Phase resetting for a network of oscillators via phase response curve approach.
Efimov, D
2015-02-01
The problem of phase regulation for a population of oscillating systems is considered. The proposed control strategy is based on a phase response curve (PRC) model of an oscillator (the first-order reduced model obtained for linearized system and inputs with infinitesimal amplitude). It is proven that the control provides phase resetting for the original nonlinear system. Next, the problem of phase resetting for a network of oscillators is considered when applying a common control input. Performance of the obtained solutions is demonstrated via computer simulation for three different models of circadian/neural oscillators.
Cermak, Daniel; Holmgård, Christoffer
2015-01-01
Daniel Cermak-Sassenrath, Christoffer Holmgård. Russian Reset. Installation. HyperKult XXV: Shutdown, Lüneburg, FRG, Jul 9-11, 2015.......Daniel Cermak-Sassenrath, Christoffer Holmgård. Russian Reset. Installation. HyperKult XXV: Shutdown, Lüneburg, FRG, Jul 9-11, 2015....
An automatic (or semi-automatic) apparatus for the determination of melting curves
Smit, W.M.; Kateman, G.
1957-01-01
A description is given of an apparatus for the determination of heating curves by means of the “thin film” method The amount of substance used is about 500 rng The apparatus permits the automatic recording of heating curves with an accuracy of 0.001°C within a range of 0.2°C By simply resetting a re
Oct4 resetting by Aurkb-PP1 cell cycle axis determines the identity of mouse embryonic stem cells.
Shin, Jihoon; Youn, Hong-Duk
2016-10-01
In embryonic stem cells (ESCs), cell cycle regulation is deeply connected to pluripotency. Especially, core transcription factors (CTFs) which are essential to maintaining the pluripotency transcription programs should be reset during M/G1 transition. However, it remains unknown about how CTFs are governed during cell cycle progression. Here, we describe that the regulation of Oct4 by Aurora kinase b (Aurkb)/protein phosphatase 1 (PP1) axis during the cell cycle is important for resetting Oct4 to pluripotency and cell cycle related target genes in determining the identity of ESCs. Aurkb starts to phosphorylate Oct4(S229) at the onset of G2/M phase, inducing the dissociation of Oct4 from chromatin, whereas PP1 binds Oct4 and dephosphorylates Oct4(S229) during M/G1 transition, which resets Oct4-driven transcription for pluripotency and the cell cycle. Furthermore, Aurkb phosphormimetic and PP1 binding-deficient mutations in Oct4 disrupt the pluripotent cell cycle, lead to the loss of pluripotency in ESCs, and decrease the efficiency of somatic cell reprogramming. Based on our findings, we suggest that the cell cycle is directly linked to pluripotency programs in ESCs. [BMB Reports 2016; 49(10): 527-528].
Shin, Jihoon; Kim, Tae Wan; Kim, Hyunsoo; Kim, Hye Ji; Suh, Min Young; Lee, Sangho; Lee, Han-Teo; Kwak, Sojung; Lee, Sang-Eun; Lee, Jong-Hyuk; Jang, Hyonchol; Cho, Eun-Jung; Youn, Hong-Duk
2016-02-15
Pluripotency transcription programs by core transcription factors (CTFs) might be reset during M/G1 transition to maintain the pluripotency of embryonic stem cells (ESCs). However, little is known about how CTFs are governed during cell cycle progression. Here, we demonstrate that the regulation of Oct4 by Aurora kinase b (Aurkb)/protein phosphatase 1 (PP1) during the cell cycle is important for resetting Oct4 to pluripotency and cell cycle genes in determining the identity of ESCs. Aurkb phosphorylates Oct4(S229) during G2/M phase, leading to the dissociation of Oct4 from chromatin, whereas PP1 binds Oct4 and dephosphorylates Oct4(S229) during M/G1 transition, which resets Oct4-driven transcription for pluripotency and the cell cycle. Aurkb phosphor-mimetic and PP1 binding-deficient mutations in Oct4 alter the cell cycle, effect the loss of pluripotency in ESCs, and decrease the efficiency of somatic cell reprogramming. Our findings provide evidence that the cell cycle is linked directly to pluripotency programs in ESCs.
Baños, Alfonso
2012-01-01
Reset Control Systems addresses the analysis for reset control treating both its basic form which requires only that the state of the controller be reinitialized to zero (the reset action) each time the tracking error crosses zero (the reset condition), and some useful variations of the reset action (partial reset with fixed or variable reset percentage) and of the reset condition (fixed or variable reset band and anticipative reset). The issues regarding reset control – concepts and motivation; analysis tools; and the application of design methodologies to real-world examples – are given comprehensive coverage. The text opens with an historical perspective which moves from the seminal work of the Clegg integrator and Horowitz FORE to more recent approaches based on impulsive/hybrid control systems and explains the motivation for reset compensation. Preliminary material dealing with notation, basic definitions and results, and with the definition of the control problem under study is also included. The fo...
Accurate determination of characteristic relative permeability curves
Krause, Michael H.; Benson, Sally M.
2015-09-01
A recently developed technique to accurately characterize sub-core scale heterogeneity is applied to investigate the factors responsible for flowrate-dependent effective relative permeability curves measured on core samples in the laboratory. The dependency of laboratory measured relative permeability on flowrate has long been both supported and challenged by a number of investigators. Studies have shown that this apparent flowrate dependency is a result of both sub-core scale heterogeneity and outlet boundary effects. However this has only been demonstrated numerically for highly simplified models of porous media. In this paper, flowrate dependency of effective relative permeability is demonstrated using two rock cores, a Berea Sandstone and a heterogeneous sandstone from the Otway Basin Pilot Project in Australia. Numerical simulations of steady-state coreflooding experiments are conducted at a number of injection rates using a single set of input characteristic relative permeability curves. Effective relative permeability is then calculated from the simulation data using standard interpretation methods for calculating relative permeability from steady-state tests. Results show that simplified approaches may be used to determine flowrate-independent characteristic relative permeability provided flow rate is sufficiently high, and the core heterogeneity is relatively low. It is also shown that characteristic relative permeability can be determined at any typical flowrate, and even for geologically complex models, when using accurate three-dimensional models.
Hoogland, J.K.; Neumann, C.D.D.; Bloch, D.
2001-01-01
We give a simple algorithm to incorporate the effects of resets in convertible bond prices, without having to add an extra factor to take into account the value of the reset. Furthermore we show that the effect of a notice period, and additional make-whole features, can be treated in a straightforwa
Julgeolekupoliitiline reset / Andrei Hvostov
Hvostov, Andrei, 1963-
2009-01-01
Kesk- ja Ida-Euroopa poliitikute ja ühiskonnategelaste julgeolekupoliitiline avalik kiri Ameerika Ühendriikide administratsioonile. USA-Venemaa suhetes käsitsetakse viimasel ajal reset-nuppu. Autori hinnangul vajab ilmselt reset-nuppu ka Eesti julgeolekupoliitiline kogukond
Querry, R. G.; Smith, S. A.; Stromstad, M.; Ide, K.; Raven, P. B.; Secher, N. H.
2001-01-01
This investigation was designed to determine central command's role on carotid baroreflex (CBR) resetting during exercise. Nine volunteer subjects performed static and rhythmic handgrip exercise at 30 and 40% maximal voluntary contraction (MVC), respectively, before and after partial axillary neural blockade. Stimulus-response curves were developed using the neck pressure-neck suction technique and a rapid pulse train protocol (+40 to -80 Torr). Regional anesthesia resulted in a significant reduction in MVC. Heart rate (HR) and ratings of perceived exertion (RPE) were used as indexes of central command and were elevated during exercise at control force intensity after induced muscle weakness. The CBR function curves were reset vertically with a minimal lateral shift during control exercise and exhibited a further parallel resetting during exercise with neural blockade. The operating point was progressively reset to coincide with the centering point of the CBR curve. These data suggest that central command was a primary mechanism in the resetting of the CBR during exercise. However, it appeared that central command modulated the carotid-cardiac reflex proportionately more than the carotid-vasomotor reflex.
Methodology and apparatus for determining psychoacoustical threshold curves
2016-01-01
The present invention relates in a first aspect to a method of determining a psychoacoustical threshold curve by selectively varying a first parameter and a second parameter of an auditory stimulus signal applied to a test subject/listener. The methodology comprises steps of determining a two...
Determination of the human spine curve based on laser triangulation.
Poredoš, Primož; Čelan, Dušan; Možina, Janez; Jezeršek, Matija
2015-02-05
The main objective of the present method was to automatically obtain a spatial curve of the thoracic and lumbar spine based on a 3D shape measurement of a human torso with developed scoliosis. Manual determination of the spine curve, which was based on palpation of the thoracic and lumbar spinous processes, was found to be an appropriate way to validate the method. Therefore a new, noninvasive, optical 3D method for human torso evaluation in medical practice is introduced. Twenty-four patients with confirmed clinical diagnosis of scoliosis were scanned using a specially developed 3D laser profilometer. The measuring principle of the system is based on laser triangulation with one-laser-plane illumination. The measurement took approximately 10 seconds at 700 mm of the longitudinal translation along the back. The single point measurement accuracy was 0.1 mm. Computer analysis of the measured surface returned two 3D curves. The first curve was determined by manual marking (manual curve), and the second was determined by detecting surface curvature extremes (automatic curve). The manual and automatic curve comparison was given as the root mean square deviation (RMSD) for each patient. The intra-operator study involved assessing 20 successive measurements of the same person, and the inter-operator study involved assessing measurements from 8 operators. The results obtained for the 24 patients showed that the typical RMSD between the manual and automatic curve was 5.0 mm in the frontal plane and 1.0 mm in the sagittal plane, which is a good result compared with palpatory accuracy (9.8 mm). The intra-operator repeatability of the presented method in the frontal and sagittal planes was 0.45 mm and 0.06 mm, respectively. The inter-operator repeatability assessment shows that that the presented method is invariant to the operator of the computer program with the presented method. The main novelty of the presented paper is the development of a new, non-contact method
Flow Curve Determination for Non-Newtonian Fluids.
Tjahjadi, Mahari; Gupta, Santosh K.
1986-01-01
Describes an experimental program to examine flow curve determination for non-Newtonian fluids. Includes apparatus used (a modification of Walawender and Chen's set-up, but using a 50cc buret connected to a glass capillary through a Tygon tube), theoretical information, procedures, and typical results obtained. (JN)
Crack resistance curves determination of tube cladding material
Bertsch, J.; Hoffelner, W.
2006-06-01
Zirconium based alloys have been in use as fuel cladding material in light water reactors since many years. As claddings change their mechanical properties during service, it is essential for the assessment of mechanical integrity to provide parameters for potential rupture behaviour. Usually, fracture mechanics parameters like the fracture toughness KIC or, for high plastic strains, the J-integral based elastic-plastic fracture toughness JIC are employed. In claddings with a very small wall thickness the determination of toughness needs the extension of the J-concept beyond limits of standards. In the paper a new method based on the traditional J approach is presented. Crack resistance curves (J-R curves) were created for unirradiated thin walled Zircaloy-4 and aluminium cladding tube pieces at room temperature using the single sample method. The procedure of creating sharp fatigue starter cracks with respect to optical recording was optimized. It is shown that the chosen test method is appropriate for the determination of complete J-R curves including the values J0.2 (J at 0.2 mm crack length), Jm (J corresponding to the maximum load) and the slope of the curve.
Experimental And Theoretical Determination Of Forming Limit Curve
Adamus J.
2015-09-01
Full Text Available The paper presents a method for determining forming limit curves based on a combination of experiments with finite element analysis. In the experiment a set of 6 samples with different geometries underwent plastic deformation in stretch forming till the appearance of fracture. The heights of the stamped parts at fracture moment were measured. The sheet - metal forming process for each sample was numerically simulated using Finite Element Analysis (FEA. The values of the calculated plastic strains at the moment when the simulated cup reaches the height of the real cup at fracture initiation were marked on the FLC. FLCs for stainless steel sheets: ASM 5504, 5596 and 5599 have been determined. The resultant FLCs are then used in the numerical simulations of sheet - metal forming. A comparison between the strains in the numerically simulated drawn - parts and limit strains gives the information if the sheet - metal forming process was designed properly.
Leonhard eLücken
2013-05-01
Full Text Available Several brain diseases are characterized by abnormalneuronal synchronization. Desynchronization of abnormal neural synchronyis theoretically compelling because of the complex dynamical mechanismsinvolved. We here present a novel type of coordinated reset (CR stimulation.CR means to deliver phase resetting stimuli at different neuronalsub-populations sequentially, i.e. at times equidistantly distributedin a stimulation cycle. This uniform timing pattern seems to be intuitiveand actually applies to the neural network models used for the studyof CR so far. CR resets the population to an unstable cluster statefrom where it passes through a desynchronized transient, eventuallyresynchronizing if left unperturbed. In contrast, we show that theoptimal stimulation times are nonuniform. Using the model of weaklypulse-coupled neurons with phase response curves, we provide an approachthat enables to determine optimal stimulation timing patterns thatsubstantially maximize the desynchronized transient time followingthe application of CR stimulation. This approach includes an optimizationsearch for clusters in a low-dimensional pulse coupled map. As a consequence,model-specific non-uniformly spaced cluster states cause considerablylonger desynchronization transients. Intriguingly, such a desynchronizationboost with non-uniform CR stimulation can already be achieved by onlyslight modifications of the uniform CR timing pattern. Our resultssuggest that the non-uniformness of the stimulation times can be amedically valuable parameter in the calibration procedure for CR stimulation,where the latter has successfully been used in clinical and pre-clinicalstudies for the treatment of Parkinson's disease and tinnitus.
Crack resistance curve determination of zircaloy-4 cladding
Bertsch, J.; Alam, A.; Zubler, R
2009-03-15
Fracture mechanics properties of fuel claddings are of relevance with respect to fuel rod integrity. The integrity of a fuel rod, in turn, is important for the fuel performance, for the safe handling of fuel rods, for the prevention of leakages and subsequent dissemination of fuel, for the avoidance of unnecessary dose rates, and for safe operation. Different factors can strongly deteriorate the mechanical fuel rod properties: irradiation damage, thermo-mechanical impact, corrosion or hydrogen uptake. To investigate the mechanical properties of fuel rod claddings which are used in Swiss nuclear power plants, PSI has initiated a program for mechanical testing. A major issue was the interaction between specific loading devices and the tested cladding tube, e.g. in the form of bending or friction. Particular for Zircaloy is the hexagonal closed packed structure of the zirconium crystallographic lattice. This structure implies plastic deformation mechanisms with specific, preferred orientations. Further, the manufacturing procedure of Zircaloy claddings induces a specific texture which plays a salient role with respect to the embrittlement by irradiation or integration of hydrogen in the form of hydrides. Both, the induced microstructure as well as the plastic deformation behaviour play a role for the mechanical properties. At PSI, in a first step inactive thin walled Zircaloy tubes and, for comparison reasons, plates were tested. The validity of the mechanical testing of the non standard tube and plate geometries had to be verified. The used Zircaloy-4 cladding tube sections and small plates of the same wall thickness have been notched, fatigue pre-cracked and tensile tested to evaluate the fracture toughness properties at room temperature, 300 {sup o}C and 350 {sup o}C. The crack propagation has been determined optically. The test results of the plates have been further used to validate FEM calculations. For each sample a complete crack resistance (J-R) curve could
IT department
2011-01-01
Forgotten your password? Throughout the year, one of the most common requests to the Service Desk concerns password resets. This is especially the case now that we are at the end of the holiday season and many of us return after a long break. Currently, the only way to have your password reset is to call the Service Desk during the week and within the service hours (07:30 to 18:30). Not anymore! The IT department is putting up a new service that will allow you to reset the password of your primary CERN account by yourself. Note, that you will still be able to request a password reset by calling the Service Desk as usual and that you will still have to do this if your account has been blocked for any reason. However, the new service provides you with more flexibility and convenience when your memory has failed you. In order to take advantage of this new service, you must: • Have a valid, active account • Register in advance an external...
MATHEMATICAL METHODS TO DETERMINE THE INTERSECTION CURVES OF THE CYLINDERS
POPA Carmen
2010-07-01
Full Text Available The aim of this paper is to establish the intersection curves between cylinders, by using the Mathematica program. This thing can be obtained by introducing the curves equations, which are inferred, in Mathematica program. This paper take into discussion three right cylinders and another inclined to 45 degrees. The intersection curves can also be obtained by using the classical methods of the descriptive geometry.
Reset stabilisation of positive linear systems
Zhao, Xudong; Yin, Yunfei; Shen, Jun
2016-09-01
In this paper, the problems of reset stabilisation for positive linear systems (PLSs) are investigated. Some properties relating to reset control of PLSs are first revealed. It is shown that these properties are different from the corresponding ones of general linear systems. Second, a class of periodic reset scheme is designed to exponentially stabilise an unstable PLS with a prescribed decay rate. Then, for a given PLS with reset control, some discussions on the upper bound of its decay rate are presented. Meanwhile, the reset stabilisation for PLSs in a special case is probed as well. Finally, two numerical examples are used to demonstrate the correctness and effectiveness of the obtained theoretical results.
A Neophyte's Determination of EY Ceph Curves and Orbital Constants
Menke, J. L.
2002-05-01
Using amateur level equipment, and with a beginner's knowledge of photometry, I have built the light curve for the eclipsing variable EY Cephei (subject suggested by Claud Lacy). This 10mag star has two 0.6mag eclipses per cycle, with a period of 7.97 days. The good observing news is that it is circumpolar (so easily visible), the bad news is that if the eclipses are not visible at night at your location (or if you miss them), you have to wait 6-8 months before they return. Combine this with only three days notice to start the campaign, no experience in precision photometry, and limited (but good) equipment, the amazing thing is that I achieved success in the first week (then the weather deteriorated...). I will present intensity curve results to date, discuss how I got to them, and provide the results of a preliminary calculation of the system parameters (orbits, sizes, etc).
HADA TEODOR
2015-03-01
Full Text Available This article is organized in four parts. The first part presents theoretical aspects on determining the efficiency curve and the steps to be taken on this. The second part begins with a case study presenting the methods of determining the efficiency curve of a stock portfolio, in the case of several entities listed on the Bucharest Stock Exchange. The third part shows how useful Microsoft Excel is to determine the Markovitz efficiency curve of a stock portfolio. On completion of this work, we present the findings on the methods of determining the Markovitz efficiency curve using Microsoft Excel, and their related interpretations.
Determination of error measurement by means of the basic magnetization curve
Lankin, M. V.; Lankin, A. M.
2016-04-01
The article describes the implementation of the methodology for determining the error search by means of the basic magnetization curve of electric cutting machines. The basic magnetization curve of the integrated operation of the electric characteristic allows one to define a fault type. In the process of measurement the definition of error calculation of the basic magnetization curve plays a major role as in accuracies of a particular characteristic can have a deleterious effect.
Kim, Sungjun; Park, Byung-Gook
2017-01-01
In this letter, we compare three different types of reset switching behavior in a bipolar resistive random-access memory (RRAM) system that is housed in a Ni/Si3N4/Si structure. The abrupt, step-like gradual and continuous gradual reset transitions are largely determined by the low-resistance state (LRS). For abrupt reset switching, the large conducting path shows ohmic behavior or has a weak nonlinear current-voltage (I-V) characteristics in the LRS. For gradual switching, including both the step-like and continuous reset types, trap-assisted direct tunneling is dominant in the low-voltage regime, while trap-assisted Fowler-Nordheim tunneling is dominant in the high-voltage regime, thus causing nonlinear I-V characteristics. More importantly, we evaluate the multi-level capabilities of the two different gradual switching types, including both step-like and continuous reset behavior, using identical and incremental voltage conditions. Finer control of the conductance level with good uniformity is achieved in continuous gradual reset switching when compared to that in step-like gradual reset switching. For continuous reset switching, a single conducting path, which initially has a tunneling gap, gradually responds to pulses with even and identical amplitudes, while for step-like reset switching, the multiple conducting paths only respond to incremental pulses to obtain effective multi-level states.
Determination of J-resistance curves of nuclear structure materials by iteration method
Byun, Thak Sang; Lee, Bong Sang; Yoon, Ji Hyun; Kuk, Il Hiun; Hong, Jun Hwa [KAERI, Taejon (Korea, Republic of)
1998-05-01
An iteration method has been developed for determining crack growth and fracture resistance curve (J-R curve) from the load versus load-line displacement record only. In this method, the hardening curve, the load versus displacement curve at a given crack length, is assumed to be a power-law function, where the exponent varies with the crack length. The exponent is determined by an interative calculation method with the assumption that the exponent varies linearly with the load-line displacement. The proposed method was applied to the static J-R tests using compact tension (CT) specimens, a three-point bend (TPB) specimen, and a cracked round bar (CRB) specimen as well as it was applied to the quasi-dynamic J-R tests using CT specimens. The J-R curves determined by the proposed method were compared with those obtained by the conventional testing methodologies. The results showed that the J-R curves could be determined directly by the proposed iteration method with sufficient accuracy in the specimens from SA508, SA533, and SA516 pressure vessel steels and SA312 Type 347 stainless steel.
Sharma, B. Arunkumar [Department of Radiotherapy, RIMS, Lamphel, Imphal 795004, Manipur (India)], E-mail: arunsb2000@yahoo.co.uk; Singh, A. Nabachandra [Department of Physics, Thoubal College, Thoubal 795138, Manipur (India); Singh, S. Nabadwip [Department of Physics, Kumbi College, Kumbi 795133, Manipur (India); Singh, O. Binoykumar [Department of Physics, Y.K. College, Wangjing 795148, Manipur (India)
2009-01-15
Kinetic parameters of glow peaks (as many as 14 in the range of 75-575 deg. C) of colorless microcline have been successfully achieved to a high degree of certainty by resorting to computerized glow curve deconvolution (CGCD) in the framework of kinetics formalism. The second derivative plot of the experimental glow curve is used to locate the hidden glow peaks. The criteria to accept the goodness of fit between the experimental glow curve and the numerically generated best fit curve is judged by statistical test namely, {chi}{sup 2}-test. As a cross check, figure of merit (FOM) is also evaluated. The kinetic parameters of the higher temperature trap electrons of colorless microcline are determined by using lower heating rates.
Sex determination in beef by melting curve analysis of PCR amplicons from the amelogenin locus.
Ballin, Nicolai Z; Madsen, Knud G
2007-11-01
Sex determination of beef is important to meet the rules of the Commission Regulation (EC) 765/2002 that qualify for export refunds. A SYBR Green sex identification assay based on melting curve analysis of PCR amplicons from the amelogenin locus (AMELX and AMELY) was developed. The PCR amplicons of 130/130 and 130/67 base pairs produced from female and male beef, respectively, are easily distinguished by both melting curve analysis and gel electrophoresis. Results from the melting curve analysis of amplicons are ready in less than three minutes, and requires no additional work in addition to the PCR setup. Applicability of the sex determination assay was studied by analysis of 12 unknown beef samples and the results were compared to an accredited method based on gel electrophoresis. In addition, six different cattle breeds were examined. All test results were correct in respect to sex.
Comparison Of Selected Pedotransfer Functions For The Determination Of Soil Water Retention Curves
Kupec, Michal; Stradiot, Peter; Rehák, Štefan
2015-09-01
Soil water retention curves were measured using a sandbox and the pressure plate extractor method on undisturbed soil samples from the Borská Lowland. The basic soil properties (e.g. soil texture, dry bulk density) of the samples were determined. The soil water retention curve was described using the van Genuchten model (Van Genuchten, 1980). The parameters of the model were obtained using the RETC program (Van Genuchten et al., 1991). For the determination of the soil water retention curve parameters, two pedotransfer functions (PTF) were also used that were derived for this area by Skalová (2003) and the Rosetta computer program (Schaap et al., 2001). The performance of the PTFs was characterized using the mean difference and root mean square error.
Comparison Of Selected Pedotransfer Functions For The Determination Of Soil Water Retention Curves
Kupec Michal
2015-09-01
Full Text Available Soil water retention curves were measured using a sandbox and the pressure plate extractor method on undisturbed soil samples from the Borská Lowland. The basic soil properties (e.g. soil texture, dry bulk density of the samples were determined. The soil water retention curve was described using the van Genuchten model (Van Genuchten, 1980. The parameters of the model were obtained using the RETC program (Van Genuchten et al., 1991. For the determination of the soil water retention curve parameters, two pedotransfer functions (PTF were also used that were derived for this area by Skalová (2003 and the Rosetta computer program (Schaap et al., 2001. The performance of the PTFs was characterized using the mean difference and root mean square error.
Cantrell, Andrew Glenn
We consider two types of anomalous observations which have arisen from efforts to measure dynamical masses of X-ray binary stars: (1) Radial velocity curves which seemingly show the primary and the secondary out of antiphase in most systems, and (2) The observation of double-waved light curves which deviate significantly from the ellipsoidal modulations expected for a Roche lobe filling star. We consider both problems with the joint goals of understanding the physical origins of the anomalous observations, and using this understanding to allow robust dynamical determinations of mass in X-ray binary systems. In our analysis of phase-shifted radial velocity curves, we discuss a comprehensive sample of X-ray binaries with published phase-shifted radial velocity curves. We show that the most commonly adopted explanation for phase shifts is contradicted by many observations, and consider instead a generalized form of a model proposed by Smak in 1970. We show that this model is well supported by a range of observations, including some systems which had previously been considered anomalous. We lay the groundwork for the derivation of mass ratios based on our explanation for phase shifts, and we discuss the work necessary to produce more detailed physical models of the phase shift. In our analysis of non-ellipsoidal light curves, we focus on the very well-studied system A0620-00. We present new VIH SMARTS photometry spanning 1999-2007, and supplement this with a comprehensive collection of archival data obtained since 1981. We show that A0620-00 undergoes optical state changes within X-ray quiescence and argue that not all quiescent data should be used for determinations of the inclination. We identify twelve light curves which may reliably be used for determining the inclination. We show that the accretion disk contributes significantly to all twelve curves and is the dominant source of nonellipsoidal variations. We derive the disk fraction for each of the twelve curves
Božidar V Krstić
2010-01-01
Full Text Available Analysis of output quality of power transmitters is possible in position when characteristics are determined earlier. This is the reason why we focused on determination of these characteristics for a concrete power hydro-transmitter. This means that the investigation task primarily consisted of determination of functional characteristics, defining of the sliding curves and temperature regimes of a concrete hydrodynamic clutch. Results of velocity and pressure field investigations in the working space of this clutch, obtained by use of the same test setup, are the basis for determination and analysis of the functional characteristics, sliding curves and temperature regimes. In this work we also analyzed function of the hydrodynamic transmitter in assembly with an internal combustion engine, as well as a process of acceleration and deceleration of a vehicle with this assembly in it.
无
2007-01-01
The hardening curve for sheet metal can be determined from the load-displacement curve of tensilespecimen with rectangular cross-section. Therefore, uniaxial compression test on cylinder specimen made from laminated sample is put forward. Considering the influence of anisotropy on hardening properties and the stress state in popular forming process, plane strain compression test on cubic specimen made from laminated sample was advanced. Results show that the deformation range of hardening curves obtained from the presented methods is wide, which meets the need for the application in sheet metal forming processes. In view of the characteristics of methods presented in the paper and the stress strain state of various forming processes, the adaptability of the two methods presented in this paper is given.
Castex, M. C.; Morlais, M.; Spiegelmann, F.; Malrieu, J. P.
1981-11-01
Accurate potential curves have been determined for the (3p54s)Ar*+(1S0) Ar excimer, with extended basis sets, large CI and the Cohen-Schneider spin-orbit coupling scheme. Using the synchrotron radiation, measurements of the quantitative absorption temperature dependence of the wings of the 3P1 and 1P1 lines have been made and parts of the potential curves have been derived through the quasistatic treatment. The theoretical work shows that the complex and detailed shapes of the curves result from the action of various physical phenomena (electronic correlation, van der Waals dispersion forces, R-3 resonance interaction, and spin-orbit coupling); however a sufficiently accurate calculation and analysis allows a state by state comparison with absorption and emission experimental results and an attempt to gather and clarify the present knowledge.
A passivity-based approach to reset control systems stability
Carrasco, Joaquín; Baños, Alfonso; Schaft, Arjan van der
The stability of reset control systems has been mainly studied for the feedback interconnection of reset compensators with linear time-invariant systems. This work gives a stability analysis of reset compensators in feedback interconnection with passive nonlinear systems. The results are based on
Vector Bundles with a Fixed Determinant on an Irreducible Nodal Curve
Usha N Bhosle
2005-11-01
Let be the moduli space of generalized parabolic bundles (GPBs) of rank and degree on a smooth curve . Let $M_{\\overline{L}}$ be the closure of its subset consisting of GPBs with fixed determinant $\\overline{L}$. We define a moduli functor for which $M_{\\overline{L}}$ is the coarse moduli scheme. Using the correspondence between GPBs on and torsion-free sheaves on a nodal curve of which is a desingularization, we show that $M_{\\overline{L}}$ can be regarded as the compactified moduli scheme of vector bundles on with fixed determinant. We get a natural scheme structure on the closure of the subset consisting of torsion-free sheaves with a fixed determinant in the moduli space of torsion-free sheaves on . The relation to Seshadri–Nagaraj conjecture is studied.
On robustness of phase resetting to cell division under entrainment.
Ahmed, Hafiz; Ushirobira, Rosane; Efimov, Denis
2015-12-21
The problem of phase synchronization for a population of genetic oscillators (circadian clocks, synthetic oscillators, etc.) is considered in this paper, taking into account a cell division process and a common entrainment input in the population. The proposed analysis approach is based on the Phase Response Curve (PRC) model of an oscillator (the first order reduced model obtained for the linearized system and inputs with infinitesimal amplitude). The occurrence of cell division introduces state resetting in the model, placing it in the class of hybrid systems. It is shown that without common entraining input in all oscillators, the cell division acts as a disturbance causing phase drift, while the presence of entrainment guarantees boundedness of synchronization phase errors in the population. The performance of the obtained solutions is demonstrated via computer experiments for two different models of circadian/genetic oscillators (Neurospora׳s circadian oscillation model and the repressilator).
ROC-curve approach for determining the detection limit of a field chemical sensor.
Fraga, Carlos G; Melville, Angela M; Wright, Bob W
2007-03-01
The detection limit of a field chemical sensor under realistic operating conditions is determined by receiver operator characteristic (ROC) curves. The chemical sensor is an ion mobility spectrometry (IMS) device used to detect a chemical marker in diesel fuel. The detection limit is the lowest concentration of the marker in diesel fuel that obtains the desired true-positive probability (TPP) and false-positive probability (FPP). A TPP of 0.90 and a FPP of 0.10 were selected as acceptable levels for the field sensor in this study. The detection limit under realistic operating conditions is found to be between 2 to 4 ppm (w/w). The upper value is the detection limit under challenging conditions. The ROC-based detection limit is very reliable because it is determined from multiple and repetitive sensor analyses under realistic circumstances. ROC curves also clearly illustrate and gauge the effects data preprocessing and sampling environments have on the sensor's detection limit.
Determination of p-y Curves for Bucket Foundations in Sand Using Finite Element Modeling
Knudsen, Bjørn S.; Østergaard, Martin Underlin; Ibsen, Lars Bo
, the suction bucket has a much smaller ratio between length and diameter, and the suction buckets will thus act more as a rigid object during rotation in the soil. To improve the design of suction buckets through analytical methods, the soil pressure needs to be calculated more precisely since currently...... available py curves, linking displacement and soil pressure, are based on more slender cylindrical structures. Using finite element methods, the py curves for suction buckets will be determined as a function of the internal angle of friction of the soil, the diameter and the skirt length...... of the suction buckets, which can in turn be applied in determination of soil pressures for analytical design methods of suction bucket foundations....
The Complexity of Finding Reset Words in Finite Automata
Olschewski, Jörg; Ummels, Michael
We study several problems related to finding reset words in deterministic finite automata. In particular, we establish that the problem of deciding whether a shortest reset word has length k is complete for the complexity class DP. This result answers a question posed by Volkov. For the search problems of finding a shortest reset word and the length of a shortest reset word, we establish membership in the complexity classes FPNP and FPNP[log], respectively. Moreover, we show that both these problems are hard for FPNP[log]. Finally, we observe that computing a reset word of a given length is FNP-complete.
Wave Pipelining Using Self Reset Logic
Miguel E. Litvin
2008-01-01
Full Text Available This study presents a novel design approach combining wave pipelining and self reset logic, which provides an elegant solution at high-speed data throughput with significant savings in power and area as compared with other dynamic CMOS logic implementations. To overcome some limitations in SRL art, we employ a new SRL family, namely, dual-rail self reset logic with input disable (DRSRL-ID. These gates depict fairly constant timing parameters, specially the width of the output pulse, for varying fan-out and logic depth, helping accommodate process, supply voltage, and temperature variations (PVT. These properties simplify the implementation of wave pipelined circuits. General timing analysis is provided and compared with previous implementations. Results of circuit implementation are presented together with conclusions and future work.
Desynchronizing Electrical and Sensory Coordinated Reset Neuromodulation
Oleksandr V. Popovych
2012-03-01
Full Text Available Coordinated reset (CR stimulation is a desynchronizing stimulation technique based on timely coordinated phase resets of sub-populations of a synchronized neuronal ensemble. It has initially been computationally developed for electrical deep brain stimulation (DBS,to enable an effective desynchronization and unlearning of pathological synchrony and connectivity (anti-kindling. Here we computationally show for ensembles of spiking and bursting model neurons interacting via excitatory and inhibitory adaptive synapses that a phase reset of neuronal populations as well as a desynchronization and an anti-kindling can robustly be achieved by direct electrical stimulation or indirect (synaptically-mediated excitatory and inhibitory stimulation.Our findings are relevant for DBS as well as for sensory stimulation in neurological disorders characterized by pathological neuronalsynchrony. Based on the obtained results, we may expect that the local effects in the vicinity of a depth electrode (realized by direct stimulation of the neurons' somata or stimulation of axon terminals and the non-local CR effects (realized by stimulation of excitatory or inhibitory efferent fibers of deep brain CR neuromodulation may be similar or even identical. Furthermore, ourresults indicate that an effective desynchronization and anti-kindlingcan even be achieved by non-invasive, sensory CR neuromodulation. We discuss the concept of sensory CR neuromodulation in the context of neurological disorders.
Zirconium determination by cooling curve analysis during the pyroprocessing of used nuclear fuel
Westphal, B.R., E-mail: brian.westphal@inl.gov; Price, J.C.; Bateman, K.J.; Marsden, K.C.
2015-02-15
An alternative method to sampling and chemical analyses has been developed to monitor the concentration of zirconium in real-time during the casting of uranium products from the pyroprocessing of used nuclear fuel. The method utilizes the solidification characteristics of the uranium products to determine zirconium levels based on standard cooling curve analyses and established binary phase diagram data. Numerous uranium products have been analyzed for their zirconium content and compared against measured zirconium data. From this data, the following equation was derived for the zirconium content of uranium products: Zr=0.14M+131.56-12.63(348.65-0.16LT){sup 1/2} where M is the mass (kg) of the ingot and LT is the liquidus temperature (K) found by cooling curve analyses. Based on this equation, a reasonable fit of calculated to measured zirconium content was established considering the errors in the system.
Comparison of Frontal Analysis and Elution-Curve Method for Determining Adsorption Isotherms
Ju-Weon; LEE; Kyung; Ho; ROW
2002-01-01
Adsorption isotherm is the most fundamental information related to chromatography.To calculate the parameters of Langmuir adsorption isotherm of thymidine,fronal analysis(FA)and lution-curve method(ECM)were adopted in reversed-phase high performance liguid chromatography(RP-HPLC).In FA,tha concentration of stationary phase was measured from the elution curves and the isotherm was determined by regression analysis,while the parameters by ECM were obtained by parameter optimization.The adsorption isotherms of thymidine from the two methods were very similar.The superiority of ECM over FA was that the consumption of sample was less and only one or two in jections of sample were required.
Han, Fang; Wang, Zhijie; Fan, Hong
2017-01-01
This paper proposed a new method to determine the neuronal tuning curves for maximum information efficiency by computing the optimum firing rate distribution. Firstly, we proposed a general definition for the information efficiency, which is relevant to mutual information and neuronal energy consumption. The energy consumption is composed of two parts: neuronal basic energy consumption and neuronal spike emission energy consumption. A parameter to model the relative importance of energy consumption is introduced in the definition of the information efficiency. Then, we designed a combination of exponential functions to describe the optimum firing rate distribution based on the analysis of the dependency of the mutual information and the energy consumption on the shape of the functions of the firing rate distributions. Furthermore, we developed a rapid algorithm to search the parameter values of the optimum firing rate distribution function. Finally, we found with the rapid algorithm that a combination of two different exponential functions with two free parameters can describe the optimum firing rate distribution accurately. We also found that if the energy consumption is relatively unimportant (important) compared to the mutual information or the neuronal basic energy consumption is relatively large (small), the curve of the optimum firing rate distribution will be relatively flat (steep), and the corresponding optimum tuning curve exhibits a form of sigmoid if the stimuli distribution is normal. PMID:28270760
Chiu Liu, PhD, PE, PTOE
2013-06-01
Full Text Available The sight distance (SD on a three-dimensional (3-d compound curve has been studied recently in the absence of obstacles at road sides. Often, physical barriers are installed at road sides or in a roadway median for reducing potential collision severities; these rigid, semi-rigid, or even temporary cushion-type barriers can limit or reduce the driver's sight distance, depending on their horizontal offset distances away from the nearest edge of traveled way (ETW. The closer a barrier to the ETW is, the shorter the driver's sight distance would be. Since most barriers are constructed to prevent running-off road or crossing-median collisions, it is crucial to check whether the installation would reduce the driver's sight distance and potentially cause other traffic collisions such as rear-end or side swipe collisions. In this paper, an exact analytic framework is formulated with derived equations the first time to calculate the sight distance on a 3-d compound curve in the presence of a median barrier, a roadside barrier, or a temporary cushion or barrier used for construction or other maintenance purposes. This framework provides an engineer a handy tool to examine the possible change of SD in the presence of a barrier and choose the required horizontal offset/clearance of a barrier from the nearest traveled way edge to meet certain design criteria or standards. This critical offset distance determined using this framework not only reinforces the importance of having roadside clearance recovery zones on highways but also provides a method to determine its horizontal clearance from a different standpoint. This analytic framework can easily be programmed into an Excel spreadsheet to evaluate the design of a physical barrier and its potential influence on sight distance along a 3-d compound horizontal and vertical curve. Transportation engineers or practitioners may find this design tool handy and useful once the programmed spreadsheet is saved in a
Determination of critical nitrogen dilution curve based on stem dry matter in rice.
Syed Tahir Ata-Ul-Karim
Full Text Available Plant analysis is a very promising diagnostic tool for assessment of crop nitrogen (N requirements in perspectives of cost effective and environment friendly agriculture. Diagnosing N nutritional status of rice crop through plant analysis will give insights into optimizing N requirements of future crops. The present study was aimed to develop a new methodology for determining the critical nitrogen (Nc dilution curve based on stem dry matter (SDM and to assess its suitability to estimate the level of N nutrition for rice (Oryza sativa L. in east China. Three field experiments with varied N rates (0-360 kg N ha(-1 using three Japonica rice hybrids, Lingxiangyou-18, Wuxiangjing-14 and Wuyunjing were conducted in Jiangsu province of east China. SDM and stem N concentration (SNC were determined during vegetative stage for growth analysis. A Nc dilution curve based on SDM was described by the equation (Nc = 2.17W(-0.27 with W being SDM in t ha(-1, when SDM ranged from 0.88 to 7.94 t ha(-1. However, for SDM < 0.88 t ha(-1, the constant critical value Nc = 1.76% SDM was applied. The curve was dually validated for N-limiting and non-N-limiting growth conditions. The N nutrition index (NNI and accumulated N deficit (Nand of stem ranged from 0.57 to 1.06 and 51.1 to -7.07 kg N ha(-1, respectively, during key growth stages under varied N rates in 2010 and 2011. The values of ΔN derived from either NNI or Nand could be used as references for N dressing management during rice growth. Our results demonstrated that the present curve well differentiated the conditions of limiting and non-limiting N nutrition in rice crop. The SDM based Nc dilution curve can be adopted as an alternate and novel approach for evaluating plant N status to support N fertilization decision during the vegetative growth of Japonica rice in east China.
Zirconium determination by cooling curve analysis during the pyroprocessing of used nuclear fuel
Westphal, B. R.; Price, J. C.; Bateman, K. J.; Marsden, K. C.
2015-02-01
An alternative method to sampling and chemical analyses has been developed to monitor the concentration of zirconium in real-time during the casting of uranium products from the pyroprocessing of used nuclear fuel. The method utilizes the solidification characteristics of the uranium products to determine zirconium levels based on standard cooling curve analyses and established binary phase diagram data. Numerous uranium products have been analyzed for their zirconium content and compared against measured zirconium data. From this data, the following equation was derived for the zirconium content of uranium products:
Change in the CERN account password reset procedure
IT Department
2008-01-01
Since 19 August 2008, the security of the CERN account password reset procedure has been strengthened. As a result, users asking to have their password reset by the Computing Helpdesk will be asked to provide some personal information prior to resetting their CERN account password. Please note that all relevant information about CERN accounts and passwords can be found at http://cern.ch/it-dep/AccountsandpasswordsatCERN.htm Thank you in advance for your cooperation. IT Department
Change in the CERN account password reset procedure
IT Department
2008-01-01
From Since 19 August 19th 2008, the security of the CERN account password reset procedure has been strengthened. As a result, users requesting to have their password reset by the Computing Helpdesk will be asked to provide some private personal information prior to resetting their CERN account password. Please note that all relevant information about the CERN account and password can be found at http://cern.ch/it-dep/AccountsandpasswordsatCERN.htm Thank you in advance for your cooperation. IT Department
Defense Logistics: Marine Corps and Army Reset Liability Estimates
2015-06-22
reset the item will likely equal the historical average spent to repair the item. 12Unit repair cost refers to the amount of funding to reset a...equipment reset amounting to more than $700 million and that in the event of a crisis the Army would deploy units at a significantly lower readiness level.6...Deputy Assistant Secretary of the Army for Budget. Finally, we interviewed officials from the Office of the Secretary of Defense, Office of Cost
Determination of Lamb wave dispersion curves by means of Fourier transform
Hora P.
2012-06-01
Full Text Available This work reports on methods for determination of Lamb wave dispersion curves by means of Fourier transform (FT. Propagating Lamb waves are sinusoidal in both the frequency domain and the spatial domain. Therefore, the temporal FT may be carried out to go from the time to the frequency domain, and then the spatial FT may be carried out to go to the frequency–wave-number domain, where the amplitudes and the wave-numbers of individual modes may be measured. The result of this transform will be a 2D array of amplitudes at discrete frequencies and wave-numbers. Other method of determination of dispersion curves is based on the solution of FEM task in frequency domain. The frequency spectrum of a time-dependent excitation is defined using FT. Since a small number of frequencies are sufficient to achieve a correct representation of a wide variety of temporal excitations, this approach considerably speeds up the computation by avoiding the temporal FT and by decreasing the number of calculation steps.
ASTER/AVHRR Data Hybridization to determine Pyroclastic Flow cooling curves
Reath, K. A.; Wright, R.; Ramsey, M. S.
2014-12-01
Shiveluch Volcano (Kamchatka, Russia) has been in a consistent state of eruption for the past 15 years. During this period different eruption styles have been documented including: sub-plinian events, dome growth and collapse, and subsequent debris flow deposits. For example, on June 25-26, 2009 a pyroclastic debris flow was emplaced and the eruption onset that produced it was recorded by a series of seismic events spanning several hours. However, due to cloud cover, visual confirmation of the exact emplacement time was obscured. Orbital remote sensing was able to image the deposit repeatedly over the subsequent months. ASTER is a high spatial resolution (90m), low temporal resolution (2 - 4 days at the poles, 16 days at the equator) thermal infrared (TIR) sensor on the NASA Terra satellite. AVHRR is a high temporal resolution (minutes to several hours), low spatial resolution (1km) spaceborne TIR sensor on a series of NOAA satellites. Combined, these sensors provide a unique opportunity to fuse high-spatial and high-temporal resolution data to better observe changes on the surface of the deposit over time. For example, ASTER data were used to determine the flow area and to provide several data points for average temperature while AVHRR data were used to increase the amount of data points. Through this method an accurate average cooling rate over a three month period was determined. This cooling curve was then examined to derive several features about the deposit that were previously unknown. The time of emplacement and period of time needed for negligible thermal output were first determined by extrapolating the cooling curve in time. The total amount of heat output and total flow volume of the deposit were also calculated. This volume was then compared to the volume of the dome to calculate the percentage of collapse. This method can be repeated for other flow deposits to determine if there is a consistent correlation between the dome growth rate, the average
Beare, R. A.
2008-01-01
Professional astronomers use specialized software not normally available to students to determine the rotation periods of asteroids from fragmented light curve data. This paper describes a simple yet accurate method based on Microsoft Excel[R] that enables students to find periods in asteroid light curve and other discontinuous time series data of…
Beare, R. A.
2008-01-01
Professional astronomers use specialized software not normally available to students to determine the rotation periods of asteroids from fragmented light curve data. This paper describes a simple yet accurate method based on Microsoft Excel[R] that enables students to find periods in asteroid light curve and other discontinuous time series data of…
Yoshida,Akira
1986-02-01
Full Text Available To determine the characteristic curve of the radiographic screen/film systems in a short focal spot-film distance, the inverse square sensitometric method was modified by changing the radiation intensity with two kinds of filters. The characteristic curves obtained in the two exposure series with these two kinds of filters were overlapped to obtain a complete one. The characteristic curve thus obtained was almost the same as the one obtained by the original inverse square sensitometric method. The accuracy of the characteristic curves obtained by the modified method was well-reflected in the clinical radiographs.
CURRENT-VOLTAGE CURVES FOR TREATING EFFLUENT CONTAINING HEDP: DETERMINATION OF THE LIMITING CURRENT
T. Scarazzato
2015-12-01
Full Text Available Abstract Membrane separation techniques have been explored for treating industrial effluents to allow water reuse and component recovery. In an electrodialysis system, concentration polarization causes undesirable alterations in the ionic transportation mechanism. The graphic construction of the current voltage curve is proposed for establishing the value of the limiting current density applied to the cell. The aim of this work was to determine the limiting current density in an electrodialysis bench stack, the function of which was the treatment of an electroplating effluent containing HEDP. For this, a system with five compartments was used with a working solution simulating the rinse waters of HEDP-based baths. The results demonstrated correlation between the regions defined by theory and the experimental data.
On the Determination of Transiting Planet Properties from Light and Radial Velocity Curves
Southworth, John
2017-02-01
A recent publication has suggested a method to determine the masses and radii of the components of an eclipsing system using only a light curve and radial velocities of one component. If true, this would have immediate impact in expediting the study of transiting extrasolar planet and brown dwarf systems. The method is intended for situations where the mass ratio is significantly different from zero, but implicitly also requires the assumption that the mass ratio is negligible. We investigate both cases, finding that when the mass ratio is significant the method is mathematically identical to existing approaches, and when the mass ratio is negligible the equations become undefined. We therefore conclude that the method cannot be used to measure the physical properties of such systems from observations alone.
Using commercial simulators for determining flash distillation curves for petroleum fractions
Eleonora Erdmann
2010-04-01
Full Text Available This work describes a new method for estimating the equilibrium flash vaporisation (EFV distillation curve for petro-leum fractions by using commercial simulators. A commercial simulator was used for implementing a stationary mo-del for flash distillation; this model was adjusted by using a distillation curve obtained from standard laboratory ana-lytical assays. Such curve can be one of many types (eg ASTM D86, D1160 or D2887 and involves an experimental procedure simpler than that required for obtaining an EFV curve. Any commercial simulator able to model petroleum can be used for the simulation (HYSYS and CHEMCAD simulators were used here. Several types of petroleum and fractions were experimentally analysed for evaluating the proposed method; this data was then put into a process si-mulator (according to the proposed method to estimate the corresponding EFV curves. HYSYS- and CHEMCAD-estimated curves were compared to those produced by two traditional estimation methods (Edmister’s and Maswell’s methods. Simulation-estimated curves were close to average Edmister and Maxwell curves in all cases. The propo-sed method has several advantages; it avoids the need for experimentally obtaining an EFV curve, it does not de-pend on the type of experimental curve used to fit the model and it enables estimating several pressures by using just one experimental curve as data.
Minimum airflow reset of single-duct VAV terminal boxes
Cho, Young-Hum
Single duct Variable Air Volume (VAV) systems are currently the most widely used type of HVAC system in the United States. When installing such a system, it is critical to determine the minimum airflow set point of the terminal box, as an optimally selected set point will improve the level of thermal comfort and indoor air quality (IAQ) while at the same time lower overall energy costs. In principle, this minimum rate should be calculated according to the minimum ventilation requirement based on ASHRAE standard 62.1 and maximum heating load of the zone. Several factors must be carefully considered when calculating this minimum rate. Terminal boxes with conventional control sequences may result in occupant discomfort and energy waste. If the minimum rate of airflow is set too high, the AHUs will consume excess fan power, and the terminal boxes may cause significant simultaneous room heating and cooling. At the same time, a rate that is too low will result in poor air circulation and indoor air quality in the air-conditioned space. Currently, many scholars are investigating how to change the algorithm of the advanced VAV terminal box controller without retrofitting. Some of these controllers have been found to effectively improve thermal comfort, indoor air quality, and energy efficiency. However, minimum airflow set points have not yet been identified, nor has controller performance been verified in confirmed studies. In this study, control algorithms were developed that automatically identify and reset terminal box minimum airflow set points, thereby improving indoor air quality and thermal comfort levels, and reducing the overall rate of energy consumption. A theoretical analysis of the optimal minimum airflow and discharge air temperature was performed to identify the potential energy benefits of resetting the terminal box minimum airflow set points. Applicable control algorithms for calculating the ideal values for the minimum airflow reset were developed and
Interplay between various degrees of freedom in determining the aspect of the caloric curve
Raduta, A H
1999-01-01
A sharp microcanonical model is used to investigate the primary decay nuclear caloric curve. A wide plateau of the caloric curve corresponding to a temperature of around 5 MeV, sign of liquid-gas phase transition, is evidenced for three sample nuclei. The results are resembling the experimental data of Pochodzalla et al. [Phys. Rev. Lett. 75 (1995) 1040]. Calculated He-Li temperatures manifest a similar behavior. Correlations between different parts of the caloric curves and the energy amounts deposited in the available degrees are discussed. The extent to which the existent degrees of freedom are contributing to the shape of the caloric curve is commented.
Phase resetting reveals network dynamics underlying a bacterial cell cycle.
Yihan Lin
Full Text Available Genomic and proteomic methods yield networks of biological regulatory interactions but do not provide direct insight into how those interactions are organized into functional modules, or how information flows from one module to another. In this work we introduce an approach that provides this complementary information and apply it to the bacterium Caulobacter crescentus, a paradigm for cell-cycle control. Operationally, we use an inducible promoter to express the essential transcriptional regulatory gene ctrA in a periodic, pulsed fashion. This chemical perturbation causes the population of cells to divide synchronously, and we use the resulting advance or delay of the division times of single cells to construct a phase resetting curve. We find that delay is strongly favored over advance. This finding is surprising since it does not follow from the temporal expression profile of CtrA and, in turn, simulations of existing network models. We propose a phenomenological model that suggests that the cell-cycle network comprises two distinct functional modules that oscillate autonomously and couple in a highly asymmetric fashion. These features collectively provide a new mechanism for tight temporal control of the cell cycle in C. crescentus. We discuss how the procedure can serve as the basis for a general approach for probing network dynamics, which we term chemical perturbation spectroscopy (CPS.
Isodose curve determination of prostate for the treatment of brachytherapy using MCNPX code
Reis Junior, J.P.; Menezes, A.F.; Medeiros, J.A.C.C., E-mail: jjunior@con.ufrj.br, E-mail: ademir@con.ufrj.br, E-mail: amenezes@con.ufrj.br [Universidade Federal do Rio de Janeiro (UFRJ/COPPE/PEN), RJ (Brazil). Coord. dos Programas de Pos-Graduacao em Engenharia. Programa de Engenharia Nuclear; Salmom, H.A., E-mail: heliosalmom@coinet.com.br [MD.X Barra Medical Center, Barra da Tijuca, Rio de Janeiro, RJ (Brazil); Facure, A.N.S.S., E-mail: facure@cnen.gov.br [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Silva, A.X. [Universidade Federal do Rio de Janeiro (UFRJ/DEN), Rio de Janeiro, RJ (Brazil). Escola Politecnica. Dept. de Engenharia Nuclear
2011-07-01
Using voxel phantom MAX 06 coupled to the code MCNPX it possible to plot the isodose curves for the main levels involved in the treatment of prostate brachytherapy, V100 and V150 which are, respectively corresponding curves 144 and 216 Gy to curves are indicative of the quality of the existing implant of prostate brachytherapy. The number of 79 seeds {sup 125}I, were placed in the voxels simulator MAX 06, in the slices x = 7.0, 7.5, 8.0, 8.5, 9.0, 9.5, 10.0 with the calculation model used in MCNPX in all voxels present in a matrix, it was possible to trace the isodose curves for MATLAB. For comparison and using own routines MCNPX it was possible to trace the same curves using mesh tallies. The results showed agreement with predicted values in the planning system prowess 3D. (author)
Singh, Harkirat; Wahi, Pankaj
2017-08-01
The motion of a string in the presence of a doubly curved obstacle is investigated. A mathematical model has been developed for a general shape of the obstacle. However, detailed analysis has been performed for a shape relevant to the Indian stringed musical instruments like Tanpura and Sitar. In particular, we explore the effect of obstacle's curvature in the plane perpendicular to the string axis on its motion. This geometrical feature of the obstacle introduces a coupling between motions in mutually perpendicular directions over and above the coupling due to the stretching nonlinearity. We find that only one planar motion is possible for our system. Small amplitude planar motions are stable to perturbations in the perpendicular direction resulting in non-whirling motions while large amplitude oscillations lead to whirling motions. The critical amplitude of oscillations, across which there is a transition in the qualitative behavior of the non-planar trajectories, is determined using Floquet theory. Our analysis reveals that a small obstacle curvature in a direction perpendicular to the string axis leads to a considerable reduction in the critical amplitudes required for initiation of whirling motions. Hence, this obstacle curvature has a destabilizing effect on the planar motions in contrast to the curvature along the string axis which stabilizes planar motions.
Applications Determine the Best Model to Predict Flow Duration Curves in Ungauged Basins
Muller, M. F.; Thompson, S. E.
2014-12-01
Flow duration curves (FDCs) are an important tool for watershed management and their prediction in ungauged catchments is a challenging problem. Selecting the most appropriate model for prediction the FDC is itself a challenge that determines how theoretical improvements in prediction are transferred into engineering practice. Available performance metrics (e.g., Nash Sutcliffe Coefficient, error on flow moments) typically consider the aggregated ability of the model to predict all streamflow quantiles. These metrics may be inappropriate for model selection in practice because watershed management decisions are typically driven by a limited number of streamflow quantiles that may be poorly represented by an aggregate performance metric. As an illustrative case study, the performance of three distinct FDC prediction approaches -- graphical, statistical and process-based -- are compared for ungauged streams in Nepal. The practical application of these predictions is to inform the design of run-of-river hydropower plants. The process-based approach provides the best prediction of the observed flow distribution and results in significantly higher Nash coefficients. However, the graphical approach provides the best prediction of the flow quantiles that are most relevant for hydropower design and reduces the design error caused by streamflow estimation. To assist in an application driven model selection process, we propose a novel model selection framework.
Güerci, A; Zúñiga, L; Marcos, R
2011-01-01
Individual radiosensitivity is an individual characteristic associated with an increased reaction to ionizing radiation. The purpose of our work is to establish a dose-response curve useful to classify individuals as radiosensitive or radioresistant. Thus, a dose-response curve was constructed by measuring in vitro responses to increasing doses (0 to 8 Gy) of gamma radiation in the comet assay. The obtained curve fit well with a linear equation in the range of 0 to 8 Gy. The overall dose-response curve was constructed for percent DNA in tail, as a measure of the genetic damage induced by irradiation. To probe the goodness of the constructed curve, a validation study was carried out with whole blood from two donors in a blind study. Results show that, for the two applied doses (2 and 6 Gy), the obtained values fit well inside the interval of confidence of the curve. In conclusion, our results demonstrate the usefulness of the comet assay in determining individual responses to defined doses of gamma radiation. The standard dose-response curve constructed may be used to detect individuals departing from reference values.
