Research and development project in fiscal 1990 for large industrial technologies. Achievement report on research and development of ultra-advanced processing systems (Research and development of ultra-advanced processing systems); 1990 nendo chosentan kako system no kenkyu kaihatsu seika hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1991-03-01

Research and development has been performed with an objective to establish the processing technology using excitation beam required for the advanced industries, and the ultra-precision machining technology to realize the nano-technology. This paper summarizes the achievements in fiscal 1990. In the research on the ultra-precision machining elements, experimental discussions were given on positioning and movement characteristics of static pressure feed screws in an NC equipment, wherein the intermediate target was achieved on rigidity improvement in rotating devices and accuracy in the ultra-precision positioning device. In the research on the thin film forming and laminating technology, a low temperature forming method was completed to form a diamond film at temperatures lower than 400 degrees C on such a substrate as aluminum. In the research of the ion beam surface modifying technology, researches were performed to laminate a silicon nitride layer and a phosphoric glass layer on the glass surface layer, having obtained a result that the modification can be executed in 57 minutes. A method was established to evaluate performance of Si films by measuring movement characteristics of an Si thin film transistor formed on the modified substrate, having achieved the intermediate target. (NEDO)

Identifying and Prioritizing Gaps in Neuroendocrine Tumor Research: A Modified Delphi Process With Patients and Health Care Providers to Set the Research Action Plan for the Newly Formed Commonwealth Neuroendocrine Tumor Collaboration

Directory of Open Access Journals (Sweden)

Eva Segelov

2017-08-01

Full Text Available Purpose: Neuroendocrine tumors (NETs are a diverse group of malignancies that pose challenges common to all rare tumors. The Commonwealth Neuroendocrine Tumor Collaboration (CommNETS was established in 2015 to enhance outcomes for patients with NETs in Canada, Australia, and New Zealand. A modified Delphi process was undertaken involving patients, clinicians, and researchers to identify gaps in NETs research to produce a comprehensive and defensible research action plan. Methods: A three-round modified Delphi process was undertaken with larger representation than usual for medical consensus processes. Patient/advocate and health care provider/researcher expert panels undertook Round 1, which canvassed 17 research priorities and 42 potential topics; in Round 2, these priorities were ranked. Round 3 comprised a face-to-face meeting to generate final consensus rankings and formulate the research action plan. Results: The Delphi groups consisted of 203 participants in Round 1 (64% health care providers/researchers, 36% patient/advocates; 52% Canadian, 32% Australian, and 17% New Zealander, of whom 132 participated in Round 2. The top eight priorities were biomarker development; peptide receptor radionuclide therapy optimization; trials of new agents in advanced NETs; functional imaging; sequencing therapies for metastatic NETs, including development of validated surrogate end points for studies; pathologic classification; early diagnosis; interventional therapeutics; and curative surgery. Two major areas were ranked significantly higher by patients/advocates: early diagnosis and curative surgery. Six CommNETS working parties were established. Conclusion: This modified Delphi process resulted in a well-founded set of research priorities for the newly formed CommNETS collaboration by involving a large, diverse group of stakeholders. This approach to setting a research agenda for a new collaborative group should be adopted to ensure that research plans

Identifying and Prioritizing Gaps in Neuroendocrine Tumor Research: A Modified Delphi Process With Patients and Health Care Providers to Set the Research Action Plan for the Newly Formed Commonwealth Neuroendocrine Tumor Collaboration.

Science.gov (United States)

Segelov, Eva; Chan, David; Lawrence, Ben; Pavlakis, Nick; Kennecke, Hagen F; Jackson, Christopher; Law, Calvin; Singh, Simron

2017-08-01

Neuroendocrine tumors (NETs) are a diverse group of malignancies that pose challenges common to all rare tumors. The Commonwealth Neuroendocrine Tumor Collaboration (CommNETS) was established in 2015 to enhance outcomes for patients with NETs in Canada, Australia, and New Zealand. A modified Delphi process was undertaken involving patients, clinicians, and researchers to identify gaps in NETs research to produce a comprehensive and defensible research action plan. A three-round modified Delphi process was undertaken with larger representation than usual for medical consensus processes. Patient/advocate and health care provider/researcher expert panels undertook Round 1, which canvassed 17 research priorities and 42 potential topics; in Round 2, these priorities were ranked. Round 3 comprised a face-to-face meeting to generate final consensus rankings and formulate the research action plan. The Delphi groups consisted of 203 participants in Round 1 (64% health care providers/researchers, 36% patient/advocates; 52% Canadian, 32% Australian, and 17% New Zealander), of whom 132 participated in Round 2. The top eight priorities were biomarker development; peptide receptor radionuclide therapy optimization; trials of new agents in advanced NETs; functional imaging; sequencing therapies for metastatic NETs, including development of validated surrogate end points for studies; pathologic classification; early diagnosis; interventional therapeutics; and curative surgery. Two major areas were ranked significantly higher by patients/advocates: early diagnosis and curative surgery. Six CommNETS working parties were established. This modified Delphi process resulted in a well-founded set of research priorities for the newly formed CommNETS collaboration by involving a large, diverse group of stakeholders. This approach to setting a research agenda for a new collaborative group should be adopted to ensure that research plans reflect unmet needs and priorities in the field.

Developing a new method for modifying over-allocated multi-mode resource constraint schedules in the presence of preemptive resources

Directory of Open Access Journals (Sweden)

Aidin Delgoshaei

2016-09-01

Full Text Available The issue of resource over-allocating is a big concern for project engineers in the process of scheduling project activities. Resource over-allocating is frequently seen after initial scheduling of a project in practice and causes significant amount of efforts to modify the initial schedules. In this research, a new method is developed for modifying over-allocated schedules in a multi-mode resource constrained project scheduling problems (MRCPSPs with positive cash flows (MRCPSP-PCF. The aim is to maximize profit of the MRCPSPs or logically minimizing costs. The proposed method can be used as a macro in Microsoft Office Project® Software to modify resource over-allocated days after scheduling a project. This research considers progress payment method and preemptive resources. The proposed approach maximizes profit by scheduling activities through the resource calendar respecting to the available level of preemptive resources and activity numbers. To examine the performance of the proposed method a number of experiments derived from the literature are solved. The results are then compared with the circumstances where resource constraints are relaxed. The outcomes show that in all studied cases, the proposed algorithm can provide modified schedules with no over-allocated days. Afterward the method is applied to modify a manufacturing project in practice.

Materials Processing Research and Development

Science.gov (United States)

2010-08-01

2 2.1.4 The Origins of Microstexture in Duplex Ti Alloys...Controlled Growth and Coarsening ....... 14 2.11 PUBLISHED RESEARCH ON FRICTION STIR WELDING OF SC-MODIFIED AL-ZN-MG-CU EXTRUDED PLATES...14 2.11.1 Friction Stir Welding of Sc

Software development for research reactors

International Nuclear Information System (INIS)

Krohn, J.L.; Feltz, D.E.; Khalil, N.S.

1986-01-01

The Texas A and M University Nuclear Science Center, in a program jointly sponsored with the International Atomic Energy Agency, is developing a series of computer software programs of use at research reactor facilities. The programs cover a wide range of topics including activation and shielding calculations, control rod calibrations, power calorimetrics, and fuel inventory including burnup. Many of the programs are modified and improved versions of programs already in use at the NSC that ran on outdated computing equipment. All of the new versions were written in Fortran77 on the NSC's new TI Pro microcomputer and are IBM-compatible. This paper describes the development and translation efforts in preparing the programs for use by other facilities, and gives an overview of the aim of the development effort. A brief description of each program that has been or is to be written is given including the required inputs and the resulting outputs. This paper also addresses the original needs that brought about the development program and the benefits to facility operations that each program provides. The programs discussed are available to interested parties in a hard-copy listing as requested. (author)

Monitoring vital signs: development of a modified early warning scoring (MEWS system for general wards in a developing country.

Directory of Open Access Journals (Sweden)

Una Kyriacos

Full Text Available OBJECTIVE: The aim of the study was to develop and validate, by consensus, the construct and content of an observations chart for nurses incorporating a modified early warning scoring (MEWS system for physiological parameters to be used for bedside monitoring on general wards in a public hospital in South Africa. METHODS: Delphi and modified face-to-face nominal group consensus methods were used to develop and validate a prototype observations chart that incorporated an existing UK MEWS. This informed the development of the Cape Town ward MEWS chart. PARTICIPANTS: One specialist anaesthesiologist, one emergency medicine specialist, two critical care nurses and eight senior ward nurses with expertise in bedside monitoring (N = 12 were purposively sampled for consensus development of the MEWS. One general surgeon declined and one neurosurgeon replaced the emergency medicine specialist in the final round. RESULTS: Five consensus rounds achieved ≥70% agreement for cut points in five of seven physiological parameters respiratory and heart rates, systolic BP, temperature and urine output. For conscious level and oxygen saturation a relaxed rule of <70% agreement was applied. A reporting algorithm was established and incorporated in the MEWS chart representing decision rules determining the degree of urgency. Parameters and cut points differed from those in MEWS used in developed countries. CONCLUSIONS: A MEWS for developing countries should record at least seven parameters. Experts from developing countries are best placed to stipulate cut points in physiological parameters. Further research is needed to explore the ability of the MEWS chart to identify physiological and clinical deterioration.

Modified quadrupole mass analyzer RGA-100 for beam plasma research in forevacuum pressure range

Energy Technology Data Exchange (ETDEWEB)

Zolotukhin, D. B.; Tyunkov, A. V. [Tomsk State University of Control Systems and Radioelectronics, 40 Lenin Ave., Tomsk 634050 (Russian Federation); Yushkov, Yu. G., E-mail: yuyushkov@gmail.com [Tomsk State University of Control Systems and Radioelectronics, 40 Lenin Ave., Tomsk 634050 (Russian Federation); Tomsk Polytechnic University, 30 Lenin Ave., Tomsk 634050 (Russian Federation); Oks, E. M. [Tomsk State University of Control Systems and Radioelectronics, 40 Lenin Ave., Tomsk 634050 (Russian Federation); Institute of High Current Electronics SB RAS, 2/3, Akademichesky Ave., Tomsk 634055 (Russian Federation)

2015-12-15

The industrial quadrupole RGA-100 residual gas analyzer was modified for the research of electron beam-generated plasma at forevacuum pressure range. The standard ionizer of the RGA-100 was replaced by three electrode extracting unit. We made the optimization of operation parameters in order to provide the maximum values of measured currents of any ion species. The modified analyzer was successfully tested with beam plasma of argon, nitrogen, oxygen, and hydrocarbons.

Effect modifiers in intervention research at hospitals in three Nordic countries

DEFF Research Database (Denmark)

Winkel, Jørgen; Edwards, Kasper; Jarebrant, Caroline

2016-01-01

paper aims to present assessment of potential effect modifiers in intervention studies at hospital wards in Denmark, Iceland and Sweden. Material and methods: The effect modifiers were assessed by a newly developed method (the EMA method; Edwards & Winkel 2016). It is a type of group interview including...... 3-6 participants representing all occupational groups in the investigated organization. The group is asked to write down significant changes at the workplace during the investigated period. The method also includes a semi-qualitative assessment of the potential Work Environment (WE) impact of each...... Mapping) (6 wards) or the ErgoVSM method (Jarebrant et al, 2010) where additional focus is on ergonomic issues (7 wards). Results: In total 120 interventions were implemented. However, 322 significant modifiers were assessed to have occurred during the intervention period. Of these, 120 were assessed...

Informed consent and collaborative research: perspectives from the developing world.

Science.gov (United States)

Hyder, Adnan A; Wali, Salman A

2006-03-01

Informed consent has been recognized as an important component of research protocols and procedures of disclosure and consent in collaborative research have been criticized, as they may not be in keeping with cultural norms of developing countries. This study, which is part of a larger project funded by the United States National Bioethics Advisory Commission, explores the opinions of developing country researchers regarding informed consent in collaborative research. A survey of developing country researchers, involved in human subject research, was conducted by distributing a questionnaire with 169 questions, which included questions relating to informed consent. In addition, six focus group discussions, eight in-depth interviews and 78 responses to open-ended questions in the questionnaire provided qualitative data. 203 surveys were considered complete and were included in the analysis. Written consent was not used by nearly 40% of the researchers in their most recent studies. A large proportion of respondents recommended that human subject regulations should allow more flexibility in ways of documenting informed consent. 84% of researchers agreed that a mechanism to measure understanding should be incorporated in research studies as part of the process of informed consent. This paper is an empirical step in highlighting the ethical issues concerning disclosure. Health researchers in developing countries are well aware of the importance of consent in health research, and equally value the significance of educating human subjects regarding study protocols and associated risks and benefits. However, respondents emphasize the need for modifying ethical regulations in collaborative research.

A new modified tandem appliance for management of developing Class III malocclusion

OpenAIRE

Sukh, Ram; Singh, Gyan P; Tandon, Pradeep

2013-01-01

Most developing Class III patients display a retruded maxilla. Early intervention in mixed dentition is associated with better patient compliance and possibly a better orthopedic response, which can produce favorable results. The aim of this article is to present the fabrication of the new modified tandem appliance and its use in management of developing Class III malocclusion. The therapeutic results of a new modified tandem appliance are presented in an 8 year-old male patient with anterior...

Development of Flat Roof Construction with Waterproofing from Modified Self-Compacting Concrete

Science.gov (United States)

Bogdanov, R. R.; Ibragimov, R. A.

2017-11-01

The given article considers the issues of increase of building flat roof durability by application of the modified self-compacting concrete (SSC). When SSC was modified, a complex modifier was developed and the optimization of the complex modifier composition was carried out using a three-factor experiment. The physico-mechanical properties of the obtained SSC are determined. The microstructure and phase composition of the modified cement stone were studied. On the basis of the studies carried out, namely, X-ray phase analysis and electron microscopy, it was concluded that the reduced content of calcium hydroxide in the samples with a complex modifier is due to the adsorption of calcium hydroxide on highly dispersed particles and the reaction of interaction with metakaolin also contributing to reduction in the content of calcium hydroxide in cement stone. The received data allow one to speak about SSC high operational characteristics. With the mark for the spreading of cone P5, the modified SSC has a class of compressive strength B50, high frost resistance (F600) and water resistance (W16).

Research and development program, fiscal year 1966

Energy Technology Data Exchange (ETDEWEB)

1964-04-01

The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1966 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Chemical Toxicity; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine program may be summarized as follows: (1) investigation of the effects of ionizing radiation on living organisms and systems of biological significance; (2) investigation of the dynamic aspects of physiological and biochemical processes in man, animals and plants and how these processes are modified by radiation and related pathological states; (3) the assessment and study of the immediate and long term consequences of the operation or detonation of nuclear devices on the fauna, and flora in man's environment and on man; (4) the development of methods of minimizing or preventing the detrimental effects of ionizing radiation; (5) research in, and development of, beneficial uses of ionizing radiation and radioactive substances in medicine and biology; (6) research in the development of new and more efficient radiation detection devices; (7) research, including field studies, as mutually agreed upon by the Commission and the University, in connection with the conduct of weapon tests and biomedical and civil effects experiments at such tests conducted at continental and overseas test sites; and (8) the conduct of training and educational activities in the biological and medical aspects of radiation and related fields.

Factors Considered by Elementary Teachers When Developing and Modifying Mathematical Tasks to Support Children's Mathematical Thinking

Science.gov (United States)

Fredenberg, Michael Duane

The idea that problems and tasks play a pivotal role in a mathematics lesson has a long standing in mathematics education research. Recent calls for teaching reform appeal for training teachers to better understand how students learn mathematics and to employ students' mathematical thinking as the basis for pedagogy (CCSSM, 2010; NCTM, 2000; NRC 1999). The teaching practices of (a) developing a task for a mathematics lesson and, (b) modifying the task for students while enacting the lesson fit within the scope of supporting students' mathematical thinking. Surprisingly, an extensive search of the literature did not yield any research aimed to identify and refine the constituent parts of the aforementioned teaching practices in the manner called for by Grossman and xiii colleagues (2009). Consequently, my research addresses the two questions: (a) what factors do exemplary elementary teachers consider when developing a task for a mathematics lesson? (b) what factors do they consider when they modify a task for a student when enacting a lesson? I conducted a multiple case study involving three elementary teachers, each with extensive training in the area of Cognitively Guided Instruction (CGI), as well as several years experience teaching mathematics following the principles of CGI (Carpenter et al., 1999). I recorded video of three mathematics lessons with each participant and after each lesson I conducted a semi-structured stimulated recall interview. A subsequent follow-up clinical interview was conducted soon thereafter to further explore the teacher's thoughts (Ginsberg, 1997). In addition, my methodology included interjecting myself at select times during a lesson to ask the teacher to explain her reasoning. Qualitative analysis led to a framework that identified four categories of influencing factors and seven categories of supporting objectives for the development of a task. Subsets of these factors and objectives emerged as particularly relevant when the

Development of the modified sum-peak method and its application

International Nuclear Information System (INIS)

Ogata, Y.; Miyahara, H.; Ishihara, M.; Ishigure, N.; Yamamoto, S.; Kojima, S.

2016-01-01

As the sum-peak method requires the total count rate as well as the peak count rates and the sum peak count rate, this meets difficulties when a sample contains other radionuclides than the one to be measured. To solve the problem, a new method using solely the peak and the sum peak count rates was developed. The method was theoretically and experimentally confirmed using "6"0Co, "2"2Na and "1"3"4Cs. We demonstrate that the modified sum-peak method is quite simple and practical and is useful to measure multiple nuclides. - Highlights: • A modified sum-peak method for simple radioactivity measurement was developed. • The method solely requires the peak count rates and the sum peak count rate. • The method is applicable to multiple radionuclides.

The perspective of European researchers of national occupational safety and health institutes for contributing to a European research agenda: a modified Delphi study

Science.gov (United States)

Gagliardi, Diana; Rondinone, Bruna M; Mirabile, Marco; Buresti, Giuliana; Ellwood, Peter; Hery, Michel; Paszkiewicz, Peter; Valenti, Antonio; Iavicoli, Sergio

2017-01-01

Objectives This study, developed within the frame of the Partnership for European Research on Occupational Safety and Health joint research activities and based on the frame designed by the 2013 European Agency for Safety and Health at Work (EU-OSHA) study, is the first example of using the points of view of European occupational safety and health (OSH) researchers. The objective is to identify priorities for OSH research that may contribute to the achievement of present and future sustainable growth objectives set by the European strategies. Methods The study was carried out using a modified Delphi method with a two-round survey. Each round involved a panel of about 110 researchers representing the network member institutes was selected according to specific criteria, including the ownership of research expertise in at least one of the four macroareas identified by the reference report developed by EU-OSHA in 2013. Results The study identified some innovative research topics (for example, ‘Emerging technological devices’ and ‘OSH consequences of markets integration’) and research priorities (ie, crowdsourcing, e-work, zero-hours contracts) that are not reflected in previous studies of this nature. The absence of any reference to violence and harassment at work among the researchers’ proposals is a major difference from previous similar studies, while topics related to gender issues and electromagnetic fields show a lower importance. Conclusions The innovative design of a research priorities identification process, which takes advantage of a large, representative and qualified panel of European researchers allowed the definition of a number of research priorities able to support the inclusion of innovative OSH research issues in the scope of the next European research agenda. PMID:28645965

WHEAT CHARACTERISTIC DEMAND AND IMPLICATIONS FOR DEVELOPMENT OF GENETICALLY MODIFIED GRAINS

OpenAIRE

Janzen, Edward L.; Mattson, Jeremy W.; Wilson, William W.

2001-01-01

Agricultural biotechnology is advancing rapidly and is embracing all major crops. The adoption of genetically modified corn, soybeans, and cotton have reached high levels in the United States. Wheat is the next major crop confronting the biotechnology issue, but no commercial varieties of genetically modified (GM) wheat have been released yet. Primary opportunities for GM developments in wheat center around improvements that meet consumer and end-user needs/issues in addition to meeting produ...

Development and evaluation of targeting ligands surface modified paclitaxel nanocrystals

Energy Technology Data Exchange (ETDEWEB)

Sohn, Jeong Sun [Division of Undeclared Majors, Chosun University, Gwangju 501-759 (Korea, Republic of); Yoon, Doo-Soo; Sohn, Jun Youn [Department of Bioenvironmental & Chemical Engineering, Chosun College of Science & Technology, Gwangju 501-744 (Korea, Republic of); Park, Jeong-Sook, E-mail: eicosa@cnu.ac.kr [College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134 (Korea, Republic of); Choi, Jin-Seok, E-mail: c34281@gmail.com [College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134 (Korea, Republic of)

2017-03-01

To overcome the toxicity of excipient or blank nanoparticles for drug delivery nano-system, the surface modified paclitaxel nanocrystals (PTX-NC) have been developed. PTX-NCs were prepared by nano-precipitation method. The surface of PTX-NCs were modified by grafting with apo-transferrin (Tf) or hyaluronic acid (HA). The physical properties of PTX-NCs were evaluated by field emission scanning electron microscope (FE-SEM), zeta-sizer, zeta-potential, differential scanning calorimetry (DSC) and Fourier transform infrared (FT-IR) spectrometry. In vitro drug release study was performed in phosphate buffered saline (PBS) with or without 0.5% (w/v) Tween 80 for 24 h. Cellular uptake was studied at time intervals of 0.5, 1, and 2 h in MCF-7 cells, and cell growth inhibition study was performed for 24 h using MCF-7 cells (cancer cells), and HaCaT cells (normal cells). Three different types of PTX-NCs with a mean size of 236.0 ± 100.6 nm (PTX-NC), 302.0 ± 152.0 nm (Tf-PTX-NC) and 339 ± 180.6 nm (HA-PTX-NC) were successfully prepared. The drug release profiles showed 29.1%/6.9% (PTX (pure)), 40.7%/23.9% (PTX-NC), 50.5%/25.1% (Tf-PTX-NC) and 46.8/24.8% (HA-PTX-NC) in PBS with/without 0.5% (w/v) Tween 80 for 24 h, respectively. As per the results, the drug release of PTX-NCs showed the faster release as compared to that of PTX (pure). Surface modified PTX-NCs exhibited higher values for cell permeability than unmodified PTX-NC in the cellular uptake study. Surface modified PTX-NCs inhibited the cell growth approximately to 60% in MCF-7 cells, however effect of surface modified PTX-NCs on normal cell line was lower than the PTX-NC and PTX (pure). In conclusion, biological macromolecules (Tf or HA) surface modified PTX-NC enhanced the cellular uptake and the cell growth inhibition. - Highlights: • Surface modified PTX-NCs with HA and Tf are successfully prepared by adsorption method. • Enhanced cellular uptake of modified PTX-NCs compared to unmodified PTX-NC • Improved

The perspective of European researchers of national occupational safety and health institutes for contributing to a European research agenda: a modified Delphi study.

Science.gov (United States)

Gagliardi, Diana; Rondinone, Bruna M; Mirabile, Marco; Buresti, Giuliana; Ellwood, Peter; Hery, Michel; Paszkiewicz, Peter; Valenti, Antonio; Iavicoli, Sergio

2017-06-23

This study, developed within the frame of the Partnership for European Research on Occupational Safety and Health joint research activities and based on the frame designed by the 2013 European Agency for Safety and Health at Work (EU-OSHA) study, is the first example of using the points of view of European occupational safety and health (OSH) researchers.The objective is to identify priorities for OSH research that may contribute to the achievement of present and future sustainable growth objectives set by the European strategies. The study was carried out using a modified Delphi method with a two-round survey. Each round involved a panel of about 110 researchers representing the network member institutes was selected according to specific criteria, including the ownership of research expertise in at least one of the four macroareas identified by the reference report developed by EU-OSHA in 2013. The study identified some innovative research topics (for example, 'Emerging technological devices' and 'OSH consequences of markets integration') and research priorities (ie, crowdsourcing, e-work, zero-hours contract s ) that are not reflected in previous studies of this nature.The absence of any reference to violence and harassment at work among the researchers' proposals is a major difference from previous similar studies, while topics related to gender issues and electromagnetic fields show a lower importance. The innovative design of a research priorities identification process, which takes advantage of a large, representative and qualified panel of European researchers allowed the definition of a number of research priorities able to support the inclusion of innovative OSH research issues in the scope of the next European research agenda. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Hardware Development Process for Human Research Facility Applications

Science.gov (United States)

Bauer, Liz

2000-01-01

The simple goal of the Human Research Facility (HRF) is to conduct human research experiments on the International Space Station (ISS) astronauts during long-duration missions. This is accomplished by providing integration and operation of the necessary hardware and software capabilities. A typical hardware development flow consists of five stages: functional inputs and requirements definition, market research, design life cycle through hardware delivery, crew training, and mission support. The purpose of this presentation is to guide the audience through the early hardware development process: requirement definition through selecting a development path. Specific HRF equipment is used to illustrate the hardware development paths. The source of hardware requirements is the science community and HRF program. The HRF Science Working Group, consisting of SCientists from various medical disciplines, defined a basic set of equipment with functional requirements. This established the performance requirements of the hardware. HRF program requirements focus on making the hardware safe and operational in a space environment. This includes structural, thermal, human factors, and material requirements. Science and HRF program requirements are defined in a hardware requirements document which includes verification methods. Once the hardware is fabricated, requirements are verified by inspection, test, analysis, or demonstration. All data is compiled and reviewed to certify the hardware for flight. Obviously, the basis for all hardware development activities is requirement definition. Full and complete requirement definition is ideal prior to initiating the hardware development. However, this is generally not the case, but the hardware team typically has functional inputs as a guide. The first step is for engineers to conduct market research based on the functional inputs provided by scientists. CommerCially available products are evaluated against the science requirements as

Parent-child mediated learning interactions as determinants of cognitive modifiability: recent research and future directions.

Science.gov (United States)

Tzuriel, D

1999-05-01

The main objectives of this article are to describe the effects of mediated learning experience (MLE) strategies in mother-child interactions on the child's cognitive modifiability, the effects of distal factors (e.g., socioeconomic status, mother's intelligence, child's personality) on MLE interactions, and the effects of situational variables on MLE processes. Methodological aspects of measurement of MLE interactions and of cognitive modifiability, using a dynamic assessment approach, are discussed. Studies with infants showed that the quality of mother-infant MLE interactions predict later cognitive functioning and that MLE patterns and children's cognitive performance change as a result of intervention programs. Studies with preschool and school-aged children showed that MLE interactions predict cognitive modifiability and that distal factors predict MLE interactions but not the child's cognitive modifiability. The child's cognitive modifiability was predicted by MLE interactions in a structured but not in a free-play situation. Mediation for transcendence (e.g., teaching rules and generalizations) appeared to be the strongest predictor of children's cognitive modifiability. Discussion of future research includes the consideration of a holistic transactional approach, which refers to MLE processes, personality, and motivational-affective factors, the cultural context of mediation, perception of the whole family as a mediational unit, and the "mediational normative scripts."

Development of modified piping evaluation diagram for LBB application to Korean next generation reactor

International Nuclear Information System (INIS)

Huh, Nam Su; Kim, Young Jin; Pyo, Chang ryul; Yu, Young Jun; Yang, Jun Seog

1999-01-01

Recently, the Piping Evaluation Diagram (PED) is accepted in nuclear industry for simple application of Leak-Before-Break (LBB) concept to piping system. By utilizing the PED, the LBB concept is applied before the piping layout is finalized. However, the developed PED may have to be modified to account for the difference between the material properties of the PED development stage and those of the assembly stage. The objective of this paper is to develop the modified PED which can account for the variation of material properties. For this purpose, a parametric study was performed to investigate the effect of stress-strain curve on the detectable crack length and the effect of fracture resistance curve on the LBB allowable load. Finite element analyses were also performed to investigate the effect of stress-strain curve on the LBB allowable load. Finally a modified PED is developed as a function of crack length (DLC and 2xDLC) and the allowable Safe shutdown Earthquake (SSE) load. By adopting the modified PED, the variation of material properties can be considered in the LBB analysis and the computer runs required for the LBB analysis can be considerably reduced

Modified Protein Improves Vitiligo Symptoms in Mice

Science.gov (United States)

... Vitiligo Symptoms in Mice Spotlight on Research Modified Protein Improves Vitiligo Symptoms in Mice By Colleen Labbe, ... D., Ph.D., Rush University. Altering a key protein involved in the development of vitiligo may protect ...

Development and characterization of ferrihydrite-modified diatomite as a phosphorus adsorbent.

