001

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2001 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  14. Annual Statistical Supplement, 2016

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2016 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  15. Annual Statistical Supplement, 2011

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2011 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  16. Annual Statistical Supplement, 2005

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2005 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  17. Annual Statistical Supplement, 2015

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2015 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  18. Annual Statistical Supplement, 2003

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2003 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  19. Annual Statistical Supplement, 2017

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2017 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  20. Annual Statistical Supplement, 2008

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2008 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  1. Annual Statistical Supplement, 2014

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2014 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  2. Annual Statistical Supplement, 2004

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2004 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  3. Annual Statistical Supplement, 2000

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2000 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  4. Annual Statistical Supplement, 2009

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2009 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  5. Annual Statistical Supplement, 2006

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2006 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  6. Administrative Circular No. 2 (Rev. 7) - Recruitment, appointment and possible developments regarding the contractual position of staff members

    CERN Multimedia

    2015-01-01

    Administrative Circular No. 2 (Rev. 7), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion at the Standing Concertation Committee meeting held on 17 February 2015 is available via the following link: AC No. 2 (Rev.7).   This revised circular cancels and replaces Administrative Circular No. 2 (Rev. 6), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" and dated January 2015. The circular was revised in order to implement the amendment to Article R II 1.17 of the Staff Regulations, which introduces the possibility of extending limited-duration (LD) contracts up to a maximum total duration of eight years from the previous duration of five years. The award of indefinite contracts will continue to be subject to the outcome of a competitive process. Department Head Of...

  7. Administrative Circulars Nos. 12 A and B (Rev. 1) – Education Fees

    CERN Multimedia

    HR Department

    2007-01-01

    Administrative Circulars Nos. 12 A and B (Rev. 1) – "Education Fees" are now available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp These Circulars cancel and replace Administrative Circular No.12 – "Education Grant" of April 1981. Copies will shortly be available in Departmental secretariats. Administrative Circular No. 12 A is applicable to staff members (except former "local staff"), fellows and paid associates, recruited before 1st January 2007. It may be noted that, at the initiative of the Human Resources Department, a number of important simplifications have been introduced. These cover in particular lump sum payments to compensate for accommodation, meals and journey expenses. Administrative Circular No. 12 B is applicable to staff members, fellows, scientific associates recruited as of 1st January 2007, as well as to former "local staff" recruited prior to this date. If you require any additional informa...

  8. Administrative Circulars Nos. 12 A and B (Rev. 1) – Education Fees

    CERN Multimedia

    HR Department

    2007-01-01

    Administrative Circulars Nos. 12 A and B (Rev. 1) – "Education Fees" are now available on the intranet site of the Human Resources Department: http://https://hr-docs.web.cern.ch/hr-docs/admincirc/admincirc_fr.asp These circulars cancel and replace Administrative Circular No.12 – "Education Grant" of April 1981. Copies will shortly be available in Departmental secretariats. Administrative Circular No. 12 A is applicable to staff members (except former "local staff"), fellows and paid associates, recruited before 1st January 2007. It may be noted that, at the initiative of the Human Resources Department, a number of important simplifications have been introduced. These cover, in particular, lump sum payments to compensate for accommodation, meals and journey expenses. Administrative Circular No. 12 B is applicable to staff members, fellows, scientific associates recruited as of 1st January 2007, as well as to former "local staff" recruited prior to this date. If you requi...

  9. Safeguards Summary Event List (SSEL), January 1, 1990--December 31, 1996, Vol. 2, Rev. 5

    International Nuclear Information System (INIS)

    1997-07-01

    The Safeguards Summary Event List (SSEL), Vol. 2, Rev. 5, provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC) which occurred and were reported from January 1, 1990, through December 31, 1996. Because of public interest, the Miscellaneous category includes a few events which involve either source material, byproduct material, or natural uranium which are exempt from safeguards requirements. Events are described under the categories of Bomb-related, Intrusion, Missing and/or Allegedly Stolen, Transportation-related, Tampering/Vandalism, Arson, Firearms, Radiological Sabotage, Nonradiological Sabotage, and Miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels

  10. Numerical Modelling of Large-Diameter Steel Piles at Horns Rev

    DEFF Research Database (Denmark)

    Augustesen, Anders Hust; Brødbæk, K. T.; Møller, M.

    2009-01-01

    Today large-diameter monopiles are the most common foundation type used for large offshore wind farms. This paper aims to investigate the behaviour of monopiles under monotonic loading taking the interaction between the pile and the subsoil into account. Focus is paid to a monopile used as founda......Today large-diameter monopiles are the most common foundation type used for large offshore wind farms. This paper aims to investigate the behaviour of monopiles under monotonic loading taking the interaction between the pile and the subsoil into account. Focus is paid to a monopile used...... as foundation for a wind turbine at Horns Rev located in the Danish sector of the North Sea. The outer diameter of the pile is 4 m and the subsoil at the location consists primarily of sand. The behaviour of the pile is investigated under realistic loading conditions by means of a traditional Winkler...

  11. Safeguards Summary Event List (SSEL), January 1, 1990--December 31, 1996, Vol. 2, Rev. 5

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    The Safeguards Summary Event List (SSEL), Vol. 2, Rev. 5, provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC) which occurred and were reported from January 1, 1990, through December 31, 1996. Because of public interest, the Miscellaneous category includes a few events which involve either source material, byproduct material, or natural uranium which are exempt from safeguards requirements. Events are described under the categories of Bomb-related, Intrusion, Missing and/or Allegedly Stolen, Transportation-related, Tampering/Vandalism, Arson, Firearms, Radiological Sabotage, Nonradiological Sabotage, and Miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels.

  12. Numerical modelling of powder caking at REV scale by using DEM

    Science.gov (United States)

    Guessasma, Mohamed; Silva Tavares, Homayra; Afrassiabian, Zahra; Saleh, Khashayar

    2017-06-01

    This work deals with numerical simulation of powder caking process caused by capillary condensation phenomenon. Caking consists in unwanted agglomeration of powder particles. This process is often irreversible and not easy to predict. To reproduce mechanism involved by caking phenomenon we have used the Discrete Elements Method (DEM). In the present work, we mainly focus on the role of capillary condensation and subsequent liquid bridge formation within a granular medium exposed to fluctuations of ambient relative humidity. Such bridges cause an attractive force between particles, leading to the formation of a cake with intrinsic physicochemical and mechanical properties. By considering a Representative Elementary Volume (REV), the DEM is then performed by means of a MULTICOR-3D software tacking into account the properties of the cake (degree of saturation) in order to establish relationships between the microscopic parameters and the macroscopic behaviour (tensile strength).

  13. Numerical modelling of powder caking at REV scale by using DEM

    Directory of Open Access Journals (Sweden)

    Guessasma Mohamed

    2017-01-01

    Full Text Available This work deals with numerical simulation of powder caking process caused by capillary condensation phenomenon. Caking consists in unwanted agglomeration of powder particles. This process is often irreversible and not easy to predict. To reproduce mechanism involved by caking phenomenon we have used the Discrete Elements Method (DEM. In the present work, we mainly focus on the role of capillary condensation and subsequent liquid bridge formation within a granular medium exposed to fluctuations of ambient relative humidity. Such bridges cause an attractive force between particles, leading to the formation of a cake with intrinsic physicochemical and mechanical properties. By considering a Representative Elementary Volume (REV, the DEM is then performed by means of a MULTICOR-3D software tacking into account the properties of the cake (degree of saturation in order to establish relationships between the microscopic parameters and the macroscopic behaviour (tensile strength.

  14. OPERATIONAL CIRCULAR No. 4 (REV. 1) – USE OF VEHICLES BELONGING TO OR RENTED BY CERN

    CERN Document Server

    2012-01-01

    Operational Circular No. 4 (Rev. 1) entitled “Use of vehicles belonging to or rented by CERN”, approved by the Director-general following discussion in the Standing Concertation Committee meeting of 15 February 2012, is available on the intranet site of the Human Resources Department: https://hr-docs.web.cern.ch/hr-docs/opcirc/opcirc.asp It cancels and replaces Operational Circular No. 4 entitled “Conditions for use by members of the CERN personnel of vehicles belonging to or rented by CERN” of April 2003. This new version enables, in particular, to include CERN contractors and their personnel, to harmonize the structure of the circular with other circulars and to simplify the procedures by permitting electronics forms. Department Head Office HR Department

  15. Introduction Of Wavestar Wave Energy Converters At The Danish Offshore Wind Power Plant Horns Rev 2

    DEFF Research Database (Denmark)

    Marquis, L.; Kramer, Morten; Kringelum, J.

    is to be connected to a wind turbine at the DONG Energy owned wind power plant Horns Rev 2 placed off the western coast of Denmark. The plant delivers its energy production to a transformer station owned by Energinet.dk. Energinet.dk has the obligation to ensure that power is transmitted to the Danish consumers...... with this combination. This can increase the value of the produced power from future wind/wave plants. Further potential synergies of combining wind and wave energy in the same area include increased energy production from the available area and sharing of infrastructure costs as well as O&M facilities. In a future....... If Executed the project will be the first one in the world where wind and wave power are combined at full scale. The goal of the project is to evaluate the opportunities of combining wind and wave energy production on a commercial scale and to demonstrate the reduction of energy fluctuations...

  16. Hard bottom substate monitoring Horns Rev offshore wind farm 2004. Survey report no. 1

    Energy Technology Data Exchange (ETDEWEB)

    Frederiksen, Rune

    2004-05-15

    In connection with the implementation of the monitoring programme concerning the ecological implication of the effect of the introduction of hard substrate related to the Horns Rev Wind Farm, the third survey was carried out in the period 2431 March 2004. The survey covered collection of fauna and flora samples from the scour protection and at the wind turbine towers at six turbine sites. Video recordings were planned at different sites to provide documentation, but due to poor visibility the video recordings were postponed. On request from Elsam Engineering A/S video inspections on technical installations were made at turbine '84 and 95. This report covers a short description of the methodology, sampling activities and site description. (au)

  17. Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors

    International Nuclear Information System (INIS)

    Kiss, A.; Li, L.; Gettemeier, T.; Venkatesh, L.K.

    2003-01-01

    Human immunodeficiency virus type 1 (HIV-1) Rev-mediated nuclear export of viral RNAs involves the interaction of its leucine-rich nuclear export sequence (NES) with nuclear cofactors. In yeast two-hybrid screens of a human lymph node derived cDNA expression library, we identified the human nucleoporin Nup98 as a highly specific and potent interactor of the Rev NES. Using an extensive panel of nuclear export positive and negative mutants of the functionally homologous NESs of the HIV-1 Rev, human T cell leukemia virus type 1 (HTLV-1) Rex, and equine infectious anemia virus (EIAV) Rev proteins, physiologically significant interaction of hNup98 with the various NESs was demonstrated. Missense mutations in the yeast nuclear export factor Crm1p that abrogated Rev NES interaction with the XXFG repeat-containing nucleoporin, Rab/hRIP, had minimal effects on the interaction of GLFG repeat-containing hNup98. Functional analysis of Nup98 domains required for nuclear localization demonstrated that the entire ORF was required for efficient incorporation into the nuclear envelope. A putative nuclear localization signal was identified downstream of the GLFG repeat region. Whereas overexpression of both full-length Nup98 and the amino-terminal GLFG repeat region, but not the unique carboxy-terminal region, induced significant suppression of HIV unspliced RNA export, lower levels of exogenous Nup98 expression resulted in a relatively modest increase in unspliced RNA export. These results suggest a physiological role for hNup98 in modulating Rev-dependent RNA export during HIV infection

  18. A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity.

    Science.gov (United States)

    Boons, Eline; Li, Guangdi; Vanstreels, Els; Vercruysse, Thomas; Pannecouque, Christophe; Vandamme, Anne-Mieke; Daelemans, Dirk

