Sample records for response poor readers

  1. Planning Behaviour in Good and Poor Readers

    Mahapatra, Shamita


    A group of 50 good readers and a group of 50 poor readers of Grade 5 matched for age and intelligence and selected on the basis of their proficiency in reading comprehension were tested for their competence in word reading and the process of planning at three different levels, namely, perceptual, memory and conceptual in order to study the…

  2. Text comprehension strategy instruction with poor readers

    Van den Bos, K.P.; Aarnoudse, C.C.; Brand-Gruwel, S.


    The goal of this study was to investigate the effects of teaching text comprehension strategies to children with decoding and reading comprehension problems and with a poor or normal listening ability. Two experiments are reported. Four text comprehension strategies, viz., question generation,

  3. Semantic and phonological coding in poor and normal readers.

    Vellutino, F R; Scanlon, D M; Spearing, D


    Three studies were conducted evaluating semantic and phonological coding deficits as alternative explanations of reading disability. In the first study, poor and normal readers in second and sixth grade were compared on various tests evaluating semantic development as well as on tests evaluating rapid naming and pseudoword decoding as independent measures of phonological coding ability. In a second study, the same subjects were given verbal memory and visual-verbal learning tasks using high and low meaning words as verbal stimuli and Chinese ideographs as visual stimuli. On the semantic tasks, poor readers performed below the level of the normal readers only at the sixth grade level, but, on the rapid naming and pseudoword learning tasks, they performed below the normal readers at the second as well as at the sixth grade level. On both the verbal memory and visual-verbal learning tasks, performance in poor readers approximated that of normal readers when the word stimuli were high in meaning but not when they were low in meaning. These patterns were essentially replicated in a third study that used some of the same semantic and phonological measures used in the first experiment, and verbal memory and visual-verbal learning tasks that employed word lists and visual stimuli (novel alphabetic characters) that more closely approximated those used in learning to read. It was concluded that semantic coding deficits are an unlikely cause of reading difficulties in most poor readers at the beginning stages of reading skills acquisition, but accrue as a consequence of prolonged reading difficulties in older readers. It was also concluded that phonological coding deficits are a probable cause of reading difficulties in most poor readers.

  4. Echoic memory processes in good and poor readers.

    Sipe, S; Engle, R W


    Four experiments were conducted to determine whether echoic memory plays a role in differences between good and poor readers. The first two experiments used a suffix procedure in which the subject is read a list of digits with either a tone control or the word go appended to the list. For lists that exceeded the length of the subjects memory span by one digit (i.e., that avoided ceiling effects), the poor readers showed a larger decrement in the suffix condition than did the good readers. The third experiment was directed at the question of whether the duration of echoic memory is different for good and poor readers. Children shadowed words presented to one ear at a rate determined to give 75-85% shadowing accuracy. The items presented to the nonattended ear were words and an occasional digit. At various intervals after the presentation of the digit, a light signaled that the subject was to cease shadowing and attempt to recall any digit that had occurred in the nonattended ear recently. Whereas good and poor readers recalled the digit equally if tested immediately after presentation, the poor readers showed a faster decline in recall of the digit as retention interval increased. A fourth experiment was conducted to determine whether the differences in echoic memory were specific to speech stimuli or occurred at a more basic level of aural persistence. Bursts of white noise were separated by 9-400 ms of silence and the subject was to say whether there were one or two sounds presented. There were no differences in detectability functions for good and poor readers.

  5. Verbal Processing Reaction Times in "Normal" and "Poor" Readers.

    Culbertson, Jack; And Others

    After it had been determined that reaction time (RT) was a sensitive measure of hemispheric dominance in a verbal task performed by normal adult readers, the reaction times of three groups of subjects (20 normal reading college students, 12 normal reading third graders and 11 poor reading grade school students) were compared. Ss were exposed to…

  6. How Do Fluent and Poor Readers' Endurance Differ in Reading?

    Bastug, Muhammet; Keskin, Hasan Kagan; Akyol, Mustafa


    It was observed in this research how endurance status of fluent readers and poor readers changed as the text became longer. 40 students of the primary school 4th-grade, 20 were fluent readers and other 20 were poor readers, participated in the research. A narrative text was utilised in the data collection process. Students' oral readings were…

  7. Subgrouping Poor Readers on the Basis of Individual Differences in Reading-Related Abilities

    Catts, Hugh W.; Hogan, Tiffany; Fey, Marc E.


    The present study investigated the use of the Reading Component Model to subgroup poor readers. A large sample of poor readers was identified in second grade and subgrouped on the basis of relative strengths and weaknesses in word recognition and listening comprehension. Although homogeneous subgroups were not identified, poor readers could be classified into four subgroups that differed significantly in reading-related abilities. Further analyses showed that poor readers' strengths and weakn...

  8. Reader responses to literary depictions of rape

    E.M. Koopman (Emy); M. Hilscher (Michelle); G.C. Cupchik (Gerald)


    textabstractThis study explored reader responses to different literary depictions of rape. Four literary excerpts were used and divided as aesthetic versus nonaesthetic (style) and allusive versus explicit (detail). The general question was how readers would react to literary fragments depicting

  9. Low self-concept in poor readers: prevalence, heterogeneity, and risk.

    McArthur, Genevieve; Castles, Anne; Kohnen, Saskia; Banales, Erin


    There is evidence that poor readers are at increased risk for various types of low self-concept-particularly academic self-concept. However, this evidence ignores the heterogeneous nature of poor readers, and hence the likelihood that not all poor readers have low self-concept. The aim of this study was to better understand which types of poor readers have low self-concept. We tested 77 children with poor reading for their age for four types of self-concept, four types of reading, three types of spoken language, and two types of attention. We found that poor readers with poor attention had low academic self-concept, while poor readers with poor spoken language had low general self-concept in addition to low academic self-concept. In contrast, poor readers with typical spoken language and attention did not have low self-concept of any type. We also discovered that academic self-concept was reliably associated with reading and receptive spoken vocabulary, and that general self-concept was reliably associated with spoken vocabulary. These outcomes suggest that poor readers with multiple impairments in reading, language, and attention are at higher risk for low academic and general self-concept, and hence need to be assessed for self-concept in clinical practice. Our results also highlight the need for further investigation into the heterogeneous nature of self-concept in poor readers.

  10. Low self-concept in poor readers: prevalence, heterogeneity, and risk

    Castles, Anne; Kohnen, Saskia; Banales, Erin


    There is evidence that poor readers are at increased risk for various types of low self-concept—particularly academic self-concept. However, this evidence ignores the heterogeneous nature of poor readers, and hence the likelihood that not all poor readers have low self-concept. The aim of this study was to better understand which types of poor readers have low self-concept. We tested 77 children with poor reading for their age for four types of self-concept, four types of reading, three types of spoken language, and two types of attention. We found that poor readers with poor attention had low academic self-concept, while poor readers with poor spoken language had low general self-concept in addition to low academic self-concept. In contrast, poor readers with typical spoken language and attention did not have low self-concept of any type. We also discovered that academic self-concept was reliably associated with reading and receptive spoken vocabulary, and that general self-concept was reliably associated with spoken vocabulary. These outcomes suggest that poor readers with multiple impairments in reading, language, and attention are at higher risk for low academic and general self-concept, and hence need to be assessed for self-concept in clinical practice. Our results also highlight the need for further investigation into the heterogeneous nature of self-concept in poor readers. PMID:27867764

  11. Evidence for deficits in the temporal attention span of poor readers.

    Visser, Troy A W


    While poor reading is often associated with phonological deficits, many studies suggest that visual processing might also be impaired. In particular, recent research has indicated that poor readers show impaired spatial visual attention spans in partial and whole report tasks. Given the similarities between competition-based accounts for reduced visual attention span and similar explanations for impairments in sequential object processing, the present work examined whether poor readers show deficits in their "temporal attention span"--that is, their ability to rapidly and accurately process sequences of consecutive target items. Poor and normal readers monitored a sequential stream of visual items for two (TT condition) or three (TTT condition) consecutive target digits. Target identification was examined using both unconditional and conditional measures of accuracy in order to gauge the overall likelihood of identifying a target and the likelihood of identifying a target given successful identification of previous items. Compared to normal readers, poor readers showed small but consistent deficits in identification across targets whether unconditional or conditional accuracy was used. Additionally, in the TTT condition, final-target conditional accuracy was poorer than unconditional accuracy, particularly for poor readers, suggesting a substantial cost arising from processing the previous two targets that was not present in normal readers. Mirroring the differences found between poor and normal readers in spatial visual attention span, the present findings suggest two principal differences between the temporal attention spans of poor and normal readers. First, the consistent pattern of reduced performance across targets suggests increased competition amongst items within the same span for poor readers. Second, the steeper decline in final target performance amongst poor readers in the TTT condition suggests a reduction in the extent of their temporal attention

  12. Evidence for deficits in the temporal attention span of poor readers.

    Troy A W Visser

    Full Text Available While poor reading is often associated with phonological deficits, many studies suggest that visual processing might also be impaired. In particular, recent research has indicated that poor readers show impaired spatial visual attention spans in partial and whole report tasks. Given the similarities between competition-based accounts for reduced visual attention span and similar explanations for impairments in sequential object processing, the present work examined whether poor readers show deficits in their "temporal attention span"--that is, their ability to rapidly and accurately process sequences of consecutive target items.Poor and normal readers monitored a sequential stream of visual items for two (TT condition or three (TTT condition consecutive target digits. Target identification was examined using both unconditional and conditional measures of accuracy in order to gauge the overall likelihood of identifying a target and the likelihood of identifying a target given successful identification of previous items. Compared to normal readers, poor readers showed small but consistent deficits in identification across targets whether unconditional or conditional accuracy was used. Additionally, in the TTT condition, final-target conditional accuracy was poorer than unconditional accuracy, particularly for poor readers, suggesting a substantial cost arising from processing the previous two targets that was not present in normal readers.Mirroring the differences found between poor and normal readers in spatial visual attention span, the present findings suggest two principal differences between the temporal attention spans of poor and normal readers. First, the consistent pattern of reduced performance across targets suggests increased competition amongst items within the same span for poor readers. Second, the steeper decline in final target performance amongst poor readers in the TTT condition suggests a reduction in the extent of their

  13. Improving the Performance of Poor Readers through Autogenic Relaxation Training.

    Frey, Herbert


    Reports that the addition of 15 minutes of relaxation training to weekly remedial reading periods for disabled readers throughout a school year raised concentration levels and decreased anxiety, neuroticism, and number of reading errors. Describes a few types of relaxation exercises that may be helpful. (ET)

  14. Is It Lateralization, Processing Strategies, or Both That Distinguishes Good And Poor Readers?

    Watson, E. Selman; Engle, Randall W.


    Two experiments investigated whether poor readers eventually establish a dichotic right ear advantage as predicted by a maturational lag theory. The first studied developmental differences in dichotic listening for normal and poor readers when the order of reporting simultaneously presented items was unconstrained; the second controlled for order…

  15. Developmental Trajectories for Children With Dyslexia and Low IQ Poor Readers


    Reading difficulties are found in children with both high and low IQ and it is now clear that both groups exhibit difficulties in phonological processing. Here, we apply the developmental trajectories approach, a new methodology developed for studying language and cognitive impairments in developmental disorders, to both poor reader groups. The trajectory methodology enables identification of atypical versus delayed development in datasets gathered using group matching designs. Regarding the cognitive predictors of reading, which here are phonological awareness, phonological short-term memory (PSTM) and rapid automatized naming (RAN), the method showed that trajectories for the two groups diverged markedly. Children with dyslexia showed atypical development in phonological awareness, while low IQ poor readers showed developmental delay. Low IQ poor readers showed atypical PSTM and RAN development, but children with dyslexia showed developmental delay. These divergent trajectories may have important ramifications for supporting each type of poor reader, although all poor readers showed weakness in all areas. Regarding auditory processing, the developmental trajectories were very similar for the two poor reader groups. However, children with dyslexia demonstrated developmental delay for auditory discrimination of Duration, while the low IQ children showed atypical development on this measure. The data show that, regardless of IQ, poor readers have developmental trajectories that differ from typically developing children. The trajectories approach enables differences in trajectory classification to be identified across poor reader group, as well as specifying the individual nature of these trajectories. PMID:27110928

  16. Towards a Culturally Situated Reader Response Theory

    Brooks, Wanda; Browne, Susan


    This article describes a theory of how culture enables literary interpretations of texts. We begin with a brief overview of the reader response field. From there, we introduce the theory and provide illustrative participant data examples. These data examples illustrate the four cultural positions middle grade students in our research assumed when…

  17. Do good and poor readers make use of morphemic structure in English word recognition?

    Lynne G. Duncan


    Full Text Available The links between oral morphological awareness and the use of derivational morphology are examined in the English word recognition of 8-year-old good and poor readers. Morphological awareness was assessed by a sentence completion task. The role of morphological structure in lexical access was examined by manipulating the presence of embedded words and suffixes in items presented for lexical decision. Good readers were more accurate in the morphological awareness task but did not show facilitation for real derivations even though morpho-semantic information appeared to inform their lexical decisions. The poor readers, who were less accurate, displayed a strong lexicality effect in lexical decision and the presence of an embedded word led to facilitation for words and inhibition for pseudo-words. Overall, the results suggest that both good and poor readers of English are sensitive to the internal structure of written words, with the better readers showing most evidence of morphological analysis.

  18. Do Poor Readers Feel Angry, Sad, and Unpopular?

    Morgan, Paul L.; Farkas, George; Wu, Qiong


    We investigated whether being poorly skilled in reading contributes to children's reported feelings of anger, distractibility, anxiety, sadness, loneliness, and social isolation. Data were analyzed from a longitudinal subsample of children (N = 3,308) participating in the Early Childhood Longitudinal Study-Kindergarten Cohort. Multilevel logistic…

  19. A comparison of the language skills of ELLs and monolinguals who are poor decoders, poor comprehenders, or normal readers.

    Geva, Esther; Massey-Garrison, Angela


    The overall objective of this article is to examine how oral language abilities relate to reading profiles in English language learners (ELLs) and English as a first language (EL1) learners, and the extent of similarities and differences between ELLs and EL1s in three reading subgroups: normal readers, poor decoders, and poor comprehenders. The study included 100 ELLs and 50 EL1s in Grade 5. The effect of language group (ELL/EL1) and reading group on cognitive and linguistic skills was examined. Except for vocabulary, there was no language group effect on any measure. However, within ELL and EL1 alike, significant differences were found between reading groups: Normal readers outperformed the two other groups on all the oral language measures. Distinct cognitive and linguistic profiles were associated with poor decoders and poor comprehenders, regardless of language group. The ELL and EL1 poor decoders outperformed the poor comprehenders on listening comprehension and inferencing. The poor decoders displayed phonological-based weaknesses, whereas the poor comprehenders displayed a more generalized language processing weakness that is nonphonological in nature. Regardless of language status, students with poor decoding or comprehension problems display difficulties with various aspects of language.

  20. Poor readers but compelled to read: Stroop effects in developmental dyslexia.

    Faccioli, Chiara; Peru, Andrea; Rubini, Elena; Tassinari, Giancarlo


    We studied a group of 24 children with dyslexia in second to fifth primary school grades by using a discrete-trial computerized version of the Stroop Color-Word Test. Since the classic Stroop effect depends on the interference of reading with color naming, one would expect these children to show no interference or, at least, less interference than normal readers. Children with dyslexia showed, however, a Stroop effect larger than normal readers of the same age. This suggests that reading, although difficult and slow, is an inescapable step that precedes naming both in poor and in normal readers.

  1. Conceptual versus Perceptual Text Processing Strategies: Differences between Good and Poor Readers.

    Shepard, Charlene R.; Reynolds, Ralph E.

    Investigating the selective attention strategy, a study examined the type of attention allocated to important information by good and poor readers. Also tested was the methodological validity of using a conceptual (word recognition) perceptual (tachistoscopic word flash) task as a means of investigating the types of information processing that may…

  2. Developmental Trajectories for Children with Dyslexia and Low IQ Poor Readers

    Kuppen, Sarah E. A.; Goswami, Usha


    Reading difficulties are found in children with both high and low IQ and it is now clear that both groups exhibit difficulties in phonological processing. Here, we apply the developmental trajectories approach, a new methodology developed for studying language and cognitive impairments in developmental disorders, to both poor reader groups. The…

  3. Imitated prosodic fluency predicts reading comprehension ability in good and poor high school readers

    Mara Breen


    Full Text Available Researchers have established a relationship between beginning readers’ silent comprehension ability and their prosodic fluency, such that readers who read aloud with appropriate prosody tend to have higher scores on silent reading comprehension assessments. The current study was designed to investigate this relationship in two groups of high school readers: Specifically Poor Comprehenders (SPCs, who have adequate word level and phonological skills but poor reading comprehension ability, and a group of age- and decoding skill-matched controls. We compared the prosodic fluency of the two groups by determining how effectively they produced prosodic cues to syntactic and semantic structure in imitations of a model speaker’s production of syntactically and semantically varied sentences. Analyses of pitch and duration patterns revealed that speakers in both groups produced the expected prosodic patterns; however, controls provided stronger durational cues to syntactic structure. These results demonstrate that the relationship between prosodic fluency and reading comprehension continues past the stage of early reading instruction. Moreover, they suggest that prosodically fluent speakers may also generate more fluent implicit prosodic representations during silent reading, leading to more effective comprehension.

  4. Synthetic phonics and decodable instructional reading texts: How far do these support poor readers?

    Price-Mohr, Ruth Maria; Price, Colin Bernard


    This paper presents data from a quasi-experimental trial with paired randomisation that emerged during the development of a reading scheme for children in England. This trial was conducted with a group of 12 children, aged 5-6, and considered to be falling behind their peers in reading ability and a matched control group. There were two intervention conditions (A: using mixed teaching methods and a high percentage of non-phonically decodable vocabulary; P: using mixed teaching methods and low percentage of non-decodable vocabulary); allocation to these was randomised. Children were assessed at pre- and post-test on standardised measures of receptive vocabulary, phoneme awareness, word reading, and comprehension. Two class teachers in the same school each selected 6 children, who they considered to be poor readers, to participate (n = 12). A control group (using synthetic phonics only and phonically decodable vocabulary) was selected from the same 2 classes based on pre-test scores for word reading (n = 16). Results from the study show positive benefits for poor readers from using both additional teaching methods (such as analytic phonics, sight word vocabulary, and oral vocabulary extension) in addition to synthetic phonics, and also non-decodable vocabulary in instructional reading text. Copyright © 2018 John Wiley & Sons, Ltd.

  5. Reader Response and the Verbal Icon: Implications for English Education.

    Harker, W. John

    During the past 15 years, a fundamental change has taken place in literary criticism, with a decline in New Criticism (literature viewed as a public object) and an increase in reader response criticism (literature viewed as a private experience). New Critics considered the meaning of a literary text to exist within the text as an independent and…

  6. Reading Comprehension: A Computerized Intervention with Primary-age Poor Readers.

    Horne, Joanna Kathryn


    The current study investigates the effectiveness of a computerized reading comprehension programme on the reading accuracy, reading comprehension and reading rate of primary-age poor readers. There is little published literature relating to computerized reading interventions in UK primary schools, and no previous studies have investigated the Comprehension Booster programme. Thirty-eight children (26 boys and 12 girls; aged 6:7 to 11:0) from two schools in East Yorkshire, UK, took part. Half of the participants (the intervention group) undertook the Comprehension Booster programme for a 6-week period, whilst the other half (the control group) continued with their usual teaching. Significant effects of the intervention were found, with increases in reading accuracy and reading comprehension for the intervention group. It is concluded that computerized reading programmes can be effective in improving reading skills, and these are particularly useful for pupils with reading difficulties in disadvantaged areas, where resources are limited and family support in reading is lower. However, such programmes are not a replacement for good teaching, and regular monitoring of children with reading difficulties is required. Further research is necessary to compare the programme used here to other conventional and computerized intervention programmes, using a larger sample. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  7. Processamento cognitivo em crianças com e sem dificuldades de leitura Cognitive skills in children: comparing good readers and poor readers

    Alessandra Gotuzo Seabra Capovilla


    Full Text Available Para buscar identificar habilidades cognitivas mais freqüentemente prejudicadas nas dificuldades de leitura, 90 crianças de pré-escola e 1ª Série foram avaliadas em leitura, escrita, consciência fonológica, memória fonológica, vocabulário, aritmética, processamento visual e seqüenciamento. Comparando as habilidades de bons e maus leitores (acima e abaixo de 1 desvio-padrão em relação à média, respectivamente, observou-se que bons leitores foram significativamente superiores em escrita, consciência fonológica, vocabulário, memória fonológica e memória visual. Resultados sugerem uma relação funcional e forte entre processamento fonológico e leitura; funcional e moderada entre processamento seqüencial, aritmética e leitura; e fraca e correlacional entre processamento visual e leitura.To identify cognitive skills that may be diminished in reading difficulties, 90 preschoolers and first graders were tested in reading, spelling, phonological awareness, phonological memory, vocabulary, arithmetic, visual processing, and sequential processing. Comparison between good readers and poor readers (above and below one standard deviation, respectively, revealed that good readers were significantly superior to poor readers in spelling, phonological awareness, vocabulary, phonological memory and visual memory. Results suggest strong functional relationship between phonological processing and reading, moderate functional relationships between sequential processing and arithmetic on one hand and reading on the other, and weak correlation between visual processing and reading.

  8. Eye-Movement Patterns and Reader Characteristics of Students with Good and Poor Performance When Reading Scientific Text with Diagrams

    Jian, Yu-Cin


    This study investigated the cognitive processes and reader characteristics of sixth graders who had good and poor performance when reading scientific text with diagrams. We first measured the reading ability and reading self-efficacy of sixth-grade participants, and then recorded their eye movements while they were reading an illustrated…

  9. Reading Ability and Memory Span: Long-Term Memory Contributions to Span for Good and Poor Readers.

    McDougall, Sine J. P.; Donohoe, Rachael


    Investigates the extent to which differences in memory span for good and poor readers can be explained by differences in a long-term memory component to span as well as by differences in short-term memory processes. Discusses the nature of the interrelationships between memory span, reading and measures of phonological awareness. (SG)

  10. Severity of Emotional and Behavioral Problems among Poor and Typical Readers.

    Arnold, Elizabeth Mayfield; Goldston, David B.; Walsh, Adam K.; Reboussin, Beth A.; Daniel, Stephanie Sergent; Hickman, Enith; Wood, Frank B.


    The purpose of this study was to examine the severity of behavioral and emotional problems among adolescents with poor and typical single word reading ability (N = 188) recruited from public schools and followed for a median of 2.4 years. Youth and parents were repeatedly assessed to obtain information regarding the severity and course of symptoms…

  11. An Analysis of Modular Instruction of Newspaper Reading Skills to Poor Readers in Junior High School.

    Berryman, Charles

    Fifty instructional modules designed to improve newspaper reading skills were field tested in this study. During a 50-day period, modules were used by Wilkes County, Georgia teachers as they saw fit in seventh, eighth, and ninth grade classes primarily for 338 students with poor reading skills. In summary, the effectiveness of the instructional…

  12. Executive Functioning and Reading Achievement in School: A study of Brazilian Children Assessed by Their Teachers as Poor Readers

    Pascale M. J. Engel de Abreu


    Full Text Available This study examined executive functioning and reading achievement in 106 6- to 8-year-old Brazilian children from a range of social backgrounds of whom approximately half lived below the poverty line. A particular focus was to explore the executive function profile of children whose classroom reading performance was judged below standard by their teachers and who were carefully matched to controls on chronological age, sex, school type (Private or Public, domicile (Salvador/BA or São Paulo/SP, and socioeconomic status. Children completed a battery of 12 executive function tasks that were conceptually tapping cognitive flexibility, working memory, inhibition, and selective attention. Each executive function domain was assessed by several tasks. Principal component analysis extracted four factors that were labeled Working Memory/Cognitive Flexibility, Interference Suppression, Selective Attention, and Response Inhibition. Individual differences in executive functioning components made differential contributions to early reading achievement. The Working Memory/Cognitive Flexibility factor emerged as the best predictor of reading. Group comparisons on computed factor scores showed that the struggling readers presented limitations in Working Memory/Cognitive Flexibility, but not in other executive function components, compared to more skilled readers. These results validate the account that working memory capacity provides a crucial building block for the development of early literacy skills and extends it to a population of early readers of Portuguese from Brazil. The study suggests that deficits in working memory/cognitive flexibility might represent one contributing factor to reading difficulties in early readers which might have important implications for interventions for children at risk of school failure.

  13. Reading in Two Orthographies: A Cross-Linguistic Study of Dutch Average and Poor Readers Who Learn English as a Second Language

    Morfidi, Eleni; van der Leij, Aryan; de Jong, Peter F.; Scheltinga, Femke; Bekebrede, Judith


    The present study investigated the reading of secondary school students in their first and second language (L1, L2). Twenty-six average and twenty-six poor readers matched on age, gender, listening and reading comprehension participated. They were native Dutch speakers who started learning English at secondary school (grade 7). We examined whether…

  14. Effectiveness of Critical Thinking Skills for English Literature Study with Reader Response Theory: Review of Literature

    Farah Qamar


    Full Text Available Since Socrates’ time, reasoning is considered valuable for the justification of speaker’s belief along with Thomas Aquinas’ testing of his thinking to answer his own thinking. Critical thinking has been part of discussion among the educators for its significance and application for last many decades. Many educators have conducted researches on the assessment of critical thinking within a domain or across the domain in order to test students’ critical thinking skills and its effect on their learning. Similarly, critical thinking is highly valuable for the study of literature as it explicitly asked for learners’ beliefs, perceptions, and judgments in order to remove the ambiguity of thought. Perfection of thought can be achieved with the use of critical thinking skills while training of mind needs interaction between literary text and the reader as literature has the capacity to achieve mental traits specified to critical thinking. Accordingly, this report presents a relationship between critical thinking skills and English literature study along with reader response theory techniques considering that without the use of critical thinking skills and reader response theory, study of literature is haphazard hence for the application of reader response theory, literary text is inevitable. In essence, I aim to highlight the effectiveness of critical thinking skills for the study of literature while emphasizing the significance of reader response theory which is also inevitable for the study of literature and for the use of critical thinking skills.

  15. Reader's Response: What Is a SoTL?

    Griebenow, Kai


    In this response to, "SoTL Commons Conference: A Spirit of Inquiry" (Margaret Davis, Kera Watkins, and Deborah Allen, "International Journal for the Scholarship of Teaching and Learning,"v3 n2 Jul 2009), Griebenow adds his personal impressions as an "SOTL newbie." He states that many scientists have an idea of…

  16. Outcome of poor response Paediatric AML using early SCT

    Wareham, Neval E; Heilmann, Carsten; Abrahamsson, Jonas


    ) or > 5% blasts after AM (n = 14, refractory disease). Poor response patients received intensively timed induction and proceeded to SCT when a donor was available. RESULTS: Thirty-one of 267 evaluable patients (12%) had a poor response. SCT was performed in 25; using matched unrelated donors in 13......BACKGROUND: Children with poor response acute myeloid leukaemia (AML) generally have a very poor outcome. Allogeneic stem cell transplantation (SCT) is often recommended for these children but the benefit is unclear. The aim of this study was to investigate survival for poor response AML patients...... treated with SCT. MATERIAL AND METHODS: Treatment was given according to the NOPHO-AML 2004 protocol. All patients received AIET (Cytarabine, Idarubicin, Etoposide, Thioguanine) and AM (Cytarabine, Mitoxantrone) as induction. We included poor response defined as > 15% blasts on day 15 after AIET (n = 17...

  17. A Rhythmic Musical Intervention for Poor Readers: A Comparison of Efficacy with a Letter-Based Intervention

    Bhide, Adeetee; Power, Alan; Goswami, Usha


    There is growing evidence that children with reading difficulties show impaired auditory rhythm perception and impairments in musical beat perception tasks. Rhythmic musical interventions with poorer readers may thus improve rhythmic entrainment and consequently improve reading and phonological skills. Here we compare the effects of a musical…

  18. Reader-Responses of Pregnant Adolescents and Teenage Mothers to Young Adult Novels Portraying Protagonists with Problems Similar and Dissimilar to the Readers'.

    Poe, Elizabeth Ann

    Applying reader response theory, a study explored the responses of 19 pregnant adolescents and teenage mothers to two dissimilar young adult novels, one about teenage pregnancy and one about adolescent alcoholism. Quantitative analysis, using a modified version of the Purves-Rippere (1968) system, and qualitative analysis of written answers to…

  19. The Effects of Music on Students Engaged in Reader Response Strategies.

    Kagan, Susan C.

    This study examined the effects of background classical music on silent reading in a sixth grade class, in order to determine the amount and type of influence it would have on the reader's written response to what was read. Thirty-four suburban sixth graders from two history classes were selected for this study. The data was obtained over a period…

  20. Reader-Response Theory: An Analysis of a Work of Chinese Post Modern Art.

    Ma, Yan


    Illustrates reader-response theory by discussing a piece of Chinese art, "A Book from the Sky." Examines the relationship between and among viewer, text or artwork, and artist; and attempts to determine the meanings viewers of different ages, genders, ethnicity, and professions construct in reaction to the work of art and to postmodern…

  1. A New Kind of Research Paper: Bridging the Gap between Reader Response and Formal Critical Analysis.

    Hamilton-Johnson, Lisa


    Explores how two-year college students may be assisted in the transition from reader response criticism to literary analysis and research paper writing. Proposes a heuristic that requires student researchers to draw on previous student essays on their topic. (TB)

  2. Outcome of poor response paediatric AML using early SCT.

    Wareham, Neval E; Heilmann, Carsten; Abrahamsson, Jonas; Forestier, Erik; Gustafsson, Britt; Ha, Shau-Yin; Heldrup, Jesper; Jahnukainen, Kirsi; Jónsson, Ólafur G; Lausen, Birgitte; Palle, Josefine; Zeller, Bernward; Hasle, Henrik


    Children with poor response acute myeloid leukaemia (AML) generally have a very poor outcome. Allogeneic stem cell transplantation (SCT) is often recommended for these children but the benefit is unclear. The aim of this study was to investigate survival for poor response AML patients treated with SCT. Treatment was given according to the NOPHO-AML 2004 protocol. All patients received AIET (Cytarabine, Idarubicin, Etoposide, Thioguanine) and AM (Cytarabine, Mitoxantrone) as induction. We included poor response defined as > 15% blasts on day 15 after AIET (n = 17) or > 5% blasts after AM (n = 14, refractory disease). Poor response patients received intensively timed induction and proceeded to SCT when a donor was available. Thirty-one of 267 evaluable patients (12%) had a poor response. SCT was performed in 25; using matched unrelated donors in 13, matched sibling donors in 6, cord blood donor in 4, and haploidentical donor in two. The median follow-up for the 31 poor responding patients was 2.6 years (range 0.4 - 8.1 years) and 3-year probability of survival 70% (95% CI 59-77%). The poor responders in the NOPHO-AML 2004 protocol had a favourable prognosis treated with time-intensive induction followed by SCT. © 2012 John Wiley & Sons A/S.

  3. Increasing Word-Reading Speed in Poor Readers: No Additional Benefits of Explicit Letter-Cluster Training

    Marinus, Eva; de Jong, Peter; van der Leij, Aryan


    The present study examined whether explicit training of letter-clusters leads to more gains in word-reading speed than training of the separate letters of the same clusters. Ninety-nine poor reading second-grade children were randomly assigned to a cluster-training, a parallel letter-training, or a no-training condition. The cluster-training…

  4. RTI and the Adolescent Reader: Responsive Literacy Instruction in Secondary Schools (Middle and High School). Language & Literacy Series Practitioners Bookshelf

    Brozo, William G.


    "RTI and the Adolescent Reader" focuses exclusively on Response to Intervention (RTI) for literacy at the secondary level. In this accessible guide, William Brozo defines RTI and explains why and how it is considered a viable intervention model for adolescent readers. He analyzes the authentic structural, political, cultural, and teacher…

  5. One text, many stories: The (irrelevance of reader-response criticism for apocryphal literature in the Septuagint

    S. Philip Nolte


    Full Text Available This article investigated the value of reader-response theory for the reading of apocryphal texts in the Septuagint. The groundbreaking work on reader-response theory developed by Wolfgang Iser in his book The Act of Reading: A Theory of Aesthetic Response, written in 1978 served as the theoretical point of departure. Although the reader-response theory has been scrutinised and criticised heavily during the last three decades, Iser made a very valuable contribution to the reading of literature. My assumption is that religious texts have to be read in the same way as other literature and therefore literary theories such as Iser’s can be conducive for responsible interpretation. The article consists of the following parts: introductory remarks on the value of reader-response theory for the interpretation of apocryphal texts; a short overview of reader-response criticism; a discussion and evaluation of three different aspects of Iser’s theory, namely ‘gaps’ in texts, ‘asymmetry’ between readers and texts and the concept of ‘the implied reader’. The findings of the investigation will be given in part five (Findings.

  6. Metformin in gestational diabetes mellitus: predictors of poor response.

    Gante, Inês; Melo, Luís; Dores, Jorge; Ruas, Luísa; Almeida, Maria do Céu


    Metformin can be regarded as a first-line treatment in gestational diabetes mellitus (GDM) due to its safety and effectiveness. However, a proportion of women do not achieve adequate glycemic control with metformin alone. We aim to identify predictors of this poor response to metformin. Retrospective multicentre cohort study of women with GDM who started metformin as first-line treatment. The assessed cohort was divided into a metformin group and metformin plus insulin group. Biometric and demographic characteristics, glycemic control data, obstetric, neonatal and postpartum outcomes were compared between groups and analysed in order to identify predictors of poor response to metformin. Data were analysed using STATA, version 13.1. Of the 388 women enrolled in the study, 135 (34.8%) required additional insulin therapy to achieve the glycemic targets. Higher age (aOR: 1.08 (1.03-1.13), P  = 0.003), higher pre-pregnancy body mass index (BMI) (1.06 (1.02-1.10), P  = 0.003) and earlier introduction of metformin (0.89 (0.85-0.94), P  metformin, insulin supplementation was not associated with poor neonatal outcomes. Higher age, higher pre-pregnancy BMI and earlier introduction of metformin could be used as predictors of poor response to metformin. © 2018 European Society of Endocrinology.

  7. Historical imagination, narrative learning and nursing practice: graduate nursing students' reader-responses to a nurse's storytelling from the past.

    Wood, Pamela J


    Storytelling and narrative are widely used in nurse education and the value of narrative-based curricula, such as those governed by narrative pedagogy, is well recognised. Storytelling stimulates students' imagination, a central feature of narrative learning. One form of story and imagination yet to be fully considered by educators is the historical story and historical imagination. The use of historical storytelling creates a temporal dissonance between the story and reader that stimulates readers' imagination and response, and enables them to gain rich insights which can be applied to the present. Reader-response theory can support educators when using narrative and storytelling. This article presents an analysis of graduate nursing students' reader-responses to a nurse's story from the past. This narrative learning group used their historical imagination in responding to the story and prompted and challenged each other in their interpretation and in translating their responses to their current nursing practice. The article discusses this analysis within the context of reader-response theory and its potential application to narrative-based learning in nurse education. Historical stories stimulate historical imagination and offer a different frame of reference for students' development of textual competence and for applying insights to the present. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. Poor Response to Periodontal Treatment May Predict Future Cardiovascular Disease.

    Holmlund, A; Lampa, E; Lind, L


    Periodontal disease has been associated with cardiovascular disease (CVD), but whether the response to the treatment of periodontal disease affects this association has not been investigated in any large prospective study. Periodontal data obtained at baseline and 1 y after treatment were available in 5,297 individuals with remaining teeth who were treated at a specialized clinic for periodontal disease. Poor response to treatment was defined as having >10% sites with probing pocket depth >4 mm deep and bleeding on probing at ≥20% of the sites 1 y after active treatment. Fatal/nonfatal incidence rate of CVD (composite end point of myocardial infarction, stroke, and heart failure) was obtained from the Swedish cause-of-death and hospital discharge registers. Poisson regression analysis was performed to analyze future risk of CVD. During a median follow-up of 16.8 y (89,719 person-years at risk), those individuals who did not respond well to treatment (13.8% of the sample) had an increased incidence of CVD ( n = 870) when compared with responders (23.6 vs. 15.3%, P 4 mm, and number of teeth, the incidence rate ratio for CVD among poor responders was 1.28 (95% CI, 1.07 to 1.53; P = 0.007) as opposed to good responders. The incidence rate ratio among poor responders increased to 1.39 (95% CI, 1.13 to 1.73; P = 0.002) for those with the most remaining teeth. Individuals who did not respond well to periodontal treatment had an increased risk for future CVD, indicating that successful periodontal treatment might influence progression of subclinical CVD.

  9. Excessive biologic response to IFNβ is associated with poor treatment response in patients with multiple sclerosis.

    Richard A Rudick

    Full Text Available BACKGROUND: Interferon-beta (IFNβ is used to inhibit disease activity in multiple sclerosis (MS, but its mechanisms of action are incompletely understood, individual treatment response varies, and biological markers predicting response to treatment have yet to be identified. METHODS: The relationship between the molecular response to IFNβ and treatment response was determined in 85 patients using a longitudinal design in which treatment effect was categorized by brain magnetic resonance imaging as good (n = 70 or poor response (n = 15. Molecular response was quantified using a customized cDNA macroarray assay for 166 IFN-regulated genes (IRGs. RESULTS: The molecular response to IFNβ differed significantly between patients in the pattern and number of regulated genes. The molecular response was strikingly stable for individuals for as long as 24 months, however, suggesting an individual 'IFN response fingerprint'. Unexpectedly, patients with poor response showed an exaggerated molecular response. IRG induction ratios demonstrated an exaggerated molecular response at both the first and 6-month IFNβ injections. CONCLUSION: MS patients exhibit individually unique but temporally stable biological responses to IFNβ. Poor treatment response is not explained by the duration of biological effects or the specific genes induced. Rather, individuals with poor treatment response have a generally exaggerated biological response to type 1 IFN injections. We hypothesize that the molecular response to type I IFN identifies a pathogenetically distinct subset of MS patients whose disease is driven in part by innate immunity. The findings suggest a strategy for biologically based, rational use of IFNβ for individual MS patients.

  10. Effects of Topic Familiarity and Training in Generative Learning Activities on Poor Readers' Comprehension of Comparison/Contrast Expository Text Structure: Transfer to Real-World Materials.

    Weisberg, Renee; Balajthy, Ernest

    A study investigated transfer effects of training below average high school readers in the use of graphic organizers and summary writing on their recognition of compare/contrast text structure. Subjects, 32 high school students with below-expectancy standardized test scores, were placed in two groups: an experimental group (five males and 11…

  11. Responses to Struggling, K-2 Readers and Writers: Early Literacy Intervention in Three Urban Schools

    Mooney, Kathleen C.


    An abundance of research on early literacy intervention indicates that struggling, K-2 readers and writers can be effectively supported through the receipt of intervention services in school; however, research in the area has not yet addressed study of the unique, contextualized design and implementation of early literacy intervention in different…

  12. Rhetoric and Etiological Beliefs About Sexuality: Reader Responses to Cynthia Nixon's New York Times Interview.

    Jowett, Adam; Barker, Sophie


    In 2012, the U.S. actress Cynthia Nixon was quoted in the New York Times Magazine as having stated that "for me, it [being gay] is a choice. I understand that for many people it's not, but for me it's a choice, and you don't get to define my gayness for me." The interview attracted international media attention and public criticism by lesbian and gay activists. This article suggests a rhetorical approach to understanding etiological beliefs and provides a discursive analysis of 198 online comments by readers of Pink News, a gay news Web site that reported on Nixon's controversial interview. This article explores common arguments used in readers' comments about Nixon and examines the rhetorical construction of sexuality. The analysis examines three themes within the data. First, biological essentialism was treated by many readers as common knowledge; second, readers suggested that only bisexuals have "choice"; and, third, it was suggested by both Nixon's critics and her supporters that counterarguments colluded with homophobia. The article suggests that there is an ideological dilemma whereby both "born-this-way" and "choice" arguments can be understood as colluding with anti-gay prejudice.

  13. Reader survey



    Many, thanks to the hundreds of people who took the time to reply to the CERN Courier readership survey questionnaire published in our May issue. Bringing out a monthly journal is a lonely business. Issue after issue goes out, and the only response is when there's an occasional factual error. Send out a readership survey and a faint echo comes back. Most striking was the sheer enthusiasm of the replies. Despite the current erosion of support in the US (see page 2), subatomic physics has significant world-wide box-office appeal. Most important was to find out who our readers are. 61% of the replies came from Europe, 21% from the USA, 14% from elsewhere, (including the former Soviet Union), and 4% from inside CERN. Not surprisingly, the main audience (37%) is in the high energy physics sector. Then comes teaching (31%), followed closely by accelerators operations and design (12%) and industry (11%). Apart from detailed breakdowns of readership and feedback on the journal's content and style, the replies revealed several major features. Firstly, the CERN Courier is widely read and appreciated. There are a lot of people outside the immediate research field who want to keep broadly up to date with the latest developments in high energy physics and related fields, without getting too involved in details. It was gratifying to receive replies from far-flung places (Nepal, Indonesia,....), and learn how much distant readers appreciate getting such regular information. 'It helps us feel part of the world scene,' was a typical such reply, from Australia. Despite jet airplanes, fax and electronic mail, our planet is still big.

  14. Reader survey



    Many, thanks to the hundreds of people who took the time to reply to the CERN Courier readership survey questionnaire published in our May issue. Bringing out a monthly journal is a lonely business. Issue after issue goes out, and the only response is when there's an occasional factual error. Send out a readership survey and a faint echo comes back. Most striking was the sheer enthusiasm of the replies. Despite the current erosion of support in the US (see page 2), subatomic physics has significant world-wide box-office appeal. Most important was to find out who our readers are. 61% of the replies came from Europe, 21% from the USA, 14% from elsewhere, (including the former Soviet Union), and 4% from inside CERN. Not surprisingly, the main audience (37%) is in the high energy physics sector. Then comes teaching (31%), followed closely by accelerators operations and design (12%) and industry (11%). Apart from detailed breakdowns of readership and feedback on the journal's content and style, the replies revealed several major features. Firstly, the CERN Courier is widely read and appreciated. There are a lot of people outside the immediate research field who want to keep broadly up to date with the latest developments in high energy physics and related fields, without getting too involved in details. It was gratifying to receive replies from far-flung places (Nepal, Indonesia,....), and learn how much distant readers appreciate getting such regular information. 'It helps us feel part of the world scene,' was a typical such reply, from Australia. Despite jet airplanes, fax and electronic mail, our planet is still big

  15. Reader-Response Theory: A Path Towards Wolfgang Iser (La teoría de la recepción: una ruta hacia Wolfgang Iser

    Alejandra Giangiulio Lobo


    Full Text Available Se estudia la teoría de la recepción a partir de diferentes autores y críticos literarios, para caracterizar los distintos tipos de lectores, según cada aproximación y los procesos de lectura y creación de significado. El ensayo se centra en el enfoque fenomenológico de Wolfgang Iser sobre la recepción del lector, la generación de significado y los tipos de lectores. Reader-response theory is studied from the perspective of different authors and literary critics to characterize the different types of readers, according to each approach, the reading process and the creation of meaning. The essay centers on Wolfgang Iser’s phenomenological approach to reader response, creation of meaning and types of readers.





    I Wayan Suka Yasa


    Full Text Available The object of this research is the text of Geguritan Sucita having total versesof 1,877. The problem observed is that the structure, esthetic rule applied andsource of text transformation into GS as religion literature. The main objective ofthis research is to answer the three problems concerned. In addition, it has theobjective to preserve and develop geguritan literature. The benefit can be as oneof sources of knowledge in literary science, especially concerning geguritanliterature; as the consideration in making policy related to religion and Balineseculture; and also as reading material, especially for readers of geguritan literature.The theory applied in reviewing the three problems is structural, semiotic,intertext, rasa (mode and literature reception. The data source obtained byconducting literature study, observation and interview. The data is the analyzedfrom literature and religion point of view. The research novelties are as follows :GS is gita puja of Ida Ketut Jlantik (1905-1961 which is offered to GodAlmighty. As worshipped song, GS is sekar. The materials are quoted fromclassical works of prior Hindu which is then arranged in accordance with idealismof writers kawi-wiku by considering rule of k?vya.GS is established using Balinese language Kepara enriched withvocabularies of Old Javanese so it has Hindu esthetic. Formal structure of GS isestablished according to geguritan : padalingsa matrix. The text consists of 1,877rhythm, 11 rhyme and 57 melodies. Sinom rhythm as the idol one to lead otherrhythm in order to s?nta rasa. Verses of GS can be grouped into two parts: 4rhythm manggala and 1,873 narrative rhythm. Totally, formal structure of GSfulfills alamkara principle. the text has melody and euphony religious melody.Narrative structure GS is established following norm of tattwa purarbh?wa‘reborn cycle’, in addition it is the leader of rhythm as well as function as epilog.In term of contemplative reading level bhakti yoga

  18. Poorly differentiated neuroendocrine carcinoma of the pancreas responsive to combination therapy with gemcitabine and S-1.

    Yamamoto, Mitsuyoshi; Miyagawa, Koichiro; Hiura, Masaaki; Taguchi, Masashi; Kihara, Yasuyuki; Abe, Shintaro; Shimajiri, Shohei; Harada, Masaru


    Poorly differentiated neuroendocrine carcinoma is a very rare malignancy, but it is characterized by agressive histological features and a poor clinical prognosis. We report a 42-year-old man who had poorly differentiated neuroendocrine carcinoma of the pancreas with multiple liver metastases. We administrated combined chemotherapy with S-1 and gemcitabine. This treatment was efficacious and well tolerated, and then this patient obtained objective partial response for 7 months and survived for 13 months after the diagnosis. This case suggests that S-1 and gemcitabine combination produce beneficial responses for patients with this disease.

  19. Association of poor metabolizers of cytochrome P450 2C19 with head and neck cancer and poor treatment response

    Yadav, Sunishtha S.; Ruwali, Munindra; Shah, Parag P. [Developmental Toxicology Division, Indian Institute of Toxicology Research, CSIR P.O. Box 80, M.G. Marg, Lucknow 226001 (India); Mathur, Neeraj [Environmental Epidemiology Division, Indian Institute of Toxicology Research, CSIR P.O. Box 80, M.G. Marg, Lucknow 226001 (India); Singh, Ram L. [Department of Biochemistry, Dr. R.M.L. Awadh University, Faizabad 224 001, U.P. (India); Pant, Mohan C. [Department of Radiotherapy, C.S.M. Medical University, Shahmina Road, Lucknow 226 001 (India); Parmar, Devendra [Developmental Toxicology Division, Indian Institute of Toxicology Research, CSIR P.O. Box 80, M.G. Marg, Lucknow 226001 (India)], E-mail:


    A case-control study consisting of 300 patients and an equal number of healthy controls was carried out to investigate the association of polymorphism in cytochrome P450 2C19 (CYP2C19), which results in poor and extensive metabolizers (PMs and EMs) genotypes, with squamous cell carcinoma of head and neck (HNSCC) and treatment response in patients receiving combination of chemo-radiotherapy. A higher frequency of CYP2C19*2 variants was observed in the cases resulting in significantly higher risk to HNSCC (Ad OR 3.36, 95% CI 1.94-5.82, p-value < 0.05). The PM genotype of CYP2C19*3 was also found to be slightly increased in the cases, though the increase in risk was not significant when analyzed by multivariate logistic regression model. Tobacco chewing amongst the cases resulted in almost 13-fold increase in the risk with CYP2C19*2 (OR: 12.39) and 3-fold with CYP2C19*3 genotype (OR: 2.90) when compared to the tobacco chewers amongst the controls. Likewise, cigarette smoking in the cases increased the risk approximately 9-fold and 3-fold with CYP2C19*2 (OR: 8.93) and CYP2C19*3 (OR: 2.18) genotypes respectively when compared to smokers amongst the controls. Similar increase in risk was associated with alcohol use amongst the cases carrying variant genotypes of CYP2C19*2 (OR: 7.75) or CYP2C19*3 (OR: 2.60), demonstrating the importance of gene-environment interaction in modifying susceptibility to HNSCC. Interestingly, patients with PMs of CYP2C19 (CYP2C19*2 and CYP2C19*3) exhibited little response to the respective chemotherapy than the patients carrying wild-type genotype demonstrating that functional enzyme deficiencies due to polymorphism in CYPs may not only be important in modifying the susceptibility to HNSCC but also in determining chemotherapeutic response.

  20. Policy Reader


    This policy reader comprises: Correspondence; Memorandum of Understanding between the US Department of Transportation and the US Department of Energy for the Transportation of Radioactive Materials under the Nuclear Waste Policy Act; Internal Guidelines for Interactions with Communities and Local Governments; Statement by Ben C. Rusche before the Committee on Interior and Insular Affairs, Subcommittee on Energy and the Environment, US House of Representatives, September 13, 1985; Speech presented by Ben C. Rusche before the ANS/CNS/AESJ/ENS Topical Meeting, Pasco, Washington, September 24, 1985 - ''Status of the United States' High-Level Nuclear Waste Disposal Program''; and ''DOE Seeks Comments on Nuclear Transportation Planning,'' DOE News, September 30, 1985

  1. An Analysis of Differential Response Patterns on the Peabody Picture Vocabulary Test-IIIB in Struggling Adult Readers and Third-Grade Children

    Pae, Hye K.; Greenberg, Daphne; Williams, Rihana S.


    This study examines the Peabody Picture Vocabulary Test-IIIB (PPVT-IIIB) performance of 130 adults identified as struggling readers, in comparison to 175 third-grade children. Response patterns to the items on the PPVT-IIIB by these two groups were investigated, focusing on items, semantic categories, and lexical features, including word length,…

  2. Assessing Learned Helplessness in Poor Readers.

    Winograd, Peter; Niquette, Garland


    Feelings of helplessness can impact on learning to read. This research review illustrates problems in assessing learned helplessness, including instrumentation inadequacies, lack of comprehensive causal schemes, context specificity, etc. Observations of and discussions with the child are recommended in the assessment process. Guidelines for…

  3. Differences in autonomic physiological responses between good and poor inductive reasoners.

    Melis, C; van Boxtel, A


    We investigated individual- and task-related differences in autonomic physiological responses induced by time limited figural and verbal inductive reasoning tasks. In a group of 52 participants, the percentage of correctly responded task items was evaluated together with nine different autonomic physiological response measures and respiration rate (RR). Weighted multidimensional scaling analyses of the physiological responses revealed three underlying dimensions, primarily characterized by RR, parasympathetic, and sympathetic activity. RR and sympathetic activity appeared to be relatively more important response dimensions for poor reasoners, whereas parasympathetic responsivity was relatively more important for good reasoners. These results suggest that poor reasoners showed higher levels of cognitive processing intensity than good reasoners. Furthermore, for the good reasoners, the dimension of sympathetic activity was relatively more important during the figural than during the verbal reasoning task, which was explained in terms of hemispheric lateralization in autonomic function.

  4. The response of common building construction technologies to the urban poor and their environment

    Wekesa, BW


    Full Text Available of the technologies are not responsive in the regional context. That is, the technologies cannot provide a good quality dwelling unit and at the same time address the socio-economic needs of the urban poor while minimising the negative impact on the environment....

  5. Doctors' stress responses and poor communication performance in simulated bad-news consultations.

    Brown, Rhonda; Dunn, Stewart; Byrnes, Karen; Morris, Richard; Heinrich, Paul; Shaw, Joanne


    No studies have previously evaluated factors associated with high stress levels and poor communication performance in breaking bad news (BBN) consultations. This study determined factors that were most strongly related to doctors' stress responses and poor communication performance during a simulated BBN task. In 2007, the authors recruited 24 doctors comprising 12 novices (i.e., interns/residents with 1-3 years' experience) and 12 experts (i.e., registrars, medical/radiation oncologists, or cancer surgeons, with more than 4 years' experience). Doctors participated in simulated BBN consultations and a number of control tasks. Five-minute-epoch heart rate (HR), HR variability, and communication performance were assessed in all participants. Subjects also completed a short questionnaire asking about their prior experience BBN, perceived stress, psychological distress (i.e., anxiety, depression), fatigue, and burnout. High stress responses were related to inexperience with BBN, fatigue, and giving bad versus good news. Poor communication performance in the consultation was related to high burnout and fatigue scores. These results suggest that BBN was a stressful experience for doctors even in a simulated encounter, especially for those who were inexperienced and/or fatigued. Poor communication performance was related to burnout and fatigue, but not inexperience with BBN. These results likely indicate that burnout and fatigue contributed to stress and poor work performance in some doctors during the simulated BBN task.

  6. Oosorption in response to poor food: complexity in the trade-off between reproduction and survival

    Moore, Patricia J; Attisano, Alfredo


    Plasticity in reproductive physiology is one avenue by which environmental signals, such as poor quality food, can be coordinated with adaptive responses. Insects have the ability to resorb oocytes that are not oviposited. Oosorption is proposed to be an adaptive mechanism to optimize fitness in hostile environments, recouping resources that might otherwise be lost, and reinvesting them into future reproductive potential. We tested the hypothesis that oosorption is an evolved mechanism by which females can reallocate resources from current reproductive effort to survival and future reproduction, when conditions for reproduction are poor, by examining the reproductive physiology and life-history outcome under poor quality food in populations of the milkweed bug (Oncopeltus fasciatus) that have adapted to live on sunflower seed. Females fed a diet of pumpkin seeds, known to be a poor host food, had higher levels of ovarian apoptosis (oosorption), lower reproductive output, but no reduction in life span under poor nutrition, as predicted under the oosorption hypothesis. However, the schedule of reproduction was surprising given the “wait to reproduce” assumption of oosorption as early fecundity was unaffected. PMID:22393481

  7. Inter-Reader Reliability of Early FDG-PET/CT Response Assessment Using the Deauville Scale after 2 Cycles of Intensive Chemotherapy (OEPA) in Hodgkin's Lymphoma.