More basic approach to the analysis of multiple specimen R-curves for determination of J/sub c/
Carlson, K.W.; Williams, J.A.
1980-02-01
Multiple specimen J-R curves were developed for groups of 1T compact specimens with different a/W values and depth of side grooving. The purpose of this investigation was to determine J/sub c/ (J at onset of crack extension) for each group. Judicious selection of points on the load versus load-line deflection record at which to unload and heat tint specimens permitted direct observation of approximate onset of crack extension. It was found that the present recommended procedure for determining J/sub c/ from multiple specimen R-curves, which is being considered for standardization, consistently yielded nonconservative J/sub c/ values. A more basic approach to analyzing multiple specimen R-curves is presented, applied, and discussed. This analysis determined J/sub c/ values that closely corresponded to actual observed onset of crack extension.
Well-Posedness of Reset Control Systems as State-Dependent Impulsive Dynamical Systems
Alfonso Baños
2012-01-01
existence and uniqueness of solutions, and in particular to the resetting times to be well defined and distinct. A sufficient condition is developed for a reset system to have well-posed resetting times, which is also a sufficient condition for avoiding Zeno solutions and, thus, for a reset control system to be well-posed.
Antokhina, E. A.; Menchenkova, E. V.
1990-06-01
Fresa's (1966) blue light curve of V367 Cyg is analyzed by the synthesis method in the framework of the Roche model and a model with a geometrically thick disk. The new spectroscopic mass ratio q = M2//M1 = 1.57 was used. The fundamental parameters and the absolute dimensions of the system were determined.
van Sark, W.G.J.H.M.; Alsema, E.A.; Junginger, H.M.; de Moor, H.H.C.; Schaeffer, G.J.
2008-01-01
Learning curves are extensively used in policy and scenario studies. Progress ratios (PRs) are derived from historical data and are used for forecasting cost development of many technologies, including photovoltaics (PV). Forecasts are highly sensitive to uncertainties in the PR. A PR usually is det
Spinler, E.A.; Baldwin, B.A. [Phillips Petroleum Co., Bartlesville, OK (United States)
1997-08-01
A method is being developed for direct experimental determination of capillary pressure curves from saturation distributions produced during centrifuging fluids in a rock plug. A free water level is positioned along the length of the plugs to enable simultaneous determination of both positive and negative capillary pressures. Octadecane as the oil phase is solidified by temperature reduction while centrifuging to prevent fluid redistribution upon removal from the centrifuge. The water saturation is then measured via magnetic resonance imaging. The saturation profile within the plug and the calculation of pressures for each point of the saturation profile allows for a complete capillary pressure curve to be determined from one experiment. Centrifuging under oil with a free water level into a 100 percent water saturated plug results in the development of a primary drainage capillary pressure curve. Centrifuging similarly at an initial water saturation in the plug results in the development of an imbibition capillary pressure curve. Examples of these measurements are presented for Berea sandstone and chalk rocks.
银河系自转曲线的测定%Rotation Curve Determination of the Milky Way Galaxy
赵君亮
2012-01-01
Measuring the Galactic rotation curve is of fundamental importance for solving a number of astrophysical problems, such as estimating the total mass of the Galaxy, de-termining the distribution of matter, exploring dark mater, studying the dynamics of the Galaxy and its subsystems, etc. Since 1930s the data on various kinds of population I objects as tracers have been used to determine the Galactic rotation curve, including classical Cepheids, planetary nebulae, C stars, young open clusters, OB stars, HI survey etc., and in many studies more than one kind of the above disk objects are synthetically used. With observational data accumulating, bigger and bigger samples of population I tracers have been used to determine the Galactic rotation curve. There are two different cases and methods for rotation curve determination. For the inner Galaxy(R< R①), it follows that the radial velocity components in a given direction reach a maximum in the point nearest to the galactic center, and the circular velocities can be easily found even with distances of tracers from the Sun being unknown, which is called as the tangential point method. For the outer Galaxy(R ≥ R②), both radial velocities and heliocentric distances of tracers must be independently measured in order to determine their circular velocities. By the end of the 20th century and later, in addition to radial velocities, proper motion data are also used for rotation curve studies. So far as HI survey data are concerned, some different approaches are used to explore the Galactic rotation curve, for instance, from changes of the thickness of the HI layers with different heliocentric distances. Up to now, it is consistently shown from almost all of different studies on the Galactic rotation curve from different tracers that the rotation curve of the outer Galaxy is roughly flat or appears to rise slightly from the Sun's location to the heliocentric distance of 20 kpc. On the other side, from a recent study on the
Continuous-time random walks with reset events. Historical background and new perspectives
Montero, Miquel; Masó-Puigdellosas, Axel; Villarroel, Javier
2017-09-01
In this paper, we consider a stochastic process that may experience random reset events which relocate the system to its starting position. We focus our attention on a one-dimensional, monotonic continuous-time random walk with a constant drift: the process moves in a fixed direction between the reset events, either by the effect of the random jumps, or by the action of a deterministic bias. However, the orientation of its motion is randomly determined after each restart. As a result of these alternating dynamics, interesting properties do emerge. General formulas for the propagator as well as for two extreme statistics, the survival probability and the mean first-passage time, are also derived. The rigor of these analytical results is verified by numerical estimations, for particular but illuminating examples.
Dynamic tensile testing for determining the stress-strain curve at different strain rate
Mansilla, A; Regidor, A.; García, D.; Negro, A
2001-01-01
A detailed discussion of high strain-rate tensile testing is presented. A comparative analysis of different ways to measure stress and strain is made. The experimental stress-strain curves have been suitably interpreted to distinguish between the real behaviour of the material and the influence of the testing methodology itself. A special two sections flat specimen design was performed through FEA computer modelling. The mechanical properties as function of strain rate were experimentally obt...
Empirical determination of the shape of dust attenuation curves in star-forming galaxies
Wild, Vivienne; Brinchmann, Jarle; Heckman, Timothy; Vince, Oliver; Pacifici, Camilla; Chevallard, Jacopo
2011-01-01
We present a systematic study of the shape of the dust attenuation curve in star-forming galaxies from the far ultraviolet to the near infrared (0.15-2microns), as a function of specific star formation rate (sSFR) and axis ratio (b/a), for galaxies with and without a significant bulge. Our sample comprises 23,000 (15,000) galaxies with a median redshift of 0.07, with photometric entries in the SDSS, UKIDSS-LAS (and GALEX-AIS) survey catalogues and emission line measurements from the SDSS spectroscopic survey. We develop a new pair-matching technique to isolate the dust attenuation curves from the stellar continuum emission. The main results are: (i) the slope of the attenuation curve in the optical varies weakly with sSFR, strongly with b/a, and is significantly steeper than the Milky Way extinction law in bulge-dominated galaxies; (ii) the NIR slope is constant, and matches the slope of the Milky Way extinction law; (iii) the UV has a slope change consistent with a dust bump at 2175AA which is evident in all...
Lemoine, X.; Sriram, S.; Kergen, R.
2011-05-01
ArcelorMittal continuously develops new steel grades (AHSS) with high performance for the automotive industry to improve the weight reduction and the passive safety. The wide market introduction of AHSS raises a new challenge for manufacturers in terms of material models in the prediction of forming—especially formability and springback. The relatively low uniform elongation, the high UTS and the low forming limit curve of these AHSS may cause difficulties in forming simulations. One of these difficulties is the consequence of the relatively low uniform elongation on the parameters identification of isotropic hardening model. Different experimental tests allow to reach large plastic strain levels (hydraulic bulge test, stack compression test, shear test…). After a description on how to determine the flow curve in these experimental tests, a comparison of the different flow curves is made for different steel grades. The ArcelorMittal identification protocol for hardening models is only based on stress-strain curves determined in uniaxial tension. Experimental tests where large plastic strain levels are reached are used to validate our identification protocol and to recommend some hardening models. Finally, the influence of isotropic hardening models and yield loci in forming prediction for AHSS steels will be presented.
Stochastic resetting in backtrack recovery by RNA polymerases
Roldán, Édgar; Sánchez-Taltavull, Daniel; Grill, Stephan W
2016-01-01
Transcription is a key process in gene expression, in which RNA polymerases produce a complementary RNA copy from a DNA template. RNA polymerization is frequently interrupted by backtracking, a process in which polymerases perform a random walk along the DNA template. Recovery of polymerases from the transcriptionally-inactive backtracked state is determined by a kinetic competition between 1D diffusion and RNA cleavage. Here we describe backtrack recovery as a continuous-time random walk, where the time for a polymerase to recover from a backtrack of a given depth is described as a first-passage time of a random walker to reach an absorbing state. We represent RNA cleavage as a stochastic resetting process, and derive exact expressions for the recovery time distributions and mean recovery times from a given initial backtrack depth for both continuous and discrete-lattice descriptions of the random walk. We show that recovery time statistics do not depend on the discreteness of the DNA lattice when the rate o...
Paula, Vanderson Rabelo de [Universidade de Sao Paulo (ESALQ/USP), Piracicaba, SP (Brazil). Escola Superior de Agricultura Luiz de Queiroz; Silva, Breno Alves; Santos, Thiago Castro Vidal dos; Porto, Rodrigo Padovani; Volpato, Carlos Eduardo Silva; Barbosa, Jackson Antonio [Universidade Federal de Lavras (UFLA), MG (Brazil)
2008-07-01
The globalization of the economy has approached the markets and one of the consequences of this approach is the entrance of new equipment and highly competitive machines in cost terms. This is the same reality of the Brazilian agricultural sector that today counts on new options of machines and very interesting implements of the point of view of the acquisition cost. In this context, this work aimed at the dynamometric assay of an agricultural tractor for attainment of its curves of torque, power using the B100 soybean fuels, B100 olive, B100 diesel. (author)
Vosough, Maryam; Mohamedian, Hadi; Salemi, Amir; Baheri, Tahmineh
2015-02-01
In the present study, a simple strategy based on solid-phase extraction (SPE) with a cation exchange sorbent (Finisterre SCX) followed by fast high-performance liquid chromatography (HPLC) with diode array detection coupled with chemometrics tools has been proposed for the determination of methamphetamine and pseudoephedrine in ground water and river water. At first, the HPLC and SPE conditions were optimized and the analytical performance of the method was determined. In the case of ground water, determination of analytes was successfully performed through univariate calibration curves. For river water sample, multivariate curve resolution and alternating least squares was implemented and the second-order advantage was achieved in samples containing uncalibrated interferences and uncorrected background signals. The calibration curves showed good linearity (r(2) > 0.994).The limits of detection for pseudoephedrine and methamphetamine were 0.06 and 0.08 μg/L and the average recovery values were 104.7 and 102.3% in river water, respectively.
Demonstrating a driven reset protocol for a superconducting qubit.
Geerlings, K; Leghtas, Z; Pop, I M; Shankar, S; Frunzio, L; Schoelkopf, R J; Mirrahimi, M; Devoret, M H
2013-03-22
Qubit reset is crucial at the start of and during quantum information algorithms. We present the experimental demonstration of a practical method to force qubits into their ground state, based on driving appropriate qubit and cavity transitions. Our protocol, called the double drive reset of population, is tested on a superconducting transmon qubit in a three-dimensional cavity. Using a new method for measuring population, we show that we can prepare the ground state with a fidelity of at least 99.5% in less than 3 μs; faster times and higher fidelity are predicted upon parameter optimization.
Scislo, Tadeusz J; Ichinose, Tomoko K; O'Leary, Donal S
2008-01-01
Previously we showed that pressor and differential regional sympathoexcitatory responses (adrenal > renal >/= lumbar) evoked by stimulation of A(1) adenosine receptors located in the nucleus of the solitary tract (NTS) were attenuated/abolished by baroreceptor denervation or blockade of glutamatergic transmission in the NTS, suggesting A(1) receptor-elicited inhibition of glutamatergic transmission in baroreflex pathways. Therefore we tested the hypothesis that stimulation of NTS A(1) adenosine receptors differentially inhibits/resets baroreflex responses of preganglionic adrenal (pre-ASNA), renal (RSNA), and lumbar (LSNA) sympathetic nerve activity. In urethane-chloralose-anesthetized male Sprague-Dawley rats (n = 65) we compared baroreflex-response curves (iv nitroprusside and phenylephrine) evoked before and after bilateral microinjections into the NTS of A(1) adenosine receptor agonist (N(6)-cyclopentyladenosine, CPA; 0.033-330 pmol/50 nl). CPA evoked typical dose-dependent pressor and differential sympathoexcitatory responses and similarly shifted baroreflex curves for pre-ASNA, RSNA, and LSNA toward higher mean arterial pressure (MAP) in a dose-dependent manner; the maximal shifts were 52.6 +/- 2.8, 48.0 +/- 3.6, and 56.8 +/- 6.7 mmHg for pre-ASNA, RSNA, and LSNA, respectively. These shifts were not a result of simple baroreceptor resetting because they were two to three times greater than respective increases in baseline MAP evoked by CPA. Baroreflex curves for pre-ASNA were additionally shifted upward: the maximal increases of upper and lower plateaus were 41.8 +/- 16.4% and 45.3 +/- 8.7%, respectively. Maximal gain (%/mmHg) measured before vs. after CPA increased for pre-ASNA (3.0 +/- 0.6 vs. 4.9 +/- 1.3), decreased for RSNA (4.1 +/- 0.6 vs. 2.3 +/- 0.3), and remained unaltered for LSNA (2.1 +/- 0.2 vs. 2.0 +/- 0.1). Vehicle control did not alter the baroreflex curves. We conclude that the activation of NTS A(1) adenosine receptors differentially inhibits/resets
Determination of Curve Number for snowmelt-runoff floods in a small catchment
Hejduk, L.; Hejduk, A.; Banasik, K.
2015-06-01
One of the widely used methods for predicting flood runoff depth from ungauged catchments is the curve number (CN) method, developed by Soil Conservation Service (SCS) of US Department of Agriculture. The CN parameter can be computed directly from recorded rainfall depths and direct runoff volumes in case of existing data. In presented investigations, the CN parameter has been computed for snowmelt-runoff events based on snowmelt and rainfall measurements. All required data has been gathered for a small agricultural catchment (A = 23.4 km2) of Zagożdżonka river, located in Central Poland. The CN number received from 28 snowmelt-runoff events has been compared with CN computed from rainfall-runoff events for the same catchment. The CN parameter, estimated empirically varies from 64.0 to 94.8. The relation between CN and snowmelt depth was investigated in a similar procedure to relation between CN and rainfall depth.
Determination of suitable drying curve model for bread moisture loss during baking
Soleimani Pour-Damanab, A. R.; Jafary, A.; Rafiee, S.
2013-03-01
This study presents mathematical modelling of bread moisture loss or drying during baking in a conventional bread baking process. In order to estimate and select the appropriate moisture loss curve equation, 11 different models, semi-theoretical and empirical, were applied to the experimental data and compared according to their correlation coefficients, chi-squared test and root mean square error which were predicted by nonlinear regression analysis. Consequently, of all the drying models, a Page model was selected as the best one, according to the correlation coefficients, chi-squared test, and root mean square error values and its simplicity. Mean absolute estimation error of the proposed model by linear regression analysis for natural and forced convection modes was 2.43, 4.74%, respectively.
METHOD OF DETERMINING THE CURVE OF INTERSECTION BETWEEN A CYLINDRICAL SURFACE AND A TORUS
Ivona Petre
2010-01-01
Full Text Available The intersections of the cylindrical surfaces with a torus are often met in practice, for instance in the pneumatictransport installations for the intermediate products resulted from grist. The descriptive geometry is the foundation ofthe engineering sciences, giving force looking into space, much necessary to the specialists in this domain. She is theway to solve the problems in design and is one interdisciplinary link in the training of specialists in engineeringscience.The general method of construction of the curve of intersection of two surfaces is to find as many of its points, that itcan be drawn as accurately. Such points can be found using auxiliary surfaces (plan or spherical, which intersects thefirsts. The paper solves graphical one of these applications, using the classical method of the descriptive geometry.
ESTIMATION UNCERTAINTY IN THE DETERMINATION OF THE MASTER CURVE REFERENCE TEMPERATURE
Sham, Sam [ORNL; Eno, Daniel R [Bechtel Marine Propulsion Corporation
2010-01-01
The Master Curve Reference Temperature, T0, characterizes the fracture performance of structural steels in the ductile-to-brittle transition region. For a given material, this reference temperature is estimated via fracture toughness testing. A methodology is presented to compute the standard error of an estimated T0 value from a finite sample of toughness data, in a unified manner for both single temperature and multiple temperature test methods. Using the asymptotic properties of maximum likelihood estimators, closed-form expressions for the standard error of the estimate of T0 are presented for both test methods. This methodology includes statistically rigorous treatment of censored data, which represents an advance over the current ASTM E1921 methodology. Through Monte Carlo simulations of realistic single temperature and multiple temperature test plans, the recommended likelihood-based procedure is shown to provide better statistical performance than the methods in the ASTM E1921 standard.
Dai, Jiayu; Zhao, Zengxiu; Wu, Yanqun; Yuan, Jianmin
2011-01-01
A new determined principal Hugoniot curve of Fe in the temperature range of 0.1-100 eV from Ab initio is presented, and the structural dynamics along this curve is shown. All experiments are on top or above our Hugoniot data, which are along the lower envelop of the distribution of experiments. The present data are the converged limit for experiments to remove the external effects such as preheating. In particular, the experimental data on the bottom of the distribution below 10 Mbar can be considered nearly free of errors caused by the external effects compared with our data. The dynamics of ionic structures shows the stable existence of complex clusters with persisted time length of hundreds of femto-seconds from cold to hot dense matter.
Becker, Maik; Bredemeyer, Niels; Tenhumberg, Nils; Turek, Thomas
2016-03-01
Potential probes are applied to vanadium redox-flow batteries for determination of effective felt resistance and current density distribution. During the measurement of polarization curves in 100 cm2 cells with different carbon felt compression rates, alternating potential steps at cell voltages between 0.6 V and 2.0 V are applied. Polarization curves are recorded at different flow rates and states of charge of the battery. Increasing compression rates lead to lower effective felt resistances and a more uniform resistance distribution. Low flow rates at high or low state of charge result in non-linear current density distribution with high gradients, while high flow rates give rise to a nearly linear behavior.
Song-hao SHANG; Xiao-min MAO
2010-01-01
Floods are essential for the regeneration and growth of floodplain forests in arid and semiarid regions.However,river flows,and especially flood flows,have decreased greatly with the increase of water diversion from rivers and/or reservoir regulation,resulting in severe deterioration of floodplain ecosystems.Estimation of the flood stage that will inundate the floodplain forest is necessary for the forest's restoration or protection.To balance water use for economic purposes and floodplain forest protection,the inundated forest width method is proposed for estimating the minimum flood stage for floodplain forests from the inundated forest width-stage curve.The minimum flood stage is defined as the breakpoint of the inundated forest width-stage curve,and is determined directly or analytically from the curve.For the analytical approach,the problem under consideration is described by a multi-objective optimization model,which can be solved by the ideal point method.Then,the flood flow at the minimum flood stage(minimum flood flow),which is useful for flow regulation,can be calculated from the stage-discharge curve.In order to protect the forest in a river floodplain in a semiarid area in Xinjiang subject to reservoir regulation upstream,the proposed method was used to determine the minimum flood stage and flow for the forest.Field survey of hydrology,topography,and forest distribution was carried out at typical cross sections in the floodplain.Based on the survey results,minimum flood flows for six typical cross sections were estimated to be between 306 m3/s and 393 m3/s.Their maximum,393 m3/s,was considered the minimum flood flow for the study river reach.This provides an appropriate flood flow for the protection of floodplain forest and can be used in the regulation of the upstream reservoir.
Lachenmeier, Dirk W; Kessler, Waltraud
2008-07-23
In the analysis of food additives, past emphasis was put on the development of chromatographic techniques to separate target components from a complex matrix. Especially in the case of artificial food colors, direct spectrophotometric measurement was seen to lack in specificity due to a high spectral overlap between different components. Multivariate curve resolution (MCR) may be used to overcome this limitation. MCR is able to (i) extract from a complex spectral feature the number of involved components, (ii) attribute the resulting spectra to chemical compounds, and (iii) quantify the individual spectral contributions with or without a priori knowledge. We have evaluated MCR for the routine analysis of yellow and blue food colors in absinthe spirits. Using calibration standards, we were able to show that MCR equally performs as compared to partial least-squares regression but with much improved chemical information contained in the predicted spectra. MCR was then applied to an authentic collective of different absinthes. As confirmed by reference analytics, the food colors were correctly assigned with a sensitivity of 0.93 and a specificity of 0.85. Besides the artificial colors, the algorithm detected a further component in some samples that could be assigned to natural coloring from chlorophyll.
Chen, Ya-Mei; Chen, Duan-Rung; Chiang, Tung-Liang; Tu, Yu-Kang; Yu, Hsiao-Wei
2016-01-01
Our aim was to identify disablement factors, including predisposing, intra-individual, and extra-individual factors, which predict the rate of change in general functional disability (GFD) in older adults. This study utilized the Taiwan Longitudinal Study on Aging Survey in 1996-2007 (N=3,186). Multiple-indicator latent growth curve modeling was used to examine how 12 disablement factors predicted the rate of change in GFD. GFD trajectories were modeled using Nagi's functional limitations, activities of daily living, and instrumental activities of daily living. Greater age (B=.025), female gender (B=.114), and greater numbers of comorbidities (B=.038) were associated with faster increase in GFD. Education (B=-.005) and participation in physically active leisure time activities (B=-.031) were associated with slower increase in GFD. Our findings add to the understanding of how disablement factors contribute to the rate of change in GFD. Predisposing factors played the main role. However, the factors we found to be associated with the rate of change in GFD in older adults were slightly different from the factors reported in the literature. Decreasing the number of comorbidities and increasing the level of physically active leisure time activity should be considered priorities for preventing disability as people age.
Phase reset affects auditory-visual simultaneity judgment.
Kambe, Jun; Kakimoto, Yuta; Araki, Osamu
2015-10-01
We continuously receive the external information from multiple sensors simultaneously. The brain must judge a source event of these sensory informations and integrate them. It is thought that judging the simultaneity of such multisensory stimuli is an important cue when we discriminate whether the stimuli are derived from one event or not. Although previous studies have investigated the correspondence between an auditory-visual (AV) simultaneity perceptions and the neural responses, there are still few studies of this. Electrophysiological studies have reported that ongoing oscillations in human cortex affect perception. Especially, the phase resetting of ongoing oscillations has been examined as it plays an important role in multisensory integration. The aim of this study was to investigate the relationship of phase resetting for the judgment of AV simultaneity judgement tasks. The subjects were successively presented with auditory and visual stimuli with intervals that were controlled as [Formula: see text] and they were asked to report whether they perceived them simultaneously or not. We investigated the effects of the phase of ongoing oscillations on simultaneity judgments with AV stimuli with SOAs in which the detection rate of asynchrony was 50 %. It was found that phase resetting at the beta frequency band in the brain area that related to the modality of the following stimulus occurred after preceding stimulus onset only when the subjects perceived AV stimuli as simultaneous. This result suggested that beta phase resetting occurred in areas that are related to the subsequent stimulus, supporting perception multisensory stimuli as simultaneous.
Efficient Identification Scheme Provably Secure Against Reset Attack
ZHUHuafei; LIUJianwei; JIANGRuzhong; FENGDengguo
2004-01-01
Smart cards have been used extensively in practice, e.g., in user access control and secure electronic commerce. Since a smart card is no more than some electronic device embedded with a desired chip capable for processing private information, it is vulnerable to the reset attack. We remark that the reset attack is a real security concern since a malicious user can simply disconnect its battery so as to reset its content to the initial state and then re-insert the battery and use it with that state a number of times if the smart card is available to the malicious users, e.g., in the cases that a smart card is lost or is stolen. In this report, we develop an efficient identification scheme based on Cramer-Shoup's test function.The scheme is provably secure against reset attack under post-processing model provided there are the hardness assumption of the decisional Diffie-Hellman problem as well as the existence of collision free hash functions.
Colson, Russell O.; Haskin, Larry A.; Crane, Daniel
1990-01-01
Results are presented on determinations of reduction potentials and their temperature dependence of selected ions in diopsidic melt, by using linear sweep voltammetry. Diffusion coefficients were measured for cations of Eu, Mn, Cr, and In. Enthalpies and entropies of reduction were determined for the cations V(V), Cr(3+), Mn(2+), Mn(3+), Fe(2+), Cu(2+), Mo(VI), Sn(IV), and Eu(3+). Reduction potentials were used to study the structural state of cations in the melt.
Reliability of temperature determination from curve-fitting in multi-wavelength pyrometery
Ni, P. A.; More, R. M.; Bieniosek, F. M.
2013-08-04
Abstract This paper examines the reliability of a widely used method for temperature determination by multi-wavelength pyrometry. In recent WDM experiments with ion-beam heated metal foils, we found that the statistical quality of the fit to the measured data is not necessarily a measure of the accuracy of the inferred temperature. We found a specific example where a second-best fit leads to a more realistic temperature value. The physics issue is the wavelength-dependent emissivity of the hot surface. We discuss improvements of the multi-frequency pyrometry technique, which will give a more reliable determination of the temperature from emission data.
Marek Krynke
2013-02-01
Full Text Available In slewing bearings, a great number of contact pairs are present on the contact surfaces between the rolling elements and raceways of the bearing. Computations to determine the load of the individual rolling elements, taking into account the flexibility of the bearing ring, are most often carried out using the finite element method. Construction of a FEM full model of the bearing, taking into account the shape of the rolling elements and the determination of the contact problem for every rolling element, leads to a singularity of stiffness matrix, which in turn makes the problem impossible to solve. In FEM models the rolling elements are replaced by one-dimensional finite elements (linear elements to simplify the computation procedure and to obtain an optimal time for computations. replaced by truss elements with a material non-linear characteristic located between the raceway centres of the curvatures in their axial section, are presented in the paper
Song-hao Shang
2010-09-01
Full Text Available Flood is essential for the regeneration and growth of floodplain forests in arid and semiarid regions. However, river flow, especially the flood, had changed greatly with the increase of water diversion from rivers and/or reservoir regulation, which may result in severer deterioration of the floodplain ecosystems. The estimation of appropriate flood stage to inundate the floodplain forests is necessary for their restoration or protection in flow regulation. To balance the economical water use and flood for the floodplain forest, we proposed the inundated forest width method to estimate minimum flood stage for floodplain forests from the inundated forest width – stage curve. The minimum flood stage was defined as the breakpoint of the inundated forest width – stage curve, and could be determined directly from the curve or analytically. For the latter case, the problem under consideration was described by a multi-objective optimization model, which can be solved by the ideal point method. In order to protect the forest in a river floodplain in semiarid area in Xinjiang that subjected to reservoir regulation in the upstream, the proposed method was used to determine the minimum flood stage and flow for the forest. Field survey on hydrology, topography and forest distribution was carried out at representative cross sections in the floodplain. Based on the surveying results, minimum flood flows for six representative cross sections were estimated to be 306 m3/s to 393 m3/s. Their maximum, 393 m3/s, was taken as the minimum flood flow for the studying river reach. It provides an appropriate flood flow for the protection of floodplain forest and can be used in the regulation of the upstream reservoir.
The Determinant Bundle on the Moduli Space of Stable Triples over a Curve
Indranil Biswas; N Raghavendra
2002-08-01
We construct a holomorphic Hermitian line bundle over the moduli space of stable triples of the form (1, 2, ), where 1 and 2 are holomorphic vector bundles over a fixed compact Riemann surface , and : 2 → 1 is a holomorphic vector bundle homomorphism. The curvature of the Chern connection of this holomorphic Hermitian line bundle is computed. The curvature is shown to coincide with a constant scalar multiple of the natural Kähler form on the moduli space. The construction is based on a result of Quillen on the determinant line bundle over the space of Dolbeault operators on a fixed ∞ Hermitian vector bundle over a compact Riemann surface.
Marek Krynke
2013-03-01
Full Text Available In slewing bearings, a great number of contact pairs are present on the contact surfaces between the rolling elements and raceways of the bearing. Computations to determine the load of the individual rolling elements, taking into account the flexibility of the bearing ring, are most often carried out using the finite element method. Construction of a FEM full model of the bearing, taking into account the shape of the rolling elements and the determination of the contact problem for every rolling element, leads to a singularity of stiffness matrix, which in turn makes the problem impossible to solve. In FEM models the rolling elements are replaced by one-dimensional finite elements (linear elements to simplify the computation procedure and to obtain an optimal time for computations. The methods of modelling the rolling elements in the slewing bearing, in which balls have been replaced by truss elements with a material non-linear characteristic located between the raceway centres of the curvatures in their axial section, are presented in the paper.
Resetting of the carotid arterial baroreflex during dynamic exercise in humans
Norton, K H; Boushel, Robert Christopher; Andersen, Line Strange
1999-01-01
alone was performed at 50 and 75% VO(2 max), and L exercise combined with arm (A) exercise (L + A) was performed at 75 and 100% VO(2 max). O(2) consumption and heart rate (HR) increased in direct relation with the increases in exercise intensity. The threshold and saturation pressures of the carotid.......07). Similar changes were observed for the carotid-vasomotor reflex. In addition, as exercise intensity increased, the operating point (the prestimulus blood pressure) of the CBR was significantly relocated further from the centering point (G(max)) of the stimulus-response curve and was at threshold during 100......% VO(2 max). These findings identify the continuous classic rightward and upward resetting of the CBR, without a change in G(max), during increases in dynamic exercise intensity to maximal effort....
A Novel Augmented UD Identification with Resetting Strategy
无
2002-01-01
Augmented UD identification (AUDI) technique is derived from the traditional recursive least-squares algorithm and had been developed rapidly during last decade. However, as the identification process evolves, AUDI algorithm falls easily into identification saturation, which means that AUDI algorithm cannot respond to time-varying system parameters unless a set of very strong identification signals is utilized or a long identification period is occupied. To overcome such a difficulty, a novel resetting AUDI (RAUDI) strategy is advanced by resetting the augmented information matrix based on MF (Monitor Function) monitoring the conspicuous change of process parameters. The numeric experiment demonstrates that the RAUDI has a good performance in estimation of rapid parameter changes.
EEG PHASE RESET OF THE DEFAULT MODE NETWORK
Thatcher, Robert W.; North, Duane M.; Biver, Carl J.
2014-01-01
Objectives: The purpose of this study was to explore phase reset of 3-dimensional current sources located in Brodmann areas located in the human default mode network (DMN) using Low Resolution Electromagnetic Tomography (LORETA) of the human electroencephalogram (EEG). Methods: The EEG was recorded from 19 scalp locations from 70 healthy normal subjects ranging in age from 13 to 20 years. A time point by time point computation of LORETA current sources were computed for 14 Brodman areas c...
Shape memory alloy resetable spring lift for pedestrian protection
Barnes, Brian M.; Brei, Diann E.; Luntz, Jonathan E.; Strom, Kenneth; Browne, Alan L.; Johnson, Nancy
2008-03-01
Pedestrian protection has become an increasingly important aspect of automotive safety with new regulations taking effect around the world. Because it is increasingly difficult to meet these new regulations with traditional passive approaches, active lifts are being explored that increase the "crush zone" between the hood and rigid under-hood components as a means of mitigating the consequences of an impact with a non-occupant. Active lifts, however, are technically challenging because of the simultaneously high forces, stroke and quick timing resulting in most of the current devices being single use. This paper introduces the SMArt (Shape Memory Alloy ReseTable) Spring Lift, an automatically resetable and fully reusable device, which couples conventional standard compression springs to store the energy required for a hood lift, with Shape Memory Alloys actuators to achieve both an ultra high speed release of the spring and automatic reset of the system for multiple uses. Each of the four SMArt Device subsystems, lift, release, lower and reset/dissipate, are individually described. Two identical complete prototypes were fabricated and mounted at the rear corners of the hood, incorporated within a full-scale vehicle testbed at the SMARTT (Smart Material Advanced Research and Technology Transfer) lab at University of Michigan. Full operational cycle testing of a stationary vehicle in a laboratory setting confirms the ultrafast latch release, controlled lift profile, gravity lower to reposition the hood, and spring recompression via the ratchet engine successfully rearming the device for repeat cycles. While this is only a laboratory demonstration and extensive testing and development would be required for transition to a fielded product, this study does indicate that the SMArt Lift has promise as an alternative approach to pedestrian protection.
Dynamic stability and phase resetting during biped gait
Nomura, Taishin; Kawa, Kazuyoshi; Suzuki, Yasuyuki; Nakanishi, Masao; Yamasaki, Taiga
2009-06-01
Dynamic stability during periodic biped gait in humans and in a humanoid robot is considered. Here gait systems of human neuromusculoskeletal system and a humanoid are simply modeled while keeping their mechanical properties plausible. We prescribe periodic gait trajectories in terms of joint angles of the models as a function of time. The equations of motion of the models are then constrained by one of the prescribed gait trajectories to obtain types of periodically forced nonlinear dynamical systems. Simulated gait of the models may or may not fall down during gait, since the constraints are made only for joint angles of limbs but not for the motion of the body trunk. The equations of motion can exhibit a limit cycle solution (or an oscillatory solution that can be considered as a limit cycle practically) for each selected gait trajectory, if an initial condition is set appropriately. We analyze the stability of the limit cycle in terms of Poincaré maps and the basin of attraction of the limit cycle in order to examine how the stability depends on the prescribed trajectory. Moreover, the phase resetting of gait rhythm in response to external force perturbation is modeled. Since we always prescribe a gait trajectory in this study, reacting gait trajectories during the phase resetting are also prescribed. We show that an optimally prescribed reacting gait trajectory with an appropriate amount of the phase resetting can increase the gait stability. Neural mechanisms for generation and modulation of the gait trajectories are discussed.
GHK and DNA: Resetting the Human Genome to Health
Loren Pickart
2014-01-01
Full Text Available During human aging there is an increase in the activity of inflammatory, cancer promoting, and tissue destructive genes plus a decrease in the activity of regenerative and reparative genes. The human blood tripeptide GHK possesses many positive effects but declines with age. It improves wound healing and tissue regeneration (skin, hair follicles, stomach and intestinal linings, and boney tissue, increases collagen and glycosaminoglycans, stimulates synthesis of decorin, increases angiogenesis, and nerve outgrowth, possesses antioxidant and anti-inflammatory effects, and increases cellular stemness and the secretion of trophic factors by mesenchymal stem cells. Recently, GHK has been found to reset genes of diseased cells from patients with cancer or COPD to a more healthy state. Cancer cells reset their programmed cell death system while COPD patients’ cells shut down tissue destructive genes and stimulate repair and remodeling activities. In this paper, we discuss GHK’s effect on genes that suppress fibrinogen synthesis, the insulin/insulin-like system, and cancer growth plus activation of genes that increase the ubiquitin-proteasome system, DNA repair, antioxidant systems, and healing by the TGF beta superfamily. A variety of methods and dosages to effectively use GHK to reset genes to a healthier state are also discussed.
Effects of the Factory Reset on Mobile Devices
Riqui Schwamm
2014-09-01
Full Text Available Mobile devices usually provide a “factory-reset” tool to erase user-specific data from the main secondary storage. 9 Apple iPhones, 10 Android devices, and 2 BlackBerry devices were tested in the first systematic evaluation of the effectiveness of factory resets. Tests used the Cellebrite UME-36 Pro with the UFED Physical Analyzer, the Bulk Extractor open-source tool, and our own programs for extracting metadata, classifying file paths, and comparing them between images. Two phones were subjected to more detailed analysis. Results showed that many kinds of data were removed by the resets, but much user-specific configuration data was left. Android devices did poorly at removing user documents and media, and occasional surprising user data was left on all devices including photo images, audio, documents, phone numbers, email addresses, geolocation data, configuration data, and keys. A conclusion is that reset devices can still provide some useful information to a forensic investigation.
Zhang, S. Y.; Wang, G. F.; Wu, Y. T.; Baldwin, K. M. (Principal Investigator)
1993-01-01
On a partition chromatographic column in which the support is Kieselguhr and the stationary phase is sulfuric acid solution (2 mol/L), three components of compound theophylline tablet were simultaneously eluted by chloroform and three other components were simultaneously eluted by ammonia-saturated chloroform. The two mixtures were determined by computer-aided convolution curve method separately. The corresponding average recovery and relative standard deviation of the six components were as follows: 101.6, 1.46% for caffeine; 99.7, 0.10% for phenacetin; 100.9, 1.31% for phenobarbitone; 100.2, 0.81% for theophylline; 99.9, 0.81% for theobromine and 100.8, 0.48% for aminopyrine.
Ruta, Sergiu; Hovorka, Ondrej; Huang, Pin-Wei; Wang, Kangkang; Ju, Ganping; Chantrell, Roy
2017-03-01
The generic problem of extracting information on intrinsic particle properties from the whole class of interacting magnetic fine particle systems is a long standing and difficult inverse problem. As an example, the Switching Field Distribution (SFD) is an important quantity in the characterization of magnetic systems, and its determination in many technological applications, such as recording media, is especially challenging. Techniques such as the first order reversal curve (FORC) methods, were developed to extract the SFD from macroscopic measurements. However, all methods rely on separating the contributions to the measurements of the intrinsic SFD and the extrinsic effects of magnetostatic and exchange interactions. We investigate the underlying physics of the FORC method by applying it to the output predictions of a kinetic Monte-Carlo model with known input parameters. We show that the FORC method is valid only in cases of weak spatial correlation of the magnetisation and suggest a more general approach.
Ruta, Sergiu; Hovorka, Ondrej; Huang, Pin-Wei; Wang, Kangkang; Ju, Ganping; Chantrell, Roy
2017-01-01
The generic problem of extracting information on intrinsic particle properties from the whole class of interacting magnetic fine particle systems is a long standing and difficult inverse problem. As an example, the Switching Field Distribution (SFD) is an important quantity in the characterization of magnetic systems, and its determination in many technological applications, such as recording media, is especially challenging. Techniques such as the first order reversal curve (FORC) methods, were developed to extract the SFD from macroscopic measurements. However, all methods rely on separating the contributions to the measurements of the intrinsic SFD and the extrinsic effects of magnetostatic and exchange interactions. We investigate the underlying physics of the FORC method by applying it to the output predictions of a kinetic Monte-Carlo model with known input parameters. We show that the FORC method is valid only in cases of weak spatial correlation of the magnetisation and suggest a more general approach. PMID:28338056
Electron drift velocity in SF{sub 6} in strong electric fields determined from rf breakdown curves
Lisovskiy, V; Yegorenkov, V [Department of Physics and Technology, Kharkov National University, Svobody sq.4, Kharkov 61077 (Ukraine); Booth, J-P [Laboratoire de Physique des Plasmas, Ecole Polytechnique, Palaiseau 91128 (France); Landry, K [Unaxis Displays Division France SAS, 5, Rue Leon Blum, Palaiseau 91120 (France); Douai, D [Physical Sciences Division, Institute for Magnetic Fusion Research, CEA Centre de Cadarache, F-13108 Saint Paul lez Durance Cedex (France); Cassagne, V, E-mail: lisovskiy@yahoo.co [Developpement Photovoltaique Couches Minces, Total, 2, place Jean Millier, La Defense 6, 92400 Courbevoie (France)
2010-09-29
This paper presents measurements of the electron drift velocity V{sub dr} in SF{sub 6} gas for high reduced electric fields (E/N = 330-5655 Td (1 Td = 10{sup -17} V cm{sup 2})). The drift velocities were obtained using the method of Lisovskiy and Yegorenkov (1998 J. Phys. D: Appl. Phys. 31 3349) based on the determination of the pressure and voltage of the turning points of rf capacitive discharge breakdown curves for a range of electrode spacings. The V{sub dr} values thus obtained were in good agreement with those calculated from the cross-sections of Phelps and Van Brunt (1988 J. Appl. Phys. 64 4269) using the BOLSIG code. The validity of the Lisovskiy-Yegorenkov method is discussed and we show that it is applicable over the entire E/N range where rf discharge ignition at breakdown occurs for rf frequencies of 13.56 MHz or above.
Zhang, S. Y.; Wang, G. F.; Wu, Y. T.; Baldwin, K. M. (Principal Investigator)
1993-01-01
On a partition chromatographic column in which the support is Kieselguhr and the stationary phase is sulfuric acid solution (2 mol/L), three components of compound theophylline tablet were simultaneously eluted by chloroform and three other components were simultaneously eluted by ammonia-saturated chloroform. The two mixtures were determined by computer-aided convolution curve method separately. The corresponding average recovery and relative standard deviation of the six components were as follows: 101.6, 1.46% for caffeine; 99.7, 0.10% for phenacetin; 100.9, 1.31% for phenobarbitone; 100.2, 0.81% for theophylline; 99.9, 0.81% for theobromine and 100.8, 0.48% for aminopyrine.
Resetting of fluctuating interfaces at power-law times
Gupta, Shamik; Nagar, Apoorva
2016-11-01
What happens when the time evolution of a fluctuating interface is interrupted by resetting to a given initial configuration after random time intervals τ distributed as a power-law ∼ {τ }-(1+α ); α \\gt 0? For an interface of length L in one dimension, and an initial flat configuration, we show that depending on α, the dynamics in the limit L\\to ∞ exhibit a spectrum of rich long-time behavior. It is known that without resetting, the interface width grows unbounded with time as {t}β in this limit, where β is the so-called growth exponent characteristic of the universality class for a given interface dynamics. We show that introducing resetting leads to fluctuations that are bounded at large times for α \\gt 1. Corresponding to such a reset-induced stationary state is a distribution of fluctuations that is strongly non-Gaussian, with tails decaying as a power-law. The distribution exhibits a distinctive cuspy behavior for a small argument, implying that the stationary state is out of equilibrium. For α \\lt 1, on the contrary, resetting to the flat configuration is unable to counter the otherwise unbounded growth of fluctuations in time, so that the distribution of fluctuations remains time dependent with an ever-increasing width, even at long times. Although stationary for α \\gt 1, the width of the interface grows forever with time as a power-law for 1\\lt α \\lt {α }({{w})}, and converges to a finite constant only for larger α, thereby exhibiting a crossover at {α }({{w})}=1 + 2β . The time-dependent distribution of fluctuations exhibits for α \\lt 1 and for small arguments further interesting crossover behavior from cusp to divergence across {α }({{d})}=1-β . We demonstrate these results by exact analytical results for the paradigmatic Edwards–Wilkinson (EW) dynamical evolution of the interface, and further corroborate our findings by extensive numerical simulations of interface models in the EW and Kardar–Parisi–Zhang universality
Than Nándor
2010-02-01
Full Text Available Abstract Background Several studies have shown overexpression of leptin in microarray experiments in pre-eclampsia (PE and in hemolysis, elevated liver enzymes, low platelets (HELLP syndrome. We decided to study four leptin receptor (LEPR SNP polymorphisms in HELLP syndrome patients by using quantitative real-time PCR and melting curve analysis. Methods DNA was isolated from blood samples from 83 normotensive pregnant women and 75 HELLP syndrome patients. Four SNPs, LEPR c.326A>G (K109, LEPR c.668A>G (Q223R, LEPR c.1968G>C (K656N and LEPR c.3024A>G (S1008 were determined by quantitative real-time PCR and melting curve analysis. Investigators were blinded to clinical outcomes. Results LEPR c.326A>G, LEPR c.668A>G, LEPR c.1968G>C and LEPR c.3024A>G allele, genotype and haplotype polymorphisms were not different in HELLP syndrome patients and normotensive healthy pregnants. There were strong linkage disequilibrium (LD between loci c.326A>G and c.6687A>G (D' = 0.974, and c.668A>G and c.1968G>C (D' = 0.934, and c.326A>G and c.1968G>C (D' = 0.885, and c.1968G>C and c.3024A>G (D' = 1.0. However, linkages of c.3024A>G with c.668A>G (D' = 0.111 and c.326A>G (D' = 0.398 were weak. The Hardy-Weinberg equilibrium was observed for all polymorphisms. However the LEPR c.326A>G AG genotype was twice more frequent and the (AG AG GG AG haplotype was three times more frequent in HELLP syndrome patients. The introduced quantitative real-time PCR combined with melting curve analysis is a fast and reliable method for the determination of LEPR SNPs. Conclusion Although certain LEPR haplotypes are more frequent in HELLP syndrome, we conclude that there is no compelling evidence that the four studied LEPR SNP polymorphisms associated with the development of HELLP syndrome.
Chen, Xiang [ORNL; Nanstad, Randy K [ORNL; Sokolov, Mikhail A [ORNL
2014-01-01
Material ductile fracture toughness can be described by J-integral versus crack extension relationship (J-R curve). As a conventional J-R curve measurement method, unloading compliance (UC) becomes impractical in elevated temperature testing due to relaxation of the material and a friction induced back-up shape of the J-R curve. In addition, the UC method may underpredict the crack extension for standard disk-shaped compact (DC(T)) specimens. In order to address these issues, the normalization method and direct current potential drop (DCPD) technique were applied for determining J-R curves at 24 C and 500 C for 0.18T DC(T) specimens made from type 316L stainless steel. For comparison purchase, the UC method was also applied in 24 C tests. The normalization method was able to yield valid J-R curves in all tests. The J-R curves from the DCPD technique need adjustment to account for the potential drop induced by plastic deformation, crack blunting, etc. and after applying a newly-developed DCPD adjustment procedure, the post-adjusted DCPD J-R curves essentially matched J-R curves from the normalization method. In contrast, the UC method underpredicted the crack extension in all tests resulting in substantial deviation in the derived J-R curves manifested by high Jq values than the normalization or DCPD method. Only for tests where the UC method underpredicted the crack extension by a very small value, J-R curves determined by the UC method were similar to those determined by the normalization or DCPD method.
Heidarvand, Majid; Soltani, Naser; Hajializadeh, Farshid [University of Tehran, Tehran (Iran, Islamic Republic of)
2017-05-15
We determined the fracture toughness of aluminum curved thin sheets using tensile stress tests and finite element method. We applied Linear elastic fracture mechanics (LEFM) and Feddersen procedure to evaluate stress intensity factor of the samples with central wire-cut cracks and fatigue cracks with different lengths to investigate the notch radius effect. Special fixture design was utilized to establish uniform stress distribution at the crack zone. Less than 9 % difference was found between the wire-cut and the fatigue cracked samples. Since generating central fatigue crack with different lengths required so much effort, wire-cut cracked samples were used to determine critical stress intensity factor. Finite element analysis was also performed on one-quarter of the specimen using both the singular Borsum elements and the regular isoparametric elements to further investigate fracture toughness of the samples. It was observed that the singular elements presented better results than the isoparametric ones. A slight difference was also found between the results obtained from finite element method using singular elements and the experimental results.
2017-01-01
Idiopathic chronic inflammatory conditions (ICIC) such as allergy, asthma, chronic obstructive pulmonary disease, and various autoimmune conditions are a worldwide health problem. Understanding the pathogenesis of ICIC is essential for their successful therapy and prevention. However, efforts are hindered by the lack of comprehensive understanding of the human immune system function. In line with those efforts, described here is a concept of stochastic continuous dual resetting (CDR) of the immune repertoire as a basic principle that governs the function of immunity. The CDR functions as a consequence of system's thermodynamically determined intrinsic tendency to acquire new states of inner equilibrium and equilibrium against the environment. Consequently, immune repertoire undergoes continuous dual (two-way) resetting: against the physiologic continuous changes of self and against the continuously changing environment. The CDR-based dynamic concept of immunity describes mechanisms of self-regulation, tolerance, and immunosenescence, and emphasizes the significance of immune system's compartmentalization in the pathogenesis of ICIC. The CDR concept's relative simplicity and concomitantly documented congruency with empirical, clinical, and experimental data suggest it may represent a plausible theoretical framework to better understand the human immune system function. PMID:28246613
Silvana Balzar
2017-01-01
Full Text Available Idiopathic chronic inflammatory conditions (ICIC such as allergy, asthma, chronic obstructive pulmonary disease, and various autoimmune conditions are a worldwide health problem. Understanding the pathogenesis of ICIC is essential for their successful therapy and prevention. However, efforts are hindered by the lack of comprehensive understanding of the human immune system function. In line with those efforts, described here is a concept of stochastic continuous dual resetting (CDR of the immune repertoire as a basic principle that governs the function of immunity. The CDR functions as a consequence of system’s thermodynamically determined intrinsic tendency to acquire new states of inner equilibrium and equilibrium against the environment. Consequently, immune repertoire undergoes continuous dual (two-way resetting: against the physiologic continuous changes of self and against the continuously changing environment. The CDR-based dynamic concept of immunity describes mechanisms of self-regulation, tolerance, and immunosenescence, and emphasizes the significance of immune system’s compartmentalization in the pathogenesis of ICIC. The CDR concept’s relative simplicity and concomitantly documented congruency with empirical, clinical, and experimental data suggest it may represent a plausible theoretical framework to better understand the human immune system function.
Terkildsen, Søren; Svendsen, Svend
2012-01-01
The control strategy for mechanical ventilation systems has significant impact on the performance of the system, in terms of energy consumption and correct air distribution. This paper presents a static pressure reset control system employing a new type of flow damper with lower pressure loss...... for use in low pressure ventilation systems. The flow damper has a droplet shape that minimizes turbulence generation and the resulting pressure loss. The performance of the damper was examined by making measurements of pressure loss and airflow. These were used to determine the required pressure loss...... for operation and the airflow accuracy. Results were compared to similar tests carried out with conventional flat plate dampers. A static pressure reset control algorithm was programmed and analyzed on a test system consisting of three dampers, representing three office rooms. The comparison of the dampers...
Stochastic Phase Resetting: A Theory for Deep Brain Stimulation
Tass, P. A.
The basic principles of a stochastic approach to phase resetting in populations of interacting phase oscillators are presented in this article. This theory explains how synchronization and desynchronization processes are caused by a pulsatile stimulus. It is a central goal of this approach to establish a theoretical basis for the design of efficient and intelligent new deep brain stimulation techniques. Accordingly, the theory is used to design a new deep brain stimulation technique with feedback control in patients suffering from Parkinson's disease or essential tremor.
ON PRICING MODEL OF THE RESET OPTION WITH N PREDETERMINED LEVELS
JIANG Lishang; YANG Desheng; ZHANG Shuguang
2004-01-01
Motivated by the reset option with n predetermined dates analyzed by W.Cheng, we consider a kind of reset option with uncertain dates by introducing N pre-specified barrier levelsWe claim this reset option consists of some standard knock-in andknock-out barrier optionsThe closed-form pricing formula is derived by means of a PDE'sapproach.
Santos, Calink Indiara do Livramento; Carvalho, Melissa Souza; Raphael, Ellen; Ferrari, Jefferson Luis; Schiavon, Marco Antonio, E-mail: schiavon@ufsj.edu.br [Universidade Federal de Sao Joao del-Rei (UFSJ), MG (Brazil). Grupo de Pesquisa em Quimica de Materiais; Dantas, Clecio [Universidade Estadual do Maranhao (LQCINMETRIA/UEMA), Caxias, MA (Brazil). Lab. de Quimica Computacional Inorganica e Quimiometria
2016-11-15
In this work a colloidal approach to synthesize water-soluble CdSe quantum dots (QDs) bearing a surface ligand, such as thioglycolic acid (TGA), 3-mercaptopropionic acid (MPA), glutathione (GSH), or thioglycerol (TGH) was applied. The synthesized material was characterized by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), UV-visible spectroscopy (UV-Vis), and fluorescence spectroscopy (PL). Additionally, a comparative study of the optical properties of different CdSe QDs was performed, demonstrating how the surface ligand affected crystal growth. The particles sizes were calculated from a polynomial function that correlates the particle size with the maximum fluorescence position. Curve resolution methods (EFA and MCR-ALS) were employed to decompose a series of fluorescence spectra to investigate the CdSe QDs size distribution and determine the number of fraction with different particle size. The results for the MPA-capped CdSe sample showed only two main fraction with different particle sizes with maximum emission at 642 and 686 nm. The calculated diameters from these maximum emission were, respectively, 2.74 and 3.05 nm. (author)
Ehlers, F. J. H.; Seydou, M.; Tingaud, D.; Maurel, F.; Charles, Y.; Queyreau, S.
2016-12-01
We have performed a uniaxial tensile test on the Σ5 [1 0 0] 36.87° twist grain boundary (GB) in face-centred cubic Al within the framework of density functional theory in order to derive an atomistic cohesive traction-separation law. Addressing the importance of kinetics to GB breakage, we accompanied our energy-separation curve calculations by two additional studies. Firstly, using the nudged elastic band method, we determined for a series of GB separations the heights of the zero temperature barriers separating intact and broken GB configurations. Secondly, a representative subset of these transition paths was examined at finite temperature with ab initio molecular dynamics. Contrasting prevalent conclusions on GB breakage behaviour, our results suggest that the GB likely stays intact at room temperature well into the range of separations where a broken GB represents the thermodynamically favourable configuration. Given the non-negligible resulting influence on critical tensile stress and work of separation, our findings may be viewed as stressing the need for a kinetic analysis in a general first principles based uniaxial tensile test.
Fanjat, G.; Camps, P.; Alva Valdivia, L. M.; Sougrati, M. T.; Cuevas-Garcia, M.; Perrin, M.
2013-02-01
We present archeointensity data carried out on pieces of incense burners from the ancient Maya city of Palenque, Chiapas, Mexico, covering much of the Mesoamerican Classic period, from A.D. 400 to A.D. 850. We worked on pieces from 24 incense burners encompassing the five Classic ceramic phases of Palenque: Motiepa (A.D. 400-500), Cascadas (A.D. 500-600), Otulum (A.D. 600-700), Murcielagos (A.D. 700-770), and Balunté (A.D. 770-850). All the samples come from highly elaborate, flanged pedestal of incense burners that are undoubtedly assigned to a ceramic phase by means of their iconographic, morphological and stylistic analyses. Archeointensity measurements were performed with the Thellier-Thellier's method on pre-selected samples by means of their magnetic properties. We obtained archeointensities of very good technical quality from 19 of 24 pieces, allowing the determination of a precise mean value for each ceramic phase, between 29.1±0.9 μT and 32.5±1.2 μT. The firing temperatures of ceramics were estimated with Mössbauer spectroscopy between 700 °C and 1000 °C. These values ensure that a full thermo-remanent magnetization was acquired during the original heating. Our results suggest a relative stability of the field intensity during more than 400 years in this area. The abundance of archeological material in Mesoamerica contrasts with the small amount of archeomagnetic data available that are, in addition, of uneven quality. Thus, it is not possible to establish a trend of intensity variations in Mesoamerica, even using the global databases and secular variation predictions from global models. In this context, our high technical quality data represent a strong constraint for the Mesoamerican secular variation curve during the first millennium AD. The corresponding Virtual Axial Dipole Moments (VADM) are substantially smaller than the ones predicted by the last global geomagnetic models CALS3k.4, suggesting the need for additional data to develop a
Ronny Pini; Sally M Benson
2013-01-01
Capillary pressure and relative permeability drainage curves are simultaneously measured on a single Berea Sandstone core by using three different fluid pairs, namely g CO 2/water, g N 2/water and s c CO 2/brine...