Science.gov (United States)

Xiong, Wenhui; Peng, Jian

2008-12-01

A novel phosphorus adsorbent, ferrihydrite-modified diatomite was developed and characterized in this study. The ferrihydrite-modified diatomite was made through surface modification treatments including NaOH treatment and ferrihydrite deposition on raw diatomite. In the NaOH treatment, surface SiO(2) of diatomite was partially dissolved in the NaOH solution. The dissolved Si contributed to form the stable 2-line ferrihydrite which deposited into the macropores and mesopores of diatomite. Blocking macropores and larger mesopores of diatomite with 0.24g Fe/g of 2-line ferrihydrite resulted in a specific surface area of 211.1m(2)/g for the ferrihydrite-modified diatomite, which is 8.5-fold increase than the raw diatomite (24.77m(2)/g). The surface modification also increased the point of zero charge (pH(PZC)) values to 10 for the ferrihydrite-modified diatomite from 5.8 for the raw diatomite. Because of the increased surface area and surface charge, the maximum adsorption capacity of ferrihydrite-modified diatomite at pH 4 and pH 8.5 was increased from 10.2mgP/g and 1.7mgP/g of raw diatomite to 37.3mgP/g and 13.6mgP/g, respectively.

Decision-making process to shut down, refurbish/modify, or decommission research reactors

International Nuclear Information System (INIS)

Stover, R.L.; Murphie, W.E.

1992-01-01

Most US research reactors were built more than 20 years ago and some more than 40 years ago. Many have undergone refurbishments and modifications to update their safety systems and experimental capabilities. But changing safety bases, social concerns, and budget constraints have required research reactor operators to continually make decisions to shut down or refurbish/modify their facilities. These decisions involve potential replacement of reactor equipment that has reached its lifetime limits. Changes in philosophy and operation of the reactors are also factors to be considered. In this paper, each of the four factors involved in the decision-making process are discussed in detail. Then, several examples from DOE research reactors in the United States are discussed. Finally, some general conclusions are given to aid in the decision-making process

The effect of modified potato flour substitution on the organoleptics characteristics of toddler biscuit

Science.gov (United States)

Cakrawati, Dewi; Rahmawati, Puji

2016-04-01

Toddler biscuit is complementary food given to infants to help meet their nutritional needs. This research was undertaken to develop toddler biscuit with subtitution of physically modified potato flour. There were two puposes of the research, first to know the characteristics of physically modification on potato flour; secondly to know biscuit characteristics with modified potato flour substitution. There were two factor analysis in the development of biscuit; first factor was pre heating mehods and substitution rate. The research was conducted with experimental method using split plot design. The functional properties on modified potato flour as swelling capacity, water absorption capacity, solubility and viscocity were analyzed. Organoleptic analysis using quality hedonic test showed no interaction between potato starch modification and concentration of modified potato flour. Quality hedonic test showed all toddler biscuit socred in the range of “slightly like” to “like moderately”. Modifying potato starch by boiling and steaming with flour concentration of 30% producing toddler biscuit with organoleptic characteristics acceptable according to the panelists.

Implant materials modified by colloids

Directory of Open Access Journals (Sweden)

Zboromirska-Wnukiewicz Beata

2016-03-01

Full Text Available Recent advances in general medicine led to the development of biomaterials. Implant material should be characterized by a high biocompatibility to the tissue and appropriate functionality, i.e. to have high mechanical and electrical strength and be stable in an electrolyte environment – these are the most important properties of bioceramic materials. Considerations of biomaterials design embrace also electrical properties occurring on the implant-body fluid interface and consequently the electrokinetic potential, which can be altered by modifying the surface of the implant. In this work, the surface of the implants was modified to decrease the risk of infection by using metal colloids. Nanocolloids were obtained using different chemical and electrical methods. It was found that the colloids obtained by physical and electrical methods are more stable than colloids obtained by chemical route. In this work the surface of modified corundum implants was investigated. The implant modified by nanosilver, obtained by electrical method was selected. The in vivo research on animals was carried out. Clinical observations showed that the implants with modified surface could be applied to wounds caused by atherosclerotic skeleton, for curing the chronic and bacterial inflammations as well as for skeletal reconstruction surgery.

Fix it first : utilizing the seismic property analyzer and MMLS to develop guidelines for the use of polymer modified thin lift HMA vs. surface treatments.

Science.gov (United States)

2012-09-01

The main objective of this study was to develop thin lift overlay mixtures with polymer modified asphalt for use in New England. As part of this : research a comprehensive literature review and internet survey was conducted. Moreover, laboratory test...

Research on the Microstructure and Property of an Anion Rubber Modified Asphalt

Directory of Open Access Journals (Sweden)

Wei Hong

2013-01-01

Full Text Available The anion rubber modified asphalt (ARMA mixture was first successfully developed with a unique process. In the development process, rubber and asphalt were mixed in the same proportion. Furthermore, the microstructure and modification mechanism of the material were characterized by SEM, FT-IR, TG, and XRD tests. The mechanical property of the mixture was also tested in accordance with the relevant standards. In the end, the material’s capacity of releasing anion was measured by DLY-6A232 atmospheric ion gauge. The results indicated that the addition of anion additive into the rubber modified asphalt (RMA was a mere physical mixture, and the anion additives and rubber particles uniformly dispersed in the ARMA. The addition of anion additive could improve the thermal stability of the RMA. Compared with the traditional asphalt pavement material, the ARMA material shows excellent mechanical properties as well as the ability of releasing anion. Moreover, the material has enormous economic and social benefits by taking full advantage of a large amount of waste tires, thus improving the road surrounding environment.

Developing and Improving Modified Achievement Level Descriptors: Rationale, Procedures, and Tools

Science.gov (United States)

Quenemoen, Rachel; Albus, Debra; Rogers, Chris; Lazarus, Sheryl

2010-01-01

Some states are developing alternate assessments based on modified achievement standards (AA-MAS) to measure the academic achievement of some students with disabilities (Albus, Lazarus, Thurlow, & Cormier, 2009; Lazarus, Thurlow, Christensen, & Cormier, 2007). These assessments measure the same content as the general assessment for a given…

[Development and validation of the Chinese version of modified body imgae scale in Chinese population].

Science.gov (United States)

Gao, X X; Zhu, L; Yu, S J; Xu, T

2018-02-25

Objective: To develop the Chinese version of modified body image scale (MBIS) questionnaires, and to validate them in Chinese population. Methods: The original English MBIS questionnaire was translated into Chinese, following the WHO cross-cultural adaptation of health-related quality of life measures. The reliability and validity of the Chinese version of MBIS questionnaires were evaluated in Chinese population, MRKH syndrome patients. Results: Totally 50 patients with MRKH syndrome completed the MBIS and short-form 12-item health survey (SF-12) questionnaires. The Cronbach's alpha of MBIS was 0.741, intraclass correlation coefficients were 0.472-0.815 ( PChinese version of MBIS has high reliability and validity in Chinese population, therefore is suitable for clinic and research.

Development of a modified vermireactor for efficient vermicomposting: a laboratory study.

Science.gov (United States)

Jain, K; Singh, J; Gupta, S K

2003-12-01

Waste has become an index of growth. Utilization of waste materials for productivity purposes is important for both economic and environmental reasons. Vermicomposting is an important aspect as it converts waste to wealth. In this context, a modified vermireactor in place of the conventional vermireactor for efficient vermicomposting has been developed. In the conventional low- and high-rate vermireactors, the space for vermicomposting is reduced due to the thick layer of vermibed at the bottom of the reactor, thus a small amount of worm casts is produced. In the modified vermireactors there was only a thick moist cloth at the bottom in place of the thick vermibed which allowed a comparatively large quantity of organic waste to be vermicomposted as compared to conventional vermireactors. Laboratory studies showed that the modified vermireactor performed better than the conventional vermireactor in average vermicast produced and mg castings l(-1) (digester volume) day(-1). The study further showed that only the volume of the vermireactor was responsible for the high yield of worm casts.

Performance research on modified KCS (Kalina cycle system) 11 without throttle valve

International Nuclear Information System (INIS)

He, Jiacheng; Liu, Chao; Xu, Xiaoxiao; Li, Yourong; Wu, Shuangying; Xu, Jinliang

2014-01-01

Two modified systems based on a KCS (Kalina cycle system) 11 with a two-phase expander to substitute a throttle valve are proposed. The two-phase expander is located between the regenerator and the absorber in the B-modified cycle and between the separator and the regenerator in the C-modified cycle. A thermodynamic performance analysis of both the original KCS 11 and the modified systems is carried out. The optimization of two key parameters (the concentration of working fluid and the temperature of cooling water) is also conducted. It is shown that the two modified cycles have different performance under the investigated conditions. Results also indicate that the C-modified cycle can obtain better thermodynamic effect than the B-modified cycle. The temperature of cooling water plays an important role in improving the system performance. When the cooling water temperature drops from 303 K to 278 K, the C-modified cycle thermal efficiency can be improved by 27%. - Highlights: • Throttling valve is replaced by a two-phase expander to recover the expansion work. • Thermodynamic performance of two modified cycle systems is very different. • The maximum increase of work output by C-modified cycle compared with KCS (Kalina cycle system) 11 is 9.4%. • The ranges of ammonia content of B-modified cycle are rather larger

Investigation of properties of modified oxides structured by nano technology

International Nuclear Information System (INIS)

Kurina, I.S.; Serebrennikova, O.V.; Rumyantsev, V.N.; Dvoryashin, A.M.

2009-01-01

Research results on the PuO 2 +MgO fuel composition with CeO 2 as a PuO 2 simulator are presented. The water nano technology for the production of oxide ceramic materials, developed in IPPE, was used for fabrication of powders and modified pellets. This technology includes obtaining precipitate, consisting of particles of different sizes as well as of nanoparticles, which is further calcined, pressed and sintered. It results in modifying structure of the sintered pellets. Modified pellets have anomalously high thermal conductivity measured by the axial heat flux method [ru

A new modified tandem appliance for management of developing Class III malocclusion

Directory of Open Access Journals (Sweden)

Ram Sukh

2013-01-01

Full Text Available Most developing Class III patients display a retruded maxilla. Early intervention in mixed dentition is associated with better patient compliance and possibly a better orthopedic response, which can produce favorable results. The aim of this article is to present the fabrication of the new modified tandem appliance and its use in management of developing Class III malocclusion. The therapeutic results of a new modified tandem appliance are presented in an 8 year-old male patient with anterior cross bite and retrognathic maxilla at the mixed dentition stage. Anterior cross bite was corrected in 3 months and the positive overjet of 4 mm after continued use of the appliance for 1 year. There was a significant improvement in profile of the patient. The use of this appliance in this type of malocclusion enabled the correction of malocclusion in a few months and encouraging favorable skeletal growth in the future.

A new modified tandem appliance for management of developing Class III malocclusion.

Science.gov (United States)

Sukh, Ram; Singh, Gyan P; Tandon, Pradeep

2013-10-01

Most developing Class III patients display a retruded maxilla. Early intervention in mixed dentition is associated with better patient compliance and possibly a better orthopedic response, which can produce favorable results. The aim of this article is to present the fabrication of the new modified tandem appliance and its use in management of developing Class III malocclusion. The therapeutic results of a new modified tandem appliance are presented in an 8 year-old male patient with anterior cross bite and retrognathic maxilla at the mixed dentition stage. Anterior cross bite was corrected in 3 months and the positive overjet of 4 mm after continued use of the appliance for 1 year. There was a significant improvement in profile of the patient. The use of this appliance in this type of malocclusion enabled the correction of malocclusion in a few months and encouraging favorable skeletal growth in the future.

[Concept extraction of graduate research by modified grounded theory approach and creating of rubric oriented to performance evaluation].

Science.gov (United States)

Yasuhara, Tomohisa; Sone, Tomomichi; Kohno, Takeyuki; Ogita, Kiyokazu

2015-01-01

  A revised core curriculum model for pharmaceutical education, developed on the basis of the principles of outcome-based education, will be introduced in 2015. Inevitably, appropriate assessments of students' academic achievements will be required. Although evaluations of the cognitive domain can be carried out by paper tests, evaluation methods for the attitude domain and problem-solving abilities need to be established. From the viewpoint of quality assurance for graduates, pharmaceutical education reforms have become vital to evaluation as well as learning strategies. To evaluate student academic achievements on problem-solving abilities, authentic assessment is required. Authentic assessment is the evaluation that mimics the context tried in work and life. Specifically, direct evaluation of performances, demonstration or the learners' own work with integrated variety knowledge and skills, is required. To clarify the process of graduate research, we obtained qualitative data through focus group interviews with six teachers and analyzed the data using the modified grounded theory approach. Based on the results, we clarify the performance students should show in graduate research and create a rubric for evaluation of performance in graduate research.

Chartered Society of Physiotherapy's identification of national research priorities for physiotherapy using a modified Delphi technique.

Science.gov (United States)

Rankin, Gabrielle; Rushton, Alison; Olver, Pat; Moore, Ann

2012-09-01

To define research priorities to strategically inform the evidence base for physiotherapy practice. A modified Delphi method using SurveyMonkey software identified priorities for physiotherapy research through national consensus. An iterative process of three rounds provided feedback. Round 1 requested five priorities using pre-defined prioritisation criteria. Content analysis identified research themes and topics. Round 2 requested rating of the importance of the research topics using a 1-5 Likert scale. Round 3 requested a further process of rating. Quantitative and qualitative data informed decision-making. Level of consensus was established as mean rating ≥ 3.5, coefficient of variation ≤ 30%, and ≥ 55% agreement. Consensus across participants was evaluated using Kendall's W. Four expert panels (n=40-61) encompassing a range of stakeholders and reflecting four core areas of physiotherapy practice were established by steering groups (n=204 participants overall). Response rates of 53-78% across three rounds were good. The identification of 24/185 topics for musculoskeletal, 43/174 for neurology, 30/120 for cardiorespiratory and medical rehabilitation, and 30/113 for mental and physical health and wellbeing as priorities demonstrated discrimination of the process. Consensus between participants was good for most topics. Measurement validity of the research topics was good. The involvement of multiple stakeholders as participants ensured the current context of the intended use of the priorities. From a process of national consensus involving key stakeholders, including service users, physiotherapy research topics have been identified and prioritised. Setting priorities provides a vision of how research can contribute to the developing research base in physiotherapy to maximise focus. Copyright © 2012 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

Development and validation of modified disease activity scores in rheumatoid arthritis

DEFF Research Database (Denmark)

Baker, Joshua F; Conaghan, Philip G; Smolen, Josef S

2014-01-01

-CDAI) were generated for each subject in the validation cohort. The M-DAS28, M-SDAI, and M-CDAI scores were compared to conventional scores of disease activity with regard to associations with MRI measures of synovitis and radiographic progression, assessed using Pearson's and Spearman's correlations, linear......OBJECTIVE: To develop and validate composite disease activity scores, based on widely available clinical measures, that would demonstrate improved correlation with detection of synovitis on magnetic resonance imaging (MRI) and radiographic progression, in comparison with conventional measures.......15 × SJC28 + 0.22 × EvGA + 1 and M-SDAI = CRP + SJC28 + EvGA. Both modified and conventional disease activity scores correlated significantly with MRI measures of synovitis. Modified scores showed superior correlation with synovitis, as compared to conventional scores, at all time points (P

Research and Development in the Anthropogenic Cryosphere

Science.gov (United States)

de Jong, C.; Luthe, T.; Hohenwallne, D.

2009-04-01

Much of todays cryosphere research is oriented towards the polar regions and is strongly supported by large associations and funding. On the other hand, funding and institutional support is still limited for mountains. In Europe, mountain research is mainly funded through Alpine Space Interregs, FP7, ESF and COST. However, there is growing global change pressure on mountain regions, particularly in the more fragile, higher altitudes such as between 1000 - 3200 m in the Alps. Although these zones are comparable to the Arctic in terms of climatic and physiographic conditions, they are not in terms of human pressures and atmospheric pollution released from surrounding agglomerations. A re-orientation of research into more applied projects that tackle present day problems is necessary. Not only is climate change rapidly changing the face of mountains, socio-economic multipliers are also acting fast. New problems such as conflicts over natural resources are evolving at a rapid rate, requiring research funding and projects to respond at according rates if timely and efficient solutions are to be proposed. Other problems include contamination of high altitude lakes and ecosystems through atmospheric precipitation of persistent organic pollutants and concentration of radio-active substances. The rapid melt of glacier ice is also releasing pollutants that have been captured for many decades. Many of the present day problems develop due to a miscomprehension of the cryosphere. Short-term economical reasoning outweighs the long-term ecological impacts that could be very counter-productive at the long term. Both the glaciological, snow, permafrost, geomorphological, ecological, hydrological and atmospheric conditions are increasingly heavily modified by human impacts. The effects include the alteration of the ice cover (by artificial covering of glaciers), production of artificial snow cover, snow and ground compaction, erosion, landsliding, change in vegetation cover and

Development of Research Reactor Simulator and Its Application to Dynamic Test-bed

International Nuclear Information System (INIS)

Kwon, Kee Choon; Park, Jae Chang; Lee, Seung Wook; Bang, Dane; Bae, Sung Won

2014-01-01

We developed HANARO and the Jordan Research and Training Reactor (JRTR) real-time simulator for operating staff training. The main purpose of this simulator is operator training, but we modified this simulator as a dynamic test-bed to test the reactor regulating system in HANARO or JRTR before installation. The simulator configuration is divided into hardware and software. The simulator hardware consists of a host computer, 6 operator stations, a network switch, and a large display panel. The simulator software is divided into three major parts: a mathematical modeling module, which executes the plant dynamic modeling program in real-time, an instructor station module that manages user instructions, and a human machine interface (HMI) module. The developed research reactors are installed in the Korea Atomic Energy Research Institute nuclear training center for reactor operator training. To use the simulator as a dynamic test-bed, the reactor regulating system modeling software of the simulator was replaced by a hardware controller and the simulator and target controller were interfaced with a hard-wired and network-based interface

Development of Research Reactor Simulator and Its Application to Dynamic Test-bed

Energy Technology Data Exchange (ETDEWEB)

Kwon, Kee Choon; Park, Jae Chang; Lee, Seung Wook; Bang, Dane; Bae, Sung Won [KAERI, Daejeon (Korea, Republic of)

2014-08-15

We developed HANARO and the Jordan Research and Training Reactor (JRTR) real-time simulator for operating staff training. The main purpose of this simulator is operator training, but we modified this simulator as a dynamic test-bed to test the reactor regulating system in HANARO or JRTR before installation. The simulator configuration is divided into hardware and software. The simulator hardware consists of a host computer, 6 operator stations, a network switch, and a large display panel. The simulator software is divided into three major parts: a mathematical modeling module, which executes the plant dynamic modeling program in real-time, an instructor station module that manages user instructions, and a human machine interface (HMI) module. The developed research reactors are installed in the Korea Atomic Energy Research Institute nuclear training center for reactor operator training. To use the simulator as a dynamic test-bed, the reactor regulating system modeling software of the simulator was replaced by a hardware controller and the simulator and target controller were interfaced with a hard-wired and network-based interface.

Development of modified rational buyer auction for procurement of ancillary services utilizing participation matrix

International Nuclear Information System (INIS)

Jamalzadeh, R.; Ardehali, M.M.; Rashidinejad, M.

2008-01-01

The rational buyer auction is based on a simultaneous auction that is the redesigned auction mechanism for ancillary services by the California independent system operator (CAISO). The incentive for the rational buyer auction is CAISO's intent to adopt a common sense rule of substituting higher-quality lower-cost services for lower-quality higher-cost services, when it results in reduced total procurement cost. For the purposes of designing a desirable auction where the minimum cost for the objective function as well as prevention of price reversal are achieved, either the payment cost in marginal pricing auction must be lowered or price reversal in rational buyer auction must be avoided. The objectives of this study are (a) to develop a newly proposed 'modified rational buyer' auction that does not allow price reversal and (b) to propose and validate a solution procedure that is based on participation matrix and discrete programming. The validation of the proposed solution procedure is accomplished through examination of two case studies available in the literature. Based on the first case study data, it is shown that the newly developed modified rational buyer auction avoids price reversal occurrence, while the total payment of ISO is increased by 5.8%, as compared with rational buyer auction. Also in comparison with marginal pricing auction, the ISO payment is lowered by 38.8%, when the newly developed modified rational buyer auction is utilized. For future work, it is recommended that the application of the modified rational buyer auction to joint dispatch of energy and ancillary services is investigated

Modifying the Clinical Research Infrastructure at a Dedicated Clinical Trials Unit: Assessment of Trial Development, Activation, and Participant Accrual.

Science.gov (United States)

Tang, Chad; Hess, Kenneth R; Sanders, Dwana; Davis, Suzanne E; Buzdar, Aman U; Kurzrock, Razelle; Lee, J Jack; Meric-Bernstam, Funda; Hong, David S

2017-03-15

Purpose: Information on processes for trials assessing investigational therapeutics is sparse. We assessed the trial development processes within the Department of Investigational Cancer Therapeutics (ICT) at MD Anderson Cancer Center (Houston, TX) and analyzed their effects on the trial activation timeline and enrolment. Experimental Design: Data were from a prospectively maintained registry that tracks all clinical studies at MD Anderson. From this database, we identified 2,261 activated phase I-III trials; 221 were done at the ICT. ICT trials were matched to trials from other MD Anderson departments by phase, sponsorship, and submission year. Trial performance metrics were compared with paired Wilcoxon signed rank tests. Results: We identified three facets of the ICT research infrastructure: parallel processing of trial approval steps; a physician-led research team; and regular weekly meetings to foster research accountability. Separate analyses were conducted stratified by sponsorship [industry (133 ICT and 133 non-ICT trials) or institutional (68 ICT and 68 non-ICT trials)]. ICT trial development was faster from IRB approval to activation (median difference of 1.1 months for industry-sponsored trials vs. 2.3 months for institutional) and from activation to first enrolment (median difference of 0.3 months for industry vs. 1.2 months for institutional; all matched P infrastructure within a large academic cancer center was associated with efficient trial development and participant accrual. Clin Cancer Res; 23(6); 1407-13. ©2016 AACR . ©2016 American Association for Cancer Research.

Changing Research Practices and Research Infrastructure Development

Science.gov (United States)

Houghton, John W.

2005-01-01

This paper examines changing research practices in the digital environment and draws out implications for the development of research infrastructure. Reviews of the literature, quantitative indicators of research activities and our own field research in Australia suggest that there is a new mode of knowledge production emerging, changing research…

Priorities for methodological research on patient and public involvement in clinical trials: A modified Delphi process.

Science.gov (United States)

Kearney, Anna; Williamson, Paula; Young, Bridget; Bagley, Heather; Gamble, Carrol; Denegri, Simon; Muir, Delia; Simon, Natalie A; Thomas, Stephen; Elliot, Jim T; Bulbeck, Helen; Crocker, Joanna C; Planner, Claire; Vale, Claire; Clarke, Mike; Sprosen, Tim; Woolfall, Kerry

2017-12-01

Despite increasing international interest, there is a lack of evidence about the most efficient, effective and acceptable ways to implement patient and public involvement (PPI) in clinical trials. To identify the priorities of UK PPI stakeholders for methodological research to help resolve uncertainties about PPI in clinical trials. A modified Delphi process including a two round online survey and a stakeholder consensus meeting. In total, 237 people registered of whom 219 (92%) completed the first round. One hundred and eighty-seven of 219 (85%) completed the second; 25 stakeholders attended the consensus meeting. Round 1 of the survey comprised 36 topics; 42 topics were considered in round 2 and at the consensus meeting. Approximately 96% of meeting participants rated the top three topics as equally important. These were as follows: developing strong and productive working relationships between researchers and PPI contributors; exploring PPI practices in selecting trial outcomes of importance to patients; and a systematic review of PPI activity to improve the accessibility and usefulness of trial information (eg participant information sheets) for participants. The prioritized methodological research topics indicate important areas of uncertainty about PPI in trials. Addressing these uncertainties will be critical to enhancing PPI. Our findings should be used in the planning and funding of PPI in clinical trials to help focus research efforts and minimize waste. © 2017 The Authors Health Expectations Published by John Wiley & Sons Ltd.

A comparative analysis of modified binders : original asphalts and materials extracted from existing pavements : technical summary.

Science.gov (United States)

2010-01-01

The initial objective of this research was to develop procedures and standards for applying GPC as an analytical tool to define the percentage amounts of polymer modifiers in polymer modified asphalt cements soluble in eluting GPC solvents. Quantific...

Development of polymer films by the coalescence of polymer particles in powdered and aqueous polymer-modified mortars

International Nuclear Information System (INIS)

Afridi, M.U.K.; Ohama, Y.; Demura, K.; Iqbal, M.Z.

2003-01-01

This paper evaluates and compares the coalescence of polymer particles (continuous polymer films formation) in powdered polymer-modified mortars (PPMMs) and aqueous polymer-modified mortars (APMMs). Polymer-modified mortars (PMMs) using various redispersible polymer powders (powdered cement modifiers) and polymer dispersions (aqueous cement modifiers) were prepared by varying the polymer-cement ratio (P/C) and were tested for the characterization of polymer films using a scanning electron microscope (SEM) after curing for 28 days. It is concluded from the test results that mortar constituents of unmodified mortar (UMM) are loosely joined with each other due to the absence of polymer films, thus having a structure with comparatively lower mechanical and durability characteristics. By contrast, mortar constituents in PPMMs and APMMs are compactly joined with each other due to the presence of interweaving polymer films, thereby forming a monolithic structure with improved mechanical and durability characteristics. However, the results make obvious the poor coalescence of polymer particles or development of inferior quality polymers films in PPMMs as compared to that observed in APMMs. Moreover, PPMMs show less uniform distribution of polymer films as compared to that in APMMs. Different powdered cement modifiers have different film-forming capabilities. However, such difference is hardly recognized in aqueous cement modifiers. The polymer films in PPMMs and APMMs may acquire different structures. They may appear as mesh-like, thread-like, rugged, dense or fibrous with fine or rough surfaces. Development of coherent polymer films is not well pronounced at a P/C of 5% in PPMMs, whereas sometimes coherent polymer films are observed at a P/C of 5% in APMMs. At a P/C of 10% or more, fully developed, coherent polymer films are observed in both PPMMs and APMMs

Research tools | IDRC - International Development Research Centre

International Development Research Centre (IDRC) Digital Library (Canada)

Through training materials and guides, we aim to build skills and knowledge to enhance the quality of development research. We also offer free access to our database of funded research projects, known as IDRIS+, and our digital library. Our research tools include. Guide to research databases at IDRC: How to access and ...

Research Librarian | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Job Summary The Research Librarian is a key member of a team responsible for the delivery of comprehensive research information services which contribute strategic value to the work of clients. Intermediated search services at the expert level, the development and delivery of orientations, training/coaching, ...

Modifying a Research-Based Problem-Solving Intervention to Improve the Problem-Solving Performance of Fifth and Sixth Graders With and Without Learning Disabilities.

Science.gov (United States)

Krawec, Jennifer; Huang, Jia

The purpose of the present study was to test the efficacy of a modified cognitive strategy instructional intervention originally developed to improve the mathematical problem solving of middle and high school students with learning disabilities (LD). Fifth and sixth grade general education mathematics teachers and their students of varying ability (i.e., average-achieving [AA] students, low-achieving [LA] students, and students with LD) participated in the research study. Several features of the intervention were modified, including (a) explicitness of instruction, (b) emphasis on meta-cognition, (c) focus on problem-solving prerequisites, (d) extended duration of initial intervention, and (e) addition of visual supports. General education math teachers taught all instructional sessions to their inclusive classrooms. Curriculum-based measures (CBMs) of math problem solving were administered five times over the course of the year. A multilevel model (repeated measures nested within students and students nested within schools) was used to analyze student progress on CBMs. Though CBM scores in the intervention group were initially lower than that of the comparison group, intervention students improved significantly more in the first phase, with no differences in the second phase. Implications for instruction are discussed as well as directions for future research.

Research and development

Energy Technology Data Exchange (ETDEWEB)

Harlow, Jr, J G

1977-09-01

The need for increased research and development programs to provide technological advances to meet future energy demands, particularly electric power demands, is discussed. It is concluded that the future energy needs of the world can only be supplied through technological improvements. The cost of these technological improvements can be minimized by cooperative, unified research and development programs. The financial support of the energy industry, the equipment manufacturing industry and the consumer will be required to finance these vital developments. The energy problems of the world can be solved by an adequately financed unified R and D effort. The U.S. must assume a major role of leadership in this world-wide effort. (LCL)

Search for minimal paths in modified networks

International Nuclear Information System (INIS)

Yeh, W.-C.

2002-01-01

The problem of searching for all minimal paths (MPs) in a network obtained by modifying the original network, e.g. for network expansion or reinforcement, is discussed and solved in this study. The existing best-known method to solve this problem was a straightforward approach. It needed extensive comparison and verification, and failed to solve some special but important cases. Therefore, a more efficient, intuitive and generalized method to search for all MPs without an extensive research procedure is proposed. In this presentation, first we develop an intuitive algorithm based upon the reformation of all MPs in the original network to search for all MPs in a modified network. Next, the computational complexity of the proposed algorithm is analyzed and compared with the existing methods. Finally, examples illustrate how all MPs are generated in a modified network based upon the reformation of all of the MPs in the corresponding original network

The Effects of Modified Games on the Development of Gross Motor Skill in Preschoolers

Science.gov (United States)

Lestari, Indah; Ratnaningsih, Tri

2016-01-01

Gross motor skills on children must be optimized much earlier since it plays important role not only on their interaction process but also in supporting other multiple developments. One of the means in developing child's motor skill is by providing innovative games i.e. modified games including game format, game timing, and game sequence. The…

Characterization of natural and modified clay for development of polymers nanocomposites

International Nuclear Information System (INIS)

Jarek, Flavia; Reis, Dayane M.; Kloss, Juliana R.; Mauler, Raquel S.; Barbosa, Ronilson V.