    Kluge, Regine


    The five point Deauville (D) scale is widely used to assess interim PET metabolic response to chemotherapy in Hodgkin lymphoma (HL) patients. An International Validation Study reported good concordance among reviewers in ABVD treated advanced stage HL patients for the binary discrimination between score D1,2,3 and score D4,5. Inter-reader reliability of the whole scale is not well characterised.

  8. Dissociation predicts poor response to Dialectial Behavioral Therapy in female patients with Borderline Personality Disorder.

    Kleindienst, Nikolaus; Limberger, Matthias F; Ebner-Priemer, Ulrich W; Keibel-Mauchnik, Jana; Dyer, Anne; Berger, Mathias; Schmahl, Christian; Bohus, Martin


    A substantial proportion of Borderline Personality Disorder (BPD) patients respond by a marked decrease of psychopathology when treated with Dialectical Behavioral Therapy (DBT). To further enhance the rate of DBT-response, it is useful to identify characteristics related to unsatisfactory response. As DBT relies on emotional learning, we explored whether dissociation-which is known to interfere with learning- predicts poor response to DBT. Fifty-seven Borderline Personality Disorder (BPD) patients (DSM-IV) were prospectively observed during a three-month inpatient DBT program. Pre-post improvements in general psychopathology (SCL-90-R) were predicted from baseline scores of the Dissociative Experiences Scale (DES) by regression models accounting for baseline psychopathology. High DES-scores were related to poor pre-post improvement (β = -0.017 ± 0.006, p = 0.008). The data yielded no evidence that some facets of dissociation are more important in predicting DBT-response than others. The results suggest that dissociation in borderline-patients should be closely monitored and targeted during DBT. At this stage, research on treatment of dissociation (e.g., specific skills training) is warranted.

  9. Reader-Response Theory: A Path Towards Wolfgang Iser (La teoría de la recepción: una ruta hacia Wolfgang Iser)

    Giangiulio Lobo, Alejandra


    Se estudia la teoría de la recepción a partir de diferentes autores y críticos literarios, para caracterizar los distintos tipos de lectores, según cada aproximación y los procesos de lectura y creación de significado. El ensayo se centra en el enfoque fenomenológico de Wolfgang Iser sobre la recepción del lector, la generación de significado y los tipos de lectores.Reader-response theory is studied from the perspective of different authors and literary critics to characterize the different t...

  10. What Can Readers Read after Graded Readers?

    McQuillan, Jeff


    Nation (2014) concluded that most of the vocabulary one needs to read challenging texts in English can be acquired incidentally through voluminous reading. This study examines possible texts that second language (L2) readers can use to move from controlled-vocabulary materials such as graded readers, which go up through approximately the…

  11. Insulin resistance is associated with a poor response to intravenous thrombolysis in acute ischemic stroke.

    Calleja, Ana I; García-Bermejo, Pablo; Cortijo, Elisa; Bustamante, Rosa; Rojo Martínez, Esther; González Sarmiento, Enrique; Fernández-Herranz, Rosa; Arenillas, Juan F


    Insulin resistance (IR) may not only increase stroke risk, but could also contribute to aggravate stroke prognosis. Mainly through a derangement in endogenous fibrinolysis, IR could affect the response to intravenous thrombolysis, currently the only therapy proved to be efficacious for acute ischemic stroke. We hypothesized that high IR is associated with more persistent arterial occlusions and poorer long-term outcome after stroke thrombolysis. We performed a prospective, observational, longitudinal study in consecutive acute ischemic stroke patients presenting with middle cerebral artery (MCA) occlusion who received intravenous thrombolysis. Patients with acute hyperglycemia (≥155 mg/dL) receiving insulin were excluded. IR was determined during admission by the homeostatic model assessment index (HOMA-IR). Poor long-term outcome, as defined by a day 90 modified Rankin scale score ≥ 3, was considered the primary outcome variable. Transcranial Duplex-assessed resistance to MCA recanalization and symptomatic hemorrhagic transformation were considered secondary end points. A total of 109 thrombolysed MCA ischemic stroke patients were included (43.1% women, mean age 71 years). The HOMA-IR was higher in the group of patients with poor outcome (P = 0.02). The probability of good outcome decreased gradually with increasing HOMA-IR tertiles (80.6%, 1st tertile; 71.4%, 2nd tertile; and 55.3%, upper tertile). A HOMA-IR in the upper tertile was independently associated with poor outcome when compared with the lower tertile (odds ratio [OR] 8.54 [95% CI 1.67-43.55]; P = 0.01) and was associated with more persistent MCA occlusions (OR 8.2 [1.23-54.44]; P = 0.029). High IR may be associated with more persistent arterial occlusions and worse long-term outcome after acute ischemic stroke thrombolysis.

  12. Local Failure in Parameningeal Rhabdomyosarcoma Correlates With Poor Response to Induction Chemotherapy

    Ladra, Matthew M. [Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Mandeville, Henry C. [The Royal Marsden Hospital, London (United Kingdom); Niemierko, Andrzej; Padera, Timothy P.; Friedmann, Alison M.; MacDonald, Shannon M.; Ebb, David; Chen, Yen-Lin; Tarbell, Nancy J. [Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Yock, Torunn I., E-mail: [Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)


    Background: Local control remains a challenge in pediatric parameningeal rhabdomyosarcoma (PM-RMS), and survival after local failure (LF) is poor. Identifying patients with a high risk of LF is of great interest to clinicians. In this study, we examined whether tumor response to induction chemotherapy (CT) could predict LF in embryonal PM-RMS. Methods: We identified 24 patients with embryonal PM-RMS, age 2 to 18 years, with complete magnetic resonance imaging and gross residual disease after surgical resection. All patients received proton radiation therapy (RT), median dose 50.4 Gy{sub RBE} (50.4-55.8 Gy{sub RBE}). Tumor size was measured before initial CT and before RT. Results: With a median follow-up time of 4.1 years for survivors, LF was seen in 9 patients (37.5%). The median time from the initiation of CT to the start of RT was 4.8 weeks. Patients with LF had a similar initial (pre-CT) tumor volume compared with patients with local controlled (LC) (54 cm{sup 3} vs 43 cm{sup 3}, P=.9) but a greater median volume before RT (pre-RT) (40 cm{sup 3} vs 7 cm{sup 3}, P=.009) and a smaller median relative percent volume reduction (RPVR) in tumor size (0.4% vs 78%, P<.001). Older age (P=.05), larger pre-RT tumor volume (P=.03), and smaller RPVR (P=.003) were significantly associated with actuarial LF on univariate Cox analysis. Conclusions: Poor response to induction CT appears to be associated with an increased risk of LF in pediatric embryonal PM-RMS.

  13. Novel processing of Barkhausen noise signal for assessment of residual stress in surface ground components exhibiting poor magnetic response

    Vashista, M.; Paul, S.


    The Barkhausen Noise Analysis (BNA) technique has been utilised to assess surface integrity of steels. But the BNA technique is not very successful in evaluating surface integrity of ground steels that exhibit poor micro-magnetic response. A new approach has been proposed for the processing of BN signal and two newly proposed parameters, namely 'count' and 'event', have been shown to correlate linearly with the residual stress upon grinding, with judicious choice of user defined 'threshold', even when the micro-magnetic response of the work material is poor. In the present study, residual stress induced upon conventional plunge surface grinding of hardened bearing steel has been investigated along with unhardened bearing steel for benchmarking. Moreover, similar correlation has been established, when primarily compressive stress is induced upon high speed grinding using cBN wheel with moderately deep cut suppressing the micro-magnetic response from the ground medium carbon steel as the work material. - Highlights: → The problem of work materials exhibiting poor BN response and poor Barkhausen Noise response is identified. → A novel signal processing strategy is introduced to address the issue of poor micro-magnetic response of some ferromagnetic material. → Potential of newly introduced BN parameters has been studied. → These two BN parameters exhibited linear correlation with residual stress for work material with poor micro-magnetic response.



  15. Thermoluminescence dosimeter reader

    Robertson, M.E.A.; Marshall, J.; Brabants, J.A.P.; Davies, M.E.


    An electric circuit arrangement is described including a photomultiplier tube and a high voltage source therefor also includes a feedback loop from the output of the tube to the high voltage source, and loop providing automatic gain stabilization for the tube. The arrangement is used in a dosimeter reader to provide sensitivity correction for the reader each time the reader is to be used

  16. ULK1: a promising biomarker in predicting poor prognosis and therapeutic response in human nasopharygeal carcinoma.

    Miao Yun

    Full Text Available Plenty of studies have established that dysregulation of autophagy plays an essential role in cancer progression. The autophagy-related proteins have been reported to be closely associated with human cancer patients' prognosis. We explored the expression dynamics and prognostic value of autophagy-related protein ULK1 by immunochemistry (IHC method in two independent cohorts of nasopharygeal carcinoma (NPC cases. The X-tile program was applied to determine the optimal cut-off value in the training cohort. This derived cutoff value was then subjected to analysis the association of ULK1 expression with patients' clinical characteristics and survival outcome in the validation cohort and overall cases. High ULK1 expression was closely associated with aggressive clinical feature of NPC patients. Furthermore, high expression of ULK1 was observed more frequently in therapeutic resistant group than that in therapeutic effective group. Our univariate and multivariate analysis also showed that higher ULK1 expression predicted inferior disease-specific survival (DSS (P<0.05. Consequently, a new clinicopathologic prognostic model with 3 poor prognostic factors (ie, ULK1 expression, overall clinical stage and therapeutic response could significantly stratify risk (low, intermediate and high for DSS in NPC patients (P<0.001. These findings provide evidence that, the examination of ULK1 expression by IHC method, could serve as an effective additional tool for predicting therapeutic response and patients' survival outcome in NPC patients.

  17. Dynamic hyperinflation is associated with a poor cardiovascular response to exercise in COPD patients

    Tzani Panagiota


    Full Text Available Abstract Background Pulmonary hyperinflation has the potential for significant adverse effects on cardiovascular function in COPD. The aim of this study was to investigate the relationship between dynamic hyperinflation and cardiovascular response to maximal exercise in COPD patients. Methods We studied 48 patients (16F; age 68 yrs ± 8; BMI 26 ± 4 with COPD. All patients performed spirometry, plethysmography, lung diffusion capacity for carbon monoxide (TLco measurement, and symptom-limited cardiopulmonary exercise test (CPET. The end-expiratory lung volume (EELV was evaluated during the CPET. Cardiovascular response was assessed by change during exercise in oxygen pulse (ΔO2Pulse and double product, i.e. the product of systolic blood pressure and heart rate (DP reserve, and by the oxygen uptake efficiency slope (OUES, i.e. the relation between oxygen uptake and ventilation. Results Patients with a peak exercise EELV (%TLC ≥ 75% had a significantly lower resting FEV1/VC, FEF50/FIF50 ratio and IC/TLC ratio, when compared to patients with a peak exercise EELV (%TLC 2Pulse (r = - 0.476, p = 0.001, OUES (r = - 0.452, p = 0.001 and DP reserve (r = - 0.425, p = 0.004. Furthermore, according to the ROC curve method, ΔO2Pulse and DP reserve cut-off points which maximized sensitivity and specificity, with respect to a EELV (% TLC value ≥ 75% as a threshold value, were ≤ 5.5 mL/bpm (0.640 sensitivity and 0.696 specificity and ≤ 10,000 Hg · bpm (0.720 sensitivity and 0.783 specificity, respectively. Conclusion The present study shows that COPD patients with dynamic hyperinflation have a poor cardiovascular response to exercise. This finding supports the view that in COPD patients, dynamic hyperinflation may affect exercise performance not only by affecting ventilation, but also cardiac function.

  18. Nasal nitric oxide is associated with exhaled NO, bronchial responsiveness and poor asthma control.

    Krantz, C; Janson, C; Borres, M P; Nordvall, L; Alving, K; Malinovschi, A


    The fraction of exhaled nitric oxide (FeNO) is an established marker of airway inflammation in asthma. Nasal nitric oxide (nNO) has initially been regarded as a promising marker of inflammation of nasal mucosa. However, due to its dual origins, paranasal sinuses and nasal mucosa, the clinical use of nNO is controversial. There is an inflammatory link between inflammation in the upper and lower airways within the united airways' paradigm, but the study of the clinical value of nNO in asthma has been limited. The objective of this study is to analyse nNO in asthmatics and its relationship to FeNO, bronchial hyperresponsiveness, allergic sensitization and asthma control. A total of 371 children and young adults from an asthma cohort were included in this study, which performed measurements of nNO (through aspiration at 5 mL s(-1)), FeNO, bronchial responsiveness to methacholine, blood eosinophil count (B-Eos) and IgE sensitization. The asthma control test (ACT) and a questionnaire regarding medical treatment, symptoms of asthma, rhinitis and chronic rhinosinusitis were completed by all subjects. An association was found between higher nNO levels and increased bronchial responsiveness (p < 0.001), FeNO (p < 0.001) and B-Eos (p = 0.002). Sensitization to furry animals related to higher levels of nNO (p < 0.001). Subjects with poorly controlled asthma (ACT < 15) had lower levels of nNO than subjects with a higher ACT score (619 ± 278 ppb, versus 807 ± 274 ppb, p = 0.002). Loss of smell showed the strongest association with lower nNO levels among the upper airway symptoms recorded. In patients with asthma, nNO was positively correlated with exhaled NO, bronchial responsiveness and asthma control. This study suggests clinical utility of nNO in subjects with asthma, but in order to get better understanding of the nNO determinants, simultaneous mapping of upper airway comorbidities by clinical examination is appropriate.

  19. [Exogenous luteinizing hormone for assisted reproduction techniques in poor response patients].

    Spremović-Radjenović, Svetlana; Gudović, Aleksandra; Lazović, Gordana


    Two gonadotrophins, two cell theory refers to necessity of both gonadotrophin activities for theca and granulose cells steroidogenesis of dominant follicle. The aim of this study was to determine the influence of recombinant LH in women qualified as poor responders in the first assisted reproduction procedure (IVF), on fertility results, expressed as percentage of clinical pregnancies. The study included 12 women, 35 years and older who were their own controls. The next trial of IVF was with the same dose of recombinant FSH and GnRH agonist, and with the same, long protocol. Recombinant LH was added in the dose of 75 IU from the 2nd to 7th day of the cycle, and 150 IU from the 8th day of the cycle to the aspiration of oocytes. Within the two different protocols: there was no significant difference between LH concentration in 8th and 12th day of cycle; there was no significant difference between E2 concentration on day 2nd and day 8th; there was a significant difference between E2 concentrations on day 12th; endometrial thickness was not significantly different on the day of aspiration, neither was the number of follicles and embryos. In the two patients, clinical pregnancy was detected (pregnancy rate 17%), and they delivered in term. So, a statistically significant difference between the two protocols was in the rate of clinical pregnancies. The patients with low response to a long protocol in IVF procedures had significantly better results according to the clinical pregnancy rate when the recombinant LH was added to recombinant FSH in the stimulation protocol.

  20. Poor response to antidepressants predicts new suicidal ideas and behavior in depressed outpatients.

    Courtet, Philippe; Jaussent, Isabelle; Lopez-Castroman, Jorge; Gorwood, Philip


    Only a few studies have investigated the factors associated with suicidal behavior after antidepressant treatment onset in adults. We examined the specific predictors of de novo suicidal ideas or attempts among depressed patients in the community, including subjects potentially at risk of suicidal behaviors, who initiated a new antidepressant treatment. A large set of GPs and psychiatrists throughout France followed-up, for 6 weeks, 4357 outpatients for whom an antidepressant drug was prescribed. Dimensions related with antidepressant-induced suicidal events, such as depression, anxiety or hopelessness, were assessed longitudinally using univariate and multivariate approaches among subjects with treatment-emergent suicide ideation or attempts. New suicidal ideas were observed in 9% of patients with no suicidal ideation at baseline (n=81), while suicidal attempts were reported for 1.7% of the sample during the 6-week observation period (n=75). The onset of suicidal ideas and attempts was associated with the initial features of the patients (baseline level of anxiety, past history of suicide attempts and alcohol misuse) and the non-improvement of depression. Worsening of depressive symptoms during the follow-up increased the onset of new suicidal ideas (OR=5.67, pideas or attempts, the link between antidepressants and suicide risk might be more adequately explained by a poor response to antidepressant treatment rather than by a direct trigger-effect. This naturalistic study is limited by the use of non-structured diagnoses and self-report outcomes. Copyright © 2014 Elsevier B.V. and ECNP. All rights reserved.

  1. Readers and Texts in the Primary Years. Rethinking Reading.

    Martin, Tony; Leather, Bob

    Exploring the responses of a variety of readers from three-year-old Dominic sharing a picture book with his father to adults reading a poem by Ted Hughes, this book examines the ways in which various readers respond to different texts. The aim of the book is to develop an awareness of the issues involved in readers' responses for primary teachers.…

  2. Cyber Literature: A Reader – Writer Interactivity

    Fathu Rahman


    Full Text Available Cyber Literature is a term known since the coming of the internet which brings a convenience, changing habit and world view. This study is a survey-based on respondents’ opinion about the existence of cyber literature on social media; of its benefit and impact to the reader. This study limits to the poems on Facebook group. The reason is simple; it favors the short form. For the study of a reader-writer interactivity in cyber literature is more likely on poetry. The approach is reader response literary theory with focus on the reader-writer interactivity on Facebook. This research aimed at uncovering the motivation of readers to response the uploaded text, the reasons why they love it and what its advantages. The results showed that cyber literature is successfully to introduce a new literary genre as well as to raise motivation and creativity of authors to make use the internet space.

  3. Texts and Readers.

    Iser, Wolfgang


    Notes that, since fictional discourse need not reflect prevailing systems of meaning and norms or values, readers gain detachment from their own presuppositions; by constituting and formulating text-sense, readers are constituting and formulating their own cognition and becoming aware of the operations for doing so. (FL)

  4. Public responses to proposals for a tax on sugar-sweetened beverages: A thematic analysis of online reader comments posted on major UK news websites.

    Molly Thomas-Meyer

    Full Text Available Regular consumption of sugar sweetened beverages (SSBs is associated with weight gain, type 2 diabetes, and dental caries. The UK will introduce a levy on the manufacturers of SSBs in 2018. Details will be negotiated over the next two years. How the UK public views SSB taxes is likely to be an important determinant of the content and success of the final policy. We aimed to capture the views, ideas and concerns of commenters on major UK news websites on SSB taxes.We conducted a qualitative analysis of reader comments to online news coverage of one proposal for an SSB tax in the UK. 1645 comments on four articles were included. Three underpinning themes influenced support or opposition to the tax: the balance between individual responsibility and autonomy, and population need; mistrust of the intention of the proposed tax and those promoting it; and variations in the perceived complexity of unhealthy diets and obesity associated with variations in what are considered appropriate interventions. Arguments under each theme were used to justify both support and opposition in different cases.As the final form of the UK SSB tax is negotiated, effort should be made to address the concerns we identified. Our results suggest these efforts could usefully focus on emphasising the social and environmental determinants of diet and obesity, reinforcing the benefits of the tax to the NHS, and pitching the tax as playing into a variety of different conceptualisations of obesity.

  5. Postmodern theories about readers in electronic environment

    Ivanka Kuić


    Full Text Available Introductory part of the paper discusses theories about readers in the last decades of the 20th century. In particular, two big theoretical schools are discussed: aesthetic reception theory and reader-response-criticism movement. Readers are a subject of very different scientific disciplines: literature theory, sociology, anthropology, book history and library science. The idea that a reader is an essential subject for future life of a literary work is common to all theorists. By constructing the theory about a reader, theorists have thought about the reader who uses the conventions of printed text. The issue whether these concepts correspond to electronic surroundings is discussed. Characteristics of the hypertext are emphasized as a new paradigm, and also the issue weather readers enjoys in hypertextual fiction. In conclusion, paper expands the virtual dimension of Isers's theory about interaction between the text and the reader, and also Fish's concept of “interpretative community” which may be constituted on the Internet as a flexible virtual community.


    Dewi Candraningrum Soekirno


    Full Text Available Abstract: The spread of the so-called ‘indispensable language’ for the immersion of English in the global world has mesmerized its victims in the classrooms through the operation of curriculum, material, and teaching methodology. Since the perspective of the traditional/structuralism school could not provide enough ‘reader involvement’, reader-response is one of the alternatives that support teaching against the grain. It provides the

  7. Differences in autonomic physiological responses between good and poor inductive reasoners

    Melis, C.J.; van Boxtel, A.


    We investigated individual- and task-related differences in autonomic physiological responses induced by time limited figural and verbal inductive reasoning tasks. In a group of 52 participants, the percentage of correctly responded task items was evaluated together with nine different autonomic

  8. Response to comments on "Productivity is a poor predictor of plant species richness"

    Grace, James B.; Adler, Peter B.; Seabloom, Eric W.; Borer, Elizabeth T.; Hillebrand, Helmut; Hautier, Yann; Hector, Andy; Harpole, W. Stanley; O'Halloran, Lydia R.; Anderson, T. Michael; Bakker, Jonathan D.; Brown, Cynthia S.; Buckley, Yvonne M.; Collins, Scott L.; Cottingham, Kathryn L.; Crawley, Michael J.; Damschen, Ellen Ingman; Davies, Kendi F.; DeCrappeo, Nicole M.; Fay, Philip A.; Firn, Jennifer; Gruner, Daniel S.; Hagenah, Nicole; Jin, Virginia L.; Kirkman, Kevin P.; Knops, Johannes M.H.; La Pierre, Kimberly J.; Lambrinos, John G.; Melbourne, Brett A.; Mitchell, Charles E.; Moore, Joslin L.; Morgan, John W.; Orrock, John L.; Prover, Suzanne M.; Stevens, Carly J.; Wragg, Peter D.; Yang, Louie H.


    Pan et al. claim that our results actually support a strong linear positive relationship between productivity and richness, whereas Fridley et al. contend that the data support a strong humped relationship. These responses illustrate how preoccupation with bivariate patterns distracts from a deeper understanding of the multivariate mechanisms that control these important ecosystem properties.

  9. Businessmen v. Investigators: who is responsible for the Poor Russian Investment Climate?

    Dmitry Gololobov


    Full Text Available This article aims to examine the extent to which Russian investigations into economic and financial crimes are influenced by such factors as systemic problems with Russian gatekeepers, the absence of a formal corporate whistle-blowing mechanism and the continuous abuse of the law by the Russian business community. The traditional critical approach to the quality and effectiveness of Russian economic and financial investigations does not produce positive results and needs to be reformulated by considering the opinions of entrepreneurs. The author considers that forcing Russian entrepreneurs, regardless of the size of their business, to comply with Russian laws and regulations may be a more efficient way to develop the business environment than attempting to gradually improve the Russian judicial system. It is also hardly possible to expect the Russian investigatory bodies to investigate what are effectively complex economic and financial crimes in the almost complete absence of a developed whistle-blowing culture. Such a culture has greatly contributed to the success of widely-publicised corporate and financial investigations in the United States and Europe. The poor development of the culture of Russian gatekeepers and the corresponding regulatory environment is one more significant factor that permanently undermines the effectiveness of economic investigations and damages the investment climate.

  10. Rectal Cancer: Mucinous Carcinoma on Magnetic Resonance Imaging Indicates Poor Response to Neoadjuvant Chemoradiation

    Oberholzer, Katja; Menig, Matthias; Kreft, Andreas; Schneider, Astrid; Junginger, Theodor; Heintz, Achim; Kreitner, Karl-Friedrich; Hötker, Andreas M.; Hansen, Torsten; Düber, Christoph; Schmidberger, Heinz


    Purpose: To assess response of locally advanced rectal carcinoma to chemoradiation with regard to mucinous status and local tumor invasion found at pretherapeutic magnetic resonance imaging (MRI). Methods and Materials: A total of 88 patients were included in this prospective study of patients with advanced mrT3 and mrT4 carcinomas. Carcinomas were categorized by MRI as mucinous (mucin proportion >50% within the tumor volume), and as nonmucinous. Patients received neoadjuvant chemoradiation consisting of 50.4 Gy (1.8 Gy/fraction) and 5-fluorouracil on Days 1 to 5 and Days 29 to 33. Therapy response was assessed by comparing pretherapeutic MRI with histopathology of surgical specimens (minimum distance between outer tumor edge and circumferential resection margin = CRM, T, and N category). Results: A mucinous carcinoma was found in 21 of 88 patients. Pretherapeutic mrCRM was 0 mm (median) in the mucinous and nonmucinous group. Of the 88 patients, 83 underwent surgery with tumor resection. The ypCRM (mm) at histopathology was significantly lower in mucinous carcinomas than in nonmucinous carcinomas (p ≤ 0.001). Positive resection margins (ypCRM ≤ 1 mm) were found more frequently in mucinous carcinomas than in nonmucinous ones (p ≤ 0.001). Treatment had less effect on local tumor stage in mucinous carcinomas than in nonmucinous carcinomas (for T downsizing, p = 0.012; for N downstaging, p = 0.007). Disease progression was observed only in patients with mucinous carcinomas (n = 5). Conclusion: Mucinous status at pretherapeutic MRI was associated with a noticeably worse response to chemoradiation and should be assessed by MRI in addition to local tumor staging to estimate response to treatment before it is initiated.


    José Marcos Rosendo de Souza


    Full Text Available Research on formation of readers has raised some discussions and change of atitudes, to the development of full readers. But, the methodologies that strive for proficiency of Deaf readers there are scarse. We intend to discuss in this article the formation of a reader Deaf through from an interventional research, with cognitive approach. The reader formation of Deaf will be possible with appropriate method to their peculiarities.

  12. Poor response inhibition: at the nexus between substance abuse and attention deficit/hyperactivity disorder.

    Groman, Stephanie M; James, Alex S; Jentsch, J David


    The co-morbidity between attention deficit hyperactivity disorder (ADHD) and substance abuse and dependence disorders may have multiple causes and consequences. In this review, we will describe neurobehavioral, genetic and animal model studies that support the notion that a common, genetically determined failure of response inhibition function is an endophenotype for both disorders. Through an impairment in the ability to cognitively control pre-potent behaviors, subjects can exhibit a collection of ADHD-like traits (impulsivity and hyperactivity), as well as susceptibility for the initiation of drug taking and its ultimate progression to an inflexible, uncontrollable form. At the neural level, dysfunction within circuitry that includes the ventrolateral frontal and cingulate cortices, as well as in associated basal ganglia zones, contributes to a common pattern of behavioral impairment, explaining aspects of co-morbidity. Animal models of substance abuse/dependence and ADHD that exhibit deficits in response inhibition have substantiated the role of this endophenotype in both disorders and their co-morbidity and should provide a testing ground for interventions targeting it. New directions for research that will further explore this hypothesis and begin to reveal the underlying biological mechanisms will be proposed.

  13. Our Readers Write ...

    IAS Admin

    This concerns the article 'Ashoke Sen and S-duality'. The article omits an important fact: there is absolutely no experimental evidence for string theory. Without this information, readers may think they are reading about established facts, not speculation. A string theorist, Witten, was awarded a Fields Medal, which shows that ...

  14. Bytes, Books and Readers

    Rasmussen, Krista Stinne Greve


    In diesem Beitrag werden Ergebnisse aus der Dissertation der Autorin Bytes, Books, and Readers. A Historical Analysis of the Transition from Printed to Digital Scholarly Editions Focusing on ‘The Writings of Søren Kierkegaard’ (2015) vorgestellt. Dabei wird dem Wechselverhältnis zwischen der...

  15. Growing Young Gifted Readers

    Wood, Patricia F.


    There is great pressure on parents to teach children to read as early as possible. In reality, precocious (early advanced) readers seem to almost master the skill on their own, without the assistance of highly touted, commercially available programs. The 18-month-old toddler who names the letters on alphabet blocks; or the 26-month-old who can…

  16. Fast and slow readers of the Hebrew language show divergence in brain response ∼200 ms post stimulus: an ERP study.

    Sebastian Peter Korinth

    Full Text Available Higher N170 amplitudes to words and to faces were recently reported for faster readers of German. Since the shallow German orthography allows phonological recoding of single letters, the reported speed advantages might have their origin in especially well-developed visual processing skills of faster readers. In contrast to German, adult readers of Hebrew are forced to process letter chunks up to whole words. This dependence on more complex visual processing might have created ceiling effects for this skill. Therefore, the current study examined whether also in the deep Hebrew orthography visual processing skills as reflected by N170 amplitudes explain reading speed differences. Forty university students, native speakers of Hebrew without reading impairments, accomplished a lexical decision task (i.e., deciding whether a visually presented stimulus represents a real or a pseudo word and a face decision task (i.e., deciding whether a face was presented complete or with missing facial features while their electroencephalogram was recorded from 64 scalp positions. In both tasks stronger event related potentials (ERPs were observed for faster readers in time windows at about 200 ms. Unlike in previous studies, ERP waveforms in relevant time windows did not correspond to N170 scalp topographies. The results support the notion of visual processing ability as an orthography independent marker of reading proficiency, which advances our understanding about regular and impaired reading development.

  17. Pushover, Response Spectrum and Time History Analyses of Safe Rooms in a Poor Performance Masonry Building

    Mazloom, M.


    The idea of safe room has been developed for decreasing the earthquake casualties in masonry buildings. The information obtained from the previous ground motions occurring in seismic zones expresses the lack of enough safety of these buildings against earthquakes. For this reason, an attempt has been made to create some safe areas inside the existing masonry buildings, which are called safe rooms. The practical method for making these safe areas is to install some prefabricated steel frames in some parts of the existing structure. These frames do not carry any service loads before an earthquake. However, if a devastating earthquake happens and the load bearing walls of the building are destroyed, some parts of the floors, which are in the safe areas, will fall on the roof of the installed frames and the occupants who have sheltered there will survive. This paper presents the performance of these frames located in a destroying three storey masonry building with favorable conclusions. In fact, the experimental pushover diagram of the safe room located at the ground-floor level of this building is compared with the analytical results and it is concluded that pushover analysis is a good method for seismic performance evaluation of safe rooms. For time history analysis the 1940 El Centro, the 2003 Bam, and the 1990 Manjil earthquake records with the maximum peak accelerations of 0.35g were utilized. Also the design spectrum of Iranian Standard No. 2800-05 for the ground kind 2 is used for response spectrum analysis. The results of time history, response spectrum and pushover analyses show that the strength and displacement capacity of the steel frames are adequate to accommodate the distortions generated by seismic loads and aftershocks properly

  18. Influenza A virus infection engenders a poor antibody response against the ectodomain of matrix protein 2

    Wunner William


    Full Text Available Abstract Background Matrix protein 2 (M2 is an integral tetrameric membrane protein of influenza A virus (IAV. Its ectodomain (M2e shows remarkably little diversity amongst human IAV strains. As M2e-specific antibodies (Abs have been shown to reduce the severity of infection in animals, M2e is being studied for its capability of providing protection against a broad range of IAV strains. Presently, there is little information about the concentration of M2e-specific Abs in humans. Two previous studies made use of ELISA and Western blot against M2e peptides and recombinant M2 protein as immunosorbents, respectively, and reported Ab titers to be low or undetectable. An important caveat is that these assays may not have detected all Abs capable of binding to native tetrameric M2e. Therefore, we developed an assay likely to detect all M2e tetramer-specific Abs. Results We generated a HeLa cell line that expressed full length tetrameric M2 (HeLa-M2 or empty vector (HeLa-C10 under the control of the tetracycline response element. These cell lines were then used in parallel as immunosorbents in ELISA. The assay was standardized and M2e-specific Ab titers quantified by means of purified murine or chimeric (mouse variable regions, human constant regions M2e-specific Abs in the analysis of mouse and human sera, respectively. We found that the cell-based ELISA was substantially more effective than immobilized M2e peptide in detecting M2e-specific Abs in sera of mice that had recovered from repetitive IAV infections. Still, titers remained low ( Conclusion The results provide convincing evidence that M2e-specific Ab-mediated protection is currently lacking or suboptimal in humans.

  19. Elevated ratio of MMP2/MMP9 activity is associated with poor response to chemotherapy in osteosarcoma

    Kunz, Pierre; Sähr, Heiner; Lehner, Burkhard; Fischer, Christian; Seebach, Elisabeth; Fellenberg, Jörg


    = 0.006). In contrast to mRNA or protein levels MMP and TIMP activities showed significant differences between the analyzed good and poor responder groups. A shift from MMP9 to predominant MMP2 activity is associated with poor response to chemotherapy suggesting that the ratio of MMP2/MMP9 activity might be a valuable and easily accessible marker to predict the response to chemotherapy in osteosarcoma

  20. Crash course in readers' advisory

    Orr, Cynthia


    One of the key services librarians provide is helping readers find books they'll enjoy. This ""crash course"" will furnish you with the basic, practical information you need to excel at readers' advisory (RA) for adults and teens.

  1. Sleep disruption is related to poor response inhibition in individuals with obsessive-compulsive and repetitive negative thought symptoms.

    Nota, Jacob A; Schubert, Jessica R; Coles, Meredith E


    Obsessive-compulsive (OC) symptoms and repetitive negative thinking (RNT) are associated with poor inhibitory control. Sleep disruptions may partially mediate these relations and/or act as a "second hit" to individuals with OC symptoms and RNT. Models including habitual (past month) hours slept and bedtimes were tested. We employed a go/no-go task that allowed us to examine the relation between sleep and inhibition with various task contingencies. Sixty-seven unselected individuals were recruited from the participant pool at a public university. Bias-corrected bootstrap estimates did not show that sleep disruption mediated the relation between OC symptoms and response inhibition nor the relation between RNT and response inhibition. Multiple linear regression analyses found significant interactions between hours slept and OC symptom severity and between RNT and hours slept to predict poor response inhibition. Hours slept significantly negatively predicted commission errors when OC symptoms and RNT levels were relatively heightened but not when OC symptoms and RNT levels were relatively low. These effects were present in blocks where task contingencies were designed to shape a no-go bias. No significant relations were found with habitual bedtimes. The cross-sectional study design precludes testing the temporal precedence of symptoms in the "second hit" model. The unselected sample also limits generalization to clinical samples. These findings support a "second hit" model of interaction between sleep disruption and perseverative thoughts and behaviors. Further research on the mechanisms of the relation between sleep disruption and perseverative thought symptoms (OC and RNT) is warranted. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Novel biomarkers in primary breast core biopsies to predict poor response to neoadjuvant chemotherapy and appearance of metastases.

    Novell, Anna; Morales, Serafin; Valls, Joan; Panadés, Maria José; Salud, Antonieta; Iglesias, Edelmiro; Vilardell, Felip; Matias-Guiu, Xavier; Llombart-Cussac, Antonio


    Drug resistance has been one of the major obstacles limiting the success of cancer chemotherapy. In two thirds of breast cancer patients, large (>1cm) residual tumors are present after neoadjuvant chemotherapy (NCT). The residual tumor and involved nodes have been indicators of relapse and survival very important in breast cancer. The goal of this preliminary study was to assess the predictive significance of a panel of molecular biomarkers, related with the response to treatment or drug resistance to NCT, as determined on the diagnostic tumor. The expression of 22 proteins was examined using immunohistochemistry in tissue microarrays (TMA) from 115 patients of stage II-III breast cancer, treated with NCT. Among studied proteins, there are some that are anti-apoptotic, pro-proliferative, cancer stem cell markers and the Vitamin D Receptor. Other proteins are involved in the identification of molecular subtype, cell cycle regulation or DNA repair. Next, a predictive signature of poor response was generated from independent markers of predictive value. Tumors that expressed four or five conditions (biomarkers of chemoresistance with a determinated cutoff) were associated with a 9-fold increase in the chances of these patients of having a poor response to NCT. Additionally, we also found a worse prognostic signature, generated from independent markers of prognostic value. Tumors which expressed two or three conditions of worst prognostic, were associated with a 6-fold reduction in Distant Disease Free Survival. In conclusion, finding biomarkers of chemoresitance (ypTNM II-III) and metastases can become a stepping stone for future studies that will need to be assessed in a bigger scale.

  3. Lexical Decision and Oral Reading by Poor and Normal Readers

    Bon, W.H.J. van; Tooren, P.H.; Eekelen, K.W.J.M. van


    The primary goal of this study was to compare a paper-and-pencil version of the lexical decision task, which can be administered groupwise, with reading aloud a differently ordered list of the same words and pseudowords. Participants were first and second graders (“normal readers”) and students from

  4. Mathematics skills in good readers with hydrocephalus.

    Barnes, Marcia A; Pengelly, Sarah; Dennis, Maureen; Wilkinson, Margaret; Rogers, Tracey; Faulkner, Heather


    Children with hydrocephalus have poor math skills. We investigated the nature of their arithmetic computation errors by comparing written subtraction errors in good readers with hydrocephalus, typically developing good readers of the same age, and younger children matched for math level to the children with hydrocephalus. Children with hydrocephalus made more procedural errors (although not more fact retrieval or visual-spatial errors) than age-matched controls; they made the same number of procedural errors as younger, math-level matched children. We also investigated a broad range of math abilities, and found that children with hydrocephalus performed more poorly than age-matched controls on tests of geometry and applied math skills such as estimation and problem solving. Computation deficits in children with hydrocephalus reflect delayed development of procedural knowledge. Problems in specific math domains such as geometry and applied math, were associated with deficits in constituent cognitive skills such as visual spatial competence, memory, and general knowledge.

  5. Poorly Responsive Celiac Disease

    ... Close Celiac Disease Understanding Celiac Disease What is Celiac Disease? Symptoms Screening and Diagnosis Treatment and Follow-Up Dermatitis ... Schuppan D, Kelly CP. Etiologies and predictors of diagnosis in nonresponsive celiac disease. Clin Gastroenterol Hepatol 2007; 5 : 445–50. Finding ...

  6. Cognitive Development in Early Readers.

    Briggs, Chari; Elkind, David

    Some studies of early readers are discussed. It is pointed out that study of early readers has relevance for practical and theoretical issues in psychology and education. Of interest in this document are the following questions: (1) Are there any special talents or traits distinguishing early from non-early readers? (2) Do children who read early…

  7. [Survey among readers of the Tijdschrift voor Psychiatrie].

    Brandt-Dominicus, J C; van Harten, P N


    The editorial board has defined the objectives of this journal as follows: to provide its readers with refreshing information, to report the results of scientific research and to build bridges between research and everyday practice. To find out what readers want and whether they support the board's objectives, and to use this information in planning the contents of future issues of the journal. All readers were invited to complete a questionnaire either on paper or via the website. Questionnaires were completed by 255 readers (response rate 5.7%). The average rating on a 5-point Likert scale was 3.8. Thematic issues and issues devoted to book reviews were given a high rating. There seems to be a demandfor evidence-based medicine, the inclusion of scientific results reported in other journals and practice-based articles. No significant differences were found between the views expressed by readers who had previously submitted an article for publication and those who had not, nor between Flemish readers and Dutch readers. The website was not visited very often. The Tijdschrift voor Psychiatrie is greatly appreciated by its readers. They are largely in agreement with the objectives formulated by the editorial board. Thematic issues are highly rated and many subjects are mentioned by the readers for future issues. The low response to the survey can affect its representativity. The editorial board will take readers' wishes into consideration when selecting material for future issues of the journal.

  8. Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy

    Sadikovic, Bekim; Thorner, Paul; Chilton-MacNeill, Susan; Martin, Jeff W; Cervigne, Nilva K; Squire, Jeremy; Zielenska, Maria


    Human osteosarcoma is the most common pediatric bone tumor. There is limited understanding of the molecular mechanisms underlying osteosarcoma oncogenesis, and a lack of good diagnostic as well as prognostic clinical markers for this disease. Recent discoveries have highlighted a potential role of a number of genes including: RECQL4, DOCK5, SPP1, RUNX2, RB1, CDKN1A, P53, IBSP, LSAMP, MYC, TNFRSF1B, BMP2, HISTH2BE, FOS, CCNB1, and CDC5L. Our objective was to assess relative expression levels of these 16 genes as potential biomarkers of osteosarcoma oncogenesis and chemotherapy response in human tumors. We performed quantitative expression analysis in a panel of 22 human osteosarcoma tumors with differential response to chemotherapy, and 5 normal human osteoblasts. RECQL4, SPP1, RUNX2, and IBSP were significantly overexpressed, and DOCK5, CDKN1A, RB1, P53, and LSAMP showed significant loss of expression relative to normal osteoblasts. In addition to being overexpressed in osteosarcoma tumor samples relative to normal osteoblasts, RUNX2 was the only gene of the 16 to show significant overexpression in tumors that had a poor response to chemotherapy relative to good responders. These data underscore the loss of tumor suppressive pathways and activation of specific oncogenic mechanisms associated with osteosarcoma oncogenesis, while drawing attention to the role of RUNX2 expression as a potential biomarker of chemotherapy failure in osteosarcoma

  9. Fibroblastic growth factor receptor 1 amplification in osteosarcoma is associated with poor response to neo-adjuvant chemotherapy

    Fernanda Amary, M; Ye, Hongtao; Berisha, Fitim; Khatri, Bhavisha; Forbes, Georgina; Lehovsky, Katie; Frezza, Anna M; Behjati, Sam; Tarpey, Patrick; Pillay, Nischalan; Campbell, Peter J; Tirabosco, Roberto; Presneau, Nadège; Strauss, Sandra J; Flanagan, Adrienne M


    Osteosarcoma, the most common primary bone sarcoma, is a genetically complex disease with no widely accepted biomarker to allow stratification of patients for treatment. After a recent report of one osteosarcoma cell line and one tumor exhibiting fibroblastic growth factor receptor 1 (FGFR1) gene amplification, the aim of this work was to assess the frequency of FGFR1 amplification in a larger cohort of osteosarcoma and to determine if this biomarker could be used for stratification of patients for treatment. About 352 osteosarcoma samples from 288 patients were analyzed for FGFR1 amplification by interphase fluorescence in situ hybridization. FGFR1 amplification was detected in 18.5% of patients whose tumors revealed a poor response to chemotherapy, and no patients whose tumors responded well to therapy harbored this genetic alteration. FGFR1 amplification is present disproportionately in the rarer histological variants of osteosarcoma. This study provides a rationale for inclusion of patients with osteosarcoma in clinical trials using FGFR kinase inhibitors

  10. Dose reader CD-02

    Jakowiuk, A.; Kaluska, I.; Machaj, B.


    Dose Reader CD-02 is designed for measurement of dose from a long narrow band of dosimetric foil used for check up and control of electron beam dose during sterilization of materials and products on conveyor belt. Irradiated foil after processing (heating) is inserted into foil driving (moving) system and when the foil is moved across focused light beam the absorbed dose is measured and displayed at the same time at computer monitor (in form of a diagram). The absorbed dose is measured on the principle of light attenuation at selected light wavelength (foil absorbance is measured). (author)

  11. Chipless RFID reader architecture

    Karmakar, Nemai Chandra; Kalansuriya, Prasanna


    In the era of information communication technology (ICT), radio frequency identification (RFID) has been going through tremendous development. RFID technology has the potential of replacing barcodes due to its large information carrying capacity, flexibility in operations, and applications. The deployment of RFID has been hindered by its cost. However, with the advent of low powered ICs, energy scavenging techniques, and low-cost chipless tags, RFID technology has achieved significant development. This book addresses the new reader architecture, presents fundamentals of chipless RFID systems,

  12. Reception theory and the Christian reader: A preliminary perspective

    A. L. Comhrink


    Full Text Available In recent years there has been a significant shift in emphasis from text- centred criticism in literature to reader-centred criticism. This new field of criticism, called Reception Theory or Reader Response Criticism, denies the immutable nature of the "text” and regards as its object of study the work of literature that is created through the co-constituent creative and interpre­tive acts o f both writer and reader.

  13. Poor CD4 response despite viral suppression is associated with increased non-AIDS related mortality among HIV patients and their parents

    Helleberg, Marie; Kronborg, Gitte; Larsen, Carsten S


    association between poor CD4 response and increased risk of cardiovascular disease and cancer (IRR 1.6 (95%CI 0.8-3.2) and 1.6 (95%CI 0.6-4.8)). CONCLUSIONS:: poor CD4 increase after HAART is associated with adverse prognosis even in absence of severe immunosuppression. CD4 response in HIV patients......INTRODUCTION:: poor CD4 response to antiretroviral treatment (HAART) is associated with increased mortality. We analyzed the impact of CD4 increase on non-AIDS related morbidity and on mortality in HIV patients and their parents. METHODS:: mortality rates were estimated among 1,758 virally...... is associated with mortality among their parents, thus poor CD4 response may be caused by genetic factors, which might also affect morbidity and mortality in the HIV negative population....

  14. E-Book Readers in Higher Education

    Arthur N. Olsen


    Full Text Available This article reports on a research project at the University of Agder that has studied the use of e-readers as a tool for academic study. E-readers (Kindle DX and iPad were loaded with texts from required reading lists in five courses with 94 participating students. Initially, 87 students responded to the invitation to participate in a survey, but eventually 13 of these submissions had to be removed, as the degree of completion was not sufficient. The final response rate achieved was 79%. Students were in general positive to the use of e-readers but still show a preference for print on paper as the best medium for serious academic study. When reading books, 54% preferred print, 28% a combination of print and e-reader, and finally only 11% were satisfied solely using an e-reader. The iPad scored significantly better than the Kindle DX on tasks that required active interaction with the texts such as highlighting and note taking.

  15. Presence of Systemic Inflammatory Response Syndrome Predicts a Poor Clinical Outcome in Dogs with a Primary Hepatitis.

    Scott Kilpatrick

    Full Text Available Primary hepatopathies are a common cause of morbidity and mortality in dogs. The underlying aetiology of most cases of canine hepatitis is unknown. Consequently, treatments are typically palliative and it is difficult to provide accurate prognostic information to owners. In human hepatology there is accumulating data which indicates that the presence of systemic inflammatory response syndrome (SIRS is a common and debilitating event in patients with liver diseases. For example, the presence of SIRS has been linked to the development of complications such as hepatic encephalopathy (HE and is associated with a poor clinical outcome in humans with liver diseases. In contrast, the relationship between SIRS and clinical outcome in dogs with a primary hepatitis is unknown. Seventy dogs with histologically confirmed primary hepatitis were enrolled into the study. Additional clinical and clinicopathological information including respiratory rate, heart rate, temperature, white blood cell count, sodium, potassium, sex, presence of ascites, HE score, alanine aminotransferase (ALT, alkaline phosphatase (ALP, bilirubin and red blood cell concentration were available in all cases. The median survival of dogs with a SIRS score of 0 or 1 (SIRS low was 231 days compared to a median survival of 7 days for dogs with a SIRS score of 2, 3 or 4 (SIRS high (p<0.001. A Cox proportional hazard model, which included all other co-variables, revealed that a SIRS high score was an independent predictor of a poor clinical outcome. The effect of modulating inflammation on treatment outcomes in dogs with a primary hepatitis is deserving of further study.

  16. Philadelphia chromosome-positive adult acute leukemia with monosomy of chromosome number seven: a subgroup with poor response to therapy.

    Maddox, A M; Keating, M J; Trujillo, J; Cork, A; Youness, E; Ahearn, M J; McCredie, K B; Freireich, E J


    Thirty-four adult patients were seen at the University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, Texas between 1969 and 1980 with acute leukemia (AL) and a deleted G-group chromosome that was shown by Giemsa banding to be a Philadelphia (Ph1) chromosome t(9;22) in 21 patients. Fourteen had the Ph1 chromosome as the sole abnormality, 12 had the Ph1 chromosome and loss of one chromosome of the C-group (identified by Giemsa banding analysis as number 7 in eight patients), while eight had the Ph1 chromosome and other changes. These three groups were similar in sex, age distribution and hematologic parameters. The median age of 40 was lower than usually seen in AL. The distribution of the morphologic subtypes was similar to that seen at this institution, with 50% being acute myeloblastic, 12% acute myelomonocytic, 20% lymphoblastic and 18% acute undifferentiated. The complete remission rate with chemotherapy was low: 25% in the Ph1 +/- 7, 50% in the Ph1 +/other group and 43% in the Ph1 +/other group. Median survival time was 8 months for the Ph1 +/- 7 group, 5.5 months for the Ph1 +/other group and 9.0 months for the Ph1 +/alone group. These patients with Ph1 + AL had higher white blood cell counts, increased extramedullary disease and poorer responses to therapy than usual for patients with AL. The deletion of chromosome 7 and the acquisition of the Ph1 chromosome identifies a group of patients with characteristics similar to all the patients with Ph1 + AL but a poor response to therapy and short remission duration.

  17. GSTT1 copy number gain and ZNF overexpression are predictors of poor response to imatinib in gastrointestinal stromal tumors.

    Eui Jin Lee

    Full Text Available Oncogenic mutations in gastrointestinal stromal tumors (GISTs predict prognosis and therapeutic responses to imatinib. In wild-type GISTs, the tumor-initiating events are still unknown, and wild-type GISTs are resistant to imatinib therapy. We performed an association study between copy number alterations (CNAs identified from array CGH and gene expression analyses results for four wild-type GISTs and an imatinib-resistant PDGFRA D842V mutant GIST, and compared the results to those obtained from 27 GISTs with KIT mutations. All wild-type GISTs had multiple CNAs, and CNAs in 1p and 22q that harbor the SDHB and GSTT1 genes, respectively, correlated well with expression levels of these genes. mRNA expression levels of all SDH gene subunits were significantly lower (P≤0.041, whereas mRNA expression levels of VEGF (P=0.025, IGF1R (P=0.026, and ZNFs (P<0.05 were significantly higher in GISTs with wild-type/PDGFRA D842V mutations than GISTs with KIT mutations. qRT-PCR validation of the GSTT1 results in this cohort and 11 additional malignant GISTs showed a significant increase in the frequency of GSTT1 CN gain and increased mRNA expression of GSTT1 in wild-type/PDGFRA D842V GISTs than KIT-mutant GISTs (P=0.033. Surprisingly, all four malignant GISTs with KIT exon 11 deletion mutations with primary resistance to imatinib had an increased GSTT1 CN and mRNA expression level of GSTT1. Increased mRNA expression of GSTT1 and ZNF could be predictors of a poor response to imatinib. Our integrative approach reveals that for patients with wild-type (or imatinib-resistant GISTs, attempts to target VEGFRs and IGF1R may be reasonable options.

  18. Report Card on Basal Readers.

    Goodman, Kenneth S.; And Others

    This report examines the nature of the modern basal reader, its economics, and use. First, the report provides a history showing how the confluence of business principles, positivistic science, and behavioral psychology led to the transformation of reading textbooks into basal readers. Next, the report examines objectives and subjective factors…

  19. The Routledge Applied Linguistics Reader

    Wei, Li, Ed.


    "The Routledge Applied Linguistics Reader" is an essential collection of readings for students of Applied Linguistics. Divided into five sections: Language Teaching and Learning, Second Language Acquisition, Applied Linguistics, Identity and Power and Language Use in Professional Contexts, the "Reader" takes a broad…

  20. Metacognition and Reading: Comparing Three Forms of Metacognition in Normally Developing Readers and Readers with Dyslexia.

    Furnes, Bjarte; Norman, Elisabeth


    Metacognition refers to 'cognition about cognition' and includes metacognitive knowledge, strategies and experiences (Efklides, 2008; Flavell, 1979). Research on reading has shown that better readers demonstrate more metacognitive knowledge than poor readers (Baker & Beall, 2009), and that reading ability improves through strategy instruction (Gersten, Fuchs, Williams, & Baker, 2001). The current study is the first to specifically compare the three forms of metacognition in dyslexic (N = 22) versus normally developing readers (N = 22). Participants read two factual texts, with learning outcome measured by a memory task. Metacognitive knowledge and skills were assessed by self-report. Metacognitive experiences were measured by predictions of performance and judgments of learning. Individuals with dyslexia showed insight into their reading problems, but less general knowledge of how to approach text reading. They more often reported lack of available reading strategies, but groups did not differ in the use of deep and surface strategies. Learning outcome and mean ratings of predictions of performance and judgments of learning were lower in dyslexic readers, but not the accuracy with which metacognitive experiences predicted learning. Overall, the results indicate that dyslexic reading and spelling problems are not generally associated with lower levels of metacognitive knowledge, metacognitive strategies or sensitivity to metacognitive experiences in reading situations. 2015 The Authors. Dyslexia Published by John Wiley & Sons Ltd.

  1. Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass

    Dirksen, C; Jørgensen, N B; Bojsen-Møller, K N


    Objective:To identify factors contributing to the variation in weight loss after Roux-en-Y gastric bypass (RYGB).Design:Cross-sectional study of patients with good (excess body mass index lost (EBL) >60%) and poor weight loss response (EBL 12 months after RYGB and a lean control group matched for...

  2. Trickling Down: Are Rural and Rural Poor Family Incomes Responsive to Regional Economic Growth? Institute for Research on Poverty, Discussion Papers No. 210-74.

    Weber, Bruce A.

    The past decade has seen a number of studies of how the poverty incidence (the percentage of families below the poverty line) of certain demographic groups changes in response to economic growth. The question of whether regional economic growth trickles down to rural and rural poor families was examined by statistically estimating the relationship…

  3. Does Feeling Come First? How Poetry Can Help Readers Broaden Their Understanding of Metacognition

    Eva-Wood, Amy L.


