Duvon, D. K.
This plan contains the Pollution Prevention (P2) Program for the Environmental Restoration Contractor (ERC). The plan outlines the activities and schedules developed by the Bechtel Hanford, Inc.(BHI) to reduce the quantity and toxicity of waste dispositioned as a result of restoration and remediation activities. The purpose of this plan is to guide ERC projects in meeting and documenting compliance with requirements for pollution prevention. This plan contains the objectives, strategy, and support activities of the ERC P2 Program
The Environmental Restoration Contractor (ERC) Publication and Graphic Services (P ampersand GS) Style and Resources Guide (Rev. 1) presents instructions, uniform conventions, guidelines, specifications, requirements, and detailed process steps that will increase efficiency and reduce costs for ERC organizations, including subcontractors. This Guide also identifies P ampersand GS capabilities that can be provided to support ERC multimedia needs
A comprehensive safety and health program is essential for reducing work-related injuries and illnesses while maintaining a safe and health work environment. This document establishes Bechtel Hanford, Inc. (BHI)/Environmental Restoration Contractor (ERC) team requirements, policies, and procedures and provides preliminary guidance to the Environmental Restoration Disposal Facility (ERDF) subcontractor for use in preparing essential safety and health documents. This health and safety plan (HASP) defines potential safety and health issues associated with operating and maintaining the ERDF. A site-specific HASP shall be developed by the ERDF subcontractor and shall be implemented before operations and maintenance work can proceed. An activity hazard analysis (AHA) shall also be developed to provide procedures to identify, assess, and control hazards or potential incidents associated with specific operations and maintenance activities
This plan contains the Environmental Restoration Contractor (ERC) Waste Minimization and Pollution Prevention (WMin/P2) Program. The plan outlines the activities and schedules developed by the ERC to reduce the quantity and toxicity of waste dispositioned as a result of restoration and remediation activities. This plan satisfies US Department of Energy (DOE) requirements including the Pollution Prevention Awareness program required by DOE Order 5400.1 (DOE 1988). This plan is consistent with Executive Order 12856 and Secretary O'Leary's pollution prevention Policy Statement of December 27, 1994, which set US and DOE pollution prevention policies, respectively. It is also consistent with the DOE Pollution Prevention Crosscut Plan, 1994, which provides guidance in meeting the DOE goals in pollution prevention. The purpose of this plan is to aid ERC projects in meeting and documenting compliance with requirements for WMin/P2. This plan contains the objectives, strategy, and support activities of the ERC Team WMin/P2 program. The basic elements of the plan are pollution prevention goals, waste assessments of major waste streams, implementation of feasible waste minimization opportunities, and a process for reporting achievements. Wherever appropriate, the ERC will integrate the pollution prevention activities in this plan into regular program activities rather than establishing separate WMin/P2 activities. Moreover, wherever possible, existing documents, procedures, and activities will be used to meet WMin/P2 requirements
The purpose of this plan is to establish the Environmental Restoration Contractor (ERC) Waste Minimization and Pollution Prevention (WMin/P2) Program and outline the activities and schedules that will be employed to reduce the quantity and toxicity of wastes generated as a result of restoration and remediation activities. It is intended to satisfy the US Department of Energy (DOE) and other legal requirements. As such, the Pollution Prevention Awareness program required by DOE Order 5400.1 is included with the Pollution Prevention Program. This plan is also intended to aid projects in meeting and documenting compliance with the various requirements for WMin/P2, and contains the policy, objectives, strategy, and support activities of the WMin/P2 program. The basic elements of the plan are pollution prevention goals, waste assessments of major waste streams, implementation of feasible waste minimization opportunities, and a process for reporting achievements. Various pollution prevention techniques will be implemented with the support of employee training and awareness programs to reduce waste and still meet applicable requirements. Information about the Hanford Site is in the Hanford Site Waste Minimization and Pollution Prevention Awareness Program Plan
This document provides a description of the functions, structure, commitments, and goals of the Environmental Restoration Contractor Safety and Hygiene Program. The current structure of the ERC Safety and Hygiene organization is described herein
This document contains the revised Environmental Restoration Contractor (ERC) Implementation Plan for compliance with the Dangerous Waste and Hazardous and Solid Waste Amendment portions of the Resource Conservation and Recovery Act (RCRA) Permit for the Treatment, Storage, and Disposal of Dangerous Waste (hereafter referred to as the open-quotes Permitclose quotes). The Permit became effective on September 28, 1994. The ERC has developed the Permit Implementation Plan to ensure that the Permit is properly implemented within the ERC project and functions. The plan contains a list of applicable permit conditions, descriptions, responsible organizations, and the status of compliance. The ERC's responsibilities for Permit implementation are identified within both project and functional organizations. Project Managers are responsible for complying with conditions specific to a particular treatment, storage, or disposal (TSD) unit. TSD-specific compliance in include items such as closure plan deliverables, reporting and record keeping requirements, or compliance with non-unit-specific tasks such as spill reporting and emergency response. Functional organizations are responsible for sitewide activities, such as coordinating Permit modifications and developing personnel training programs
DOE Policy 450.4 mandates that safety be integrated into all aspects of the management and operations of its facilities. The goal of an institutionalized Integrated Safety Management System (ISMS) is to have a single integrated system that includes Environment, Safety, and Health requirements in the work planning and execution processes to ensure the protection of the worker, public, environment, and the federal property over the life cycle of the Environmental Restoration (ER) Project. The purpose of this Environmental Restoration Contractor (ERC) ISMS Phase MI Verification was to determine whether ISMS programs and processes were institutionalized within the ER Project, whether these programs and processes were implemented, and whether the system had promoted the development of a safety conscious work culture.
K. A. Gano
This report documents the results of revegetation monitoring conducted in early May through early July 1999. Fourth-year monitoring was conducted at the Horn Rapids Landfill, Horseshoe Landfill, and Nike Landfill. Third-year monitoring was conducted on the Bridge Overlook, PSN 72/82, PSN 12/14, and the North Slope Cheatgrass Area. Second-year monitoring was conducted at the 600-104 waste site (2,4-D cleanup site); the 300-FF-1 sagebrush (Artemisia tridentata) and bitterbrush (Purshia tridentata) transplant areas, 2 16-A-25 emergency extension site; and the 200-ZP-1 pipeline. First-year monitoring was conducted at the 300 Area North Process Trench, Environmental Restoration Disposal Facility (ERDF) Mitigation sites, and the 116-C-l Restoration site
SRC Engineering Research Center for Environmentally Benign Semiconductor Manufacturing (ERC ) ** Bringing Sustainability to Semiconductor Manufacturing ** A multi-university research center leading the way to environmentally friendly semiconductor manufacturing, sponsored by the Semiconductor Research
Beckman, W.H.; Cossel, S.C.; Alhadeff, N.; Lindamood, S.B.; Beers, J.A.
The purpose of the Standards/Requirements Identification Program, developed partially in response to the Defense Nuclear Facilities Safety Board Recommendation 90-2, was to identify applicable requirements that established the Environmental Restoration Management Contractor's (ERMC) responsibilities and authorities under the Environmental Restoration Management Contract, determine the adequacy of these requirements, ascertain a baseline level of compliance with them, and implement a maintenance program that would keep the program current as requirements or compliance levels change. The resultant Standards/Requirements Identification Documents (S/RIDs) consolidate the applicable requirements. These documents govern the development of procedures and manuals to ensure compliance with the requirements. Twenty-four such documents, corresponding with each functional area identified at the site, are to be issued. These requirements are included in the contractor's management plan
This safety plan is applicable to Environmental Restoration Contractor personnel who are permanently assigned to MO-561 or regularly work in the facility. The MO-561 Facility is located in the 100-D Area at the Hanford Site in Richland, Washington. This plan will: (a) identify hazards potentially to be encountered by occupants of MO-561; (b) provide requirements and safeguards to ensure personnel safety and regulatory compliance; (c) provide information and actions necessary for proper emergency response
Zhang, Danqing; Kobayashi, Toshiyuki; Kojima, Tetsuo; Kanenishi, Kenji; Hagiwara, Yoshiaki; Abe, Masaaki; Okura, Hidehiro; Hamano, Yoshitomo; Sun, Guodong; Maeda, Masahiro; Jishage, Kou-ichi; Noda, Tetsuo; Hino, Okio
Genetic crossing experiments were performed between tuberous sclerosis-2 (Tsc2) KO and expressed in renal carcinoma (Erc) KO mice to analyze the function of the Erc/mesothelin gene in renal carcinogenesis. We found the number and size of renal tumors were significantly less in Tsc2+/-;Erc-/- mice than in Tsc2+/-;Erc+/+ and Tsc2+/-;Erc+/- mice. Tumors from Tsc2+/-;Erc-/- mice exhibited reduced cell proliferation and increased apoptosis, as determined by proliferating cell nuclear antigen (Ki67) and TUNEL analysis, respectively. Adhesion to collagen-coated plates in vitro was enhanced in Erc-restored cells and decreased in Erc-suppressed cells with siRNA. Tumor formation by Tsc2-deficient cells in nude mice was remarkably suppressed by stable knockdown of Erc with shRNA. Western blot analysis showed that the phosphorylation of focal adhesion kinase, Akt and signal transducer and activator of transcription protein 3 were weaker in Erc-deficient/suppressed cells compared with Erc-expressed cells. These results indicate that deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 KO mice and inhibits the phosphorylation of several kinases of cell adhesion mechanism. This suggests that Erc/mesothelin may have an important role in the promotion and/or maintenance of carcinogenesis by influencing cell-substrate adhesion via the integrin-related signal pathway. © 2011 Japanese Cancer Association.
The European Research Council (ERC) has awarded starting grants to Magdalena Kowalska, a member of the ISOLDE physics team, and Claude Duhr, CERN Theory Division. The funding will enable them to build their own research teams at CERN, engaging postdocs and PhD students. Magdalena Kowalska and Claude Duhr. The ERC fosters scientific excellence in Europe through competitive funding. Its grants are awarded to projects headed by researchers – both beginning-of-career and established – via an open, peer-reviewed competition. In December 2014, Magdalena Kowalska and Claude Duhr were awarded grants to pursue research in ultra-sensitive nuclear magnetic resonance (NMR) in liquids and mathematical structures in scattering amplitudes, respectively. “Our research project aims to apply an ultra-sensitive NMR technique using radioisotopes to liquids in order to study the interaction of metal ions with biological molecules such as proteins, DNA or RNA,” says Mag...
This document establishes the requirements and responsibilities for the standardized methods for installation, use, and dismantlement of glovebags within the Hanford Site Environmental Contractor Radiological Glovebag Program. This document addresses the following topics: Containment selection and fabrication, Glovebag fabrication, Containment installation and inspection, General glovebag containment work practices, Emergency situations, and Containment removal
As part of a Europe-wide effort to promote high-level research, the European Research Council (ERC) has awarded a €2.14 million grant to ALPHA spokesperson Jeffrey Hangst, which will further the collaboration’s study of the antihydrogen spectrum. The grant will be used to purchase laser spectroscopy equipment for the new ALPHA-2 set-up. ALPHA Spokesperson, Jeffrey Hangst, in front of the new ALPHA-2 set-up. The incorporation of lasers into ALPHA-2 will allow the team to take precise measurements of trapped antihydrogen. Among the new equipment financed by the grant will be a high-precision laser and stabilisation system to study the transition from the ground state to the first excited state in antihydrogen. As this spectral line is very well known in hydrogen, its study in antihydrogen will provide essential data for matter/antimatter symmetry investigations. “The grant has come at a perfect time for us,” says Jeffrey Hangst. “We wil...
strategies have C-0 irwo-enal contracting experience within the Ibm aple in protecting assets hrm CERCLA ! components and the question of what role, if...federal Crawford v. National Lead Co.40 is another government owns tens of thousands of automobiles ; example of a failed government contractor defense
This document provides the status of the preliminary hazard classification (PHC) process for the Environmental Restoration Contractor (ERC) above ground structures and groundwater and soil remediation activities currently underway for planned for fiscal year (FY) 1997. This classification process is based on current US Department of Energy (DOE), Richland Operations Office (RL) guidance for the classification of facilities and activities containing radionuclide and nonradiological hazardous material inventories. The above ground structures presented in the matrices were drawn from the Bechtel Hanford, Inc. (BHI) Decontamination and Decommissioning (D and D) Project Facility List (DOE 1996), which identifies the facilities in the RL-Environmental Restoration baseline contract in 1997. This document contains the following two appendices: (1) Appendix A, which consists of a matrix identifying PHC documents that have been issued for BHI's above ground structures and groundwater and soil remediation activities underway or planned for FY 1997, and (2) Appendix B, which consists of a matrix showing anticipated PHCs for above ground structures, and groundwater and soil remediation activities underway or planned for FY 1997. Appendix B also shows the schedule for finalization of PHCs for above ground structures with an anticipated classification of Nuclear
The inactive and surplus facilities assigned to the Environmental Restoration Contractor are shut down and have no operating production processes or production materials except for residual contamination. There is a minimal number of operating systems to support surveillance and maintenance or decontamination and decommissioning activities (D ampersand D). These systems may include heating and ventilation, air conditioning, lighting, and other electrical systems. Inactive and surplus facilities will be subject to periodic long-term surveillance to ensure the integrity of structures until D ampersand D. D ampersand D projects are of relatively short duration and end with all systems deactivated. Therefore, a rigorous in-depth maintenance program such as that required for producing nuclear facilities is not required or cost effective
Inami, Koichi; Kajino, Kazunori; Abe, Masaaki; Hagiwara, Yoshiaki; Maeda, Masahiro; Suyama, Masafumi; Watanabe, Sumio; Hino, Okio
ERC/mesothelin gene (MSLN) encodes a precursor protein, which is cleaved by proteases to generate N-ERC/mesothelin and C-ERC/mesothelin. N-ERC/mesothelin is a soluble protein, also known as megakaryocyte-potentiating factor, which is released into extracellular space. N-ERC/mesothelin is known to be a serum marker of mesothelioma. We have previously developed an enzyme-linked immunosorbent assay system for N-ERC/mesothelin, which can detect mesothelioma. C-ERC/mesothelin is expressed in normal mesothelial cell, pancreatic cancers, ovarian cancers, mesotheliomas and some other cancers. Pancreatic ductal carcinoma remains a fatal disease because its diagnosis often occurs very late. In this study, we examined ERC/mesothelin expression in human pancreatic cancer cell lines (MIA-PaCa2, PK-1, KP-3, TCC-PAN2, PK-59 and PK-45H) by reverse transcription-polymerase chain reaction and immunoblotting and N-ERC/mesothelin concentration in the supernatant of cultured cancer cells by the ELISA system. We also investigated C-ERC/mesothlein expression in human pancreatic ductal carcinoma tissues by immunostaining using 5B2 anti-mesothelin monoclonal antibody and N-ERC/mesothelin concentration in sera obtained from patients with pancreatic ductal carcinoma via ELISA. In vitro, N-ERC/mesothelin concentration in cell culture medium nearly correlated with the expression level of C-ERC/mesothelin. Although C-ERC/mesothelin was frequently expressed in human pancreatic ductal carcinoma, serum N-ERC/mesothelin concentration of cancer patients was equivalent to healthy controls. N-ERC/mesothelin was not useful as a serum marker of pancreatic ductal carcinoma, but because of frequent expression, C-ERC/mesothelin might be useful as a target of molecular imaging and immunotherapy.
This Environmental Restoration (ER) Project Systems Engineering Management Plan (SEMP) describes relevant Environmental Restoration Contractor (ERC) management processes and shows how they implement systems engineering. The objective of this SEMP is to explain and demonstrate how systems engineering is being approached and implemented in the ER Project. The application of systems engineering appropriate to the general nature and scope of the project is summarized in Section 2.0. The basic ER Project management approach is described in Section 3.0. The interrelation and integration of project practices and systems engineering are outlined in Section 4.0. Integration with sitewide systems engineering under the Project Hanford Management Contract is described in Section 5.0
Ludvigsen, Maja; Jacobsen, Christian; Maunsbach, Arvid B; Honoré, Bent
ERC-55, encoded from RCN2, is localized in the ER and belongs to the CREC protein family. ERC-55 is involved in various diseases and abnormal cell behavior, however, the function is not well defined and it has controversially been reported to interact with a cytosolic protein, the vitamin D receptor. We have used a number of proteomic techniques to further our functional understanding of ERC-55. By affinity purification, we observed interaction with a large variety of proteins, including those secreted and localized outside of the secretory pathway, in the cytosol and also in various organelles. We confirm the existence of several ERC-55 splicing variants including ERC-55-C localized in the cytosol in association with the cytoskeleton. Localization was verified by immunoelectron microscopy and sub-cellular fractionation. Interaction of lactoferrin, S100P, calcyclin (S100A6), peroxiredoxin-6, kininogen and lysozyme with ERC-55 was further studied in vitro by SPR experiments. Interaction of S100P requires [Ca(2+)] of approximately 10(-7) M or greater, while calcyclin interaction requires [Ca(2+)] of >10(-5) M. Interaction with peroxiredoxin-6 is independent of Ca(2+). Co-localization of lactoferrin, S100P and calcyclin with ERC-55 in the perinuclear area was analyzed by fluorescence confocal microscopy. The functional variety of the interacting proteins indicates a broad spectrum of ERC-55 activities such as immunity, redox homeostasis, cell cycle regulation and coagulation.
Schiffbaenker, Helene; van den Besselaar, P.A.A.
To explain lower success rates of female applicants in ERC grants, we collected data about past performance of the applicants and interviewed panel members about how selection criteria are practiced in general and specifically for female vs. male applicants. Controlling for past performance, we
Ustailieva, E.; Starren, A.
Companies function more and more in networks (i.e. contractor chains with contractors, suppliers and/or other companies. This asks for several companies/parties to work together to get the work done. Working in contractor chains is very common in sectors like maintenance, construction, cleaning, and
Blanton, M.L.; Montgomery, E.W.
The recent trend in the United States and Shell Oil Company EandP has been to increase use of contractors to do specialized work. Many companies now use contractors almost exclusively for operations such as drilling, well workovers, construction, and many specialty and routine maintenance tasks. Today, approximately 75% of Shell Oil Company's actual operating work force in EandP is contract. Clearly, HSandE considerations must become an increasingly important part of the contractor selection process. This paper reports on the Shell Oil Company's evolution from a bidder selection process to a program of Matching Owner and Contractor. Well has begun to expand efforts to make better assessments of contractor's HSandE capabilities and values in pre-bid considerations. Focus is on pre-bid evaluations to select contractors that have strong HSandE commitments and values. Contractor safety performance in this industry must be brought up to the same standards as operating companies. In Shell Oil EandP is only willing to contractors who can and are willing to do that
Bernard, R.; Doyon, J.; Paetsch, L.; Patel, P.; Skok, A.; Yuh, C.; Steinfeld, G.; O'Shea, T.
ERC has made significant accomplishments in stack height scale-up, resolved issues relevant to attainment of a long useful life for the carbonate fuel cell, and progressed towards addressing organizational and financial aspects of power plant demonstration
ITO, TOMOAKI; KAJINO, KAZUNORI; ABE, MASAAKI; SATO, KOICHI; MAEKAWA, HIROSHI; SAKURADA, MUTSUMI; ORITA, HAJIME; WADA, RYO; KAJIYAMA, YOSHIAKI; HINO, OKIO
ERC/mesothelin is expressed in mesothelioma and other malignancies. The ERC/mesothelin gene (MSLN) encodes a 71-kDa precursor protein, which is cleaved to yield 31-kDa N-terminal (N-ERC/mesothelin) and 40-kDa C-terminal (C-ERC/mesothelin) proteins. N-ERC/mesothelin is a soluble protein and has been reported to be a diagnostic serum marker of mesothelioma and ovarian cancer. Gastric cancer tissue also expresses C-ERC/mesothelin, but the significance of serum N-ERC levels for diagnosing gastric...
Betsch, M.D.; Lewis, R.A.
Demolishing outdated structures from the US Department of Energy Hanford Site in Washington, generates large quantities of waste which can be minimized. The Hanford cleanup is one of the world's largest and most complex environmental restoration efforts. Approximately 280 square miles of ground water and soil are contaminated; there are more than 80 surplus facilities, including nine shut-down nuclear reactors in various stages of decay; and there are 177 underground waste storage tanks containing highly radioactive waste. In all, 1,500 cleanup sites have been identified and the Environmental Restoration Contractor (ERC) is currently responsible for surveillance and maintenance of 170 structures. A two hour orientation training in pollution prevention was developed by the Westinghouse Hanford Company to provide all Decontamination and Decommissioning/Environmental Restoration (D ampersand D/ER) personnel with the knowledge to apply waste minimization principles during their cleanup activities. The ERC Team Pollution Prevention Workshop serves to communicate pollution prevention philosophies and influences the way D ampersand D/ER projects are conducted at the Hanford Site
Kawamata, Futoshi; Homma, Shigenori; Kamachi, Hirofumi; Einama, Takahiro; Kato, Yasutaka; Tsuda, Masumi; Tanaka, Shinya; Maeda, Masahiro; Kajino, Kazunori; Hino, Okio; Takahashi, Norihiko; Kamiyama, Toshiya; Nishihara, Hiroshi; Taketomi, Akinobu; Todo, Satoru
Lymph node metastasis is a key event of colorectal cancer (CRC) progression. Mesothelin is expressed in various types of malignant tumor and associated with an unfavorable prognosis. The full-length mesothelin (Full-ERC) is cleaved by protease into membrane-bound C-ERC/mesothelin and N-ERC/mesothelin which is secreted into the blood. The aim of this study was to examine the biological role of mesothelin in CRC by clinicopathological analysis and in vitro lymphatic invasion assay. Ninety-one cases of CRC specimens were immunohistochemically examined and the localization of mesothelin in luminal membrane and/or cytoplasm was also evaluated. Lymphatic invasion assay was also performed using the human CRC cell line, WiDr, which was transfected with Full-, N- and C-ERC/mesothelin expression plasmids (Full-WiDr, N-WiDr and C-WiDr). Immunohistochemically, "luminal membrane positive" of mesothelin was identified in 37.4 %, and correlated with lymphatic permeation and lymph node metastasis, but not with patients' prognosis. Interestingly, among the patients with lymph node metastasis (N = 38), "luminal membrane positive" of mesothelin significantly correlated with unfavorable patients' outcome. In addition, lymphatic invasion assay revealed that Full-WiDr and C-WiDr more significantly invaded human lymphatic endothelial cells than the Mock-WiDr (P ERC/mesothelin associated with lymphatic invasion of cancer in vitro.
Wobser, Hella; Gunesch, Agnetha; Klebl, Frank
Patients with biliary obstruction are at high risk to develop septic complications after endoscopic retrograde cholangiography (ERC). We evaluated the benefits of local application of antimicrobial agents into ERC contrast media in preventing post-ERC infectious complications in a high-risk study population. Patients undergoing ERC at our tertiary referral center were retrospectively included. Addition of vancomycin, gentamicin and fluconazol into ERC contrast media was evaluated in a case-control design. Outcomes comprised infectious complications within 3 days after ERC. In total, 84 ERC cases were analyzed. Primarily indications for ERC were sclerosing cholangitis (75%) and malignant stenosis (9.5%). Microbial testing of collected bile fluid in the treatment group was positive in 91.4%. Detected organisms were sensitive to the administered antimicrobials in 93%. The use of antimicrobials in contrast media was associated with a significant decrease in post-ERC infectious complications compared to non-use (14.3% vs. 33.3%; odds ratio [OR]: 0.33, 95% confidence interval [CI]: 0.114-0.978). After adjusting for the variables acute cholangitis prior to ERC and incomplete biliary drainage, the beneficial effect of intraductal antibiotic prophylaxis was even more evident (OR = 0.153; 95% CI: 0.039-0.598, p = 0.007). Patients profiting most obviously from intraductal antimicrobials were those with secondary sclerosing cholangitis. Local application of a combination of antibiotic and antimycotic agents to ERC contrast media efficiently reduced post-ERC infectious events in patients with biliary obstruction. This is the first study that evaluates ERC-related infectious complications in patients with secondary sclerosing cholangitis. Our first clinical results should now be prospectively evaluated in a larger patient cohort to improve the safety of ERC, especially in patients with secondary sclerosing cholangitis.
The current contractor evaluation system in use within the Kentucky Transportation Cabinet is based on the contractor evaluation system developed as part of SPR 212-00 "Quality Based Prequalification of Contractors." This system relies on average per...
Ito, Tomoaki; Kajino, Kazunori; Abe, Masaaki; Sato, Koichi; Maekawa, Hiroshi; Sakurada, Mutsumi; Orita, Hajime; Wada, Ryo; Kajiyama, Yoshiaki; Hino, Okio
ERC/mesothelin is expressed in mesothelioma and other malignancies. The ERC/mesothelin gene (MSLN) encodes a 71-kDa precursor protein, which is cleaved to yield 31-kDa N-terminal (N-ERC/mesothelin) and 40-kDa C-terminal (C-ERC/mesothelin) proteins. N-ERC/mesothelin is a soluble protein and has been reported to be a diagnostic serum marker of mesothelioma and ovarian cancer. Gastric cancer tissue also expresses C-ERC/mesothelin, but the significance of serum N-ERC levels for diagnosing gastric cancer has not yet been studied. We examined the latter issue in the present study as well as C-ERC/mesothelin expression in human gastric cancer tissues and cell lines. We immunohistochemically examined C-ERC/mesothelin expression in tissue samples from 50 cases of gastric cancer, and we also assessed the C-ERC/mesothelin expression in 6 gastric cancer cell lines (MKN-1, MKN-7, MKN-74, NUGC-3, NUGC-4 and TMK-1) using reverse transcription-polymerase chain reaction, flow cytometry, immunohistochemistry and immunoblotting. We also examined the N-ERC/mesothelin concentrations in the supernatants of cultured cells and in the sera of gastric cancer patients using an enzyme-linked immunosorbent assay (ELISA). N-ERC/mesothelin was detected in the supernatants of 3 gastric cancer cell lines (MKN-1, NUGC-4 and TMK-1) by ELISA, but its concentration in the sera of gastric cancer patients was almost same as that observed in the sera of the normal controls. In the gastric cancer tissues, C-ERC/mesothelin expression was associated with lymphatic invasion. N-ERC/mesothelin was secreted into the supernatants of gastric cancer cell lines, but does not appear to be a useful serum marker of gastric cancer.
Wang, Tegexibaiyin; Kajino, Kazunori; Abe, Masaaki; Tan, Ke; Maruo, Masumi; Sun, Guodong; Hagiwara, Yoshiaki; Maeda, Masahiro; Hino, Okio
ERC/mesothelin is highly expressed in malignant mesothelioma, pancreatic cancer, and ovarian cancer. It is cleaved to a 30 kDa N-terminal secretory form (N-ERC) and a 40 kDa C-terminal membranous form (C-ERC). Several functions have been reported for full-length ERC (full-ERC) and C-ERC/mesothelin, such as in cell adhesion and invasion, stimulation of cell proliferation, and the suppression of cell death. However, there have been no studies to date on the function of secretory N-ERC, despite the fact that it is abundantly secreted into the sera of mesothelioma patients. In this study, we investigated whether N-ERC could function as a secretory factor to stimulate tumor progression. Full-, N, or C-ERC was overexpressed in the human hepatocellular carcinoma cell line Huh7 that lacks endogenous expression of ERC/mesothelin. Changes in the rates of cell proliferation and cell death were determined, and the state of signal transducers was examined using various endpoints: total cell counts, trypan blue exclusion rate, BrdU incorporation rate, TUNEL assay, and the phosphorylation of ERK1/2 and Stat3. In cells overexpressing N-ERC, phosphorylation of ERK1/2 was enhanced and the rate of cell death decreased, leading to the increase of cell number. The culture medium containing the secretory N-ERC also had the activity to increase the number of cells. Our data suggested that one of the full-ERC functions reported previously was mediated by the secretory N-ERC.
Saeki, Harumi; Hashizume, Akane; Izumi, Hiroshi; Suzuki, Fujihiko; Ishi, Kazuhisa; Nojima, Michio; Maeda, Masahiro; Hino, Okio
Ovarian carcinoma has been difficult to diagnose at an early stage. Recently, it has been recognized that the measurement of blood N-ERC/mesothelin levels aids early detection in and postoperative therapeutic monitoring of patients with mesothelioma, who have been exposed to asbestos. ERC/mesothelin has also been reported to be expressed in ovarian carcinoma. We determined serum N-ERC/mesothelin levels in patients with ovarian carcinoma using an enzyme-linked immunosorbent assay (ELISA). In addition, we immunohistochemically evaluated surgically resected specimens for C-ERC/mesothelin expression. As a result, of the 32 patients with ovarian tumors (18 carcinoma, 2 borderline tumors), one patient with serous adenocarcinoma showed increased N-ERC/ mesothelin levels. Immunohistochemically, of the 20 ovarian tumor (carcinoma and borderline tumor) specimens evaluated for serum N-ERC/mesothelin, 9 (45.0%) were positive for C-ERC/mesothelin. The C-ERC/mesothelin-positive specimens were found to be serous and clear cell adenocarcinomas. If serum N-ERC/mesothelin, which is considered useful for early detection in and therapeutic monitoring of patients with mesothelioma, may also be used for ovarian carcinoma monitoring, it may be a valuable serum tumor marker for the early detection of ovarian carcinoma.
Kollmann, F.D.; Maeurer, J.; Hintze, R.E.; Adler, A.; Veltzke, W.; Lohmann, R.; Felix, R.
To evaluate the use of computed tomography (CT) in primary sclerosing cholangitis (PSC) as compared to endoscopic-retrograde cholangiography (ERC), imaging studies of 24 patients were reviewed. 19 patients were studied by ERC, 19 by CT and 14 by both. In 17 cases, ERC confirmed PSC. One cholangiogram suggested a tumor. CT reflected PSC in only 11 cases, while three patients displayed a mass lesion. Thus, ERC remains the standard imaging technique for diagnosing PSC, whereas CT proves beneficial in excluding hepatic masses. (orig.) [de
Romaneehsen, B.; Mainz Univ.; Otto, G.; Lohse, A.W.; Bittinger, F.; Herber, S.; Oberholzer, K.; Pitton, M.B.; Thelen, M.
Purpose: To compare the results of the preoperative workup consisting of endoscopic retrograde cholangiography (ERC), magnetic resonance cholangiography (MRC), and percutaneous resonance cholangiography (PTC) with the tumor extent of the surgical specimen in patients with hilar cholangiocarcinoma (hilCC). Materials and Methods: Between 9/1997 and 12/2002. 59 patients with hilCC tumor underwent surgical resection. Preoperative ERC, MRC, and PTC were analyzed, blinded for the identity of the patient, and compared with the surgical specimen. For this retrospective analysis, 55 of the initial 59 ERCs, 39 of the initial 40 MRCs and 32 of the initial 38 PTCs were available. Most of the ERCs and MRCs had been performed at referring institutions by various investigators. In 20 patients, all three imaging modalities were available for direct comparison. Results: The mean scores of the visualization of the bile ducts and tumor differ considerably for ERC, MRC and PTC, with PTC visualizing the bile ducts better than ERC (p<0.001) and MRC (p=0.019). The tumor classification according to Bismuth and Corlette was correctly predicted by ERC in 29%, by MRC in 36% and by PTC in 53%. The tumor extent was overestimated in 40% (ERC), 41% (MRC) and 31% (PTC) and underestimated in less than 10% for all modalities. Twenty patients, who underwent all three imaging modalities, were included in an additional analysis for a direct comparison of ERC, MRC and PTC. PTC provided correct or acceptable information on tumor extent in 19 of 20 patients, MRC in 15 of 20 patients, and ERC in only 11 of 20 patients. The statistical analysis revealed a significant superiority of PTC to ERC (McNemar test: p<0.01) but not to MRC (p=0.22). (orig.)
Following the External Review Committee's (ERC) Report (CERN/2444) and Council's statement after the discussions in the June 2002 Committees, the Management presents in this document an Action Plan and a time table, aiming at coherent detailing and implementation of the recommendations of the ERC.
Following the External Review Committee's (ERC) Report (CERN/2444) and Council's statement after the discussions in the June 2002 Committees, the Management presents in this document an Action Plan and a time table, aiming at coherent detailing and implementation of the recommendations of the ERC
Shiomi, Kazu; Shiomi, Satoko; Ishinaga, Yuji; Sakuraba, Motoki; Hagiwara, Yoshiaki; Miyashita, Kazuya; Maeda, Masahiro; Suzuki, Kenji; Takahashi, Kazuhisa; Hino, Okio
Knowledge of the characteristics and effective use of tumour markers for mesothelioma is essential for early-stage diagnosis of mesothelioma. We examined whether renal dysfunction influences blood concentrations of promising new tumour markers, N-ERC/mesothelin (N-ERC) and osteopontin (OPN), to an important degree. Levels of serum N-ERC and plasma OPN in 32 patients with chronic renal dysfunction, 22 of whom were on hemodialysis (CKD group), and 102 healthy volunteers were measured. Serum concentrations of N-ERC and plasma concentrations of OPN in the CKD group were significantly higher than those in volunteers, regardless of diabetes status and age. Blood concentrations of these markers increased as renal function decreased. N-ERC and OPN concentrations are significantly influenced by renal function. Therefore, the extent of renal failure must be considered when inferring the existence of tumours and chemotherapeutic response from the values of these markers in routine practice.
Fischer, Henrik; Strunk, Guido; Neuhold, Stephanie; Kiblböck, Daniel; Trimmel, Helmut; Baubin, Michael; Domanovits, Hans; Maurer, Claudia; Greif, Robert
Out-of-hospital emergency physicians in Austria need mandatory emergency physician training, followed by biennial refresher courses. Currently, both standardized ERC advanced life support (ALS) provider courses and conventional refresher courses are offered. This study aimed to compare the retention of ALS-knowledge of out-of-hospital emergency physicians depending on whether they had or had not participated in an ERC-ALS provider course since 2005. Participants (n=807) from 19 refresher courses for out-of-hospital emergency physicians answered eight multiple-choice questions (MCQ) about ALS based on the 2005 ERC guidelines. The pass score was 75% correct answers. A multivariate logistic regression analyzed differences in passing scores between those who had previously participated in an ERC-ALS provider course and those who had not. Age, gender, regularity of working as an out-of-hospital emergency physician and the self-reported number of real resuscitation efforts within the last 6months were entered as control variables. Out-of-hospital emergency physicians who had previously attended an ERC-ALS provider course had a significantly higher chance of passing the MCQ test (OR=1.60, p=0.015). Younger age (OR=0.95, pERC-ALS provider course since 2005 had a higher retention of ALS knowledge compared to non-ERC-ALS course participants. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
A. L. Johnson
This report contains a compilation of the results of vegetation monitoring data that were collected in the spring and summer of 2005 for the Environmental Restoration Contractor's revegetation and mitigation areas on the Hanford Site.
In this invited review I provide a selective overview of recent research on brain mechanisms and cognitive processes involved in auditory hallucinations. The review is focused on research carried out in the "VOICE" ERC Advanced Grant Project, funded by the European Research Council, but I also review and discuss the literature in general. Auditory hallucinations are suggested to be perceptual phenomena, with a neuronal origin in the speech perception areas in the temporal lobe. The phenomenology of auditory hallucinations is conceptualized along three domains, or dimensions; a perceptual dimension, experienced as someone speaking to the patient; a cognitive dimension, experienced as an inability to inhibit, or ignore the voices, and an emotional dimension, experienced as the "voices" having primarily a negative, or sinister, emotional tone. I will review cognitive, imaging, and neurochemistry data related to these dimensions, primarily the first two. The reviewed data are summarized in a model that sees auditory hallucinations as initiated from temporal lobe neuronal hyper-activation that draws attentional focus inward, and which is not inhibited due to frontal lobe hypo-activation. It is further suggested that this is maintained through abnormal glutamate and possibly gamma-amino-butyric-acid transmitter mediation, which could point towards new pathways for pharmacological treatment. A final section discusses new methods of acquiring quantitative data on the phenomenology and subjective experience of auditory hallucination that goes beyond standard interview questionnaires, by suggesting an iPhone/iPod app.