Pires, Luiz F.; Bacchi, Osny O. S. [Centro de Energia Nuclear na Agricultura (CENA), Piracicaba, SP (Brazil)
2002-07-01
The soil water retention curve relates the soil water matric potential ({psi}{sub m}) and the soil moisture ({theta}). When no significant changes occur in soil structure, the water retention curve can be considered as a soil physical characteristic. This article presents a new procedure for soil water retention curve evaluation using gamma-ray beam attenuation as an auxiliary technique for soil moisture determination. The radioactive source used in the experiment was {sup 241} Am, and the detector was a 3 in. x 3 in. NaI(Tl) scintillation crystal coupled to a photomultiplier tube. The proposed procedure avoids the need of frequent sample manipulation as in the case of the conventional method. The soil moisture can be continuously monitored inside the chamber allowing a more precise judgment of the equilibrium. The time required for the retention curve determination can be significantly reduced in comparison with the traditional method. The results obtained show that the new procedure presents many advantages in relation to the traditional method and that it can be routinely used for soil water retention curve determination. (author)
Ping Wan
2016-08-01
Full Text Available Driving anger, called “road rage”, has become increasingly common nowadays, affecting road safety. A few researches focused on how to identify driving anger, however, there is still a gap in driving anger grading, especially in real traffic environment, which is beneficial to take corresponding intervening measures according to different anger intensity. This study proposes a method for discriminating driving anger states with different intensity based on Electroencephalogram (EEG spectral features. First, thirty drivers were recruited to conduct on-road experiments on a busy route in Wuhan, China where anger could be inducted by various road events, e.g., vehicles weaving/cutting in line, jaywalking/cyclist crossing, traffic congestion and waiting red light if they want to complete the experiments ahead of basic time for extra paid. Subsequently, significance analysis was used to select relative energy spectrum of β band (β% and relative energy spectrum of θ band (θ% for discriminating the different driving anger states. Finally, according to receiver operating characteristic (ROC curve analysis, the optimal thresholds (best cut-off points of β% and θ% for identifying none anger state (i.e., neutral were determined to be 0.2183 ≤ θ% < 1, 0 < β% < 0.2586; low anger state is 0.1539 ≤ θ% < 0.2183, 0.2586 ≤ β% < 0.3269; moderate anger state is 0.1216 ≤ θ% < 0.1539, 0.3269 ≤ β% < 0.3674; high anger state is 0 < θ% < 0.1216, 0.3674 ≤ β% < 1. Moreover, the discrimination performances of verification indicate that, the overall accuracy (Acc of the optimal thresholds of β% for discriminating the four driving anger states is 80.21%, while 75.20% for that of θ%. The results can provide theoretical foundation for developing driving anger detection or warning devices based on the relevant optimal thresholds.
Cardiac Resynchronization Therapy and phase resetting of the sinoatrial node: A conjecture
Cantini, Federico; Varanini, Maurizio; Macerata, Alberto; Piacenti, Marcello; Morales, Maria-Aurora; Balocchi, Rita
2007-03-01
through the use of models and physical considerations. We first used the data of literature on far-field effects of cardiac defibrillators to prove that the pacemaker impulses delivered to the two ventricles were able to induce modifications in membrane voltage at the level of the SA node. To simulate a phase resetting mechanism of the SA node, we used a Van der Pol modified model to allow the possibility of changing the refractory period and the firing frequency of the cells separately. With appropriate parameters of the model we reproduced phase response curves that can account for our experimental data. Furthermore, the simulated curves closely resemble the functional form proposed in literature for perturbed aggregate of cardiac cells. Despite the small sample of subjects investigated and the limited number of ECG recordings at different AV delays, we think we have proved the plausibility of the proposed conjecture.
Cardiac resynchronization therapy and phase resetting of the sinoatrial node: a conjecture.
Cantini, Federico; Varanini, Maurizio; Macerata, Alberto; Piacenti, Marcello; Morales, Maria-Aurora; Balocchi, Rita
2007-03-01
through the use of models and physical considerations. We first used the data of literature on far-field effects of cardiac defibrillators to prove that the pacemaker impulses delivered to the two ventricles were able to induce modifications in membrane voltage at the level of the SA node. To simulate a phase resetting mechanism of the SA node, we used a Van der Pol modified model to allow the possibility of changing the refractory period and the firing frequency of the cells separately. With appropriate parameters of the model we reproduced phase response curves that can account for our experimental data. Furthermore, the simulated curves closely resemble the functional form proposed in literature for perturbed aggregate of cardiac cells. Despite the small sample of subjects investigated and the limited number of ECG recordings at different AV delays, we think we have proved the plausibility of the proposed conjecture.
Pressing reset on Moscow is worth a little Nato anxiety / Jonathan Steele
Steele, Jonathan
2009-01-01
USA president Barack Obama on avaldanud soovi vajutada USA-Vene suhetes reset-nuppu. Eesti president Toomas Hendrik Ilves ütles NATO tippkohtumise eelõhtul kuivalt, et arvutil reset-nuppu vajutades ei kustu mällu salvestatud failid siiski ära. President T. H. Ilvese teravast sõnavõtust president Lennart Meri konverentsi avamisel Tallinnas
Pressing reset on Moscow is worth a little Nato anxiety / Jonathan Steele
Steele, Jonathan
2009-01-01
USA president Barack Obama on avaldanud soovi vajutada USA-Vene suhetes reset-nuppu. Eesti president Toomas Hendrik Ilves ütles NATO tippkohtumise eelõhtul kuivalt, et arvutil reset-nuppu vajutades ei kustu mällu salvestatud failid siiski ära. President T. H. Ilvese teravast sõnavõtust president Lennart Meri konverentsi avamisel Tallinnas
Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation
Madsen, P L; Hasselbalch, S G; Hagemann, L P;
1995-01-01
fraction of the activation-induced excess glucose uptake. These data confirm earlier reports that brain activation can induce resetting of the cerebral oxygen/glucose consumption ratio, and indicate that the resetting persists for a long period after cerebral activation has been terminated and physiologic...
Meng, Yi; Yi, Weijian
2011-06-01
Polyvinylidene fluoride (PVDF) piezoelectric material has been successfully applied in many engineering fields and scientific research. However, it has rarely been used for direct measurement of concrete stresses under impact loading. In this paper, a new PVDF-based stress gauge was developed to measure concrete stresses under impact loading. Calibrated on a split Hopkinson pressure bar (SHPB) with a simple measurement circuit of resistance strain gauges, the PVDF gauge was then used to establish dynamic stress-strain curves of concrete cylinders from a series of axial impact testing on a drop-hammer test facility. Test results show that the stress curves measured by the PVDF-based stress gauges are more stable and cleaner than that of the stress curves calculated with the impact force measured from a load cell.
Diffusion with stochastic resetting at power-law times
Nagar, Apoorva; Gupta, Shamik
2016-06-01
What happens when a continuously evolving stochastic process is interrupted with large changes at random intervals τ distributed as a power law ˜τ-(1 +α );α >0 ? Modeling the stochastic process by diffusion and the large changes as abrupt resets to the initial condition, we obtain exact closed-form expressions for both static and dynamic quantities, while accounting for strong correlations implied by a power law. Our results show that the resulting dynamics exhibits a spectrum of rich long-time behavior, from an ever-spreading spatial distribution for α 1 . The dynamics has strong consequences on the time to reach a distant target for the first time; we specifically show that there exists an optimal α that minimizes the mean time to reach the target, thereby offering a step towards a viable strategy to locate targets in a crowded environment.
Investigating the resetting of OSL signals in rock surfaces
Sohbati, Reza; Murray, Andrew S.; Jain, Mayank
2011-01-01
There are many examples of buried rock surfaces whose age is of interest to geologists and archaeologists. Luminescence dating is a potential method which can be applied to dating such surfaces; as part of a research project which aims to develop such an approach, the degree of resetting of OSL...... signals in grains and slices from five different cobbles/boulders collected from a modern beach is investigated. All the rock surfaces are presumed to have been exposed to daylight for a prolonged period of time (weeks to years). Feldspar was identified as the preferred dosimeter because quartz extracts...... were insensitive. Dose recovery tests using solar simulator and IR diodes on both K-feldspar grains and solid slices taken from the inner parts of the rocks are discussed. Preheat plateau results using surface grains and slices show that significant thermal transfer in naturally bleached samples can...
Type Directed Partial Evaluation for Level-1 Shift and Reset
Danko Ilik
2013-09-01
Full Text Available We present an implementation in the Coq proof assistant of type directed partial evaluation (TDPE algorithms for call-by-name and call-by-value versions of shift and reset delimited control operators, and in presence of strong sum types. We prove that the algorithm transforms well-typed programs to ones in normal form. These normal forms can not always be arrived at using the so far known equational theories. The typing system does not allow answer-type modification for function types and allows delimiters to be set on at most one atomic type. The semantic domain for evaluation is expressed in Constructive Type Theory as a dependently typed monadic structure combining Kripke models and continuation passing style translations.
Vittitoe, C.N.
1993-08-01
A method is presented to unfold the two-dimensional vertical structure in electron density by using data on the total electron content for a series of paths through the ionosphere. The method uses a set of orthonormal basis functions to represent the vertical structure and takes advantage of curved paths and the eikonical equation to reduce the number of iterations required for a solution. Curved paths allow a more thorough probing of the ionosphere with a given set of transmitter and receiver positions. The approach can be directly extended to more complex geometries.
K.R. Arpin; T.F. Trimble
2003-04-01
This testing was undertaken to develop material true stress-true strain curves for elastic-plastic material behavior for use in performing transient analysis. Based on the conclusions of this test, the true stress-true strain curves derived herein are valid for use in elastic-plastic finite element analysis for structures fabricated from these materials. In addition, for the materials tested herein, the ultimate strain values are greater than those values cited as the limits for the elastic-plastic strain acceptance criteria for transient analysis.
Ying Li; Gaoyang Zhao; Jian Su; Erfeng Shen; Yang Ren
2014-05-01
We have fabricated ZrO2 thin films by sol–gel deposition and annealed them at 300, 500 and 700 °C. Reproducible - curves can be obtained for the device Cu/ZrO2/ATO which is measured at room temperature (300 K). During the RESET operation, L and H values can be controlled by the RESET voltage. Moreover, the Cu/ZrO2/ATO device which the ZrO2 thin film annealed at 300 °C can be measured as resistive switching sweeps at 200, 100 and 50 K. It was found that the ratio of off/on reduced when the measured temperature decreased. When the - measurement temperature decreases, on decreases obviously which is typical for electronic transportation in a Cu metal. It is indicated that the Cu metallic conduction filament has been formed in the ZrO2 films. Besides, the microstructure by high resolution transmission electrical microscopy (HRTEM) was also investigated.
无
2002-01-01
Adsorption isotherm is the most fundamental information related to chromatography. To calculate the parameters of Langmuir adsorption isotherm of thymidine, frontal analysis (FA) and elution-curve method (ECM) were adopted in reversed-phase high performance liguid chromatography (RP-HPLC). In FA, the concentration of stationary phase was measured from the elution curves and the isotherm was determined by regression analysis, while the parameters by ECM were obtained by parameter optimization. The adsorption isotherms of thymidine from the two methods were very similar. The superiority of ECM over FA was that the consumption of sample was less and only one or two injections of sample were required.
Sata, Yusuke; Kawada, Toru; Shimizu, Shuji; Kamiya, Atsunori; Akiyama, Tsuyoshi; Sugimachi, Masaru
2015-01-01
There is ongoing controversy over whether neural or peripheral factors are the predominant cause of hypertension. The closed-loop negative feedback operation of the arterial baroreflex hampers understanding of how arterial pressure (AP) is determined through the interaction between neural and peripheral factors. METHODS AND RESULTS: A novel analysis of an isolated open-loop baroreceptor preparation to examine sympathetic nervous activity (SNA) and AP responses to changes in carotid sinus pressure (CSP) in adult spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY) was conducted. In the neural arc (CSP-SNA relationship), the midpoint pressure (128.9±3.8 vs. 157.9±8.1 mmHg, P<0.001) and the response range of SNA to CSP (90.5±3.7 vs. 115.4±7.6%/mmHg, P=0.011) were higher in SHR. In the peripheral arc (SNA-AP relationship), slope and intercept did not differ. A baroreflex equilibrium diagram was obtained by depicting neural and peripheral arcs in a pressure-SNA plane with rescaled SNA (% in WKY). The operating-point AP (111.3±4.4 vs. 145.9±5.2 mmHg, P<0.001) and SNA (90.8±3.2 vs. 125.1±6.9% in WKY, P<0.001) were shifted towards a higher level in SHR. The shift of the neural arc towards a higher SNA range indicated a predominant contribution to baroreflex resetting in SHR. Notwithstanding the resetting, the carotid sinus baroreflex in SHR preserved an ability to reduce AP if activated with a high enough pressure.
Christian Hauptmann
2015-01-01
Full Text Available Purpose. Primary tinnitus has a severe negative influence on the quality of life of a significant portion of the general population. Acoustic coordinated reset neuromodulation is designed to induce a long-lasting reduction of tinnitus symptoms. To test acoustic coordinated reset neuromodulation as a treatment for chronic, tonal tinnitus under real life conditions, an outpatient study “RESET Real Life” was commissioned by ANM GmbH. Herein we present the results of this study. Methods. In a prospective, open-label, nonrandomized, noncontrolled multicenter clinical study with 200 chronic tinnitus patients, tinnitus questionnaire TBF-12 and Global Clinical Improvement-Impression Scale (CGI-I7 are used to study the safety and efficacy of acoustic coordinated reset neuromodulation. 189 patients completed the last 12-month visit, 11 patients dropped out (8 because of nontreatment related reasons; 2 because tinnitus did not change; and 1 because tinnitus got louder. Results. Acoustic coordinated reset neuromodulation caused a statistically and clinically significant decrease in TBF-12 scores as well as in CGI-I7 after 12 months of therapy under real life conditions. There were no persistent adverse events reported that were related to the therapy. Conclusion. The field study “RESET Real Life” provides evidence for safety and efficacy of acoustic coordinated reset neuromodulation in a prospective, open-label, real life setting.
Voice Biometrics as a Way to Self-service Password Reset
Hohgräfe, Bernd; Jacobi, Sebastian
Password resets are time consuming. Especially when urgent jobs need to be done, it is cumbersome to inform the user helpdesk, to identify oneself and then to wait for response. It is easy to enter a wrong password multiple times, which leads to the blocking of the application. Voice biometrics is an easy and secure way for individuals to reset their own password. Read more about how you can ease the burden of your user helpdesk and how voice biometric password resets benefit your expense situation without harming your security.
Exponential stability of a PI plus reset integrator controller by a sampled-data system approach
Davó, M. A.; Gouaisbaut, F.; Baños, A; Tarbouriech, S.; Seuret, A.
2016-01-01
The paper deals with the stability analysis of time-delay reset control systems, for which the resetting law is assumed to satisfy a time-dependent condition. A stability analysis of the closed-loop system is performed based on an appropriate sampled-data system. New linear matrix inequality (LMI) conditions are proposed to ensure the exponential stability of the closed-loop resulting of the connection of a plant with a proportional and integral controller together with a reset integrator (PI...
Determination of the cascade-curve maximum depth from the muon component on the Yakutsk EAS array
Glushkov, A. V., E-mail: a.v.glushkov@ikfia.ysn.ru; Saburov, A. V. [Russian Academy of Sciences, Shafer Institute of Space Physics and Aeronomy, Yakutsk Research Center, Siberian Branch (Russian Federation)
2014-11-15
The lateral distribution of muons with a threshold E{sub µ} secθ GeV in extensive air showers with E{sub 0} ≥ 10{sup 17} eV over the period of observations on the Yakutsk array from November 2011 to June 2013 has been investigated. It follows from this distribution that the cascade-curve maximum depth X{sub m} in the energy range (1–5) × 10{sup 17} eV increases relatively rapidly, because the cosmic-ray composition changes from iron nuclei dominating at E{sub 0} ≈ 10{sup 17} eV to protons.
刘俏; 刘立昕; 金子豪; 赵明举; 齐小辉
2013-01-01
反应器停留时间分布的确定是建立反应器流动模型的基础。本文介绍了用 MATLAB 的 Curve Fitting Toolbox 计算反应器停留时间分布的方法。通过在图形界面下导入数据及平滑处理、采用平滑样条拟合数据以及数值积分等操作，确定了反应器停留时间分布的特征值，并且以确定系数 R2、误差平方和以及均方根误差评价拟合模型的精确度。研究表明：计算结果与文献相吻合。该法运行可靠，无需编程、易于掌握。与传统计算方法相比，操作更为便捷，强有力的图形界面也使计算变得更加简单而直观。% The residence time distribution (RTD) of a chemical reactor is a probability distribution function that describes the amount of time a fluid element could spend inside the reactor. Chemical engineers use the RTD to characterize the mixing and flow within reactors and to compare the behavior of real reactors to their ideal models. This is useful, not only for troubleshooting existing reactors, but in estimating the yield of a given reaction and designing future reactors. The determination of the RTD for a reactor is essential to the reactor flow model. This paper presents a new method to determine the RTD characteristics using MATLAB’s Curve Fitting Toolbox. The acquired data was imported and smoothed via the graphical user interface (GUI). Smoothing spline was used to produce smooth curves to fit to the data, and the RTD characteristics were calculated by numerical integrals. The root-mean-square error (RMSE), error sum of squares (SSE), and determination coefficient (R2) statistics were used to evaluate the model’s accuracy. The study showed that the calculated results are accurate and reliable because they are consistent with those in the literatures. Compared with the traditional calculations, this method provides visualized results, and the GUI simplifies the calculation and makes it intuitive. It can be
Optimal number of stimulation contacts for coordinated reset neuromodulation
Borys eLysyansky
2013-07-01
Full Text Available In this computational study we investigatecoordinated reset (CR neuromodulation designed for an effective controlof synchronization by multi-site stimulation of neuronal target populations. This method was suggested to effectively counteract pathological neuronal synchronycharacteristic for several neurological disorders. We studyhow many stimulation sites are required for optimal CR-induced desynchronization. We found that a moderate increase of the number of stimulation sitesmay significantly prolong the post-stimulation desynchronized transientafter the stimulation is completely switched off. This can, in turn,reduce the amount of the administered stimulation current for theintermittent ON-OFF CR stimulation protocol, where time intervalswith stimulation ON are recurrently followed by time intervals withstimulation OFF. In addition, we found that the optimal number ofstimulation sites essentially depends on how strongly the administeredcurrent decays within the neuronal tissue with increasing distancefrom the stimulation site. In particular, for a broad spatial stimulationprofile, i.e., for a weak spatial decay rate of the stimulation current,CR stimulation can optimally be delivered via a small number of stimulationsites. Our findings may contribute to an optimization of therapeutic applications of CR neuromodulation.
LORETA EEG phase reset of the default mode network.
Thatcher, Robert W; North, Duane M; Biver, Carl J
2014-01-01
The purpose of this study was to explore phase reset of 3-dimensional current sources in Brodmann areas located in the human default mode network (DMN) using Low Resolution Electromagnetic Tomography (LORETA) of the human electroencephalogram (EEG). The EEG was recorded from 19 scalp locations from 70 healthy normal subjects ranging in age from 13 to 20 years. A time point by time point computation of LORETA current sources were computed for 14 Brodmann areas comprising the DMN in the delta frequency band. The Hilbert transform of the LORETA time series was used to compute the instantaneous phase differences between all pairs of Brodmann areas. Phase shift and lock durations were calculated based on the 1st and 2nd derivatives of the time series of phase differences. Phase shift duration exhibited three discrete modes at approximately: (1) 25 ms, (2) 50 ms, and (3) 65 ms. Phase lock duration present primarily at: (1) 300-350 ms and (2) 350-450 ms. Phase shift and lock durations were inversely related and exhibited an exponential change with distance between Brodmann areas. The results are explained by local neural packing density of network hubs and an exponential decrease in connections with distance from a hub. The results are consistent with a discrete temporal model of brain function where anatomical hubs behave like a "shutter" that opens and closes at specific durations as nodes of a network giving rise to temporarily phase locked clusters of neurons for specific durations.
Hurtado, Fernando S.V.; Maliska, Clovis R.; Silva, Antonio F.C. da; Ambrus, Jaime; Contessi, Bruno A.; Cordazzo, Jonas [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil). Dept. de Engenharia Mecanica. Lab. de Simulacao Numerica em Mecanica dos Fluidos e Transferencia de Calor (SINMEC)
2004-07-01
It is unquestionable the significant role that reservoir simulation has gained in the petroleum industry today. Nevertheless, the accuracy of this prediction toll is frequently degraded not only by inherent uncertainty in the reservoir characterization, but also by usually deficient estimation of relative permeability curves, which are the key elements for macroscopic description of multiphase flow in porous media. In practice, these flow functions should be estimated from data collected in displacement experiments. Although numerous methods for estimating relative permeabilities from these experimental data have been developed over the years, their practical application have been suffered from many problems mainly arisen on the oversimplified mathematical models on which those methods were based. In recent years, parameter estimation techniques are being increasingly applied to estimate relative permeabilities, mostly because they allow employing a flow model as accurate as necessary to represent all influencing factors on the fluid displacement. The present work describes the main characteristics and potentialities of an application software developed as a supporting toll for the task of estimation of reliable relative permeability curves by a parameter estimation method. Special emphasis was given to the implementation of a numerical flow model including relevant physical factors, such as rock heterogeneity, capillary pressure, gravity effects, and fluid compressibility. (author)
Banner, W; Kahn, C M
2014-02-01
CONTEXT. Recent publications have graphically demonstrated a curvilinear relationship between measures of intelligence and blood lead levels at low concentrations (dose-response curves. METHODS. Random data based on varied distributions were constructed to simulate a previous study using a single, randomly generated covariate income (Inc) to demonstrate the impact of normally versus exponentially distributed data on the shape of the graph of intelligence quotient (IQ) versus blood lead. We also used an existing database of US blood lead levels and constructed a similar model of income and IQ using both assumptions of distribution for the intermediate variable income. RESULTS. When both lead and income are exponentially distributed, the graph of lead and IQ will be a curve. CONCLUSION. The apparent shape of a dose-response relationship from simulated epidemiological data is nonlinear when one variable and a covariate are exponentially distributed. A non-linear biological relationship should not be assumed and in fact may be the least likely explanation. The use of observational epidemiological data to discern a dose-response relationship between two variables may be misleading.
Firmino, Sandro F.; Souza, Wedla P. de; Hoff, Gabriela, E-mail: sandro.frmino@pucrs.b, E-mail: wedla.souza@acad.pucrs.b, E-mail: ghoff@pucrs.b [Pontificia Universidade Catolica do Rio Grande do Sul (PUC-RS), Porto Alegre, RS (Brazil). Fac. de Fisica. Grupo de Experimentacao e Simulacao Computacional em Fisica Medica (GESiC); Vilhena, Marco T., E-mail: vilhena@pq.cnpq.b [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Programa de Pos-Graduacao em Engenharia Mecanica
2009-07-01
The transmission of photons is an important parameter used to calculate the shielding material thickness. The method of computational simulation purposed, in this work, was applied to generate transmission curves for different energies for monoenergetic beams, on diagnostic radiology energy range, for values between 60 and 150 keV, in steps of 10 keV; and polienergetics spectra for accelerating tube tensions of 140 kVp and 150 kVp. The polienergetic spectra were selected from the Catalogue of Diagnostic X-Ray Spectra and Other Data [1] and changed using deterministic methods to add Aluminum filtration of 3.0 mm. The main objective of this work was to verify the sensitivity of photons spectra to differences observed on barite mortar composition. The computational universe generated simulates photon spectra irradiating directly a shielding wall. The different barite mortar compositions were defined base on a unique sample analysed using the energy dispersion spectroscopy (EDS) measurements in a Philips XL 30 Scanning Electron Microscope (SEM). The compositions were realized on four different areas of one sample: one on opened field of view and the three others uses focused field of view. It was possible verify differences on transmission curves for the different studied energies and different compositions of barite mortar. We suggest future works to study realistic spectra for different barite mortar compositions commercialized in Brazil. (author)
Atom Probe Insights into U-Pb Age Resetting in Baddeleyite
White, L. F.; Reinhard, D.; Moser, D.; Darling, J. R.; Bullen, D.; Prosa, T. J.; Olson, D.; Larson, D. J.; Clifton, P. H.; Lawrence, D.; Martin, I.
2016-08-01
Atom probe analysis of highly shocked baddeleyite suggests that igneous crystallisation ages can be isolated from 'partially reset' grains through careful segregation and rejection of planar features known to induce post-impact Pb-diffusion.
Reduction of RESET current in phase change memory devices by carbon doping in GeSbTe films
Park, J. H.; Kim, S.-W.; Kim, J. H.; Wu, Z.; Cho, S. L.; Ahn, D.; Ahn, D. H.; Lee, J. M.; Nam, S. U.; Ko, D.-H.
2015-03-01
Phase Change Memory (PCM) has been proposed for use as a substitute for flash memory to satisfy the huge demands for high performance and reliability that promise to come in the next generation. In spite of its high scalability, reliability, and simple structure, high writing current, e.g., RESET current, has been a significant obstacle to achieving a high density in storage applications and the low power consumption required for use in mobile applications. We report herein on an attempt to determine the level of carbon incorporated into a GeSbTe (GST) film that is needed to reduce the RESET current of PCM devices. The crystal structure of the film was transformed into an amorphous phase by carbon doping, the stability of which was enhanced with increasing carbon content. This was verified by the small grain size and large band gap that are typically associated with carbon. The increased level of C-Ge covalent bonding is responsible for these enhancements. Thus, the resistance of the carbon doped Ge2Sb2Te5 film was higher than that for an undoped GST film by a factor of 2 orders of magnitude after producing a stable face-centered cubic phase by annealing. As a consequence, the PCM devices showed a significant reduction in RESET current as low as 23% when the carbon content was increased to 11.8 at. %. This can be attributed to the elevated SET resistance, which is proportional to the dynamic resistance of the PCM device, caused by the high resistance due to a carbon doped GST film.
Lemoine, X.; Iancu, A.; Ferron, G.
2011-05-01
Nowadays, an accurate determination of the true stress-strain curve is a key-element for all finite element (FE) forming predictions. Since the introduction of Advanced High Strength Steels (AHSS) for the automotive market, the standard uniaxial tension test suffers the drawback of relatively low uniform elongations. The extrapolation of the uniaxial stress-strain curve up to large strains is not without consequence in forming predictions—especially formability and springback. One of the means to solve this problem is to use experimental tests where large plastic strain levels can be reached. The hydraulic bulge test is one of these tests. The effective plastic strain levels reached in the bulge test are of about 0.7. From an experimental standpoint, the biaxial flow stress is estimated using measurement of fluid pressure, and calculation of thickness and curvature at the pole, via appropriate measurements and assumptions. The biaxial stress at the pole is determined using the membrane equilibrium equation. The analysis proposed in this paper consists of performing "virtual experiments" where the results obtained by means of FE calculations are used as input data for determining the biaxial stress-strain law in agreement with the experimental procedure. In this way, a critical discussion of the experimental procedure can be made, by comparing the "experimental" stress-strain curve (Membrane theory curve) with the "reference" one introduced in the simulations. In particular, the influences of the "(die diameter)/thickness" ratio and of the plastic anisotropy are studied, and limitations of the hydraulic bulge test analysis are discussed.
Ubelaker, D H; Buchholz, B A
2005-04-26
Atmospheric testing of nuclear weapons during the 1950s and early 1960s doubled the level of radiocarbon ({sup 14}C) in the atmosphere. From the peak in 1963, the level of {sup 14}CO{sub 2} has decreased exponentially with a mean life of about 16 years, not due to radioactive decay, but due to mixing with large marine and terrestrial carbon reservoirs. Since radiocarbon is incorporated into all living things, the bomb-pulse is an isotopic chronometer of the past half century. The absence of bomb radiocarbon in skeletonized human remains generally indicates a date of death before 1950. Comparison of the radiocarbon values with the post 1950 bomb-curve may also help elucidate when in the post 1950 era, the individual was still alive. Such interpretation however, must consider the age at death of the individual and the type of tissue sampled.
EEG PHASE RESET OF THE DEFAULT MODE NETWORK
Robert W. Thatcher
2014-07-01
Full Text Available Objectives: The purpose of this study was to explore phase reset of 3-dimensional current sources located in Brodmann areas located in the human default mode network (DMN using Low Resolution Electromagnetic Tomography (LORETA of the human electroencephalogram (EEG. Methods: The EEG was recorded from 19 scalp locations from 70 healthy normal subjects ranging in age from 13 to 20 years. A time point by time point computation of LORETA current sources were computed for 14 Brodman areas comprising the DMN in the delta frequency band. The Hilbert transform of the LORETA time series was used to compute the instantaneous phase differences between all pairs of Brodmann areas. Phase shift and lock durations were calculated based on the 1st & 2nd derivatives of the time series of phase differences. Results: Phase shift duration exhibited three discrete modes at approximately: 1- 30 msec,, 2- 55 msec and, 3- 65 msec. Phase lock duration present primarily at: 1- 300 to 350 msec and, 2- 350 msec to 450 msec. Phase shift and lock durations were inversely related and exhibited an exponential change with distance between Brodmann areas. Conclusions: The results are explained by local neural packing density of network hubs and an exponential decrease in connections with distance from a hub. The results are consistent with a discrete temporal model of brain function where anatomical hubs behave like a ‘shutter’ that opens and closes at specific durations as nodes of a network giving rise to temporarily phase locked clusters of neurons for specific durations.
Horovitz, Amnon; Levitzki, Alexander
1987-10-01
Receptor-ligand dissociation constants are usually calculated from the displacement curve of a radioactively labeled ligand bound to the receptor. The formula used is restricted to cases in which the concentration of receptor is negligible compared to the concentration of both the displacing ligand and the radioactive ligand used. In this study, we rigorously derive a simple equation that can be used for calculating receptor-ligand dissociation constants for any set of experimental conditions. A linearized form of this equation provides a convenient plot from which the dissociation constant of the displacing ligand can be directly obtained. The plot is also a test for the competitive mode of binding. This exact equation now allows us to estimate the error incurred by the conventionally used equations. Similarly, we show that for competitive inhibition in enzymology, one can derive the analogous formula. Our new formula is free of the usual restrictions--namely, that the enzyme concentration is very small compared to the concentration of both the substrate and the inhibitor. It may therefore be applied to any set of experimental conditions.
Kundin, Julia; Choudhary, Muhammad Ajmal
2016-07-01
The phase-field crystal (PFC) technique is a widely used approach for modeling crystal growth phenomena with atomistic resolution on mesoscopic time scales. We use a two-dimensional PFC model for a binary system based on the work of Elder et al. [Phys. Rev. B 75, 064107 (2007)PRBMDO1098-012110.1103/PhysRevB.75.064107] to study the effect of the curved, diffuse solid-liquid interface on the interfacial energy as well as the nucleation barrier. The calculation of the interfacial energy and the nucleation barrier certainly depends on the proper definition of the solid-liquid dividing surface and the corresponding nucleus size. We define the position of the sharp interface at which the interfacial energy is to be evaluated by using the concept of equimolar dividing surface (r^{e}) and the minimization of the interfacial energy (r^{s}). The comparison of the results based on both radii shows that the difference r^{e}-r^{s} is always positive and has a limit for large cluster sizes which is comparable to the Tolman length. Furthermore, we found the real nucleation barrier for small cluster sizes, which is defined as a function of the radius r^{s}, and compared it with the classical nucleation theory. The simulation results also show that the extracted interfacial energy as function of both radii is independent of system size, and this dependence can be reasonably described by the nonclassical Tolman formula with a positive Tolman length.
Elena Phoka
2010-04-01
Full Text Available Cerebellar Purkinje cells display complex intrinsic dynamics. They fire spontaneously, exhibit bistability, and via mutual network interactions are involved in the generation of high frequency oscillations and travelling waves of activity. To probe the dynamical properties of Purkinje cells we measured their phase response curves (PRCs. PRCs quantify the change in spike phase caused by a stimulus as a function of its temporal position within the interspike interval, and are widely used to predict neuronal responses to more complex stimulus patterns. Significant variability in the interspike interval during spontaneous firing can lead to PRCs with a low signal-to-noise ratio, requiring averaging over thousands of trials. We show using electrophysiological experiments and simulations that the PRC calculated in the traditional way by sampling the interspike interval with brief current pulses is biased. We introduce a corrected approach for calculating PRCs which eliminates this bias. Using our new approach, we show that Purkinje cell PRCs change qualitatively depending on the firing frequency of the cell. At high firing rates, Purkinje cells exhibit single-peaked, or monophasic PRCs. Surprisingly, at low firing rates, Purkinje cell PRCs are largely independent of phase, resembling PRCs of ideal non-leaky integrate-and-fire neurons. These results indicate that Purkinje cells can act as perfect integrators at low firing rates, and that the integration mode of Purkinje cells depends on their firing rate.
Wong, Kai-Pun; Lang, Brian Hung-Hin; Lam, Shi; Au, Kin-Pan; Chan, Diane Toi-yin; Kotewall, Nicholas Clarence
2016-03-01
Transcutaneous laryngeal ultrasonography (TLUSG) is a promising alternative to laryngoscopy in vocal cords (VCs) assessment which might be challenging in the beginning. However, it remains unclear when an assessor can provide proficient TLUSG enough to abandon direct laryngoscopy . Eight surgical residents (SRs) without prior USG experience were recruited to determine the learning curve. After a standardized training program, SRs would perform 80 consecutive peri-operative VCs assessment using TLUSG. Performances of SRs were quantitatively evaluated by a composite performance score (lower score representing better performance) which comprised total examination time (in seconds), VCs visualization, and assessment accuracy. Cumulative sum (CUSUM) chart was then used to evaluate learning curve. Diagnostic accuracy and demographic data between every twentieth TLUSG were compared. 640 TLUSG examinations had been performed by 8 residents. 95.1% of VCs could be assessed by SRs. The CUSUM curve showed a rising pattern (learning phase) until 7th TLUSG and then flattened. The curve declined continuously after 42nd TLUSG (after reaching a plateau). Rates of assessable VCs were comparable in every twentieth cases performed. It took a longer time to complete TLUSG in 1st-20th than 21st-40th examinations. (45 vs. 32s, p = 0.001). Although statistically not significant, proportion of false-negative results was higher in 21st-40th (2.5%) than 1(st)-20th (0.6%), 41(st)-60th (0.7%), and 61(st)-80th (0.7%) TLUSG performed. After a short formal training, surgeons could master skill in TLUSG after seven examination and assess vocal cord function consistently and accurately after 40 TLUSG.
Chowdhury, Tamshuk; Sivaprasad, S.; Bar, H. N.; Tarafder, S.; Bandyopadhyay, N. R.
2016-04-01
Cyclic J-R behaviour of a reactor pressure vessel steel using different methods available in literature has been examined to identify the best suitable method for cyclic fracture problems. Crack opening point was determined by moving average method. The η factor was experimentally determined for cyclic loading conditions and found to be similar to that of ASTM value. Analyses showed that adopting a procedure analogous to the ASTM standard for monotonic fracture is reasonable for cyclic fracture problems, and makes the comparison to monotonic fracture results straightforward.
Wang, Guo-Qing; Sun, Wan-Ping; Zhu, Yong-Jin; Zou, Rong; Zhou, Xi-Ping
2006-07-01
Objective To investigate the role of H(1) and H(2) receptors in the locus ceruleus (LC) in carotid sinus baroreceptor reflex (CSR) resetting induced by intracerebroventricular (i.c.v.) injection of histamine (HA). Methods The left and right carotid sinus regions were isolated from the systemic circulation in 18 male Sprague-Dawley rats anesthetized with pentobarbital sodium. The intracarotid sinus pressure (ISP) was altered in a stepwise manner in vivo. ISP-mean arterial pressure (MAP) relationship curve and its characteristic parameters were constructed by fitting to the logistic function with five parameters. The changes in CSR performance induced by i.c.v. HA and the effects of pretreatment with H(1) or H(2) receptors selective antagonist, chlorpheniramine (CHL) or cimetidine (CIM) into the LC, on the responses of CSR to HA were examined. Results I.c.v. HA (100 ng in 5 mu l) significantly shifted the ISP-MAP relationship curve upwards (P 0.05). Conclusion Intracerebroventricular administration of HA results in a rapid resetting of CSR and a decrease in reflex sensitivity, and the responses of CSR to HA may be mediated, at least in part, by H(1) and H(2) receptors activities in the LC, especially by H(1) receptors. Moreover, the effects of the central HA on CSR might be related to a histaminergic descending pathway from the hypothalamus to LC.
Neural and Behavioral Evidence for an Online Resetting Process in Visual Working Memory.
Balaban, Halely; Luria, Roy
2017-02-01
Visual working memory (VWM) guides behavior by holding a set of active representations and modifying them according to changes in the environment. This updating process relies on a unique mapping between each VWM representation and an actual object in the environment. Here, we destroyed this mapping by either presenting a coherent object but then breaking it into independent parts or presenting an object but then abruptly replacing it with a different object. This allowed us to introduce the neural marker and behavioral consequence of an online resetting process in humans' VWM. Across seven experiments, we demonstrate that this resetting process involves abandoning the old VWM contents because they no longer correspond to the objects in the environment. Then, VWM encodes the novel information and reestablishes the correspondence between the new representations and the objects. The resetting process was marked by a unique neural signature: a sharp drop in the amplitude of the electrophysiological index of VWM contents (the contralateral delay activity), presumably indicating the loss of the existent object-to-representation mappings. This marker was missing when an updating process occurred. Moreover, when tracking moving items, VWM failed to detect salient changes in the object's shape when these changes occurred during the resetting process. This happened despite the object being fully visible, presumably because the mapping between the object and a VWM representation was lost. Importantly, we show that resetting, its neural marker, and the behavioral cost it entails, are specific to situations that involve a destruction of the objects-to-representations correspondence. Visual working memory (VWM) maintains task-relevant information in an online state. Previous studies showed that VWM representations are accessed and modified after changes in the environment. Here, we show that this updating process critically depends on an ongoing mapping between the
Delay or anticipatory synchronization in one-way coupled systems using variable delay with reset
G Ambika; R E Amritkar
2011-11-01
We present a mechanism for the synchronization of one-way coupled nonlinear systems in which the coupling uses a variable delay, that is reset at ﬁnite intervals. Here the delay varies in the same way as the system in time and so the coupling function remains constant for the reset interval at the end of which it is reset to the value at that time. This leads to a novel and discrete error dynamics and the resulting general stability analysis is applicable to chaotic or hyperchaotic systems. We apply this method to standard chaotic systems and hyperchaotic time delay systems. The results of the detailed numerical analysis agree with the results from stability analysis in both cases. This method has the advantage that it is cost-effective since information from the driving system is needed only at intervals of reset. Further, in the context of time delay systems, optimization among the different time-scales depending upon the application is possible due to the ﬂexibility among the four different time-scales in our method, viz. delay in the driving system, anticipation in the response system, system delay time and reset time. We suggest a bi-channel scheme for implementing this method in communication ﬁeld with enhanced security
Apaza-Huallpa Yesenia
2016-10-01
Full Text Available The present research work was conducted in eight communities, Municipality of Achacachi Omasuyos Province, with the following objectives: i calculate the parameters that describe the lactation curve in cows with and without stable. 20 crossbred cows were selected (Holstein crosses with Criollo. 14 and 6 had stable without stable, all were in the last third of gestation to give birth in the months of January month end, February and March earlier this month, milk production was determined from birth until natural drying, their diet was based on native grasslands, pastures of alfalfa, oats and barley (Green, hay and straw. The analysis of the results obtained have on average (a = 4.248, b = 0.348 and c = 0.006 different Ticona (2001, possibly because the average current milk production is (10 kg / day. The average milk production to 305 days of lactation (DL - 305, in cows with stable was 3242.68 kg with an average daily production of 10.6 kg; while the average milk production to 305 days of lactation (PL - 305 in cows without stable was 2621.87 kg, with an average production of 8.6 kg per day. The model proposed by Wood (1967, It was adequate in determining the parameters that define the lactation curve in crossbred cows in the highlands, and to estimate milk production in the town of Achacachi, Omasuyos province, department of La Paz.
Moors, J.H.J.; Banin, V.E.; Haas, J.H.P.; Weber, R.; Veefkind, A. [Eindhoven University of Technology, Eindhoven (Netherlands). Dept. of Applied Physics
1999-01-01
Using a shock tube facility the combustion characteristics of pulverised char ({lt} 10 {mu}m) were measured. A prediction was made for the burnout behaviour of a commercial sized char particle (75-90 {mu}m) in different ambient conditions using a `pseudo kinetic` approach. In this approach the kinetic rate of a surface containing micro pores is determined and these `pseudo kinetics` are then applied to the larger particle not taking into account the micro pores. Comparison of the predictions with measurements done with an isothermal plug flow reactor showed this approach to be valid within experimental error for low burnout. A linear decrease of the kinetic reaction rate with burnout is shown to predict the burnout behaviour in the complete range of burnout. A possible explanation for this linear decrease could be a growing fraction of non-combustible material in the char particles during burnout. 11 refs., 6 figs., 2 tabs.
Marín, José M.; Zalba, Belén; Cabeza, Luisa F.; Mehling, Harald
2003-02-01
The temperature-history method, proposed by Yinping et al, is a simple and economic way to determine the main thermophysical properties of materials used in thermal energy storage based on solid-liquid phase change. It is based on comparing the temperature history of a phase-change material sample and a sample of a well known material upon cooling down. In this paper we describe a further developed evaluation procedure to determine cp and h as temperature dependent values which was not the case in Yinping's method, based on the same experimental procedure. Given the suitability of these properties to calculate thermal energy storage using these materials, the method is proposed to present the results obtained in the form of enthalpy-temperature curves. A discussion about the errors produced by this method and an experimental improvement are proposed too.
Sampaio, C.S.; Sousa, W.O.; Dantas, B.M., E-mail: camilla@ird.gov.br [Instituto de Radioprotecao e Dosimetria, (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)
2014-07-01
Methodologies for the evaluation of uncertainties associated with the determination of the efficiency curve of {sup 210}Pb by liquid scintillation counting (LSC) are presented. No statistical difference were found when compared the uncertainties of the curves that represented the counting net before and after the secular equilibrium between {sup 210}Pb and {sup 210}Bi, nether when compared the curves when counting only {sup 210}Pb and the curve with the total count of {sup 210}Pb and {sup 210}Bi, for the same time interval after precipitation. (author)
Heat production and error probability relation in Landauer reset at effective temperature
Neri, Igor; López-Suárez, Miquel
2016-09-01
The erasure of a classical bit of information is a dissipative process. The minimum heat produced during this operation has been theorized by Rolf Landauer in 1961 to be equal to kBT ln2 and takes the name of Landauer limit, Landauer reset or Landauer principle. Despite its fundamental importance, the Landauer limit remained untested experimentally for more than fifty years until recently when it has been tested using colloidal particles and magnetic dots. Experimental measurements on different devices, like micro-mechanical systems or nano-electronic devices are still missing. Here we show the results obtained in performing the Landauer reset operation in a micro-mechanical system, operated at an effective temperature. The measured heat exchange is in accordance with the theory reaching values close to the expected limit. The data obtained for the heat production is then correlated to the probability of error in accomplishing the reset operation.
Vieira, Jose Wilson
2001-08-01
Brachytherapy is a special form of cancer treatment in which the radioactive source is very close to or inside the tumor with the objective of causing the necrosis of the cancerous tissue. The intensity of cell response to the radiation varies according to the tissue type and degree of differentiation. Since the malign cells are less differentiated than the normal ones, they are more sensitive to the radiation. This is the basis for radiotherapy techniques. Institutes that work with the application of high dose rates use sophisticated computer programs to calculate the necessary dose to achieve the necrosis of the tumor and the same time, minimizing the irradiation of tissues and organs of the neighborhood. With knowledge the characteristics of the source and the tumor, it is possible to trace isodose curves with the necessary information for planning the brachytherapy in patients. The objective of this work is, using Monte Carlo techniques, to develop a computer program - the ISODOSE - which allows to determine isodose curves in turn of linear radioactive sources used in brachytherapy. The development of ISODOSE is important because the available commercial programs, in general, are very expensive and practically inaccessible to small clinics. The use of Monte Carlo techniques is viable because they avoid problems inherent to analytic solutions as, for instance , the integration of functions with singularities in its domain. The results of ISODOSE were compared with similar data found in the literature and also with those obtained at the institutes of radiotherapy of the 'Hospital do Cancer do Recife' and of the 'Hospital Portugues do Recife'. ISODOSE presented good performance, mainly, due to the Monte Carlo techniques, that allowed a quite detailed drawing of the isodose curves in turn of linear sources. (author)
Sokolov, Mikhail A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
2017-05-01
Small specimens are playing the key role in evaluating properties of irradiated materials. The use of small specimens provides several advantages. Typically, only a small volume of material can be irradiated in a reactor at desirable conditions in terms of temperature, neutron flux, and neutron dose. A small volume of irradiated material may also allow for easier handling of specimens. Smaller specimens reduce the amount of radioactive material, minimizing personnel exposures and waste disposal. However, use of small specimens imposes a variety of challenges as well. These challenges are associated with proper accounting for size effects and transferability of small specimen data to the real structures of interest. Any fracture toughness specimen that can be made out of the broken halves of standard Charpy specimens may have exceptional utility for evaluation of reactor pressure vessels (RPVs) since it would allow one to determine and monitor directly actual fracture toughness instead of requiring indirect predictions using correlations established with impact data. The Charpy V-notch specimen is the most commonly used specimen geometry in surveillance programs. Validation of the mini compact tension specimen (mini-CT) geometry has been performed on previously well characterized Midland beltline Linde 80 (WF-70) weld in the unirradiated condition. It was shown that the fracture toughness transition temperature, To, measured by these Mini-CT specimens is almost the same as To value that was derived from various larger fracture toughness specimens. Moreover, an International collaborative program has been established to extend the assessment and validation efforts to irradiated Linde 80 weld metal. The program is underway and involves the Oak Ridge National Laboratory (ORNL), Central Research Institute for Electrical Power Industry (CRIEPI), and Electric Power Research Institute (EPRI). The irradiated Mini-CT specimens from broken halves of previously tested Charpy
Baño, V.
2012-06-01
Full Text Available The objective of this paper is to develop a twodimensional numerical model to simulate the response of Scots pine (Pinus sylvestris L. defect free timber members in order to predict the behaviour of these members when subjected to external forces. For this purpose, data of the mechanical properties of Scots pine were obtained by performing experimental tests on specimens. We determined the stresses and deformations of timber beams in the elastic-plastic and plastic phases. In addition, we developed a finite element software that considered the orthotropic nature of timber, the non-linearity of the compression-reduction branch and the differing moduli of elasticity in tension and compression for Scots pine beams free from defects. The software developed simulates an experimental four point bending test according to UNE-EN 408 Standard.
El objetivo de este trabajo es el desarrollo de un modelo numérico bidimensional de piezas de madera de Pinus sylvestris L. libre de defectos que prediga su comportamiento frente a solicitaciones externas. Para su desarrollo, fue necesario realizar ensayos experimentales sobre probetas de pequeño tamaño con el fin de obtener los datos de las propiedades mecánicas para el Pinus sylvestris L. de procedencia española. A partir de los datos experimentales obtenidos, se desarrolla un programa de elementos finitos que considera la ortotropía de la madera, la no linealidad de la rama compresión-acortamiento y los distintos módulos de elasticidad a tracción y a compresión para vigas libres de defectos. El programa simula el ensayo experimental de flexión en cuatro puntos según la Norma UNE-EN 408 y aborda la determinación de las tensiones y deformaciones de las vigas de madera en las tres fases de comportamiento: elástica, elastoplástica y plástica.
Paryan, Mahdi; Mohammadi-Yeganeh, Samira; Rezvan, Houri; Kia, Vahid; Mansouri, Ardalan; Mirab Samiee, Siamak
2017-02-01
Herpes simplex virus (HSV) is a human pathogen that causes different pathologic manifestations. Rapid and feasible detection and discrimination methods for HSV genotyping is a challenge in clinical laboratories, especially in children suffering from herpetic encephalitis. A quantitative real-time polymerase chain reaction (PCR)-based genotyping assay using SYBR Green I was established. We designed only 1 pair of primer for HSV 1 and 2, targeting thymidine kinase gene conserved region. HSV genotypes were determined by PCR using melting curve analysis with LightCycler. Different HSV genotypes were successfully detected in all clinical samples. The melting temperature for HSV 1 and 2 was 85.5±0.78°C and 89±0.53°C, respectively. These 2 genotypes were completely distinguished by means of the accurate melting assay. Importantly, detection was reliably performed within only 1 hour. The assay had no cross-reactivity across species, an excellent dynamic range from 10 to 10 copies per reaction, a good intra-assay and interassay reproducibility, and a detection limit of a single copy per reaction. Our homebrew designed and validated quantitative real-time PCR followed by a melting curve analysis provided a rapid and convenient screening test for differential identification of HSV genotypes 1 and 2. We recommend the large-scale application of this method for HSV 1 and 2 detection.
Martinez Q, E.; Aguilera, E.F. [Instituto Nacional de Investigaciones Nucleares, Departamento del Acelerador, A.P. 18-1027, 11801 Mexico D.F. (Mexico)
1998-07-01
It is presented a method developed to determine the cross section of 3n channel of the fusion reaction {sup 6} He + {sup 209} Bi which is based in the {alpha} decay curve of residual nucleus, {sup 212} At. (Author)
Bleck, W.; Dahl, W.; Kaluza, W. [Inst. fuer Eisenhuettenkunde, RWTH Aachen (Germany); Budak, I. [Europipe GmbH Werk Muelheim, Muelheim/Ruhr (Germany)
2003-05-01
In the last few years various groups of high-strength cold-rolled steels have been developed for the car body lightweight design. Apart from this materials development, new concepts of lightweight construction have been worked out, as, e.g., welded blanks (so-called tailored blanks). These sheets, consisting of different materials and/or of different sheet thicknesses, are being evaluated in this paper regarding their formability. To this end, forming limit curves are determined by experiment and calculated by means of a finite element model. It turns out that the failure behaviour is influenced by the shape and structure as well as the position of the weld during the forming test. In this process, the width of the weld is more significant than the local hardness increase. (orig.)
Ichinose, Tomoko K; O'Leary, Donal S; Scislo, Tadeusz J
2009-04-01
The role of nucleus of solitary tract (NTS) A(2a) adenosine receptors in baroreflex mechanisms is controversial. Stimulation of these receptors releases glutamate within the NTS and elicits baroreflex-like decreases in mean arterial pressure (MAP), heart rate (HR), and renal sympathetic nerve activity (RSNA), whereas inhibition of these receptors attenuates HR baroreflex responses. In contrast, stimulation of NTS A(2a) adenosine receptors increases preganglionic adrenal sympathetic nerve activity (pre-ASNA), and the depressor and sympathoinhibitory responses are not markedly affected by sinoaortic denervation and blockade of NTS glutamatergic transmission. To elucidate the role of NTS A(2a) adenosine receptors in baroreflex function, we compared full baroreflex stimulus-response curves for HR, RSNA, and pre-ASNA (intravenous nitroprusside/phenylephrine) before and after bilateral NTS microinjections of selective adenosine A(2a) receptor agonist (CGS-21680; 2.0, 20 pmol/50 nl), selective A(2a) receptor antagonist (ZM-241385; 40 pmol/100 nl), and nonselective A(1) + A(2a) receptor antagonist (8-SPT; 1 nmol/100 nl) in urethane/alpha-chloralose anesthetized rats. Activation of A(2a) receptors decreased the range, upper plateau, and gain of baroreflex-response curves for RSNA, whereas these parameters all increased for pre-ASNA, consistent with direct effects of the agonist on regional sympathetic activity. However, no resetting of baroreflex-response curves along the MAP axis occurred despite the marked decreases in baseline MAP. The antagonists had no marked effects on baseline variables or baroreflex-response functions. We conclude that the activation of NTS A(2a) adenosine receptors differentially alters baroreflex control of HR, RSNA, and pre-ASNA mostly via non-baroreflex mechanism(s), and these receptors have virtually no tonic action on baroreflex control of these sympathetic outputs.
Balan, Ranjini; Suraishkumar, G K
2014-01-01
We report for the first time that the endogenous, pseudo-steady-state, specific intracellular levels of the hydroxyl radical (si-OH) oscillate in an ultradian fashion (model system: the microalga, Chlorella vulgaris), and also characterize the various rhythm parameters. The ultradian rhythm in the endogenous levels of the si-OH occurred with an approximately 6 h period in the daily cycle of light and darkness. Further, we expected that the rhythm reset to a shorter period could rapidly switch the cellular redox states that could favor lipid accumulation. We reset the endogenous rhythm through entrainment with UVA radiation, and generated two new ultradian rhythms with periods of approximately 2.97 h and 3.8 h in the light phase and dark phase, respectively. The reset increased the window of maximum lipid accumulation from 6 h to 12 h concomitant with the onset of the ultradian rhythms. Further, the saturated fatty acid content increased approximately to 80% of total lipid content, corresponding to the peak maxima of the hydroxyl radical levels in the reset rhythm.
Re-Setting the Concentration Levels of Students in Higher Education: An Exploratory Study
Burke, Lisa A.; Ray, Ruth
2008-01-01
Evidence suggests that college students' concentration levels are limited and hard to maintain. Even though relevant in higher education, scant empirical research exists on interventions to "re-set" their concentration during a college lecture. Using a within-subjects design, four active learning interventions are administered across two…
RESET Roadmap for European research on Smartcard rElated Technologies
Gras, F.; Le Dantec, B.; Trebucq, O.; Cucinelli, B; Leduc, M.; Simplot, D.; Bueker, U.; Barthe, G.; Michaud, B.; Hartel, P.H.; Thevenot, B.; Moedl, A.; Quisquater, J.J.; Thomasson, J.P.; Canto, E.
2003-01-01
The objective of RESET (Roadmap for European research on Smartcard related Technologies) is to investigate the RTD needs corresponding to current and expected future technology gaps, identified by the industry and resulting from market and product trends foreseen by smart card industrial players. Th
Tajabadi, Fateme; Ghambarian, Mahnaz; Yamini, Yadollah; Yazdanfar, Najmeh
2016-11-01
In the present research, a carrier mediated hollow fiber based liquid-phase microextraction approach (HF-LPME) prior to high performance liquid chromatography-diode array detection (HPLC-DAD) was developed for the simultaneous determination of the antibacterial residues of four tetracyclines (TCs) and five quinolones (QNs), which are commonly used as veterinary medicines. In order to obtain high extraction efficiency, the parameters affecting HF-LPME were optimized using a three-factor and three-level Box-Behnken design under response surface methodology. This method was validated according to the recommendations of the Food and Drug Administration (FDA), and, for the first time, successfully applied to a wide range of animal source food samples such as fish, milk, and honey as well as the liver and muscles of lamb and chicken. Analytical performance was determined in terms of linearity, intra- and inter-assay precision, detection and quantification limits, matrix effect, accuracy, and drug stability in real samples. Detection and quantitation limits for the different antibiotics ranged between 0.5-20ngg(-1) and 1.25-40ngg(-1), respectively. Intra and inter-day repeatability, expressed as the relative standard deviation, were in the ranges of 3.4-10.7% and 5.0-11.5%, respectively. The procedure allows good preconcentration factors of 175-700. The results of the validation process proved that the method is suitable for determining TCs and QNs residues in surveillance programs. Finally, the applicability of the proposed method was successfully confirmed by the extraction and determination of nine antibiotics in various animal source food samples. The importance of this methodology relies on the combination of HF-LPME/HPLC-DAD second-order data with multivariate curve resolution-alternative least squares (MCR-ALS) algorithm, which improves the resolution of some overlapped chromatograms and, hence, increases the accuracy and repeatability of drug determination.
Fach, S; Sitzenfrei, R; Rauch, W
2009-01-01
It is state of the art to evaluate and optimise sewer systems with urban drainage models. Since spill flow data is essential in the calibration process of conceptual models it is important to enhance the quality of such data. A wide spread approach is to calculate the spill flow volume by using standard weir equations together with measured water levels. However, these equations are only applicable to combined sewer overflow (CSO) structures, whose weir constructions correspond with the standard weir layout. The objective of this work is to outline an alternative approach to obtain spill flow discharge data based on measurements with a sonic depth finder. The idea is to determine the relation between water level and rate of spill flow by running a detailed 3D computational fluid dynamics (CFD) model. Two real world CSO structures have been chosen due to their complex structure, especially with respect to the weir construction. In a first step the simulation results were analysed to identify flow conditions for discrete steady states. It will be shown that the flow conditions in the CSO structure change after the spill flow pipe acts as a controlled outflow and therefore the spill flow discharge cannot be described with a standard weir equation. In a second step the CFD results will be used to derive rating curves which can be easily applied in everyday practice. Therefore the rating curves are developed on basis of the standard weir equation and the equation for orifice-type outlets. Because the intersection of both equations is not known, the coefficients of discharge are regressed from CFD simulation results. Furthermore, the regression of the CFD simulation results are compared with the one of the standard weir equation by using historic water levels and hydrographs generated with a hydrodynamic model. The uncertainties resulting of the wide spread use of the standard weir equation are demonstrated.