    Assuming that readers' emotional responses can enhance readers' metacognitive experiences and inform literary analysis, this study of 11th-grade poetry readers features instruction that models both cognitive and affective reading processes. The author: (1) Presents a case for more explicit attention to emotion in language arts classrooms; (2)…

  4. Sharing International Responsibility for the Protection of Poor Migrants? An Analysis of Extraterritorial Socio-Economic Human Rights Law

    Hesselman, Marlies


    This paper analyzes the possible legal bases for or the existence of extraterritorial socio-economic human rights obligations on the part of wealthier European ‘Destination Countries’ vis-à-vis poor migrants. In particular, the paper considers whether obligations of international cooperation and

  5. The rnf168 paralog rnf169 defines a new class of ubiquitylated histone reader involved in the response to dna damage

    Kitevski-Leblanc, Julianne; Fradet-Turcotte, Amélie; Kukic, Predrag; Wilson, Marcus D.; Portella, Guillem; Yuwen, Tairan; Panier, Stephanie; Duan, Shili; Canny, Marella D.; Van Ingen, Hugo; Arrowsmith, Cheryl H.; Rubinstein, John L.; Vendruscolo, Michele; Durocher, Daniel; Kay, Lewis E


    Site-specific histone ubiquitylation plays a central role in orchestrating the response to DNA double-strand breaks (DSBs). DSBs elicit a cascade of events controlled by the ubiquitin ligase RNF168, which promotes the accumulation of repair factors such as 53BP1 and BRCA1 on the chromatin flanking

  6. Resource-poor settings: response, recovery, and research: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement.

    Geiling, James; Burkle, Frederick M; West, T Eoin; Uyeki, Timothy M; Amundson, Dennis; Dominguez-Cherit, Guillermo; Gomersall, Charles D; Lim, Matthew L; Luyckx, Valerie; Sarani, Babak; Christian, Michael D; Devereaux, Asha V; Dichter, Jeffrey R; Kissoon, Niranjan


    Planning for mass critical care in resource-poor and constrained settings has been largely ignored, despite large, densely crowded populations who are prone to suffer disproportionately from natural disasters. As a result, disaster response has been suboptimal and in many instances hampered by lack of planning, education and training, information, and communication. The Resource-Poor Settings panel developed five key question domains; defining the term resource poor and using the traditional phases of the disaster cycle (mitigation/preparedness/response/recovery). Literature searches were conducted to identify evidence to answer the key questions in these areas. Given a lack of data on which to develop evidence-based recommendations, expert-opinion suggestions were developed, and consensus was achieved using a modified Delphi process. The five key questions were as follows: definition, capacity building and mitigation, what resources can we bring to bear to assist/surge, response, and reconstitution and recovery of host nation critical care capabilities. Addressing these led the panel to offer 33 suggestions. Because of the large number of suggestions, the results have been separated into two sections: part I, Infrastructure/Capacity in the accompanying article, and part II, Response/Recovery/Research in this article. A lack of rudimentary ICU resources and capacity to enhance services plagues resource-poor or constrained settings. Capacity building therefore entails preventative strategies and strengthening of primary health services. Assistance from other countries and organizations is often needed to mount a surge response. Moreover, the disengagement of these responding groups and host country recovery require active planning. Future improvements in all phases require active research activities.

  7. Silenced B-Cell Receptor Response To Autoantigen In A Poor-Prognostic Subset Of Chronic Lymphocytic Leukemia

    Bergh, Ann-Charlotte; Evaldsson, Chamilly; Pedersen, Lone Bredo


    Chronic lymphocytic leukemia B cells express auto/xeno antigen-reactive antibodies that bind to self-epitopes and resemble natural IgM antibodies in their repertoire. One of the antigenic structures recognized is oxidation-induced malonedialdehyde that is present on low-density lipoprotein......-cell receptor unresponsiveness to cognate self-antigen on its own in poor-prognostic subset #1 chronic lymphocytic leukemia, indicating that these cells proliferate by other mechanisms that may override B-cell receptor silencing brought about in a context of self-tolerance/anergy. These novel findings have...

  8. Neutralizing antibodies explain the poor clinical response to Interferon beta in a small proportion of patients with Multiple Sclerosis: a retrospective study

    Cefaro Luca


    Full Text Available Abstract Background Neutralizing antibodies (NAbs against Interferon beta (IFNβ are reported to be associated with poor clinical response to therapy in multiple sclerosis (MS patients. We aimed to quantify the contribution of NAbs to the sub-optimal response of IFNβ treatment. Methods We studied the prevalence of NAbs in MS patients grouped according to their clinical response to IFNβ during the treatment period. Patients were classified as: group A, developing ≥ 1 relapse after the first 6 months of therapy; group B, exhibiting confirmed disability progression after the first 6 months of therapy, with or without superimposed relapses; group C, presenting a stable disease course during therapy. A cytopathic effect assay tested the presence of NAbs in a cohort of ambulatory MS patients treated with one of the available IFNβ formulations for at least one year. NAbs positivity was defined as NAbs titre ≥ 20 TRU. Results Seventeen patients (12.1% were NAbs positive. NAbs positivity correlated with poorer clinical response (p Conclusion The majority of patients with poor clinical response are NAbs negative suggesting that NAbs explains only partially the sub-optimal response to IFNβ.

  9. A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole

    Garcia-Casado, Zaida; Cervera-Deval, Jose; Campos, Josefina; Albaladejo, Carlos Vazquez; Llombart-Bosch, Antonio; Guillem, Vicente; Lopez-Guerrero, Jose A; Guerrero-Zotano, Angel; Llombart-Cussac, Antonio; Calatrava, Ana; Fernandez-Serra, Antonio; Ruiz-Simon, Amparo; Gavila, Joaquin; Climent, Miguel A; Almenar, Sergio


    Aromatase (CYP19A1) regulates estrogen biosynthesis. Polymorphisms in CYP19A1 have been related to the pathogenesis of breast cancer (BC). Inhibition of aromatase with letrozole constitutes the best option for treating estrogen-dependent BC in postmenopausal women. We evaluate a series of polymorphisms of CYP19A1 and their effect on response to neoadjuvant letrozole in early BC. We analyzed 95 consecutive postmenopausal women with stage II-III ER/PgR [+] BC treated with neoadjuvant letrozole. Response to treatment was measured by radiology at 4 th month by World Health Organization (WHO) criteria. Three polymorphisms of CYP19A1, one in exon 7 (rs700519) and two in the 3'-UTR region (rs10046 and rs4646) were evaluated on DNA obtained from peripheral blood. Thirty-five women (36.8%) achieved a radiological response to letrozole. The histopathological and immunohistochemical parameters, including hormonal receptor status, were not associated with the response to letrozole. Only the genetic variants (AC/AA) of the rs4646 polymorphism were associated with poor response to letrozole (p = 0.03). Eighteen patients (18.9%) reported a progression of the disease. Those patients carrying the genetic variants (AC/AA) of rs4646 presented a lower progression-free survival than the patients homozygous for the reference variant (p = 0.0686). This effect was especially significant in the group of elderly patients not operated after letrozole induction (p = 0.009). Our study reveals that the rs4646 polymorphism identifies a subgroup of stage II-III ER/PgR [+] BC patients with poor response to neoadjuvant letrozole and poor prognosis. Testing for the rs4646 polymorphism could be a useful tool in order to orientate the treatment in elderly BC patients

  10. Triage for Struggling Adolescent Readers

    Diamond, Linda J.


    To improve achievement for struggling readers in particular, secondary schools must design programs and curricula to address students' lack of background knowledge, delayed English language development, and limited success in reading. In this article, the author presents a systems approach that offers intensive care for the most at-risk students…

  11. Readers' Knowledge of Popular Genre

    Dixon, Peter; Bortolussi, Marisa


    This research examined readers' knowledge of popular genres. Participants wrote short essays on fantasy, science fiction, or romance. The similarities among the essays were measured using latent semantic analysis (LSA) and were then analyzed using multidimensional scaling and cluster analysis. The clusters and scales were interpreted by searching…

  12. Serving Boys through Readers' Advisory

    Sullivan, Michael


    Based on more than twenty years' experience working to get boys interested in reading, the author now offers his first readers' advisory volume. With an emphasis on nonfiction and the boy-friendly categories of genre fiction, the work offers a wealth of material including: (1) Suggestions for how to booktalk one-on-one as well as in large groups;…

  13. Nifedipine for the poor-risk elderly patient with achalasia: objective response demonstrated by solid meal study

    Thomas, E.; Lebow, R.A.; Gubler, R.J.; Bryant, L.R.


    We described an 84-year-old woman with symptomatic achalasia who refused both dilation and surgical treatment. She was treated with the calcium channel blocking drug nifedipine, with significant relief of symptoms. Objective evidence of response to the drug was confirmed by using an egg salad sandwich meal labeled with 99mTc-DTPA

  14. Rural response to climate change in poor countries: Ethics, policies and scientific support systems in their agricultural environment

    Stigter, C.J.


    Sustaning Soil Productivity in Response to Global Climate Change is a two-part text bringing together the latest research in soil science and climatology and the ethical, political and social issues surrounding the stewardship of this vital resource. Chapters include scientific studies on microbial

  15. Nifedipine for the poor-risk elderly patient with achalasia: objective response demonstrated by solid meal study

    Thomas, E.; Lebow, R.A.; Gubler, R.J.; Bryant, L.R.


    We described an 84-year-old woman with symptomatic achalasia who refused both dilation and surgical treatment. She was treated with the calcium channel blocking drug nifedipine, with significant relief of symptoms. Objective evidence of response to the drug was confirmed by using an egg salad sandwich meal labeled with 99mTc-DTPA.

  16. Genetic variations of PIP4K2A confer vulnerability to poor antipsychotic response in severely ill schizophrenia patients.

    Harpreet Kaur

    Full Text Available Literature suggests that disease severity and neurotransmitter signaling pathway genes can accurately identify antipsychotic response in schizophrenia patients. However, putative role of signaling molecules has not been tested in schizophrenia patients based on severity of illness, despite its biological plausibility. In the present study we investigated the possible association of polymorphisms from five candidate genes RGS4, SLC6A3, PIP4K2A, BDNF, PI4KA with response to antipsychotic in variably ill schizophrenia patients. Thus in present study, a total 53 SNPs on the basis of previous reports and functional grounds were examined for their association with antipsychotic response in 423 schizophrenia patients segregated into low and high severity groups. Additionally, haplotype, diplotype, multivariate logistic regression and multifactor-dimensionality reduction (MDR analyses were performed. Furthermore, observed associations were investigated in atypical monotherapy (n = 355 and risperidone (n = 260 treated subgroups. All associations were estimated as odds ratio (OR and 95% confidence interval (CI and test for multiple corrections was applied. Single locus analysis showed significant association of nine variants from SLC6A3, PIP4K2A and BDNF genes with incomplete antipsychotic response in schizophrenia patients with high severity. We identified significant association of six marker diplotype ATTGCT/ATTGCT (rs746203-rs10828317-rs7094131-rs2296624-rs11013052-rs1409396 of PIP4K2A gene in incomplete responders (corrected p-value = 0.001; adjusted-OR = 3.19, 95%-CI = 1.46-6.98 with high severity. These associations were further observed in atypical monotherapy and risperidone sub-groups. MDR approach identified gene-gene interaction among BDNF_rs7103411-BDNF_rs1491851-SLC6A3_rs40184 in severely ill incomplete responders (OR = 7.91, 95%-CI = 4.08-15.36. While RGS4_rs2842026-SLC6A3_rs2975226 interacted synergistically in

  17. Effect of follicular flushing on reproductive outcomes in patients with poor ovarian response undergoing assisted reproductive technology.

    Souza, Anna L M; Sampaio, Marcos; Noronha, Graciele B; Coster, Ludiana G R; de Oliveira, Roberta S G; Geber, Selmo


    The purpose of this study is to investigate the impact of follicular flushing on the number of oocytes retrieved, oocyte maturity, fertilization rate, embryo development, and pregnancy rate of poor ovarian responders (POR). Retrospective study of 524 cycles of 384 patients with POR submitted to assisted reproductive technology (ART) and who had follicular flushing during oocyte retrieval was used in the study. We included patients with <5 oocytes at oocyte retrieval (POR group) and matching the Bologna criteria. POR patients had a mean age of 38.2 ± 4.2 years. A total of 1355 follicles (mean = 3.5 ± 1.6) were aspirated and 1040 oocytes recovered, with 709 (68.2%) obtained by direct aspiration and 331 (31.8%) by follicular flushing. We found a difference between the total number of oocytes and the number of aspirated oocytes. Overall pregnancy rate was 22%. Association was observed between pregnancy rate and the number of oocytes retrieved, the number of MII oocytes, and the number of embryos transferred. The patients matching the Bologna criteria had a mean age of 38.9 ± 3.9 years. A total of 309 follicles were aspirated (mean = 3.1 ± 1.5) and 242 oocytes recovered, with 156 (64.5%) obtained by direct aspiration and 86 (35.5%) by follicular flushing. There was a significant difference between the total number of oocytes and the number of aspirated oocytes. Overall pregnancy rate was 12.1%. There was no association between the pregnancy rate and the number of oocytes retrieved, the number of MII, and the number of embryos. Follicular flushing might be a suitable alternative to increase the number of oocytes and pregnancy rates in patients with POR.

  18. Reader error during CT colonography: causes and implications for training

    Slater, Andrew; Tam, Emily; Gartner, Louise; Scarth, Julia; Peiris, Chand; Gupta, Arun; Marshall, Michele; Burling, David; Taylor, Stuart A.; Halligan, Steve


    This study investigated the variability in baseline computed tomography colonography (CTC) performance using untrained readers by documenting sources of error to guide future training requirements. Twenty CTC endoscopically validated data sets containing 32 polyps were consensus read by three unblinded radiologists experienced in CTC, creating a reference standard. Six readers without prior CTC training [four residents and two board-certified subspecialty gastrointestinal (GI) radiologists] read the 20 cases. Readers drew a region of interest (ROI) around every area they considered a potential colonic lesion, even if subsequently dismissed, before creating a final report. Using this final report, reader ROIs were classified as true positive detections, true negatives correctly dismissed, true detections incorrectly dismissed (i.e., classification error), or perceptual errors. Detection of polyps 1-5 mm, 6-9 mm, and ≥10 mm ranged from 7.1% to 28.6%, 16.7% to 41.7%, and 16.7% to 83.3%, respectively. There was no significant difference between polyp detection or false positives for the GI radiologists compared with residents (p=0.67, p=0.4 respectively). Most missed polyps were due to failure of detection rather than characterization (range 82-95%). Untrained reader performance is variable but generally poor. Most missed polyps are due perceptual error rather than characterization, suggesting basic training should focus heavily on lesion detection. (orig.)

  19. High serum soluble tumor necrosis factor receptor 1 predicts poor treatment response in acute-stage schizophrenia.

    Nishimon, Shohei; Ohnuma, Tohru; Takebayashi, Yuto; Katsuta, Narimasa; Takeda, Mayu; Nakamura, Toru; Sannohe, Takahiro; Higashiyama, Ryoko; Kimoto, Ayako; Shibata, Nobuto; Gohda, Tomohito; Suzuki, Yusuke; Yamagishi, Sho-Ichi; Tomino, Yasuhiko; Arai, Heii


    Inflammation may be involved in the pathophysiology of schizophrenia. However, few cross-sectional or longitudinal studies have examined changes in biomarker expression to evaluate diagnostic and prognostic efficacy in acute-stage schizophrenia. We compared serum inflammatory biomarker concentrations in 87 patients with acute-stage schizophrenia on admission to 105 age-, sex-, and body mass index (BMI)-matched healthy controls. The measured biomarkers were soluble tumor necrosis factor receptor 1 (sTNFR1) and adiponectin, which are associated with inflammatory responses, and pigment epithelium-derived factor (PEDF), which has anti-inflammatory properties. We then investigated biomarker concentrations and associations with clinical factors in 213 patients (including 42 medication-free patients) and 110 unmatched healthy controls to model conditions typical of clinical practice. Clinical symptoms were assessed using the Brief Psychiatric Rating Scale and Global Assessment of Function. In 121 patients, biomarker levels and clinical status were evaluated at both admission and discharge. Serum sTNFR1 was significantly higher in patients with acute-stage schizophrenia compared to matched controls while no significant group differences were observed for the other markers. Serum sTNFR1 was also significantly higher in the 213 patients compared to unmatched controls. The 42 unmedicated patients had significantly lower PEDF levels compared to controls. Between admission and discharge, sTNFR1 levels decreased significantly; however, biomarker changes did not correlate with clinical symptoms. The discriminant accuracy of sTNFR1 was 93.2% between controls and patients, showing no symptom improvement during care. Inflammation and a low-level anti-inflammatory state may be involved in both schizophrenia pathogenesis and acute-stage onset. High serum sTNFR1 in the acute stage could be a useful prognostic biomarker for treatment response in clinical practice. Copyright © 2017

  20. Oligoclonal CD8+ T-cell expansion in patients with chronic hepatitis C is associated with liver pathology and poor response to interferon-alpha therapy.

    Manfras, Burkhard J; Weidenbach, Hans; Beckh, Karl-Heinz; Kern, Peter; Möller, Peter; Adler, Guido; Mertens, Thomas; Boehm, Bernhard O


    The role of CD8(+) T lymphocytes in chronic hepatitis C virus (HCV) infection and in liver injury with subsequent development of fibrosis and cirrhosis is poorly understood. To address this question, we performed a follow-up study including 27 chronically HCV-infected individuals. We determined clonality and phenotypes of circulating CD8(+) T cells employing TCRBV spectratyping. Antigen specificity was tested by rMHC-peptide tetramer staining and stimulation with recombinant HCV antigens. In addition, T-cell clonality and phenotypes were followed during the variable clinical response of interferon- (IFN) alpha treatment. We could demonstrate that CD8(+) T-cell expansions were significantly associated with liver fibrosis and cirrhosis. Likewise, increased oligoclonality of circulating CD8(+) T cells in chronic HCV infection was identified as an indicator for poor clinical response to IFN-alpha therapy. Moreover, we also found that IFN-alpha therapy enhanced the differentiation of CD8(+) T cells towards a late differentiation phenotype (CD28(-) CD57(+)). In cases of virus elimination the disappearance of expanded terminally differentiated CD8(+) cells was observed. Thus, this study identifies an association of clonal expansions of circulating CD8(+) T cells with liver pathology and provides a possible explanation for the fact that response to IFN-alpha therapy diminishes with the duration of infection.

  1. An IoT Reader for Wireless Passive Electromagnetic Sensors.

    Galindo-Romera, Gabriel; Carnerero-Cano, Javier; Martínez-Martínez, José Juan; Herraiz-Martínez, Francisco Javier


    In the last years, many passive electromagnetic sensors have been reported. Some of these sensors are used for measuring harmful substances. Moreover, the response of these sensors is usually obtained with laboratory equipment. This approach highly increases the total cost and complexity of the sensing system. In this work, a novel low-cost and portable Internet-of-Things (IoT) reader for passive wireless electromagnetic sensors is proposed. The reader is used to interrogate the sensors within a short-range wireless link avoiding the direct contact with the substances under test. The IoT functionalities of the reader allows remote sensing from computers and handheld devices. For that purpose, the proposed design is based on four functional layers: the radiating layer, the RF interface, the IoT mini-computer and the power unit. In this paper a demonstrator of the proposed reader is designed and manufactured. The demonstrator shows, through the remote measurement of different substances, that the proposed system can estimate the dielectric permittivity. It has been demonstrated that a linear approximation with a small error can be extracted from the reader measurements. It is remarkable that the proposed reader can be used with other type of electromagnetic sensors, which transduce the magnitude variations in the frequency domain.

  2. Making a Commitment to Strategic-Reader Training



    Skilled readers by definition are strategic; they are able to use a repertoire of reading strategies , flexibly and in meaningful combinations , to achieve their reading comprehension goals . Thus , one of the aims of foreign and second language (L2) reading curricula should be to move students toward becoming more strategic readers . This curricular orientation can be best achieved when a strong commitment is made to strategic-reader training as a regular and consistent component of instruction across the curriculum . To explore this stance , we examine the reading strategies used by skilled readers , contrast teaching strategies with training strategic readers ( i .e . , strategic-reader training) , and examine five strategic-reader training approaches from first language contexts that can be adapted by L2 professionals to enhance the reading instruction offered in their L 2 classes . The five approaches targeted for exploration include Directed Reading-Thinking Activity , Reciprocal Teaching , Transactional Strategies Instruction , Questioning the Author , and Concept-Oriented Reading Instruction . Though distinct from one another , they all acknowledge the importance of explicit explanations about strategies (or reminders about the use of select strategies) , teacher modeling , scaffolded tasks , active student engagement , student practice , classroom discussions of strategy use , and the gradual release of responsibility to students who eventually decide for themselves (and/or with peers) when , where , and why to use which strategies to achieve their comprehension goals . We conclude with a discussion of the challenges , and suggestions for overcoming them , that L 2 teachers and students often face in making a commitment to strategic-reader training .

  3. Association of Low B Cell Count and IgG Levels With Infection, and Poor Vaccine Response With All-Cause Mortality in an Immunosuppressed Vasculitis Population.

    David Morgan, Matthew; Richter, Alex; Al-Ali, Samer; Flint, Julia; Yiannakis, Constantina; Drayson, Mark; Goldblatt, David; Harper, Lorraine


    Patients with systemic vasculitis (SV) have an increased risk of all-cause mortality, often due to infection, compared to the healthy population. We investigated whether humoral response to vaccination and biomarkers of immune dysfunction were associated with infection and death. Patients with SV in remission were vaccinated with pneumococcal 7-valent conjugate, Haemophilus influenzae type b, and meningococcal group C conjugate vaccine and meningococcal polysaccharide groups A, C, Y, and W135 vaccines. Total IgG and antibody titers against specific antigens and lymphocyte subset analysis were performed before vaccination. Postvaccination antibody titers were measured at 4 weeks and 2 years, from which an antibody response score was calculated. Infections and death following vaccination were collected prospectively following vaccination. A total of 92 patients were safely vaccinated with no increase in disease relapse, median followup 4.6 years (interquartile range [IQR] 3.6-4.8 years). Eighteen patients died at a median of 2 years and the overall infection rate was 0.4 (IQR 0.2-1.3) infections/patient/year. Reduced serum IgG, B cell count, and CD4+ cell counts predicted poor vaccine response and infection but not death. The response rates to individual vaccine antigens was highly variable, with a median response rate of 46% (IQR 39-58%) of patients responding to each individual antigen. Vaccine response, age, and reduced renal function were independent predictors of all-cause mortality in multivariate analysis. Total IgG and B cell counts predict infection and response to vaccination. Vaccination in patients with SV in remission is safe and the response predicts all-cause mortality. Vaccine response is a surrogate marker of immune system health. © 2016, American College of Rheumatology.

  4. Metabolic syndrome is associated with poor treatment response to antiviral therapy in chronic hepatitis C genotype 3 patients.

    Aziz, Hafsa; Gill, Uzma; Raza, Abida; Gill, Muzaffar L


    Hepatitis C viral (HCV) infection is caused by an RNA virus. HCV infection is considered to induce systemic disease that causes steatosis, alters lipid metabolism, and results in metabolic syndrome. This study aimed to investigate the therapeutic outcome in HCV genotype 3 patients with metabolic syndrome. A total of 621 HCV-positive patients who visited the hospital for treatment were screened. Among these, 441 patients were enrolled for antiviral therapy. These enrolled patients were assessed for metabolic syndrome according to the International Diabetes Federation criteria. Group A included patients with metabolic syndrome and group B included patients without metabolic syndrome. All patients received peginterferon-α2a (180 μg/week) and ribavirin (10 mg/kg/day) for 6 months. The prevalence of metabolic syndrome in chronic HCV patients was 37.9%. We observed that metabolic syndrome was more common among female compared with male participants (43.9 vs. 28.8%, P=0.005). It was found that sustained virologic response (SVR) rates were significantly higher in the patients in group B (without metabolic syndrome) compared with the patients in group A who had metabolic syndrome (72.2 vs. 43.7%, Pmetabolic syndrome and a correlation of metabolic syndrome with nonresponse to antiviral therapy was observed. An interesting correlation among metabolic syndrome, age, and SVR was found: with age, SVR decreases, while metabolic syndrome increases. Metabolic syndrome has an influence on therapeutic outcomes in terms of SVR. Moreover, this information can identify patients who might have a low chance of attaining an SVR and a timely decision may protect the patients from the adverse effects of therapy.

  5. Angels and demons: Th17 cells represent a beneficial response, while neutrophil IL-17 is associated with poor prognosis in squamous cervical cancer.

    Punt, Simone; Fleuren, Gert Jan; Kritikou, Eva; Lubberts, Erik; Trimbos, J Baptist; Jordanova, Ekaterina S; Gorter, Arko


    The role of interleukin (IL)-17 in cancer remains controversial. In view of the growing interest in the targeting of IL-17, knowing its cellular sources and clinical implications is crucial. In the present study, we unraveled the phenotype of IL-17 expressing cells in cervical cancer using immunohistochemical double and immunofluorescent triple stainings. In the tumor stroma, IL-17 was found to be predominantly expressed by neutrophils (66%), mast cells (23%), and innate lymphoid cells (8%). Remarkably, T-helper 17 (Th17) cells were a minor IL-17 expressing population (4%). A similar distribution was observed in the tumor epithelium. The Th17 and granulocyte fractions were confirmed in head and neck, ovarian, endometrial, prostate, breast, lung, and colon carcinoma. An above median number of total IL-17 expressing cells was an independent prognostic factor for poor disease-specific survival in early stage disease ( p = 0.016). While a high number of neutrophils showed at trend toward poor survival, the lowest quartile of mast cells correlated with poor survival ( p = 0.011). IL-17 expressing cells and neutrophils were also correlated with the absence of vaso-invasion ( p < 0.01). IL-17 was found to increase cell growth or tightness of cervical cancer cell lines, which may be a mechanism for tumorigenesis in early stage disease. These data suggest that IL-17, primarily expressed by neutrophils, predominantly promotes tumor growth, correlated with poor prognosis in early stage disease. Strikingly, a high number of Th17 cells was an independent prognostic factor for improved survival ( p = 0.026), suggesting Th17 cells are part of a tumor suppressing immune response.

  6. Semantic processing in deaf and hard-of-hearing children: Large N400 mismatch effects in brain responses, despite poor semantic ability

    Petter Kallioinen


    Full Text Available Difficulties in auditory and phonological processing affect semantic processing in speech comprehension of deaf and hard-of-hearing (DHH children. However, little is known about brain responses of semantic processing in this group. We investigated event-related potentials (ERPs in DHH children with cochlear implants (CI and/or hearing aids (HA, and in normally hearing controls (NH. We used a semantic priming task with spoken word primes followed by picture targets. In both DHH children and controls, response differences between matching and mismatching targets revealed a typical N400-effect associated with semantic processing. Children with CI had the largest mismatch response despite poor semantic abilities overall, children with CI also had the largest ERP differentiation between mismatch types, with small effects of within-category mismatches (target from same category as prime and large effects between-category mismatches (were target is from a different category than prime. NH and HA children had similar responses to both mismatch types. While the large and differentiated ERP responses in the CI group were unexpected and should be interpreted with caution, the results could reflect less precision in semantic processing among children with CI, or a stronger reliance on predictive processing.

  7. Optimal cutoff value of basal anti-mullerian hormone in iranian infertile women for prediction of ovarian hyper-stimulation syndrome and poor response to stimulation.

    Aghssa, Malek Mansour; Tarafdari, Azam Manshadi; Tehraninejad, Ensieh Shahrokh; Ezzati, Mohammad; Bagheri, Maryam; Panahi, Zahra; Mahdavi, Saeed; Abbasi, Mehrshad


    We intended to establish the threshold of Anti-Mullerian Hormone (AMH) for detection of Ovarian Hyper-Stimulation Syndrome (OHSS) and poor response to treatment in Iranian infertile women. Pre-stimulation menstrual cycle day-3 hormonal indices including basal AMH values were measured in 105 infertile women aged 32.5 ± 4.3 years. Patients underwent long GnRH agonist Controlled Ovarian Hyperstimulation (COH) in a referral infertility center (Tehran, Iran). The gonadotropin dose was determined based on the age and basal serum Follicular Stimulating Hormone (FSH) level. The IVF/ICSI cycles were followed and the clinical and sonographic data were recorded. Sixteen cases developed OHSS. The prevalence of PCOS was higher in subjects with OHSS [62.5 % (38.8-86.2) vs. 17 % (9.2-24.9)]. The patients with OHSS had higher ovarian follicular count [23.7 (3.2) vs. 9.1 (0.5); p Basal AMH level and oocyte yields (but not age, BMI, and PCOS) correlated with occurrence of OHSS; and only the AMH levels were associated with poor ovarian response (oocytes yield ≤ 4). The optimal cutoff value for the prediction of OHSS was 6.95 ng/ml (area under the receiver operating characteristics curve: 0.86; CI: 0.78-0.95; sensitivity: 75 %; specificity: 84 %; odds ratio for occurrence of OHSS: 9 and p basal AMH level > 6.95 ng/ml are at high risk of developing OHSS and those with AMH level < 1.65 ng/ml are poor responders.

  8. Effect of sitagliptin on blood glucose control in patients with type 2 diabetes mellitus who are treatment naive or poorly responsive to existing antidiabetic drugs: the JAMP study.

    Sakura, Hiroshi; Hashimoto, Naotake; Sasamoto, Kazuo; Ohashi, Hiroshi; Hasumi, Sumiko; Ujihara, Noriko; Kasahara, Tadasu; Tomonaga, Osamu; Nunome, Hideo; Honda, Masashi; Iwamoto, Yasuhiko


    To investigate the ameliorating effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood glucose control in patients with type 2 diabetes mellitus who were previously untreated with or who have a poor responsive to existing antidiabetic drugs. Sitagliptin (50 mg/day) was added on to the pre-existing therapy for type 2 diabetes and changes in the glycated hemoglobin (HbA1c) level after 3 months of treatment were compared with the baseline and performed exploratory analysis. HbA1c levels were significantly decreased after 1 month of treatment compared to baseline, with a mean change in HbA1c level from baseline of -0.73% (range, -0.80 to -0.67) in the entire study population at 3 months. Patients who received a medium dose of glimepiride showed the least improvement in HbA1c levels. The percentage of patients who achieved an HbA1c level of blood glucose level of type 2 diabetes mellitus who were previously untreated with, or poorly responsive to, existing antidiabetic drugs. Thus, sitagliptin is expected to be useful in this patient group. However, the additional administration of sitagliptin in patients treated with medium-dose glimepiride only slightly improved blood glucose control when corrected for baseline HbA1c level.

  9. Association of the TYMS 3G/3G genotype with poor response and GGH 354GG genotype with the bone marrow toxicity of the methotrexate in RA patients.

    Jekic, Biljana; Lukovic, Ljiljana; Bunjevacki, Vera; Milic, Vera; Novakovic, Ivana; Damnjanovic, Tatjana; Milasin, Jelena; Popovic, Branka; Maksimovic, Nela; Damjanov, Nemanja; Radunovic, Goran; Kovacevic, Ljiljana; Krajinovic, Maja


    Gamma-glutamyl hydrolase (GGH), cyclin D1 (CCND1) and thymidylate synthase (TS) genes encode enzymes that are involved in methotrexate (MTX) action. In a group of 184 RA patients treated with MTX, we have investigated whether selected polymorphisms in these genes modulate MTX efficacy and/or have impact on adverse drug effects (ADEs). The efficacy of the MTX therapy has been estimated using the disease activity score in 28 joints (DAS28-ESR) based on EULAR criteria and relative DAS28 values (rDAS28). All adverse drug events were recorded. Patients were genotyped for selected polymorphisms of the GGH (-354 G > T and 452 C > T), CCND1 (870 A > G) and TYMS (variable number of tandem repeats, VNTR, and G to C substitution of triple repeat, 3R allele) gene. Association studies have been performed between obtained genotypes and the efficacy and toxicity of MTX. According to the EULAR response criteria, 146 RA patients (79.3 %) were classified as responders (good/moderate response) and 38 (20.7 %) as non-responders (poor response). Higher frequency of the TYMS 3 G/3 G genotype has been found among non-responders as compared to individuals with remaining genotypes (p = 0.02). ADEs were recorded in 53 patients. Among those patients eight experienced bone marrow toxicity, all of them carried GGH -354GG genotype (p = 0.003). No other significant association were observed. The 3 G/3 G genotype of the TYMS gene may indicate predisposition of poor response to MTX and GG genotype of GGH -354 T > G polymorphism may have high predictive value for myelosuppression in RA patients.

  10. Extending the E-Z Reader Model of Eye Movement Control to Chinese Readers

    Rayner, Keith; Li, Xingshan; Pollatsek, Alexander


    Chinese readers' eye movements were simulated in the context of the E-Z Reader model, which was developed to account for the eye movements of readers of English. Despite obvious differences between English and Chinese, the model did a fairly good job of simulating the eye movements of Chinese readers. The successful simulation suggests that the…

  11. Integrative analysis of deep sequencing data identifies estrogen receptor early response genes and links ATAD3B to poor survival in breast cancer.

    Kristian Ovaska

    Full Text Available Identification of responsive genes to an extra-cellular cue enables characterization of pathophysiologically crucial biological processes. Deep sequencing technologies provide a powerful means to identify responsive genes, which creates a need for computational methods able to analyze dynamic and multi-level deep sequencing data. To answer this need we introduce here a data-driven algorithm, SPINLONG, which is designed to search for genes that match the user-defined hypotheses or models. SPINLONG is applicable to various experimental setups measuring several molecular markers in parallel. To demonstrate the SPINLONG approach, we analyzed ChIP-seq data reporting PolII, estrogen receptor α (ERα, H3K4me3 and H2A.Z occupancy at five time points in the MCF-7 breast cancer cell line after estradiol stimulus. We obtained 777 ERa early responsive genes and compared the biological functions of the genes having ERα binding within 20 kb of the transcription start site (TSS to genes without such binding site. Our results show that the non-genomic action of ERα via the MAPK pathway, instead of direct ERa binding, may be responsible for early cell responses to ERα activation. Our results also indicate that the ERα responsive genes triggered by the genomic pathway are transcribed faster than those without ERα binding sites. The survival analysis of the 777 ERα responsive genes with 150 primary breast cancer tumors and in two independent validation cohorts indicated the ATAD3B gene, which does not have ERα binding site within 20 kb of its TSS, to be significantly associated with poor patient survival.

  12. Computer-aided detection of lung nodules on multidetector CT in concurrent-reader and second-reader modes: A comparative study

    Matsumoto, Sumiaki; Ohno, Yoshiharu; Aoki, Takatoshi; Yamagata, Hitoshi; Nogami, Munenobu; Matsumoto, Keiko; Yamashita, Yoshiko; Sugimura, Kazuro


    Purpose: To compare the reading times and detection performances of radiologists in concurrent-reader and second-reader modes of computer-aided detection (CAD) for lung nodules on multidetector computed tomography (CT). Materials and Methods: Fifty clinical multidetector CT datasets containing nodules up to 20 mm in diameter were retrospectively collected. For the detection and rating of non-calcified nodules larger than 4 mm in diameter, 6 radiologists (3 experienced radiologists and 3 resident radiologists) independently interpreted these datasets twice, once with concurrent-reader CAD and once with second-reader CAD. The reference standard of nodules in the datasets was determined by the consensus of two experienced chest radiologists. The reading times and detection performances in the two modes of CAD were statistically compared, where jackknife free-response receiver operating characteristic (JAFROC) analysis was used for the comparison of detection performances. Results: Two hundreds and seven nodules constituted the reference standard. Reading time was significantly shorter in the concurrent-reader mode than in the second-reader mode, with the mean reading time for the 6 radiologists being 132 s with concurrent-reader CAD and 210 s with second-reader CAD (p < 0.01). JAFROC analysis revealed no significant difference between the detection performances in the two modes, with the average figure-of-merit value for the 6 radiologists being 0.70 with concurrent-reader CAD and 0.72 with second-reader CAD (p = 0.35). Conclusion: In CAD for lung nodules on multidetector CT, the concurrent-reader mode is more time-efficient than the second-reader mode, and there can be no significant difference between the two modes in terms of detection performance of radiologists

  13. Comparison of microdose GnRH agonist protocol with GnRH antagonist / letrazole protocol in patients with poor ovarian response

    Yiğit Çakıroğlu


    Full Text Available Objective: To compare microdose GnRH agonist (MDL protocol with GnRH antagonist/letrazole (AL protocol in patients with poor ovarian response. Design: Randomised clinical trial. Setting: Kocaeli University Assisted Reproductive Centre Interventions: POR was diagnosed according to ESHRE Bologna criteria in case of presence of 2 out of 3 criteria. In the MDL group (n=27, 40µg/0.2 cc subcutaneous leuprolid acetate was given two times a day starting on the first day of menstrual cycle. On the second day of the cycle, gonadotrophin stimulation was started at 450-600 IU and/or 150 IU human menopausal gonadotrophin (hMG along with leuprolid. In the AL group (n=28, 5 mg letrazole was given for 5 days starting on the second day of the spontaneous cycle and after the 5th day of the cycle, 450-600 IU and/or 150 IU hMG was given. Main Outcome Measures: To compare the outcomes of MDL protocol with AL protocol in patients with poor ovarian response. Results: Stimulation days, total gonadotrophin dose (IU, peak E2 (pg/ml levels, and endometrial thickness were found to be statistically significantly lower in the AL group. While no cases of cycle cancellation was detected in the MDL group, statistically significantly higher rates of cycle cancellation (%35.7, p<0.001 was detected in the AL group. No statistically significant differences were detected in total oocyte numbers (3.7±2.9 vs 2.7±2.2, number of transferred embryos (1.4±0.5 vs 1.4±1.9, pregnancy rates (3/27 (%11.1 vs 2/28 (%7.1 and implantation rates (3/36 (%8.3 vs 2/22 (%9.1 in between the groups. Comment: Although AL protocol is not superior to MDL protocol in poor ovarian response patients, it may be used as an alternative protocol.

  14. Every reader his book – every book its reader?

    Kann-Christensen, Nanna; Balling, Gitte


    ’ advisory and audience development. This is achieved through an analysis of opinions and reflections expressed by 13 managers and librarians in all six county libraries in Denmark. The interviews are analysed through the model which merges three concepts: cultural policy, new public management......Collections are no longer the main attraction in libraries, and libraries are working to find new paths to tread. One strategy is to focus on reading and literature in new and surprising ways. The aim of this article is to enrich an understanding of activities situated in the span between readers...... and professional logics. Our findings show that Danish librarians’ views on readers’ advisory and audience development strike a balance between the experience and empowerment rationales with a prevailing focus on users. A user orientation and focus on user experiences have created a situation wherein the notions...

  15. Infant ERPs Separate Children at Risk of Dyslexia Who Become Good Readers from Those Who Become Poor Readers

    Zuijen, Titia L.; Plakas, Anna; Maassen, Ben A. M.; Maurits, Natasha M.; van der Leij, Aryan


    Dyslexia is heritable and associated with phonological processing deficits that can be reflected in the event-related potentials (ERPs). Here, we recorded ERPs from 2-month-old infants at risk of dyslexia and from a control group to investigate whether their auditory system processes /bAk/ and /dAk/ changes differently. The speech sounds were…

  16. The Effects of a Reader's Theater Instructional Intervention on Second Grade Students' Reading Fluency and Comprehension Skills

    Johnson, Diane D.


    An estimated 75% of students who are poor readers in third grade continue to be lower achieving readers in ninth grade. The National Reading Panel has identified fluency as a prominent cause of reading comprehension problems which ultimately affect overall reading development. The purpose of this study was to test the theoretical framework of…

  17. A Sign Language Screen Reader for Deaf

    El Ghoul, Oussama; Jemni, Mohamed

    Screen reader technology has appeared first to allow blind and people with reading difficulties to use computer and to access to the digital information. Until now, this technology is exploited mainly to help blind community. During our work with deaf people, we noticed that a screen reader can facilitate the manipulation of computers and the reading of textual information. In this paper, we propose a novel screen reader dedicated to deaf. The output of the reader is a visual translation of the text to sign language. The screen reader is composed by two essential modules: the first one is designed to capture the activities of users (mouse and keyboard events). For this purpose, we adopted Microsoft MSAA application programming interfaces. The second module, which is in classical screen readers a text to speech engine (TTS), is replaced by a novel text to sign (TTSign) engine. This module converts text into sign language animation based on avatar technology.

  18. What Reader-Oriented Literary and Cognitive Theories Have to Give to Composing Theory.

    Liebman-Kleine, JoAnne

    In developing an interactive model of composing, this paper discusses three groups of reader-oriented theories, each of which provides composing theorists with some research and theory to use in developing such a model. First the paper discusses the main principle of the literary reader-response theorists--that the meaning and value of texts do…

  19. E-book Reader Devices and Libraries

    Pažur, I.


    Full Text Available Most library studies thematically related to electronic books don't consider readers of electronic books. Only in recent years librarians conduct studies in which they want to find out readers' opinions about the possibilities, advantages and disadvantages of reading using e-readers, as well as their possible application in the libraries.User studies of e-readers have shown that their opinion is generally positive, but great attachment to traditional books is still present, e-readers are still seen only as an additional tool for reading. Sony with its e-reader (the latest Reader model Daily and Reader Store online bookstore ( the only one who cooperate with libraries and has made lending electronic books possible. Cooperation was launched in 2009th,and the New York Public Library was the first library that offered such a service.Cooperation between Sony and libraries, indicates clearly what the near future could be if other online booksellers / publishers begin to follow the model of lending e-books through the libraries over the network. However it is possible that a large online bookstores / publishers consider that the further price reduction of e-readers and electronic books will constantly increase their sales, and in that case lending e-books will be unnecessary.Are the libraries ready for this scenario?

  20. Circulating cytokines and procalcitonin in acute Q fever granulomatous hepatitis with poor response to antibiotic and short-course steroid therapy: a case report

    Chang Lin-Li


    Full Text Available Abstract Background Q fever is a zoonosis distributed worldwide that is caused by Coxiella burnetii infection and the defervescence usually occurs within few days of appropriate antibiotic therapy. Whether the changes of cytokine levels are associated with acute Q fever with persistent fever despite antibiotic therapy had not been investigated before. Case Presentation We report a rare case of acute Q fever granulomatous hepatitis remained pyrexia despite several antibiotic therapy and 6-day course of oral prednisolone. During the 18-month follow-up, the investigation of the serum cytokines profile and procalcitonin (PCT revealed that initially elevated levels of interleukin-2 (IL-2, IL-8, IL-10, and PCT decreased gradually, but the IL-6 remained in low titer. No evidence of chronic Q fever was identified by examinations of serum antibodies against C. burnetii and echocardiography. Conclusions The changes of cytokine levels may be associated with acute Q fever with poor response to treatment and PCT may be an indicator for monitoring the response to treatment.

  1. Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin

    Liu, Wei; Feng, Qian; Li, Ye; Ye, Ling; Hu, Ming; Liu, Zhongqiu


    Emodin is a poorly bioavailable but promising plant-derived anticancer drug candidate. The low oral bioavailability of emodin is due to its extensive glucuronidation in the intestine and liver. Caco-2 cell culture model was used to investigate the interplay between UDP-glucuronosyltransferases (UGTs) and efflux transporters in the intestinal disposition of emodin. Bidirectional transport assays of emodin at different concentrations were performed in the Caco-2 monolayers with or without multidrug resistance-associated protein (MRP) and breast cancer resistance protein (BCRP) efflux transporter chemical inhibitors. The bidirectional permeability of emodin and its glucuronide in the Caco-2 monolayers was determined. Emodin was rapidly metabolized to emodin glucuronide in Caco-2 cells. LTC4, a potent inhibitor of MRP2, decreased the efflux of emodin glucuronide and also substantially increased the intracellular glucuronide level in the basolateral-to-apical (B–A) direction. MK-571, chemical inhibitor of MRP2, MRP3, and MRP4, significantly reduced the efflux of glucuronide in the apical-to-basolateral (A–B) and B–A directions in a dose-dependent manner. However, dipyridamole, a BCRP chemical inhibitor demonstrated no effect on formation and efflux of emodin glucuronide in Caco-2 cells. In conclusion, UGT is a main metabolic pathway for emodin in the intestine, and the MRP family is composed of major efflux transporters responsible for the excretion of emodin glucuronide in the intestine. The coupling of UGTs and MRP efflux transporters causes the extensive metabolism, excretion, and low bioavailability of emodin. -- Highlights: ► Glucuronidation is the main reason for the poor oral bioavailability of emodin. ► Efflux transporters are involved in the excretion of emodin glucuronide. ► The intestine is the main organ for metabolism of emodin.

  2. Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin

    Liu, Wei; Feng, Qian; Li, Ye; Ye, Ling [Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong (China); Hu, Ming, E-mail: [Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong (China); Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030 (United States); Liu, Zhongqiu, E-mail: [Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong (China)


    Emodin is a poorly bioavailable but promising plant-derived anticancer drug candidate. The low oral bioavailability of emodin is due to its extensive glucuronidation in the intestine and liver. Caco-2 cell culture model was used to investigate the interplay between UDP-glucuronosyltransferases (UGTs) and efflux transporters in the intestinal disposition of emodin. Bidirectional transport assays of emodin at different concentrations were performed in the Caco-2 monolayers with or without multidrug resistance-associated protein (MRP) and breast cancer resistance protein (BCRP) efflux transporter chemical inhibitors. The bidirectional permeability of emodin and its glucuronide in the Caco-2 monolayers was determined. Emodin was rapidly metabolized to emodin glucuronide in Caco-2 cells. LTC4, a potent inhibitor of MRP2, decreased the efflux of emodin glucuronide and also substantially increased the intracellular glucuronide level in the basolateral-to-apical (B–A) direction. MK-571, chemical inhibitor of MRP2, MRP3, and MRP4, significantly reduced the efflux of glucuronide in the apical-to-basolateral (A–B) and B–A directions in a dose-dependent manner. However, dipyridamole, a BCRP chemical inhibitor demonstrated no effect on formation and efflux of emodin glucuronide in Caco-2 cells. In conclusion, UGT is a main metabolic pathway for emodin in the intestine, and the MRP family is composed of major efflux transporters responsible for the excretion of emodin glucuronide in the intestine. The coupling of UGTs and MRP efflux transporters causes the extensive metabolism, excretion, and low bioavailability of emodin. -- Highlights: ► Glucuronidation is the main reason for the poor oral bioavailability of emodin. ► Efflux transporters are involved in the excretion of emodin glucuronide. ► The intestine is the main organ for metabolism of emodin.

  3. Reader-Centered Technical Writing

    Narayanan, M.


    Technical writing is an essential part of professional communication and in recent years it has shifted from a genre-based approach. Formerly, technical writing primarily focused on generating templates of documents and sometimes it was creating or reproducing traditional forms with minor modifications and updates. Now, technical writing looks at the situations surrounding the need to write. This involves deep thinking about the goals and objectives of the project on hand. Furthermore, one observes that it is very important for any participatory process to have the full support of management. This support needs to be well understood and believed by employees. Professional writing may be very persuasive in some cases. When presented in the appropriate context, technical writing can persuade a company to improve work conditions ensuring employee safety and timely production. However, one must recognize that lot of professional writing still continues to make use of reports and instruction manuals. Normally, technical and professional writing addresses four aspects. Objective: The need for generating a given professionally written technical document and the goals the document is expected to achieve and accomplish. Clientele: The clientele who will utilize the technical document. This may include the people in the organization. This may also include "unintended readers." Customers: The population that may be affected by the content of the technical document generated. This includes the stakeholders who will be influenced. Environment: The background in which the document is created. Also, the nature of the situation that warranted the generation of the document. Swiss Psychologist Jean Piaget's view of Learning focuses on three aspects. The author likes to extend Jean Piaget's ideas to students, who are asked to prepare and submit Reader-Centered Technical Writing reports and exercises. Assimilation: Writers may benefit specifically, by assimilating a new object into

  4. Teaching the Total Language with Readers Theatre.

    Goodman, Jess A., Jr.

    Reading, writing, speech assignments for special education classes, English as a second language and many other classroom projects can be taught through the involvement created by Readers Theatre. Readers Theatre is the presentation of dialogue-type material in play form. The actors hold the script as they move through it and a narrator's voice…

  5. Using Readers' Theater with Multicultural Literature

    Weisenburger, Stephanie


    The author needed a way to engage her students in the reading process and found one extremely successful strategy: using Readers' Theater. Readers' Theater "dramatizes" literature through a classroom performance and provides visual and oral stimulus to students who are not used to using imagination to appreciate literary texts. It involves a…

  6. Readers Theatre plus Comprehension and Word Study

    Young, Chase; Stokes, Faida; Rasinski, Timothy


    Readers Theatre has been used to introduce critical issues, promote fluency among English learners and non-English learners, teach vocabulary, and integrate content in the classroom. Previous studies of Readers Theatre application have demonstrated an increase in student reading fluency, motivation, and confidence. The focus of this systemic…

  7. The active reader: what is active?

    Woerkum, van C.


    How writers can adapt to their readers is an important issue in effective communication strategies, and certainly crucial in the case of functional texts. Therefore, it is necessary to look at how readers are constructed as partners in a communication co-production. This article explores the concept

  8. Practicum Training for Teachers of Struggling Readers

    Morris, Darrell


    Teachers who work with struggling beginning readers need a supervised training experience that leads them to understand both how reading ability develops and how to adapt instruction to meet the needs of individual children. The practicum, in which a teacher works with one struggling reader under the supervision of an experienced and expert…

  9. Soil solution and sugar maple response to NH(4)NO (3) additions in a base-poor northern hardwood forest of Québec, Canada.

    Moore, Jean-David; Houle, Daniel


    Nitrogen additions (NH4NO3) at rates of three- and ten-fold ambient atmospheric deposition (8.5 kg ha(-1) year(-1)) were realised in an acid- and base-poor northern hardwood forest of Québec, Canada. Soil solution chemistry, foliar chemistry, crown dieback and basal area growth of sugar maple (Acer saccharum Marsh.) were measured. Except for a transitory increase of NO3 and NH4 concentrations, there was no persistent increase in their level in soil solution 3 years after N treatments, with the exception of one plot out of three, that received the highest N addition, beginning to show persistent and high NO3 concentrations after 2 years of N additions. Three years of N additions have significantly increased the N DRIS index of sugar maple but not N foliar concentration. Potassium, Ca and Mn foliar concentrations, as well as P and Ca DRIS indices, decreased in treated plots after 3 years. No treatment effect was observed for basal area growth and dieback rate. One unexpected result was the significant decrease in foliar Ca even in the treated plots that received low N rates, despite the absence of significant NO3-induced leaching of Ca. The mechanism responsible for the decrease in foliar Ca is not known. Our results, however, clearly demonstrate that increased N deposition at sites with low base saturation may affect Ca nutrition even when clear signs of N saturation are not observed.

  10. Parent's responses to nutrient claims and sports celebrity endorsements on energy-dense and nutrient-poor foods: an experimental study.

    Dixon, Helen; Scully, Maree; Wakefield, Melanie; Kelly, Bridget; Chapman, Kathy; Donovan, Robert


    To assess parents' responses to common, potentially misleading strategies for marketing energy-dense and nutrient-poor (EDNP) child-oriented foods. Between-subjects online experiment to test whether nutrient claims and sports celebrity endorsements on the front of packs of EDNP products lead parents to prefer and rate these foods more favourably. Australia. A total of 1551 parents of children aged 5-12 years, who were the main household grocery buyers. Inclusion of nutrient claims or sports celebrity endorsements on EDNP products led parents to perceive these products to be more nutritious than if they did not include such promotions. When asked to choose between a pair of different products (EDNP v. healthier), 56 % of parents did not read a nutrition information panel (NIP) before making their choice and this did not differ by promotion condition. These parents were more likely to choose an EDNP product if it included a nutrient claim (OR = 1.83, 95 % CI 1.31, 2.56; P foods are available to children at home, it is critical that initiatives aimed at reducing the persuasive impact of food marketing include this target group.

  11. Areca nut is associated with younger age of diagnosis, poor chemoradiotherapy response, and shorter overall survival in esophageal squamous cell carcinoma.

    Chang-Han Chen

    Full Text Available Areca nut chewing is carcinogenic to humans. However, little is known about the impact of areca nut chewing on esophageal squamous cell carcinoma (ESCC.We retrospectively reviewed 286 ESCC patients who received surgery or preoperative chemoradiotherapy followed by surgery at our institution. Background characteristics including areca nut chewing history were analyzed. The 4-nitroquinoline 1-oxide (4-NQO-induced murine ESCC model was used to test the impact of arecoline, a main constituent of areca nut, on ESCC.Compared to patients without areca nut chewing history, patients with areca nut chewing history had overall a younger age of onset (Mean age: 56.75 versus 52.68 yrs, P<0.001 and significantly worse overall survival than those without areca nut chewing history (P = 0.026. Among patients who received surgery, the overall survival rates were not significantly different between those with or without areca nut chewing history. Among patients who received preoperative chemoradiotherapy followed by surgery, those with areca nut chewing history had a significantly lower pathologic complete response rate (P = 0.002 and lower overall survival rate (P = 0.002 than those without. In the murine ESCC model, the incidence of esophageal invasive squamous cell carcinoma was 40% in mice exposed to concomitant 4-NQO and arecoline treatment for 8 weeks and 6% in mice exposed to 4-NQO only for 8 weeks (P = 0.037.Our results indicate that areca nut chewing history is significantly associated with younger age of onset, poor response to chemoradiotherapy, and shorter overall survival in ESCC patients. Arecoline, a main constituent of areca nut, accelerates esophageal tumorigenesis in the 4-NQO-induced murine ESCC model.