Pradeepkumar, K.S.; Sharma, D.N.; Abani, M.C.
This paper discusses the requirement for a state of the art Emergency Response Centre (ERC) to be developed and kept in readiness for the quick response to any nuclear or radiological emergencies. For an effective response to any major nuclear emergency an ERC having the facilities of i) environmental dose rate monitoring network established using both mobile and fixed units ii) on-line meteorological data collection and information station iii) on-line computation and prediction of isodose curves in real time and iv) properly developed and tested monitoring methodologies are essential. Vehicles with on-line data transfer facility to the ERC and equipped with different type of monitoring systems can function as Mobile Monitoring Laboratories (MMLs) and can help in quick decision making even during a radiological emergency far away from the ERC. (author)
Wolfe, Nicholas W; Clark, Nathan L
The recent explosion of comparative genomics data presents an unprecedented opportunity to construct gene networks via the evolutionary rate covariation (ERC) signature. ERC is used to identify genes that experienced similar evolutionary histories, and thereby draws functional associations between them. The ERC Analysis website allows researchers to exploit genome-wide datasets to infer novel genes in any biological function and to explore deep evolutionary connections between distinct pathways and complexes. The website provides five analytical methods, graphical output, statistical support and access to an increasing number of taxonomic groups. Analyses and data at http://csb.pitt.edu/erc_analysis/ email@example.com. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: firstname.lastname@example.org.
Long-term use of high explosives (HE) on DoD training ranges and other defense installations has in some cases resulted in contamination of soil and groundwater with residues of HE and explosive-related compounds (ERCs...
McLendon, T.; Redente, E.F.
The purpose of this manual is to provide guidance and general guidelines for the revegetation of remediation waste sites and other disturbed areas on the Hanford Site. Specific revegetation plans will be developed using guidance from this manual. Locations, resources, and funding will dictate the specific revegetation design at each disturbed area. Disturbances have occurred to some of the ecological communities of the Hanford Site. Many of these disturbances are the result of operations of the Hanford Site, including Comprehensive Environmental Response, Compensation, and Liability Act of 1980 waste sites on small portions of the Hanford Site. There were, however, extensive disturbances to the native vegetation prior to operations of the facility. These resulted from cultivation, grazing, fire, and the introduction of exotics. Revegetation planning must take into account these early disturbances, as well as the later ones
McLendon, T.; Redente, E.F.
The purpose of this manual is to provide guidance and general guidelines for the revegetation of remediation waste sites and other disturbed areas on the Hanford Site. Specific revegetation plans will be developed using guidance from this manual. Locations, resources, and funding will dictate the specific revegetation design at each disturbed area. Disturbances have occurred to some of the ecological communities of the Hanford Site. Many of these disturbances are the result of operations of the Hanford Site, including Comprehensive Environmental Response, Compensation, and Liability Act of 1980 waste sites on small portions of the Hanford Site. There were, however, extensive disturbances to the native vegetation prior to operations of the facility. These resulted from cultivation, grazing, fire, and the introduction of exotics. Revegetation planning must take into account these early disturbances, as well as the later ones.
.... Examples of computer software costs that contractors charge through indirect rates are material management systems, security systems, labor accounting systems, and computer-aided design and manufacturing...
Mori, Takanori; Tajima, Ken; Hirama, Michihiro; Sato, Tadashi; Kido, Kenji; Iwakami, Shin-Ichiro; Sasaki, Shinichi; Iwase, Akihiko; Shiomi, Kazu; Maeda, Masahiro; Hino, Okio; Takahashi, Kazuhisa
Although N-ERC/mesothelin (N-ERC) is an attractive diagnostic and treatment monitoring biomarker for malignant pleural mesothelioma (MPM), its clinical utility for predicting the prognosis has not yet been clarified. The aim of this study is to investigate whether the serum N-ERC level can accurately predict the outcome in patients with MPM. Twenty-six patients with MPM were enrolled. Serum N-ERC level was measured before and after chemotherapy. The N-ERC index was determined by the logarithm of the division of the N-ERC level after two courses of chemotherapy by the prior level. The median N-ERC index in the partial response (PR) group was significantly lower than that in patients with the stable disease (SD) plus the progressive disease (PD) group. The overall survival in the group whose median N-ERC index was lower than its median value was significantly longer than the group whose median N-ERC index was higher than its median value. The N-ERC index is therefore considered to be a useful biomarker for predicting not only the chemotherapeutic response, but also the prognosis in patients with advanced MPM.
Full Text Available This study examines whether voluntary corporate disclosure level published in annual report affects the relation between current stock return and contemporaneous annual earnings. The purpose of the study is to investigate whether the variances in corporate disclosure level published in annual report of companies listed on the Jakarta Stock Exchange (the JSX affects the value-relevance of earnings information proxied by earnings response coefficient (the ERC. This study is preliminary attempt to combine two research issues: the informativeness of earnings (ERC and the informativeness of disclosures, which have been separately investigated by previous studies. The findings are expected to give preliminary evidence about cross-sectional differences in current ERC associated with voluntary corporate disclosure level published in annual report. It is hypothesized that voluntary corporate disclosure level published in annual report has a negative effect on the ERC. To test the hypothesis, current stock returns are regressed against current earnings changes. The sample consists of 67 of annual reports of companies listed on the JSX as of December 31, 1995. The study finds evidence that voluntary corporate disclosure level published in annual report have a statistically positive effect on the ERC at 0.10 significant levels. This result remains consistent after controlling for other factors that have been shown to influence the earnings response coefficient. The result does not support the hypothesis that voluntary corporate disclosure level published in annual report has a negative effect on the ERC. The possible reason is that disclosures in annual report insufficiently reveal the information about companies’ future prospect. However, the result of sensitivity analysis using fundamental return model shows that voluntary corporate disclosure level published in annual report has a negative effect on the ERC, but not statistically significant.
Tajima, Ken; Hirama, Michihiro; Shiomi, Kazu; Ishiwata, Toshiji; Yoshioka, Masataka; Iwase, Akihiko; Iwakami, Shinichiro; Yamazaki, Mariko; Toba, Michie; Tobino, Kazunori; Sugano, Koji; Ichikawa, Masako; Hagiwara, Yoshiaki; Takahashi, Kazuhisa; Hino, Okio
It has been recently reported that soluble mesothelin-related protein (SMRP), serum mesothelin, and osteopontin (OPN) are considered as relevant biomarkers for the diagnosis of mesothelioma. The aim of this study was to investigate whether serum N-ERC/mesothelin, an NH3-terminal fragment of mesothelin, and plasma OPN reflect chemotherapeutic effect in patients with mesothelioma. Serum N-ERC/mesothelin and plasma osteopontin were determined with a sandwich enzyme-linked immunosorbent assay (ELISA) system. The average N-ERC ratio, determined by dividing the N-ERC levels following chemotherapy by those prior to chemotherapy, in the partial response (PR) group was significantly lower than that of the stable disease (SD)/progressive disease (PD) group. In contrast, the average OPN ratio, determined by dividing the OPN levels following chemotherapy by those prior to chemotherapy, in the PR group was not statistically different from that of the SD/PD group. N-ERC/mesothelin is considered as relevant in monitoring chemotherapeutic response in patients with mesothelioma.
Full Text Available In order to solve the security problem of transmission image across public networks, a new image encryption algorithm based on TD-ERCS system and wavelet neural network is proposed in this paper. According to the permutation process and the binary XOR operation from the chaotic series by producing TD-ERCS system and wavelet neural network, it can achieve image encryption. This encryption algorithm is a reversible algorithm, and it can achieve original image in the rule inverse process of encryption algorithm. Finally, through computer simulation, the experiment results show that the new chaotic encryption algorithm based on TD-ERCS system and wavelet neural network is valid and has higher security.
Boyd, Sonja; Mustonen, Harri; Tenca, Andrea; Jokelainen, Kalle; Arola, Johanna; Färkkilä, Martti A
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease leading to bile duct strictures and fibrosis, and predisposing to cholangiocarcinoma (CCA). Biliary dysplasia is a known precursor of CCA. In our unit, PSC patients undergo regular surveillance with ERC and brush cytology (BC), and liver transplantation is an option in case with biliary dysplasia. We evaluated the risk factors for biliary dysplasia and CCA based on ERC imaging, BC and liver function tests. Seven hundred and eighty-eight ERCs were performed with BC for 447 PSC patients. ERC images were evaluated using the modified Amsterdam score, neutrophilic inflammation was assessed in BC, and liver function tests were collected. Ploidy analysis with DNA flow cytometry was performed in cases with advanced PSC or previous suspicious BC/aneuploidy. The endpoint was either a benign disease course (follow-up for ≥2.4 years after the latest ERC), benign histology, biliary dysplasia or CCA. Benign disease course was seen in 424/447 (including 23 cases with biliary dysplasia), and CCA in 17 (3.8%) patients. Gallbladder carcinoma/carcinoma in situ was diagnosed in three patients. Advanced ERC findings, male gender, suspicious BC, aneuploidy in flow cytometry, inflammation, and elevation of ALP, bilirubin, ALT, AST, GGT, CEA and CA19-9 represented significant risk factors for CCA in univariate analysis. PSC patients with advanced bile duct disease and elevated liver enzymes, CEA or CA19-9, inflammation or suspicious BC are most likely to develop CCA. These patients may benefit from surveillance with BC if early liver transplantation is possible.
Fukamachi, Katsumi; Iigo, Masaaki; Hagiwara, Yoshiaki; Shibata, Koji; Futakuchi, Mitsuru; Alexander, David B; Hino, Okio; Suzui, Masumi; Tsuda, Hiroyuki
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal disease, which is usually diagnosed in an advanced stage. We have established transgenic rats carrying a mutated K-ras gene controlled by Cre/loxP activation. The animals develop PDA which is histopathologically similar to that in humans. Previously, we reported that serum levels of N-ERC/mesothelin were significantly higher in rats bearing PDA than in controls. In the present study, to determine whether serum levels of N-ERC/mesothelin correlated with tumor size, we measured N-ERC/mesothelin levels in rats bearing PDA. Increased serum levels of N-ERC/mesothelin correlated with increased tumor size. This result indicates an interrelationship between the serum level of N-ERC/mesothelin and tumor size. We next investigated the effect of chemotherapy on serum N-ERC/mesothelin levels. Rat pancreatic cancer cells were implanted subcutaneously into the flank of NOD-SCID mice. In the mice treated with 200 mg/kg gemcitabine, tumor weight and the serum level of N-ERC/mesothelin were significantly decreased compared to controls. These results suggest that serum N-ERC/mesothelin measurements might be useful for monitoring response to therapy.
Fischer, Henrik; Bachmann, Kaspar; Strunk, Guido; Neuhold, Stephanie; Zapletal, Bernhard; Maurer, Claudia; Fast, Andrea; Stumpf, Dominik; Greif, Robert
Austrian out-of-hospital emergency physicians (OOHEP) undergo mandatory biannual emergency physician refresher courses to maintain their licence. The purpose of this study was to compare different reported emergency skills and knowledge, recommended by the European Resuscitation Council (ERC) guidelines, between OOHEP who work regularly at an out-of-hospital emergency service and those who do not currently work as OOHEP but are licenced. We obtained data from 854 participants from 19 refresher courses. Demographics, questions about their practice and multiple-choice questions about ALS-knowledge were answered and analysed. We particularly explored the application of therapeutic hypothermia, intraosseous access, pocket guide use and knowledge about the participants' defibrillator in use. A multivariate logistic regression analysed differences between both groups of OOHEP. Age, gender, years of clinical experience, ERC-ALS provider course attendance and the self-reported number of resuscitations were control variables. Licenced OOHEP who are currently employed in emergency service are significantly more likely to initiate intraosseous access (OR = 4.013, p ERC-ALS provider course since 2005 have initiated more mild therapeutic hypothermia after successful resuscitation (OR = 1.670, p ERC guidelines better into clinical practice, but more training on life-saving rescue techniques needs to be done to improve knowledge and to raise these rates of application.
Segawa, Tatsuya; Hagiwara, Yoshiaki; Ishikawa, Kiyoshi; Aoki, Naoko; Maeda, Masahiro; Shiomi, Kazu; Hino, Okio
ERC/mesothelin is expressed on the normal mesothelium and some cancers such as mesothelioma or ovarian carcinoma. A splicing isoform of ERC/mesothelin (known as SMRP), which has an 82-bp insertion and codes for a C-terminus with a hydrophilic, presumably soluble, tail instead of a GPI-anchoring signal, has been reported as a useful marker for the diagnosis of mesothelioma. However, the existence of SMRP has not yet been demonstrated in the serum of mesothelioma patients. To elucidate the existence of SMRP, we have established a new enzyme-linked immunosorbent assay (ELISA) system for SMRP. The ELISA study revealed that N- and C-ERC/mesothelin were detected in sera from mesothelioma patients, but not SMRP, even in these samples. This result showed that the SMRP detected with MESOMARK kit should be lack of soluble C-terminus and indistinguishable from C-ERC/mesothelin. Further study might be necessary to demonstrate the relationship between SMRP and mesothelin.
Inami, Koichi; Abe, Masaaki; Takeda, Kazuyoshi; Hagiwara, Yoshiaki; Maeda, Masahiro; Segawa, Tatsuya; Suyama, Masafumi; Watanabe, Sumio; Hino, Okio
Mesothelioma is an aggressive cancer often caused by chronic asbestos exposure, and its prognosis is very poor despite the therapies currently used. Due to the long latency period between asbestos exposure and tumor development, the worldwide incidence will increase substantially in the next decades. Thus, novel effective therapies are warranted to improve the prognosis. The ERC/mesothelin gene (MSLN) is expressed in wide variety of human cancers, including mesotheliomas, and encodes a precursor protein cleaved by proteases to generate C-ERC/mesothelin and N-ERC/mesothelin. In this study, we investigated the antitumor activity of C-ERC/mesothelin-specific mouse monoclonal antibody, 22A31, against tumors derived from a human mesothelioma cell line, ACC-MESO-4, in a xenograft experimental model using female BALB/c athymic nude mice. Treatment with 22A31 did not inhibit cell proliferation of ACC-MESO-4 in vitro; however, therapeutic treatment with 22A31 drastically inhibited tumor growth in vivo. 22A31 induced antibody-dependent cell-mediated cytotoxicity by natural killer (NK) cells, but not macrophages, in vitro. Consistently, the F(ab')(2) fragment of 22A31 did not inhibit tumor growth in vivo, nor did it induce antibody-dependent cell mediated cytotoxicity (ADCC) in vitro. Moreover, NK cell depletion diminished the antitumor effect of 22A31. Thus, 22A31 induced NK cell-mediated ADCC and exerted antitumor activity in vivo. 22A31 could have potential as a therapeutic tool to treat C-ERC/mesothelin-expressing cancers including mesothelioma.
US Agency for International Development — CPARS is a web-based system used to input data on contractor performance. Reports from the system are used as an aid in awarding contracts to contractors that...
M. A. Bajaber; M. A. Taha
Contractor selection in Saudi Arabia is very important due to the large construction boom and the contractor role to get over construction risks. The need for investigating contractor selection is due to the following reasons; large number of defaulted or failed projects (18%), large number of disputes attributed to contractor during the project execution stage (almost twofold), the extension of the General Agreement on Tariffs and Trade (GATT) into construction industry, and finally the few ...
The ideas of collaboration and formation of scientific societies and registries for cardiac arrest were developed in the 18th century. The European Resuscitation Council (ERC) was formed in 1990. Nowadays, the ERC network consists of 30 National Resuscitation Councils (NRCs), which have an obligation to ensure that effective resuscitation services are provided and to promote education, training, and research in all aspects of resuscitation science. The central role of NRCs in decreasing the incidence of cardiac arrest may be highlighted and enhanced by the incorporation and implementation of the following suggestions. NRCs should emphasize and actively participate in acute care training of healthcare professionals and of lay rescuers. Implementation of current resuscitation guidelines should be a priority of each NRC and identification of the weakest link in the chain of survival should be a priority. Copyright © 2013 Elsevier Ltd. All rights reserved.
functions, from intelligence analysis or software development to landscaping or food service. Why does DOD use individual contractors? Going back to...that provide professional services, from research to management support. The bulk of contractors—more than 70%—provide products, and these include...10 U.S.C. Part IV: Service, Supply, and Procurement. CRS Products CRS In Focus IF10548, Defense Primer: U.S. Defense Industrial Base, by Daniel
Fitzsimmons, Tim [Dept. of Energy (DOE), Washington DC (United States). Office of Basic Energy Sciences. Division of Materials Sciences and Engineering
This volume highlights the scientific content of the 2006 Hydrogen Contractors Meeting sponsored by the Division of Materials Sciences and Engineering (DMS&E) on behalf of the Office of Basic Energy Sciences (BES) of the U. S. Department of Energy (DOE). Hydrogen Contractors Meeting held from May 16-19, 2006 at the Crystal Gateway Marriott Hotel Arlington, Virginia. This meeting is the second in a series of research theme-based Contractors Meetings sponsored by DMS&E held in conjunction with our counterparts in the Office of Energy Efficiency and Renewable Energy (EERE) and the first with the Hydrogen, Fuel Cells and Infrastructure Technologies Program. The focus of this year’s meeting is BES funded fundamental research underpinning advancement of hydrogen storage. The major goals of these research efforts are the development of a fundamental scientific base in terms of new concepts, theories and computational tools; new characterization capabilities; and new materials that could be used or mimicked in advancing capabilities for hydrogen storage.
Machida, Hiromichi; Nakaya, Yuzou; Kojima, Kojirou
We studied the usefulness of three dimensional helical CT (3D-CT) combined with drip infusion cholangiography for determining the application of laparoscopic cholecystectomy (LC) and evaluating the cholecyst severity. The subjects were 56 patients who underwent LC with preoperative 3D-CT. Particularly, in 42 patients undergoing endoscopic retrograde cholangiography (ERC) and 3D-CT simultaneously, the results with both methods were compared. The detection rates of the original site, forward and backward direction, and left and right direction in the confluence form of the cystic duct by means of 3D-CT versus ERC were 100% vs. 92.9% 92.9% vs. 71.4%, and 92.9% vs. 88.1%, respectively. Abnormal biliary distribution was visualized in 5 cases and all of them were depicted by 3D-CT. The 3D-CT was superior to ERC in terms of X-ray dose and cost. These results indicate the usefulness of 3D-CT as a LC preoperative examination. (author)
Bota, Daniela A; Alexandru-Abrams, Daniela; Pretto, Chrystel; Hofman, Florence M; Chen, Thomas C; Fu, Beverly; Carrillo, Jose A; Schijns, Virgil Ejc; Stathopoulos, Apostolos
Glioblastoma multiforme is a highy aggressive tumor that recurs despite resection, focal beam radiation, and temozolamide chemotherapy. ERC-1671 is an experimental treatment strategy that uses the patient's own immune system to attack the tumor cells. The authors report preliminary data on the first human administration of ERC-1671 vaccination under a single-patient, compassionate-use protocol. The patient survived for ten months after the vaccine administration without any other adjuvant therapy and died of complications related to his previous chemotherapies.
Ishikawa, Kiyoshi; Segawa, Tatsuya; Hagiwara, Yoshiaki; Maeda, Masahiro; Abe, Masaaki; Hino, Okio
Malignant mesothelioma is a highly aggressive tumor of the serosal cavity that arises from the mesothelial cells of the pleura, peritoneum, or pericardium. The immunohistochemical diagnosis of epithelioid mesothelioma from biopsy or surgically resected specimens has been actively pursued, using markers such as mesothelin. Several markers have indeed been helpful for confirming the diagnosis of mesothelioma and distinguishing between mesothelioma and adenocarcinoma. The authors have developed a novel mAb to human C-ERC/mesothelin, which performed well when used in western blotting, fluorescence-activated cell sorting, immunocytochemistry and immunohistochemistry, and which therefore will be useful in studying the molecular biology of mesothelin, in addition to improving the diagnosis and therapy of mesothelin-expressing cancers.
The Dosimetry Service
We have observed a significant decrease in the number of completed Certificates for Work in Controlled Radiation Areas being submitted with applications for dosimeters for your staff. Henceforth, we shall no longer be able to issue dosimeters without a certificate, which must be signed by the employee and the contractor's radiation-protection expert. You can obtain the certificate form from the Dosimetry Service at Building 24/E-011 or from our Website: http://service-rp-dosimetry.web.cern.ch/service-rp-dosimetry/. Thank you for your understanding. The Dosimetry Service
Smith, J.R.; Kidwell, C.K.; Unger, V.E.; Fercho, E.; Helmer, C.M.
In May 1988, Shell Western E and P Inc. (SWEPI) and partners Elf Aquitaine Petroleum and Conoco Inc. signed a letter of intent with Canadian Marine Drilling Ltd. (Canmar) for provision of exploratory drilling and marine services on leases in OCS Lease Sale 109 in the Chukchi Sea, Alaska. The 5450 blocks offered in the remote sale area west of Point Barrow ranged from 3 to 240 miles (5 to 380 km) offshore in water depths from 26 to 263 feet (8 to 80 m). The principal interest tracts were at least 75 miles (120 km) offshore and north of 70 degrees N latitude. The remoteness and total lack of any oilfield infrastructure required considerable planning and coordination between Operator and Contractor in order to carry out the three-year drilling program efficiently and safely in an environmentally harsh and, at the same time, sensitive area. SWEPI and Canmar developed a close working relationship from the start of the project through a number of participative approaches to the problems that had to be solved. This paper reports that these included strong reliance on operational planning meetings, post-season analyses, and an overall emphasis on the teamwork required of both parties to carry out the first-ever drilling program in the Chukchi Sea. This approach led to a very successful operation for both parties and emphasizes the positive benefits achievable when Operator and Contractor work as a team
Walraven, A.R.; Vries, de B.
The procurement of a construction contractor should consider more aspects than only cost or price. Taking value and price into account to select the ‘best value for money’ bid results in adopting a structured multicriteria approach. An alternative contractor selection method is presented, which
McDonald, Catherine H; Heggie, James; Jones, Christopher M; Thorne, Christopher J; Hulme, Jonathan
Updated life-support guidelines were published by the European Resuscitation Council (ERC) in 2010, increasing the required depth and rate of chest compression delivery. This study sought to determine the impact of these guidelines on rescuer fatigue and cardiopulmonary resuscitation (CPR) performance. 62 Health science students performed 5 min of conventional CPR in accordance with the 2010 ERC guidelines. A SkillReporter manikin was used to objectively assess temporal change in determinants of CPR quality. Participants subjectively reported their end-fatigue levels, using a visual analogue scale, and the point at which they believed fatigue was affecting CPR delivery. 49 (79%) participants reported that fatigue affected their CPR performance, at an average of 167 s. End fatigue averaged 49.5/100 (range 0-95). The proportion of chest compressions delivered correctly decreased from 52% in min 1 to 39% in min 5, approaching significance (p=0.071). A significant decline in chest compressions reaching the recommended depth occurred between the first (53%) and fifth (38%) min (p=0.012). Almost half this decline (6%) was between the first and second minutes of CPR. Neither chest compression rate, nor rescue breath volume, were affected by rescuer fatigue. Fatigue affects chest compression delivery within the second minute of CPR under the 2010 ERC guidelines, and is poorly judged by rescuers. Rescuers should, therefore, be encouraged to interchange after 2 min of CPR delivery. Team leaders should be advised to not rely on rescuers to self-report fatigue, and should, instead, monitor for its effects.
Schiffbaenker, H.; Holzinger, F.
Scientific excellence is of increasing relevance for assessing and funding research. Yet the definition of excellence is unclear and excellence difficult to measure. Classical indicators like scientific outcome and impact have been identified to have various limitations, in particular from a gender perspective. So other indicators are applied, like independence. In this paper we discuss various aspects of applying independence as indicator for excellence in ERC peer review panels. In core we analyse how independence is formally defined and how it is applied in practice, with focus on its gendered effects. Further, potential and limitations of independence as criterion for excellence are discussed. (Author)
Heer, H.; Furrer, A.; Walker, E.
Inelastic neutron scattering experiments and susceptibility measurements have been carried out on polycrystalline ErcY1-cAl2. A least-squares fitting procedure has been applied to the neutron data which favours four sets of crystal-field parameters. The results are compared with the measured...... susceptibility and other bulk magnetic properties. From this it is concluded that the crystal-field parameters x=-0.54 and W=-0.018 meV are the most probable ones....
Jones Christopher M
Full Text Available Abstract Introduction Effective delivery of cardiopulmonary resuscitation (CPR and prompt defibrillation following sudden cardiac arrest (SCA is vital. Updated guidelines for adult basic life support (BLS were published in 2010 by the European Resuscitation Council (ERC in an effort to improve survival following SCA. There has been little assessment of the ability of rescuers to meet the standards outlined within these new guidelines. Methods We conducted a retrospective analysis of the performance of first year healthcare students trained and assessed using either the new 2010 ERC guidelines or their 2005 predecessor, within the University of Birmingham, United Kingdom. All students were trained as lay rescuers during a standardised eight hour ERC-accredited adult BLS course. Results We analysed the examination records of 1091 students. Of these, 561 were trained and assessed using the old 2005 ERC guidelines and 530 using the new 2010 guidelines. A significantly greater proportion of candidates failed in the new guideline group (16.04% vs. 11.05%; p Conclusions The new ERC guidelines lead to a greater proportion of lay rescuers performing chest compressions at an erroneously fast rate and may therefore worsen BLS efficacy. Additional study is required in order to define the clinical impact of compressions performed to a greater depth and at too fast a rate.
Hill, Nathan E
.... There is undoubtedly a need for military contractors and there are numerous positive arguments in their favor. However, the negative arguments have not been highlighted enough recently and the scales are now out of balance. The intent of this research paper is to encourage the U.S. military to rebalance the scales and curb the over-reliance on contractors.
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor responsibility. 1845.502 Section 1845.502 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... Contractors 1845.502 Contractor responsibility. ...
Full Text Available Considerando a importância do desenvolvimento do relacionamento entre as empresas e seus clientes, este trabalho tem por objetivo validar um instrumento científico capaz de mensurar tal relacionamento, destacando a satisfação e a lealdade como pressupostos para a sua construção e manutenção. A pesquisa, de natureza quantitativa, utilizou-se de Análise Fatorial Exploratória para a validação experimental do instrumento e de uma amostra de 627 clientes de diversas empresas. Os resultados encontrados mostram que a Escala de Relacionamento com o Cliente (ERC possui uma estrutura unifatorial, explicando cerca de 64% da variância e com confiabilidade de 0,92 (α de Cronbach. O trabalho contribui com a produção científica nas áreas de marketing e afins, uma vez que a ERC pode ser utilizada em estudos diagnósticos e relacionais. Ademais, a contribuição do estudo estende-se à área organizacional, visto que o instrumento pode auxiliar gestores no sentido de incrementar o relacionamento que desenvolvem com seus clientes e melhorar os resultados organizacionais.
Roehr, C C; Hansmann, G; Hoehn, T; Bührer, C
In 2010, the American Heart Association (AHA), the European Resuscitation Council (ERC) and the International Liaison Committee on Resuscitation (ILCOR) issued new guidelines on newborn resuscitation. The new recommendations include: (1) pulse-oximetry for patient assessment during newborn resuscitation; (2) to start resuscitation of term infants with an FiO (2) of 0.21; (3) cardio-respiratory resuscitation with a 3:1 chest compression/inflation ratio for a heart rate ERC and ILCOR used nearly identical literature for their evidence evaluation process. While the AHA and ILCOR guidelines are almost identical, the ERC guidelines differ slightly from the latter with regards to (i) promoting sustained inflations at birth, (ii) promoting a wider range in applied inflations during resuscitation, and (iii) to suction the airways in infants born from meconium stained amniotic fluid, before inflations are given. © Georg Thieme Verlag KG Stuttgart · New York.
Thorne, Christopher J; Jones, Christopher M; Harvey, Philip; Hulme, Jonathan; Owen, Andrew
Existing ERC BLS/AED accreditation procedures allow BLS instructors to assess the capability of BLS/AED providers, without undergoing additional training as an assessor. The reliability of instructor-based assessment has been questioned. This study sought to determine the efficacy of a simple training programme for BLS/AED instructors aimed at standardising assessment decisions. An Assessment Training Programme (ATP) which provides additional, assessment-focused tuition for BLS instructors was introduced. Eighteen ERC accredited instructors participated in the study. Nine received standard ERC training (instructors); nine received additional training through the ATP (assessors). The assessment of 73 students' BLS/AED capabilities was carried out by an assessor, ERC instructor and ERC instructor trainer concurrently. Participants independently completed an ERC assessment form. Decisions for instructors and assessors were compared to the instructor trainers' decisions; those not agreeing were deemed to be incorrect. Instructors (49.3%) had lower raw pass rates than assessors (67.1%) and instructor trainers (64.4%). There was a significant difference in overall decisions between instructors and instructor trainers (p=0.035), and instructors and assessors (p=0.015). There was no difference between assessors and instructor trainers (p=0.824). Instructors were more prone to incorrectly failing candidates than assessors (sensitivities of 80.5% and 63.8% respectively, p=0.077). AED-capability decisions were significantly different from instructor trainers in both the instructor (p=0.007) and assessor groups (p=0.031). BLS instructors incorrectly fail candidates for reasons that should not normally constitute a true assessment failure. The ATP is an effective intervention to reduce false-failure rates and improve compliance with an experienced instructor trainer's decision. Consideration should be made to integrate such programmes into current BLS instructor accreditation
Unlike the general contractor approach, the construction management firm acts on behalf of the school district in school construction. Examines the development and nature of construction management, and cites its advantages and disadvantages. (MLF)
Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Dataset includes grant, project, and contractor awarded which are tracked for ensuring Davis-Bacon Act compliance where applicable. The 1931 Davis-Bacon Act...
U.S. Department of Health & Human Services — The Centers for Medicare and Medicaid Services (CMS) has compiled a summary of overall Medicare Administrative Contractor (MAC) performance information as measured...
Moses, O. Douglas
This paper investigates pricing strategies used by major defense contractors. Two pricing strategies are identified and discussed: penetration, which calls for a relatively low initial price followed by little reduction in price over time, and skimming, which calls for a relatively high initial price coupled with greater reduction in price over time. It is argued that contractor pricing strategy will depend on features of the defense program under consideration and featur...
Lacaria, Chris J.
The scope of this paper is to discuss the financial management of a construction contractor. This paper attempts to approach this subject in a logical and systematic way. It communicates the importance of financial analysis and planning along with cash planning and profit planning. This report is not intended to be an all inclusive discussion of financial management in construction. Contractor's Financial Management is an extremely important subject. It has been told ...
Hansen, H.H.; Toftgaard, C.; Rokkjor, M.J.; Kruse, A.; Funch-Jensen, P.; Thommesen, P.; Municipal Hospital, Aarhus
Cholescintigraphy after food stimulation was carried out in 40 patients (13 patients with biliary enteric bypass, 14 patients with bile duct stenosis, demonstrated by ERC, 5 patients with endoprothesis and 8 patients with clinically suspected post-cholecystectomy syndrome). Biliary-bowel transit time of one hour or less was considered to be normal. It is concluded that in patients with biliary enteric bypass (hepatico-jejunostomia) or biliary strictures a biliary-bowel transit time of one hour will be discriminatory between normal and abnormal conditions. This is in contrast to patients with endoprothesis and suspected sphincter of Oddi dysmotility, where a transit time of one hour only will have limited predictive value. (orig.) [de
...] Contractor Performance Information AGENCY: Environmental Protection Agency (EPA), ACTION: Direct final rule... contractor performance information. EPA is issuing a final rule because the changes are procedural in nature... Institutes of Health's Contractor Performance System (CPS) to the Department of Defense's Contractor...
... 49 Transportation 3 2010-10-01 2010-10-01 false Contractor employees. 199.115 Section 199.115... § 199.115 Contractor employees. With respect to those employees who are contractors or employed by a contractor, an operator may provide by contract that the drug testing, education, and training required by...
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contractor... CONTRACT MANAGEMENT QUALITY ASSURANCE General 46.105 Contractor responsibilities. (a) The contractor is..., and furnishing such information to the Government as required. (b) The contractor may be required to...
... 49 Transportation 3 2010-10-01 2010-10-01 false Contractor employees. 199.245 Section 199.245... Prevention Program § 199.245 Contractor employees. (a) With respect to those covered employees who are contractors or employed by a contractor, an operator may provide by contract that the alcohol testing...
... 7 Agriculture 11 2010-01-01 2010-01-01 false Contractor's bonds. 1726.27 Section 1726.27... AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES General § 1726.27 Contractor's bonds. (a) RUS Form 168b, Contractor's Bond, shall be used when a contractor's bond is required by RUS Forms 200, 257...
Sato, Tadashi; Suzuki, Yohei; Mori, Takanori; Maeda, Masahiro; Abe, Masaaki; Hino, Okio; Takahashi, Kazuhisa
Pleural mesothelioma is an aggressive tumor, commonly caused by exposure to asbestos. The prognosis of mesothelioma remains disappointing despite multimodal treatment. We reported previously that N-ERC/mesothelin could be a useful biomarker for the early diagnosis of pleural mesothelioma and developed an enzyme-linked immunosorbent assay (ELISA) system for its detection. However, the reproducibility of our previous 7-16 ELISA system has been revealed to be unsatisfactory. To measure N-ERC/mesothelin more precisely, we developed a new 7-20 ELISA system. The subjects of this study were patients who were referred to our department with suspected pleural mesothelioma. The current study demonstrated that the newly established 7-20 ELISA system improved the sensitivity and specificity for diagnosing pleural mesothelioma compared with the previous system. Moreover, the 7-20 ELISA system showed better reproducibility and displayed the tendency of both higher sensitivity and higher specificity in plasma than in serum. Particularly for the epithelioid type, the area under the curve (AUC) and the diagnostic accuracy of N-ERC/mesothelin were excellent; the AUC was 0.91, the sensitivity was 0.95, and the specificity was 0.76 in plasma. In conclusion, assessment of N-ERC/mesothelin with our newly established 7-20 ELISA system is clinically useful for the precise diagnosis of pleural mesothelioma. © 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Owen, Andrew; Kocierz, Laura; Aggarwal, Naresh; Hulme, Jonathan
The importance of immediate cardiopulmonary resuscitation (CPR) and defibrillation after cardiac arrest is established. The 2005 European Resuscitation Council (ERC) guidelines were altered to try to improve survival after cardiac arrest. This observational study compares the errors in basic life support (BLS) performance after training using the 2000 or 2005 guidelines. First-year healthcare students at the University of Birmingham, United Kingdom, were taught adult BLS in a standardised 8-h course: an historical group with previous ERC guidelines (Old), the other with 2005 ERC guidelines (New). 2537 (Old 1773; New 764) students were trained and assessed in BLS. There was no difference in overall error rate between Old and New (5.53% vs. 6.70% (p>0.05)) or adherence to the sequence of the respective BLS algorithm. The New group ("hands in centre of the chest") had significantly more erroneous hand positions compared to the Old group (5.23% vs. 1.64%, pERC guidelines do not significantly improve correct BLS performance. Removal of hand placement measurement results in a significant increase in hand position errors. The clinical benefit of an increased number of compressions impaired by worsened hand positioning is unknown and requires further study. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
... direct contractor (Spain). 252.229-7004 Section 252.229-7004 Federal Acquisition Regulations System... contractor (Spain). As prescribed in 229.402-70(d), use the following clause: Status of Contractor as a Director Contractor (Spain) (JUN 1997) (a) “Direct Contractor,” as used in this clause, means an individual...