Khoobi, Asma; Ghoreishi, Sayed Mehdi; Masoum, Saeed; Behpour, Mohsen
2013-12-01
In the present work differential pulse voltammetry coupled with multivariate curve resolution-alternating least squares (MCR-ALS) was applied for simultaneous determination of betaxolol (Bet) and atenolol (Ate) in 0.20 M Britton-Robinson (B-R) buffer solution at the surface of a multi-walled carbon nanotube modified carbon paste electrode (MWCNT/CPE). Characterization of the modified electrode was carried out by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). A strategy based on experimental design was followed. Operating conditions were improved with central composite rotatable design (CCRD) and response surface methodology (RSM), involving several chemical and instrumental parameters. Then second order data were built from variable pulse heights of DPV and after correction in potential shift analyzed by MCR-ALS. Analytical parameters such as linearity, repeatability, and stability were also investigated and a detection limit (DL) of 0.19 and 0.29 μM for Bet and Ate was achieved, respectively. The proposed method was successfully applied in simultaneous determining the two analytes in human plasma.
A phase response curve to single bright light pulses in human subjects
Khalsa, Sat Bir S.; Jewett, Megan E.; Cajochen, Christian; Czeisler, Charles A.
2003-01-01
The circadian pacemaker is differentially sensitive to the resetting effects of retinal light exposure, depending upon the circadian phase at which the light exposure occurs. Previously reported human phase response curves (PRCs) to single bright light exposures have employed small sample sizes, and were often based on relatively imprecise estimates of circadian phase and phase resetting. In the present study, 21 healthy, entrained subjects underwent pre- and post-stimulus constant routines (CRs) in dim light (approximately 2-7 lx) with maintained wakefulness in a semi-recumbent posture. The 6.7 h bright light exposure stimulus consisted of alternating 6 min fixed gaze (approximately 10 000 lx) and free gaze (approximately 5000-9000 lx) exposures. Light exposures were scheduled across the circadian cycle in different subjects so as to derive a PRC. Plasma melatonin was used to determine the phase of the onset, offset, and midpoint of the melatonin profiles during the CRs. Phase shifts were calculated as the difference in phase between the pre- and post-stimulus CRs. The resultant PRC of the midpoint of the melatonin rhythm revealed a characteristic type 1 PRC with a significant peak-to-trough amplitude of 5.02 h. Phase delays occurred when the light stimulus was centred prior to the critical phase at the core body temperature minimum, phase advances occurred when the light stimulus was centred after the critical phase, and no phase shift occurred at the critical phase. During the subjective day, no prolonged 'dead zone' of photic insensitivity was apparent. Phase shifts derived using the melatonin onsets showed larger magnitudes than those derived from the melatonin offsets. These data provide a comprehensive characterization of the human PRC under highly controlled laboratory conditions.
Wann, E.; Lord, O. T.; Dobson, D. P.; Hunt, S. A.; Wood, I. G.; Vocadlo, L.; Ahmed, J.; Walker, A. M.; Santangeli, J. R.; Walter, M. J.
2012-12-01
It is believed that the cores of terrestrial planets consist primarily of an iron-nickel alloy with a small fraction of light elements1. In the case of the Earth, the possible candidates for the light elements are constrained by cosmochemical arguments2. However, although the exact nature of the light element is in dispute, it is widely believed that Si is a significant light element in the core3. Research into the iron-nickel-silicon ternary system is therefore invaluable for our understanding of the composition of the Earth's core and of planetary cores in general. We have initially focused on the FeSi and NiSi end-members as a first step in understanding the ternary system. Recent work on NiSi4,5 has revealed a more complicated phase diagram than that of FeSi, with a range of stable phases found at high pressure and temperature. In order to constrain the liquidus of NiSi, we have carried out experiments in the laser-heated diamond anvil cell (LHDAC) using perturbations in the power versus temperature function as the melting criterion6. Thus far we have determined the melting curve of the room-pressure MnP structured phase to ~20 GPa, which agrees closely with an in situ multi-anvil press experiment in which the melting criteria were 1) the appearance of diffuse scattering during X-ray diffraction and 2) the appearance of convection during X-ray videography. We have also detected the break-in-slope of the melting curve associated with the MnP+ɛ-FeSi+liquid triple point, and extended the melting curve of the ɛ-FeSi structure of NiSi to 50 GPa. We are currently undertaking further experimental work to extend the melting curve above 100 GPa, beyond the pressure at which the CsCl structure becomes the liquid phase. Previous studies indicate that the CsCl structure is likely stable to inner core conditions4,5 making the results of relevance to planetary cores including that of the Earth. (1) Birch, F. Journal of Geophysical Research 1952, 57, 227. (2) Poirier, J. P
Foerster, Sunniva; Golparian, Daniel; Jacobsson, Susanne; Hathaway, Lucy J.; Low, Nicola; Shafer, William M.; Althaus, Christian L.; Unemo, Magnus
2015-01-01
Resistance in Neisseria gonorrhoeae to all available therapeutic antimicrobials has emerged and new efficacious drugs for treatment of gonorrhea are essential. The topoisomerase II inhibitor ETX0914 (also known as AZD0914) is a new spiropyrimidinetrione antimicrobial that has different mechanisms of action from all previous and current gonorrhea treatment options. In this study, the N. gonorrhoeae resistance determinants for ETX0914 were further described and the effects of ETX0914 on the growth of N. gonorrhoeae (ETX0914 wild type, single step selected resistant mutants, and eﬄux pump mutants) were examined in a novel in vitro time-kill curve analysis to estimate pharmacodynamic parameters of the new antimicrobial. For comparison, ciprofloxacin, azithromycin, ceftriaxone, and tetracycline were also examined (separately and in combination with ETX0914). ETX0914 was rapidly bactericidal for all wild type strains and had similar pharmacodynamic properties to ciprofloxacin. All selected resistant mutants contained mutations in amino acid codons D429 or K450 of GyrB and inactivation of the MtrCDE eﬄux pump fully restored the susceptibility to ETX0914. ETX0914 alone and in combination with azithromycin and ceftriaxone was highly effective against N. gonorrhoeae and synergistic interaction with ciprofloxacin, particularly for ETX0914-resistant mutants, was found. ETX0914, monotherapy or in combination with azithromycin (to cover additional sexually transmitted infections), should be considered for phase III clinical trials and future gonorrhea treatment. PMID:26696986
Llamas, Natalia Elizabeth; Garrido, Mariano; Di Nezio, María Susana; Fernández Band, Beatriz Susana
2009-11-23
A direct spectrophotometric method for the determination of three artificial colors--amaranth, sunset yellow FCF and tartrazine--in beverages samples is proposed. The spectra were recorded between 359 and 600 nm. The spectra of the samples (just filtrated), pure dyes (concentrations ranged between 0.01 and 1.8 mg L(-1) for amaranth, 0.08 and 4.4 mg L(-1) for sunset yellow and 0.04 and 1.8 mg L(-1) for tartrazine) and synthetic mixtures were disposed in a column-wise augmented data matrix. This kind of data structure, analyzed by multivariate curve resolution-alternating least squares (MCR-ALS) makes it possible to exploit the so called 'second order advantage'. MCR-ALS algorithm was applied to the experimental data under the non-negativity and equality constraints. As a result, the concentration of each dye in the samples and their corresponding pure spectra were obtained. The results were validated using internal reference materials and no significant differences were found (alpha=5%) between the reference values and the ones obtained with the proposed method. The second order advantage made it possible to obtain unbiased results even in the presence of interferences.
Sunniva eFoerster
2015-12-01
Full Text Available Resistance in Neisseria gonorrhoeae to all available therapeutic antimicrobials has emerged and new efficacious drugs for treatment of gonorrhea are essential. The topoisomerase II inhibitor ETX0914 (also known as AZD0914 is a new spiropyrimidinetrione antimicrobial that has different mechanisms of action from all previous and current gonorrhea treatment options. In this study, the N. gonorrhoeae resistance determinants for ETX0914 were further described and the effects of ETX0914 on the growth of N. gonorrhoeae (ETX0914 wild type, single step selected resistant mutants, and efflux pump mutants were examined in a novel in vitro time-kill curve analysis to estimate pharmacodynamic parameters of the new antimicrobial. For comparison, ciprofloxacin, azithromycin, ceftriaxone, and tetracycline were also examined (separately and in combination with ETX0914. ETX0914 was rapidly bactericidal for all wild type strains and had similar pharmacodynamic properties to ciprofloxacin. All selected resistant mutants contained mutations in amino acid codons D429 or K450 of GyrB and inactivation of the MtrCDE efflux pump fully restored the susceptibility to ETX0914. ETX0914 alone and in combination with azithromycin and ceftriaxone was highly effective against N. gonorrhoeae and synergistic interaction with ciprofloxacin, particularly for ETX0914-resistant mutants, was found. ETX0914, monotherapy or in combination with azithromycin (to cover additional sexually transmitted infections, should be considered for phase III clinical trials and future gonorrhea treatment.
Li, Zeyu; Li, Jie; Lange, Rebecca; Liu, Jiachao; Militzer, Burkhard
2017-01-01
Melting of carbonated eclogite or peridotite in the mantle influences the Earth's deep volatile cycles and bears on the long-term evolution of the atmosphere. Existing data on the melting curves of calcium carbonate (CaCO3) and sodium carbonate (Na2CO3) are limited to 7 GPa and therefore do not allow a full understanding of carbon storage and cycling in deep Earth. We determined the melting curves of CaCO3 and Na2CO3 to the pressures of Earth's transition zone using a multi-anvil apparatus. Melting was detected in situ by monitoring a steep and large increase in ionic conductivity, or inferred from sunken platinum markers in recovered samples. The melting point of CaCO3 rises from 1870 K at 3 GPa to ∼2000 K at 6 GPa and then stays within 50 K of 2000 K between 6 and 21 GPa. In contrast, the melting point of Na2CO3 increases continuously from ∼1123 K at 3 GPa to ∼1950 K at 17 GPa. A pre-melting peak in the alternating current through solid CaCO3 is attributed to the transition from aragonite to calcite V. Accordingly the calcite V-aragonite-liquid invariant point is placed at 13 ± 1 GPa and 1970 ± 40 K, with the Clapeyron slope of the calcite V to aragonite transition constrained at ∼70 K/GPa. The experiments on CaCO3 suggest a slight decrease in the melting temperature from 8 to 13 GPa, followed by a slight increase from 14 to 21 GPa. The negative melting slope is consistent with the prediction from our ab initio simulations that the liquid may be more compressible and become denser than calcite V at sufficiently high pressure. The positive melting slope at higher pressures is supported by the ab initio prediction that aragonite is denser than the liquid at pressures up to 30 GPa. At transition zone pressures the melting points of CaCO3 are comparable to that of Na2CO3 but nearly 400 K and 500 K lower than that of MgCO3. The fusible nature of compressed CaCO3 may be partially responsible for the majority of carbonatitic melts found on Earth's surface
McGee, John J.
2006-01-01
Elliptic curves have a rich mathematical history dating back to Diophantus (c. 250 C.E.), who used a form of these cubic equations to find right triangles of integer area with rational sides. In more recent times the deep mathematics of elliptic curves was used by Andrew Wiles et. al., to construct a proof of Fermat's last theorem, a problem which challenged mathematicians for more than 300 years. In addition, elliptic curves over finite fields find practical application in the areas of cr...
Optimization of a PCRAM Chip for high-speed read and highly reliable reset operations
Li, Xiaoyun; Chen, Houpeng; Li, Xi; Wang, Qian; Fan, Xi; Hu, Jiajun; Lei, Yu; Zhang, Qi; Tian, Zhen; Song, Zhitang
2016-10-01
The widely used traditional Flash memory suffers from its performance limits such as its serious crosstalk problems, and increasing complexity of floating gate scaling. Phase change random access memory (PCRAM) becomes one of the most potential nonvolatile memories among the new memory techniques. In this paper, a 1M-bit PCRAM chip is designed based on the SMIC 40nm CMOS technology. Focusing on the read and write performance, two new circuits with high-speed read operation and highly reliable reset operation are proposed. The high-speed read circuit effectively reduces the reading time from 74ns to 40ns. The double-mode reset circuit improves the chip yield. This 1M-bit PCRAM chip has been simulated on cadence. After layout design is completed, the chip will be taped out for post-test.
Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.
Wang, Yanchang; Shirogane, Takahiro; Liu, Dou; Harper, J Wade; Elledge, Stephen J
2003-03-07
In S. cerevisiae cells undergoing anaphase, a ras-related GTPase, Tem1, is located on the spindle pole body that enters the daughter cell and activates a signal transduction pathway, MEN, to allow mitotic exit. MEN activation must be reversed after mitotic exit to reset the cell cycle in G1. We find that daughter cells activate an Antagonist of MEN pathway (AMEN) in part through induction of the Amn1 protein that binds directly to Tem1 and prevents its association with its target kinase Cdc15. Failure of Amn1 function results in defects of both the spindle assembly and nuclear orientation checkpoints and delays turning off Cdc14 in G1. Thus, Amn1 is part of a daughter-specific switch that helps cells exit from mitotic exit and reset the cell cycle.
Gaudin, M. [Electricite de France (EDF), Direction des Etudes et Recherches, 92 - Clamart (France)
1997-12-31
Resetting models is applied to electricity generating plant pipework systems. A frequency approach to the problem is made in an original way thanks to the use of precise dynamic rigidity matrices. The method assumes two kinds of unknown: the usually processed mechanical characteristics (Young`s Modulus, density etc.) and new resetting parameters acting on the dynamic behaviour of unknown connections. As the latter have a very wide range of possible variation, they benefit from a change of variable which allows the assumptions formulated to be complied with. The minimized cost function is based on a error in load. The frequencies required for building it are automatically selected thanks to different tests on measurements. Minimization uses a sensitivity technique linked with a method of least standard squares. The method has been programmed in Fortran 90 within the CIRCUS code and tried out on various examples which were simulated and sound effects cases as well as an actual case. (author). 128 refs.
Design of programmable logic controller auto power reset circuit for FM transmitter
Adisak Pattanajakr
2016-06-01
Full Text Available The mono-stereo controller using audio mute clock is used at the International Broadcasting Bureau (IBB FM 106.6 MHz transmitter in Ulaan Baatar, Mongolia since 2010. The major problem of the FM broadcast station was from the frozen Programmable Logic Controller, PLC, which must be manually reset and the report by the VOA listeners. Then, the PLC auto power reset circuit is proposed and built in mono-stereo controller to monitor the operation of the PLC. The circuit is also used to restart the PLC whenever, it is frozen. The cloud router and Transmission Control Protocol/Internet Protocol (TCP/IP to Recommended Standard number 232 (RS-232 converter are used to synchronize the PLC time. From the results, this circuit can improve the transmitter availability and quality of the 24 hours/day broadcast program without affection to the listeners. The reliability of the cloud router is acceptable with low delay of data transfer via the internet connection between Thailand to Mongolia. The cloud router which the IBB leases cloud service from the provider that offers high speed internet up to 1000 Mb/s, via the remote terminal is used for the schedule program and the time synchronization of the PLC correctly. The proposed system is very stable and there is no problem of the frozen PLC whether it connects to the internet or not. Hence, the designed PLC auto power reset circuit can be used to eliminate the frozen PLC problem.
Morning and Evening Oscillators Cooperate to Reset Circadian Behavior in Response to Light Input
Pallavi Lamba
2014-05-01
Full Text Available Light is a crucial input for circadian clocks. In Drosophila, short light exposure can robustly shift the phase of circadian behavior. The model for this resetting posits that circadian photoreception is cell autonomous: CRYPTOCHROME senses light, binds to TIMELESS (TIM, and promotes its degradation, which is mediated by JETLAG (JET. However, it was recently proposed that interactions between circadian neurons are also required for phase resetting. We identify two groups of neurons critical for circadian photoreception: the morning (M and the evening (E oscillators. These neurons work synergistically to reset rhythmic behavior. JET promotes acute TIM degradation cell autonomously in M and E oscillators but also nonautonomously in E oscillators when expressed in M oscillators. Thus, upon light exposure, the M oscillators communicate with the E oscillators. Because the M oscillators drive circadian behavior, they must also receive inputs from the E oscillators. Hence, although photic TIM degradation is largely cell autonomous, neural cooperation between M and E oscillators is critical for circadian behavioral photoresponses.
Zhou, Peng; Ye, Li; Sun, Qing Qing; Wang, Peng Fei; Jiang, An Quan; Ding, Shi Jin; Zhang, David Wei
2013-02-19
The RESET process of NbAlO-based resistive switching memory devices fabricated by atomic layer deposition is investigated at low temperatures from 80 to 200 K. We observed that the conduction mechanism of high resistance state changed from hopping conduction to Frenkel-Poole conduction with elevated temperature. It is found that the conductive filament rupture in RRAM RESET process can be attributed not only to the Joule heat generated by internal current flow through a filament but also to the charge trap/detrapping effect. The RESET current decreases upon heating. Meanwhile, the energy consumption also decreases exponentially. This phenomenon indicates the temperature-related charge trap/detrapping process which contributes to the RESET besides direct Joule heat.
RESETTING AND REINVENTING PRINT MEDIA: LEARNING FROM COLLEGE MEDIA
Alyssa Jackson
2017-01-01
Full Text Available A readership study, employing an online survey (n = 275, was conducted to determine the reading preferences of students, faculty, staff, and alumni for the student magazine and web site of a technological university. The print version (53% was preferred over the online version (22%, with 25% having no preference. Internet and social media were the preferred news media with Facebook dominating all other sites. Few had downloaded the app (7%, despite the fact that 92% owned smartphones. Attitudes toward news were positive and predictive of reading specific sections. Reading the technology section was significantly related to being “part of my daily habit,” “part of my civic duty,” “helpful in making choices,” and negatively related to “inconvenient.” Additional qualitative responses are discussed.
Caroff, Jildaz; Jittapiromsak, Pakrit; Benachour, Nidhal; Mihalea, Cristian; Rouchaud, Aymeric; Neki, Hiroaki; Ikka, Leon; Moret, Jacques; Spelle, Laurent [Beaujon Medical Center, NEURI - Interventional Neuroradiology, Paris Diderot University, Clichy (France); Ruijters, Daniel [Philips Healthcare, Interventional X-Ray Innovation, Best (Netherlands)
2014-03-15
Cerebral blood volume (CBV) measurement by flat panel detector CT (FPCT) in the angiography suite seems to be a promising tool for patient management during endovascular therapies. A steady state of contrast agent distribution is mandatory during acquisition for accurate FPCT CBV assessment. To the best of our knowledge, this was the first time that steady-state parameters were studied in clinical practice. Before the CBV study, test injections were performed and analyzed to determine a customized acquisition delay from injection for each patient. Injection protocol consisted in the administration of 72 mL of contrast agent material at the injection rate of 4.0 mL/s followed by a saline flush bolus at the same injection rate. Peripheral or central venous accesses were used depending on their availability. Twenty-four patients were treated for different types of neurovascular diseases. Maximal attenuation, steady-state length, and steady-state delay from injection were derived from the test injections' time attenuation curves. With a 15 % threshold from maximum attenuation values, average steady-state duration was less than 10 s. Maximum average steady-state duration with minimal delay variation was obtained with central injection protocols. With clinically acceptable contrast agent volumes, steady state is a brief condition; thus, fast rotation speed acquisitions are needed. The use of central injections decreases the variability of steady-state's delay from injection. Further studies are needed to optimize and standardize injection protocols to allow a larger diffusion of the FPCT CBV measurement during endovascular treatments. (orig.)
Interpolation and Polynomial Curve Fitting
Yang, Yajun; Gordon, Sheldon P.
2014-01-01
Two points determine a line. Three noncollinear points determine a quadratic function. Four points that do not lie on a lower-degree polynomial curve determine a cubic function. In general, n + 1 points uniquely determine a polynomial of degree n, presuming that they do not fall onto a polynomial of lower degree. The process of finding such a…
Silchenko, Alexander N; Adamchic, Ilya; Hauptmann, Christian; Tass, Peter A
2013-08-15
Chronic subjective tinnitus is an auditory phantom phenomenon characterized by abnormal neuronal synchrony in the central auditory system. As recently shown in a proof of concept clinical trial, acoustic coordinated reset (CR) neuromodulation causes a significant relief of tinnitus symptoms combined with a significant decrease of pathological oscillatory activity in a network comprising auditory and non-auditory brain areas. The objective of the present study was to analyze whether CR therapy caused an alteration of the effective connectivity in a tinnitus related network of localized EEG brain sources. To determine which connections matter, in a first step, we considered a larger network of brain sources previously associated with tinnitus. To that network we applied a data-driven approach, combining empirical mode decomposition and partial directed coherence analysis, in patients with bilateral tinnitus before and after 12 weeks of CR therapy as well as in healthy controls. To increase the signal-to-noise ratio, we focused on the good responders, classified by a reliable-change-index (RCI). Prior to CR therapy and compared to the healthy controls, the good responders showed a significantly increased connectivity between the left primary cortex auditory cortex and the posterior cingulate cortex in the gamma and delta bands together with a significantly decreased effective connectivity between the right primary auditory cortex and the dorsolateral prefrontal cortex in the alpha band. Intriguingly, after 12 weeks of CR therapy most of the pathological interactions were gone, so that the connectivity patterns of good responders and healthy controls became statistically indistinguishable. In addition, we used dynamic causal modeling (DCM) to examine the types of interactions which were altered by CR therapy. Our DCM results show that CR therapy specifically counteracted the imbalance of excitation and inhibition. CR significantly weakened the excitatory connection
Benjamin eVoloh
2016-03-01
Full Text Available Short periods of oscillatory activation are ubiquitous signatures of neural circuits. A broad range of studies documents not only their circuit origins, but also a fundamental role for oscillatory activity in coordinating information transfer during goal directed behavior. Recent studies suggest that resetting the phase of ongoing oscillatory activity to endogenous or exogenous cues facilitates coordinated information transfer within circuits and between distributed brain areas. Here, we review evidence that pinpoints phase resetting as a critical marker of dynamic state changes of functional networks. Phase resets (1 set a neural context in terms of narrow band frequencies that uniquely characterizes the activated circuits, (2 impose coherent low frequency phases to which high frequency activations can synchronize, identifiable as cross-frequency correlations across large anatomical distances, (3 are critical for neural coding models that depend on phase, increasing the informational content of neural representations, and (4 likely originate from the dynamics of canonical E-I circuits that are anatomically ubiquitous. These multiple signatures of phase resets are directly linked to enhanced information transfer and behavioral success. We survey how phase resets re-organize oscillations in diverse task contexts, including sensory perception, attentional stimulus selection, cross-modal integration, Pavlovian conditioning, and spatial navigation. The evidence we consider suggests that phase-resets can drive changes in neural excitability, ensemble organization, functional networks, and ultimately, overt behavior.
Do Planetary Encounters Reset Surfaces of Near Earth Asteroids?
Nesvorny, David; Vokrouhlicky, David; Chapman, Clark R; Rafkin, Scot
2010-01-01
Processes such as the solar wind sputtering and micrometeorite impacts can modify optical properties of surfaces of airless bodies. This explains why spectra of the main belt asteroids, exposed to these `space weathering' processes over eons, do not match the laboratory spectra of ordinary chondrite (OC) meteorites. In contrast, an important fraction of Near Earth Asteroids (NEAs), defined as Q-types in the asteroid taxonomy, display spectral attributes that are a good match to OCs. Here we study the possibility that the Q-type NEAs underwent recent encounters with the terrestrial planets and that the tidal gravity (or other effects) during these encounters exposed fresh OC material on the surface (thus giving it the Q-type spectral properties). We used numerical integrations to determine the statistics of encounters of NEAs to planets. The results were used to calculate the fraction and orbital distribution of Q-type asteroids expected in the model as a function of the space weathering timescale, t_sw (see m...
Chen, F.; Baffa, O.; Graeff, C.F.O. [Departamento de Fisica e Matematica. Universidade de Sao Paulo FFCLRP. 14040-901 Ribeirao Preto-SP (Brazil)
1998-12-31
It was studied the possible use of an Alanine/ESR dosemeter in the isodose curves mapping in normal treatments of Radiotherapy. It was manufactured a lot of 150 dosemeters with base in a mixture of D-L Alanine dust (80 %) and paraffin (20 %). Each dosemeter has 4.7 mm diameter and 12 mm length. A group of 100 dosemeters of the lot were arranged inside 50 holes of the slice 25 of the phantom Rando Man. The phantom irradiation was realized in two opposed projections (AP and PA) in Co-60 equipment. A group of 15 dosemeters was take of the same lot for obtaining the calibration curve in a 1-20 Gy range. After irradiation the signal of each dosemeter was measured in an ESR spectrometer operating in the X-band ({approx} 9.5 GHz) and the wideness of Alanine ESR spectra central line was correlated with the radiation dose. The wideness dose calibration curve resulted linear with a correlation coefficient 0.9996. The isodose curves obtained show a profile enough similar at comparing with the theoretical curves. (Author)
Reinsperger, Tony; Luy, Burkhard
2014-02-01
Heteronuclear one-bond couplings are of interest for various aspects of structural analysis of small organic molecules, including for example the distinction of axial and equatorial protons or the use of RDCs as angular constraints. Such couplings are most easily measured from pure doublets in HSQC-type spectra. Recently, the fully decoupled RESET HSQC experiment was reported and several other so-called pure-shift methods followed that allow for the removal of splittings due to homonuclear scalar interactions in one and two-dimensional NMR. In this work we present broadband homonuclear decoupled CLIP/CLAP-RESET experiments based on an isotope-selective BIRD filter element using a recently reported improved version of Zangger-Sterk data chunking. The concatenated FIDs result in multiplets in which most homonuclear splittings are removed while the heteronuclear one-bond couplings are retained. Couplings can be extracted in an IPAP fashion without scaling of subspectra by the use of optimized coherence transfer elements like the COB-INEPT. The method leads to complete homonuclear decoupling for CH groups and CH3 groups in isotropic samples, but leaves residual splittings with antiphase contributions for e.g. CH2 groups due to (2)JHH coupling evolution that is not affected by the BIRD element. For this case we present a constant-time version of the proposed BIRD decoupling scheme with full homonuclear decoupling. In addition, the effects of strong coupling are discussed. Strong coupling artifacts cannot be circumvented, but the proposed experiments allow their distinct recognition.
Goulart, A.O.S.; Costa, A.T.; Puricelli, E.L.; Bernasiuk, M.E.B.; Bacelar, A. [Pontificia Univ. Catolica do Rio Grande do Sul, Porto Alegre, RS (Brazil). Faculdade de Fisica]. E-mail: adrianoosg@bol.com.br; Ferlin, E.L. [Hospital de Clinicas de Porto Alegre, RS (Brazil). Fisica Medica. Grupo de Pesquisa e Pos-graduacao
2001-07-01
This research has the object determine curves with same exposure of one equipment of digital fluoroscopy used in cardiovascular procedures in one hemodynamic room, for minimize the effective dose of occupationally workers exposure. For to carry out the measures of levels exposure in bend all equipment in the Cardiologic Service in the Hemodynamic Unit of the Clinicas of Porto Alegre Hospital, used one ionization chamber. The same curves exposure shows asymmetrical on next part of the x-ray tubes - image intensificator for the tree projections with the C-arm of the digital fluoroscopy. (author)
Zola, S.; Baran, A.; Debski, B.; Jableka, D.
2017-04-01
The Kepler mission observations, taken in the long cadence mode, have a time resolution of about 30 min. In this paper, we investigate how the long cadence binning influences the shapes of the light curves of eclipsing binaries. A simulated light curve of a contact binary exhibiting a flat-bottom secondary minimum was applied for this purpose. We found that the binning caused a change in the variation amplitude and the shape of the minima. We modelled the simulated light curves corresponding to periods between 0.2 and 2 d using a code that does not account for binning and we derived the parameters. It turned out that only when the binary period is close to or longer than about 1.5 d are the solutions derived with such a code accurate. Rigorous modelling of systems with shorter periods requires the use of codes that do account for phase smearing due to long exposure times. We selected a sample of contact binaries observed by the Kepler mission, exhibiting a flat-bottom secondary minimum and showing no intrinsic activity. We solved the light curves of the sample with the most recent (2015) version of the Wilson-Devinney code and we derived the system parameters. The best models that we derived indicate that most of the systems in our sample have a deep contact configuration and that 13 out of 17 required the addition of a third light for good fits. Our results suggest that 13 systems could have tertiary companions.
Maran, Selva K; Canavier, Carmen C
2008-02-01
Our goal is to understand how nearly synchronous modes arise in heterogenous networks of neurons. In heterogenous networks, instead of exact synchrony, nearly synchronous modes arise, which include both 1:1 and 2:2 phase-locked modes. Existence and stability criteria for 2:2 phase-locked modes in reciprocally coupled two neuron circuits were derived based on the open loop phase resetting curve (PRC) without the assumption of weak coupling. The PRC for each component neuron was generated using the change in synaptic conductance produced by a presynaptic action potential as the perturbation. Separate derivations were required for modes in which the firing order is preserved and for those in which it alternates. Networks composed of two model neurons coupled by reciprocal inhibition were examined to test the predictions. The parameter regimes in which both types of nearly synchronous modes are exhibited were accurately predicted both qualitatively and quantitatively provided that the synaptic time constant is short with respect to the period and that the effect of second order resetting is considered. In contrast, PRC methods based on weak coupling could not predict 2:2 modes and did not predict the 1:1 modes with the level of accuracy achieved by the strong coupling methods. The strong coupling prediction methods provide insight into what manipulations promote near-synchrony in a two neuron network and may also have predictive value for larger networks, which can also manifest changes in firing order. We also identify a novel route by which synchrony is lost in mildly heterogenous networks.
Klein, William Francis
2013-01-01
We now exist in an era where for the first time, symbolic representation may precede the natural world in human experience. Aristotle's a priori terrain has been upstaged. We are changing the nature of our own evolution in profound ways. The question becomes, "How do we transcend the chaos of meaning in this post-modern condition or…
张正斌; 刘莲生; 刘国盛; 俞志明
1996-01-01
A new method is suggested for determining the stability constant of ternary surface complexes (TSC) at liquid-solid interfaces in natural water. Its basic principle is based on the rule of left-right shift (RLRS) of S-shaped curve, from which the peak-type curve of E(%) with the concentration of organic matter is obtained. The peak-type curve is further used to obtain the (ksAM/kSM) values by using respectively the method of equality of E(%) when [H2A] = [H2A]0 (1) and the method of [H2A]max (2). From the known KSM,the stability constant KSAM of liquid-solid interfacial ternary surface complexes can be obtained.
Saccadic reaction times to audiovisual stimuli show effects of oscillatory phase reset.
Adele Diederich
Full Text Available Initiating an eye movement towards a suddenly appearing visual target is faster when an accessory auditory stimulus occurs in close spatiotemporal vicinity. Such facilitation of saccadic reaction time (SRT is well-documented, but the exact neural mechanisms underlying the crossmodal effect remain to be elucidated. From EEG/MEG studies it has been hypothesized that coupled oscillatory activity in primary sensory cortices regulates multisensory processing. Specifically, it is assumed that the phase of an ongoing neural oscillation is shifted due to the occurrence of a sensory stimulus so that, across trials, phase values become highly consistent (phase reset. If one can identify the phase an oscillation is reset to, it is possible to predict when temporal windows of high and low excitability will occur. However, in behavioral experiments the pre-stimulus phase will be different on successive repetitions of the experimental trial, and average performance over many trials will show no signs of the modulation. Here we circumvent this problem by repeatedly presenting an auditory accessory stimulus followed by a visual target stimulus with a temporal delay varied in steps of 2 ms. Performing a discrete time series analysis on SRT as a function of the delay, we provide statistical evidence for the existence of distinct peak spectral components in the power spectrum. These frequencies, although varying across participants, fall within the beta and gamma range (20 to 40 Hz of neural oscillatory activity observed in neurophysiological studies of multisensory integration. Some evidence for high-theta/alpha activity was found as well. Our results are consistent with the phase reset hypothesis and demonstrate that it is amenable to testing by purely psychophysical methods. Thus, any theory of multisensory processes that connects specific brain states with patterns of saccadic responses should be able to account for traces of oscillatory activity in observable
Resetting AUDI Algorithm Used in Rapid Time-varying MIMO System Identification
Xu Chao(许超); Chen Zhigang; Shao Huihe
2004-01-01
Augmented UD identification (AUDI) technique is derived from the traditional recursive least-squares (RLS) algorithm and has been developed rapidly during the last decade. AUDI is a cluster of identification algorithms based on matrix factorization methods (such as QR and LDL) and thus shows its stable performance in system identification applications. An AUDI algorithm with resetting strategy (RAUDI) has much ability in rapid time-varying SISO system identification. In this paper, an endeavor to expand the RAUDI in MIMO system identification is made and a comparative experiement is done to exhibit its good ability in rapidly changing parameter estimate in MIMO system.
YUEYuncan; QIANJixin
2002-01-01
Based on the idea of the set-membership identification,a modified recursive least squares algorithm with variable gain, variable forgetting factor and resetting is presented.The concept of the error tolerance level is proposed.The selection criteria of the error tolerance level are also given according to the min-max principle.The algorithm is particularly suitable for tracing time-varying systems and is similar in computational complexity to the standard recursive least squares algorithm.The superior performance of the algorithm is verified via simulation studies on a dynamic fermentation process.
Inspiring students through an authentic polar science expedition: the RESEt Project
Cattadori, Matteo
2016-04-01
RESEt (Research and Education Svalbard Experience www.resetsvalbard.it) is an ongoing educational project focusing mainly on polar and climate system topics. It started in 2014 and will end in 2017 with the high school diploma of the 22 students (16 y. o.) making the participant class. This class attend a school (Liceo Filzi, Rovereto, Trento. Italy) with a primary focus on disciplines like philosophy and education, rather then STEM (Science, Technology, Engineering, and Mathematics). Nevertheless their science curricula include climate topics that are rather challenging to grasp and, at the same time, crucial for their scientific citizenship. Some questions arise: How to foster their interest in geosciences topics? How to engage them in authentic scientific knowledge? How to increase their interest in scientific university courses during their post-secondary career? RESEt project will attempt to answer these questions through the development of integrated activities distributed over the last three years of their high school cycle. The most important moment will be an educational scientific expedition at the Svalbard, an archipelago located in the Arctic. The expedition be entirely organized, planned, and directed by students. In Svalbard, students will visit the main scientific facilities devoted to climate studies including those of Italian CNR (National Research Council) and they will perform some environmental measurement using data-loggers. Students are even involved in the fundraising process to raise more than ten thousand Euros needed to for travel expenses. This work is aimed mainly at presenting some of the preliminary data collected during the RESEt project, including the fundraising aspects. The management of the RESEt project strongly relies on the experience and network gained by the abstract author during the participation to the Education and Public Outreach (EPO) program of International Polar Year (IPY) 2007-2009 as well as the support of Polar
E. Durán
2012-01-01
Full Text Available A versatile measurement system for systematic testing and measurement of the evolution of the I-V characteristic curves of photovoltaic panels or arrays (PV generators is proposed in this paper. The measurement system uses a circuit solution based on DC-DC converters that involves several advantages relative to traditional methods: simple structure, scalability, fast response, and low cost. The measurement of the desired characteristics of PV generators includes high speed of response and high fidelity. The prototype system built is governed by a microcontroller, and experimental results prove the proposed measurement system useful. A virtual instrument (VI was developed for full system control from a computer. The developed system enables monitoring the suitable operation of a PV generator in real time, since it allows comparing its actual curves with those provided by the manufacturer.
蒋婧
2012-01-01
Determination of hydrolysis degree of protein using ninhydrin colorimetric method and formation of its standard curve are analyzed.Furthermore,method of standard curve formation is studied by linear regression based on Excell and Matlab.The source code of standard curve formation is written.An available method is presented on standard curve formation during determination of hydrolysis degree of protein and industry analysis.%应用茚三酮显色法对蛋白质水解度的测定及其标准曲线生成进行了分析。进而,基于一元线性回归分别在Excell和Matlab平台上对标准曲线的生成进行了研究,并给出了相应的标准曲线生成源代码,为蛋白质水解度的控制及工业分析中各标准曲线的绘制提供了必要的手段和方法。
Multiphasic growth curve analysis.
Koops, W.J.
1986-01-01
Application of a multiphasic growth curve is demonstrated with 4 data sets, adopted from literature. The growth curve used is a summation of n logistic growth functions. Human height growth curves of this type are known as "double logistic" (n = 2) and "triple logistic" (n = 3) growth curves (Bock
Counting rational points on cubic curves
HEATH-BROWN; Roger; TESTA; Damiano
2010-01-01
We prove upper bounds for the number of rational points on non-singular cubic curves defined over the rationals.The bounds are uniform in the curve and involve the rank of the corresponding Jacobian.The method used in the proof is a combination of the "determinant method" with an m-descent on the curve.
New low power adders in Self Resetting Logic with Gate Diffusion Input Technique
R. Uma
2017-04-01
Full Text Available The objective vividly defines a new low-power and high-speed logic family; named Self Resetting Logic with Gate Diffusion Input (SRLGDI. This logic family resolves the issues in dynamic circuits like charge sharing, charge leakage, short circuit power dissipation, monotonicity requirement and low output voltage. In the proposed design structure of SRLGDI, the pull down tree is implemented with Gate Diffusion Input (GDI with level restoration which apparently eliminated the conductance overlap between nMOS and pMOS devices, thereby reducing the short circuit power dissipation and providing High Output Voltage VoH. The output stage of SRLGDI has been incorporated with an inverter to produce both true and complementary output function. The Resistance Capacitance (RC delay model has been proposed to obtain the total delay of the circuit during precharge and evaluation phases. Using SRLGDI, the primitive cells and 3 different full adder circuits were designed and simulated in a 0.250 μm Complementary Metal Oxide Semiconductor (CMOS process technology. The simulated result demonstrates that the proposed SRLGDI logic family is superior in terms of speed and power consumption with respect to other logic families like Dynamic logic (DY, CMOS, Self Resetting CMOS (SRCMOS and GDI.
Augmented brain function by coordinated reset stimulation with slowly varying sequences
Magteld eZeitler
2015-03-01
Full Text Available Several brain disorders are characterized by abnormally strong neuronal synchrony. Coordinated Reset (CR stimulation was developed to selectively counteract abnormal neuronal synchrony by desynchronization. For this, phase resetting stimuli are delivered to different subpopulations in a timely coordinated way. In neural networks with spike timing-dependent plasticity CR stimulation may eventually lead to an anti-kindling, i.e. an unlearning of abnormal synaptic connectivity and abnormal synchrony. The spatiotemporal sequence by which all stimulation sites are stimulated exactly once is called the stimulation site sequence, or briefly sequence. So far, in simulations, pre-clinical and clinical applications CR was applied either with fixed sequences or rapidly varying sequences (RVS. In this computational study we show that appropriate repetition of the sequence with occasional random switching to the next sequence may significantly improve the anti-kindling effect of CR. To this end, a sequence is applied many times before randomly switching to the next sequence. This new method is called SVS CR stimulation, i.e. CR with slowly varying sequences. In a neuronal network with strong short-range excitatory and weak long-range inhibitory dynamic couplings SVS CR stimulation turns out to be superior to CR stimulation with fixed sequences or RVS.
LOW POWER-AREA DESIGN OF FULL ADDER USING SELF RESETTING LOGIC WITH GDI TECHNIQUE
Simran Khokha1
2016-08-01
Full Text Available Various electronic devices such as mobile phones, DSPs,ALU etc., are designed by using VLSI (Very Large Scale Integration technology. In VLSI dynamic CMOS logic circuits are concentrating on the Area ,reducing the power consumption and increasing the Speed by reducing the delay. ALU (Arithmetic Logic Circuits are designed by using adder, subtractors, multiplier, divider, etc.Various adder circuits designs have been proposed over last few years with different logic styles. To reduce the power consumption several parameters are to be taken into account, such as feedthrough, leakage power single-event upsets, charge sharing by parasitic components while connecting source and drain of CMOS transistors There are situations in a logic that permit the use of circuits that can automatically precharge themselves (i.e., reset themselves after some prescribed delays. These circuits are hence called postcharge or self-resetting logic which are widely used in dynamic logic circuits. Overall performance of various adder designs is evaluated by using Tanner tool . The earlier and the proposed SRLGDI primitives are simulated using Tanner EDA with BSIM 0.250 lm technology with supply voltage ranging from 0 V to 5 V in steps of 0.2 V. On comparing the various SRLGDI logic adders, the proposed adder shows low power, delay and low PDP among its counterparts.
Tkachenko, Mariia G
2016-01-01
The dependence of the test function on the phenomenological parameters used in the "NAV" ("New Algol Variable") algorithm (Andronov, 2012Ap.....55..536A) is studied. Due to a presence of local minima, the method of minimization contains two steps: the "brute force" minimization at a grid in the 4D parameter space, and further iterations using the differential corrections. This method represents an effective approximation of the light curve using the special pattern (shape) separately for the primary and secondary minima. The application of the method to concrete stars is briefly reviewed.
Raidt, Robert; Smith, Andrew J.; Oprisan, Sorinel A.
2012-02-01
Neurons are complex excitable cells with a highly nonlinear response to external perturbations, such as presynaptic inputs and biological noise. Single-cell activity is determined by the properties of ionic channels and the ionic makeup of cell's environment and is mathematically described by coupled and nonlinear evolution equations. The phase resetting curve (PRC) reduces the complexity of the biophysical mechanisms involved in generating action potentials to tabulating advances or delays of subsequent spikes of a neuron due to an external perturbation. The PRC is widely used to predict the activity of large neural networks that by replacing the computationally intensive integration of evolution equations with lookup tables. The fundamental assumption of the PRC approach in predicting phase-locked modes in coupled neural networks is that the transient PRC measured for isolated and bursting neurons (open-loop) remains the same under the recurrent inputs of a phase-locked mode (close-loop). The novelties of our approach are: 1) the use of discrete sine transforms (DST's) to store the PRC's as a series of coefficients, and 2) the use of multidimensional stacks to represent multidimensional objects.
SET and RESET states of As2Se3 doped GeTe4 bulk glasses probed by Raman spectroscopy
Pumlianmunga, Ramesh, K.
2016-12-01
Te based chalcogenide glasses are being explored for non-volatile memory applications. We report the electrical switching studies on bulk Ge0.20Te0.80 glass alloyed with As0.40Se0.60 in different proportions. The addition of As0.40Se0.60 increases the electrical resistivity and the threshold voltage of (As0.4Se0.6)x(Ge0.2Te0.8)1-x glasses in the composition range 0 ≤ x ≤ 0.40. Glasses in the range 0 ≤ x ≤ 0.10 are found to exhibit memory switching, whereas glasses with x ≥ 0.15 exhibit threshold switching. The memory (SET) state can be brought back to RESET state by passing a current of 3-5 mA. Particularly, the glass with x = 0.10 is identified to be very stable, and it can be cycled between the SET and RESET state consistently with 3 mA current. The Raman spectra of SET and RESET states indicate that the SET sample has GeTe and Te crystalline units while the structure of RESET state is analogous to the as-quenched glass. Interestingly, the variation in the local structure is minimal for SET and RESET states for x = 0.10. And also the resistance of the SET state is relatively high. So they can be set to RESET state with less current and can be explored for low power phase change memory applications.
Sang, Nguyen Duy; Van Hung, Nguyen; Van Hung, Tran; Hien, Nguyen Quoc
2017-03-01
The kinetic parameters of thermoluminescence (TL) glow peaks of chilli powder irradiated by gamma rays with the different doses of 0, 4 and 8 kGy have been calculated and estimate by computerized glow curve deconvolution (CGCD) method and the R package tgcd by using the TL glow curve data. The kinetic parameters of TL glow peaks (i.e. activation energies (E), order of kinetics (b), trapping and recombination probability coefficients (R) and frequency factors (s)) are fitted by modeled general-orders of kinetics (GOK) and one trap-one recombination (OTOR). The kinetic parameters of the chilli powder are different toward the difference of the sample time-storage, radiation doses, GOK model and OTOR one. The samples spending the shorter period of storage time have the smaller the kinetic parameters values than the samples spending the longer period of storage. The results obtained as comparing the kinetic parameters values of the three samples show that the value of non-irradiated samples are lowest whereas the 4 kGy irradiated-samples' value are greater than the 8 kGy irradiated-samples' one time.
ZnO nanowire-based all-optical switch with Reset-Set flip-flop function
Mu, L. X.; Shi, W. S.; Zhang, T. P.; Zhang, H. Y.; Wang, Y.; She, G. W.; Gao, Y. H.; Wang, P. F.; Chang, J. C.; Lee, S. T.
2011-04-01
An all-optical switch with Reset-Set (RS) flip-flop function has been developed by attaching a derivative of spiropyran on the surface of zinc oxide (ZnO) Nanowire. Using UV/visible irradiation and the fluorescence of spiropyran-modified ZnO nanowire as inputs—set/reset and output, RS flip-flop function can be performed on a single ZnO nanowire or a nanowire array. The configuration of the current all-optical switch represents a potential for developing small-sized all-optical devices, which could be further exploited at higher level of integration.
Guo-Qing WANG; Wan-Ping SUN; Yong-Jin ZHU; Rong ZOU; Xi-Ping ZHOU
2006-01-01
Objective To investigate the role of H1 and H2 receptors in the locus ceruleus (LC) in carotid sinus baroreceptor reflex (CSR) resetting induced by intracerebroventricular (i.c.v.) injection of histamine (HA). Methods The left and right carotid sinus regions were isolated from the systemic circulation in 18 male Sprague-Dawley rats anesthetized with pentobarbital sodium. The intracarotid sinus pressure (ISP) was altered in a stepwise manner in vivo. ISP-mean arterial pressure (MAP) relationship curve and its characteristic parameters were constructed by fitting to the logistic function with five parameters. The changes in CSR performance induced by i.c.v. HA and the effects of pretreatment with H1 or H2 receptors selective antagonist, chlorpheniramine (CHL) or cimetidine (CIM) into the LC, on the responses of CSR to HA were examined. Results I.c.v. HA (100 ng in 5 μl) significantly shifted the ISP-MAP relationship curve upwards (P ＜ 0.05) and obviously decreased the value of the reflex parameters such as MAP range and maximum gain (P ＜ 0.05), but increased the threshold pressure, saturation pressure and ISP at maximum gain (P ＜ 0.05). The pretreatment with CHL (0.5 μg in 1 μl) or CIM (1.5 μg in 1 μl) into the LC could obviously attenuate the changes mentioned above in CSR performance induced by HA, but the alleviative effect of CIM was less remarkable than that ofCHL (P ＜ 0.05). Respective microinjection of CHL or CIM alone into the LC with the corresponding dose and volume did not change CSR performance significantly (P ＞ 0.05). Conclusion Intracerebroventricular administration of HA results in a rapid resetting of CSR and a decrease in reflex sensitivity, and the responses of CSR to HA may be mediated, at least in part, by H1 and H2 receptors activities in the LC, especially by H1 receptors. Moreover, the effects of the central HA on CSR might be related to a histaminergic descending pathway from the hypothalamus to LC.
Aldape U, F.; Oliver, A.; Montenegro, E.C. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)
1986-02-15
In this work it is carried out a new calibration method for an X-rays detection system for PIXE analysis. This method it bases on the parametric expression introduced by Gallaher and Cipola in which the efficiency curve is obtained adjusting the parameters that they represent the solid angle, the attenuation in the absorbers of low Z and the absorption in the sensitive region of the detector, starting from calibrated radioactive sources, in those which those ray-X emitted its are in most of E > 10 KeV. In the region E < 10 Kev, the quantity of experimental points is poor and also, due to the absorption problems, its are the points where greater experimental error is made. (Author)
Karhula, T. [Tampere Univ. of Technology (Finland)
2013-07-15
This work is part of Posiva's spent nuclear fuel disposal canister sealing development. Posiva has welded series of plate welding experiments at Patria Aviation Facilities. At Tampere University of Technology, Department of Materials Science (TUT DMS) metallographic and electron microscopy studies of electron beam welded copper samples have been carried out. In this report a part of the welding test program is analyzed. The results of the cross-sections of the test welds X436-X440 and X453-X458 are presented here together with the methods used. These two sets of welds were conducted to study the effects of welding speed, annealing temperature and the presence of cosmetic pass. The aim of this study was to estimate the residual stresses present in the EB-welds using electron backscatter diffraction (EBSD) technique. For this task various EBSD reference curves with tensile test samples were constructed: the recrystallized, substructured and deformed fractions of grains, the occurrence of 1.5 deg C and 2.5 deg C misorientations, the average of mean intra-grain misorientation AMIS, and the hardness could be related to the applied strain. It was found that the hardness was higher if there was a cosmetic pass on the weld. The welding speed and the annealing temperature did not seem to have a noticeable effect on the measured properties. The estimated residual stresses were mainly very low, in the range 27-34 MPa. In the values estimated based on the hardness reference curve, the maximum residual stress was 58.7 MPa (in X455A). (orig.)
2002-01-01
The Atlas of Stress-Strain Curves, Second Edition is substantially bigger in page dimensions, number of pages, and total number of curves than the previous edition. It contains over 1,400 curves, almost three times as many as in the 1987 edition. The curves are normalized in appearance to aid making comparisons among materials. All diagrams include metric (SI) units, and many also include U.S. customary units. All curves are captioned in a consistent format with valuable information including (as available) standard designation, the primary source of the curve, mechanical properties (including hardening exponent and strength coefficient), condition of sample, strain rate, test temperature, and alloy composition. Curve types include monotonic and cyclic stress-strain, isochronous stress-strain, and tangent modulus. Curves are logically arranged and indexed for fast retrieval of information. The book also includes an introduction that provides background information on methods of stress-strain determination, on...
Kim, Sungjun; Park, Byung-Gook
2016-12-01
A study on the bipolar-resistive switching of an Ni/SiN/Si-based resistive random-access memory (RRAM) device shows that the influences of the reset power and the resistance value of the low-resistance state (LRS) on the reset-switching transitions are strong. For a low LRS with a large conducting path, the sharp reset switching, which requires a high reset power (>7 mW), was observed, whereas for a high LRS with small multiple-conducting paths, the step-by-step reset switching with a low reset power (switching is due to the steep current-increased region of the trap-controlled space charge-limited current (SCLC) model. A multilevel cell (MLC) operation, for which the reset stop voltage (V STOP) is used in the DC sweep mode and an incremental amplitude is used in the pulse mode for the step-by-step reset switching, is demonstrated here. The results of the present study suggest that well-controlled conducting paths in a SiN-based RRAM device, which are not too strong and not too weak, offer considerable potential for the realization of low-power and high-density crossbar-array applications.
There are four natural curves in the spinal column. The cervical, thoracic, lumbar, and sacral curvature. The curves, along with the intervertebral disks, help to absorb and distribute stresses that occur from everyday activities such as walking or from ...
Janusz Charatonik
1991-11-01
Full Text Available Results concerning contractibility of curves (equivalently: of dendroids are collected and discussed in the paper. Interrelations tetween various conditions which are either sufficient or necessary for a curve to be contractible are studied.
Parametrizing Algebraic Curves
Lemmermeyer, Franz
2011-01-01
We present the technique of parametrization of plane algebraic curves from a number theorist's point of view and present Kapferer's simple and beautiful (but little known) proof that nonsingular curves of degree > 2 cannot be parametrized by rational functions.
Chaudhury, Soumini; Cowsik, Ramanath
2010-01-01
Direct detection of Weakly Interacting Massive Particle (WIMP) candidates of Dark Matter (DM) is studied within the context of a self-consistent truncated isothermal model of the finite-size dark halo of Milky Way in the light of the recent determination of the Galaxy's circular rotation curve out to 60 kpc. This new rotation curve declines with Galactocentric distance ($R$) for $R\\gsim10\\kpc$. Our Galaxy halo model takes into account the modifications of the phase-space structure of the dark matter halo due to the gravitational influence of the observed visible matter in a self-consistent manner. In contrast to the standard halo model (SHM) routinely used in analyzing the results of WIMP direct detection experiments, the velocity distribution of the WIMPs in our model is distinctly non-Maxwellian with a cut-off at a maximum velocity that is self-consistently determined by the model itself. For our halo model that provides the best fit to the new rotation curve data, the most stringent 90\\% C.L. upper limit o...
GONG Yue-Feng; LING Yun; SONG Zhi-Tang; FENG Song-Lin
2008-01-01
A three-dimensional finite element models for phase change random access memory (PCRAM) is established to simulate thermal and electrical behaviours during RESET operation. The RESET behaviours of the conventional structure (CS) and the ring-type contact in bottom electrode (RIB) are compared with each other. The simulation results indicate that the RIB cell has advantages of high heat efficiency for melting phase change material in cell,reduction of contact area and lower RESET current with maintaining good resistance contrast. The RESET current decreases from 1.26mA to 1.2mA and the heat consumption in GST material during programming increases from 12% to 37% in RIB structure. Thus the RIB structure PCRAM cell is suitable for future device with high heat efficiency and smaller RESET current.
Current mirror reset for low-power BiCMOS charge amplifier
Sampietro, M; Fasoli, L
2000-01-01
We present a circuit solution to provide DC feedback and signal reset in charge amplifiers that overcomes the difficulty to integrate high value resistors in VLSI technology. The feedback resistor is substituted by a MOSFET current conveyor that re-direct to the input node the current already available at the output follower. The lower noise of this 'active resistor' with respect to a physical resistor of equal value makes possible a first shaping within the preamplifier. The circuit has been implemented for a fast shaping time system (20 ns peaking time) using a BJT as input transistor for best noise performance. The circuit has been powered with single supply as low as 1.6 V with a total power consumption down to 220 mu W/ch and has shown a measured noise of 660 electrons rms, in accordance with the theoretical expectation.
Pixel-level A/D conversion using voltage reset technique
Li Minzeng; Li Fule; Zhang Chun; Wang Zhihua
2014-01-01
This paper presents a 50 Hz 15-bit analog-to-digital converter (ADC) for pixel-level implementation in CMOS image sensors.The ADC is based on charge packets counting and adopts a voltage reset technique to inject charge packets.The core circuit for charge/pulse conversion is specially optimized for low power,low noise and small area.An experimental chip with ten pixel-level ADCs has been fabricated and tested for verification.The measurement result shows a standard deviation of 1.8 LSB for full-scale output.The ADC has an area of 45 × 45μm2 and consumes less than 2 μW in a standard 1P-6M 0.18μm CMOS process.
Performance Analysis Of Various Anti-Reset Windup Algorithms For A Flow Process Station
Shaunak Chakrabartty
2014-05-01
Full Text Available The study was aimed to develop the various aspects of Anti reset windup or Integral windup and also the different algorithms available to eliminate the phenomenon of windup. Different open loop responses were obtained from a Flow process Station using MATLAB and SIMULINK and VI Microsystems process control software. The open loop responses were evaluated and different system models were generated using the two point method. The system models were found to follow a decreasing order of Gain values and an increasing order of Td and T values. A SIMULINK model was obtained to implement Back calculation combined with Conditional Integration. The models for the system obtained were simulated using the SIMULINK model and a PID controller and the closed loop responses were generated. The closed loop responses using a PID controller with Back calculation and Conditional integration were found to follow the set point as expected.
Power-Performance Tradeoffs in Wide Dynamic Range Image Sensors with Multiple Reset Approach
Arthur Spivak
2011-03-01
Full Text Available A variety of solutions for widening the dynamic range (DR of CMOS image sensors have been proposed throughout the years. These solutions can be categorized into different groups according to the principle used for DR widening. One of the methods, which is based on autonomous control over the integration time, was implemented by our group. We proposed the multiple resets algorithm, which was successfully implemented in three generations of WDR image sensors. While achieving the same goal of widening the DR of the sensor, each of the implemented imagers had a different architecture, and therefore presented different performance and power figures. This paper reviews designs of the aforementioned sensors and presents a comprehensive analysis of their power consumption. Power-performance tradeoffs are also discussed. Advantages and disadvantages of each sensor are presented.
Thiacalix[4]arene based reconfigurable molecular switches: set-reset memorized sequential device.
Kumar, Manoj; Kumar, Rajesh; Bhalla, Vandana
2011-12-21
The fluorescent chemosensors 3, 5 and 7 based on thiacalix[4]arene bearing naphthyl groups have been designed and synthesized. The optical chemosensor 3 based on a thiacalix[4]arene of cone conformation behaves as "turn-on" optical chemosensor for Fe(3+) and F(-) ions. However, chemosensors 5 and 7 based on a thiacalix[4]arene of 1,3-alternate conformation demonstrate "turn-on" optical behaviour for Hg(2+), F(-) ions (with receptor 5 as turn-on for K(+) ions also) and "turn-off" behaviour for Fe(3+) ions. The simultaneous presence of Fe(3+) and Hg(2+) or K(+) or F(-) ions results in formulation of reversible "on-off" switches. Various molecular logic gates developed in response to molecular switching between these chemical inputs have been integrated into sequential logic circuits with memory function in a feedback loop which mimics "set-reset" molecular level information processing device.