    2014-12-01

    The HIV Rev protein mediates the transport of partially and unspliced HIV mRNA from the nucleus to the cytoplasm. Rev multimerizes on a secondary stem-loop structure present in the viral intron-containing mRNA species and recruits the cellular karyopherin CRM1 to export viral mRNAs from the nucleus to the cytoplasm. Previously we have identified a single-domain intrabody (Nb(190)), derived from a llama heavy-chain antibody, which efficiently inhibits Rev multimerization and suppresses the production of infectious virus. We recently mapped the epitope of this nanobody and demonstrated that Rev residues K20 and Y23 are crucial for interaction while residues V16, H53 and L60 are important to a lesser extent. Here, we generated cell lines stably expressing Nb(190) and assessed the capacity of these cell lines to suppress the replication of different HIV-1 subtypes. These cells stably expressing the single-domain antibody are protected from virus-induced cytopathogenic effect even in the context of high multiplicity of infection. In addition, the replication of different subtypes of group M and one strain of group O is significantly suppressed in these cell lines. Next, we analysed the natural variations of Rev amino acids in sequence samples from HIV-1 infected patients worldwide and assessed the effect of Nb(190) on the most prevalent polymorphisms occurring at the key epitope positions (K20 and Y23) in Rev. We found that Nb(190) was able to suppress the function of these Rev variants except for the K20N mutant, which was present in only 0.7% of HIV-1 sequence populations (n = 4632). Cells stably expressing the single-domain intrabody Nb(190) are protected against virus-induced cytopathogenic effect and display a selective survival advantage upon infection. In addition, Nb(190) suppresses the replication of a wide range of different HIV-1 subtypes. Large-scale sequence analysis reveals that the Nb(190) epitope positions in Rev are well conserved across major HIV-1

  19. Administrative circular No. 2 (Rev. 5) – Recruitment, appointment and possible developments regarding the contractual position of staff members

    CERN Document Server

    HR Department

    2011-01-01

    Administrative Circular No. 2 (Rev. 5) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 1 September 2011, is available on the intranet site of the Human Resources Department: https://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 2 (Rev. 4) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" of September 2009. Department Head Office

  20. Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus

    Directory of Open Access Journals (Sweden)

    Wesselingh Steven L

    2007-07-01

    Full Text Available Abstract Background The Sydney blood bank cohort (SBBC of long-term survivors consists of multiple individuals infected with nef-deleted, attenuated strains of human immunodeficiency virus type 1 (HIV-1. Although the cohort members have experienced differing clinical courses and now comprise slow progressors (SP as well as long-term nonprogressors (LTNP, longitudinal analysis of nef/long-terminal repeat (LTR sequences demonstrated convergent nef/LTR sequence evolution in SBBC SP and LTNP. Thus, the in vivo pathogenicity of attenuated HIV-1 strains harboured by SBBC members is dictated by factors other than nef/LTR. Therefore, to determine whether defects in other viral genes contribute to attenuation of these HIV-1 strains, we characterized dominant HIV-1 rev alleles that persisted in 4 SBBC subjects; C18, C64, C98 and D36. Results The ability of Rev derived from D36 and C64 to bind the Rev responsive element (RRE in RNA binding assays was reduced by approximately 90% compared to Rev derived from HIV-1NL4-3, C18 or C98. D36 Rev also had a 50–60% reduction in ability to express Rev-dependent reporter constructs in mammalian cells. In contrast, C64 Rev had only marginally decreased Rev function despite attenuated RRE binding. In D36 and C64, attenuated RRE binding was associated with rare amino acid changes at 3 highly conserved residues; Gln to Pro at position 74 immediately N-terminal to the Rev activation domain, and Val to Leu and Ser to Pro at positions 104 and 106 at the Rev C-terminus, respectively. In D36, reduced Rev function was mapped to an unusual 13 amino acid extension at the Rev C-terminus. Conclusion These findings provide new genetic and mechanistic insights important for Rev function, and suggest that Rev function, not Rev/RRE binding may be rate limiting for HIV-1 replication. In addition, attenuated rev alleles may contribute to viral attenuation and long-term survival of HIV-1 infection in a subset of SBBC members.

  1. Analysis of translesion DNA synthesis activity of the human REV1 protein, which is a key player in radiation-induced mutagenesis

    International Nuclear Information System (INIS)

    Masuda, Yuji; Kamiya, Kenji

    2003-01-01

    Ionizing radiation frequently causes oxidative DNA damage in cells. It has been suggested that functions of the REV1 gene are induction of mutations and prevention of cell death caused by ionizing radiation through the damage bypass DNA replication. The gene product possesses a deoxycytidyl transferase activity, which is required for translesion DNA synthesis of a variety of damaged bases and an abasic site. To elucidate molecular mechanisms of the mutagenesis and translesion DNA synthesis, it is important to characterize the enzymatic properties of the REV1 protein. Here, we describe a novel method for purifying the recombinant human REV1 protein and the anzymatic properties of the protein. We established an efficient system for induction of the recombinant human REV1 protein in Escherichia coli cells. The REV1 protein was purified to homogeneity using nickel-chelating sepharose, heparin sepharose and superdex 200 chromatography. When purified by this method, REV1 protein is free of endo-, exonuclease and DNA polymerase activities. The purified REV1 protein is suitable for enzymological studies, and we used this to biochemical characterization. The REV1 protein inserts dCMP opposite templates G, A, T, C and an abasic site and inserts dGMP and dTMP opposite template G. Kinetic analysis provided evidence for high efficiency for dCMP insertion opposite template G and an abasic site, suggesting that the REV1 protein play a role in translesion DNA synthesis of an abasic site. (author)

  2. CSIR Annual report 1965

    CSIR Research Space (South Africa)

    CSIR

    1965-01-01

    Full Text Available stream_source_info Annual Report_ 1965.pdf.txt stream_content_type text/plain stream_size 48 Content-Encoding ISO-8859-1 stream_name Annual Report_ 1965.pdf.txt Content-Type text/plain; charset=ISO-8859-1 ...

  3. CSIR Annual report 1992

    CSIR Research Space (South Africa)

    CSIR

    1992-01-01

    Full Text Available stream_source_info Annual Report_ 1992.pdf.txt stream_content_type text/plain stream_size 39 Content-Encoding ISO-8859-1 stream_name Annual Report_ 1992.pdf.txt Content-Type text/plain; charset=ISO-8859-1 ...

  4. CSIR Annual report 1979

    CSIR Research Space (South Africa)

    CSIR

    1979-01-01

    Full Text Available stream_source_info CSIR Annual report_1979.pdf.txt stream_content_type text/plain stream_size 86 Content-Encoding ISO-8859-1 stream_name CSIR Annual report_1979.pdf.txt Content-Type text/plain; charset=ISO-8859-1 ...

  5. CSIR Annual report 1976

    CSIR Research Space (South Africa)

    CSIR

    1976-01-01

    Full Text Available stream_source_info Annual Report_1976.pdf.txt stream_content_type text/plain stream_size 75 Content-Encoding ISO-8859-1 stream_name Annual Report_1976.pdf.txt Content-Type text/plain; charset=ISO-8859-1 ...

  6. CSIR Annual report 1978

    CSIR Research Space (South Africa)

    CSIR

    1978-01-01

    Full Text Available stream_source_info Annual Report_1978.pdf.txt stream_content_type text/plain stream_size 78 Content-Encoding ISO-8859-1 stream_name Annual Report_1978.pdf.txt Content-Type text/plain; charset=ISO-8859-1 ...

  7. CSIR Annual report 1991

    CSIR Research Space (South Africa)

    CSIR

    1991-01-01

    Full Text Available stream_source_info Annual Report_ 1991.pdf.txt stream_content_type text/plain stream_size 40 Content-Encoding ISO-8859-1 stream_name Annual Report_ 1991.pdf.txt Content-Type text/plain; charset=ISO-8859-1 ...

  8. Annual Partnership Report, 2016

    Science.gov (United States)

    Wyoming Community College Commission, 2016

    2016-01-01

    The "Annual Partnership Report" catalogs partnerships that Wyoming community colleges established and maintained for each fiscal year. This partnership report fulfills statutory reporting requirement W.S. 21-18-202(e)(iv) which mandates the development of annual reports to the legislature on the outcomes of partnerships between colleges…

  9. Annual Report 1997

    Energy Technology Data Exchange (ETDEWEB)

    Golnik, N.; Mika, J.R.; Wieteska, K. [eds.

    1998-12-31

    This Annual Report of the Institute of Atomic Energy describes the results of the research works carried out at the Institute at 1997. As in the preceding years the authors of the individual scientific reports published in this Annual Report are fully responsible for their content and layout. The Report contains the information on other activities of the Institute as well. (author)

  10. Annual Energy Review, 2008

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-06-01

    The Annual Energy Review (AER) is the Energy Information Administration's (EIA) primary report of annual historical energy statistics. For many series, data begin with the year 1949. Included are statistics on total energy production, consumption, trade, and energy prices; overviews of petroleum, natural gas, coal, electricity, nuclear energy, renewable energy, and international energy; financial and environment indicators; and data unit conversions.

  11. Natural gas annual 1991

    International Nuclear Information System (INIS)

    1993-01-01

    The Natural Gas Annual 1991 provides information on the supply and disposition of natural gas to a wide audience including industry, consumers Federal and State agencies, and education institutions. This report, the Natural Gas Annual 1991 Supplement: Company Profiles, presents a detailed profile of selected companies

  12. Annual Report 2001

    International Nuclear Information System (INIS)

    Swiboda, G.

    2002-01-01

    This Annual Report of the Institute of Atomic Energy describes the results of the research works carried out at the Institute at 2001. As in the preceding years the authors of the individual scientific reports published in this Annual Report are fully responsible for their content and layout. The Report contains the information on other activities of the Institute as well. (author)

  13. Annual report to Congress

    International Nuclear Information System (INIS)

    1987-01-01

    This is the ninth Annual Report to Congress of the United States Department of Energy. It covers the activities of all elements of the Department except the independent Federal Regulatory Commission, which issues its own annual report. 88 refs., 43 tabs

  14. Annual Report 1997

    International Nuclear Information System (INIS)

    Golnik, N.; Mika, J.R.; Wieteska, K.

    1998-01-01

    This Annual Report of the Institute of Atomic Energy describes the results of the research works carried out at the Institute at 1997. As in the preceding years the authors of the individual scientific reports published in this Annual Report are fully responsible for their content and layout. The Report contains the information on other activities of the Institute as well. (author)

  15. Annual Report 1997

    Energy Technology Data Exchange (ETDEWEB)

    Golnik, N; Mika, J R; Wieteska, K [eds.

    1999-12-31

    This Annual Report of the Institute of Atomic Energy describes the results of the research works carried out at the Institute at 1997. As in the preceding years the authors of the individual scientific reports published in this Annual Report are fully responsible for their content and layout. The Report contains the information on other activities of the Institute as well. (author)

  16. Idaho National Laboratory PCB Annual Document Log and Annual Records Report for calendar year 2014

    Energy Technology Data Exchange (ETDEWEB)

    Layton, Deborah L. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-06-01

    The requirements for the reporting of polychlorinated biphenyl (PCB)-related activities are found in 40 Code of Federal Regulations (CFR) 761 Subpart J, "General Records and Reports." The PCB Annual Document Log is a detailed record of the PCB waste handling activities at the facility. The facility must prepare it each year by July 1 and maintain it at the facility for at least 3 years after the facility ceases using or storing PCBs and PCB items. While submittal of the PCB Annual Document Log to the U.S. Environmental Protection Agency (EPA) is not required by regulation, EPA has verbally requested in telephone conversations that this report be submitted to them on an annual basis. The Annual Records are not required to be submitted to EPA and are not considered to be part of the Annual Document Log, but are included to provide the complete disposition history or status of all PCB activities during the year. The Annual Document Log section of this report (Section 2.0) meets the requirements of 40 CFR 761.180(a)(2), as applicable, while the Annual Records section (Section 3.0) meets the requirement of 40 CFR 761.180(a)(1).