  12. The value of {sup 18}F-FDG PET before and after induction chemotherapy for the early prediction of a poor pathologic response to subsequent preoperative chemoradiotherapy in oesophageal adenocarcinoma

    Rossum, Peter S.N. van [The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Houston, TX (United States); University Medical Center Utrecht, Department of Radiation Oncology, Utrecht (Netherlands); Fried, David V.; Zhang, Lifei; Court, Laurence E. [The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, Houston, TX (United States); Hofstetter, Wayne L. [The University of Texas MD Anderson Cancer Center, Department of Thoracic and Cardiovascular Surgery, Houston, TX (United States); Ho, Linus [The University of Texas MD Anderson Cancer Center, Department of Gastrointestinal Medical Oncology, Houston, TX (United States); Meijer, Gert J. [University Medical Center Utrecht, Department of Radiation Oncology, Utrecht (Netherlands); Carter, Brett W. [The University of Texas MD Anderson Cancer Center, Department of Diagnostic Radiology, Houston, TX (United States); Lin, Steven H. [The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Houston, TX (United States)


    The purpose of our study was to determine the value of {sup 18}F-FDG PET before and after induction chemotherapy in patients with oesophageal adenocarcinoma for the early prediction of a poor pathologic response to subsequent preoperative chemoradiotherapy (CRT). In 70 consecutive patients receiving a three-step treatment strategy of induction chemotherapy and preoperative chemoradiotherapy for oesophageal adenocarcinoma, {sup 18}F-FDG PET scans were performed before and after induction chemotherapy (before preoperative CRT). SUV{sub max}, SUV{sub mean}, metabolic tumour volume (MTV), and total lesion glycolysis (TLG) were determined at these two time points. The predictive potential of (the change in) these parameters for a poor pathologic response, progression-free survival (PFS) and overall survival (OS) was assessed. A poor pathologic response after induction chemotherapy and preoperative CRT was found in 27 patients (39 %). Patients with a poor pathologic response experienced less of a reduction in TLG after induction chemotherapy (p < 0.01). The change in TLG was predictive for a poor pathologic response at a threshold of -26 % (sensitivity 67 %, specificity 84 %, accuracy 77 %, PPV 72 %, NPV 80 %), yielding an area-under-the-curve of 0.74 in ROC analysis. Also, patients with a decrease in TLG lower than 26 % had a significantly worse PFS (p = 0.02), but not OS (p = 0.18). {sup 18}F-FDG PET appears useful to predict a poor pathologic response as well as PFS early after induction chemotherapy in patients with oesophageal adenocarcinoma undergoing a three-step treatment strategy. As such, the early {sup 18}F-FDG PET response after induction chemotherapy could aid in individualizing treatment by modification or withdrawal of subsequent preoperative CRT in poor responders. (orig.)

  13. The value of 18F-FDG PET before and after induction chemotherapy for the early prediction of a poor pathologic response to subsequent preoperative chemoradiotherapy in oesophageal adenocarcinoma

    Rossum, Peter S.N. van; Fried, David V.; Zhang, Lifei; Court, Laurence E.; Hofstetter, Wayne L.; Ho, Linus; Meijer, Gert J.; Carter, Brett W.; Lin, Steven H.


    The purpose of our study was to determine the value of 18 F-FDG PET before and after induction chemotherapy in patients with oesophageal adenocarcinoma for the early prediction of a poor pathologic response to subsequent preoperative chemoradiotherapy (CRT). In 70 consecutive patients receiving a three-step treatment strategy of induction chemotherapy and preoperative chemoradiotherapy for oesophageal adenocarcinoma, 18 F-FDG PET scans were performed before and after induction chemotherapy (before preoperative CRT). SUV max , SUV mean , metabolic tumour volume (MTV), and total lesion glycolysis (TLG) were determined at these two time points. The predictive potential of (the change in) these parameters for a poor pathologic response, progression-free survival (PFS) and overall survival (OS) was assessed. A poor pathologic response after induction chemotherapy and preoperative CRT was found in 27 patients (39 %). Patients with a poor pathologic response experienced less of a reduction in TLG after induction chemotherapy (p < 0.01). The change in TLG was predictive for a poor pathologic response at a threshold of -26 % (sensitivity 67 %, specificity 84 %, accuracy 77 %, PPV 72 %, NPV 80 %), yielding an area-under-the-curve of 0.74 in ROC analysis. Also, patients with a decrease in TLG lower than 26 % had a significantly worse PFS (p = 0.02), but not OS (p = 0.18). 18 F-FDG PET appears useful to predict a poor pathologic response as well as PFS early after induction chemotherapy in patients with oesophageal adenocarcinoma undergoing a three-step treatment strategy. As such, the early 18 F-FDG PET response after induction chemotherapy could aid in individualizing treatment by modification or withdrawal of subsequent preoperative CRT in poor responders. (orig.)

  14. Age- and ability-related differences in young readers' use of conjunctions.

    Cain, Kate; Patson, Nikole; Andrews, Leanne


    Two studies investigating young readers' use of conjunctions are reported. In Study One, 145 eight- to ten-year-olds completed one of two narrative cloze tasks in which different types of conjunction were deleted. Performance for additive conjunctions was not affected by age in this study, but older children were more likely to select the target conjunction than were younger children for temporal, causal, and adversative terms. Performance was superior in the cloze task in which they were given a restricted choice of responses (three vs. seven). In Study Two, 35 eight- and nine-year-old good and poor comprehenders completed the three-choice cloze task. The poor comprehenders were less likely to select the target terms in general. Sentence-level comprehension skills did not account for their poor performance. The results indicate that understanding of the semantic relations expressed by conjunctions is still developing long after these terms are used correctly in children's speech. The findings are discussed in relation to the role of conjunctions in text comprehension.

  15. Reader practice in mammography screen reporting in Australia

    Reed, W.; Poulos, A.; Brennan, P.


    Full text: Reader variability is a problem in mammography image reporting and compromises the efficacy of screening programmes. The purpose of this exploratory study was to survey reader practice in reporting screening mammograms in Australia to identify aspects of practice that warrant further investigation. Mammography reporting practice and influences on concentration and attention were investigated by using an original questionnaire distributed to screen readers in Australia. A response rate of 71% (83 out of 117) was achieved. Demographic data indicated that the majority of readers were over 46 years of age (73%), have been reporting on screening mammograms for over 10 years (61%), take less than 1 min to report upon a screening mammogram examination (66%), report up to 200 examinations in a single session (83%) and take up to 2 h to report one session (61%). A majority report on more than 5000 examinations annually (66%); 93% of participants regard their search strategy as systematic, 87% agreed that their concentration can vary throughout a session, 64% agreed that the relatively low number of positives can lead to lapses in concentration and attention and almost all (94%) participants agreed that methods to maximise concentration should be explored. Participants identified a range of influences on concentration within their working environment including volume of images reported in one session, image types and aspects of the physical environment. This study has provided important evidence of the need to investigate adverse influences on concentration during mammography screen reporting

  16. A new fully automated TLD badge reader

    Kannan, S.; Ratna, P.; Kulkarni, M.S.


    At present personnel monitoring in India is being carried out using a number of manual and semiautomatic TLD badge Readers and the BARC TL dosimeter badge designed during 1970. Of late the manual TLD badge readers are almost completely replaced by semiautomatic readers with a number of performance improvements like use of hot gas heating to reduce the readout time considerably. PC based design with storage of glow curve for every dosimeter, on-line dose computation and printout of dose reports, etc. However the semiautomatic system suffers from the lack of a machine readable ID code on the badge and the physical design of the dosimeter card not readily compatible for automation. This paper describes a fully automated TLD badge Reader developed in the RSS Division, using a new TLD badge with machine readable ID code. The new PC based reader has a built-in reader for reading the ID code, in the form of an array of holes, on the dosimeter card. The reader has a number of self-diagnostic features to ensure a high degree of reliability. (author)

  17. Using the ovarian sensitivity index to define poor, normal, and high response after controlled ovarian hyperstimulation in the long gonadotropin-releasing hormone-agonist protocol: suggestions for a new principle to solve an old problem.

    Huber, Malin; Hadziosmanovic, Nermin; Berglund, Lars; Holte, Jan


    To explore the utility of using the ratio between oocyte yield and total dose of FSH, i.e., the ovarian sensitivity index (OSI), to define ovarian response patterns. Retrospective cross-sectional study. University-affiliated private center. The entire unselected cohort of 7,520 IVF/intracytoplasmic sperm injection treatments (oocyte pick-ups [OPUs]) during an 8-year period (long GnRH agonist-recombinant FSH protocol). None. The distribution of the OSI (oocytes recovered × 1,000/total dose of FSH), the cutoff levels for poor and high response, set at ±1 SD, and the relationship between OSI and treatment outcome. OSI showed a log-normal distribution with cutoff levels for poor and high response at 1.697/IU and 10.07/IU, respectively. A nomogram is presented. Live-birth rates per OPU were 10.5 ± 0.1%, 26.9 ± 0.6%, and 36.0 ± 1.4% for poor, normal, and high response treatments, respectively. The predictive power (C-statistic) for OSI to predict live birth was superior to that of oocyte yield. The OSI improves the definition of ovarian response patterns because it takes into account the degree of stimulation. The nomogram presents evidence-based cutoff levels for poor, normal, and high response and could be used for unifying study designs involving ovarian response patterns. Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  18. Process Synchronization with Readers and Writers Revisited

    Kawash, Jalal


    The readers-writers problem is one of the very well known problems in concurrency theory. It was first introduced by Courtois in 1971 [1] and requires the synchronization of processes trying to read and write a shared resource. Several readers are allowed to access the resource simultaneously, but a writer must be given exclusive access to that resource. Courtois gave semaphore-based solutions to what they called the first and second readers-writers problems. Both of their solut...

  19. Impaired Upregulation of the Costimulatory Molecules, CD27 and CD28, on CD4+ T Cells from HIV Patients Receiving ART Is Associated with Poor Proliferative Responses.

    Tanaskovic, Sara; Price, Patricia; French, Martyn A; Fernandez, Sonia


    HIV patients beginning antiretroviral therapy (ART) with advanced immunodeficiency often retain low CD4 + T cell counts despite virological control. We examined proliferative responses and upregulation of costimulatory molecules, following anti-CD3 stimulation, in HIV patients with persistent CD4 + T cell deficiency on ART. Aviremic HIV patients with nadir CD4 + T cell counts cells/μL and who had received ART for a median time of 7 (range 1-11) years were categorized into those achieving low (cells/μL; n = 13) or normal (>500 cells/μL; n = 20) CD4 + T cell counts. Ten healthy controls were also recruited. CD4 + T cell proliferation (Ki67) and upregulation of costimulatory molecules (CD27 and CD28) after anti-CD3 stimulation were assessed by flow cytometry. Results were related to proportions of CD4 + T cells expressing markers of T cell senescence (CD57), activation (HLA-DR), and apoptotic potential (Fas). Expression of CD27 and/or CD28 on uncultured CD4 + T cells was similar in patients with normal CD4 + T cell counts and healthy controls, but lower in patients with low CD4 + T cell counts. Proportions of CD4 + T cells expressing CD27 and/or CD28 correlated inversely with CD4 + T cell expression of CD57, HLA-DR, and Fas. After anti-CD3 stimulation, induction of CD27 hi CD28 hi expression was independent of CD4 + T cell counts, but lower in HIV patients than in healthy controls. Induction of CD27 hi CD28 hi expression correlated with induction of Ki67 expression in total, naïve, and CD31 + naïve CD4 + T cells from patients. In HIV patients responding to ART, impaired induction of CD27 and CD28 on CD4 + T cells after stimulation with anti-CD3 is associated with poor proliferative responses as well as greater CD4 + T cell activation and immunosenescence.

  20. microRNA 125a Regulates MHC-I Expression on Esophageal Adenocarcinoma Cells, Associated With Suppression of Anti-tumor Immune Response and Poor Outcomes of Patients.

    Mari, Luigi; Hoefnagel, Sanne J M; Zito, Domenico; van de Meent, Marian; van Endert, Peter; Calpe, Silvia; Sancho Serra, Maria Del Carmen; Heemskerk, Mirjam H M; van Laarhoven, Hanneke W M; Hulshof, Maarten C C M; Gisbertz, Susanne S; Medema, Jan Paul; van Berge Henegouwen, Mark I; Meijer, Sybren L; Bergman, Jacques J G H M; Milano, Francesca; Krishnadath, Kausilia K


    in antigen presentation also expressed high levels of genes that regulate the adaptive immune response, PD-L1, PD-L2, and IDO1; these EACs had a poor response to neo-adjuvant chemoradiotherapy and associated with shorter overall survival times of patients. In studies of EAC cell lines and tumor tissues, we found increased levels of MIR125a-5p and MIR148a-3p to reduce levels of TAP2 and MHC-I, required for antigen presentation. High expression of MHC-I molecules by EAC correlated with markers of an adaptive immune response and significantly shorter overall survival times of patients. Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

  1. Cultural Journalism Publications for Reluctant Readers.

    Hatcher, Barbara


    Provides a list of cultural journalism publications (based on oral history interviews) written, edited, and produced by students around the country that provide good easy reading for older reluctant readers. (MKM)

  2. Face-to-face with the reader



    Full Text Available Thank you for inviting me to this meeting. I understood that it is a meeting of the editorial board with readers. But I would like to note that there is still such a small layer between the editors and readers, which is called the printing house. So it is the typography that materially embodies the ideas, thoughts and innovations of the editorial staff and the authors.

  3. Beyond Phonological and Morphological Processing: Pure Copying as a Marker of Dyslexia in Chinese but Not Poor Reading of English

    Kalindi, Sylvia Chanda; McBride, Catherine; Tong, Xiuhong; Wong, Natalie Lok Lee; Chung, Kien Hoa Kevin; Lee, Chia-Ying


    To examine cognitive correlates of dyslexia in Chinese and reading difficulties in English as a foreign language, a total of 14 Chinese dyslexic children (DG), 16 poor readers of English (PE), and 17 poor readers of both Chinese and English (PB) were compared to a control sample (C) of 17 children, drawn from a statistically representative sample…

  4. Identifying cochlear implant channels with poor electrode-neuron interface: electrically-evoked auditory brainstem responses measured with the partial tripolar configuration

    Bierer, Julie Arenberg; Faulkner, Kathleen F.; Tremblay, Kelly L.


    Objectives The goal of this study was to compare cochlear implant behavioral measures and electrically-evoked auditory brainstem responses (EABRs) obtained with a spatially focused electrode configuration. It has been shown previously that channels with high thresholds, when measured with the tripolar configuration, exhibit relatively broad psychophysical tuning curves (Bierer and Faulkner, 2010). The elevated threshold and degraded spatial/spectral selectivity of such channels are consistent with a poor electrode-neuron interface, such as suboptimal electrode placement or reduced nerve survival. However, the psychophysical methods required to obtain these data are time intensive and may not be practical during a clinical mapping procedure, especially for young children. Here we have extended the previous investigation to determine if a physiological approach could provide a similar assessment of channel functionality. We hypothesized that, in accordance with the perceptual measures, higher EABR thresholds would correlate with steeper EABR amplitude growth functions, reflecting a degraded electrode-neuron interface. Design Data were collected from six cochlear implant listeners implanted with the HiRes 90k cochlear implant (Advanced Bionics). Single-channel thresholds and most comfortable listening levels were obtained for stimuli that varied in presumed electrical field size by using the partial tripolar configuration, for which a fraction of current (σ) from a center active electrode returns through two neighboring electrodes and the remainder through a distant indifferent electrode. EABRs were obtained in each subject for the two channels having the highest and lowest tripolar (σ=1 or 0.9) behavioral threshold. Evoked potentials were measured with both the monopolar (σ=0) and a more focused partial tripolar (σ ≥ 0.50) configuration. Results Consistent with previous studies, EABR thresholds were highly and positively correlated with behavioral thresholds

  5. Identifying cochlear implant channels with poor electrode-neuron interfaces: electrically evoked auditory brain stem responses measured with the partial tripolar configuration.

    Bierer, Julie Arenberg; Faulkner, Kathleen F; Tremblay, Kelly L


    The goal of this study was to compare cochlear implant behavioral measures and electrically evoked auditory brain stem responses (EABRs) obtained with a spatially focused electrode configuration. It has been shown previously that channels with high thresholds, when measured with the tripolar configuration, exhibit relatively broad psychophysical tuning curves. The elevated threshold and degraded spatial/spectral selectivity of such channels are consistent with a poor electrode-neuron interface, defined as suboptimal electrode placement or reduced nerve survival. However, the psychophysical methods required to obtain these data are time intensive and may not be practical during a clinical mapping session, especially for young children. Here, we have extended the previous investigation to determine whether a physiological approach could provide a similar assessment of channel functionality. We hypothesized that, in accordance with the perceptual measures, higher EABR thresholds would correlate with steeper EABR amplitude growth functions, reflecting a degraded electrode-neuron interface. Data were collected from six cochlear implant listeners implanted with the HiRes 90k cochlear implant (Advanced Bionics). Single-channel thresholds and most comfortable listening levels were obtained for stimuli that varied in presumed electrical field size by using the partial tripolar configuration, for which a fraction of current (σ) from a center active electrode returns through two neighboring electrodes and the remainder through a distant indifferent electrode. EABRs were obtained in each subject for the two channels having the highest and lowest tripolar (σ = 1 or 0.9) behavioral threshold. Evoked potentials were measured with both the monopolar (σ = 0) and a more focused partial tripolar (σ ≥ 0.50) configuration. Consistent with previous studies, EABR thresholds were highly and positively correlated with behavioral thresholds obtained with both the monopolar and partial

  6. Optimised to Fail: Card Readers for Online Banking

    Drimer, Saar; Murdoch, Steven J.; Anderson, Ross

    The Chip Authentication Programme (CAP) has been introduced by banks in Europe to deal with the soaring losses due to online banking fraud. A handheld reader is used together with the customer’s debit card to generate one-time codes for both login and transaction authentication. The CAP protocol is not public, and was rolled out without any public scrutiny. We reverse engineered the UK variant of card readers and smart cards and here provide the first public description of the protocol. We found numerous weaknesses that are due to design errors such as reusing authentication tokens, overloading data semantics, and failing to ensure freshness of responses. The overall strategic error was excessive optimisation. There are also policy implications. The move from signature to PIN for authorising point-of-sale transactions shifted liability from banks to customers; CAP introduces the same problem for online banking. It may also expose customers to physical harm.

  7. Microfluidic point-of-care diagnostics for resource-poor environments

    Laksanasopin, Tassaneewan; Chin, Curtis D.; Moore, Hannah; Wang, Jennifer; Cheung, Yuk Kee; Sia, Samuel K.


    Point-of-care (POC) diagnostics have tremendous potential to improve human health in remote and resource-poor settings. However, the design criteria for diagnostic tests appropriate in settings with limited infrastructure are unique and challenging. Here we present a custom optical reader which quantifies silver absorbance from heterogeneous immunoassays. The reader is simple and low-cost and suited for POC diagnostics.

  8. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial

    Marina, Neyssa M.; Smeland, Sigbjørn; Bielack, Stefan S.; Bernstein, Mark; Jovic, Gordana; Krailo, Mark D.; Hook, Jane M.; Arndt, Carola; van den Berg, Henk; Brennan, Bernadette; Brichard, Bénédicte; Brown, Ken L. B.; Butterfass-Bahloul, Trude; Calaminus, Gabriele; Daldrup-Link, Heike E.; Eriksson, Mikael; Gebhardt, Mark C.; Gelderblom, Hans; Gerss, Joachim; Goldsby, Robert; Goorin, Allen; Gorlick, Richard; Grier, Holcombe E.; Hale, Juliet P.; Hall, Kirsten Sundby; Hardes, Jendrik; Hawkins, Douglas S.; Helmke, Knut; Hogendoorn, Pancras C. W.; Isakoff, Michael S.; Janeway, Katherine A.; Jürgens, Heribert; Kager, Leo; Kühne, Thomas; Lau, Ching C.; Leavey, Patrick J.; Lessnick, Stephen L.; Mascarenhas, Leo; Meyers, Paul A.; Mottl, Hubert; Nathrath, Michaela; Papai, Zsuzsanna; Randall, R. Lor; Reichardt, Peter; Renard, Marleen; Safwat, Akmal Ahmed; Schwartz, Cindy L.; Stevens, Michael C. G.; Strauss, Sandra J.; Teot, Lisa; Werner, Mathias; Sydes, Matthew R.; Whelan, Jeremy S.


    We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma. EURAMOS-1 was an open-label,

  9. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOSan open-label, international, randomised controlled trial-1): an open-label, international, randomised controlled trial

    Marina, Neyssa M; Smeland, Sigbjørn; Bielack, Stefan S


    BACKGROUND: We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma. METHODS: EURAMOS-1 wa...

  10. The differential effects of position, ad and reader characteristics on readers' processing of newspaper ads

    Smit, E.G.; Neijens, P.C.; Heath, R.


    Building on previous research on the processing of newspaper ads, this comprehensive field study, with 26,556 newspaper readers and 290 unique advertisements, investigated the combined effects of position in the newspaper, ad characteristics and reader characteristics. The results show a

  11. Microcomputer control of automated TL reader

    Bjarland, B.


    An automatic TL reader has been developed for use within a TLD based personal monitoring service. A 6800 based microcomputer is used for system control, operator communication, calibration and checking of reader operation, and for output of data. The dosimeter identity code is printed in human readable characters on the dosimeter card, and is read by using an optical character recognition unit. The code may include individual sensitivity correction coefficients for the TL chips on the card. The chips are heated with hot nitrogen gas and the thermoluminescence is recorded by a photomultiplier tube circuit, the gain and offset of which are continuously monitored and, when necessary, adjusted, to maintain calibration. The reader may operate in any of seven modes, i.e. reading modes for three types of dosimeters, semiautomatic modes for production of the three types of dosimeters, and a monitor mode. (Auth.)

  12. Postdecisional counterfactual thinking by actors and readers.

    Girotto, Vittorio; Ferrante, Donatella; Pighin, Stefania; Gonzalez, Michel


    How do individuals think counterfactually about the outcomes of their decisions? Most previous studies have investigated how readers think about fictional stories, rather than how actors think about events they have actually experienced. We assumed that differences in individuals' roles (actor vs. reader) can make different information available, which in turn can affect counterfactual thinking. Hence, we predicted an effect of role on postdecisional counterfactual thinking. Reporting the results of eight studies, we show that readers undo the negative outcome of a story by undoing the protagonist's choice to tackle a given problem, rather than the protagonist's unsuccessful attempt to solve it. But actors who make the same choice and experience the same negative outcome as the protagonist undo this outcome by altering features of the problem. We also show that this effect does not depend on motivational factors. These results contradict current accounts of counterfactual thinking and demonstrate the necessity of investigating the counterfactual thoughts of individuals in varied roles.

  13. Reader construction in interactive online journalism

    Hartley, Jannie Møller

    how online journalists are constructing their readers, seeking to explain how these views affect practices of journalism. Gans idea of the “constructed public” is re-visited, by analyzing the newsroom negotiations between one hand enabling the user participation and on the other hand their very...... be seen as journalistic positioning strategies and interactivity and mediated connectivity as both vital and challenging for the very field of journalism. This indicates that not only do the different kinds of interactivity seem to imply different kind of readers – they also seem to imply different ideals...

  14. Passive microfluidic array card and reader

    Dugan, Lawrence Christopher [Modesto, CA; Coleman, Matthew A [Oakland, CA


    A microfluidic array card and reader system for analyzing a sample. The microfluidic array card includes a sample loading section for loading the sample onto the microfluidic array card, a multiplicity of array windows, and a transport section or sections for transporting the sample from the sample loading section to the array windows. The microfluidic array card reader includes a housing, a receiving section for receiving the microfluidic array card, a viewing section, and a light source that directs light to the array window of the microfluidic array card and to the viewing section.

  15. The comprehension of Italian relative clauses in poor readers and in children with Specific Language Impairment

    Fabrizio Arosio


    Full Text Available Children with Specific Language Impairment (SLI and children with Developmental Dyslexia (DD have problems comprehending relative clauses (RCs and find object RCs more difficult than subject RCs, as do typically developing children. Few studies have compared these groups directly, leaving it unclear whether the problems observed in children with DD are similar to those described in SLI. Work with typically developing children has shown that the comprehension of passive RCs is less challenging than that of object RCs. It is argued that this asymmetry depends on intervention effects as modelized in a Relativized Minimality framework. Since movement is challenging for children with SLI and those with DD, examining and comparing their comprehension of object RCs and passive RCs can broaden our understanding of their language deficits. In fact, both structures involve movement, but the moved element and the movement configuration are different. In our study we investigated the comprehension of subject RCs, object RCs and passive RCs in 12 Italian monolingual children with SLI (mean age: 7;6, 13 Italian monolingual children with DD (mean age: 10;7 and 50 typically developing controls matched for age, grammar and vocabulary. Results from a picture selection task show that: (i subject RCs are unproblematic for all children; (ii object RCs are challenging for children with SLI, children with DD and younger typically developing controls; (iii passive RCs are better understood than object RCs in all groups, but still problematic for children with SLI and younger typically developing controls. Our data show that intervention effects are found in children with SLI and children with DD and that those with SLI have a deficit in transferring thematic roles to moved elements. Our results point out that some of the children with DD have a mild grammatical deficit that was undetected or escaped standardized tests.

  16. Map Feature Content and Text Recall of Good and Poor Readers.

    Amlund, Jeanne T.; And Others


    Reports two experiments evaluating the effect of map feature content on text recall by subjects of varying reading skill levels. Finds that both experiments support the conjoint retention hypothesis, in which dual-coding of spatial and verbal information and their interaction in memory enhance recall. (MM)

  17. Exploring Intrinsic and Extrinsic Reading Motivation among Very Good and Very Poor Readers

    McGeown, Sarah P.; Norgate, Roger; Warhurst, Amy


    Background: Research examining the relationship between reading skill and reading motivation has typically been carried out among children with a wide range of reading abilities. There is less research focusing on children who excel in reading or who are attaining very low reading scores. Purpose: To examine whether there were differences between…

  18. Morphosyntax and Logical Abilities in Italian Poor Readers: The Problem of SLI Under-Identification

    Arosio, Fabrizio; Pagliarini, Elena; Perugini, Maria; Barbieri, Lina; Guasti, Maria Teresa


    The study investigated morphosyntactic abilities and semantic-pragmatic competence in 24 children with developmental dyslexia aged 7-12 years. Morphosyntactic abilities were investgated in a direct object clitic production task, semantic-pragmatic competence in a quantifier comprehension task. Children with dyslexia produced fewer clitics than…

  19. Using Concept Mapping to Improve Poor Readers' Understanding of Expository Text

    Morfidi, Eleni; Mikropoulos, Anastasios; Rogdaki, Aspasia


    The present study examined whether the use of concept mapping is more effective in teaching expository material in comparison to a traditional, lecture only, approach. Its objective was threefold. First, to determine if multimedia concept mapping produces differential learning outcomes compared to digital text-based concept mapping. Secondly, to…

  20. Impact of letrozole on ultrasonographic markers of endometrial receptivity in polycystic ovary syndrome women with poor endometrial response to clomiphene citrate despite adequate ovulation

    Ahmed Walid A. Morad


    Conclusion: Letrozole is an effective second-line treatment in women with inadequate endometrial response to CC, as letrozole increased endometrial thickness trilaminar pattern and improved endometrial perfusion.

  1. Rights of Postsecondary Readers and Learners

    Greenbaum, JoAnne; Angus, Kathryn Bartle


    A position statement on the rights of adult readers and learners was adopted by the CRLA board in 2002 and published with a theoretical rationale in ["Journal of College Reading and Learning"] "JCRL," Spring 2003. The statement was a guideline for educators seeking to improve the quality of adult education. In 2016, at the…

  2. Communication: Learning to Write for the Reader.

    Todd, Mavis M.


    A new approach to teaching students to write effective business letters is presented. It uses class members as resources, writers, and readers for the assignment. Four stages are described: the interview, discussion of models and format, revision, and the reply. Results of the exercise and suggestions for continued application are included. (CT)

  3. A digital reader for condenser ionization chambers

    Stuermer, K.


    A reader for condenser chambers is described which has a completely automatic reading/charging operation, a modern digital readout presentation, and two full decades of exposure readout for each dosimeter type. The calibration and operation of the instrument are given

  4. Satisfying the Needs of the Serious Reader.

    Hopkins, Richard


    An examination of how well the Canadian public library is meeting the needs of the serious reader interested in self education, as compared to new and secondhand book stores and academic libraries, found that the public library is the most important and effective agency in providing materials for this group. (CLB)

  5. Patterns of Analogical Reasoning among Beginning Readers

    Farrington-Flint, Lee; Wood, Clare; Canobi, Katherine H.; Faulkner, Dorothy


    Despite compelling evidence that analogy skills are available to beginning readers, few studies have actually explored the possibility of identifying individual differences in young children's analogy skills in early reading. The present study examined individual differences in children's use of orthographic and phonological relations between…

  6. Collaboration between SSMJ and its readers

    All of us in the healthcare professions throughout the world can learn much from each other. This has been demonstrated so well by the collaboration between the editors, authors, medical experts and readers of the South Sudan Medical Journal. The Editor-in-Chief recently sent out a request for photographs and received a ...

  7. Readers' Tellings: Narrators, Settings, Flashbacks and Comprehension

    Kucer, Stephen B.


    This research explores the impact of flashbacks and changes in settings and narrators on reader comprehension. Individually, 34 fourth graders (9 and 10 years of age), mostly with above average reading abilities (5.0), orally read the first chapter of a novel. Both publisher and readability formulae estimated the text to be at a fourth- grade…

  8. Next Generation Model 8800 Automatic TLD Reader

    Velbeck, K.J.; Streetz, K.L.; Rotunda, J.E.


    BICRON NE has developed an advanced version of the Model 8800 Automatic TLD Reader. Improvements in the reader include a Windows NT TM -based operating system and a Pentium microprocessor for the host controller, a servo-controlled transport, a VGA display, mouse control, and modular assembly. This high capacity reader will automatically read fourteen hundred TLD Cards in one loading. Up to four elements in a card can be heated without mechanical contact, using hot nitrogen gas. Improvements in performance include an increased throughput rate and more precise card positioning. Operation is simplified through easy-to-read Windows-type screens. Glow curves are displayed graphically along with light intensity, temperature, and channel scaling. Maintenance and diagnostic aids are included for easier troubleshooting. A click of a mouse will command actions that are displayed in easy-to-understand English words. Available options include an internal 90 Sr irradiator, automatic TLD calibration, and two different extremity monitoring modes. Results from testing include reproducibility, reader stability, linearity, detection threshold, residue, primary power supply voltage and frequency, transient voltage, drop testing, and light leakage. (author)

  9. Meeting the Needs of Struggling Adolescent Readers

    Stover, Katie; O'Rear, Allison; Morris, Carolyn


    Research suggests that additional reading instruction is necessary to support struggling adolescent readers. In addition to time allocated for reading and access to appropriately leveled texts, many students need teacher support in learning and implementing a range of reading strategies. As a high school English teacher and a middle school Social…

  10. Shakespeare and Reader's Theatre: Fellow Traveling Companions

    Ratliff, Gerald Lee


    Whether constructed on literary analysis models or inspired by conventional acting theories, Reader's Theatre performance techniques are an invaluable instructional tool available to teachers who want their students to see, hear and feel Shakespeare texts in classroom discussion and performance. These exercises are designed to promote both a…

  11. Understanding Deaf Readers: An Interpretative Phenomenological Analysis

    Kelstone, Aaron Weir


    The development of reading skills, beyond a functional level, is difficult for most deaf readers. Standardized testing demonstrates a median 4th grade reading level that remains consistent even after national norming of the Stanford Achievement test on the population of deaf school children. Deaf education continues to generate various educational…

  12. The Emergent Reader's Working Kit of Stereotypes

    Mackey, Margaret


    This article draws on a careful study of series fiction read in the 1950s to explore how stereotypes feature in the development of a young reader's competence in learning to process stories in print. Five categories of stereotype are teased out: "embodied stereotypes," understood through physical experience; "working stereotypes," discerned…

  13. Guiding Young Readers to Multicultural Literature

    Hinton-Johnson, KaaVonia; Dickinson, Gail


    Stocking the shelves of library media centers with multicultural literature is not enough, it is important that children are helped to choose the ones that would interest them as reading about various cultures is of great benefit to young readers. The importance of accurately representing to children a multicultural society is emphasized and…

  14. Lexical Reading in Dysfluent Readers of German

    Gangl, Melanie; Moll, Kristina; Jones, Manon W.; Banfi, Chiara; Schulte-Körne, Gerd; Landerl, Karin


    Dyslexia in consistent orthographies like German is characterized by dysfluent reading, which is often assumed to result from failure to build up an orthographic lexicon and overreliance on decoding. However, earlier evidence indicates effects of lexical processing at least in some German dyslexic readers. We investigated variations in reading…

  15. Readerly and Writerly "Letters from the Park."

    Conde, Susana


    Discusses in depth the film "Cartas del parque" ("Letters from the Park"), the first of six films in the "Amores Dificiles" series. Notes that the film is pervaded by the traditional overdetermination of gender roles. Suggests that an intrusive and authoritative narrator makes of this both a "readerly" and a…

  16. Trade Related Reading Packets for Disabled Readers.

    Davis, Beverly; Woodruff, Nancy S.

    Six trade-related reading packets for disabled readers are provided for these trades: assemblers, baking, building maintenance, data entry, interior landscaping, and warehousing. Each packet stresses from 9 to 14 skills. Those skills common to most packets include context clues, fact or opinion, details, following directions, main idea,…

  17. Exhaled breath condensate pH does not discriminate asymptomatic gastroesophageal reflux or the response to lansoprazole treatment in children with poorly controlled asthma.

    Fitzpatrick, Anne M; Holbrook, Janet T; Wei, Christine Y; Brown, Meredith S; Wise, Robert A; Teague, W Gerald


    Although exhaled breath condensate (EBC) pH has been identified as an "emerging" biomarker of interest for asthma clinical trials, the clinical determinants of EBC pH remain poorly understood. Other studies have associated acid reflux-induced respiratory symptoms, for example, cough, with transient acidification of EBC. We sought to determine the clinical and physiologic correlates of EBC acidification in a highly characterized sample of children with poorly controlled asthma. We hypothesized that (1) children with asymptomatic gastroesophageal reflux determined by 24-hour esophageal pH monitoring would have a lower EBC pH than children without gastroesophageal reflux, (2) treatment with lansoprazole would alter EBC pH in those children, and (3) EBC acidification would be associated with increased asthma symptoms, poorer asthma control and quality of life, and increased formation of breath nitrogen oxides (NOx). A total of 110 children, age range 6 to 17 years, with poor asthma control and esophageal pH data enrolled in the Study of Acid Reflux in Children with Asthma (NCT00442013) were included. Children submitted EBC samples for pH and NOx measurement at randomization and at study weeks 8, 16, and 24. Serial EBC pH measurements failed to distinguish asymptomatic gastroesophageal reflux and was not associated with breath NOx formation. EBC pH also did not discriminate asthma characteristics such as medication and health care utilization, pulmonary function, and asthma control and quality of life both at baseline and across the study period. Despite the relative ease of EBC collection, EBC pH as a biomarker does not provide useful information of children with asthma who were enrolled in asthma clinical trials. Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  18. Systematical and statistical errors in using reference light sources to calibrate TLD readers

    Burgkhardt, B.; Piesch, E.


    Three light sources, namely an NaI(Tl) scintillator + Ra, an NaI(Tl) scintillator + 14 C and a plastic scintillator + 14 C, were used during a period of 24 months for a daily check of two TLD readers: the Harshaw 2000 A + B and the Toledo 651. On the basis of light source measurements long-term changes and day-to-day fluctuations of the reader response were investigated. Systematical changes of the Toledo reader response of up to 6% during a working week are explained by nitrogen effects in the plastic scintillator light source. It was found that the temperature coefficient of the light source intensity was -0.05%/ 0 C for the plastic scintillator and -0.3%/ 0 C for the NaI(Tl) scintillator. The 210 Pb content in the Ra activated NaI(Tl) scintillator caused a time-dependent decrease in light source intensity of 3%/yr for the light source in the Harshaw reader. The internal light sources revealed a relative standard deviation of 0.5% for the Toledo reader and the Harshaw reader after respective reading times of 0.45 and 100 sec. (author)

  19. Minimal stimulation protocol using letrozole versus microdose flare up GnRH agonist protocol in women with poor ovarian response undergoing ICSI.

    Mohsen, Iman Abdel; El Din, Rasha Ezz


    To compare the IVF outcomes of letrozole/antagonist and microdose GnRH agonist flare up protocols in poor ovarian responders undergoing intracytoplasmic sperm injection. A randomized controlled trial was performed in patients with one or more previous failed IVF cycles in which four or less oocytes were retrieved when the gonadotrophin starting dose was at least 300 IU/day. Sixty patients were randomized by computer-generated list to receive either letrozole/antagonist (mild stimulation) n = 30 or GnRH-a protocol (microdose flare) n = 30. Both groups were similar with respect to background and hormonal characteristics (age, duration of infertility, BMI, FSH, LH and E2). The clinical pregnancy rate per cycle was similar in both groups (13.3 vs. 16.6%; OR = 0.769; 95% CI = 0.185, 3.198). The doses of used gonadotropins and the number of stimulation days were significantly lower in the letrozole/antagonist protocol. The peak E2 level on the day of hCG, the endometrial thickness, the retrieved oocytes, the number of fertilized oocytes, the number of transferred embryos and the cancellation rate were statistically similar in both groups. The letrozole/antagonist protocol is a cost-effective and patient-friendly protocol that may be used in poor ovarian responders for IVF/ICSI.

  20. Inference in `poor` languages

    Petrov, S.


    Languages with a solvable implication problem but without complete and consistent systems of inference rules (`poor` languages) are considered. The problem of existence of finite complete and consistent inference rule system for a ``poor`` language is stated independently of the language or rules syntax. Several properties of the problem arc proved. An application of results to the language of join dependencies is given.

  1. High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer

    Rasmussen, Mads Heilskov; Jensen, Niels; Tarpgaard, Line Schmidt


    The backbone of current cytotoxic treatment of metastatic colorectal cancer (mCRC) consists of a fluoropyrimidine together with either oxaliplatin (XELOX/FOLFOX) or irinotecan (XELIRI/FOLFIRI). With an overall objective response rate of approximately 50% for either treatment combination, a major...... analyses showed that miR-625-3p was not dysregulated between normal and cancer samples, nor was its expression associated with recurrence of stage II or III disease, indicating that miR-625-3p solely is a response marker. Finally, we also found that these miRNAs were up-regulated in oxaliplatin resistant...... unsolved problem is that no predictors of response to these treatments are available. To address this issue, we profiled 742 microRNAs in laser-capture microdissected cancer cells from responding and non-responding patients receiving XELOX/FOLFOX as first-line treatment for mCRC, and identified, among...

  2. Blind Braille readers mislocate tactile stimuli.

    Sterr, Annette; Green, Lisa; Elbert, Thomas


    In a previous experiment, we observed that blind Braille readers produce errors when asked to identify on which finger of one hand a light tactile stimulus had occurred. With the present study, we aimed to specify the characteristics of this perceptual error in blind and sighted participants. The experiment confirmed that blind Braille readers mislocalised tactile stimuli more often than sighted controls, and that the localisation errors occurred significantly more often at the right reading hand than at the non-reading hand. Most importantly, we discovered that the reading fingers showed the smallest error frequency, but the highest rate of stimulus attribution. The dissociation of perceiving and locating tactile stimuli in the blind suggests altered tactile information processing. Neuroplasticity, changes in tactile attention mechanisms as well as the idea that blind persons may employ different strategies for tactile exploration and object localisation are discussed as possible explanations for the results obtained.

  3. The automated Risoe TL dating reader system

    Boetter-Jensen, L.


    The features of the new modified Riso TL dating reader system are described. A vacuum chamber that accommodates the entire 24-position sample changer unit has been designed. The vacuum and N 2 -gas functions are software-controlled. A newly designed heater system is capable of repeated heating cycles to 700 0 C. The sample changer system accommodates fine-grain discs as well as planchettes for coarse grains. Two software-controlled beta irradiators can be attached to the reader, e.g. for predose measurement. The software allows a user without programming expertise to create any desired measuring sequence, and to store and recall data and glow curves for making analyses. (author)

  4. Improvements of RGD3 TLD reader

    Zhao Jianxing; Wang Jiaqi; Li Yuanfang; Wu Furong; Xiao Wuyun


    The author summarized the main features of the improved RGD3 TLD reader. Through a large number of experiments some persuasive data are obtained, which show that an remarkable improvement has been achieved, especially in its stability to the standard illuminates, data dispersivity, and effectiveness to glow curves analysis. Working with the newly developed data processing software, the comprehensive performance of the whole system will be enhanced greatly

  5. The StorySpinner Sculptural Reader

    Hooper, Clare; Weal, Mark


    This demo is of a hypertext reading system called StorySpinner. It follows the sculptural hypertext methodology and has been used as a test bed for experimenting with the authoring of narrative flow in automatically generated stories. Readers are able to select and read one of two available stories. Reading a story involves selecting tarot cards which are mapped to chunks of story text based on possible interpretations of the cards and information concerning current story state.

  6. Plastic Logic quits e-reader market

    Perks, Simon


    A UK firm spun out from the University of Cambridge that sought to be a world leader in flexible organic electronic circuits and displays has pulled out of the competitive e-reader market as it struggles to find a commercial outlet for its technology. Plastic Logic announced in May that it is to close its development facility in Mountain View, California, with the loss of around 40 jobs.

  7. Microcomputer control of automated TLD reader

    Bjarland, Bert.


    The interfacing electronics, the control algorithms and the developed programs of a 6800 microcomputer controlled automated TLD reader are described. The TL reading system is implemented with a photomultiplier tube and a charge-to-pulse converter. The gain of the TL reading system is controlled through the use of a temperature compensated LED reference light source. Automatic compensation of PM tube dark current is optional. The short term stability of TL readings is better than 3 %. (author)

  8. Movie reviews: Who are the readers?

    Jose Ignacio Azuela Flores; Victor Fernandez-Blanco; Maria Jose Sanzo-Perez


    The analysis of the relationship between movie reviews and consumer's decision process has focused mainly on the side of critics, who have been defined as "influencers" or as "predictors" (Eliashberg & Shugan, 1997). Also, new ways to measure the impact of the critic have been introduced (Gemser, van Oostrum & Leenders, 2007) and the consistency of their opinions over time has been proved (Ginsburgh & Weyers, 1999). However, there is scarce evidence about the readers of movie reviews: who are...

  9. Tactile spatial resolution in blind braille readers.

    Van Boven, R W; Hamilton, R H; Kauffman, T; Keenan, J P; Pascual-Leone, A


    To determine if blind people have heightened tactile spatial acuity. Recently, studies using magnetic source imaging and somatosensory evoked potentials have shown that the cortical representation of the reading fingers of blind Braille readers is expanded compared to that of fingers of sighted subjects. Furthermore, the visual cortex is activated during certain tactile tasks in blind subjects but not sighted subjects. The authors hypothesized that the expanded cortical representation of fingers used in Braille reading may reflect an enhanced fidelity in the neural transmission of spatial details of a stimulus. If so, the quantitative limit of spatial acuity would be superior in blind people. The authors employed a grating orientation discrimination task in which threshold performance is accounted for by the spatial resolution limits of the neural image evoked by a stimulus. The authors quantified the psychophysical limits of spatial acuity at the middle and index fingers of 15 blind Braille readers and 15 sighted control subjects. The mean grating orientation threshold was significantly (p = 0.03) lower in the blind group (1.04 mm) compared to the sighted group (1.46 mm). The self-reported dominant reading finger in blind subjects had a mean grating orientation threshold of 0.80 mm, which was significantly better than other fingers tested. Thresholds at non-Braille reading fingers in blind subjects averaged 1.12 mm, which were also superior to sighted subjects' performances. Superior tactile spatial acuity in blind Braille readers may represent an adaptive, behavioral correlate of cortical plasticity.

  10. Exploiting the Poor

    Kamp Justesen, Mogens; Bjørnskov, Christian


    While extant research has focused on the causes and consequences of corruption at the macro-level, less effort has been devoted to understanding the micro-foundation of corruption. We argue that poor people are more likely to be victims of corrupt behavior by street-level bureaucrats as the poor...... often rely heavily on services provided by governments. We test this proposition using micro-level survey data from the Afrobaromenter. Multilevel regressions across 18 countries show that poor people are much more prone to experience having to pay bribes to government officials....

  11. Expression of DNA Damage Response Molecules PARP1, γH2AX, BRCA1, and BRCA2 Predicts Poor Survival of Breast Carcinoma Patients

    See-Hyoung Park


    Full Text Available BACKGROUND: Poly(ADP-ribose polymerase 1 (PARP1, γH2AX, BRCA1, and BRCA2 are conventional molecular indicators of DNA damage in cells and are often overexpressed in various cancers. In this study, we aimed, using immunohistochemical detection, whether the co-expression of PARP1, γH2AX, BRCA1, and BRCA2 in breast carcinoma (BCA tissue can provide more reliable prediction of survival of BCA patients. MATERIALS AND METHODS: We investigated immunohistochemical expression and prognostic significance of the expression of PARP1, γH2AX, BRCA1, and BRCA2 in 192 cases of BCAs. RESULTS: The expression of these four molecules predicted earlier distant metastatic relapse, shorter overall survival (OS, and relapse-free survival (RFS by univariate analysis. Multivariate analysis revealed the expression of PARP1, γH2AX, and BRCA2 as independent poor prognostic indicators of OS and RFS. In addition, the combined expressional pattern of BRCA1, BRCA2, PARP1, and γH2AX (CSbbph was an additional independent prognostic predictor for OS (P < .001 and RFS (P < .001. The 10-year OS rate was 95% in the CSbbph-low (CSbbph scores 0 and 1 subgroup, but that was only 35% in the CSbbph-high (CSbbph score 4 subgroup. CONCLUSION: This study has demonstrated that the individual and combined expression patterns of PARP1, γH2AX, BRCA1, and BRCA2 could be helpful in determining an accurate prognosis for BCA patients and for the selection of BCA patients who could potentially benefit from anti-PARP1 therapy with a combination of genotoxic chemotherapeutic agents.

  12. Poor response cycles: when should we cancel? Comparison of outcome between egg collection, intrauterine insemination conversion, and follow-up cycles after abandonment.

    Nicopoullos, James D M; Abdalla, Hossam


    To determine optimal management with one or two mature follicles after stimulation. Retrospective analysis. Lister fertility clinic. A total of 1,350 IVF/intracytoplasmic sperm injection cycles (7.3% of total) during 1998-2009 were found to have one or two mature follicles. Group 1 (n = 807) comprised those who proceeded to vaginal egg collection (VEC) (59.8%; outcome per egg collection), group 2 (n=248) those who converted to IUI (18.4%; outcome per insemination) and group 3 (n=259) those who abandoned the current cycle (21.9%; outcome per abandoned cycle in first subsequent cycle). Live birth rate, clinical pregnancy rate, and biochemical pregnancy rate. Biochemical pregnancy rates of 13.1%, 4.9%, and 9.7%, clinical pregnancy rates of 8.1%, 3.6%, and 7.2%, and ongoing pregnancy rates of 6.8%, 2.0%, and 5.5% were achieved in groups 1, 2, and 3, respectively. All pregnancy outcomes were significantly higher after VEC (group 1) than for those converted to IUI (group 2), and all pregnancy outcomes were higher with borderline significance in group 3 vs. group 2. There was no significant difference in outcome between groups 1 and 3. Our data suggest that for such poor responders, proceeding to VEC may represent their best chance of successful outcome. Conversion to IUI offers the poorest outcome, and despite the potential for improvements in cycle protocol, abandoning and a further attempt does not improve outcome (using abandoned cycle as the denominator). Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  13. Accounting for the Poor

    Robert M. Townsend


    Economists and other social scientists have long tried to understand the nature of poverty and how poor people make decisions. For example, T.W. Schultz, a Nobel Laureate, former professor of economics at the University of Chicago, and former president of the American Economic Association, spent his career working in development and agricultural economics. In his 1980 Nobel Prize acceptance speech, Schultz suggests that there is some accounting for the behavior of the poor in agriculture. "Fa...

  14. Poor sensitization of 50-kHz vocalization response to amphetamine predicts rat susceptibility to self-administration of the drug

    Taracha, Ewa; Kaniuga, Ewelina; Wyszogrodzka, Edyta; P?a?nik, Adam; Stefa?ski, Roman; Chrapusta, Stanis?aw J.


    Rationale Our previous studies showed promise for using sensitization of the frequency-modulated 50-kHz vocalization response to amphetamine (AMPH) as an index of rat vulnerability to AMPH addiction. Objective This study aimed to test the utility of sensitizing frequency-modulated (FM) 50-kHz vocalization in the AMPH self-administration paradigm as well as the ability of N-acetylcysteine to prevent self-administration relapse. Methods Rats were subjected to the so-called two-injection protoco...

  15. 21 CFR 886.5800 - Ophthalmic bar reader.


    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ophthalmic bar reader. 886.5800 Section 886.5800...) MEDICAL DEVICES OPHTHALMIC DEVICES Therapeutic Devices § 886.5800 Ophthalmic bar reader. (a) Identification. An ophthalmic bar reader is a device that consists of a magnifying lens intended for use by a...

  16. Rereading Multicultural Readers: What Definition of Multicultural Are We Buying?

    Shapiro, Nancy

    A flood of new multicultural readers and textbooks are hitting the market for writing and literature courses at the college level. Yet there has been no systematic examination of how these readers are being used, the purposes and audiences for which they are written, or the critical reception they have received. Multicultural readers distinguish…

  17. Choosing the Adequate Level of Graded Readers--Preliminary Study

    Prtljaga, Jelena; Palinkaševic, Radmila; Brkic, Jovana


    Graded readers have been used as second language teaching material since the end of the Second World War. They are an important source of simplified material which provides comprehensible input on all levels. It is of crucial importance for a successful usage of graded readers in the classroom and in studies which focus on graded readers, that an…

  18. Gifted Male Readers: Current Understandings and Suggestions for Future Research

    Pagnani, Alexander R.


    Research literature concerning gifted male readers relies primarily on more extensive bodies of work regarding gifted males and male readers. Studied as a whole, the two halves portray a worrisome state of affairs for gifted male readers, who lag behind their female counterparts in the same patterns found across the ability spectrum. This literacy…

  19. Reader Engagement in English and Persian Applied Linguistics Articles

    Ansarin, Ali Akbar; Tarlani-Aliabdi, Hassan


    There is an increasing interest in the way academic writers establish the presence of their readers over the past few years. Establishing the presence of readers or what Kroll (1984, p.181) calls imagining "a second voice" is accomplished when a writer refers "explicitly" to their readers using explicit linguistic resources…

  20. Reading and Spelling Error Analysis of Native Arabic Dyslexic Readers

    Abu-rabia, Salim; Taha, Haitham


    This study was an investigation of reading and spelling errors of dyslexic Arabic readers ("n"=20) compared with two groups of normal readers: a young readers group, matched with the dyslexics by reading level ("n"=20) and an age-matched group ("n"=20). They were tested on reading and spelling of texts, isolated…

  1. Clot lysis time in platelet-rich plasma: method assessment, comparison with assays in platelet-free and platelet-poor plasmas, and response to tranexamic acid.

    Panes, Olga; Padilla, Oslando; Matus, Valeria; Sáez, Claudia G; Berkovits, Alejandro; Pereira, Jaime; Mezzano, Diego


    Fibrinolysis dysfunctions cause bleeding or predisposition to thrombosis. Platelets contain several factors of the fibrinolytic system, which could up or down regulate this process. However, the temporal relationship and relative contributions of plasma and platelet components in clot lysis are mostly unknown. We developed a clot lysis time (CLT) assay in platelet-rich plasma (PRP-CLT, with and without stimulation) and compared it to a similar one in platelet-free plasma (PFP) and to another previously reported test in platelet-poor plasma (PPP). We also studied the differential effects of a single dose of tranexamic acid (TXA) on these tests in healthy subjects. PFP- and PPP-CLT were significantly shorter than PRP-CLT, and the three assays were highly correlated (p plasma PAI-1, von Willebrand factor, fibrinogen, LDL-cholesterol, and triglycerides (p platelet aggregation/secretion, platelet counts, and pro-coagulant tests to explore factor X activation by platelets, PRP clotting time, and thrombin generation in PRP. Among all the studied variables, PFP-CLT was independently associated with plasma PAI-1, LDL-cholesterol, and triglycerides and, additionally, stimulated PRP-CLT was also independently associated with plasma fibrinogen. A single 1 g dose of TXA strikingly prolonged all three CLTs, but in contrast to the results without the drug, the lysis times were substantially shorter in non-stimulated or stimulated PRP than in PFP and PPP. This standardized PRP-CLT may become a useful tool to study the role of platelets in clot resistance and lysis. Our results suggest that initially, the platelets enmeshed in the clot slow down the fibrinolysis process. However, the increased clot resistance to lysis induced by TXA is overcome earlier in platelet-rich clots than in PFP or PPP clots. This is likely explained by the display of platelet pro-fibrinolytic effects. Focused research is needed to disclose the mechanisms for the relationship between CLT and plasma

  2. Short-term combined treatment with liraglutide and metformin leads to significant weight loss in obese women with polycystic ovary syndrome and previous poor response to metformin.