Outlier reset CUSUM for the exploration of copy number alteration data.
Lai, Yinglei; Gastwirth, Joseph L
2015-08-01
Copy number alteration (CNA) data have been collected to study disease related chromosomal amplifications and deletions. The CUSUM procedure and related plots have been used to explore CNA data. In practice, it is possible to observe outliers. Then, modifications of the CUSUM procedure may be required. An outlier reset modification of the CUSUM (ORCUSUM) procedure is developed in this paper. The threshold value for detecting outliers or significant CUSUMs can be derived using results for sums of independent truncated normal random variables. Bartel's non-parametric test for autocorrelation is also introduced to the analysis of copy number variation data. Our simulation results indicate that the ORCUSUM procedure can still be used even in the situation where the degree of autocorrelation level is low. Furthermore, the results show the outlier's impact on the traditional CUSUM's performance and illustrate the advantage of the ORCUSUM's outlier reset feature. Additionally, we discuss how the ORCUSUM can be applied to examine CNA data with a simulated data set. To illustrate the procedure, recently collected single nucleotide polymorphism (SNP) based CNA data from The Cancer Genome Atlas (TCGA) Research Network is analyzed. The method is applied to a data set collected in an ovarian cancer study. Three cytogenetic bands (cytobands) are considered to illustrate the method. The cytobands 11q13 and 9p21 have been shown to be related to ovarian cancer. They are presented as positive examples. The cytoband 3q22, which is less likely to be disease related, is presented as a negative example. These results illustrate the usefulness of the ORCUSUM procedure as an exploratory tool for the analysis of SNP based CNA data.
Masahiro eKawasaki
2014-03-01
Full Text Available Electroencephalogram (EEG phase synchronization analyses can reveal large-scale communication between distant brain areas. However, it is not possible to identify the directional information flow between distant areas using conventional phase synchronization analyses. In the present study, we applied transcranial magnetic stimulation (TMS to the occipital area in subjects who were resting with their eyes closed, and analyzed the spatial propagation of transient TMS-induced phase resetting by using the transfer entropy (TE, to quantify the causal and directional flow of information. The time-frequency EEG analysis indicated that the theta (5 Hz phase locking factor (PLF reached its highest value at the distant area (the motor area in this study, with a time lag that followed the peak of the transient PLF enhancements of the TMS-targeted area at the TMS onset. PPI (phase-preservation index analyses demonstrated significant phase resetting at the TMS-targeted area and distant area. Moreover, the TE from the TMS-targeted area to the distant area increased clearly during the delay that followed TMS onset. Interestingly, the time lags were almost coincident between the PLF and TE results (152 vs. 165 ms, which provides strong evidence that the emergence of the delayed PLF reflects the causal information flow. Such tendencies were observed only in the higher-intensity TMS condition, and not in the lower-intensity or sham TMS conditions. Thus, TMS may manipulate large-scale causal relationships between brain areas in an intensity-dependent manner. We demonstrated that single-pulse TMS modulated global phase dynamics and directional information flow among synchronized brain networks. Therefore, our results suggest that single-pulse TMS can manipulate both incoming and outgoing information in the TMS-targeted area associated with functional changes.
Melanopsin resets circadian rhythms in cells by inducing clock gene Period1
Yamashita, Shuhei; Uehara, Tomoe; Matsuo, Minako; Kikuchi, Yo; Numano, Rika
2014-02-01
The biochemical, physiological and behavioral processes are under the control of internal clocks with the period of approximately 24 hr, circadian rhythms. The expression of clock gene Period1 (Per1) oscillates autonomously in cells and is induced immediately after a light pulse. Per1 is an indispensable member of the central clock system to maintain the autonomous oscillator and synchronize environmental light cycle. Per1 expression could be detected by Per1∷luc and Per1∷GFP plasmid DNA in which firefly luciferase and Green Fluorescence Protein were rhythmically expressed under the control of the mouse Per1 promoter in order to monitor mammalian circadian rhythms. Membrane protein, MELANOPSIN is activated by blue light in the morning on the retina and lead to signals transduction to induce Per1 expression and to reset the phase of circadian rhythms. In this report Per1 induction was measured by reporter signal assay in Per1∷luc and Per1∷GFP fibroblast cell at the input process of circadian rhythms. To the result all process to reset the rhythms by Melanopsin is completed in single cell like in the retina projected to the central clock in the brain. Moreover, the phase of circadian rhythm in Per1∷luc cells is synchronized by photo-activated Melanopsin, because the definite peak of luciferase activity in one dish was found one day after light illumination. That is an available means that physiological circadian rhythms could be real-time monitor as calculable reporter (bioluminescent and fluorescent) chronological signal in both single and groups of cells.
2016-05-01
MILITARY READINESS DOD Needs to Incorporate Elements of a Strategic Management Planning Framework into Retrograde...Incorporate Elements of a Strategic Management Planning Framework into Retrograde and Reset Guidance Why GAO Did This Study Following the end of major...policy and (2) the services developed implementation plans consistent with leading practices on sound strategic management planning for the
Walaszczyk Juliusz
2017-01-01
Full Text Available This article addresses different duct static pressure control strategies which could be implemented in variable air volume air-conditioning systems (VAV. Two pressure reset control strategies are compared to the commonly used control solution based on the “Constant static pressure” method. First pressure reset control strategy, known as PID Control, uses signals from VAV boxes controllers to reset duct static pressure in a way that one of the VAV dampers is maintained almost entirely open. Second strategy decreases static pressure setpoint until an adjustable number of pressure requests occur. As a response to the certain amount of requests, static pressure setpoint is increased. This strategy is called Trim & Respond. Both static pressure reset control strategies described in this paper are considered to have more significant potential for energy savings than the “Constant static pressure” method. In order to validate this potential, several simulations for different control strategies were carried out and the obtained results are compared and analysed. The theoretical limit of the energy savings - set of the optimal control actions, was estimated with Nelder-Mead algorithm and also presented in this article. General description of the static pressure control strategies "Constant static pressure", PID Control and Trim & Respond is given.
Bernstein, Daniel J.; Birkner, Peter; Lange, Tanja;
2013-01-01
This paper introduces EECM-MPFQ, a fast implementation of the elliptic-curve method of factoring integers. EECM-MPFQ uses fewer modular multiplications than the well-known GMP-ECM software, takes less time than GMP-ECM, and finds more primes than GMP-ECM. The main improvements above the modular......-arithmetic level are as follows: (1) use Edwards curves instead of Montgomery curves; (2) use extended Edwards coordinates; (3) use signed-sliding-window addition-subtraction chains; (4) batch primes to increase the window size; (5) choose curves with small parameters and base points; (6) choose curves with large...
Baykara, N. A. [Marmara University, Faculty of Sciences and Letters, Mathematics Department, Göztepe Campus, 34730, Istanbul (Turkey)
2015-12-31
Recent studies on quantum evolutionary problems in Demiralp’s group have arrived at a stage where the construction of an expectation value formula for a given algebraic function operator depending on only position operator becomes possible. It has also been shown that this formula turns into an algebraic recursion amongst some finite number of consecutive elements in a set of expectation values of an appropriately chosen basis set over the natural number powers of the position operator as long as the function under consideration and the system Hamiltonian are both autonomous. This recursion corresponds to a denumerable infinite number of algebraic equations whose solutions can or can not be obtained analytically. This idea is not completely original. There are many recursive relations amongst the expectation values of the natural number powers of position operator. However, those recursions may not be always efficient to get the system energy values and especially the eigenstate wavefunctions. The present approach is somehow improved and generalized form of those expansions. We focus on this issue for a specific system where the Hamiltonian is defined on the coordinate of a curved space instead of the Cartesian one.
Kong, Eun Jung; Cho, Ihn Ho; Chun, Kyung Ah; Won, Kyu Chang; Lee, Hyung Woo; Choi, Jun Heok; Shin, Duk Seop [Yeungnam University College of Medicine, Daegu (Korea, Republic of)
2007-12-15
We evaluated the standard uptake value (SUV) of F-18 FDG at PET/CT for differentiation of benign from malignant tumor in primary musculoskeletal tumors. Forty-six tumors (11 benign and 12 malignant soft tissue tumors, 9 benign and 14 malignant bone tumors) were examined with F-18 FDG PET/CT (Discovery ST, GE) prior to tissue diagnosis. The maxSUV(maximum value of SUV) were calculated and compared between benign and malignant lesions. The lesion analysis was based on the transverse whole body image. The maxSUV with cutoff of 4.1 was used in distinguishing benign from malignant soft tissue tumor and 3.05 was used in bone tumor by ROC curve. There was a statistically significant difference in maxSUV between benign (n = 11; maxSUV 3.4 {+-} 3.2) and malignant (n = 12; maxSUV 14.8 {+-} 12.2) lesion in soft tissue tumor ({rho} = 0.001). Between benign bone tumor (n = 9; maxSUV 5.4 {+-} 4.0) and malignant bone tumor (n = 14; maxSUV 7.3 {+-} 3.2), there was not a significant difference in maxSUV. The sensitivity and specificity for differentiating malignant from benign soft tissue tumor was 83% and 91%, respectively. There were four false positive malignant bone tumor cases to include fibrous dysplasia, Langerhans-cell histiocytosis (n = 2) and osteoid osteoma. Also, one false positive case of malignant soft tissue tumor was nodular fasciitis. The maxSUV was useful for differentiation of benign from malignant lesion in primary soft tissue tumors. In bone tumor, the low maxSUV correlated well with benign lesions but high maxSUV did not always mean malignancy.
Hopwood, J.
1978-02-01
A microprocessor-based, stored-program controller which incorporates a floating-point arithmetic unit to perform complex mathematical computations was developed to determine the thickness of conductors on printed wiring boards. Conductor thickness is calculated from measured resistance by means of curve-fitting equations in the stored program. Called a film thickness calculator, the instrument demonstrates a method which may serve as a basis for other designs involving microprocessor-based data acquisition systems requiring low-speed calculations. 19 figures.
Coppens, Marc
2011-01-01
We consider coverings of real algebraic curves to real rational algebraic curves. We show the existence of such coverings having prescribed topological degree on the real locus. From those existence results we prove some results on Brill-Noether Theory for pencils on real curves. For coverings having topological degree 0 we introduce the covering number k and we prove the existence of coverings of degree 4 with prescribed covering number.
René Pellissier
2012-01-01
Full Text Available This paper explores the notion ofjump ing the curve,following from Handy 's S-curve onto a new curve with new rules policies and procedures. . It claims that the curve does not generally lie in wait but has to be invented by leadership. The focus of this paper is the identification (mathematically and inferentially ofthat point in time, known as the cusp in catastrophe theory, when it is time to change - pro-actively, pre-actively or reactively. These three scenarios are addressed separately and discussed in terms ofthe relevance ofeach.
Accessing probable thermal histories through dispersed, partially-reset zircon (U-Th)/He ages
Powell, Jeremy; Schneider, David
2016-04-01
We have applied the ZRDAAM model (Guenthner et al., 2013; Am. J. Sci. 313) to assess the thermal evolution of the Neoproterozoic stratigraphy of the Mackenzie Mountain fold-thrust belt (NWT, Canada), which witnessed protracted (100's m.y.) cooling through the uppermost crust. Single crystal ZHe dates from rocks in the cores of anticlines span 432 ± 35 Ma to 46 ± 4 Ma, with intrasample ZHe date dispersion as great as 350 m.y., indicating that the strata have not been heated sufficiently to fully reset the zircon (U-Th)/He system. The modeling has its most utility in samples where self-irradiation of zircon has occurred over long geologic timescales without significant annealing of damaged zones. Partially- to fully-reset detrital datasets can contain a tremendous amount of T-t information, due to the wide range in grain size, eU, and potential for variable pre-depositional histories and inherited radiation damage in the zircon population. These variables result in a broad spectrum of closure temperatures within a single sample, and in tectonic settings where strata are never buried to sufficiently high temperatures can potentially record more than the most recent thermal event. Additionally, modeling of these datasets has added value in strata where apatite is absent or too small for (U-Th)/He analysis, as highly damaged zircon can record similar parts of the cooling history as the apatite He system. However, several factors complicate interpretation of these datasets including the influences of pre-depositional history (e.g. inherited 4He and radiation damage, on ZHe dates and date-eU relationships). As a result of these variables, sampling from the same stratigraphic succession can yield substantially different ZHe date populations, despite having experienced the same T-t history, should the strata have different grain sizes or provenance. For these reasons, we believe that detailed thermal modeling is required to understand the probable geologic history
Glickman, G L; Harrison, E M; Elliott, J A; Gorman, M R
2014-03-01
Light regulates a variety of behavioral and physiological processes, including activity rhythms and hormone secretory patterns. Seasonal changes in the proportion of light in a day (photoperiod) further modulate those functions. Recently, short (SP) versus long days (LP) were found to markedly increase light sensitivity for phase shifting in Syrian hamsters. To our knowledge, photoperiod effects on light sensitivity have not been studied in other rodents, nor is it known if they generalize to other circadian responses. We tested whether photic phase shifting and melatonin suppression vary in Siberian hamsters maintained under LP or SP. Select irradiances of light were administered, and shifts in activity were determined. Photic sensitivity for melatonin suppression was examined in a separate group of animals via pulses of light across a 4 log-unit photon density range, with post-pulse plasma melatonin levels determined via RIA. Phase shifting and melatonin suppression were greater at higher irradiances for both LP and SP. The lower irradiance condition was below threshold for phase shifts in LP but not SP. Melatonin suppression did not vary by photoperiod, and the half saturation constant for fitted sigmoid curves was similar under LP and SP. Thus, the photoperiodic modulation of light sensitivity for phase shifting is conserved across two hamster genera. The dissociation of photoperiod effects on photic phase shifting and melatonin suppression suggests that the modulation of sensitivity occurs downstream of the common retinal input pathway. Understanding the mechanistic basis for this plasticity may yield therapeutic targets for optimizing light therapy practices.
Simulating Supernova Light Curves
Even, Wesley Paul [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dolence, Joshua C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
2016-05-05
This report discusses supernova light simulations. A brief review of supernovae, basics of supernova light curves, simulation tools used at LANL, and supernova results are included. Further, it happens that many of the same methods used to generate simulated supernova light curves can also be used to model the emission from fireballs generated by explosions in the earth’s atmosphere.
Tempo curves considered harmful
Desain, P.; Honing, H.
1993-01-01
In the literature of musicology, computer music research and the psychology of music, timing or tempo measurements are mostly presented in the form of continuous curves. The notion of these tempo curves is dangerous, despite its widespread use, because it lulls its users into the false impression th
Pairings on hyperelliptic curves
Balakrishnan, Jennifer; Chisholm, Sarah; Eisentraeger, Kirsten; Stange, Katherine; Teske, Edlyn
2009-01-01
We assemble and reorganize the recent work in the area of hyperelliptic pairings: We survey the research on constructing hyperelliptic curves suitable for pairing-based cryptography. We also showcase the hyperelliptic pairings proposed to date, and develop a unifying framework. We discuss the techniques used to optimize the pairing computation on hyperelliptic curves, and present many directions for further research.
Andreas Chai; Alessio Moneta
2010-01-01
..., Professor of Economics, University of Illinois, Chicago, at jpersky@uic.edu jpersky@uic.edu.. Introduction Introduction Engel curves describe how household expenditure on particular goods or Engel curves describe how household expenditure on particular goods or services depends on household income. The name comes from the German st...
Martínez, Sol Sáez; de la Rosa, Félix Martínez; Rojas, Sergio
2017-01-01
In Advanced Calculus, our students wonder if it is possible to graphically represent a tornado by means of a three-dimensional curve. In this paper, we show it is possible by providing the parametric equations of such tornado-shaped curves.
Chou, Kai-Seng
2001-01-01
Although research in curve shortening flow has been very active for nearly 20 years, the results of those efforts have remained scattered throughout the literature. For the first time, The Curve Shortening Problem collects and illuminates those results in a comprehensive, rigorous, and self-contained account of the fundamental results.The authors present a complete treatment of the Gage-Hamilton theorem, a clear, detailed exposition of Grayson''s convexity theorem, a systematic discussion of invariant solutions, applications to the existence of simple closed geodesics on a surface, and a new, almost convexity theorem for the generalized curve shortening problem.Many questions regarding curve shortening remain outstanding. With its careful exposition and complete guide to the literature, The Curve Shortening Problem provides not only an outstanding starting point for graduate students and new investigations, but a superb reference that presents intriguing new results for those already active in the field.
Iglesias Rey, P. L.; Martinez Solano, F. J.; Fuertes Miquel, V. S.; Lopez Patino, G.
2007-07-01
A new water inlet point in the network can modify the water supply schedule so that the distribution of flow to supply from the different points would be a problem to determine in each case. To present work uses the reference curve concept of a water supply system to propose a method that determines the appropriate distribution of water supplied using simulation models. The methodology is based on looking for the grater power efficiency in the system, assuming equal production costs in the different sources. The obtained conclusions allows to know some parameters that influence in the location of the optimal production system. At the same time, the analysis of two examples shows the reach of the propose methodology. (Author) 6 refs.
Slyusarenko, Kostyantyn; Abécassis, Benjamin; Davidson, Patrick; Constantin, Doru
2014-10-01
UV-Vis absorption spectroscopy is frequently used to characterize the size and shape of gold nanoparticles. We present a full-spectrum model that yields reliable results for the commonly encountered case of mixtures of spheres and rods in varying proportions. We determine the volume fractions of the two populations, the aspect ratio distribution of the nanorods (average value and variance) and the interface damping parameter. We validate the model by checking the fit results against small-angle X-ray scattering and transmission electron microscopy data and show that correctly accounting for the polydispersity in aspect ratio is essential for a quantitative description of the longitudinal plasmon peak.UV-Vis absorption spectroscopy is frequently used to characterize the size and shape of gold nanoparticles. We present a full-spectrum model that yields reliable results for the commonly encountered case of mixtures of spheres and rods in varying proportions. We determine the volume fractions of the two populations, the aspect ratio distribution of the nanorods (average value and variance) and the interface damping parameter. We validate the model by checking the fit results against small-angle X-ray scattering and transmission electron microscopy data and show that correctly accounting for the polydispersity in aspect ratio is essential for a quantitative description of the longitudinal plasmon peak. Electronic supplementary information (ESI) available: TEM images of nanoparticles and detailed analysis, simplified relations for the AS model, alternative estimate for the concentration and discussion of the dielectric constant chosen for bulk gold. See DOI: 10.1039/c4nr04155k
The Impact of the Combination of Circular Curve and Transition Curve on Highway Operation Security
Cao Youlu
2015-07-01
Full Text Available By investigating the accident in 2009 and 2011 of Taijiu Expressway, the study analyzed the relationship between the horizontal curve radiuses, the length of horizontal curve, the length of transition curve and the number of accidents, established the corresponding regression model. The trend of accidents was determined with different length of transition curve and different combination of circular curve according to this model. The results show that the circular curve radius and length of transition curve increase with the decreases of accidents number, the number of accidents decreases with the increase of the ratio of the length of the transition curve and the length of the round curve. When the ratio of the parameters of the transition curve and the radius of the circle is between 0.3-0.6, the accidents are more focused. The bigger change rate of curves is, there are more accidents of flat curve. To evaluate road traffic safety from the perspective of horizontal curve alignment design, these regularities have very important reference.
A novel pulse processing scheme using embedded pulsed reset charge sensitive preamplifier
Prasanna, G.; Jayapandian, J.; Sheela, O. K.; Amarendra, G.
2016-05-01
A novel, cost effective pulse height digitization scheme for spectroscopy applications, utilizing a CMOS analog switch as reset element in the feedback of preamplifier stage is designed. The CMOS switch resistance is controlled by a signal generated from a firmware, run in parallel with a digitizer. While the very high open-state resistance of the switch reduces the thermal noise in the preamplifier output, eliminating the need for pulse shaping, it increases the probability of pulse pile-up. A state machine run in conjunction with the firmware eliminates the pile-up event error contribution by prompting the firmware to prevent the piled-up pulse levels from getting registered. The Pulse height digitization and pile up elimination functions are implemented on a single-chip Programmable System on Chip (PSoC) mixed signal platform from Cypress Semiconductor. The digitized pulse heights are communicated to a PC based virtual instrument graphical user interface developed using National Instruments Lab VIEW. The new scheme is functionally verified with Planar PIN diode detectors in obtaining alpha particle spectra.
D'Antonio, Maurizio; Musner, Nicolò; Scapin, Cristina; Ungaro, Daniela; Del Carro, Ubaldo; Ron, David; Feltri, M Laura; Wrabetz, Lawrence
2013-04-01
P0 glycoprotein is an abundant product of terminal differentiation in myelinating Schwann cells. The mutant P0S63del causes Charcot-Marie-Tooth 1B neuropathy in humans, and a very similar demyelinating neuropathy in transgenic mice. P0S63del is retained in the endoplasmic reticulum of Schwann cells, where it promotes unfolded protein stress and elicits an unfolded protein response (UPR) associated with translational attenuation. Ablation of Chop, a UPR mediator, from S63del mice completely rescues their motor deficit and reduces active demyelination by half. Here, we show that Gadd34 is a detrimental effector of CHOP that reactivates translation too aggressively in myelinating Schwann cells. Genetic or pharmacological limitation of Gadd34 function moderates translational reactivation, improves myelination in S63del nerves, and reduces accumulation of P0S63del in the ER. Resetting translational homeostasis may provide a therapeutic strategy in tissues impaired by misfolded proteins that are synthesized during terminal differentiation.
Sanderson, D. C. W.; Bishop, P.; Stark, M. T.; Spencer, J. Q.
2003-05-01
This paper presents a case study in the analysis of anthropogenically reset sedimentary materials, through work undertaken to identify and date sediments in an ancient canal in the Mekong Delta, Cambodia. The emergence of rice cultivating communities, utilising canals for both hydraulic management and transport, represents an important stage in the social evolution of southeast Asia. The emergence of complex polities in the region, which may have depended on both international trade and intensified agriculture, led ultimately to the formation of the famous Khmer empires which dominated the region on several occasions through the 1st and 2nd millennia AD. French colonial scholars identified possibly ancient canals in the region that may have played roles in trade, agriculture, or both. This series of ancient canal features near Angkor Borei has been the subject of recent investigations in a collaboration between the Universities of Glasgow and Hawaii. Luminescence profiling measurements were used to identify the canal bed, by exploiting the contrast between a regional substrate of some 50 ka depositional age and more recent archaeological sediments. In this manner it has been possible to identify the sedimentary substrate, undisturbed canal sediments, and redeposited material. Ages have been estimated for substrate and canal infill sediments. The work represents the first convincing demonstration of luminescence dating of one of these important regional features, and indeed the first confirmation of the presumed antiquity of the canal system around Angkor Borei.
Penny J Tricker
2015-09-01
Full Text Available The transgenerational inheritance of stress-induced epigenetic modifications is still controversial. Despite several examples of defence ‘priming’ and induced genetic rearrangements, the involvement and persistence of transgenerational epigenetic modifications is not known to be general. Here I argue that non-transmission of epigenetic marks through meiosis may be regarded as an epigenetic modification in itself, and that we should understand the implications for plant evolution in the context of both selection for and selection against transgenerational epigenetic memory. Recent data suggest that both epigenetic inheritance and resetting are mechanistically directed and targeted. Stress-induced epigenetic modifications may buffer against DNA sequence-based evolution to maintain plasticity, or may form part of plasticity’s adaptive potential. To date we have tended to concentrate on the question of whether and for how long epigenetic memory persists. I argue that we should now re-direct our question to investigate the differences between where it persists and where it does not, to understand the higher order evolutionary methods in play and their contribution.
Coordinated reset stimulation in a large-scale model of the STN-GPe circuit
Martin eEbert
2014-11-01
Full Text Available Synchronization of populations of neurons is a hallmark of several brain diseases. Coordinated reset (CR stimulation is a model-based stimulation technique which specifically counteracts abnormal synchrony by desynchronization. Electrical CR stimulation, e.g. for the treatment of Parkinson’s disease (PD, is administered via depth electrodes. In order to get a deeper understanding of this technique, we extended the top-down approach of previous studies and constructed a large-scale computational model of the respective brain areas. Furthermore, we took into account the spatial anatomical properties of the simulated brain structures and incor- porated a detailed numerical representation of 2·104 simulated neurons. We simulated the subthalamic nucleus (STN and the globus pallidus externus (GPe. Connections within the STN were governed by spike-timing dependent plasticity (STDP. In this way, we modeled the physiological and pathological activity of the considered brain structures. In particular, we investigated how plasticity could be exploited and how the model could be shifted from strongly synchronized (pathological activity to strongly desynchronized (healthy activity of the neuronal populations via CR stimulation of the STN neurons. Furthermore, we investigated the impact of specific stimulation parameters especially the electrode position on the stimulation outcome. Our model provides a step forward towards a biophysically realistic model of the brain areas relevant to the emergence of pathological neuronal activity in PD. Furthermore, our model constitutes a test bench for the optimization of both stimulation parameters and novel electrode geometries for efficient CR stimulation.
Stochastic phase resetting of two coupled phase oscillators stimulated at different times
Tass, Peter A.
2003-05-01
A model of two coupled phase oscillators is presented, where the oscillators are subject to random forces and are stimulated at different times. Transient phase dynamics, synchronization, and desynchronization, which are stimulus locked (i.e., tightly time locked to a repetitively administered stimulus), are investigated. Complex coordinated responses, in terms of a noise-induced switching across trials between qualitatively different responses, may occur when the two oscillators are reset close to an unstable fixed point of their relative phases. This can be achieved with an appropriately chosen delay between the two stimuli. The switching of the responses shows up as a coordinated cross-trial (CT) response clustering of the oscillators, where the two oscillators produce two different pairs of responses. By varying noise amplitude and coupling strength we observe a stochastic resonance and a coupling-mediated resonance of the CT response clustering, respectively. The presented data analysis method makes it possible to detect such processes in numerical and experimental signals. Its time resolution is enormous, since it is only restricted by the time resolution of the preprocessing necessary for extracting the phases from experimental data. In contrast, standard data analysis tools applied across trials relative to stimulus onset, such as CT averaging (where an ensemble of poststimulus responses is simply averaged), CT standard deviation, and CT cross correlation, fail in detecting complex coordinated responses and lead to severe misinterpretations and artifacts. The consequences for the analysis of evoked responses in medicine and neuroscience are significant and are discussed in detail.
High amplitude phase resetting in rev-erbalpha/per1 double mutant mice.
Corinne Jud
Full Text Available Over time, organisms developed various strategies to adapt to their environment. Circadian clocks are thought to have evolved to adjust to the predictable rhythms of the light-dark cycle caused by the rotation of the Earth around its own axis. The rhythms these clocks generate persist even in the absence of environmental cues with a period of about 24 hours. To tick in time, they continuously synchronize themselves to the prevailing photoperiod by appropriate phase shifts. In this study, we disrupted two molecular components of the mammalian circadian oscillator, Rev-Erbalpha and Period1 (Per1. We found that mice lacking these genes displayed robust circadian rhythms with significantly shorter periods under constant darkness conditions. Strikingly, they showed high amplitude resetting in response to a brief light pulse at the end of their subjective night phase, which is rare in mammals. Surprisingly, Cry1, a clock component not inducible by light in mammals, became slightly inducible in these mice. Taken together, Rev-Erbalpha and Per1 may be part of a mechanism preventing drastic phase shifts in mammals.
Channel Narrowing and Channel Reset: Effects of a Large Flood on the Vegetated, Narrowing Rio Grande
Dean, D. J.; Schmidt, J. C.
2009-12-01
In September 2008, heavy precipitation from a tropical storm in the Sierra Madre Occidental, MX, produced large amounts of stream flow to the Rio Conchos and lower Rio Grande. This flood was well publicized in the media due to the widespread flooding in Ojinaga, Chih., and Presidio, TX. Gage records indicate that this flood had an approximate recurrence of 15 years as measured on the Rio Grande near Presidio. Nevertheless, flood stages were the highest ever recorded and resulted from a significant loss of channel capacity due to channel narrowing that had occurred during the previous 18 years. Measurements from aerial photographs indicate that channel width had decreased between 35 and 50% between 1990 and 2008 during regional drought. During this period of low stream flow, invasion by non-native riparian vegetation (Tamarix spp., Arundo donax) helped trap sediment and promote floodplain accretion. Our resurveys of the channel indicate that the 2008 flood was a reset event and that the channel was re-widened by 32 to 48%. Repeated, oblique photographs showed significant channel migration and large scale floodplain stripping during this flood. These results show that although riparian vegetation may actively promote channel narrowing and floodplain accretion, moderately large floods may cause large scale bank erosion, floodplain stripping, and vegetation removal in alluvial valleys subject to large-scale invasion by nonnative plants.
Deng, Shijie; Morrison, Alan P
2012-09-15
This Letter presents an active quench-and-reset circuit for Geiger-mode avalanche photodiodes (GM-APDs). The integrated circuit was fabricated using a conventional 0.35 μm complementary metal oxide semiconductor process. Experimental results show that the circuit is capable of linearly setting the hold-off time from several nanoseconds to microseconds with a resolution of 6.5 ns. This allows the selection of the optimal afterpulse-free hold-off time for the GM-APD via external digital inputs or additional signal processing circuitry. Moreover, this circuit resets the APD automatically following the end of the hold-off period, thus simplifying the control for the end user. Results also show that a minimum dead time of 28.4 ns is achieved, demonstrating a saturated photon-counting rate of 35.2 Mcounts/s.
Spectral Curves of Operators with Elliptic Coefficients
J. Chris Eilbeck
2007-03-01
Full Text Available A computer-algebra aided method is carried out, for determining geometric objects associated to differential operators that satisfy the elliptic ansatz. This results in examples of Lamé curves with double reduction and in the explicit reduction of the theta function of a Halphen curve.
Modeling Start Curves of Bainite Formation
Van Bohemen, S.M.C.
2009-01-01
It is demonstrated that calculations with a physically based model give an accurate description of the start curve of bainite formation in a wide range of steels. The temperature dependence of the overall kinetics, which determines the characteristic C shape of the start curve, is controlled by both
2017-03-01
damper position as an indication of system cooling load and sets a target of 90% to 95% Open for the maximum damper in the system (Point “A” to Point...building types with different DDC systems . The demonstration results are reasonable because, in theory , the TTR would save somewhat less energy than...Graphic #2 In theory , static pressure reset strategy should work if HVAC system design is done properly and system operations run as intended. All zones
Moreno, Isabel María; Herrador, M Ángeles; Atencio, Loyda; Puerto, María; González, A Gustavo; Cameán, Ana María
2011-02-01
The aim of this study was to evaluate whether the enzyme-linked immunosorbent assay (ELISA) anti-Adda technique could be used to monitor free microcystins (MCs) in biological samples from fish naturally exposed to toxic cyanobacteria by using receiver operating characteristic (ROC) curve software to establish an optimal cut-off value for MCs. The cut-off value determined by ROC curve analysis in tench (Tinca tinca) exposed to MCs under laboratory conditions by ROC curve analysis was 5.90-μg MCs/kg tissue dry weight (d.w.) with a sensitivity of 93.3%. This value was applied in fish samples from natural ponds (Extremadura, Spain) in order to asses its potential MCs bioaccumulation by classifying samples as either true positive (TP), false positive (FP), true negative (TN), or false negative (FN). In this work, it has been demonstrated that toxic cyanobacteria, mainly Microcystis aeruginosa, Aphanizomenon issatchenkoi, and Anabaena spiroides, were present in two of these ponds, Barruecos de Abajo (BDown) and Barruecos de Arriba (BUp). The MCs levels were detected in waters from both ponds with an anti-MC-LR ELISA immunoassay and were of similar values (between 3.8-6.5-μg MC-LR equivalent/L in BDown pond and 4.8-6.0-μg MC-LR equivalent/L in BUp). The MCs cut-off values were applied in livers from fish collected from these two ponds using the ELISA anti-Adda technique. A total of 83% of samples from BDown pond and only 42% from BUp were TP with values of free MCs higher than 8.8-μg MCs/kg tissue (d.w.).
Paulo Prochno
2004-07-01
Full Text Available Learning curves have been studied for a long time. These studies provided strong support to the hypothesis that, as organizations produce more of a product, unit costs of production decrease at a decreasing rate (see Argote, 1999 for a comprehensive review of learning curve studies. But the organizational mechanisms that lead to these results are still underexplored. We know some drivers of learning curves (ADLER; CLARK, 1991; LAPRE et al., 2000, but we still lack a more detailed view of the organizational processes behind those curves. Through an ethnographic study, I bring a comprehensive account of the first year of operations of a new automotive plant, describing what was taking place on in the assembly area during the most relevant shifts of the learning curve. The emphasis is then on how learning occurs in that setting. My analysis suggests that the overall learning curve is in fact the result of an integration process that puts together several individual ongoing learning curves in different areas throughout the organization. In the end, I propose a model to understand the evolution of these learning processes and their supporting organizational mechanisms.
LI Chun-xi; CHEN Chang-jia
2009-01-01
Conventionally, P2P video is regarded as CBR traffic. However, our measurements have shown that the rate reset cannot be neglected in a practical IPTV system because each rate reset often leads to performance degradation. Thus, addressing the problem of inferring playback rate and rate reset in a P2P video system is significant. In this article, an algorithm termed piecewise linear envelope approximation (PLEA) is proposed, in which a follow-up time is introduced to smooth rate fluctuations in a small time scale and to adapt rate jumps in a large time scale automatically. With the PLEA algorithm, discontinuity introduced by blind segmentations adopted by current methods is avoided. Furthermore, unlike existing algorithms in which both segmentation and combinations are performed in multiple runs, only a single computation path is involved in the PLEA algorithm. This makes PLEA algorithm amenable to implementation of low complexity by either software or hardware. Both theoretical analysis and experiment based on measured data show that the PLEA outperforms existing algorithms based on segmentation.
Wu, Tao; Watanabe, Hiroshi; Hong, Lee Kian; Abe, Keiichi; Ni, Yinhua; Fu, Zhengwei
2011-03-01
BRAND's Essence of Chicken (BEC) has been widely used as a traditional remedy by people in Southeast Asia, which is proved to have an effect on the central nervous system (CNS) and autonomic nervous system (ANS). However, whether and how BEC consumption may affect mammalian circadian system is still largely unknown. In the present study, we investigated the effect of BEC feeding on the adaptation of circadian clocks to the experimental jet lag in rats. After the 12-h experimental jet lag through extending the light period, BEC feeding markedly facilitated the re-entrainment of all examined clock genes (Bmal1, Cry1, Per1, and Per2) in the pineal gland. The resetting time course of pineal clock genes was reduced from 7 days to only 3-5 days by BEC feeding, which was almost equal to the effect of melatonin feeding. In the liver clock, the facilitating effect of BEC feeding was mainly displayed in the re-entrainment of Bmal1 and Per2 by shortening their resetting processes for nearly 2 days. However, the resetting rate of locomotor activity rhythm was not affected by BEC feeding, suggesting that BEC might be unable to affect the behavioral rhythm.
Research on physical shape preserving curve reconstruction
TANG Kelun; ZHANG Xiangwei; CHENG Siyuan; XIONG Hanwei; ZHANG Hong
2007-01-01
Fusion of various data is an effective way to improve the precision and efficiency of acquiring information in reverse engineering.A method of physical shape preserving curve reconstruction is proposed to better realize the data fusion of coordinate measuring machine (CMM) and visual information.From the principle of materials mechanics,the strain energy of the curve corresponding to the distortion is advanced as the internal energy,and the elastic potential energy of the curve is established,using a few precise measured data points as the equilibrium position,to be the external energy.On the basis of the principle of variation calculus,the basic spline finite element method (B-spline FEM) is used to determine the equilibrium position of curve deformation.Numerical simulation indicates that there is an extremely good agreement between the new fitted curve and the actual curve.
Aoi, Shinya; Ogihara, Naomichi; Funato, Tetsuro; Sugimoto, Yasuhiro; Tsuchiya, Kazuo
2010-01-01
The central pattern generators (CPGs) in the spinal cord strongly contribute to locomotor behavior. To achieve adaptive locomotion, locomotor rhythm generated by the CPGs is suggested to be functionally modulated by phase resetting based on sensory afferent or perturbations. Although phase resetting has been investigated during fictive locomotion in cats, its functional roles in actual locomotion have not been clarified. Recently, simulation studies have been conducted to examine the roles of...
The soil reference shrinkage curve
Chertkov, V Y
2014-01-01
A recently proposed model showed how a clay shrinkage curve is transformed to the soil shrinkage curve at the soil clay content higher than a critical one. The objective of the present work was to generalize this model to the soil clay content lower a critical one. I investigated (i) the reference shrinkage curve, that is, one without cracks; (ii) the superficial layer of aggregates, with changed pore structure compared with the intraaggregate matrix; and (iii) soils with sufficiently low clay content where there are large pores inside the intraaggregate clay (so-called lacunar pores). The methodology is based on detail accounting for different contributions to the soil volume and water content during shrinkage. The key point is the calculation of the lacunar pore volume variance at shrinkage. The reference shrinkage curve is determined by eight physical soil parameters: (1) oven-dried specific volume; (2) maximum swelling water content; (3) mean solid density; (4) soil clay content; (5) oven-dried structural...
U.S. Environmental Protection Agency — an UV calibration curve for SRHA quantitation. This dataset is associated with the following publication: Chang, X., and D. Bouchard. Surfactant-Wrapped Multiwalled...
Sutawanir Darwis
2012-05-01
Full Text Available Empirical decline curve analysis of oil production data gives reasonable answer in hyperbolic type curves situations; however the methodology has limitations in fitting real historical production data in present of unusual observations due to the effect of the treatment to the well in order to increase production capacity. The development ofrobust least squares offers new possibilities in better fitting production data using declinecurve analysis by down weighting the unusual observations. This paper proposes a robustleast squares fitting lmRobMM approach to estimate the decline rate of daily production data and compares the results with reservoir simulation results. For case study, we usethe oil production data at TBA Field West Java. The results demonstrated that theapproach is suitable for decline curve fitting and offers a new insight in decline curve analysis in the present of unusual observations.
Large Curved Surface Measurement
无
2002-01-01
The measurement principle of large curved surface through theodolite industry survey system is introduced. Two methods are suggested with respect to the distribution range of curved surface error. The experiments show that the measurement precision can be up to 0.15mm with relative precision of 3×10-5. Finally, something needed paying attention to and the application aspects on theodolite industry survey system are given.
2015-01-01
In this paper we consider an elementary, and largely unexplored, combinatorial problem in low-dimensional topology. Consider a real 2-dimensional compact surface $S$, and fix a number of points $F$ on its boundary. We ask: how many configurations of disjoint arcs are there on $S$ whose boundary is $F$? We find that this enumerative problem, counting curves on surfaces, has a rich structure. For instance, we show that the curve counts obey an effective recursion, in the general framework of to...
无
2010-01-01
This is the note for a series of lectures that the author gave at the Centre de Recerca Matemtica (CRM), Bellaterra, Barcelona, Spain on October 19–24, 2009. The aim is to give a comprehensive description of some recent work of the author and his students on generalisations of the Gross-Zagier formula, Euler systems on Shimura curves, and rational points on elliptic curves.
Aoi, Shinya; Ogihara, Naomichi; Funato, Tetsuro; Sugimoto, Yasuhiro; Tsuchiya, Kazuo
2010-05-01
The central pattern generators (CPGs) in the spinal cord strongly contribute to locomotor behavior. To achieve adaptive locomotion, locomotor rhythm generated by the CPGs is suggested to be functionally modulated by phase resetting based on sensory afferent or perturbations. Although phase resetting has been investigated during fictive locomotion in cats, its functional roles in actual locomotion have not been clarified. Recently, simulation studies have been conducted to examine the roles of phase resetting during human bipedal walking, assuming that locomotion is generated based on prescribed kinematics and feedback control. However, such kinematically based modeling cannot be used to fully elucidate the mechanisms of adaptation. In this article we proposed a more physiologically based mathematical model of the neural system for locomotion and investigated the functional roles of phase resetting. We constructed a locomotor CPG model based on a two-layered hierarchical network model of the rhythm generator (RG) and pattern formation (PF) networks. The RG model produces rhythm information using phase oscillators and regulates it by phase resetting based on foot-contact information. The PF model creates feedforward command signals based on rhythm information, which consists of the combination of five rectangular pulses based on previous analyses of muscle synergy. Simulation results showed that our model establishes adaptive walking against perturbing forces and variations in the environment, with phase resetting playing important roles in increasing the robustness of responses, suggesting that this mechanism of regulation may contribute to the generation of adaptive human bipedal locomotion.
Highly curved microchannel plates
Siegmund, O. H. W.; Cully, S.; Warren, J.; Gaines, G. A.; Priedhorsky, W.; Bloch, J.
1990-01-01
Several spherically curved microchannel plate (MCP) stack configurations were studied as part of an ongoing astrophysical detector development program, and as part of the development of the ALEXIS satellite payload. MCP pairs with surface radii of curvature as small as 7 cm, and diameters up to 46 mm have been evaluated. The experiments show that the gain (greater than 1.5 x 10 exp 7) and background characteristics (about 0.5 events/sq cm per sec) of highly curved MCP stacks are in general equivalent to the performance achieved with flat MCP stacks of similar configuration. However, gain variations across the curved MCP's due to variations in the channel length to diameter ratio are observed. The overall pulse height distribution of a highly curved surface MCP stack (greater than 50 percent FWHM) is thus broader than its flat counterpart (less than 30 percent). Preconditioning of curved MCP stacks gives comparable results to flat MCP stacks, but it also decreases the overall gain variations. Flat fields of curved MCP stacks have the same general characteristics as flat MCP stacks.
Bird, John D; Jaquet, Byron M; Cowan, John W
1951-01-01
Results are presented of a wind-tunnel investigation made to determine the influence of the fuselage and tail surfaces on the rotary derivatives in yawing flight of a transonic-airplane configuration having 45 degrees sweptback wing and tail surfaces. The tests were run in the curved-flow test section of the Langley stability tunnel at a Reynolds number of 1.07 X 10 to the sixth power and consisted of balance measurements throughout the angle-of-attack range for several flight-path radii of curvature. The results are compared with data from forced-oscillation and free-oscillation tests, and a description of testing techniques used is included.
Transmission of wave energy in curved ducts
Rostafinski, W.
1973-01-01
A formation of wave energy flow was developed for motion in curved ducts. A parametric study over a range of frequencies determined the ability of circular bends to transmit energy for the case of perfectly rigid walls.
Anti-kindling Induced by Two-Stage Coordinated Reset Stimulation with Weak Onset Intensity
Zeitler, Magteld; Tass, Peter A.
2016-01-01
Abnormal neuronal synchrony plays an important role in a number of brain diseases. To specifically counteract abnormal neuronal synchrony by desynchronization, Coordinated Reset (CR) stimulation, a spatiotemporally patterned stimulation technique, was designed with computational means. In neuronal networks with spike timing–dependent plasticity CR stimulation causes a decrease of synaptic weights and finally anti-kindling, i.e., unlearning of abnormally strong synaptic connectivity and abnormal neuronal synchrony. Long-lasting desynchronizing aftereffects of CR stimulation have been verified in pre-clinical and clinical proof of concept studies. In general, for different neuromodulation approaches, both invasive and non-invasive, it is desirable to enable effective stimulation at reduced stimulation intensities, thereby avoiding side effects. For the first time, we here present a two-stage CR stimulation protocol, where two qualitatively different types of CR stimulation are delivered one after another, and the first stage comes at a particularly weak stimulation intensity. Numerical simulations show that a two-stage CR stimulation can induce the same degree of anti-kindling as a single-stage CR stimulation with intermediate stimulation intensity. This stimulation approach might be clinically beneficial in patients suffering from brain diseases characterized by abnormal neuronal synchrony where a first treatment stage should be performed at particularly weak stimulation intensities in order to avoid side effects. This might, e.g., be relevant in the context of acoustic CR stimulation in tinnitus patients with hyperacusis or in the case of electrical deep brain CR stimulation with sub-optimally positioned leads or side effects caused by stimulation of the target itself. We discuss how to apply our method in first in man and proof of concept studies. PMID:27242500
Anti-kindling induced by two-stage coordinated reset stimulation with weak onset intensity
Magteld eZeitler
2016-05-01
Full Text Available Abnormal neuronal synchrony plays an important role in a number of brain diseases. To specifically counteract abnormal neuronal synchrony by desynchronization, Coordinated Reset (CR stimulation, a spatiotemporally patterned stimulation technique, was designed with computational means. In neuronal networks with spike timing–dependent plasticity CR stimulation causes a decrease of synaptic weights and finally anti-kindling, i.e. unlearning of abnormally strong synaptic connectivity and abnormal neuronal synchrony. Long-lasting desynchronizing aftereffects of CR stimulation have been verified in pre-clinical and clinical proof of concept studies. In general, for different neuromodulation approaches, both invasive and non-invasive, it is desirable to enable effective stimulation at reduced stimulation intensities, thereby avoiding side effects. For the first time, we here present a two-stage CR stimulation protocol, where two qualitatively different types of CR stimulation are delivered one after another, and the first stage comes at a particularly weak stimulation intensity. Numerical simulations show that a two-stage CR stimulation can induce the same degree of anti-kindling as a single-stage CR stimulation with intermediate stimulation intensity. This stimulation approach might be clinically beneficial in patients suffering from brain diseases characterized by abnormal neuronal synchrony where a first treatment stage should be performed at particularly weak stimulation intensities in order to avoid side effects. This might, e.g., be relevant in the context of acoustic CR stimulation in tinnitus patients with hyperacusis or in the case of electrical deep brain CR stimulation with sub-optimally positioned leads or side effects caused by stimulation of the target itself. We discuss how to apply our method in first in man and proof of concept studies.
Exclusion of NFAT5 from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase.
Anaïs Estrada-Gelonch
signals acting in interphase, resets the cytoplasmic localization of NFAT5 and prevents its nuclear accumulation and association with DNA in the absence of hypertonic stress.
Curve of Spee and Its Relationship with Dentoskeletal Morphology
Prerna Raje Batham
2013-01-01
Conclusion: The curve of Spee is related to various dentoskeletal variables. Thus, the determination of this relationship is useful to assess the feasibility of leveling the curve of Spee by orthodontic treatment.
Approximation by planar elastic curves
Brander, David; Gravesen, Jens; Nørbjerg, Toke Bjerge
2016-01-01
We give an algorithm for approximating a given plane curve segment by a planar elastic curve. The method depends on an analytic representation of the space of elastic curve segments, together with a geometric method for obtaining a good initial guess for the approximating curve. A gradient......-driven optimization is then used to find the approximating elastic curve....
Supersymmetric Spacetimes from Curved Superspace
Kuzenko, Sergei M
2015-01-01
We review the superspace technique to determine supersymmetric spacetimes in the framework of off-shell formulations for supergravity in diverse dimensions using the case of 3D N=2 supergravity theories as an illustrative example. This geometric formalism has several advantages over other approaches advocated in the last four years. Firstly, the infinitesimal isometry transformations of a given curved superspace form, by construction, a finite-dimensional Lie superalgebra, with its odd part corresponding to the rigid supersymmetry transformations. Secondly, the generalised Killing spinor equation, which must be obeyed by the supersymmetry parameters, is a consequence of the more fundamental superfield Killing equation. Thirdly, general rigid supersymmetric theories on a curved spacetime are readily constructed in superspace by making use of the known off-shell supergravity-matter couplings and restricting them to the background chosen. It is the superspace techniques which make it possible to generate arbitra...
Stankova-Frenkel, Z E
1997-01-01
We study the moduli of trigonal curves. We establish the exact upper bound of ${36(g+1)}/(5g+1)$ for the slope of trigonal fibrations. Here, the slope of any fibration $X\\to B$ of stable curves with smooth general member is the ratio Hodge class $\\lambda$ on the moduli space $\\bar{\\mathfrak{M}}_g$ to the base $B$. We associate to a trigonal family $X$ a canonical rank two vector bundle $V$, and show that for Bogomolov-semistable $V$ the slope satisfies the stronger inequality ${\\delta_B}/{\\lambda_B}\\leq 7+{6}/{g}$. We further describe the rational Picard group of the {trigonal} locus $\\bar{\\mathfrak T}_g$ in the moduli space $\\bar{\\mathfrak{M}}_g$ of genus $g$ curves. In the even genus case, we interpret the above Bogomolov semistability condition in terms of the so-called Maroni divisor in $\\bar{\\mathfrak T}_g$.
Gómez Arranz, Paula; Vesth, Allan
This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here, the refere......This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here......, the reference wind speed used in the power curve is the equivalent wind speed obtained from lidar measurements at several heights between lower and upper blade tip, in combination with a hub height meteorological mast. The measurements have been performed using DTU’s measurement equipment, the analysis...
Leslie, Mark; Holloway, Charles A
2006-01-01
When a company launches a new product into a new market, the temptation is to immediately ramp up sales force capacity to gain customers as quickly as possible. But hiring a full sales force too early just causes the firm to burn through cash and fail to meet revenue expectations. Before it can sell an innovative product efficiently, the entire organization needs to learn how customers will acquire and use it, a process the authors call the sales learning curve. The concept of a learning curve is well understood in manufacturing. Employees transfer knowledge and experience back and forth between the production line and purchasing, manufacturing, engineering, planning, and operations. The sales learning curve unfolds similarly through the give-and-take between the company--marketing, sales, product support, and product development--and its customers. As customers adopt the product, the firm modifies both the offering and the processes associated with making and selling it. Progress along the manufacturing curve is measured by tracking cost per unit: The more a firm learns about the manufacturing process, the more efficient it becomes, and the lower the unit cost goes. Progress along the sales learning curve is measured in an analogous way: The more a company learns about the sales process, the more efficient it becomes at selling, and the higher the sales yield. As the sales yield increases, the sales learning process unfolds in three distinct phases--initiation, transition, and execution. Each phase requires a different size--and kind--of sales force and represents a different stage in a company's production, marketing, and sales strategies. Adjusting those strategies as the firm progresses along the sales learning curve allows managers to plan resource allocation more accurately, set appropriate expectations, avoid disastrous cash shortfalls, and reduce both the time and money required to turn a profit.
Three-body choreographies in given curves
Ozaki, Hiroshi [General Education Program Center, Tokai University, 317 Nishino, Numazu, Shizuoka 410-0395 (Japan); Fukuda, Hiroshi; Fujiwara, Toshiaki [College of Liberal Arts and Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555 (Japan)], E-mail: ozaki@keyaki.cc.u-tokai.ac.jp, E-mail: fukuda@kitasato-u.ac.jp, E-mail: fujiwara@kitasato-u.ac.jp
2009-10-02
As shown by Johannes Kepler in 1609, in the two-body problem, the shape of the orbit, a given ellipse, and a given non-vanishing constant angular momentum determine the motion of the planet completely. Even in the three-body problem, in some cases, the shape of the orbit, conservation of the center of mass and a constant of motion (the angular momentum or the total energy) determine the motion of the three bodies. We show, by a geometrical method, that choreographic motions, in which equal mass three bodies chase each other around the same curve, will be uniquely determined for the following two cases. (i) Convex curves that have point symmetry and non-vanishing angular momentum are given. (ii) Eight-shaped curves which are similar to the curve for the figure-eight solution and the energy constant are given. The reality of the motion should be tested whether the motion satisfies an equation of motion or not. Extensions of the method for generic curves are shown. The extended methods are applicable to generic curves which do not have point symmetry. Each body may have its own curve and its own non-vanishing masses.
Algebraic curves and cryptography
Murty, V Kumar
2010-01-01
It is by now a well-known paradigm that public-key cryptosystems can be built using finite Abelian groups and that algebraic geometry provides a supply of such groups through Abelian varieties over finite fields. Of special interest are the Abelian varieties that are Jacobians of algebraic curves. All of the articles in this volume are centered on the theme of point counting and explicit arithmetic on the Jacobians of curves over finite fields. The topics covered include Schoof's \\ell-adic point counting algorithm, the p-adic algorithms of Kedlaya and Denef-Vercauteren, explicit arithmetic on
Gómez Arranz, Paula; Villanueva, Héctor
This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here......, the reference wind speed used in the power curve is the equivalent wind speed obtained from lidar measurements at several heights between lower and upper blade tip, in combination with a hub height meteorological mast. The measurements have been performed using DTU’s measurement equipment, the analysis...
Villanueva, Héctor; Vesth, Allan
are not performed according to IEC 61400-12-1 [1]. Therefore, the results presented in this report cannot be considered a power curve according to the reference standard, and are referred to as “power curve investigation” instead. The measurements have been performed by a customer and the data analysis has been......This report describes the analysis carried out with data from a given turbine in a wind farm and a chosen period. The purpose of the analysis is to correlate the power output of the wind turbine to the wind speed measured by a nacelle-mounted anemometer. The measurements and analysis...
Miriam Raquel Diniz Zanetti
Full Text Available CONTEXT AND OBJECTIVE: Several risk factors are involved in perineal lacerations during vaginal delivery. However, little is known about the influence of perineal distensibility as a protective factor. The aim here was to determine a cutoff value for pelvic floor distensibility measured using the Epi-no balloon, which could be used as a predictive factor for perineal integrity in vaginal delivery. DESIGN AND SETTING: Prospective observational single cohort study conducted in a maternity hospital. METHODS: A convenience sample of 227 consecutive at-term parturients was used. All women had a single fetus in the vertex presentation, with up to 9.0 cm of dilation. The maximum dilation of the Epi-no balloon was measured using a tape measure after it had been inflated inside the vagina up to the parturients' maximum tolerance. The receiver operating characteristic (ROC curve was used to obtain the Epi-no circumference measurement with best sensitivity and specificity. RESULTS: Among the 161 patients who were included in the study, 50.9% underwent episiotomy, 21.8% presented lacerations and 27.3% retained an intact perineum. Age > 25.9 years; number of pregnancies > 3.4; number of deliveries > 2.2 and circumference measured by Epi-no > 21.4 cm were all directly correlated with an intact perineum. Circumference measurements using the Epi-no balloon that were greater than 20.8 cm showed sensitivity and specificity of 70.5% and 66.7% (area under curve = 0.713, respectively, as a predictive factor for an intact perineum in vaginal delivery. CONCLUSION: Circumferences greater than 20.8 cm achieved using the Epi-no balloon are a predictive factor for perineal integrity in parturients.
Paths of algebraic hyperbolic curves
Ya-juan LI; Li-zheng LU; Guo-zhao WANG
2008-01-01
Cubic algebraic hyperbolic (AH) Bezier curves and AH spline curves are defined with a positive parameter α in the space spanned by {1, t, sinht, cosht}. Modifying the value of α yields a family of AH Bezier or spline curves with the family parameter α. For a fixed point on the original curve, it will move on a defined curve called "path of AH curve" (AH Bezier and AH spline curves) when α changes. We describe the geometric effects of the paths and give a method to specify a curve passing through a given point.
de Oliveira, Rodrigo Rocha; de Lima, Kássio Michell Gomes; Tauler, Romà; de Juan, Anna
2014-07-01
This study describes two applications of a variant of the multivariate curve resolution alternating least squares (MCR-ALS) method with a correlation constraint. The first application describes the use of MCR-ALS for the determination of biodiesel concentrations in biodiesel blends using near infrared (NIR) spectroscopic data. In the second application, the proposed method allowed the determination of the synthetic antioxidant N,N'-Di-sec-butyl-p-phenylenediamine (PDA) present in biodiesel mixtures from different vegetable sources using UV-visible spectroscopy. Well established multivariate regression algorithm, partial least squares (PLS), were calculated for comparison of the quantification performance in the models developed in both applications. The correlation constraint has been adapted to handle the presence of batch-to-batch matrix effects due to ageing effects, which might occur when different groups of samples were used to build a calibration model in the first application. Different data set configurations and diverse modes of application of the correlation constraint are explored and guidelines are given to cope with different type of analytical problems, such as the correction of matrix effects among biodiesel samples, where MCR-ALS outperformed PLS reducing the relative error of prediction RE (%) from 9.82% to 4.85% in the first application, or the determination of minor compound with overlapped weak spectroscopic signals, where MCR-ALS gave higher (RE (%)=3.16%) for prediction of PDA compared to PLS (RE (%)=1.99%), but with the advantage of recovering the related pure spectral profile of analytes and interferences. The obtained results show the potential of the MCR-ALS method with correlation constraint to be adapted to diverse data set configurations and analytical problems related to the determination of biodiesel mixtures and added compounds therein. Copyright © 2014 Elsevier B.V. All rights reserved.