Jones, Christopher M; Owen, Andrew; Thorne, Christopher J; Hulme, Jonathan
Effective delivery of cardiopulmonary resuscitation (CPR) and prompt defibrillation following sudden cardiac arrest (SCA) is vital. Updated guidelines for adult basic life support (BLS) were published in 2010 by the European Resuscitation Council (ERC) in an effort to improve survival following SCA. There has been little assessment of the ability of rescuers to meet the standards outlined within these new guidelines. We conducted a retrospective analysis of the performance of first year healthcare students trained and assessed using either the new 2010 ERC guidelines or their 2005 predecessor, within the University of Birmingham, United Kingdom. All students were trained as lay rescuers during a standardised eight hour ERC-accredited adult BLS course. We analysed the examination records of 1091 students. Of these, 561 were trained and assessed using the old 2005 ERC guidelines and 530 using the new 2010 guidelines. A significantly greater proportion of candidates failed in the new guideline group (16.04% vs. 11.05%; p < 0.05), reflecting a significantly greater proportion of lay-rescuers performing chest compressions at too fast a rate when trained and assessed with the 2010 rather than 2005 guidelines (6.04% vs. 2.67%; p < 0.05). Error rates for other skills did not differ between guideline groups. The new ERC guidelines lead to a greater proportion of lay rescuers performing chest compressions at an erroneously fast rate and may therefore worsen BLS efficacy. Additional study is required in order to define the clinical impact of compressions performed to a greater depth and at too fast a rate.
Chen, Lu; Lu, Yi; Wu, Jia-Chuan; Bie, Like; Xia, Lu; Gong, Biao
Accurately differentiating malignant diseases from benign ones in patients having bile duct obstruction is of significant importance and remains a major clinical problem. This study investigated the diagnostic yield of endoscopic retrograde cholangiography/intraductal ultrasound (ERC/IDUS) in distinguishing malignant from benign bile duct obstruction and assessed some image findings from ERC/IDUS which might be useful in differentiation. From January 2008 to January 2015, patients who underwent ERC/IDUS for bile duct obstruction were enrolled. Patient's ERC/IDUS diagnosis was compared with the final diagnosis determined by pathologic findings and/or clinical outcome of follow-up. One hundred and ninety-three patients with bile duct obstruction were included. IDUS correctly identified 94 of 97 malignant diseases and 76 of 96 benign diseases with sensitivity, specificity, and accuracy rate of 96.91, 79.17, and 88.08 %, respectively. Additionally, the accuracy rate of IDUS for diagnosis of proximal bile duct obstruction was higher than that of distal bile duct obstruction (98.08 vs. 82.73 %, p = 0.006). Besides, there was a significant difference in the length at the obstruction site between benign and malignant diseases (13.76 ± 7.37 vs. 19.97 ± 11.37 mm, p 7 mm without extrinsic compression had a positive predictive value (PPV) of 100 % for including malignancy, while length ≧20 mm demonstrated a PPV of 93.44 %. ERC/IDUS is effective in distinguishing malignant from benign bile duct obstruction, thus helping in further clinical management.
Yoshida, Chisato; Sogawa, Chizuru; Tsuji, Atsushi B; Sudo, Hitomi; Sugyo, Aya; Uehara, Tomoya; Hino, Okio; Yoshii, Yukie; Fujibayashi, Yasuhisa; Fukumura, Toshimitsu; Koizumi, Mitsuru; Arano, Yasushi; Saga, Tsuneo
Malignant mesothelioma is a highly aggressive form of cancer. Curative surgery is the only effective therapy for mesothelioma, and therefore early diagnosis is important. However, early diagnosis is difficult using current diagnostic imaging techniques, and a new imaging method for early diagnosis is urgently required. We evaluated the affinity of radiolabeled monoclonal antibodies to the C-terminal fragment of ERC/mesothelin for this purpose. In-labeled or I-labeled IgG against C-terminal fragment of ERC and its Fab fragment were evaluated in vitro by cell binding, competitive inhibition, and cellular internalization assays, and in vivo by biodistribution in mice bearing ERC-expressing tumors. Next, the Fab fragment was labeled with the positron emitter Cu and evaluated by positron emission tomography (PET). Radiolabeled IgG and Fab showed specific binding to ERC-expressing mesothelioma cells with high affinity. Both radiolabeled IgG and Fab internalized into cells after binding to ERC on the cell surface. In-labeled IgG accumulated in ERC-expressing tumors and resulted in a moderate tumor-to-blood ratio at 4 days after injection. Furthermore, PET using Cu-labeled Fab visualized the tumor at 6 h after injection. Cu-labeled Fab can be useful for ERC-specific PET imaging, and can thus facilitate improved diagnosis of patients with early-stage mesothelioma.
This article argues that the role of Private Security Contractors in Darfur reflects and reinforces neo-liberal governmentality in contemporary security governance. It is an argument (in line with other articles in this special issue) which is more interested in discussing how the privatization....... It underlines that governance is increasingly taking place through a set of (quasi-) markets, it is marked by entrepreneurial values, and a hands off approach to governance. We then discuss the way this overall change is reflected in and reinforced by the role of private security contractors in Darfur. Drawing...... at these processes is necessary to understand the role of private security contractors in Darfur. But more than this, practices in Darfur entrench neo-liberal governmentality in security more generally. The managerial and `de-politicizing' approach to security in Darfur displaces alternative views not only...
Full Text Available The State contract is one of the most important tools for public management. The formation, execution and liquidation of State contracts are also a potential cause of State patrimonial damages. Perhaps for this reason, many State contractors are prosecuted as if they were public spending managers. The question, however, is not as simple. The fiscal liability process has a qualified recipient: the fiscal manager. In this article, through a conceptual exposition and a case study, we identify the criterion for determining in which cases a State contractor acquires the function of controlling public funds and when he/she can be subjected to a fiscal liability.
In Private Military and Security Contractors: Controlling the Corporate Warrior a multinational team of 16 scholars and a practitioner from political science, sociology, and law address a developing phenomenon: controlling the use of privatized force by states in international politics. Robust...
... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 209 Contractor Qualifications CFR Correction In Title 48 of the Code of Federal Regulations, Chapter 2 (Parts 201-299), revised as of October 1, 2011, on page 55, in section 209.104-70, paragraph (a) is amended by revising the...
promotes integrity, physical strength, health, unity, cooperation and teamwork. It combats stereotyping and sexual harassment. It fosters in its...weeklyreport108-000001337290&type= toc &num=115&; accessed 15 Jan 2008. 20 U.S. Department of the Army, Contractors on the Battlefield, Field Manual 3
John, Alka Rachel; Manivannan, M; Ramakrishnan, T V
As per the AHA 2015 and ERC 2015 guidelines for resuscitation, chest compression depth should be between 5 and 6 cm with a rate of 100-120 compressions per minute. Theoretical validation of these guidelines is still elusive. We developed a computer model of the cardiopulmonary resuscitation (CPR) system to validate these guidelines. A lumped element computer model of the cardiovascular system was developed to simulate cardiac arrest and CPR. Cardiac output was compared for a range of compression pressures and frequencies. It was observed from our investigation that there is an optimum compression pressure and rate. The maximum cardiac output occurred at 100 mmHg, which is approximately 5.7 cm, and in the range of 100 to 120 compressions per minute with an optimum value at 110 compressions per minute, validating the guidelines. Increasing the pressure or the depth of compression beyond the optimum, limits the blood flow by depleting the volume in the cardiac chambers and not allowing for an effective stroke volume. Similarly increasing the compression rate beyond the optimum degrades the ability of the chambers to pump blood. The results also bring out the importance of complete recoil of the chest after each compression with more than 400% increase in cardiac output from 90% recoil to 100% recoil. Our simulation predicts that the recommendation to compress harder and faster is not the best counsel as there is an optimum compression pressure and rate for high-quality CPR.
Equal opportunities is still regarded a "women's issue" by many. Implicit to this notion is the assumption that men are made to work and make a career. However, if we agree that life consists of more than work and sleep, and if we agree that men have the right to be with their children, equal opportunities are of course equally important for men: it means to provide opportunities for men to spend time with their families and children. In this presentation, I would like to share my personal experience as ERC grantee, father of three children, and husband of a scientist. I will highlight the importance of personal choices, but also of policies and institutional structures that promote or impede equal opportunities for men. I will make the point that providing opportunities for men to be with their children, while they pursue an academic career, will be beneficial not only for them, but also for women, and therefore constitutes a key component in work towards equal opportunities.
Vîlceanu, Fl; Iancu, C.
The existence of bucket wheel equipment type ERC 1400-30/7 in lignite quarries with lifetime expired, or in the ultimate life period, together with high cost investments for their replacement, makes rational the efforts made to rehabilitation in order to extend their life. Rehabilitation involves checking operational safety based on relevant expertise of metal structures supporting effective resistance but also the replacement (or modernization) of subassemblies that can increase excavation process productivity, lowering energy consumption, reducing mechanical stresses. This paper proposes an analysis of constructive solution of using a part of the classical bucket wheel, on which are located 9 cutting cups and 9 chargers cups and adding a new part so that the new redesigned bucket-wheel will contain 18 cutting-chargers cups, compared to the classical model. On the CAD model of bucket wheel was performed a static and a dynamic FEA, the results being compared with the yield strength of the material of the entire structure, were checked mechanical stresses in the overall distribution map, and were verified the first 4 vibrating modes the structure compared to real loads. Thus was verified that the redesigned bucket-wheel can accomplish the proposed goals respectively increase excavation process productivity, lowering energy consumption and reducing mechanical stresses.
Stojkovic, Marija; Junghanss, Thomas; Veeser, Mira; Weber, Tim F.; Sauer, Peter
Background and Aims Biliary vessel pathology due to alveolar echicococcosis (AE) results in variable combinations of stenosis, necrosis and inflammation. Modern management strategies for patients with cholestasis are desperately needed. The aim is proof of principle of serial ERC (endoscopic retrograde cholangiography) balloon dilation for AE biliary pathology. Methods Retrospective case series of seven consecutive patients with AE-associated biliary pathology and ERC treatment in an interdisciplinary endoscopy unit at a University Hospital which hosts a national echinococcosis treatment center. The AE patient cohort consists of 106 patients with AE of the liver of which 13 presented with cholestasis. 6/13 received bilio-digestive anastomosis and 7/13 patients were treated by ERC and are reported here. Biliary stricture balloon dilation was performed with 18-Fr balloons at the initial and with 24-Fr balloons at subsequent interventions. If indicated 10 Fr plastic stents were placed. Results Six patients were treated by repeated balloon dilation and stenting, one by stenting only. After an acute phase of 6 months with repeated balloon dilation, three patients showed “sustained clinical success” and four patients “assisted therapeutic success,” of which one has not yet reached the six month endpoint. In one patient, sustained success could not be achieved despite repeated insertion of plastic stents and balloon dilation, but with temporary insertion of a fully covered self-expanding metal stent (FCSEMS). There was no loss to follow up. No major complications were observed. Conclusions Serial endoscopic dilation is a standard tool in the treatment of benign biliary strictures. Serial endoscopic intervention with balloon dilation combined with benzimidazole treatment can re-establish and maintain biliary duct patency in AE associated pathology and probably contributes to avoid or postpone bilio-digestive anastomosis. This approach is in accordance with current
Full Text Available Biliary vessel pathology due to alveolar echicococcosis (AE results in variable combinations of stenosis, necrosis and inflammation. Modern management strategies for patients with cholestasis are desperately needed. The aim is proof of principle of serial ERC (endoscopic retrograde cholangiography balloon dilation for AE biliary pathology.Retrospective case series of seven consecutive patients with AE-associated biliary pathology and ERC treatment in an interdisciplinary endoscopy unit at a University Hospital which hosts a national echinococcosis treatment center. The AE patient cohort consists of 106 patients with AE of the liver of which 13 presented with cholestasis. 6/13 received bilio-digestive anastomosis and 7/13 patients were treated by ERC and are reported here. Biliary stricture balloon dilation was performed with 18-Fr balloons at the initial and with 24-Fr balloons at subsequent interventions. If indicated 10 Fr plastic stents were placed.Six patients were treated by repeated balloon dilation and stenting, one by stenting only. After an acute phase of 6 months with repeated balloon dilation, three patients showed "sustained clinical success" and four patients "assisted therapeutic success," of which one has not yet reached the six month endpoint. In one patient, sustained success could not be achieved despite repeated insertion of plastic stents and balloon dilation, but with temporary insertion of a fully covered self-expanding metal stent (FCSEMS. There was no loss to follow up. No major complications were observed.Serial endoscopic dilation is a standard tool in the treatment of benign biliary strictures. Serial endoscopic intervention with balloon dilation combined with benzimidazole treatment can re-establish and maintain biliary duct patency in AE associated pathology and probably contributes to avoid or postpone bilio-digestive anastomosis. This approach is in accordance with current ERC guidelines and is minimally disruptive
Stojkovic, Marija; Junghanss, Thomas; Veeser, Mira; Weber, Tim F; Sauer, Peter
Biliary vessel pathology due to alveolar echicococcosis (AE) results in variable combinations of stenosis, necrosis and inflammation. Modern management strategies for patients with cholestasis are desperately needed. The aim is proof of principle of serial ERC (endoscopic retrograde cholangiography) balloon dilation for AE biliary pathology. Retrospective case series of seven consecutive patients with AE-associated biliary pathology and ERC treatment in an interdisciplinary endoscopy unit at a University Hospital which hosts a national echinococcosis treatment center. The AE patient cohort consists of 106 patients with AE of the liver of which 13 presented with cholestasis. 6/13 received bilio-digestive anastomosis and 7/13 patients were treated by ERC and are reported here. Biliary stricture balloon dilation was performed with 18-Fr balloons at the initial and with 24-Fr balloons at subsequent interventions. If indicated 10 Fr plastic stents were placed. Six patients were treated by repeated balloon dilation and stenting, one by stenting only. After an acute phase of 6 months with repeated balloon dilation, three patients showed "sustained clinical success" and four patients "assisted therapeutic success," of which one has not yet reached the six month endpoint. In one patient, sustained success could not be achieved despite repeated insertion of plastic stents and balloon dilation, but with temporary insertion of a fully covered self-expanding metal stent (FCSEMS). There was no loss to follow up. No major complications were observed. Serial endoscopic dilation is a standard tool in the treatment of benign biliary strictures. Serial endoscopic intervention with balloon dilation combined with benzimidazole treatment can re-establish and maintain biliary duct patency in AE associated pathology and probably contributes to avoid or postpone bilio-digestive anastomosis. This approach is in accordance with current ERC guidelines and is minimally disruptive for patients.
Meenakshisundaram, V.; Rajagopal, V.; Mathiyarasu, R.; Subramanian, V.; Rajaram, S.; Somayaji, K.M.; Kannan, V.; Rajagopalan, H.
In India, Department of Atomic Energy (DAE) has been identified as the nodal agency/authority in respect of providing the necessary technical inputs in the event of any radiation emergency that may occur in public domain. The overall system takes into consideration statutory requirements, executive decisions as well as National and International obligations. This paper highlights the details about the strength of the Kalpakkam ERC and other essential requisites and their compliance since its formation
Sakamoto, Yoshimitsu; Dai, Nakae; Hagiwara, Yoshiaki; Satoh, Kanako; Ohashi, Norio; Fukamachi, Katsumi; Tsuda, Hiroyuki; Hirose, Akihiko; Nishimura, Tetsuji; Hino, Okio; Ogata, Akio
Expressed in renal carcinoma (ERC)/mesothelin is a good biomarker for human mesothelioma and has been investigated for its mechanistic rationale during the mesothelioma development. Studies are thus ongoing in our laboratories to assess expression of ERC/mesothelin in sera and normal/proliferative/neoplastic mesothelial tissues of animals untreated or given potentially mesothelioma-inducible xenobiotics, by an enzyme-linked immunosorbent assay (ELISA) for N- and C-(terminal fragments of) ERC/mesothelin and immunohistochemistry for C-ERC/mesothelin. In the present paper, we intend to communicate our preliminary data, because this is the first report to show how and from what stage the ERC/mesothelin expression changes during the chemical induction of mesothelial proliferative/neoplatic lesions. Serum N-ERC/mesothelin levels were 51.4 +/- 5.6 ng/ml in control male Fischer 344 rats, increased to 83.6 +/- 11.2 ng/ml in rats given a single intrascrotal administration of 1 mg/kg body weight of multi-wall carbon nanotube (MWCNT) and bearing mesothelial hyperplasia 52 weeks thereafter, and further elevated to 180 +/- 77 ng/ml in rats similarly treated and becoming moribund 40 weeks thereafter, or killed as scheduled at the end of week 52, bearing mesothelioma. While C-ERC/mesothelin was expressed in normal and hyperplastic mesothelia, the protein was detected only in epithelioid mesothelioma cells at the most superficial layer. It is thus suggested that ERC/mesothelin can be used as a biomarker of mesothelial proliferative lesions also in animals, and that the increase of levels may start from the early stage and be enhanced by the progression of the mesothelioma development.
... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System Policy on Contractor Profits AGENCY... Authorization Act for Fiscal Year 2013. Section 804, Department of Defense Policy on Contractor Profits... modifications to such guidelines that are necessary to ensure an appropriate link between contractor profit and...
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contractor employees. 725... SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Source, Origin, and Nationality 725.703 Contractor employees. (a... on employees or consultants of either contractors or subcontractors providing services under an USAID...
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor certification... EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 1609.471 Contractor certification. All FEHBP carriers and applicant carriers...
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contractor certification... CONTRACTING REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Disputes and Appeals 33.207 Contractor certification. (a) Contractors shall provide the certification specified in paragraph (c) of this section when...
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor. 1602.170-4 Section 1602.170-4 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES... 1602.170-4 Contractor. Contractor means carrier. ...
... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Contractor claims. 35.6600 Section 35... Actions Procurement Requirements Under A Cooperative Agreement § 35.6600 Contractor claims. (a) General... prepared by the contractor to support a claim against the recipient; and (4) The award official determines...
Moreels, Tom G; Pelckmans, Paul A
To compare the efficacy of double-balloon enteroscopy (DBE) and single-balloon enteroscopy (SBE) in therapeutic endoscopic retrograde cholangiography (ERC) in patients with Roux-en-Y entero-enteric anastomosis. Retrospective analysis of our patient cohort revealed 4 patients with enterobiliary anastomosis and Roux-en-Y entero-enteric anastomosis who underwent repeated ERC with DBE and SBE because of recurrent cholangitis. A total of 38 endoscopic retrograde cholangiopancreatography procedures were performed in 25 patients with Roux-en-Y entero-enteric anastomosis. DBE was used in 29 procedures and SBE in 9. The 4 patients who underwent repeated ERC with DBE and SBE suffered from recurrent cholangitis due to stenosis of the enterobiliary anastomosis. ERC was performed repeatedly to achieve balloon dilation with/without biliary stone extraction and multiple stent placement at the level of the enterobiliary anastomosis. In all 4 patients DBE and SBE were equally successful. Compared to DBE, SBE was equally effective in passing the Roux-en-Y entero-enteric anastomosis, reaching the enterobiliary anastomosis and performing therapeutic ERC. This retrospective comparison shows that DBE and SBE are equally successful in the performance of therapeutic ERC at the level of the enterobiliary anastomosis after Roux-en-Y entero-enteric anastomosis.
Jäntti, H; Kuisma, M; Uusaro, A
The European Resuscitation Council (ERC) guidelines changed in 2005. We investigated the impact of these changes on no flow time and on the quality of cardiopulmonary resuscitation (CPR). Simulated cardiac arrest (CA) scenarios were managed randomly in manikins using ERC 2000 or 2005 guidelines. Pairs of paramedics/paramedic students treated 34 scenarios with 10min of continuous ventricular fibrillation. The rhythm was analysed and defibrillation shocks were delivered with a semi-automatic defibrillator, and breathing was assisted with a bag-valve-mask; no intravenous medication was given. Time factors related to human intervention and time factors related to device, rhythm analysis, charging and defibrillation were analysed for their contribution to no flow time (time without chest compression). Chest compression quality was also analysed. No flow time (mean+/-S.D.) was 66+/-3% of CA time with ERC 2000 and 32+/-4% with ERC 2005 guidelines (PERC 2000) versus 107+/-4s (ERC 2005) during 600-s scenarios (P=0.237). Device factor interventions took longer using ERC 2000 guidelines: 290+/-19s versus 92+/-15s (PERC 2005 guidelines (808+/-92s versus 458+/-90s, P<0.001), but the quality of CPR did not differ between the groups. The use of a single shock sequence with guidelines 2005 has decreased the no flow time during CPR when compared with guidelines 2000 with multiple shocks.
Hempel, Niels; Görisch, Helmut; Mern, Demissew S
Several two-component regulatory systems are known to be involved in the signal transduction pathway of the ethanol oxidation system in Pseudomonas aeruginosa ATCC 17933. These sensor kinases and response regulators are organized in a hierarchical manner. In addition, a cytoplasmic putative iron-containing alcohol dehydrogenase (Fe-ADH) encoded by ercA (PA1991) has been identified to play an essential role in this regulatory network. The gene ercA (PA1991) is located next to ercS, which encodes a sensor kinase. Inactivation of ercA (PA1991) by insertion of a kanamycin resistance cassette created mutant NH1. NH1 showed poor growth on various alcohols. On ethanol, NH1 grew only with an extremely extended lag phase. During the induction period on ethanol, transcription of structural genes exa and pqqABCDEH, encoding components of initial ethanol oxidation in P. aeruginosa, was drastically reduced in NH1, which indicates the regulatory function of ercA (PA1991). However, transcription in the extremely delayed logarithmic growth phase was comparable to that in the wild type. To date, the involvement of an Fe-ADH in signal transduction processes has not been reported.
Sandroni, C; Nolan, J
The new European Resuscitation Council (ERC) guidelines for cardiopulmonary resuscitation (CPR) published on October 18th, 2010, replace those published in 2005 and are based on the latest International Consensus on CPR Science with Treatment Recommendations (CoSTR). For both adult and pediatric resuscitation, the most important general changes include: the introduction of chest compression-only CPR in primary cardiac arrest as an option for rescuers who are unable or unwilling to perform expired-air ventilation; increased emphasis on uninterrupted, good-quality CPR and minimisation of both pre- and post-shock pauses during defibrillation. For adult resuscitation, the recommended chest compression depth and rate are 5-6 cm and 100-120 compressions per minute, respectively. Both a specific period of CPR before defibrillation during out-of-hospital resuscitation and use of endotracheal route for drug delivery during advanced life support are no longer recommended. During postresuscitation care, inspired oxygen should be titrated to obtain an arterial oxygen saturation of 94-98%, to avoid possible damage from hyperoxemia. In pediatric resuscitation, the role of pulse palpation for the diagnosis of cardiac arrest has been de-emphasised. The compression-to-ventilation ratio depends on the number of rescuers available, and a 30:2 ratio is acceptable even for rescuers with a duty to respond if they are alone. Chest compression depth should be at least 1/3 of the anterior-posterior chest diameter. The use of automated external defibrillators for children under one year of age should be considered.
This report presents the general management structure of the Technical Assistance Contractor (TAC) for the Uranium Mill Tailings Remedial Action (UMTRA) Project. This team is a partnership of four major private subcontractors, which teamed together, are striving to be the leader in environmental restoration of uranium mining and milling operations. It will provide a pool of experts in various aspects of the technologies necessary to accomplish this goal, available to DOE to deal with mission concerns. The report expands on goals from TAC's mission statement, which include management concerns, environment, safety, and health, quality, technical support, communications, and personnel
This report presents the general management structure of the Technical Assistance Contractor (TAC) for the Uranium Mill Tailings Remedial Action (UMTRA) Project. This team is a partnership of four major private subcontractors, which teamed together, are striving to be the leader in environmental restoration of uranium mining and milling operations. It will provide a pool of experts in various aspects of the technologies necessary to accomplish this goal, available to DOE to deal with mission concerns. The report expands on goals from TAC`s mission statement, which include management concerns, environment, safety, and health, quality, technical support, communications, and personnel.
Mundt, Filip; Nilsonne, Gustav; Arslan, Sertaç; Csürös, Karola; Hillerdal, Gunnar; Yildirim, Huseyin; Metintas, Muzaffer; Dobra, Katalin; Hjerpe, Anders
Diagnosis of malignant mesothelioma is challenging. The first available diagnostic material is often an effusion and biochemical analysis of soluble markers may provide additional diagnostic information. This study aimed to establish a predictive model using biomarkers from pleural effusions, to allow early and accurate diagnosis. Effusions were collected prospectively from 190 consecutive patients at a regional referral centre. Hyaluronan, N-ERC/mesothelin, C-ERC/mesothelin, osteopontin, syndecan-1, syndecan-2, and thioredoxin were measured using ELISA and HPLC. A predictive model was generated and validated using a second prospective set of 375 effusions collected consecutively at a different referral centre. Biochemical markers significantly associated with mesothelioma were hyaluronan (odds ratio, 95% CI: 8.82, 4.82-20.39), N-ERC/mesothelin (4.81, 3.19-7.93), CERC/mesothelin (3.58, 2.43-5.59) and syndecan-1 (1.34, 1.03-1.77). A two-step model using hyaluronan and N-ERC/mesothelin, and combining a threshold decision rule with logistic regression, yielded good discrimination with an area under the ROC curve of 0.99 (95% CI: 0.97-1.00) in the model generation dataset and 0.83 (0.74-0.91) in the validation dataset, respectively. A two-step model using hyaluronan and N-ERC/mesothelin predicts mesothelioma with high specificity. This method can be performed on the first available effusion and could be a useful adjunct to the morphological diagnosis of mesothelioma.
Terrell, Ronald G
... a panacea. For a combatant commander to effectively integrate them with his military force requires an understanding of the operational environment, contractor capabilities, acceptable levels of risk...
Imamura, Osamu; Okada, Hiroaki; Takashima, Yuuki; Zhang, Danqing; Kobayashi, Toshiyuki; Hino, Okio
Silencing of gene expression by small interfering RNAs (siRNAs) is rapidly becoming a powerful tool for genetic analysis and represents a potential strategy for therapeutic product development. However, there are no reports of systemic delivery of siRNAs for stable treatment except short hairpin RNAs (shRNAs). On the other hand, there are many reports of systemic delivery of siRNAs for transient treatment using liposome carriers and others. With regard to shRNAs, a report showed fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Therefore, we decided to use original siRNA microspheres instead of shRNA for stable treatment of disease. In this study, we designed rat-specific siRNA sequences for Erc/mesothelin, which is a tumor-specific gene expressed in the Eker (Tsc2 mutant) rat model of hereditary renal cancer and confirmed the efficacy of gene silencing in vitro. Then, by using siRNA microspheres, we found that the suppression of Erc/mesothelin caused growth inhibition of Tsc2 mutant renal carcinoma cells in tumor implantation experiments in mice.
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor Performance... AGENCY ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Contractor Performance Evaluations 1509.170-8 Contractor Performance Report. (a) Contractor Performance Reports (interim and final) must be prepared...
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor-acquired... Possession of Contractors 1845.502-70 Contractor-acquired property. All contractor-acquired property must be... contractor-acquired. (2) Submission of DD Form 1419, DOD Industrial Plant Requisition, or equivalent format...
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contractor....207-5 Contractor responsibilities. Contractor responsibilities vary with the kinds of freight to be... furnished by the contractor. Otherwise, state that the contractor shall furnish clean and sound closed-type...
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Central contractor... Central contractor registration. Contractors are not required to be registered in the Central Contractor.... (See 4.1102). However, contractors are required to register with CCR in order to gain access to the...
Rapp, Randy R; Baroudi, Bassam
Successful project managers draw their performance from essential leadership traits, as guided by their core values.Within disaster recovery, contractors who mitigate, repair, and reconstruct the built environment are often faced with challenges exceeding the norm. The effective leader is commonly expected to consider stakeholder motivations within distressing situations as well as other external and environmental factors when seeking to lead the project team to successful outcomes. This research is most concerned with leadership within the context of disaster restoration of the built environment. Its stimulus comes from the Restoration Industry Association (RIA)'s efforts to highlight leadership traits and core values for its Certified Restorer Body of Knowledge but would be of value to others associated with disaster recovery operations. Among organizations whose membership includes thousands of practitioners who restore and reconstruct the built environment after disasters, the RIA is the only one yet to formally and substantially research which core values and leader traits are deemed critical for the success of efforts to manage the means and methods applied on recovery job sites. Forty-six seasoned disaster restoration industry project professionals voluntarily responded to a survey questionnaire that sought their opinions about the traits and core values that they consider most important for successful disaster restoration project leadership. The most important leader traits were effective communication, professional competence, and leadership by example. The most important restoration industry values were integrity, compassion, and trustworthiness. The recognized imperative of compassion was unexpected in light of stereotypes often associated with construction-related contractors. This and other findings permit disaster response and recovery stakeholders to better understand qualities they should wish to see in leaders of contractor organizations, which
Gisvold, K.M. [Golar-Nor Offshore, Trondheim (Norway)
This paper presents some thoughts on the Production Contractor concept. It starts with an attempt to define the prerequisites for such contractorship to exist and develop, going on to examine the considerations that the oil company and the contractor respectively have to go through, and finally trying to summarize what emerges as the advantages of production contracting. Examples are given to emphasize particular points
Full Text Available in the article an order of accounting reflection of payments with suppliers and contractors are researched and ways of enhancement of accounting calculations process development with the purpose of management decisions optimization for their implementation are offered. Theoretical bases of intraeconomic control of settlings with suppliers and contractors are developed.
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Program 3 Prevention Program § 68.87 Contractors. (a) Application. This... specialty work on or adjacent to a covered process. It does not apply to contractors providing incidental...
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contractor inquiries. 32.909 Section 32.909 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Prompt Payment 32.909 Contractor inquiries. (a) Direct questions...
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contractor's signature. 4.102 Section 4.102 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Contract Execution 4.102 Contractor's signature. (a) Individuals. A contract with an...
... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Contractor eligibility. 875.20 Section 875.20 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION CERTIFICATION AND NONCOAL RECLAMATION § 875.20 Contractor eligibility. Every...
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor qualifications. 1553.209 Section 1553.209 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CLAUSES AND FORMS FORMS Prescription of Forms 1553.209 Contractor qualifications. ...
... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Contractor eligibility. 874.16 Section 874.16 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION GENERAL RECLAMATION REQUIREMENTS § 874.16 Contractor eligibility. To receive...
... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contractor qualifications. 253.209 Section 253.209 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.209 Contractor qualifications. ...
... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contractor qualifications. 53.209 Section 53.209 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.209 Contractor qualifications. ...
This paper presents some thoughts on the Production Contractor concept. It starts with an attempt to define the prerequisites for such contractorship to exist and develop, going on to examine the considerations that the oil company and the contractor respectively have to go through, and finally trying to summarize what emerges as the advantages of production contracting. Examples are given to emphasize particular points
Imashimizu, Kohta; Shiomi, Kazu; Maeda, Masahiro; Aoki, Naoko; Igarashi, Kiyoko; Suzuki, Fumio; Koizumi, Mitsuru; Suzuki, Kenji; Hino, Okio
A large-scale screening involving the measurement of N-ERC/mesothelin levels in blood using an ELISA system for the early diagnosis of malignant mesothelioma (MM) was carried out in individuals with a history of employment at construction sites. Approximately 30,000 subjects were screened. Of the 80 subjects with high-risk values, one male patient was diagnosed as having MM based on a PET study and histopathology. This is the first report of the pre-clinical diagnosis of MM based on blood test screening. In addition, plasma levels of N-ERC/mesothelin may be effectively used for monitoring relapse after surgery.
..., Sequence 1] RIN 9000-AM09 Federal Acquisition Regulation; Documenting Contractor Performance AGENCY... the Contractor Performance Assessment Reporting System (CPARS), the single Governmentwide past... Procurement Policy (OFPP) memorandum entitled ``Improving the Use of Contractor Performance Information...
... Federal Acquisition Regulation; Documenting Contractor Performance AGENCY: Department of Defense (DoD..., and to require all past performance information be entered into the Contractor Performance Assessment... Contractor Performance Information. These changes provide Governmentwide standardized evaluation factors and...
... Contractor Recruitment Standards AGENCY: Employment and Training Administration, Labor. ACTION: Final notice... issuing this notice to announce recruitment standards that construction contractors are required to follow... B) by adding a new subsection (6). This provision prohibits contractors engaged in construction...
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contractor purchasing... SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Management and Operating Contractor Purchasing 970.4402 Contractor purchasing system. ...
... Regulation; Documenting Contractor Performance; Correction AGENCY: Department of Defense (DoD), General... August 9, 2011, regarding the proposed rule for Documenting Contractor Performance. DATES: The comment...
Airik, Rannar; Schueler, Markus; Airik, Merlin
Recessive mutations in the SDCCAG8 gene cause a nephronophthisis-related ciliopathy with Bardet-Biedl syndrome-like features in humans. Our previous characterization of the orthologous Sdccag8gt/gt mouse model recapitulated the retinal-renal disease phenotypes and identified impaired DNA damage...... response signaling as an underlying disease mechanism in the kidney. However, several other phenotypic and mechanistic features of Sdccag8gt/gt mice remained unexplored. Here we show that Sdccag8gt/gt mice exhibit developmental and structural abnormalities of the skeleton and limbs, suggesting impaired...... Hedgehog (Hh) signaling. Indeed, cell culture studies demonstrate the requirement of SDCCAG8 for ciliogenesis and Hh signaling. Using an affinity proteomics approach, we demonstrate that SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, AZI1), of the endosomal sorting complex (RABEP2, ERC...
Sharma, R.; Murali, S.; Singh, Rajvir; Pradeepkumar, K.S.