    Jensterle Sever, Mojca; Kocjan, Tomaz; Pfeifer, Marija; Kravos, Nika Aleksandra; Janez, Andrej


    The effect of metformin on weight reduction in polycystic ovary syndrome (PCOS) is often unsatisfactory. In this study, we investigated the potential add-on effect of treatment with the glucagon-like peptide-1 receptor agonist liraglutide on weight loss in obese nondiabetic women with PCOS who had lost weight during pretreatment with metformin. A total of 40 obese women with PCOS, who had been pretreated with metformin for at least 6 months, participated in a 12-week open-label, prospective study. They were randomized to one of three treatment arms: metformin (MET) arm 1000 mg BID, liraglutide (LIRA) arm 1.2 mg QD s.c., or combined MET 1000 mg BID and LIRA (COMBI) 1.2 mg QD s.c. Lifestyle intervention was not actively promoted. The primary outcome was change in body weight. Thirty six patients (aged 31.3 ± 7.1 years, BMI 37.1 ± 4.6 kg/m²) completed the study: 14 on MET, 11 on LIRA, and 11 on combined treatment. COMBI therapy was superior to LIRA and MET monotherapy in reducing weight, BMI, and waist circumference. Subjects treated with COMBI lost on average 6.5 ± 2.8 kg compared with a 3.8 ± 3.7 kg loss in the LIRA group and a 1.2 ± 1.4 kg loss in the MET group (Pweight loss was stratified: a total of 38% of subjects were high responders who lost ≥5% body weight, 22% of them in the COMBI arm compared with 16 and 0% in the LIRA and MET arm respectively. BMI decreased by 2.4 ± 1.0 in the COMBI arm compared with 1.3 ± 1.3 in LIRA and 0.5 ± 0.5 in the MET arm (Pweight loss. Short-term combined treatment with liraglutide and metformin was associated with significant weight loss and decrease in waist circumference in obese women with PCOS who had previously been poor responders regarding weight reduction on metformin monotherapy.

  3. An increased rectal maximum tolerable volume and long anal canal are associated with poor short-term response to biofeedback therapy for patients with anismus with decreased bowel frequency and normal colonic transit time.

    Rhee, P L; Choi, M S; Kim, Y H; Son, H J; Kim, J J; Koh, K C; Paik, S W; Rhee, J C; Choi, K W


    Biofeedback is an effective therapy for a majority of patients with anismus. However, a significant proportion of patients still failed to respond to biofeedback, and little has been known about the factors that predict response to biofeedback. We evaluated the factors associated with poor response to biofeedback. Biofeedback therapy was offered to 45 patients with anismus with decreased bowel frequency (less than three times per week) and normal colonic transit time. Any differences in demographics, symptoms, and parameters of anorectal physiologic tests were sought between responders (in whom bowel frequency increased up to three times or more per week after biofeedback) and nonresponders (in whom bowel frequency remained less than three times per week). Thirty-one patients (68.9 percent) responded to biofeedback and 14 patients (31.1 percent) did not. Anal canal length was longer in nonresponders than in responders (4.53 +/- 0.5 vs. 4.08 +/- 0.56 cm; P = 0.02), and rectal maximum tolerable volume was larger in nonresponders than in responders. (361 +/- 87 vs. 302 +/- 69 ml; P = 0.02). Anal canal length and rectal maximum tolerable volume showed significant differences between responders and nonresponders on multivariate analysis (P = 0.027 and P = 0.034, respectively). This study showed that a long anal canal and increased rectal maximum tolerable volume are associated with poor short-term response to biofeedback for patients with anismus with decreased bowel frequency and normal colonic transit time.

  4. How to diagnose any type of TLD Reader?; Como diagnosticar cualquier tipo de TLD Reader?

    Rodriguez, Manuel Lopez; Garcia, Jose A. Tamayo; Gil, Alex Vergara; Lores, Stefan Gutierrez; Acosta, Andry Romero; Villanueva, Gilberto Alonso, E-mail:, E-mail:, E-mail:, E-mail:, E-mail:, E-mail: [Centro de Proteccion e Higiene de las Radiaciones (CPHR), La Habana (Cuba)


    The acquisition of know how of practical experiences obtained in the repair and maintenance of readers TLD RADOS for five years of work and the request by the International Atomic Energy for signing new Research Contracts (CRP), made possible the CRP 13328, in which the specialist is committed in the course of a year, to deliver educational software in order to train personnel associated with the operation of the TLD readers RADOS. Due to the importance of continuous transfer of knowledge for new generations of technicians and specialists who join our laboratories, the idea came when the first interactive CD that grouped 19 videos, divided into three blocks was ready: learning, repair and maintenance; it was suggested to expand the training for any TLD reader. Thus a much more complete than the first version package emerged. 7 cases were subsequently published in an IAEA TECDOC, 1599 were included.

  5. Techno-Literacy Practices of Emergent Readers

    Razeale G. Fernandez


    Full Text Available – This research explored the techno-literacy practices of emergent readers. The study found that young children experienced a multi-literate practices in their homes that comprised not only print and paper-based literacies but also techno-literacies. That television, games on tablets and phones are the sources of textual pleasure of young children.Families reported that children watched television and play games on tablets/phones regularly. This is due to the limited options of leisure activities available to younger children. Emergent readers are highly focused to televisual text as they demonstrate meaningmaking practices when they constantly ask questions and talk about what they are watching,hence they are active meaning-makers. The learning opportunities which include hand eye coordination, parallel processing, and problem solving skills young children acquired through playing computer games and games on tablet/iPad . Aside from these, they also developed a number of literacy skills as well as how to behave as players.It can be concluded thatexposure to imagery in electronic technologies contributed to the children’s literacy development. The literate identities of emergent readers can be further enhanced as they begin formal schooling. Data indicated that young children are developing techno-literacy practices and this concurs to the findings of Marsh (2010. Therefore, technology serves as a tool for the literacy development of young children. That techno-literacy practices of young children should be valued in school. Future research should also consider attitude, behavior and practices of parents towards the use of technology by children.

  6. Baseline β-catenin, programmed death-ligand 1 expression and tumour-infiltrating lymphocytes predict response and poor prognosis in BRAF inhibitor-treated melanoma patients.

    Massi, Daniela; Romano, Emanuela; Rulli, Eliana; Merelli, Barbara; Nassini, Romina; De Logu, Francesco; Bieche, Ivan; Baroni, Gianna; Cattaneo, Laura; Xue, Gongda; Mandalà, Mario


    The activation of oncogenic Wnt/β-catenin pathway in melanoma contributes to a lack of T-cell infiltration. Whether baseline β-catenin expression in the context of tumour-infiltrating lymphocytes (TILs) and programmed death ligand-1 (PD-L1) overexpression correlates with prognosis of metastatic melanoma patients (MMPs) treated with mitogen-activated protein kinase, MAPK inhibitor (MAPKi) monotherapy, however, has not been fully clarified. Sixty-four pre-treatment formalin-fixed and paraffin embedded melanoma samples from MMP treated with a BRAF inhibitor (n = 39) or BRAF and MEK inhibitors (n = 25) were assessed for presence of β-catenin, PD-L1, cluster of differentiation (CD)8, CD103 and forkhead box protein P3 (FOXP3) expression by immunohistochemistry, and results were correlated with clinical outcome. Quantitative assessment of mRNA transcripts associated with Wnt/β-catenin pathway and immune response was performed in 51 patients. We found an inverse correlation between tumoural β-catenin expression and the level of CD8, CD103 or forkhead box protein P3 (FOXP3) positivity in the tumour microenvironment (TME). By multivariate analysis, PD-L1 <5% (odds ratio, OR 0.12, 95% confidence interval, CI 0.03-0.53, p = 0.005) and the presence of CD8+ T cells (OR 18.27, 95%CI 2.54-131.52, p = 0.004) were significantly associated with a higher probability of response to MAPKi monotherapy. Responding patients showed a significantly increased expression of mRNA transcripts associated with adaptive immunity and antigen presentation. By multivariate analysis, progression-free survival (PFS) (hazards ratio (HR) = 0.25 95%CI 0.10-0.61, p = 0.002) and overall survival (OS) (HR = 0.24 95%CI 0.09-0.67, p = 0.006) were longer in patients with high density of CD8+ T cells and β-catenin <10% than those without CD8+ T cells infiltration and β-catenin ≥10%. Our findings provide evidence that in the context of MAPKi monotherapy, immune subsets in the (TME) and

  7. Face-to-face with the reader

    Thomas SCHMITZ


    Full Text Available From the scientific perspective this review is very interesting. It is well-structured, has an attractive lay-out and typography and serves as an important forum for the scientific debate on public administration in the Republic of Moldova. Furthermore, there is a special website with several subwebsites for the review. This makes it easy for every interested reader to get an idea of the review. Finally, the websites allows free downloads even of the newest issue. This allows everybody to read it, even students (because it is free and foreign researchers (who otherwise would not have access to Moldovan scientific reviews.

  8. PC-based car license plate reader

    Hwang, Chung-Mu; Shu, Shyh-Yeong; Chen, Wen-Yu; Chen, Yie-Wern; Wen, Kuang-Pu


    A car license plate reader (CLPR) using fuzzy inference and neural network algorithm has been developed in Industrial Technology Research Institute (ITRI) and installed in highway toll stations to identify stolen cars. It takes an average of 0.7 seconds to recognize a car license plate by using a PC with 80486-50 CPU. The recognition rate of the system is about 97%. The techniques of CLPR include vehicle sensing, image grab control, optic pre- processing, lighting, and optic character recognition (OCR). The CLPR can be used in vehicle flow statistics, the checking of stolen vehicles, automatic charging systems in parking lots or garage management, and so on.

  9. BOOK REVIEW: Astrophysics (Advanced Physics Readers)

    Kibble, Bob


    Here is a handy and attractive reader to support students on post-16 courses. It covers the astrophysics, astronomy and cosmology that are demanded at A-level and offers anyone interested in these fields an interesting and engaging reference book. The author and the production team deserve credit for producing such an attractive book. The content, in ten chapters, covers what one would expect at this level but it is how it is presented that struck me as the book's most powerful asset. Each chapter ends with a summary of key ideas. Line drawings are clear and convey enough information to make them more than illustrations - they are as valuable as the text in conveying information. Full colour is used throughout to enhance illustrations and tables and to lift key sections of the text. A number of colour photographs complement the material and serve to maintain interest and remind readers that astrophysics is about real observable phenomena. Included towards the end is a set of tables offering information on physical and astronomical data, mathematical techniques and constellation names and abbreviations. This last table puzzled me as to its value. There is a helpful bibliography which includes society contacts and a website related to the text. Perhaps my one regret is that there is no section where students are encouraged to actually do some real astronomy. Astrophysics is in danger of becoming an armchair and calculator interest. There are practical projects that students could undertake either for school assessment or for personal interest. Simple astrophotography to capture star trails, observe star colours and estimate apparent magnitudes is an example, as is a simple double-star search. There are dozens more. However, the author's style is friendly and collaborative. He befriends the reader as they journey together through the ideas. There are progress questions at the end of each chapter. Their style tends to be rather closed and they emphasize factual recall

  10. Lower education predicts poor response to dietary intervention in pregnancy, regardless of neighbourhood affluence: secondary analysis from the ROLO randomised control trial.

    O'Brien, Eileen C; Alberdi, Goiuri; Geraghty, Aisling A; McAuliffe, Fionnuala M


    To determine if response to a low glycaemic index (GI) dietary intervention, measured by changes in dietary intake and gestational weight gain, differed across women of varying socio-economic status (SES). Secondary data analysis of the ROLO randomised control trial. The intervention consisted of a two-hour low-GI dietary education session in early pregnancy. Change in GI was measured using 3 d food diaries pre- and post-intervention. Gestational weight gain was categorised as per the 2009 Institute of Medicine guidelines. SES was measured using education and neighbourhood deprivation. The National Maternity Hospital, Dublin, Ireland. Women (n 625) recruited to the ROLO randomised control trial. The intervention significantly reduced GI and excess gestational weight gain (EGWG) among women with third level education residing in both disadvantaged (GI, mean (sd), intervention v. control: -3·30 (5·15) v. -0·32 (4·22), P=0·024; EGWG, n (%), intervention v. control: 7 (33·6) v. 22 (67·9); P=0·022) and advantaged areas (GI: -1·13 (3·88) v. 0·06 (3·75), P=0·020; EGWG: 41 (34·1) v. 58 (52·6); P=0·006). Neither GI nor gestational weight gain differed between the intervention and control group among women with less than third level education, regardless of neighbourhood deprivation. A single dietary education session was not effective in reducing GI or gestational weight gain among less educated women. Multifaceted, appropriate and practical approaches are required in pregnancy interventions to improve pregnancy outcomes for less educated women.

  11. 9. Poor medication


    Majority (60%) of the patients were reviewed at least twice in the last 6 months at the time of the interview. 195 (83%) patients reported that drugs prescribed were not available at the hospital pharmacy, but 186 (79%) of. Factors Associated With Poor Medication Adherence. In Hypertensive Patients In Lusaka, Zambia. 1,4. 1.

  12. Automatic spent fuel ID number reader (I)

    Tanabe, S.; Kawamoto, H.; Fujimaki, K.; Kobe, A.


    An effective and efficient technique has been developed for facilitating identification works of LWR spent fuel stored in large scale spent fuel storage pools of such as processing plants. Experience shows that there are often difficulties in the implementation of operator's nuclear material accountancy and control works as well as safeguards inspections conducted on spent fuel assemblies stored in deep water pool. This paper reports that the technique is realized as an automatic spent fuel ID number reader system installed on fuel handling machine. The ID number reader system consists of an optical sub-system and an image processing sub-system. Thousands of spent fuel assemblies stored in under water open racks in each storage pool could be identified within relatively short time (e.g. within several hours) by using this combination. Various performance tests were carried out on image processing sub-system in 1990 using TV images obtained from different types of spent fuel assemblies stored in various storage pools of PWR and BWR power stations

  13. Text World Theory and real world readers: From literature to life in a Belfast prison.

    Canning, Patricia


    Cognitive stylistics offers a range of frameworks for understanding (amongst other things) what producers of literary texts 'do' with language and how they 'do' it. Less prevalent, however, is an understanding of the ways in which these same frameworks offer insights into what readers 'do' (and how they 'do' it). Text World Theory (Werth, 1999; Gavins, 2007; Whiteley, 2011) has proved useful for understanding how and why readers construct mental representations engendered by the act of reading. However, research on readers' responses to literature has largely focused on an 'idealised' reader or an 'experimental' subject-reader often derived from within the academy and conducted using contrived or amended literary fiction. Moreover, the format of traditional book groups (participants read texts privately and discuss them at a later date) as well as online community forums such as Goodreads, means that such studies derive data from post-hoc, rather than real-time textual encounters and discussions. The current study is the first of its kind in analysing real-time reading contexts with real readers during a researcher-led literary project ('') in Northern Ireland's only female prison. In doing so, the study is unique in addressing experimental and post hoc bias. Using Text World Theory, the paper considers the personal and social impact of reader engagement in the talk of the participants. As such, it has three interrelated aims: to argue for the social and personal benefits of reading stylistically rich literature in real-time reading groups; to demonstrate the efficacy of stylistics for understanding how those benefits come about, and to demonstrate the inter-disciplinary value of stylistics, particularly its potential for traversing traditional research parameters.

  14. "It Makes Me Really Want To Read": Struggling Readers Discover Literature.

    Primeaux, Joan


    Presents a project where the teacher, rather than teaching the students how to read using a remedial, isolated skills approach, concerned herself with getting them to read by "falling into the literature" and getting involved in the characters' lives. Describes a reader response approach that was designed to motivate the students to engage with…

  15. Perceptions of the Concerned Reader: An Analysis of the Subscribers of E/The Environmental Magazine.

    Labbe, Colleen P.; Fortner, Rosanne W.


    Describes a study aimed at determining if 'E/The Environmental Magazine' has met two goals: (1) its subscribers' need for environmental information and (2) its publishers' goal of inspiring environmentally responsible behavior. Results indicate that the level of the magazine's influence varied according to the reader's behavior category.…

  16. The Monolingual Cataloging Monolith: A Barrier to Library Access for Readers of Spanish.

    Jensen, Bruce


    Asserts that despite growing awareness of frontline public service concerns in accommodating Spanish speakers, little care is invested in the technical processing side of the library's responsibility to Spanish speakers. Examines the usefulness and accessibility of online public access catalogs for monolingual Spanish readers, focusing on records…

  17. "Spaces Invested with Content": Crossing the "Gaps" in Comics with Readers in Schools

    Low, David


    In recent years, reading scholars have increasingly attended to children's responses to picturebook page breaks, reasoning that the inferences young readers make during the turning of the page are central to understanding how children construct continuous narratives in semiotically rich texts. In this paper I argue that comics (including comic…

  18. The Role of Critical Thinking in Reader Perceptions of Leadership in Comic Books

    Krusemark, Renee


    This study qualitatively explored how readers use critical thinking to perceive leadership in "The Walking Dead" comic books. Sixty-nine participants gave responses regarding their thoughts about leadership in the comic via an online survey. A majority of the participants indicated a wide range of values for comics as a learning…

  19. Orthographic learning and the role of text-to-speech software in Dutch disabled readers.

    Staels, Eva; Van den Broeck, Wim


    In this study, we examined whether orthographic learning can be demonstrated in disabled readers learning to read in a transparent orthography (Dutch). In addition, we tested the effect of the use of text-to-speech software, a new form of direct instruction, on orthographic learning. Both research goals were investigated by replicating Share's self-teaching paradigm. A total of 65 disabled Dutch readers were asked to read eight stories containing embedded homophonic pseudoword targets (e.g., Blot/Blod), with or without the support of text-to-speech software. The amount of orthographic learning was assessed 3 or 7 days later by three measures of orthographic learning. First, the results supported the presence of orthographic learning during independent silent reading by demonstrating that target spellings were correctly identified more often, named more quickly, and spelled more accurately than their homophone foils. Our results support the hypothesis that all readers, even poor readers of transparent orthographies, are capable of developing word-specific knowledge. Second, a negative effect of text-to-speech software on orthographic learning was demonstrated in this study. This negative effect was interpreted as the consequence of passively listening to the auditory presentation of the text. We clarify how these results can be interpreted within current theoretical accounts of orthographic learning and briefly discuss implications for remedial interventions. © Hammill Institute on Disabilities 2013.

  20. Reader characteristics linked to detection of pulmonary nodules on radiographs: ROC vs. JAFROC analyses of performance

    Kohli, Akshay; Robinson, John W.; Ryan, John; McEntee, Mark F.; Brennan, Patrick C.


    The purpose of this study is to explore whether reader characteristics are linked to heightened levels of diagnostic performance in chest radiology using receiver operating characteristic (ROC) and jackknife free response ROC (JAFROC) methodologies. A set of 40 postero-anterior chest radiographs was developed, of which 20 were abnormal containing one or more simulated nodules, of varying subtlety. Images were independently reviewed by 12 boardcertified radiologists including six chest specialists. The observer performance was measured in terms of ROC and JAFROC scores. For the ROC analysis, readers were asked to rate their degree of suspicion for the presence of nodules by using a confidence rating scale (1-6). JAFROC analysis required the readers to locate and rate as many suspicious areas as they wished using the same scale and resultant data were used to generate Az and FOM scores for ROC and JAFROC analyses respectively. Using Pearson methods, scores of performance were correlated with 7 reader characteristics recorded using a questionnaire. JAFROC analysis showed that improved reader performance was significantly (pchest specialty (pchest radiographs (pchest readings per year (pchest radiographs (pchest specialty, hours reading per week and number of radiographs read per year. Also, JAFROC is a more powerful predictor of performance as compared to ROC.

  1. Unforgivable Blackness: Visual Rhetoric, Reader Response, and Critical Racial Literacy

    Gardner, Roberta Price


    Perceptions of black representations in literature and other visual mediums as positive or negative continuously cause consternation and debate (Fleetwood, 2011). Because African American children are literacy participants and consumers, they are not immune from experiencing this tension. This essay considers the effects and affective threads of…

  2. Re-configuring Aristotle's Dialogics through Reader-Response.

    Khawaja, Mabel

    In her literature and composition classes, an educator encourages students to correlate their memory and imagination to the rhetorical elements of logos, pathos, and ethos and construct regenerative structures of knowledge through a comprehensive and objective understanding of a contextualized problem. She employs Bakhtin's dialogic method of…

  3. Reader performance in visual assessment of breast density using visual analogue scales: Are some readers more predictive of breast cancer?

    Rayner, Millicent; Harkness, Elaine F.; Foden, Philip; Wilson, Mary; Gadde, Soujanya; Beetles, Ursula; Lim, Yit Y.; Jain, Anil; Bundred, Sally; Barr, Nicky; Evans, D. Gareth; Howell, Anthony; Maxwell, Anthony; Astley, Susan M.


    Mammographic breast density is one of the strongest risk factors for breast cancer, and is used in risk prediction and for deciding appropriate imaging strategies. In the Predicting Risk Of Cancer At Screening (PROCAS) study, percent density estimated by two readers on Visual Analogue Scales (VAS) has shown a strong relationship with breast cancer risk when assessed against automated methods. However, this method suffers from reader variability. This study aimed to assess the performance of PROCAS readers using VAS, and to identify those most predictive of breast cancer. We selected the seven readers who had estimated density on over 6,500 women including at least 100 cancer cases, analysing their performance using multivariable logistic regression and Receiver Operator Characteristic (ROC) analysis. All seven readers showed statistically significant odds ratios (OR) for cancer risk according to VAS score after adjusting for classical risk factors. The OR was greatest for reader 18 at 1.026 (95% Cl 1.018-1.034). Adjusted Area Under the ROC Curves (AUCs) were statistically significant for all readers, but greatest for reader 14 at 0.639. Further analysis of the VAS scores for these two readers showed reader 14 had higher sensitivity (78.0% versus 42.2%), whereas reader 18 had higher specificity (78.0% versus 46.0%). Our results demonstrate individual differences when assigning VAS scores; one better identified those with increased risk, whereas another better identified low risk individuals. However, despite their different strengths, both readers showed similar predictive abilities overall. Standardised training for VAS may improve reader variability and consistency of VAS scoring.

  4. Skilled deaf readers have an enhanced perceptual span in reading.

    Bélanger, Nathalie N; Slattery, Timothy J; Mayberry, Rachel I; Rayner, Keith


    Recent evidence suggests that, compared with hearing people, deaf people have enhanced visual attention to simple stimuli viewed in the parafovea and periphery. Although a large part of reading involves processing the fixated words in foveal vision, readers also utilize information in parafoveal vision to preprocess upcoming words and decide where to look next. In the study reported here, we investigated whether auditory deprivation affects low-level visual processing during reading by comparing the perceptual span of deaf signers who were skilled and less-skilled readers with the perceptual span of skilled hearing readers. Compared with hearing readers, the two groups of deaf readers had a larger perceptual span than would be expected given their reading ability. These results provide the first evidence that deaf readers' enhanced attentional allocation to the parafovea is used during complex cognitive tasks, such as reading.

  5. Readers Theatre : Dramatising environment issues for oral skills development

    Paatrick Ng Chin Leong


    Readers Theatre was introduced to a class of Japanese students studying intermediate-level English in an international university in Japan. The aim of the study is to investingate whether Readers Theatre enhances the oral skills of Japanese students as they negotiate an environmental issue in English. In my presentation, I will demonstrate how Readers Theatre is implemented in class and the comments by students will be analysed and discussed during the presentation.

  6. Savings for the Poor

    Ignacio Mas


    This paper reviews the relevance of formal financial services – in particular, savings – to poor people, the economic factors that have hindered the mass-scale delivery of such services in developing countries, and the technology-based opportunities that exist today to make massive gains in financial inclusion. It also highlights the benefits to government from universal financial access, as well as the key policy enablers that would need to be put in place to allow the necessary innovati...

  7. Poorly Differentiated Thyroid Carcinoma.

    Setia, Namrata; Barletta, Justine A


    Poorly differentiated thyroid carcinoma (PDTC) has been recognized for the past 30 years as an entity showing intermediate differentiation and clinical behavior between well-differentiated thyroid carcinomas (ie, papillary thyroid carcinoma and follicular thyroid carcinoma) and anaplastic thyroid carcinoma; however, there has been considerable controversy around the definition of PDTC. In this review, the evolution in the definition of PDTC, current diagnostic criteria, differential diagnoses, potentially helpful immunohistochemical studies, and molecular alterations are discussed with the aim of highlighting where the diagnosis of PDTC currently stands. Published by Elsevier Inc.

  8. The e-Reader — an Educational or an Entertainment Tool? e-Readers in an Academic Setting

    Peter Ahlroos


    Full Text Available In this paper the authors will discuss a pilot project conducted at the Tritonia Academic Library, Vaasa, in Finland, from September 2010 until May 2011. The project was designed to investigate the application of e-readers in academic settings and to learn how teachers and students experience the use of e-readers in academic education. Four groups of students and one group of teachers used Kindle readers for varied periods of time in different courses. The course material and the textbooks were downloaded on the e-readers. The feedback from the participants was collected through questionnaires and teacher interviews. The results suggest that the e-reader is a future tool for learning, though some features need to be improved before e-readers can really enable efficient learning and researching.

  9. Morpho-phonemic analysis boosts word reading for adult struggling readers.

    Gray, Susan H; Ehri, Linnea C; Locke, John L


    A randomized control trial compared the effects of two kinds of vocabulary instruction on component reading skills of adult struggling readers. Participants seeking alternative high school diplomas received 8 h of scripted tutoring to learn forty academic vocabulary words embedded within a civics curriculum. They were matched for language background and reading levels, then randomly assigned to either morpho-phonemic analysis teaching word origins, morpheme and syllable structures, or traditional whole word study teaching multiple sentence contexts, meaningful connections, and spellings. Both groups made comparable gains in learning the target words, but the morpho-phonemic group showed greater gains in reading unfamiliar words on standardized tests of word reading, including word attack and word recognition. Findings support theories of word learning and literacy that promote explicit instruction in word analysis to increase poor readers' linguistic awareness by revealing connections between morphological, phonological, and orthographic structures within words.

  10. [Poor insight and psychosis].

    Giotakos, O


    A variety of phenomena might be considered as reflecting impaired insight in psychosis, like failure to recognize signs, symptoms or disease, failure to derive appropriate cognitive representations, despite recognition of the disease, and misattribution of the source or cause of the disease. The unawareness of tardive dyskinesia symptoms in schizophrenic patients points that self-awareness deficits in schizophrenia may be domain specific. Poor insight is an independent phenomenological and a prevalent feature in psychotic disorders in general, and in schizophrenia in particular, but we don't know yet if delusions in schizophrenia are the result of an entirely normal attempt to account for abnormal perceptual experiences or a product of abnormal experience but of normal reasoning. The theoretical approaches regarding impaired insight include the disturbed perceptual input, the impaired linkage between thought and emotion and the breakdown of the process of self-monitoring and error checking. The inability to distinguish between internally and externally generated mental events has been described by the metarepresentation theory. This theory includes the awareness of ones' goals, which leads to disorders of willed action, the awareness of intention, which leads to movement disorders, and the awareness of intentions of others, which leads to paranoid delusions. The theory of metarepresentation implies mainly output mechanisms, like the frontal cortex, while the input mechanism implies posterior brain systems, including the parietal lobe. There are many similarities between the disturbances of awareness seen in schizophrenia and those seen as a result of known neurological impairment. Neuropsychological models of impaired insight typically attribute the disturbance to any of a variety of core deficits in the processing of information. In this respect, lack of insight is on conceptual par with alogia, apraxia or aphasia in reflecting disturbed cognitive processing. In

  11. Relationship between Reading/Writing Skills and Cognitive Abilities among Japanese Primary-School Children: Normal Readers versus Poor Readers (Dyslexics)

    Uno, Akira; Wydell, Taeko N.; Haruhara, Noriko; Kaneko, Masato; Shinya, Naoko


    Four hundred and ninety-five Japanese primary-school children aged from 8 (Grade-2) to 12 (Grade-6) were tested for their abilities to read/write in Hiragana, Katakana, and Kanji, for their size of vocabulary and for other cognitive abilities including arithmetic, visuo-spatial and phonological processing. Percentages of the children whose…

  12. The 'poor man's laryngogram'

    Bartelt, D.


    This paper is reassessment of an old method improved by well-directed application of well-known maneuvers of laryngo-pharyngeal function. Although not as visually attractive as a dedicated laryngogram (now hardly ever requested), it does render similarly reliable diagnostic information, which, supported, as occasionally necessary, by conventional tomography, can even surpass that given by the older technique. Its main advantage lies in providing cheap, quick, noninvasive studies with minimal descomfort for the patient. Should further investigation be necessary, for analysis of deep extension, modern cross-sectional imaging methods (especially MR) far surpass even dedicated laryngography in diagnostic value and can be based adequately on 'poor mans's laryngography'. Ways in which this method may be optimised, especially those involving laryngopharyngeal function, are briefly presented - with emphasis on relevant practical aspects - as are normal and abnormal findings. (orig.) [de

  13. REMO poor man's reanalysis

    Ries, H.; Moseley, C.; Haensler, A.


    Reanalyses depict the state of the atmosphere as a best fit in space and time of many atmospheric observations in a physically consistent way. By essentially solving the data assimilation problem in a very accurate manner, reanalysis results can be used as reference for model evaluation procedures and as forcing data sets for different model applications. However, the spatial resolution of the most common and accepted reanalysis data sets (e.g. JRA25, ERA-Interim) ranges from approximately 124 km to 80 km. This resolution is too coarse to simulate certain small scale processes often associated with extreme events. In addition, many models need higher resolved forcing data ( e.g. land-surface models, tools for identifying and assessing hydrological extremes). Therefore we downscaled the ERA-Interim reanalysis over the EURO-CORDEX-Domain for the time period 1989 to 2008 to a horizontal resolution of approximately 12 km. The downscaling is performed by nudging REMO-simulations to lower and lateral boundary conditions of the reanalysis, and by re-initializing the model every 24 hours ("REMO in forecast mode"). In this study the three following questions will be addressed: 1.) Does the REMO poor man's reanalysis meet the needs (accuracy, extreme value distribution) in validation and forcing? 2.) What lessons can be learned about the model used for downscaling? As REMO is used as a pure downscaling procedure, any systematic deviations from ERA-Interim result from poor process modelling but not from predictability limitations. 3.) How much small scale information generated by the downscaling model is lost with frequent initializations? A comparison to a simulation that is performed in climate mode will be presented.

  14. Co-editors’ Note to Readers

    Wen-hsin Yeh


    Full Text Available Dear Cross-Currents readers, We are pleased to present you with the fifteenth quarterly issue of the Cross-Currents e-journal. The research articles in the June 2015 issue—guest edited by Elena Barabantseva (University of Manchester, Xiang Biao (University of Oxford, and Antonia Chao (Tunghai University—explore the theme “Governing Marriage Migrations: Perspectives from Mainland China and Taiwan.” The issue includes five articles by scholars from Japan, Germany, the UK, Taiwan, and Hong Kong who are engaged in critical analysis of cross-border migration for the purpose of marriage in the People’s Republic of China and Taiwan as a subject of governance. As the guest editors emphasize in their introduction, cross-border marriage is “perceived to be inseparable from a wide range of other issues, such as sexual morality, family norms, national identity, and border security.” The contributors—Hongfang Hao (Kyoto University, Caroline Grillot (Max Planck Institute for Social Anthropology, Elena Barabantseva (University of Manchester, Mei-Hua Chen (National Sun Yat-sen University, and Hsun-Hui Tseng (Chinese University of Hong Kong—offer valuable new insights on international marriage migration in their multidisciplinary and fieldwork-based studies...

  15. Breaking the Silence: Toward Improving LGBTQ Representation in Composition Readers

    Hudson, John


    Lesbian-Gay-Bisexual-Transgender-Queer (LGBTQ) representation in composition readers remains limited and is frequently nonexistent. In addition, the LGBTQ-related materials that do find their way into composition readers are often problematic. In this essay I explain why WPAs and composition teachers should be concerned about LGBTQ representation…

  16. Accelerated Reader Program: What Do Teachers Really Think?

    Smith, Amy Frances; Westberg, Karen; Hejny, Anne


    What do teachers really think about the Accelerated Reader program, a widely used supplemental, independent reading program in which their students read fiction and non-fiction books of their choice and take brief online comprehension quizzes about the books? The Accelerated Reader (AR) program was designed by Renaissance Learning Company to…

  17. Eye Movements Reveal Readers' Lexical Quality and Reading Experience

    Taylor, Jessica Nelson; Perfetti, Charles A.


    Two experiments demonstrate that individual differences among normal adult readers, including lexical quality, are expressed in silent reading at the word level. In the first of two studies we identified major dimensions of variability among college readers and among words using factor analysis. We then examined the effects of these dimensions of…

  18. Infographics for Educational Purposes: Their Structure, Properties and Reader Approaches

    Yildirim, Serkan


    Infographics are one of the new educational environments used to provide information to their readers in a visual way. Infographics are designed to provide information to their readers using various visuals such as texts, pictures, drawings, diagrams, graphs, etc. The use of infographics becomes increasingly widespread both in advertising…

  19. How the Relationship between Text and Headings Influences Readers' Memory

    Ritchey, Kristin; Schuster, Jonathan; Allen, Jaryn


    Two questions regarding signals' influence on memory were examined. First, the relationship between headings and text was manipulated to determine whether headings serve as visual cues, directing readers to recall all subsequent information, or content-specific cues, directing readers to recall only to certain information. Second, distance between…

  20. Are You Ready for E-Readers in Your Library?

    Gustafson, Chris


    This article discusses some things to consider when thinking about adding e-readers to one's collection. These include: (1) What is the purpose?; (2) Which device?; (3) How will one keep track of his or her e-readers and their contents?; (4) What are some potential pitfalls?; (5) Is there a positive impact on student learning?; and (6) Are…

  1. Sexism Springs Eternal--in the Reader's Digest.

    Zimbardo, Philip G.; Meadow, Wendy

    This document reports on an empirical investigation of anti-women humor appearing in the Reader's Digest over three decades, revealing the operation of an unconscious sexist ideology. A systematic analysis was made of 1,069 jokes appearing in two featured columns of the Reader's Digest for the two-year periods 1947-48, 1957-58, and 1967-68.…

  2. A Comparative Review of Stratification Texts and Readers

    Peoples, Clayton D.


    Social stratification is a core substantive area within sociology. There are a number of textbooks and readers available on the market that deal with this central topic. In this article, I conduct a comparative review of (a) four stratification textbooks and (b) four stratification readers. (Contains 2 tables.)

  3. Chinese Deaf Readers Have Early Access to Parafoveal Semantics

    Yan, Ming; Pan, Jinger; Bélanger, Nathalie N.; Shu, Hua


    In the present study, we manipulated different types of information available in the parafovea during the reading of Chinese sentences and examined how deaf readers make use of the parafoveal information. Results clearly indicate that although the reading-level matched hearing readers make greater use of orthographic information in the parafovea,…

  4. Resolving Struggling Readers' Homework Difficulties: A Social Cognitive Perspective

    Margolis, Howard; Mccabe, Patrick


    Struggling readers often fail to complete homework or complete it in a slipshod, haphazard fashion. Often, this adversely affects grades, erodes motivation for academics, and causes conflict between readers, parents, and school personnel. To help teachers and educational consultants (e.g., reading specialists, school psychologists) help struggling…

  5. Organizing Instruction for Struggling Readers in Tutorial Settings

    Mokhtari, Kouider; Hutchison, Amy C.; Edwards, Patricia A.


    In this article, the authors suggest that many of the problems struggling readers encounter while reading stem from distinct yet fundamental sources of difficulty related to the types of text read (print or online), the task or activity readers engage in, and the sociocultural context of reading. The authors further argue that although these…

  6. Addressing Learning Disabilities with UDL and Technology: Strategic Reader

    Hall, Tracey E.; Cohen, Nicole; Vue, Ge; Ganley, Patricia


    CAST created "Strategic Reader," a technology-based system blending Universal Design for Learning (UDL) and Curriculum-Based Measurement (CBM) in a digital learning environment to improve reading comprehension instruction. This experimental study evaluates the effectiveness of Strategic Reader using two treatment conditions for measuring…

  7. Peace Pilgrim: A Readers Theatre Approach to Peace Education.

    Curran, Joanne M.

    Readers theater is a dramatic art that directs attention to the words of a text. During a performance, a reader (rather than an actor) presents and interprets the work within a narrative context intended by the author. In this project, the text, a collection of the words and writings of a woman known as the Peace Pilgrim, tells the story of her…

  8. Finding versus Fixing: Self-Monitoring for Readers Who Struggle

    Anderson, Nancy L.; Kaye, Elizabeth L.


    This article explains how teachers can understand, notice, and supportively respond to readers who struggle with self-monitoring during text reading. The unique strategic processing demands for readers who struggle support the argument that teaching children to find and notice errors is different than fixing a word, or getting it right. Three…


    Gernsbacher, Morton Ann


    One approach to understanding the component processes and mechanisms underlying adult reading skill is to compare the performance of more skilled and less skilled readers on laboratory experiments. The results of some recent experiments employing this approach demonstrate that less skilled adult readers suppress less efficiently the inappropriate meanings of ambiguous words (e.g., the playing card vs. garden tool meanings of spade ), the incorrect forms of homophones (e.g., patients vs. patience ), the typical-but-absent members of scenes (e.g., a tractor in a farm scene), and words superimposed on pictures. Less skilled readers are not less efficient in activating contextually appropriate information; in fact, they activate contextually appropriate information more strongly than more skilled readers do. Therefore, one conclusion that can be drawn from these experiments is that less skilled adult readers suffer from less efficient suppression mechanisms.

  10. Overview of PADC nuclear track readers. Recent trends and solutions

    Hulber, E.


    The development of automated track readers dates back to the first routine dosimetry applications of solid state nuclear track detectors. Many research-laboratory track readers and a few commercial systems were introduced in the past 25 years. The traditional application area for high-throughput track readers is radon testing in buildings and fast neutron dosimetry. The latter application, in particular, has considerably increased the need for efficient polyallyldiglycol carbonate (PADC) track reader systems with high throughput. The paper provides an overview of recent trends in the development of high-throughput PADC track readers and it gives a glimpse into the practice of designing this category of devices. A general overview is provided of the technical aspects relating to the optics, the hardware and the track recognition approaches. Ultimate theoretical limits in the performance as well as promising new approaches are addressed. Requirements and practical solutions are illustrated with reference to a commercially available system.

  11. Migrant readers and wordless books: visual narratives’ inclusive experience

    Giorgia Grilli


    Full Text Available The research here told is the Italian contribution to the international project Visual Journeys: Understanding Immigrant Children’s Response to Visual Images in Picturebooks, Conducted in Scotland, Arizona, Spain and Australia as an Observation of the Response of Migrant ten-eleven years old Readers to the Wordless Book The Arrival by Shaun Tan (2006. Reflections are made about co-construction and negotiation of meaning in a shared reading; wordless book is experienced as occasion of empowerment for those involved, giving value to individual stories and showing a positive outcome in school life, as for self-esteem and reciprocal relationships; it promotes discussion and increases interest in books, it shows an important effect on learning a foreign language and creating a group. The perspective of the whole experience is an interdisciplinary approach. The reading of wordless or silent book can be a true practice of right and belonging to the international community, and therefore a precious means for an education to global citizenship.

  12. The role of working memory and fluency practice on the reading comprehension of students who are dysfluent readers.

    Swanson, H Lee; O'Connor, Rollanda


    The authors investigated whether practice in reading fluency had a causal influence on the relationship between working memory (WM) and text comprehension for 155 students in Grades 2 and 4 who were poor or average readers. Dysfluent readers were randomly assigned to repeated reading or continuous reading practice conditions and compared with untreated dysfluent and fluent readers on posttest measures of fluency, word identification, vocabulary, and reading comprehension. Three main findings emerged: (a) The influence of WM on text comprehension was not related to fluency training, (b) dysfluent readers in the continuous-reading condition had higher posttest scores than dysfluent readers in the other conditions on measures of text comprehension but not on vocabulary, and (c) individual differences in WM better predicted posttest comprehension performance than word-attack skills. In general, the results suggested that although continuous reading increased comprehension, fluency practice did not compensate for WM demands. The results were interpreted within a model that viewed reading comprehension processes as competing for a limited supply of WM resources that operate independent of fluency.

  13. «Reader! Bruder!»: The Rhetoric of Narration and the Rhetoric of Reading

    Federico Bertoni


    Full Text Available The paper deals with the relation of power established by narrative texts, exploring the many-sided field of articulation among the related subjects: the narrator as a subject of power, the text as a rhetorical device, and the reader as an ultimate guarantor of meaning. After a brief introduction on the “rebirth of rhetoric” in the second half of the Twentieth century, drawing attention to its links with Reader-response criticism, the paper  focuses on the “power of words” and analyzes three case-studies: Lolita by Vladimir Nabokov (1955, Money by Martin Amis (1984 and The Kindly Ones by Jonathan Littell (2006. These novels depend for their rhetorical effect on the invention of a special narrating voice and on the relationship that it establishes with the reader – an odd mixture of antagonism and complicity, seduction and persuasion. The reader is thus invoked as a brother, but an ambiguous and untrustworthy one, as archetypally described in last verse of the opening poem from Baudelaire’s Les Fleurs du mal: «hypocrite lecteur – mon semblable, mon frère».

  14. How Specific are Specific Comprehension Difficulties? An Investigation of Poor Reading Comprehension in Nine-Year-Olds

    Rønberg, Louise; Petersen, Dorthe Klint


    comprehenders, the poor comprehenders’ orthographic coding and daily reading of literary texts were significantly below those of average readers. This study indicates that a lack of reading experience, and likewise, a lack of fluent word reading, may be important factors in understanding 9-year-old poor...

  15. Examining College Students’ Reading Behaviors and Needs for Ebook Readers

    Wei-Jane Lin


    Full Text Available This study investigates college students’ reading behaviors and attitudes toward print and electronic carriers of books. With the prosperity and variety of ebook readers currently, it is important to understand the genuine needs of the users to better leverage the features and functions of the ebook readers. The methodology of survey research is conducted to explore 76 undergraduate students’ experiences, preferences and appraisals toward reading via the print books and ebook readers. Generally the college students possess positive attitudes toward and are willing to take advantage of the ebook and ebook reader services provided by libraries, but the current rate of use is low. The results suggested that student adoption of ebook readers are affected by their goals of reading. The college students prefer ebook readers significantly for leisure reading, and highly demand the functionality of multimedia presentations and file management. When reading academic contexts, the college students preferred hardcovers and online ebooks via the Web browser, and they value the functions of searching, marking and file management on ebook readers especially. [Article content in Chinese

  16. E-Books on the Mobile E-Reader

    Chulyun Kim


    Full Text Available The market for e-books has been established during the past several years. Many e-book readers are commercially available, and millions of e-book titles are available for purchase or free download. E-paper technology has matured enough to be used as the screen for dedicated e-book readers which make reading possible with the familiar feel of reading printed books. In this paper, we provide a comprehensive review of the status of the e-book, including the architecture and features of e-book readers, market adoption and e-book industry ecosystem.

  17. Journal of Clipped Words in Reader's Digest Magazine

    Simanjuntak, Lestari


    This study deals with Clipped Words in the “Laughter, the Best Medicine” of Reader's Digest. The objectives of the study are to find out the types of clipped words which are used in the “Laughter, the Best Medicine” of Reader's Digest, to find out sthe dominantly used in the whole story and to reason the dominant clipped word use in the text. The study use descriptive qualitative method. The data were collected from seventeen selected Reader's Digest which contains the clipped word by applie...

  18. Usability and Accessibility of eBay by Screen Reader

    Buzzi, Maria Claudia; Buzzi, Marina; Leporini, Barbara; Akhter, Fahim

    The evolution of Information and Communication Technology and the rapid growth of the Internet have fuelled a great diffusion of eCommerce websites. Usually these sites have complex layouts crowded with active elements, and thus are difficult to navigate via screen reader. Interactive environments should be properly designed and delivered to everyone, including the blind, who usually use screen readers to interact with their computers. In this paper we investigate the interaction of blind users with eBay, a popular eCommerce website, and discuss how using the W3C Accessible Rich Internet Applications (WAI-ARIA) suite could improve the user experience when navigating via screen reader.

  19. Power Efficient Gurumukhi Unicode Reader Design and Implementation on FPGA

    Kaur, Amanpreet; Singh, Sunny; Pandey, Bishwajeet


    Gurumukhi is found to be the most widely used language of Pakistan, and it is ranked 3rd in Canada, 7th in India and almost 4th most spoken language in U.K. This Unicode Reader is cost effective solution for learning as well as understanding the Punjabi language by the people across the globe .This...... reader helps the user to understand, whether written text is consonants, vowels or digits of Gurumukhi scripts. This paper can also be the solution to the various problems occurred in research of Punjabi natural language processing. Hardware is designed for Gurumukhi Unicode Reader (GUR...

  20. Added value of one-view breast tomosynthesis combined with digital mammography according to reader experience

    Thomassin-Naggara, Isabelle; Perrot, Nicolas; Dechoux, Sophie; Ribeiro, Carine; Chopier, Jocelyne; Bazelaire, Cedric de


    Highlights: • Breast tomosynthesis improves diagnostic performance especially for radiologists with lower experience in mammography. • Adding only one-view digital breast tomosynthesis to mammography improves the cancer detection rate. • Breast tomosynthesis is mainly useful for helping radiologists to detect architectural distortion. - Abstract: Purpose: To retrospectively evaluate the added value of one-view breast tomosynthesis in adjunct with mammography to characterize breast lesions. Materials and methods: Our institutional ethics committees approved the study and granted a waiver of informed consent. One hundred fifty-five women (mean age, 51.3 years, range: 24–92 years) who systematically underwent mammography and breast tomosynthesis with subsequent percutaneous biopsy were analyzed. Four radiologists (two seniors, R1 and R2, and two juniors, R3 and R4 with 30, 10, 3 and 1 years of experience in breast imaging, respectively) independently reviewed exams in two steps: mammography alone and tomosynthesis in adjunct with mammography. The lesions in the cohort included 39.3% (61/155) cancers, 2.5% (4/155) high-risk lesions and 58.1% (90/155) benign lesions. A receiver operating characteristic (ROC) curve analysis was performed to compare the results of the two readings. Results: There was almost perfect agreement irrespective of reader experience for the reading of the mammography in adjunct with tomosynthesis, whereas agreement was poor between junior and senior readers for the reading of mammography alone. Area under the ROC (Az) values for the tomosynthesis in adjunct with mammography were significantly better than Az values for mammography alone for all readers except the most experienced, for whom only a tendency was noted. The proportion of cancers undiagnosed by mammography alone that were well diagnosed by tomosynthesis in adjunct with mammography was 6.5% (4/61), 13.1% (8/61), 27.8% (17/61) and 26.2% (16/61) for Readers 1, 2, 3 and 4

  1. Added value of one-view breast tomosynthesis combined with digital mammography according to reader experience

    Thomassin-Naggara, Isabelle, E-mail: [Sorbonne Universités, UPMC Univ Paris 06, IUC, 75005 Paris (France); INSERM, UMR970, Equipe 2, Imagerie de l’angiogenèse, 75005 Paris (France); AP-HP, Hôpital Tenon, Department of Radiology, 4 rue de la Chine, 75020 Paris (France); Perrot, Nicolas [AP-HP, Hôpital Tenon, Department of Radiology, 4 rue de la Chine, 75020 Paris (France); Centre Pyramides, Paris (France); Dechoux, Sophie [Sorbonne Universités, UPMC Univ Paris 06, IUC, 75005 Paris (France); AP-HP, Hôpital Tenon, Department of Radiology, 4 rue de la Chine, 75020 Paris (France); Ribeiro, Carine [Centre Pyramides, Paris (France); Chopier, Jocelyne [AP-HP, Hôpital Tenon, Department of Radiology, 4 rue de la Chine, 75020 Paris (France); Bazelaire, Cedric de [APHP, Department of Radiology, Hôpital Saint Louis, 75010 Paris (France)


    Highlights: • Breast tomosynthesis improves diagnostic performance especially for radiologists with lower experience in mammography. • Adding only one-view digital breast tomosynthesis to mammography improves the cancer detection rate. • Breast tomosynthesis is mainly useful for helping radiologists to detect architectural distortion. - Abstract: Purpose: To retrospectively evaluate the added value of one-view breast tomosynthesis in adjunct with mammography to characterize breast lesions. Materials and methods: Our institutional ethics committees approved the study and granted a waiver of informed consent. One hundred fifty-five women (mean age, 51.3 years, range: 24–92 years) who systematically underwent mammography and breast tomosynthesis with subsequent percutaneous biopsy were analyzed. Four radiologists (two seniors, R1 and R2, and two juniors, R3 and R4 with 30, 10, 3 and 1 years of experience in breast imaging, respectively) independently reviewed exams in two steps: mammography alone and tomosynthesis in adjunct with mammography. The lesions in the cohort included 39.3% (61/155) cancers, 2.5% (4/155) high-risk lesions and 58.1% (90/155) benign lesions. A receiver operating characteristic (ROC) curve analysis was performed to compare the results of the two readings. Results: There was almost perfect agreement irrespective of reader experience for the reading of the mammography in adjunct with tomosynthesis, whereas agreement was poor between junior and senior readers for the reading of mammography alone. Area under the ROC (Az) values for the tomosynthesis in adjunct with mammography were significantly better than Az values for mammography alone for all readers except the most experienced, for whom only a tendency was noted. The proportion of cancers undiagnosed by mammography alone that were well diagnosed by tomosynthesis in adjunct with mammography was 6.5% (4/61), 13.1% (8/61), 27.8% (17/61) and 26.2% (16/61) for Readers 1, 2, 3 and 4

  2. Added value of one-view breast tomosynthesis combined with digital mammography according to reader experience.

    Thomassin-Naggara, Isabelle; Perrot, Nicolas; Dechoux, Sophie; Ribeiro, Carine; Chopier, Jocelyne; de Bazelaire, Cedric


    To retrospectively evaluate the added value of one-view breast tomosynthesis in adjunct with mammography to characterize breast lesions. Our institutional ethics committees approved the study and granted a waiver of informed consent. One hundred fifty-five women (mean age, 51.3 years, range: 24-92 years) who systematically underwent mammography and breast tomosynthesis with subsequent percutaneous biopsy were analyzed. Four radiologists (two seniors, R1 and R2, and two juniors, R3 and R4 with 30, 10, 3 and 1 years of experience in breast imaging, respectively) independently reviewed exams in two steps: mammography alone and tomosynthesis in adjunct with mammography. The lesions in the cohort included 39.3% (61/155) cancers, 2.5% (4/155) high-risk lesions and 58.1% (90/155) benign lesions. A receiver operating characteristic (ROC) curve analysis was performed to compare the results of the two readings. There was almost perfect agreement irrespective of reader experience for the reading of the mammography in adjunct with tomosynthesis, whereas agreement was poor between junior and senior readers for the reading of mammography alone. Area under the ROC (Az) values for the tomosynthesis in adjunct with mammography were significantly better than Az values for mammography alone for all readers except the most experienced, for whom only a tendency was noted. The proportion of cancers undiagnosed by mammography alone that were well diagnosed by tomosynthesis in adjunct with mammography was 6.5% (4/61), 13.1% (8/61), 27.8% (17/61) and 26.2% (16/61) for Readers 1, 2, 3 and 4, respectively. The proportion of false positive cases induced by the addition of breast tomosynthesis to mammography was 2.1% (2/94), 2.1% (2/94), 9.5% (9/94) and 12.7% (12/94) for Readers 1, 2, 3 and 4, respectively. Adding breast tomosynthesis to mammography improved sensitivity and negative predictive value for all readers except for the most experienced one, in whom only a tendency for improvement

  3. Phonological Working Memory in German Children with Poor Reading and Spelling Abilities

    Steinbrink, Claudia; Klatte, Maria


    Deficits in verbal short-term memory have been identified as one factor underlying reading and spelling disorders. However, the nature of this deficit is still unclear. It has been proposed that poor readers make less use of phonological coding, especially if the task can be solved through visual strategies. In the framework of Baddeley's…

  4. How Readers and Advertisers Benefit from Local Newspaper Competition.

    Everett, Shu-Ling Chen; Everett, Stephen E.


    Explores relations among three competitive schemes with respect to newspapers' price structures, including advertising rates and prices to consumers. Finds that readers get some benefit from greater competition, but that advertisers do not. (MM)

  5. 21 CFR 866.2850 - Automated zone reader.


    ...) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Microbiology Devices § 866.2850 Automated zone reader... surface of certain culture media used in disc-agar diffusion antimicrobial susceptibility tests. The...

  6. An Interview with Crosby Bonsall: A Writer for Beginning Readers.

    Cox, Carole


    Crosby Bonsall, a prolific author-illustrator for young readers, comments on many topics related to writing, illustrating, and young children's initial independent encounters with print in books. (HOD)

  7. the management of writer-reader interaction in newspaper editorials


    how dialogically expansive and contractive resources are used in this respect in editorials from different ... adopts a particular position and how they interact with potential readers. Engagement ..... An introductory tour through Appraisal Theory.


    Gernsbacher, Morton Ann


    One approach to understanding the component processes and mechanisms underlying adult reading skill is to compare the performance of more skilled and less skilled readers on laboratory experiments. The results of some recent experiments employing this approach demonstrate that less skilled adult readers suppress less efficiently the inappropriate meanings of ambiguous words (e.g., the playing card vs. garden tool meanings of spade), the incorrect forms of homophones (e.g., patients vs. patien...