Fires: Pushing the Reset Button or a Flash in the Pan?
MacDonald, L. H.; Wagenbrenner, J. W.; Robichaud, P. R.; Nelson, P. A.; Kampf, S. K.; Brogan, D. J.
2016-12-01
High and moderate severity wildfires can reduce infiltration rates to less than 10 mm/hr, and the resulting surface runoff can increase small-scale peak flows by one or more orders of magnitude. Fires can increase hillslope erosion rates by several orders of magnitude, but this increase is less linear with rainfall intensity because it also depends on sediment supply and detachment processes as well as transport capacity. These localized and shorter-term effects have been relatively well documented, but there is much more uncertainty in how these fire-induced changes can lead to larger-scale and/or longer-term effects. The goal of this presentation is to provide a process-based analysis of how, where, and when wildfires can cause either longer-term or larger-scale changes, effectively resetting the system as opposed to a more transient "flash in the pan". An understanding of vegetation, climatic, and geomorphic dynamics are are critical for predicting larger-scale and longer-term effects. First is the potential for the vegetation to return to pre-fire conditions, and this depends on vegetation type, spatial extent of the fire, and if the pre-fire vegetation is marginalized by climate change, land use, or other factors. The trajectory of post-fire regrowth controls the duration of increased runoff and erosion as well as the size and severity of future fires, which then sets the scene for longer-term hydrologic and geomorphic change. Climate defines the dominant storm type and how they match up with the spatial extent of a fire. Historic data help estimate the extent and magnitude of post-fire rainfall, but there is a strong stochastic component and the more extreme events are of greatest concern. Geomorphic controls on larger-scale effects include the valley and drainage network characteristics that help govern the storage and delivery of water and sediment. Assessing each component involves multiple site factors, but the biggest problem is understanding their
Gómez Arranz, Paula; Wagner, Rozenn
This report describes the power curve measurements performed with a nacelle LIDAR on a given wind turbine in a wind farm and during a chosen measurement period. The measurements and analysis are carried out in accordance to the guidelines in the procedure “DTU Wind Energy-E-0019” [1]. The reporting...
Kool, J.
2013-01-01
This thesis has three main subjects. The first subject is Measure-theoretic rigidity of Mumford Curves. One can describe isomorphism of two compact hyperbolic Riemann surfaces of the same genus by a measure-theoretic property: a chosen isomorphism of their fundamental groups corresponds to a homeomo
Vesth, Allan; Kock, Carsten Weber
The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present anal...
Villanueva, Héctor; Gómez Arranz, Paula
The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...
Gómez Arranz, Paula; Villanueva, Héctor
The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...
Ph.H.B.F. Franses (Philip Hans)
1994-01-01
textabstractIn this paper, a simple Gompertz curve-fitting procedure is proposed. Its advantages include the facts that the stability of the saturation level over the sample period can be checked, and that no knowledge of its value is necessary for forecasting. An application to forecasting the stoc
Gompertz curves with seasonality
Ph.H.B.F. Franses (Philip Hans)
1994-01-01
textabstractThis paper considers an extension of the usual Gompertz curve by allowing the parameters to vary over the seasons. This means that, for example, saturation levels can be different over the year. An estimation and testing method is proposed and illustrated with an example.
Gómez Arranz, Paula; Vesth, Allan
The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...
Vesth, Allan; Yordanova, Ginka
The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...
Lawes, Jonathan F.
2013-01-01
Graphing polar curves typically involves a combination of three traditional techniques, all of which can be time-consuming and tedious. However, an alternative method--graphing the polar function on a rectangular plane--simplifies graphing, increases student understanding of the polar coordinate system, and reinforces graphing techniques learned…
Power Curve Measurements, REWS
Villanueva, Héctor; Gómez Arranz, Paula
This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here, the refere...
Federici, Paolo; Kock, Carsten Weber
This report describes the power curve measurements performed with a nacelle LIDAR on a given wind turbine in a wind farm and during a chosen measurement period. The measurements and analysis are carried out in accordance to the guidelines in the procedure “DTU Wind Energy-E-0019” [1]. The reporting...
Straightening Out Learning Curves
Corlett, E. N.; Morecombe, V. J.
1970-01-01
The basic mathematical theory behind learning curves is explained, together with implications for clerical and industrial training, evaluation of skill development, and prediction of future performance. Brief studies of textile worker and typist training are presented to illustrate such concepts as the reduction fraction (a consistent decrease in…
Groot, L.F.M.
The purpose of this paper is twofold. First, it exhibits that standard tools in the measurement of income inequality, such as the Lorenz curve and the Gini-index, can successfully be applied to the issues of inequality measurement of carbon emissions and the equity of abatement policies across
Kock, Carsten Weber; Federici, Paolo
The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...... analyze of power performance of the turbine....
Kock, Carsten Weber; Vesth, Allan
The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...... analyze of power performance of the turbine....
Ferrari, Eduardo Luiz; Jardini, Jose Antonio
1996-07-01
This work presents some applications of the residential loads, obtained from measurements conducted by the electric power utilities in the state of Sao Paulo , Brazil. During the first application, curve of coincidence of load peaks occurrence, as function of the number of consumers simultaneously connected to a specific residential distribution transformer. This curve provides a information on the number of consumers presenting coincident load peaks coincident relative to the total numbers of consumers connected to the distribution transformer. Those curves allow to obtain the diversity curves. The second application focused the calculation of the distribution transformer life reduction.
Pan, Chih-Hung; Chang, Ting-Chang; Tsai, Tsung-Ming; Chang, Kuan-Chang; Chu, Tian-Jian; Lin, Wen-Yan; Chen, Min-Chen; Sze, Simon M.
2016-09-01
In this letter, we demonstrate completely different characteristics with different operating modes and analyze the electrical field effect to confirm the filament dissolution behavior. The device exhibited a larger memory window when using a single voltage sweep method during reset process rather than the traditional double sweep method. The phenomenon was verified by using fast I-V measurement to simulate the two operating methods. A better high resistance state (HRS) will be obtained with a very short rising time pulse, but quite notably, lower power consumption was needed. We proposed the electrical field effect to explain the phenomenon and demonstrate distribution by COMSOL simulation.
Groot, L. [Utrecht University, Utrecht School of Economics, Janskerkhof 12, 3512 BL Utrecht (Netherlands)
2008-11-15
The purpose of this paper is twofold. First, it exhibits that standard tools in the measurement of income inequality, such as the Lorenz curve and the Gini-index, can successfully be applied to the issues of inequality measurement of carbon emissions and the equity of abatement policies across countries. These tools allow policy-makers and the general public to grasp at a single glance the impact of conventional distribution rules such as equal caps or grandfathering, or more sophisticated ones, on the distribution of greenhouse gas emissions. Second, using the Samuelson rule for the optimal provision of a public good, the Pareto-optimal distribution of carbon emissions is compared with the distribution that follows if countries follow Nash-Cournot abatement strategies. It is shown that the Pareto-optimal distribution under the Samuelson rule can be approximated by the equal cap division, represented by the diagonal in the Lorenz curve diagram.
Iram Ansari
2012-01-01
Full Text Available Dilaceration is the result of a developmental anomaly in which there has been an abrupt change in the axial inclination between the crown and the root of a tooth. Dilaceration can be seen in both the permanent and deciduous dentitions, and is more commonly found in posterior teeth and in maxilla. Periapical radiographs are the most appropriate way to diagnose the presence of root dilacerations. The controlled regularly tapered preparation of the curved canals is the ultimate challenge in endodontics. Careful and meticulous technique will yield a safe and sufficient enlargement of the curved canals. This article gives a review of the literature and three interesting case reports of root dilacerations.
Vo, Martin
2017-08-01
Light Curves Classifier uses data mining and machine learning to obtain and classify desired objects. This task can be accomplished by attributes of light curves or any time series, including shapes, histograms, or variograms, or by other available information about the inspected objects, such as color indices, temperatures, and abundances. After specifying features which describe the objects to be searched, the software trains on a given training sample, and can then be used for unsupervised clustering for visualizing the natural separation of the sample. The package can be also used for automatic tuning parameters of used methods (for example, number of hidden neurons or binning ratio). Trained classifiers can be used for filtering outputs from astronomical databases or data stored locally. The Light Curve Classifier can also be used for simple downloading of light curves and all available information of queried stars. It natively can connect to OgleII, OgleIII, ASAS, CoRoT, Kepler, Catalina and MACHO, and new connectors or descriptors can be implemented. In addition to direct usage of the package and command line UI, the program can be used through a web interface. Users can create jobs for ”training” methods on given objects, querying databases and filtering outputs by trained filters. Preimplemented descriptors, classifier and connectors can be picked by simple clicks and their parameters can be tuned by giving ranges of these values. All combinations are then calculated and the best one is used for creating the filter. Natural separation of the data can be visualized by unsupervised clustering.
Pelce, Pierre
1989-01-01
In recent years, much progress has been made in the understanding of interface dynamics of various systems: hydrodynamics, crystal growth, chemical reactions, and combustion. Dynamics of Curved Fronts is an important contribution to this field and will be an indispensable reference work for researchers and graduate students in physics, applied mathematics, and chemical engineering. The book consist of a 100 page introduction by the editor and 33 seminal articles from various disciplines.
Estimating Corporate Yield Curves
Antionio Diaz; Frank Skinner
2001-01-01
This paper represents the first study of retail deposit spreads of UK financial institutions using stochastic interest rate modelling and the market comparable approach. By replicating quoted fixed deposit rates using the Black Derman and Toy (1990) stochastic interest rate model, we find that the spread between fixed and variable rates of interest can be modeled (and priced) using an interest rate swap analogy. We also find that we can estimate an individual bank deposit yield curve as a spr...
Steenwyk, Steven D; Molnar, Lawrence A
2013-01-01
We have identified some two-hundred new variable stars in a systematic study of a data archive obtained with the Calvin-Rehoboth observatory. Of these, we present five close binaries showing behaviors presumably due to star spots or other magnetic activity. For context, we first present two new RS CVn systems whose behavior can be readily attribute to star spots. Then we present three new close binary systems that are rather atypical, with light curves that are changing over time in ways not easily understood in terms of star spot activity generally associated with magnetically active binary systems called RS CVn systems. Two of these three are contact binaries that exhibit gradual changes in average brightness without noticeable changes in light curve shape. A third system has shown such large changes in light curve morphology that we speculate this may be a rare instance of a system that transitions back and forth between contact and noncontact configurations, perhaps driven by magnetic cycles in at least o...
李立新; 胡盛德; 叶奔
2012-01-01
To determine the twinning kinetics and the influence of twins on dislocation density and flow stress of 304 stainless steel, a constitutive relation model including the twinning kinetics was established by using dislocation theory and the stress-strain curve measured. The undetermined coefficients in this model were optimized by the tensile test data. Therefore, the model of twinning kinetics was obtained. Results for the model show that the dislocation density and flow stress increase rapidly with the increase of deformation when twins exist.%为确定304不锈钢的孪生动力学模型及孪生对位错密度和变形抗力的影响规律,利用位错理论建立了含材料孪生动力学关系的本构关系模型,实测了材料的应力应变曲线,运用实测结果优化确定了本构关系模型中的待定常数,进而建立了材料的孪生动力学关系模型,本构关系模型还表明,在孪生条件下,材料的位错密度及变形抗力随变形程度增加而快速增大.
Mendes, Bruno M.; Freitas, Marcelo H.A. de; Campos, Tarcisio P.R. [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear; Silva, Luciana M.; Dias, Consuelo L.F. [Fundacao Ezequiel Dias, Belo Horizonte, MG (Brazil). Dept. de Pesquisa. Lab. de Bioquimica
2000-07-01
The effect of the radiation in tissue and cells are a theme of extreme importance and that is receiving large attention more and more now. This work purposes to evaluate the deleterious effects of the neutrons radiation at low dose rate in lineages of human cancerous cells through the analysis of survival curves. Deleterious effects due to radiation of low dose rate (3.8 mSv/hr) were observed in cells of the lineage HeLa S3. Previous studies, in lineage HN5 of tongue carcinoma, showed survive level to 0.2Sv of 80%, compatible to the value of 88,57% 0.4 Sv obtained for HeLa S3. In a close future, with the molecular biology characterization of a great number or possibly all cancer types (that will be accelerated largely with the conclusion of the human genome project), studies like this, can be much more specific, and could determine the efficiency of the neutrons or any other radiation type for each one of those types. Those data would have of great value for the medicine and they would help to plan the treatments better. (author)
单片机复位问题的分析与研究%Analysis and Research on the Reset Problem of SCM TMP89FS60 Toshiba
陈妃味; 洪忠玮
2014-01-01
In the application system design of SCM, the reset process is basis and critical. This paper expounds the reset and anti-interference problems in the SCM TMP89FS60 Toshiba. Then it mainly analyzes that how to guarantee the operational reliability of SCM system. Last it introduces several kinds of relative system reset.%在单片机应用系统设计中，复位处理是一个最基本又极为关键的问题。本文以东芝单片机TMP89FS60为例，较全面地阐述了单片机的复位和抗干扰问题，并就如何保证单片机系统运行可靠性进行了分析，介绍了几种相关的系统复位。
Evaluation of the Phase-Dependent Rhythm Control of Human Walking Using Phase Response Curves.
Tetsuro Funato
2016-05-01
Full Text Available Humans and animals control their walking rhythms to maintain motion in a variable environment. The neural mechanism for controlling rhythm has been investigated in many studies using mechanical and electrical stimulation. However, quantitative evaluation of rhythm variation in response to perturbation at various timings has rarely been investigated. Such a characteristic of rhythm is described by the phase response curve (PRC. Dynamical simulations of human skeletal models with changing walking rhythms (phase reset described a relation between the effective phase reset on stability and PRC, and phase reset around touch-down was shown to improve stability. A PRC of human walking was estimated by pulling the swing leg, but such perturbations hardly influenced the stance leg, so the relation between the PRC and walking events was difficult to discuss. This research thus examines human response to variations in floor velocity. Such perturbation yields another problem, in that the swing leg is indirectly (and weakly perturbed, so the precision of PRC decreases. To solve this problem, this research adopts the weighted spike-triggered average (WSTA method. In the WSTA method, a sequential pulsed perturbation is used for stimulation. This is in contrast with the conventional impulse method, which applies an intermittent impulsive perturbation. The WSTA method can be used to analyze responses to a large number of perturbations for each sequence. In the experiment, perturbations are applied to walking subjects by rapidly accelerating and decelerating a treadmill belt, and measured data are analyzed by the WSTA and impulse methods. The PRC obtained by the WSTA method had clear and stable waveforms with a higher temporal resolution than those obtained by the impulse method. By investigation of the rhythm transition for each phase of walking using the obtained PRC, a rhythm change that extends the touch-down and mid-single support phases is found to occur.
Evaluation of the Phase-Dependent Rhythm Control of Human Walking Using Phase Response Curves.
Funato, Tetsuro; Yamamoto, Yuki; Aoi, Shinya; Imai, Takashi; Aoyagi, Toshio; Tomita, Nozomi; Tsuchiya, Kazuo
2016-05-01
Humans and animals control their walking rhythms to maintain motion in a variable environment. The neural mechanism for controlling rhythm has been investigated in many studies using mechanical and electrical stimulation. However, quantitative evaluation of rhythm variation in response to perturbation at various timings has rarely been investigated. Such a characteristic of rhythm is described by the phase response curve (PRC). Dynamical simulations of human skeletal models with changing walking rhythms (phase reset) described a relation between the effective phase reset on stability and PRC, and phase reset around touch-down was shown to improve stability. A PRC of human walking was estimated by pulling the swing leg, but such perturbations hardly influenced the stance leg, so the relation between the PRC and walking events was difficult to discuss. This research thus examines human response to variations in floor velocity. Such perturbation yields another problem, in that the swing leg is indirectly (and weakly) perturbed, so the precision of PRC decreases. To solve this problem, this research adopts the weighted spike-triggered average (WSTA) method. In the WSTA method, a sequential pulsed perturbation is used for stimulation. This is in contrast with the conventional impulse method, which applies an intermittent impulsive perturbation. The WSTA method can be used to analyze responses to a large number of perturbations for each sequence. In the experiment, perturbations are applied to walking subjects by rapidly accelerating and decelerating a treadmill belt, and measured data are analyzed by the WSTA and impulse methods. The PRC obtained by the WSTA method had clear and stable waveforms with a higher temporal resolution than those obtained by the impulse method. By investigation of the rhythm transition for each phase of walking using the obtained PRC, a rhythm change that extends the touch-down and mid-single support phases is found to occur.
Structural origin of set-reset process in a new bulk Si15Te83Ge2 phase-change memory material
Srinivasa Rao Gunti
2011-03-01
Full Text Available A new phase-change memory material, in bulk, has been prepared by melt-quenching technique, which has a better glass forming ability. This sample is set and resettable relatively easily for several cycles at 2mA SET and RESET input currents, and is likely to be a suitable material for phase-change memory applications. Raman scattering studies have been undertaken during the SET and RESET operations to elucidate the local structural transformations that occur during these operations.
Curved PVDF airborne transducer.
Wang, H; Toda, M
1999-01-01
In the application of airborne ultrasonic ranging measurement, a partially cylindrical (curved) PVDF transducer can effectively couple ultrasound into the air and generate strong sound pressure. Because of its geometrical features, the ultrasound beam angles of a curved PVDF transducer can be unsymmetrical (i.e., broad horizontally and narrow vertically). This feature is desired in some applications. In this work, a curved PVDF air transducer is investigated both theoretically and experimentally. Two resonances were observed in this transducer. They are length extensional mode and flexural bending mode. Surface vibration profiles of these two modes were measured by a laser vibrometer. It was found from the experiment that the surface vibration was not uniform along the curvature direction for both vibration modes. Theoretical calculations based on a model developed in this work confirmed the experimental results. Two displacement peaks were found in the piezoelectric active direction of PVDF film for the length extensional mode; three peaks were found for the flexural bending mode. The observed peak positions were in good agreement with the calculation results. Transient surface displacement measurements revealed that vibration peaks were in phase for the length extensional mode and out of phase for the flexural bending mode. Therefore, the length extensional mode can generate a stronger ultrasound wave than the flexural bending mode. The resonance frequencies and vibration amplitudes of the two modes strongly depend on the structure parameters as well as the material properties. For the transducer design, the theoretical model developed in this work can be used to optimize the ultrasound performance.
Magnetism in curved geometries
Streubel, Robert; Fischer, Peter; Kronast, Florian; Kravchuk, Volodymyr P.; Sheka, Denis D.; Gaididei, Yuri; Schmidt, Oliver G.; Makarov, Denys
2016-09-01
Extending planar two-dimensional structures into the three-dimensional space has become a general trend in multiple disciplines, including electronics, photonics, plasmonics and magnetics. This approach provides means to modify conventional or to launch novel functionalities by tailoring the geometry of an object, e.g. its local curvature. In a generic electronic system, curvature results in the appearance of scalar and vector geometric potentials inducing anisotropic and chiral effects. In the specific case of magnetism, even in the simplest case of a curved anisotropic Heisenberg magnet, the curvilinear geometry manifests two exchange-driven interactions, namely effective anisotropy and antisymmetric exchange, i.e. Dzyaloshinskii-Moriya-like interaction. As a consequence, a family of novel curvature-driven effects emerges, which includes magnetochiral effects and topologically induced magnetization patterning, resulting in theoretically predicted unlimited domain wall velocities, chirality symmetry breaking and Cherenkov-like effects for magnons. The broad range of altered physical properties makes these curved architectures appealing in view of fundamental research on e.g. skyrmionic systems, magnonic crystals or exotic spin configurations. In addition to these rich physics, the application potential of three-dimensionally shaped objects is currently being explored as magnetic field sensorics for magnetofluidic applications, spin-wave filters, advanced magneto-encephalography devices for diagnosis of epilepsy or for energy-efficient racetrack memory devices. These recent developments ranging from theoretical predictions over fabrication of three-dimensionally curved magnetic thin films, hollow cylinders or wires, to their characterization using integral means as well as the development of advanced tomography approaches are in the focus of this review.
Quaternion orders, quadratic forms, and Shimura curves
Alsina, Montserrat
2004-01-01
Shimura curves are a far-reaching generalization of the classical modular curves. They lie at the crossroads of many areas, including complex analysis, hyperbolic geometry, algebraic geometry, algebra, and arithmetic. The text provides an introduction to the subject from a theoretic and algorithmic perspective. The main topics covered in it are Shimura curves defined over the rational number field, the construction of their fundamental domains, and the determination of their complex multiplication points. The study of complex multiplication points in Shimura curves leads to the study of families of binary quadratic forms with algebraic coefficients and to their classification by arithmetic Fuchsian groups. In this regard, the authors develop a theory full of new possibilities which parallels Gauss' theory on the classification of binary quadratic forms with integral coefficients by the action of the modular group. Each topic covered in the book begins with a theoretical discussion followed by carefully worked...
王胜峰; 邹永华; 周彦彬; 田娟; 左英; 冉黎灵; 丁劲松
2011-01-01
目的 建立人血浆中辅酶Q10的HPLC-UV测定法,考察正常人内源性辅酶Q10的经时变化过程,并研究辅酶Q10胶囊连续给药后血浆中辅酶Q10变化规律.方法 无辅酶Q10血浆经低温光照后获得,作为方法学建立的空白背景.血浆样品经正己烷-乙醇=9:1提取后,由迪马Diamonsil C18柱(4.6 mm ×200 mm,5μm)分离,流动相为甲醇·乙醇(10:90),维生素K1为内标,检测波长为275 nm.18名志愿者在控制饮食2 d后,不同时间点采血并测定血浆中内源性辅酶Q10的变化规律,随后连续给予辅酶Q10胶囊同时间点采血,考察血浆中辅酶Q10浓度的升高情况.结果 血浆中杂质不干扰样品峰,线性范围为0.156～10.0μg·mL-1(r=0.999 9),定量下限为0.156μg·mL-1.受试者经控制饮食2 d后血浆中内源性辅酶Q10浓度达到稳定状态,连续给予辅酶Q10胶囊后血浆中辅酶Q10的浓度增加明显.结论 新建立的人血浆中辅酶Q10测定法,简单快速,准确度高,空白基质选择合理,处理恰当.连续给药的方法可用于评价辅酶Q10的生物利用度.%OBJECTIVE To develop and validate a simple HPLC-UV method for the determination of coenzyme Q10 and to investigate the concentration-time curve of coenzyme Q10 in human plasma before and after multiple doses administration.METHODS Coenzyme Q10 inblank plasma was decomposed by light and the plasma was applied as the blank background correction.Coenzyme Q10 inplasma was extracted with n-hexane-ethanol (9∶1 ), and then the separation was performed on a Diamonsil C18 column (4.6 mm ×200 mm, 5 μm) with a mixture of methanol-ethanol (10∶90 v/v) as mobile phase.The internal standard was vitamin K1.The detection wavelength was 275 nm.The concentration-time curve of endogenous coenzyme Q10 was determined in 18 volunteers with the controlled diet for 2 d.The incremental coenzyme Q10 was determined after multiple doses of coenzyme Q10capsules.RESULTS Coenzyme Q10was separated from the
Three-Body Choreographies in Given Curves
Ozaki, Hiroshi; Fujiwara, Toshiaki
2009-01-01
As shown by Johannes Kepler in 1609, in the two-body problem, the shape of the orbit, a given ellipse, and a given non-vanishing constant angular momentum determines the motion of the planet completely. Even in the three-body problem, in some cases, the shape of the orbit, conservation of the centre of mass and a constant of motion (the angular momentum or the total energy) determines the motion of the three bodies. We show, by a geometrical method, that choreographic motions, in which equal mass three bodies chase each other around a same curve, will be uniquely determined for the following two cases. (i) Convex curves that have point symmetry and non-vanishing angular momentum are given. (ii) Eight-shaped curves which are similar to the curve for the figure-eight solution and the energy constant are given. The reality of the motion should be tested whether the motion satisfies an equation of motion or not. Extensions of the method for generic curves are shown. The extended methods are applicable to generic ...
Superfluids in Curved Spacetime
Villegas, Kristian Hauser A
2015-01-01
Superfluids under an intense gravitational field are typically found in neutron star and quark star cores. Most treatments of these superfluids, however, are done in a flat spacetime background. In this paper, the effect of spacetime curvature on superfluidity is investigated. An effective four-fermion interaction is derived by integrating out the mediating scalar field. The fermions interacting via the mediating gauge vector bosons is also discussed. Two possible cases are considered in the mean-field treatment: antifermion-fermion and fermion-fermion pairings. An effective action, quadratic in fermion field, and a self-consistent equation are derived for both cases. The effective Euclidean action and the matrix elements of the heat kernel operator, which are very useful in curved-spacetime QFT calculations, are derived for the fermion-fermion pairing. Finally, explicit numerical calculation of the gravitational correction to the pairing order parameter is performed for the scalar superfluid case. It is foun...
Yaman, K; Solis, F J; Witten, T A
1996-01-01
We apply results derived in other contexts for the spectrum of the Laplace operator in curved geometries to the study of an ideal polymer chain confined to a spherical annulus in arbitrary space dimension D and conclude that the free energy compared to its value for an uncurved box of the same thickness and volume, is lower when $D < 3$, stays the same when $D = 3$, and is higher when lowers the effective bending elasticity of the walls, and might induce spontaneous symmetry breaking, i.e. bending. (Actually, the above mentioned results show that {\\em {any}} shell in $D = 3$ induces this effect, except for a spherical shell). We compute the contribution of this effect to the bending rigidities in the Helfrich free energy expression.
Evolutes of Hyperbolic Plane Curves
Shyuichi IZUMIYA; Dong He PEI; Takashi SANO; Erika TORII
2004-01-01
We define the notion of evolutes of curves in a hyperbolic plane and establish the relationships between singularities of these subjects and geometric invariants of curves under the action of the Lorentz group. We also describe how we can draw the picture of an evolute of a hyperbolic plane curve in the Poincar(e) disk.
The Arithmetic of Elliptic Curves
Silverman, Joseph H
2009-01-01
Treats the arithmetic theory of elliptic curves in its modern formulation, through the use of basic algebraic number theory and algebraic geometry. This book discusses the necessary algebro-geometric results, and offers an exposition of the geometry of elliptic curves, and the formal group of an elliptic curve.
Je Hyun Baekt
2000-01-01
Full Text Available A numerical study is conducted on the fully-developed laminar flow of an incompressible viscous fluid in a square duct rotating about a perpendicular axis to the axial direction of the duct. At the straight duct, the rotation produces vortices due to the Coriolis force. Generally two vortex cells are formed and the axial velocity distribution is distorted by the effect of this Coriolis force. When a convective force is weak, two counter-rotating vortices are shown with a quasi-parabolic axial velocity profile for weak rotation rates. As the rotation rate increases, the axial velocity on the vertical centreline of the duct begins to flatten and the location of vorticity center is moved near to wall by the effect of the Coriolis force. When the convective inertia force is strong, a double-vortex secondary flow appears in the transverse planes of the duct for weak rotation rates but as the speed of rotation increases the secondary flow is shown to split into an asymmetric configuration of four counter-rotating vortices. If the rotation rates are increased further, the secondary flow restabilizes to a slightly asymmetric double-vortex configuration. Also, a numerical study is conducted on the laminar flow of an incompressible viscous fluid in a 90°-bend square duct that rotates about axis parallel to the axial direction of the inlet. At a 90°-bend square duct, the feature of flow by the effect of a Coriolis force and a centrifugal force, namely a secondary flow by the centrifugal force in the curved region and the Coriolis force in the downstream region, is shown since the centrifugal force in curved region and the Coriolis force in downstream region are dominant respectively.
M.M. Rahman
2011-01-01
Full Text Available Ge17Te83-xTlx (x = 2, 3, 6, 8, 10 glasses have been prepared by melt quenching method and their amorphous nature was confirmed by XRD spectra. I-V characteristics and repeatability of electrical switching were investigated for all the glasses in order to find out their suitability for phase change memory applications. A comparison has been given with Ge2Sb2Te5 the most commonly used material for phase change memory application. The entire series of glasses exhibited memory type of electrical switching but only the composition Ge17Te81Tl2 was able to withstand SET-RESET pulses for more than 10 cycles. The other samples show repeatability for only a few cycles with the degradation of threshold voltage.
栗冬梅; 苗志刚; 宋秀平; 王君; 刘起勇
2012-01-01
[目的]应用一种昆虫细胞培养基作为基础成分培养巴尔通体(Bartonella species),建立一种操作方便、高效稳定的巴尔通体液体培养方法.[方法]昆虫细胞培养基中添加10％胎牛血清,以此为基础培养液分别添加蔗糖和谷氨酰胺,比较这两种成分对汉赛巴尔通体(B.henselae)和五日热巴尔通体(B.quintana)生长的影响并观察其他10种巴尔通体在简化后的培养液中的生长特性.[结果]添加蔗糖和谷氨酰胺不会明显促进巴尔通体的生长,10种巴尔通体在简化后的培养液中均生长良好.不同种巴尔通体生长曲线不同,汉赛巴尔通体和五日热巴尔通体的世代时间分别为5.2 h和4.3 h,生长速度快于固体培养.[结论]以昆虫细胞培养基作为基础成分的培养液适于巴尔通体液体培养,特别是对一些更难培养的巴尔通体提供了一种较好的培养方法.%[Objective] We tested an insect cells-based liquid medium and its utility for the easy-to-maintain, fast and reliable system for cultivation of different Bartonella.[Methods] Media composition and growth conditions were optimized using B.henselae and B.quintana.The growth curves of the other ten Bartonella species were determined using the optimized liquid medium.[Results] Glutamine and sucrose supplements did not affect significantly the growth rate of these bacteria.A generation time of 5.2 h for B.henselae and 4.3 h for B.quintana was estimated during the exponential phase of the growth curve occurred between days 1 and 2 after inoculation.The twelve medical and veterinary important Bartonella species grew well under conditions established and each exhibited unique growth characteristics.[Conclusion] This liquid growth medium may provide an advantage over conventional direct blood agar plating for analyzing Bartonella properties including antibiotic susceptibility and resistance and pathogeniciry.
Seluzicki, Adam; Flourakis, Matthieu; Kula-Eversole, Elzbieta; Zhang, Luoying; Kilman, Valerie; Allada, Ravi
2014-03-01
Molecular circadian clocks are interconnected via neural networks. In Drosophila, PIGMENT-DISPERSING FACTOR (PDF) acts as a master network regulator with dual functions in synchronizing molecular oscillations between disparate PDF(+) and PDF(-) circadian pacemaker neurons and controlling pacemaker neuron output. Yet the mechanisms by which PDF functions are not clear. We demonstrate that genetic inhibition of protein kinase A (PKA) in PDF(-) clock neurons can phenocopy PDF mutants while activated PKA can partially rescue PDF receptor mutants. PKA subunit transcripts are also under clock control in non-PDF DN1p neurons. To address the core clock target of PDF, we rescued per in PDF neurons of arrhythmic per⁰¹ mutants. PDF neuron rescue induced high amplitude rhythms in the clock component TIMELESS (TIM) in per-less DN1p neurons. Complete loss of PDF or PKA inhibition also results in reduced TIM levels in non-PDF neurons of per⁰¹ flies. To address how PDF impacts pacemaker neuron output, we focally applied PDF to DN1p neurons and found that it acutely depolarizes and increases firing rates of DN1p neurons. Surprisingly, these effects are reduced in the presence of an adenylate cyclase inhibitor, yet persist in the presence of PKA inhibition. We have provided evidence for a signaling mechanism (PKA) and a molecular target (TIM) by which PDF resets and synchronizes clocks and demonstrates an acute direct excitatory effect of PDF on target neurons to control neuronal output. The identification of TIM as a target of PDF signaling suggests it is a multimodal integrator of cell autonomous clock, environmental light, and neural network signaling. Moreover, these data reveal a bifurcation of PKA-dependent clock effects and PKA-independent output effects. Taken together, our results provide a molecular and cellular basis for the dual functions of PDF in clock resetting and pacemaker output.
Adam Seluzicki
2014-03-01
Full Text Available Molecular circadian clocks are interconnected via neural networks. In Drosophila, PIGMENT-DISPERSING FACTOR (PDF acts as a master network regulator with dual functions in synchronizing molecular oscillations between disparate PDF(+ and PDF(- circadian pacemaker neurons and controlling pacemaker neuron output. Yet the mechanisms by which PDF functions are not clear. We demonstrate that genetic inhibition of protein kinase A (PKA in PDF(- clock neurons can phenocopy PDF mutants while activated PKA can partially rescue PDF receptor mutants. PKA subunit transcripts are also under clock control in non-PDF DN1p neurons. To address the core clock target of PDF, we rescued per in PDF neurons of arrhythmic per⁰¹ mutants. PDF neuron rescue induced high amplitude rhythms in the clock component TIMELESS (TIM in per-less DN1p neurons. Complete loss of PDF or PKA inhibition also results in reduced TIM levels in non-PDF neurons of per⁰¹ flies. To address how PDF impacts pacemaker neuron output, we focally applied PDF to DN1p neurons and found that it acutely depolarizes and increases firing rates of DN1p neurons. Surprisingly, these effects are reduced in the presence of an adenylate cyclase inhibitor, yet persist in the presence of PKA inhibition. We have provided evidence for a signaling mechanism (PKA and a molecular target (TIM by which PDF resets and synchronizes clocks and demonstrates an acute direct excitatory effect of PDF on target neurons to control neuronal output. The identification of TIM as a target of PDF signaling suggests it is a multimodal integrator of cell autonomous clock, environmental light, and neural network signaling. Moreover, these data reveal a bifurcation of PKA-dependent clock effects and PKA-independent output effects. Taken together, our results provide a molecular and cellular basis for the dual functions of PDF in clock resetting and pacemaker output.
A Radiosity Solution for Curved Surface Environments
孙济洲; RichardL.Grimsdale
1997-01-01
Radiosity has been a popular method for photorealistic image generation.But the determination of form factors between curved patches is the most difficult and time consuming procedure,and also the errors caused by approximating source patch's radiosity with average values are obvious.In this paper,a radiosity algorithm for rendering curved surfaces represented by parameters is described.The contributed radiosity from differential areas on four vertices of the source patch to a receiving point is calculated firstly,then the contribution from the inner area of the source patch is evaluated by interpolating the values on four corners.Both the difficult problem of determining form-factors between curved surfaces and errors mentioned above have been avoided.Comparison of the experimental results using the new algorithm has been made with the ones obtained by traditional method.Some associated techniques such as the visibility test and the adaptive subdivision are also described.
Cheng, Ruey-Kuang; Meck, Warren H.; Williams, Christina L.
2006-01-01
We previously showed that prenatal choline supplementation could increase the precision of timing and temporal memory and facilitate simultaneous temporal processing in mature and aged rats. In the present study, we investigated the ability of adult rats to selectively control the reinforcement-induced resetting of an internal clock as a function…
Correlation of pool boiling curves for the homogeous group freons
Westwater, J.W. (Dept. of Chemical Engineering, Univ. of Illnois, Urban, IL (US)); Zinn, J.C. (Monsanto, Co., St. Louis, MO (US)); Brodbeck, K.J. (Clorox Corp., Pleasanton, CA (US))
1989-02-01
A knowledge of the complete boiling curve q verses {Delta}T for a liquid, including the regimes of nucleate boiling, transition boiling, and a film boiling is needed for the design and operation of various types of heat transfer equipment. No general method exists for predicting the complete curve. Most difficult is the prediction of the nucleate boiling curve, the transition curve, and the temperature that separates the two. If the curve for every liquid at every pressure must be determined experimentally, we are faced with a formidable task. This paper shows that some simplification is possible for members of a homologous group.
Baeza, A.; Corbacho, J. A.
2011-07-01
The determination of total alpha activity by the evaporation method allows obtaining, from a quick and inexpensive technique, the order of magnitude of the total activity of all alpha emitters present in a sample of water. This study shows that the detection efficiency curve varies significantly depending on the sodium salt is used to manufacture calibration and/or reference radionuclide used. (Author)
Rosa, Daniel M. [Universidade de Brasilia (UnB-Gama), DF (Brazil)], E-mail: danielrosa@unb.br; Fadel, Aida A.; Araujo, Jose Alexander; Ferreira, Jorge Luiz A.; Henriques, Antonio Manoel D. [Universidade de Brasilia (EnM/UnB), DF (Brazil). Dept. de Engenharia Mecanica], Emails: aida@unb.br, alex07@unb.br, jorge@unb.br, Henriques@unb.br; Hortencio, Tania M.O.S. [Companhia Energetica de Goias Distribuicao S.A. (CELG D), Goiania, GO (Brazil)], E-mail: tania.hortencio@celg.com.br
2009-07-01
The aim of this work was to present a fretting fatigue experimental rig for overhead conductors and to carry out a set of experiments to obtain life estimative for a standard Ibis ACSR, Aluminium Conductor Steel Reinforced. A preliminary S-N (Wohler) Curve was obtained in the medium high cycle fatigue regime. Experiments considered the occurrence of at least two wire breaks to obtain each point of the S-N curve, which was compared to CIGRE's Safe Border Line (CSBL). The experimental results showed five to ten times large lives than the ones provided by CSBL adoption. (author)
Johnson, L. E.; Kim, J.; Cifelli, R.; Chandra, C. V.
2016-12-01
Potential water retention, S, is one of parameters commonly used in hydrologic modeling for soil moisture accounting. Physically, S indicates total amount of water which can be stored in soil and is expressed in units of depth. S can be represented as a change of soil moisture content and in this context is commonly used to estimate direct runoff, especially in the Soil Conservation Service (SCS) curve number (CN) method. Generally, the lumped and the distributed hydrologic models can easily use the SCS-CN method to estimate direct runoff. Changes in potential water retention have been used in previous SCS-CN studies; however, these studies have focused on long-term hydrologic simulations where S is allowed to vary at the daily time scale. While useful for hydrologic events that span multiple days, the resolution is too coarse for short-term applications such as flash flood events where S may not recover its full potential. In this study, a new method for estimating a time-variable potential water retention at hourly time-scales is presented. The methodology is applied for the Napa River basin, California. The streamflow gage at St Helena, located in the upper reaches of the basin, is used as the control gage site to evaluate the model performance as it is has minimal influences by reservoirs and diversions. Rainfall events from 2011 to 2012 are used for estimating the event-based SCS CN to transfer to S. As a result, we have derived the potential water retention curve and it is classified into three sections depending on the relative change in S. The first is a negative slope section arising from the difference in the rate of moving water through the soil column, the second is a zero change section representing the initial recovery the potential water retention, and the third is a positive change section representing the full recovery of the potential water retention. Also, we found that the soil water moving has traffic jam within 24 hours after finished first
Kayla Poletto
2011-06-01
Full Text Available Understanding hydrosedimental behavior of a watershed is essential for properly managing and using its hydric resources. The objective of this study was to verify the feasibility of the alternative procedure for the indirect determination of the sediment key curve using a turbidimeter. The research was carried out on the São Francisco Falso River, which is situated in the west of the state of Paraná on the left bank of ITAIPU reservoir. The direct method was applied using a DH-48 sediment suspended sampler. The indirect method consisted of the use of a linigraph and a turbidimeter. Based on the results obtained, it was concluded that the indirect method using a turbidimeter showed to be fully feasible, since it gave a power function-type mathematical model equal of the direct method. Furthermore, the average suspended sediment discharge into the São Francisco Falso River during the 2006/2007 harvest was calculated at 7.26 metric t day-1.O conhecimento do comportamento hidrossedimentológico de uma bacia hidrográfica é fundamental para a adequada gestão e uso de seus recursos hídricos. Este trabalho teve o objetivo de verificar a viabilidade de se determinar indiretamente a curva-chave de sedimentos usando como alternativa um turbidímetro. O trabalho foi desenvolvido no Rio São Francisco Falso, situado no oeste do Paraná, na margem esquerda do lago de ITAIPU. O método direto foi realizado usando o molinete e amostrador de sedimentos em suspensão DH-48. O método indireto consistiu no uso de linígrafo e turbidímetro. A partir dos resultados obtidos, foi possível concluir que o método indireto usando um turbidímetro apresentou-se plenamente viável, pois encontrou-se modelo matemático do tipo potencial igual ao método direto. Determinou-se ainda que a descarga média de sedimentos em suspensão no Rio São Francisco Falso, no ano agrícola de 2006/2007, foi de 7,26 t dia-1.
Theoretical Magnon Dispersion Curves for Gd
Lindgård, Per-Anker; Harmon, B. N.; Freeman, A. J.
1975-01-01
The magnon dispersion curve of Gd metal has been determined from first principles by use of augmented-plane-wave energy bands and wave functions. The exchange matrix elements I(k⃗, k⃗′) between the 4f electrons and the conduction electrons from the first six energy bands were calculated under...
Munoz, V.; Rohr, G. A.; Tomba Martinez, A. G.; Cavalieri, A. L.
2011-07-01
A methodology for the mechanical evaluation of refractory materials at high temperatures and controlled atmosphere, designed and implemented in the Structural Materials Laboratory of Ceramics Division of INTEMA, is described. The methodology includes the measurement of the specimen deformation by contact extensometry in compression tests to obtain stress-strain curves and the use of a gaseous flow as a system to control atmosphere. The determination of stress-strain curves of Al{sub 2}O{sub 3}-MgO-C commercial refractories used in steelmaking ladles at room temperature and 1260 degree centigrade in different atmospheres is presented as an example of application of this methodology. (Author) 34 refs.
Brünner, N; Spang-Thomsen, M; Vindeløv, L
1985-01-01
of the treatment was evaluated using growth curves and flow cytometric DNA analysis. The treatment induced a dose-dependent growth delay and dose-dependent changes in the cell cycle distribution. The cell cycle changes comprised a decrease in the G1 phase, an accumulation of cells in the S phase, and an increasing...
Oliveira, Romero Marcilio Barros Matias de
2002-08-01
Biological dosimetry estimates the absorbed dose taking into account changes in biological parameters. The most used biological indicator of an exposition to ionizing radiation is the quantification of chromosomal aberrations of lymphocytes from irradiated individuals. The curves of dose versus induced biological effects, obtained through bionalyses, are used in used in retrospective evaluations of the dose, mainly in the case of accidents. In this research, a simple model for electrons and photons transports was idealized to simulate the irradiation of lymphocytes with {sup 99m} Tc, representing a system used for irradiation of blood cells. The objective of the work was to establish a curve of dose versus frequencies of chromosomal aberrations in lymphocytes of human blood. For the irradiation of blood samples micro spheres of human serum of albumin (HSAM) market with {sup 99m} Tc were used, allowing the irradiation of blood with different administered activities of {sup 99m} Tc, making possible the study the cytogenetical effects as a function of such activities. The conditions of irradiation in vivo using HSAM spheres marked with {sup 99m} Tc were simulated with MCNP 4C (Monte Carlo N-Particle) code to obtain the dose-response curve. Soft tissue composition was employed to simulate blood tissue and the analyses of the curve of dose versus biological effect showed a linear quadratic response of the unstable chromosomal aberrations. As a result, the response of dose versus chromosomal aberrations of blood irradiation with {sup 99m} Tc was best fitted by the curve Y=(8,99 {+-}2,06) x 1-{sup -4} + (1,24 {+-}0,62) x 10{sup -2} D + (5,67 {+-} 0,64) x 10{sup -2} D{sup 2}. (author)
Cubic B-spline curve approximation by curve unclamping
Chen, Xiao-Diao; Ma, Weiyin; Paul, Jean-Claude
2010-01-01
International audience; A new approach for cubic B-spline curve approximation is presented. The method produces an approximation cubic B-spline curve tangent to a given curve at a set of selected positions, called tangent points, in a piecewise manner starting from a seed segment. A heuristic method is provided to select the tangent points. The first segment of the approximation cubic B-spline curve can be obtained using an inner point interpolation method, least-squares method or geometric H...
On curves on sandwiched surface singularities
Fernandez-Sanchez, Jesus
2007-01-01
Fixed a point O on a non-singular surface S and a complete mO-primary ideal I in its local ring, the curves on the surface X obtained by blowing-up I are studied in terms of the base points of I. Criteria for the principality of these curves are obtained. New formulas for their multiplicity, intersection numbers and order of singularity at the singularities of X are given. The semigroup of branches going through a sandwiched singularity is effectively determined, too.
Mathematical design of a highway exit curve
Pakdemirli, Mehmet
2016-01-01
A highway exit curve is designed under the assumption that the tangential and normal components of the acceleration of the vehicle remain constant throughout the path. Using fundamental principles of physics and calculus, the differential equation determining the curve function is derived. The equation and initial conditions are cast into a dimensionless form first for universality of the results. It is found that the curves are effected by only one dimensionless parameter which is the ratio of the tangential acceleration to the normal acceleration. For no tangential acceleration, the equation can be solved analytically yielding a circular arc solution as expected. For nonzero tangential acceleration, the function is complicated and no closed-form solutions exist for the differential equation. The equation is solved numerically for various acceleration ratios. Discussions for applications to highway exits are given.
Minimal families of curves on surfaces
Lubbes, Niels
2014-11-01
A minimal family of curves on an embedded surface is defined as a 1-dimensional family of rational curves of minimal degree, which cover the surface. We classify such minimal families using constructive methods. This allows us to compute the minimal families of a given surface.The classification of minimal families of curves can be reduced to the classification of minimal families which cover weak Del Pezzo surfaces. We classify the minimal families of weak Del Pezzo surfaces and present a table with the number of minimal families of each weak Del Pezzo surface up to Weyl equivalence.As an application of this classification we generalize some results of Schicho. We classify algebraic surfaces that carry a family of conics. We determine the minimal lexicographic degree for the parametrization of a surface that carries at least 2 minimal families. © 2014 Elsevier B.V.
Fuentes Enriquez de Salamanca, S.; Nood, van E.; Tims, S.; Heikamp-de Jong, I.; Braak, ter C.J.F.; Keller, J.J.; Zoetendal, E.G.; Vos, de W.M.
2014-01-01
Recurrent Clostridium difficile infection (CDI) can be effectively treated by infusion of a healthy donor faeces suspension. However, it is unclear what factors determine treatment efficacy. By using a phylogenetic microarray platform, we assessed composition, diversity and dynamics of faecal
Reflection of curved shock waves
Mölder, S.
2017-03-01
Shock curvatures are related to pressure gradients, streamline curvatures and vorticity in flows with planar and axial symmetry. Explicit expressions, in an influence coefficient format, are used to relate post-shock pressure gradient, streamline curvature and vorticity to pre-shock gradients and shock curvature in steady flow. Using higher order, von Neumann-type, compatibility conditions, curved shock theory is applied to calculate the flow near singly and doubly curved shocks on curved surfaces, in regular shock reflection and in Mach reflection. Theoretical curved shock shapes are in good agreement with computational fluid dynamics calculations and experiment.
Reflection of curved shock waves
Mölder, S.
2017-09-01
Shock curvatures are related to pressure gradients, streamline curvatures and vorticity in flows with planar and axial symmetry. Explicit expressions, in an influence coefficient format, are used to relate post-shock pressure gradient, streamline curvature and vorticity to pre-shock gradients and shock curvature in steady flow. Using higher order, von Neumann-type, compatibility conditions, curved shock theory is applied to calculate the flow near singly and doubly curved shocks on curved surfaces, in regular shock reflection and in Mach reflection. Theoretical curved shock shapes are in good agreement with computational fluid dynamics calculations and experiment.
Heegner modules and elliptic curves
Brown, Martin L
2004-01-01
Heegner points on both modular curves and elliptic curves over global fields of any characteristic form the topic of this research monograph. The Heegner module of an elliptic curve is an original concept introduced in this text. The computation of the cohomology of the Heegner module is the main technical result and is applied to prove the Tate conjecture for a class of elliptic surfaces over finite fields; this conjecture is equivalent to the Birch and Swinnerton-Dyer conjecture for the corresponding elliptic curves over global fields.
Closed planar curves without inflections
Ohno, Shuntaro; Umehara, Masaaki
2011-01-01
We define a computable topological invariant $\\mu(\\gamma)$ for generic closed planar regular curves $\\gamma$, which gives an effective lower bound for the number of inflection points on a given generic closed planar curve. Using it, we classify the topological types of locally convex curves (i.e. closed planar regular curves without inflections) whose numbers of crossings are less than or equal to five. Moreover, we discuss the relationship between the number of double tangents and the invariant $\\mu(\\gamma)$ on a given $\\gamma$.
Cylindrical Helix Spline Approximation of Spatial Curves
无
2007-01-01
In this paper, we present a new method for approximating spatial curves with a G1 cylindrical helix spline within a prescribed tolerance. We deduce the general formulation of a cylindrical helix,which has 11 freedoms. This means that it needs 11 restrictions to determine a cylindrical helix. Given a spatial parametric curve segment, including the start point and the end point of this segment, the tangent and the principal normal of the start point, we can always find a cylindrical segment to interpolate the given direction and position vectors. In order to approximate the known parametric curve within the prescribed tolerance, we adopt the trial method step by step. First, we must ensure the helix segment to interpolate the given two end points and match the principal normal and tangent of the start point, and then, we can keep the deviation between the cylindrical helix segment and the known curve segment within the prescribed tolerance everywhere. After the first segment had been formed, we can construct the next segment. Circularly, we can construct the G1 cylindrical helix spline to approximate the whole spatial parametric curve within the prescribed tolerance. Several examples are also given to show the efficiency of this method.
Hu, Zhongya; Hu, Wenxuan; Wang, Xiaomin; Lu, Yizhou; Wang, Lichao; Liao, Zhiwei; Li, Weiqiang
2017-07-01
Magnesium isotopes are an emerging tool to study the geological processes recorded in carbonates. Calcite, due to its ubiquitous occurrence and the large Mg isotope fractionation associated with the mineral, has attracted great interests in applications of Mg isotope geochemistry. However, the fidelity of Mg isotopes in geological records of carbonate minerals (e.g., calcite and dolomite) against burial metamorphism remains poorly constrained. Here we report our investigation on the Mg isotope systematics of a dolomitized Middle Triassic Geshan carbonate section in eastern China. Magnesium isotope analysis was complemented by analyses of Sr-C-O isotopic compositions, major and trace element concentrations, and petrographic and mineralogical features. Multiple lines of evidence consistently indicated that post-depositional diagenesis of carbonate minerals occurred to the carbonate rocks. Magnesium isotope compositions of the carbonate rocks closely follow a mixing trend between a high δ26Mg dolomite end member and a low δ26Mg calcite end member, irrespective of sample positions in the section and calcite/dolomite ratio in the samples. By fitting the measured Mg isotope data using a two-end member mixing model, an inter-mineral Δ26Mgdolomite-calcite fractionation of 0.72‰ was obtained. Based on the experimentally derived Mg isotope fractionation factors for dolomite and calcite, a temperature of 150-190 °C was calculated to correspond to the 0.72‰ Δ26Mgdolomite-calcite fractionation. Such temperature range matches with the burial-thermal history of the local strata, making a successful case of Mg isotope geothermometry. Our results indicate that both calcite and dolomite had been re-equilibrated during burial metamorphism, and based on isotope mass balance of Mg, the system was buffered by dolomite in the section. Therefore, burial metamorphism may reset Mg isotope signature of calcite, and Mg isotope compositions in calcite should be dealt with caution in
Bahram Andarzian
2015-06-01
Full Text Available Wheat production in the south of Khuzestan, Iran is constrained by heat stress for late sowing dates. For optimization of yield, sowing at the appropriate time to fit the cultivar maturity length and growing season is critical. Crop models could be used to determine optimum sowing window for a locality. The objectives of this study were to evaluate the Cropping System Model (CSM-CERES-Wheat for its ability to simulate growth, development, grain yield of wheat in the tropical regions of Iran, and to study the impact of different sowing dates on wheat performance. The genetic coefficients of cultivar Chamran were calibrated for the CSM-CERES-Wheat model and crop model performance was evaluated with experimental data. Wheat cultivar Chamran was sown on different dates, ranging from 5 November to 9 January during 5 years of field experiments that were conducted in the Khuzestan province, Iran, under full and deficit irrigation conditions. The model was run for 8 sowing dates starting on 25 October and repeated every 10 days until 5 January using long-term historical weather data from the Ahvaz, Behbehan, Dezful and Izeh locations. The seasonal analysis program of DSSAT was used to determine the optimum sowing window for different locations as well. Evaluation with the experimental data showed that performance of the model was reasonable as indicated by fairly accurate simulation of crop phenology, biomass accumulation and grain yield against measured data. The normalized RMSE were 3%, 2%, 11.8%, and 3.4% for anthesis date, maturity date, grain yield and biomass, respectively. Optimum sowing window was different among locations. It was opened and closed on 5 November and 5 December for Ahvaz; 5 November and 15 December for Behbehan and Dezful;and 1 November and 15 December for Izeh, respectively. CERES-Wheat model could be used as a tool to evaluate the effect of sowing date on wheat performance in Khuzestan conditions. Further model evaluations
Brücker, Herbert; Jahn, Elke J.
Based on a wage curve approach we examine the labor market effects of migration in Germany. The wage curve relies on the assumption that wages respond to a change in the unemployment rate, albeit imperfectly. This allows one to derive the wage and employment effects of migration simultaneously...
NURBS curve blending using extension
Yong-jin LIU; Rong-qi QIU; Xiao-hui LIANG
2009-01-01
Curve and surface blending is an important operation in CAD systems, in which a non-uniform rational B-spline (NURBS) has been used as the de facto standard. In local comer blending, two curves intersecting at that comer are first made disjoint, and then the third blending curve is added-in to smoothly join the two curves with G1-or G2-continuity. In this paper we present a study to solve the joint problem based on curve extension. The following nice properties of this extension algorithm are exploited in depth: (1) The parameterization of the original shapes does not change; (2) No additional fragments are created.Various examples are presented to demonstrate that our solution is simple and efficient.
Sandra Malmgren Hill
2016-07-01
Full Text Available Age can be reset during mitosis in both yeast and stem cells to generate a young daughter cell from an aged and deteriorated one. This phenomenon requires asymmetry-generating genes (AGGs that govern the asymmetrical inheritance of aggregated proteins. Using a genome-wide imaging screen to identify AGGs in Saccharomyces cerevisiae, we discovered a previously unknown role for endocytosis, vacuole fusion, and the myosin-dependent adaptor protein Vac17 in asymmetrical inheritance of misfolded proteins. Overproduction of Vac17 increases deposition of aggregates into cytoprotective vacuole-associated sites, counteracts age-related breakdown of endocytosis and vacuole integrity, and extends replicative lifespan. The link between damage asymmetry and vesicle trafficking can be explained by a direct interaction between aggregates and vesicles. We also show that the protein disaggregase Hsp104 interacts physically with endocytic vesicle-associated proteins, such as the dynamin-like protein, Vps1, which was also shown to be required for Vac17-dependent sequestration of protein aggregates. These data demonstrate that two physiognomies of aging—reduced endocytosis and protein aggregation—are interconnected and regulated by Vac17.
Bandyopadhyay, Promode R.; Hellum, Aren M.
2014-10-01
Many slow-moving biological systems like seashells and zebrafish that do not contend with wall turbulence have somewhat organized pigmentation patterns flush with their outer surfaces that are formed by underlying autonomous reaction-diffusion (RD) mechanisms. In contrast, sharks and dolphins contend with wall turbulence, are fast swimmers, and have more organized skin patterns that are proud and sometimes vibrate. A nonlinear spatiotemporal analytical model is not available that explains the mechanism underlying control of flow with such proud patterns, despite the fact that shark and dolphin skins are major targets of reverse engineering mechanisms of drag and noise reduction. Comparable to RD, a minimal self-regulation model is given for wall turbulence regeneration in the transitional regime--laterally coupled, diffusively--which, although restricted to pre-breakdown durations and to a plane close and parallel to the wall, correctly reproduces many experimentally observed spatiotemporal organizations of vorticity in both laminar-to-turbulence transitioning and very low Reynolds number but turbulent regions. We further show that the onset of vorticity disorganization is delayed if the skin organization is treated as a spatiotemporal template of olivo-cerebellar phase reset mechanism. The model shows that the adaptation mechanisms of sharks and dolphins to their fluid environment have much in common.