2009-01-01

Bentonite is a technologic terminology applied to clays of very thin granulation basically composed by mineral of the esmectites group where the montmorilonite is the most common, meaning that it is a filossilicate with layers as thick as 1 nm. Because it is polar, the clay is not compatible with most of polymers that are less polars or apolars, reason why it has to be modified to improve compatibility between the inorganic (polar) and the organic phase (apolar). Aiming to show the potential for the development of nanocomposites, the purpose of this work was to verify the chemical and physical characteristics of the various bentonites by comparing the technical files and performing the water Foster swelling and change chemically the samples, evaluating them by infrared spectroscopy and X-ray diffractometry. The different analyzed samples of bentonite showed an effective intercalation of the modifying agent on the surface of the structure. This evidence will allow the use of this material in the clay-polymer nanocomposites synthesis. (author)

Wind-energy Science, Technology and Research (WindSTAR) Consortium: Curriculum, Workforce Development, and Education Plan Final Report

Energy Technology Data Exchange (ETDEWEB)

Manwell, James [Univ. of Massachusetts, Amherst, MA (United States)

2013-03-19

The purpose of the project is to modify and expand the current wind energy curriculum at the University of Massachusetts Amherst and to develop plans to expand the graduate program to a national scale. The expansion plans include the foundational steps to establish the American Academy of Wind Energy (AAWE). The AAWE is intended to be a cooperative organization of wind energy research, development, and deployment institutes and universities across North America, whose mission will be to develop and execute joint RD&D projects and to organize high-level science and education in wind energy

2010-11 Research Portfolio: Research & Development Division

Science.gov (United States)

Educational Testing Service, 2010

2010-01-01

This document describes the breadth of the research that the ETS (Educational Testing Service) Research & Development division is conducting in 2010. This portfolio will be updated in early 2011 to reflect changes to existing projects and new projects that were added after this document was completed. The research described in this portfolio falls…

Building human capacity through early childhood intervention: the Child Development Research Programme at the Tropical Medicine Research Institute, the University of the West Indies, Kingston, Jamaica.

Science.gov (United States)

Walker, S P; Chang, S M; Powell, C A; Baker-Henningham, H

2012-07-01

Research conducted by the Child Development Research Group in the Tropical Medicine Research Institute has made significant contributions to the understanding of the importance of early nutrition and the home environment for children's development and the impact of psychosocial stimulation for disadvantaged and/or undernourished children. The work has provided critical evidence that has contributed to the increasing attention given to early childhood development in the work and policies of agencies such as the World Bank, World Health Organization (WHO) and United Nations Children Fund (UNICEF). This review concerns research which documented the impact of malnutrition on children's development and for the first time demonstrated the benefits and necessity of psychosocial stimulation for improvement in development. Subsequent research was critical in establishing the importance of linear growth retardation (stunting) as a risk factor for poor child development. A twenty-two-year study of stunted children has demonstrated benefits through to adulthood in areas such as educational attainment, mental health and reduced violent behaviour from an early childhood home visiting programme that works through mothers to promote their children's development. The group's research has also demonstrated that it is feasible and effective to integrate the stimulation intervention into primary care services with benefits to children's development and mothers'child rearing knowledge and practices. The group is currently conducting a study to provide information needed for scaling-up of parenting programmes through evaluation of a new approach to improving parenting through health centres and a modified home visit programme.

Zeolites modified with silver for the development of a water disinfection system

International Nuclear Information System (INIS)

Aparicio V, S.

2013-01-01

In spite of great strides that have been taken in sanitation technologies, there still exist health problems due to microbiological contamination by water. The waterborne diseases have not been completely eradicated and are a big problem of economic interest and health. Moreover, the microbicidal properties of silver have been used for a long time. The use of silver as a disinfectant has many advantages; for example it inhibits a wide spectrum of microorganisms, it has oligo dynamic properties and owing its mechanisms of cell inactivation, it also does not allow the emergence of new resistant strains. In the present research, the kinetics of water disinfection with silver has been investigated, to develop small system for water disinfection, based in silver modified Mexican clinoptilolite. The chemical species of silver play a significant role in the disinfection processes. For this reason, in this work, were both the Ag + and nanoparticles of Ag ο considered. The synthesis of nanoparticles of Ag ο woes performed by thermal and chemical reduction. It was found that the chemical reduction of Ag + to Ag ο was more efficient because it presented more defined nano structures and better distribution than those of thermal reduction. Clinoptilolite of Taxco (Guerrero) was chosen to exchange the native ions from the clinoptilolite by Ag + from the aqueous medium, or to deposit the nanoparticles of Ag ο on this surface. These silver modified zeolitic materials were characterized by scanning electron microscopy (Sem), elemental analyses (EDS), X-ray diffraction (XRD) and neutron activation analysis (NAA). The results showed that the crystallographic structure of the clinoptilolite did not change during thermal and chemical reduction treatments of Ag + to obtain the nanoparticles of Ag ο . The bactericide activity of the silver modified zeolitic materials (with Ag + or nanoparticles of Ag ο ) was evaluated on Escherichia coli Atcc 8739, in both distilled water and well

Research and development and industrial informatization

International Nuclear Information System (INIS)

1995-08-01

This book deals with research and development and industrial informatization with development of technology international trend, the present conditions of scientific technology in the major nations, politics of technical development and trend, process of national research and development, research for industrial research and development, strengthen cooperation for scientific technology among nations, current situation and development of technology by field such as energy, software and system, and technology for industrial informatization.

Characteristics of Modified 9Cr-1Mo Steel for Reactor Pressure Vessel of Very High Temperature Gas Cooled Reactor

Energy Technology Data Exchange (ETDEWEB)

Kim, Sung Ho; Ryu, W. S.; Han, Chang Hee; Yoon, J. H.; Chang, Jong Hwa

2004-11-15

Many researches and developments have been progressed for the construction of VHTR by 2020 in Korea. Modified 9Cr-1Mo steel has been receiving attention for the application to the reactor pressure vessel material of VHTR. We collected and analyzed the research data for modified 9Cr-1Mo steel in order to understand the characteristics of modified 9Cr-1Mo steel. The modified 9Cr-1Mo steel is a modified alloy system similar to conventional 9Cr-1Mo grade ferritic steel. Modifications include additions of vanadium, niobium, and nitrogen, as well as lower carbon content. In this report, we summarized the change of microstructure and mechanical properties after tempering, thermal aging, and irradiation. Modified 9Cr-1Mo steel has high strength and thermal conductivity, low thermal expansion, and good resistance to corrosion. But the irradiation embrittlement behavior of modified 9Cr-1Mo steel should be evaluated and the evaluation methodology also should be developed. At the same time, the characteristics of weldment which is the weak part in pressure vessel should be evaluated.

Genetically Modified Crops: Towards Agricultural Growth, Agricultural Development, or Agricultural Sustainability?

OpenAIRE

Azadi, Hossein; Ghanian, Mansour; Ghuchani, Omid M.; Rafiaani, Parisa; Taning, Clauvis N. T.; Hajivand, Roghaye Y.; Dogot, Thomas

2015-01-01

The present debate on how to increase global food production in a sustainable way has focused on arguments over the pros and cons of genetically modified (GM) crops. Scientists in both public and private sectors clearly regard GM technology as a major new set of tools, whereas industry sees it as an opportunity for increased profits. However, it remains questionable whether GM crops can contribute to agricultural growth, agricultural development, and agricultural sustainability. This review p...

Development of modified release diltiazem HCl tablets using composite index to identify optimal formulation.

Science.gov (United States)

Gohel, M C; Patel, M M; Amin, A F

2003-05-01

This article reports the preparation of tartaric acid treated ispaghula husk powder for the development of modified release tablets of diltiazem HCl by adopting direct compression technique and a 32 full factorial design. The modified ispaghula husk powder showed superior swelling and gelling as compared to untreated powder. Addition of compaction augmenting agent such as dicalcium phosphate was found to be essential for obtaining tablets with adequate crushing strength. In order to improve the crushing strength of diltiazem HCl tablets, to modulate drug release pattern, and to obtain similarity of dissolution profiles in distilled water and simulated gastric fluid (pH 1.2), modified guar gum was used along with modified ispaghula husk powder and tartaric acid. A novel composite index, which considers a positive or a negative deviation from an ideal value, was calculated considering percentage drug release in 60, 300, and 540 min as dependent variables for the selection of a most appropriate batch. Polynomial equation and contour plots are presented. The concept of similarity factor (f2) was used to prove similarity of dissolution in water and simulated gastric fluid (pH 1.2).

Development of an active behavioural physiotherapy intervention (ABPI) for acute whiplash-associated disorder (WAD) II management: a modified Delphi study.

Science.gov (United States)

Wiangkham, Taweewat; Duda, Joan; Haque, M Sayeed; Rushton, Alison

2016-09-14

To develop an active behavioural physiotherapy intervention (ABPI) for managing acute whiplash-associated disorder (WAD) II using a modified Delphi method to develop consensus for the basic features of the ABPI. Modified Delphi study. Our systematic review and meta-analysis evaluating conservative management for acute WADII found that a combined ABPI may be a useful intervention to prevent patients progressing to chronicity. No previous research has considered a combined behavioural approach and active physiotherapy in the management of acute WADII patients. The ABPI was therefore developed using a rigorous consensus method using international research and local clinical whiplash experts. Descriptive statistics were used to assess consensus in each round. Online international survey. A purposive sample of 97 potential participants (aiming to recruit n=30) consisting of international research whiplash experts, UK private physiotherapists and UK postgraduate musculoskeletal physiotherapy students were invited to participate via electronic mail with an attached participant information sheet and consent form. 36 individuals signed and returned the consent form. In round 1, 32/36 participants (response rate=89%, mean age±SD=36.03±13.22 years) across 8 countries (Australia, Finland, Greece, India, Netherlands, Norway, Sweden and UK) contributed to round 1 questionnaire. Response rates were 78% and 75% for rounds 2 and 3, respectively. Following round 3, 12 underlying principles (eg, return to normal function as soon as possible, pain management, encouragement of self-management, reduce fear avoidance and anxiety) achieved consensus. The treatment components reaching consensus included behavioural (eg, education, reassurance, self-management) and physiotherapy components (eg, exercises for stability and mobility). No passive intervention achieved consensus. Experts suggested and agreed the underlying principles and treatment components of the ABPI for the management

7 CFR 917.39 - Production research, market research and development.

Science.gov (United States)

2010-01-01

... establish or provide for the establishment of production research, marketing research, and development... 7 Agriculture 8 2010-01-01 2010-01-01 false Production research, market research and development...) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF...

New Development in NASA's Rodent Research Hardware for Conducting Long Duration Biomedical and Basic Research in Space

Science.gov (United States)

Shirazi-Fard, Y.; Choi, S.; Harris, C.; Gong, C.; Beegle, J. E.; Stube, K. C.; Martin, K. J.; Nevitt, R. G.; Globus, R. G.

2017-01-01

Animal models, particularly rodents, are the foundation of pre-clinical research to understand human diseases and evaluate new therapeutics, and play a key role in advancing biomedical discoveries both on Earth and in space. The National Research Councils Decadal survey emphasized the importance of expanding NASAs life sciences research to perform long duration, rodent experiments on the International Space Station (ISS). To accomplish this objective, flight hardware, operations, and science capabilities were developed at NASA Ames Research Center (ARC) to enhance science return for both commercial (CASIS) and government-sponsored rodent research. The Rodent Research program at NASA ARC has pioneered a new research capability on the International Space Station and has progressed toward translating research to the ISS utilizing commercial rockets, collaborating with academia and science industry, while training crewmembers to assist in performing research on orbit. Throughout phases of these missions, our practices, hardware and operations have evolved from tested to developed standards, and we are able to modify and customize our procedure and operations for mission specific requirements. The Rodent Research Habitat is capable of providing a living environment for animals on ISS according to standard animal welfare requirements. Using the cameras in the Habitat, the Rodent Research team has the ability to perform daily health checks on animals, and further analyze the collected videos for behavioral studies. A recent development of the Rodent Research hardware is inclusion of enrichment, to provide the animals the ability to rest and huddle. The Enrichment Hut is designed carefully for adult mice (up to 35 week old) within animal welfare, engineering, and operations constraints. The Hut is made out of the same stainless steel mesh as the cage interior, it has an ingress and an egress to allow animals move freely, and a hinge door to allow crewmembers remove the

MARKETING RESEARCH OF ATTITUDES TOWARDS GENETICALLY MODIFIED CROPS BY GEORGIAN FARMERS

Directory of Open Access Journals (Sweden)

NUGZAR TODUA

2017-02-01

Full Text Available Although, genetically modified (GM crops have to be a broadly debated topic in different countries, there has been much less attention devoted to farmer attitudes towards GM crops. This paper attempts to research farmers’ insights on GM crops in Georgia through February-March 2014. An in-depth survey of 611 farmers revealed that respondents lack sufficient knowledge about genetic engineering. They tend to have a negative attitude towards GM crops and are strongly against of import and adoption of GM seeds. An empirical examination based on analysis of variance and Pearson’s correlation coefficient verified that both education and age were significant determinants of awareness of farmers about genetically engineered crops, while income used to have no significant influence on the farmers’ decision to adopt GM crops. In addition, relationship between awareness about genetic engineering and farmers’ decision to adopt GM crops has to be insignificant, as well.

Modifiers of radiation response in tumor therapy: strategies and expectations

International Nuclear Information System (INIS)

Elkind, M.M.

1982-01-01

The administration of two (or more) cytotoxic agents to widen the differential between the responses of tumor and normal tissues depends upon the biological properties of the agents in the cells and tissues, their interactive potential, and the strategy employed in their administration. Assuming that one agent is ionizing radiation, and considering response modification in broad terms, the qualitative features of various strategies are developed for physical as well as chemical modifies. The heterogeneity of human tumor cells and the compensatory mechanisms of normal tissues following injury are identified as topical areas requiring sustained research effort. Finally, estimates are developed for the degree of improvement required from a response modifier to effect significant improvements in tumor cure rates

Modifiers of radiation response in tumor therapy: strategies and expectations

International Nuclear Information System (INIS)

Elkind, M.M.

1982-01-01

The administration of two (or more) cytotoxic agents to widen the differential between the responses of tumor and normal tissues depends upon the biological properties of the agents in the cells and tissues, their interactive potential, and the strategy employed in their administration. Assuming that one agent is ionizing radiation, and considering response modification in broad terms, the qualitative features of various strategies are developed for physical as well as chemical modifiers. The heterogeneity of human tumor cells and the compensatory mechanisms of normal tissues following injury are identified as topical areas requiring sustained research effort. Finally, estimates are developed for the degree of improvement from a response modifier to effect significant improvements in tumor cure rates

Modifiable risk factors for schizophrenia and autism--shared risk factors impacting on brain development.

Science.gov (United States)

Hamlyn, Jess; Duhig, Michael; McGrath, John; Scott, James

2013-05-01

Schizophrenia and autism are two poorly understood clinical syndromes that differ in age of onset and clinical profile. However, recent genetic and epidemiological research suggests that these two neurodevelopmental disorders share certain risk factors. The aims of this review are to describe modifiable risk factors that have been identified in both disorders, and, where available, collate salient systematic reviews and meta-analyses that have examined shared risk factors. Based on searches of Medline, Embase and PsycINFO, inspection of review articles and expert opinion, we first compiled a set of candidate modifiable risk factors associated with autism. Where available, we next collated systematic-reviews (with or without meta-analyses) related to modifiable risk factors associated with both autism and schizophrenia. We identified three modifiable risk factors that have been examined in systematic reviews for both autism and schizophrenia. Advanced paternal age was reported as a risk factor for schizophrenia in a single meta-analysis and as a risk factor in two meta-analyses for autism. With respect to pregnancy and birth complications, for autism one meta-analysis identified maternal diabetes and bleeding during pregnancy as risks factors for autism whilst a meta-analysis of eight studies identified obstetric complications as a risk factor for schizophrenia. Migrant status was identified as a risk factor for both autism and schizophrenia. Two separate meta-analyses were identified for each disorder. Despite distinct clinical phenotypes, the evidence suggests that at least some non-genetic risk factors are shared between these two syndromes. In particular, exposure to drugs, nutritional excesses or deficiencies and infectious agents lend themselves to public health interventions. Studies are now needed to quantify any increase in risk of either autism or schizophrenia that is associated with these modifiable environmental factors. Copyright © 2012 Elsevier Inc

siRNAmod: A database of experimentally validated chemically modified siRNAs.

Science.gov (United States)

Dar, Showkat Ahmad; Thakur, Anamika; Qureshi, Abid; Kumar, Manoj

2016-01-28

Small interfering RNA (siRNA) technology has vast potential for functional genomics and development of therapeutics. However, it faces many obstacles predominantly instability of siRNAs due to nuclease digestion and subsequently biologically short half-life. Chemical modifications in siRNAs provide means to overcome these shortcomings and improve their stability and potency. Despite enormous utility bioinformatics resource of these chemically modified siRNAs (cm-siRNAs) is lacking. Therefore, we have developed siRNAmod, a specialized databank for chemically modified siRNAs. Currently, our repository contains a total of 4894 chemically modified-siRNA sequences, comprising 128 unique chemical modifications on different positions with various permutations and combinations. It incorporates important information on siRNA sequence, chemical modification, their number and respective position, structure, simplified molecular input line entry system canonical (SMILES), efficacy of modified siRNA, target gene, cell line, experimental methods, reference etc. It is developed and hosted using Linux Apache MySQL PHP (LAMP) software bundle. Standard user-friendly browse, search facility and analysis tools are also integrated. It would assist in understanding the effect of chemical modifications and further development of stable and efficacious siRNAs for research as well as therapeutics. siRNAmod is freely available at: http://crdd.osdd.net/servers/sirnamod.

Research and development on materials, structural strength and seismic integrity of FBR components

International Nuclear Information System (INIS)

Sumikawa, Masaharu; Kirihara, Seishin; Shigeta, Masayuki; Shimoyashiki, Shigehiro; Nishioka, Akio.

1982-01-01

For designing high temperature structures of FBRs, highly reliable design is required on the basis of safety requirement. At the same time, it is necessary to guarantee the soundness of structures over the total design life of plants. Since the high temperature equipments are operated in a creep temperature region and show nonlinear behaviour, nonlinear structural analysis is required. Hitachi Ltd., based on the concept of verifying the latest technology to reflect it to the design along with its adoption, has progressed various research and development by organizing a project team collecting specialists in the company, independently developing and modifying the nonlinear structural analysis and evaluation program, and establishing the organization through the introduction of a general purpose large scale computer. The research and development for materials include the development of the strength standards for high temperature structural materials and the improvement of the high temperature characteristics of JIS stainless steel SUS 321. In the R and D for high temperature strength, the test on the deforming behaviour of plates due to bending creep, the thermal shock test for steam generator tube plates and others were performed. In the R and D for seismic integrity, the vibration test of piping support structure and the development of detailed seismic property evaluation program are mentioned. (Wakatsuki, Y.)

Development of a novel electric field-assisted modified hydrodynamic cavitation system for disintegration of waste activated sludge.

Science.gov (United States)

Jung, Kyung-Won; Hwang, Min-Jin; Yun, Yeo-Myeong; Cha, Min-Jung; Ahn, Kyu-Hong

2014-09-01

In this current study, we present a modified hydrodynamic cavitation device that combines an electric field to substitute for the chemical addition. A modified HC system is basically an orifice plate and crisscross pipe assembly, in which the crisscross pipe imparts some turbulence, which creates collision events. This study shows that for maximizing disintegration, combining HC system, which called electric field-assisted modified orifice plate hydrodynamic cavitation (EFM-HC) in this study, with an electric field is important. Various HC systems were compared in terms of disintegration of WAS, and, among them, the EFM-HC system exhibited the best performance with the highest disintegration efficiency of 47.0±2.0% as well as the destruction of WAS morphological characteristics. The experimental results clearly show that a conventional HC system was successfully modified. In addition, electric field has a great potential for efficient disintegration of WAS for as a additional option in a combination treatment. This study suggests continued research in this field may lead to an appropriate design for commercial use. Copyright © 2014 Elsevier B.V. All rights reserved.

Development of a modified dry curing process for beef.

Science.gov (United States)

Hayes, J E; Kenny, T A; Ward, P; Kerry, J P

2007-11-01

The development of a dry curing process using physical treatments to promote the diffusion of the cure ingredients was studied. Vacuum pulsing with and without tumbling, continuous vacuum, and tumbling only treatments were compared with a conventional static dry cure control method on beef M. supraspinatus. Vacuum tumble and tumble only treatments gave highest core salt content after 7 days conditioning (3.3% and 3.1%, respectively). All test treatments resulted in higher colour uniformity and lower % cook loss in comparison to control (PCured beef slices were stored in modified atmosphere packs (MAP) (80%N(2):20%CO(2)) for up to 28 day at 4°C. Redness (a(∗), Pcured beef products with enhanced organoleptic quality and increased yields.

Research on preparation of phosphate-modified animal glue binder for foundry use

Science.gov (United States)

Wang, Tian-Shu; Liu, Wei-Hua; Li, Ying-Min

2018-03-01

In this paper, three phosphates were used as modifiers to modify animal glue binder. The structural characteristics and thermal properties of animal glue binder treated with phosphates were studied by Fourier transform-infrared spectroscopy, gel permeation chromatography and derivative thermogravimetric analysis. The results showed that the modified animal glue binder had better sand tensile strength and lower viscosity than untreated animal glue binder. The best modification process was as follows: the optimal amount of sodium carbonate was 4 wt% to animal glue; the optimal weight ratio of the modifiers was sodium pyrophosphate : sodium tripolyphosphate : sodium hexametaphosphate : animal glue = 3 : 3 : 4 : 100, and the optimal reaction should be performed at 80°C for a reaction time of 120 min. A final tensile strength of approximately 3.20 MPa was achieved and the viscosity value was approximately 880 mPa s.

Development and Evaluation of Event-Specific Quantitative PCR Method for Genetically Modified Soybean MON87701.

Science.gov (United States)

Tsukahara, Keita; Takabatake, Reona; Masubuchi, Tomoko; Futo, Satoshi; Minegishi, Yasutaka; Noguchi, Akio; Kondo, Kazunari; Nishimaki-Mogami, Tomoko; Kurashima, Takeyo; Mano, Junichi; Kitta, Kazumi

2016-01-01

A real-time PCR-based analytical method was developed for the event-specific quantification of a genetically modified (GM) soybean event, MON87701. First, a standard plasmid for MON87701 quantification was constructed. The conversion factor (C f ) required to calculate the amount of genetically modified organism (GMO) was experimentally determined for a real-time PCR instrument. The determined C f for the real-time PCR instrument was 1.24. For the evaluation of the developed method, a blind test was carried out in an inter-laboratory trial. The trueness and precision were evaluated as the bias and reproducibility of relative standard deviation (RSDr), respectively. The determined biases and the RSDr values were less than 30 and 13%, respectively, at all evaluated concentrations. The limit of quantitation of the method was 0.5%, and the developed method would thus be applicable for practical analyses for the detection and quantification of MON87701.

Development of stress-modified fracture strain criterion for ductile fracture of API X65 steel

International Nuclear Information System (INIS)

Oh, Chang Kyun; Kim, Yun Jae; Park, Jin Moo; Kim, Woo Sik; Baek, Jong Hyun

2005-01-01

This paper presents a stress-modified fracture strain for API X65 steel used for gas pipeline, as a function of stress triaxiality. To determine the stress-modified fracture strain, tension test of bars with four different notch radii, made of API X65 steel, is firstly performed, from which true fracture strains are determined as a function of notch radius. Then detailed elastic-plastic, large strain Finite Element (FE) analyses are performed to estimate variations of stress triaxiality in the notched bars with load. Combining experimental with FE results provides the true fracture strain as a function of stress triaxiality, which is regarded as a criterion of ductile fracture. Application of the developed stress-modified fracture strain to failure prediction of gas pipes made of API X65 steel with various types of defects is discussed

Research and development toward Monju

International Nuclear Information System (INIS)

Nakamoto, Koichiro; Ikegami, Tetsuo; Sikakura, Sakae; Iwata, Koji; Yamaguchi, Katsuhisa; Kodaira, Kiyoshi

1994-01-01

Power Reactor and Nuclear Fuel Development Corporation aimed at the development of the experimental FBR ''Joyo'' and the prototype FBR ''Monju'', and has promoted the research and development of respective fields of reactor physics, shielding, fuel, safety, sodium technology, machinery and equipment, structural materials, measurement and control by cooperating with Japan Atomic Energy Research Institute, universities, national and public research institutes, electric power and manufacturing companies. Also the promotion of the development by international cooperation has been carried out positively. As for the core and fuel, the Japan-UK joint research ''MOZART project'' for the increase of reactor power output and the heightening of fuel burnup, and the test of MOX fuel, as for machinery, equipment and structure, the rationalization of structural design, the development of steam generator, the test with sodium testing facility, and as for safety, the test on the events related to the core, decay heat removing system and containment system were carried out. (K.I.)

Research and Development. Annual Report 2000

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-07-01

This report discusses the research and development activities in which NVE has been involved in 2000. These activities fall into three categories: watercourse research, hydrological research and energy related research. The HYDRA research programme, which studied flooding and human intervention, is discussed in particular. The report includes a list of research and development reports that were published in 2000.

Development of research reactor simulator and its application to dynamic test-bed

International Nuclear Information System (INIS)

Kwon, Kee-Choon; Baang, Dane; Park, Jae-Chang; Lee, Seung-Wook; Bae, Sung Won

2014-01-01

We developed a real-time simulator for 'High-flux Advanced Neutron Application ReactOr (HANARO), and the Jordan Research and Training Reactor (JRTR). The main purpose of this simulator is operator training, but we modified this simulator into a dynamic test-bed (DTB) to test the functions and dynamic control performance of reactor regulating system (RRS) in HANARO or JRTR before installation. The simulator hardware consists of a host computer, 6 operator stations, a network switch, and a large display panel. The software includes a mathematical model that implements plant dynamics in real-time, an instructor station module that manages user instructions, and a human machine interface module. The developed research reactor simulators are installed in the Korea Atomic Energy Research Institute nuclear training center for reactor operator training. To use the simulator as a dynamic test-bed, the reactor regulating system modeling software of the simulator was replaced by actual RRS cabinet, and was interfaced using a hard-wired and network-based interface. RRS cabinet generates control signals for reactor power control based on the various feedback signals from DTB, and the DTB runs plant dynamics based on the RRS control signals. Thus the Hardware-In-the-Loop Simulation between RRS and the emulated plant (DTB) has been implemented and tested in this configuration. The test result shows that the developed DTB and actual RRS cabinet works together simultaneously resulting in quite good dynamic control performances. (author)

The development of polyurethane modified bitumen emulsions for cold mix applications

OpenAIRE

Carrera Páez, Virginia; Cuadri Vega, Antonio Abad; García Morales, Moisés; Partal López, Pedro

2015-01-01

Bitumen emulsions stand for an alternative paving practice to the traditional hot-mix asphalts. In addition, modified bitumen emulsions show a better performance than unmodified ones. This work studies the feasibility of obtaining polyurethane modified bitumen emulsions, in which an isocyanate-functionalized polyol constitutes the bitumen modifier (in varying concentration from 1 to 4 wt.%). Storage stability and high in-service performance are evaluated by means of evolution of droplet size ...

Advances in research and development homojunction and quantum-well infrared detectors

CERN Document Server

Francombe, Maurice H

1995-01-01

Physics of Thin Films is one of the longest running continuing series in thin film science, consisting of twenty volumes since 1963. The series contains quality studies of the properties of various thinfilms materials and systems.In order to be able to reflect the development of today''s science and to cover all modern aspects of thin films, the series, starting with Volume 20, has moved beyond the basic physics of thin films. It now addresses the most important aspects of both inorganic and organic thin films, in both their theoretical as well as technological aspects. Therefore, in order to reflect the modern technology-oriented problems, the title has been slightly modified from Physics of Thin Films to Thin Films.Key Features* Discusses the latest research about structure, physics, and infrared photoemissive behavior of heavily doped silicon homojunctions and Ge and GaAs-based alloy junctions* Reviews the current status of SiGe/Si quantum wells for infrared detection* Discusses key developments in the gro...

Development of Surveillance and In-Service Inspection Programme for Indian Research Reactors Cirus and Dhruva

International Nuclear Information System (INIS)

Shukla, D.K.