  9. Flexible electronics enters the e-reader market

    Banks, Michael


    A company that was spun off from the physics department at the University of Cambridge in the UK 10 years ago released its first product last month. Plastic Logic, founded by Henning Sirringhaus and Richard Friend, launched an electronic reader that can display books, magazines and newspapers on a flexible, lightweight plastic display. The reader commercializes pioneering work first started over 20 years ago at the lab by the two physicists, who are based in the department's optoelectronics group.

  10. Inferential processes in readers with Down syndrome

    Rosende-Vázquez, Marta


    Full Text Available The aim of this work is to know if the source of the difficulty in making inferences, readers with Down syndrome, is in access to prior knowledge or constructing ideas from purely textual knowledge (based on Saldaña and Frith, 2002 for autism. Involved a sample of 20 students with Down syndrome and mild mental retardation (mean IQ = 60 and a control group of 20 children without cognitive deficits. They were matched as to their extent read metal age via Prueba de Evaluación del Retraso Lector (average 8 years. We created two experimental situations: a subjects had to generate inferences based on physical knowledge, b social inferences about knowledge. The ability to check and reaction times in the activation of inferences about physical and social knowledge. We also analyzed the influence that the effect "priming". Results showed: a a rate of correct inferences similar verification tasks between the two groups, b Down subjects take longer to access knowledge that the previous text, c reaction times used by subjects Down were higher in activating physical inferences, d there were no significant differences in the population without reaction times gap between physical and social inferences e subjects without deficits benefited effect "priming" in both types of inferences f Down subjects only improve reaction time in the inferences of social nature. El presente estudio pretende conocer si el origen de la dificultad para realizar inferencias, en lectores con Síndrome de Down, se encuentra en el acceso al conocimiento previo o en la construcción de ideas a partir del conocimiento puramente textual (basándonos en Saldaña y Frith, 2002 para autismo. Participó una muestra de 20 alumnos con Síndrome de Down y discapacidad mental leve (media de C.I.= 60 y un grupo control de 20 alumnos sin déficit cognitivo. Ambos fueron igualados en cuanto a su edad mental lectora medida a través de la Prueba de Evaluación del Retraso Lector (media 8 a

  11. Networks of reader and country status: an analysis of Mendeley reader statistics

    Robin Haunschild


    Full Text Available The number of papers published in journals indexed by the Web of Science core collection is steadily increasing. In recent years, nearly two million new papers were published each year; somewhat more than one million papers when primary research papers are considered only (articles and reviews are the document types where primary research is usually reported or reviewed. However, who reads these papers? More precisely, which groups of researchers from which (self-assigned scientific disciplines and countries are reading these papers? Is it possible to visualize readership patterns for certain countries, scientific disciplines, or academic status groups? One popular method to answer these questions is a network analysis. In this study, we analyze Mendeley readership data of a set of 1,133,224 articles and 64,960 reviews with publication year 2012 to generate three different networks: (1 The network based on disciplinary affiliations of Mendeley readers contains four groups: (i biology, (ii social sciences and humanities (including relevant computer sciences, (iii bio-medical sciences, and (iv natural sciences and engineering. In all four groups, the category with the addition “miscellaneous” prevails. (2 The network of co-readers in terms of professional status shows that a common interest in papers is mainly shared among PhD students, Master’s students, and postdocs. (3 The country network focusses on global readership patterns: a group of 53 nations is identified as core to the scientific enterprise, including Russia and China as well as two thirds of the OECD (Organisation for Economic Co-operation and Development countries.

  12. Environmental dose measurement with microprocessor based portable TLD reader

    Deme, S.; Apathy, I.; Feher, I.


    Application of TL method for environmental gamma-radiation dosimetry involves uncertainty caused by the dose collected during the transport from the point of annealing to the place of exposure and back to the place of evaluation. Should an accident occur read out is delayed due to the need to transport to a laboratory equipped with a TLD reader. A portable reader capable of reading out the TL dosemeter at the place of exposure ('in situ TLD reader') eliminates the above mentioned disadvantages. We have developed a microprocessor based portable TLD reader for monitoring environmental gamma-radiation doses and for on board reading out of doses on space stations. The first version of our portable, battery operated reader (named Pille - 'butterfly') was made at the beginning of the 80s. These devices used CaSO 4 bulb dosemeters and the evaluation technique was based on analogue timing circuits and analogue to digital conversion of the photomultiplier current with a read out precision of 1 μGy and a measuring range up to 10 Gy. The measured values were displayed and manually recorded. The version with an external power supply was used for space dosimetry as an onboard TLD reader

  13. Orthographic and Semantic Processing in Young Readers

    Polse, Lara R.; Reilly, Judy S.


    This investigation examined orthographic and semantic processing during reading acquisition. Children in first to fourth grade were presented with a target word and two response alternatives, and were asked to identify the semantic match. Words were presented in four conditions: an exact match and unrelated foil (STONE-STONE-EARS), an exact match…

  14. The Interactive Computer: Authors and Readers Online.

    Saccardi, Marianne


    Describes a computer-literature project for middle school and high school students that was developed through the Fairfield-Westchester Children's Reading Project (CT) to promote online discussions between students and authors. Classroom activities are described, project financing is discussed, and teacher responses that indicate positive effects…

  15. When High-Capacity Readers Slow Down and Low-Capacity Readers Speed Up: Working Memory and Locality Effects.

    Nicenboim, Bruno; Logačev, Pavel; Gattei, Carolina; Vasishth, Shravan


    We examined the effects of argument-head distance in SVO and SOV languages (Spanish and German), while taking into account readers' working memory capacity and controlling for expectation (Levy, 2008) and other factors. We predicted only locality effects, that is, a slowdown produced by increased dependency distance (Gibson, 2000; Lewis and Vasishth, 2005). Furthermore, we expected stronger locality effects for readers with low working memory capacity. Contrary to our predictions, low-capacity readers showed faster reading with increased distance, while high-capacity readers showed locality effects. We suggest that while the locality effects are compatible with memory-based explanations, the speedup of low-capacity readers can be explained by an increased probability of retrieval failure. We present a computational model based on ACT-R built under the previous assumptions, which is able to give a qualitative account for the present data and can be tested in future research. Our results suggest that in some cases, interpreting longer RTs as indexing increased processing difficulty and shorter RTs as facilitation may be too simplistic: The same increase in processing difficulty may lead to slowdowns in high-capacity readers and speedups in low-capacity ones. Ignoring individual level capacity differences when investigating locality effects may lead to misleading conclusions.

  16. The Interplay of Reader Goals, Working Memory, and Text Structure During Reading

    Bohn-Gettler, Catherine M.; Kendeou, Panayiota


    In the current study we examined the complex interactions of instructional context, text properties, and reader characteristics during comprehension. College students were tasked with the goal of reading for study versus entertainment (instructional context) while thinking-aloud about four different expository text structures (text properties). Working memory also was assessed (reader characteristics). Reading goals and working memory interacted to influence paraphrasing and non-coherence processes when thinking aloud. Reading goals, working memory, and text structure all interacted to influence text-based inferences. Text structure also influenced knowledge-based inferences. Post-reading recall was highest for those with the instructional goal of reading for study (compared to entertainment), as well as for problem-response and compare-contrast texts (compared to descriptive and chronological texts). Implications of the findings are discussed. PMID:25018581

  17. Summer-long grazing of high versus low endophyte (Neotyphodium coenophialum-infected tall fescue by growing beef steers results in distinct temporal blood analyte response patterns, with poor correlation to serum prolactin levels

    Joshua J. Jackson


    Full Text Available Previously, we reported the effects of fescue toxicosis on developing Angus-cross steer growth, carcass, hepatic mRNA and protein expression profiles of selected serum proteins, and blood clinical and chemical profiles, after summer-long grazing (85 d of high (HE- vs low (LE-endophyte-infected fescue pastures. We now report the temporal development of acute, intermediate, and chronic responses of biochemical and clinical blood analytes determined at specified time intervals (period 1, d 0 to 36; period 2, d 37 to 58; and period 3, d 59 to 85. Throughout the trial, the alkaloid concentrations of the HE forage was consistently 19 to 25 times greater (P < 0.049 the concentration in the LE forage, and HE vs LE steers had continuously lower (P < 0.049 serum prolactin (85%, cholesterol (27%, and albumin (5%, but greater red blood cells (7%. The HE steers had decreased (P = 0.003 ADG only during period 1 (-0.05 vs 0.4 kg/d. For period 1, HE steers had reduced (P < 0.090 numbers of eosinophils (55% and lymphocytes (18%, serum triglyceride (27%, and an albumin/globulin ratio (9%, but an increased bilirubin concentration (20%. During period 2, serum LDH activities were 18% lower (P = 0.022 for HE vs LE steers. During period 3, serum levels of ALP (32%, ALT (16%, AST (15%, creatine kinase (35%, glucose (10%, and LDH (23% were lower (P < 0.040 for HE steers. Correlation analysis of serum prolactin and other blood analytes revealed that triglycerides (P = 0.042 and creatinine (P = 0.021 were moderately correlated (r < 0.433 with HE serum prolactin. In conclusion, three HE-induced blood analyte response patterns were identified: continually altered, initially altered and subsequently recovered, or altered only after long-term exposure. Blood analytes affected by length of grazing HE vs LE forages were either not, or poorly, correlated with serum prolactin. These data reveal important, temporal, data about how young cattle respond to the challenge of consuming

  18. A very low geno2pheno false positive rate is associated with poor viro-immunological response in drug-naïve patients starting a first-line HAART.

    Armenia, Daniele; Soulie, Cathia; Di Carlo, Domenico; Fabeni, Lavinia; Gori, Caterina; Forbici, Federica; Svicher, Valentina; Bertoli, Ada; Sarmati, Loredana; Giuliani, Massimo; Latini, Alessandra; Boumis, Evangelo; Zaccarelli, Mauro; Bellagamba, Rita; Andreoni, Massimo; Marcelin, Anne-Geneviève; Calvez, Vincent; Antinori, Andrea; Ceccherini-Silberstein, Francesca; Perno, Carlo-Federico; Santoro, Maria Mercedes


    We previously found that a very low geno2pheno false positive rate (FPR ≤ 2%) defines a viral population associated with low CD4 cell count and the highest amount of X4-quasispecies. In this study, we aimed at evaluating whether FPR ≤ 2% might impact on the viro-immunological response in HIV-1 infected patients starting a first-line HAART. The analysis was performed on 305 HIV-1 B subtype infected drug-naïve patients who started their first-line HAART. Baseline FPR (%) values were stratified according to the following ranges: ≤ 2; 2-5; 5-10; 10-20; 20-60; >60. The impact of genotypically-inferred tropism on the time to achieve immunological reconstitution (a CD4 cell count gain from HAART initiation ≥ 150 cells/mm(3)) and on the time to achieve virological success (the first HIV-RNA measurement immunological reconstitution was overall 75.5%, and it was significantly lower for FPR ≤ 2 (54.1%) in comparison to other FPR ranks (78.8%, FPR 2-5; 77.5%, FPR 5-10; 71.7%, FPR 10-20; 81.8%, FPR 20-60; 75.1%, FPR >60; p = 0.008). The overall proportion of patients achieving virological success was 95.5% by 12 months of therapy. Multivariable Cox analyses showed that patients having pre-HAART FPR ≤ 2% had a significant lower relative adjusted hazard [95% C.I.] both to achieve immunological reconstitution (0.37 [0.20-0.71], p = 0.003) and to achieve virological success (0.50 [0.26-0.94], p = 0.031) than those with pre-HAART FPR >60%. Beyond the genotypically-inferred tropism determination, FPR ≤ 2% predicts both a poor immunological reconstitution and a lower virological response in drug-naïve patients who started their first-line therapy. This parameter could be useful to identify patients potentially with less chance of achieving adequate immunological reconstitution and virological undetectability.

  19. Visual consequences of electronic reader use: a pilot study.

    Maducdoc, Marlon M; Haider, Asghar; Nalbandian, Angèle; Youm, Julie H; Morgan, Payam V; Crow, Robert W


    With the increasing prevalence of electronic readers (e-readers) for vocational and professional uses, it is important to discover if there are visual consequences in the use of these products. There are no studies in the literature quantifying the incidence or severity of eyestrain, nor are there clinical characteristics that may predispose to these symptoms with e-reader use. The primary objective of this pilot study was to assess the degree of eyestrain associated with e-reader use compared to traditional paper format. The secondary outcomes of this study were to assess the rate of eyestrain associated with e-reader use and identify any clinical characteristics that may be associated with the development of eyestrain. Forty-four students were randomly assigned to study (e-reader iPAD) and control (print) groups. Participant posture, luminosity of the room, and reading distance from reading device were measured during a 1-h session for both groups. At the end of the session, questionnaires were administered to determine symptoms. Significantly higher rates of eyestrain (p = 0.008) and irritation (p = 0.011) were found among the iPAD study group as compared to the print 'control' group. The study group was also 4.9 times more likely to report severe eyestrain (95 % CI [1.4, 16.9]). No clinical characteristics predisposing to eyestrain could be identified. These findings conclude that reading on e-readers may induce increased levels of irritation and eyestrain. Predisposing factors, etiology, and potential remedial interventions remain to be determined.

  20. Journeys toward Textual Relevance: Male Readers of Color and the Significance of Malcolm X and Harry Potter

    Sciurba, Katie


    This article combines interview data from a group of boys of color at an urban single-sex school and content analysis of "The Autobiography of Malcolm X" and "Harry Potter and the Sorcerer's Stone" to demonstrate the complexities of readers' responses to literature. Textual relevance, or the ability to construct personal…

  1. An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (exubera) with meformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea: response to mikhail and cope

    Barnett, Anthony H.; Dreyer, Manfred; Lange, Peter


    OBJECTIVE: To compare the efficacy and safety profile of adding inhaled human insulin (INH; Exubera) or metformin to sulfonylurea monotherapy in patients with poorly controlled type 2 diabetes. RESEARCH DESIGN AND METHODS: We performed an open-label, parallel, 24-week, multicenter trial. At week -1......: In patients with type 2 diabetes poorly controlled on a sulfonylurea (A1C >9.5%), the addition of premeal INH significantly improves glycemic control compared with adjunctive metformin and is well tolerated....

  2. The changing European family: lessons for the American reader.

    Cherlin, A; Furstenberg Ff


    The 7 chapters in this journal discuss the European family, including families in Britain, the Federal Republic of Germany, France, the German Democratic Republic, Italy, and Sweden. The authors feel that observers in the US sometimes resort to peculiarly American explanations (the budget deficit, changes in welfare benefits) to account for recent trends in marriage and fertility. The articles in this issue demonstrate that the pattern of post-WWII family change has been generally similar in North America, Western Europe, and even part of Eastern Europe, suggesting that more global rather than particular national explanations need to be sought. The post-WWII years can be divided into 2 periods: 1) the period from 1945 to 1965 that brought the unexpected marriage rush and baby boom, and 2) the period from 1965 to the present that brought a reversal of those trends in the form of later marriage, a great increase in nonmarital cohabitation, a large rise in divorce, and a sharp fall in fertility to below the replacement level. The similarity of these large-scale trends in North America and Western Europe is striking. The US is most like Britain and, beyond Europe, Canada, and Australia, suggesting that influence of the common culture of the English-speaking Western world. Yet the US has, and probably always has had, higher rates of fertility, marriage, and divorce than most Western European nations. The proportion of single-parent families is unusually large, even though some nations such as Sweden and East Germany have higher proportions of births to unmarried but cohabiting women. The level of cohabitation in the US, although greatly increased, is still moderate by European standards. Concern over the burden of government support for the elderly already has prompted changes in the Social Security program. The ability to support programs for children and for poor families is being questioned, even though the level of government support for the family is relatively low

  3. CT colonography: effect of experience and training on reader performance

    Taylor, Stuart A.; Burling, David; Morley, Simon; Bartram, Clive I.; Halligan, Steve; Bassett, Paul; Atkin, Wendy


    The purpose of this paper was to investigate the effect of radiologist experience and increasing exposure to CT colonography on reader performance. Three radiologists of differing general experience (consultant, research fellow, trainee) independently analysed 100 CT colonographic datasets. Readers had no prior experience of CT colonography and received feedback and training after the first 50 cases from an independent experienced radiologist. Diagnostic performance and reporting times were compared for the first and second 50 datasets and compared with the results of a radiologist experienced in CT colonography. Before training only the consultant reader achieved statistical equivalence with the reference standard for detection of larger polyps. After training, detection rates ranged between 25 and 58% for larger polyps. Only the trainee significantly improved after training (P=0.007), with performance of other readers unchanged or even worse. Reporting times following training were reduced significantly for the consultant and fellow (P<0.001 and P=0.03, respectively), but increased for the trainee (P<0.001). In comparison to the consultant reader, the odds of detection of larger polyps was 0.36 (CI 0.16, 0.82) for the fellow and 0.36 (CI 0.14, 0.91) for the trainee. There is considerable variation in the ability to report CT colonography. Prior experience in gastrointestinal radiology is a distinct advantage. Competence cannot be assumed even after directed training via a database of 50 cases. (orig.)

  4. Development of optically stimulated luminescence reader systems in BARC

    Kulkarni, M.S.


    BARC has very vast experience in the development of thermoluminescence (TL) reader systems both for routine personnel monitoring and research application. However, optically stimulated luminescence (OSL) related instrumentation is a recent development in BARC. The increasing popularity of OSL technique in the radiation dosimetry applications in the recent past has driven investigation and developmental programme in the OSL measurement facilities at BARC. As the consequence of the efforts directed towards the indigenous development of OSL reader system, OSL readers with various readout modes like continuous wave (CW) OSL mode, linear intensity modulated OSL (LM-OSL), pulsed OSL (POSL) have been developed. In addition to these conventional modes of operation a novel non-linear OSL mode (NL-OSL) has also been developed for the OSL measurements. This paper reviews the details of the development of OSL reader system including experience with high intensity blue/green LED stimulation light source and detection system. Also discussed are recently developed versatile integrated TL/OSL reader systems for TL and OSL measurements. (author)

  5. Semantic, syntactic, and phonological processing of written words in adult developmental dyslexic readers: an event-related brain potential study

    Johannes Sönke


    Full Text Available Abstract Background The present study used event-related brain potentials to investigate semantic, phonological and syntactic processes in adult German dyslexic and normal readers in a word reading task. Pairs of German words were presented one word at a time. Subjects had to perform a semantic judgment task (house – window; are they semantically related?, a rhyme judgment task (house – mouse; do they rhyme? and a gender judgment task (das – Haus [the – house]; is the gender correct? [in German, house has a neutral gender: das Haus]. Results Normal readers responded faster compared to dyslexic readers in all three tasks. Onset latencies of the N400 component were delayed in dyslexic readers in the rhyme judgment and in the gender judgment task, but not in the semantic judgment task. N400 and the anterior negativity peak amplitudes did not differ between the two groups. However, the N400 persisted longer in the dyslexic group in the rhyme judgment and in the semantic judgment tasks. Conclusion These findings indicate that dyslexics are phonologically impaired (delayed N400 in the rhyme judgment task but that they also have difficulties in other, non-phonological aspects of reading (longer response times, longer persistence of the N400. Specifically, semantic and syntactic integration seem to require more effort for dyslexic readers and take longer irrespective of the reading task that has to be performed.

  6. A study on the development of an infographic reader questionnaire and reader opinions

    Yıldırım Serkan


    Full Text Available Educational materials are commonly used to assist with communication during learning. One of the ways to determine the use of educational materials and their contribution to the learning process is to ask students for their opinions. Student opinions provide useful information regarding various objectives such as making both the learning process and resources more effective, bringing about the necessary improvements and organising the teaching process. In this study, we developed a questionnaire for determining the opinions of information graphics (infographics readers on information graphics prepared for teaching purposes. This study was conducted in the fall semester of the 2013-2014 academic year with the participation of 59 students from the Department of Computer and Instructional Technologies Education of the Kazım Karabekir Faculty of Education. The students were provided with a questionnaire consisting of 29 items that inquired their opinions on infographics. The collected data were assessed using Principal Component Analysis. Based on the analysis results, a second questionnaire consisting of 23 items and six factors (Learnability, Selection Preferences, Sharing, Basic Presentation Structure, Memorability, and Role in the Learning Process was developed. According to the study results, the students considered infographics as highly instructive, and described that they help ensure a more lasting learning experience.

  7. How to diagnose any type of TLD Reader?

    Rodriguez, Manuel Lopez; Garcia, Jose A. Tamayo; Gil, Alex Vergara; Lores, Stefan Gutierrez; Acosta, Andry Romero; Villanueva, Gilberto Alonso


    The acquisition of know how of practical experiences obtained in the repair and maintenance of readers TLD RADOS for five years of work and the request by the International Atomic Energy for signing new Research Contracts (CRP), made possible the CRP 13328, in which the specialist is committed in the course of a year, to deliver educational software in order to train personnel associated with the operation of the TLD readers RADOS. Due to the importance of continuous transfer of knowledge for new generations of technicians and specialists who join our laboratories, the idea came when the first interactive CD that grouped 19 videos, divided into three blocks was ready: learning, repair and maintenance; it was suggested to expand the training for any TLD reader. Thus a much more complete than the first version package emerged. 7 cases were subsequently published in an IAEA TECDOC, 1599 were included

  8. Cognitive Processes in Discourse Comprehension: Passive Processes, Reader-Initiated Processes, and Evolving Mental Representations

    van den Broek, Paul; Helder, Anne


    As readers move through a text, they engage in various types of processes that, if all goes well, result in a mental representation that captures their interpretation of the text. With each new text segment the reader engages in passive and, at times, reader-initiated processes. These processes are strongly influenced by the readers'…

  9. Struggling Readers: Assessment and Instruction in Grades K-6. Solving Problems in the Teaching of Literacy.

    Balajthy, Ernest; Lipa-Wade, Sally

    This book focuses on three distinct types of struggling readers that teachers will instantly recognize from their own classrooms--the "Catch-On Reader," the "Catch-Up Reader," and the "Stalled Reader." The book provides detailed case studies which bring to life the specific problems these students are likely to face…

  10. Using Twitter to Teach Reader-Oriented Biblical Interpretation: "Tweading" the Gospel of Mark

    Williamson, Robert, Jr.


    Twitter offers an engaging way to introduce students to reader-oriented interpretation of the Bible. The exercise described here introduces students to the idea that the reader has a role in the production of a text's meaning, which thus varies from reader to reader. Twitter enables us to capture the real-time thoughts of a variety of…

  11. When high-capacity readers slow down and low-capacity readers speed up: Working memory and locality effects

    Bruno eNicenboim


    Full Text Available We examined the effects of argument-head distance in SVO and SOV languages (Spanish and German, while taking into account readers’ working memory capacity and controlling for expectation (Levy, 2008 and other factors. We predicted only locality effects, that is, a slow-down produced by increased dependency distance (Gibson, 2000; Lewis & Vasishth, 2005. Furthermore, we expected stronger locality effects for readers with low working memory capacity. Contrary to our predictions, low-capacity readers showed faster reading with increased distance, while high-capacity readers showed locality effects. We suggest that while the locality effects are compatible with memory-based explanations, the speedup of low-capacity readers can be explained by an increased probability of retrieval failure. We present a computational model based on ACT-R built under the previous assumptions, which is able to give a qualitative account for the present data and can be tested in future research. Our results suggest that in some cases, interpreting longer RTs as indexing increased processing difficulty and shorter RTs as facilitation may be too simplistic: The same increase in processing difficulty may lead to slowdowns in high-capacity readers and speedups in low-capacity ones. Ignoring individual level capacity differences when investigating locality effects may lead to misleading conclusions.

  12. Using Randomized Clinical Trials to Determine the Impact of Reading Intervention on Struggling Adolescent Readers: Reports of Research from Five Nationally Funded Striving Readers Grants

    Loadman, William; Sprague, Kim; Hamilton, Jennifer; Coffey, Deb; Faddis, Bonnie


    In 2005, the U.S. Department of Education awarded eight Striving Readers grants to projects around the country. The goal of Striving Readers is to improve literacy skills and achievement for struggling readers in middle and high school and to increase the research base using randomized clinical research to address improvement in adolescent…

  13. Are the energy poor also income poor? Evidence from India

    Khandker, Shahidur R.; Barnes, Douglas F.; Samad, Hussain A.


    The energy poverty line is defined as the threshold point at which energy consumption begins to rise with increases in household income. This approach is applied to cross-sectional data from a comprehensive 2005 household survey representative of both urban and rural India. The objective is to determine if the energy poor are also income poor and whether and how energy policies help reduce energy poverty, independent of income. The findings suggest that in rural areas some 57% of households are energy poor, versus 22% that are income poor. But in urban areas the energy poverty rate is 28% compared to 20% that are income poor. That is, energy policies are expected to play some roles in mitigating energy poverty. We find that reducing energy poverty requires not only support for rural electrification, but also more use of modern cooking fuels such as LPG. While income growth matters, a combination of energy related programs can play an independent and substantial role in reducing energy poverty. - Highlights: ► This paper applies a new approach to measuring energy poverty to rural and urban India. ► It also compares and contrasts income poverty with energy poverty in the context of India. ► Findings suggest that income poverty tracks energy poverty in urban India, but not in rural India. ► Income growth is very important in reducing energy poverty. ► In addition, access to and reliability of modern sources (electricity, LPG) are also helpful.

  14. Is American business working for the poor?

    Bane, M J; Ellwood, D T


    At first glance, poverty seems to have little to do with business. When most people--managers included--think about poverty, they assume that people are poor because they are isolated from the mainstream economy, not productive participants in it. But according to Harvard University professors Mary Jo Bane and David Ellwood, this is a misleading image of the true face of poverty in the United States today. Most poor adults--and a full 90% of poor children--live in families where work is the norm, not the exception. Poor people often work or want to work. But at the low-wage end of the American economy, having a job is no guarantee of avoiding poverty. Poverty is a business issue, then, because the American poor are part of the American work force. And this poses a problem for managers. In a more competitive and fast-changing economic environment, the performance of companies increasingly depends on the capabilities of their employees. In response to this human-resource challenge, more and more managers are embracing the language of "empowerment". And yet how can low-wage employees believe empowerment when their experience of work is, quite literally, impoverishment? It is unlikely that American companies can create the work force of the future with the poverty policies of the past. Fortunately, there are some simple policy mechanisms that can assist the working poor without putting an undue burden on business. Enacting them, however, requires managers to see poverty policy as one part of a national human-resource strategy that links the strategic concerns of companies to a broad social agenda.

  15. Preliteracy signatures of poor-reading abilities in resting-state EEG

    Giuseppina eSchiavone


    Full Text Available The hereditary character of dyslexia suggests the presence of putative underlying neural anomalies already in preliterate age. Here, we investigated whether early neurophysiological correlates of future reading difficulties—a hallmark of dyslexia—could be identified in the resting-state EEG of preliterate children. The children in this study were recruited at birth and classified on the basis of parents’ performance on reading tests to be at-risk of becoming poor readers (n = 48 or not (n = 14. Eyes-open rest EEG was measured at the age of 3 years, and the at-risk children were divided into fluent readers (n = 24 and non-fluent readers (n = 24 after reading assessment at their third grade of school. We found that fluent readers and non-fluent readers differed in normalized spectral amplitude. Non-fluent readers were characterized by lower amplitude in the delta-1 frequency band (0.5–2 Hz and higher amplitude in the alpha-1 band (6–8 Hz in multiple scalp regions compared to control and at-risk fluent readers. Interestingly, across groups these EEG biomarkers correlated with several behavioral test scores measured in the third grade. Specifically, the performance on reading fluency, phonological and orthographic tasks and rapid automatized naming task correlated positively with delta-1 and negatively with alpha-1. Together, our results suggest that combining family-risk status, neurophysiological testing and behavioral test scores in a longitudinal setting may help uncover physiological mechanisms implicated with neurodevelopmental disorders such as the predisposition to reading disabilities.

  16. The Role of Hand Dominance in Beginning Braille Readers

    Wright, Tessa


    In this article, the author examines the role of "hand dominance" in beginning braille readers. "Hand dominance" refers to whether an individual is "right handed" or "left handed." The data for these analyses were taken from the Alphabetic Braille and Contracted Braille Study (ABC Braille Study). The ABC Braille Study was a five-year nonrandomized…

  17. Moral Choices in Contemporary Society: A Courses by Newspaper Reader.

    Rieff, Philip, Ed.; Finkle, Isaac, Ed.

    This reader, which contains 135 primary source readings about morality, is one of several college-level instructional materials developed to supplement a nationwide newspaper course on moral issues in contemporary society. The authors represent a diverse group including theologians, psychologists, politicians, professional athletes, lawyers, and…

  18. 3,000 Paper Cranes: Children's Literature for Remedial Readers.

    Shumaker, Marjorie P.; Shumaker, Ronald C.


    Describes how the educational experience of sixth grade remedial readers was revitalized and enriched through a project that grew out of reading "Sadako and the Thousand Paper Cranes." Suggests using "real" books (literature) to liberate remedial students from skill drills and reading games. (NH)

  19. The Fluid Reading Primer: Animated Decoding Support for Emergent Readers.

    Zellweger, Polle T.; Mackinlay, Jock D.

    A prototype application called the Fluid Reading Primer was developed to help emergent readers with the process of decoding written words into their spoken forms. The Fluid Reading Primer is part of a larger research project called Fluid Documents, which is exploring the use of interactive animation of typography to show additional information in…

  20. Scaffolding or Distracting: CD-ROM Storybooks and Young Readers

    Pearman, Cathy J.; Chang, Ching-Wen


    CD-ROM storybooks, often referred to as electronic texts, e-books, and interactive stories, are learning tools with supplemental features such as automatic reading of text, sound effects, word pronunciations, and graphic animations which support the development of reading skills and comprehension in beginning readers. Some CD-ROM storybooks also…

  1. English for Mass Communications and for Other Purposes-Readers ...

    This study was an investigation into the way readers perceive the use of English, for different purposes, and in particular, for mass communication in a second language setting. For this purpose, a simple questionnaire in form of the Likert rating scale was used to generate data. The study involved 337 respondents.

  2. Medical Readers' Theater: Relevance to Geriatrics Medical Education

    Shapiro, Johanna; Cho, Beverly


    Medical Readers' Theater (MRT) is an innovative and simple way of helping medical students to reflect on difficult-to-discuss topics in geriatrics medical education, such as aging stereotypes, disability and loss of independence, sexuality, assisted living, relationships with adult children, and end-of-life issues. The authors describe a required…

  3. ReaderBench: An Integrated Cohesion-Centered Framework

    Dascalu, Mihai; Stavarache, Lucia Larise; Dessus, Philippe; Trausan-Matu, Stefan; McNamara, Danielle S.; Bianco, Maryse


    Dascalu, M., Stavarache, L.L., Dessus, P., Trausan-Matu, S., McNamara, D.S., & Bianco, M. (2015). ReaderBench: An Integrated Cohesion-Centered Framework. In G. Conole, T. Klobucar, C. Rensing, J. Konert & É. Lavoué (Eds.), 10th European Conf. on Technology Enhanced Learning (pp. 505–508). Toledo,

  4. Child Readers and the Worlds of the Picture Book

    Baird, Adela; Laugharne, Janet; Maagerø, Eva; Tønnessen, Elise Seip


    Children as readers of picture books and the ways they respond to, and make meaning from, such texts are the focus of this article, which reports on a small-scale study undertaken in Norway and Wales, UK. The theoretical framing of the research draws on concepts of the multimodal ensemble in picture books and of the reading event as part of a…

  5. The Role of Reader in Felpo Filva, by Eva Furnari

    Ana Elvira L. Gebara


    Full Text Available In order to analyze the relationship between writer-reader and mediation of the text, it is necessary to identify the positions they occupy. Before the Internet, it was not common for the reader to approach the writer directly, except though letters. This virtual (but not digital contact is modelling to understand the reader’s relationship with the author because, in the written lines, he ends up indicating how he understands himself and the other – in a game of faces, understood in this work as Kerbrat-Orecchioni (2006 it characterizes in conversation. In this hyper-gender, without socio-historical restrictions or of categorization (MAINGUENEAU, 2010, there is a mandatory provision that constrains the sender to identify his position from the moment he chooses how to address the recipient. In these forms of treatment, the relationships of preservation or threat to the in the light of what is extended or made explicit in the treatment given to the theme of the letter to be outlined. This article aims to identify the concepts of the reader in the correspondence exchanged by the main characters, Charlô and Felpo, core of the development of the narrative (FURNARI, 2006. These concepts allow us to comprehend, in a discursive and dialogical perspective, which boundaries remain for the reader towards the text and which are outdated.

  6. Video Vortex reader II: moving images beyond YouTube

    Lovink, G.; Somers Miles, R.


    Video Vortex Reader II is the Institute of Network Cultures' second collection of texts that critically explore the rapidly changing landscape of online video and its use. With the success of YouTube ('2 billion views per day') and the rise of other online video sharing platforms, the moving image

  7. Dose reader of dosimetric foil; Czytnik dawki folii dozymetrycznej

    Machaj, B.; Strzalkowski, J.; Smolko, K.


    Read out the absorbance of a dosimetric foil is accomplished by two beam spectrophotometer. Such a solution makes possible the compensation of light source instabilities and ensures higher stability of the dose reader. The error of absorbance measurement caused by the instabilities does not exceed 0.0004 A. (author). 3 refs, 3 figs.

  8. Readers' opinion about English original articles in Ugeskrift for Laeger

    Nielsen, Jan; Rosberg, Hanne Mohr; Rosenberg, J.


    INTRODUCTION: The Danish Medical Association performed a survey together with TNS Gallup Denmark among the readers of Ugeskrift for Laeger (Journal of the Danish Medical Association). The main motivation for the questionnaire was to evaluate the acceptability of changing the publication language...

  9. Spongelike Acquisition of Sight Vocabulary in Beginning Readers?

    Stuart, Morag; Masterson, Jackie; Dixon, Maureen


    Investigates the relation between phonological awareness, sound-to-letter mapping knowledge, and printed word learning in novice five-year-old readers. Explores effects of visual memory and of teaching methods. Finds mental representations of printed words are more easily formed by beginners who are able to match at least some of the phonological…

  10. Dewitt Wallace-Reader's Digest Fund National Library Power Program.

    School Library Media Annual (SLMA), 1993


    Describes the National Library Power Program, a collaborative effort sponsored by the Dewitt Wallace-Reader's Digest Fund in cooperation with local education funds and public school districts that was designed to create public elementary and middle school library programs that are central to the education program of the school. (LRW)

  11. Guiding the Gifted Reader. ERIC Digest #E481.

    Halsted, Judith Wynn

    This digest offers guidelines in providing challenging reading opportunities for gifted students. Research findings concerning the characteristics of the gifted child as reader (e.g., they read earlier, better and more) are noted. Specific needs of gifted learners can be met by: using literature as a supplement to the readings in basal texts;…

  12. Prosodic Awareness and Punctuation Ability in Adult Readers

    Heggie, Lindsay; Wade-Woolley, Lesly


    We examined the relationship between two metalinguistic tasks: prosodic awareness and punctuation ability. Specifically, we investigated whether adults' ability to punctuate was related to the degree to which they are aware of and able to manipulate prosody in spoken language. English-speaking adult readers (n = 115) were administered a receptive…

  13. Selecting literature for beginner readers in South Africa

    Hibbert, Liesel


    Full Text Available This article explores complexities of choosing appropriate reading material which may provide maximum engagement for beginner readers in Southern Africa, with the aim of instilling a lifelong love of reading. The article presents a case in favour of literary criteria as base line for choices of reading material for beginner readers. Furthermore, the article outlines general characteristics of reading material for beginner readers, as well as specific criteria to be considered in the Southern African context, taking into account the linguistic diversity which exists in formal education and the vast literacy backlog in the region. Furthermore, it is argued that translated children’s stories should ideally be adapted rather than literally translated, in order to meet the requirements of what is universally regarded as good children’s literature for beginner readers. A culture of reading can only be instilled by adhering to the following criteria, i.e. ensuring affective engagement, maximum meaning-making potential, delight, the engagement of the imagination for the purposes of developing the creative mind, and strong identification with the material for the purposes of developing a sense of agency.

  14. Supporting Struggling Readers in Secondary School Science Classes

    Roberts, Kelly D.; Takahashi, Kiriko; Park, Hye-Jin; Stodden, Robert A.


    Many secondary school students struggle to read complex expository text such as science textbooks. This article provides step-by-step guidance on how to foster expository reading for struggling readers in secondary school science classes. Two strategies are introduced: Text-to-Speech (TTS) Software as a reading compensatory strategy and the…

  15. The influence of psychological type preferences on readers trying To ...

    Around 65% could do so ('imaginers') and 35% could not. The likelihood of being an imaginer was higher among (i) women than among men, (ii) those who preferred intuition to sensing or feeling to thinking, and (iii) those who were most charismatically active. Readers with intuition as their dominant function were most ...

  16. The Impact of Open Licensing on the Early Reader Ecosystem

    Butcher, Neil; Hoosen, Sarah; Levey, Lisbeth; Moore, Derek


    The Impact of Open Licensing on the Early Reader Ecosystem examines how to use open licensing to promote quality learning resources for young children that are relevant and interesting. Research in early reading tends to focus on traditional publishing value and supply chains, without taking much consideration of new approaches and solutions…

  17. Technology for the Struggling Reader: Free and Easily Accessible Resources

    Berkeley, Sheri; Lindstrom, Jennifer H.


    A fundamental problem for many struggling readers, their parents, and their teachers is that there are few benchmarks to guide decision making about assistive technological supports when the nature of a disability is cognitive (e.g., specific learning disability, SLD) rather than physical. However, resources such as the National Center on…

  18. ELISA reader does not interfere by mobile phone radiofrequency radiation

    Seyyed Mohammad Javad Mortazavi


    Conclusion: This study showed that ELISA reader does not interfere by mobile phone RF radiation at a closed contact (less than 5 cm distance. However, we recommend that medical institutions discuss these issues in the context of their specific use of technologies and frame a policy that is clear and straightforward to guide staff, patients, and visitors.

  19. Learning Strategies in Proficient and Less Proficient Readers in Medicine

    Nemati, Majid; Nodoushan, Mohammad Ali Salmani; Ashrafzadeh, Anis


    The current study aimed to diagnose the probable significant differences in the use of language learning strategies among medical-text readers of opposite sex from different levels of proficiency. 120 (N = 120) participants were randomly selected from Azad Medical University of Mashhad: 60 medical students (age range 23-25; 30 = male and 30 =…

  20. Solar Energy Education. Reader, Part II. Sun story. [Includes glossary


    Magazine articles which focus on the subject of solar energy are presented. The booklet prepared is the second of a four part series of the Solar Energy Reader. Excerpts from the magazines include the history of solar energy, mythology and tales, and selected poetry on the sun. A glossary of energy related terms is included. (BCS)

  1. Kindling: The Amazon e-Reader as an Educational Tool

    Brezicki, Colin


    The revolutionary electronic reading device, Amazon's Kindle, is already obsolete. Such is the breakneck speed of technology that the machine touted to spell the death of printed books is already heading for the scrap heap, replaced by e-readers like the iPad that access the Internet, make phone calls, download movies, and connect users with all…

  2. The Development of Visual Search Strategies in Biscriptal Readers.

    Liow, Susan Rikard; Green, David; Tam, Melissa


    To test whether cognitive processing in bilingual depends on script combinations and language proficiency, this study investigated the development of alphabetic and logographic visual search strategies in two kinds of biscriptals: (1) Malay-English and (2) Chinese-English readers. Results support the view that there are script implications of…

  3. Trends in Teacher Certification: Equipping Teachers to Prepare Proficient Readers

    Rowland, Julie


    Ensuring that students are reading proficiently by third grade is a key component of keeping students on track to graduate high school and pursue college and careers. Because of the magnitude of this academic milestone, states typically pursue policies that promote early identification and intervention for struggling readers. However, teachers are…

  4. A new microcontroller-based RADFET dosimeter reader

    Vasović, Nikola D.; Ristić, Goran S.


    A new reader for radiation dose measurements using RADFET (pMOSFET) dosemeters has been developed. The threshold voltage (V T ) of the pMOSFETs is measured using a “one-point” method that determines V T as the gate voltage for a given drain current. Using V T , the absorbed dose, which is directly proportional to the threshold voltage shift, is calculated. The reader is based on a low cost 8-bit PIC 18F4520 microcontroller (MCU), and works independently of a personal computer, uses a touch screen and stores the data in microcontroller memory. Good agreement in threshold voltage values, obtained using a high-quality source-measure unit and the reader, was obtained. In addition, the reader can be used for threshold voltage measurement with other types of MOSFETs, especially in long duration experiments, as well as for the real-time measurements in radiotherapy, either as an autonomous system or integrated in a larger monitoring configuration.

  5. Students Attendance Management System Based On RFID And Fingerprint Reader

    Moth Moth Myint Thein


    Full Text Available Abstract Today students class attendance is become more important part for any organizationsinstitutions. The conventional method of taking attendance by calling names or signing on paper is very time consuming and insecure hence inefficient. This paper presents the manual students attendance management into computerized system for convenience or data reliability. So the system is developed by the integration of ubiquitous computing systems into classroom for managing the students attendance using RFID and fingerprint reader. The system is designed to implement an attendance management system based on RFID and fingerprint reader which students need to use their student identification card ID and their finger ID to success the attendance where only authentic student can be recorded the attendance during the class. In this system passive RFID tag and reader pairs are used to register the student ID cards individually and fingerprint reader is used for attendance. This system takes attendance electronically with the help of the RFID and finger print device and the records of the attendance are stored in a database. Students roll call percentages and their details are easily seenvia Graphical User Interface GUI. This system will have the required databases for students attendance teachers subjects and students details. This application is implemented by Microsoft Visual Studio and Microsoft SQL Server as IDE. C language is used to implement this system.

  6. SSR: What's in "School Science Review" for "PSR" Readers?

    Lakin, Liz


    This article summarises ideas and developments in teaching and learning in science of relevance to "Primary Science Review" ("PSR") readers from three recent issues (309, 310, and 311) of "School Science Review" ("SSR"), the ASE journal for science education 11-19. The themes running through these are: ICT, the implications for science education…

  7. Empowering Adolescent Readers: Intertextuality in Three Novels by David Almond

    Latham, Don


    In "Skellig," "Kit's Wilderness," and "Clay", David Almond employs various types of intertextuality to enrich his narratives. Through the use of allusion, adaptation, collage, and mise-en-abyme, he encourages his adolescent readers to seek out precursor texts and to consider the interrelationships between these texts and his own. By so doing, he…

  8. Building the Foundation for Close Reading with Developing Readers

    Baker, Sheila F.; McEnery, Lillian


    Close Reading utilizes several strategies to help readers think more critically about a text. Close reading can be performed within the context of shared readings, read-alouds by the teacher, literature discussion groups, and guided reading groups. Students attempting to more closely read difficult texts may benefit from technologies and platforms…

  9. The struggling reader: Identifying and addressing reading problems successfully at an early stage

    Le Cordeur, Michael


    Full Text Available The standard of reading of learners in the intermediate phase is cause for considerable concern. In this article, the intermediate phase refers to grades 4, 5 and 6 (roughly ages 10 – 12. According to the 2008 Evaluation Assessment Tests for Reading, only 15% of learners in Grade 6 achieved the required literacy level. Clearly, reading achievement is a problem in South Africa. Although approximately 4% of any given population experience neurological reading problems, the focus of this article is on the significant number of learners in the intermediate phase who experience reading problems and the generic causes of reading problems for learners in general. The intent is to alert teachers and parents to the characteristics of a struggling reader so that the problem can be identified and addressed early. Firstly, ways in which learning problems are manifested are described. Secondly, a discussion of various types of reading problems, of which four, namely poor reading comprehension, inadequate reading fluency, a lack of vocabulary and a negative attitude towards reading, are discussed in depth. Strategies for struggling readers are presented and recommendations are made. The conclusion is that learners who experience reading problems can learn to read successfully when given the necessary support.

  10. Thomas Hardy and His Readers: Contradictions of the Rebellious Serial Writer

    Adelina Sánchez Espinosa


    Full Text Available This contribution explores the relationship between Thomas Hardy and his contemporary readers from The Poor Man and the Lady, his first, unpublished, novel, to The Well- Beloved, his last one. It discovers a writer split into two, with Hardy, the artist, striving to cohabitate with Hardy-the serial writer for the three decades his career as a novelist lasted. In order to fully appreciate Hardy's novels as they have reached us nowadays, after the 1912 Wessex edition, we should focus on the contradictions between their initial manuscripts, their edited versions for the family magazines and their final reconstructions into volume forms. Although Hardy certainly wanted quick success with the Victorian masses he never let go of his "higher aspirations" to be received differently by a more select readership, even if this alternative reading had to be done between the lines at a later stage.

  11. Mind the Gap: Bridging the Divide between Non-Readers and Lifelong Readers with Hi-Lo Books

    Gleason, Carrie


    In the past few years, there has been increasing demand from school librarians for books for "reluctant readers"--despite the impressive offering of children's literature published each year and the success of blockbuster series like "Harry Potter, Diary of a Wimpy Kid, Twilight," and "Hunger Games," among others. This is also in addition to all…

  12. Distinguishing between Poor/Dysfunctional Parenting and Child Emotional Maltreatment

    Wolfe, David A.; McIsaac, Caroline


    Objective: This paper was intended to distinguish between poor parenting and child emotional maltreatment (CEM), to inform child welfare and public health policymakers of the need for differentiated responses. Methods: Scientific literature was integrated with current practice and assumptions relating to poor/dysfunctional parenting and child…


    New Win User

    registrations for the poor and low-literate / corporate social responsibility); ..... legal textbooks, statutory texts, case law texts, customary texts (from a largely ...... by speaking directly to the prosecutor, or an academic who specialises in ethics.

  14. A TLD reader for wide range in situ dose measurement

    Deme, S; Apathy, I.; Bodnar, L.; Csoeke, A.; Hejja, I.


    A portable thermoluminescent dosemeter reader suitable for reading at the site of exposure is described. The instrument consists of a glass bulb containing the CaSO 4 :Dy thermoluminescent material laminated to the surface of an electrically heated resistive metal plate. The bulb is encapsulated in a cylindrical, pen-like metal holder made of aluminium. A one-wire-port integrated electronic programmable memory chip mounted inside the holder contains the identification code and the individual calibration parameters of the dosemeter. The aperture of the holder is normally covered by a stainless steel tube to protect the bulb from light and mechanical shocks. The tube slips backwards automatically when the dosemeter is inserted into the reader. The system is used by the Hungarian nuclear power plant. (M.D.)

  15. Social Imaginary in web advertising of e-readers

    Silvina Marcela Angelozzi


    Full Text Available This paper explores the imaginary meanings that appear in the advertising discourses on e-book reading devices commonly known as e-readers. It starts from the assumption that imaginary meanings are associated with both: the imaginary associated to digital technologies (Cabrera, 2006, 2011 and to the imaginary of "order of books" (Chartier, 2000, 2005. In order to carry out the exploration, the advertising discourses in the homepages of three cases are analized: The Amazon Kindle, Kobo and MovistarBq brands. The conclusion is that e-readers are devices that participate of the imaginary of the digital technologies as other devices in the complex of digital technologies in everyday life, and also refers strongly to the imaginary meanings related to printed books.


    Marleide Anchieta de Lima


    Full Text Available In the poetry of Manuel Gusmão, the reader is invited to actively partici­pate in writing and reading scenes. To the poet-critic, the act of reading, understood as emancipatory and political practice, is sharing the aesthe­tic experience and the development of our sensitive-cognitive instances, beyond the world learning outside and inside the text. In this sense, our article aims to examine the critical reader configuration from three aspects present in that poetry – act of co-motion, epistemological construction and erratic tissue habitation. With this perspective, we turn to the theoretical­-critical of Roland Bathes, Jacques Rancière and Eduardo Prado Coelho.

  17. How does typeface familiarity affect reading performance and reader preference?

    Beier, Sofie


    the reading speed and preferences of participants. Participants were tested twice with common and uncommon letter shapes, once before and once after spending 20 minutes reading a story with the font. The results indicate that the exposure period has an effect on the speed of reading, but the uncommon letter...... shapes did not. Readers did not like the uncommon letter shapes. This has implications for the selection of type and the design of future typefaces....

  18. The Use of English Collocations in Reader's Digest

    Sinaga, Yudita Putri Nurani; Sinaga, Lidiman Sahat Martua


    This descriptive qualitative study is aimed at identifying and describing the types of free collocations found in the articles of Reader's Digest. By taking a sample of ten articles from different months for each year since 2003 up to 2012, it was found all the four productive free collocations were in the data. Type 4 (Determiner + Adjective + Noun) was the dominant type (53.92 %). This was possible because the adjective in the pattern included the present participle and past participle of v...

  19. Featured Article: Genotation: Actionable knowledge for the scientific reader.

    Nagahawatte, Panduka; Willis, Ethan; Sakauye, Mark; Jose, Rony; Chen, Hao; Davis, Robert L


    We present an article viewer application that allows a scientific reader to easily discover and share knowledge by linking genomics-related concepts to knowledge of disparate biomedical databases. High-throughput data streams generated by technical advancements have contributed to scientific knowledge discovery at an unprecedented rate. Biomedical Informaticists have created a diverse set of databases to store and retrieve the discovered knowledge. The diversity and abundance of such resources present biomedical researchers a challenge with knowledge discovery. These challenges highlight a need for a better informatics solution. We use a text mining algorithm, Genomine, to identify gene symbols from the text of a journal article. The identified symbols are supplemented with information from the GenoDB knowledgebase. Self-updating GenoDB contains information from NCBI Gene, Clinvar, Medgen, dbSNP, KEGG, PharmGKB, Uniprot, and Hugo Gene databases. The journal viewer is a web application accessible via a web browser. The features described herein are accessible on The Genomine algorithm identifies gene symbols with an accuracy shown by .65 F-Score. GenoDB currently contains information regarding 59,905 gene symbols, 5633 drug-gene relationships, 5981 gene-disease relationships, and 713 pathways. This application provides scientific readers with actionable knowledge related to concepts of a manuscript. The reader will be able to save and share supplements to be visualized in a graphical manner. This provides convenient access to details of complex biological phenomena, enabling biomedical researchers to generate novel hypothesis to further our knowledge in human health. This manuscript presents a novel application that integrates genomic, proteomic, and pharmacogenomic information to supplement content of a biomedical manuscript and enable readers to automatically discover actionable knowledge. © 2016 by the Society for Experimental Biology and

  20. ELISA reader does not interfere by mobile phone radiofrequency radiation

    Mortazavi, Seyyed Mohammad Javad; Baradaran-Ghahfarokhi, Hamid Reza; Abdi, Mohammad Reza; Baradaran-Ghahfarokhi, Milad; Mostafavi, Nayyer Sadat; Mahmoudi, Golshan; Berenjkoub, Nafiseh; Akmali, Zahra; Hossein-Beigi, Fahimeh; Arsang, Vajiheh


    Background: The increasing number of mobile phones can physically cause electromagnetic interference (EMI) in medical environments; can also cause errors in immunoassays in laboratories. The ELISA readers are widely used as a useful diagnostic tool for Enzymun colorimetric assay in medicine. The aim of this study was to investigate whether the ELISA reader could be interfered by the exposure to the 900 MHz cell phones in the laboratory. Materials and Methods: Human serum samples were collected from 14 healthy donors (9 women and 5 men) and each sample was divided into four aliquots and was placed into four batches for the in-vitro quantitative determination of human chorionic gonadotropin (hCG). During colorimetric reading of the first, second, and third batches, the ELISA reader (Stat Fax 2100, Awareness Technology, Inc., USA) was exposed to 0.5, 1.0, and 2.0 W exposure of 900 MHz radiation, respectively. For the forth batch (control group), no radiation was applied. All experiments were performed comparing ELISA read out results of the I, II, and III batches with the control batch, using the Wilcoxon test with criterion level of P = 0.050. Results: The final scores in the exposed batches I, II, and III were not statistically significant relative to the control batch (P > 0.05). The results showed that 900 MHz radiation exposure did not alter the ELISA measured levels of hCG hormone in I (P = 0.219), II (P = 0.909), and III (P = 0.056) batches compared to the control batch. Conclusion: This study showed that ELISA reader does not interfere by mobile phone RF radiation at a closed contact (less than 5 cm distance). However, we recommend that medical institutions discuss these issues in the context of their specific use of technologies and frame a policy that is clear and straightforward to guide staff, patients, and visitors. PMID:27376040

  1. Solar Energy Education. Reader, Part IV. Sun schooling


    A collection of magazine articles which focus on solar energy is presented. This is the final book of the four part series of the Solar Energy Reader. The articles include brief discussions on energy topics such as the sun, ocean energy, methane gas from cow manure, and solar homes. Instructions for constructing a sundial and a solar stove are also included. A glossary of energy related terms is provided. (BCS)

  2. Lesion type and reader experience affect the diagnostic accuracy of breast MRI: A multiple reader ROC study

    Baltzer, Pascal A.T., E-mail: [Department of Biomedical Imaging and Imge-guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna (Austria); Kaiser, Werner Alois [Department of Diagnostic and Interventional Radiology, University Hospital Jena, Erlanger Allee 101, 07740 Jena (Germany); Dietzel, Matthias, E-mail: [Department of Neuroradiology, University Hospital Erlangen, Schwabachanlage 6, 91054 Erlangen (Germany)


    Highlights: • The main findings of our study are, that reader experience and lesion type (i.e., mass versus non-mass enhancement) are independent predictors of the diagnostic accuracy of breast MRI. • Specifically, benign and malignant non-mass lesions cannot be differentiated with sufficient accuracy, especially if readers are not experienced. • We conclude that future research in breast MRI should focus on non-mass lesions, as these are the problem makers in modern breast MRI. - Abstract: Purpose: To evaluate the influence of lesion type (mass versus non-mass) and reader experience on the diagnostic performance of breast MRI (BMRI) in a non-screening setting. Materials and methods: Consecutive patients (mean age, 55 ± 12 years) with breast lesions that were verified by biopsy or surgery, and who had had BMRI as part of their diagnostic workup, were eligible for this retrospective single-center study. Cancers diagnosed by biopsy before BMRI were excluded to eliminate biological and interpretation bias due to biopsy or chemotherapy effects (n = 103). Six blinded readers (experience level, high (HE, n = 2); intermediate (IE, n = 2); and low (LE, n = 2)) evaluated all examinations and assigned independent MRI BI-RADS ratings. Lesion type (mass, non-mass, focal) was noted. Receiver operating characteristics (ROC) and logistic regression analysis was performed to compare diagnostic accuracies. Results: There were 259 histologically verified lesions (123 malignant, 136 benign) investigated. There were 169 mass (103 malignant, 66 benign) and 48 non-mass lesions (19 malignant, 29 benign). Another 42 lesions that met the inclusion criteria were biopsied due to conventional findings (i.e., microcalcifications, architectural distortions), but did not enhance on MRI (41 benign, one DCIS). ROC analysis revealed a total area under the curve (AUC) between 0.834 (LE) and 0.935 (HI). Logistic regression identified a significant effect of non-mass lesions (P < 0.0001) and

  3. STARtorialist: Astronomy Fashion & Culture Blog and Reader Survey Results

    Ash, Summer; Rice, Emily L.; Jarreau, Paige B.