The radiological emergencies are very rare in occurrence the mechanism to improve the preparedness can be ensured through conducting mock exercises/drills. Emergency kit comprises of adequate number of radiation monitoring equipments and PPEs required for response is kept in readiness at ERC. There is a need of training modules on radiological emergencies for all stake holders e.g. district officials, Local Police, Medical professionals and National Disaster Response Force (NDRF) to improve the knowledge and response capability. The adaptability to situations is important for ERTs based on the lessons learned from emergency at Mayapuri, Delhi. The role and responsibility of different agencies have been identified and drafted in the preparedness plan to meet the challenges during response
The Technical Assistance Contractor (TAC) for the Uranium Mill Tailings Remedial Action (UMTRA) Project comprises Jacobs Engineering Group Inc. (JEG) and its major teaming partners [Roy F. Weston, Inc. (RFW), Sergent, Hauskins ampersand Beckwith Agra, Inc. (SHB Agra), and Geraghty ampersand Miller, Inc. (G ampersand M)]. The first three companies have worked together effectively on the UMTRA Project for more than 10 years. With the initiation of the UMTRA Groundwater Project in April 1991, a need arose to increase the TAC's groundwater technical breadth and depth, so G ampersand M was brought in to augment the team's capabilities. The TAC contract's scope is to provide technical, analytical, environmental, engineering, design, inspection, and management support services to the US Department of Energy (DOE) for both surface and groundwater projects. The TAC team continues to support the DOE in completing surface remedial actions and initiating groundwater remediation work for start-up, characterization, design, construction oversight, and remedial operations. A key feature of the TAC's management approach is the extensive set of communication systems implemented for the UMTRA Project. These systems assist all functional disciplines in performing UMTRA Project tasks associated with management, technical support, administrative support, and financial/project controls
Nakaishi, Masayuki; Kajino, Kazunori; Ikesue, Masahiro; Hagiwara, Yoshiaki; Kuwahara, Maki; Mitani, Hiroaki; Horikoshi-Sakuraba, Yuko; Segawa, Tatsuya; Kon, Shigeyuki; Maeda, Masahiro; Wang, Tegexibaiyin; Abe, Masaaki; Yokoyama, Masayoshi; Hino, Okio
By representational difference analysis, we previously identified the rat Erc (Expressed in renal carcinoma) gene that was more abundantly expressed in the renal carcinoma tissues of Eker rats than in the rat normal kidney. In this study, we raised antibodies against the amino-terminal portion of the rat Erc, and demonstrated the existence of a approximately 30-kDa secretory form in the supernatant of cultured cells derived from rat renal carcinoma. The enzyme-linked immunosorbent assay (ELISA) system using these antibodies detected high concentrations of this form in the sera of Eker rats bearing renal carcinomas, and in the sera of rats transplanted with mesothelioma cells. Mesothelin, a human homolog of the rat Erc, was recently reported to be a serum marker of malignant mesothelioma. The prognosis of mesothelioma is poor and there is no effective treatment at present. There are several rat model systems of mesothelioma that may be promising tools in the development of an antimesothelioma treatment. We hope our ELISA to detect the soluble form of rat Erc/Mesothelin is useful in the rat model system to exploit the antimesothelioma therapy to be used in human cases.
Wiese, C H R; Semmel, T; Müller, J U; Bahr, J; Ocker, H; Graf, B M
In the current guidelines of the European Resuscitation Council (ERC), tracheal intubation, as an instrument for securing the airway during resuscitation, has become less important for persons not trained in this method. For those persons, different supraglottic airway devices are recommended by the ERC. The present investigation deals with the application of the laryngeal tube disposable (LT-D) during pre-hospital resuscitation by paramedics. During a period of 2 years (2006-2008), we registered all cardiac arrest situations in which the LT-D had been applied according to the ERC guidelines 2005. Therefore, we investigated one emergency medical system in Germany. During the defined period, 92 resuscitation attempts, recorded on standardised data sheets, were included. The LT-D was used in 46% of all cardiac arrest situations. Overall, the LT-D was successfully inserted in more than 90% of all cases on first attempt. In 95% of all cases, no problems concerning ventilation of the patient were described. As an alternative airway device recommended by the ERC in 2005, the LT-D may enable airway control rapidly and effectively. Additionally, by using the LT-D, a reduced "no-flow-time" and a better outcome may be possible.
Hispanic Association of Colleges and Universities, 2011
With support from the Lumina Foundation, the Hispanic Association of Colleges and Universities (HACU) has launched HACU's Hispanic Higher Education Research Collective (H3ERC). The first major task of this virtual gathering of researchers and practitioners in Hispanic higher education has been to assess the state of our knowledge of the key issues…
May, Catherine E; Schulman, Martin L; Howell, Peter G; Lourens, Carina W; Gouws, Johan; Joone, Christopher; Monyai, Mpho S; le Grange, Misha; Bezuidt, Oliver K I; Harper, Cindy K; Guthrie, Alan J
Taylorella equigenitalis is the causative agent of contagious equine metritis (CEM), a sexually transmitted infection of horses. We report here the genome sequence of T. equigenitalis strain ERC_G2224, isolated in 2015 from a semen sample collected in 1996 from a Lipizzaner stallion in South Africa. Copyright © 2015 May et al.
Durfee, Justin David; Frazier, Christopher Rawls; Bandlow, Alisa; Jones, Katherine A
This document describes the final software design of the Contingency Contractor Optimization Tool - Prototype. Its purpose is to provide the overall architecture of the software and the logic behind this architecture. Documentation for the individual classes is provided in the application Javadoc. The Contingency Contractor Optimization project is intended to address Department of Defense mandates by delivering a centralized strategic planning tool that allows senior decision makers to quickly and accurately assess the impacts, risks, and mitigation strategies associated with utilizing contract support. The Contingency Contractor Optimization Tool - Prototype was developed in Phase 3 of the OSD ATL Contingency Contractor Optimization project to support strategic planning for contingency contractors. The planning tool uses a model to optimize the Total Force mix by minimizing the combined total costs for selected mission scenarios. The model optimizes the match of personnel types (military, DoD civilian, and contractors) and capabilities to meet mission requirements as effectively as possible, based on risk, cost, and other requirements.
Full Text Available PURPOSE: Diagnosis of malignant mesothelioma is challenging. The first available diagnostic material is often an effusion and biochemical analysis of soluble markers may provide additional diagnostic information. This study aimed to establish a predictive model using biomarkers from pleural effusions, to allow early and accurate diagnosis. PATIENTS AND METHODS: Effusions were collected prospectively from 190 consecutive patients at a regional referral centre. Hyaluronan, N-ERC/mesothelin, C-ERC/mesothelin, osteopontin, syndecan-1, syndecan-2, and thioredoxin were measured using ELISA and HPLC. A predictive model was generated and validated using a second prospective set of 375 effusions collected consecutively at a different referral centre. RESULTS: Biochemical markers significantly associated with mesothelioma were hyaluronan (odds ratio, 95% CI: 8.82, 4.82-20.39, N-ERC/mesothelin (4.81, 3.19-7.93, CERC/mesothelin (3.58, 2.43-5.59 and syndecan-1 (1.34, 1.03-1.77. A two-step model using hyaluronan and N-ERC/mesothelin, and combining a threshold decision rule with logistic regression, yielded good discrimination with an area under the ROC curve of 0.99 (95% CI: 0.97-1.00 in the model generation dataset and 0.83 (0.74-0.91 in the validation dataset, respectively. CONCLUSIONS: A two-step model using hyaluronan and N-ERC/mesothelin predicts mesothelioma with high specificity. This method can be performed on the first available effusion and could be a useful adjunct to the morphological diagnosis of mesothelioma.
During the United States federal government acquisition reform movement of the 1990s, the government strongly emphasized the use of past performance information to select contractors in federal procurements...
Keywords: Institutions; small-scale contractor performance; sugar industry. ABSTRACT ..... diverse cultural settings, women, specifically widowed or single women, have a .... constraints on business growth, such as the work limitations placed.
Solmio, H; Tuomi, S; Valkonen, J
Heating contractor is eg. a forest owner, who is responsible for the heating of a commune owned school using firewood purchased from the contractor`s own forests. This is a new alternative for entrepreneurship in the countryside. This guide has been meant as an aid for persons starting heating contraction. It is supposed to be of importance for the designers of the communal energy supply, for advisors and instructors, as well as for those already started the heating contraction. The guide discusses the following topics: Why to became a heating contractor; The ways of heating contraction; operational requirements; Contracts; Conversion of a boiler plant to wood fuels; Fuel purchase; Heating work; Profitably estimation; Examples of operational solutions. The guide also includes as an example a draft contract for heating contraction
The purpose of this document is to familiarize and encourage brownfields decision makers to investigate and employ innovative methods for characterizing their sites, to assist brownfields decision makers in assessing contractors' capabilities.
U.S. Department of Health & Human Services — A redetermination is an examination of a claim by the fiscal intermediary (FI), carrier, or Medicare Administrative Contractor (MAC) personnel who are different from...
Gratton, David G; Aquilino, Steven A
Interim restorations are a critical component of fixed prosthodontic treatment, biologically and biomechanically. Interim restoration serves an important diagnostic role as a functional and esthetic try-in and as a blueprint for the design of the definitive prosthesis. When selecting materials for any interim restoration, clinicians must consider physical properties, handling properties, patient acceptance, and material cost. Although no single material meets all the requirements and material classification alone of a given product is not a predictor of clinical performance, bis-acryl materials are typically best suited to single-unit restorations, and poly(methylmethacrylate) interim materials are generally ideal for multi-unit, complex, long-term, interim fixed prostheses. As with most dental procedures, the technique used for fabrication has a greater effect on the final result than the specific material chosen.
Jacobs, Douglass F.; Oliet, Juan A.; Aronson, James
of land requiring restoration implies the need for spatial prioritization of restoration efforts according to cost-benefit analyses that include ecological risks. To design resistant and resilient ecosystems that can adapt to emerging circumstances, an adaptive management approach is needed. Global change......, in particular, imparts a high degree of uncertainty about the future ecological and societal conditions of forest ecosystems to be restored, as well as their desired goods and services. We must also reconsider the suite of species incorporated into restoration with the aim of moving toward more stress resistant...... and competitive combinations in the longer term. Non-native species may serve an important role under some circumstances, e.g., to facilitate reintroduction of native species. Propagation and field establishment techniques must promote survival through seedling stress resistance and site preparation. An improved...
Penny, M.; Vasey, G.M.
This article will discuss the advantages of Information Technology (IT) and how one drilling contractor, Global Marine, has applied this technology. The company has applied it in an efficient manner which has provided business benefits and cost reductions that have helped its operations be more successful. The following are the different aspects of information technology that led to the contractor's success: cost reduction measures; migration to a client/server IT infrastructure; IT business benefits; and keys to obtaining business benefits from IT
Woods, Eric; Homer, John
As cleanup workers excavate pits and tear down buildings at the Fernald site in southwest Ohio, site ecologists are working side-by-side to create thriving wetlands and develop the early stages of forest, prairie, and savanna ecosystems to restore natural resources that were impacted by years of site operations. In 1998, the U.S. Department of Energy-Fernald Office (DOE-FN) and its cleanup contractor, Fluor Fernald, Inc., initiated several ecological restoration projects in perimeter areas of the site (e.g., areas not used for or impacted by uranium processing or waste management). The projects are part of Fernald's final land use plan to restore natural resources over 904 acres of the 1,050-acre site. Pete Yerace, the DOE-FN Natural Resource Trustee representative is working with the Fernald Natural Resource Trustees in an oversight role to resolve the state of Ohio's 1986 claim against DOE for injuries to natural resources. Fluor Fernald, Inc., and DOE-FN developed the ''Natural Resource Restoration Plan'', which outlines 15 major restoration projects for the site and will restore injured natural resources at the site. In general, Fernald's plan includes grading to maximize the formation of wetlands or expanded floodplain, amending soil where topsoil has been removed during excavation, and establishing native vegetation throughout the site. Today, with cleanup over 35 percent complete and site closure targeted for 2006, Fernald is entering a new phase of restoration that involves heavily remediated areas. By working closely with engineers and cleanup crews, site ecologists can take advantage of remediation fieldwork (e.g., convert an excavated depression into a wetland) and avoid unnecessary costs and duplication. This collaboration has also created opportunities for relatively simple and inexpensive restoration of areas that were discovered during ongoing remediation. To ensure the survival of the plant material in heavily
The provisions of the Environmental Protection and Enhancement Act (EPEA) regarding the relationship between a company and an independent contractor were reviewed. The EPEA was introduced in September 1993 and significantly altered the environmental laws in the province of Alberta. The provisions of the EPEA that apply to the petroleum industry are conservation and reclamation as well as provisions concerning release of substances, contaminated sites and penalties. Companies that pollute may be held liable for reclamation, even if the work was carried out by an independent contractor and despite the fact that the independent contractor is not an employee of the company. Under the current EPEA laws, companies may not be able to effectively shift responsibility for environmental liabilities to independent contractors even where the contractor was negligent. This paper presented suggestions regarding contractor agreements and due diligence to help minimize the risk of liability to companies. The paper also discussed the following two types of liabilities under the EPEA's harmful substances section: (1) the obligation to clean up an affected area, and (2) fines and penalties that may be imposed when an offence is committed
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contractor testimony. 1252... Contractor testimony. As prescribed in (TAR) 48 CFR 1242.7000(b), insert the following clause: Contractor Testimony (OCT 1994) All requests for the testimony of the Contractor or its employees, and any intention to...
... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contractor Inspection....246-1 Contractor Inspection Requirements. As prescribed in 46.301, insert the following clause: Contractor Inspection Requirements (APR 1984) The Contractor is responsible for performing or having...
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contractor purchasing... for Management and Operating Contracts 970.5244-1 Contractor purchasing system. As prescribed in 970.4403 insert the following clause: Contractor Purchasing System (AUG 2009) (a) General. The Contractor...
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Government-Contractor... 1552.237-76 Government-Contractor Relations. As prescribed in 1537.110(g), insert the following clause: Government-Contractor Relations (JUN 1999) (a) The Government and the Contractor understand and agree that...
... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contractor's Facilities....241-5 Contractor's Facilities. As prescribed in 41.501(c)(4), insert a clause substantially the same as the following: Contractor's Facilities (FEB 1995) (a) The Contractor, at its expense, unless...
... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contractor's Invoices. 52....247-28 Contractor's Invoices. As prescribed in 47.207-9(c), insert the following clause in... services: Contractor's Invoices (APR 1984) The Contractor shall submit itemized invoices as instructed by...
... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Central Contractor....204-7 Central Contractor Registration. As prescribed in 4.1105, use the following clause: Central Contractor Registration (APR 2008) (a) Definitions. As used in this clause— Central Contractor Registration...
... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Independent contractor register. 45.4 Section... ADMINISTRATIVE REQUIREMENTS INDEPENDENT CONTRACTORS § 45.4 Independent contractor register. (a) Each independent contractor shall provide the production-operator in writing the following information: (1) The independent...
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contractor employee travel... Contractor employee travel discounts. As prescribed in 951.7002, insert the following clause: Contractor Employee Travel Discounts (AUG 2009) (a) The Contractor shall take advantage of travel discounts offered to...
... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false License to contractor. 1245.108 Section... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.108 License to contractor. (a) Each contractor.... The license extends to the contractor's domestic subsidiaries and affiliates, if any, within the...
... contractor. 1852.209-72 Section 1852.209-72 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND... and Clauses 1852.209-72 Composition of the contractor. As prescribed in 1809.670, insert the following clause: Composition of the Contractor (DEC 1988) If the Contractor is comprised of more than one legal...
... 42 Public Health 4 2010-10-01 2010-10-01 false Limitation on contractor liability. 455.202 Section... § 455.202 Limitation on contractor liability. (a) A program contractor, a person, or an entity employed... contractor will not be held to have violated any criminal law and will not be held liable in any civil action...
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contractor-mission....7013 Contractor-mission relationships. For use in all USAID contracts involving performance overseas.... Contractor-Mission Relationships (OCT 1989) (a) The Contractor acknowledges that this contract is an...
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contractor....237-70 Contractor responsibilities. As prescribed in 837.110, insert the following clause: Contractor Responsibilities (APR 1984) The contractor shall obtain all necessary licenses and/or permits required to perform...
As part of the Computer Protection Program, this Network Security Plan identifies the specific security measures used to protect the Bechtel Hanford, Inc. (BHI) enterprise network. The network consists of the communication infrastructure and information systems used by BHI to perform work related to the Environmental Restoration Contract (ERC) at the Hanford Site. It provides electronic communication between the ERC-leased facilities in Richland, Washington and other facilities located on the Hanford Site. Network gateways to other site and offsite networks provide electronic communication with the rest of the Hanford community. The enterprise network is comprised of several individual networks that operate under different conditions and perform different functions. The principal network used by BHI is the Bechtel Local Area Network (BLAN). This document identifies specific security issues surrounding the BLAN and the measures BHI takes to protect it. The other BHI-operated networks are discussed from the perspective of the security impact they have on the BLAN. This plan addresses security for individual and shared computer systems connected to the BHI networks as well as the gateways between other site and external networks. It specifically does not address computer-based information systems that store or process particularly sensitive data, computer systems connected to other site networks (e.g., Hanford Local Area Network), or standalone computers located in ERC facilities
Ashish R Jain
Full Text Available Rehabilitation of a patient with severely worn dentition after restoring the vertical dimension is a complex procedure and assessment of the vertical dimension is an important aspect in these cases. This clinical report describes the full mouth rehabilitation of a patient who was clinically monitored to evaluate the adaptation to a removable occlusal splint to restore vertical dimension for a period 1 month and provisional restorations to determine esthetic and functional outcome for a period of 3 months. It is necessary to recognizing that form follows function and that anterior teeth play a vital role in the maintenance of oral health. Confirmation of tolerance to changes in the vertical dimension of occlusion (VDO is of paramount importance. Articulated study casts and a diagnostic wax-up can provide important information for the evaluation of treatment options. Alteration of the VDO should be conservative and should not be changed without careful consideration.
Rawnsley, Jeffrey D
The impact of male hair loss as a personal and social marker of aging is tremendous and its persistence as a human concern throughout recorded history places it in the forefront of male concern about the physical signs of aging. Restoration of the frontal hairline has the visual effect of re-establishing facial symmetry and turning back time. Follicular unit transplantation has revolutionized hair restoration, with its focus on redistributing large numbers of genetically stable hair to balding scalp in a natural distribution. Follicular unit hair restoration surgery is a powerful tool for the facial plastic surgeon in male aesthetic facial rejuvenation because it offers high-impact, natural-appearing results with minimal downtime and risk for adverse outcome.
Barou, L.; Bristogianni, T.; Oikonomopoulou, F.
This paper investigates the application of structural glass in restoration and conservation practices in order to highlight and safeguard our built heritage. Cast glass masonry is introduced in order to consolidate a half-ruined historic tower in Greece, by replacing the original parts of the façade
Noynaert, L.; Bruggeman, A.; Cornelissen, R.; Massaut, V.; Rahier, A
The objectives, the programme, and the achievements of the Site Restoration Department of SCK-CEN in 2000 are summarised. Main activities include the decommissioning of the BR3 PWR-reactor as well as other clean-up activities, projects on waste minimisation and activities related to the management of decommissioning projects. The department provides consultancy and services to external organisations.
Noynaert, L.; Bruggeman, A.; Cornelissen, R.; Massaut, V.; Rahier, A.
The objectives, the programme, and the achievements of the Site Restoration Department of SCK-CEN in 2000 are summarised. Main activities include the decommissioning of the BR3 PWR-reactor as well as other clean-up activities, projects on waste minimisation and activities related to the management of decommissioning projects. The department provides consultancy and services to external organisations
Andres, Robert H; Meyer, Morten; Ducray, Angélique D
There is increasing interest in the search for therapeutic options for diseases and injuries of the central nervous system (CNS), for which currently no effective treatment strategies are available. Replacement of damaged cells and restoration of function can be accomplished by transplantation of...
Zeevaert, T.; Vanmarcke, H
The objectives of SCK-CEN's programme on environmental restoration are (1) to optimize and validate models for the impact assessment from environmental, radioactive contaminations, including waste disposal or discharge; (2) to support the policy of national authorities for public health and radioactive waste management. Progress and achievements in 1997 are reported.
This book reports that with incentive contracts, drilling and service contractors assume greater responsibility for operations. That helps them to align their goals more closely with those of the operator. This achieves a more equitable division of the risks. Many operators and contractors believe this is a more appropriate approach to contracting drilling services. As they assume manageable responsibility, each party also has opportunities for greater reward. Innovations in cooperation can create a win-win situation. In a win-win contract all parties benefit from the new relationships between operator, contractor, and service company. The win-win situation can only be achieved by allowing the contracting parties to become much more closely involved in drilling operations. This is the primary motivation behind development of more productive contracting strategies
Thevenon, Julien; Callier, Patrick; Andrieux, Joris; Delobel, Bruno; David, Albert; Sukno, Sylvie; Minot, Delphine; Mosca Anne, Laure; Marle, Nathalie; Sanlaville, Damien; Bonnet, Marlène; Masurel-Paulet, Alice; Levy, Fabienne; Gaunt, Lorraine; Farrell, Sandra; Le Caignec, Cédric; Toutain, Annick; Carmignac, Virginie; Mugneret, Francine; Clayton-Smith, Jill; Thauvin-Robinet, Christel; Faivre, Laurence
Speech sound disorders are heterogeneous conditions, and sporadic and familial cases have been described. However, monogenic inheritance explains only a small proportion of such disorders, in particular in cases with childhood apraxia of speech (CAS). Deletions of Speech delay was found in all patients, which could be defined as CAS when patients had been evaluated by a speech therapist (5/9 patients). Intellectual deficiency was found in 5/9 patients only, and often associated with psychiatric manifestations of various severity. Two such deletions were inherited from an apparently healthy parent, but reevaluation revealed abnormal speech production at least in childhood, suggesting variable expressivity. The ELKS/ERC1 gene, which encodes for a synaptic factor, is found in the smallest region of overlap. These results reinforce the hypothesis that deletions of the 12p13.33 locus may be responsible for variable phenotypes including CAS associated with neurobehavioural troubles and that the presence of CAS justifies a genetic work-up.
Kreimeier, U; Dirks, B; Arntz, R; Bahr, J; Goldschmidt, P; Roessler, M; Sasse, M; Toursarkissian, M
Basic life support (BLS) refers to maintaining airway patency and supporting breathing and the circulation, without the use of equipment other than infection protection measures. The scientific advisory committee of the American Heart Association (AHA) published recommendations (online-first) on March 31 2008, which promote a call to action for bystanders who are not or not sufficiently trained in cardiopulmonary resuscitation (CPR) and witness an adult out-of-hospital sudden collapse probably of cardiac origin. These bystanders should provide chest compression without ventilation (so-called compression-only CPR). If bystanders were previously trained and thus confident with CPR, they should decide between conventional CPR (chest compression plus ventilation at a ratio of 30:2) and chest compression alone. However, considering current evidence-based medicine and latest scientific data both the European Resuscitation Council (ERC) and the German Resuscitation Council (GRC) do not at present intend to change or supplement the current resuscitation guidelines "Basic life support for adults". Both organisations do not see any need for change or amendments in central European practice and continue to recommend that only those lay rescuers that are not willing or unable to give mouth-to-mouth ventilation should provide CPR solely by uninterrupted chest compressions until professional help arrives. It is also stressed that the training of young people especially teenagers as lay rescuers should be promoted and the establishment of training programs through emergency medical organizations and in schools should be encouraged.
Full Text Available Recessive mutations in the SDCCAG8 gene cause a nephronophthisis-related ciliopathy with Bardet-Biedl syndrome-like features in humans. Our previous characterization of the orthologous Sdccag8gt/gt mouse model recapitulated the retinal-renal disease phenotypes and identified impaired DNA damage response signaling as an underlying disease mechanism in the kidney. However, several other phenotypic and mechanistic features of Sdccag8gt/gt mice remained unexplored. Here we show that Sdccag8gt/gt mice exhibit developmental and structural abnormalities of the skeleton and limbs, suggesting impaired Hedgehog (Hh signaling. Indeed, cell culture studies demonstrate the requirement of SDCCAG8 for ciliogenesis and Hh signaling. Using an affinity proteomics approach, we demonstrate that SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, AZI1, of the endosomal sorting complex (RABEP2, ERC1, and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14 at the centrosome. Furthermore, we show that RABEP2 localization at the centrosome is regulated by SDCCAG8. siRNA mediated RABEP2 knockdown in hTERT-RPE1 cells leads to defective ciliogenesis, indicating a critical role for RABEP2 in this process. Together, this study identifies several centrosome-associated proteins as novel SDCCAG8 interaction partners, and provides new insights into the function of SDCCAG8 at this structure.
Bird, H.M.B.; Flemming, J.P.
The ERC cold-cathode ion source has been in routine production use on several PR-30 systems for the past three years. This source has been further developed to improve target current, lifetime, and stability. The ion-optical lens has been changed from circular to elliptical geometry in order to provide an asymmetric beam for entry into the PR-30 analyzing magnet. This measure, as well as the use of higher extraction voltages, provides higher beam currents on the PR-30 target wafers. Beam steering in the nondispersive direction has been provided to correct the effects of minor machine misalignments, further enhancing target current. The discharge chamber has been modified to increase source lifetime. A new gas-feed control system and a new method of oven temperature control have been devised to provide good source and ion beam stability. The source operates with only occasional attention by unskilled personnel, and has been used principally for boron and arsenic implants. Target currents of 1-mA boron and 4-mA arsenic can be obtained routinely. Lifetimes are of the order of 40--80 h, depending on ion species. The source has also been used to provide 5-mA phosphorus, 4-mA argon, 3-mA helium and neon, and 0.3-mA nickel and palladium ion beams
Koch, Christian; Buhl, Henrik
Over the past ten years, a series of contractors operating in Denmark, Norway and Sweden have slowly but surely expanded their markets beyond their previous single-country base towards operating in Scandinavia as a whole, and beyond. This expansion has been accompanied by a restructuring of company...... management and HR concepts and approaches. Methodologically, a sample of the top level leaders of the hundred largest business units at some thirty Scandinavian contractors has been analysed. The focus is on the 400 top level managers in these organisations. On the basis of a desk study, an analysis of 124...
Results show that contractors face institutional constraints (work allocation limitations, lack of performance incentives and high transaction costs, such as negotiation costs, the risk of a loss in work and contract default risk), cash flow problems, poor physical infrastructure and a lack of labour. It is expected that the promotion ...
its business unit Thyssen Krupp Marine Systems, is a German defense contractor. (2) Tognom AG Tognum AG owned the MTU Friedrichshafen GmbH before... Friedrichshafen provided engines for many ships of the German Navy and for German battle tanks, such as the Leopard I and Leopard II. MTU refers to the
The client's aim in any decommissioning project is that the originally intended end point is achieved, within budget and on time. The contractor's aim is to have a satisfied client, so that both are happy to work together again, and to have a reasonable return for his efforts. How can these - not incompatible - aims best be achieved? (UK)
The end of the Cold War witnessed the growth and spread of legally established private military contractors (PMCs) playing largely undefined roles in wars, international security and post-conflict reconstruction. The operations of PMCs in Iraq and Afghanistan in the 21st century have been marked by gross human rights ...
Dlungwana, Wilkin S
Full Text Available Construction industry and indeed all small and medium-sized contractors play a significant socio-economic role in the developing countries. This paper highlights the importance of promoting sustainable building through the implementation...
Durfee, Justin David; Frazier, Christopher Rawls; Bandlow, Alisa
The Contingency Contractor Optimization Tool - Prototype (CCOT-P) requires several third-party software packages. These are documented below for each of the CCOT-P elements: client, web server, database server, solver, web application and polling application.
.... Specifically, this document will focus on how the outcome of capital facility projects are affected by human resources practices, and the management principles and practices of the contractor-owner...
Burdick, Arlan [IBACOS Inc., Pittsburgh, PA (United States)
This expert meeting was hosted by the IBACOS Building America research team to determine how HVAC companies can transition from a traditional contractor status to a service provider for whole house energy upgrade contracting.
... inventory. 645.608 Section 645.608 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Redistribution, and Disposal of Contractor Inventory 645.608 Screening of contractor inventory. ...
Contractors on the Battlefield: Planning Considerations and Requirements introduces the basics and foundation for those who want to learn about the history, terminology, and process for obtaining contractor support on the battlefield...
..., [email protected] . SUPPLEMENTARY INFORMATION: I. Abstract The NASA Contractor Financial Management... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-019] Information Collection; NASA Contractor Financial Management Reports AGENCY: National Aeronautics and Space Administration (NASA). ACTION...
The role of contractors in warfare has changed dramatically. As the Services have drawn down, more and more of the duties formerly accomplished by military members are being performed by contractors...
The Department of Energy and its contractors are faced with environmental concerns and large waste management costs. Federal legislation and DOE Orders require sites to develop waste minimization/pollution prevention programs. In response to these requirements, the Kansas City Plant developed a pollution prevention tool called a pollution prevention opportunity assessment (PPOA). Pilot assessments resulted in the development of a graded approach to reduce the amount of effort required for activities that utilized nonhazardous and/or low-volume waste streams. The project`s objectives in FY95 were to validate DOE`s PPOA Graded Approach methodology, provide PPOA training and technical assistance to interested DOE personnel and DOE contractors, enhance the methodology with energy analysis and tools for environmental restoration activities, implement a DOE-wide PPOA database, and provide support to DOE EM-334 in the completion of a report which estimates the future potential for pollution prevention and waste minimization in the DOE complex.
The Department of Energy and its contractors are faced with environmental concerns and large waste management costs. Federal legislation and DOE Orders require sites to develop waste minimization/pollution prevention programs. In response to these requirements, the Kansas City Plant developed a pollution prevention tool called a pollution prevention opportunity assessment (PPOA). Pilot assessments resulted in the development of a graded approach to reduce the amount of effort required for activities that utilized nonhazardous and/or low-volume waste streams. The project's objectives in FY95 were to validate DOE's PPOA Graded Approach methodology, provide PPOA training and technical assistance to interested DOE personnel and DOE contractors, enhance the methodology with energy analysis and tools for environmental restoration activities, implement a DOE-wide PPOA database, and provide support to DOE EM-334 in the completion of a report which estimates the future potential for pollution prevention and waste minimization in the DOE complex
... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Screening of contractor inventory. 245.608 Section 245.608 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Disposal of Contractor Inventory 245.608 Screening of contractor inventory. ...
... POSTAL SERVICE 39 CFR Part 230 Office of Inspector General; Contractor Requirements AGENCY: Postal... for contractors employed by the Office of Inspector General. The rule also emphasizes consistency in contractor selection, and clarifies the OIG's exclusive authority to set qualifications and standards for its...
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contractor inspection... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.301 Contractor inspection requirements. The contracting officer shall insert the clause at 52.246-1, Contractor Inspection Requirements, in solicitations...
... DEPARTMENT OF ENERGY 10 CFR Part 719 48 CFR Parts 931, 952 and 970 RIN 1990-AA37 Contractor Legal... Energy (DOE or Department) is proposing to revise existing regulations covering contractor legal... costs by certain contractors whose contracts exceed $100,000,000 as well as legal counsel retained...
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contractor's organization... for Management and Operating Contracts 970.5203-3 Contractor's organization. As prescribed in 970.0371-9, insert the following clause: Contractor's Organization (DEC 2000) (a) Organization chart. As...
... DEPARTMENT OF ENERGY 10 CFR Part 719 48 CFR Parts 931, 952, and 970 RIN 1990-AA37 Contractor Legal.... ACTION: Final rule. SUMMARY: The Department of Energy revises existing regulations covering contractor... costs by certain contractors whose contracts exceed $100,000,000 as well as legal counsel retained...
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor employee travel... 2452.251-70 Contractor employee travel. As prescribed in 2451.7001, insert the following clause in all cost-reimbursement solicitations and contracts involving travel: Contractor Employee Travel (OCT 1999...
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contractor requests. 450.303-1 Section 450.303-1 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACT MANAGEMENT EXTRAORDINARY CONTRACTUAL ACTIONS Contract Adjustments 450.303-1 Contractor requests. Contractor...
... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Evaluation of contractor... Construction 2936.201 Evaluation of contractor performance. The HCA must establish procedures to evaluate construction contractor performance and prepare performance reports as required by FAR 36.201. ...
... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contractor employee access... CLAUSES Text of Provisions and Clauses 3052.204-71 Contractor employee access. As prescribed in (HSAR) 48...: Contractor Employee Access (JUN 2006) (a) “Sensitive Information,” as used in this Chapter, means any...
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Prime contractor alternate... CONTRACT MANAGEMENT GOVERNMENT PROPERTY Support Government Property Administration 45.501 Prime contractor... administration from another contract administration office, for purposes of evaluating prime contractor...
... Regulation; Documenting Contractor Performance; Correction AGENCY: Department of Defense (DoD), General... published in the Federal Register of June 28, 2011, regarding the proposed rule for Documenting Contractor... published in the Federal Register of June 28, 2011, regarding the proposed rule for Documenting Contractor...
... 32 National Defense 6 2010-07-01 2010-07-01 false Contractor prepared documents. 989.23 Section... PROTECTION ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.23 Contractor prepared documents. All Air Force... should reflect on the cover sheet they are an Air Force document. Contractor preparation information...
... DEPARTMENT OF ENERGY 10 CFR Part 719 48 Parts 931, 952 and 970 RIN 1990-AA37 Contractor Legal... rulemaking (NOPR) to revise existing regulations covering contractor legal management requirements and make... relating to the DOE notice of proposed rulemaking to revise existing regulations covering contractor legal...
... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Evaluation of contractor performance. 3036.201 Section 3036.201 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY... contractor performance. (a)(2) Performance reports shall be prepared and entered into the Contractor...
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor performance... 1552.209-76 Contractor performance evaluations. As prescribed in section 1509.170-1, insert the following clause in all applicable solicitations and contracts. Contractor Performance Evaluations (OCT 2002...
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor records... PRECONTRACT PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 2152.215-70 Contractor records retention. As prescribed in 2115.071, insert the following clause: Contractor Records Retention (OCT 2005...
... contractor. 36.506 Section 36.506 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Superintendence by the contractor. The contracting officer shall insert the clause at 52.236-6, Superintendence by the Contractor, in solicitations and contracts when a fixed-price construction contract or a fixed...
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contractor Performance... ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Federal Supply Schedules 8.406-7 Contractor Performance Evaluation. Ordering activities must prepare an evaluation of contractor performance for each...
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor records... of FEHBP Clauses 1652.204-70 Contractor records retention. As prescribed in 1604.705 the following clause will be inserted in all FEHB Program contracts. Contractor Records Retention (JUL 2005...
... contractor employees. 1252.237-70 Section 1252.237-70 Federal Acquisition Regulations System DEPARTMENT OF....237-70 Qualifications of contractor employees. As prescribed in (TAR) 48 CFR 1237.110(a), insert the following clause: Qualifications of Contractor Employees (APR 2005) a. Definitions. As used in this clause...
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Clearance of contractor... Clauses 2452.237-75 Clearance of contractor personnel. As prescribed in 2437.110(e), insert the following clause in solicitations and contracts. Clearance of Contractor Personnel (OCT 1999) (a) General. This...
... 6 Domestic Security 1 2010-01-01 2010-01-01 false Government contractor Defense. 25.8 Section 25.8...-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.8 Government contractor Defense. (a) Criteria for... applicability of the government contractor defense. In determining whether to issue such Certification, the...
... Contractor Recruitment Standards AGENCY: Employment and Training Administration, Labor. ACTION: Notice... issuing this notice to announce the recruitment standards that construction contractors are required to... contractors engaged in construction projects related to the realignment of U.S. military forces from Okinawa...
... 7 Agriculture 15 2010-01-01 2010-01-01 false Access to contractor records. 3015.183 Section 3015... contractor records. The Attachment 0 requires recipients to include in specified kinds of contracts a provision for access to the contractor's records by the recipient and the Federal government. The following...
... Contractor. 52.236-6 Section 52.236-6 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....236-6 Superintendence by the Contractor. As prescribed in 36.506, insert the following clause: Superintendence by the Contractor (APR 1984) At all times during performance of this contract and until the work...
..., prior to such employee's engagement in any activity enumerated in section 3(6) of the Act. A farm labor... farm labor contractor employee. 500.41 Section 500.41 Labor Regulations Relating to Labor (Continued... PROTECTION Registration of Farm Labor Contractors and Employees of Farm Labor Contractors Engaged in Farm...