  17. JAERI TIARA annual report vol. 2 (1992)

    International Nuclear Information System (INIS)

    Ishigaki, Isao; Tanaka, Ryuichi; Nashiyama, Isamu; Naramoto, Hirosi; Omichi, Hideki; Toraishi, Akio; Watanabe, Hiromasa; Watanabe, Hiroshi

    1993-12-01

    This annual report describes research activities which have been performed with the JAERI TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities from April 1, 1992 to March 31, 1993. Summary reports of 60 papers and brief descriptions on status of TIARA in the period are contained. A list of publications, the type of research collaborations and organization of TIARA are also given as appendices. (author)

  18. Nuclear safety research project. Annual report 1995

    International Nuclear Information System (INIS)

    Hueper, R.

    1996-08-01

    The reactor safety R and D work of the Karlsruhe Research Centre (FZK) has been part of the Nuclear Safety Research Project (PSF) since 1990. The present annual report 1995 summarizes the R and D results. The research tasks are coordinated in agreement with internal and external working groups. The contributions to this report correspond to the status of early 1996. An abstract in English precedes each of them, whenever the respective article is written in German. (orig.) [de

  19. 3rd annual biomass energy systems conference

    Energy Technology Data Exchange (ETDEWEB)

    1979-10-01

    The main objectives of the 3rd Annual Biomass Energy Systems Conference were (1) to review the latest research findings in the clean fuels from biomass field, (2) to summarize the present engineering and economic status of Biomass Energy Systems, (3) to encourage interaction and information exchange among people working or interested in the field, and (4) to identify and discuss existing problems relating to ongoing research and explore opportunities for future research. Abstracts for each paper presented were edited separately. (DC)

  20. DESY annual report on scientific activities 1982

    International Nuclear Information System (INIS)

    This annual report contains a description of the organization of DESY, a list of international collaborations, short descriptions of the experiments at the storage rings PETRA and DORIS II, the muon scattering experiments at the CERN SPS, experiments with synchrotron radiation, and research in theoretical physics, descriptions of the status and developments of the accelerators and storage rings, a survey about the developments in data processing, and a list of publications and speeches. (HSI) [de

  1. Annual report 1970 - 1971 - 1972

    International Nuclear Information System (INIS)

    Freund, J.; Hildebrandt, G.; Huber, A.; Klockgether, J.; Piplies, L.; Ross, W.; Radebold, R.

    1972-12-01

    The 1st part reports on the international MHD research, the project of a liquid metal MHD system in the FRG, the task to be solved in the special research section, and the purpose of the present annual report. The 2nd part discusses the status of and advances in MHD research on an international scale as well as at the Technische Universitaet Berlin and presents a list of the papers published in the period under report, the contributions to public colloquia and other, more general activities. The 3rd part describes the structure, function, and organisation of the special research section, presents data on its personnel and financial capacity, and reports on what was learnt in organisational practice. (GG/AK) [de

  2. OPERATIONAL CIRCULAR NO2 (REV. 1) - APRIL 1998 'CONDITIONS OF ACCESS TO THE FENCED PARTS OF THE CERN SITE'

    CERN Multimedia

    Human Resources Division

    2001-01-01

    Subsidiary document 'Implementation Measures' (Rev. 2) - April 2001 The subsidiary document has been amended. Copies are available from Divisional Secretariats and at CERN card issue points. Note : Administrative and operational circulars, as well as the lists of those in force, are available for consultation on WWW : ADMINISTRATIVE CIRCULARS OPERATIONAL CIRCULARS

  3. 78 FR 27971 - Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not...

    Science.gov (United States)

    2013-05-13

    ...] Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not Withdrawn From Sale... ophthalmic solution), 0.5%, was not withdrawn from sale for reasons of safety or effectiveness. This... ophthalmic solution, 0.5%, if all other legal and regulatory requirements are met. FOR FURTHER INFORMATION...

  4. Finanšu pārskata revīzijas process lielai sabiedrībai

    OpenAIRE

    Špoģe, Sarmīte

    2018-01-01

    Finanšu pārskata revīzijas process ir svarīgs temats, jo pirmreizēji revidētiem uzņēmumiem tiek atklātas būtiskas neatbilstības grāmatvedības uzskaitē, tās atbilstībai LR likumiem un normatīvajiem aktiem, kā arī finanšu pārskata sagatavošanā. Darba mērķis: apkopot un analizēt finanšu pārskata revīzijas procesu lielā sabiedrībā, noteikt revīzijas riskus, izstrādāt priekšlikumus revīzijas procesa uzlabošanai. Izvirzīto mērķu sasniegšanai autore pētīja un apkopoja informāciju par finanšu pārska...

  5. Upper Bound Radiation Dose Assessment for Military Personnel at McMurdo Station, Antarctica, between 1962 and 1979 (2REV)

    Science.gov (United States)

    2017-09-30

    N IC A L R EP O R T Defense Threat Reduction Agency 8725 John J. Kingman Road , MS-6201 Fort Belvoir, VA 22060-6201 STANDARD FORM 298 (Rev. 8/98...8725 John J. Kingman Road , Mail Stop 6201 Fort...Early Operation ..................................................................................... 5 2.2 Operations and Maintenance

  6. Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    DEFF Research Database (Denmark)

    Fakouri, Nima Borhan; Durhuus, Jon Ambaek; Regnell, Christine Elisabeth

    2017-01-01

    (ADP) ribose polymerase 1 (PARP1) activity, low endogenous NAD+, low expression of SIRT1 and PGC1α and low adenosine monophosphate (AMP)-activated kinase (AMPK) activity. We conclude that replication stress via Rev1-deficiency contributes to metabolic stress caused by compromized mitochondrial function via...... the PARP-NAD+-SIRT1-PGC1α axis....

  7. Reliability of Concentric, Eccentric and Isometric Knee Extension and Flexion when using the REV9000 Isokinetic Dynamometer

    DEFF Research Database (Denmark)

    de Carvalho Froufe Andrade, Alberto César Pereira; Caserotti, Paolo; de Carvalho, Carlos Manuel Pereira

    2013-01-01

    The aim of this study was to assess the reliability of isokinetic and ISO knee extensor and flexor muscle strength when using the REV9000 (Technogym) isokinetic dynamometer. Moreover, the reliability of several strength imbalance indices and bilateral ratios were also examined. Twenty-four physic...

  8. A Comprehensive Experiment for Molecular Biology: Determination of Single Nucleotide Polymorphism in Human REV3 Gene Using PCR-RFLP

    Science.gov (United States)

    Zhang, Xu; Shao, Meng; Gao, Lu; Zhao, Yuanyuan; Sun, Zixuan; Zhou, Liping; Yan, Yongmin; Shao, Qixiang; Xu, Wenrong; Qian, Hui

    2017-01-01

    Laboratory exercise is helpful for medical students to understand the basic principles of molecular biology and to learn about the practical applications of molecular biology. We have designed a lab course on molecular biology about the determination of single nucleotide polymorphism (SNP) in human REV3 gene, the product of which is a subunit of…

  9. The calculational VVER burnup Credit Benchmark No.3 results with the ENDF/B-VI rev.5 (1999)

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez Gual, Maritza [Centro de Tecnologia Nuclear, La Habana (Cuba). E-mail: mrgual@ctn.isctn.edu.cu

    2000-07-01

    The purpose of this papers to present the results of CB3 phase of the VVER calculational benchmark with the recent evaluated nuclear data library ENDF/B-VI Rev.5 (1999). This results are compared with the obtained from the other participants in the calculations (Czech Republic, Finland, Hungary, Slovaquia, Spain and the United Kingdom). The phase (CB3) of the VVER calculation benchmark is similar to the Phase II-A of the OECD/NEA/INSC BUC Working Group benchmark for PWR. The cases without burnup profile (BP) were performed with the WIMS/D-4 code. The rest of the cases have been carried with DOTIII discrete ordinates code. The neutron library used was the ENDF/B-VI rev. 5 (1999). The WIMS/D-4 (69 groups) is used to collapse cross sections from the ENDF/B-VI Rev. 5 (1999) to 36 groups working library for 2-D calculations. This work also comprises the results of CB1 (obtained with ENDF/B-VI rev. 5 (1999), too) and CB3 for cases with Burnup of 30 MWd/TU and cooling time of 1 and 5 years and for case with Burnup of 40 MWd/TU and cooling time of 1 year. (author)

  10. Epitopes of human immunodeficiency virus regulatory proteins tat, nef, and rev are expressed in normal human tissue

    NARCIS (Netherlands)

    Parmentier, H. K.; van Wichen, D. F.; Meyling, F. H.; Goudsmit, J.; Schuurman, H. J.

    1992-01-01

    The expression of regulatory proteins tat, rev, and nef of human immunodeficiency virus type-1 (HIV-1) and tat of HIV-2 was studied in frozen sections of lymph nodes from HIV-1-infected individuals, and various tissues from uninfected persons. In HIV-1-positive lymph nodes, monoclonal antibodies to

  11. Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).

    Science.gov (United States)

    Vincendeau, Michelle; Kramer, Susanne; Hadian, Kamyar; Rothenaigner, Ina; Bell, Jeanne; Hauck, Stefanie M; Bickel, Christian; Nagel, Daniel; Kremmer, Elisabeth; Werner, Thomas; Leib-Mösch, Christine; Brack-Werner, Ruth

    2010-10-23

    In human astrocytes, restriction of HIV replication involves inhibition of HIV Rev activity. We previously identified a Rev-interacting human protein fragment (16.4.1) that can reduce Rev activity. The 16.4.1 sequence is contained in a group of highly similar host cell proteins, which we call the Risp family. Here we investigate whether the Risp family is connected to HIV replication in astrocytes. Cell/tissue lysates were analyzed for Risp expression by western blot with various anti-Risp antibodies. The interaction of astrocytic Risp members with Rev was investigated by affinity chromatography. Astrocytes were transfected with expression plasmids containing cDNAs encoding full-length Risp or the isolated 16.4.1 region for Risp overexpression or with siRNAs designed for Risp knock-down. Rev activity was investigated with a Rev-reporter assay. RNA levels were quantified by real-time RT-PCR, HIV Gag levels by p24ELISA. Expression of the Risp family was demonstrated in human brain tissues and astrocytes. Astrocytes were shown to produce Risp family members that interact with Rev. Production of HIV Gag proteins and Rev-dependent RNAs in persistently infected astrocytes increased upon Risp knock-down and decreased upon Risp overexpression. Risp knock-down increased Rev activity and raised proportions of Rev proteins in the nucleus of astrocytes. Our results link the Risp family to restriction of HIV production and inhibition of Rev activity in astrocytes. We conclude that the Risp family represents a novel family of host factors that can control HIV replication and may be important for the containment of HIV infection in brain reservoirs.

  12. Study on the REV Size of Fractured Rock in the Non-Darcy Flow Based on the Dual-Porosity Model

    Directory of Open Access Journals (Sweden)

    Yuan Wang

    2018-01-01

    Full Text Available For the problem of whether the representative elementary volume (REV obtained in the Darcy flow is also applicable to the case of the non-Darcy flow, the study on the REV size within the non-Darcy flow is proposed tentatively. The concept of the REV in the non-Darcy flow is based on the definition of the REV. According to the determination of the REV in the Darcy flow, the intrinsic permeability k and non-Darcy coefficient β are used simultaneously for the determination of the REV in the non-Darcy flow. The pore pressure cohesive element (PPCE is developed with the subroutine in ABAQUS. Then the simulation method of the Darcy and non-Darcy flow in the fractured rock mass is built using the PPCE. The proposed plan is examined through the comparison with existing research results. It is validated that this technic is efficient and accurate in simulating the Darcy and non-Darcy flow in the fractured rock mass. Combined with fracture networks generated by Monte Carlo Simulation technique, the PPCE is applied to the study on the REV size. Both conditions of the Darcy and non-Darcy flow are simulated for comparison. The simulation results of this model show that the REV of the non-Darcy flow is inconsistent with the REV of the Darcy flow, and the REV of the non-Darcy flow is more significant than the REV of the Darcy flow. The intrinsic permeability k tensors obtained in the Darcy flow and the non-Darcy flow are basically the same.