2006-01-01

Many safety requirements for research reactors are quite similar to those of power reactors. For research reactors with a higher hazard potential, the use of safety codes and guides for power reactors is more appropriate. However, there are many important differences between power reactors and research reactors that must be taken into account to ensure that adequate safety margins are available in design and operation of the research reactor. Most research reactors may have small potential for hazard to the public compared to power reactors but may pose a greater potential hazard to the plant operators. The need for greater flexibility in use of research reactors for individual experiments requires a different safety approach. Safety rules for power reactors are required to be substantially modified for application to specific research reactor. Following the intent of the available safety guides for surveillance and In-Service Inspection of Nuclear Power Plants, guidelines were formulated to develop surveillance and In-Service Inspection programme for research reactors Cirus and Dhruva. Based on the specific design of these research reactors, regulatory requirements, the degree of sophistication and experience of the technical organization involved in operating the research reactor, guidelines were evolved for developing and implementing the surveillance and In-Service Inspection programme for research reactors Cirus (40 MWt) and Dhruva (100 MWt) located at Bhabha Atomic Research Centre, Trombay, Mumbai, India. Paper describes the approach adopted for formulation of surveillance and In-service Inspection programme for Dhruva reactor in detail. (author)

Canada Research Chairs | IDRC - International Development ...

International Development Research Centre (IDRC) Digital Library (Canada)

aspx. International Research Chairs Initiative. The International Research Chairs Initiative pairs top research talent from universities in Canada with their counterparts in developing countries to address key development challenges. View more

Determining the Walker exponent and developing a modified Smith-Watson-Topper parameter model

Energy Technology Data Exchange (ETDEWEB)

Lv, Zhiqiang; Huang, Hong Zhong; Wang, Hai Kun; Gao, Huiying; Zuo, Fang Jun [University of Electronic Science and Technology of China, Chengdu (China)

2016-03-15

Mean stress effects significantly influence the fatigue life of components. In general, tensile mean stresses are known to reduce the fatigue life of components, whereas compressive mean stresses are known to increase it. To date, various methods that account for mean stress effects have been studied. In this research, considering the high accuracy of mean stress correction and the difficulty in obtaining the material parameter of the Walker method, a practical method is proposed to describe the material parameter of this method. The test data of various materials are then used to verify the proposed practical method. Furthermore, by applying the Walker material parameter and the Smith-Watson-Topper (SWT) parameter, a modified strain-life model is developed to consider sensitivity to mean stress of materials. In addition, three sets of experimental fatigue data from super alloy GH4133, aluminum alloy 7075-T651, and carbon steel are used to estimate the accuracy of the proposed model. A comparison is also made between the SWT parameter method and the proposed strainlife model. The proposed strain-life model provides more accurate life prediction results than the SWT parameter method.

Photovoltaic research and development

CSIR Research Space (South Africa)

Cummings, F

2009-09-01

Full Text Available Photovoltaic (PV) is the direct conversion of sunlight into electrical energy through a solar cell. This presentation consists of an introduction to photovoltaics, the South African PV research roadmap, a look at the CSIR PV research and development...

Development of road soil cement compositions modified with complex additive based on polycarboxylic ether

Science.gov (United States)

Bulanov, P. E.; Vdovin, E. A.; Mavliev, L. F.; Kuznetsov, D. A.

2018-03-01

The paper is focused on the research results of the main physical and technical properties of the cement-stabilized polymineral clay modified with a complex hydrophobic plasticizer based on polycarboxylate and octyltriethoxysilane ethers. A graphical result interpretation of the mathematic model which shows the influence of the complex hydrophobic plasticizer components on the cement-stabilized polymineral clay, containing more than 85% of relict minerals, has been designed. The research significance for the building sector lies in the fact that applying a complex hydrophobic plasticizer provides increasing the compressive strength of the cement-stabilized polymineral clay up to 102%, the tensile bending strength – up to 88%, the freeze-thaw resistance – up to 114%.

Research and development of CRIEPI

International Nuclear Information System (INIS)

Akita, Shirabe

2008-01-01

Central Research Institute of Electric Power Industry (CRIEPI) reported its R and D of nuclear power technologies. The research results of light water reactor aging deterioration contain the estimation method of irradiation embrittlement of pressure vessel, stress corrosion cracking of piping and core internal structure, and pipe thinning. The backend project support researches include transpiration and storage of recycle fuel, the high-level radioactive waste disposal and low-level radioactive waste disposal. Safety of concrete cask storage was confirmed by the falling test, SCC test and vibration test. The researches for the next generation nuclear technologies have developed the pyrochemical reprocessing process for the metal fuel and oxide fuel, and development of metal fuel with U, Pu and Zr. Assist management of development of fast reactor is proceeding. One of researches of radiation safety is on low dose X-ray bystander effect on the diabetes mellitus of model mouse. (S.Y.)

[The trend of developing new disease-modifying drugs in Alzheimer's disease].

Science.gov (United States)

Arai, Hiroyuki; Furukawa, Katsutoshi; Tomita, Naoki; Ishiki, Aiko; Okamura, Nobuyuki; Kudo, Yukitsuka

2016-03-01

Development of symptomatic treatment of Alzheimer s disease by cholinesterase inhibitors like donepezil was successful. However, it is a disappointment that development of disease-modifying drugs such as anti-amyloid drug based on amyloid-cascade theory has been interrupted or unsuccessful. Therefore, we have to be more cautious regarding inclusion criteria for clinical trials of new drugs. We agree that potentially curative drugs should be started before symptoms begin as a preemptive therapy or prevention trial. The concept of personalized medicine also is important when ApoE4-related amyloid reducing therapy is considered. Unfortunately, Japanese-ADNI has suffered a setback since 2014. However, Ministry of Health, Labour and Welfare gave a final remark that there was nothing wrong in the data managing process in the J-ADNI data center. We should pay more attention to worldwide challenges of speeding up new drug development.

Development of International Terminology and Definitions for Texture-Modified Foods and Thickened Fluids Used in Dysphagia Management: The IDDSI Framework.

Science.gov (United States)

Cichero, Julie A Y; Lam, Peter; Steele, Catriona M; Hanson, Ben; Chen, Jianshe; Dantas, Roberto O; Duivestein, Janice; Kayashita, Jun; Lecko, Caroline; Murray, Joseph; Pillay, Mershen; Riquelme, Luis; Stanschus, Soenke

2017-04-01

Dysphagia is estimated to affect ~8% of the world's population (~590 million people). Texture-modified foods and thickened drinks are commonly used to reduce the risks of choking and aspiration. The International Dysphagia Diet Standardisation Initiative (IDDSI) was founded with the goal of developing globally standardized terminology and definitions for texture-modified foods and liquids applicable to individuals with dysphagia of all ages, in all care settings, and all cultures. A multi-professional volunteer committee developed a dysphagia diet framework through systematic review and stakeholder consultation. First, a survey of existing national terminologies and current practice was conducted, receiving 2050 responses from 33 countries. Respondents included individuals with dysphagia; their caregivers; organizations supporting individuals with dysphagia; healthcare professionals; food service providers; researchers; and industry. The results revealed common use of 3-4 levels of food texture (54 different names) and ≥3 levels of liquid thickness (27 different names). Substantial support was expressed for international standardization. Next, a systematic review regarding the impact of food texture and liquid consistency on swallowing was completed. A meeting was then convened to review data from previous phases, and develop a draft framework. A further international stakeholder survey sought feedback to guide framework refinement; 3190 responses were received from 57 countries. The IDDSI Framework (released in November, 2015) involves a continuum of 8 levels (0-7) identified by numbers, text labels, color codes, definitions, and measurement methods. The IDDSI Framework is recommended for implementation throughout the world.

Research on water permeability of poly(ethylene) terephthalate track membranes modified with plasma

International Nuclear Information System (INIS)

Kravets, L.I.; Dmitriev, S.N.; Sleptsov, V.V.; Elinson, V.M.; Potryasay, V.V.

2001-01-01

The properties of poly(ethylene) terephthalate track membranes subjected to effect of plasma of the RF-discharge in air have been investigated. The influence conditions of a plasma treatment on the surface properties and hydrodynamic characteristics of the membranes has been studied. It has been found that the effect of the air plasma on the researched membranes results in a formation of asymmetric track membranes with a higher flow rate, the structure and chemical composition of their superficial layer are changed. It was shown that the availability of the modified layer on the membrane surface caused changing in their hydrodynamic characteristics - the water permeability of the membranes, processed in plasma, in a greater degree depends upon pH of a filtered solution. (author)

Modifiable risk factors for prescription medicine sharing behaviours.

Science.gov (United States)

Beyene, Kebede; Aspden, Trudi; McNeill, Rob; Sheridan, Janie

2018-04-06

Prescription medicine sharing has been defined as giving one's own medicine to someone else (lending) or taking someone else's medicine (borrowing). Medicines can be shared for non-medical purposes (recreational sharing or drug abuse) or for their intended therapeutic benefits (non-recreational sharing, e.g. sharing antibiotics to self-treat); the latter is the focus of this research. Limited research evidence is available about modifiable risk factors for non-recreational medicine sharing and addressing this issue was the main aim of this research. An online, cross-sectional survey design was used. The study population comprised a convenience sample of 233 adults, who were primarily recruited through patient support groups across New Zealand. Principal component analysis was used to develop scales assessing attitudes toward medicine lending and borrowing. Logistic regression was used to examine the relationship between explanatory (demographics, medical conditions, and attitudes towards medicine sharing) and outcome (medicine sharing behaviours) variables. Half of the study participants reported ever borrowing/lending medicines, and approximately a third of participants reported borrowing/lending in the past year. Modifiable risk factors associated with an increased risk of medicine borrowing behaviour were having more difficulty with accessing medicine ('access-related issue'), stronger 'emotional beliefs about borrowing', and greater 'concern about missing doses.' Greater 'concern for the wellbeing of others' and stronger 'beliefs about the benefits and safety of lending' were associated with an increased risk of medicine lending behaviour. Those with a higher 'perceived risk of harm' were less likely to borrow or lend medicines. This research expands the current knowledge of medicine sharing by examining underlying behavioural factors which predict sharing behaviours and that can be modified by interventions. This research suggests using multifaceted

Research Article Special Issue

African Journals Online (AJOL)

pc

2017-11-10

Nov 10, 2017 ... The developed systems are able to enhance infection control, ... Some of researcher choose one data mining technique but modify the algorithm to fit with ... neural networks, decision trees, instance based learning, etc.

Modified cementless total coxofemoral prosthesis: development, implantation and clinical evaluation

Directory of Open Access Journals (Sweden)

S.A. Arias

2013-12-01

Full Text Available The aim of this study was to modify canine coxofemoral prostheses and the clinical evaluation of the implantation. Fifteen canine hips and femora of cadavers were used in order to study the surface points of modification in prostheses and develop a perforation guide. Femoral stems and acetabular components were perforated and coated with biphasic calcium phosphate layer. Twelve young adult male mongrel dogs were implanted with coxofemoral prostheses. Six were operated upon and implanted with cemented canine modular hip prostheses, establishing the control group. The remaining six were implanted with a novel design of cementless porous tricalcic phosphate-hydroxyapatite coated hip prostheses. Clinical and orthopedic performance, complications, and thigh muscular hypotrophy were assessed up to the 120th post-operatory day. After 120 days, animals with cementless prostheses had similar clinical and orthopedic performance compared to the cemented group despite the increased pain thigh hypotrophy. Animals that underwent cementless hip prosthesis evidenced more pain, compared to animals with cemented hip prosthesis that required longer recuperation time. No luxations, two fractures and two isquiatic neurapraxies were identified in the course of the study. Using both the cemented and the bioactive coated cementless model were suitable to dogs, showing clinical satisfactory results. Osseointegration and biological fixation were observed in the animals with the modified cementless hip prosthesis.

Current research and development at the Nuclear Research Center Karlsruhe

International Nuclear Information System (INIS)

Kuesters, H.

1982-01-01

The Nuclear Research Center Karlsruhe (KfK) is funded to 90% by the Federal Republic of Germany and to 10% by the State of Baden-Wuerttemberg. Since its foundation in 1956 the main objective of the Center is research and development (R and D) in the aera of the nuclear technology and about 2/3 of the research capacity is now devoted to this field. Since 1960 a major activity of KfK is R and D work for the design of fast breeder reactors, including material research, physics, and safety investigations; a prototype of 300 MWe is under construction now in the lower Rhine Valley. For enrichment of 235 U fissile material KfK developed the separation nozzle process; its technical application is realized within an international contract between the Federal Republic of Germany and Brazil. Within the frame of the European Programme on fusion technology KfK develops and tests superconducting magnets for toroidal fusion systems; a smaller activity deals with research on inertial confinement fusion. A broad research programme is carried through for safety investigations of nuclear installations, especially for PWRs; this activity is supplemented by research and development in the field of nuclear materials' safeguards. Development of fast reactors has to initiate research for the reprocessing of spent fuel and waste disposal. In the pilot plant WAK spent fuel from LKWs is reprocessed; research especially tries e.g. to improve the PUREX-process by electrochemical means, vitrification of high active waste is another main activity. First studies are being performed now to clarify the necessary development for reprocessing fast reactor fuel. About 1/3 of the research capacity of KfK deals with fundamental research in nuclear physics, solid state physics, biology and studies on the impact of technology on environment. Promising new technologies as e.g. the replacement of gasoline by hydrogen cells as vehicle propulsion are investigated. (orig.)

Provincial resource development research policy

Energy Technology Data Exchange (ETDEWEB)

Flock, D L

1976-01-01

In Alberta, there is an abundance of oil, natural gas, and coal. But only a small portion of the Alberta oil sands and coal resources are commercially accessible to surface-mining techniques. It is quite apparent that some in-situ technological breakthrough will be required, which will mean a concerted research effort at the provincial level. It is the purpose of this paper to present certain concepts and recommendations for a coordinated provincial resource development research policy for the Province of Alberta. Research as discussed in this paper covers basic and applied research and development. (MCW)

Institutional research and development, FY 1987

International Nuclear Information System (INIS)

Struble, G.L.; Lawler, G.M.; Crawford, R.B.; Kirvel, R.D.; Peck, T.M.; Prono, J.K.; Strack, B.S.

1987-01-01

The Institutional Research and Development program at Lawrence Livermore National Laboratory fosters exploratory work to advance science and technology, disciplinary research to develop innovative solutions to problems in various scientific fields, and long-term interdisciplinary research in support of defense and energy missions. This annual report describes research funded under this program for FY87

CTAB as a soft template for modified clay as filler in active packaging

Directory of Open Access Journals (Sweden)

Kajonpop Rittirong

2015-06-01

Full Text Available The role of modified clay has been employed in many areas of engineering research. Structure of clay was mainly focused on alumino-silicate layer and its form was presented as pillar layer. It composed of many ion exchanges inside. In industry, in order to use clay with higher efficiency, modification on surface and porosity has been developed. CTAB, one of the most effective cationic surfactant, was employed to modify the surface and porosity of clay.

Global research priorities for interpersonal violence prevention: a modified Delphi study.

Science.gov (United States)

Mikton, Christopher R; Tanaka, Masako; Tomlinson, Mark; Streiner, David L; Tonmyr, Lil; Lee, Bandy X; Fisher, Jane; Hegadoren, Kathy; Pim, Joam Evans; Wang, Shr-Jie Sharlenna; MacMillan, Harriet L

2017-01-01

To establish global research priorities for interpersonal violence prevention using a systematic approach. Research priorities were identified in a three-round process involving two surveys. In round 1, 95 global experts in violence prevention proposed research questions to be ranked in round 2. Questions were collated and organized according to the four-step public health approach to violence prevention. In round 2, 280 international experts ranked the importance of research in the four steps, and the various substeps, of the public health approach. In round 3, 131 international experts ranked the importance of detailed research questions on the public health step awarded the highest priority in round 2. In round 2, "developing, implementing and evaluating interventions" was the step of the public health approach awarded the highest priority for four of the six types of violence considered (i.e. child maltreatment, intimate partner violence, armed violence and sexual violence) but not for youth violence or elder abuse. In contrast, "scaling up interventions and evaluating their cost-effectiveness" was ranked lowest for all types of violence. In round 3, research into "developing, implementing and evaluating interventions" that addressed parenting or laws to regulate the use of firearms was awarded the highest priority. The key limitations of the study were response and attrition rates among survey respondents. However, these rates were in line with similar priority-setting exercises. These findings suggest it is premature to scale up violence prevention interventions. Developing and evaluating smaller-scale interventions should be the funding priority.

Institutional research and development, FY 1987

Energy Technology Data Exchange (ETDEWEB)

Struble, G.L.; Lawler, G.M.; Crawford, R.B.; Kirvel, R.D.; Peck, T.M.; Prono, J.K.; Strack, B.S. (eds.)

1987-01-01

The Institutional Research and Development program at Lawrence Livermore National Laboratory fosters exploratory work to advance science and technology, disciplinary research to develop innovative solutions to problems in various scientific fields, and long-term interdisciplinary research in support of defense and energy missions. This annual report describes research funded under this program for FY87. (DWL)

7 CFR 915.45 - Production research, marketing research and development.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Production research, marketing research and... Production research, marketing research and development. The committee may, with the approval of the Secretary, establish or provide for the establishment of production research, marketing research and...

Developing the Developers: Supporting and Researching the Learning of Professional Development Facilitators

Science.gov (United States)

Perry, Emily; Boylan, Mark

2018-01-01

Research on teacher professional development is extensive but there are fewer studies about the practitioners who facilitate professional development. Here we report on a pilot programme for professional development facilitators rooted in a cycle of action research. Informed by a categorisation of professional knowledge and skills of facilitators,…

Human Research Program Science Management: Overview of Research and Development Activities

Science.gov (United States)

Charles, John B.

2007-01-01

An overview of research and development activities of NASA's Human Research Science Management Program is presented. The topics include: 1) Human Research Program Goals; 2) Elements and Projects within HRP; 3) Development and Maintenance of Priorities; 4) Acquisition and Evaluation of Research and Technology Proposals; and 5) Annual Reviews

Fundamental research in developing countries

International Nuclear Information System (INIS)

Moravesik, M.J.

1964-01-01

Technical assistance is today a widespread activity. Large numbers of persons with special qualifications in the applied sciences go to the developing countries to work on specific research and development projects, as do educationists on Fulbright or other programmes - usually to teach elementary or intermediate courses. But I believe that until now it has been rare for a person primarily interested in fundamental research to go to one of these countries to help build up advanced education and pure research work. Having recently returned from such an assignment, and having found it a most stimulating and enlightening experience, I feel moved to urge strongly upon others who may be in a position to do so that they should seek similar experience themselves. The first step is to show that advanced education and fundamental research are badly needed in the under-developed countries.

Potential allergenicity research of Cry1C protein from genetically modified rice.

Science.gov (United States)

Cao, Sishuo; He, Xiaoyun; Xu, Wentao; Luo, Yunbo; Ran, Wenjun; Liang, Lixing; Dai, Yunqing; Huang, Kunlun

2012-07-01

With the development of genetically modified crops, there has been a growing interest in available approaches to assess the potential allergenicity of novel gene products. We were not sure whether Cry1C could induce allergy. We examined the protein with three other proteins to determine the potential allergenicity of Cry1C protein from genetically modified rice. Female Brown Norway (BN) rats received 0.1 mg peanut agglutinin (PNA), 1mg potato acid phosphatase (PAP), 1mg ovalbumin (OVA) or 5 mg purified Cry1C protein dissolved in 1 mL water by daily gavage for 42 days to test potential allergenicity. Ten days after the last gavage, rats were orally challenged with antigens, and physiologic and immunologic responses were studied. In contrast to sensitization with PNA, PAP and OVA Cry1C protein did not induce antigen-specific IgG2a in BN rats. Cytokine expression, serum IgE and histamine levels and the number of eosinophils and mast cells in the blood of Cry1C group rats were comparable to the control group rats, which were treated with water alone. As Cry1C did not show any allergenicity, we make the following conclusion that the protein could be safety used in rice or other plants. Copyright © 2012 Elsevier Inc. All rights reserved.

Mobility Research and Development (Briefing charts)

Science.gov (United States)

2016-03-17

Mobility Research & Development Dr. Paramsothy Jayakumar, STE, Analytics Tank Automotive Research, Development and Engineering Center Research...Mobility Model (NRMM) • Dr. M. G. Bekker of TARDEC is the “Father of Terrain-Vehicle Systems ” • NRMM was developed in 1960-70 by TARDEC and ERDC...Blocks: Scaled Experiments Particle Image Velocimetry Pressure – Sinkage Test Direct Shear Test Simulations Single Wheel Test Plate width = 50 mm

Genetically Modified Foods and Consumer Perspective.

Science.gov (United States)

Boccia, Flavio; Sarnacchiaro, Pasquale

2015-01-01

Genetically modified food is able to oppose the world's hunger and preserve the environment, even if the patents in this matter are symptomatic of several doubts. And also, transgenic consumption causes problems and skepticism among consumers in several European countries, but above all in Italy, where there is a strong opposition over recent years. So, the present study conducted a research to study the consumption of genetically modified food products by Italian young generation. This research presented the following purposes: firstly, to analyze genetically modified products' consumption among a particular category of consumers; secondly, to implement a quantitative model to understand behaviour about this particular kind of consumption and identify the factors that determine their purchase. The proposed model shows that transgenic consumption is especially linked to knowledge and impact on environment and mankind's health.

Modified Alizarin Red S-Alcian Blue Staining for Reptilian Skeleton

Directory of Open Access Journals (Sweden)

Muhammad Ja’far Luthfi

2016-04-01

Full Text Available Skeletal staining is an important method in anatomical study. The aim of the research was to develop staining and clearing method of Reptilian skeleton using Alizarin Red S-Alcian Blue. The specimen were eviscerated, fixed, stained, cleared, and keep in glycerine solution. This modified double-staining has successfully stain bone and cartilage of Reptilian.

Development of a Child Abuse Level Management (CALM) Guide for Research with Young Children.

Science.gov (United States)

Lewin, Linda C; Schim, Stephanie Myers

2016-05-01

Reporting child abuse or neglect is an ethical expectation and a legislated mandate of behavioral and health care professionals in the United States. In particular, researchers who investigate parent-child dyads are responsible for submitting procedures and informed consent documents to institutional review boards that provide for the protection of children. The challenge for researchers is to recognize failing quality of parent-child interaction, prior to any event of maltreatment and to intercede in a deteriorating dynamic. The obligation to report any suspicions of child maltreatment supersedes the responsibility to provide for confidentiality of research data. The purpose of this paper is to describe the rationale for the development of a research protocol guide, Child Abuse Level Management (CALM), and address protection of children in research. The CALM is a brief, flexible guide designed for use by researchers to help identify and respond to negative trends in the parent-child interaction during data collection. Suggested intervention scripts are provided that can be modified for specific culture-focused samples. The CALM guide can be used for training of data collectors using simulations prior to initiating any study involving higher-risk dyads. Copyright © 2015 Elsevier Inc. All rights reserved.

Chromatin-modifying proteins in cancer

DEFF Research Database (Denmark)

Fog, Cathrine K; Jensen, Klaus T; Lund, Anders Henrik

2007-01-01

-despite the fact that all cells in the organism contain the same genetic information. A large amount of data gathered over the last decades has demonstrated that deregulation of chromatin-modifying proteins is etiologically involved in the development and progression of cancer. Here we discuss how epigenetic...... alterations influence cancer development and review known cancer-associated alterations in chromatin-modifying proteins....

Physical activity and pediatric multiple sclerosis: Developing a research agenda.

Science.gov (United States)

Yeh, E Ann; Kinnett-Hopkins, Dominique; Grover, Stephanie A; Motl, Robert W

2015-11-01

Three-quarters of children with multiple sclerosis (MS) experience fatigue or depression, and progressive neurocognitive decline may be seen as early as two years after MS diagnosis. Furthermore, a higher magnetic resonance imaging disease burden is seen in pediatric-onset MS compared with adult-onset MS. To date, limited knowledge exists regarding behavioral methods for managing symptoms and disease progression in pediatric MS. To that end, this paper builds an evidence-based argument for the possible symptomatic and disease-modifying effects of exercise and physical activity in pediatric MS. This will be accomplished through: (a) a review of pediatric MS and its consequences; (b) a brief overview of physical activity and its consequences in children and adults with MS; and (c) a selective review of research on the neurological benefits of physical activity in pediatric populations. This topical review concludes with a list of 10 questions to guide future research on physical activity and pediatric MS. The objective of this paper is the provision of a research interest, focus and agenda involving pediatric MS and its lifelong management though exercise and physical activity behavior. Such an agenda is critical as the effects and maintenance of physical activity and exercise track across the lifespan, particularly when developed in the early stages of life. © The Author(s), 2015.

Artificial Neural Networks in Evaluation and Optimization of Modified Release Solid Dosage Forms

Directory of Open Access Journals (Sweden)

Zorica Djurić

2012-10-01

Full Text Available Implementation of the Quality by Design (QbD approach in pharmaceutical development has compelled researchers in the pharmaceutical industry to employ Design of Experiments (DoE as a statistical tool, in product development. Among all DoE techniques, response surface methodology (RSM is the one most frequently used. Progress of computer science has had an impact on pharmaceutical development as well. Simultaneous with the implementation of statistical methods, machine learning tools took an important place in drug formulation. Twenty years ago, the first papers describing application of artificial neural networks in optimization of modified release products appeared. Since then, a lot of work has been done towards implementation of new techniques, especially Artificial Neural Networks (ANN in modeling of production, drug release and drug stability of modified release solid dosage forms. The aim of this paper is to review artificial neural networks in evaluation and optimization of modified release solid dosage forms.

Nigerian Educational Research For Sustainable Development ...

African Journals Online (AJOL)

Education and research controls the development of any nation because no nation can rise above the products of its educational system. However, a number of problems face our educational and national development in general. The solution to such problem lies in research . educational research for sustainable ...

Development and validation of an event-specific quantitative PCR method for genetically modified maize MIR162.

Science.gov (United States)

Takabatake, Reona; Masubuchi, Tomoko; Futo, Satoshi; Minegishi, Yasutaka; Noguchi, Akio; Kondo, Kazunari; Teshima, Reiko; Kurashima, Takeyo; Mano, Junichi; Kitta, Kazumi

2014-01-01

A novel real-time PCR-based analytical method was developed for the event-specific quantification of a genetically modified (GM) maize event, MIR162. We first prepared a standard plasmid for MIR162 quantification. The conversion factor (Cf) required to calculate the genetically modified organism (GMO) amount was empirically determined for two real-time PCR instruments, the Applied Biosystems 7900HT (ABI7900) and the Applied Biosystems 7500 (ABI7500) for which the determined Cf values were 0.697 and 0.635, respectively. To validate the developed method, a blind test was carried out in an interlaboratory study. The trueness and precision were evaluated as the bias and reproducibility of relative standard deviation (RSDr). The determined biases were less than 25% and the RSDr values were less than 20% at all evaluated concentrations. These results suggested that the limit of quantitation of the method was 0.5%, and that the developed method would thus be suitable for practical analyses for the detection and quantification of MIR162.

7 CFR 906.37 - Research and development.

Science.gov (United States)

2010-01-01

... establishment of marketing research and development projects, including paid advertising, designed to assist... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 906.37 Section 906.37... LOWER RIO GRANDE VALLEY IN TEXAS Order Regulating Handling Research and Development § 906.37 Research...

Ethiopian Journal of Development Research

African Journals Online (AJOL)

Log in or Register to get access to full text downloads. ... The Ethiopian Journal of Development Research (EJDR) is a bi-annual journal devoted to ... It is devoted to the multi-disciplinary study of development problems of Ethiopia in particular ... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

The increase of compressive strength of natural polymer modified concrete with Moringa oleifera

Science.gov (United States)

Susilorini, Rr. M. I. Retno; Santosa, Budi; Rejeki, V. G. Sri; Riangsari, M. F. Devita; Hananta, Yan's. Dianaga

2017-03-01

Polymer modified concrete is one of some concrete technology innovations to meet the need of strong and durable concrete. Previous research found that Moringa oleifera can be applied as natural polymer modifiers into mortars. Natural polymer modified mortar using Moringa oleifera is proven to increase their compressive strength significantly. In this resesearch, Moringa oleifera seeds have been grinded and added into concrete mix for natural polymer modified concrete, based on the optimum composition of previous research. The research investigated the increase of compressive strength of polymer modified concrete with Moringa oleifera as natural polymer modifiers. There were 3 compositions of natural polymer modified concrete with Moringa oleifera referred to previous research optimum compositions. Several cylinder of 10 cm x 20 cm specimens were produced and tested for compressive strength at age 7, 14, and, 28 days. The research meets conclusions: (1) Natural polymer modified concrete with Moringa oleifera, with and without skin, has higher compressive strength compared to natural polymer modified mortar with Moringa oleifera and also control specimens; (2) Natural polymer modified concrete with Moringa oleifera without skin is achieved by specimens contains Moringa oleifera that is 0.2% of cement weight; and (3) The compressive strength increase of natural polymer modified concrete with Moringa oleifera without skin is about 168.11-221.29% compared to control specimens

Reliability and Validity of Modified Service Quality Instrument (SERVQUAL) in Patients' Motivation to Adhere to Insulin Therapy.