A fundamental premise of the Nuclear Regulatory Commission's (NRC) licensing and inspection program is that licensees are responsible for the proper construction and safe and efficient operation of their nuclear power plants. The total government-industry system for the inspection of commercial nuclear facilities has been designed to provide for multiple levels of inspection and verification. Licensees, contractors, and vendors each participate in a quality verification process in compliance with requirements prescribed by the NRC's rules and regulations (Title 10 Code of Federal Regulations). The NRC performs an overview of the commercial nuclear industry by inspection to determine whether its requirements are being met by licensees and their contractors, while the major inspection effort is performed by the industry within the framework of ongoing quality verification programs
Keeping pace with recent advances in construction technology is a challenge for the cost estimating engineer. Using an estimating style that simulates the actual construction process and is similar in style to the contractor's estimate will give a realistic view of underground construction costs. For a contractor-style estimate, a mining method is chosen; labor crews, plant and equipment are selected, and advance rates are calculated for the various phases of work which are used to determine the length of time necessary to complete each phase of work. The durations are multiplied by the cost or labor and equipment per unit of time and, along with the costs for materials and supplies, combine to complete the estimate. Variations in advance rates, ground support, labor crew size, or other areas are more easily analyzed for their overall effect on the cost and schedule of a project. 14 figs
Salmen, Marcus; Ewy, Gordon A; Sasson, Comilla
To determine whether the use of cardiocerebral resuscitation (CCR) or AHA/ERC 2005 Resuscitation Guidelines improved patient outcomes from out-of-hospital cardiac arrest (OHCA) compared to older guidelines. Systematic review and meta-analysis. MEDLINE, EMBASE, Web of Science and the Cochrane Library databases. We also hand-searched study references and consulted experts. Design: randomised controlled trials and observational studies. OHCA patients, age >17 years. 'Control' protocol versus 'Study' protocol. 'Control' protocol defined as AHA/ERC 2000 Guidelines for cardiopulmonary resuscitation (CPR). 'Study' protocol defined as AHA/ERC 2005 Guidelines for CPR, or a CCR protocol. Survival to hospital discharge. High-quality or medium-quality studies, as measured by the Newcastle Ottawa Scale using predefined categories. Twelve observational studies met inclusion criteria. All the three studies using CCR demonstrated significantly improved survival compared to use of AHA 2000 Guidelines, as did five of the nine studies using AHA/ERC 2005 Guidelines. Pooled data demonstrate that use of a CCR protocol has an unadjusted OR of 2.26 (95% CI 1.64 to 3.12) for survival to hospital discharge among all cardiac arrest patients. Among witnessed ventricular fibrillation/ventricular tachycardia (VF/VT) patients, CCR increased survival by an OR of 2.98 (95% CI 1.92 to 4.62). Studies using AHA/ERC 2005 Guidelines showed an overall trend towards increased survival, but significant heterogeneity existed among these studies. We demonstrate an association with improved survival from OHCA when CCR protocols or AHA/ERC 2005 Guidelines are compared to use of older guidelines. In the subgroup of patients with witnessed VF/VT, there was a threefold increase in OHCA survival when CCR was used. CCR appears to be a promising resuscitation protocol for Emergency Medical Services providers in increasing survival from OHCA. Future research will need to be conducted to directly compare AHA/ERC 2010
To better understand the informational needs of non energy-focused contractors, including what information they need to motivate them to become energy-focused, the BARA team studied the type of information provided by the national programs, trade associations, and manufacturers that were researched for the related technical report: Effective Communication of Energy Efficiency. While that report focused on the delivery method, format, and strategy of the information, this study examines the content being put forward.
Liakus, C. [Building Media and the Building America Retrofit Alliance (BARA), Wilmington, DE (United States)
To better understand the informational needs of non-energy focused contractors, including what information they need to motivate them to become energy-focused, the BARA team studied the type of information provided by the national programs, trade associations, and manufacturers that were researched for the related technical report: Effective Communication of Energy Efficiency. While that report focused on the delivery method, format, and strategy of the information, this study examines the content being put forward.
This report outlines findings resulting from a U.S. Department of Energy Building America expert meeting to determine how HVAC companies can transition from a traditional contractor status to a service provider for whole house energy upgrade contracting. IBACOS has embarked upon a research effort under the Building America Program to understand business impacts and change management strategies for HVAC companies. HVAC companies can implement these strategies in order to quickly transition from a 'traditional' heating and cooling contractor to a service provider for whole house energy upgrade contracting. Due to HVAC service contracts, which allow repeat interaction with homeowners, HVAC companies are ideally positioned in the marketplace to resolve homeowner comfort issues through whole house energy upgrades. There are essentially two primary ways to define the routes of transition for an HVAC contractor taking on whole house performance contracting: (1) Sub-contracting out the shell repair/upgrade work; and (2) Integrating the shell repair/upgrade work into their existing business. IBACOS held an Expert Meeting on the topic of Transitioning Traditional HVAC Contractors to Whole House Performance Contractors on March 29, 2011 in San Francisco, CA. The major objectives of the meeting were to: Review and validate the general business models for traditional HVAC companies and whole house energy upgrade companies Review preliminary findings on the differences between the structure of traditional HVAC Companies and whole house energy upgrade companies Seek industry input on how to structure information so it is relevant and useful for traditional HVAC contractors who are transitioning to becoming whole house energy upgrade contractors Seven industry experts identified by IBACOS participated in the session along with one representative from the National Renewable Energy Laboratory (NREL). The objective of the meeting was to validate the general operational
Noynaert, L.; Bruggeman, A.; Cornelissen, R.; Massaut, V.; Rahier, A
The objectives, the programme, and the achievements of SCK-CEN's Site Restoration Department for 2001 are described. Main activities include the decommissioning of the BR3 PWR-reactor as well as other clean-up activities, projects on waste minimisation and the management of spent fuel and the flow of dismantled materials and the recycling of materials from decommissioning activities based on the smelting of metallic materials in specialised foundries. The department provides consultancy and services to external organisations and performs R and D on new techniques including processes for the treatment of various waste components including the reprocessing of spent fuel, the treatment of tritium, the treatment of liquid alkali metals into cabonates through oxidation, the treatment of radioactive organic waste and the reconditioning of bituminised waste products.
Rohr, Jason R; Farag, Aïda M; Cadotte, Marc W; Clements, William H; Smith, James R; Ulrich, Cheryl P; Woods, Richard
Chemical contamination has impaired ecosystems, reducing biodiversity and the provisioning of functions and services. This has spurred a movement to restore contaminated ecosystems and develop and implement national and international regulations that require it. Nevertheless, ecological restoration remains a young and rapidly growing discipline and its intersection with toxicology is even more nascent and underdeveloped. Consequently, we provide guidance to scientists and practitioners on when, where, and how to restore contaminated ecosystems. Although restoration has many benefits, it also can be expensive, and in many cases systems can recover without human intervention. Hence, the first question we address is: “When should we restore contaminated ecosystems?” Second, we provide suggestions on what to restore—biodiversity, functions, services, all 3, or something else—and where to restore given expected changes to habitats driven by global climate change. Finally, we provide guidance on how to restore contaminated ecosystems. To do this, we analyze critical aspects of the literature dealing with the ecology of restoring contaminated ecosystems. Additionally, we review approaches for translating the science of restoration to on-the-ground actions, which includes discussions of market incentives and the finances of restoration, stakeholder outreach and governance models for ecosystem restoration, and working with contractors to implement restoration plans. By explicitly considering the mechanisms and strategies that maximize the success of the restoration of contaminated sites, we hope that our synthesis serves to increase and improve collaborations between restoration ecologists and ecotoxicologists and set a roadmap for the restoration of contaminated ecosystems. PMID:26033665
Aagaard, Annabeth; Eskerod, Pernille; Madsen, Erik Skov
understandings. Still though, many sub-contractors choose not to coordinate informally. The purpose of this paper is to identify drivers that enhance or inhibits informal coordination in projects. A qualitative, explorative case study approach was applied. Fifteen SME sub-contractors within the offshore wind...... are massive. Six drivers which enhance informal coordination and three drivers which inhibit informal coordination among sub-contractors in projects were identified. The findings imply that management in project-oriented organizations can enhance informal coordination across project sub-contractors...... and by facilitating trust building, by emphasizing previous collaboration successes with the sub-contractors and the possibility of future common projects, by being explicit about expectations on informal coordination, and by developing sub-contractor contracts that are not as tight in economic terms, but instead...
The primary objective of the U.S. Environmental Protection Agency's (EPA) efforts to address the indoor radon problem is to reduce radon levels in buildings throughout the country. Achieving the objective requires a nationwide supply of capable radon mitigation contractors. In the Indoor Radon Abatement Act of 1988, Congress authorized EPA to establish a program to evaluate radon mitigation contractors and to provide the information to the public in cooperation with the States. The Radon Contractor Proficiency (RCP) Program was developed to assist States, EPA Regions, local government officials, and the public in selecting contractors who have demonstrated their proficiency in reducing indoor radon levels. The program is managed by the EPA Office of Radiation Programs' Radon Division. Under the voluntary program, radon contractors demonstrate their proficiency by meeting specific Program requirements. Individual contractors who meet these requirements are then listed in periodic RCP Proficiency Reports
The primary objective of the U.S. Environmental Protection Agency's (EPA) efforts to address the indoor radon problem is to reduce radon levels in buildings throughout the country. Achieving this objective requires a nationwide supply of capable radon mitigation contractors. In the Indoor Radon Abatement Act of 1988, Congress authorized EPA to establish a program to evaluate radon mitigation contractors and to provide this information to the public in cooperation with the States. The Radon Contractor Proficiency (RCP) Program was developed to assist States, EPA Regions, local government officials, and the public in selecting contractors who have demonstrated their proficiency in reducing indoor radon levels. The program is managed by the EPA Office of Radiation Programs' Radon Division. Under this voluntary program, radon contractors demonstrate their proficiency by meeting specific Program requirements. Individual contractors who meet these requirements are then listed in the Report
Full Text Available The performance of contractors is known to be a key determinant of client satisfaction.Here, using factor analysis, clients’ satisfaction is defined in several dimensions. Based onclients’ assessment of contractor performance, a number of satisfaction models developedusing the multiple regression (MR technique are presented. The models identify arange of variables encompassing contractor performance, project performance and respondent(i.e. client attributes as useful predictors of satisfaction levels. Contractor performanceattributes were found to be of utmost importance indicating that clientsatisfaction levels are mainly dependent on the performance of the contractor. Furthermore,findings suggest that subjectivity is to some extent prevalent in clients’ performanceassessment. The models demonstrate accurate and reliable predictive power as confirmedby validation tests. Contractors could use the models to help improve their performanceleading to more satisfied clients. This would also promote the development ofharmonious working relationships within the construction project coalition.
The primary objective of the U.S. Environmental Protection Agency's (EPA) efforts to address the indoor radon problem is to reduce radon levels in buildings throughout the country. Achieving the objective requires a nationwide supply of capable radon mitigation contractors. In the Indoor Radon Abatement Act of 1988, Congress authorized EPA to establish a program to evaluate radon mitigation contractors and to provide the information to the public in cooperation with the States. The Radon Contractor Proficiency (RCP) Program was developed to assist States, EPA Regions, local government officials, and the public in selecting contractors who have demonstrated their proficiency in reducing indoor radon levels. The program is managed by the EPA Office of Radiation Programs' Radon Division. Under the voluntary program, radon contractors demonstrate their proficiency by meeting specific Program requirements. Individual contractors who meet these requirements are then listed in the Report
Frazier, Christopher Rawls; Durfee, Justin David; Bandlow, Alisa; Gearhart, Jared Lee; Jones, Katherine A
The Contingency Contractor Optimization Tool – Prototype (CCOT-P) database is used to store input and output data for the linear program model described in . The database allows queries to retrieve this data and updating and inserting new input data.
Hurricane Andrew's long term effect on Gulf of Mexico oil and gas operations likely won't be known until next year. This paper reports that while damage assessments have moved beyond the emergency stage, many offshore service companies say reliable estimates of the extent of damage or cost of repairs still are unavailable. The time needed to complete restorations won't be known conclusively until more organized surveys are complete. Even then, many contractors say, gulf operators must decide how to handle damage at each location-whether to repair damaged structures or replace them by applying technology not available when many of the fields were developed. Some damaged installations will not be replaced or restored, and the production will be lost
Abilio Donizetti de Morais Filho
Full Text Available The objective of this study was to describe the financial conditions of forestry contractors, concerning life quality aspects, condition of work and equipments, operational costs, and economic credit to invest in new technologies. Five companies had been analyzed, with an annual income between US$ 400,000.00 and US$ 1,720,000.00, with an average of US$ 950,000.00. The number of employees varied between 33 and 181, and the companies were classified in terms of size as: one small, two average, and two big. The main difficulties to invest in new machines were high financial taxes, more than 12% an year, and a lack of long term contracts to guarantee the payment capability. It was observed that the contractors did not consider the capital remuneration and a correct depreciation of machines, resulting in an average machine life higher than 10 years. The final conclusions were that the costs were above the paid values for the services, when computed the depreciation and capital remuneration, with negative results in the financial analyzes of three companies. Finally, the mechanization process increased the workers life quality, however, the annual income was around US$ 2,112.00 per worker, approximately 39% lower than the average Brazilian population.
The Technical Assistance Contractor (TAC) for the Uranium Mill Tailings Remedial Action (UMTRA) Project comprises Jacobs Engineering Group Inc. (JEG) as the prime contractor and three teaming partner subcontractors: Roy F. Weston, Inc. (RFW), AGRA Earth and Environmental, Inc. (AGRA), and Geraghty and Miller, Inc. (G and M). The TAC contract's scope is to provide technical, analytical, environmental, engineering, design, inspection, and management support services to the US Department of Energy (DOE) for both Surface and Ground Water Projects. The TAC team supports the DOE in completing surface remedial action and initiating ground water remediation work for start-up, characterization, compliance planning, design, construction oversight, and remedial operations. The TAC provides the DOE UMTRA Project Team with a dedicated management, scientific, and technical resource base in Albuquerque, New Mexico, which is supplemented by corporate resources. A carefully developed and maintained staff of technical experts is available to assess, analyze, develop, and execute cost-effective solutions to the demanding technical and institutional problems presented by the UMTRA Project
The Technical Assistance Contractor (TAC) for the Uranium Mill Tailings Remedial Action (UMTRA) Project comprises Jacobs Engineering Group Inc. (JEG) as the prime contractor and three teaming partner subcontractors: Roy F. Weston, Inc. (RFW), AGRA Earth and Environmental, Inc. (AGRA), and Geraghty and Miller, Inc. (G and M). The TAC contract`s scope is to provide technical, analytical, environmental, engineering, design, inspection, and management support services to the US Department of Energy (DOE) for both Surface and Ground Water Projects. The TAC team supports the DOE in completing surface remedial action and initiating ground water remediation work for start-up, characterization, compliance planning, design, construction oversight, and remedial operations. The TAC provides the DOE UMTRA Project Team with a dedicated management, scientific, and technical resource base in Albuquerque, New Mexico, which is supplemented by corporate resources. A carefully developed and maintained staff of technical experts is available to assess, analyze, develop, and execute cost-effective solutions to the demanding technical and institutional problems presented by the UMTRA Project.
... of Federal Contract Compliance Programs (OFCCP). Federal law and an executive order place greater responsibilities on federal contractors compared with other employers In some areas of workplace activity...
Lier, K.H. [ExxonMobil Production Deutschland GmbH, Hannover (Germany)
Reliable and efficient contractors are important for the activities of ExxonMobil. Qualification of contractors is to ensure that contractors provide technical services in accordance with the specifications of ExxonMobil. Apart from the financial, oranisational and legal qualification this covers technical qualification, i.e. industrial safety, health protection and environmental protection, as well as technical efficiency and quality. The ultimate intention is to find out if contractors have the processes and systems at their disposal that are required for the services. The qualification process is described. (orig.)
.... Furthermore, this paper also lists four recommendations for operational commanders and the military on how to better integrate contractors into the military effort, especially during hostile combat situations...
This directory was developed by the Office of Environmental Guidance, RCRA/CERCLA Division (EH-231) from an outgrowth of the Departments efforts to identify and establish the regulatory response lead persons in the Field Organizations. The directory was developed for intemal EH-231 use to identify both the DOE and DOE contractor Field Organizations in the Environment, Environmental Restoration and Waste Management areas. The Field Organization directory is divided into three substantive sections: (1) Environment; (2) Environmental Restoration; and (3) Waste Management which are organized to correspond to the management hierarchy at each Field Organization. The information provided includes the facility name and address, individual managers name, and telephone/fax numbers
Korzeniewska, Anna; Franaszczuk, Piotr J; Crainiceanu, Ciprian M; Kuś, Rafał; Crone, Nathan E
Intracranial EEG studies in humans have shown that functional brain activation in a variety of functional-anatomic domains of human cortex is associated with an increase in power at a broad range of high gamma (>60Hz) frequencies. Although these electrophysiological responses are highly specific for the location and timing of cortical processing and in animal recordings are highly correlated with increased population firing rates, there has been little direct empirical evidence for causal interactions between different recording sites at high gamma frequencies. Such causal interactions are hypothesized to occur during cognitive tasks that activate multiple brain regions. To determine whether such causal interactions occur at high gamma frequencies and to investigate their functional significance, we used event-related causality (ERC) analysis to estimate the dynamics, directionality, and magnitude of event-related causal interactions using subdural electrocorticography (ECoG) recorded during two word production tasks: picture naming and auditory word repetition. A clinical subject who had normal hearing but was skilled in American Signed Language (ASL) provided a unique opportunity to test our hypothesis with reference to a predictable pattern of causal interactions, i.e. that language cortex interacts with different areas of sensorimotor cortex during spoken vs. signed responses. Our ERC analyses confirmed this prediction. During word production with spoken responses, perisylvian language sites had prominent causal interactions with mouth/tongue areas of motor cortex, and when responses were gestured in sign language, the most prominent interactions involved hand and arm areas of motor cortex. Furthermore, we found that the sites from which the most numerous and prominent causal interactions originated, i.e. sites with a pattern of ERC "divergence", were also sites where high gamma power increases were most prominent and where electrocortical stimulation mapping
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Follow-up by contractor....305-2 Follow-up by contractor. (b) Contractor reports. Contractors shall complete and submit to the... Contracting Officer shall send the form to those contractors whose contract work may have required the...
... Contractor Registration AGENCY: Department of Defense (DoD), General Services Administration (GSA), and... changes the clauses requiring contractor registration in the Central Contractor Registration (CCR... unique identifier for contractors. It is used (1) to uniquely identify a contractor entity, and (2) to...
This special Petroleum Economist Sponsored Supplement looks at the present condition and future prospects of the Russian oil and gas industry. Russia's chief oil and gas contractor, Rosneftegazstroy, a joint stock company formed in 1991, took over from the former Soviet Union's Ministry of Oil and Gas Construction and from Neftegazstroy, the State concern. Responsible for the exploration and exploitation of the country's huge oil and gas reserves, Rosneftegazstroy has a mammoth task ahead to modernize and create an adequate infrastructure for its new commercial basis. Its foreign investment projects are described and plans for rebuilding and new developments are discussed. Russia's fuel and energy industries now show clear signs of increasing activity, amid a backdrop of falling production overall. (UK)
Caron, G [Pe Ben Pipelines Ltd.; Osadchuk, V; Sharp, M; Stabback, J G
A discussion of papers presented at a Pipe Line Contractors Association of Canada convention includes comments by G. Caron (Pe Ben Pipelines Ltd.) on the continued slack in big-inch pipeline construction into 1980 owing mainly to delayed U.S. and Canadian decisions on outstanding Alaska Highway gas pipeline issues and associated gas export bids and on the use of automatic welding for expeditious construction of the northern sections of the Alaska Highway pipeline; by V. Osadchuk (Majestic Wiley Contract. Ltd.) on the liquidation of surplus construction equipment because of these delays; by M. Sharp (Can. North. Pipeline Agency) on the need for close U.S. and Canadian governmental and industrial cooperation to permit an early 1980 start for construction of the prebuild sections of the Alaska pipeline; and by J. G. Stabback (Can. Natl. Energy Board) on the Alaska oil pipeline applications by Foothills Pipe Lines Ltd., Trans Mountain Pipe Line Co. Ltd., and Kitimat Pipe Line Ltd.
Contractor Selection for Enhancing the Quality of University Education in Nigeria using the Hamming Distance. DEA Omorogbe, SO Aibieyi. Abstract. The need for contractor selection in our university education system cannot be over emphasized. And applying scientific techniques for appropriateness and accuracy in the ...
Singletary, Tod J.
The United States Military has become increasingly dependent upon technology to meet its mission objectives with a consequence being greater dependence on civilian defense contractors to provide specialized services in support of high-tech mission requirements. Modern military defense contractors have also become dependent upon reliable and secure…
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contractor records retention. 970.0407 Section 970.0407 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Administrative Matters 970.0407 Contractor...
Koch, Christian; Frödell, M.; Josephson, P.E.
by the Erabuild program, this paper presents 3 cases of long term transformation of contractor- supplier relations as general contractors outsource and commence professionalising purchasing moving it from project purchasing into strategic purchasing. It is suggested that “new industrialisation” is a long term...
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor Personnel Security Program. 2804.470 Section 2804.470 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE General ADMINISTRATIVE MATTERS Safeguarding Classified Information Within Industry 2804.470 Contractor...
... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Contractor acquired property. 1274.402 Section 1274.402 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION COOPERATIVE AGREEMENTS WITH COMMERCIAL FIRMS Property § 1274.402 Contractor acquired property. As provided in § 1274.923...
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Evaluation of contractor performance. 36.201 Section 36.201 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Contracting for Construction 36.201 Evaluation of contractor performance. See 42.1502(e) for the requirements...
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Completion by another contractor. 49.405 Section 49.405 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... contractor. If the surety does not arrange for completion of the contract, the contracting officer normally...
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor inspection requirements. 1646.301 Section 1646.301 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT... Clauses 1646.301 Contractor inspection requirements. The clause set forth at 1652.246-70 shall be inserted...
... DEPARTMENT OF ENERGY 48 CFR Part 952 RIN 1990-AA37 Contractor Legal Management Requirements; Acquisition Regulations; Correction AGENCY: Department of Energy. ACTION: Final rule; correction. SUMMARY: The... (78 FR 25795). In this document, DOE revised existing regulations covering contractor legal management...
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contractor qualification requirements. 1437.7001 Section 1437.7001 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR... Contractor qualification requirements. (a) Prior to award of a contract for real property appraisal services...
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Restrictions on contractor advertising. 1403.570 Section 1403.570 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR... 1403.570 Restrictions on contractor advertising. ...
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Telecommuting of... Telecommuting of contractor employees. (a) SOWs/PWSs shall permit offerors or contractors to specify their own... telecommuting) for any part of an SOW/PWS, after determining that the work or any portion thereof must be...
... licensing contractors, who may bid for, be awarded, or perform Federal-aid highway contracts, shall be... competition, to prevent submission of a bid by, or to prohibit the consideration of a bid submitted by, any...) No contractor shall be required by law, regulation, or practice to obtain a license before submission...
Full Text Available In this paper the author analyzes a civil law responsibility of the Contractor for project deficiencies resulting in reduced quality of the construction, i.e. not affecting its solidity. Primary obligation of the Contractor is to perform works in compliance with professional standards, the contract and the approved project. The Contractor cannot change the approved project at will, even when he has designed it. Hence, the question must be raised of the obligation of the Contractor to strictly abide by the project, assigned to him by the Authority, regardless of evident deficiencies of the Project and of his responsibility for performing works in compliance with the said project resulting in deficiencies in the construction, that is construction works. If the latter hypothesis is correct, then it must be established what deficiencies in the project fall under the responsibility of the Contractor (visible or hidden, i.e. the issue of dividing responsibility between the Project Designer and the Contractor in terms of the project deficiencies must be set up and solved. Finally, it is also important to define the realization of rights and duties of the Contractor in case the Contractor has to recede from the Project. In this paper the author tries to offer detail and complete answers to raised questions.
... repositories. 227.7108 Section 227.7108 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Technical Data 227.7108 Contractor data repositories. (a) Contractor data repositories may be established when permitted by agency procedures. The contractual instrument establishing the data repository must...
This paper reports that the Environmental Protection Agency (EPA) has developed a voluntary program to evaluate radon reduction contractors and provide this information to the public, as part of activities mandated by the Indoor Radon Abatement Act (IRAA) of 1988. The Radon Contractor Proficiency Program consists of several elements that collectively help to ensure the proficiency of radon mitigators and give the public greater confidence in their capability. Contractors who participate in the program must pass a written examination, adhere to mitigation guidelines, keep records of work, meet continuing education requirements and pass a re-examination every two years. Upon meeting the program's requirements, mitigators are listed in EPA's National RCP Proficiency Report. The first Report released on May 15, 1990 listed 636 contractors. The second Report, to be release in August, will list 895 contractors, representing an increase of 40 per cent
The report, a supplement to the RCP Proficiency Report, will further assist governmental officials in providing advice to the public on the selection of proficient radon mitigation contractors. These reports list 1,123 contractors who have met the requirements of the RCP Program as of December 15, 1990. The Proficiency Report provides information on each contractor's name, RCP identification number, company name, address, phone number, and geographic service area. The report provides two additional tables, indexed by company name and by RCP identification number. The report is intended to help users quickly identify a proficient contractor if only the company name is known, or to verify which contractor is associated with a particular ID number
Macarena De los Santos-Roig
Full Text Available La Escala sobre Representación Cognitiva de la Enfermedad, ERCE (De los Santos-Roig, 2009 ha sido elaborada para evaluar las creencias de los pacientes sobre su enfermedad. El modelo de Sentido Común, donde se inserta el constructo, ha sido puesto a prueba en numerosas ocasiones, encontrándose evidencia sobre la importancia de la Representación Cognitiva en los procesos de adaptación a la enfermedad (Hagger y Orbell, 2003; Leventhal et al., 1997. Su medida en nuestro ámbito cultural es necesaria, tanto desde un punto de vista teórico, como desde una perspectiva aplicada. Lo que aquí se muestra es la continuación a un trabajo previo (De los Santos-Roig, 2009; De los Santos-Roig y Pérez-Meléndez, 2013 donde se concretó la definición semántica del constructo RCE y las Tablas de Especificaciones del Test y de los Ítems, que finalmente culminó con la presentación de los primeros ítems construidos. Siguiendo con lo establecido en los estándares (AERA, APA y NCME, 1999, se muestran ahora los resultados del análisis estadístico de los ítems correspondientes a las cinco escalas que componen la ERCE, así como los obtenidos sobre sus evidencias de fiabilidad. Al final, se concluye sobre la idoneidad de los ítems que conforman la escala.
...; Information Collection; Contractors' Purchasing Systems Reviews AGENCY: Department of Defense (DOD), General... collection requirement concerning contractors' purchasing systems reviews. Public comments are particularly... Information Collection 9000- 0132, Contractors' Purchasing Systems Reviews, by any of the following methods...
...; Information Collection; Contractor Business Ethics Compliance Program and Disclosure Requirements AGENCIES... concerning contractor business ethics compliance program and disclosure requirements. Public comments are... Collection 9000- 0164, Contractor Business Ethics Compliance Program and Disclosure Requirements, by any of...
...; Information Collection; Contractor Use of Interagency Fleet Management System Vehicles AGENCY: Department of... previously approved information collection requirement concerning contractor use of interagency fleet... Collection 9000- 0032, Contractor Use of Interagency Fleet Management System Vehicles, by any of the...
...; Submission for OMB Review; Contractor Use of Interagency Fleet Management System Vehicles AGENCY: Department... previously approved information collection requirement concerning contractor use of interagency fleet... comments identified by Information Collection 9000- 0032, Contractor Use of Interagency Fleet Management...
...; Information Collection; Central Contractor Registration AGENCIES: Department of Defense (DOD), General... collection requirement concerning the Central Contractor Registration database. A notice was published in the... Information Collection 9000- 0159, Central Contractor Registration, by any of the following methods...
...] Information Collection; Central Contractor Registration Requirements for Prime Grant Recipients AGENCY: Office... information collection requirement regarding Central Contractor Registration Requirements for Prime Grant... for the proper performance of functions of the Central Contractor Registration Requirements for Prime...
... Federal Acquisition Regulation; Updates to Contract Reporting and Central Contractor Registration AGENCIES... Procurement Data System (FPDS). Additionally, changes are proposed for the clauses requiring contractor registration in the Central Contractor Registration (CCR) database and DUNS number reporting. DATES: Interested...
... of the Chief Information Officer; Submission for OMB Review; Temporary Contractor Information... information collection requirement regarding temporary contractor information worksheet. A notice was... for temporary contractors as a result of the American Recovery and Reinvestment Act of 2009 (Public...
... Proposed Information Collection to OMB; Contractor's Requisition--Project Mortgages AGENCY: Office of the.... Contractor's monthly application for distribution of insured mortgage proceeds for construction costs... Following Information Title of Proposal: Contractor's Requisition--Project Mortgages. OMB Approval Number...
...; Submission for OMB Review; Contractor Business Ethics Compliance Program and Disclosure Requirements AGENCIES... contractor business ethics compliance program and disclosure requirements. Public comments are particularly... Information Collection 9000- 0164, Contractor Business Ethics Compliance Program and Disclosure Requirements...
...; Information Collection; Central Contractor Registration AGENCY: Department of Defense (DOD), General Services... requirement concerning the Central Contractor Registration database. Public comments are particularly invited... Information Collection 9000- 0159, Central Contractor Registration, by any of the following methods...
... Information Collection; Independent Contractor Registration and Identification AGENCY: Mine Safety and Health...-00040, Independent Contractor Register. OMB last approved this information collection request (ICR) on...); or 202-693-9441 (facsimile). SUPPLEMENTARY INFORMATION: I. Background Independent contractors...
Little, C.C.; Kozlowski, D.R.
This paper will present a description of the program undertaken by the Fernald Environmental Restoration Management Contractor (ERMC) to effect a transition from operation of the Fernald site by the past M ampersand O contractor, WEMCO, to DOE's new mission and contractual approach focussed on site remediation. This transition, on a first of its kind contract, represented a significant, proactive approach on the part of DOE to pursue the clean up of its weapon's production facilities in a faster, more cost-effective manner. The paper will discuss the formal transition readiness review process and the lessons teamed by DOE and the contractor during transition. The oral presentation will be shared by both authors with one half of the time allocated to the transition readiness demonstration process and one half to the lessons learned. The objective of having a Department of Energy (DOE) Headquarters representative participate in the transition to the first ERMC was to develop a handbook to assist other sites proceeding with the ERMC concept, such as the Richland Operations Office, and to develop a lessons learned document. Because a lessons learned report is available separately, only those more significant lessons learned are highlighted in this paper
The report lists those individual contractors in the United States who have met the requirements of the Radon Contractor Proficiency (RCP) Program as of August 18, 1990. These requirements are designed to provide minimum proficiency criteria for individuals who design and supervise the installation of radon mitigation systems in buildings. (Some States have more stringent requirements as part of their radon certification programs. The States should be consulted directly for details on their programs; see Section 5 for a list of State radon contacts). The RCP Program measures the proficiency of an individual contractor, not their company. Therefore, users of the report who select a mitigation firm should ensure that the services are provided by the listed contractor. The National RCP Program does not accredit mitigation contractors, nor does it certify, recommend, or endorse participating companies. Only the listed contractor, not their company of affilation, are deemed proficient. The inclusion of a contractor in the report should not be interpreted as a certification or accreditation of the individual or affiliated company
Jonathan W. Long
Grazing exclusion and channel modifications were used to restore wet meadows along a stream on the Fort Apache Indian Reservation. The efforts are reestablishing functional processes to promote long-term restoration of wetland health and species conservation.
pollution exclusion was completely modified. The new standard exclusion reads: 1988 ISO POLLUTION EXCLUSION f. (7) "Bodily injury" or "property damage...which are pertinent to the defense thereof. 0 20 * REYNOLDS METALS COMPANY P.O. Box 27003 • Richmond. Vginia 23261-7003 24 August 1993 Office of the
The Technical Assistance Contractor (TAC) for the Uranium Mill Tailings Remedial Action (UMTRA) Project comprises Jacobs Engineering Group Inc. (JEG) and its major teaming partners [Roy F. Weston, Inc. (RFW), Sergent, Hauskins & Beckwith Agra, Inc. (SHB Agra), and Geraghty & Miller, Inc. (G&M)]. The first three companies have worked together effectively on the UMTRA Project for more than 10 years. With the initiation of the UMTRA Groundwater Project in April 1991, a need arose to increase the TAC`s groundwater technical breadth and depth, so G&M was brought in to augment the team`s capabilities. The TAC contract`s scope is to provide technical, analytical, environmental, engineering, design, inspection, and management support services to the US Department of Energy (DOE) for both surface and groundwater projects. The TAC team continues to support the DOE in completing surface remedial actions and initiating groundwater remediation work for start-up, characterization, design, construction oversight, and remedial operations. A key feature of the TAC`s management approach is the extensive set of communication systems implemented for the UMTRA Project. These systems assist all functional disciplines in performing UMTRA Project tasks associated with management, technical support, administrative support, and financial/project controls.
Government contractors, particularly those involved with hazardous waste response action activities, are encountering increased risks for environmental tort liabilities. Contracts often include tasks and work assignments requiring the management of industrial, chemical, nuclear or mining wastes, spent fuels, munitions or other toxic substances. Contractors exposure to liability for damages results directly from the environmental laws and regulations pursuant to which the Government has contracted them to respond. Additionally, contractors may be exposed to common law liability under such dogmas as nuisance, trespass and strict liability in tort
Mohamad Rahim Ramezaniyan
Full Text Available Contractor selection is a critical activity, which plays an important role in the overall success of any construction project. The implementation of fuzzy multiple criteria decision attribute (MCDA in selecting contractors has the advantage of rendering subjective and implicit decision making more objective and transparent. An additional merit of fuzzy MCDA is the ability to accommodate quantitative and qualitative information. In this paper, an integrated VIKOR–AHP methodology is proposed to make a selection among the alternative contractors in one of Iranian construction industry projects. In the proposed methodology, the weights of the selection criteria are determined by fuzzy pairwise comparison matrices of AHP.
Fernandez, Miguel; Garcia, Monica; Fernandez, Nestor
The Global ecosystem restoration index (GERI) is a composite index that integrates structural and functional aspects of the ecosystem restoration process. These elements are evaluated through a window that looks into a baseline for degraded ecosystems with the objective to assess restoration...
Lithgow, D.; Martínez, M. L.; Gallego-Fernández, J. B.; Hesp, P. A.; Flores, P.; Gachuz, S.; Rodríguez-Revelo, N.; Jiménez-Orocio, O.; Mendoza-González, G.; Álvarez-Molina, L. L.