  13. NERI 2004 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    None

    2004-01-01

    The United States Department of Energy (DOE) created the Nuclear Energy Research Initiative (NERI) in Fiscal Year (FY) 1999 in response to recommendations provided by the President's Committee of Advisors on Science and Technology. The purpose of NERI is to sponsor research and development (R&D) in the nuclear energy sciences to address the principal barriers to the future use of nuclear energy in the United States. NERI is helping to preserve the nuclear science and engineering infrastructure within the Nation's universities, laboratories, and industry, and is advancing the development of nuclear energy technology, enabling the United States to maintain a competitive position in nuclear science and technology. Research under this initiative also addresses issues associated with the maintenance of existing U.S. nuclear plants. The NERI program is managed and funded by DOE's Office of Nuclear Energy, Science and Technology. ''The Nuclear Energy Research Initiative 2004 Annual Report'' serves to inform interested parties of progress made in NERI on a programmatic level as well as research progress made on individual NERI projects. Section 2 of this report provides background on the creation and implementation of NERI and on the focus areas for NERI research. Section 3 provides a discussion on NERI's mission, goals and objectives, and work scope. Section 4 highlights the major accomplishments of the NERI projects and provides brief summaries of the NERI research efforts that were completed in 2004. Section 5 provides a discussion on the impact NERI has had on U.S. university nuclear programs. Sections 6 through 8 provide project status reports by research area for each of the fiscal year (FY) 2001 and 2002 projects that were active in FY 2004. Research objectives, progress made over the last year, and activities planned for the next year are described for each project. Sections 9 through 11 present each of the newly awarded 2005

  14. RTE - annual report 2006

    International Nuclear Information System (INIS)

    2006-01-01

    RTE is the French electricity transmission system operator responsible for operation, maintenance and development, With a system which is the largest in Europe - 100,000 kilometres of high voltage and extra-high voltage circuits and 46 cross-border interconnections, plus a key location at the geographical hub - RTE is playing a key role in the development of the European electricity market. RTE is a public service company guaranteeing the efficient operation and reliability of the French power system, and providing equitable access to all system users. The company is part of the EDF Group, but has totally independent management and administration, as required by law. In 2005, RTE became a limited liability company with an Executive Board and Supervisory Board; this corporate status guarantees due neutrality in providing service to all players on the electricity market. RTE is the Number 1 electricity transmission system in Europe with 8,300 employees and 4 billion euros turnover. This activity report presents: 1 - Background: The RTE Transmission System, Message from the Chairman of the Executive Board; 2 - A High Performance Public Service Company at the Hub of the European Electricity Market: 2006 overview and Highlights, RTE Governance and Organisation; 3 - A Year with Many Developments: Satisfied Customers on a More Efficient Market, Reliable, Upgraded Industrial Facilities, A Commitment to Environmentally Friendly Public Service, New Foundations for Human Resources Policy, International Business on the Move, A Good Improvement in Financial Performance; 4 - Glossary; 5 - Management Report: Financial and Legal Information (Highlights in 2006, Market Trends, Business and Results for 2006, Capital, Financial Structure, Prospects for 2007, Other Financial and Legal Information), Information on the Environment (Environment Policy - Review, Respect for Natural Environments and Landscapes, Consultation and Consideration, Research, Continuing Improvement, Environmental

  15. The effects of cynodon dactylon on the immune response of NMRI-MICE after challenge with REV1

    Directory of Open Access Journals (Sweden)

    Behrooz Ilkhanizadeh

    2016-10-01

    Full Text Available Cynodon dactylon is used in Iranian traditional medicine as a healing agent for reducing the complications of diabetes mellitus. We proposed that Cynodon dactylon may perform its effects through moderating humoral and cellular immune responses. We aimed to determine the possible effects of hydroalcholic extract of Cynodon dactylonon humoral and cellular immune responses following the Rev1 challenge in the mouse model. 20 NMRI male mice were randomly grouped in two equal groups and immunized with Rev1[0.1 ml Rev1+0.9 PBS[. Mice in the treatment group orally received 400 mg/kg hydroalcoholic extract of Cynodon dactylon every day from the beginning of the study for 2 weeks. Blood samples were obtained from the animals 5 days after the last injection. Moreover, 48 hr before bleeding time, Rev1[0.1 ml Rev1+0.9 PBS[was injected into the left hind foot pad of mice. The levels of anti-Rev1 antibody and the specific cellular immune responses were measured by microhemagglutination test and footpad thickness, respectively. Moreover, susceptibility of macrophages respiratory burst and proliferation of immune cells were measured in order withNitroblue tetrazolium[NBT] and Microculture Tetrazolium Assay [MTT]. The concentrations of IL-1, TNFα, Il-6, and IL-10 in the serum were determined using commercially available ELISA kits. We found a significant increase in anti-Rev1 antibody levels and simultaneously a significant decrease in the level of cellular immunity[DTH] in the treatment group compared to the control group. Lymphocyte proliferation index in splenocytes was significantly increased in the treatment group. However, the level of respiratory burst in phagocytic population of splenocytes dramatically decreased in the treatment group compared to the control. A significant decrease in IL-6, TNF-α , IL-1 and increaseIl-10 serum levels were also seen in the treatment group. Cynodon dactylon extract could have an anti-inflammatory effect through

  16. 39 CFR 3060.22 - Financial status report.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Financial status report. 3060.22 Section 3060.22... THEORETICAL COMPETITIVE PRODUCTS ENTERPRISE § 3060.22 Financial status report. The Postal Service shall file a Financial Status Report in the form and content of Table 2, below. Table 2—Annual Summary of Competitive...

  17. Status epilepticus

    NARCIS (Netherlands)

    Hensiek, AE; Absalom, Anthony

    2006-01-01

    Status epilepticus is defined as epileptic activity that continues for more than 30 minutes as a single seizure or as recurrent seizures without inter-ictal return of consciousness. The seizure activity is usually classified as partial or generalized. Although status epilepticus is an uncommon

  18. NIRE annual report 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    The National Institute for Resources and Environment (NIRE) has a R & D concept of 'ecotechnology' that aims to protect the environment from degradation whilst promoting sustainable development. This annual report presents summaries of 32 recent research efforts.

  19. ASIST 2002 annual meeting

    CERN Multimedia

    Peek, R

    2003-01-01

    Review of discussions and presentations at the American Society for Information Science and Technology 2002 annual meeting. Topics covered included new models of scholarly publishing and the development of the semantic web (1 page).

  20. SIS - Annual Catch Limit

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Annual Catch Limit (ACL) dataset within the Species Information System (SIS) contains information and data related to management reference points and catch data.

  1. IKO Annual Report 1976

    International Nuclear Information System (INIS)

    1977-01-01

    The IKO Annual Report of 1976 relates their progress in different projects and project fields. The fields covered include electron scattering, pion and muon physics, theory, radio- and nuclear chemistry, technical department, MEA, nuclear reactions and nuclear spectroscopy

  2. Annual Adjustment Factors

    Data.gov (United States)

    Department of Housing and Urban Development — The Department of Housing and Urban Development establishes the rent adjustment factors - called Annual Adjustment Factors (AAFs) - on the basis of Consumer Price...

  3. 2002 Annual report: synthesis

    International Nuclear Information System (INIS)

    2003-01-01

    This synthesis of the Annual Report 2002 presents information of the main activities on the scope of the radiation protection and nuclear safety of the Nuclear Regulatory Authority (ARN) of the Argentina during 2002

  4. Annual report 1980

    International Nuclear Information System (INIS)

    1981-01-01

    This annual report contains a description of the named institute, the research programm, reports from the scientific establishments, a description of different cooperations, and a list of scientific publications. (HSI) [de

  5. Annual Report 1974

    International Nuclear Information System (INIS)

    1975-01-01

    This annual report supersedes the work done in the nuclear physics institute at Lyon. The studied matters are the following: nuclear theory, nuclear reactions, nuclear spectroscopy and nuclear chemistry [fr

  6. 2010 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-01-01

    This annual report includes: an overview of Western; approaches for future hydropower and transmission service; major achievements in FY 2010; FY 2010 customer Integrated Resource Planning, or IRP, survey; and financial data.

  7. Annual report 1990

    International Nuclear Information System (INIS)

    Gaeggeler, H.W.; Lorenzen, R.

    1991-04-01

    This annual report of the chemistry laboratory gives an overview of research performed during 1990 in the field of geochemistry, trace analysis, aerosol chemistry, heavy elements, cement chemistry and analytical chemistry. figs., tabs., refs

  8. Scientific annual report 1980

    International Nuclear Information System (INIS)

    1981-01-01

    This annual report contains a collection of the abstracts of the publications concerning research and development in the named institute together with a bibliography about further publications, contributions to conferences and speeches. (HSI) [de

  9. Annual report - LNLS - 1990

    International Nuclear Information System (INIS)

    1990-01-01

    This is the 1990 Annual Report of the LNLS, the upcoming Brazilian Synchrotron Light Source. It discusses its projects, organization as well as the proposed experimental stations. It presents also a list of publications. (A.C.A.S.)

  10. Annual report 2005

    International Nuclear Information System (INIS)

    Toncik, M.

    2006-04-01

    In this Annual report the operating of the Slovak Environmental Agency in 2005 is reported. The structure of the Agency, mission, personnel structure, financing, monitoring of the environment, international cooperation and coordination of research programmes are reviewed

  11. Annual report 2002

    International Nuclear Information System (INIS)

    Toncik, M.

    2003-04-01

    In this Annual report the operating of the Slovak Environmental Agency in 2002 is reported. Structure of the Agency, mission, personnel structure, financing, monitoring of the environment, international cooperation and coordination of research programmes are reviewed

  12. Annual report 2004

    International Nuclear Information System (INIS)

    Toncik, M.

    2005-04-01

    In this Annual report the operating of the Slovak Environmental Agency in 2004 is reported. The structure of the Agency, mission, personnel structure, financing, monitoring of the environment, international cooperation and coordination of research programmes are reviewed

  13. Annual report 2003

    International Nuclear Information System (INIS)

    Toncik, M.