Science.gov (United States)

Jakupovic, Vedran; Solakovic, Suajb; Celebic, Nedim; Kulovic, Dzenan

2018-03-01

Diabetes is progressive condition which requires various ways of treatment. Adequate therapy prescribed in the right time helps patient to postpone development of complications. Adherence to complicated therapy is challenge for both patients and HCPs and is subject of research in many disciplines. Improvement in communication between HCP and patients is very important in patient's adherence to therapy. Aim of this research was to explore validity and reliability of modified SERVQUAL instrument in attempt to explore ways of motivating diabetic patient to accept prescribed insulin therapy. We used modified SERVQUAL questionnaire as instrument in the research. It was necessary to check validity and reliability of the new modified instrument. Results show that modified Servqual instrument has excellent reliability (α=0.908), so we could say that it measures precisely Expectations, Perceptions and Motivation at patients. Factor analysis (EFA method) with Varimax rotation extracted 4 factors which together explain 52.902% variance of the results on this subscale. Bifactorial solution could be seen on Scree-plot diagram (break at second factor). Results in this research show that modified Servqual instrument which is created in order to measure expectations and perceptions of the patients is valid and reliable. Reliability and validity are proven indeed in additional dimension which was created originally for this research - motivation to accept insulin therapy.

Reliability and Validity of Modified Service Quality Instrument (SERVQUAL) in Patients’ Motivation to Adhere to Insulin Therapy

Science.gov (United States)

Jakupovic, Vedran; Solakovic, Suajb; Celebic, Nedim; Kulovic, Dzenan

2018-01-01

Introduction: Diabetes is progressive condition which requires various ways of treatment. Adequate therapy prescribed in the right time helps patient to postpone development of complications. Adherence to complicated therapy is challenge for both patients and HCPs and is subject of research in many disciplines. Improvement in communication between HCP and patients is very important in patient’s adherence to therapy. Aim: Aim of this research was to explore validity and reliability of modified SERVQUAL instrument in attempt to explore ways of motivating diabetic patient to accept prescribed insulin therapy. Material and Methods: We used modified SERVQUAL questionnaire as instrument in the research. It was necessary to check validity and reliability of the new modified instrument. Results: Results show that modified Servqual instrument has excellent reliability (α=0.908), so we could say that it measures precisely Expectations, Perceptions and Motivation at patients. Factor analysis (EFA method) with Varimax rotation extracted 4 factors which together explain 52.902% variance of the results on this subscale. Bifactorial solution could be seen on Scree-plot diagram (break at second factor). Conclusion: Results in this research show that modified Servqual instrument which is created in order to measure expectations and perceptions of the patients is valid and reliable. Reliability and validity are proven indeed in additional dimension which was created originally for this research - motivation to accept insulin therapy. PMID:29670478

Anindya Chatterjee | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Dr Anindya Chatterjee is Regional Director, Asia, based in New Delhi, India. He has provided leadership in research, research management, policy, and program development in the area of global health and development. Dr Chatterjee formerly worked internationally with United Nations development agencies, and ...

Participatory Research and Development for Sustainable Agriculture ...

International Development Research Centre (IDRC) Digital Library (Canada)

Participatory Research and Development for Sustainable Agriculture and Natural Resource Management - A Sourcebook Volume 3 : Doing Participatory Research and Development. Couverture du livre Participatory Research and Development for Sustainable Agriculture and Natural Resource Management : A.

Chinese newspaper coverage of genetically modified organisms

Directory of Open Access Journals (Sweden)

Du Li

2012-06-01

Full Text Available Abstract Background Debates persist around the world over the development and use of genetically modified organisms (GMO. News media has been shown to both reflect and influence public perceptions of health and science related debates, as well as policy development. To better understand the news coverage of GMOs in China, we analyzed the content of articles in two Chinese newspapers that relate to the development and promotion of genetically modified technologies and GMOs. Methods Searching in the Chinese National Knowledge Infrastructure Core Newspaper Database (CNKI-CND, we collected 77 articles, including news reports, comments and notes, published between January 2002 and August 2011 in two of the major Chinese newspapers: People’s Daily and Guangming Daily. We examined articles for perspectives that were discussed and/or mentioned regarding GMOs, the risks and benefits of GMOs, and the tone of news articles. Results The newspaper articles reported on 29 different kinds of GMOs. Compared with the possible risks, the benefits of GMOs were much more frequently discussed in the articles. 48.1% of articles were largely supportive of the GM technology research and development programs and the adoption of GM cottons, while 51.9% of articles were neutral on the subject of GMOs. Risks associated with GMOs were mentioned in the newspaper articles, but none of the articles expressed negative tones in regards to GMOs. Conclusion This study demonstrates that the Chinese print media is largely supportive of GMOs. It also indicates that the print media describes the Chinese government as actively pursuing national GMO research and development programs and the promotion of GM cotton usage. So far, discussion of the risks associated with GMOs is minimal in the news reports. The media, scientists, and the government should work together to ensure that science communication is accurate and balanced.

Chinese newspaper coverage of genetically modified organisms

Science.gov (United States)

2012-01-01

Background Debates persist around the world over the development and use of genetically modified organisms (GMO). News media has been shown to both reflect and influence public perceptions of health and science related debates, as well as policy development. To better understand the news coverage of GMOs in China, we analyzed the content of articles in two Chinese newspapers that relate to the development and promotion of genetically modified technologies and GMOs. Methods Searching in the Chinese National Knowledge Infrastructure Core Newspaper Database (CNKI-CND), we collected 77 articles, including news reports, comments and notes, published between January 2002 and August 2011 in two of the major Chinese newspapers: People’s Daily and Guangming Daily. We examined articles for perspectives that were discussed and/or mentioned regarding GMOs, the risks and benefits of GMOs, and the tone of news articles. Results The newspaper articles reported on 29 different kinds of GMOs. Compared with the possible risks, the benefits of GMOs were much more frequently discussed in the articles. 48.1% of articles were largely supportive of the GM technology research and development programs and the adoption of GM cottons, while 51.9% of articles were neutral on the subject of GMOs. Risks associated with GMOs were mentioned in the newspaper articles, but none of the articles expressed negative tones in regards to GMOs. Conclusion This study demonstrates that the Chinese print media is largely supportive of GMOs. It also indicates that the print media describes the Chinese government as actively pursuing national GMO research and development programs and the promotion of GM cotton usage. So far, discussion of the risks associated with GMOs is minimal in the news reports. The media, scientists, and the government should work together to ensure that science communication is accurate and balanced. PMID:22551150

Chinese newspaper coverage of genetically modified organisms.

Science.gov (United States)

Du, Li; Rachul, Christen

2012-06-08

Debates persist around the world over the development and use of genetically modified organisms (GMO). News media has been shown to both reflect and influence public perceptions of health and science related debates, as well as policy development. To better understand the news coverage of GMOs in China, we analyzed the content of articles in two Chinese newspapers that relate to the development and promotion of genetically modified technologies and GMOs. Searching in the Chinese National Knowledge Infrastructure Core Newspaper Database (CNKI-CND), we collected 77 articles, including news reports, comments and notes, published between January 2002 and August 2011 in two of the major Chinese newspapers: People's Daily and Guangming Daily. We examined articles for perspectives that were discussed and/or mentioned regarding GMOs, the risks and benefits of GMOs, and the tone of news articles. The newspaper articles reported on 29 different kinds of GMOs. Compared with the possible risks, the benefits of GMOs were much more frequently discussed in the articles. 48.1% of articles were largely supportive of the GM technology research and development programs and the adoption of GM cottons, while 51.9% of articles were neutral on the subject of GMOs. Risks associated with GMOs were mentioned in the newspaper articles, but none of the articles expressed negative tones in regards to GMOs. This study demonstrates that the Chinese print media is largely supportive of GMOs. It also indicates that the print media describes the Chinese government as actively pursuing national GMO research and development programs and the promotion of GM cotton usage. So far, discussion of the risks associated with GMOs is minimal in the news reports. The media, scientists, and the government should work together to ensure that science communication is accurate and balanced.

Research and development and management of technology

International Nuclear Information System (INIS)

Kim, Yeong Gil

1989-04-01

This book mentions current state of affairs on research and development and prospect : activity of business, field like information and materials, energy and resource, public welfare, general industry technology. It introduces policy on promotion of research and development such as propel of special research and development business, propel strategy for 10 priority tasks, reinforcement of basic research, promotion of information industry and propel for technical development of business.

Research and development program for transuranic-contaminated waste within the U.S. Energy Research and Development Administration

International Nuclear Information System (INIS)

Wolfe, R.A.

1976-01-01

This overview examines the research and development program that has been established within the U.S. Energy Research and Development Administration (ERDA) to develop the technology to treat transuranic-contaminated waste. Also considered is the waste expected within the total nuclear fuel cycle

Research and Setting the Modified Algorithm "Predator-Prey" in the Problem of the Multi-Objective Optimization

Directory of Open Access Journals (Sweden)

A. P. Karpenko

2016-01-01

Full Text Available We consider a class of algorithms for multi-objective optimization - Pareto-approximation algorithms, which suppose a preliminary building of finite-dimensional approximation of a Pareto set, thereby also a Pareto front of the problem. The article gives an overview of population and non-population algorithms of the Pareto-approximation, identifies their strengths and weaknesses, and presents a canonical algorithm "predator-prey", showing its shortcomings. We offer a number of modifications of the canonical algorithm "predator-prey" with the aim to overcome the drawbacks of this algorithm, present the results of a broad study of the efficiency of these modifications of the algorithm. The peculiarity of the study is the use of the quality indicators of the Pareto-approximation, which previous publications have not used. In addition, we present the results of the meta-optimization of the modified algorithm, i.e. determining the optimal values of some free parameters of the algorithm. The study of efficiency of the modified algorithm "predator-prey" has shown that the proposed modifications allow us to improve the following indicators of the basic algorithm: cardinality of a set of the archive solutions, uniformity of archive solutions, and computation time. By and large, the research results have shown that the modified and meta-optimized algorithm enables achieving exactly the same approximation as the basic algorithm, but with the number of preys being one order less. Computational costs are proportionally reduced.

[Genetically modified food--unnecessary controversy?].

Science.gov (United States)

Tchórz, Michał; Radoniewicz-Chagowska, Anna; Lewandowska-Stanek, Hanna; Szponar, Elzbieta; Szponar, Jarosław

2012-01-01

Fast development of genetic engineering and biotechnology allows use of genetically modified organisms (GMO) more and more in different branches of science and economy. Every year we can see an increase of food amount produced with the use of modification of genetic material. In our supermarkets we can find brand new types of plants, products including genetically modified ingredients or meat from animals fed with food containing GMO. This article presents general information about genetically modified organisms, it also explains the range of genetic manipulation, use of newly developed products and current field area for GMO in the world. Based on scientific data the article presents benefits from development of biotechnology in reference to modified food. It also presents the voice of skeptics who are extremely concerned about the impact of those organisms on human health and natural environment. Problems that appear or can appear as a result of an increase of GMO are very important not only from a toxicologist's or a doctor's point of view but first of all from the point of view of ordinary consumers--all of us.

How a modified approach to dental coding can benefit personal and professional development with improved clinical outcomes.

Science.gov (United States)

Lam, Raymond; Kruger, Estie; Tennant, Marc

2014-12-01

One disadvantage of the remarkable achievements in dentistry is that treatment options have never been more varied or confusing. This has made the concept of Evidenced Based Dentistry more applicable to modern dental practice. Despite merit in the concept whereby clinical decisions are guided by scientific evidence, there are problems with establishing a scientific base. This is no more challenging than in modern dentistry where the gap between rapidly developing products/procedures and its evidence base are widening. Furthermore, the burden of oral disease continues to remain high at the population level. These problems have prompted new approaches to enhancing research. The aim of this paper is to outline how a modified approach to dental coding may benefit clinical and population level research. Using publically assessable data obtained from the Australian Chronic Disease Dental Scheme and item codes contained within the Australian Schedule of Dental Services and Glossary, a suggested approach to dental informatics is illustrated. A selection of item codes have been selected and expanded with the addition of suffixes. These suffixes provided circumstantial information that will assist in assessing clinical outcomes such as success rates and prognosis. The use of item codes in administering the CDDS yielded a large database of item codes. These codes are amenable to dental informatics which has been shown to enhance research at both the clinical and population level. This is a cost effective method to supplement existing research methods. Copyright © 2014 Elsevier Inc. All rights reserved.

Green chemistry measures for process research and development

Energy Technology Data Exchange (ETDEWEB)

Constable, D.J.C.; Curzons, A.D.; Freitas dos Santos, L.M. (and others)

2001-07-01

A set of metrics has been developed which enables a simple assessment to be made of batch processes in terms of waste, energy usage, and chemistry efficiency. It is intended to raise awareness of green chemistry by providing a tool to assist chemists in monitoring progress in the reduction of environmental impact as they design new routes and modify processes. (author)

Developing Effective Undergraduate Research Experience

Science.gov (United States)

Evans, Michael; Ilie, Carolina C.

2011-03-01

Undergraduate research is a valuable educational tool for students pursuing a degree in physics, but these experiences can become problematic and ineffective if not handled properly. Undergraduate research should be planned as an immersive learning experience in which the student has the opportunity to develop his/her skills in accordance with their interests. Effective undergraduate research experiences are marked by clear, measurable objectives and frequent student-professor collaboration. These objectives should reflect the long and short-term goals of the individual undergraduates, with a heightened focus on developing research skills for future use. 1. Seymour, E., Hunter, A.-B., Laursen, S. L. and DeAntoni, T. (2004), ``Establishing the benefits of research experiences for undergraduates in the sciences: First findings from a three-year study''. Science Education, 88: 493--534. 2. Behar-Horenstein, Linda S., Johnson, Melissa L. ``Enticing Students to Enter Into Undergraduate Research: The Instrumentality of an Undergraduate Course.'' Journal of College Science Teaching 39.3 (2010): 62-70.

Factors Modifying Burnout in Osteopathic Medical Students.

Science.gov (United States)

Lapinski, Jessica; Yost, Morgan; Sexton, Patricia; LaBaere, Richard J

2016-02-01

The purposes of the current study are to examine factors modifying burnout and identify which of these factors place osteopathic medical students at risk for developing burnout. The current study used a cross-sectional study design and an anonymous, web-based survey to assess burnout and depression in osteopathic medical students. The survey included Maslach Burnout Inventory, the Patient Health Questionnaire, the Stressors and their impact scale, students' sleeping and studying habits, and students' extracurricular involvement. In total, 1294 osteopathic medical students completed the survey. Burnout was present in 516 (39.9%) osteopathic medical students, and 1006 (77.0%) met criteria for depression. Females were 1.5 times more likely to be burned out in comparison to males. For the burnout subscales, males had lower emotional exhaustion, slightly higher depersonalization, and lower personal accomplishment. Lesbian/gay/bisexual/asexual students were 2.62 times more likely to be burned out compared with heterosexual students. Depression and academic, personal, and family stressors were all strongly linked to overall burnout. Finally, for modifiable factors, average hours of sleep, average hours spent studying, and club involvement appeared to be linked to burnout. The current study suggested that a variety of factors, including non-modifiable, situational, and modifiable, impact burnout in osteopathic medical students. Future research is necessary since burnout in physicians affects the quality of care provided to patients.

Using scenarios of North Slope energy and resource development to assess research and monitoring needs

Science.gov (United States)

Payne, J. F.

2016-12-01

Significant Arctic environmental and socio-economic change has been observed on the North Slope of Alaska, presenting challenges for resident communities and management agencies that need to adapt to future changes that are difficult to model or predict. Continued climate change coupled with new or modified energy development could substantially alter the landscape and ecosystem in the future. The North Slope Science Initiative (NSSI) recognized the value of using a participatory scenarios process to consider plausible future energy and resource development scenarios through the year 2040 to help identify and prioritize research and monitoring needs on the North Slope. The scenarios process engaged diverse stakeholders, including subject matter experts and local knowledge holders. Through identification and ranking of key drivers and uncertainties relevant to the focus of the study, a series of spatially explicit scenarios was developed, analyzed in terms of low, medium and high development activities. Climate change and economic factors were key drivers affecting plausible energy development scenarios. The implications from each of the scenarios were then used to identify important research and monitoring activities and their relevant spatial scales. The scenarios project identified over 40 research and monitoring needs. The top five research needs addressed data gaps and key concerns related to how the scenarios could affect: hunting and trapping on land, health and community well-being, permafrost and hydrology, marine mammal subsistence and potential marine oil spills. The use of a participatory scenarios process was essential for identifying a range of plausible energy and resource development scenarios using a framework that involved a systematic assessment of complex interacting drivers of change, consideration of key uncertainties, and transparency throughout the project.

Modifying and developing health behavior.

Science.gov (United States)

Green, L W

1984-01-01

The literatures on both behavior modification and behavioral development have engendered innovations in public health programs, addressing problems of patient adherance to preventive and therapeutic regimens, delay in seeking diagnosis of illness symptoms, risk-taking behavior, and other aspects of lifestyle associated with health. Because most of this literature derives from psychology, there has been a distinct bias in the construction of interventions, pointing them directly at individuals, usually in a counseling or small group mode of delivery. These developments served public health well enough during a decade or so when the preoccupation was with utilization of health services and medical management of chronic diseases. With the publication of the Lalonde Report in Canada in 1974, the passage of Public Law 94-317 in 1976 in the United States, and similar initiatives in other English-speaking and European countries, the recognition of the greater complexities of lifestyle development and modification in the absence of symptoms has taken hold. Policy makers and public health workers seek a more efficient and equitable set of strategies to meet the behavioral health challenges of modern society without placing the entire weight of responsibility for behavior on the individual or on therapeutic practitioners. Concurrently, on a more global scale and in the developing countries, a concern has emerged for strategies that give individuals, families, and communities a greater role in deciding their own health priorities. The convergence of these two trends--one seeking to distribute responsibility for lifestyle more equitably and the other seeking to distribute responsibility for planning health programs more equitably --calls for policies, strategies, and interventions that will place similar emphasis on health education and organizational, economic, and environmental supports for health behavior. The combination of these elements of support for behavior calls, in

Doctoral research on cadastral development

DEFF Research Database (Denmark)

Cagdas, Volkan; Stubkjær, Erik

2009-01-01

of the countries concerned. The cadastre, however, is the core of both systems as it provides for systematic and official descriptions of land parcels or real property units. The research mentioned often has a development perspective, and in this article we will motivate the introduction of the research domain...... of cadastral development. This research is multi-disciplinary and draws on elements of theories and methodologies from the natural, the social, the behavioral, and the formal sciences. During the last decade or so, doctoral dissertations have come to constitute a substantial part of this research effort...... with a call for a shared terminology and a shared set of concepts which may contribute to further theory building within the cadastral domain. Udgivelsesdato: OCT...

Mitochondrial haplogroups modify the risk of developing hypertrophic cardiomyopathy in a Danish population

DEFF Research Database (Denmark)

Hagen, Christian M; Aidt, Frederik H; Hedley, Paula L

2013-01-01

Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in genes coding for proteins involved in sarcomere function. The disease is associated with mitochondrial dysfunction. Evolutionarily developed variation in mitochondrial DNA (mtDNA), defining mtDNA haplogroups and haplog......Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in genes coding for proteins involved in sarcomere function. The disease is associated with mitochondrial dysfunction. Evolutionarily developed variation in mitochondrial DNA (mtDNA), defining mtDNA haplogroups...... factors in the development of HCM. Thus, constitutive differences in mitochondrial function may influence the occurrence and clinical presentation of HCM. This could explain some of the phenotypic variability in HCM. The fact that haplogroup H and J are also modifying factors in ischemic cardiomyopathy...

Ethiopian Journal of Development Research: Advanced Search

African Journals Online (AJOL)

PROMOTING ACCESS TO AFRICAN RESEARCH ... Ethiopian Journal of Development Research: Advanced Search ... containing either term; e.g., education OR research; Use parentheses to create more complex queries; ... Ethiopian Journal of Business and Economics (The), Ethiopian Journal of Development Research ...

7 CFR 984.46 - Research and development.

Science.gov (United States)

2010-01-01

... research and development projects, and marketing promotion, including paid advertising, designed to assist... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 984.46 Section 984.46... Regulating Handling Administrative Body § 984.46 Research and development. The Board, with the approval of...

7 CFR 993.37 - Research and development.

Science.gov (United States)

2010-01-01

... CALIFORNIA Order Regulating Handling Prune Marketing Committee § 993.37 Research and development. The... research and development projects designed to assist, improve, or promote the marketing, distribution, and... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 993.37 Section 993.37...

Journal of Agricultural Research and Development

African Journals Online (AJOL)

The Journal of Agricultural Research and Development aims at publishing research reports, short communications, Critical Reviews in Agricultural Economics and Farm Management, Agronomy, Forestry, Animal Science, Food Technology, Soil Science, Home Economics, Agricultural Extension, Rural development, ...

Risk Assessment of Genetically Modified Microorganisms

DEFF Research Database (Denmark)

Jacobsen, B. L.; Wilcks, Andrea

2001-01-01

the industry, national administration and research institutions were gathered to discuss which elements should be considered in a risk assessment of genetically modified microorganisms used as food or food ingredients. The existing EU and national regulations were presented, together with the experiences......The rapid development of recombinant DNA techniques for food organisms urges for an ongoing discussion on the risk assessment of both new as traditional use of microorganisms in food production. This report, supported by the Nordic Council of Ministers, is the result of a workshop where people from...... with risk assessment of these organisms in each Nordic country....

Scientific and Regulatory Considerations in Solid Oral Modified Release Drug Product Development.

Science.gov (United States)

Li, Min; Sander, Sanna; Duan, John; Rosencrance, Susan; Miksinski, Sarah Pope; Yu, Lawrence; Seo, Paul; Rege, Bhagwant

2016-11-01

This review presents scientific and regulatory considerations for the development of solid oral modified release (MR) drug products. It includes a rationale for patient-focused development based on Quality-by-Design (QbD) principles. Product and process understanding of MR products includes identification and risk-based evaluation of critical material attributes (CMAs), critical process parameters (CPPs), and their impact on critical quality attributes (CQAs) that affect the clinical performance. The use of various biopharmaceutics tools that link the CQAs to a predictable and reproducible clinical performance for patient benefit is emphasized. Product and process understanding lead to a more comprehensive control strategy that can maintain product quality through the shelf life and the lifecycle of the drug product. The overall goal is to develop MR products that consistently meet the clinical objectives while mitigating the risks to patients by reducing the probability and increasing the detectability of CQA failures.

Assessing and monitoring impacts of genetically modified plants on agro-ecosystems: the approach of AMIGA project

Directory of Open Access Journals (Sweden)

S. Arpaia

2014-06-01

Full Text Available The environmental impacts of genetically modified crops is still a controversial issue in Europe. The overall risk assessment framework has recently been reinforced by the European Food Safety Authority(EFSA and its implementation requires harmonized and efficient methodologies. The EU-funded research project AMIGA − Assessing and monitoring Impacts of Genetically modified plants on Agro-ecosystems − aims to address this issue, by providing a framework that establishes protection goals and baselines for European agro-ecosystems, improves knowledge on the potential long term environmental effects of genetically modified (GM plants, tests the efficacy of the EFSA Guidance Document for the Environmental Risk Assessment, explores new strategies for post market monitoring, and provides a systematic analysis of economic aspects of Genetically Modified crops cultivation in the EU. Research focuses on ecological studies in different EU regions, the sustainability of GM crops is estimated by analysing the functional components of the agro-ecosystems and specific experimental protocols are being developed for this scope.

Translational Research and Youth Development

Science.gov (United States)

Hamilton, Stephen F.

2015-01-01

Borrowing the term "translational research" (TR) from medicine, along with some of the ideas and practices that define it, holds promise as a way of linking research more closely to the practice of youth development. However, doing so entails substantial adaptation. TR is more than a new name for applied research. It comprehends the…

A Promising Combo Gene Delivery System Developed from (3-Aminopropyl)triethoxysilane-Modified Iron Oxide Nanoparticles and Cationic Polymers

Science.gov (United States)

Zhang, Zubin; Song, Lina; Dong, Jinlai; Guo, Dawei; Du, Xiaolin; Cao, Biyin; Zhang, Yu; Gu, Ning; Mao, Xinliang

2013-05-01

(3-Aminopropyl)triethoxysilane-modified iron oxide nanoparticles (APTES-IONPs) have been evaluated for various biomedical applications, including medical imaging and drug delivery. Cationic polymers (CPs) such as Lipofectamine and TurboFect are widely used for research in gene delivery, but their toxicity and low in vivo efficiency limited their further application. In the present study, we synthesized water-soluble APTES-IONPs and developed a combo gene delivery system based on APTES-IONPs and CPs. This system significantly increased gene-binding capacity, protected genes from degradation, and improved gene transfection efficiency for DNA and siRNA in both adherent and suspension cells. Because of its great biocompatibility, high gene-carrying ability, and very low cytotoxicity, this combo gene delivery system will be expected for a wide application, and it might provide a new method for gene therapy.

A Promising Combo Gene Delivery System Developed from (3-Aminopropyl)triethoxysilane-Modified Iron Oxide Nanoparticles and Cationic Polymers

International Nuclear Information System (INIS)

Zhang Zubin; Song Lina; Dong Jinlai; Guo Dawei; Du Xiaolin; Cao Biyin; Zhang Yu; Gu Ning; Mao Xinliang

2013-01-01

(3-Aminopropyl)triethoxysilane-modified iron oxide nanoparticles (APTES-IONPs) have been evaluated for various biomedical applications, including medical imaging and drug delivery. Cationic polymers (CPs) such as Lipofectamine and TurboFect are widely used for research in gene delivery, but their toxicity and low in vivo efficiency limited their further application. In the present study, we synthesized water-soluble APTES-IONPs and developed a combo gene delivery system based on APTES-IONPs and CPs. This system significantly increased gene-binding capacity, protected genes from degradation, and improved gene transfection efficiency for DNA and siRNA in both adherent and suspension cells. Because of its great biocompatibility, high gene-carrying ability, and very low cytotoxicity, this combo gene delivery system will be expected for a wide application, and it might provide a new method for gene therapy.

Developing the procedure of modifying the denture soft liner by silver nanoparticles.

Science.gov (United States)

Chladek, Grzegorz; Barszczewska-Rybarek, Izabela; Lukaszczyk, Jan

2012-01-01

Colonization of denture soft lining materials by fungi and denture plaque leads to infections of mucosa. Microorganisms such as Candida albicans colonize not only the surface of the soft liners, but they also penetrate inside those materials. Therefore the use of common disinfectants, e.g., surface active cleaners, is not a perfect solution for keeping a proper hygiene of soft linings. Modifying soft lining by silver nanoparticles (AgNP) seems to be a right way to overcome those problems. The procedure of modifying two-component silicone material by silver nanoparticles (AgNP) is presented in the article. The solubility tests for both material components have been carried out in the first stage of examinations. On the basis of test results, a solvent has been selected, being a dispersion medium for AgNPs and both soft liner components. The effective method for evaporating a solvent from the composition has been developed. Material components with various AgNP concentrations (10, 20, 40, 80, 120 and 200 ppm) have been obtained. Cured samples of the composites have been examined by SEM to confirm the effectiveness of the procedure.

Fresh and Hardened State of Polymer Modified Concrete and Mortars – A Review

Directory of Open Access Journals (Sweden)

Tukimat Nurul Nadrah Aqilah

2017-01-01

Full Text Available Polymer modified concrete or mortar is an alternative to the advancement of long serving civil engineering material - mortar and concrete. The excellence and promising benefits of modified composites have led to numerous progressive studies of its application. This paper presented a critical review from previous research on the polymer modified concrete and mortar. Both fresh and hardened state behaviours were reviewed as they are important for the development of excellent engineering material. Most of the applications of polymer modified concrete and mortar can be seen in diverse types of polymer such as latex, epoxy and emulsion. The utilization of each type of polymers resulted in different characteristics of composite concrete or mortar. Such applications have contributed to the improvement in terms of workability and mechanical strength, especially at higher grade of composite strength of concrete material.

Research Libraries and the internet

DEFF Research Database (Denmark)

Finnemann, Niels Ole

2014-01-01

The paper argues that digital media have a disruptive potential, but path dependency is often a modifying component in the historical development. This is demonstrated in different stages of the development of the interrelationship between digitization, digital media and research libraries. Today...... the historical dynamic has reached a point where all institutions concerned with knowledge handling will have to redefine themselves. Research libraries are gradually incorporated into a number of new “research infrastructures” which are being built around different kinds of data materials, and each research...... library may specialize according to some sort of coordinated criteria....

Development of a research evaluation protocol for NSD research portfolios

International Nuclear Information System (INIS)

Gould, J.