Caccia, M.; Santoro, R.; Antonello, M.
2017-03-01
The SUCIMA collaboration, within a project supported by the European Commission in the Fifth Framework Program, developed a sensor for non-disruptive real-time beam profilometry for hadron therapy centres. The sensor, named MIMOTERA, has been used at different European facilities, imaging beams by direct impact on the sensor and by the detection of secondary electrons emitted by thin targets. In 2015, the detector has been thinned to 50 μm, integrated in a high vacuum and cryogenic temperature compliant assembly and successfully commissioned as antiproton beam monitor for the AEbar gIS experiment at CERN. The detector contributed to the optimisation of the experiment functionality providing the shape and position of the beam on a spill-by-spill basis. However, it failed in measuring the fluctuations of the beam intensity because the deposited energy exceeded the full well capacity and saturated the output signal. In order to recover this information, a method was developed based on the persistence of the signal in a series of frames that follows the one corresponding to the beam impact, due to the incomplete sensor reset. A laboratory test that makes use of a laser with tuneable intensity was designed and the method was qualified. This paper reports the description of the procedure and the main outcomes.
Nathan W Gouwens
Full Text Available Fast-spiking (FS cells in the neocortex are interconnected both by inhibitory chemical synapses and by electrical synapses, or gap-junctions. Synchronized firing of FS neurons is important in the generation of gamma oscillations, at frequencies between 30 and 80 Hz. To understand how these synaptic interactions control synchronization, artificial synaptic conductances were injected in FS cells, and the synaptic phase-resetting function (SPRF, describing how the compound synaptic input perturbs the phase of gamma-frequency spiking as a function of the phase at which it is applied, was measured. GABAergic and gap junctional conductances made distinct contributions to the SPRF, which had a surprisingly simple piecewise linear form, with a sharp midcycle break between phase delay and advance. Analysis of the SPRF showed how the intrinsic biophysical properties of FS neurons and their interconnections allow entrainment of firing over a wide gamma frequency band, whose upper and lower frequency limits are controlled by electrical synapses and GABAergic inhibition respectively.
Estimation of the Bezout number for piecewise algebraic curve
WANG; Renhong(王仁宏); XU; Zhiqiang(许志强)
2003-01-01
A piecewise algebraic curve is a curve determined by the zero set of a bivariate spline function.In this paper, a conjecture on triangulation is confirmed. The relation between the piecewise linear algebraiccurve and four-color conjecture is also presented. By Morgan-Scott triangulation, we will show the instabilityof Bezout number of piecewise algebraic curves. By using the combinatorial optimization method, an upperbound of the Bezout number defined as the maximum finite number of intersection points of two piecewisealgebraic curves is presented.
基于MSP430的硒鼓芯片复位装置的设计%Design of Cartridge Chip Reset Device Based on MSP430
高广; 何美玲; 俎全高; 周敏
2011-01-01
Aiming at that the printing supplies for laser toner cartridge manufacturer in the production process are needed to resolve the problem of cartridge chip re-use issues, a cartridge chip reset device based on MSP430 is designed. Different types of toner cartridge chips can be reset by the device, so that the cartridge chips can be recycled in order to achieving production cost savings, protecting the environment. The device also has a good reset effect, the advantages of easy operation.%针对激光打印耗材生产厂家硒鼓生产过程中需对硒鼓芯片进行再利用的问题,设计了一种基于MSP430的硒鼓芯片复位装置.利用该装置可以复位不同型号的硒鼓芯片,从而使硒鼓芯片可循环利用,以达到节约生产成本、保护环境的目的.该装置同时具有复位效果好、易于操作的优点.
Chen, Xiaorong; Feng, Jie [Shanghai Jiao Tong University, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Department of Micro/Nano Electronics, Shanghai (China)
2015-07-15
Improvements in the R{sub off}/R{sub on} ratio and reset current are required prior to the practical application of RRAM. To achieve this improvement, tantalum oxide-based RRAM devices with multilayer structure (bi-layer and tri-layer) were fabricated and various compliance currents were adopted. The reset current of 40 μA was observed; the R{sub off}/R{sub on} ratio increased to more than 20 in the tri-layer structure device. Resistance changes in two types of devices under voltage pulses with different pulse width were also conducted. The tri-layer device exhibited lower reset voltage and higher R{sub off}/R{sub on} ratio than the bi-layer device under voltage pulses. X-ray photoelectron spectroscopy demonstrated the formation of Ta{sub 2}O{sub 5} via plasma oxidation, and there was an oxygen gradient in the multilayer devices. The results demonstrated that the tri-layer structure with oxygen gradient was an effective method for achieving better device performance. Additionally, it is implied that reasonable control of the proportion of TaO{sub 2} and Ta{sub 2}O{sub 5} and compliance current can improve device performance. (orig.)
Nagano, Mamoru; Adachi, Akihito; Masumoto, Koh-hei; Meyer-Bernstein, Elizabeth; Shigeyoshi, Yasufumi
2009-09-15
Photic resetting of a biological clock is one of the fundamental characteristics of circadian systems and allows living organisms to adjust to a particular environment. Nocturnal light induces the Per1 and Per2 genes, which leads to a resetting of the circadian clock in the suprachiasmatic nucleus (SCN), the mammalian circadian center. In our present study, we investigated whether light differentially induces the rat Per1 (rPer1) and Per2 (rPer2) genes to enable resetting of their circadian clocks. In a 24-hour LD cycle (12 h light:12 h dark), which is shorter than the normal free-running period for rats, Per1 alone showed strong induction in the ventrolateral region of the SCN (VLSCN) during the early day. In contrast, in a 25 hour LD cycle (12.5 h light:12.5 h dark), which is longer than the free running period for these animals, rPer2 alone was strongly induced in the VLSCN, at the end of the light phase and during the early dark periods. Our current findings therefore suggest that Per1 and Per2 are differentially regulated for daily entrainment to the LD cycle.
Parameter Deduction and Accuracy Analysis of Track Beam Curves in Straddle-type Monorail Systems
Xiaobo Zhao
2015-12-01
Full Text Available The accuracy of the bottom curve of a PC track beam is strongly related to the production quality of the entire beam. Many factors may affect the parameters of the bottom curve, such as the superelevation of the curve and the deformation of a PC track beam. At present, no effective method has been developed to determine the bottom curve of a PC track beam; therefore, a new technique is presented in this paper to deduce the parameters of such a curve and to control the accuracy of the computation results. First, the domain of the bottom curve of a PC track beam is assumed to be a spindle plane. Then, the corresponding supposed top curve domain is determined based on a geometrical relationship that is the opposite of that identified by the conventional method. Second, several optimal points are selected from the supposed top curve domain according to the dichotomy algorithm; the supposed top curve is thus generated by connecting these points. Finally, one rigorous criterion is established in the fractal dimension to assess the accuracy of the assumed top curve deduced in the previous step. If this supposed curve coincides completely with the known top curve, then the assumed bottom curve corresponding to the assumed top curve is considered to be the real bottom curve. This technique of determining the bottom curve of a PC track beam is thus proven to be efficient and accurate.
A Unified Algorithm for Finding the Intersection Curve of Surfaces
谭建荣; 郑建民; 等
1994-01-01
In this papaer,an INTEGRAL CURVE ALGORITHM is presented,which turns the intersection curve of surfaces into the form of integral one and then uses “PREDICTORCORRECTOR” technique to evaluate the intersection of surfaces.No matter how the surfaces are defined,the method always deals with the intersection curves in the same way.To find a point on the curve one need only to calculate the JACOBI determinants of “PREDICTOR point”and “CORRECTOR point” while the second order precision is guatanteed.Thus,not only is the problem of finding the intersection of surfaces resolved,but also the algorithms for generating both plane curve and space curve are unified.
Suitable Conditions of Reservoir Simulation for Searching Rule Curves
Kangrang, Anongrit; Chaleeraktrakoon, Chavalit
The objective of this study is to carry out a suitable length of inflow record using in the simulation model. The second objective is to find an effect of initial reservoir capacity of reservoir simulation for searching the optimal rule curves. The reservoir simulation model was connected with genetic algorithms to search the optimal rule curves quickly. The model has been applied to determine the optimal rule curves of the Bhumibol and Sirikit Reservoirs (the Chao Phraya River Basin, Thailand). The optimal rule curves of each condition were used to assess by a Monte Carlo simulation. The results show that the shortest period of dry inflow record using in the simulation model in order to search the optimal rule curves is 10 year. Furthermore, the minimum initial capacity of reservoir for searching optimal rule curves is 10% of full capacity.
Water retention curve for hydrate-bearing sediments
Dai, Sheng; Santamarina, J. Carlos
2013-11-01
water retention curve plays a central role in numerical algorithms that model hydrate dissociation in sediments. The determination of the water retention curve for hydrate-bearing sediments faces experimental difficulties, and most studies assume constant water retention curves regardless of hydrate saturation. This study employs network model simulation to investigate the water retention curve for hydrate-bearing sediments. Results show that (1) hydrate in pores shifts the curve to higher capillary pressures and the air entry pressure increases as a power function of hydrate saturation; (2) the air entry pressure is lower in sediments with patchy rather than distributed hydrate, with higher pore size variation and pore connectivity or with lower specimen slenderness along the flow direction; and (3) smaller specimens render higher variance in computed water retention curves, especially at high water saturation Sw > 0.7. Results are relevant to other sediment pore processes such as bioclogging and mineral precipitation.
Equations of hyperelliptic Shimura curves
Molina, Santiago
2010-01-01
We describe an algorithm that computes explicit models of hyperelliptic Shimura curves attached to an indefnite quaternion algebra over Q and Atkin-Lehner quotients of them. It exploits Cerednik-Drinfeld's non-archimedean uniformisation of Shimura curves, a formula of Gross and Zagier for the endomorphism ring of Heegner points over Artinian rings and the connection between Ribet's bimodules and the specialization of Heegner points. As an application, we provide a list of equations of Shimura curves and quotients of them obtained by our algorithm that had been conjectured by Kurihara.
Poiseuille flow in curved spaces
Debus, J -D; Succi, S; Herrmann, H J
2015-01-01
We investigate Poiseuille channel flow through intrinsically curved (campylotic) media, equipped with localized metric perturbations (campylons). To this end, we study the flux of a fluid driven through the curved channel in dependence of the spatial deformation, characterized by the campylon parameters (amplitude, range and density). We find that the flux depends only on a specific combination of campylon parameters, which we identify as the average campylon strength, and derive a universal flux law for the Poiseuille flow. For the purpose of this study, we have improved and validated our recently developed lattice Boltzmann model in curved space by considerably reducing discrete lattice effects.
Navigation in Curved Space-Time
Bahder, T B
2001-01-01
A covariant and invariant theory of navigation in curved space-time with respect to electromagnetic beacons is written in terms of J. L. Synge's two-point invariant world function. Explicit equations are given for navigation in space-time in the vicinity of the Earth in Schwarzschild coordinates and in rotating coordinates. The restricted problem of determining an observer's coordinate time when their spatial position is known is also considered.
Activation-induced resetting of cerebral oxygen and glucose uptake in the rat
Madsen, P L; Linde, R; Hasselbalch, S G
1998-01-01
In the clinical setting it has been shown that activation will increase cerebral glucose uptake in excess of cerebral oxygen uptake. To study this phenomenon further, this study presents an experimental setup that enables precise determination of the ratio between cerebral uptake of glucose...... and oxygen in the awake rat. Global CBF was measured by the Kety-Schmidt technique, and the ratio between cerebral uptake rates for oxygen, glucose, and lactate was calculated from cerebral arterial-venous differences. During baseline conditions, rats were kept in a closed box designed to minimize...... interference. During baseline conditions CBF was 1.08 +/- 0.25 mL x g(-1) x minute(-1), and the cerebral oxygen to glucose uptake ratio was 5.5. Activation was induced by opening the sheltering box for 6 minutes. Activation increased CBF to 1.81 mL x g(-1) x minute(-1). During activation cerebral glucose...
Description of dose response curve
Al-Samarai, Firas
2011-01-01
The book included several methods to estimate LD50, in addition to explain how to use several programs to estimate LD50. Moreover the book illustrate the description of the dose response curves. Firas Al-Samarai
Normal origamis of Mumford curves
Kremer, Karsten
2010-01-01
An origami (also known as square-tiled surface) is a Riemann surface covering a torus with at most one branch point. Lifting two generators of the fundamental group of the punctured torus decomposes the surface into finitely many unit squares. By varying the complex structure of the torus one obtains easily accessible examples of Teichm\\"uller curves in the moduli space of Riemann surfaces. The p-adic analogues of Riemann surfaces are Mumford curves. A p-adic origami is defined as a covering of Mumford curves with at most one branch point, where the bottom curve has genus one. A classification of all normal non-trivial p-adic origamis is presented and used to calculate some invariants. These can be used to describe p-adic origamis in terms of glueing squares.
String networks as tropical curves
Ray, Koushik
2008-01-01
A prescription for obtaining supergravity solutions for planar (p,q)-string networks is presented, based on earlier results. It shows that networks may be looked upon as tropical curves emerging as the spine of the amoeba of a holomorphic curve in M-theory. The Kaehler potential of supergravity is identified with the corresponding Ronkin function. Implications of this identification in counting dyons is discussed.
Growth curves for Laron syndrome.
Laron, Z; Lilos, P; Klinger, B.
1993-01-01
Growth curves for children with Laron syndrome were constructed on the basis of repeated measurements made throughout infancy, childhood, and puberty in 24 (10 boys, 14 girls) of the 41 patients with this syndrome investigated in our clinic. Growth retardation was already noted at birth, the birth length ranging from 42 to 46 cm in the 12/20 available measurements. The postnatal growth curves deviated sharply from the normal from infancy on. Both sexes showed no clear pubertal spurt. Girls co...
Flow over riblet curved surfaces
Loureiro, J B R; Freire, A P Silva, E-mail: atila@mecanica.ufrj.br [Mechanical Engineering Program, Federal University of Rio de Janeiro (COPPE/UFRJ), C.P. 68503, 21.941-972, Rio de Janeiro, RJ (Brazil)
2011-12-22
The present work studies the mechanics of turbulent drag reduction over curved surfaces by riblets. The effects of surface modification on flow separation over steep and smooth curved surfaces are investigated. Four types of two-dimensional surfaces are studied based on the morphometric parameters that describe the body of a blue whale. Local measurements of mean velocity and turbulence profiles are obtained through laser Doppler anemometry (LDA) and particle image velocimetry (PIV).
Wu, Tao; Dong, Yue; Yang, Zhiqiu; Kato, Hisanori; Ni, Yinhua; Fu, Zhengwei
2009-07-01
Although studies involving the circadian response to time-zone transitions indicate that the circadian clock usually takes much longer to phase advance than delay, the discrepancy between the circadian resetting induced by photoperiod alteration via a dark or light period transition has yet to be investigated. In mammals, the pineal gland is an important component in the photoneuroendocrine axis, regulating biological rhythms. However, few studies have systematically examined the resetting process of pineal clock-gene expression to date. We investigated the resetting processes of four clock genes (Bmal1, Cry1, Per1, Dec1) and AANAT in the rat pineal gland after the light-dark (LD) reversal via a 24 h light or dark period transition. The resynchronization of the SCN-driven gene AANAT was nearly complete in three days in both situations, displaying similar resetting rates and processes after the differential LD reversals. The resetting processes of the clock genes were characterized by gene-specific, phase-shift modes and differential phase-shift rates between the two different LD reversal modes. The resetting processes of these clock genes were noticeably lengthened after the LD reversal via the light period transition in comparison to via the dark period transition. In addition, among the four examined clock genes, Per1 adjusted most rapidly after the differential LD reversals, while the rhythmic Cry1 expression adjusted most slowly.
The Automorphism Groups of a Family of Maximal Curves
Guralnick, Robert; Pries, Rachel
2011-01-01
The Hasse Weil bound restricts the number of points of a curve which are defined over a finite field; if the number of points meets this bound, the curve is called maximal. Giulietti and Korchmaros introduced a curve C_3 which is maximal over F_{q^6} and determined its automorphism group. Garcia, Guneri, and Stichtenoth generalized this construction to a family of curves C_n, indexed by an odd integer n greater than or equal to 3, such that C_n is maximal over F_{q^{2n}}. In this paper, we determine the automorphism group Aut(C_n) when n > 3; in contrast with the case n=3, it fixes the point at infinity on C_n. The proof requires a new structural result about automorphism groups of curves in characteristic p such that each Sylow p-subgroup has exactly one fixed point. MSC:11G20, 14H37.
Linear Systems on Tropical Curves
Haase, Christian; Yu, Josephine
2009-01-01
A tropical curve \\Gamma is a metric graph with possibly unbounded edges, and tropical rational functions are continuous piecewise linear functions with integer slopes. We define the complete linear system |D| of a divisor D on a tropical curve \\Gamma analogously to the classical counterpart. We investigate the structure of |D| as a cell complex and show that linear systems are quotients of tropical modules, finitely generated by vertices of the cell complex. Using a finite set of generators, |D| defines a map from \\Gamma to a tropical projective space, and the image can be extended to a tropical curve of degree equal to \\deg(D). The tropical convex hull of the image realizes the linear system |D| as a polyhedral complex. We show that curves for which the canonical divisor is not very ample are hyperelliptic. We also show that the Picard group of a \\Q-tropical curve is a direct limit of critical groups of finite graphs converging to the curve.
Telomere length is inherited with resetting of the telomere set-point.
Chiang, Y Jeffrey; Calado, Rodrigo T; Hathcock, Karen S; Lansdorp, Peter M; Young, Neal S; Hodes, Richard J
2010-06-01
We have studied models of telomerase haploinsufficiency in humans and mice to analyze regulation of telomere length and the significance of "set points" in inheritance of telomere length. In three families with clinical syndromes associated with short telomeres resulting from haploinsufficient mutations in TERT, the gene encoding telomerase reverse transcriptase, we asked whether restoration of normal genotypes in offspring of affected individuals would elongate inherited short telomeres. Telomeres were shorter than normal in some but not all genotypically normal offspring of telomerase-mutant parents or grandparents. Analysis of these findings was complicated by heterogeneity of telomere length among individuals, as well as by the admixing of telomeres inherited from affected parents with those inherited from unaffected ("wild-type" TERT) parents. To understand further the inheritance of telomere length, we established a shortened-telomere mouse model. When Tert(+/-) heterozygous mice were successively cross-bred through 17 generations, telomere length shortened progressively. The late-generation Tert(+/-) mice were intercrossed to produce genotypically wild-type Tert(+/+) mice, for which telomere length was characterized. Strikingly, telomere length in these Tert(+/+) mice was not longer than that of their Tert(+/-) parents. Moreover, when successive crosses were carried out among these short-telomere Tert(+/+) offspring mice, telomere length was stable, with no elongation up to six generations. This breeding strategy therefore has established a mouse strain, B6.ST (short telomeres), with C57BL/6 genotype and stable short telomeres. These findings suggest that the set point of telomere lengths of offspring is determined by the telomere lengths of their parents in the presence of normal expression of telomerase.
Modelling Growth Curves in a Nondescript Italian Chicken Breed
Maria Selvaggi; Vito Laudadio; Cataldo Dario; Vincenzo Tufarelli
2015-01-01
... it. This study was carried out to estimate the parameters of logistic, Gompertz and Richards growth curve models in a nondescript chicken breed population from southern Italy to determine the goodness of fit...
More Unusual Light Curves from Kepler
Kohler, Susanna
2017-03-01
-main-sequence stars ever obtained.In these light curves, Stauffer and collaborators found a set of 23 very low-mass, mid-to-late-type M dwarfs with unusual variability in their light curves. The variability is consistent with the stars rotation period where measured which suggests that whatever causes the dips in the light curve, its orbiting at the same rate as the star spins.Causes of Variability?These plots show how the properties of these 23 stars compare to those of the rest of the stars in their cluster (click for a closer look!). For all but the rotation rate, they are typical. But the stars with scallop-shaped light curves have among the shortest periods in Upper Sco, with somenear the theoretical break-up for stars of their age. [Stauffer et al. 2017]The authors categorize the 23 stars into two main groups.The first group consists of 19 stars with short periods; more than half of them rotate within a factor of two of their predicted breakup period! Many of these show sudden changes in their light-curve morphology, often after a stellar flare. The authors propose that the variability in these light curves might be caused by warm coronal gas clouds that are organized into a structured toroidal shape around the star.The second group consists of the remaining four stars, which have slightly longer periods. The light curves show a single short-duration flux dip with highly variable depth and shape superposed on normal, spotted-star light curves. The authors best guess for these four stars is that there are clouds of dusty debris circling the star, possibly orbiting a close-in planet or resulting from a recent collisional event.Stauffer and collaborators are currently developing more detailed models for these stars based on the possible variability scenarios. The next step, they state, is to determine if the gas in these structures have properties necessary to generate the light-curve features we see.CitationJohn Stauffer et al 2017 AJ 153 152. doi:10.3847/1538-3881/aa5eb9
Maturity assessment and curve progression in girls with idiopathic scoliosis.
Sanders, James O; Browne, Richard H; McConnell, Sharon J; Margraf, Susan A; Cooney, Timothy E; Finegold, David N
2007-01-01
Scoliosis progression during adolescence is closely related to patient maturity. Maturity has various indicators, including chronological age, height and weight changes, and skeletal and sexual maturation. It is not certain which of these indicators correlates most strongly with scoliosis progression. The purpose of the present study was to evaluate various maturity measurements and how they relate to scoliosis progression. Physically immature girls with idiopathic scoliosis were evaluated every six months through their growth spurt with serial spinal radiographs; hand skeletal ages; Oxford pelvic scores; Risser sign determinations; height; weight; sexual staging; and serologic studies of the levels of selected growth factors, estradiol, bone-specific alkaline phosphatase, and osteocalcin. These measurements were then correlated with the curve-acceleration phase. The period and pattern of curve acceleration began during Risser stage 0 for all patients. Skeletal maturation scores derived with the use of the Tanner-Whitehouse-III RUS method, particularly those for the metacarpals and phalanges, were superior to all other indicators of maturity. Regression of the scores provided good estimates of maturity relative to the period of curve progression (Pearson r = 0.93). The initiation of this period occurred simultaneously with digital changes from Tanner-Whitehouse-III stage F to G. At this stage, curves also separated into rapid, moderate, and low-acceleration patterns, with specific curve types in the rapid and moderate-acceleration groups. The low-acceleration group was not confined to a specific curve type. The curve-acceleration phase separates curves into various types of curve progression. The Tanner-Whitehouse-III RUS scores are highly correlated with timing relative to the curve-acceleration phase and provide better maturity determination and prognosis determination during adolescence than the other parameters tested. Accurate skeletal maturity determination
BUTCHER,T.A.
2004-10-01
Use of condensing boilers in residential heating systems offers the potential for significant improvements in efficiency. For these to operate in a condensing mode the return water temperature needs to be about 10 degrees below the saturation temperature for the flue gas water vapor. This saturation temperature depends on fuel type and excess air and ranges from about 110 F to 135 F. Conventional baseboard hydronic distribution systems are most common and these are designed for water temperatures in the 180 F range, well above the saturation temperature. Operating strategies which may allow these systems to operate in a condensing mode have been considered in the past. In this study an approach to achieving this for a significant part of the heating season has been tested in an instrumented home. The approach involves use of an outdoor reset control which reduces the temperature of the water circulating in the hydronic loop when the outdoor temperature is higher than the design point for the region. Results showed that this strategy allows the boiler to operate in the condensing region for 80% of the winter heating season with oil, 90% with propane, and 95% with gas, based on cumulative degree days. The heating system as tested combines space heating and domestic hot water loads using an indirect, 40 gallon tank with an internal heat exchanger. Tests conducted during the summer months showed that the return water temperature from the domestic hot water tank heat exchanger is always below a temperature which will provide condensing operation of the boiler. In the field tests both the condensing boiler and the conventional, non-condensing boiler were in the test home and each was operated periodically to provide a direct performance comparison.
Friedman, Michael; Miranda-Massari, Jorge R; Gonzalez, Michael J
2006-03-01
The use of sustained release tri-iodothyronine (SR-T3) in clinical practice, has gained popularity in the complementary and alternative medical community in the treatment of chronic fatigue with a protocol (WT3) pioneered by Dr. Denis Wilson. The WT3 protocol involves the use of SR-T3 taken orally by the patient every 12 hours according to a cyclic dose schedule determined by patient response. The patient is then weaned once a body temperature of 98.6 degrees F has been maintained for 3 consecutive weeks. The symptoms associated with this protocol have been given the name Wilson's Temperature Syndrome (WTS). There have been clinical studies using T3 in patients who are euthyroid based on normal TSH values. However, this treatment has created a controversy in the conventional medical community, especially with the American Thyroid Association, because it is not based on a measured deficiency of thyroid hormone. However, just as estrogen and progesterone are prescribed to regulate menstrual cycles in patients who have normal serum hormone levels, the WT3 therapy can be used to regulate metabolism despite normal serum thyroid hormone levels. SR-T3 prescription is based exclusively on low body temperature and presentation of symptoms. Decreased T3 function exerts widespread effects throughout the body. It can decrease serotonin and growth hormone levels and increase the number of adrenal hormone receptor sites. These effects may explain some of the symptoms observed in WTS. The dysregulation of neuroendocrine function may begin to explain such symptoms as alpha intrusion into slow wave sleep, decrease in blood flow to the brain, alterations in carbohydrate metabolism, fatigue, myalgia and arthralgia, depression and cognitive dysfunction. Despite all thermoregulatory control mechanisms of the body and the complex metabolic processes involved, WT3 therapy seems a valuable tool to re-establish normal body functions. We report the results of 11 patients who underwent the
Modeling and Fitting Exoplanet Transit Light Curves
Millholland, Sarah; Ruch, G. T.
2013-01-01
We present a numerical model along with an original fitting routine for the analysis of transiting extra-solar planet light curves. Our light curve model is unique in several ways from other available transit models, such as the analytic eclipse formulae of Mandel & Agol (2002) and Giménez (2006), the modified Eclipsing Binary Orbit Program (EBOP) model implemented in Southworth’s JKTEBOP code (Popper & Etzel 1981; Southworth et al. 2004), or the transit model developed as a part of the EXOFAST fitting suite (Eastman et al. in prep.). Our model employs Keplerian orbital dynamics about the system’s center of mass to properly account for stellar wobble and orbital eccentricity, uses a unique analytic solution derived from Kepler’s Second Law to calculate the projected distance between the centers of the star and planet, and calculates the effect of limb darkening using a simple technique that is different from the commonly used eclipse formulae. We have also devised a unique Monte Carlo style optimization routine for fitting the light curve model to observed transits. We demonstrate that, while the effect of stellar wobble on transit light curves is generally small, it becomes significant as the planet to stellar mass ratio increases and the semi-major axes of the orbits decrease. We also illustrate the appreciable effects of orbital ellipticity on the light curve and the necessity of accounting for its impacts for accurate modeling. We show that our simple limb darkening calculations are as accurate as the analytic equations of Mandel & Agol (2002). Although our Monte Carlo fitting algorithm is not as mathematically rigorous as the Markov Chain Monte Carlo based algorithms most often used to determine exoplanetary system parameters, we show that it is straightforward and returns reliable results. Finally, we show that analyses performed with our model and optimization routine compare favorably with exoplanet characterizations published by groups such as the
Curve Digitizer – A software for multiple curves digitizing
Florentin ŞPERLEA
2010-06-01
Full Text Available The Curve Digitizer is software that extracts data from an image file representing a graphicand returns them as pairs of numbers which can then be used for further analysis and applications.Numbers can be read on a computer screen stored in files or copied on paper. The final result is adata set that can be used with other tools such as MSEXCEL. Curve Digitizer provides a useful toolfor any researcher or engineer interested in quantifying the data displayed graphically. The image filecan be obtained by scanning a document
Variation of curve number with storm depth
Banasik, K.; Hejduk, L.
2012-04-01
The NRCS Curve Number (known also as SCS-CN) method is well known as a tool in predicting flood runoff depth from small ungauged catchment. The traditional way of determination the CNs, based on soil characteristics, land use and hydrological conditions, seemed to have tendency to overpredict the floods in some cases. Over 30 year rainfall-runoff data, collected in two small (A=23.4 & 82.4 km2), lowland, agricultural catchments in Center of Poland (Banasik & Woodward 2010), were used to determine runoff Curve Number and to check a tendency of changing. The observed CN declines with increasing storm size, which according recent views of Hawkins (1993) could be classified as a standard response of watershed. The analysis concluded, that using CN value according to the procedure described in USDA-SCS Handbook one receives representative value for estimating storm runoff from high rainfall depths in the analyzes catchments. This has been confirmed by applying "asymptotic approach" for estimating the watershed curve number from the rainfall-runoff data. Furthermore, the analysis indicated that CN, estimated from mean retention parameter S of recorded events with rainfall depth higher than initial abstraction, is also approaching the theoretical CN. The observed CN, ranging from 59.8 to 97.1 and from 52.3 to 95.5, in the smaller and the larger catchment respectively, declines with increasing storm size, which has been classified as a standard response of watershed. The investigation demonstrated also changeability of the CN during a year, with much lower values during the vegetation season. Banasik K. & D.E. Woodward (2010). "Empirical determination of curve number for a small agricultural watrshed in Poland". 2nd Joint Federal Interagency Conference, Las Vegas, NV, June 27 - July 1, 2010 (http://acwi.gov/sos/pubs/2ndJFIC/Contents/10E_Banasik_ 28_02_10. pdf). Hawkins R. H. (1993). "Asymptotic determination of curve numbers from data". Journal of Irrigation and Drainage
THE FLOW IN ROTATING CURVED CIRCULAR PIPE
无
2000-01-01
The combined effects of the system rotation (Coriolis force) and curvature (centrifugal force) on the flow in rotating curved circular pipe with small curvature are examined by perturbation method. A second-order perturbation solution is presented. The secondary flow structure and the primary axial velocity distributions are studied in detail. The loops of the secondary flow are more complex than those in a curved pipe without rotation or a rotating straight pipe. Its numbers depend on the body force ratio F which represents the ratio of the Coriolis to the centrifugal force. The maximum of the axial velocity is pushed to either outer bend or inner bend, which is also determined by F. The results are confirmed by the results of other authors who studied the same problem by different methods.
Topological recursion and mirror curves
Bouchard, Vincent
2012-01-01
We study the constant contributions to the free energies obtained through the topological recursion applied to the complex curves mirror to toric Calabi-Yau threefolds. We show that the recursion reproduces precisely the corresponding Gromov-Witten invariants, which can be encoded in powers of the MacMahon function. As a result, we extend the scope of the "remodeling conjecture" to the full free energies, including the constant contributions. In the process we study how the pair of pants decomposition of the mirror curves plays an important role in the topological recursion. We also show that the free energies are not, strictly speaking, symplectic invariants, and that the recursive construction of the free energies does not commute with certain limits of mirror curves.
Laffer Curves and Home Production
Kotamäki Mauri
2017-06-01
Full Text Available In the earlier related literature, consumption tax rate Laffer curve is found to be strictly increasing (see Trabandt and Uhlig (2011. In this paper, a general equilibrium macro model is augmented by introducing a substitute for private consumption in the form of home production. The introduction of home production brings about an additional margin of adjustment – an increase in consumption tax rate not only decreases labor supply and reduces the consumption tax base but also allows a substitution of market goods with home-produced goods. The main objective of this paper is to show that, after the introduction of home production, the consumption tax Laffer curve exhibits an inverse U-shape. Also the income tax Laffer curves are significantly altered. The result shown in this paper casts doubt on some of the earlier results in the literature.
Rational points on elliptic curves
Silverman, Joseph H
2015-01-01
The theory of elliptic curves involves a pleasing blend of algebra, geometry, analysis, and number theory. This book stresses this interplay as it develops the basic theory, thereby providing an opportunity for advanced undergraduates to appreciate the unity of modern mathematics. At the same time, every effort has been made to use only methods and results commonly included in the undergraduate curriculum. This accessibility, the informal writing style, and a wealth of exercises make Rational Points on Elliptic Curves an ideal introduction for students at all levels who are interested in learning about Diophantine equations and arithmetic geometry. Most concretely, an elliptic curve is the set of zeroes of a cubic polynomial in two variables. If the polynomial has rational coefficients, then one can ask for a description of those zeroes whose coordinates are either integers or rational numbers. It is this number theoretic question that is the main subject of this book. Topics covered include the geometry and ...
Canonical curves with low apolarity
Ballico, Edoardo; Notari, Roberto
2010-01-01
Let $k$ be an algebraically closed field and let $C$ be a non--hyperelliptic smooth projective curve of genus $g$ defined over $k$. Since the canonical model of $C$ is arithmetically Gorenstein, Macaulay's theory of inverse systems allows to associate to $C$ a cubic form $f$ in the divided power $k$--algebra $R$ in $g-2$ variables. The apolarity of $C$ is the minimal number $t$ of linear form in $R$ needed to write $f$ as sum of their divided power cubes. It is easy to see that the apolarity of $C$ is at least $g-2$ and P. De Poi and F. Zucconi classified curves with apolarity $g-2$ when $k$ is the complex field. In this paper, we give a complete, characteristic free, classification of curves $C$ with apolarity $g-1$ (and $g-2$).
Szpak, Nikodem
2014-01-01
We present some new ideas on how to design analogue models of quantum fields living in curved spacetimes using ultra-cold atoms in optical lattices. We discuss various types of static and dynamical curved spacetimes achievable by simple manipulations of the optical setup. Examples presented here contain two-dimensional spaces of positive and negative curvature as well as homogeneous cosmological models and metric waves. Most of them are extendable to three spatial dimensions. We mention some interesting phenomena of quantum field theory in curved spacetimes which might be simulated in such optical lattices loaded with bosonic or fermionic ultra-cold atoms. We also argue that methods of differential geometry can be used, as an alternative mathematical approach, for dealing with realistic inhomogeneous optical lattices.
The New Keynesian Phillips Curve
Ólafsson, Tjörvi
This paper provides a survey on the recent literature on the new Keynesian Phillips curve: the controversies surrounding its microfoundation and estimation, the approaches that have been tried to improve its empirical fit and the challenges it faces adapting to the open-economy framework. The new...... Keynesian Phillips curve has been severely criticized for poor empirical dynamics. Suggested improvements involve making some adjustments to the standard sticky price framework, e.g. introducing backwardness and real rigidities, or abandoning the sticky price model and relying on models of inattentiveness......, learning or state-dependant pricing. The introduction of openeconomy factors into the new Keynesian Phillips curve complicate matters further as it must capture the nexus between price setting, inflation and the exchange rate. This is nevertheless a crucial feature for any model to be used for inflation...
Algebraic curves of maximal cyclicity
Caubergh, Magdalena; Dumortier, Freddy
2006-01-01
The paper deals with analytic families of planar vector fields, studying methods to detect the cyclicity of a non-isolated closed orbit, i.e. the maximum number of limit cycles that can locally bifurcate from it. It is known that this multi-parameter problem can be reduced to a single-parameter one, in the sense that there exist analytic curves in parameter space along which the maximal cyclicity can be attained. In that case one speaks about a maximal cyclicity curve (mcc) in case only the number is considered and of a maximal multiplicity curve (mmc) in case the multiplicity is also taken into account. In view of obtaining efficient algorithms for detecting the cyclicity, we investigate whether such mcc or mmc can be algebraic or even linear depending on certain general properties of the families or of their associated Bautin ideal. In any case by well chosen examples we show that prudence is appropriate.
Interactions of Cosmic Rays in the Atmosphere: Growth Curves Revisited
Obermeier, A; Hörandel, J; Müller, D
2013-01-01
Measurements of cosmic-ray abundances on balloons are affected by interactions in the residual atmosphere above the balloon. Corrections for such interactions are particularly important for observations of rare secondary particles such as boron, antiprotons and positrons. These corrections can either be calculated if the relevant cross sections in the atmosphere are known, or may be empirically determined by extrapolation of the "growth curves", i. e. the individual particle intensities as functions of atmospheric depth. The growth-curve technique is particularly attractive for long-duration balloon flights where the periodic daily altitude variations permit rather precise determinations of the corresponding particle intensity variations. We determine growth curves for nuclei from boron (Z=5) to iron (Z=26), using data from the 2006 Arctic balloon flight of the TRACER detector for cosmic-ray nuclei, and we compare the growth curves with predictions from published cross section values. In general, good agreeme...
Shock detachment from curved wedges
Mölder, S.
2017-03-01
Curved shock theory is used to show that the flow behind attached shocks on doubly curved wedges can have either positive or negative post-shock pressure gradients depending on the freestream Mach number, the wedge angle and the two wedge curvatures. Given enough wedge length, the flow near the leading edge can choke to force the shock to detach from the wedge. This local choking can preempt both the maximum deflection and the sonic criteria for shock detachment. Analytical predictions for detachment by local choking are supported by CFD results.
Shock detachment from curved wedges
Mölder, S.
2017-09-01
Curved shock theory is used to show that the flow behind attached shocks on doubly curved wedges can have either positive or negative post-shock pressure gradients depending on the freestream Mach number, the wedge angle and the two wedge curvatures. Given enough wedge length, the flow near the leading edge can choke to force the shock to detach from the wedge. This local choking can preempt both the maximum deflection and the sonic criteria for shock detachment. Analytical predictions for detachment by local choking are supported by CFD results.
Caloric Curves and Nuclear Expansion
Natowitz, J B; Ma, Y; Murray, M; Qin, L; Shlomo, S; Wada, R; Wang, J
2002-01-01
Nuclear caloric curves have been analyzed using an expanding Fermi gas hypothesis to extract average nuclear densities. In this approach the observed flattening of the caloric curves reflects progressively increasing expansion with increasing excitation energy. This expansion results in a corresponding decrease in the density and Fermi energy of the excited system. For nuclei of medium to heavy mass apparent densities $~0.3\\rho_0$ are reached at the higher excitation energies. The average densities derived in this manner are in good agreement with those derived using other, more complicated, techniques.
Curved branes with regular support
Antoniadis, Ignatios [Sorbonne Universites, LPTHE, UMR CNRS 7589, Paris (France); University of Bern, Albert Einstein Center for Fundamental Physics, ITP, Bern (Switzerland); Cotsakis, Spiros; Klaoudatou, Ifigeneia [American University of the Middle East, Department of Mathematics, P. O. Box 220, Dasman (Kuwait)
2016-09-15
We study spacetime singularities in a general five-dimensional braneworld with curved branes satisfying four-dimensional maximal symmetry. The bulk is supported by an analog of perfect fluid with the time replaced by the extra coordinate. We show that contrary to the existence of finite-distance singularities from the brane location in any solution with flat (Minkowski) branes, in the case of curved branes there are singularity-free solutions for a range of equations of state compatible with the null energy condition. (orig.)
Winfree, Arthur T.
1975-01-01
Reports on experiments conducted on two biological clocks, in organisms in the plant and animal kingdoms, which indicate that biological oscillation can be arrested by a single stimulus of a definite strength delivered at the proper time. (GS)
Winfree, Arthur T.
1975-01-01
Reports on experiments conducted on two biological clocks, in organisms in the plant and animal kingdoms, which indicate that biological oscillation can be arrested by a single stimulus of a definite strength delivered at the proper time. (GS)
曹昱澎; 惠虎; 轩福贞
2011-01-01
The size effect on master curve reference temperature for 16MnR was studied using 1 T - SE ( B) , 0. 5 T - SE( B) and PCVN specimens. It is found that the allowable limit of M specified in ASTM E1921 is un - conservative. Although To value from 0. 5 T - SE( B) is valid according to E1921, it is much lower than the 1 T - SE( B) result. However,the To from PCVN data is invalid. The fracture toughness data from 0.5 T and PCVN specimens were scaled to the 1 T size by using Beremin model. Taking account of the constraint effect, the difference between To values measured using small specimens and 1 T specimen is obviously decreased.%采用16MnR钢进行了标准1英寸,0.5英寸和预制裂纹的夏比尺寸三点弯试样的断裂韧性试验,得到了试样尺寸对主曲线参考温度T0的影响.发现0.5英寸试样在满足ASTM E1921标准的情况下,所确定的T0明显低于标准1英寸试样确定的T0,表明ASTM E1921限定试样变形极限的M值不够保守,且夏比尺寸试样无法计算T0.提出了Beremin模型的拘束度修正,经过修正大幅缩小了小尺寸试样确定的T0与1英寸试样确定的T0之间的差异.
Nacelle power curve measurement with spinner anemometer and uncertainty evaluation
Demurtas, Giorgio; Friis Pedersen, Troels; Wagner, Rozenn
2016-01-01
The objective of this investigation was to verify the feasibility of using the spinner anemometer calibration and nacelle transfer function determined on one reference turbine, to assess the power performance of a second identical turbine. An experiment was set up with a met-mast in a position...... suitable to measure the power curve of the two wind turbines, both equipped with a spinner anemometer. An IEC 61400-12-1 compliant power curve was then measured for both turbines using the met-mast. The NTF (Nacelle Transfer Function) was measured on the reference turbine and then applied to both turbines...... to calculate the free wind speed. For each of the two wind turbines, the power curve (PC) was measured with the met-mast and the nacelle power curve (NPC) with the spinner anemometer. Four power curves (two PC and two NPC) were compared in terms of AEP (Annual Energy Production) for a Rayleigh wind speed...
Review of dose-response curves for acute antimigraine drugs
Hougaard, Anders; Tfelt-Hansen, Peer
2015-01-01
INTRODUCTION: Dose-response curves for efficacy and tolerability are the important determinants for the choice of doses of acute migraine drugs. Areas covered: Dose-response curves for the efficacy of seven triptans (5-HT1B/1D receptor agonists), a 5-HT1F receptor agonist (lasmiditan) and four oral...... calcitonin-gene related peptide receptor antagonists (telcagepant, MK-3207, BI 44370 TA and BMS-927711) in placebo-controlled trials were reviewed. In addition, dose-response curves for adverse events (AEs) were reviewed. Expert opinion: For most triptans, the dose-response curve for efficacy is flat......, whereas AEs often increase with increasing doses. The two other groups of drugs also have flat dose-response curves for efficacy. Overall, the triptans still have the most favorable efficacy-tolerability profile. Current acute antimigraine drugs do not fulfill the expectations of the patients, and thus...
Jha, Pawan Kumar; Bouâouda, Hanan; Gourmelen, Sylviane; Dumont, Stephanie; Fuchs, Fanny; Goumon, Yannick; Bourgin, Patrice; Kalsbeek, Andries; Challet, Etienne
2017-04-19
Circadian rhythms in nocturnal and diurnal mammals are primarily synchronized to local time by the light/dark cycle. However, nonphotic factors, such as behavioral arousal and metabolic cues, can also phase shift the master clock in the suprachiasmatic nuclei (SCNs) and/or reduce the synchronizing effects of light in nocturnal rodents. In diurnal rodents, the role of arousal or insufficient sleep in these functions is still poorly understood. In the present study, diurnal Sudanian grass rats, Arvicanthis ansorgei, were aroused at night by sleep deprivation (gentle handling) or caffeine treatment that both prevented sleep. Phase shifts of locomotor activity were analyzed in grass rats transferred from a light/dark cycle to constant darkness and aroused in early night or late night. Early night, but not late night, sleep deprivation induced a significant phase shift. Caffeine on its own induced no phase shifts. Both sleep deprivation and caffeine treatment potentiated light-induced phase delays and phase advances in response to a 30 min light pulse, respectively. Sleep deprivation in early night, but not late night, potentiated light-induced c-Fos expression in the ventral SCN. Caffeine treatment in midnight triggered c-Fos expression in dorsal SCN. Both sleep deprivation and caffeine treatment potentiated light-induced c-Fos expression in calbindin-containing cells of the ventral SCN in early and late night. These findings indicate that, in contrast to nocturnal rodents, behavioral arousal induced either by sleep deprivation or caffeine during the sleeping period potentiates light resetting of the master circadian clock in diurnal rodents, and activation of calbindin-containing suprachiasmatic cells may be involved in this effect.SIGNIFICANCE STATEMENT Arousing stimuli have the ability to regulate circadian rhythms in mammals. Behavioral arousal in the sleeping period phase shifts the master clock in the suprachiasmatic nuclei and/or slows down the photic
Kandalepas, Patty C.; Mitchell, Jennifer W.; Gillette, Martha U.
2016-01-01
Melatonin is released from the pineal gland into the circulatory system at night in the absence of light, acting as “hormone of darkness” to the brain and body. Melatonin also can regulate circadian phasing of the suprachiasmatic nucleus (SCN). During the day-to-night transition, melatonin exposure advances intrinsic SCN neural activity rhythms via the melatonin type-2 (MT2) receptor and downstream activation of protein kinase C (PKC). The effects of melatonin on SCN phasing have not been linked to daily changes in the expression of core genes that constitute the molecular framework of the circadian clock. Using real-time RT-PCR, we found that melatonin induces an increase in the expression of two clock genes, Period 1 (Per1) and Period 2 (Per2). This effect occurs at CT 10, when melatonin advances SCN phase, but not at CT 6, when it does not. Using anti-sense oligodeoxynucleotides (α ODNs) to Per 1 and Per 2, as well as to E-box enhancer sequences in the promoters of these genes, we show that their specific induction is necessary for the phase-altering effects of melatonin on SCN neural activity rhythms in the rat. These effects of melatonin on Per1 and Per2 were mediated by PKC. This is unlike day-active non-photic signals that reset the SCN clock by non-PCK signal transduction mechanisms and by decreasing Per1 expression. Rather, this finding extends roles for Per1 and Per2, which are critical to photic phase-resetting, to a nonphotic zeitgeber, melatonin, and suggest that the regulation of these clock gene transcripts is required for clock resetting by diverse regulatory cues. PMID:27362940
Sergio Solinas
2007-12-01
Full Text Available The Golgi cells are inhibitory interneurons of the cerebellar granular layer, which respond to afferent stimulation in vivo with a burst-pause sequence interrupting their irregular background low-frequency firing (Vos et al., 1999a. Eur. J. Neurosci. 11, 2621–2634. However, Golgi cells in vitro are regular pacemakers (Forti et al., 2006. J. Physiol. 574, 711–729, raising the question how their ionic mechanisms could impact on responses during physiological activity. Using patch-clamp recordings in cerebellar slices we show that the pacemaker cycle can be suddenly reset by spikes, making the cell highly sensitive to input variations. Moreover, the neuron resonates around the pacemaker frequency, making it specifically sensitive to patterned stimulation in the theta-frequency band. Computational analysis based on a model developed to reproduce Golgi cell pacemaking (Solinas et al., 2008 Front. Neurosci., 1:2 predicted that phase-reset required spike-triggered activation of SK channels and that resonance was sustained by a slow voltage-dependent potassium current and amplified by a persistent sodium current. Adding balanced synaptic noise to mimic the irregular discharge observed in vivo, we found that pacemaking converts into spontaneous irregular discharge, that phase-reset plays an important role in generating the burst-pause pattern evoked by sensory stimulation, and that repetitive stimulation at theta-frequency enhances the time-precision of spike coding in the burst. These results suggest that Golgi cell intrinsic properties exert a profound impact on time-dependent signal processing in the cerebellar granular layer.
Solinas, Sergio; Forti, Lia; Cesana, Elisabetta; Mapelli, Jonathan; De Schutter, Erik; D'Angelo, Egidio
2007-01-01
The Golgi cells are inhibitory interneurons of the cerebellar granular layer, which respond to afferent stimulation in vivo with a burst-pause sequence interrupting their irregular background low-frequency firing (Vos et al., 1999a. Eur. J. Neurosci. 11, 2621-2634). However, Golgi cells in vitro are regular pacemakers (Forti et al., 2006. J. Physiol. 574, 711-729), raising the question how their ionic mechanisms could impact on responses during physiological activity. Using patch-clamp recordings in cerebellar slices we show that the pacemaker cycle can be suddenly reset by spikes, making the cell highly sensitive to input variations. Moreover, the neuron resonates around the pacemaker frequency, making it specifically sensitive to patterned stimulation in the theta-frequency band. Computational analysis based on a model developed to reproduce Golgi cell pacemaking (Solinas et al., 2008Front. Neurosci., 2:2) predicted that phase-reset required spike-triggered activation of SK channels and that resonance was sustained by a slow voltage-dependent potassium current and amplified by a persistent sodium current. Adding balanced synaptic noise to mimic the irregular discharge observed in vivo, we found that pacemaking converts into spontaneous irregular discharge, that phase-reset plays an important role in generating the burst-pause pattern evoked by sensory stimulation, and that repetitive stimulation at theta-frequency enhances the time-precision of spike coding in the burst. These results suggest that Golgi cell intrinsic properties exert a profound impact on time-dependent signal processing in the cerebellar granular layer.
Patty C Kandalepas
Full Text Available Melatonin is released from the pineal gland into the circulatory system at night in the absence of light, acting as "hormone of darkness" to the brain and body. Melatonin also can regulate circadian phasing of the suprachiasmatic nucleus (SCN. During the day-to-night transition, melatonin exposure advances intrinsic SCN neural activity rhythms via the melatonin type-2 (MT2 receptor and downstream activation of protein kinase C (PKC. The effects of melatonin on SCN phasing have not been linked to daily changes in the expression of core genes that constitute the molecular framework of the circadian clock. Using real-time RT-PCR, we found that melatonin induces an increase in the expression of two clock genes, Period 1 (Per1 and Period 2 (Per2. This effect occurs at CT 10, when melatonin advances SCN phase, but not at CT 6, when it does not. Using anti-sense oligodeoxynucleotides (α ODNs to Per 1 and Per 2, as well as to E-box enhancer sequences in the promoters of these genes, we show that their specific induction is necessary for the phase-altering effects of melatonin on SCN neural activity rhythms in the rat. These effects of melatonin on Per1 and Per2 were mediated by PKC. This is unlike day-active non-photic signals that reset the SCN clock by non-PCK signal transduction mechanisms and by decreasing Per1 expression. Rather, this finding extends roles for Per1 and Per2, which are critical to photic phase-resetting, to a nonphotic zeitgeber, melatonin, and suggest that the regulation of these clock gene transcripts is required for clock resetting by diverse regulatory cues.
Grand'homme, Alexis; Janots, Emilie; Seydoux-Guillaume, Anne-Magali; Guillaume, Damien; Bosse, Valérie; Magnin, Valérie
2016-04-01
Hydrothermal alteration experiments of natural monazite crystals (Manangotry, Madagascar; 555 Ma) under alkali conditions (NaOH 1M in 18O doped solution) at low temperature conditions (300, 400, 500 and 600°C), 200 MPa, were conducted to clarify the origin of unsupported Pb (radiogenic or not) in altered monazite (Seydoux-Guillaume et al., 2012). At 300°C, no evidence of monazite replacement was observed. From 400 to 600°C, experimental products show a replacement texture with pristine monazite (Mnz1) surrounded by an alteration rim with a different composition (SEM and EPMA). In the altered domains, in-situ isotopic and chemical U-Th-Pb dating yields intermediate ages between original monazite (555 Ma) and complete experimental resetting (0 Ma). Incomplete resetting is due to the systematic presence of Pb in altered domains, whose concentration decreases with increasing temperature. Transmission Electron Microscope (TEM) observations reveal an incomplete replacement of Mnz1 by a secondary monazite (Mnz2), free of Pb, within the altered domain. The latter domain, apparently homogeneous in BSE images, is in fact constituted by closely associated nano-mixtures of Mnz1 and Mnz2. Furthermore, the volume of Mnz2 within the altered domain, i.e. the efficiency of replacement, increases with increasing temperature. Apparent partial resetting of U-Th-Pb systems results from the unavoidable nano-mixture of different proportion of Mnz1 and Mnz2 within the analytical microvolume (EPMA, LA-ICP-MS). This study therefore indicates that the micrometric resolution (even the 5 μm3 for EPMA) of in-situ dating techniques may be not sufficient to solve such nano-replacement domains, especially when alteration occurs at low-temperature. Ref: Seydoux-Guillaume, A.-M., Montel, J.-M., Bingen, B., Bosse, V., de Parseval, P., Paquette, J.-L., Janots, E., and Wirth, R., (2012). Chemical Geology, v. 330-331, p. 140-158.
Principal Curves on Riemannian Manifolds.
Hauberg, Soren
2016-09-01
Euclidean statistics are often generalized to Riemannian manifolds by replacing straight-line interpolations with geodesic ones. While these Riemannian models are familiar-looking, they are restricted by the inflexibility of geodesics, and they rely on constructions which are optimal only in Euclidean domains. We consider extensions of Principal Component Analysis (PCA) to Riemannian manifolds. Classic Riemannian approaches seek a geodesic curve passing through the mean that optimizes a criteria of interest. The requirements that the solution both is geodesic and must pass through the mean tend to imply that the methods only work well when the manifold is mostly flat within the support of the generating distribution. We argue that instead of generalizing linear Euclidean models, it is more fruitful to generalize non-linear Euclidean models. Specifically, we extend the classic Principal Curves from Hastie & Stuetzle to data residing on a complete Riemannian manifold. We show that for elliptical distributions in the tangent of spaces of constant curvature, the standard principal geodesic is a principal curve. The proposed model is simple to compute and avoids many of the pitfalls of traditional geodesic approaches. We empirically demonstrate the effectiveness of the Riemannian principal curves on several manifolds and datasets.
Variability among polysulphone calibration curves
Casale, G R [University of Rome ' La Sapienza' , Physics Department, P.le A. Moro 2, I-00185, Rome (Italy); Borra, M [ISPESL - Istituto Superiore per la Prevenzione E la Sicurezza del Lavoro, Occupational Hygiene Department, Via Fontana Candida 1, I-0040 Monteporzio Catone (RM) (Italy); Colosimo, A [University of Rome ' La Sapienza' , Department of Human Physiology and Pharmacology, P.le A. Moro 2, I-00185, Rome (Italy); Colucci, M [ISPESL - Istituto Superiore per la Prevenzione E la Sicurezza del Lavoro, Occupational Hygiene Department, Via Fontana Candida 1, I-0040 Monteporzio Catone (RM) (Italy); Militello, A [ISPESL - Istituto Superiore per la Prevenzione E la Sicurezza del Lavoro, Occupational Hygiene Department, Via Fontana Candida 1, I-0040 Monteporzio Catone (RM) (Italy); Siani, A M [University of Rome ' La Sapienza' , Physics Department, P.le A. Moro 2, I-00185, Rome (Italy); Sisto, R [ISPESL - Istituto Superiore per la Prevenzione E la Sicurezza del Lavoro, Occupational Hygiene Department, Via Fontana Candida 1, I-0040 Monteporzio Catone (RM) (Italy)
2006-09-07
Within an epidemiological study regarding the correlation between skin pathologies and personal ultraviolet (UV) exposure due to solar radiation, 14 field campaigns using polysulphone (PS) dosemeters were carried out at three different Italian sites (urban, semi-rural and rural) in every season of the year. A polysulphone calibration curve for each field experiment was obtained by measuring the ambient UV dose under almost clear sky conditions and the corresponding change in the PS film absorbance, prior and post exposure. Ambient UV doses were measured by well-calibrated broad-band radiometers and by electronic dosemeters. The dose-response relation was represented by the typical best fit to a third-degree polynomial and it was parameterized by a coefficient multiplying a cubic polynomial function. It was observed that the fit curves differed from each other in the coefficient only. It was assessed that the multiplying coefficient was affected by the solar UV spectrum at the Earth's surface whilst the polynomial factor depended on the photoinduced reaction of the polysulphone film. The mismatch between the polysulphone spectral curve and the CIE erythemal action spectrum was responsible for the variability among polysulphone calibration curves. The variability of the coefficient was related to the total ozone amount and the solar zenith angle. A mathematical explanation of such a parameterization was also discussed.
Space curves, anholonomy and nonlinearity
Radha Balakrishnan
2005-04-01
Using classical differential geometry, we discuss the phenomenon of anholonomy that gets associated with a static and a moving curve. We obtain the expressions for the respective geometric phases in the two cases and interpret them. We show that there is a close connection between anholonomy and nonlinearity in a wide class of nonlinear systems.