    2004-04-01

    In this Annual report the operating of the Slovak Environmental Agency in 2003 is reported. The structure of the Agency, mission, personnel structure, financing, monitoring of the environment, international cooperation and coordination of research programmes are reviewed

  14. Annual report 2006

    International Nuclear Information System (INIS)

    Anon

    2007-04-01

    In this Annual report the operating of the Slovak Environmental Agency in 2006 is reported. The structure of the Agency, mission, personnel structure, financing, monitoring of the environment, international cooperation and coordination of research programmes are reviewed

  15. Annual Report 1978

    International Nuclear Information System (INIS)

    1979-01-01

    The annual report gives the specific scientific results in the fields of nuclear and radiation physics, radiation chemistry, radiochemistry and data processing with a list of publications. (orig.) [de

  16. 2000 Annual report: synthesis

    International Nuclear Information System (INIS)

    2001-01-01

    This synthesis of the Annual Report 2000 present information of the main activities on the scope of the radiation protection and nuclear safety of the Nuclear Regulatory Authority (NRA) of the Argentina during 2000

  17. 2001 Annual report: synthesis

    International Nuclear Information System (INIS)

    2001-01-01

    This synthesis of the Annual Report 2001 presents information of the main activities on the scope of the radiation protection and nuclear safety of the Nuclear Regulatory Authority (ARN) of the Argentina during 2001

  18. Domain- and nucleotide-specific Rev response element regulation of feline immunodeficiency virus production

    Science.gov (United States)

    Na, Hong; Huisman, Willem; Ellestad, Kristofor K.; Phillips, Tom R.; Power, Christopher

    2010-01-01

    Computational analysis of feline immunodeficiency virus (FIV) RNA sequences indicated that common FIV strains contain a rev response element (RRE) defined by a long unbranched hairpin with 6 stem-loop sub-domains, termed stem-loop A (SLA). To examine the role of the RNA secondary structure of the RRE, mutational analyses were performed in both an infectious FIV molecular clone and a FIV CAT-RRE reporter system. These studies disclosed that the stems within SLA (SA1, 2, 3, 4, and 5) of the RRE were critical but SA6 was not essential for FIV replication and CAT expression. These studies also revealed that the secondary structure rather than an antisense protein (ASP) mediates virus expression and replication in vitro. In addition, a single synonymous mutation within the FIV-RRE, SA3/45, reduced viral reverse transcriptase activity and p24 expression after transfection but in addition also showed a marked reduction in viral expression and production following infection. PMID:20570310

  19. ANNUAL INTERVIEWS - 2000

    CERN Multimedia

    1999-01-01

    The procedures for the above [Administrative Circular 26(Rev. 2)] will be as for 1999.The Appraisal Report form template is available as follows:For Macintosh usersConnect to the server SRV4-Home in the Appletalk zone NOVELL (as GUEST or using your Novell username and password), and then use the volume PE Division Data Disk.The Word file 'MOAS FORM' is available in the folder COM, folder Public.For PC usersStart Word; in File + New, choose document 'CERN MOAS FORM' in CERN Template.In view of the wide use of the form template, and to reduce use of paper, only the first page, pre-printed with staff members' individual data, will be distributed to divisions on request. Otherwise, this data will be transmitted electronically only.Users of the electronic template are asked to be careful to copy accurately the personal data.Personnel DivisionTel. 74480

  20. Annual report 2003

    International Nuclear Information System (INIS)

    2003-01-01

    Delivering products and services to nuclear power plants operators, AREVA operates in every sector of the civilian nuclear power and fuel cycle industry. This annual report 2003 provides, in seven chapters, information on persons responsible for the annual report and for auditing the financial statements, general information on the company and share capital (statute, capital, share trading, dividends), information on company operations, changes and future prospects, assets, financial position and financial performance, corporate governance, recent developments and future prospects. (A.L.B.)

  1. Annual report June 1988

    International Nuclear Information System (INIS)

    1988-01-01

    This annual report reviews the activities of the National Accelerator Centre until June 1988. The 200 MeV cyclotron facility, the Pretoria cyclotron facility and the Van De Graaff facility are discussed in detail. Aspects of the 200 MeV cyclotron facility examined are, inter alia: the injector cyclotrons, the separated-sector cyclotron, the control system, the beam transport system and radioisotope production. Separate abstracts were prepared for the various subdivisions contained in this annual report

  2. Natural gas annual 1995

    International Nuclear Information System (INIS)

    1996-11-01

    The Natural Gas Annual provides information on the supply and disposition of natural gas to a wide audience including industry, consumers, Federal and State agencies, and educational institutions. The 1995 data are presented in a sequence that follows natural gas (including supplemental supplies) from its production to its end use. This is followed by tables summarizing natural gas supply and disposition from 1991 to 1995 for each Census Division and each State. Annual historical data are shown at the national level

  3. Natural gas annual 1993

    International Nuclear Information System (INIS)

    1994-01-01

    The Natural Gas Annual provides information on the supply and disposition of natural gas to a wide audience including industry, consumers, Federal and State agencies, and educational institutions. The 1993 data are presented in a sequence that follows natural gas (including supplemental supplies) from its production to its end use. Tables summarizing natural gas supply and disposition from 1989 to 1993 are given for each Census Division and each State. Annual historical data are shown at the national level

  4. Natural gas annual 1991

    International Nuclear Information System (INIS)

    1992-01-01

    The Natural Gas Annual provides information on the supply and disposition of natural gas to a wide audience including industry, consumers, Federal and State agencies, and educational institutions. The 1991 data are presented in a sequence that follows natural gas (including supplemental supplies) from its production to its end use. Tables summarizing natural gas supply and disposition form 1987 to 1991 are given for each Census Division and each State. Annual historical data are shown at the national level

  5. Paul Scherrer Institut Annual Report 1998: General Volume

    Energy Technology Data Exchange (ETDEWEB)

    Salzmann, M [ed.

    1999-09-01

    This annual report presents an overview of the work performed by the PSI research departments including information on new developments connected with the various accelerators and on the status of the Swiss Light Source project (SLS). Details on the organizational and financial structure of the Institute are also provided This annual report is also available in German under the title `PSI Jahresbericht 1998; Allgemeiner Teil`.figs.

  6. Resposta imunitária à vacinação conjuntival com a estirpe Rev.1 de Brucella melitensis em ovinos e caprinos Serological response of sheep and goats to conjunctival Brucella melitensis Rev.1 vaccine

    Directory of Open Access Journals (Sweden)

    P. Poeta

    2003-04-01

    Full Text Available The live B. melitensis Rev.1 strain is considered the best vaccine available for the prophylaxis of brucellosis in small ruminants, especially when used at the standard dose by the conjunctival route. In the present study a 1´ 10(9 CFU dose for both sheep and goats conjunctivally vaccinated was tested to evaluate the duration of serological responses. Conjunctival vaccination with Rev. 1 performed in adult animals induced a rapid rise in serological titres as measured by Rose Bengal Plate Test (RBPT, Complement Fixation Test (CF and Modified Rose Bengal Plate Test (MRBPT. Titres then decreased and became negative in most animals by four months after vaccination (except MRBPT. The goats responded better to the vaccination than the sheep as one month after vaccination 100% of the goats revealed positive results to RB and RBM and 93.4% to FC test. The RBM was the one that detected more positive animals along the study.

  7. Administrative circulars No. 22A (rev. 1) – Award of additional periods of membership in the Pensions Fund for long-term shift work and No. 22B (rev. 1) – Compensation for long-term shift work hours

    CERN Multimedia

    HR Department

    2011-01-01

    Administrative Circulars No. 22A (Rev. 1) entitled "Award of additional periods of membership in the Pension Fund for long-term shift work" and No. 22B (Rev.1) entitled “Compensation for long-term shift work hours”, adopted following discussion in the Standing Concertation Committee meeting of 21 September 2010 and entering into force on 1 March 2011, are available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp They cancel and replace Administrative Circulars No. 22A and 22B entitled "Award of additional periods of membership in the Pension Fund to shift workers (Early Departure)” and “Duration and special compensation for shift work” of January 2000. This new version clarifies, in particular, the compensation of effective long-term shift work hours. Department Head Office  

  8. Stock Status

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data inform the public of the most recent stock status for all stocks (FSSI and non-FSSI) in the fishery management unit contained in a fishery managment plan....

  9. HRensembleHR. High resolution ensemble for Horns Rev. Final project report; Offshore wind power

    Energy Technology Data Exchange (ETDEWEB)

    2010-03-15

    The wind farm output of an offshore-farm such as Horns Rev changes between nearly constant output to highly variable power output. A balance responsible will therefore benefit from knowing the variability of a wind farm in advance. Some understanding of the observed variability and the corresponding forecast error on offshore wind farms had been gathered in the past few years, while a large fraction (about 60%) of the error still lacked understanding and required further intense research. This was the outset at the beginning of the HREnsemble project. Results from the wave study, variability study, ocean coupling, findings from the sensitivity experiments, the iEnKF short-term forecast and finally the demonstration phase have given significant synergy. The most basic research result in the project is that the two empirical mode decomposition approaches, Hilbert-Huang and later the Ensemble Empirical Mode Decomposition (EEMD). Both approaches confirmed that significant variability exists in offshore conditions. It was found that the variability of the short time-scales (24 minutes) are either not explicitly visible in the grid-scale of the NWP models or in the best case significantly smoothed out in all of the tested model configurations. If we interpret 2/3 of the variability due to vertical waves not present in the mean flow and 1/3 of the variability due to meso-scale weather, then the model results and EEMD are consistent. We can however not verify this theory. At present we do not know if EEMD counts neither the events correct nor whether the ensemble forecast suppresses variability. The existence of variability above the time-scale related to friction between ocean waves and air can in fact explain some of the inconsistent results published in the literature and set a question mark behind the correctness of the calculation of friction in wave, ocean and weather modelling. (LN)

  10. Medicare Update: Annual Wellness Visit

    Science.gov (United States)

    ... counseling services or programs, designed to reduce risk factors, such as for weight loss, smoking cessation, fall prevention, and nutrition. • Review of the responses to the Health Risk Assessment Prepared by Leslie Fried, Alzheimer’s Association Medicare Advocacy Project. Rev. Feb 1, 2012 ...

  11. NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

    Science.gov (United States)

    Güttler, Thomas; Madl, Tobias; Neumann, Piotr; Deichsel, Danilo; Corsini, Lorenzo; Monecke, Thomas; Ficner, Ralf; Sattler, Michael; Görlich, Dirk

    2010-11-01

    Classic nuclear export signals (NESs) confer CRM1-dependent nuclear export. Here we present crystal structures of the RanGTP-CRM1 complex alone and bound to the prototypic PKI or HIV-1 Rev NESs. These NESs differ markedly in the spacing of their key hydrophobic (Φ) residues, yet CRM1 recognizes them with the same rigid set of five Φ pockets. The different Φ spacings are compensated for by different conformations of the bound NESs: in the case of PKI, an α-helical conformation, and in the case of Rev, an extended conformation with a critical proline docking into a Φ pocket. NMR analyses of CRM1-bound and CRM1-free PKI NES suggest that CRM1 selects NES conformers that pre-exist in solution. Our data lead to a new structure-based NES consensus, and explain why NESs differ in their affinities for CRM1 and why supraphysiological NESs bind the exportin so tightly.

  12. ADMINISTRATIVE CIRCULAR No. 25 (REV. 3) - Special provisions for the fire and rescue service governing working and rest time

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 25 (Rev. 3) entitled “Special provisions for the Fire and Rescue Service governing working and rest time”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 28 September 2012 and entering into force in October 2012, is available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp This Circular is applicable to staff members of the Fire and Rescue Service It cancels and replaces Administrative Circular No. 25 (Rev. 2) entitled “Shift work – Special provisions for the Fire and Rescue Service” of April 2003. This new version takes into account the new organisation of the Fire and Rescue Service, members of which will henceforth not exclusively perform their functions in the context of shift work, but also during reference working hours and during stand-by duty. Additionally, applicable limits regarding working and rest times an...

  13. Operational Circular No.2 (Rev. 2) - Conditions of access to the fenced parts of the CERN site

    CERN Multimedia

    2014-01-01

    Operational Circular No. 2 (Rev. 2) entitled “Conditions of access to the fenced parts of the CERN site” and its “implementation measures”, approved by the Director-General following discussion at the Standing Concertation Committee meeting on 20 May 2014 and entering into force on 1 September 2014, are available on the intranet site of the Human Resources Department (see here).   This circular is applicable to members of the personnel and other persons concerned. It cancels and replaces Operational Circular No. 2 (Rev. 1) entitled “Conditions of access to the fenced parts of the CERN site”, of April 1998. In particular, the revised circular provides for the possibility of mandating a person responsible for the proper implementation of the circular, specifies the rules relating to vehicles allowed on the site and the respective responsibilities of their owners, and relaxes certain administrative formalities in case of loss, theft or di...

  14. Operational Circular No. 2 (Rev. 3) - Conditions of access to the fenced parts of the CERN site

    CERN Multimedia

    HR Department

    2015-01-01

    Operational Circular No. 2 (Rev. 3) entitled "Conditions of access to the fenced parts of the CERN site", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 24 September 2015, is now available via this link.   This revised circular cancels and replaces Operational Circular No. 2 (Rev. 2) also entitled "Conditions of access to the fenced parts of the CERN site", of September 2014. The circular was revised predominantly in order to specify that access to the CERN site is granted to CERN Pension Fund beneficiaries only provided that they are actually in receipt of payments from the Fund; and to allow the Director-General to permit special types of vehicles on site, such as trailers. It also includes a certain number of text improvements and an updated version of the implementation measures, in particular with regard to vehicle identification, road traffic and parking.  