1999-01-01

This report is concerned with developing and describing a research evaluation protocol for use by the Nuclear Safety Directorate (NSD), in evaluating their various programmes of research; or aspects of those programmes. The Health and Safety Executive (HSE) has been involved with research evaluation for some considerable time and NSD, as part of HSE, wishes to develop a protocol which, while it meets their needs, is also fully compatible with other HSE approaches. It is intended that the methodology developed by this project will be used for evaluation of the Probabilistic Safety Assessment Portfolio (as a separate project). The usefulness of the methodology will be reviewed in the light of this experience

Exploring areas of consensus and conflict around values underpinning public involvement in health and social care research: a modified Delphi study

Science.gov (United States)

Snape, D; Kirkham, J; Preston, J; Popay, J; Britten, N; Collins, M; Froggatt, K; Gibson, A; Lobban, F; Wyatt, K; Jacoby, A

2014-01-01

Objective There is growing interest in the potential benefits of public involvement (PI) in health and social care research. However, there has been little examination of values underpinning PI or how these values might differ for different groups with an interest in PI in the research process. We aimed to explore areas of consensus and conflict around normative, substantive and process-related values underpinning PI. Design Mixed method, three-phase, modified Delphi study, conducted as part of a larger multiphase project. Setting The UK health and social care research community. Participants Stakeholders in PI in research, defined as: clinical and non-clinical academics, members of the public, research managers, commissioners and funders; identified via research networks, online searches and a literature review. Results We identified high levels of consensus for many normative, substantive and process-related issues. However, there were also areas of conflict in relation to issues of bias and representativeness, and around whether the purpose of PI in health and social care research is to bring about service change or generate new knowledge. There were large differences by group in the percentages endorsing the ethical justification for PI and the argument that PI equalises power imbalances. With regard to practical implementation of PI, research support infrastructures were reported as lacking. Participants reported shortcomings in the uptake and practice of PI. Embedding PI practice and evaluation in research study designs was seen as fundamental to strengthening the evidence base. Conclusions Our findings highlight the extent to which PI is already embedded in research. However, they also highlight a need for ‘best practice’ standards to assist research teams to understand, implement and evaluate PI. These findings have been used in developing a Public Involvement Impact Assessment Framework (PiiAF), which offers guidance to researchers and members of the

Macroparticle acceleration from a modified mather-type plasma gun

International Nuclear Information System (INIS)

Hou, W.S.; Yeh, T.R.; Wen, M.; Yeh, C.K.; Shang, D.J.

1987-01-01

The use of electromagnetic force to accelerate projectiles of a few grams in a plasma-driven railgun device was described recently. Since then, subsequent research along this development has been exploited at many laboratories. As part of the plasma focus research project, an effort of modified Mather-type plasma gun has also been constructed at the Institute of Nuclear Energy Research (INER) for impact studies. The idea takes the advantage of accelerating plasmas with JxB force toward the muzzle of the gun and then strikes the projecticle to transfer their kinetic energy. Preliminary results indicate that the projecticle velocity of 1.1 km/sec can be achieved routinely with a 1.2-gram stainless steel projectile

Development and study the performance of PBA cladding modified fiber optic intrinsic biosensor for urea detection

Energy Technology Data Exchange (ETDEWEB)

Botewad, S. N.; Pahurkar, V. G.; Muley, G. G., E-mail: gajananggm@yahoo.co.in [Department of Physics, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India-444602 (India)

2016-05-06

The fabrication and study of a cladding modified fiber optic intrinsic urea biosensor based on evanescent wave absorbance has been presented. The sensor was prepared using cladding modification technique by removing a small portion of cladding of an optical fiber and modifying with an active cladding of porous polyaniline-boric acid (PBA) matrix to immobilize enzyme-urease through cross-linking via glutaraldehyde. The nature of as-synthesized and deposited PBA film on fiber optic sensing element was studied by ultraviolet-visible (UV-vis) spectroscopy and X-ray diffraction (XRD) analysis. The performance of the developed sensor was studied for different urea concentrations in solutions prepared in phosphate buffer.

Developing Disease-Modifying Treatments in Alzheimer's Disease - A Perspective from Roche and Genentech.

Science.gov (United States)

Doody, R

2017-01-01

Alzheimer's disease (AD) is a chronic neurodegenerative disease for which no preventative or disease-modifying treatments currently exist. Pathological hallmarks include amyloid plaques and neurofibrillary tangles composed of hyper-phosphorylated tau protein. Evidence suggests that both pathologies are self-propagating once established. However, the lag time between neuropathological changes in the brain and the onset of even subtle clinical symptomatology means that patients are often diagnosed late when pathology, and neurodegeneration secondary to these changes, may have been established for several years. Complex pathological pathways associated with susceptibility to AD and changes that occur downstream of the neuropathologic process further contribute to the challenging endeavour of developing novel disease-modifying therapy. Recognising this complexity, effective management of AD must include reliable screening and early diagnosis in combination with effective therapeutic management of the pathological processes. Roche and Genentech are committed to addressing these unmet needs through developing a comprehensive portfolio of diagnostics and novel therapies. Beginning with the most scientifically supported targets, this approach includes two targeted amyloid-β monoclonal antibody therapies, crenezumab and gantenerumab, and an anti-tau monoclonal antibody, RO7105705, as well as a robust biomarker platform to aid in the early identification of people at risk or in the early stages of AD. Identification and implementation of diagnostic tools will support the enrolment of patients into clinical trials; furthermore, these tools should also support evaluation of the clinical efficacy and safety profile of the novel therapeutic agents tested in these trials. This review discusses the therapeutic agents currently under clinical development.

Research and Development programs for HTGRs in JAERI

Energy Technology Data Exchange (ETDEWEB)

Nishiguchi, Isoharu; Saito, Sinzo [Department of HTTR Project, Japan Atomic Energy Research Institute (Japan)

1990-07-01

Since 1969, JAERI has conducted research and development (R and D) programs for High-Temperature Gas-Cooled Reactors (HTGR). And the High Temperature engineering Test Reactor (HTTR), which will be the first High Temperature Gas Cooled Reactor (HTGR) in Japan, is under licensing process now. In this paper, some of the results of R and D are outlined in the following fields which are closely connected with the HTTR design, that is: i) fuel; ii) nuclear design; iii) thermal-hydraulic design; iv) graphite structure and v) high temperature metal structure. In the field of fuel, extensive investigations have been performed to develop the fabrication technology of coated particle fuel (cpf). In parallel, data of coated fuel particle failure and fission product release in in- and ex-reactor experiments as well as mechanical properties data were obtained and irradiation tests have been done using the Oarai Gas Loop No.1 (OGL-1) to verify the integrity of mass-produced fuel. Concerning the nuclear design, critical experiments were conducted using the Very High-Temperature Reactor Critical Assembly (VHTRC). Also carried out were hydrodynamical and thermal experiments using the Helium Engineering Demonstration Loop (HENDEL). On the graphite structures which compose the reactor internals, design criteria have been developed based on ASME BandPV Code Section III Div.2, subsection CE and design data have been accumulated on a domestic graphite material. High temperature metal structure is also one of major subjects of R and D for HTGRs. Hastelloy XR, which is a modified version of Hastelloy X, was developed and various tests have been conducted which include creep tests, creep-fatigue tests, etc. to establish design criteria and allowables. Component tests of the Intermediate Heat Exchanger (IHX) have been also performed. (author)

Research and Development programs for HTGRs in JAERI

International Nuclear Information System (INIS)

Nishiguchi, Isoharu; Saito, Sinzo

1990-01-01

Since 1969, JAERI has conducted research and development (R and D) programs for High-Temperature Gas-Cooled Reactors (HTGR). And the High Temperature engineering Test Reactor (HTTR), which will be the first High Temperature Gas Cooled Reactor (HTGR) in Japan, is under licensing process now. In this paper, some of the results of R and D are outlined in the following fields which are closely connected with the HTTR design, that is: i) fuel; ii) nuclear design; iii) thermal-hydraulic design; iv) graphite structure and v) high temperature metal structure. In the field of fuel, extensive investigations have been performed to develop the fabrication technology of coated particle fuel (cpf). In parallel, data of coated fuel particle failure and fission product release in in- and ex-reactor experiments as well as mechanical properties data were obtained and irradiation tests have been done using the Oarai Gas Loop No.1 (OGL-1) to verify the integrity of mass-produced fuel. Concerning the nuclear design, critical experiments were conducted using the Very High-Temperature Reactor Critical Assembly (VHTRC). Also carried out were hydrodynamical and thermal experiments using the Helium Engineering Demonstration Loop (HENDEL). On the graphite structures which compose the reactor internals, design criteria have been developed based on ASME BandPV Code Section III Div.2, subsection CE and design data have been accumulated on a domestic graphite material. High temperature metal structure is also one of major subjects of R and D for HTGRs. Hastelloy XR, which is a modified version of Hastelloy X, was developed and various tests have been conducted which include creep tests, creep-fatigue tests, etc. to establish design criteria and allowables. Component tests of the Intermediate Heat Exchanger (IHX) have been also performed. (author)

Photonics Research and Development

Energy Technology Data Exchange (ETDEWEB)

Dickson, Elizabeth [UNLV Research Foundation, Las Vegas, NV (United States)

2010-01-15

During the period August 2005 through October 2009, the UNLV Research Foundation (UNLVRF), a non-profit affiliate of the University of Nevada, Las Vegas (UNLV), in collaboration with UNLV's Colleges of Science and Engineering; Boston University (BU); Oak Ridge National Laboratory (ORNL); and Sunlight Direct, LLC, has managed and conducted a diverse and comprehensive research and development program focused on light-emitting diode (LED) technologies that provide significantly improved characteristics for lighting and display applications. This final technical report provides detailed information on the nature of the tasks, the results of the research, and the deliverables. It is estimated that about five percent of the energy used in the nation is for lighting homes, buildings and streets, accounting for some 25 percent of the average home's electric bill. However, the figure is significantly higher for the commercial sector. About 60 percent of the electricity for businesses is for lighting. Thus replacement of current lighting with solid-state lighting technology has the potential to significantly reduce this nation's energy consumption by some estimates, possibly as high as 20%. The primary objective of this multi-year R&D project has been to develop and advance lighting technologies to improve national energy conversion efficiencies; reduce heat load; and significantly lower the cost of conventional lighting technologies. The UNLVRF and its partners have specifically focused these talents on (1) improving LED technologies; (2) optimizing hybrid solar lighting, a technology which potentially offers the benefits of blending natural with artificial lighting systems, thus improving energy efficiency; and (3) building a comprehensive academic infrastructure within UNLV which concentrates on photonics R&D. Task researchers have reported impressive progress in (1) the development of quantum dot laser emitting diodes (QDLEDs) which will ultimately improve

78 FR 28630 - Pfizer Therapeutic Research, Pfizer Worldwide Research & Development Division, Formerly Known as...

Science.gov (United States)

2013-05-15

... Research, Pfizer Worldwide Research & Development Division, Formerly Known as Warner Lambert Company... Groton, Connecticut location of Pfizer Therapeutic Research, Pfizer Worldwide Research & Development... Worldwide Research & Development Division, formerly known as Warner Lambert Company, Comparative Medicine...

Hypothetical link between infertility and genetically modified food.

Science.gov (United States)

Gao, Mingxia; Li, Bin; Yuan, Wenzhen; Zhao, Lihui; Zhang, Xuehong

2014-01-01

It is speculated that genetically modified food (GMF)/genetically modified organism (GMO) is responsible for infertility development. The risk linked with a wide use of GMFs/GMOs offers the basic elements for social criticism. However, to date, it has not been justified whether the bad effects are directly resulted from products of genetic modifications or trans-genesis process. Extensive experience with the risk assessment of whole foods has been applied recently on the safety and nutritional testing of GMFs/GMOs. Investigations have tested the safety of GMFs including sub-acute, chronic, reproductive, multi-generation and carcinogenicity studies. We extrapolated the potential risks associated with GMFs/GMOs on reproduction, and analyzed the multi-aspect linked between infertility and GMFs/GMOs. It could be conjectured that GMFs/GMOs could be potential hazard on reproduction, linking to the development of infertility through influencing the endocrine metabolism, endometriosis. However, little evidence shows the impaction on embryo or reproductive related tumor due to the limited literatures, and needs further research. The article presents some related patents on GMFs/GMOs, and some methods for tracking GMOs.

Status of prompt gamma neutron activation analysis (PGAA) at TRR-1/M1 (Thai Research Reactor-1/Modified 1)

Energy Technology Data Exchange (ETDEWEB)

Asvavijnijkulchai, Chanchai; Dharmavanij, Wanchai; Siangsanan, Pariwat; Ratanathongchai, Wichian; Chongkum, Somporn [Physics Division, Office of Atomic Energy for Peace, Vibhavadi Rangsit Road, Chatuchak, Bangkok (Thailand)

1999-08-01

The first prompt gamma activation analysis (PGAA) was designed, constructed and installed at a 6 inch diameter neutron beam port of the Thai Research Reactor-1/Modified 1 (TRR-1/M1) since 1989. Beam characteristic were made by Gd foil irradiation, X-ray film exposing and densitometry scanning consequently. The thermal neutron flux at sample position was measured by Au foil activation, and was about 1 x 10{sup 7} n.cm{sup 2}.sec{sup -1} at 700 kW operating power. The experiments have been conducted successfully. In 1998, the PGAA facility has been developed for the reactor operating power at 1.2 MW. The new PGAA system, e.g., beam shutter, gamma collimator and biological shields have been designed to reduce the leakage of neutrons and gamma radiation to the acceptance levels in accordance with the International Commission on Radiation Protection Publication 60 (ICRP 60). The construction and installation will be completed in April 1999. (author)

Status of prompt gamma neutron activation analysis (PGAA) at TRR-1/M1 (Thai Research Reactor-1/Modified 1)

International Nuclear Information System (INIS)

Asvavijnijkulchai, Chanchai; Dharmavanij, Wanchai; Siangsanan, Pariwat; Ratanathongchai, Wichian; Chongkum, Somporn

1999-01-01

The first prompt gamma activation analysis (PGAA) was designed, constructed and installed at a 6 inch diameter neutron beam port of the Thai Research Reactor-1/Modified 1 (TRR-1/M1) since 1989. Beam characteristic were made by Gd foil irradiation, X-ray film exposing and densitometry scanning consequently. The thermal neutron flux at sample position was measured by Au foil activation, and was about 1 x 10 7 n.cm 2 .sec -1 at 700 kW operating power. The experiments have been conducted successfully. In 1998, the PGAA facility has been developed for the reactor operating power at 1.2 MW. The new PGAA system, e.g., beam shutter, gamma collimator and biological shields have been designed to reduce the leakage of neutrons and gamma radiation to the acceptance levels in accordance with the International Commission on Radiation Protection Publication 60 (ICRP 60). The construction and installation will be completed in April 1999. (author)

78 FR 28292 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Science.gov (United States)

2013-05-14

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit Review Board; Notice of Meetings; Amendment The... Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development...

7 CFR 916.45 - Marketing research and development.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Marketing research and development. 916.45 Section 916... GROWN IN CALIFORNIA Order Regulating Handling Research § 916.45 Marketing research and development. The... research, marketing research and development projects designed to assist, improve, or promote the marketing...

PENERAPAN PENDEKATAN MODIFIED FREE INQUIRY SEBAGAI UPAYA MENINGKATKAN KREATIVITAS MAHASISWA CALON GURU DALAM MENGEMBANGKAN JENIS EKSPERIMEN DAN PEMAHAMAN TERHADAP MATERI FISIKA

Directory of Open Access Journals (Sweden)

S Khanafiyah

2010-04-01

Full Text Available This research aims to improve the creativity of students in developing experiments and the understanding of physics; especially wave; using application of modified free inquiry. This research is conducted in Physics Department, of Unnes. Questionnaire is used to measure creativity, observation sheet to measure the psychomotoric ability, while test sheets to measure the understanding of waves subject matter. Results were analyzed using a Likert scale. To test the effectiveness of modified free inquiry approach in enhancing students‟ creativity and students' understanding of the wave subject matter, normalized gain formula is used. The results shows that by implementing modified free inquiry approaching in the learning process and allowing the students to apply their creativity, will remedy students‟ psychomotoric ability, increasing the number of the experiments type, enhancing students' creativity and cognitive abilities. It is suggested that lecturer gradually and continously provides opportunity for learners to develop their creativity. Kata kunci : modified free inquiry, creativity

LIDAR Research & Development Lab

Data.gov (United States)

Federal Laboratory Consortium — The LIDAR Research and Development labs are used to investigate and improve LIDAR components such as laser sources, optical signal detectors and optical filters. The...

Allosteric regulation of epigenetic modifying enzymes.

Science.gov (United States)

Zucconi, Beth E; Cole, Philip A

2017-08-01

Epigenetic enzymes including histone modifying enzymes are key regulators of gene expression in normal and disease processes. Many drug development strategies to target histone modifying enzymes have focused on ligands that bind to enzyme active sites, but allosteric pockets offer potentially attractive opportunities for therapeutic development. Recent biochemical studies have revealed roles for small molecule and peptide ligands binding outside of the active sites in modulating the catalytic activities of histone modifying enzymes. Here we highlight several examples of allosteric regulation of epigenetic enzymes and discuss the biological significance of these findings. Copyright © 2017 Elsevier Ltd. All rights reserved.

Research and Development from the bottom up

DEFF Research Database (Denmark)

Brem, Alexander; Wolfram, P.

2014-01-01

and ecological context or the growing interest of developed market firms in approaches from emerging markets. Hence, the presented framework supports further research in new paradigms for research and development (R&D) in developed market firms (DMFs), particularly in relation to emerging markets. This framework...... enables scholars to compare concepts from developed and emerging markets, to address studies specifically by using consistent terms, and to advance research into the concepts according their characterization....

Defense Nanotechnology Research and Development Program

National Research Council Canada - National Science Library

2007-01-01

...), Army Research Office (ARO) and the Air Force Office of Scientific Research (AFOSR)initiated numerous research and development programs focusing on advancing science and technology below one micron in size...

Space biology research development

Science.gov (United States)

Bonting, Sjoerd L.

1993-01-01

The purpose of the Search for Extraterrestrial Intelligence (SETI) Institute is to conduct and promote research related activities regarding the search for extraterrestrial life, particularly intelligent life. Such research encompasses the broad discipline of 'Life in the Universe', including all scientific and technological aspects of astronomy and the planetary sciences, chemical evolution, the origin of life, biological evolution, and cultural evolution. The primary purpose was to provide funding for the Principal Investigator to collaborate with the personnel of the SETI Institute and the NASA-Ames Research center in order to plan and develop space biology research on and in connection with Space Station Freedom; to promote cooperation with the international partners in the space station; to conduct a study on the use of biosensors in space biology research and life support system operation; and to promote space biology research through the initiation of an annual publication 'Advances in Space Biology and Medicine'.

Development of Global Change Research in Developing Countries

Science.gov (United States)

Sierra, Carlos A.; Yepes, Adriana P.

2010-10-01

Ecosystems and Global Change in the Context of the Neotropics; Medellín, Colombia, 19-20 May 2010; Research in most areas of global environmental change is overwhelmingly produced outside developing countries, which are usually consumers rather than producers of the knowledge associated with their natural resources. While there have been important recent advances in understanding the causes of global-¬scale changes and their consequences to the functioning of tropical ecosystems, there is still an important gap in the understanding of these changes at regional and national levels (where important political decisions are usually made). A symposium was held with the aim of surveying the current state of research activities in a small, developing country such as Colombia. It was jointly organized by the Research Center on Ecosystems and Global Change, Carbono and Bosques; the National University of Colombia at Medellín and the Colombian Ministry of the Environment, Housing, and Regional Development. This 2-¬day symposium gathered Colombian and international scientists involved in different areas of global environmental change, tropical ecosystems, and human societies.

Acquiring research-grade ERPs on a shoestring budget: A comparison of a modified Emotiv and commercial SynAmps EEG system.

Science.gov (United States)

Barham, Michael P; Clark, Gillian M; Hayden, Melissa J; Enticott, Peter G; Conduit, Russell; Lum, Jarrad A G

2017-09-01

This study compared the performance of a low-cost wireless EEG system to a research-grade EEG system on an auditory oddball task designed to elicit N200 and P300 ERP components. Participants were 15 healthy adults (6 female) aged between 19 and 40 (M = 28.56; SD = 6.38). An auditory oddball task was presented comprising 1,200 presentations of a standard tone interspersed by 300 trials comprising a deviant tone. EEG was simultaneously recorded from a modified Emotiv EPOC and a NeuroScan SynAmps RT EEG system. The modifications made to the Emotiv system included attaching research grade electrodes to the Bluetooth transmitter. Additional modifications enabled the Emotiv system to connect to a portable impedance meter. The cost of these modifications and portable impedance meter approached the purchase value of the Emotiv system. Preliminary analyses revealed significantly more trials were rejected from data acquired by the modified Emotiv compared to the SynAmps system. However, the ERP waveforms captured by the Emotiv system were found to be highly similar to the corresponding waveform from the SynAmps system. The latency and peak amplitude of N200 and P300 components were also found to be similar between systems. Overall, the results indicate that, in the context of an oddball task, the ERP acquired by a low-cost wireless EEG system can be of comparable quality to research-grade EEG acquisition equipment. © 2017 Society for Psychophysiological Research.

Developing a Physiotherapy-Specific Preliminary Clinical Decision-Making Tool for Oxygen Titration: A Modified Delphi Study

Science.gov (United States)

Duong, Michelle; Bertin, Kendra; Henry, Renee; Singh, Deepti; Timmins, Nolla; Brooks, Dina; Mathur, Sunita

2014-01-01

ABSTRACT Purpose: To develop and evaluate a preliminary clinical decision-making tool (CDMT) to assist physiotherapists in titrating oxygen for acutely ill adults in Ontario. Methods: A panel of 14 experienced cardiorespiratory physiotherapists was recruited. Factors relating to oxygen titration were identified using a modified Delphi technique. Four rounds of questionnaires were conducted, during which the goals were to (1) generate factors, (2) reduce factors and debate contentious factors, (3) finalize factors and develop the preliminary CDMT, and (4) evaluate the usability of the tool in a clinical context. Results: The panel reached consensus on a total of 89 factors, which were compiled to create the preliminary CDMT. The global tool reached consensus for sensibility, receiving a mean score of 6/7 on a 7-point Likert-type scale (1=unacceptable; 7=excellent). Five of the nine individual components of evaluation of the tool achieved scores ≥6.0; the remaining four had mean scores between 5.4 and 5.9. Conclusion: This study produced a preliminary CDMT for oxygen titration, which the panel agreed was highly comprehensible and globally sensible. Further research is necessary to evaluate the sensibility and applicability of the tool in a clinical setting. PMID:25125782

[Research progress in chemical communication among insect-resistant genetically modified plants, insect pests and natural enemies].

Science.gov (United States)

Liu, Qing-Song; Li, Yun-He; Chen, Xiu-Ping; Peng, Yu-Fa

2014-08-01

Semiochemicals released by plants or insects play an important role in the communication among plants, phytophagous insects and their natural enemies. They thus form a chemical information network which regulates intra- and inter-specific behaviors and sustains the composition and structure of plant and insect communities. The application of insect-resistant genetically modified (IRGM) crops may affect the chemical communication within and among the tritrophic levels, and thus cause disturbances to the biotic community structure and the stability of the farmland ecosystem. This has raised concerns about the environmental safety of IRGM crops and triggered research worldwide. In the current article we provided a brief summary of the chemical communication among plants, herbivores and natural enemies; analyzed the potential of IRGM crops to affect the chemical communication between plants and arthropods and the related mechanisms; and discussed the current research progress and the future prospects in this field. We hope that this will promote the research in this field by Chinese scientists and increase our understanding of the potential effects of growing of IRGM crops on the arthropod community structure.

Participatory Research and Development for Sustainable Agriculture ...

International Development Research Centre (IDRC) Digital Library (Canada)

It is crucial, for example, that local stakeholders provide input to the process. Participatory research and ... Participatory Research and Development for Sustainable Agriculture and Natural Resource Management - A Sourcebook Volume 2: Enabling Participatory Research and Development. Book cover Participatory ...

Developing Research Competence in Undergraduate Students through Hands on Learning

Directory of Open Access Journals (Sweden)

Zoe E. Davidson

2015-01-01

Full Text Available Evidence-based practice is the foundation of nutrition and dietetics. To effectively apply evidence-based practice, health professionals must understand the basis of research. Previous work has identified the lack of involvement of dietitians in research. As part of a curriculum redevelopment in undergraduate nutrition and dietetics courses, research skill teaching was enhanced. This study evaluated the effect of a new, year two level nutrition research methods unit on the perceived research skills of students. The unit consisted of two key components: a student-led class research project and a small group systematic literature review. Prior to commencement and on completion of the course, students completed a modified version of the Research Skills Questionnaire. Results demonstrated that self-perceived competence increased by a small degree in a set of specific research skills as well as in broader skills such as information gathering and handling, information evaluation, ability to work independently, and critical thinking. The new research unit was also evaluated highly on a student satisfaction survey. Despite these positive findings, students indicated that their general feelings towards research or a career in research were unchanged. In summary, this unit enhanced students’ perceived research skills. Further exploration of students’ attitude towards research is warranted.

7 CFR 924.45 - Research and development.

Science.gov (United States)

2010-01-01

... establishment of production research, and marketing research and development projects designed to assist... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 924.45 Section 924.45 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing...

7 CFR 929.45 - Research and development.

Science.gov (United States)

2010-01-01

... establishment of production research, marketing research, and market development projects, including paid... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 929.45 Section 929.45 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing...

Fiscal 1999 research achievement report on the development of SNPs related technologies; 1999 nendo SNPs kanren gijutsu kaihatsu seika hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

Efforts are made to develop specimen processing technologies for modifying and enabling various kinds of specimens to automatically undergo SNP (single nucleotide polymorphism) analysis for medicine development and clinical diagnostic activities and to develop technologies and apparatuses to enable rapid, inexpensive, and simple search and analysis of SNPs using DNA (deoxyribonucleic acid) chips and mass spectrometry. Activities are conducted in the four fields involving (1) the development of a practical clinical system for rapid detection and analysis of SNPs, (2) research and development of an SNP scoring system using bar-coded oligonucleotides and magnetic beads, (3) research and development of a high-speed SNP analysis system using a mass spectrometer, and (4) the development of a high throughput SNP analysis line. Efforts exerted in field (1) involve a protein fixation method using plasma polymerization and its application to DNA arrays, development of an SNP detection method using human genomes, construction of a rapid DNA detection device using an electric field, development of an SNP analysis system using the solid phase HPA (hybridization protection assay) method, and SNP analysis using solid phase ligation. (NEDO)

Improving the performance of the Egyptian second testing nuclear research reactor using interval type-2 fuzzy logic controller tuned by modified biogeography-based optimization

Energy Technology Data Exchange (ETDEWEB)

Sayed, M.M., E-mail: M.M.Sayed@ieee.org; Saad, M.S.; Emara, H.M.; Abou El-Zahab, E.E.

2013-09-15

Highlights: • A modified version of the BBO was proposed. • A novel method for interval type-2 FLC design tuned by MBBO was proposed. • The performance of the ETRR-2 was improved by using IT2FLC tuned by MBBO. -- Abstract: Power stabilization is a critical issue in nuclear reactors. The conventional proportional derivative (PD) controller is currently used in the Egyptian second testing research reactor (ETRR-2). In this paper, we propose a modified biogeography-based optimization (MBBO) algorithm to design the interval type-2 fuzzy logic controller (IT2FLC) to improve the performance of the Egyptian second testing research reactor (ETRR-2). Biogeography-based optimization (BBO) is a novel evolutionary algorithm that is based on the mathematical models of biogeography. Biogeography is the study of the geographical distribution of biological organisms. In the BBO model, problem solutions are represented as islands, and the sharing of features between solutions is represented as immigration and emigration between the islands. A modified version of the BBO is applied to design the IT2FLC to get the optimal parameters of the membership functions of the controller. We test the optimal IT2FLC obtained by modified biogeography-based optimization (MBBO) using the integral square error (ISE) and is compared with the currently used PD controller.

[Study on recent status of development of genetically modified animals developed not for food purposes].

Science.gov (United States)

Nakajima, Osamu; Akiyama, Hiroshi; Teshima, Reiko

2012-01-01

Genetically modified (GM) animals can be classified into two groups, those developed for food purposes and those developed not for food purposes. We investigated the recent status of development of GM animals developed not for food purposes. Among the GM animals developed not for food purposes, GM fish, chickens, and pigs were selected because many articles have been published on these organisms. Relevant articles published between 2008 and 2011 were surveyed using PubMed and transgenic fish, chicken, or pig as keywords. Then, studies on organisms that could potentially contaminate the food chain with products from these GM animals were selected and analyzed. Fifteen articles on GM fish were found. These articles were classified into four categories: bioreactor (n = 4), resistance to microorganisms (n = 6), resistance to environmental stresses (n = 1), and detection of chemicals (n = 4). Zebrafish were used in 8 of the articles. Six, three, and three articles were reported from Taiwan, Canada and China. Seven articles on GM chickens were found. These articles were classified into two categories: bioreactor (n = 5), and resistance to pathogens (n = 2). Two articles were reported from Japan and Korea, each. As for GM pigs, 43 articles were found. These articles were classified into three categories: xenotransplantation (n = 36), bioreactor (n = 6), and environmental cleanup (n = 1). Nineteen, seven, six, and five articles were reported from USA, Germany, Korea and Taiwan, respectively. Understanding the recent development of GM animals produced not for food purpose is important for assuring the safety of food.