    STARtorialist ( is a Tumblr-based blog that curates the proliferation of "Astro Fashion" - clothing accessories, decor, and more - with the goal of celebrating the beauty of the universe and highlighting the science behind the astronomical imagery. Since launching in January 2013, we have written over 1000 unique posts about everything from handmade and boutique products to mass-produced commercial items to haute couture seen on fashion runways. Each blog post features images and descriptions of the products with links to the original astronomical images or other relevant science content. We also feature profiles of astronomers, scientists, students, and communicators wearing, making, or decorating with "startorial" items. Our most popular posts accumulate hundreds or thousands of notes (faves or reblogs, in Tumblr parlance), and one post has nearly 150,000 notes. In our second year, we have grown from 1,000 to just shy of 20,000 followers on Tumblr, with an increased audience on Twitter, Instagram, and Facebook as well. We present preliminary results from a reader survey conducted September-October 2015 in collaboration with science communication researcher Dr. Paige Jarreau. The survey provides data on reader habits, motivations, attitudes, and demographics in order to assess how STARtorialist has influenced our readers' views on science, scientists, and the scientific community as a whole.

  4. Social  reading - the reader on digital margins

    Ivona Despot


    Full Text Available Electronic books enrich the reading experience through a range of possibilities digital technology offers, such as commenting or adding content at the margin space, marking interesting chapters and sharing the content with other readers. The phenomenon of social reading emerges with the influence of technology in the sphere of reading books and creates interactions for readers with the content and other readers. The great potential of enriching the reading experience is visible in the digital platforms for social reading, where the interaction and the creation of new content encourages the development of new way of reading and creativity. These activities may contribute to better understanding of the text. This enhances the communication about the text thus revitalizing the content and moves the reading itself from private to public sphere. This paper will show how are the activities in the digital margins transformed into a good indicator of the reading behavior, as well as the importance and usefulness of such for publishers to create new publishing products and services.

  5. Text Mining in Python through the HTRC Feature Reader

    Peter Organisciak


    Full Text Available We introduce a toolkit for working with the 13.6 million volume Extracted Features Dataset from the HathiTrust Research Center. You will learn how to peer at the words and trends of any book in the collection, while developing broadly useful Python data analysis skills. The HathiTrust holds nearly 15 million digitized volumes from libraries around the world. In addition to their individual value, these works in aggregate are extremely valuable for historians. Spanning many centuries and genres, they offer a way to learn about large-scale trends in history and culture, as well as evidence for changes in language or even the structure of the book. To simplify access to this collection the HathiTrust Research Center (HTRC has released the Extracted Features dataset (Capitanu et al. 2015: a dataset that provides quantitative information describing every page of every volume in the collection. In this lesson, we introduce the HTRC Feature Reader, a library for working with the HTRC Extracted Features dataset using the Python programming language. The HTRC Feature Reader is structured to support work using popular data science libraries, particularly Pandas. Pandas provides simple structures for holding data and powerful ways to interact with it. The HTRC Feature Reader uses these data structures, so learning how to use it will also cover general data analysis skills in Python.

  6. Testosterone for Poor Ovarian Responders

    Polyzos, Nikolaos P; Davis, Susan R; Drakopoulos, Panagiotis


    Testosterone, an androgen that directly binds to the androgen receptor, has been shown in previous small randomized controlled trials to increase the reproductive outcomes of poor ovarian responders. In most of these studies, transdermal testosterone in relatively high doses was administered before...... ovarian stimulation with a duration varying from 5 to 21 days. Nevertheless, the key question to be asked is whether, based on ovarian physiology and testosterone pharmacokinetics, a short course of testosterone administration of more than 10 mg could be expected to have any beneficial effect...... stages. In addition, extreme testosterone excess is not only likely to induce adverse events but has also the potential to be ineffective and even detrimental. Thus, evidence from clinical studies is not enough to either "reopen" or "close" the "androgen chapter" in poor responders, mainly because...

  7. An Investigation of the Effects of Reader Characteristics on Reading Comprehension Of a General Chemistry Text

    Neiles, Kelly Y.

    There is great concern in the scientific community that students in the United States, when compared with other countries, are falling behind in their scientific achievement. Increasing students' reading comprehension of scientific text may be one of the components involved in students' science achievement. To investigate students' reading comprehension this quantitative study examined the effects of different reader characteristics, namely, students' logical reasoning ability, factual chemistry knowledge, working memory capacity, and schema of the chemistry concepts, on reading comprehension of a chemistry text. Students' reading comprehension was measured through their ability to encode the text, access the meanings of words (lexical access), make bridging and elaborative inferences, and integrate the text with their existing schemas to make a lasting mental representation of the text (situational model). Students completed a series of tasks that measured the reader characteristic and reading comprehension variables. Some of the variables were measured using new technologies and software to investigate different cognitive processes. These technologies and software included eye tracking to investigate students' lexical accessing and a Pathfinder program to investigate students' schema of the chemistry concepts. The results from this study were analyzed using canonical correlation and regression analysis. The canonical correlation analysis allows for the ten variables described previously to be included in one multivariate analysis. Results indicate that the relationship between the reader characteristic variables and the reading comprehension variables is significant. The resulting canonical function accounts for a greater amount of variance in students' responses then any individual variable. Regression analysis was used to further investigate which reader characteristic variables accounted for the differences in students' responses for each reading comprehension

  8. Computational Sensing Using Low-Cost and Mobile Plasmonic Readers Designed by Machine Learning

    Ballard, Zachary S.


    Plasmonic sensors have been used for a wide range of biological and chemical sensing applications. Emerging nanofabrication techniques have enabled these sensors to be cost-effectively mass manufactured onto various types of substrates. To accompany these advances, major improvements in sensor read-out devices must also be achieved to fully realize the broad impact of plasmonic nanosensors. Here, we propose a machine learning framework which can be used to design low-cost and mobile multispectral plasmonic readers that do not use traditionally employed bulky and expensive stabilized light sources or high-resolution spectrometers. By training a feature selection model over a large set of fabricated plasmonic nanosensors, we select the optimal set of illumination light-emitting diodes needed to create a minimum-error refractive index prediction model, which statistically takes into account the varied spectral responses and fabrication-induced variability of a given sensor design. This computational sensing approach was experimentally validated using a modular mobile plasmonic reader. We tested different plasmonic sensors with hexagonal and square periodicity nanohole arrays and revealed that the optimal illumination bands differ from those that are “intuitively” selected based on the spectral features of the sensor, e.g., transmission peaks or valleys. This framework provides a universal tool for the plasmonics community to design low-cost and mobile multispectral readers, helping the translation of nanosensing technologies to various emerging applications such as wearable sensing, personalized medicine, and point-of-care diagnostics. Beyond plasmonics, other types of sensors that operate based on spectral changes can broadly benefit from this approach, including e.g., aptamer-enabled nanoparticle assays and graphene-based sensors, among others.

  9. Smartphone, tablet computer and e-reader use by people with vision impairment.

    Crossland, Michael D; Silva, Rui S; Macedo, Antonio F


    Consumer electronic devices such as smartphones, tablet computers, and e-book readers have become far more widely used in recent years. Many of these devices contain accessibility features such as large print and speech. Anecdotal experience suggests people with vision impairment frequently make use of these systems. Here we survey people with self-identified vision impairment to determine their use of this equipment. An internet-based survey was advertised to people with vision impairment by word of mouth, social media, and online. Respondents were asked demographic information, what devices they owned, what they used these devices for, and what accessibility features they used. One hundred and thirty-two complete responses were received. Twenty-six percent of the sample reported that they had no vision and the remainder reported they had low vision. One hundred and seven people (81%) reported using a smartphone. Those with no vision were as likely to use a smartphone or tablet as those with low vision. Speech was found useful by 59% of smartphone users. Fifty-one percent of smartphone owners used the camera and screen as a magnifier. Forty-eight percent of the sample used a tablet computer, and 17% used an e-book reader. The most frequently cited reason for not using these devices included cost and lack of interest. Smartphones, tablet computers, and e-book readers can be used by people with vision impairment. Speech is used by people with low vision as well as those with no vision. Many of our (self-selected) group used their smartphone camera and screen as a magnifier, and others used the camera flash as a spotlight. © 2014 The Authors Ophthalmic & Physiological Optics © 2014 The College of Optometrists.

  10. Does one report design suit all sorts of readers in the forest sector?

    Hartebrodt, C.


    Full Text Available Description of the subject. In the past two decades, new types of reports, such as sustainability reports, have become more important. Normally, issuing reports is a cost-intensive activity; however, the effectivity in terms of communicational success is often unknown. Research about forest reporting has often focused on general acceptance of different reporting concepts. Analysis about the perception of published reports is either uncommon or results may not be published for several internal reasons. Objectives. This double case study aims to identify if conceptual elements of sustainability reporting (SR meet the expectations of different target groups of public forest enterprises in two German provinces. Method. A three sphere model derived from communication theory is introduced and used to analyze the success of reports in different stakeholder groups. A set of hypotheses is derived from the state of knowledge on sustainability as well as corporate social responsibility reporting and is structured according to the model. The hypotheses are tested on the basis of a double case study. Results. It can be shown that satisfaction with traditional reports is already high; however, structural components of SR are also accepted. Readers want shorter reports and printed versions. Results indicate that the SR concept can be transferred to the readers of forest reports. Differences between stakeholder groups are mainly related to contents and different means of verification. Conclusions. The concept of SR can be basically applied in forest enterprises and meets the expectations of most readers. However, it must be kept in mind that traditional reporting concepts already meet most of the expectations of the relevant target groups. Any effort to implement a new reporting instrument should be supported by an ex ante evaluation of the expectations of the target readership.

  11. Energy poor or fuel poor: What are the differences?

    Li, Kang; Lloyd, Bob; Liang, Xiao-Jie; Wei, Yi-Ming


    Energy poverty and fuel poverty are descriptors of problems of households' energy consumption, they are both distinct problems and have been addressed by many researchers, organizations and governments. Cross use of the terms of energy poverty and fuel poverty in published papers is common. As an accurate descriptor is the presupposition of research and policy development, especially for those who just started to pay attention to this issue, this paper compares the definitions, research priorities, status quo, and problems of these two concepts, and summarizes the relationship between them. The paper suggests that only when the research targets are households who are living in a cold climate and have difficulty in getting access to electricity or modern cooking facilities, and in supplying indoor heating with appropriate cost, the concepts of energy poverty and fuel poverty have the chance to be broadened and mutually integrated. - Highlights: • Address energy poverty and fuel poverty simultaneously. • Compare energy poverty and fuel poverty from 4 perspectives. • Summarize the relationship between energy poverty and fuel poverty. • Divide energy poor and fuel poor into three categories

  12. Predicting Text Comprehension, Processing, and Familiarity in Adult Readers: New Approaches to Readability Formulas

    Crossley, Scott A.; Skalicky, Stephen; Dascalu, Mihai; McNamara, Danielle S.; Kyle, Kristopher


    Research has identified a number of linguistic features that influence the reading comprehension of young readers; yet, less is known about whether and how these findings extend to adult readers. This study examines text comprehension, processing, and familiarity judgment provided by adult readers using a number of different approaches (i.e.,…

  13. A General Audiovisual Temporal Processing Deficit in Adult Readers with Dyslexia

    Francisco, Ana A.; Jesse, Alexandra; Groen, Margriet A.; McQueen, James M.


    Purpose: Because reading is an audiovisual process, reading impairment may reflect an audiovisual processing deficit. The aim of the present study was to test the existence and scope of such a deficit in adult readers with dyslexia. Method: We tested 39 typical readers and 51 adult readers with dyslexia on their sensitivity to the simultaneity of…

  14. A general audiovisual temporal processing deficit in adult readers with dyslexia

    Francisco, A.A.; Jesse, A.; Groen, M.A.; McQueen, J.M.


    Purpose: Because reading is an audiovisual process, reading impairment may reflect an audiovisual processing deficit. The aim of the present study was to test the existence and scope of such a deficit in adult readers with dyslexia. Method: We tested 39 typical readers and 51 adult readers with

  15. Bimodal Reading: Benefits of a Talking Computer for Average and Less Skilled Readers.

    Montali, Julie; Lewandowski, Lawrence


    Eighteen average readers and 18 less-skilled readers (grades 8 and 9) were presented with social studies and science passages via a computer either visually (on screen), auditorily (read by digitized voice), or bimodally (on screen, highlighted while being voiced). Less-skilled readers demonstrated comprehension in the bimodal condition equivalent…

  16. Computer Games versus Maps before Reading Stories: Priming Readers' Spatial Situation Models

    Smith, Glenn Gordon; Majchrzak, Dan; Hayes, Shelley; Drobisz, Jack


    The current study investigated how computer games and maps compare as preparation for readers to comprehend and retain spatial relations in text narratives. Readers create situation models of five dimensions: spatial, temporal, causal, goal, and protagonist (Zwaan, Langston, & Graesser 1995). Of these five, readers mentally model the spatial…

  17. French Immersion Experience and Reading Skill Development in At-Risk Readers

    Kruk, Richard S.; Reynolds, Kristin A. A.


    We tracked the developmental influences of exposure to French on developing English phonological awareness, decoding and reading comprehension of English-speaking at-risk readers from Grade 1 to Grade 3. Teacher-nominated at-risk readers were matched with not-at-risk readers in French immersion and English language programs. Exposure to spoken…

  18. Follow the Reader: An Effective Strategy to Support Students Reading More Complex Text

    Klvacek, Michelle L.; Monroe, Eula Ewing; Wilcox, Brad; Hall-Kenyon, Kendra M.; Morrison, Timothy G.


    This article describes how one second-grade teacher implemented Follow the Reader, her term for dyad reading. Common Core expects students to read increasingly complex texts. Teachers can implement dyad reading with this end in mind. It is a modified version of the neurological impress method in which a lead reader and an assisted reader sit side…

  19. Poorly studied phenomena in geoelectrics

    В. С. Могилатов


    Full Text Available Undoubtedly, modern geoelectric technologies emerge in the result of the development of traditional approaches and techniques. However of more interest is the appearance of completely new technologies based on new effects and new models of interaction of geological medium and electromagnetic field. The author does not commit to indicate principally new directions, but only wants to discuss some poorly known facts from the theory and practice of geoelectrics. The outcome of this study could be considered attracting the attention of experts to non-traditional signals in geoelectrics. The reviewed phenomena of interest, not fully implemented in practice in the author’s opinion, are field split into two polarizations: transverse electric (the ТЕ-field and transverse magnetic (the ТМ-field, then some poorly known properties of ТМ-field, the role of bias currents, the anisotropy of horizontal resistances, the role of geomagnetic field in geoelectric sounding, the unique resolution of CSEM (Controlled Source Electro-Magnetic techniques at sea.

  20. Poor mental health status and aggression are associated with poor driving behavior among male traffic offenders

    Abdoli N


    Full Text Available Nasrin Abdoli,1,2 Vahid Farnia,3 Ali Delavar,4 Alirez Esmaeili,5 Fariborz Dortaj,4 Noorali Farrokhi,4 Majid Karami,6 Jalal Shakeri,3 Edith Holsboer-Trachsler,7 Serge Brand7,8 1International University of Imam Reza, Mashhad, 2Kermanshah University of Medical Sciences, Kermanshah, 3Substance Abuse Prevention Research Center, Psychiatry Department, Kermanshah University of Medical Sciences, Kermanshah, 4Allameh Tabataba’i University, Tehran, 5Police University, Tehran, 6Baharestan Research Center, Kermanshah Transportation Terminal, Kermanshah, Iran, 7Center for Affective, Stress and Sleep Disorders, Psychiatric Clinics of the University of Basel, Basel, 8Department of Sport and Health Science, Sport Science Section, University of Basel, Basel, Switzerland Background: In Iran, traffic accidents and deaths from traffic accidents are among the highest in the world, and generally driver behavior rather than either technical failures or environmental conditions are responsible for traffic accidents. In the present study, we explored the extent to which aggressive traits, health status, and sociodemographic variables explain driving behavior among Iranian male traffic offenders. Method: A total of 443 male driving offenders (mean age: M =31.40 years, standard deviation =9.56 from Kermanshah (Iran took part in the study. Participants completed a questionnaire booklet covering sociodemographic variables, traits of aggression, health status, and driving behavior. Results: Poor health status, such as symptoms of depression, anxiety, insomnia, and social dysfunction, and also higher levels of trait aggression explained poor driving behavior. Multiple regressions indicated that poor health status, but not aggression, independently predicted poor driving behavior. Conclusion: Results suggest that health status concerns are associated with poor driving behavior. Prevention and intervention might therefore focus on drivers reporting poor mental health status

  1. Thyroid disorders in patients with newly diagnosed rheumatoid arthritis is associated with poor initial treatment response evaluated by disease activity score in 28 joints-C-reactive protein (DAS28-CRP)

    Emamifar, Amir; Hangaard, Jørgen; Jensen Hansen, Inger Marie


    peptide antibody (anti-CCP), and antinuclear antibody (ANA), and also disease activity score in 28 joints-C-reactive protein at the time of diagnosis and after 4 months (±1–2 months) of treatment initiation were extracted from Danish Danbio Registry. Patients’ electronic hospital records for the past 10...... years were reviewed to reveal if they had been diagnosed with thyroid disorders or they had abnormal thyroid test.In all, 439 patients were included, female 60.1%, mean age 64.6 ± 15.0 years and disease duration 2.6 ± 1.7 years. Prevalence of thyroid disorders was 69/439 (15.7%) and hypothyroidism...... treatment compared with patients with isolated RA after 4 months of treatment (P = .02). There were no associations between thyroid disorders and age, disease duration, and also IgM RF positivity.Presence of thyroid disorders in RA patients is suggestive of a more aggressive disease and poor outcome...

  2. Instant responsive web design

    Simmons, Cory


    A step-by-step tutorial approach which will teach the readers what responsive web design is and how it is used in designing a responsive web page.If you are a web-designer looking to expand your skill set by learning the quickly growing industry standard of responsive web design, this book is ideal for you. Knowledge of CSS is assumed.

  3. Integrated Rapid-Diagnostic-Test Reader Platform on a Cellphone

    Mudanyali, Onur; Dimitrov, Stoyan; Sikora, Uzair; Padmanabhan, Swati; Navruz, Isa; Ozcan, Aydogan


    We demonstrate a cellphone based Rapid-Diagnostic-Test (RDT) reader platform that can work with various lateral flow immuno-chromatographic assays and similar tests to sense the presence of a target analyte in a sample. This compact and cost-effective digital RDT reader, weighing only ~65 grams, mechanically attaches to the existing camera unit of a cellphone, where various types of RDTs can be inserted to be imaged in reflection or transmission modes under light-emitting-diode (LED) based illumination. Captured raw images of these tests are then digitally processed (within less than 0.2 sec/image) through a smart application running on the cellphone for validation of the RDT as well as for automated reading of its diagnostic result. The same smart application running on the cellphone then transmits the resulting data, together with the RDT images and other related information (e.g., demographic data) to a central server, which presents the diagnostic results on a world-map through geo-tagging. This dynamic spatio-temporal map of various RDT results can then be viewed and shared using internet browsers or through the same cellphone application. We tested this platform using malaria, tuberculosis (TB) as well as HIV RDTs by installing it on both Android based smart-phones as well as an iPhone. Providing real-time spatio-temporal statistics for the prevalence of various infectious diseases, this smart RDT reader platform running on cellphones might assist health-care professionals and policy makers to track emerging epidemics worldwide and help epidemic preparedness. PMID:22596243

  4. Survey of reader preferences concerning the format of NASA technical reports

    Pinelli, T. E.; Glassman, M.; Cordle, V. M.


    A survey was conducted to determine the opinions of readers concerning the format (organization) of NASA technical reports and usage of technical report components. A survey questionnaire was sent to 513 LaRC engineers and scientists and 600 engineers and scientists from three (3) professional/technical societies. The response rates were 74 and 85 percent, respectively. The questionnaire included the order in which users read report components, the components reviewed or read to determine whether to read a report, report components which could be deleted, the desirability of a table of contents, the desirability of both a summary and abstract, the location of the symbols list and glossary, the integration of illustrative material, the preferred format for reference citations, column layout and right margin treatment, and person/voice. The results of the reader preference survey indicated that the conclusion was the component most often ready by survey respondents. The summary, conclusion, abstract, title page, and introduction were the components used most frequently to determine if a report would actually be read. Respondents indicated that a summary as well as an abstract should be included, that the definition of symbols and glossary of terms should be located in the front of the report, and that illustrative material should be integrated with the text rather than grouped at the end of the report. Citation by number was the preferred format for references. A one-column, ragged right margin was preferred. Third person, passive voice was the style of writing preferred by the respondents.

  5. Assessing reader performance in radiology, an imperfect science: Lessons from breast screening

    Soh, B.P., E-mail: [Medical Image Optimisation and Perception Group (MIOPeG), Faculty of Health Sciences, University of Sydney, Lidcombe, NSW (Australia); Lee, W.; Kench, P.L.; Reed, W.M.; McEntee, M.F.; Poulos, A.; Brennan, P.C. [Medical Image Optimisation and Perception Group (MIOPeG), Faculty of Health Sciences, University of Sydney, Lidcombe, NSW (Australia)


    The purpose of this article is to review the limitations associated with current methods of assessing reader accuracy in mammography screening programmes. Clinical audit is commonly used as a quality-assurance tool to monitor the performance of screen readers; however, a number of the metrics employed, such as recall rate as a surrogate for specificity, do not always accurately measure the intended clinical feature. Alternatively, standardized screening test sets, which benefit from ease of application, immediacy of results, and quicker assessment of quality improvement plans, suffer from experimental confounders, thus questioning the relevance of these laboratory-type screening test sets to clinical performance. Four key factors that impact on the external validity of screening test sets were identified: the nature and extent of scrutiny of one's action, the artificiality of the environment, the over-simplification of responses, and prevalence of abnormality. The impact of these factors on radiological and other contexts is discussed, and although it is important to acknowledge the benefit of standardized screening test sets, issues relating to the relevance of test sets to clinical activities remain. The degree of correlation between performance based on real-life clinical audit and performances at screen read test sets must be better understood and specific causal agents for any lack of correlation identified.

  6. Playing [with] multiple roles: Readers, authors, and characters in "Who Is Blaise Zabini?" [symposium

    Anne Collins Smith


    Full Text Available Fans who produce fan works in genres such as fiction, music, and music video take on dual roles in the process, as readers of the original canon and as creators of their own products. These roles—and more—are creatively explored in the Parselmouths' wizard rock composition "Who Is Blaise Zabini?". Like many works of fan fiction, the Parselmouths' songs move beyond a reader's ordinary role, taking on an authorial role to generate new characters and events in the Harry Potter universe. What makes this particular work unusual is that at the same time that they are adopting the roles of authors, and even of participants, the Parselmouths also restrict their own authorial and participatory power, claiming that the Slytherin characters they portray could not perceive their classmate Blaise Zabini until J. K. Rowling provided a complete description of him. To untangle their multiple roles and to recognize the creativity exercised by the Parselmouths in collapsing the boundaries among them, it will be helpful to turn to a theory of audience response that delineates specific roles and that specifies the limitations and the powers inherent in them.

  7. The Animals Reader: The Essential Classic and Contemporary Writings (Linda Kalof y Amy Fitzgerald, Eds.

    Beto Vianna


    Full Text Available Las propuestas explicativas de la sociobiología y, aún más recientemente, de la psicología evolucionista han suscitado la queja, entre los científicos humanos, de una “colonización de las ciencias sociales” (término de Rose, 2000 desde la biología. La queja es legítima, si no por otros motivos, por una lamentable tendencia a la simplificación de las intricadas redes conductuales humanas a través de “explicaciones evolutivas”. Pero no podemos olvidar que hay un movimiento de igual tamaño e impacto desde las ciencias sociales que, a ejemplo de Bruno Latour, Tim Ingold y tantos otros, “colonizan” los estudios y objetos naturales (ver, por ejemplo, Latour, 1996 e Ingold, 2008. En The Animals Reader, dos sociólogas - Linda Kalof, de la Universidad del Estado de Michigan, y Amy Fitzgerald, de la Universidade de Windsor, Canada - son las responsables de hacer una incursión en un territorio tradicionalmente natural y, por tanto, perteneciente a las ciencias de la naturaleza: las descripciones que hacemos y las relaciones que mantenemos con los animales. The Animals Reader es una compilación bien cuidada, pienso que la primera de su tipo, que da forma a una preocupación multidisciplinar: los “estudios animales”.

  8. Optimized Lateral Flow Immunoassay Reader for the Detection of Infectious Diseases in Developing Countries.

    Pilavaki, Evdokia; Demosthenous, Andreas


    Detection and control of infectious diseases is a major problem, especially in developing countries. Lateral flow immunoassays can be used with great success for the detection of infectious diseases. However, for the quantification of their results an electronic reader is required. This paper presents an optimized handheld electronic reader for developing countries. It features a potentially low-cost, low-power, battery-operated device with no added optical accessories. The operation of this proof of concept device is based on measuring the reflected light from the lateral flow immunoassay and translating it into the concentration of the specific analyte of interest. Characterization of the surface of the lateral flow immunoassay has been performed in order to accurately model its response to the incident light. Ray trace simulations have been performed to optimize the system and achieve maximum sensitivity by placing all the components in optimum positions. A microcontroller enables all the signal processing to be performed on the device and a Bluetooth module allows transmission of the results wirelessly to a mobile phone app. Its performance has been validated using lateral flow immunoassays with influenza A nucleoprotein in the concentration range of 0.5 ng/mL to 200 ng/mL.

  9. Optimized Lateral Flow Immunoassay Reader for the Detection of Infectious Diseases in Developing Countries

    Evdokia Pilavaki


    Full Text Available Detection and control of infectious diseases is a major problem, especially in developing countries. Lateral flow immunoassays can be used with great success for the detection of infectious diseases. However, for the quantification of their results an electronic reader is required. This paper presents an optimized handheld electronic reader for developing countries. It features a potentially low-cost, low-power, battery-operated device with no added optical accessories. The operation of this proof of concept device is based on measuring the reflected light from the lateral flow immunoassay and translating it into the concentration of the specific analyte of interest. Characterization of the surface of the lateral flow immunoassay has been performed in order to accurately model its response to the incident light. Ray trace simulations have been performed to optimize the system and achieve maximum sensitivity by placing all the components in optimum positions. A microcontroller enables all the signal processing to be performed on the device and a Bluetooth module allows transmission of the results wirelessly to a mobile phone app. Its performance has been validated using lateral flow immunoassays with influenza A nucleoprotein in the concentration range of 0.5 ng/mL to 200 ng/mL.

  10. Assessing user preferences for e-readers and tablets.

    Le Ber, Jeanne M; Lombardo, Nancy T; Honisett, Amy; Jones, Peter Stevens; Weber, Alice


    Librarians purchased 12 e-readers and six tablets to provide patrons the opportunity to experiment with the latest mobile technologies. After several train-the-trainer sessions, librarians shared device information with the broader health sciences community. Devices were cataloged and made available for a two-week checkout. A limited number of books and applications (apps) were preloaded for all the devices, and patrons were allowed to download their own content. Each tablet has Google Books, iBooks, Kindle, and Nook apps available to allow choice in reading e-books. Upon return, patrons were asked to complete a ten-question survey to determine preferences for device use.

  11. Reader-taylor: sewing and plotting the “text”

    Luciane Bernardi Souza


    Full Text Available This article discusses the presence of the ‘empty slots in the text’ in the short story "Imagens desabrigadas" of the writer Luci Collin. Investigates, therefore, the importance of these ‘openings to the textual’ embodiment of literary writing and also contributes to the emancipation of the reader in his encounter with the text. To this end, we raised some theoretic support brought by Wolfgang Iser and Terry Eagleton, as well as the reception theory of the literary text.

  12. First French reader a beginner's dual-language book

    Appelbaum, Stanley


    This excellent anthology offers the beginning French-language student a first taste of some of the world's most significant prose. Chosen for both their eloquence and ease of reading, excerpts from such masterpieces as Les Misérables, The Red and the Black, Madame Bovary, Carmen, and The Three Musketeers will open new worlds for linguists. Readers will savor the words of fifty great writers of multiple genres from the seventeenth through twentieth centuries, including Voltaire, Rousseau, Balzac, Baudelaire, Dumas, Proust, and other literary virtuosos.Lucid and accessible, the unabridged Englis

  13. Serving the world's poor, profitably.

    Prahalad, C K; Hammond, Allen


    By stimulating commerce and development at the bottom of the economic pyramid, multi-nationals could radically improve the lives of billions of people and help create a more stable, less dangerous world. Achieving this goal does not require MNCs to spearhead global social-development initiatives for charitable purposes. They need only act in their own self-interest. How? The authors lay out the business case for entering the world's poorest markets. Fully 65% of the world's population earns less than $2,000 per year--that's 4 billion people. But despite the vastness of this market, it remains largely untapped. The reluctance to invest is easy to understand, but it is, by and large, based on outdated assumptions of the developing world. While individual incomes may be low, the aggregate buying power of poor communities is actually quite large, representing a substantial market in many countries for what some might consider luxury goods like satellite television and phone services. Prices, and margins, are often much higher in poor neighborhoods than in their middle-class counterparts. And new technologies are already steadily reducing the effects of corruption, illiteracy, inadequate infrastructure, and other such barriers. Because these markets are in the earliest stages of economic development, revenue growth for multi-nationals entering them can be extremely rapid. MNCs can also lower costs, not only through low-cost labor but by transferring operating efficiencies and innovations developed to serve their existing operations. Certainly, succeeding in such markets requires MNCs to think creatively. The biggest change, though, has to come from executives: Unless business leaders confront their own preconceptions--particularly about the value of high-volume, low-margin businesses--companies are unlikely to master the challenges or reap the rewards of these developing markets.

  14. Some dosimetric properties of the LiF:Mg,Ti evaluated by the automatic 6600 thermoluminescent reader

    Ben-Shachar, B; Weinstein, M; German, U [Israel Atomic Energy Commission, Beersheba (Israel). Nuclear Research Center-Negev


    Some dosimetric properties of the new LiF:Mg,Ti TLD cards were checked, when evaluated by the new automatic 6600 TLD reader. The cards were calibrated to a dose of 1.0 mGy by five identical irradiations, and the TL-dose response was measured for a range of 75 - 1100 mGy. A very high accuracy was found for the three kind of chips measured (TLD-100, TLD-700 and TLD-600) and a low minimum measurable dose (MMD) was found, too. There is a good fit between the analytical evaluation and the theoretical calculation of the MMD. The results obtained are much better than those of the LiF:Mg,Ti cards evaluated by the older automatic 2271 reader used in the last two decades (authors).

  15. Accelerated Reader[R]: What Are the Lasting Effects on the Reading Habits of Middle School Students Exposed to Accelerated Reader[R] in Elementary Grades?

    Pavonetti, Linda M.; Brimmer, Kathryn M.; Cipielewski, James F.

    Promoted by effective advertising and disseminated by word of mouth, many schools have adopted Accelerated Reader[R] as a supplementary reading program or as their primary reading program. Accelerated Reader[R]'s philosophy is that by using the system, students are motivated to read more and better books. A study investigated whether seventh grade…

  16. A Minkowski Fractal Circularly Polarized Antenna for RFID Reader

    Yanzhong Yu


    Full Text Available A design of fractal-like antenna with circular polarization for radio frequency identification (RFID reader applications is presented in this article. The modified Minkowski fractal structure is adopted as radiating patch for size reduction and broadband operation. A corner-truncated technology and a slot-opened method are employed to realize circular polarization and improve the gain of the proposed antenna, respectively. The proposed antenna is analyzed and optimized by HFSS. Return loss and maximum gain of the optimized antenna achieve to -22.2 dB and 1.12 dB at 920 MHz, respectively. The optimized design has an axial ratio (AR of 1.2 dB at central frequency of 920 MHz and impedance bandwidth (S11<=-10 dB of 40 MHz (4.3 %. Its input impedance is (57.9-j2.6 W that is close to input impedance of coaxial line (50 W. Numerical results demonstrate that the optimized antenna exhibits acceptable performances and may satisfy requirements of RFID reader applications.

  17. Signal and array processing techniques for RFID readers

    Wang, Jing; Amin, Moeness; Zhang, Yimin


    Radio Frequency Identification (RFID) has recently attracted much attention in both the technical and business communities. It has found wide applications in, for example, toll collection, supply-chain management, access control, localization tracking, real-time monitoring, and object identification. Situations may arise where the movement directions of the tagged RFID items through a portal is of interest and must be determined. Doppler estimation may prove complicated or impractical to perform by RFID readers. Several alternative approaches, including the use of an array of sensors with arbitrary geometry, can be applied. In this paper, we consider direction-of-arrival (DOA) estimation techniques for application to near-field narrowband RFID problems. Particularly, we examine the use of a pair of RFID antennas to track moving RFID tagged items through a portal. With two antennas, the near-field DOA estimation problem can be simplified to a far-field problem, yielding a simple way for identifying the direction of the tag movement, where only one parameter, the angle, needs to be considered. In this case, tracking of the moving direction of the tag simply amounts to computing the spatial cross-correlation between the data samples received at the two antennas. It is pointed out that the radiation patterns of the reader and tag antennas, particularly their phase characteristics, have a significant effect on the performance of DOA estimation. Indoor experiments are conducted in the Radar Imaging and RFID Labs at Villanova University for validating the proposed technique for target movement direction estimations.

  18. From Reader to Writer: Citizen Journalism as News Produsage

    Bruns, Axel

    Today, participatory or citizen journalism - journalism which enables readers to become writers - exists online and offline in a variety of forms and formats, operates under a number of editorial schemes, and focuses on a wide range of topics from the specialist to the generic and the micro-local to the global. Key models in this phenomenon include veteran sites Slashdot and Indymedia, as well as news-related weblogs; more recent additions into the mix have been the South Korean OhmyNews, which in 2003 was “the most influential online news site in that country, attracting an estimated 2 million readers a day” (Gillmor, 2003a, p. 7), with its new Japanese and international offshoots, as well as the Wikipedia with its highly up-to-date news and current events section and its more recent offshoot Wikinews, and even citizen-produced video news as it is found in sites such as YouTube and

  19. Using miscue analysis to assess comprehension in deaf college readers.

    Albertini, John; Mayer, Connie


    For over 30 years, teachers have used miscue analysis as a tool to assess and evaluate the reading abilities of hearing students in elementary and middle schools and to design effective literacy programs. More recently, teachers of deaf and hard-of-hearing students have also reported its usefulness for diagnosing word- and phrase-level reading difficulties and for planning instruction. To our knowledge, miscue analysis has not been used with older, college-age deaf students who might also be having difficulty decoding and understanding text at the word level. The goal of this study was to determine whether such an analysis would be helpful in identifying the source of college students' reading comprehension difficulties. After analyzing the miscues of 10 college-age readers and the results of other comprehension-related tasks, we concluded that comprehension of basic grade school-level passages depended on the ability to recognize and comprehend key words and phrases in these texts. We also concluded that these diagnostic procedures provided useful information about the reading abilities and strategies of each reader that had implications for designing more effective interventions.

  20. Resposta broncodilatadora imediata ao formoterol em doença pulmonar obstrutiva crônica com pouca reversibilidade Immediate bronchodilator response to formoterol in poorly reversible chronic obstructive pulmonary disease

    Adalberto Sperb Rubin


    Full Text Available OBJETIVO: Avaliar, por meio de provas de função pulmonar, a eficácia broncodilatadora do formoterol após 30 min de sua administração em portadores de doença pulmonar obstrutiva crônica (DPOC com pouca reversibilidade. MÉTODOS: Estudo prospectivo incluindo 40 pacientes portadores de DPOC com resposta negativa ao broncodilatador de curta duração utilizado no teste espirométrico-variação menor que 200 mL e 7% do previsto do volume expiratório forçado no primeiro segundo (VEF1. Os pacientes encontravam-se nos estágios II, III ou IV da DPOC (Sociedade Brasileira de Pneumologia e Tisiologia/Global Initiative for Chronic Obstructive Lung Disease e apresentavam VEF1 OBJECTIVE: To evaluate, using pulmonary function tests, the effectiveness of formoterol as a bronchodilator at 30 min after its administration in patients with poorly reversible COPD. METHODS: A prospective study including 40 COPD patients not responding to the short-acting bronchodilator used in the spirometric test-variation of less than 200 mL and less than 7% of predicted in forced expiratory volume in one second (FEV1. All patients were classified as having stage II, III, or IV COPD (Brazilian Thoracic Society/Global Initiative for Chronic Obstructive Lung Disease and presented FEV1 < 70% of predicted value. The patients were randomized into two groups of 20, with similar clinical characteristics, receiving, via a dry powder inhaler, either formoterol or a placebo. The pulmonary function testing (plethysmography was repeated at 30 min after formoterol or placebo administration. RESULTS: In the formoterol group, the mean values obtained for FEV1, inspiratory capacity, and forced vital capacity were significantly greater than those obtained in the placebo group (p = 0.00065, p = 0.05, and p = 0.017, respectively, whereas that obtained for airway resistance was significantly lower (p = 0.010. Less pronounced differences were observed for residual volume, vital capacity and

  1. Multilevel Analysis of Multiple-Baseline Data Evaluating Precision Teaching as an Intervention for Improving Fluency in Foundational Reading Skills for at Risk Readers

    Brosnan, Julie; Moeyaert, Mariola; Brooks Newsome, Kendra; Healy, Olive; Heyvaert, Mieke; Onghena, Patrick; Van den Noortgate, Wim


    In this article, multiple-baseline across participants designs were used to evaluate the impact of a precision teaching (PT) program, within a Tier 2 Response to Intervention framework, targeting fluency in foundational reading skills with at risk kindergarten readers. Thirteen multiple-baseline design experiments that included participation from…

  2. Mandated empowerment: handing antipoverty policy back to the poor?

    Banerjee, Abhijit V; Duflo, Esther


    The current trend in antipoverty policy emphasizes mandated empowerment: the poor are being handed the responsibility for making things better for themselves, largely without being asked whether this is what they want. Beneficiary control is now being built into public service delivery, while microcredit and small business promotion are seen as better ways to help the poor. The clear presumption is that the poor are both able and happy to exercise these new powers. This essay uses two examples to raise questions about these strategies. The first example is about entrepreneurship among the poor. Using data from a number of countries, we argue that there is no evidence that the median poor entrepreneur is trying his best to expand his existing businesses, even if we take into account the many constraints he faces. While many poor people own businesses, this seems to be more a survival strategy than something they want to do. The second example comes from an evaluation of a program in India that aims to involve poor rural parents in improving local public schools. The data suggest that despite being informed that they now have both the right to intervene in the school and access to funds for that purpose, and despite being made aware of how little the children were learning, parents opt to not get involved. Both examples raise concerns about committing ourselves entirely to antipoverty strategies that rely on the poor doing a lot of the work.

  3. Response

    Higgins, Chris


    This article presents the author's response to the reviews of his book, "The Good Life of Teaching: An Ethics of Professional Practice." He begins by highlighting some of the main concerns of his book. He then offers a brief response, doing his best to address the main criticisms of his argument and noting where the four reviewers (Charlene…

  4. Crohn's Disease Evaluated with Magnetic Resonance Enteroclysis: Diagnostic Performance of Experienced and Inexperienced Readers before and after Training

    Negaard, A.; Mulahasanovic, A.; Reisaeter, L.A.; Aasekjaer, K.; Sandvik, L.; Klow, N.E.


    Background: Magnetic resonance enteroclysis (MRE) is suggested to become the preferred radiological method in small-bowel Crohn's disease (CD). However, the performance of inexperienced readers may influence the diagnostic value of the method and has not been previously investigated. Purpose: To compare readings of MRE in small-bowel CD performed by experienced and inexperienced readers before and after training.Material and Methods: One experienced radiologist (observer 1) and two trainees (observers 2 and 3) reviewed 60 MRE examinations. A second reading was performed after training. Bowel wall thickness (BWT), ulcers (BWU), stenosis (BWS), fistulas (FIS), and abscesses (ABS) were evaluated. A reference standard based on clinical records was established. Results: BWT in the terminal ileum was evaluated with high diagnostic performance (sensitivity: observer 1, 83%; observer 2, 72%; observer 3, 78%). Only BWU was diagnosed with a higher sensitivity by observer 1 (78% vs. 33% and 39%, respectively; P=0.02). False-positive findings for BWT in the jejunum (observer 2: 7; observer 3: 4) and fistulas and abscesses (observer 2: 11/5; observer 3: 5/4) were made by the trainees. Interobserver agreement in the jejunum was poor (observer 1/observer 2: κ=0.23; observer 1/observer 3: κ=-0.03) and in the ileum good (observer 1/observer 2: κ=0.78; observer 1/observer 3: κ=0.73). After training, evaluation of BWU (observer 2: 56%, P=0.22; observer 3: 44%, P=0.03), BWT (observer 2: 2; observer 3: 2), and interobserver agreement in the jejunum improved (observer 1/observer 2: κ=0.66; observer 1/observer 3: κ=0.66). However, the number of diagnosed fistulas and abscesses remained high. Conclusion: Before training, most findings of Crohn's disease in the terminal ileum were evaluated with high diagnostic performance by all readers. However, the inexperienced readers evaluated BWU with a low sensitivity and overestimated the number of FIS, number of ABS, and increased BWT in

  5. Pro Poor Growth in Cameroon

    Samuel Fambon


    Full Text Available The purpose of this paper is to analyze the relationship between economic growth, poverty and income distribution in Cameroon, using both the data derived from three Cameroonian household surveys and the Poverty Equivalent Growth Rate (PEGR methodology developed by Kakwani et al. (2004, The study found that economic growth in Cameroon was pro poor over the period 1996–2007, which suggests that instead of increasing the economic growth rate alone, the poverty equivalent growth rate should also be maximized to achieve the poverty reduction objective, meaning that on the one hand, the growth rate should be boosted, and on the other, the distribution of income should also be concurrently improved. A decomposition of changes in poverty using the Kakwani (1997 approach reveal that the growth component dominates the redistribution component in the reduction of poverty. This suggests that the fall in absolute poverty over the survey period may be attributed to an increase in average household income, and not to the redistributive policies of the government.

  6. Effect of computer-aided detection as a second reader in multidetector-row CT colonography

    Mang, Thomas; Peloschek, Philipp; Plank, Christina; Maier, Andrea; Weber, Michael; Herold, Christian; Schima, Wolfgang; Graser, Anno; Bogoni, Luca


    Our purpose was to assess the effect of computer-aided detection (CAD) on lesion detection as a second reader in computed tomographic colonography, and to compare the influence of CAD on the performance of readers with different levels of expertise. Fifty-two CT colonography patient data-sets (37 patients: 55 endoscopically confirmed polyps ≥0.5 cm, seven cancers; 15 patients: no abnormalities) were retrospectively reviewed by four radiologists (two expert, two nonexpert). After primary data evaluation, a second reading augmented with findings of CAD (polyp-enhanced view, Siemens) was performed. Sensitivities and reading time were calculated for each reader without CAD and supported by CAD findings. The sensitivity of expert readers was 91% each, and of nonexpert readers, 76% and 75%, respectively, for polyp detection. CAD increased the sensitivity of expert readers to 96% (P = 0.25) and 93% (P = 1), and that of nonexpert readers to 91% (P = 0.008) and 95% (P = 0.001), respectively. All four readers diagnosed 100% of cancers, but CAD alone only 43%. CAD increased reading time by 2.1 min (mean). CAD as a second reader significantly improves sensitivity for polyp detection in a high disease prevalence population for nonexpert readers. CAD causes a modest increase in reading time. CAD is of limited value in the detection of cancer. (orig.)

  7. Verbal Reports of Proficient Readers In Coping With Unfamiliar Words

    Kusumarasdyati Kusumarasdyati


    Full Text Available The present study reports the actual strategy use of good readers when they face hindrance in the form of unfamiliar words. Eight undergraduates majoring in English at Surabaya State University performed think-aloud while reading two texts to find out how they coped with such difficulties. The verbal protocol indicated that half of the participants mainly relied on a bilingual (English-Indonesian dictionary to attack unfamiliar words, and only one of them preferred to use a monolingual (English-English one. Two of them employed context cues to infer the meaning of the words, while one participant combined the use of context cues and a monolingual dictionary as the major strategy. All but one of the participants skipped some of lexical items whose meaning was unknown to them, especially when these words did not have a key contribution to the meaning of the whole text.

  8. The African Novel and the Western Reader. A Case Study

    Julien Vermeulen


    Full Text Available African literature, like any other literature remote in space or time, can be approached in two different ways. We can read it from our own point of view and try to appreciate it with our own literary standards. We can also try to read it as it was experienced and appreciated by its immediate audience, which means by the African public at the time of publication. Reactions given by a group of Dutch-speaking readers on a novel by E. Dongala clearly illustrate that the second approach is hardly achievable, however attractive it may seem. So we have to accept that every reading of an African literary work implies a serious degree of creative treason. KEYWORDS : Literary reception, literary criticism, African literature in French, E. Dongala

  9. Research on Positioning Algorithm of Forklift-mounted RFID Reader

    Hongjin Wang


    Full Text Available To conduct real-time and accurate positioning of the forklifts (people and goods in the warehouse is an effective means for improving warehouse management efficiency. To this end, this article puts forward the active positioning system with the forklift installed with RFID reader and the ground passageway embedded with RFID tag. In the running process, the position of forklift can be determined through recognition of the reference tags which are embedded at both sides of the passageway based on the three-side layout at right angle principle and their RSSI value. The positional accuracy can be improved by adjusting the layout distance of those reference tags. The experimental results show that this system can realize the positioning function of forklift, and it can be used in practical situations.

  10. Astrobites: The Astro-ph Reader's Digest For Undergraduates

    Kohler, Susanna; Astrobites Team


    Astrobites ( is a daily blog aimed primarily at undergraduates interested in astrophysical research and written by a team of graduate students located at diverse institutions around the world. Nearly every day we present a journal article recently posted to astro-ph in a brief format that is accessible to anyone with a general background in the physical sciences. In addition to summarizing new work, Astrobites provides valuable context for readers not yet familiar with the astrophysical literature. Special posts offer career guidance for undergraduates (e.g. applying for an NSF graduate fellowship) and describe personal experiences (e.g. attending an astronomy summer school). We will discuss the Astrobites format and recent readership statistics, as well as potential methods for incorporating Astrobites into the classroom.

  11. Updates from Astrobites: The Astro-ph Reader's Digest

    Montet, Benjamin; Chisari, N.; Donaldson, J.; Dressing, C. D.; Drout, M.; Faesi, C.; Fuchs, J. T.; Kohler, S.; Lovegrove, E.; Mills, E. A.; Nesvold, E.; Newton, E. R.; Olmstead, A.; Vasel, J. A.; Weiss, L. M.; Astrobites Team


    Astrobites ( is a daily blog aimed at undergraduates interested in astrophysical research and written by a team of graduate students located at diverse institutions across the United States. Primarily, we present journal articles recently posted to astro-ph in a brief format that is accessible to anyone with a general background in the physical sciences, including readers who are not yet familiar with the astrophysical literature. Special posts offer career guidance for undergraduates (e.g. applying for an NSF graduate fellowship) and describe personal experiences (e.g. attending an astronomy summer school). We present recent readership statistics and potential methods for incorporating Astrobites into the classroom. We also discuss the Astrobites format across multiple social media platforms, including the newly launched Astroplots, and highlight our recent work organizing the annual "Communicating Science" workshop for graduate students.


    Fatih Bayram


    Giving information is one of the main function of mass communication tools. Newspaper readers are using newspaper for different motivations. Gaining information, entertainment, leisure time activities, social integration is some motivations of media. Uses and gratifications theory asserts that reader is active part of communication process and reading habits figure on social and psychological needs. Items from readers’gratifications are categorized by using factor analysis from questionnair...

  13. EDMC: An enhanced distributed multi-channel anti-collision algorithm for RFID reader system

    Zhang, YuJing; Cui, Yinghua


    In this paper, we proposes an enhanced distributed multi-channel reader anti-collision algorithm for RFID environments which is based on the distributed multi-channel reader anti-collision algorithm for RFID environments (called DiMCA). We proposes a monitor method to decide whether reader receive the latest control news after it selected the data channel. The simulation result shows that it improves interrogation delay.

  14. Identification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer.

    Clermont, Pier-Luc; Crea, Francesco; Chiang, Yan Ting; Lin, Dong; Zhang, Amy; Wang, James Z L; Parolia, Abhijit; Wu, Rebecca; Xue, Hui; Wang, Yuwei; Ding, Jiarui; Thu, Kelsie L; Lam, Wan L; Shah, Sohrab P; Collins, Colin C; Wang, Yuzhuo; Helgason, Cheryl D


    While localized prostate cancer (PCa) can be effectively cured, metastatic disease inevitably progresses to a lethal state called castration-resistant prostate cancer (CRPC). Emerging evidence suggests that aberrant epigenetic repression by the polycomb group (PcG) complexes fuels PCa progression, providing novel therapeutic opportunities. In the search for potential epigenetic drivers of CRPC, we analyzed the molecular profile of PcG members in patient-derived xenografts and clinical samples. Overall, our results identify the PcG protein and methyl-lysine reader CBX2 as a potential therapeutic target in advanced PCa. We report that CBX2 was recurrently up-regulated in metastatic CRPC and that elevated CBX2 expression was correlated with poor clinical outcome in PCa cohorts. Furthermore, CBX2 depletion abrogated cell viability and induced caspase 3-mediated apoptosis in metastatic PCa cell lines. Mechanistically explaining this phenotype, microarray analysis in CBX2-depleted cells revealed that CBX2 controls the expression of many key regulators of cell proliferation and metastasis. Taken together, this study provides the first evidence that CBX2 inhibition induces cancer cell death, positioning CBX2 as an attractive drug target in lethal CRPC.

  15. Connected text reading and differences in text reading fluency in adult readers.

    Sebastian Wallot

    Full Text Available The process of connected text reading has received very little attention in contemporary cognitive psychology. This lack of attention is in parts due to a research tradition that emphasizes the role of basic lexical constituents, which can be studied in isolated words or sentences. However, this lack of attention is in parts also due to the lack of statistical analysis techniques, which accommodate interdependent time series. In this study, we investigate text reading performance with traditional and nonlinear analysis techniques and show how outcomes from multiple analyses can used to create a more detailed picture of the process of text reading. Specifically, we investigate reading performance of groups of literate adult readers that differ in reading fluency during a self-paced text reading task. Our results indicate that classical metrics of reading (such as word frequency do not capture text reading very well, and that classical measures of reading fluency (such as average reading time distinguish relatively poorly between participant groups. Nonlinear analyses of distribution tails and reading time fluctuations provide more fine-grained information about the reading process and reading fluency.

  16. Pro-poor growth and gender inequality

    Klasen, Stephan


    This paper examines to what extent gender gaps in education, health, employment, productive assets and inputs can affect pro poor growth (in the sense of increasing monetary incomes of the poor). After discussing serious methodological problems with examining gender issues in the context of an income-based pro-poor growth framework, the paper considers theory and evidence on the impact of gender inequality on pro poor growth. While there is a considerable literature suggesting negative impact...

  17. Training readers at school: the educational project, the school library and the mediation

    Rovilson José da Silva


    Full Text Available Introduction: Discusses the formation of readers in the first years of elementary school and proposes the integration between the school pedagogical project, teachers, reading practices and the school library. Objective: To analyze the basic assumptions to train readers in school. Methods: Bibliographic research based on a literature review on the subject. Results: Initial elements that may be used to structure readers-training projects at any schools are presented. Conclusion: Training readers at school consists in having procedures and pedagogical actions performed in combination with guided and free usage of the library, borrowing books and time to hear stories and talk about them.