  15. HRensembleHR. High resolution ensemble for Horns Rev. Final project report. Executive summary; Offshore wind power

    Energy Technology Data Exchange (ETDEWEB)

    2010-03-15

    The development of offshore wind power results in more energy production per area unit and new requirements to the generation forecasts. Measurements from Horns Rev and ensemble forecasts were used to upgrade forecasting tools for the relevant periods and time scales. The most significant development is a new algorithm for short-term forecasts that combines any relevant online measurements by means of ensemble forecasts. (ln)

  16. Comment on "Total Negative Refraction in Real Crystals for Ballistic Electrons and Light" (Phys. Rev. Lett. 91, 157404 (2003))

    OpenAIRE

    Yau, H. -F.; Liu, J. -P.; Ke, B.; Kuo, C. -H.; Ye, Z.

    2003-01-01

    Recently, Zhang et al. (Phys. Rev. Lett. 91, 157404 (2003)) have demonstrated that an amphoteric refraction, i. e. both positive and negative refraction, may prevail at the interface of two uniaxial anisotropic crystals when their optical axes are in different directions. The authors subsequently made a correspondence between such a refraction with the negative refraction expected for Left Handed Materials (LHMs). Here we comment that the amphoteric refraction can be observed even with one un...

  17. Annual report 1976

    International Nuclear Information System (INIS)

    1977-01-01

    This annual report is the fifth issued in English from the Tandem Accelerator Laboratory in Uppsala since research was started in November 1970. It covers work performed during the calendar year 1976 and updates information given in earlier annual reports with regard to laboratory facilities such as computer configuration and layout of the experimental area. The descriptions of the research projects are also in general more detailed than usual and may sometime contain results obtained before 1976 in order to avoid too many references to earlier annual reports. It has, for instance, been thought of interest to make the sections on the study of beam foil excitation of atoms and on the measurements of nuclear deformations by the REPREC method quite extensive. (Auth.)

  18. Petroleum supply annual 1992

    International Nuclear Information System (INIS)

    1993-01-01

    The Petroleum Supply Annual (PSA) contains information on the supply and disposition of crude oil and petroleum products. The publication reflects data that were collected from the petroleum industry during 1992 through annual and monthly surveys. The PSA is divided into two volumes. The first volume contains four sections: Summary Statistics, Detailed Statistics, Refinery Capacity, and Oxygenate Capacity each with final annual data. This second volume contains final statistics for each month of 1992, and replaces data previously published in the Petroleum Supply Monthly (PSM). The tables in Volumes 1 and 2 are similarly numbered to facilitate comparison between them. Explanatory Notes, located at the end of this publication, present information describing data collection, sources, estimation methodology, data quality control procedures, modifications to reporting requirements and interpretation of tables. Industry terminology and product definitions are listed alphabetically in the Glossary

  19. Evaluación externa en la LOMCE. Reválidas, exclusión y competitividad

    Directory of Open Access Journals (Sweden)

    Ángel I. Pérez Gómez

    2014-01-01

    Full Text Available La evaluación de las competencias o cualidades humanas que cada aprendiz ha de desarrollar de manera singular para afrontar la complejidad de la era digital contemporánea es incompatible con las reválidas, test y pruebas externas estandarizadas, iguales para todos. Las cualidades más importantes del aprendizaje en la era digital —autodirección, iniciativa, creatividad, pensamiento crítico, solución de problemas y autoevaluación— son difícilmente evaluables mediante instrumentos baratos y masivos «de papel y lápiz», como los test estandarizados o las reválidas externas; requieren, por el contrario, herramientas y procesos más complejos, plurales y flexibles como la observación continua de los equipos docentes sobre el quehacer y los procesos y productos de los aprendices (Soto Gómez, 2014. La LOMCE,1 fiel exponente de la pedagogía conservadora del movimiento GERM,2 recupera las reválidas, pues apuesta por la estandarización de aprendizajes superficiales en lugar de potenciar el desarrollo singular de cada aprendiz hasta el máximo de sus posibilidades.

  20. An analysis of international situation concerning nuclear security. Focused on the revision to INFCIRC/225/Rev.5

    International Nuclear Information System (INIS)

    Inamura, Tomoaki; Tanabe, Tomoyuki

    2011-01-01

    Since the September 11 attacks in 2001, counterterrorism measures have become not just domestic issues but critical issues that need international cooperation. Various nuclear security measures are in place as part of international counterterrorism measures. This report looks at the trend of international nuclear security measures to get implications for Japan, focusing on INFCIRC/225/Rev.5, an international guideline for physical protection of nuclear materials and nuclear facilities drawn up by IAEA. The observations of this report are as follows: 1) While legally binding nuclear security measures such as multilateral treaties and United Nations Security Council Resolutions impose minimum requirements on individual countries, the approaches led by IAEA or individual countries or private associations aim at more detailed consideration or information sharing to further improve nuclear security. 2) INFCIRC/225/Rev.5 comprises new concepts such as risk-based physical protection and nuclear security culture, as well as extended range of threats such as insiders or stand-off attacks and broader scope of measures to response. Japan should consider incorporation of INFCIRC/225/Rev.5 to its national laws and regulations putting in mind that it may have heavy influence and that Japan pledged to role leadership about nuclear security to international society. (author)

  1. Safety and efficacy of reduced doses of Brucella melitensis strain Rev. 1 vaccine in pregnant Iranian fat-tailed ewes

    Directory of Open Access Journals (Sweden)

    Mohammad Ebrahimi

    2012-12-01

    Full Text Available Brucellosis is one of the most important zoonotic diseases and is a significant cause of abortion in animals. Brucella melitensis strain Rev. 1 is recommended as the most effective vaccine for small ruminants but the application of full doses in adult animals is restricted. This study was conducted to determine a proper reduced dose of vaccine which confers protection but which is not abortifacient in Iranian fat-tailed sheep. A total of 51 non-vaccinated pregnant ewes were divided into three main groups and several subgroups. Ewes in different groups were vaccinated at different stages of pregnancy and various subgroups were subcutaneously immunised with different quantities of the micro-organism (7.5 × 106, 106, 5 × 105. Ewes again became pregnant a year later and were challenged with the wild-type strain to evaluate the protection conferred. Results revealed that the proportion of vaccination-induced abortions was significantly higher in ewes immunised with 7.5 × 106 Rev. 1 organisms than in those which received 106 or 5 × 105 bacteria. While 80% of non-vaccinated ewes aborted after challenge, none of the vaccinated ewes aborted post-challenge. This study indicated that a reduced dose of Rev. 1 vaccine containing 106 or 5 × 105 live cells could be safely used to induce protection in Iranian fat-tailed sheep at various stages of pregnancy.

  2. Natural gas annual 1997

    International Nuclear Information System (INIS)

    1998-10-01

    The Natural Gas Annual provides information on the supply and disposition of natural gas to a wide audience including industry, consumers, Federal and State agencies, and educational institutions. The 1997 data are presented in a sequence that follows natural gas (including supplemental supplies) from its production to its end use. This is followed by tables summarizing natural gas supply and disposition from 1993 to 1997 for each Census Division and each State. Annual historical data are shown at the national level. 27 figs., 109 tabs

  3. Natural gas annual 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-10-01

    The Natural Gas Annual provides information on the supply and disposition of natural gas to a wide audience including industry, consumers, Federal and State agencies, and educational institutions. The 1997 data are presented in a sequence that follows natural gas (including supplemental supplies) from its production to its end use. This is followed by tables summarizing natural gas supply and disposition from 1993 to 1997 for each Census Division and each State. Annual historical data are shown at the national level. 27 figs., 109 tabs.

  4. International energy annual 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The International Energy Annual presents an overview of key international energy trends for production, consumption, imports, and exports of primary energy commodities in over 220 countries, dependencies, and areas of special sovereignty. Also included are population and gross domestic product data, as well as prices for crude oil and petroleum products in selected countries. Renewable energy reported in the International Energy Annual includes hydroelectric power, geothermal, solar, and wind electric power, biofuels energy for the US, and biofuels electric power for Brazil. New in the 1996 edition are estimates of carbon dioxide emissions from the consumption of petroleum and coal, and the consumption and flaring of natural gas. 72 tabs.

  5. Annual report 2000

    International Nuclear Information System (INIS)

    2001-07-01

    Article VI.J of the Agency's Statute requires the Board of Governors to submit 'an annual report to the General Conference concerning the affairs of the Agency and any projects approved by the Agency'. This report covers the period 1 January to 31 December 2000

  6. IRI annual report 1989

    International Nuclear Information System (INIS)

    1990-01-01

    In this annual report of the Dutch Interfacultary Reactor Institute, summary reports are presented of current research and teaching activities during 1989 of the departments radiochemistry, radiation chemistry, radiation physics and reactor physics, operation and maintenance of, and experiments with the Delft Hoger Onderwijs reactor, nuclear instrumentation projects and supporting services. (H.W.). 299 refs.; 2 figs.; 7 tabs

  7. Annual report 1981

    International Nuclear Information System (INIS)

    1981-12-01

    This annual report contains short descriptions of the work done at the named institute. These concern the study of hyperfine interactions, experiments with synchroton radiation, experiments at storage rings, and experiments at CERN. Furthermore, a list of publications, contributions to conferences and these is presented. (HSI) [de

  8. CSIR Annual report 1966

    CSIR Research Space (South Africa)

    CSIR

    1966-01-01

    Full Text Available This report presents the twenty second annual report of the Council for Scientific and Industrial Research. The report covers the period from the 1st January, 1966, to the 31st December 1966. Balance sheets and statements of income and expenditure...

  9. Annual Report - ESCELSA - 1997

    International Nuclear Information System (INIS)

    1998-01-01

    The annual report of ESCELSA - Brazilian electric power distribution company - introduces the following main topics: state of Espirito Santo; strategic focus; financial performance; relation with investors; energy sales; market overview; market expansion; customers; technological stream; measuring quality; electric system; investments; protecting the environment; and resource allocation

  10. Annual Conference Abstracts

    Science.gov (United States)

    Journal of Engineering Education, 1972

    1972-01-01

    Includes abstracts of papers presented at the 80th Annual Conference of the American Society for Engineering Education. The broad areas include aerospace, affiliate and associate member council, agricultural engineering, biomedical engineering, continuing engineering studies, chemical engineering, civil engineering, computers, cooperative…

  11. HASYLAB annual report 1987

    International Nuclear Information System (INIS)

    1988-01-01

    This annual report contains extended abstracts about the work performed at HASYLAB together with a list of publications, speeches, and theses. The work concerns technical developments, the study of the electronic structure of atoms, molecules, solids, surfaces, and liquids, X-ray structure studies of solids and interfaces, molecular biology, further applications of synchrotron radiation, and experimental developments. (HSI)

  12. Annual report 1996

    International Nuclear Information System (INIS)

    1996-01-01

    This annual report presents an evaluation of activities of the Entomology Unit of the FAO/IAEA Agriculture and Biotechnology Laboratory, Seibersdorf. The major themes of the report include mass rearing and quality control in Tsetse fly and research on Medfly genetic sexing strains

  13. Annual report 1999

    International Nuclear Information System (INIS)

    1999-01-01

    This annual report presents an evaluation of activities of the Entomology Unit of the FAO/IAEA Agriculture and Biotechnology Laboratory, Seibersdorf. The major themes of the report include mass rearing and quality control in Tsetse fly and research on Medfly genetic sexing strains

  14. Annual report 1997

    International Nuclear Information System (INIS)

    1997-01-01

    This annual report presents an evaluation of activities of the Entomology Unit of the FAO/IAEA Agriculture and Biotechnology Laboratory, Seibersdorf. The major themes of the report include mass rearing and quality control in Tsetse fly and research on Medfly genetic sexing strains

  15. CSIR Annual report 1968

    CSIR Research Space (South Africa)

    CSIR

    1968-01-01

    Full Text Available This report presents the twenty fourth annual report of the Council for Scientific and Industrial Research. The report covers the period from the 1st January, 1968, to the 31st December 1968. Balance sheets and statements of income and expenditure...