Restoration and preservation of coastal dunes is urgently needed because of the increasingly rapid loss and degradation of these ecosystems because of many human activities. These activities alter natural processes and coastal dynamics, eliminate topographic variability, fragment, degrade or eliminate habitats, reduce diversity and threaten endemic species. The actions of coastal dune restoration that are already taking place span contrasting activities that range from revegetating and stabilizing the mobile substrate, to removing plant cover and increasing substrate mobility. Our goal was to review how the relative progress of the actions of coastal dune restoration has been assessed, according to the ecosystem attributes outlined by the Society of Ecological Restoration: namely, integrity, health and sustainability and that are derived from the ecological theory of succession. We reviewed the peer reviewed literature published since 1988 that is listed in the ISI Web of Science journals as well as additional references, such as key books. We exclusively focused on large coastal dune systems (such as transgressive and parabolic dunefields) located on natural or seminatural coasts. We found 150 articles that included "coastal dune", "restoration" and "revegetation" in areas such as title, keywords and abstract. From these, 67 dealt specifically with coastal dune restoration. Most of the studies were performed in the USA, The Netherlands and South Africa, during the last two decades. Restoration success has been assessed directly and indirectly by measuring one or a few ecosystem variables. Some ecosystem attributes have been monitored more frequently (ecosystem integrity) than others (ecosystem health and sustainability). Finally, it is important to consider that ecological succession is a desirable approach in restoration actions. Natural dynamics and disturbances should be considered as part of the restored system, to improve ecosystem integrity, health and
Integrated absolute dating approach for terrestrial records of past climate using trapped charge methods (INTERTRAP) - the blessing and turmoil of implementing for the first time an ERC grant at a Romanian university
Timar-Gabor, Alida; Buylaert, Jan-Pieter
This year marks European Research Council`s (ERC) 10th anniversary. Romania is celebrating as well 10 years as a member state of the European Union. Over the past decade Romania has made significant progress in supporting research development at the national level. However, when it comes to excellent frontier research as supported by the ERC, Romania`s involvement and visibility at a European level remains very low. Considering only young researchers, according to ERC statistics only 142 proposals hosted by institutions in Romania have been submitted in the Starting and Consolidator Grant schemes in the last 3 years (2014-2016). For corresponding funding schemes at a national level Romania`s Executive Agency for Financing Research, Development and Innovation (UEFISCDI) received over 2000 applications only in 2016. The success rate of ERC proposals hosted by Romania is even more concerning (less than 3%) with only 4 projects out of 142 being granted. In 2015, Dr Alida Timar-Gabor was awarded an ERC starting grant (grant agreement No ; INTERTRAP) which is the first ERC project to be implemented in a Romanian university. In the INTERTRAP project Dr Timar-Gabor and her team aims to achieve significant improvement in quartz based luminescence dating and to develop new absolute dating techniques for Quaternary sediments. During the implementation of the project a new state-of-the-art luminescence and electron spin resonance laboratory, unique in Eastern Europe and one of the only two or three in the world, will be set up. Dr. Alida Timar-Gabor, PI of INTERTRAP, is the founder and leader of the only absolute dating laboratory in Romania that was founded in 2008. She has defended her PhD in 2010 and supervised and co-supervised 10 other PhD students since then. She holds various national and international awards. Her career path has been significantly influenced by a strong network of international collaborations. In this presentation she will give an overview of
.... An increased reliance on contractor support has helped ease the burden on a heavily reduced force structure, but has left military commanders vulnerable to declaring a non-mission capable status during times of crisis...
Separate abstracts was prepared for each of the 62 papers presented at the Contractors' Coordination meeting on highway vehicle systems. One paper had previously appeared in DOE's data base.
.... Generally, two or more companies form a team by negotiating an agreement to work together to pursue a particular government procurement, with one company acting as the primary contractor and others as subcontractors...
Powmya, Ayisha; Abidin, Nazirah Zainul; Azizi, Nurul Sakina Mokhtar
Building green requires effort from various parties, from those who plan, design, manage and construct the building. Contractors are responsible for converting the design on paper into a real building and their role at the construction site support environmental sustainability by implementing responsible construction practices. Inefficient or inexperienced contractor in green construction project may find that delivering this type of project is not an easy task due to added requirement in design, stringent practices at site and the use of green technology and materials. Adopting suitable strategies at firm level will assist in preparatory process and readiness of delivering the green project. This paper reviews the strategies at firm level to deliver green construction project. From extensive literature review, it was discovered that there are six strategies to be adopted by the contractor. Understanding these strategies is expected to promote more contractors to be proactive in delivering green projects.
Frisk, Daniel; Trunkey, R. D; Talaber, Adam; Adedeji, Adebayo; Liu, Victoria; Dennis, Robert; Gullo, Theresa; Sammartino, Frank; Murphy, Robert; Elsea, Jennifer
.... This paper, which covers the period from 2003 through 2007, provides an overview of the federal costs of employing contractors in Iraq and in nearby countries, the type of products and services...
... on nor diverted to another job; and (iii) A fabrication period of more than 6 months is anticipated...: (i) A first payment upon submission by the prime contractor of shop drawings for the equipment or...
Warren, David R; Bianco, Michael A; Nasser, Waheed; Kusman, Richard R; Shafer, James; Venner, Jason; Walls, Lovell Q; Wright, Samson J
Section 842 of the National Defense Authorization Act of 2008 (Public Law 110-181), required SIGIR to, among other things, develop a plan to evaluate various characteristics of contracting for private security contractor services in Iraq...
The NASA/Contractor Team efforts are presented as part of NASA's continuing effort to facilitate the sharing of quality and productivity improvement ideas among its contractors. This complilation is not meant to be a comprehensive review of contractor initiative nor does it necessarily express NASA's views. The submissions represent samples from a general survey, and were not edited by NASA. The efforts are examples of quality and productivity programs in private industry, and as such, highlight company efforts in individual areas. Topics range from modernization of equipment, hardware, and technology to management of human resources. Of particular interest are contractor initiatives which deal with measurement and evaluation data pertaining to quality and productivity performance.
Mikhail Yu. POPOV
This article is devoted to the analysis of an essence of the concept "contractors of socialization" and attempt of definition of its place in structure of sociological knowledge. During the solution of this task the author seeks to define destructive nature of influence of contractors of socialization on formation of the personality both at a stage of primary socialization, and in the course of the entire period of its activity. Inclusion of this term in structure of sociological knowledge, a...
The Human Resources Staffing Plan quantified the equivalent staffing needs required for the Tank Farm Contractor (TFC) and its subcontractors to execute the readiness to proceed baseline between FY 2000-2008. The TFC staffing needs were assessed along with the staffings needs of Fluor Hanford and the privatization contractor. The plan then addressed the staffing needs and recruitment strategies required to execute the baseline
Mazaheri, Yousef; Vargas, H. Alberto; Nyman, Gregory; Shukla-Dave, Amita; Akin, Oguz; Hricak, Hedvig
Purpose: To compare ADC values measured from diffusion-weighted MR (DW-MR) images of the prostate obtained with both endorectal and phased-array coils (ERC + PAC) to those from DW-MRI images obtained with an eight-channel torso phased-array coil (PAC) at 3.0 T. Methods: The institutional review board issued a waiver of informed consent for this HIPAA-compliant study. Twenty-five patients with biopsy-proven prostate cancer underwent standard 3-T MRI using 2 different coil arrangements (ERC + PAC and PAC only) in the same session. DW-MRI at five b-values (0, 600, 1000, 1200, and 1500 s/mm 2 ) were acquired using both coil arrangements. On b = 0 images, signal-to-noise ratios (SNRs) were measured as the ratio of the mean signal from PZ and TZ ROIs to the standard deviation from the mean signal in an artifact-free ROI in the rectum. Matching regions-of-interest (ROIs) were identified in the peripheral zone and transition zone on ERC-MRI and PAC-MRI. For each ROI, mean ADC values for all zero and non-zero b-value combinations were computed. Results: Mean SNR with ERC-MRI at PZ (66.33 ± 27.07) and TZ (32.69 ± 12.52) was 9.27 and 5.52 times higher than with PAC-MRI ((7.32 ± 2.30) and (6.13 ± 1.56), respectively) (P < 0.0001 for both). ADCs from DW-MR images obtained with all b-values in the PZ and TZ were significantly lower with PAC-MRI than with ERC-MRI (P < 0.001 for all). Conclusion: Lower SNR of DW-MR images of the prostate obtained with a PAC can significantly decrease ADC values at higher b-values compared to similar measurements obtained using the ERC. To address these requirements, clinical MR systems should have image processing capabilities which incorporate the noise distribution
... 42 Public Health 2 2010-10-01 2010-10-01 false Appeals of CMS or a CMS contractor. 405.874 Section... Part B Program § 405.874 Appeals of CMS or a CMS contractor. A CMS contractor's (that is, a carrier... supplier enrollment application. If CMS or a CMS contractor denies a provider's or supplier's enrollment...
...-AL92 Federal Acquisition Regulation; Oversight of Contractor Ethics Programs AGENCY: Department of... that contractors have implemented the mandatory contractor business ethics program requirements. DATES... to Improve DoD's Oversight of Contractor Ethics Programs. The ethics program requirement flows from...
... Number 0750-AG38 Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access... Government support contractors to have access to proprietary technical data belonging to prime contractors and other third parties, provided that the technical data owner may require the support contractor to...
...-AG52 Defense Federal Acquisition Regulation Supplement (DFARS); Continuation of Essential Contractor... that contractors providing essential contractor services, as determined by the requiring activity..., implementing the requirements of DoDI 3020.37, Continuation of Essential DoD Contractor Services During Crises...
... labor contractors' recruitment, contractual and general obligations. The Act imposes certain specific recruitment, contractual and general obligations on farm labor contractors and farm labor contractor employees... 29 Labor 3 2010-07-01 2010-07-01 false Farm labor contractors' recruitment, contractual and...
... Provisions and Clauses 1852.242-73 NASA contractor financial management reporting. As prescribed in 1842.7202, insert the following clause: NASA Contractor Financial Management Reporting (NOV 2004) (a) The Contractor... instructions in NASA Procedures and Guidelines (NPR) 9501.2, NASA Contractor Financial Management Reporting...
Durfee, Justin David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Frazier, Christopher Rawls [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bandlow, Alisa [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gearhart, Jared Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Katherine A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sandia National Laboratories (Sandia) is in Phase 3 Sustainment of development of a prototype tool, currently referred to as the Contingency Contractor Optimization Tool - Prototype (CCOTP), under the direction of OSD Program Support. CCOT-P is intended to help provide senior Department of Defense (DoD) leaders with comprehensive insight into the global availability, readiness and capabilities of the Total Force Mix. The CCOT-P will allow senior decision makers to quickly and accurately assess the impacts, risks and mitigating strategies for proposed changes to force/capabilities assignments, apportionments and allocations options, focusing specifically on contingency contractor planning. During Phase 2 of the program, conducted during fiscal year 2012, Sandia developed an electronic storyboard prototype of the Contingency Contractor Optimization Tool that can be used for communication with senior decision makers and other Operational Contract Support (OCS) stakeholders. Phase 3 used feedback from demonstrations of the electronic storyboard prototype to develop an engineering prototype for planners to evaluate. Sandia worked with the DoD and Joint Chiefs of Staff strategic planning community to get feedback and input to ensure that the engineering prototype was developed to closely align with future planning needs. The intended deployment environment was also a key consideration as this prototype was developed. Initial release of the engineering prototype was done on servers at Sandia in the middle of Phase 3. In 2013, the tool was installed on a production pilot server managed by the OUSD(AT&L) eBusiness Center. The purpose of this document is to specify the CCOT-P engineering prototype platform requirements as of May 2016. Sandia developed the CCOT-P engineering prototype using common technologies to minimize the likelihood of deployment issues. CCOT-P engineering prototype was architected and designed to be as independent as possible of the major deployment
This report was prepared in response to a recommendation by the IAEA International Working Group on Training and Qualification of NPP Personnel (JWG-T and Q) and supported by a number of IAEA meetings on NPP personnel training. IAEA publications on NPP training are the only international documents available to all Member States with nuclear programmes. This report complements the following IAEA publications on NPP personnel training: Technical Reports Series No. 380, Nuclear Power Plant Personnel Training and its Evaluation, A Guidebook; IAEA-TECDOC-1057, Experience in the Use of Systematic Approach to Training (SAT) for Nuclear Power Plant Personnel and IAEA-TECDOC-1063, IAEA World Survey on Nuclear Power Plant Personnel Training. This TECDOC also supplements the IAEA Safety Guide 50-SG-O1 (Rev. 1), Staffing of Nuclear Power Plants and the Recruitment Training and Authorization of Operating Personnel and Safety Standards Series No. NS-R-2, Safety of Nuclear Power Plants. Operation. Within the context of this report NPP contractors are defined as any personnel working for a nuclear power plant who are not directly employed by the nuclear power plant. Competence is the ability to perform to identified standards; it comprises skills, knowledge and attitudes and may be developed through education, experience and training. Qualification is a formal statement of achievement, resulting from an auditable assessment; if competence is assessed, the qualification becomes a formal statement of competence and may be shown on a certificate, diploma, etc. It is recognized that personnel are used to perform tasks that are of a specialised or temporary nature where it is not feasible to hire or maintain a full-time NPP employee. Accordingly, contractors may be used in a variety of situations to support NPPs. Typical situations include: supplies and services being delivered by the contractors that are subject to different quality standards based on a graded approach to assuring
This report was prepared in response to a recommendation by the IAEA International Working Group on Training and Qualification of NPP Personnel (JWG-T and Q) and supported by a number of IAEA meetings on NPP personnel training. IAEA publications on NPP training are the only international documents available to all Member States with nuclear programmes. This report complements the following IAEA publications on NPP personnel training: Technical Reports Series No. 380, Nuclear Power Plant Personnel Training and its Evaluation, A Guidebook; IAEA-TECDOC-1057, Experience in the Use of Systematic Approach to Training (SAT) for Nuclear Power Plant Personnel and IAEA-TECDOC-1063, IAEA World Survey on Nuclear Power Plant Personnel Training. This TECDOC also supplements the IAEA Safety Guide 50-SG-O1 (Rev. 1), Staffing of Nuclear Power Plants and the Recruitment Training and Authorization of Operating Personnel and Safety Standards Series No. NS-R-2, Safety of Nuclear Power Plants. Operation. Within the context of this report NPP contractors are defined as any personnel working for a nuclear power plant who are not directly employed by the nuclear power plant. Competence is the ability to perform to identified standards; it comprises skills, knowledge and attitudes and may be developed through education, experience and training. Qualification is a formal statement of achievement, resulting from an auditable assessment; if competence is assessed, the qualification becomes a formal statement of competence and may be shown on a certificate, diploma, etc. It is recognized that personnel are used to perform tasks that are of a specialised or temporary nature where it is not feasible to hire or maintain a full-time NPP employee. Accordingly, contractors may be used in a variety of situations to support NPPs. Typical situations include: supplies and services being delivered by the contractors that are subject to different quality standards based on a graded approach to assuring
Beltrán López, Antonio
La Enfermedad Renal Crónica (ERC) se define como la disminución de la función renal, donde se reduce el filtrado glomerular (FG) estimado < 60 ml/min/1,73m2 o como la presencia de daño renal de forma persistente durante al menos tres meses. La enfermedad renal crónica (ERC) es una patología progresiva que afecta cada vez más a la población, el daño renal aumenta con el paso del tiempo, siendo su resultado el tratamiento renal sustitutivo, trasplante o incluso la muerte, el gran problema es qu...
Donly, Kevin J
This article discusses contemporary pediatric restorative dentistry. Indications and contraindications for the choice of different restorative materials in different clinical situations, including the risk assessment of the patient, are presented. The specific use of glass ionomer cement or resin-modified glass ionomer cement, resin-based composite, and stainless steel crowns is discussed so that preparation design and restoration placement is understood. Copyright © 2013 Elsevier Inc. All rights reserved.
Alptekin, Orkun; Alptekin, Nesrin
Selection of the most suitable contractor is an important process in public construction projects. This process is a major decision which may influence the progress and success of a construction project. Improper selection of contractors may lead to problems such as bad quality of work and delay in project duration. Especially in the construction projects of public buildings, the proper choice of contractor is beneficial to the public institution. Public procurement processes have different characteristics in respect to dissimilarities in political, social and economic features of every country. In Turkey, Turkish Public Procurement Law PPL 4734 is the main regulatory law for the procurement of the public buildings. According to the PPL 4734, public construction administrators have to contract with the lowest bidder who has the minimum requirements according to the criteria in prequalification process. Public administrators are not sufficient for selection of the proper contractor because of the restrictive provisions of the PPL 4734. The lowest bid method does not enable public construction administrators to select the most qualified contractor and they have realised the fact that the selection of a contractor based on lowest bid alone is inadequate and may lead to the failure of the project in terms of time delay Eand poor quality standards. In order to evaluate the overall efficiency of a project, it is necessary to identify selection criteria. This study aims to focus on identify importance of other criteria besides lowest bid criterion in contractor selection process of PPL 4734. In this study, a survey was conducted to staff of Department of Construction Works of Eskisehir Osmangazi University. According to TOPSIS (Technique for Order Preference by Similarity to the Ideal Solution) for analysis results, termination of construction work in previous tenders is the most important criterion of 12 determined criteria. The lowest bid criterion is ranked in rank 5.
Mazaheri, Yousef; Vargas, H Alberto; Nyman, Gregory; Shukla-Dave, Amita; Akin, Oguz; Hricak, Hedvig
To compare ADC values measured from diffusion-weighted MR (DW-MR) images of the prostate obtained with both endorectal and phased-array coils (ERC+PAC) to those from DW-MRI images obtained with an eight-channel torso phased-array coil (PAC) at 3.0 T. The institutional review board issued a waiver of informed consent for this HIPAA-compliant study. Twenty-five patients with biopsy-proven prostate cancer underwent standard 3-T MRI using 2 different coil arrangements (ERC+PAC and PAC only) in the same session. DW-MRI at five b-values (0, 600, 1000, 1200, and 1500 s/mm(2)) were acquired using both coil arrangements. On b=0 images, signal-to-noise ratios (SNRs) were measured as the ratio of the mean signal from PZ and TZ ROIs to the standard deviation from the mean signal in an artifact-free ROI in the rectum. Matching regions-of-interest (ROIs) were identified in the peripheral zone and transition zone on ERC-MRI and PAC-MRI. For each ROI, mean ADC values for all zero and non-zero b-value combinations were computed. Mean SNR with ERC-MRI at PZ (66.33 ± 27.07) and TZ (32.69 ± 12.52) was 9.27 and 5.52 times higher than with PAC-MRI ((7.32 ± 2.30) and (6.13 ± 1.56), respectively) (PERC-MRI (PERC. To address these requirements, clinical MR systems should have image processing capabilities which incorporate the noise distribution. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
This study describe the labeling of N-[3-(4-morpholino) propyl] -N-methyl-2 hydroxy-5-iodo-3-methylbenzylamine (ERC-9) with iodine-125 in liquid and ill melt states .The labeling in liquid state was controlled by many factors such as the ratio of radioiodine to the molar concentration of ERC-9, This test was carried out using iodine-131 instead of iodine-125 due to high activity required, and the maximum yield of 131 I ERC-9 was obtained at 90 - 277 MBq NaI 131 to 19.9 m M of ERC-9. The labeling reaction was preceded well at ph 3,5. Acetic acid was the most suitable solvent for the labeling reaction. One mg of cuprous chloride was catalyzed the reaction and reduced the reaction time from 45 min to 20 min. The molarity of sodium hydroxide played an important role in the labeling reaction, as the labeling yield was maximum at 0,01 M NaOH. The labeling in melt state using ammonium acetate as catalyst produced 92 % radiochemical yield. The labeling in melt state was fast, easy, and done in one-step. The biological studies reflected that the tracer was lipophilic, as high liver uptake (39.4 ± 2,1 %) was observed at 1 h post injection. The tracer was excreted to some extent via the kidneys. Activation energy required for the reaction completion in the presence of cuprous chloride was 31.4 KJ/ mol when the reaction was preceded at 80 degree C for 80 min
Krishna Rao, M. V.; Kumar, V. S. S.; Rathish Kumar, P.
A purely price-based approach to contractor selection has been identified as the root cause for many serious project delivery problems. Therefore, the capability of the contractor to execute the project should be evaluated using a multiple set of selection criteria including reputation, past performance, performance potential, financial soundness and other project specific criteria. An industry-wide questionnaire survey was conducted with the objective of identifying the important criteria for adoption in the selection process. In this work, a fuzzy set based model was developed for contractor prequalification/evaluation, by using effective criteria obtained from the percept of construction professionals, taking subjective judgments of decision makers also into consideration. A case study consisting of four alternatives (contractors in the present case) solicited from a public works department of Pondicherry in India, is used to illustrate the effectiveness of the proposed approach. The final selection of contractor is made based on the integrated score or Overall Evaluation Score of the decision alternative in prequalification as well as bid evaluation stages.
Full Text Available Hazardous waste is substance that threaten people and environment in case of improper storage, disposal and transport due to its concentration, physical and chemical properties. Companies producing hazardous waste as a result of several activities mostly do not have any own disposal facilities. In addition, they do not pay attention enough to determine the right contractor as a disposal facility. On the other hand, there are various qualitative and quantitative criteria affecting the selection of the contractor and conflicting with each other. The aim of the performed study is to assist one of these companies producing hazardous waste in the selection of the best contractor that eliminates hazardous waste economic and harmless way. In the study, contractor weights in percentage is calculated by using Analytic Network Process (ANP as one of the multi-criteria decision making (MCDM methods and widely used in the literature which considers both qualitative and quantitative criteria. In the next step, by the help of the mathematical model, contractors that will be given which type of hazardous waste are identified. This integrated approach can be used as a guide for similar firms.
Eric J. Gustafson
Ecological restoration has increased in prominence in recent years as environmental policies have slowed the rate of environmental degradation in many parts of the world and practitioners have looked for active ways to reverse the damage. Because of the vast number of types and contexts of degraded ecological systems, the field of ecological restoration is still very...
Halme, Panu; Allen, Katherine A.; Aunins, Ainars
we introduce northern forests as an ecosystem, discuss the historical and recent human impact and provide a brief status report on the ecological restoration projects and research already conducted there. Based on this discussion, we argue that before any restoration actions commence, the ecology......The alarming rate of ecosystem degradation has raised the need for ecological restoration throughout different biomes and continents. North European forests may appear as one of the least vulnerable ecosystems from a global perspective, since forest cover is not rapidly decreasing and many...... on Biological Diversity. Several northern countries are now taking up this challenge by restoring forest biodiversity with increasing intensity. The ecology and biodiversity of boreal forests are relatively well understood making them a good model for restoration activities in many other forest ecosystems. Here...
Wenzel, Michael; Okimoto, Tyler G; Feather, Norman T; Platow, Michael J
The emergence of restorative justice as an alternative model to Western, court-based criminal justice may have important implications for the psychology of justice. It is proposed that two different notions of justice affect responses to rule-breaking: restorative and retributive justice. Retributive justice essentially refers to the repair of justice through unilateral imposition of punishment, whereas restorative justice means the repair of justice through reaffirming a shared value-consensus in a bilateral process. Among the symbolic implications of transgressions, concerns about status and power are primarily related to retributive justice and concerns about shared values are primarily related to restorative justice. At the core of these processes, however, lies the parties' construal of their identity relation, specifically whether or not respondents perceive to share an identity with the offender. The specific case of intergroup transgressions is discussed, as are implications for future research on restoring a sense of justice after rule-breaking.
Full Text Available Reduced demand for services, lack of finances for projects and idle resources at homehave resulted in loss of business for Malaysian construction contractors. Among the optionsthat are explored in this paper is internationalisation of services to help the contractorsgainfully employ their resources and diversify their markets. Integration of worldmarkets, faster transportation and improved means of communication have made it possiblefor contractors to undertake work in international markets. It was found that contractorswere motivated to internationalise by need to make the firm a viable one byconsidering the long-term profitability. Reputation and size of the firm were found to befactors that help contractors in winning contracts overseas. Most non-exporters were concernedwith provision of market intelligence and export credit finance. It was found thatproviding relevant market information, accessible to both exporter and non-exporters, canhelp firms make informed decisions. Any assistance provided should match the firm to thestage the firm has reached in exporting
Ontario Hydro's Fossil Business has developed and implemented a practical program to ensure that the due diligence requirements for contractors are met, particularly in the health and safety area. Companies in the power generation business are hiring contractors to protect their competitive potential by having them perform specialty work outside the core business of generating electricity. The reasons behind this trend, and the need for companies to develop comprehensive contractor safety management systems to avoid legislative liability and cost overruns, and to have contractors work safely, are examined. The main elements of Ontario Hydro's Fossil Business Contractor Safety Management Program (contractor safety policy, contractor safety manual, contractor safety training, and a contractor safety performance database) are discussed. 2 figs., 2 appendices
Swed, Ori; Crosbie, Thomas Alexander
Though private military and security companies (PMSCs) have been addressed extensively in the literature, little research has been done on the contractors themselves, leaving us in the dark as to who these individuals are. In this article, we focus on the critical case of the United States armed...... and concomitant evolution of the security sector, while noting a new trend that points to the need for moving from the macrosocial to the microsocial level of inquiry. Second, we indicate the challenges contractors pose to the sociological paradigm of military professionalism: These suggest a need to move from...
Koch, Christian; Simonsen, Rolf
Traditional strategic management and operations strategy wants us to believe that the implementation of management concepts is a simple strategic choice made by top managers. In this paper we introduce the story of Lean Construction entering into the organisation of a Danish contractor. Lean...... concepts. The paper presents findings from empirical work in collaboration with a large Danish contractor. The case is analysed from the perspective of operation strategy and political process. It is observed how the management concept is socially constructed and negotiated through political action of key...
Gidon, Alexandre; Bardin, Sabine; Cinquin, Bertrand; Boulanger, Jerome; Waharte, François; Heliot, Laurent; de la Salle, Henri; Hanau, Daniel; Kervrann, Charles; Goud, Bruno; Salamero, Jean
A large body of knowledge relating to the constitution of Rab GTPase/Rab effector complexes and their impact on both membrane domain organization and overall membrane trafficking has been built up in recent years. However in the context of the live cell there are still many questions that remain to be answered, such as where and when these complexes assemble and where they perform their primary function(s). We describe here the dynamic processes that take place in the final steps of the Rab11A dependent recycling pathway, in the context of the membrane platform constituted by Myosin Vb, Rab11A, and Rab11-FIP2. We first confirm that a series of previously reported observations obtained during the study of a number of trafficking cargoes also apply to langerin. Langerin is a cargo molecule that traffics through Rab11A-positive membrane domains of the endosomal recycling pathway. In order to explore the relative dynamics of this set of partners, we make extensive use of a combinatory approach of Live-FRET, fast FRAP video, fast confocal and TIRF microscopy modalities. Our data show that the Myosin Vb/Rab11A/Rab11-FIP2 platform is spatially involved in the regulation of langerin trafficking at two distinct sites within live cells, first at the sorting site in the endosomal recycling compartment (ERC) where transport vesicles are formed, and subsequently, in a strict time-defined order, at the very late stage of docking/tethering and fusion of these langerin recycling vesicles to the plasma membrane. © 2012 John Wiley & Sons A/S.
Albert, J G; Finkelmeier, F; Friedrich-Rust, M; Kronenberger, B; Trojan, J; Zeuzem, S; Sarrazin, C
The variety of rendezvous (RV) procedures has recently been extended by EUS- and PTCD-guided procedures as a complementary means to conventional ERCP. We have identified indication criteria and the potential of biliary PTCD-guided vs. EUS-guided RV. Consecutive patients with bile duct obstruction who underwent RV were included. In all, ERCP alone was unable to achieve treatment success. Indication, technical success, and outcome in PTCD- vs. EUS-guided RV were retrospectively compared to identify criteria that indicate preference of RV technique. Site of obstruction, clinical scenario (stenosis with abscess vs. no abscess) and reason for previous failure of ERC were evaluated. In 32 patients, three different indications for RV procedures were identified: First, a one-step access to assist in failed ERCP (type 1, intra-ductal RV); second, temporary drainage for prolonged treatment of complex biliary disease (type 2, intra-ductal RV), and drainage of cholangio-abscess with re-establishing bile outflow (type 3, intra-abscess RV). Indication of PTCD- vs. EUS-guided rendezvous was competitive in type 1, but exclusive in favor of PTCD in types 2 and 3. The site of biliary obstruction indicated the anatomic location of RV procedures. This classification may help to define inclusion criteria for prospective studies on biliary RV procedures. Choice of therapeutic strategy depends on the anatomic location of the biliary obstruction and the type of the biliary lesion. PTCD-guided RV might improve outcome in cholangio-abscess. © Georg Thieme Verlag KG Stuttgart · New York.
Hanau, H.; Parker, R. J.; Zaretsky, E. V.; Chen, S. M.; Bull, H. L.
A joint program was undertaken by the NASA Lewis Research Center and the Army Aviation Systems Command to restore by grinding those rolling-element bearings which are currently being discarded at aircraft engine and transmission overhaul. Three bearing types were selected from the UH-1 helicopter engine (T-53) and transmission for the pilot program. No bearing failures occurred related to the restoration by grinding process. The risk and cost of a bearing restoration by grinding programs was analyzed. A microeconomic impact analysis was performed.
Jones, A K; Chamley, M E
Many excavated quarries are subsequently used for waste disposal operations and frequently imported landfill provides the only means of restoring a former quarry to some beneficial afteruse. Concentrating solely on the final surface cover, this paper sets out some of the principles, which should be considered by those involved in landfill operations to ensure the long term success of restoration schemes. With the emphasis on restoration to agriculture, factors such as availability of cover materials and depths necessary are discussed in terms of requirements to support plant growth, protect clay capping layers and prevent damage to agricultural implements. Soil handling and appropriate after care management are considered. 4 refs.
Denham, D. H.
This narrative and accompanying diagrams provide a simplified summary of the RadCon Occurrence Reporting criteria to allow Environmental Restoration Contractor (ERC) staff to efficiently recognize occurrences and to effectively initiate the implementation of the requirements of U.S. Department of Energy (DOE) Order 232.1A, Occurrence Reporting and Processing of Operations Information, and of the ERC criteria defined in BHI-MA-02, ERC Project Procedures, Procedure 2.6, ''Occurrence Investigation and Reporting.'' These directives promote timely identification, categorization, notification, and reporting to DOE and ERC management of reportable occurrences at DOE-owned or -operated facilities that could (1) affect health and safety of the public, (2) seriously impact the intended purpose of DOE facilities, (3) adversely affect the credibility of DOE, or (4) have a noticeable adverse effect on the environment
Not only is this legislation completely unique, but it appears wholly at odds with international opinion. In this article we place private security contractors (PSCs) under the microscope of international law, exploring the role they play in armed conflicts, and the status afforded them by international humanitarian law (IHL).
This volume contains the proceedings for the DOE Human Genome Program`s Contractor-Grantee Workshop V held in Sante Fe, New Mexico January 28, February 1, 1996. Presentations were divided into sessions entitled Sequencing; Mapping; Informatics; Ethical, Legal, and Social Issues; and Infrastructure. Reports of individual projects described herein are separately indexed and abstracted for the database.
This report is one of series of annual reports provided by the US Department of Energy (DOE) summarizing occupational radiation exposures received by DOE and DOE contractor employees. These reports provide an overview of radiation exposures received each year, as well as identification of trends in exposures being experienced over the years. 5 figs., 30 tabs
The Configuration Management Plan for the Tank Farm Contractor describes configuration management the contractor uses to manage and integrate its technical baseline with the programmatic and functional operations to perform work. The Configuration Management Plan for the Tank Farm Contractor supports the management of the project baseline by providing the mechanisms to identify, document, and control the technical characteristics of the products, processes, and structures, systems, and components (SSC). This plan is one of the tools used to identify and provide controls for the technical baseline of the Tank Farm Contractor (TFC). The configuration management plan is listed in the management process documents for TFC as depicted in Attachment 1, TFC Document Structure. The configuration management plan is an integrated approach for control of technical, schedule, cost, and administrative processes necessary to manage the mission of the TFC. Configuration management encompasses the five functional elements of: (1) configuration management administration, (2) configuration identification, (3) configuration status accounting, (4) change control, and (5 ) configuration management assessments.
Full Text Available Construction projects do not require a large capital outlay but a large working capital to start up the project. Unfortunately, for small contractors there are very limited options available from the banks or other lending institutions to cover this large working capital requirement in the absence of sufficient collateral. The “Project Finance” method presented in this paper is recommended as the most effective method for small contractors in the United States. The problems of small and start up contractors in funding their projects have been little addressed in the literature. The current financing practices were observed through both the literature review and interviews with contractors and bankers in the western Michigan area and subsequently a system has been proposed which could help a small start-up company seeking higher growth. The growth rates that can be achieved using the project finance system in contrast to the traditional “line of credit” arrangements as illustrated in this paper show that the project finance model is beneficial.
... information technology. 939.7002 Section 939.7002 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Implementing DOE Policies and Procedures 939.7002 Contractor acquisition of information technology. (a) Management and operating (M&O...
The Configuration Management Plan for the Tank Farm Contractor describes configuration management the contractor uses to manage and integrate its technical baseline with the programmatic and functional operations to perform work. The Configuration Management Plan for the Tank Farm Contractor supports the management of the project baseline by providing the mechanisms to identify, document, and control the technical characteristics of the products, processes, and structures, systems, and components (SSC). This plan is one of the tools used to identify and provide controls for the technical baseline of the Tank Farm Contractor (TFC). The configuration management plan is listed in the management process documents for TFC as depicted in Attachment 1, TFC Document Structure. The configuration management plan is an integrated approach for control of technical, schedule, cost, and administrative processes necessary to manage the mission of the TFC. Configuration management encompasses the five functional elements of: (1) configuration management administration, (2) configuration identification, (3) configuration status accounting, (4) change control, and (5 ) configuration management assessments
... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Medicare & Medicaid Services 42 CFR Part 455 [CMS-6034-P] RIN 0938-AQ19 Medicaid Program; Recovery Audit Contractors AGENCY: Centers for Medicare & Medicaid Services (CMS), HHS. ACTION: Proposed rule. SUMMARY: This proposed rule would provide guidance to...
For the implementation of low carbon construction in our construction industry, the contractors need to be ready and have knowledge to adopt low carbon construction ... A checklist was established by summarizing the highest low carbon activities from each category which were sustainable site planning and management, ...
....g., late or nonpayment to subcontractors, trafficking violations, tax delinquency, failure to report... applicable) (e.g.; late or nonpayment to subcontractors, trafficking violations, tax delinquency, failure to... that allowing contractors to ``report to the CPARS system'' would have a negative impact on future...
This article offers a method for selecting contractors in an objective, transparent and participative way. The use of the Decision Analysis System (DAS), also referred to as decision-making by objectives, makes it possible that a large number of objectives can be taken into account to select the best amongst a wide range of ...
Malone, R.D. [ed.
The Fuels Technology Contractors Review Meeting was held November 16-18, 1993, at the Morgantown Energy Technology Center (METC) in Morgantown, West Virginia. This meeting was sponsored and hosted by METC, the Office of Fossil Energy, U.S. Department of Energy (DOE). METC periodically provides an opportunity to bring together all of the R&D participants in a DOE-sponsored contractors review meeting to present key results of their research and to provide technology transfer to the active research community and to the interested public. This meeting was previously called the Natural Gas Technology Contractors Review Meeting. This year it was expanded to include DOE-sponsored research on oil shale and tar sands and so was retitled the Fuels Technology Contractors Review Meeting. Current research activities include efforts in both natural gas and liquid fuels. The natural gas portion of the meeting included discussions of results summarizing work being conducted in fracture systems, both natural and induced; drilling, completion, and stimulation research; resource characterization; delivery and storage; gas to liquids research; and environmental issues. The meeting also included project and technology summaries on research in oil shale, tar sands, and mild coal gasification, and summaries of work in natural-gas fuel cells and natural-gas turbines. The format included oral and poster session presentations. Individual papers have been processed separately for inclusion in the Energy Science and Technology database.
... include a recommendation by the SDC as to a proposed course of action; (2) The debarment decision-making... proposed debarment; (3) The suspension decision-making process, which shall afford the contractor (and any... Management, Contracting; Attention: Contracting Policy, 1900 E Street NW., Washington, DC 20415; or email...