Modified HWBI Model(s) Linking Service Flows to Well-Being Endpoints: Accounting for Environmental Quality

Science.gov (United States)

This report describes an approach for modifying ORD’s Human Well-Being Index (HWBI) to increase its utility by introducing a composite index developed independently of the HWBI effort. Using ORD’s Environmental Quality Index (EQI), this research examines the potential...

An improved algorithm for searching all minimal cuts in modified networks

International Nuclear Information System (INIS)

Yeh, W.-C.

2008-01-01

A modified network is an updated network after inserting a branch string (a special path) between two nodes in the original network. Modifications are common for network expansion or reinforcement evaluation and planning. The problem of searching all minimal cuts (MCs) in a modified network is discussed and solved in this study. The existing best-known methods for solving this problem either needed extensive comparison and verification or failed to solve some special but important cases. Therefore, a more efficient, intuitive and generalized method for searching all MCs without an extensive research procedure is proposed. In this study, we first develop an intuitive algorithm based upon the reformation of all MCs in the original network to search for all MCs in a modified network. Next, the correctness of the proposed algorithm will be analyzed and proven. The computational complexity of the proposed algorithm is analyzed and compared with the existing best-known methods. Finally, two examples illustrate how all MCs are generated in a modified network using the information of all of the MCs in the corresponding original network

Publications | Page 31 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 301 - 310 of 6388 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

Publications | Page 36 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 351 - 360 of 6341 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

Publications | Page 87 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 861 - 870 of 6381 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

Publications | Page 4 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 31 - 40 of 6375 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

Publications | Page 82 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 811 - 820 of 6372 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

Publications | Page 85 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 841 - 850 of 6381 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

Publications | Page 17 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 161 - 170 of 6379 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

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International Development Research Centre (IDRC) Digital Library (Canada)

Results 211 - 220 of 2177 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

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International Development Research Centre (IDRC) Digital Library (Canada)

Results 281 - 290 of 6341 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

View all initiatives | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

The International Research Chairs Initiative pairs top research talent from universities in Canada with their counterparts in developing countries to address key development challenges. We fund researchers driving global change. Careers · Contact Us · Subscribe · Unsubscribe · Site map. Follow us; Facebook · Twitter ...

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International Development Research Centre (IDRC) Digital Library (Canada)

Results 551 - 560 of 6381 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

7 CFR 959.48 - Research and development.

Science.gov (United States)

2010-01-01

... approval of the Secretary, may establish or provide for the establishment of production research, marketing research, and development projects designed to assist, improve, or promote the marketing, distribution... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 959.48 Section 959.48...

Publications | Page 26 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 251 - 260 of 6378 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

Publications | Page 22 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 211 - 220 of 6379 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the ...

Progress in the development of very high density research and test reactor fuels

Energy Technology Data Exchange (ETDEWEB)

Wachs, D.M. [Idaho National Laboratory, P.O. Box 2528, Idaho Falls, Idaho 83415 (United States)

2009-06-15

New nuclear fuels are being developed to enable many of the most important research and test reactors worldwide to convert from high enriched uranium (HEU) fuels to low enriched uranium (LEU) fuels without significant loss in performance. The last decade of work has focused on the development of uranium-molybdenum alloy (U-Mo) based fuels and is an international effort that includes the active participation of more than ten national programs. The US RERTR program, under the NNSA's Global Threat Reduction Initiative (GTRI), is in the process of developing both dispersion and monolithic U-Mo fuel designs. While the U-Mo fuel alloy has behaved extremely well under irradiation, initial testing (circa 2003) revealed that the U-Mo fuels dispersed in aluminum had an unexpected tendency toward unstable swelling (pillowing) under high-power conditions. Technical investigations were initiated worldwide at this time by the partner programs to understand this behavior as well as to develop and test remedies. The behavior was corrected by modifying the chemistry of the U-Mo/Al interfaces in both fuel designs. In the dispersion fuel design, this was accomplished by the addition of small amounts of silicon to the aluminum matrix material. Two methods are under development for the monolithic fuel design, which include the application of a thin layer of silicon or a thin zirconium based diffusion barrier at the fuel/clad interface. This paper gives an overview of the current status of U-Mo fuel development, including basic research results, manufacturing aspects, results of the latest irradiations and post irradiation examinations, the approach to fuel performance qualification, and the scale-up and commercialization of fabrication technology. (authors)

Operational forecasting based on a modified Weather Research and Forecasting model

Energy Technology Data Exchange (ETDEWEB)

Lundquist, J; Glascoe, L; Obrecht, J

2010-03-18

Accurate short-term forecasts of wind resources are required for efficient wind farm operation and ultimately for the integration of large amounts of wind-generated power into electrical grids. Siemens Energy Inc. and Lawrence Livermore National Laboratory, with the University of Colorado at Boulder, are collaborating on the design of an operational forecasting system for large wind farms. The basis of the system is the numerical weather prediction tool, the Weather Research and Forecasting (WRF) model; large-eddy simulations and data assimilation approaches are used to refine and tailor the forecasting system. Representation of the atmospheric boundary layer is modified, based on high-resolution large-eddy simulations of the atmospheric boundary. These large-eddy simulations incorporate wake effects from upwind turbines on downwind turbines as well as represent complex atmospheric variability due to complex terrain and surface features as well as atmospheric stability. Real-time hub-height wind speed and other meteorological data streams from existing wind farms are incorporated into the modeling system to enable uncertainty quantification through probabilistic forecasts. A companion investigation has identified optimal boundary-layer physics options for low-level forecasts in complex terrain, toward employing decadal WRF simulations to anticipate large-scale changes in wind resource availability due to global climate change.

77 FR 26069 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Science.gov (United States)

2012-05-02

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit Review Board, Notice of Meeting Amendment The... Development and Clinical Science Research and Development Services Scientific Merit Review Board have changed...

Laboratory Directed Research ampersand Development Program

International Nuclear Information System (INIS)

Ogeka, G.J.; Romano, A.J.

1993-12-01

At Brookhaven National Laboratory the Laboratory Directed Research and Development (LDRD) Program is a discretionary research and development tool critical in maintaining the scientific excellence and vitality of the laboratory. It is also a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor in achieving and maintaining staff excellence, and a means to address national needs, within the overall mission of the Department of Energy and Brookhaven National Laboratory. This report summarizes research which was funded by this program during fiscal year 1993. The research fell in a number of broad technical and scientific categories: new directions for energy technologies; global change; radiation therapies and imaging; genetic studies; new directions for the development and utilization of BNL facilities; miscellaneous projects. Two million dollars in funding supported 28 projects which were spread throughout all BNL scientific departments

Global research and development budget

Energy Technology Data Exchange (ETDEWEB)

Norman, C

1980-03-01

The future political and economic relationships between industrial countries and between the industrial and developing countries will be influenced by the investments now being made for research and development (R and D). There is little public understanding of this $150 billion global investment, 25 percent of which is spent on military programs, 15 percent on basic research, and nearly 10 percent on space exploration, while the most-pressing world problems are receiving relatively little attention. A breakdown of geographic distribution of research and a comparison of government expenditures for different areas of R and D reveals a situation that could be corrected. National and corporate priorities need to be revised and political and institutional barriers must give way to new international and cooperative arrangements. 3 tables, 27 references. (DCK)

Novel bioactive materials developed by simulated body fluid evaluation: Surface-modified Ti metal and its alloys.

Science.gov (United States)

Kokubo, Tadashi; Yamaguchi, Seiji

2016-10-15

Until the discovery of the bone-bonding activity of Bioglass by Hench et al. in the early 1970s, it had not been demonstrated that a synthetic material could bond to living bone without eliciting a foreign body reaction. Since then, various kinds of materials based on calcium phosphate, such as sintered hydroxyapatite and β-tricalcium phosphate have also been shown to bond to living bone. Until the discovery of the bone-bonding activity of Ti metal formed with a sodium titanate surface layer by the present authors in 1996, it had not been shown that a metallic material could bond to living bone. Since then, various kinds of surface-modified Ti metal and its alloys have been found to bond to living bone. Until the discovery of the osteoinduction of porous hydroxyapatite by Yamasaki in 1990, it was unknown whether a synthetic material could induce bone formation even in muscle tissue. Since then, various kinds of porous calcium phosphate ceramics have been shown to induce osteoinduction. Until the discovery of osteoinduction induced by a porous Ti metal formed with a titanium oxide surface layer by Fujibayashi et al. in 2004, it had been unclear whether porous metals would be able to induce osteoinduction. These novel bioactive materials have been developed by systematic research into the apatite formation that occurs on surface-modified Ti metal and its related materials in an acellular simulated body fluid (SBF) having ion concentrations almost equal to those of human blood plasma. Some of the novel bioactive materials based on Ti metal are already in clinical use or clinical trials, such as artificial hip joints and spinal fusion devices. In the present paper, we review how these novel bioactive materials based on Ti metal have been developed based on an evaluation of apatite formation in SBF. Without the SBF evaluation, these novel bioactive materials would most likely never have been developed. On the basis of systematic study of apatite formation on a material

Fostering Collaborations towards Integrative Research Development

Directory of Open Access Journals (Sweden)

Leonie Valentine

2013-05-01

Full Text Available The complex problems associated with global change processes calls for close collaboration between science disciplines to create new, integrated knowledge. In the wake of global change processes, forests and other natural environments have been rapidly changing, highlighting the need for collaboration and integrative research development. Few tools are available to explore the potential for collaborations in research ventures that are just starting up. This study presents a useful approach for exploring and fostering collaborations between academics working in research teams and organizations comprising multiple science disciplines (i.e., multi-disciplinary. The research aim was to reveal potential barriers, common ground, and research strengths between academics working in a new centre focused on forest and climate change research. This aim was based on the premise that raising awareness and working with this acquired knowledge fosters collaborations and integrative research development. An email survey was deployed amongst the academics to obtain: (i their understanding of common themes (e.g., climate change, scale of investigation, woodland/forest health/decline; (ii descriptions of the spatial and temporal scales of their research; and (iii their approach and perceived contributions to climate change research. These data were analysed using a semi-quantitative content analysis approach. We found that the main potential barriers were likely to be related to differences in understanding of the common research themes, whilst similarities and disciplinary strengths provided critical elements to foster collaborations. These findings were presented and discussed amongst the centre academics to raise awareness and create a dialogue around these issues. This process resulted in the development of four additional research projects involving multiple disciplines. The approach used in this study provides a useful methodology of broader benefit to

Agricultural extension, research, and development for increased ...

African Journals Online (AJOL)

The challenges of food security and agricultural development in South Africa cannot simply be solved by limiting extension and research development to the public sector. However, if shortcomings arise in the public sector while addressing extension, research and development, the potential involvement of the private sector ...

Critical Issues in Research Design in Action Research in an SME Development Context

Science.gov (United States)

McGrath, Helen; O'Toole, Thomas

2012-01-01

Purpose: The main aim of this paper is to develop guidelines on the critical issues to consider in research design in an action research (AR) environment for SME network capability development. Design/methodology/approach: The issues in research design for AR studies are developed from the authors' experience in running learning sets but, in…

Development and interlaboratory validation of quantitative polymerase chain reaction method for screening analysis of genetically modified soybeans.

Science.gov (United States)

Takabatake, Reona; Onishi, Mari; Koiwa, Tomohiro; Futo, Satoshi; Minegishi, Yasutaka; Akiyama, Hiroshi; Teshima, Reiko; Kurashima, Takeyo; Mano, Junichi; Furui, Satoshi; Kitta, Kazumi

2013-01-01

A novel real-time polymerase chain reaction (PCR)-based quantitative screening method was developed for three genetically modified soybeans: RRS, A2704-12, and MON89788. The 35S promoter (P35S) of cauliflower mosaic virus is introduced into RRS and A2704-12 but not MON89788. We then designed a screening method comprised of the combination of the quantification of P35S and the event-specific quantification of MON89788. The conversion factor (Cf) required to convert the amount of a genetically modified organism (GMO) from a copy number ratio to a weight ratio was determined experimentally. The trueness and precision were evaluated as the bias and reproducibility of relative standard deviation (RSDR), respectively. The determined RSDR values for the method were less than 25% for both targets. We consider that the developed method would be suitable for the simple detection and approximate quantification of GMO.

7 CFR 932.45 - Production research and marketing research and development projects.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Production research and marketing research and....45 Production research and marketing research and development projects. (a) The following activities... Secretary, establish or provide for the establishment of production research, and marketing research and...

Collaborative Engineering for Research and Development

Science.gov (United States)

Davis, Jose M.; Keys, L. Ken; Chen, Injazz J.

2004-01-01

Research and development (R&D) organizations are being required to be relevant, to be more application-oriented, and to be partners in the strategic management of the business while meeting the same challenges as the rest of the organization, namely: (1) reduced time to market; (2) reduced cost; (3) improved quality; (4) increased reliability; and (5) increased focus on customer needs. Recent advances in computer technology and the Internet have created a new paradigm of collaborative engineering or collaborative product development (CPD), from which new types of relationships among researchers and their partners have emerged. Research into the applicability and benefits of CPD in a low/no production, R&D, and/or government environment is limited. In addition, the supply chain management (SCM) aspects of these relationships have not been studied. This paper presents research conducted at the NASA Glenn Research Center (GRC) investigating the applicability of CPD and SCM in an R&D organization. The study concentrates on the management and implementation of space research activities at GRC. Results indicate that although the organization is engaged in collaborative relationships that incorporate aspects of SCM, a number of areas, such as development of trust and information sharing merit special attention.

The development of a modified composition of ceramic mass for the production of bricks

OpenAIRE

Torosyan, Vera Fedorovna; Torosyan, Elena Samvelovna; Yakutova, V. A.; Antyufeev, V. K.

2016-01-01

The need to improve the technical level of production of construction materials, their product range, to improve product quality and reduce its cost requires the expansion of the raw material base, the use of resource and energy saving technology and design solutions. To implement all these it is necessary to conduct a more detailed study of the properties of ceramic materials and to investigate the behavior-modifying components of their formulations. This paper presents the development of th...

The Interrater Reliability of the Modified Gait Abnormality Rating Scale for Use with People with Intellectual Disability

Science.gov (United States)

Hale, Leigh; McIlraith, Lucy; Miller, Clare; Stanley-Clarke, Terri; George, Rebecca

2010-01-01

Background: Researching falls in persons with ID is limited by difficulties in applying standardised balance outcome measures. The modified Gait Abnormality Rating Scale (GARS-M), developed to identify falls risk in older adults, requires only that the participant walks and thus may be a feasible falls research tool to use with people with ID. In…

Nuclear safeguards research and development

Science.gov (United States)

Henry, C. N.

1981-11-01

The status of a nuclear safeguard research and development program is presented. Topics include nondestructive assay technology development and applications, international safeguards, training courses, technology transfer, analytical chemistry methods for fissionable materials safeguards, the Department of Energy Computer Security Technical Center, and operational security.

Automated DNA extraction from genetically modified maize using aminosilane-modified bacterial magnetic particles.

Science.gov (United States)

Ota, Hiroyuki; Lim, Tae-Kyu; Tanaka, Tsuyoshi; Yoshino, Tomoko; Harada, Manabu; Matsunaga, Tadashi

2006-09-18

A novel, automated system, PNE-1080, equipped with eight automated pestle units and a spectrophotometer was developed for genomic DNA extraction from maize using aminosilane-modified bacterial magnetic particles (BMPs). The use of aminosilane-modified BMPs allowed highly accurate DNA recovery. The (A(260)-A(320)):(A(280)-A(320)) ratio of the extracted DNA was 1.9+/-0.1. The DNA quality was sufficiently pure for PCR analysis. The PNE-1080 offered rapid assay completion (30 min) with high accuracy. Furthermore, the results of real-time PCR confirmed that our proposed method permitted the accurate determination of genetically modified DNA composition and correlated well with results obtained by conventional cetyltrimethylammonium bromide (CTAB)-based methods.

Biocompatible Silver Nanoparticle-Modified Natural Diatomite with Anti-Infective Property

Directory of Open Access Journals (Sweden)

Haolin Sun

2018-01-01

Full Text Available Nanosilver as an alternative antibacterial agent of antibiotics has been researched for possible applications in various orthopedic implants. However, it is imperative to achieve controllable release of Ag+ to reduce its cytotoxic effect on normal tissue. Here, a nanosilver release system that has potential to be used in anti-infective bone cement was reported. Nanosilver modified diatomite was developed through the reaction of Tollens’ reagent to improve the antibacterial effect and natural diatomite was used as the carrier of Ag+ ions for controlled release. Cytotoxicity and the antibacterial activities of the nanosilver release system were characterized. After 3 days, the NIH3T3 cells cultured in the extract of nanosilver modified diatomite with an initial concentration of 0.5 mg/ml showed better cell viability than cells cultured in α-MEM. The density of MC3T3-E1 cells cultured in the extract of nanosilver modified diatomite at the same concentration did not differ significantly from the density of cells cultured in α-MEM. The nanosilver modified diatomite exhibited antibacterial effect against E. coli and S. aureus when the concentration was higher than 0.5 mg/ml. With appropriate selection of Ag+ concentration, the nanosilver modified diatomite is promising for improving the antibacterial effect while not affecting the biocompatibility of reinforced calcium phosphate bone cement.

Low temperature electrical transport in modified carbon nanotube fibres

International Nuclear Information System (INIS)

Lekawa-Raus, Agnieszka; Walczak, Kamil; Kozlowski, Gregory; Hopkins, Simon C.; Wozniak, Mariusz; Glowacki, Bartek A.; Koziol, Krzysztof

2015-01-01

Carbon nanotube fibres are a new class of materials highly promising for many electrical/electronic applications. The range of applications could be extended through the modification of their electrical transport properties by inclusions of foreign materials. However, the changes in electrical transport are often difficult to assess. Here, we propose that the analysis of resistance–temperature dependencies of modified fibres supported by a recently developed theoretical model may aid research in this area and accelerate real life applications of the fibres

Development of an Electronic Pediatric All-Cause Harm Measurement Tool Using a Modified Delphi Method.

Science.gov (United States)

Stockwell, David Christopher; Bisarya, Hema; Classen, David C; Kirkendall, Eric S; Lachman, Peter I; Matlow, Anne G; Tham, Eric; Hyman, Dan; Lehman, Samuel M; Searles, Elizabeth; Muething, Stephen E; Sharek, Paul J

2016-12-01

To have impact on reducing harm in pediatric inpatients, an efficient and reliable process for harm detection is needed. This work describes the first step toward the development of a pediatric all-cause harm measurement tool by recognized experts in the field. An international group of leaders in pediatric patient safety and informatics were charged with developing a comprehensive pediatric inpatient all-cause harm measurement tool using a modified Delphi technique. The process was conducted in 5 distinct steps: (1) literature review of triggers (elements from a medical record that assist in identifying patient harm) for inclusion; (2) translation of triggers to likely associated harm, improving the ability for expert prioritization; (3) 2 applications of a modified Delphi selection approach with consensus criteria using severity and frequency of harm as well as detectability of the associated trigger as criteria to rate each trigger and associated harm; (4) developing specific trigger logic and relevant values when applicable; and (5) final vetting of the entire trigger list for pilot testing. Literature and expert panel review identified 108 triggers and associated harms suitable for consideration (steps 1 and 2). This list was pared to 64 triggers and their associated harms after the first of the 2 independent expert reviews. The second independent expert review led to further refinement of the trigger package, resulting in 46 items for inclusion (step 3). Adding in specific trigger logic expanded the list. Final review and voting resulted in a list of 51 triggers (steps 4 and 5). Application of a modified Delphi method on an expert-constructed list of 108 triggers, focusing on severity and frequency of harms as well as detectability of triggers in an electronic medical record, resulted in a final list of 51 pediatric triggers. Pilot testing this list of pediatric triggers to identify all-cause harm for pediatric inpatients is the next step to establish the

Classroom Research and Professional Development

Directory of Open Access Journals (Sweden)

Omaira Vergara Luján

2009-04-01

Full Text Available This article intends to share the experience of a group of teachers in the Classroom Research Seminar of the Teacher Development Program in English carried out at Universidad del Valle, Cali, from January to June, 2007. The seminar was part of a high-level in-service program for teachers of English of a network of private educational institutions. We would like to share the highlights and difficulties of the experience. We will start with the general framework of the program and the concept of professional development that underlies it. Next we will focus on the classroom research seminar, its objectives, methodology and results. Finally we share the voices of some of the participants, who talk about the influence this seminar had on their professional development and daily work.

Research and Development Information System (RDIS)

Data.gov (United States)

Department of Veterans Affairs — The Research and Development Information System (RDIS) is the Veterans Affairs Central Office budgetary and project data repository for managing the VA Research and...

Gas cooled fast reactor research and development program

International Nuclear Information System (INIS)

Markoczy, G.; Hudina, M.; Richmond, R.; Wydler, P.; Stratton, R.W.; Burgsmueller, P.

1980-03-01

The research and development work in the field of core thermal-hydraulics, steam generator research and development, experimental and analytical physics and carbide fuel development carried out 1979 for the Gas Cooled Fast Breeder Reactor at the Swiss Federal Institute for Reactor Research is described. (Auth.)

Modifier genes: Moving from pathogenesis to therapy.

Science.gov (United States)

McCabe, Edward R B

2017-09-01

This commentary will focus on how we can use our knowledge about the complexity of human disease and its pathogenesis to identify novel approaches to therapy. We know that even for single gene Mendelian disorders, patients with identical mutations often have different presentations and outcomes. This lack of genotype-phenotype correlation led us and others to examine the roles of modifier genes in the context of biological networks. These investigations have utilized vertebrate and invertebrate model organisms. Since one of the goals of research on modifier genes and networks is to identify novel therapeutic targets, the challenges to patient access and compliance because of the high costs of medications for rare genetic diseases must be recognized. A recent article explored protective modifiers, including plastin 3 (PLS3) and coronin 1C (CORO1C), in spinal muscular atrophy (SMA). SMA is an autosomal recessive deficit of survival motor neuron protein (SMN) caused by mutations in SMN1. However, the severity of SMA is determined primarily by the number of SMN2 copies, and this results in significant phenotypic variability. PLS3 was upregulated in siblings who were asymptomatic compared with those who had SMA2 or SMA3, but identical homozygous SMN1 deletions and equal numbers of SMN2 copies. CORO1C was identified by interrogation of the PLS3 interactome. Overexpression of these proteins rescued endocytosis in SMA models. In addition, antisense RNA for upregulation of SMN2 protein expression is being developed as another way of modifying the SMA phenotype. These investigations suggest the practical application of protective modifiers to rescue SMA phenotypes. Other examples of the potential therapeutic value of novel protective modifiers will be discussed, including in Duchenne muscular dystrophy and glycerol kinase deficiency. This work shows that while we live in an exciting era of genomic sequencing, a functional understanding of biology, the impact of its

Maturity Models Development in IS Research

DEFF Research Database (Denmark)

Lasrado, Lester Allan; Vatrapu, Ravi; Andersen, Kim Normann

2015-01-01

Maturity models are widespread in IS research and in particular, IT practitioner communities. However, theoretically sound, methodologically rigorous and empirically validated maturity models are quite rare. This literature review paper focuses on the challenges faced during the development...... literature reveals that researchers have primarily focused on developing new maturity models pertaining to domain-specific problems and/or new enterprise technologies. We find rampant re-use of the design structure of widely adopted models such as Nolan’s Stage of Growth Model, Crosby’s Grid, and Capability...... Maturity Model (CMM). Only recently have there been some research efforts to standardize maturity model development. We also identify three dominant views of maturity models and provide guidelines for various approaches of constructing maturity models with a standard vocabulary. We finally propose using...

48 CFR 216.104-70 - Research and development.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Research and development... Contract Types § 216.104-70 Research and development. Follow the procedures at PGI 216.104-70 for selecting the appropriate research and development contract type. [71 FR 39007, July 11, 2006] ...

Research and development project in fiscal 1988 for fundamental technologies for next generation industries. Achievement report on research and development on high crystallinity polymeric materials; 1988 nendo kokesshosei kobunshi zairyo no kenkyu kaihatsu seika hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1989-03-01

With an objective to realize structural materials characterized by light weight, high corrosion resistance and easy-to-process performance, research and development has been performed on high crystallinity polymeric materials. This paper summarizes the achievement in fiscal 1988. With regard to monophyletic materials, using thermotropic liquid crystal polyallylate as the object, researches were performed on optimization, polymerization, and elongation fluid orientation processing of the polymer chemical structures. In the polyphyletic materials, discussions were given on aromatic heterocyclic polymers as to the synthesizing process for PIBO expected of higher elasticity rate than with PIBT. Discussions were given on the phase transfer transient film making process for molecular composites for an attempt of enhancing performance of tapes and laminates. With regard to cross-linking materials, forming and improvements were discussed on heat hardening molecular composites of ionic/inorganic hybrid cross-linking polymer, modified ion cross-linking polymer, poly-ion complex, and diacetylene polymer. In addition, researches were performed on the high-density three-dimensional cross-linking process and inter-molecular reinforcement of mono-axially and highly oriented substances to obtain high elasticity forms. (NEDO)

The Cardiovascular Health in Ambulatory Care Research Team performance indicators for the primary prevention of cardiovascular disease: a modified Delphi panel study.

Science.gov (United States)

Tu, Jack V; Maclagan, Laura C; Ko, Dennis T; Atzema, Clare L; Booth, Gillian L; Johnston, Sharon; Tu, Karen; Lee, Douglas S; Bierman, Arlene; Hall, Ruth; Bhatia, R Sacha; Gershon, Andrea S; Tobe, Sheldon W; Sanmartin, Claudia; Liu, Peter; Chu, Anna

2017-04-25

High-quality ambulatory care can reduce cardiovascular disease risk, but important gaps exist in the provision of cardiovascular preventive care. We sought to develop a set of key performance indicators that can be used to measure and improve cardiovascular care in the primary care setting. As part of the Cardiovascular Health in Ambulatory Care Research Team initiative, we established a 14-member multidisciplinary expert panel to develop a set of indicators for measuring primary prevention performance in ambulatory cardiovascular care. We used a 2-stage modified Delphi panel process to rate potential indicators, which were identified from the literature and national cardiovascular organizations. The top-rated indicators were pilot tested to determine their measurement feasibility with the use of data routinely collected in the Canadian health care system. A set of 28 indicators of primary prevention performance were identified, which were grouped into 5 domains: risk factor prevalence, screening, management, intermediate outcomes and long-term outcomes. The indicators reflect the major cardiovascular risk factors including smoking, obesity, hypertension, diabetes, dyslipidemia and atrial fibrillation. All indicators were determined to be amenable to measurement with the use of population-based administrative (physician claims, hospital admission, laboratory, medication), survey or electronic medical record databases. The Cardiovascular Health in Ambulatory Care Research Team indicators of primary prevention performance provide a framework for the measurement of cardiovascular primary prevention efforts in Canada. The indicators may be used by clinicians, researchers and policy-makers interested in measuring and improving the prevention of cardiovascular disease in ambulatory care settings. Copyright 2017, Joule Inc. or its licensors.

Legal protection of public health through control over genetically modified food.

Science.gov (United States)

Gutorova, Nataliya; Batyhina, Olena; Trotska, Maryna

2018-01-01

Introduction: Science is constantly being developed which leads to both positive and negative changes in public health and the environment. One of the results of scientific progress is introduction of food based on genetically modified organisms whose effects on human health, to date, remain scantily studied and are ambiguous. The aim: to determine how human health can be influenced by food production based on genetically modified organisms. Materials and methods: international acts, data of international organizations and conclusions of scientists have been examined and used in the study. The article also summarizes information from scientific journals and monographs from a medical and legal point of view with scientific methods. This article is based on dialectical, comparative, analytic, synthetic and comprehensive research methods. Conclusions: Genetically modified organisms are specific human-made organisms being a result of using modern biotechnology techniques. They have both positive and negative effects on human health and the environment. The main disadvantage is not sufficient study of them in various spheres of public life.

Publications | Page 11 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 101 - 110 of 6389 ... IDRC works with developing-country researchers and ... impact of our investment and advance development research. ... on a daily basis to her family in Huallhua, a tiny farming community in Peru's Andes Mountains.

Modifiable risk factors of hypertension and socio demographic ...

African Journals Online (AJOL)

Background: Factors associated with the development of hypertension can be categorized into modifiable and non‑modifiable risk factors. The modifiable risk factors include obesity, physical inactivity, high salt diet, smoking alcohol consumption and others. Aim: This study was aimed to determine the prevalence of ...