  16. CSIR Annual report 1971

    CSIR Research Space (South Africa)

    CSIR

    1971-01-01

    Full Text Available This report presents the twenty seventh annual report of the Council for Scientific and Industrial Research. The report covers the period from the 1st January, 1971, to the 31st December 1971. Balance sheets and statements of income and expenditure...

  17. CSIR Annual report 1970

    CSIR Research Space (South Africa)

    CSIR

    1970-01-01

    Full Text Available This report presents the twenty sixth annual report of the Council for Scientific and Industrial Research. The report covers the period from the 1st January, 1970, to the 31st December 1970. Balance sheets and statements of income and expenditure...

  18. CSIR Annual report 1969

    CSIR Research Space (South Africa)

    CSIR

    1969-01-01

    Full Text Available This report presents the twenty fifth annual report of the Council for Scientific and Industrial Research. The report covers the period from the 1st January, 1969, to the 31st December 1969. Balance sheets and statements of income and expenditure...

  19. International energy annual, 1991

    International Nuclear Information System (INIS)

    1992-12-01

    This report is prepared annually and presents the latest information and trends on world energy production and consumption for petroleum, natural gas, coal, and electricity. Trade and reserves are shown for petroleum, natural gas, and coal. Prices are included for selected petroleum products. Production and consumption data are reported in standard units as well as British thermal units (Btu) and joules

  20. Uranium industry annual 1998

    International Nuclear Information System (INIS)

    1999-01-01

    The Uranium Industry Annual 1998 (UIA 1998) provides current statistical data on the US uranium industry's activities relating to uranium raw materials and uranium marketing. It contains data for the period 1989 through 2008 as collected on the Form EIA-858, ''Uranium Industry Annual Survey.'' Data provides a comprehensive statistical characterization of the industry's activities for the survey year and also include some information about industry's plans and commitments for the near-term future. Data on uranium raw materials activities for 1989 through 1998, including exploration activities and expenditures, EIA-estimated reserves, mine production of uranium, production of uranium concentrate, and industry employment, are presented in Chapter 1. Data on uranium marketing activities for 1994 through 2008, including purchases of uranium and enrichment services, enrichment feed deliveries, uranium fuel assemblies, filled and unfilled market requirements, and uranium inventories, are shown in Chapter 2. The methodology used in the 1998 survey, including data edit and analysis, is described in Appendix A. The methodologies for estimation of resources and reserves are described in Appendix B. A list of respondents to the ''Uranium Industry Annual Survey'' is provided in Appendix C. The Form EIA-858 ''Uranium Industry Annual Survey'' is shown in Appendix D. For the readers convenience, metric versions of selected tables from Chapters 1 and 2 are presented in Appendix E along with the standard conversion factors used. A glossary of technical terms is at the end of the report. 24 figs., 56 tabs

  1. KTA annual report 1980

    International Nuclear Information System (INIS)

    The annual report gives an overview of the rulemaking work in the individual fields as well as other activities, such as meetings, international codes of rules, and publications. KTA organization, including its administration and funds is listed. (orig./HP) [de

  2. IRI annual report 1989

    International Nuclear Information System (INIS)

    1990-01-01

    In this annual report of the Dutch Interfacultary Reactor Institute, summary reports are presented of current research and teaching activities during 1989 of the departments radiochemistry, radiation chemistry, radiation physics and reactor physics, operation and maintenance of, and experiments with the Delft Hoger Onderwijs reactor, nuclear instrumentation projects and supporting services. (H.W.). 145 refs.; 20 figs.; 4 fotos; 2 tabs

  3. Annual report 1981

    International Nuclear Information System (INIS)

    1982-01-01

    In this annual report the work done at the named Institute is described. This concerns particle and fields in the solar system, infrared astronomy, X-ray astronomy, γ-astronomy, and molecule spectroscopy. A list of publications is added. (HSI)

  4. ANCLI annual report 2003

    International Nuclear Information System (INIS)

    2003-01-01

    The National Association for the Information Local Commissions (ANCLI) was created in september 1999. This association aims to develop an exchange and information network for the information local commissions. In this framework it develops information sheets, Internet site, nuclear centers visits, colloquium and formations organizations. This report presents the annual activities for the year 2003. (A.L.B.)

  5. ANCLI annual report 2004

    International Nuclear Information System (INIS)

    2004-01-01

    The National Association for the Information Local Commissions (ANCLI) was created in september 1999. This association aims to develop an exchange and information network for the information local commissions. In this framework it develops information sheets, Internet site, nuclear centers visits, colloquium and formations organizations. This report presents the annual activities for the year 2004. (A.L.B.)

  6. Annual Report 2008

    Energy Technology Data Exchange (ETDEWEB)

    Keeley, N; Skalski, J [The Andrzej Soltan Institute for Nuclear Studies, Swierk-Otwock (Poland)

    2009-07-01

    The ''Annual Report 2008'' describes activities of Andrzej Soltan Institute for Nuclear Studies in 2008. Report consists of two parts. First one consists of general information about location, management, scientific council, personnel, financial support and conferences while the second one describes the scientific activity of Institute. A Foreword to all report written by Director of the Institute prof. Grzegorz Wrochna is also given.

  7. TIARA annual report 2004

    International Nuclear Information System (INIS)

    Ohara, Yoshihiro; Arakawa, Kazuo; Tanaka, Shigeru; Narumi, Kazumasa; Yoshida, Masaru; Itoh, Hisayoshi; Yoshikawa, Masato; Tanaka, Atsushi; Kobayashi, Yasuhiko; Fukuda, Mitsuhiro; Otsubo, Michiro; Yokota, Watalu; Nakamura, Yoshiteru

    2006-01-01

    This annual report describes research and development activities which have been performed with the TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities from April 1, 2004 to March 31, 2005. The 126 of the presented papers are indexed individually. A list of publications, the type of research collaborations and organization of TIARA are also given as appendices. (J.P.N.)

  8. Annual Report 2000

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    The Institut Laue-Langevin (ILL) is an international research center using neutrons to probe the microscopic structure and dynamics of a broad range of materials. This annual report presents the ILL activities in 2000: the scientific highlights, the Millennium programme and the new developments, the workshops organized by the ILL, the experimental programme and the publications. (A.L.B.)

  9. International Energy Annual, 1992

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-14

    This report is prepared annually and presents the latest information and trends on world energy production and consumption for petroleum, natural gas, coal, and electricity. Trade and reserves are shown for petroleum, natural gas, and coal. Prices are included for selected petroleum products. Production and consumption data are reported in standard units as well as British thermal units (Btu) and joules.

  10. ANCLI annual report 2002

    International Nuclear Information System (INIS)

    2002-01-01

    The National Association for the Information Local Commissions (ANCLI) was created in september 1999. This association aims to develop an exchange and information network for the information local commissions. In this framework it develops information sheets, Internet site, nuclear centers visits, colloquium and formations organizations. This report presents the annual activities for the year 2002. (A.L.B.)

  11. Annual General Meetings

    OpenAIRE

    2009-01-01

    We have produced this information booklet to explain why companies must – by law – hold an Annual General Meeting (AGM). The laws which cover AGMs are known as the Companies Acts. This guide gives only a summary of the rules for AGMs. If you have a concern about the AGM of a particular company, you should get independent legal advice.

  12. Annual report 1981, annex

    International Nuclear Information System (INIS)

    1982-01-01

    This volume entitled ''Annex to the annual report'' deals in more detail with the scientific works of the I.L.L.: the scientific activity of theoricians; experimental reports on inelastic scattering in simple solids, crystallographic and magnetic structures, fluids and amorphous substances, imperfections, biology, chemistry

  13. Annual report 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    This annual report presents an evaluation of activities of the Entomology Unit of the FAO/IAEA Agriculture and Biotechnology Laboratory, Seibersdorf. The major themes of the report include mass rearing and quality control in Tsetse fly and research on Medfly genetic sexing strains.

  14. Annual Report 2006

    International Nuclear Information System (INIS)

    Gawlikowicz, W.; Pienkowski, L.

    2007-03-01

    The Annual Report of the Heavy Ion Laboratory, Warsaw University describes the activities of Laboratory in 2006. The document consist of four parts: 'Laboratory Overview', 'Experiments and Experimental Set-ups', 'Experiments Using the Outside Facilities' and 'General Information on HIL Activities'. An 'Introduction' written by director of the Department prof. J. Jastrzebski is also given

  15. Annual report 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    The annual report from IKU (Continental Shelf Institute) in Norway deals with the market adjustment of research activities at the institute as a result of offshore cost-cutting policy in the petroleum industry. The market is about to shift focus from volume to competence. In practice, that means buying competence instead of project ideas or proposals

  16. BAM - Annual report 1975

    International Nuclear Information System (INIS)

    1976-06-01

    The annual report contains progress and activity reports of the presidential department, the departments metals and metal construction, civil engineering and building activities, organic matter, chemical safety engineering, special fields of materials testing, techniques independent of the type of material, an index, as well as general and statistic statements. (HK) [de

  17. Annual report - ENERSUL - 1999

    International Nuclear Information System (INIS)

    2000-01-01

    The annual report of ENERSUL - Brazilian electric power distribution company - introduces the following main topics: Outlook for the State of Mato Grosso do Sul; strategic focus; financial performance; relation with investors; energy sold; capacity increases; customers; customers; energy balance; performance and quality; electric system; investments; people; human resources; synergies; awards; workplace safety; social balance; and patrimonial balance

  18. 2001 annual report

    International Nuclear Information System (INIS)

    2002-01-01

    This document is the 2001 annual report of the French union of the petroleum industry (UFIP). It summarizes the highlights of the petroleum industry activity in France in 2001 and gives some additional information about the production, refining and distribution of petroleum products in the rest of the world. (J.S.)

  19. Annual Report 2007

    International Nuclear Information System (INIS)

    Zielinska, M.; Gawlikowicz, W.

    2008-03-01

    The Annual Report of the Heavy Ion Laboratory, Warsaw University describes the activities of Laboratory in 2007. The document consist of four parts: '' Laboratory Overview '', '' Experiments and Experimental Set-ups '', '' Experiments Using the Outside Facilities '' and '' General Information on HIL Activities ''. An '' Introduction '' written by director of the Department prof. J. Jastrzebski is also given

  20. International Energy Annual, 1992

    International Nuclear Information System (INIS)

    1994-01-01

    This report is prepared annually and presents the latest information and trends on world energy production and consumption for petroleum, natural gas, coal, and electricity. Trade and reserves are shown for petroleum, natural gas, and coal. Prices are included for selected petroleum products. Production and consumption data are reported in standard units as well as British thermal units (Btu) and joules

  1. 2010 AAUW Annual Report

    Science.gov (United States)

    American Association of University Women, 2010

    2010-01-01

    This report highlights some of the outstanding accomplishments of AAUW (American Association of University Women) for fiscal year 2010. This year's annual report also features stories of remarkable women who are leading the charge to break through barriers and ensure that all women have a fair chance. Sharon is working to reduce the pay gap…

  2. Annual report - ESCELSA - 1999

    International Nuclear Information System (INIS)

    2000-01-01

    The annual report of 1999 of ESCELSA - Brazilian electric power company - introduces the next main topics: state of Espirito Santo; strategic focus; financial performance; relation with investors; energy sales; customers; quality; electric system; investments; people; resources; synergies; awards; outlook; social balancing; and patrimonial balancing

  3. IKF annual report 1988

    International Nuclear Information System (INIS)

    1989-01-01

    The annual report of 1988 gives a survey of the following category of themes: nuclear physics, atom physics, nuclear methods, nuclear solid-state physics and developments of machines. Apart from the use of its own Van de Graaff accelerators the institute takes part in joint ventures in research, for example with the GSI (Association for Heavy-Ion Research) in Darmstadt. (DG) [de

  4. Annual Report 2005

    International Nuclear Information System (INIS)

    Zielinska, M.; Gawlikowicz, W.; Pienkowski, L.