  18. The Usefulness Metrics of The Most Popular eReader Used by Higher Education Students

    Dwi Puspita Sari


    Full Text Available In the digital technology era, mobile devices have an important rule to deploy a copy of data and information through the network. An electronic reader (eReader allows readers to read written materials in an electronic manner that is available in many models. The objective of this study is to evaluate the usage of eReader by higher education students. We firstly identified the most frequently used eReader by surveying higher education students. The survey results showed that Apple iPad, Amazon Kindle, and Samsung Tablet are the most popular eReader devices used by higher education students. We presented these results, and then we analyzed the surveyed results in detail in order to develop an evaluation metric of the eReader in a mobile platform that clearly allows the selection of the most suitable eReader for higher education students. The main contribution of this paper is the development of a set of criteria that can be used by students in the selection of an eReader that matches their specific needs and requirements.

  19. Modeling individual differences in text reading fluency: a different pattern of predictors for typically developing and dyslexic readers

    Pierluigi eZoccolotti


    Full Text Available This study was aimed at predicting individual differences in text reading fluency. The basic proposal included two factors, i.e., the ability to decode letter strings (measured by discrete pseudo-word reading and integration of the various sub-components involved in reading (measured by Rapid Automatized Naming, RAN. Subsequently, a third factor was added to the model, i.e., naming of discrete digits. In order to use homogeneous measures, all contributing variables considered the entire processing of the item, including pronunciation time. The model, which was based on commonality analysis, was applied to data from a group of 43 typically developing readers (11- to 13-year-olds and a group of 25 chronologically matched dyslexic children. In typically developing readers, both orthographic decoding and integration of reading sub-components contributed significantly to the overall prediction of text reading fluency. The model prediction was higher (from ca. 37% to 52% of the explained variance when we included the naming of discrete digits variable, which had a suppressive effect on pseudo-word reading. In the dyslexic readers, the variance explained by the two-factor model was high (69% and did not change when the third factor was added. The lack of a suppression effect was likely due to the prominent individual differences in poor orthographic decoding of the dyslexic children. Analyses on data from both groups of children were replicated by using patches of colours as stimuli (both in the RAN task and in the discrete naming task obtaining similar results. We conclude that it is possible to predict much of the variance in text-reading fluency using basic processes, such as orthographic decoding and integration of reading sub-components, even without taking into consideration higher-order linguistic factors such as lexical, semantic and contextual abilities. The approach validity of using proximal vs distal causes to predict reading fluency is

  20. Neutral vs positive oral contrast in diagnosing acute appendicitis with contrast-enhanced CT: sensitivity, specificity, reader confidence and interpretation time

    Naeger, D M; Chang, S D; Kolli, P; Shah, V; Huang, W; Thoeni, R F


    Objective The study compared the sensitivity, specificity, confidence and interpretation time of readers of differing experience in diagnosing acute appendicitis with contrast-enhanced CT using neutral vs positive oral contrast agents. Methods Contrast-enhanced CT for right lower quadrant or right flank pain was performed in 200 patients with neutral and 200 with positive oral contrast including 199 with proven acute appendicitis and 201 with other diagnoses. Test set disease prevalence was 50%. Two experienced gastrointestinal radiologists, one fellow and two first-year residents blindly assessed all studies for appendicitis (2000 readings) and assigned confidence scores (1=poor to 4=excellent). Receiver operating characteristic (ROC) curves were generated. Total interpretation time was recorded. Each reader's interpretation with the two agents was compared using standard statistical methods. Results Average reader sensitivity was found to be 96% (range 91–99%) with positive and 95% (89–98%) with neutral oral contrast; specificity was 96% (92–98%) and 94% (90–97%). For each reader, no statistically significant difference was found between the two agents (sensitivities p-values >0.6; specificities p-values>0.08), in the area under the ROC curve (range 0.95–0.99) or in average interpretation times. In cases without appendicitis, positive oral contrast demonstrated improved appendix identification (average 90% vs 78%) and higher confidence scores for three readers. Average interpretation times showed no statistically significant differences between the agents. Conclusion Neutral vs positive oral contrast does not affect the accuracy of contrast-enhanced CT for diagnosing acute appendicitis. Although positive oral contrast might help to identify normal appendices, we continue to use neutral oral contrast given its other potential benefits. PMID:20959365

  1. Cross-Language Modulation of Visual Attention Span: An Arabic-French-Spanish Comparison in Skilled Adult Readers.

    Awadh, Faris H R; Phénix, Thierry; Antzaka, Alexia; Lallier, Marie; Carreiras, Manuel; Valdois, Sylviane


    In delineating the amount of orthographic information that can be processed in parallel during a single fixation, the visual attention (VA) span acts as a key component of the reading system. Previous studies focused on the contribution of VA span to normal and pathological reading in monolingual and bilingual children from different European languages, without direct cross-language comparison. In the current paper, we explored modulations of VA span abilities in three languages -French, Spanish, and Arabic- that differ in transparency, reading direction and writing systems. The participants were skilled adult readers who were native speakers of French, Spanish or Arabic. They were administered tasks of global and partial letter report, single letter identification and text reading. Their VA span abilities were assessed using tasks that require the processing of briefly presented five consonant strings (e.g., R S H F T). All five consonants had to be reported in global report but a single cued letter in partial report. Results showed that VA span was reduced in Arabic readers as compared to French or Spanish readers who otherwise show a similar high performance in the two report tasks. The analysis of VA span response patterns in global report showed a left-right asymmetry in all three languages. A leftward letter advantage was found in French and Spanish but a rightward advantage in Arabic. The response patterns were symmetric in partial report, regardless of the language. Last, a significant relationship was found between VA span abilities and reading speed but only for French. The overall findings suggest that the size of VA span, the shape of VA span response patterns and the VA Span-reading relationship are modulated by language-specific features.

  2. Cross-language modulation of visual attention span: An Arabic-French-Spanish comparison in adult skilled readers.

    Faris Haroon Rasheed Awadh


    Full Text Available In delineating the amount of orthographic information that can be processed in parallel during a single fixation, the visual attention (VA span acts as a key component of the reading system. Previous studies focused on the contribution of VA span to normal and pathological reading in monolingual and bilingual children from different European languages, without direct cross-language comparison. In the current paper, we explored modulations of VA span abilities in three languages --French, Spanish and Arabic-- that differ in transparency, reading direction and writing systems. The participants were adult skilled readers who were native speakers of French, Spanish or Arabic. They were administered tasks of global and partial letter report, single letter identification and text reading. Their VA span abilities were assessed using tasks that require the processing of briefly presented 5 consonant strings (e.g., R S H F T. All five consonants had to be reported in global report but a single cued letter in partial report. Results showed that the VA span was reduced in Arabic readers as compared to French or Spanish readers who otherwise show a similar high performance in the two report tasks. The analysis of VA span response patterns in global report showed a left-right asymmetry in all three languages. A leftward letter advantage was found in French and Spanish but a rightward advantage in Arabic. The response patterns were symmetric in partial report, regardless of the language. Last, a significant relationship was found between visual attention span abilities and reading speed but only for French. The overall findings suggest that the size of VA span, the shape of VA span response patterns and the VA Span-reading relationship are modulated by language-specific features.

  3. What characterizes persons with poor mental health?

    Christensen, Anne Illemann; Davidsen, Michael; Kjøller, Mette


    analysed by means of logistic regression models. Results: Men and women with poor mental health are characterized by being single, having a long-term illness, not being able to rely on help from others in case of illness and by feeling that family and friends demand too much of them. Men with poor mental...... health were further characterized by being a heavy smoker, and having a BMI below 25. Women with poor mental health were further characterized by being 16-44 years old and sedentary in leisure time. CONCLUSIONS THE PREVALENCE OF POOR MENTAL HEALTH IS HIGHER AMONG WOMEN THAN MEN, AND DIFFERENT FACTORS...... CHARACTERIZE MEN AND WOMEN WITH POOR MENTAL HEALTH THE PRESENT FINDINGS SUPPORT THE NOTION THAT BOTH SOCIO-DEMOGRAPHICS AND LIFESTYLE FACTORS ARE INDEPENDENTLY RELATED WITH POOR MENTAL HEALTH WE SUGGEST TAKING INTO ACCOUNT ALL THESE AREAS OF LIFE WHEN PLANNING ACTIVITIES TO PREVENT POOR MENTAL HEALTH AND WHEN...

  4. Diagnostic accuracy of mammography readers and their memory performance have no correlation with each other

    Kok, P.; Cawson, J.N.; Mercuri, V.; Pitman, A.G.; Gledhill, S.; Shnier, D.; Taft, R.; Zentner, L.


    Full text: The study aims to determine if any association exists between visual memory performance and diagnostic accuracy performance in a group of radiologist mammogram readers. Materials and Methods: One hundred proven mammograms (23 with cancers) were grouped into 5 sets of 20 cases, with sets being of equal difficulty. Pairs of sets were presented in 5 reads (40 cases per read, order random) to a panel of 8 radiologist readers (either present or past screening readers, with experience range from 20 years). The readers were asked to either 'clear' or 'call back' cases depending on need for further workup, and at post-baseline reads to indicate whether each case was 'new' or 'old' (i .e. remembered from prior read). Two sets were presented only at baseline (40 cases per reader), and were used to calculate the reader's false recollection rate. Three sets were repeated post-baseline once or twice (100 cases per reader). Reading conditions were standardised. Results: Memory performance differed markedly between readers. The number of correctly remembered cases (of 100 'old' cases) had a median of 10.5 and range of 0-58. The observed number of false recollections (of 40 'totally new' cases) had a median of 2 and range of 0-17. Diagnostic performance measures were mean (range): sensitivity 0.68 (0.54-0.81); specificity 0.82 (0.74-0.91); positive predictive value (PPV) 0.55 (0.500.65); negative predictive value (NPV) 0.89 (0.86-0.93) and accuracy 0.78 (0.76-0.83). Confidence intervals (CIs; 95%) for each reader overlapped for all the diagnostic parameters, indicating a lack of statistically significant difference between the readers at the 5% level. The most sensitive and the most specific reader showed a trend away from each other on sensitivity, specificity, NPV and PPV; their accuracies were 0.76 and 0.82, respectively, and their accuracy 95% CIs overlapped considerably. Correlation analysis by reader showed no association between observed memory performance and

  5. The effect of Rational Emotive Behaviour Therapy (REBT) on poor ...

    Research has identified Poor study habits as one of the key factors responsible for this high rate of failure and widespread examination malpractice among students. REBT is a cognitive behavior therapy that deals with modifying maladjusted behavior that has to do with a faulty belief system. The purpose of this study is to ...

  6. Development of fuel number reader by ultrasonic imaging techniques

    Omote, T.; Yoshida, T.


    This paper reports on a spent fuel ID number reader using ultrasonic imaging techniques that has been developed to realize efficient and automatic verification of fuel numbers, thereby to reduce mental load and radiation exposure for operators engaged in the verification task. The ultrasonic imaging techniques for automatic fuel number recognition are described. High-speed and high reliability imaging of the spent fuel ID number are obtained by using linear array type ultrasonic probe. The ultrasonic wave is scanned by switching array probe in vertical direction, and scanned mechanically in horizontal direction. Time for imaging of spent fuel ID number on assembly was confirmed less than three seconds by these techniques. And it can recognize spent fuel ID number even if spent fuel ID number can not be visualized by an optical method because of depositing fuel number regions by soft card. In order to recognize spent fuel ID number more rapidly and more reliably, coded fuel number expressed by plural separate recesses form is developed. Every coded fuel number consists of six small holes (about 1 mm dia.) and can be marked adjacent to the existing fuel number expressed by letters and numbers

  7. Letter position coding across modalities: the case of Braille readers.

    Manuel Perea

    Full Text Available The question of how the brain encodes letter position in written words has attracted increasing attention in recent years. A number of models have recently been proposed to accommodate the fact that transposed-letter stimuli like jugde or caniso are perceptually very close to their base words.Here we examined how letter position coding is attained in the tactile modality via Braille reading. The idea is that Braille word recognition may provide more serial processing than the visual modality, and this may produce differences in the input coding schemes employed to encode letters in written words. To that end, we conducted a lexical decision experiment with adult Braille readers in which the pseudowords were created by transposing/replacing two letters.We found a word-frequency effect for words. In addition, unlike parallel experiments in the visual modality, we failed to find any clear signs of transposed-letter confusability effects. This dissociation highlights the differences between modalities.The present data argue against models of letter position coding that assume that transposed-letter effects (in the visual modality occur at a relatively late, abstract locus.

  8. Index finger somatosensory evoked potentials in blind Braille readers.

    Giriyappa, Dayananda; Subrahmanyam, Roopakala Mysore; Rangashetty, Srinivasa; Sharma, Rajeev


    Traditionally, vision has been considered the dominant modality in our multi-sensory perception of the surrounding world. Sensory input via non-visual tracts becomes of greater behavioural relevance in totally blind individuals to enable effective interaction with the world around them. These include audition and tactile perceptions, leading to an augmentation in these perceptions when compared with normal sighted individuals. The objective of the present work was to study the index finger somatosensory evoked potentials (SEPs) in totally blind and normal sighted individuals. SEPs were recorded in 15 Braille reading totally blind females and compared with 15 age-matched normal sighted females. Latency and amplitudes of somatosensory evoked potential waveforms (N9, N13, and N20) were measured. Amplitude of N20 SEP (a cortical somatosensory evoked potential) was significantly larger in the totally blind than in normal sighted individuals (p Braille reading right index finger. Totally blind Braille readers have larger N20 amplitude, suggestive of greater somatosensory cortical representation of the Braille reading index finger.

  9. Letter position coding across modalities: the case of Braille readers.

    Perea, Manuel; García-Chamorro, Cristina; Martín-Suesta, Miguel; Gómez, Pablo


    The question of how the brain encodes letter position in written words has attracted increasing attention in recent years. A number of models have recently been proposed to accommodate the fact that transposed-letter stimuli like jugde or caniso are perceptually very close to their base words. Here we examined how letter position coding is attained in the tactile modality via Braille reading. The idea is that Braille word recognition may provide more serial processing than the visual modality, and this may produce differences in the input coding schemes employed to encode letters in written words. To that end, we conducted a lexical decision experiment with adult Braille readers in which the pseudowords were created by transposing/replacing two letters. We found a word-frequency effect for words. In addition, unlike parallel experiments in the visual modality, we failed to find any clear signs of transposed-letter confusability effects. This dissociation highlights the differences between modalities. The present data argue against models of letter position coding that assume that transposed-letter effects (in the visual modality) occur at a relatively late, abstract locus.

  10. An Analysis of Practical Lexicography: A Reader (Ed. Fontenelle 2008

    Gilles-Maurice de Schryver


    Full Text Available

    Abstract: Intended as a companion volume to The Oxford Guide to Practical Lexicography (Atkins and Run-dell 2008, Fontenelle's book aims to bring together the most relevant papers in practical lexicography. This review article presents a critical analysis of the success thereof, both in quantitative and qualitative terms.


    Samenvatting: Een analyse van Practical Lexicography: A Reader (Fonte-nelle 2008. Bedoeld als achtergrondlectuur bij The Oxford Guide to Practical Lexicography (Atkins en Rundell 2008, is het doel van Fontenelle's boek om de meest relevante papers m.b.t. praktische lexicografie samen te brengen. Dit recensieartikel is een kritische analyse van het succes daarvan, zowel in kwantitatieve als kwalitatieve termen.


  11. Gauge theories of gravitation a reader with commentaries

    Blagojevic, Milutin


    In the last five decades, the gauge approach to gravity has represented a research area of increasing importance for our understanding of the physics of fundamental interactions. A full clarification of the gauge dynamics of gravity is expected to be the last missing link to the hidden structure of a consistent unification of all the fundamental interactions, based on the gauge principle. The aim of the present reprint volume, with commentaries by Milutin Blagojevi & 263; and Friedrich W Hehl, is to introduce graduate and advanced undergraduate students of theoretical or mathematical physics, or any other interested researcher, to the field of classical gauge theories of gravity. This is not just an ordinary reprint volume; it is a guide to the literature on gauge theories of gravity. The reader is encouraged first to study the introductory commentaries and to become familiar with the basic content of the reprints and related ideas, then he/she can choose to read a specific reprint or reprints, and after ...

  12. The Birthing of Things: Bergson as a Reader of Lucretius

    Patrick Healy


    Full Text Available I examine, in this short paper, the work of Henri Bergson on Lucretius first published in 1884, and argue for its vital significance in understanding the development of his philosophical thinking. This publication was to serve as an introduction to extracts from Lucretius, for his students at Clermont-Ferrand, with a commentary and notes on the poetry, philosophy, the physics, language and text of his poem De Rerum Natura. In the published volume most of the overview of Lucretius by Bergson is given in the long preface, and this is followed by extracts in Latin, without translation into French, with comments on lines and individual words, which covers all the books of the original poem. By 1899 it had gone to a third edition, and was still in print until the 1960's. Copies today are very difficult to obtain, and only recently has a full electronic version become available on the Internet Archive, to which readers are here directly referred.

  13. A portable eBook reader for the blind.

    Velazquez, Ramiro; Hernandez, Hermes; Preza, Enrique


    This paper presents the design and first prototype of the TactoBook system, a novel concept of reading assistive device that aims to make eBooks accessible to the blind. The TactoBook consists of a computer-based software translator that converts fast and automatically any eBook into Braille. The Braille version of the eBook is then encrypted as a file and stored in a USB memory drive which is later inserted and reproduced in a compact, lightweight, and highly-portable tactile terminal. Braille readers can store multiple eBooks in the same USB and access/reproduce them in the tactile terminal without this being plugged to a computer. The first Braille terminal developed is a 10-cell prototype based on a piezoelectric ultrasonic actuation approach. Its overall performance is quite similar to the one obtained with traditional Braille terminals. However, unlike them, the full device is only 1 kg mass and its compact dimensions (20 × 15 × 10 cm) make it easily carried by the user. A technical overview of all subsystems is presented and discussed.

  14. Social Media Blurred the Distinction Between Author and Reader

    Lambiotte, Renaud

    The last few years have seen the emergence of the sharing economy. As social media blurred the distinction between author and reader, everyone can now offer or receive services thanks to the networking tools provided by new technological companies. Take Uber, and its billion of journeys in 2015 alone, with tens of thousands of vehicles crawling every moment in the globe's biggest cities. As often, when confronted with a technological change, we observe a polarization of society, and the search for an equilibrium characterized by new norms, rights, and obligations. Understanding the mechanisms behind this re-organization requires an integrated, interdisciplinary approach, covering an intricate web of legal, societal, economical, and computational issues which, we believe, could benefit from a complex systems perspective. As a first step, we are currently studying the dynamics of pricing in Uber. In this new de-regulated world, journey prices fluctuate in time depending on traffic but also on the service's perceived balance of passenger demand and driver supply...

  15. Seamless lesion insertion in digital mammography: methodology and reader study

    Pezeshk, Aria; Petrick, Nicholas; Sahiner, Berkman


    Collection of large repositories of clinical images containing verified cancer locations is costly and time consuming due to difficulties associated with both the accumulation of data and establishment of the ground truth. This problem poses a significant challenge to the development of machine learning algorithms that require large amounts of data to properly train and avoid overfitting. In this paper we expand the methods in our previous publications by making several modifications that significantly increase the speed of our insertion algorithms, thereby allowing them to be used for inserting lesions that are much larger in size. These algorithms have been incorporated into an image composition tool that we have made publicly available. This tool allows users to modify or supplement existing datasets by seamlessly inserting a real breast mass or micro-calcification cluster extracted from a source digital mammogram into a different location on another mammogram. We demonstrate examples of the performance of this tool on clinical cases taken from the University of South Florida Digital Database for Screening Mammography (DDSM). Finally, we report the results of a reader study evaluating the realism of inserted lesions compared to clinical lesions. Analysis of the radiologist scores in the study using receiver operating characteristic (ROC) methodology indicates that inserted lesions cannot be reliably distinguished from clinical lesions.

  16. The Experiences in Processing Policies and Contracts by Adult ESL Readers

    Abiog, Evalyn B.


    The present study describes the experiences of adult English as a Second Language (ESL) readers in processing legal texts prior to entering a financial agreement. A preliminary survey was conducted to determine the commonly read policies and contracts of adult ESL reader-consumers, which revealed those of banks and life-insurance companies; hence,…

  17. The Effect of Technology-Based Altered Readability Levels on Struggling Readers' Science Comprehension

    Marino, Matthew T.; Coyne, Michael; Dunn, Michael


    This article reports findings from a study examining how altered readability levels affected struggling readers' (N = 288) comprehension of scientific concepts and vocabulary. Specifically, the researchers were interested in learning what effect altered readability levels have when low ability readers participate in a technology-based science…

  18. Expository Text Comprehension in Secondary School: For Which Readers Does Knowledge of Connectives Contribute the Most?

    Welie, Camille; Schoonen, Rob; Kuiken, Folkert; Bergh, Huub


    The present study examined whether knowledge of connectives contributes uniquely to expository text comprehension above and beyond reading fluency, general vocabulary knowledge and metacognitive knowledge. Furthermore, it was examined whether this contribution differs for readers with different language backgrounds or readers who vary in reading…

  19. Selecting "App"ealing and "App"ropriate Book Apps for Beginning Readers

    Cahill, Maria; McGill-Franzen, Anne


    Beginning with a brief rationale for selecting quality digital picture book apps for beginning readers, the authors describe the elements of digital picture books and provide a brief review of the instructional benefits of digital picture book use for beginning readers. They then present a detailed taxonomy for selecting quality picture book apps.…

  20. Syntactic and Discourse Skills in Chinese Adolescent Readers with Dyslexia: A Profiling Study

    Chung, Kevin K. H.; Lo, Jason C. M.; Ho, Connie S.-H.; Xiao, Xiaoyun; Chan, David W.


    This study aims to investigate the relation of syntactic and discourse skills to morphological skills, rapid naming, and working memory in Chinese adolescent readers with dyslexia and to examine their cognitive-linguistic profiles. Fifty-two dyslexic readers (mean age, 13;42) from grade 7 to 9 in Hong Kong high schools were compared with 52…

  1. So Long, Robot Reader! A Superhero Intervention Plan for Improving Fluency

    Marcell, Barclay; Ferraro, Christine


    This article presents an engaging means for turning disfluent readers into prosody superstars. Each week students align with Poetry Power Man and his superhero friends to battle the evil Robot Reader and his sidekicks. The Fluency Foursome helps students adhere to the multidimensional aspects of fluency where expression and comprehension are…

  2. Developing Historical Reading and Writing with Adolescent Readers: Effects on Student Learning

    De La Paz, Susan; Felton, Mark; Monte-Sano, Chauncey; Croninger, Robert; Jackson, Cara; Deogracias, Jeehye Shim; Hoffman, Benjamin Polk


    In this study, the effects of a disciplinary reading and writing curriculum intervention with professional development are shared. We share our instructional approach and provide writing outcomes for struggling adolescent readers who read at or below basic proficiency levels, as well as writing outcomes for proficient and advanced readers.…

  3. Design and trial evaluation of the user interface for MusicReader

    Leoné, Marco; van Dijk, Elisabeth M.A.G.; van Beijnum, Bernhard J.F.


    This paper describes the design and trial results of MusicReader, a networked application realizing sheet music related services for the support of ensemble and orchestra rehearsals and performances. To this end, MusicReader presents sheet music on computer screens and supports annotations, sheet

  4. Metacognitive Online Reading Strategy Use: Readers' Perceptions in L1 and L2

    Taki, Saeed


    This study aimed to explore whether first-language (L1) readers of different language backgrounds would employ similar metacognitive online reading strategies and whether reading online in a second language (L2) could be influenced by L1 reading strategies. To this end, 52 Canadian college students as English L1 readers and 38 Iranian university…

  5. News in online and print newspapers: Differences in reader consumption and recall

    d'Haenens, Leen; Jankowski, Nicholas; Heuvelman, A.


    How readers consume and recall news presented in online and print versions of two newspapersin the Netherlands are investigated in this experimental study. Few differences are found between the online and print versions in terms of news supply. Reader attention to the news stories varies, depending

  6. Teaching Early Readers to Self-Monitor and Self-Correct

    Pratt, Sharon M.; Urbanowski, Melena


    Proficient readers self-monitor and self-correct to derive meaning from text. This article reviews research on how students learn to self-monitor and self-correct and describes a Reciprocal Teaching (RT) instructional routine that was successfully used with early readers to build their metacognitive processes. The RT routine included teacher…

  7. Professional writers and empathy: Exploring the barriers to anticipating reader problems

    de Jong, Menno D.T.; Lentz, Leo


    Research has shown that professional writers cannot accurately predict the problems readers will experience when using functional documents. In this paper, we give an overview of reasons why it can be so hardfor writers to anticipate reader problems. We elaborate on the concept of empathy, and

  8. Short Vowels versus Word Familiarity in the Reading Comprehension of Arab Readers: A Revisited Issue

    Seraye, Abdullah M.


    Arab readers, both beginning and advanced, are encouraged to read and accustomed to unvowelized and undiacriticized texts. Previous literature claimed that the presence of short vowels in the text would facilitate the reading comprehension of both beginning and advanced Arab readers. However, with a claimed strict controlling procedure, different…

  9. Acquisition of Malay Word Recognition Skills: Lessons from Low-Progress Early Readers

    Lee, Lay Wah; Wheldall, Kevin


    Malay is a consistent alphabetic orthography with complex syllable structures. The focus of this research was to investigate word recognition performance in order to inform reading interventions for low-progress early readers. Forty-six Grade 1 students were sampled and 11 were identified as low-progress readers. The results indicated that both…

  10. Relations among Metamemory, Rehearsal Activity and Word Recall of Learning Disabled and Non-Disabled Readers.

    Swanson, H.L.


    In free recall of word lists involving different rehearsal strategies, more words were recalled by older (as against younger) children and by nondisabled (as against learning disabled) readers. Disabled readers tended to be nonstrategic recallers and less accurate estimators of their memory capacity. Recall differences were attributed to semantic…

  11. Examining the Effects of School-Provided E-Readers on Middle School Students' Reading Ability

    Brown, H. Quincy


    Nationwide, the increasing popularity of e-books is undeniable; sales of e-books increased an astounding 4,456% over a 5-year period. Researchers, Miranda, Johnson, and Rossi-Williams, determined that e-readers have a positive impact on students' desire to read. This study attempted to determine if the use of institution issued e-readers would…

  12. Designs of Concept Maps and Their Impacts on Readers' Performance in Memory and Reasoning while Reading

    Tzeng, Jeng-Yi


    From the perspective of the Fuzzy Trace Theory, this study investigated the impacts of concept maps with two strategic orientations (comprehensive and thematic representations) on readers' performance of cognitive operations (such as perception, verbatim memory, gist reasoning and syntheses) while the readers were reading two history articles that…

  13. A Dual-Route Perspective on Eye Movements of Dyslexic Readers

    Hawelka, Stefan; Gagl, Benjamin; Wimmer, Heinz


    This study assessed eye movement abnormalities of adolescent dyslexic readers and interpreted the findings by linking the dual-route model of single word reading with the E-Z Reader model of eye movement control during silent sentence reading. A dysfunction of the lexical route was assumed to account for a reduced number of words which received…

  14. Predictors of Reading Comprehension among Struggling Readers Who Exhibit Differing Levels of Inattention and Hyperactivity

    Swanson, Elizabeth; Barnes, Marcia; Fall, Anna-Mari; Roberts, Greg


    The purpose of this study was to investigate the impact of inference making, decoding, memory, and vocabulary on reading comprehension among 7th- through 12th-grade struggling readers with varying levels of inattention and hyperactivity. We categorized a group of 414 struggling readers into 3 groups based on results from factor mixture modeling:…

  15. Literature Discussion: Encouraging Reading Interest and Comprehension in Struggling Middle School Readers

    Pittman, Pamela; Honchell, Barbara


    The purpose of this qualitative study was to explore how literature discussion affects middle school struggling readers. The focus was on 16 middle school struggling readers in a rural Title I school in the southeastern United States. Findings indicated that (a) literature discussion increased student enjoyment of reading, and (b) students…

  16. Measuring the Reader Self-Perceptions of Adolescents: Introducing the RSPS2

    Henk, William A.; Marinak, Barbara A.; Melnick, Steven A.


    This paper introduces a new affective instrument for assessing the reader self-perceptions of students in grades seven through ten. The Reader Self-Perception Scale 2 (RSPS2) builds upon its predecessor, the RSPS, a tool that measures the reading efficacy beliefs of children in grades four through six. New items were created for the RSPS2 to…

  17. Making Connections: Linking Cognitive Psychology and Intervention Research to Improve Comprehension of Struggling Readers

    McMaster, Kristen L.; Espin, Christine A.; van den Broek, Paul


    Many studies have demonstrated the efficacy of reading comprehension interventions for struggling readers, including students with learning disabilities. Yet, some readers continue to struggle with comprehension despite receiving these interventions. In this article, we argue that an explicit link between cognitive psychology and intervention…

  18. Low Access Delay Anti-Collision Algorithm for Reader in RFID systems

    Galiotto, Carlo; Marchetti, Nicola; Prasad, Neeli R.


    Radio Frequency Identification (RFID) is a technology which is spreading more and more as a medium to identify, locate and track assets through the productive chain. As all the wireless communication devices sharing the same transmission channel, RFID readers and tags experience collisions whenever...... deployed over the same area. In this work, the RFID reader collision problem is studied and a centralized scheduling-based algorithm is proposed as possible candidate solution, especially for those scenarios involving static or low mobility readers. Taking into account the circuitry limitations of the tags......, which do not allow to use frequency or code division multiple access schemes in the RFID systems, this paper proposes an algorithm aiming to prevent the readers collisions, while keeping the access delay of the readers to the channel possibly low. The simulation results show that this algorithm performs...

  19. WellReader: a MATLAB program for the analysis of fluorescence and luminescence reporter gene data.

    Boyer, Frédéric; Besson, Bruno; Baptist, Guillaume; Izard, Jérôme; Pinel, Corinne; Ropers, Delphine; Geiselmann, Johannes; de Jong, Hidde


    Fluorescent and luminescent reporter gene systems in combination with automated microplate readers allow real-time monitoring of gene expression on the population level at high precision and sampling density. This generates large amounts of data for the analysis of which computer tools are missing to date. We have developed WellReader, a MATLAB program for the analysis of fluorescent and luminescent reporter gene data. WellReader allows the user to load the output files of microplate readers, remove outliers, correct for background effects and smooth and fit the data. Moreover, it computes biologically relevant quantities from the measured signals, notably promoter activities and protein concentrations, and compares the resulting expression profiles of different genes under different conditions. WellReader is available under a LGPL licence at

  20. Nanosuspension Technology for Solubilizing Poorly Soluble Drugs

    Deoli Mukesh


    Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. It is estimated that around 40% of drugs in the pipeline cannot be delivered through the preferred route or in some cases, at all owing to poor water solubility. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor1 EL). To date, nanoscale systems f...


    Alexander S. Komarov


    Full Text Available The article is devoted to some strategies aimed at involving the reader into the writer's book by means of making the reader's attitude to its content personal or subjective. In the article it is stated that there are two components which are intrinsic to virtual intercourse between writer and reader. One of the components is the content of the writer's publication while the other is the reader's attitude towards the content suggested. The article shows that the reader's attitude encompasses two processes: the process of self-estrangement from the writer's content and the process of self-involvement into it. In the article, the author analyses these two processes in relation to the content of the book. In the article, the author singles out and gives descriptions of such dimensions of the book's content as its topical and emotional dimension, its depth, human nature dimension and interpersonal relations dimension as well as of strategies used by the writer in order to involve the reader into his writings. The author argues that a successful strategy is based on managing to touch the reader to the quick, i.e. his or her subjectivity, and the result of successfulness can be measured by the reader's readiness and willingness to sink into one of the dimensions suggested. The author of the article comes to the conclusion that signs of the successful strategy can be traced in the reader's return to the intercourse with the writer when he or she rereads the writer's books, repeats or makes references to words, situations or ideas suggested or described by the writer who has grasped the reader's attention in one or several content dimensions.

  2. Scanometry as microplate reader for high throughput method based on DPPH dry reagent for antioxidant assay

    Mochammad Amrun Hidayat


    Full Text Available The stable chromogenic radical 1,1′-diphenyl-2-picrylhydrazyl (DPPH solution was immobilized on the microwell plate as dry reagent to construct a simple antioxidant sensor. Then, a regular flatbed scanner was used as microplate reader to obtain analytical parameters for antioxidant assay using one-shot optical sensors as scanometry technique. Variables affecting the acquisition of the images were optimized and the analytical parameters are obtained from an area of the sensing zone inside microwell using the average luminosity of the sensing zone captured as the mean of red, green, and blue (RGB value using ImageJ® program. By using this RGB value as sensor response, it is possible to determine antioxidant capacity in the range 1–25 ppm as gallic acid equivalent (GAE with the response time of 9 min. The reproducibility of sensor was good (RSD<1% with recovery at 93%–96%. The antioxidant sensor was applied to the plant extracts, such as sappan wood and Turmeric Rhizome. The results are good when compared to the same procedure using a UV/Vis spectrophotometer.

  3. Nasa Unveils Cosmic Images Book in Braille for Blind Readers


    BALTIMORE - At a Tuesday ceremony at the National Federation of the Blind, NASA unveiled a new book that brings majestic images taken by its Great Observatories to the fingertips of the blind. "Touch the Invisible Sky" is a 60-page book with color images of nebulae, stars, galaxies and some of the telescopes that captured the original pictures. Each image is embossed with lines, bumps and other textures. These raised patterns translate colors, shapes and other intricate details of the cosmic objects, allowing visually impaired people to experience them. Braille and large-print descriptions accompany each of the book's 28 photographs, making the book's design accessible to readers of all visual abilities. Sample page Sample page The book contains spectacular images from the Hubble Space Telescope, Chandra X-ray Observatory, Spitzer Space Telescope and powerful ground-based telescopes. The celestial objects are presented as they appear through visible-light telescopes and different spectral regions invisible to the naked eye, from radio to infrared, visible, ultraviolet and X-ray light. The book introduces the concept of light and the spectrum and explains how the different observatories complement each others' findings. Readers take a cosmic journey beginning with images of the sun, and travel out into the galaxy to visit relics of exploding and dying stars, as well as the Whirlpool galaxy and colliding Antennae galaxies. People Who Read This Also Read... Chandra Data Reveal Rapidly Whirling Black Holes Jet Power and Black Hole Assortment Revealed in New Chandra Image Action Replay of Powerful Stellar Explosion Black Holes Are The Rhythm at The Heart of Galaxies "Touch the Invisible Sky" was written by astronomy educator and accessibility specialist Noreen Grice of You Can Do Astronomy LLC and the Museum of Science, Boston, with authors Simon Steel, an astronomer with the Harvard-Smithsonian Center for Astrophysics in Cambridge, Mass., and Doris Daou, an astronomer

  4. The Effect of the Reader's Background on Reading Comprehension Performance

    Bushra Saadoon Mohammed Al-Noori


    Full Text Available This study aims at measuring the amount of the effect of the reader's background knowledge on performance in reading comprehension tests through the assessment of information gained in reading comprehension (RC tests across-four testing techniques, short answer questions ,true-false items , multiple - choice items , and cloze test and re-test. This technique involves the examinees in two types of tasks, i.e. pre-reading and post -reading task. Two hypotheses have been proposed to achieve the aims of this study. They are  1-There are no significant differences between the pre-reading and post-reading performances of examinees on reading comprehension(RC. 2-There are no significant differences in information gain scores across the different techniques of testing reading comprehension (RC in EFL. To verify the validity of these two hypotheses, a number of statistical procedures have been used such as arithmetical mean, t-test for correlated and independent samples to analyze the performance of third and fourth year College students studying at the Department of English at University of Baghdad /Ibn Rushd College of Education for Humanities on two reading passages taken from TOEFL practice tests (2011. The analysis of the data has shown the following results: 1-The background knowledge has an effect on the performance on reading comprehension (RC. 2-There is a significant difference in students' performance on reading comprehension (RC. 3-The effect of background knowledge is investable on reading comprehension (RC tests, but it can be identified or neutralized. Based on these conclusions, the researcher presented a number of recommendations.

  5. RAC-Multi: Reader Anti-Collision Algorithm for Multichannel Mobile RFID Networks

    Kwangcheol Shin


    Full Text Available At present, RFID is installed on mobile devices such as mobile phones or PDAs and provides a means to obtain information about objects equipped with an RFID tag over a multi-channeled telecommunication networks. To use mobile RFIDs, reader collision problems should be addressed given that readers are continuously moving. Moreover, in a multichannel environment for mobile RFIDs, interference between adjacent channels should be considered. This work first defines a new concept of a reader collision problem between adjacent channels and then suggests a novel reader anti-collision algorithm for RFID readers that use multiple channels. To avoid interference with adjacent channels, the suggested algorithm separates data channels into odd and even numbered channels and allocates odd-numbered channels first to readers. It also sets an unused channel between the control channel and data channels to ensure that control messages and the signal of the adjacent channel experience no interference. Experimental results show that suggested algorithm shows throughput improvements ranging from 29% to 46% for tag identifications compared to the GENTLE reader anti-collision algorithm for multichannel RFID networks.

  6. Geometric Distribution-Based Readers Scheduling Optimization Algorithm Using Artificial Immune System

    Litian Duan


    Full Text Available In the multiple-reader environment (MRE of radio frequency identification (RFID system, multiple readers are often scheduled to interrogate the randomized tags via operating at different time slots or frequency channels to decrease the signal interferences. Based on this, a Geometric Distribution-based Multiple-reader Scheduling Optimization Algorithm using Artificial Immune System (GD-MRSOA-AIS is proposed to fairly and optimally schedule the readers operating from the viewpoint of resource allocations. GD-MRSOA-AIS is composed of two parts, where a geometric distribution function combined with the fairness consideration is first introduced to generate the feasible scheduling schemes for reader operation. After that, artificial immune system (including immune clone, immune mutation and immune suppression quickly optimize these feasible ones as the optimal scheduling scheme to ensure that readers are fairly operating with larger effective interrogation range and lower interferences. Compared with the state-of-the-art algorithm, the simulation results indicate that GD-MRSOA-AIS could efficiently schedules the multiple readers operating with a fairer resource allocation scheme, performing in larger effective interrogation range.

  7. Analytical validation of an ultra low-cost mobile phone microplate reader for infectious disease testing.

    Wang, Li-Ju; Naudé, Nicole; Demissie, Misganaw; Crivaro, Anne; Kamoun, Malek; Wang, Ping; Li, Lei


    Most mobile health (mHealth) diagnostic devices for laboratory tests only analyze one sample at a time, which is not suitable for large volume serology testing, especially in low-resource settings with shortage of health professionals. In this study, we developed an ultra-low-cost clinically-accurate mobile phone microplate reader (mReader), and clinically validated this optical device for 12 infectious disease tests. The mReader optically reads 96 samples on a microplate at one time. 771 de-identified patient samples were tested for 12 serology assays for bacterial/viral infections. The mReader and the clinical instrument blindly read and analyzed all tests in parallel. The analytical accuracy and the diagnostic performance of the mReader were evaluated across the clinical reportable categories by comparison with clinical laboratorial testing results. The mReader exhibited 97.59-99.90% analytical accuracy and envision the mReader can benefit underserved areas/populations and low-resource settings in rural clinics/hospitals at a low cost (~$50 USD) with clinical-level analytical quality. It has the potential to improve health access, speed up healthcare delivery, and reduce health disparities and education disparities by providing access to a low-cost spectrophotometer. Copyright © 2018 Elsevier B.V. All rights reserved.

  8. Cancer on a mammogram is not memorable: readers remember their recalls and not cancers

    Pitman, Alexander G.; Kok, Phebe; Zentner, Lucila


    To determine if presence of cancer on a mammogram makes that mammogram more memorable. A total of 100 mammograms (25 cancers) were grouped into 5 sets of 20 cases. Set pairs were presented in five reads to eight radiologist readers. Readers were asked to 'clear' or 'call back' cases, and at post-baseline reads to indicate whether each case was 'new' or 'old ' (remembered from prior read). Two sets were presented only at baseline, to calculate each reader's false recollection rate. For cases presented more than once ('old' cases, 100 presentations) readers could have 'correct memory' or 'memory loss'. Memory performance was defined as odds ratio of correct memory to memory loss. Multivariate logistic data regression analysis identified predictors of memory performance from: reader, set, time since last read, presence of cancer, and whether the case was called back at the last read. Memory performance differed markedly between readers and reader identity was a highly significant predictor of memory performance. Presence of cancer was not a significant predictor of memory performance (odds ratio 0.77, 95% CI: 0.49–1.21). Whether the case was called back at the last read was a highly significant predictor (odds ratio 4.22, 95% CI: 2.70–6.61) for the model incorporating reader variability, and also the model without reader variability (odds ratio 2.67, 95% CI: 1.74–4.08). The only statistically significant predictor of radiologist memory for a mammogram was whether the radiologist 'called it back' at a prior reading round. Presence of cancer on a mammogram did not make it memorable.

  9. Clofarabine in the treatment of poor risk acute myeloid leukaemia.

    Krawczyk, Janusz


    Clofarabine is a second generation nucleoside analogue. It inhibits DNA repair and activates the mitochondrial apoptotic pathway leading to cell death. In vitro clofarabine has demonstrated synergy with daunorubicin and Ara-C and in phase II clinical trials has shown promising activity in poor risk Acute myeloid leukaemia (AML) patients. In our institution over a 24 month period 22 AML patients (11 M, 11 F) with poor risk features, deemed unsuitable for standard therapy, were treated with clofarabine, alone (eight patients) or in combination (14 patients) for up to three cycles of treatment. The median age was 67.5 years (24-76) with 16 patients > 60 years. At the time of treatment 18 patients had active AML. Four patients intolerant of standard induction received clofarabine as consolidation. The overall response rate (ORR) for the 18 patients with active AML was 61%, nine patients (50%) achieving a complete response (CR). Induction and consolidation were well tolerated with no unexpected toxicities. Predictably, all patients developed grade 4 neutropenia but the median duration was only 20 days (17-120). Induction mortality was acceptable at 17%. In conclusion, clofarabine (alone or in combination) is active in poor risk AML with an acceptable safety profile and should be considered a potential option in poor risk AML patients.

  10. LH Pretreatment as a Novel Strategy for Poor Responders

    Anna Pia Ferraretti


    Full Text Available Introduction. Poor response to ovarian stimulation is still a major problem in IVF. The study presents a new stimulation protocol evaluated in a suppopulation of very difficult young poor ovarian responders. Material and Methods. The study consists in two sections. The first includes data from a randomized controlled study involving forty-three young patients with a poor ovarian response in at least two previous cycles (intended as cycle cancellation or with ≤3 collected oocytes. Patients were randomized in two groups: group A (control received FSH (400 IU/day, while group B received the new stimulation protocol consisting in a sequential association of 150 IU r-LH for 4 days followed by 400 IU r-FSH/after downregulation with daily GnRh agonist. The second includes data from the overall results in 65 patients treated with the new protocol compared to their previous performance with conventional cycles (historical control. Results. Both in the RCT and in the historical control study, LH pretreatment was able to decrease the cancellation rate, to improve the in vitro performance, and to significantly increase the live birth rates. Conclusions. LH pretreatment improved oocyte quantity and quality in young repeated poor responders selected in accordance with the Bologna criteria.

  11. An Effective Scheduling-Based RFID Reader Collision Avoidance Model and Its Resource Allocation via Artificial Immune Network

    Wang, Shanjin; Li, Zhonghua; He, Chunhui; Li, Jianming


    Radio frequency identification, that is, RFID, is one of important technologies in Internet of Things. Reader collision does impair the tag identification efficiency of an RFID system. Many developed methods, for example, the scheduling-based series, that are used to avoid RFID reader collision, have been developed. For scheduling-based methods, communication resources, that is, time slots, channels, and power, are optimally assigned to readers. In this case, reader collision avoidance is equ...

  12. Are preservice teachers prepared to teach struggling readers?

    Washburn, Erin K; Joshi, R Malatesha; Binks Cantrell, Emily


    Reading disabilities such as dyslexia, a specific learning disability that affects an individual's ability to process written language, are estimated to affect 15-20% of the general population. Consequently, elementary school teachers encounter students who struggle with inaccurate or slow reading, poor spelling, poor writing, and other language processing difficulties. However, recent evidence may suggest that teacher preparation programs are not providing preservice teachers with information about basic language constructs and other components related to scientifically based reading instruction. As a consequence preservice teachers have not exhibited explicit knowledge of such concepts in previous studies. Few studies have sought to assess preservice teachers' knowledge about dyslexia in conjunction with knowledge of basic language concepts. The purpose of the present study was to examine elementary school preservice teachers' knowledge of basic language constructs and their perceptions and knowledge about dyslexia. Findings from the present study suggest that preservice teachers, on average, are able to display implicit skills related to certain basic language constructs (i.e., syllable counting), but fail to demonstrate explicit knowledge of others (i.e., phonics principles). Also, preservice teachers seem to hold the common misconception that dyslexia is a visual perception deficit rather than a problem with phonological processing. Implications for future research as well as teacher preparation are discussed.

  13. Reading speed, comprehension and eye movements while reading Japanese novels: evidence from untrained readers and cases of speed-reading trainees.

    Hiromitsu Miyata

    Full Text Available BACKGROUND: A growing body of evidence suggests that meditative training enhances perception and cognition. In Japan, the Park-Sasaki method of speed-reading involves organized visual training while forming both a relaxed and concentrated state of mind, as in meditation. The present study examined relationships between reading speed, sentence comprehension, and eye movements while reading short Japanese novels. In addition to normal untrained readers, three middle-level trainees and one high-level expert on this method were included for the two case studies. METHODOLOGY/PRINCIPAL FINDINGS: In Study 1, three of 17 participants were middle-level trainees on the speed-reading method. Immediately after reading each story once on a computer monitor, participants answered true or false questions regarding the content of the novel. Eye movements while reading were recorded using an eye-tracking system. Results revealed higher reading speed and lower comprehension scores in the trainees than in the untrained participants. Furthermore, eye-tracking data by untrained participants revealed multiple correlations between reading speed, accuracy and eye-movement measures, with faster readers showing shorter fixation durations and larger saccades in X than slower readers. In Study 2, participants included a high-level expert and 14 untrained students. The expert showed higher reading speed and statistically comparable, although numerically lower, comprehension scores compared with the untrained participants. During test sessions this expert moved her eyes along a nearly straight horizontal line as a first pass, without moving her eyes over the whole sentence display as did the untrained students. CONCLUSIONS/SIGNIFICANCE: In addition to revealing correlations between speed, comprehension and eye movements in reading Japanese contemporary novels by untrained readers, we describe cases of speed-reading trainees regarding relationships between these variables

  14. The MAL-ED study: a multinational and multidisciplinary approach to understand the relationship between enteric pathogens, malnutrition, gut physiology, physical growth, cognitive development, and immune responses in infants and children up to 2 years of age in resource-poor environments.


    Highly prevalent conditions with multiple and complex underlying etiologies are a challenge to public health. Undernutrition, for example, affects 20% of children in the developing world. The cause and consequence of poor nutrition are multifaceted. Undernutrition has been associated with half of all deaths worldwide in children aged Malnutrition and the Consequences for Child Health (MAL-ED) Study, led by the Fogarty International Center of the National Institutes of Health and the Foundation for the National Institutes of Health, has been established at sites in 8 countries with historically high incidence of diarrheal disease and undernutrition. Central to the study is the hypothesis that enteropathogen infection contributes to undernutrition by causing intestinal inflammation and/or by altering intestinal barrier and absorptive function. It is further postulated that this leads to growth faltering and deficits in cognitive development. The effects of repeated enteric infection and undernutrition on the immune response to childhood vaccines is also being examined in the study. MAL-ED uses a prospective longitudinal design that offers a unique opportunity to directly address a complex system of exposures and health outcomes in the community-rather than the relatively rarer circumstances that lead to hospitalization-during the critical period of development of the first 2 years of life. Among the factors being evaluated are enteric infections (with or without diarrhea) and other illness indicators, micronutrient levels, diet, socioeconomic status, gut function, and the environment. MAL-ED aims to describe these factors, their interrelationships, and their overall impact on health outcomes in unprecedented detail, and to make individual, site-specific, and generalized recommendations regarding the nature and timing of possible interventions aimed at improving child health and development in these resource-poor settings. Published by Oxford University Press on

  15. Treatment Effects for Older Struggling Readers: An Application of Moderated Mediation.

    Roberts, Greg; Fletcher, Jack M; Stuebing, Karla K; Barth, Amy E; Vaughn, Sharon


    This study used multigroup structural equations to evaluate the possibility that a theory-driven, evidence-based, yearlong reading program for sixth-grade struggling readers moderates the interrelationships among elements of the simple model of reading (i.e., listening comprehension, word reading, and reading comprehension; Hoover & Gough, 1990). Our specific interest was in the relation of theory, program, and evaluation. Our motivating assumptions were that 1) a well-designed, theory-based program affects performance in predictable ways and that 2) treatment effects may be present even when group differences in posttest means are not robust. The analysis sample comprised 327 students, 113 in the business-as-usual condition and 214 in treatment. We pretested students in the fall of sixth grade and collected posttest data in the fall of seventh grade. There were 217 cases in the posttest sample, 47 comparison students and 170 treatment students at posttest. The findings support the possibility that treated sixth-grade students improved in response to an intensive, yearlong intervention, when conceptualizing change in terms of predictable interrelationships of important underlying skills, rather than in terms of group mean differences at posttest. Specifically, the results suggest that verbal knowledge is less proximal to the reading comprehension of students who have become proficient in the use of text processing and reading comprehension strategies.

  16. Soft Tissue Sarcoma Response to Two Cycles of Neoadjuvant Chemotherapy: A Multireader Analysis of MRI Findings and Agreement with RECIST Criteria and Change in SUVmax.

    Favinger, Jennifer L; Hippe, Daniel S; Davidson, Darin J; Elojeimy, Saeed; Roth, Eira S; Lindberg, Antoinette W; Ha, Alice S


    When soft tissue sarcomas are treated with neoadjuvant chemotherapy, the number of cycles of chemotherapy is usually dependent on the tumor's initial response. Popular methods to assess tumor response include Response Evaluation Criteria in Solid Tumors (RECIST) criteria, which rely solely on tumor size, and maximum standardized uptake value (SUVmax) reduction in positron emission tomography (PET), which requires an expensive and high radiation test. We hypothesized that contrast-enhanced magnetic resonance imaging (MRI) may offer a good alternative by providing additional information beyond tumor size. Following IRB approval, a retrospective review identified patients with soft tissue sarcomas who underwent both PET and MRI before and after two cycles of neoadjuvant chemotherapy. Five readers independently examined the MRI exams for: changes in size, T2 or T1 signal, necrosis and degree of enhancement. Readers then made a subjective binary assessment of tumor response to therapy. Each reader repeated the anonymized randomized reading at least 2 weeks apart. 18 F-FDG PET exams were interpreted by a nuclear medicine specialist. The maximum standardized uptake values (SUVmax) for pre and post-chemotherapy exams were compared. Intra- and inter-reader agreement was assessed using Cohen's kappa and Light's kappa, respectively. . Twenty cases were selected for this multireader study, of which 9 (45%) were responders and 11 were nonresponders by SUVmax. Using all MRI criteria, 43% were classified as responders based on MRI and 1.5% were classified as responders by RECIST criteria. Using PET as the reference, the sensitivity and the specificity of the MRI diagnosis for response using all findings were 50% and 63%, respectively. There was fair to moderate intrareader (kappa = 0.37) and inter-reader (kappa = 0.48) agreement for the MRI diagnosis of response. None of the individual MRI signal characteristics were significantly different between the PET responders and

  17. Stellar Archaeology -- Exploring the Universe with Metal-Poor Stars

    Frebel, Anna


    The abundance patterns of the most metal-poor stars in the Galactic halo and small dwarf galaxies provide us with a wealth of information about the early Universe. In particular, these old survivors allow us to study the nature of the first stars and supernovae, the relevant nucleosynthesis processes responsible for the formation and evolution of the elements, early star- and galaxy formation processes, as well as the assembly process of the stellar halo from dwarf galaxies a long time ago. T...

  18. Mongo Beti's The Poor Christ of Bomba


    Mar 28, 2016 ... discovered the Harlem Renaissance Movement or New Negro Movement ... Beti picks up as a subject for his satire in The Poor Christ of Bomba. ..... slave driver, and the indigenous man into an instrument of production” (6).

  19. Scoring sacroiliac joints by magnetic resonance imaging. A Multiple-reader reliability experiment

    Landewé, RB; Hermann, KG; van der Heijde, DM


    Magnetic resonance imaging (MRI) of the sacroiliac (SI) joints and the spine is increasingly important in the assessment of inflammatory activity and structural damage in clinical trials with patients with ankylosing spondylitis (AS). We investigated inter-reader reliability and sensitivity...... for 'depth' and 'intensity,' and the fifth method included the SPARCC slice with the maximum score. Inter-reader reliability was investigated by calculating intraclass correlation coefficients (ICC) for all readers together and for all possible reader pairs. Sensitivity to change was investigated...... values close to zero (no agreement) and highest observed values over 0.80 (excellent agreement). In general, agreement of status scores was somewhat better than agreement of change scores, and agreement of the comprehensive SPARCC scoring system was somewhat better than agreement of the more condensed...

  20. Hold the Applause!: Do Accelerated Reader (TM) and Electronic Bookshelf (TM) Send the Right Message?

    Carter, Betty


    Although the computerized reading management programs, Accelerated Reader and Electronic Bookshelf, increase library circulation and standardized test scores, they have drawbacks. Both programs devalue reading, diminish motivation, limit title choice, restrict materials selection and collection development, discourage independent selection of…