The New Keynesian Phillips Curve
Ólafsson, Tjörvi
, learning or state-dependant pricing. The introduction of openeconomy factors into the new Keynesian Phillips curve complicate matters further as it must capture the nexus between price setting, inflation and the exchange rate. This is nevertheless a crucial feature for any model to be used for inflation...... forecasting in a small open economy like Iceland....
Murre, J.M.J.
2014-01-01
In this article, learning curves for foreign vocabulary words are investigated, distinguishing between a subject-specific learning rate and a material-specific parameter that is related to the complexity of the items, such as the number of syllables. Two experiments are described, one with Turkish w
ESTIMATING TORSION OF DIGITAL CURVES USING 3D IMAGE ANALYSIS
Christoph Blankenburg
2016-04-01
Full Text Available Curvature and torsion of three-dimensional curves are important quantities in fields like material science or biomedical engineering. Torsion has an exact definition in the continuous domain. However, in the discrete case most of the existing torsion evaluation methods lead to inaccurate values, especially for low resolution data. In this contribution we use the discrete points of space curves to determine the Fourier series coefficients which allow for representing the underlying continuous curve with Cesàro’s mean. This representation of the curve suits for the estimation of curvature and torsion values with their classical continuous definition. In comparison with the literature, one major advantage of this approach is that no a priori knowledge about the shape of the cyclic curve parts approximating the discrete curves is required. Synthetic data, i.e. curves with known curvature and torsion, are used to quantify the inherent algorithm accuracy for torsion and curvature estimation. The algorithm is also tested on tomographic data of fiber structures and open foams, where discrete curves are extracted from the pore spaces.
Conventional flow curves of liquid cast iron put on spheroidization
B. Borowiecki
2008-04-01
Full Text Available The purpose of the investigation was to confirm the hypothesis that the conventional flow curves of liquid cast iron put on sferoidization determined from the rod fluidity test are comparable to flow curves of liquids in environmental temperature. Moreover has been identified, that conventional flow curves for this liquid cast iron are similar to generalized non- Newtonian liquids curves.For rods with the diameters 3-8 mm there are three various curves:1 – the flow curve of liquid cast iron put on spheroidization overheated about 80 K resemble a shape adequately to a curve of densified liquid with shearing. This phenomenon can be caused by high overcooled and creation of crystallization nuclei;2 – metal alloys overheated about 180 K resemble a shape adequately to Newtonian liquid;3 – metal alloys overheated about 210 K resemble a shape of curve adequately to dispersed liquid with shearing. This phenomenon probably depends on influence of gas which creates on boundary of metal-sand mould.
谭延亮; 肖德涛; 赵桂芝; 周青芝; 单健; 康玺
2011-01-01
At present, the continuous radon monitor based on the electrostatic collection method has been widely used. The collection efficiency of the positively charged radon progeny in the electrostatic field of the measurement cell related to the OH- ions concentration of water vapor molecules. Using the analytical expression of e-quilibrium ion content of water vapor in air from literature, we obtain the analytic expression of 218Po collection efficiency related the temperature and humidity from kinetic theory. Thus, multiple measurements can be used to improve the accuracy of four parameters C, g,λand σ. The accuracy of the collection efficiency related the temperature and humidity curves can be improve and the experimental workload will be reduced. At the same time, a novel method for measuring the recombination probability of a positively charged 218Po and the OH "ion.%当前,基于静电收集法的连续测氡仪得到了广泛应用.静电场对带正电的氡子体的收集效率与测量室内空气中水蒸气分子电离的OH-离子浓度有关.从分子运动论出发,利用相关文献给出的空气中水蒸气的OH-离子浓度的解析表达式,得到了218Po收集效率的温、湿度曲线的解析表达式.这样就可以利用多次测量提高C、g、λ、σ这四个常数的精度,从而提高收集效率的温、湿度曲线的准确性,并且可以减少实验测量工作量.同时得到了一种带正电218Po与OH-离子复合概率的测量方法.
Atlas of Secular Light Curves of Comets
Ferrin, Ignacio
2007-12-01
We have completed work on the secular light curves of 30 periodic and non-periodic comets. The objectives and approach of this project has been explained in Ferrin (Icarus, 178, 493-516, 2005). Each comet requires 2 plots. The time plot shows the reduced (to Δ = 1 AU) magnitude of the comet as a function of time, thus displaying the brightness history of the object. The log plot is a reflected double log plot. The reflection takes place at R=1 AU, to allow the determination of the absolute magnitude by extrapolation. 22 photometric parameters are measured from the plots, most of them new. The plots have been collected in a document that constitutes "The Atlas". We have defined a photometric age, P-AGE, that attempts to measure the age of a comet based on its activity. P-AGE has been scaled to human ages to help in its interpretation. We find that comets Hale-Bopp and 29P/SW 1, are baby comets (P-AGE 100 cy). The secular light curve of 9P/Tempel 1 exhibits sublimation due to H2O and due to CO. Comet 67P/Churyumov-Gerasimento to be visited by the Rossetta spacecraft in 2014 exhibits a photometric anomaly. Comet 65P/Gunn exhibits a lag in maximum brightness of LAG = + 254 days after perihelion. We suggest that the pole is pointing to the sun at that time. The secular light curves will be presented and a preliminary interpretation will be advanced. The secular light curves present complexity beyond current understanding. The observations described in this work were carried out at the National Observatory of Venezuela (ONV), managed by the Center for Research in Astronomy (CIDA), for the Ministry of Science and Technology (MinCyT).
Task 4 Improvised Nuclear Device Response Curves
Alai, Maureen [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Neuscamman, Stephanie [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
2016-05-31
LLNL performed fallout and nuclear blast modeling for the 60 cities using the NARAC modeling system and predominant weather patterns determined in a previous Task 4 effort. LLNL performed model simulations and analyses to identify and provide response curves (expressed as two-dimensional contours) for radioactive fallout deposition, transport, population, and blast overpressure as a function of yield, weather, location and time. These contours can then be further combined and correlated with infrastructure and population databases to estimate city specific effects on KPFs such as impacted infrastructure and casualty rates.
The Milky Way rotation curve revisited
Russeil, D.; Zavagno, A.; Mège, P.; Poulin, Y.; Molinari, S.; Cambresy, L.
2017-05-01
The Herschel survey of the Galactic Plane (Hi-GAL) is a continuum Galactic plane survey in five wavebands at 70, 160, 250, 350 and 500 μm. From such images, about 150 000 sources have been extracted for which the distance determination is a challenge. In this context the velocity of these sources has been determined thanks to a large number of molecular data cubes. But to convert the velocity to kinematic distance, one needs to adopt a rotation curve for our Galaxy. For three different samples of tracers, we test different analytical forms. We find that the power-law expression, θ(R)/θ0 = 1.022 (R/R0)0.0803 with R0, θ0 = 8.34 kpc, 240 km s-1 is a good and easily manipulated expression for the distance determination process.
Real-Time Exponential Curve Fits Using Discrete Calculus
Rowe, Geoffrey
2010-01-01
An improved solution for curve fitting data to an exponential equation (y = Ae(exp Bt) + C) has been developed. This improvement is in four areas -- speed, stability, determinant processing time, and the removal of limits. The solution presented avoids iterative techniques and their stability errors by using three mathematical ideas: discrete calculus, a special relationship (be tween exponential curves and the Mean Value Theorem for Derivatives), and a simple linear curve fit algorithm. This method can also be applied to fitting data to the general power law equation y = Ax(exp B) + C and the general geometric growth equation y = Ak(exp Bt) + C.
The Algebraic Curve of 1-loop Planar N=4 SYM
Schafer-Nameki, S
2004-01-01
The algebraic curve for the psu (2,2|4) quantum spin chain is determined from the thermodynamic limit of the algebraic Bethe ansatz. The Hamiltonian of this spin chain has been identified with the planar 1-loop dilatation operator of N=4 SYM. In the dual AdS_5 x S^5 string theory, various properties of the data defining the curve for the gauge theory are compared to the ones obtained from semiclassical spinning-string configurations, in particular for the case of strings on AdS_5 x S^1 and the su(2,2) spin chain agreement of the curves is shown.
Unfired clay bricks – retention curves and liquid diffusivities
Hansen, Kurt Kielsgaard; Peuhkuri, Ruut Hannele; Kristensen, A.
2002-01-01
This paper presents retention curves and liquid diffusivities of two different types of unfired clay bricks, both produced in Denmark on commercial basis. The retention curves are determined by use of pressure plate and pressure membrane apparatuses. The liquid diffusivity is calculated on the ba...... on the basis of capillary rise of water measured by use of X-ray equipment. The data from the capillary rise of water is transformed by the Boltzmann transformation....
Nacelle power curve measurement with spinner anemometer and uncertainty evaluation
Demurtas, Giorgio; Friis Pedersen, Troels; Wagner, Rozenn
2017-01-01
The objective of this investigation was to verify the feasibility of using the spinner anemometer calibration and nacelle transfer function determined on one reference wind turbine, in order to assess the power performance of a second identical turbine. An experiment was set up with a met mast in a position suitable to measure the power curve of the two wind turbines, both equipped with a spinner anemometer. An IEC 61400-12-1-compliant power curve was then measured for both ...
Singular Fibers in Barking Families of Degenerations of Elliptic Curves
Okuda, Takayuki
2012-01-01
Takamura established a theory on splitting families of degenerations of complex curves. He introduced a powerful method for constructing a splitting family, called a barking family, in which there appear not only a singular fiber over the origin but also singular fibers over other points, called subordinate fibers. In this paper, for the case of degenerations of elliptic curves, we determine the types of these subordinate fibers.
Learning curve in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
Moradi, Bijan N; Esquivel, Jesus
2009-09-15
Cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy have achieved good long-term results in patients with complete surgical eradication of their peritoneal dissemination but at the expense of significant perioperative morbidity and mortality. The high complication rate has been attributed to the steep learning curve associated with this procedure. We report on the current literature regarding the learning curve for this procedure and the key components that determine the success in learning this new skill.
A catalog of special plane curves
Lawrence, J Dennis
2014-01-01
Among the largest, finest collections available-illustrated not only once for each curve, but also for various values of any parameters present. Covers general properties of curves and types of derived curves. Curves illustrated by a CalComp digital incremental plotter. 12 illustrations.
Attempt to approach geological interpretation using integrate well-logging curve analysis method
Yalin, F.
1988-01-01
In recent years, people widely use various well-logging curves to determine geological horizon, lithology, hydrocarbon content, etc. and have reaped some effects. The integrate well-logging curve analysis method described here adopts five types of well-logging curves: microlog curve, resistivity-logging curve, induced-current-log curve, spontaneous-potential curve and sonic-logging curve, which are used to form ''ladder diagram'' and ''spider diagram'' for the analysis. Logging curves taken from some wells in west Baxian depression are used to discuss how they analyse lithology and hydrocarbon content of formation. This method favors the comprehensive interpretation of anticline and lithology.
Principal Curves on Riemannian Manifolds
Hauberg, Søren
2015-01-01
Euclidean statistics are often generalized to Riemannian manifolds by replacing straight-line interpolations with geodesic ones. While these Riemannian models are familiar-looking, they are restricted by the inflexibility of geodesics, and they rely on constructions which are optimal only...... in Euclidean domains. We consider extensions of Principal Component Analysis (PCA) to Riemannian manifolds. Classic Riemannian approaches seek a geodesic curve passing through the mean that optimize a criteria of interest. The requirements that the solution both is geodesic and must pass through the mean tend...... from Hastie & Stuetzle to data residing on a complete Riemannian manifold. We show that for elliptical distributions in the tangent of spaces of constant curvature, the standard principal geodesic is a principal curve. The proposed model is simple to compute and avoids many of the pitfalls...
Invariance for Single Curved Manifold
Castro, Pedro Machado Manhaes de
2012-08-01
Recently, it has been shown that, for Lambert illumination model, solely scenes composed by developable objects with a very particular albedo distribution produce an (2D) image with isolines that are (almost) invariant to light direction change. In this work, we provide and investigate a more general framework, and we show that, in general, the requirement for such in variances is quite strong, and is related to the differential geometry of the objects. More precisely, it is proved that single curved manifolds, i.e., manifolds such that at each point there is at most one principal curvature direction, produce invariant is surfaces for a certain relevant family of energy functions. In the three-dimensional case, the associated energy function corresponds to the classical Lambert illumination model with albedo. This result is also extended for finite-dimensional scenes composed by single curved objects. © 2012 IEEE.
Optical conductivity of curved graphene.
Chaves, A J; Frederico, T; Oliveira, O; de Paula, W; Santos, M C
2014-05-07
We compute the optical conductivity for an out-of-plane deformation in graphene using an approach based on solutions of the Dirac equation in curved space. Different examples of periodic deformations along one direction translates into an enhancement of the optical conductivity peaks in the region of the far- and mid-infrared frequencies for periodicities ∼100 nm. The width and position of the peaks can be changed by dialling the parameters of the deformation profiles. The enhancement of the optical conductivity is due to intraband transitions and the translational invariance breaking in the geometrically deformed background. Furthermore, we derive an analytical solution of the Dirac equation in a curved space for a general deformation along one spatial direction. For this class of geometries, it is shown that curvature induces an extra phase in the electron wave function, which can also be explored to produce interference devices of the Aharonov-Bohm type.
Curved canals: Ancestral files revisited
Jain Nidhi
2008-01-01
Full Text Available The aim of this article is to provide an insight into different techniques of cleaning and shaping of curved root canals with hand instruments. Although a plethora of root canal instruments like ProFile, ProTaper, LightSpeed ® etc dominate the current scenario, the inexpensive conventional root canal hand files such as K-files and flexible files can be used to get optimum results when handled meticulously. Special emphasis has been put on the modifications in biomechanical canal preparation in a variety of curved canal cases. This article compiles a series of clinical cases of root canals with curvatures in the middle and apical third and with S-shaped curvatures that were successfully completed by employing only conventional root canal hand instruments.
A Study of Hyperelliptic Curves in Cryptography
Reza Alimoradi
2016-08-01
Full Text Available Elliptic curves are some specific type of curves known as hyper elliptic curves. Compared to the integer factorization problem(IFP based systems, using elliptic curve based cryptography will significantly decrease key size of the encryption. Therefore, application of this type of cryptography in systems that need high security and smaller key size has found great attention. Hyperelliptic curves help to make key length shorter. Many investigations are done with regard to improving computations, hardware and software implementation of these curves, their security and resistance against attacks. This paper studies and analyzes researches done about security and efficiency of hyperelliptic curves.
1992-12-16
12 = (K,, + )- (29) K 2 (see [3]). The parameter KM represents the amplitude of the periodic curva - ture function and sm denotes the value at which K...Additamentum De curvis elasticis. Methodus Inveniendi Lineas Curvas Maximi Minimive Proprietate Gaudentes, Ser. 1., Vol. 24, Lausanne 1744. 17 [10...Mathematical Theory of Elasticity. 4th. ed., Cambridge University Press, 1927. [12] G. Nielson. Bernstein/ Bezier Curves and Splines on Spheres based upon
Accelerating Around an Unbanked Curve
Mungan, Carl E.
2006-02-01
The December 2004 issue of TPT presented a problem concerning how a car should accelerate around an unbanked curve of constant radius r starting from rest if it is to avoid skidding. Interestingly enough, two solutions were proffered by readers.2 The purpose of this note is to compare and contrast the two approaches. Further experimental investigation of various turning strategies using a remote-controlled car and overhead video analysis could make for an interesting student project.
Reinsurance for Reset Guarantee in the Sparre Andersen Model%Sparre Andersen风险模型中的重置保证再保险
谭激扬; 邓丽; 杨向群
2013-01-01
We consider the Sparre Andersen risk model with a horizontal dividend barrier,and propose a new sort of reinsurance with reinsurance premiums extracted from the dividends in order to reset the surplus to a non-negative level when small deficits occur.We find that the reset guarantee reinsurance can not only remarkably enhance the discounted dividend amount prior to ruin,but also increase the average life of an insurance company.This advantage is proven,and numerical illustrations are given for an Erlang(2) risk model and a compound Poisson risk model.%考虑一个具有常数红利边界的Sparre-Andersen风险模型,在此模型中提出一种新的再保险以保证在公司出现较小的赤字时 再保险公司出资重置盈余到某个非负的水平,其中再保费从红利中提取.发现这样的重置保证再保险不但能显著提高破产前的贴现 红利总量,而且能提高公司的平均寿命.对如此的优势作者作了严格的数学证明,并且举了两个实例印证了结论.
Yang, P., E-mail: yangping0710@126.com [Central China Normal University, Wuhan (China); Aglieri, G.; Cavicchioli, C. [CERN, 1210 Geneva 23 (Switzerland); Chalmet, P.L. [MIND, Archamps (France); Chanlek, N. [Suranaree University of Technology, Nakhon Ratchasima (Thailand); Collu, A. [University of Cagliari, Cagliari (Italy); INFN (Italy); Gao, C. [Central China Normal University, Wuhan (China); Hillemanns, H.; Junique, A. [CERN, 1210 Geneva 23 (Switzerland); Kofarago, M. [CERN, 1210 Geneva 23 (Switzerland); University of Utrecht, Utrecht (Netherlands); Keil, M.; Kugathasan, T. [CERN, 1210 Geneva 23 (Switzerland); Kim, D. [Dongguk and Yonsei University, Seoul (Korea, Republic of); Kim, J. [Pusan National University, Busan (Korea, Republic of); Lattuca, A. [University of Torino, Torino (Italy); INFN (Italy); Marin Tobon, C.A. [CERN, 1210 Geneva 23 (Switzerland); Marras, D. [University of Cagliari, Cagliari (Italy); INFN (Italy); Mager, M.; Martinengo, P. [CERN, 1210 Geneva 23 (Switzerland); Mazza, G. [University of Torino, Torino (Italy); INFN (Italy); and others
2015-06-11
Active Pixel Sensors used in High Energy Particle Physics require low power consumption to reduce the detector material budget, low integration time to reduce the possibilities of pile-up and fast readout to improve the detector data capability. To satisfy these requirements, a novel Address-Encoder and Reset-Decoder (AERD) asynchronous circuit for a fast readout of a pixel matrix has been developed. The AERD data-driven readout architecture operates the address encoding and reset decoding based on an arbitration tree, and allows us to readout only the hit pixels. Compared to the traditional readout structure of the rolling shutter scheme in Monolithic Active Pixel Sensors (MAPS), AERD can achieve a low readout time and a low power consumption especially for low hit occupancies. The readout is controlled at the chip periphery with a signal synchronous with the clock, allows a good digital and analogue signal separation in the matrix and a reduction of the power consumption. The AERD circuit has been implemented in the TowerJazz 180 nm CMOS Imaging Sensor (CIS) process with full complementary CMOS logic in the pixel. It works at 10 MHz with a matrix height of 15 mm. The energy consumed to read out one pixel is around 72 pJ. A scheme to boost the readout speed to 40 MHz is also discussed. The sensor chip equipped with AERD has been produced and characterised. Test results including electrical beam measurement are presented.
Kass, David A.; Kitzman, Dalane W.; Alvarez, Guy E.
2009-01-01
Background Heart failure with preserved ejection fraction (HFpEF) is the predominant form of HF among the elderly and in women. However, there are few if any evidence-based therapeutic options for HFpEF. The chief complaint of HFpEF is reduced tolerance to physical exertion. Recent data revealed that one potential mechanism of exertional intolerance in HFpEF patients is inadequate chronotropic response. Although there is considerable evidence demonstrating the benefits of rate-adaptive pacing (RAP) provided from implantable cardiac devices in patients with an impaired chronotropic response, the effect of RAP in HFpEF is unknown. Methods and Results The RESET study is a prospective, multi-center, double-blind, randomized with stratification, study assessing the effect of RAP on peak VO2 and quality of life. RAP therapy will be evaluated in a cross-over paired fashion for each patient within each study stratum. Study strata are based on patient beta-blocker usage at time of enrollment. The study is powered to assess the impact of pacing independently in both strata. Conclusions The RESET study seeks to evaluate the potential benefit of RAP in patients with symptomatic mild to moderate HFpEF and chronotropic impairment. Study enrollment began in July 2008. PMID:20123314
Macdonald formula for curves with planar singularities
Maulik, Davesh
2011-01-01
We generalize Macdonald's formula for the cohomology of Hilbert schemes of points on a curve from smooth curves to curves with planar singularities: we relate the cohomology of the Hilbert schemes to the cohomology of the compactified Jacobian of the curve. The new formula is a consequence of a stronger identity between certain perverse sheaves defined by a family of curves satisfying mild conditions, whose proof makes an essential use of Ng\\^o's support theorem for compactified Jacobians.
Progress Report on Alloy 617 Isochronous Stress-Strain Curves
Jill K. Wright; Richard N. Wright; Nancy J. Lybeck
2014-03-01
Isochronous stress-strain curves for Alloy 617 up to a temperature of 1000°C will be required to qualify the material for elevated temperature design in Section III, Division 1, Subsection NH of the ASME Boiler and Pressure Vessel Code. Several potential methods for developing these curves are reviewed in this report. It is shown that in general power-law creep is the rate controlling deformation mechanism for a wide range of alloy heats, test temperatures and stresses. Measurement of the strain rate sensitivity of Alloy 617 indicates that the material is highly strain rate sensitive in the tensile deformation range above about 750°C. This suggests that the concept of a hot tensile curve as a bounding case on the isochronous stress-strain diagrams is problematic. The impact of strain rate on the hot tensile curves is examined and it is concluded that incorporating such a curve is only meaningful if a single tensile strain rate (typically the ASTM standard rate of 0.5%/min) is arbitrarily defined. Current experimentally determined creep data are compared to isochronous stress-strain curves proposed previously by the German programs in the 1980s and by the 1990 draft ASME Code Case. Variability in how well the experimental data are represented by the proposed design curves that suggests further analysis is necessary prior to completing a new draft Code Case.
Adaptive zero-tree structure for curved wavelet image coding
Zhang, Liang; Wang, Demin; Vincent, André
2006-02-01
We investigate the issue of efficient data organization and representation of the curved wavelet coefficients [curved wavelet transform (WT)]. We present an adaptive zero-tree structure that exploits the cross-subband similarity of the curved wavelet transform. In the embedded zero-tree wavelet (EZW) and the set partitioning in hierarchical trees (SPIHT), the parent-child relationship is defined in such a way that a parent has four children, restricted to a square of 2×2 pixels, the parent-child relationship in the adaptive zero-tree structure varies according to the curves along which the curved WT is performed. Five child patterns were determined based on different combinations of curve orientation. A new image coder was then developed based on this adaptive zero-tree structure and the set-partitioning technique. Experimental results using synthetic and natural images showed the effectiveness of the proposed adaptive zero-tree structure for encoding of the curved wavelet coefficients. The coding gain of the proposed coder can be up to 1.2 dB in terms of peak SNR (PSNR) compared to the SPIHT coder. Subjective evaluation shows that the proposed coder preserves lines and edges better than the SPIHT coder.
Estor Gnoatto
2005-07-01
Full Text Available No presente trabalho foi desenvolvido um estudo sobre um sistemafotovoltaico autônomo, com armazenamento de energia, instalado na Estação Experimental Agrometeorológica da Universidade Estadual do Oeste do Paraná, Estado do Paraná, Campus Cascavel, a uma latitude 24º 59’ Sul, longitude de 53º 26’ Oeste, com altitude de 682 metros, sob condições reais de campo, durante o ano de 2002. Foi determinada a curva característica do painel, utilizando uma aquisição de dados um "micrologger" da Campbell Scientific-INC modelo CR10X, programado para realizar uma leitura por segundo de cada canal e armazenar a média aritmética de cinco minutos dos dados das componentes detemperatura de operação do painel; tensão e corrente do sistema fotovoltaico. Baseando-se nesses dados pode-se determinar que a curva característica do painel em condições reais de campo apresenta uma perda de 24% em seu rendimento em relação ao padrão STC (condições padrão de teste.The purpose of the present work was to develop the study of anautonomous photovoltaic system, with storage of energy, installed in the Agrometeorological Experimental Station of Universidade Estadual do Oeste do Paraná, State of Paraná, Campus Cascavel, at 24º 59’ latitude south, 53º26 longitude west, 682 meters of altitude, under real field conditions, during the year 2002. Efficacy of the photovoltaic panels has been evaluated under real field conditions, as well as to determine its characteristic linear fit. A 'micrologger' Campbell Scientific-INC model CR10X was used to acquire data, and it was programmed to accomplish a reading per second in each channel and to store the arithmetic average of data from five minutes of operational temperature of the panel, photovoltaic system tension and current. According to results, it could determined that the panel characteristic linear fit in real field conditions shows 24% less field than standard STC (Standard Test Conditions.
Oil exploitation and the environmental Kuznets curve
Esmaeili, Abdoulkarim; Abdollahzadeh, Negar [Department of Agricultural Economics, College of Agriculture, Shiraz University, Shiraz, Fars (Iran)
2009-01-15
This study refers to a panel estimation of an environmental Kuznets curve (EKC) for oil to determine the factors most affecting oil exploitation in 38 oil-producing countries during 1990-2000. Control variables such as oil reserves, oil price, population, political rights, and the Gini index were used to determine its contribution to the main EKC model. The empirical results fully support the existence of an EKC for oil exploitation. Furthermore, the result indicates that the proved oil reserves has a significant and positive role in oil production, but oil price and population do not significantly affect crude oil production. Also, increased freedoms and a better income distribution will reduce the rate of oil exploitation. Thus, policies aiming at enhancing democratic society and better income distribution would be more compatible with sustainability. (author)
Bravim, Amanda
2015-07-01
The Volumetric Modulated Arc Therapy (VMAT) is an advance technique of Intensity Modulated Radiation Therapy (IMRT). This progress is due to the continuous gantry rotation with the radiation beam modulation providing lower time of the patient treatment. This research aimed the verification of the isodose curves in a simulation of a vertebra treatment with spinal cord protection using the thermoluminescent (TL) and optically stimulated luminescence (OSL) dosimetry techniques and the LiF:Mg,Ti (TLD-100), CaS0{sub 4}:Dy and Al{sub 2}0{sub 3}:C dosimeters and LiF:Mg,Ti micro dosimeters (TLD-100). The dosimeters were characterized using PMMA plates of 30 x 30 x 30 cm{sup 3} and different thickness. All irradiations were done using Truebeam STx linear accelerator of Hospital Israelita Albert Einstein, with 6 MV photons beam. After the dosimeter characterization, they were irradiated according the specific planning simulation and using a PMMA phantom developed to VMAT measurements. This irradiation aimed to verify the isodose curves of the treatment simulation using the two dosimetry techniques. All types of dosimeters showed satisfactory results to determine the dose distribution but analysing the complexity of the isodose curves and the proximity of them, the LiF:Mg,Ti micro dosimeter showed the most appropriate for use due to its small dimensions. Regarding the best technique, as both technique showed satisfactory results, the TL technique presents less complex to be used because the most of the radiotherapy departments already have a TL laboratory. The OSL technique requires more care and greater investment in the hospital. (author)
Numerical computation of fragility curves for NPP equipment
Zentner, I., E-mail: irmela.zentner@edf.f [LaMSID, Laboratory for the Mechanics of Aging Industrial Structures, UMR EDF/CNRS, 1, av. du General de Gaulle, 92141 Clamart (France)
2010-06-15
The seismic probabilistic risk assessment (PRA) methodology is a popular approach for evaluating the risk of failure of engineering structures due to earthquake. In this framework, fragility curves express the conditional probability of failure of a structure or component for a given seismic input motion parameter A, such as peak ground acceleration (PGA) or spectral acceleration. The failure probability due to a seismic event is obtained by convolution of fragility curves with seismic hazard curves. In general, a log-normal model is used in order to estimate fragilities. In nuclear engineering practice, these fragilities are determined using safety factors with respect to design earthquake. This approach allows to determine fragility curves based on design study but largely draws on expert judgement and simplifying assumptions. When a more realistic assessment of seismic fragility is needed, simulation-based statistical estimation of fragility curves is more appropriate. In this paper, we will discuss statistical estimation of parameters of fragility curves and present results obtained for a reactor coolant system of nuclear power plant. We have performed non-linear dynamic response analyses using artificially generated strong motion time histories. Uncertainties due to seismic loads as well as model uncertainties are taken into account and propagated using Monte Carlo simulation.
LINS Curve in Romanian Economy
Emilian Dobrescu
2016-02-01
Full Text Available The paper presents theoretical considerations and empirical evidence to test the validity of the Laffer in Narrower Sense (LINS curve as a parabola with a maximum. Attention is focused on the so-called legal-effective tax gap (letg. The econometric application is based on statistical data (1990-2013 for Romania as an emerging European economy. Three cointegrating regressions (fully modified least squares, canonical cointegrating regression and dynamic least squares and three algorithms, which are based on instrumental variables (two-stage least squares, generalized method of moments, and limited information maximum likelihood, are involved.
Principal -bundles on Nodal Curves
Usha N Bhosle
2001-08-01
Let be a connected semisimple affine algebraic group defined over . We study the relation between stable, semistable -bundles on a nodal curve and representations of the fundamental group of . This study is done by extending the notion of (generalized) parabolic vector bundles to principal -bundles on the desingularization of and using the correspondence between them and principal -bundles on . We give an isomorphism of the stack of generalized parabolic bundles on with a quotient stack associated to loop groups. We show that if is simple and simply connected then the Picard group of the stack of principal -bundles on is isomorphic to ⊕ , being the number of components of .
Sound propagation over curved barriers
Pierce, Allan D.; Main, Geoffrey L.; Kearns, James A.; Hsieh, H.-A.
1986-01-01
Wide barriers with curved tops are studied with emphasis placed on circumstances whereby the local radius of curvature R of the barrier is continuous along the surface and is large compared to a wavelength. Results analogous to those given by Hayek et al. (1978) are reviewed and extended to cases where the radius of curvature and the surface impedance may vary with position. Circumstances not easily interpreted within the framework of the model proposed by Keller (1956) and Hayek et al. are also considered.
Reconfigurable Double-Curved Mould
Raun, Christian; Kirkegaard, Poul Henning
2012-01-01
. This happens fast, automatic and without production of waste, and the manipulated surface is fair and robust, eliminating the need for additional, manual treatment. Limitations to the possibilities of the flexible form are limited curvature and limited level of detail, making it especially suited for larger......, double curved surfaces like facades or walls, where the curvature of each element is relatively small in comparison to the overall shape. In the proposed dynamic mould system, where only a set of points is defined, a stiff membrane interpolates the surface between points. To function as a surface...
Membranes Wrapped on Holomorphic Curves
Gauntlett, J P; Pakis, S; Waldram, D; Gauntlett, Jerome P.; Kim, Nakwoo; Pakis, Stathis; Waldram, Daniel
2002-01-01
We construct supergravity solutions dual to the twisted field theories arising when M-theory membranes wrap holomorphic curves in Calabi-Yau n-folds. The solutions are constructed in an Abelian truncation of maximal D=4 gauged supergravity and then uplifted to D=11. For four-folds and five-folds we find new smooth AdS/CFT examples and for all cases we analyse the nature of the singularities that arise. Our results provide an interpretation of certain charged topological AdS black holes. We also present the generalised calibration two-forms for the solutions.
Inferring asymmetric limb cloudiness on exoplanets from transit light curves
von Paris, P; Bordé, P; Leconte, J; Selsis, F
2016-01-01
Clouds have been shown to be present in many exoplanetary atmospheres. Cloud formation modeling predicts considerable inhomogeneities of cloud cover, consistent with optical phase curve observations. However, optical phase curves cannot resolve some existing degeneracies between cloud location and cloud optical properties. We present a conceptually simple technique to detect inhomogeneous cloud cover on exoplanets. Such an inhomogeneous cloud cover produces an asymmetric primary transit of the planet in front of the host star. Asymmetric transits produce characteristic residuals compared to a standard symmetric model. Furthermore, bisector spans can be used to determine asymmetries in the transit light curve. We apply a model of asymmetric transits to the light curves of HAT-P-7b, Kepler-7b and HD209458b and search for possible cloud signatures. The nearly uninterrupted Kepler photometry is particularly well-suited for this method since it allows for a very high time resolution. We do not find any statistical...
Determination of acid number in oils by standard curve method with green solvents%绿色溶剂—标准曲线法测定油品酸值
陆克平
2013-01-01
提出了一种直接pH测定油品酸值的免滴定方法.这种方法基于水/醇为主体的溶剂,内含有机碱性试剂,能4mim内完全萃取油品中酸性物质,用pH复合电极直接测定油品酸值.溶剂组成为体积比1:1的异丙醇和水,内含0.05～0.20mol/L的N-甲基二乙醇胺(MDEA)和0.02mol/L硝酸钾,预调至pH 11.30±0.05.确定了标准曲线区间,可测定0.007 mg KOH/g以上油品酸值.本方法耗时少,操作简便,具有不使用有毒试剂,室温下萃取与检测以及无需空白试验的特点,已在日常分析中应用,结果令人满意.%A direct pH-metric method for determination of acid number in some petroleum oils has been developed, based on water-isopropanol solvents with organic alkaline reagent. In just 4 min, it is able to completely and rapidly extract the sum of acids from an oil test portion into the special reagent in the iso-propanol-water phase by combination glass pH electrode measurement without titration. The reagent consisting of N-Methyldiethanolamine(MDEA) and potassium nitrate(KNOs) dissolved in water(H2O) and isopropanol (2-PrOH)with the initial conditional pH 11. 30±0. 05 [0. 05-0. 20 mol/L MDEA and 0. 02 mol/L KNO3 in the mixture of 50 % H2 O + 50 % 2-PrOH]. The limit of quantitation was 0. 007 mg(KOH)/g. The advantages of the method include absence of toxic solvents, extraction and inspection of acid number at room temperature, and no need for preliminary neutralization of acid admixtures in a solvent.
Differential geometry and topology of curves
Animov, Yu
2001-01-01
Differential geometry is an actively developing area of modern mathematics. This volume presents a classical approach to the general topics of the geometry of curves, including the theory of curves in n-dimensional Euclidean space. The author investigates problems for special classes of curves and gives the working method used to obtain the conditions for closed polygonal curves. The proof of the Bakel-Werner theorem in conditions of boundedness for curves with periodic curvature and torsion is also presented. This volume also highlights the contributions made by great geometers. past and present, to differential geometry and the topology of curves.
Smarandache Curves in Minkowski Space-time
Turgut, Melih; Yilmaz, Suha
2008-01-01
A regular curve in Minkowski space-time, whose position vector is composed by Frenet frame vectors on another regular curve, is called a Smarandache Curve. In this paper, we define a special case of such curves and call it Smarandache TB2 Curves in the space E41. Moreover, we compute formulas of its Frenet apparatus according to base curve via the method expressed in [3]. By this way, we obtain an another orthonormal frame of E41.
Light Curve Analysis of Neon Novae
Hachisu, Izumi
2015-01-01
We analyzed light curves of five neon novae, QU Vul, V351 Pup, V382 Vel, V693 CrA, and V1974 Cyg, and determined their white dwarf (WD) masses and distance moduli on the basis of theoretical light curves composed of free-free and photospheric emission. For QU Vul, we obtained a distance of d~2.4 kpc, reddening of E(B-V)~0.55, and WD mass of M_WD=0.82-0.96 M_sun. This suggests that an oxygen-neon WD lost a mass of more than ~0.1 M_sun since its birth. For V351 Pup, we obtained d~5.5 kpc, E(B-V)~0.45, and M_WD=0.98-1.1 M_sun. For V382 Vel, we obtained d~1.6 kpc, E(B-V)~0.15, and M_WD=1.13-1.28 M_sun. For V693 CrA, we obtained d~7.1 kpc, E(B-V)~0.05, and M_WD=1.15-1.25 M_sun. For V1974 Cyg, we obtained d~1.8 kpc, E(B-V)~0.30, and M_WD=0.95-1.1 M_sun. For comparison, we added the carbon-oxygen nova V1668 Cyg to our analysis and obtained d~5.4 kpc, E(B-V)~0.30, and M_WD=0.98-1.1 M_sun. In QU Vul, photospheric emission contributes 0.4-0.8 mag at most to the optical light curve compared with free-free emission only....
翟晚枫; 张春水; 高利生
2012-01-01
依据JJF 1059-1999《测量不确定度评定与表示》,以检测大麻树脂中四氢大麻酚含量的实验为例,评定了采用高效液相色谱外标工作曲线法进行含量测定的不确定度.建立了高效色谱外标工作曲线法测定样品含量的数学模型,分析了不确定度的来源并给出了量化结果,合成扩展不确定度为0.15％(k=2).%The determination uncertainty of tetrahydrocannabinol in cannabis resin by HPLC external standard working curve method was evaluated based on JJF 1059?999 Evaluation and Expression of Uncertainty in Measurement. The mathematical models to evaluate the uncertainty of quantitative results of HPLC external standard working curve method were established, and each source and uncertainty component was analysized, and the combined expanded uncertainty was 0.15%(k=2).
Flow characteristics of curved ducts
Rudolf P.
2007-10-01
Full Text Available Curved channels are very often present in real hydraulic systems, e.g. curved diffusers of hydraulic turbines, S-shaped bulb turbines, fittings, etc. Curvature brings change of velocity profile, generation of vortices and production of hydraulic losses. Flow simulation using CFD techniques were performed to understand these phenomena. Cases ranging from single elbow to coupled elbows in shapes of U, S and spatial right angle position with circular cross-section were modeled for Re = 60000. Spatial development of the flow was studied and consequently it was deduced that minor losses are connected with the transformation of pressure energy into kinetic energy and vice versa. This transformation is a dissipative process and is reflected in the amount of the energy irreversibly lost. Least loss coefficient is connected with flow in U-shape elbows, biggest one with flow in Sshape elbows. Finally, the extent of the flow domain influenced by presence of curvature was examined. This isimportant for proper placement of mano- and flowmeters during experimental tests. Simulations were verified with experimental results presented in literature.
Capacity theory on algebraic curves
Rumely, Robert S
1989-01-01
Capacity is a measure of size for sets, with diverse applications in potential theory, probability and number theory. This book lays foundations for a theory of capacity for adelic sets on algebraic curves. Its main result is an arithmetic one, a generalization of a theorem of Fekete and Szegö which gives a sharp existence/finiteness criterion for algebraic points whose conjugates lie near a specified set on a curve. The book brings out a deep connection between the classical Green's functions of analysis and Néron's local height pairings; it also points to an interpretation of capacity as a kind of intersection index in the framework of Arakelov Theory. It is a research monograph and will primarily be of interest to number theorists and algebraic geometers; because of applications of the theory, it may also be of interest to logicians. The theory presented generalizes one due to David Cantor for the projective line. As with most adelic theories, it has a local and a global part. Let /K be a smooth, complet...
Miniature curved artificial compound eyes.
Floreano, Dario; Pericet-Camara, Ramon; Viollet, Stéphane; Ruffier, Franck; Brückner, Andreas; Leitel, Robert; Buss, Wolfgang; Menouni, Mohsine; Expert, Fabien; Juston, Raphaël; Dobrzynski, Michal Karol; L'Eplattenier, Geraud; Recktenwald, Fabian; Mallot, Hanspeter A; Franceschini, Nicolas
2013-06-04
In most animal species, vision is mediated by compound eyes, which offer lower resolution than vertebrate single-lens eyes, but significantly larger fields of view with negligible distortion and spherical aberration, as well as high temporal resolution in a tiny package. Compound eyes are ideally suited for fast panoramic motion perception. Engineering a miniature artificial compound eye is challenging because it requires accurate alignment of photoreceptive and optical components on a curved surface. Here, we describe a unique design method for biomimetic compound eyes featuring a panoramic, undistorted field of view in a very thin package. The design consists of three planar layers of separately produced arrays, namely, a microlens array, a neuromorphic photodetector array, and a flexible printed circuit board that are stacked, cut, and curved to produce a mechanically flexible imager. Following this method, we have prototyped and characterized an artificial compound eye bearing a hemispherical field of view with embedded and programmable low-power signal processing, high temporal resolution, and local adaptation to illumination. The prototyped artificial compound eye possesses several characteristics similar to the eye of the fruit fly Drosophila and other arthropod species. This design method opens up additional vistas for a broad range of applications in which wide field motion detection is at a premium, such as collision-free navigation of terrestrial and aerospace vehicles, and for the experimental testing of insect vision theories.
Curve Length Estimation using Vertix Chain Code Curve Length Estimation
Habibollah Haron
2010-09-01
Full Text Available Most of the applications in image analysis are based on Freeman chain code. In this paper, for the first time, vertex chain code (VCC proposed by Bribiesca is applied to improve length estimation of the 2D digitized curve. The chain code has some preferences such as stable in shifting, turning, mirroring movement of image and has normalized starting point. Due to the variety of length estimator methods, we focused on the three specific techniques. First, the way Bribiesca proposed which is based on counting links between vertices; second, based on maximum length digital straight segments (DSSs and lastly local metrics. The results of these length estimators with the real perimeter are compared. Results thus obtained exhibits thatlength estimation using VCC is nearest to the actual length.
景天虎; 李桅; 李青宁; 张品乐
2011-01-01
以悬索桥主缆线形确定的常用精确数值解析算法为研究对象,通过对它们的比较分析和公式推导发现:在主缆理想柔性、忽略泊松比效应的最基本假定下,主缆线形确定的精确数值解析法可归结为主缆自重集度按其有、无应力长度计算作为已知条件的两大类算法；并且证明了在每大类解析算法中的所有方法是完全等价的.研究还表明:第二类解析算法为“全精确解析算法”,第一类为“准精确解析算法”；在第一类算法中,主缆无应力长度公式的计算值偏小.仅就悬索桥主缆成桥态线形确定而言,主缆线形确定的两大类数值解析算法都具有很高的工程精度,但第二类算法的主缆自重集度的确定更为精确、更接近实际情况,实际计算时应优先使用它.另外,针对两类解析算法涉及到大量的超越方程求解和递推迭代计算的情况,提出了基于MATLAB软件的高精度电算实现方法.最后,给出一个超大跨径悬索桥的中跨主缆线形确定的验证算例.%The common precise numerical analytical algorithms to determine main cables' curve shape in suspension bridges were investigated. By means of comparison among these algorithms and formulae inference, it is found that these algorithms can be reduced to two big categories of analytical ones according to different known conditions that weight intensity loads of main cables are calculated in terms of their lengths with stress and without stress under the basic hypotheses that main cables are ideally flexible and the effect of Poisson ratio of their cross-sections is neglected. It is proved that all methods among big categories of analytical ones are equivalent to each other. Moreover, further studies show that the second big category of analytical algorithms is "thoroughly precise analytical ones" and the first is quasi- precise analytical ones, and the latter one under-evaluates the length of main cables
Logging and Agricultural Residue Supply Curves for the Pacific Northwest
Kerstetter, James D.; Lyons, John Kim
2001-01-01
This report quantified the volume of logging residues at the county level for current timber harvests. The cost of recovering logging residues was determined for skidding, yearding, loading, chipping and transporting the residues. Supply curves were developed for ten candidate conversion sites in the Pacific Northwest Region. Agricultural field residues were also quantified at the county level using five-year average crop yields. Agronomic constraints were applied to arrive at the volumes available for energy use. Collection costs and transportation costs were determined and supply curves generated for thirteen candidate conversion sites.
Quantum eigenstates of curved nanowire structures
Gravesen, J. [Department of Mathematics, Technical University of Denmark, Matematiktorvet building 303, DK-2800 Kgs. Lyngby (Denmark); Willatzen, M. [Mads Clausen Institute for Product Innovation, University of Southern Denmark, Grundtvigs Alle 150, DK-6400 Sonderborg (Denmark)]. E-mail: willatzen@mci.sdu.dk
2006-01-15
Eigenstates and associated eigenvalues of a quantum-mechanical particle confined to a three-dimensional arbitrarily curved nanowire structure are determined. Special emphasis is given to the influence of nanowire geometry and curvature effects which are expected to play important roles for the physical properties of several nanowire structures recently grown in laboratories. Use of differential-geometry arguments allows separation of the three-dimensional Schroedinger equation into either (i) two partial differential equations plus one ordinary differential equation in the general nanowire cross-section case or [for simple cross-sectional nanowire shapes] (ii) three ordinary differential equations (ODEs) in appropriate curved coordinates for the case where the cross-sectional area is constant along the nanowire axis. Problems corresponding to item, (ii) with three ODEs can be solved either completely analytically or by use of a simple one-dimensional finite-difference scheme. Three case studies are finally analyzed in details: the rectangular cross-sectional-shaped nanowire with a (a) straight-line axis, (b) a circular-shaped axis, and (c) the sinusoidal-shaped nanowire axis including discussion of symmetry properties.
Galactic rotation curves in brane world models
Gergely, L Á; Dwornik, M; Kupi, G; Keresztes, Z
2011-01-01
In the braneworld scenario the four dimensional effective Einstein equation has extra source terms, which arise from the embedding of the 3-brane in the bulk. These non-local effects, generated by the free gravitational field of the bulk, may provide an explanation for the dynamics of the neutral hydrogen clouds at large distances from the galactic center, which is usually explained by postulating the existence of the dark matter. In the present paper we consider the asymptotic behavior of the galactic rotation curves in the brane world models, and we compare the theoretical results with observations of both High Surface Brightness and Low Surface Brightness galaxies. For the chosen sample of galaxies we determine first the baryonic parameters by fitting the photometric data to the adopted galaxy model; then we test the hypothesis of the Weyl fluid acting as dark matter on the chosen sample of spiral galaxies by fitting the tangential velocity equation of the combined baryonic-Weyl model to the rotation curve...
Transition curves for highway geometric design
Kobryń, Andrzej
2017-01-01
This book provides concise descriptions of the various solutions of transition curves, which can be used in geometric design of roads and highways. It presents mathematical methods and curvature functions for defining transition curves. .
Curved Gabor Filters for Fingerprint Image Enhancement
Gottschlich, Carsten
2011-01-01
Gabor filters play an important role in many application areas for the enhancement of various types of images and the extraction of Gabor features. For the purpose of enhancing curved structures in noisy images, we introduce curved Gabor filters which locally adapt their shape to the direction of flow. These curved Gabor filters enable the choice of filter parameters which increase the smoothing power without creating artifacts in the enhanced image. In this paper, curved Gabor filters are applied to the curved ridge and valley structure of low-quality fingerprint images. First, we combine two orientation field estimation methods in order to obtain a more robust estimation for very noisy images. Next, curved regions are constructed by following the respective local orientation and they are used for estimating the local ridge frequency. Lastly, curved Gabor filters are defined based on curved regions and they are applied for the enhancement of low-quality fingerprint images. Experimental results on the FVC2004...
A new approach for constructing derivative type curves for well test analysis
Onur, M.; Reynolds, A.C.
1988-03-01
Recently, type curves based on pressure derivatives have become a highly popular method for analyzing well test data. Typically, these type curves represent a log-log plot of dimensionless pressure and the derivative of dimensionless pressure vs. dimensionless time. This work presents a new general procedure for constructing type curves based on a new combination of dimensionless pressure and the derivative of dimensionless pressure. The procedure can be used to construct type curves for all standard problems encountered in well testing. The new type curves always have good character so that nonuniqueness problems sometimes encountered in type-curve matching are eliminated;p thus, the type curves constructed by our method should improve our ability to obtain accurate estimates of reservoir parameters by type-curve matching. The basic procedure is used to construct new type curves for wellbore storage and skin problems and for fractured wells (uniform-flux and infinite-conductivity). These type curves are constructed so that the vertical scale of the dimensionless derivative groups is automatically aligned with the vertical scale of the field-data derivative groups; thus, type-curve matching of field derivative data is accomplished by moving the field data plot only in the horizontal direction. This automatic alignment of the vertical scales simplifies type-curve matching and also is advantageous for determining whether field data actually represent the solution assumed by a given type curve.
Whitney's formulas for curves on surfaces
Burman, Yurii
2009-01-01
The classical Whitney formula relates the number of times an oriented plane curve cuts itself to its rotation number and the index of a base point. In this paper we generalize Whitney's formula to curves on an oriented punctured surface. To define analogs of the rotation number and the index of a base point of a curve, we fix an arbitrary vector field on the surface. Similar formulas are obtained for non-based curves.
陈锦国; 夏林密; 吕咏梅
2013-01-01
This paper discusses the standard curve producing of acetaldehyde content in bottle grade pet chips by headspace gas chromatography .The chromatographic operational details such as sample amount,linear range were studied.The repeatability and reproducibility of method are improved.The more practicable method ensure the determination accuracy of acetaldehyde content in bottle grade PET chips and its production.%论述了瓶级聚酯切片顶空气相色谱法测试乙醛含量的标准曲线制作方法，对色谱进样量、线性范围等操作细节进行了研究，使得方法的重复性和再现性得到改善，可操作性强，确保瓶片及其制品的乙醛含量测试准确。
Juel, Jacob; Olesen, Søren Schou; Olesen, Anne Estrup;
2015-01-01
INTRODUCTION: Chronic pancreatitis (CP) is an inflammatory disease that causes irreversible damage to pancreatic tissue. Pain is its most prominent symptom. In the absence of pathology suitable for endoscopic or surgical interventions, pain treatment usually includes opioids. However, opioids often...... of central sensitisation is abnormal activation of the N-methyl-D-aspartate receptor, which can be antagonised by S-ketamine. The RESET trial is investigating the analgaesic and antihyperalgesic effect of S-ketamine in patients with CP. METHODS AND ANALYSIS: 40 patients with CP will be enrolled. Patients...... include changes in patient-reported outcome measures, opioid consumption and rates of side effects. The end points are registered through the 4-week medication period and for an additional follow-up period of 8 weeks to investigate long-term effects. In addition, experimental pain measures also serves...
延迟重启机制在ONU软件升级中的应用%The Application of＂Reset Delay＂in ONU Software Upgrade
吴量; 王力生
2011-01-01
This paper proposed a mechanism of＇Reset Delay＂which was applicable to EPON system of industry network service based on analyzing the traditional ONU software upgrade solution.The invention can protect the user services from being interrupted by software download and make the function of software download more user-friendly.%针对EPON在工业网络通信中的应用，对现有的ONU软件升级方案进行改进，提出了一种延时重启的升级机制，减少ONU在升级过程中对用户业务的影响，实现了软件的平滑升级。
Sato, M S; Suzuki, M; Hayashi, H
1998-12-15
Noctiluca scintillans is a luminescent marine dinoflagellate. The life cycle of Noctiluca consists of a vegetative stage and a swarmer stage. The swarmer stage of Noctiluca is initiated by formation of a swarmer-mother cell instead of binary fission of vegetative cells. We studied the formation of swarmers under various conditions and became convinced that the cells have a strict program for the formation of swarmers which starts to operate in every cell after a defined number of cell cleavages. The probability that the program will be executed appeared to be affected by the presence of other cells. In other words, a high density of cells suppressed the expression of the program. Suppression was achieved by resetting the mechanism and was related to the number of cell divisions. Our findings provide one of the simplest examples of a mechanism by which a large population produces individuality in a group of genetically homogeneous organisms.
Ait-Haddou, Rachid
2013-02-01
We show that the generalized Bernstein bases in Müntz spaces defined by Hirschman and Widder (1949) and extended by Gelfond (1950) can be obtained as pointwise limits of the Chebyshev–Bernstein bases in Müntz spaces with respect to an interval [a,1][a,1] as the positive real number a converges to zero. Such a realization allows for concepts of curve design such as de Casteljau algorithm, blossom, dimension elevation to be transferred from the general theory of Chebyshev blossoms in Müntz spaces to these generalized Bernstein bases that we termed here as Gelfond–Bernstein bases. The advantage of working with Gelfond–Bernstein bases lies in the simplicity of the obtained concepts and algorithms as compared to their Chebyshev–Bernstein bases counterparts.
Bacterial streamers in curved microchannels
Rusconi, Roberto; Lecuyer, Sigolene; Guglielmini, Laura; Stone, Howard
2009-11-01
Biofilms, generally identified as microbial communities embedded in a self-produced matrix of extracellular polymeric substances, are involved in a wide variety of health-related problems ranging from implant-associated infections to disease transmissions and dental plaque. The usual picture of these bacterial films is that they grow and develop on surfaces. However, suspended biofilm structures, or streamers, have been found in natural environments (e.g., rivers, acid mines, hydrothermal hot springs) and are always suggested to stem from a turbulent flow. We report the formation of bacterial streamers in curved microfluidic channels. By using confocal laser microscopy we are able to directly image and characterize the spatial and temporal evolution of these filamentous structures. Such streamers, which always connect the inner corners of opposite sides of the channel, are always located in the middle plane. Numerical simulations of the flow provide evidences for an underlying hydrodynamic mechanism behind the formation of the streamers.
Optimal investment in learning-curve technologies
Della Seta, M.; Gryglewicz, S.; Kort, P.M.
2012-01-01
We study optimal investment in technologies characterized by the learning curve. There are two investment patterns depending on the shape of the learning curve. If the learning process is slow, firms invest relatively late and on a larger scale. If the curve is steep, firms invest earlier and on a s
A STUDY ON JIG DISTRIBUTION CURVE TRANSFORMATION
路迈西; 常大山; 郭珍旭
1991-01-01
An investigation of the errors resulted from distribution curve transformations using six different methods was made on the basis of 61 sets of jig performance test data from the coal preparation plants in China. The results indicate that minimum error occurred when distribution curves were transformed by keeping imperfection I constant. Generalized distribution curves are developed for jigs and their applications are discussed.
The Bezout Number of Piecewise Algebraic Curves
Dian Xuan GONG; Ren Hong WANG
2012-01-01
Based on the discussion of the number of roots of univariate spline and the common zero points of two piecewise algebraic curves,a lower upbound of Bezout number of two piecewise algebraic curves on any given non-obtuse-angled triangulation is found.Bezout number of two piecewise algebraic curves on two different partitions is also discussed in this paper.
Automated Blazar Light Curves Using Machine Learning
Johnson, Spencer James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
2017-07-27
This presentation describes a problem and methodology pertaining to automated blazar light curves. Namely, optical variability patterns for blazars require the construction of light curves and in order to generate the light curves, data must be filtered before processing to ensure quality.
AKLSQF - LEAST SQUARES CURVE FITTING
Kantak, A. V.
1994-01-01
The Least Squares Curve Fitting program, AKLSQF, computes the polynomial which will least square fit uniformly spaced data easily and efficiently. The program allows the user to specify the tolerable least squares error in the fitting or allows the user to specify the polynomial degree. In both cases AKLSQF returns the polynomial and the actual least squares fit error incurred in the operation. The data may be supplied to the routine either by direct keyboard entry or via a file. AKLSQF produces the least squares polynomial in two steps. First, the data points are least squares fitted using the orthogonal factorial polynomials. The result is then reduced to a regular polynomial using Sterling numbers of the first kind. If an error tolerance is specified, the program starts with a polynomial of degree 1 and computes the least squares fit error. The degree of the polynomial used for fitting is then increased successively until the error criterion specified by the user is met. At every step the polynomial as well as the least squares fitting error is printed to the screen. In general, the program can produce a curve fitting up to a 100 degree polynomial. All computations in the program are carried out under Double Precision format for real numbers and under long integer format for integers to provide the maximum accuracy possible. AKLSQF was written for an IBM PC X/AT or compatible using Microsoft's Quick Basic compiler. It has been implemented under DOS 3.2.1 using 23K of RAM. AKLSQF was developed in 1989.
Caloric curve of star clusters.
Casetti, Lapo; Nardini, Cesare
2012-06-01
Self-gravitating systems, such as globular clusters or elliptical galaxies, are the prototypes of many-body systems with long-range interactions, and should be the natural arena in which to test theoretical predictions on the statistical behavior of long-range-interacting systems. Systems of classical self-gravitating particles can be studied with the standard tools of equilibrium statistical mechanics, provided the potential is regularized at small length scales and the system is confined in a box. The confinement condition looks rather unphysical in general, so that it is natural to ask whether what we learn with these studies is relevant to real self-gravitating systems. In order to provide an answer to this question, we consider a basic, simple, yet effective model of globular clusters: the King model. This model describes a self-consistently confined system, without the need of any external box, but the stationary state is a nonthermal one. In particular, we consider the King model with a short-distance cutoff on the interactions, and we discuss how such a cutoff affects the caloric curve, i.e., the relation between temperature and energy. We find that the cutoff stabilizes a low-energy phase, which is absent in the King model without cutoff; the caloric curve of the model with cutoff turns out to be very similar to that of previously studied confined and regularized models, but for the absence of a high-energy gaslike phase. We briefly discuss the possible phenomenological as well as theoretical implications of these results.