    2006-05-01

    The Annual Report of the Heavy Ion Laboratory, Warsaw University describes the activities of Laboratory in 2005. The document consist of four parts: Laboratory Overview, Experiments and Experimental Set-ups, Experiments Using the Outside Facilities and General Information on HIL Activities. An Introduction written by director of the Department prof. J. Jastrzebski is also given

  5. KVI Annual Report 1982

    International Nuclear Information System (INIS)

    1983-04-01

    This annual report offers 93 informative descriptions of the current research projects at the KVI cyclotron during 1982. The projects are classed under the following heads: elastic and inelastic scattering; giant resonances; transfer and charge exchange reactions; breakup reactions; heavy ion reactions; electromagnetic and weak interactions; theoretical nuclear physics; atomic physics; nuclear solid state physics; cyclotron, computers and instrumentation; nuclear medicine; environmental studies. (Auth.)

  6. NERSC Annual Report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Hules, John; Bashor, Jon; Yarris, Lynn; McCullough, Julie; Preuss, Paul; Bethel, Wes

    2005-04-15

    The National Energy Research Scientific Computing Center (NERSC) is the premier computational resource for scientific research funded by the DOE Office of Science. The Annual Report includes summaries of recent significant and representative computational science projects conducted on NERSC systems as well as information about NERSC's current and planned systems and services.

  7. Annual report 1979

    International Nuclear Information System (INIS)

    1979-12-01

    In this annual report the work done at the named institute is described. This concerns experiments with synchrotron radiations, high energy physics experiments at the PETRA and DORIS storage rings, studies of MFS interactions, and some neutrino experiments at CERN. A list of publications is included. (HSI)

  8. Annual Report 2000

    International Nuclear Information System (INIS)

    2000-01-01

    The Institut Laue-Langevin (ILL) is an international research center using neutrons to probe the microscopic structure and dynamics of a broad range of materials. This annual report presents the ILL activities in 2000: the scientific highlights, the Millennium programme and the new developments, the workshops organized by the ILL, the experimental programme and the publications. (A.L.B.)

  9. Total 2004 annual report

    International Nuclear Information System (INIS)

    2004-01-01

    This annual report of the Group Total brings information and economic data on the following topics, for the year 2004: the corporate governance, the corporate social responsibility, the shareholder notebook, the management report, the activities, the upstream (exploration and production) and downstream (refining and marketing) operating, chemicals and other matters. (A.L.B.)

  10. NERSC Annual Report 2002

    Energy Technology Data Exchange (ETDEWEB)

    Hules, John

    2003-01-31

    The National Energy Research Scientific Computing Center (NERSC) is the primary computational resource for scientific research funded by the DOE Office of Science. The Annual Report for FY2002 includes a summary of recent computational science conducted on NERSC systems (with abstracts of significant and representative projects), and information about NERSC's current and planned systems and service

  11. Annual results 2004

    International Nuclear Information System (INIS)

    2005-01-01

    This 2004 annual evaluation of the french RTE company (electric power transport network) provides information on the 2004 results on: institutional information, financial results, customers and market, industrial resources, environment and consultation, human resources and international aspects. (A.L.B.)

  12. Annual report SNET 2003

    International Nuclear Information System (INIS)

    2004-01-01

    This annual report of the SNET (National Society of Electricity and thermic) presents the society activities and the financial report for the year 2003. The society position in the market, the environmental policy, the performance, the workers and financial data are detailed. (A.L.B.)

  13. Environment annual report 1993

    International Nuclear Information System (INIS)

    1994-01-01

    In the 1993 Environment Annual Report for BNFL, data are presented for radioactive discharges to the environment and their associated doses to the criteria group members of the public in the vicinity of Sellafield, Drigg, Chapelcross, Springfields and Capenhurst. Similarly, data are also presented for non-radioactive discharges to water and air for each site. (UK)

  14. NUFFIC Annual Report, 1977.

    Science.gov (United States)

    Netherlands Universities Foundation for International Co-operation, The Hague.

    The 1977 annual report of the Netherlands Universities Foundation for International Cooperation (NUFFIC) considers the following topics: major developments in work and policy; relationships NUFFIC has with other organizations; University Development Cooperation; developments in international education; the functioning of the Consultative Structure…

  15. CSIR Annual report 1967

    CSIR Research Space (South Africa)

    CSIR

    1967-01-01

    Full Text Available This report presents the twenty third annual report of the Council for Scientific and Industrial Research. The report covers the period from the 1st January, 1967, to the 31st December 1967. Balance sheets and statements of income and expenditure...

  16. Annual report 1982. Annex

    International Nuclear Information System (INIS)

    This is the scientific annual report 1982 of the ILL on R and D activities of the different colleges: fundamental and nuclear physics, inelastic scattering in simple solids, crystallographic and magnetic structures, fluids and amorphous substances, imperfections, biology, chemistry, theory. Abstracts of the publications published during the year are presented

  17. CSIR Annual report 1980

    CSIR Research Space (South Africa)

    CSIR

    1980-01-01

    Full Text Available This report presents the thirty-sixth annual report of the CSIR. The report covers the period 1 January, 1980 to 31 December 1980. A balance sheet and statements of income and expenditure for the financial year ended 31st March 1980, certified...

  18. NRCC annual report, 1979

    International Nuclear Information System (INIS)

    1980-11-01

    This annual report of the National Research for Computation in Chemistry (NRCC) Division describes the program of research workshops, software development, and scientific research of the Division in 1979. This year marked the first full calendar year of activity of the Division. Initial staffing in the core scientific areas was completed by the addition of a crystallographer

  19. GKSS annual report 1983

    International Nuclear Information System (INIS)

    1984-01-01

    This annual report reviews the structure and activities of the GKSS in 1983. R and D work was done on reactor safety engineering, environmental research/environmental engineering and underwater technology. It also reports on cooperation with outside partners, the organization, financing, and developments in the staff structure as well as on publications, lectures, applications for patents, etc. (UA) [de

  20. NERSC Annual Report 2005

    Energy Technology Data Exchange (ETDEWEB)

    Hules (Ed.), John

    2006-07-31

    The National Energy Research Scientific Computing Center (NERSC) is the premier computational resource for scientific research funded by the DOE Office of Science. The Annual Report includes summaries of recent significant and representative computational science projects conducted on NERSC systems as well as information about NERSC's current and planned systems and services.

  1. ELETRONUCLEAR - Annual report - 1997

    International Nuclear Information System (INIS)

    1998-01-01

    The annual activities report of 1997 of ELETRONUCLEAR - Brazilian company responsible by the electric power generation from the nuclear technology - introduces the next main topics: company vision and mission; energy production and commercialization; investments in the electric power generation; economic and financial situation; social balancing; and patrimonial balancing

  2. Mail Office annual closure

    CERN Multimedia

    2013-01-01

    On the occasion of the annual closure of CERN, there will be no mail distributed on Friday 20 December 2013 but mail will be collected in the morning. Nevertheless, you will still be able to bring your outgoing mail to Building 555-R-002 until 12 noon.  

  3. PTB annual report 1985

    International Nuclear Information System (INIS)

    1986-02-01

    The annual report presents general information on the institution's activities and the various departments, and reports on scientific work in the field of metrology and safety engineering. Brief scientific accounts refer to work in the domains of mechanics and acoustics, electricity, heat, optics, industrial metrology, atomic physics, technical and scientific services, collection and disposal of radioactive waste. (DG) [de

  4. Annual Report 2004

    International Nuclear Information System (INIS)

    Swiboda, G.

    2005-01-01

    The Annual Report of the Institute of Atomic Energy describes the results of the research activities carried out in 2004. The document consist of seven parts: General Information; Operation and safety of MARIA reactor; Radiological protection and monitoring of environment; Nuclear techniques in health and environment protection and in last section the list of published in 2004 papers is presented

  5. NIKHEF Annual Report 1982

    International Nuclear Information System (INIS)

    1983-01-01

    In this annual report 1982, the NIKHEF research programs of high-energy physics, nuclear physics and radiochemistry is described in a wide context. Next, the reports of the individual projects of section-H and section-K are described in detail. Finally, the report gives some statistical information of publications, colloquia and co-workers. (Auth.)

  6. Annual report 1987

    International Nuclear Information System (INIS)

    1988-01-01

    In this annual report of the Dutch Interfacultary Reactor Institute, summary and detailed reports are presented of current research during 1987 of the departments radiochemistry, radiation chemistry, radiation physics and reactor physics. (H.W.). 61 refs.; 13 figs.; 14 tabs

  7. NIKHEF Annual Report 1981

    International Nuclear Information System (INIS)

    1982-01-01

    This annual report presents the activities of the Dutch National Institute for Nuclear and High Energy Physics (NIKHEF) during its first year. Following a general introduction to the research areas in which NIKHEF is involved, 29 brief reports from the project groups are presented. Details concerning personnel, participation in councils and committees, finances, publications, colloquia and participation in congresses and schools are included. (Auth.)

  8. Annual Report 2010

    International Nuclear Information System (INIS)

    Palacz, M.; Zielinska, M.

    2011-06-01

    The Annual Report of the Heavy Ion Laboratory, University of Warsaw describes the activities of Laboratory in 2010. The document consist of four parts: '' Laboratory Overview '', '' Experiments at HIL '', '' Experiments Using the Outside Facilities '' and '' Appendices '' where general information on HIL activities are described. An '' Introduction '' written by director of the Heavy Ion Laboratory prof. K. Rusek is also given.

  9. CSIR Annual report 1962

    CSIR Research Space (South Africa)

    CSIR

    1962-01-01

    Full Text Available This report presents the eighteenth annual report of the CSIR. The report covers the period 1 January, 1962 to 31 December 1962. A balance sheet and statements of income and expenditure for the financial year ended 31st March 1962, certified...

  10. CSIR Annual report 1983

    CSIR Research Space (South Africa)

    CSIR

    1983-01-01

    Full Text Available This report presents the thirty ninth annual report of the CSIR. The report covers the period 1 January, 1983 to 31 December 1983. A balance sheet and statements of income and expenditure for the financial year ended 31st March 1983, certified...

  11. CSIR Annual report 1981

    CSIR Research Space (South Africa)

    CSIR

    1981-01-01

    Full Text Available This report presents the thirty seventh annual report of the CSIR. The report covers the period 1 January, 1981 to 31 December 1981. A balance sheet and statements of income and expenditure for the financial year ended 31st March 1981, certified...

  12. CSIR Annual report 1982

    CSIR Research Space (South Africa)

    CSIR

    1982-01-01

    Full Text Available This report presents the thirty eighth annual report of the CSIR. The report covers the period 1 January, 1982 to 31 December 1982. A balance sheet and statements of income and expenditure for the financial year ended 31st March 1982, certified...

  13. CSIR Annual report 1963

    CSIR Research Space (South Africa)

    CSIR

    1963-01-01

    Full Text Available This report presents the nineteenth annual report of the Council for Scientific and Industrial Research. The report covers the period from the 1st January, 1963, to the 31st December 1963. Balance sheets and statements of income and expenditure...

  14. Sustainability Annual Report 2013

    OpenAIRE

    2013-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

  15. Sustainability Annual Report 2014

    OpenAIRE

    2014-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

  16. Sustainability Annual Report 2017

    OpenAIRE

    2017-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

  17. Sustainability Annual Report 2011

    OpenAIRE

    2011-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

  18. Sustainability Annual Report 2012

    OpenAIRE

    2012-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

  19. Sustainability Annual Report 2015

    OpenAIRE

    2015-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

  20. Sustainability Annual Report 2016

    OpenAIRE

    2016-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.