This document is a revision of the document titled above, summarizing the technical baseline of the Tank Farm Contractor. It is one of several documents prepared by CH2M HILL Hanford Group, Inc. to support the U.S. Department of Energy Office of River Protection Tank Waste Retrieval and Disposal Mission at Hanford
Buser, Martine; Koch, Christian; Tambo, Torben
for construction are developing as well. A recent review shows a small portfolio of systems using mobile computing to support specifically the construction project processes. The aim of this paper is to evaluate the use of mobile computing at small construction contractors. The paper presents a quantitative...
Nurisra; Malahayati, Nurul; Mahmuddin
Contractor companies must have the competitive advantage to compete in maintaining the survival of the company. Problems arise because quite a lot of advantages can be used and these advantages must be used appropriately to produce competitiveness for the company to continue to compete and to win the competition. This study aims to determine the main factors affecting the competitiveness of medium-class contractors in Banda Aceh. Data collection was obtained through questionnaires distributed to 31 middle-class contractors in Banda Aceh. Data processing and analysis is done by using descriptive analysis. Based on the result of descriptive analysis, it can be concluded that the most important competitiveness factor with a mean score value 4.52 is the relationship, and the factor that has the highest mean score value is the relationship with the government of 4.97, while the result of the ranking analysis is obtained 25 factor that is critical to the competitiveness of medium-class contractors in Banda Aceh.
... disadvantaged businesses, women-owned small businesses, HBCUs, other minority institutions of higher learning... contractor participation. 919.7006 Section 919.7006 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Department of Energy Mentor-Protege Program 919...
... Part II The President Memorandum of January 20, 2010--Addressing Tax Delinquency by Government... of January 20, 2010 Addressing Tax Delinquency by Government Contractors Memorandum for the Heads of... contracts are awarded to tens of thousands of companies with serious tax delinquencies. The total amount in...
Smith, M.H.; Eschbach, P.A.; Harty, R.; Millet, W.H.; Scholes, V.A.
All US Department of Energy (DOE) and DOE contractors, are required to submit occupational radiation exposure records to a central depository. In 1989, data were required to be submitted for all employees who were required to be monitored in accordance with DOE Order 5480.11 and for all visitors who had a positive exposure. The data required included the external penetrating whole-body dose equivalent, the shallow dose equivalent, and a summary of internal depositions of radioactive material above specified limits. Data regarding the exposed individuals included the individual's age, sex, and occupational category. This report is a summary of the external penetrating whole-body dose equivalents and shallow dose equivalents reported by DOE and DOE contractors for the calendar year 1989. A total of 90,882 DOE and DOE contractor employees were reported to have been monitored for whole-body ionizing radiation exposure during 1989. This represents 53.6% of all DOE and DOE contractor employees and is an increase (4.3 %) from the number of monitored employees for 1988. In addition to the employees, 12,643 visitors were monitored
Mayoux, J.C.; Derche, B.
The first purpose of this paper is to show how the French common law -as it results from the code of labour and holdings of the courts- deals with the intervention of contractors. The second part analyses the special regulations in force to ensure radiation protection [fr
3 Contractor Country Contract Number Bundesamt Fuer Wehrtechnik FRG DAJA3786C0326 Bundesamt Fuer Wehrtechnik FRG F6154686D0022 Construcciones ...Aeronauticas SA Spain F0960385C0006 Construcciones Aeronauticas SA Spain F4260086C6464 Daimler Benz AG FRG DAJA3778GOO11 Eaton Corp. FRG F0960382D0663
... repositories. 227.7207 Section 227.7207 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Computer Software and Computer Software Documentation 227.7207 Contractor data repositories. Follow 227.7108 when it is in the Government's interests to have a data repository include computer software or to...
This bibliography was compiled to provide biologists, engineers, and planners at Corps Districts and other agencies/ institutions with a guide to the diverse body of literature on coastal wetland restoration...
Oswald J Schmitz
Full Text Available It is widely held that humankind's destructive tendencies when exploiting natural resources leads to irreparable harm to the environment. Yet, this thinking runs counter to evidence that many ecological systems damaged by severe natural environmental disturbances (e.g., hurricanes can restore themselves via processes of natural recovery. The emerging field of restoration ecology is capitalizing on the natural restorative tendencies of ecological systems to build a science of repairing the harm inflicted by humans on natural environment. Evidence for this, for example, comes from a new meta-analysis of 124 studies that synthesizes recovery of impacted wetlands worldwide. While it may take up to two human generations to see full recovery, there is promise, given human will, to restore many damaged wetlands worldwide.
the return of a degraded ecosystem to a close approximation of its remaining natural potential - is experiencing a groundswell of support across the United States. The number of stream, river, lake, wetland and estuary restoration projects grows yearly
Clemmensen, Thomas Juel
In 2003 the Skjern River Restoration Project in Denmark was awarded the prestigious Europa Nostra Prize for ‘conserving the European cultural heritage’ (Danish Nature Agency 2005). In this case, however, it seems that the conservation of one cultural heritage came at the expense of another cultural...... this massive reconstruction work, which involved moving more than 2,7 million cubic meters of earth, cause a lot of ‘dissonance’ among the local population, the resulting ‘nature’ and its dynamic processes are also constantly compromising the preferred image of the restored landscape (Clemmensen 2014......). The presentation offers insight into an on-going research and development project - Skjern River Restoration Counterfactual, which question existing trends and logics within nature restoration. The project explores how the Skjern River Delta could have been ‘restored’ with a greater sensibility for its cultural...
operation due to presence of increased use of nonlinear loads (computers, microcontrollers ... simulations of a dynamic voltage restorer (DVR) was achieved using MATLAB/Simulink. ..... using Discrete PWM generator, then the IGBT inverter.
... over the $92 billion of Government property in the custody of contractors. After several years of planning, DoD has not developed a standard accounting system for recording, tracking, and reporting Government property in the custody of contractors...
The use of contractors in the theater of operations is nothing new. However downsizing efforts and outsourcing as well as the increasing complexity of military equipment has increased military reliance on contractors...
Arnold, Scot A; Harmon, Bruce R; Tyson, Karen W; Fasana, Kenton G; Wait, Christopher S
.... The goal of profit policy is a contract price that reimburses the contractor for its costs, provides the necessary incentives to yield beneficial performance, and to provide the contractor with sufficient risk reward...
Arnold, Scot A; Harmon, Bruce R; Tyson, Karen W; Fasana, Kenton G; Wait, Christopher S
.... The goal of profit policy is a contract price that reimburses the contractor for its costs, provides the necessary incentives to yield beneficial performance, and provides the contractor with sufficient risk reward...
Report #17-P-0409, September 27, 2017. Not vetting contractor personnel before granting them network access exposes the EPA to risks. Contractor personnel with potentially questionable backgrounds who access sensitive agency data could cause harm.
... the Contractor's negligence, indemnification shall be at a rate not to exceed sixty cents per pound per article. (ii) Negligent damage. When loss or damage is caused by the negligence of the Contractor...
Lyle Solverson; David C. Baumgartner
Describes and analyzes the activities of farm building contractors and manufacturers in Illinois, Indiana, Iowa, and Missouri. Contractors and manufacturers are setting the trend in the farm building market in terms of building type and size and materials used.
Tagler, Richard C.
The efforts of a government organization and its major contractors to foster a continuous improvement environment which transcends the traditional government/contractor relationship is discussed. This relationship is aimed at communication, partnership, and trust - creating benefits for all involved.
...; Preventing Personal Conflicts of Interest for Contractor Employees Performing Acquisition Functions AGENCY... approve a new information collection requirement regarding Preventing Personal Conflicts of Interest for... Conflicts of Interest for Contractor Employees Performing Acquisition Functions by any of the following...
This thesis focuses on situations where the obligation is on the contractor, and examines the existing FAR provisions and clauses to explore whether they are adequate to ensure government contractor...
Pathe-Neuschäfer-Rube, Andrea; Neuschäfer-Rube, Frank; Püschel, Gerhard P
The human FP-R (F2alpha prostaglandin receptor) is a Gq-coupled heptahelical ectoreceptor, which is of significant medical interest, since it is a potential target for the treatment of glaucoma and preterm labour. On agonist exposure, it mediates an increase in intracellular inositol phosphate formation. Little is known about the structures that govern the agonist-dependent receptor activation. In other prostanoid receptors, the C-terminal domain has been inferred in the control of agonist-dependent receptor activation. A DRY motif at the beginning of the second intracellular loop is highly conserved throughout the G-protein-coupled receptor family and appears to be crucial for controlling agonist-dependent receptor activation. It is replaced by an ERC motif in the FP-R and no evidence for the relevance of this motif in ligand-dependent activation of prostanoid receptors has been provided so far. The aim of the present study was to elucidate the potential role of the C-terminal domain and the ERC motif in agonist-controlled intracellular signalling in FP-R mutants generated by site-directed mutagenesis. It was found that substitution of the acidic Glu(132) in the ERC motif by a threonine residue led to full constitutive activation, whereas truncation of the receptor's C-terminal domain led to partial constitutive activation of all three intracellular signal pathways that had previously been shown to be activated by the FP-R, i.e. inositol trisphosphate formation, focal adhesion kinase activation and T-cell factor signalling. Inositol trisphosphate formation and focal adhesion kinase phosphorylation were further enhanced by ligand binding in cells expressing the truncation mutant but not the E132T (Glu132-->Thr) mutant. Thus C-terminal truncation appeared to result in a receptor with partial constitutive activation, whereas substitution of Glu132 by threonine apparently resulted in a receptor with full constitutive activity.
Fallu, Angelo; Dabouz, Farida; Furtado, Melissa; Anand, Leena; Katzman, Martin A
Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral disorder with onset during childhood. Multiple aspects of a child's development are hindered, in both home and school settings, with negative impacts on social, emotional, and cognitive functioning. If left untreated, ADHD is commonly associated with poor academic achievement and low occupational status, as well as increased risk of substance abuse and delinquency. The objective of this study was to evaluate adult ADHD subject reported outcomes when switched from a stable dose of CONCERTA(®) to the same dose of generic Novo-methylphenidate ER-C(®). Randomized, double-blind, cross-over, phase IV trial consisted of two phases in which participants with a primary diagnosis of ADHD were randomized in a 1:1 ratio to 3 weeks of treatment with CONCERTA or generic Novo-Methylphenidate ER-C. Following 3 weeks of treatment, participants were crossed-over to receive the other treatment for an additional 3 weeks. Primary efficacy was assessed through the use of the Treatment Satisfaction Questionnaire for Medication, Version II (TSQM-II). Participants with ADHD treated with CONCERTA were more satisfied in terms of efficacy and side effects compared to those receiving an equivalent dose of generic Novo-Methylphenidate ER-C. All participants chose to continue with CONCERTA treatment at the conclusion of the study. Although CONCERTA and generic Novo-Methylphenidate ER-C have been deemed bioequivalent, however the present findings demonstrate clinically and statistically significant differences between generic and branded CONCERTA. Further investigation of these differences is warranted.
... Products Requiring Federal Contractor Certification as to Forced or Indentured Child Labor Pursuant to... ``Procedural Guidelines for the Maintenance of the List of Products Requiring Federal Contractor Certification... List of Products Requiring Federal Contractor Certification as to Forced or Indentured Child Labor...
... List of Products Requiring Federal Contractor Certification as to Forced or Indentured Child Labor... Contractor Certification as to Forced or Indentured Child Labor.'' This notice adds a product, hand-woven... of the List of Products Requiring Federal Contractor Certification as to Forced or Indentured Child...
... 42 Public Health 2 2010-10-01 2010-10-01 false When CMS or its contractors may participate in an... Hearings § 405.1010 When CMS or its contractors may participate in an ALJ hearing. (a) An ALJ may request, but may not require, CMS and/or one or more of its contractors to participate in any proceedings...
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Performance of work by the....236-72 Performance of work by the contractor. As prescribed in 836.501, insert the following clause: Performance of Work by the Contractor (JUL 2002) The clause entitled “Performance of Work by the Contractor...
... Architect-Engineer Contractor. 52.236-23 Section 52.236-23 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.236-23 Responsibility of the Architect-Engineer Contractor. As prescribed in 36.609-2(b), insert the following clause: Responsibility of the Architect-Engineer Contractor (APR 1984) (a...
... 32 National Defense 6 2010-07-01 2010-07-01 false Systems of records operated by a contractor... ADMINISTRATION PRIVACY ACT PROGRAM Overview of the Privacy Act Program § 806b.6 Systems of records operated by a contractor. Contractors who are required to operate or maintain a Privacy Act system of records by contract...
... Federal Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS Case 2009-D025... conducting a Contractor Insurance/Pension Review from Procedures, Guidance, and Information (PGI) to the... This final rule relocates requirements for Contractor Insurance/ Pension Review to DFARS 242.7302 from...
... ADMINISTRATION [OMB Control No. 9000-0032] Federal Acquisition Regulation; Submission for OMB Review; Contractor... previously approved information collection requirement concerning contractor use of interagency motor pool... contracting officer may authorize cost-reimbursement contractors to obtain, for official purposes only...
... 9000-AM13 Federal Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor... contractor in order to reimburse the tax imposed (26 U.S.C. 5000C Note). On February 22, 2012, DoD, GSA, and... with the statute, FAR 31.205-41 is amended to inform the Government and contractors that the costs of...
... Acquisition Regulation; FAR Case 2009-027, Personal Identity Verification of Contractor Personnel AGENCIES... of collecting from contractors all forms of Government provided identification once they are no..., titled Controls Over the Contractor Common Access Card (CAC) Life Cycle, was performed to determine...
... of Language Services Contractor Application Form ACTION: Notice of request for public comment... Collection: Office of Language Services Contractor Application Form. OMB Control Number: 1405-0191. Type of... become contractors for the U.S. Department of State, Office of Language Services, the information...
... Information Collection: Comment Request; Multifamily Contractor's Mortgagor's Cost Breakdowns and... comments on the subject proposal. Contractors use the form HUD-2328 to establish a schedule of values of construction items on which the monthly advances or mortgage proceeds are based. Contractors use the form HUD...
... ENVIRONMENTAL PROTECTION AGENCY [FRL-9200-8] Clean Water Act; Contractor Access to Confidential... Recovery Act (RCRA). Transfer of the information will allow the contractor and subcontractors to access... contractors and subcontractors over the history of the effluent guidelines program. EPA determined that this...
... Contractor Employees Performing Acquisition Functions AGENCIES: Department of Defense (DoD), General Services... personal conflicts of interest by employees of Government contractors as required by statute. DATES... clause for future orders. In the event that a contractor refuses to accept such a modification, the...
... 9000-AL60 Federal Acquisition Regulation; Personal Identity Verification of Contractor Personnel AGENCY... requirement of collecting from contractors all forms of Government-provided identification once they are no...D Inspector General Audit Report No. D-2009-005, entitled ``Controls Over the Contractor Common...
... of Universal Identifier and Central Contractor Registration AGENCY: Office of Federal Financial...) numbers and maintain current registrations in the Central Contractor Registration (CCR) database. An... CONTRACTOR REGISTRATION Sec. Subpart A--General 25.100 Purposes of this part. 25.105 Types of awards to which...
... Contractor Personnel AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION... (FY) 2009 and expand coverage on contractor requirements and responsibilities relating to alleged crimes by or against contractor personnel. DATES: Effective February 28, 2013. FOR FURTHER INFORMATION...
... Federal Acquisition Regulation Supplement: Alleged Crimes By or Against Contractor Personnel (DFARS Case... (DFARS) to expand coverage on contractor requirements and responsibilities relating to alleged crimes by or against contractor personnel. DATES: Comment Date: Comments on the proposed rule should be...
... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 2 [FRL-9733-8] Clean Water Act; Contractor Access to... transfer of confidential business information to contractor, subcontractors, and consultants. SUMMARY: The... certain industries. We have determined that the contractors listed below require access [[Page 60963
... Services Contractor Records SUMMARY: Notice is hereby given that the Department of State proposes to create a new system of records, Personal Services Contractor Records, State-76, pursuant to the provisions... July 20, 2011. It is proposed that the new system be named ``Personal Services Contractor Records.'' It...
... 9000-AM56 Federal Acquisition Regulation; Pilot Program for Enhancement of Contractor Employee... program enhancing whistleblower protections for contractor employees. DATES: Effective: September 30, 2013... contractor employees at FAR subpart 3.9. The pilot program is mandated by section 828, entitled ``Pilot...
... of Language Services Contractor Application Form ACTION: Notice of request for public comment and...: Title of Information Collection: Office of Language Services Contractor Application Form. OMB Control... States. If candidates successfully become contractors for the U.S. Department of State, Office of...
...-AH97 Defense Federal Acquisition Regulation Supplement: Enhancement of Contractor Employee... contractor and subcontractor employees. DATES: Effective date: September 30, 2013. In accordance with FAR 1... Whistleblower Protections for Contractor Employees) made extensive changes to 10 U.S.C. 2409, entitled...
... Federal Acquisition Regulation; Basic Safeguarding of Contractor Information Systems AGENCY: Department of... Acquisition Regulation (FAR) to add a new subpart and contract clause for the basic safeguarding of contractor... information) that will be resident on or transiting through contractor information systems. DATES: Interested...
... ENVIRONMENTAL PROTECTION AGENCY [FRL-9208-9] Clean Water Act; Contractor Access to Confidential... electric industry to a new subcontractor of a contractor, Eastern Research Group (ERG). EPA previously... contractors and subcontractors to access information necessary to support EPA in the planning, development...
... Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor Excise Tax AGENCIES.... Additionally, the law stipulates that no funds are to be disbursed to any foreign contractor in order to... payment. Additionally, the law stipulates that no funds are to be disbursed to any foreign contractor in...
... Activities; Proposed Collection; Comment Request; Contractor Conflicts of Interest AGENCY: Environmental....regulations.gov . Title: Contractor Conflicts of Interest. ICR numbers: EPA ICR No. 1550.09, OMB Control No... control numbers in certain EPA regulations is consolidated in 40 CFR part 9. Abstract: EPA contractors...
...; Contractor Conflicts of Interest AGENCY: Environmental Protection Agency. ACTION: Notice. SUMMARY: In... control numbers in certain EPA regulations is consolidated in 40 CFR part 9. Abstract: EPA contractors... cleanup and enforcement and because its contractors are often involved in both activities, it is...
... ENVIRONMENTAL PROTECTION AGENCY [FRL-9904-94-OW] Clean Water Act; Contractor Access to... Transfer of Confidential Business Information to Contractor, Subcontractors, and Consultants. SUMMARY: The... contractors listed below require access to CBI submitted to EPA under Section 308 of the Clean Water Act (CWA...
... Activities; Proposed Collection; Comment Request; Contractor Cumulative Claim and Reconciliation (Renewal... identify the Docket ID Number EPA-HQ-OARM-2011-0997, Contractor Cumulative Claim and Reconciliation. Hand... information collection activity or ICR does this apply to? Affected entities: All contractors who have...
This document provides the technical framework for groundwater restoration under Phase II of the Uranium Mill Tailings Remedial Action (UMTRA) Project. A preliminary management plan for Phase II has been set forth in a companion document titled ''Preplanning Guidance Document for Groundwater Restoration''. General principles of site characterization for groundwater restoration, restoration methods, and treatment are discussed in this document to provide an overview of standard technical approaches to groundwater restoration
Mileto, C.; Vegas, F.
In addition to the technological evolution over the last two centuries, survey has experienced two main conceptual leaps: the introduction of photography as a tool for an indiscriminate register for reality, and the shift from autographic to allographic survey, phenomena which can generate a distancing effect within the restoration process. Besides, this text presents the relationship between survey in its numerous forms and technologies (manual and semi-manual to more complex ones like scanner-laser) and the restoration of the building, either for establishing a diagnosis, operating or valorizating, illustrating it with examples developed by the authors, as well as the criteria to be applied when documenting a building to be restored, irrespective of the means and technology available in each case.
Full Text Available In addition to the technological evolution over the last two centuries, survey has experienced two main conceptual leaps: the introduction of photography as a tool for an indiscriminate register for reality, and the shift from autographic to allographic survey, phenomena which can generate a distancing effect within the restoration process. Besides, this text presents the relationship between survey in its numerous forms and technologies (manual and semi-manual to more complex ones like scanner-laser and the restoration of the building, either for establishing a diagnosis, operating or valorizating, illustrating it with examples developed by the authors, as well as the criteria to be applied when documenting a building to be restored, irrespective of the means and technology available in each case.
Westinghouse Hanford Company developed a generic Radiation Worker safety CBT course for Department of Energy contractors. Task analysis concentrated on actual and potential tasks and included visits to fourteen different contractor sites. Team Design and Prototype verification formed the major portion of the development phase. Lesson entry was accomplished using the WISE author system from WICAT Systems, Inc. The course features graded task simulations for both Pretest and Final; fourteen Topics in five Lessons, each Topic keyed to ''Critical Acts'' and Questions in the Pretest and Final; Automatic, Intensive, and Manual modes of instruction available for each Lesson; Practical Problems and Sample Questions associated with each Topic; and provisions for local configuration in several areas. The course is deliverable on IBM PC compatible equipment. 2 refs
Fitzsimmons, Tim [Dept. of Energy (DOE), Washington, DC (United States). Office of Basic Energy Sciences. Division of Materials Sciences and Engineering; Kini, Arvind [Dept. of Energy (DOE), Washington, DC (United States). Office of Basic Energy Sciences. Division of Materials Sciences and Engineering; Kelley, Dick [Dept. of Energy (DOE), Washington, DC (United States). Office of Basic Energy Sciences. Division of Materials Sciences and Engineering
This volume highlights the scientific content of the 2006 Fundamental Research Underlying Solid-State Lighting Contractors Meeting sponsored by the Division of Materials Sciences and Engineering (DMS&E) in the Office of Basic Energy Sciences (BES) of the U. S. Department of Energy (DOE). This meeting is the second in a series of research theme-based Contractors Meetings and will focus on BES/DMS&E-funded research that underpins solid-state lighting technology. The meeting will feature research that cuts across several DMS&E core research program areas. The major programmatic emphasis is on developing a fundamental scientific base, in terms of new concepts and new materials that could be used or mimicked in designing novel materials, processes or devices.
Robins, K.B.; Roberts, J.D.M.
The contract strategies developed by the two major E and P companies operating in the North Sea emphasize teamwork between operator and contractors to achieve the common goal of maximizing project value. These strategies have had significant repercussions across the whole industry. This paper compares these strategies and concludes that although they are structurally different, they have the same fundamental objectives. It describes the evolution of what these operators consider to be their core business, with the resultant changing roles for both operator and contractor staff. Several examples of results achieved through implementing these changes are described, highlighting the need for a structured performance measurement system to quantify the success of these initiatives. Finally, the potential for even greater efficiency improvements through further industry-wide cooperation is emphasized
This chapter discusses the status of the Price-Anderson Act which provides a means of compensation for members of the public who may be injured as a result of a nuclear incident at a licensed commercial power plant or a facility of the United States Government operated by a contractor. It describes the course of bills to extend the Act in 1987 and analyses some of the major issues of the debate (NEA) [fr
Full Text Available Contractors must carefully manage their cash outflows (e.g., for materials to enable their work and inflows (after the work to be profitable, particularly in an economy that is still recovering from the 2008-2012 recession that grew out of the mortgage crisis. Their importance for business success is undisputed, as bankruptcies due to insufficient cash flow underline. Therefore, this study investigated current business practices of electrical contracting companies of different sizes with respect to their financial planning and management. A detailed questionnaire was developed with best guidelines on survey studies and pilot testing. It was sent to members of the National Electrical Contractors Association. Respondent anonymity was ensured. The survey recorded demographics, business practices, operating conditions, and other important factors using 57 subquestions. Each section allowed feedback to clarify the numerical responses. Responses were well distributed across company sizes, so that the results are representative for the entire industry. The results indicated that contractors generally have a substantial amount of experience in financial decision making. Their approach is conservative and focuses on healthy growth. Yet, opportunities to fine-tune business practices are identified, e.g., immediate invoicing, considering discounts to accelerate payment receipts, attempting to negotiate and use favorable credit terms, reviewing payment performance, and performing frequent cash flow forecasts. Some of the differences in the responses can be attributed to different company sizes. To help especially smaller companies in planning their cash flow, a spreadsheet for implementation has been created.
The application of 29 CFR 1910.120, Hazardous Waste Operations and Emergency Response, at a complex former Department of Energy production facility has been extremely complicated. The requirements established by this Occupational Safety and Health Administration standard are extremely complex and have required a significant expenditure of resources to implement. A discussion of both the specific requirements of the standard are provided along with some of the implementation strategies employed and difficulties encountered. Additionally, a detailed discussion of the scope of the standard is presented. The Fernald Environmental Management Project (FEMP) formally the Feed Materials Production Center, at Fernald, Ohio is a former DOE production facility which has incurred a dramatic change in mission in becoming an environmental restoration site. Accompanying this mission change was the inclusion of the site on the National Priorities List (NPL). With the initiation of environmental restoration activities, a realization of the extent of application of 29 CFR 1910.120, Hazardous Waste Operations and Emergency Response, has been realized. The application of this OSHA mandated requirement at a 425 hectare facility employing over 1500 contractor and government personnel, with several hundred separate companies represented, has been extremely complicated. Compliance initially resulted in the stoppage of several projects and the delay of even more at considerable cost to the Department of Energy. This paper discusses how 29 CFR 1910.120 has been implemented at the FEMP, how the problems encountered have been solved and how continuing problems are being evaluated. The following topics are discussed separately: 1. Description and Scope of the Standard; 2. Site Program; 3. Site-Specific Safety and Health Plan; 4. Site Control; 5. Training; 6. Medical Surveillance; 7. Handling of Drums and Other Containers 8. Other Requirements
The growth of restorative justice has sparked debate over the future of the criminal justice system, which has historically adopted a retributive, punitive philosophy and advocated for an individualistic, treatment-orientated approach. This approach has over time failed to address the needs of crime victims, communities and.
Miranda J, Jose Eduardo
A great variety of techniques are used for the restoration of contaminated soils. The contamination is present by both organic and inorganic pollutants. Environmental conditions and soil characteristics should take into account in order to implement a remedial technique. The bioremediation technologies are showed as help to remove a variety of soil contaminants. (author) [es
Full Text Available Restoration can provide a wide range of direct and indirect benefits to society. However, there are very few projects that have attempted to properly quantify those benefits and present them in such a way that society is motivated to invest...
A. L. Johnson; K. A. Gano
The purpose of this report is to document the status of revegetation projects and natural resources mitigation efforts that have been conducted for remediated waste sites and other activities associated with the Comprehensive Environmental Response, Compensation, and Liability Act cleanup of National Priorities List waste sites at Hanford. One of the objectives of restoration is the revegetation of remediated waste sites to stabilize the soil and restore the land to native vegetation. The report documents the results of revegetation and mitigation monitoring conducted in 2006 and includes 11 revegetation/restoration projects, one revegetation/mitigation project, and 2 bat habitat mitigation projects.
C. T. Lindsey; K. A. Gano; R. D. Teel
This document details the results of revegetation and mitigation monitoring conducted in 2009, including 25 revegetation/restoration projects, one revegetation/mitigation project, and three bat mitigation projects.
Bodie, J.S.; Haymour, J. [Fraser Milner, Calgary, AB (Canada)
The many factors that should be considered when distinguishing between an independent contractor and an employee from the perspective of tax laws were discussed. Some of the major areas where disputes regarding relationships between the employee and the independent contractor arise were reviewed with particular emphasis on some of the dangers associated with a change in characterization of these types of relationships. Ways in which to guard against these dangers were also presented. The courts have established the following four tests to determine a contractor`s status: (1) the control test, (2) the economic reality test, (3) the business integration test, and (4) the ownership of tools test. The control tests looks to the degree of control that an employer/recipient of services possesses over the work that is to be performed. The economic reality test looks to whether the contractor is actually in business for himself and is risking a loss. The business integration test examines the relationship between employer and contractor in terms of how economically dependent the contractor is on the employer and whether the task the contractor carries on forms an integral part of the business of the employer. The last test examines who owns the tools used by the contractor to carry out his duties. This presentation also reviewed how employers and contractors are responsible for adhering to Revenue Canada tax laws and certain liabilities regarding income taxes, Employment Insurance (EI) premiums, Canada Pension Plan (CPP) contributions and other amounts.
Morris, Douglas R; DeYoung, Nathaniel J
While the United States Supreme Court's Jackson v. Indiana decision and most state statutes mandate determinations of incompetent defendants' restoration probabilities, courts and forensic clinicians continue to lack empirical evidence to guide these determinations and do not yet have a consensus regarding whether and under what circumstances incompetent defendants are restorable. The evidence base concerning the restoration likelihood of those defendants who fail initial restoration efforts is even further diminished and has largely gone unstudied. In this study, we examined the disposition of a cohort of defendants who underwent long-term competence restoration efforts (greater than six months) and identified factors related to whether these defendants were able to attain restoration and adjudicative success. Approximately two-thirds (n = 52) of the 81 individuals undergoing extended restoration efforts were eventually deemed restored to competence. Lengths of hospitalization until successful restoration are presented with implications for the reasonable length of time that restoration efforts should persist. Older individuals were less likely to be restored and successfully adjudicated, and individuals with more severe charges and greater factual legal understanding were more likely to be restored and adjudicated. The significance of these findings for courts and forensic clinicians is discussed.
John A. Stanturf; Callie J. Schweitzer; Stephen H. Schoenholtz; James P. Barnett; Charles K. McMahon; Donald J. Tomszak
Ecological restoration is generally accepted as the reestablishment of natural ecological processes that produce certain dynamic ecosystem properties of structure, function, and processes. But restore to what? The most frequently used conceptual model for the restoration process is the shift of conditions from some current (degraded) dynamic state to some past dynamic...
Full Text Available A review of the science and practice of ecosystem restoration led me to identify key ecological theories and concepts that are relevant to planning, implementing, and sustaining restoration efforts. From experience with actual restoration projects, I provide guidance for improving the restoration process. Despite an abundance of theory and guidance, restoration goals are not always achieved, and pathways toward targets are not highly predictable. This is understandable, since each restoration project has many constraints and unique challenges. To improve restoration progress, I advise that sites be designed as experiments to allow learning while doing. At least the larger projects can be restored in phases, each designed as experimental treatments to test alternative restoration approaches. Subsequent phases can then adopt one or more of the treatments that best achieved goals in earlier phases while applying new tests of other restoration measures. Both science and restoration can progress simultaneously. This phased, experimental approach (called “adaptive restoration” is an effective tool for improving restoration when monitoring, assessment, interpretation and research are integrated into the process.
Vargas Rios, Orlando
In this essay the principal concepts and methods applied on projects aimed at ecological restoration are reviewed, with emphasis on the relationship between conservation, biodiversity and restoration. The most common definitions are provided and the steps to take into account to develop projects on ecological restoration, which will be determined by the level of degradation of the ecosystem to be intervened.
Cardoso, Jorge André; Almeida, Paulo Júlio; Fischer, Alex; Phaxay, Somano Luang
The choice of the most appropriate restoration for anterior teeth is often a difficult decision. Numerous clinical and technical factors play an important role in selecting the treatment option that best suits the patient and the restorative team. Experienced clinicians have developed decision processes that are often more complex than may seem. Less experienced professionals may find difficulties making treatment decisions because of the widely varied restorative materials available and often numerous similar products offered by different manufacturers. The authors reviewed available evidence and integrated their clinical experience to select relevant factors that could provide a logical and practical guideline for restorative decisions in anterior teeth. The presented concept of restorative volume is based on structural, optical, and periodontal factors. Each of these factors will influence the short- and long-term behavior of restorations in terms of esthetics, biology, and function. Despite the marked evolution of esthetic restorative techniques and materials, significant limitations still exist, which should be addressed by researchers. The presented guidelines must be regarded as a mere orientation for risk analysis. A comprehensive individual approach should always be the core of restorative esthetic treatments. The complex decision process for anterior esthetic restorations can be clarified by a systematized examination of structural, optical, and periodontal factors. The basis for the proposed thought process is the concept of restorative volume that is a contemporary interpretation of restoration categories and their application. © 2012 Wiley Periodicals, Inc.
Full Text Available Chun-Hung Chu1, May L Mei,1 Chloe Cheung,1 Romesh P Nalliah2 1Faculty of Dentistry, The University of Hong Kong, Hong Kong, People's Republic of China; 2Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Boston, MA, USA Abstract: The tunnel restoration has been suggested as a conservative alternative to the conventional box preparation for treating proximal caries. The main advantage of tunnel restoration over the conventional box or slot preparation includes being more conservative and increasing tooth integrity and strength by preserving the marginal ridge. However, tunnel restoration is technique-sensitive and can be particularly challenging for inexperienced restorative dentists. Recent advances in technology, such as the contemporary design of dental handpieces with advanced light-emitting diode (LED and handheld comfort, offer operative dentists better vision, illumination, and maneuverability. The use of magnifying loupes also enhances the visibility of the preparation. The advent of digital radiographic imaging has improved dental imaging and reduced radiation. The new generation of restorative materials has improved mechanical properties. Tunnel restoration can be an option to restore proximal caries if the dentist performs proper case selection and pays attention to the details of the restorative procedures. This paper describes the clinical technique of tunnel restoration and reviews the studies of tunnel restorations. Keywords: operative, practice, tunnel preparation, composite, amalgam, glass ionomer
Hu, Y; Frieden, B R
In this paper, a method of restoring longitudinal images is developed. By using the transfer function for longitudinal objects, and inverse filtering, a longitudinal image may be restored. The Fourier theory and sampling theorems for transverse images cannot be used directly in the longitudinal case. A modification and reasonable approximation are introduced. We have numerically established a necessary relationship between just-resolved longitudinal separation (after inverse filtering), noise level, and the taking conditions of object distance and lens diameter. An empirical formula is also found to well-fit the computed results. This formula may be of use for designing optical systems which are to image longitudinal details, such as in robotics or microscopy.
Clark, D.; Franklin, J.; Mann, N.
We consider two different forms for a relativistic version of a linear restoring force. The pair comes from taking Hooke's law to be the force appearing on the right-hand side of the relativistic expressions: d"p"/d"t" or d"p"/d["tau"]. Either formulation recovers Hooke's law in the non-relativistic limit. In addition to these two forces, we…
Intrigued by the sound of another recently restored example, I attempted to bring a sadly abused, bottom-of-the-line, Hoseus-equipped banjo up to playable condition. Reminders, lessons learned, and the joy of (albeit crude) handiwork made it well- worth the purchase price. The actual sound and physics of the Hoseus contraption remain hidden in the complex interaction of the various parts, as demonstrated by the accompanying sound samples.
UNILEVER NV $112,089,508 292 UL 2000 11 MOOG, INC. $111,608,841 293 MOG.A 3728 11 ALON USA L.P. $111,102,800 296 ALJ 2911 11 COCA - COLA ENTERPRISES...audits and investigations. As a national leader in the fight against procurement fraud, Miller participates in the U.S. Attorney General’s Financial Fraud...Excessive Profits of Defense Contractors: Evidence and Determinants1 Chong Wang—Wang is an assistant professor of financial management in the
X - 7 a 2 n2m E X -) i=l m m Also under the assumptions of the CAPM , the relationship between an individual security’s expected rate of return and...Line 10 Thus, the CAPM , framed within certain simplifying assumptions , implies a linear relationship between return on investment in a company’s stock...Model ( CAPM ) is tested with regard to the same three sample groups of contractors. The third method is mean-variance analysis of both total and
This Quality Assurance Program Plan (QAPP) provides the primary requirements for the integration of quality functions into all Technical Assistance Contractor (TAC) Project organization activities. The QAPP is the written directive authorized by the TAc Program Manager to accomplish this task and to implement procedures that provide the controls and sound management practices needed to ensure TAC contractual obligations are met. The QA program is designed to use monitoring, audit, and surveillance functions as management tools to ensure that all Project organization functions are executed in a manner that will protect public health and safety, promote the success of the Project, and meet or exceed contract requirements
This books contains a collection of progress reports from the participating contractors in the wind energy R and D sub-programme within the JOULE (Joint Opportunities for Unconventional or Long term Energy supply) programme on non-nuclear energy and rational use of energy. The current wind energy programme consists of 25 multi-partner projects which are closely interrelated and cover a broad spectrum of topics. These are grouped within the following research areas: A: Wind measuring and modelling; B: Wind turbine experiments and utilisation; C: Development of components and models; D: Stand-Alone and offshore; E: Large-wind turbines
Full Text Available In the article the author deals with the basic theoretical statements and discussions about the practical use of restorative justice. She discusses the questions of introducing and application of restorative justice in order to reach the balance of interests between a victim, society and a delinquent. There is no unique statement about the restorative justice concept, so the authors make this concept by listing certain activities with rispect of standards and principles. Also she emphasizes the values of restorative justice process. A part of the article is dedicated to the standards for restorative justice that are harmonized with the international documents of human rights. .
Pendergrass, A.; Garvey, D.
The U.S. Department of Energy (DOE) prepares site-wide environmental impact statements (SWEIS) on sites that are to remain in operation in order to provide an estimate of the cumulative environmental impacts from projected future operations at the site. DOE has relied on outside contractors rather than the site management and operating (M&O) contractors to prepare EISs, in order to preclude the potential for conflict of interest. The site M&O contractors, who know the potential for conflict of interest. The site M&O contractors, who know the site best and are most familiar with existing information, are critical support for the contractor. The University of California (UC) is the site M&O contractor for Los Alamos National Laboratory (LANL) in Los Alamos, NM. The role of LANL (UC) personnel in DOE`s preparation process for the LANL SWEIS is described. 3 refs.
Yu, F T
Some of the physical interpretations about image restoration are discussed. From the theory of information the unrealizability of an inverse filter can be explained by degradation of information, which is due to distortion on the recorded image. The image restoration is a time and space problem, which can be recognized from the theory of relativity (the problem of image restoration is related to Heisenberg's uncertainty principle in quantum mechanics). A detailed discussion of the relationship between information and energy is given. Two general results may be stated: (1) the restoration of the image from the distorted signal is possible only if it satisfies the detectability condition. However, the restored image, at the best, can only approach to the maximum allowable time criterion. (2) The restoration of an image by superimposing the distorted signal (due to smearing) is a physically unrealizable method. However, this restoration procedure may be achieved by the expenditure of an infinite amount of energy.
Chu, Chun-Hung; Mei, May L; Cheung, Chloe; Nalliah, Romesh P
The tunnel restoration has been suggested as a conservative alternative to the conventional box preparation for treating proximal caries. The main advantage of tunnel restoration over the conventional box or slot preparation includes being more conservative and increasing tooth integrity and strength by preserving the marginal ridge. However, tunnel restoration is technique-sensitive and can be particularly challenging for inexperienced restorative dentists. Recent advances in technology, such as the contemporary design of dental handpieces with advanced light-emitting diode (LED) and handheld comfort, offer operative dentists better vision, illumination, and maneuverability. The use of magnifying loupes also enhances the visibility of the preparation. The advent of digital radiographic imaging has improved dental imaging and reduced radiation. The new generation of restorative materials has improved mechanical properties. Tunnel restoration can be an option to restore proximal caries if the dentist performs proper case selection and pays attention to the details of the restorative procedures. This paper describes the clinical technique of tunnel restoration and reviews the studies of tunnel restorations.
Scott, Judith A; Camden, Mindy
To develop a sustainable approach to Recovery Audit Contractor medical necessity readiness that mitigates the regulatory and financial risks of the organization. Acute care hospitals. Utilizing the model for improvement and plan-do-study-act methodology, this health system designed and implemented a medical necessity case management program. We focused on 3 areas for improvement: medical necessity review accuracy, review timeliness, and physician adviser participation for secondary reviews. Over several months, we improved accuracy and timeliness of our medical necessity reviews while also generating additional inpatient revenue for the health system. We successfully enhanced regulatory compliance and reduced our financial risks associated with Recovery Audit Contractor medical necessity audits. A successful medical necessity case management program can not only enhance regulatory compliance and reduce the amount of payments recouped by Medicare, but also generate additional inpatient revenue for your organization. With health care reform and accountable care organizations on the horizon, hospitals must find ways to protect and enhance revenue in order to carry out their missions. This is one way for case managers to help in that cause, to advocate for the care of their patients, and to bring value to the organization.
Petroleum fiscal terms in most countries are tougher than in the US, but these countries have more geological potential and still may be economically attractive. The market for exploration capital and technology is super competitive and getting more sophisticated. Governments are increasingly aware of the global market for exploration acreage or rehabilitation projects. For many oil companies, an important part of the negotiations is to secure terms acceptable to the potential partner. Knowing the market and what terms are realistic depends on a region's potential and other factors. Most countries developing petroleum fiscal systems are opting for the production sharing contract (PSC). This trend began in the 1960s. Now, nearly half of the countries with petroleum potential have a system based on the PSC. However, financial results could be the same in a royalty/tax arrangement. Economics depend primarily on division of profits or what is known as government/contractor take. The paper discusses contractor take, estimating take, Indonesian split, and take implications
Bodie, J.S.; Haymour, J.
The many factors that should be considered when distinguishing between an independent contractor and an employee from the perspective of tax laws were discussed. Some of the major areas where disputes regarding relationships between the employee and the independent contractor arise were reviewed with particular emphasis on some of the dangers associated with a change in characterization of these types of relationships. Ways in which to guard against these dangers were also presented. The courts have established the following four tests to determine a contractor's status: (1) the control test, (2) the economic reality test, (3) the business integration test, and (4) the ownership of tools test. The control tests looks to the degree of control that an employer/recipient of services possesses over the work that is to be performed. The economic reality test looks to whether the contractor is actually in business for himself and is risking a loss. The business integration test examines the relationship between employer and contractor in terms of how economically dependent the contractor is on the employer and whether the task the contractor carries on forms an integral part of the business of the employer. The last test examines who owns the tools used by the contractor to carry out his duties. This presentation also reviewed how employers and contractors are responsible for adhering to Revenue Canada tax laws and certain liabilities regarding income taxes, Employment Insurance (EI) premiums, Canada Pension Plan (CPP) contributions and other amounts
Bodie, J.S.; Haymour, J. [Fraser Milner, Calgary, AB (Canada)
The many factors that should be considered when distinguishing between an independent contractor and an employee from the perspective of tax laws were discussed. Some of the major areas where disputes regarding relationships between the employee and the independent contractor arise were reviewed with particular emphasis on some of the dangers associated with a change in characterization of these types of relationships. Ways in which to guard against these dangers were also presented. The courts have established the following four tests to determine a contractor's status: (1) the control test, (2) the economic reality test, (3) the business integration test, and (4) the ownership of tools test. The control tests looks to the degree of control that an employer/recipient of services possesses over the work that is to be performed. The economic reality test looks to whether the contractor is actually in business for himself and is risking a loss. The business integration test examines the relationship between employer and contractor in terms of how economically dependent the contractor is on the employer and whether the task the contractor carries on forms an integral part of the business of the employer. The last test examines who owns the tools used by the contractor to carry out his duties. This presentation also reviewed how employers and contractors are responsible for adhering to Revenue Canada tax laws and certain liabilities regarding income taxes, Employment Insurance (EI) premiums, Canada Pension Plan (CPP) contributions and other amounts.
G. Mathias Kondolf
Full Text Available Among the most visually striking river restoration projects are those that involve the creation of a new channel, often in a new alignment and generally with a form and dimensions that are different from those of the preproject channel. These channel reconstruction projects often have the objective of creating a stable, single-thread, meandering channel, even on rivers that were not historically meandering, on rivers whose sediment load and flow regime would not be consistent with such stable channels, or on already sinuous channels whose bends are not symmetrical. Such meandering channels are often specified by the Rosgen classification system, a popular restoration design approach. Although most projects of this type have not been subject to objective evaluation, completed postproject appraisals show that many of these projects failed within months or years of construction. Despite its, at best, mixed results, this classification and form-based approach continues to be popular because it is easy to apply, because it is accessible to those without formal training in fluvial geomorphology, and probably because it satisfies a deep-seated, although unrecognized, cultural preference for single-thread meandering channels. This preference is consistent with 18th-century English landscape theories, which held the serpentine form to be ideal and led to widespread construction of meandering channels on the country estates of the era. The preference for stability in restored channels seems to be widely accepted by practitioners and funders despite the fact that it is antithetical to research showing that dynamically migrating channels have the greatest ecological richness.
Günther, Andreas; Harding, Ulf; Gietzelt, Matthias; Gradaus, Frank; Tute, Erik; Fischer, Matthias
Due to limited resources, the 2010 European Resuscitation Council (ERC) guidelines could not be fully implemented in the Emergency Medical Services (EMS) of Brunswick, Germany. This is why implementation was prioritized according to local conditions. Thus, prehospital therapeutic hypothermia, mechanical chest compression and feedback systems were not established. Clinical data and long-term results were assessed by a QM system and room for improvement was identified. All attempted resuscitations from 2011 until 2014 were recorded and compared against the German Resuscitation Registry. Outcomes of adult patients following non-traumatic cardiac arrest were analyzed by year. 812 resuscitations were attempted (incidence 81.2/100,000 inhabitants/year). In the two years following full implementation since 2013 the discharge rate from hospital was 16.4 %, the discharge rate with a favorable neurologic outcome was 14.1 %, the 1-year survival rate was 14.4 % in 2013. A significant improvement of risk-adjusted ROSC rate during the investigation period was demonstrated. The discharge rates remained unchanged; the increase in the discharge rates paralleled the increase in CPR incidence. EMS response times were remarkably shorter. The implementation of the ERC guidelines chosen appears to be generally safe. Fast EMS response contributed to superior results. All links of the chain of survival showed room for improvement, especially the proportion of lay rescuer CPR and telephone-assisted CPR. The high CPR incidence might indicate room for improvement in prevention. Access to resuscitation care can hardly be evaluated. Age-related access to pre-hospital resuscitation seems to be appropriate. Copyright © 2015. Published by Elsevier GmbH.
Morgado, A.M.L.S.; Simoes, J.B.; Correia, C.M.
A good performance of high resolution nuclear spectrometry systems, at high pulse rates, demands restoration of baseline between pulses, in order to remove rate dependent baseline shifts. This restoration is performed by circuits named baseline restorers (BLRs) which also remove low frequency noise, such as power supply hum and detector microphonics. This paper presents simple circuits for baseline restoration based on a commercial current conveyor (CCII01). Tests were performed, on two circuits, with periodic trapezoidal shaped pulses in order to measure the baseline restoration for several pulse rates and restorer duty cycles. For the current conveyor based Robinson restorer, the peak shift was less than 10 mV, for duty cycles up to 60%, at high pulse rates. Duty cycles up to 80% were also tested, being the maximum peak shift 21 mV. The peak shift for the current conveyor based Grubic restorer was also measured. The maximum value found was 30 mV at 82% duty cycle. Keeping the duty cycle below 60% improves greatly the restorer performance. The ability of both baseline restorer architectures to reject low frequency modulation is also measured, with good results on both circuits
Chu, Chun-Hung; Cheung,; Nalliah,Romesh; Mei,May L
Chun-Hung Chu1, May L Mei,1 Chloe Cheung,1 Romesh P Nalliah2 1Faculty of Dentistry, The University of Hong Kong, Hong Kong, People's Republic of China; 2Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Boston, MA, USA Abstract: The tunnel restoration has been suggested as a conservative alternative to the conventional box preparation for treating proximal caries. The main advantage of tunnel restoration over the conventional box or slo...
An Independent Technical Review was conducted of the Environmental Restoration Project. The objective of the review was recommendations, from a commercial perspective, on a systems level path forward to safe, minimum cost and schedule project completion. The work presented represents the consensus analysis and recommendations of thirteen individuals with varied backgrounds, expertise, and experience. The ITR team recommends that the barriers to the opportunity described in the diagnosis be eliminated using an integrated DOE-Sandia system approach. Piecemeal changes will not result in the desired commercial efficiency. DOE needs to operate as the contracting agency for a Major System Acquisition. If it does not, commercial performance will not be achieved regardless of the contractor. Likewise, Sandia needs to establish and implement the necessary project structure and management systems to operate with commercial contractor like efficiency
Hammond, Barry D; Cooper, Jeril R; Lazarchik, David A
The importance of provisional restorations is often downplayed, as they are thought of by some as only "temporaries." As a result, a less-than-ideal provisional is sometimes fabricated, in part because of the additional chair time required to make provisional modifications when using traditional techniques. Additionally, in many dental practices, these provisional restorations are often fabricated by auxillary personnel who may not be as well trained in the fabrication process. Because provisionals play an important role in achieving the desired final functional and esthetic result, a high-quality provisional restoration is essential to fabricating a successful definitive restoration. This article describes a method for efficiently and predictably repairing both methacrylate and bis-acryl provisional restorations using flowable composite resin. By use of this relatively simple technique, provisional restorations can now be modified or repaired in a timely and productive manner to yield an exceptional result. Successful execution of esthetic and restorative dentistry requires attention to detail in every aspect of the case. Fabrication of high-quality provisional restorations can, at times, be challenging and time consuming. The techniques for optimizing resin provisional restorations as described in this paper are pragmatic and will enhance the delivery of dental treatment.
The Facilities Management contract at CERN, under the responsibility of ST Division, Group FM, is in charge of the maintenance and minor works on tertiary installations (i.e. all structures and installations that have no direct relation to the running of the accelerators) for the following trades: - Technical: heating, ventilation, air conditioning, plumbing, electricity, civil engineering (painting, roofing, glazing, blinds, fencing, masonry etc.), cleansing, passenger and goods lifts, automatic and powered doors, kitchen equipment, roads, signs, keys and locks, office furniture, - Services: waste collection, security, green areas, cleaning and sanitary supplies, disinfection, rodent control and insect control. Starting from the 1st June the present contractor will stop some activities that will be taken under its responsibility by the new one, INGEST Facility. Others activities will be moved on the 1st July. Minor perturbation in the service might occur. The contact number will not change and will be opera...
The Facilities Management contract at CERN, under the responsibility of ST Division, Group FM, is in charge of the maintenance and minor works on tertiary installations (i.e. all structures and installations that have no direct relation to the running of the accelerators) for the following trades: - Technical: heating, ventilation, air conditioning, plumbing, electricity, civil engineering (painting, roofing, glazing, blinds, fencing, masonry etc.), cleansing, passenger and goods lifts, automatic and powered doors, kitchen equipment, roads, signs, keys and locks, office furniture, - Services: waste collection, security, green areas, cleaning and sanitary supplies, disinfection, rodent control and insect control. Starting from the 1st June the present contractor will stop some activities that will be taken under its responsibility by the new one, INGEST Facility. The remaining activities (including cleaning) will be moved on the 1st July. Minor perturbation in the service might occur. The contact number will ...
Che Ahmad A.
Full Text Available The function of minimization of construction solid waste is to reduce or eliminates the adverse impacts on the environment and to human health. Due to the increase of population that leads to rapid development, there are possibilities of construction solid waste to be increased shortly from the construction works, demolition or renovation works. Materials such as wood, concrete, paint, brick, roofing, tiles, plastic and any other materials would contribute problem involving construction solid waste. Therefore, the proper waste minimization is needed to control the quantity of construction solid waste produced. This paper identifies the type of construction solid waste produced and discusses the waste minimization practice by the contractors at construction sites in Selangor, Kuala Lumpur and Putrajaya, Malaysia.
... provide a written plan for continuing the performance of essential contractor services identified in...; and (v) The approach for communicating expectations to contractor employees regarding their roles and... or other designated representative as expeditiously as possible and use its best efforts to cooperate...
Before the Office of River Protection can authorize proceeding with Phase 1B, the Tank Farm Contractor (TFC) must demonstrate readiness to retrieve and deliver the waste to the privatization contractor and to receive and dispose of the products and by-products returned from treatment. The TFC has organized their plans for providing these support services into the within the River Protection Project
...' Purchasing Systems Reviews AGENCIES: Department of Defense (DOD), General Services Administration (GSA), and... collection requirement concerning contractors' purchasing systems reviews. A request for public comments was..., Washington, DC 20405. Please cite OMB Control No. 9000-0132, Contractors' Purchasing Systems Review, in all...
... Products Requiring Federal Contractor Certification as to Forced/Indentured Child Labor Pursuant to... products requiring federal contractor certification as to the use of forced or indentured child labor. To.... 13126 (``Prohibition of Acquisition of Products Produced by Forced or Indentured Child Labor''), in...
... of products requiring federal contractor certification as to the use of forced or indentured child... DEPARTMENT OF LABOR Notice of Initial Determination Revising the List of Products Requiring Federal Contractor Certification as to Forced/Indentured Child Labor Pursuant to Executive Order 13126...
... List of Products Requiring Federal Contractor Certification as to Forced or Indentured Child Labor... Guidelines for Maintenance of the List of Products Requiring Federal Contractor Certification as to Forced or.... 13126 (``Prohibition of Acquisition of Products Produced by Forced or Indentured Child Labor''), in...
... Maintenance of the List of Products Requiring Federal Contractor Certification as to Forced or Indentured... DEPARTMENT OF LABOR Notice of Initial Determination Revising the List of Products Requiring Federal Contractor Certification as to Forced/Indentured Child Labor Pursuant to Executive Order 13126...
... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Review and correction of... contractors' property control systems. When the Government's property administrator determines that review and... administrator must review the system to determine whether the contractor will be able to meet the requirements...
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Performance of work by the... Performance of work by the contractor. (a) To assure adequate interest in and supervision of all work involved... contracting officer shall insert the clause at 52.236-1, Performance of Work by the Contractor, in...
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Performance of work by the... Performance of work by the contractor. The contracting officer shall insert the clause at 852.236-72, Performance of work by the contractor, in solicitations and contracts for construction that contain the FAR...
... conflicts of interest. 2052.209-72 Section 2052.209-72 Federal Acquisition Regulations System NUCLEAR... Clauses 2052.209-72 Contractor organizational conflicts of interest. As prescribed at 2009.570-5(a) and..., contracts, and simplified acquisitions of the types described; 2009.570-4(b): Contractor Organizational...
The availability of accommodation for contractors working on the proposed EDRP at Dounreay is discussed. It is predicted that the contractors could be accommodated without the need for special arrangement and with no adverse effect on the tourist industry. (U.K.)
...-by-case basis. If the time period expired due to negligence by the contractor, DOE may grant a... to avoid such negligence in the future. If a contractor is requesting an extension of time in which... Law 101-189, section 3133(d), and the DOE owned facility is involved in weapons related research and...
... foreign customers. 225.7303-1 Section 225.7303-1 Federal Acquisition Regulations System DEFENSE... for Foreign Military Sales 225.7303-1 Contractor sales to other foreign customers. If the contractor has made sales of the item required for the foreign military sale to foreign customers under...
must evaluate compliance with reporting requirements frequently so they can readily identify delinquent past performance reports.24 The FAR also...problems the contractor recovered from without impact to the contract/ order. There should have been no significant weaknesses identified. A...contractor had trouble overcoming and state how it impacted the Government. A Marginal rating should be supported by referencing the management tool
.... The essence of the definition cannot be changed substantially in the DFARS from that in the... recommended that the final rule define the contractor's obligation to cooperate, as in the mandatory... define the scope and limitations of the contractor's obligation to cooperate with Government...
... collection would violate the fundamental purposes of the Paperwork Reduction Act because of the burden it... subcontracting. We submit that fundamental preparation for a review is part of a contractor's normal course of... accounting of the contractors' time expenditure needed to prepare for a CPSR and respond to any contracting...
... Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS Case 2009-D025) AGENCY: Defense.../Pension Review from Procedures, Guidance, and Information to the Defense Acquisition Regulation Supplement..., February 23, 2006, moved requirements for Contractor Insurance/Pension Review (CIPR) from DFARS 242.7302 to...
... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Reimbursement of cost for transfer of contractor inventory. 245.608-7 Section 245.608-7 Federal Acquisition Regulations System... Reporting, Redistribution, and Disposal of Contractor Inventory 245.608-7 Reimbursement of cost for transfer...
... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5683-N-88] 30-Day Notice of Proposed Information Collection: Contractor's Requisition--Project Mortgages AGENCY: Office of the Chief Information... Title of Information Collection: Contractor's Requisition--Project Mortgages. OMB Approval Number: 2502...
... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5687-N-34] 60-Day Notice of Proposed Information Collection: Contractor's Requisition--Project Mortgages AGENCY: Office of the Assistant Secretary... Section A. A. Overview of Information Collection Title of Information Collection: Contractor's Requisition...
... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false First Article Approval... Clauses 52.209-3 First Article Approval—Contractor Testing. As prescribed in 9.308-1 (a) and (b), insert the following clause: First Article Approval—Contractor Testing (SEP 1989) [Contracting Officer shall...
..., DEPARTMENT OF LABOR NOTIFICATION OF EMPLOYEE RIGHTS UNDER FEDERAL LABOR LAWS OBLIGATIONS OF FEDERAL CONTRACTORS AND SUBCONTRACTORS; NOTIFICATION OF EMPLOYEE RIGHTS UNDER FEDERAL LABOR LAWS General Enforcement... 29 Labor 2 2010-07-01 2010-07-01 false Under what circumstances may a contractor be reinstated...
The Model Operating Plan for forestry contractors is a voluntary plan for compliance with the Migrant and Seasonal Agricultural Worker Protection Act (MSPA) of 1983, with amendments passed in 1996 and 1997. This plan is designed as a guide for forestry contractors who wish to comply with all federal, state, and local rules and regulations that govern their employer/...
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor's privileged financial and business information. 1845.7101-5 Section 1845.7101-5 Federal Acquisition Regulations System... 1845.7101-5 Contractor's privileged financial and business information. If a transfer of property...
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Testing performed by the... ADMINISTRATION COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS First Article Testing and Approval 509.308-1 Testing performed by the contractor. In FSS solicitations and contracts that will require...
... the contractor. (a)(1) The contracting officer shall insert the clause at 52.209-3, First Article... it is intended that the contract require (i) first article approval and (ii) that the contractor be... produce the first article and the production quantity at the same facility, the contracting officer shall...
Drupsteen, L.; Rasmussen, H.B.; Ustailieva, E.; Kampen, J. van
Working with multiple contractors in a shared workplace can introduce and increase safety risks due to complexity. The aim of this study was to explore how safety issues are recognized in a specific case and to identify whether clients and contractors perceive problems similarly. The safety issues
Full Text Available Lakes are suffering from different stress factors and need to be restored using different approaches. The eutrophication remains as the main water quality management problem for inland waters: both lakes and reservoirs. The way to curb the degradation is to stop the nutrient sources and to accelerate the restoration with help of in-lake technologies. Especially lakes with a long retention time need (eco- technological help to decrease the nutrient content in the free water. The microbial and other organic matter from sewage and other autochthonous biomasses, causes oxygen depletion, which has many adverse effects. In less developed countries big reservoirs function as sewage treatment plants. Natural aeration solves problems only partly and many pollutants tend to accumulate in the sediments. The acidification by acid rain and by pyrite oxidation has to be controlled by acid neutralizing technologies. Addition of alkaline chemicals is useful only for soft waters, and technologies for (microbial alkalinization of very acidic hardwater mining lakes are in development. The corrective measures differ from those in use for eutrophication control. The salinization and water shortage mostly occurs if more water is used than available. L. Aral, L. Tschad, the Dead Sea or L. Nasser belong to waters with most severe environmental problems on a global scale. Their hydrologic regime needs to be evaluated. The inflow of salt water at the bottom of some mining lakes adds to stability of stratification, and thus accumulation of hydrogen sulphide in the monimolimnion of the meromictic lakes. Destratification, which is the most used technology, is only restricted applicable because of the dangerous concentrations of the byproducts of biological degradation. The contamination of lakes with hazardous substances from industry and agriculture require different restoration technologies, including subhydric isolation and storage, addition of nutrients for better self
A short analysis of the main topics of the IPS Symposium Peatland Restoration and Reclamation, Duluth, Minnesota, USA, 1998 is given. It has been single-mindedly recommended in Estonia so far that harvested peatland surfaces should be levelled and outflows shut. But following these recommendations will lead to an unfounded formation of marshy areas with a very low growth of plants. The reclamation of harvested peatlands for agricultural purposes is expensive and there is no commercial need for agricultural land in today's Estonia now. In the author's opinion the foreflows and intermediate ditches should be left open which would favour the growth of the brushwood to grow later into the forest of commercial value. (author)
Full Text Available The magnitude of business dynamics has increased rapidly due to increased complexity, uncertainty, and risk of large-scale infrastructure projects. This fact made it increasingly tough to “go alone” into a contractor. As a consequence, joint venture contractors with diverse strengths and weaknesses cooperatively bid for bidding. Understanding project complexity and making decision on the optimal joint venture contractor is challenging. This paper is to study how to select joint venture contractors for undertaking large-scale infrastructure projects based on a multiattribute mathematical model. Two different methods are developed to solve the problem. One is based on ideal points and the other one is based on balanced ideal advantages. Both of the two methods consider individual difference in expert judgment and contractor attributes. A case study of Hong Kong-Zhuhai-Macao-Bridge (HZMB project in China is used to demonstrate how to apply these two methods and their advantages.
Riedl, Katrin; Jensen, Keith; Call, Josep; Tomasello, Michael
An important, and perhaps uniquely human, mechanism for maintaining cooperation against free riders is third-party punishment. Our closest living relatives, chimpanzees, will not punish third parties even though they will do so when personally affected. Until recently, little attention has been paid to how punishment and a sense of justice develop in children. Children respond to norm violations. They are more likely to share with a puppet that helped another individual as opposed to one who behaved harmfully, and they show a preference for seeing a harmful doll rather than a victim punished. By 6 years of age, children will pay a cost to punish fictional and real peers, and the threat of punishment will lead preschoolers to behave more generously. However, little is known about what motivates a sense of justice in children. We gave 3- and 5-year-old children--the youngest ages yet tested--the opportunity to remove items and prevent a puppet from gaining a reward for second- and third-party violations (experiment 1), and we gave 3-year-olds the opportunity to restore items (experiment 2). Children were as likely to engage in third-party interventions as they were when personally affected, yet they did not discriminate among the different sources of harm for the victim. When given a range of options, 3-year-olds chose restoration over removal. It appears that a sense of justice centered on harm caused to victims emerges early in childhood and highlights the value of third-party interventions for human cooperation. Copyright © 2015 Elsevier Ltd. All rights reserved.
Bandlow, Alisa [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Operations Research and Computational Analysis; Durfee, Justin David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Operations Research and Computational Analysis; Frazier, Christopher Rawls [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Operations Research and Computational Analysis; Gearhart, Jared Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Operations Research and Computational Analysis; Jones, Katherine A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Operations Research and Computational Analysis; Adair, Kristin Lynn [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Operations Research and Computational Analysis; Turgeon, Jennifer [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). High Confidence System Environments
The reports and test plans contained within this document serve as supporting materials to the activities listed within the “Contingency Contractor Optimization Tool – Prototype (CCOT-P) Verification & Validation Plan” . The activities included test development, testing, peer reviews, and expert reviews. The engineering prototype reviews were done for both the software and the mathematical model used in CCOT-P. Section 2 includes the peer and expert review reports, which summarize the findings from each of the reviews and document the resolution of any issues. Section 3 details the test plans that were followed for functional testing of the application through the interface. Section 4 describes the unit tests that were run on the code.
"This paper explores the links and connections between social work and restorative justice. After a brief description of social work, restorative justice and family group conferencing, I will explore some the complementary theoretical links and practice applications, critically examining the potential implications and opportunities for social work practitioners and academics in relation to practice." [author's abstract
R. Kasten Dumroese; Brian J. Palik; John A. Stanturf
It is not surprising to us that the topic of forest restoration is being discussed in the Journal of Forestry. It is a topic frequently bantered about in the literature; a quick search in Google Scholar for "forest restoration" generates more than 1 million hits. A significant portion of the debate centers on the search for succinct, holistic, universally...
Mainjot, Amélie; Vanheusden, Alain
Posterior ceramic bonded partial restorations are conservative and esthetic approaches for compromised teeth. Overlays constitute a less invasive alternative for tooth tissues than crown preparations. With inlays and onlays they are also indicated in case of full arch or quadrant rehabilitations including several teeth. This article screens indications and realization of this type of restorations.
Kenneth W. Outcalt
Because the longleaf ecosystem evolved with and is adapted to frequent fire, every 2 to 8 years, prescribed burning is often useful for restoring understory communities to a diverse ground layer of grasses, herbs, and small shrubs. This restoration provides habitat for a number of plant and animal species that are restricted to or found mostly in longleaf pine...
C. T. Lindsey; K. A. Gano
The purpose of this report is to document the status of revegetation projects and natural resources mitigation efforts that have been conducted for remediated waste sites and other activities associated with the Comprehensive Environmental Response, Compensation, and Liability Act cleanup of National Priorities List waste sites at Hanford. This report documents the results of revegetation and mitigation monitoring conducted in 2008 and includes 22 revegetation/restoration projects, one revegetation/mitigation project, and two bat habitat mitigation projects.
K. A. Gano; C. T. Lindsey
The purpose of this report is to document the status of revegetation projects and natural resources mitigation efforts that have been conducted for remediated waste sites and other activities associated with the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) cleanup of National Priorities List waste sites at Hanford. This report documents the results of revegetation and mitigation monitoring conducted in 2007 and includes 11 revegetation/restoration projects, one revegetation/mitigation project, and 3 bat habitat mitigation projects.
... 42 Public Health 2 2010-10-01 2010-10-01 false When CMS or its contractors may be a party to a... Hearings § 405.1012 When CMS or its contractors may be a party to a hearing. (a) CMS and/or one or more of... unrepresented beneficiary. (b) CMS and/or the contractor(s) advises the ALJ, appellant, and all other parties...
McCluskey, G.; Lloyd, G.; Stead, J.; Kane, J.; Riddell, S.; Weedon, E.
This paper explores definitions and understandings of restorative practices in education. It offers a critique of current theoretical models of restorative justice originally derived from the criminal justice system and now becoming popular in educational settings. It questions the appropriateness of these concepts as they are being introduced to…
... end products on the List of Products Requiring Contractor Certification as to Forced or Indentured... products on the List of Products Requiring Contractor Certification as to Forced or Indentured Child Labor... contracting officer must check the List of Products Requiring Contractor Certification as to Forced or...
... otherwise authorized by law or regulation. Any release containing contractor bid or proposal information or..., and marking of contractor bid or proposal information and source selection information. 3.104-4... marking of contractor bid or proposal information and source selection information. (a) Except as...
Stratton, Chris [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Walker, Iain S. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
This report is intended to provide home performance contractor trainers with a resource to keep both their workers and home residents safe and healthy. This document is an attempt to describe what we currently believe is safe, what we believe is unsafe, and what we’re unsure about. It is intended to identify health and safety issues and provide historical context and current understanding of both risks and mitigation strategies. In addition, it provides links to more in-depth resources for each issue. When we tighten the thermal envelope of a house to improve comfort and reduce energy use, we have to be sure that we are not compromising the indoor air quality of the home. This means identifying and mitigating or eliminating pollution sources before and after you make changes to the home. These sources can include materials and finishes in the home, exhaust gasses from combustion appliances, soil gasses such as radon, and moisture from a bathroom, kitchen, or unvented clothes dryer. Our first responsibility is to do no harm — this applies both to our clients and to our employees. Currently, there are many new products that are widely used but whose health effects are not well understood. Our in ability to have perfect information means the directive to do no harm can be difficult to obey. Each home is a little bit different, and in the face of a situation you’ve never encountered, it’s important to have a solid grasp of the fundamental concepts of building science when the hard and fast rules don’t apply . The home performance industry is gaining momentum, and has the potential to expand greatly as energy costs continue to rise. It is imperative that we remain vigilant about protecting the health and safety of our workers and our customers. It only takes a few news stories about a family that got sick after their home was tightened by a home performance contractor to scare off potential customers and taint the reputation of the entire industry. Good
Kinoshita, Seiya; Sato, Naoyoshi; Matsumoto, Naoya
Contractor evaluation methods in Japan's public works procurement, beginning with construction business licensure, going through biennial preliminary firm rating, up to project-by-project prequalification and comprehensive point rating, were developed during the period when public works were mostly procured through designated competitive bidding. It is essential to focus attention on contractor evaluation methods for introducing different types of procurement procedures which enhance the use of technological capabilities held by private businesses. An overall review of contractor evaluation procedures should be conducted in view of the present situation, where the open competitive bidding has become mainly used in combination with comprehensive evaluation, as well as to allow for further diversification of procurement methods. In Western countries, improvements have been made for the past several years in contractor evaluation procedures with more emphasis on "Value for Money." Advanced efforts made by these countries will be useful as a reference for overhauling Japan's contractor evaluation system. This study conducts a comparative review of contractor evaluation procedures for public procurement in Western countries such as the United States, the United Kingdom and France by identifying similarities and differences between those of Japan and the above mentioned countries. This reveals that a contractor's technical or professional ability is looked at separately from its economic and financial standing in those countries studied, and there is no case like Japan in which those two factors are integrated into one for evaluation.
Full Text Available There are many studies of contractor selection based on clients and the selection of suppliers by contractors. However, supplier selection specifically related to green construction projects has been much less studied. Green construction differs from conventional construction because of differences in its underlying principles and use of environmentally-friendly materials and technologies. This paper studies how procurers in contractor companies in Sweden adopt green projects and how contractor perception of supplier mastery of green knowledge affects supplier selection. The investigation is based on a set of semi-structured interviews conducted among three large contractors in Sweden. A main finding is that the perceived differences between green and conventional projects do not change supplier selection dramatically. An implication is that “greener projects” is a more appropriate denotation than “green project”. Evidence shows that suppliers’ green knowledge is an important factor in supplier selection, as respondents rated suppliers’ knowledge of green projects as very important, and to fix his, there was a consensus among respondents about the need for close collaboration between contractors and suppliers. To ensure knowledge acquisition from suppliers and to increase their competitive advantage over rivals, contractors collaborate with their suppliers in a partnering setting. It is anticipated that the results of this study will be used to fill the gap in the literature on supplier selection in green projects and can also be used for construction firms contemplating getting involved in green projects.
The overall objectives of the INEL Environmental Restoration (ER) Program management approach are to facilitate meeting mission needs through the successful implementation of a sound, and effective project management philosophy. This paper outlines the steps taken to develop the ER program, and explains further the implementing tools and processes used to achieve what can be viewed as fundamental to a successful program. The various examples provided will demonstrate how the strategies for implementing these operating philosophies are actually present and at work throughout the program, in spite of budget drills and organizational changes within DOE and the implementing contractor. A few of the challenges and successes of the INEL Environmental Restoration Program have included: a) completion of all enforceable milestones to date, b) acceleration of enforceable milestones, c) managing funds to reduce uncosted obligations at year end by utilizing greater than 99% of FY-95 budget, d) an exemplary safety record, e) developing a strategy for partial Delisting of the INEL by the year 2000, f) actively dealing with Natural Resource Damages Assessment issues, g) the achievement of significant project cost reductions, h) and implementation of a partnering charter and application of front end quality principles