Environmental Biotechnology Research and Development Program 1989-1992

OpenAIRE

Brinkman J; Rulkens WH; Visscher K

1989-01-01

This report is an English translation of the Dutch Research and Development Program on environmental biotechnology 1989-1992. In this program an overview is given of the recent developments in environmental biotechnology. Based on this overview, the possibilities of biotechnology for management of the environment are evaluated. In this program two kinds of research are distinguished. Applied research directly focusses on specific environmental problems. Fundamental research aims at developing...

7 CFR 905.54 - Marketing, research and development.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Marketing, research and development. 905.54 Section... Marketing, research and development. The committee may, with the approval of the Secretary, establish, or provide for the establishment of, projects including production research, marketing research and...

Development of anti-inflammatory drugs - the research and development process.

Science.gov (United States)

Knowles, Richard Graham

2014-01-01

The research and development process for novel drugs to treat inflammatory diseases is described, and several current issues and debates relevant to this are raised: the decline in productivity, attrition, challenges and trends in developing anti-inflammatory drugs, the poor clinical predictivity of experimental models of inflammatory diseases, heterogeneity within inflammatory diseases, 'improving on the Beatles' in treating inflammation, and the relationships between big pharma and biotechs. The pharmaceutical research and development community is responding to these challenges in multiple ways which it is hoped will lead to the discovery and development of a new generation of anti-inflammatory medicines. © 2013 Nordic Pharmacological Society. Published by John Wiley & Sons Ltd.

[The modified method registration of kinesthetic evoked potentials and its application for research of proprioceptive sensitivity disorders at spondylogenic cervical myelopathy].

Science.gov (United States)

Gordeev, S A; Voronin, S G

2016-01-01

To analyze the efficacy of modified (passive radiocarpal articulation flexion/extension) and «standard» (passive radiocarpal articulation flexion) methods of kinesthetic evoked potentials for proprioceptive sensitivity assessment in healthy subjects and patients with spondylotic cervical myelopathy. The study included 14 healthy subjects (4 women and 10 men, mean age 54.1±10.5 years) and 8 patients (2 women and 6 men, mean age 55.8±10.9 years) with spondylotic cervical myelopathy. Muscle-joint sensation was examined during the clinical study. A modified method of kinesthetic evoked potentials was developed. This method differed from the "standard" one by the organization of a cycle including several passive movements,where each new movement differed from the preceding one by the direction. The modified method of kinesthetic evoked potentials ensures more reliable kinesthetic sensitivity assessment due to movement variability. Asignificant increaseof the latent periods of the early components of the response was found in patients compared to healthy subjects. The modified method of kinesthetic evoked potentials can be used for objective diagnosis of proprioceptive sensitivity disorders in patients with spondylotic cervical myelopathy.

48 CFR 31.205-48 - Research and development costs.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Research and development... Organizations 31.205-48 Research and development costs. Research and development, as used in this subsection... grant for research and development effort, the excess is unallowable under any other Government contract...

Journal of Agricultural Research and Development

African Journals Online (AJOL)

The Journal of Agricultural Research and Development aims at publishing research reports, short communications, Critical Reviews in Agricultural Economics and Farm ... Response of Sesamum radiatum Schum vegetable and seed yield to ...

Genetically modified foods and allergy.

Science.gov (United States)

Lee, T H; Ho, H K; Leung, T F

2017-06-01

2015 marked the 25th anniversary of the commercial use and availability of genetically modified crops. The area of planted biotech crops cultivated globally occupies a cumulative two billion hectares, equivalent to twice the land size of China or the United States. Foods derived from genetically modified plants are widely consumed in many countries and genetically modified soybean protein is extensively used in processed foods throughout the industrialised countries. Genetically modified food technology offers a possible solution to meet current and future challenges in food and medicine. Yet there is a strong undercurrent of anxiety that genetically modified foods are unsafe for human consumption, sometimes fuelled by criticisms based on little or no firm evidence. This has resulted in some countries turning away food destined for famine relief because of the perceived health risks of genetically modified foods. The major concerns include their possible allergenicity and toxicity despite the vigorous testing of genetically modified foods prior to marketing approval. It is imperative that scientists engage the public in a constructive evidence-based dialogue to address these concerns. At the same time, improved validated ways to test the safety of new foods should be developed. A post-launch strategy should be established routinely to allay concerns. Mandatory labelling of genetically modified ingredients should be adopted for the sake of transparency. Such ingredient listing and information facilitate tracing and recall if required.

Consumer Preference for Genetically Modified Halal Yogurt Drinks

Directory of Open Access Journals (Sweden)

Siti Hasnah Hassan

2017-06-01

Full Text Available Consumers worldwide have reacted negatively to food products made from genetically modified (GM ingredients. This study strives to understand the importance placed by consumers on the features of a product when purchasing halal yogurt drinks with GM or non GM ingredient along with the level of antioxidants, price, flavor and Halal certification from JAKIM. In addition, their attitudes towards genetically modified foods, in general, and their purchase intention towards genetically modified yo- gurt drinks, in particular, were also determined. Experimental design using a convenience sampling was used; 120 eligible responses were received from the study using three types of yogurt drinks. The research findings showed that nutrition was deemed as being the most important product feature that influenced the decision in purchasing yogurt drinks, followed by freshness, price, flavor, variety, and origin. Furthermore, it was found that respondents presented a neutral attitude and purchase intention towards genetically modified yogurt drinks. The recommendations to market practitioners, research limitations, as well as suggestions for future studies are also discussed.

Additives for cement compositions based on modified peat

Energy Technology Data Exchange (ETDEWEB)

Kopanitsa, Natalya, E-mail: kopanitsa@mail.ru; Sarkisov, Yurij, E-mail: sarkisov@tsuab.ru; Gorshkova, Aleksandra, E-mail: kasatkina.alexandra@gmail.com; Demyanenko, Olga, E-mail: angel-n@sibmail.com [Tomsk State University of Architecture and Building, 2, Solyanaya sq., Tomsk, 634003 (Russian Federation)

2016-01-15

High quality competitive dry building mixes require modifying additives for various purposes to be included in their composition. There is insufficient amount of quality additives having stable properties for controlling the properties of cement compositions produced in Russia. Using of foreign modifying additives leads to significant increasing of the final cost of the product. The cost of imported modifiers in the composition of the dry building mixes can be up to 90% of the material cost, depending on the composition complexity. Thus, the problem of import substitution becomes relevant, especially in recent years, due to difficult economic situation. The article discusses the possibility of using local raw materials as a basis for obtaining dry building mixtures components. The properties of organo-mineral additives for cement compositions based on thermally modified peat raw materials are studied. Studies of the structure and composition of the additives are carried out by physicochemical research methods: electron microscopy and X-ray analysis. Results of experimental research showed that the peat additives contribute to improving of cement-sand mortar strength and hydrophysical properties.

Engineering research, development and technology

International Nuclear Information System (INIS)

1994-05-01

The mission of the Engineering Research, Development, and Technology Program at Lawrence Livermore National Laboratory (LLNL) is to develop the technical staff, tools, and facilities needed to support current and future LLNL programs. The efforts are guided by a dual-benefit research and development strategy that supports Department of Energy missions, such as national security through nuclear deterrence and economic competitiveness through partnerships with U.S. industry. This annual report, organized by thrust area, describes the activities for the fiscal year 1993. The report provides timely summaries of objectives, methods, and results from nine thrust areas for this fiscal year: Computational Electronics and Electromagnetics; Computational Mechanics; Diagnostics and Microelectronics; Fabrication Technology; Materials Science and Engineering; Power Conversion Technologies; Nondestructive Evaluation; Remote Sensing, Imaging, and Signal Engineering; and Emerging Technologies. Separate abstracts were prepared for 47 papers in this report

Researchers use Modified CRISPR Systems to Modulate Gene Expression on a Genomic Scale

Science.gov (United States)

Cancer Target Discovery and Development Network (CTD2) researchers at the University of California, San Francisco, developed a CRISPR system that can regulate both gene repression and activation with fewer off-target effects.

Development and verification of remote research environment based on 'Fusion research grid'

International Nuclear Information System (INIS)

Iba, Katsuyuki; Ozeki, Takahisa; Totsuka, Toshiyuki; Suzuki, Yoshio; Oshima, Takayuki; Sakata, Shinya; Sato, Minoru; Suzuki, Mitsuhiro; Hamamatsu, Kiyotaka; Kiyono, Kimihiro

2008-01-01

'Fusion research grid' is a concept that unites scientists and let them collaborate effectively against their difference in time zone and location in a nuclear fusion research. Fundamental technologies of 'Fusion research grid' have been developed at JAEA in the VizGrid project under the e-Japan project at the Ministry of Education, Culture, Sports, Science and Technology (MEXT). We are conscious of needs to create new systems that assist researchers with their research activities because remote collaborations have been increasing in international projects. Therefore we have developed prototype remote research environments for experiments, diagnostics, analyses and communications based on 'Fusion research grid'. All users can access these environments from anywhere because 'Fusion research grid' does not require a closed network like Super SINET to maintain security. The prototype systems were verified in experiments at JT-60U and their availability was confirmed

Development through science: The IAEA research contract programme

International Nuclear Information System (INIS)

Benson Wiltschegg, T.; Gillen, V.

1991-01-01

The IAEA strives to stimulate the growth of science in developing countries by assuring that the IAEA and the scientific communities of developed and developing countries share their knowledge and experience. If the assistance provided is well organized and in keeping with the needs of developing countries it can make the crucial difference in sustainable development. This booklet provides a survey of the historical development of the IAEA's Research Contract Programme and outlines the aims and achievements of selected Co-ordinated Research Programmes. A complete listing of Co-ordinated Research Programmes is provided

Development of generic quality indicators for patient-centered cancer care by using a RAND modified Delphi method

NARCIS (Netherlands)

Uphoff, Eleonora P. M. M.; Wennekes, Lianne; Punt, Cornelis J. A.; Grol, Richard P. T. M.; Wollersheim, Hub C. H.; Hermens, Rosella P. M. G.; Ottevanger, Petronella B.

2012-01-01

Despite growing attention to patient-centered care, the needs of cancer patients are not always met. Using a RAND modified Delphi method, this study aimed to systematically develop evidence-based indicators, to be used to measure the quality of patient-centered cancer care as a first step toward

Research and development program 1985

International Nuclear Information System (INIS)

1984-01-01

In this report the research and development program of the GSI Darmstadt is described. It concerns heavy ion reactions, nuclear structure studies, exotic nuclei, nuclear theory, atomic collisions with heavy ions, atomic spectroscopy, the interaction of heavy ions with matter, atomic theory, biological studies with heavy ions, nuclear track techniques, UNILAC developments, acquisition of experimental data, and the development of new accelerators, ion sources, targets, and detectors. (HSI) [de

Development of reconstitution technique of irradiated specimens. 3. Report for FY 1995 and FY 1996 on JAERI-IHI cooperated research program (joint research)

Energy Technology Data Exchange (ETDEWEB)

Nishiyama, Yutaka; Fukaya, Kiyoshi; Onizawa, Kunio; Suzuki, Masahide [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Nakamura, Terumi; Kaihara, Shoichiro; Yoshida, Kazuo; Sato, Akira

1998-10-01

The cooperated research between Japan Atomic Energy Research Institute and Ishikawajima-Harima Heavy Industries Co., Ltd. on the development of reconstitution technique of irradiated reactor pressure vessel surveillance specimens has been performed from FY 1993. In FY 1993-1994, the method of surface activated joining (SAJ) was applied to reconstitution of Charpy impact specimens. Some verification tests using unirradiated reactor pressure vessel plate materials have shown that SAJ is feasible for a reconstitution technique, in particular, owing to low joining temperature. The present paper reports the results of the cooperated research performed in FY 1995-1996. To improve the quality of the SAJ, the configuration of the end tab surface to be joined with the insert material was modified. The torque measured during joining was also introduced in joining parameters. A nondestructive inspection, temperature measurements in the specimens during joining were performed. The effect of joining on Charpy impact properties was discussed. For practical application of the technique to irradiated specimens, we confirmed that the impact specimens with joining interface gave rise to no failure at the joining position during impact test after neutron irradiation. (author)

Tip-modified Propellers

DEFF Research Database (Denmark)

Andersen, Poul

1999-01-01

The paper deals with tip-modified propellers and the methods which, over a period of two decades, have been applied to develop such propellers. The development is driven by the urge to increase the efficiency of propellers and can be seen as analogous to fitting end plates and winglets to aircraft...... propeller, have efficiency increases of a reasonable magnitude in both open-water and behind-ship conditions....

UCLA accelerator research and development

International Nuclear Information System (INIS)

Cline, D.B.

1992-01-01

This progress report covers work supported by the above DOE grant over the period November 1, 1991 to July 31, 1992. The work is a program of experimental and theoretical studies in advanced particle accelerator research and development for high energy physics applications. The program features research at particle beam facilities in the United States and includes research on novel high power sources, novel focussing systems (e.g. plasma lens), beam monitors, novel high brightness, high current gun systems, and novel flavor factories in particular the φ Factory

78 FR 66992 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Science.gov (United States)

2013-11-07

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical... the panels of the Joint Biomedical Laboratory Research and Development and Clinical Science Research..., behavioral, and clinical science research. The panel meetings will be open to the public for approximately...

75 FR 57833 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Science.gov (United States)

2010-09-22

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical... the panels of the Joint Biomedical Laboratory Research and Development and Clinical Science Research... Crowne Plaza Clinical Research Program December 3, 2010 *VA Central Office Mental Hlth & Behav Sci-A...

78 FR 22622 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Science.gov (United States)

2013-04-16

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical... the panels of the Joint Biomedical Laboratory Research and Development and Clinical Science Research... biomedical, behavioral and clinical science research. The panel meetings will be open to the public for...

Study on effective modifiers for damaging salts in mortar

NARCIS (Netherlands)

Granneman, S.J.C.; Ruiz-Agudo, E.; Lubelli, B.A.; Hees, R.P.J. van; Rodgriguez-Navarro

2014-01-01

The use of crystallization modifiers for the prevention or mitigation of salt crystallization damage has recently received a lot of research interest in the field of building conservation. However, the use of crystallization modifiers mixed in a lime-based mortar, is still a very new field of

Development of a nationwide consensus syllabus of palliative medicine for undergraduate medical education in Japan: a modified Delphi method.

Science.gov (United States)

Kizawa, Yoshiyuki; Tsuneto, Satoru; Tamba, Kaichiro; Takamiya, Yusuke; Morita, Tatsuya; Bito, Seiji; Otaki, Junji

2012-07-01

There is currently no consensus syllabus of palliative medicine for undergraduate medical education in Japan, although the Cancer Control Act proposed in 2007 covers the dissemination of palliative care. To develop a nationwide consensus syllabus of palliative medicine for undergraduate medical education in Japan using a modified Delphi method. We adopted the following three-step method: (1) a workshop to produce the draft syllabus; (2) a survey-based provisional syllabus; (3) Delphi rounds and a panel meeting (modified Delphi method) to produce the working syllabus. Educators in charge of palliative medicine from 63% of the medical schools in Japan collaborated to develop a survey-based provisional syllabus before the Delphi rounds. A panel of 32 people was then formed for the modified Delphi rounds comprising 28 educators and experts in palliative medicine, one cancer survivor, one bereaved family member, and two medical students. The final consensus syllabus consists of 115 learning objectives across seven sections as follows: basic principles; disease process and comprehensive assessment; symptom management; psychosocial care; cultural, religious, and spiritual issues; ethical issues; and legal frameworks. Learning objectives were categorized as essential or desirable (essential: 66; desirable: 49). A consensus syllabus of palliative medicine for undergraduate medical education was developed using a clear and innovative methodology. The final consensus syllabus will be made available for further dissemination of palliative care education throughout the country.

Research in Review. Malnutrition and Children's Development.

Science.gov (United States)

Stevens, Joseph H., Jr.; Baxter, Delia H.

1981-01-01

Indicates how various degrees of malnutrition affect children's development. Reviews research conducted in several developing countries and the United States, and describes the nutritional status of children in the United States. Implications for nutrition programs, research and policy formation are pointed out. (Author/RH)

7 CFR 947.47 - Research and development.

Science.gov (United States)

2010-01-01

... Secretary, may provide for the establishment of marketing research and development projects designed to... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 947.47 Section 947.47 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing...

76 FR 19188 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Science.gov (United States)

2011-04-06

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical... the panels of the Joint Biomedical Laboratory Research and Development and Clinical Science Research.... Neurobiology-D June 10, 2011 Crowne Plaza DC/Silver Spring. Clinical Research Program June 13, 2011 VA Central...

75 FR 23847 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Science.gov (United States)

2010-05-04

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical... panels of the Joint Biomedical Laboratory Research and Development and Clinical Science Research and... & Behav Sci-A June 7, 2010 L'Enfant Plaza Hotel. Clinical Research Program June 9, 2010 *VA Central Office...

Life Cycle Impact Assessment Research Developments and Needs

Science.gov (United States)

Life Cycle Impact Assessment (LCIA) developments are explained along with key publications which record discussions which comprised ISO 14042 and SETAC document development, UNEP SETAC Life Cycle Initiative research, and research from public and private research institutions. It ...

Fusion reactor materials research in China

International Nuclear Information System (INIS)

Qian Jiapu

1994-10-01

The fusion materials research in China is introduced. Many kinds of structural materials (such as Ti-modified stainless steel, ferritic steel, HT-9, HT-7, oxide dispersion strengthening ferritic steel), tritium breeders (lithium, Li 2 O, γ-LiAlO 2 ) and plasma facing materials (PFMs) (graphite with TiC and SiC coatings) have been developed or being developed. A systematic research activities on irradiation effects, compatibility, plasma materials interaction, thermal shock during disruption, tritium production, release and permeation, neutron multiplication in Be and Pb, etc. have been performed. The research activities are summarized and some experimental results are also given

Faculty Development for Fostering Clinical Reasoning Skills in Early Medical Students Using a Modified Bayesian Approach.

Science.gov (United States)

Addy, Tracie Marcella; Hafler, Janet; Galerneau, France

2016-01-01

Clinical reasoning is a necessary skill for medical students to acquire in the course of their education, and there is evidence that they can start this process at the undergraduate level. However, physician educators who are experts in their given fields may have difficulty conveying their complex thought processes to students. Providing faculty development that equips educators with tools to teach clinical reasoning may support skill development in early medical students. We provided faculty development on a modified Bayesian method of teaching clinical reasoning to clinician educators who facilitated small-group, case-based workshops with 2nd-year medical students. We interviewed them before and after the module regarding their perceptions on teaching clinical reasoning. We solicited feedback from the students about the effectiveness of the method in developing their clinical reasoning skills. We carried out this project during an institutional curriculum rebuild where clinical reasoning was a defined goal. At the time of the intervention, there was also increased involvement of the Teaching and Learning Center in elevating the status of teaching and learning. There was high overall satisfaction with the faculty development program. Both the faculty and the students described the modified Bayesian approach as effective in fostering the development of clinical reasoning skills. Through this work, we learned how to form a beneficial partnership between a clinician educator and Teaching and Learning Center to promote faculty development on a clinical reasoning teaching method for early medical students. We uncovered challenges faced by both faculty and early learners in this study. We observed that our faculty chose to utilize the method of teaching clinical reasoning in a variety of manners in the classroom. Despite obstacles and differing approaches utilized, we believe that this model can be emulated at other institutions to foster the development of clinical

Federal Plan for Advanced Networking Research and Development

Data.gov (United States)

Networking and Information Technology Research and Development, Executive Office of the President — In the four decades since Federal research first enabled computers to send and receive data over networks, U.S. government research and development R and D in...

Publications | Page 50 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 491 - 500 of 6341 ... Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. ... ​Does the unequal distribution of technological resources and available data sets threaten the developing world's participation in the open data ...

Background for the research and subsequent developments in the research program

International Nuclear Information System (INIS)

This report summarizes the historical background for the research and its subsequent development. Various aspects of the research were supported by the USAEC, ERDA, CCNY, CUNY, MHMC and personally by the principal investigator

Is genetically modified crop the answer for the next green revolution?

Science.gov (United States)

Basu, Saikat Kumar; Dutta, Madhuleema; Goyal, Aakash; Bhowmik, Pankaj Kumar; Kumar, Jitendra; Nandy, Sanjib; Scagliusi, Sandra Mansun; Prasad, Rajib

2010-01-01

Post-green revolution advances made in biotechnology paved the way of cultivating the high-yielding, stress and disease resistant genetically modified (GM) varieties of wheat, rice, maize cotton and several other crops. The recent rapid commercialization of the genetically modified crops in Asia, Americas and Australia indicates the potentiality of this new technology. GM crops give higher yields and are rich in nutritional values containing vitamins and minerals and can thus can help to alleviate hunger and malnutrition of the growing population in the under developed and developing countries. It could also be possible to develop more biotic and abiotic stress resistant genotypes in these crops where it was difficult to develop due to the unavailability of genes of resistance in the crossing germplasms. However, further research and investigations are needed to popularize the cultivation of these crops in different parts of the world. This review provides an insight of the impact of GM crops on contemporary agriculture across the past few decades, traces its' history across time, highlights new achievements and breakthroughs and discusses the future implication of this powerful technology in the coming few decades.

Challenges of Research and Human Capital Development in Nigeria

Science.gov (United States)

Chikwe, Christian K.; Ogidi, Reuben C.; Nwachukwu, K.

2015-01-01

The paper discussed the challenges of research and human capital development in Nigeria. Research and human capital development are critical to the development of any nation. Research facilitates human capital development. A high rating in human capital development indices places a country among the leading countries of the world. The paper…

Supplier Development Literature Review and Key Future Research Areas

Directory of Open Access Journals (Sweden)

Muddassir Ahmed

2012-10-01

Full Text Available The purpose of this paper is to develop a Supplier Development (SD literature framework and identify the main focus areas in SD research. To this end, a comprehensive review of the existing SD academic literature has been undertaken, which includes 62 research papers. These papers are classified according to their research content and the research methodology employed. A comprehensive list of future research areas is also presented. Thus, this paper will also briefly explore proposed future research. The review of the SD literature presented here identifies the following main areas of focus: Supplier Development Activities, Practices and Success Factors; Direct or Indirect Supplier Development; Supplier Development as a Reactive or Strategic Process; Supplier Development in a Lean Six Sigma & SME context.

Nuclear Research and Development in the AEC Era

International Nuclear Information System (INIS)

Mongkolnavin, R.

2014-01-01

In 2015, South East Asian Countris are entering into the social, economic and security partnership. Nuclear Research and Development undoubtedly has important roles in all three pillars. Nuclear applications that are being realised in the region ranges from energy, mrdical to agricultural application.In this new era of cooperation, we are seeking for technologies that lead to solution to improve our ways of living. As all other research and development nuclear research has been carried out in all countries in the region. However, it does have its critiques on safety issues based on people capability in the region. In order to make progress in research and development, human resource development is the key fundamental to its sucess. An experience of regional collaboration in developing pulsed neutron souurce is presented as an example. The research had been revived though collaoration of different research laboratories within ASEAN countries with support of Asian African Assosiation for Plasma Training (AAAPT). The 'low cost research theme' has fundamentally set up a platform for more future advanced research for fusion and for local industrial applications. It also increases experimental and theoretical research awareness among new generations that could be carried out in local laboratories. A device such as UNU-ICPT Plasma Focus has been explored, and it has been built, studied; both theoretical and experimental; and used for many different kind of applications.

Development research: The environmental challenge

International Nuclear Information System (INIS)

Winpenny, J.T.

1991-01-01

This book represents papers from a 1990 conference 'The environment, Development and Economic Research'. The focus of the book is the environmental and natural resource use problems, though economic development is a strong co-theme. Chapters cover the following topic areas: international issues; macroeconomic policies; natural resource degradation; urban problems; social dimensions; bio-diversity; energy; economic valuation

A Modified Electrostatic Adsorption Apparatus for Latent Fingerprint Development on Unfired Cartridge Cases.

Science.gov (United States)

Xu, Jingyang; Zhang, Ziyuan; Zheng, Xiaochun; Bond, John W

2017-05-01

Visualization of latent fingerprints on metallic surfaces by the method of applying electrostatic charging and adsorption is considered as a promising chemical-free method, which has the merit of nondestruction, and is considered to be effective for some difficult situations such as aged fingerprint deposits or those exposed to environmental extremes. In fact, a portable electrostatic generator can be easily accessible in a local forensic technology laboratory, which is already widely used in the visualization of footwear impressions. In this study, a modified version of this electrostatic apparatus is proposed for latent fingerprint development and has shown great potential in visualizing fingerprints on metallic surfaces such as cartridge cases. Results indicate that this experimental arrangement can successfully develop aged latent fingerprints on metal surfaces, and we demonstrate its effectiveness compared with existing conventional fingerprint recovery methods. © 2016 American Academy of Forensic Sciences.

The AECL research and development program

International Nuclear Information System (INIS)

Hart, R.G.; Woods, A.D.B.

1980-02-01

The research and development program of the Atomic Energy of Canada Research Company is briefly described. Goals and objectives are emphasized, some recent highlights are given and the importance of technology transfer is discussed. A short representative bibliography is included. (auth)

Research and Development Costs in Retail Trade

Directory of Open Access Journals (Sweden)

Radojko LUKIC

2016-12-01

Full Text Available Research and development expenses are crucial business performance factors for all enterprises, including trading companies. The size and structure of these expenses depend largely on the nature of a company’s activities. Due to such importance and specificity, the research focus of this article is on R&D expenses in trading companies with particular emphasis on retail companies. Their share in the sales revenue of trading companies is increasingly important and determined by many factors, such as innovation, size, location, product categories, and others. Due to varying intensity of influence of these and other factors, research and development expenses in commercial companies differ among countries, trade types (wholesale, retail, wholesale and retail, retail formats (store types and product categories. Understanding the factors of these differences is important for efficient management of research and development costs in trade, particularly retail companies. They are the focus of research in this work.

Chemically modified graphene based supercapacitors for flexible and miniature devices

Science.gov (United States)

Ghosh, Debasis; Kim, Sang Ouk

2015-09-01

Rapid progress in the portable and flexible electronic devises has stimulated supercapacitor research towards the design and fabrication of high performance flexible devices. Recent research efforts for flexible supercapacitor electrode materials are highly focusing on graphene and chemically modified graphene owing to the unique properties, including large surface area, high electrical and thermal conductivity, excellent mechanical flexibility, and outstanding chemical stability. This invited review article highlights current status of the flexible electrode material research based on chemically modified graphene for supercapacitor application. A variety of electrode architectures prepared from chemically modified graphene are summarized in terms of their structural dimensions. Novel prototypes for the supercapacitor aiming at flexible miniature devices, i.e. microsupercapacitor with high energy and power density are highlighted. Future challenges relevant to graphene-based flexible supercapacitors are also suggested. [Figure not available: see fulltext.

Genetically Modified Products – Contradictions and Challenges

OpenAIRE

Rodica Pamfilie; Lavinia-Alexandra Cristescu

2011-01-01

This paper aims to identify the perception that consumers have about GM products, also taking into consideration the evolution of consumption and production of products based on genetically modified organisms. Therefore, the paper presents both aspects to clarify the concept of genetically modified organism (GMO issues such as typology, national or international regulations regarding this area) and global market development of genetically modified organisms, evolution which is presented by st...

Cuba | IDRC - International Development Research Centre

International Development Research Centre (IDRC) Digital Library (Canada)

Researchers developed a way for community members to track mosquito ... government, and business, they bring concrete and innovative development ideas to ... areas such as maternal and child health, and sustainable water management.

7 CFR 922.45 - Marketing research and development.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Marketing research and development. 922.45 Section 922... GROWN IN DESIGNATED COUNTIES IN WASHINGTON Order Regulating Handling Research § 922.45 Marketing... the establishment of marketing research and development projects designed to assist, improve, or...

Program Leader | IDRC - International Development Research Centre

International Development Research Centre (IDRC) Digital Library (Canada)

Leads in the identification of the overall development research ... Ensures that a regional perspective is brought to bear on program planning at the PI and ... The incumbent is the manager of the Program Initiative program and team and as such: ... projects between Canadian and developing country researchers; and; When ...

Ecotribology research developments

CERN Document Server

2016-01-01

This book presents resent research advances in the area of eco-triobology. In the last years, eco-tribology or environmentally friendly tribology has gained increasing importance in sustainable engineering. Environmentally acceptable tribological practices save resources by optimizing product usage and reducing energy. This book covers current developments in all areas covered by the term eco-tribology, including biomimetics surfaces, control of friction and wear, environmental aspects of lubrication and surface modification techniques as well as tribological aspects of green applications, such wind-power turbines or solar panels.

Characterization of radiation modified κ-carrageenan oligomers for bio-based materials development

International Nuclear Information System (INIS)

Abad, Lucille V.; Relleve, Lorna S.; Aranilla, Charito T.; Racadio, Darwin T.; Dela Rosa, Alumanda M.

2011-01-01

κ-carrageenan oligomers are known to have several biological activities such as anti-HIV, anti-herpes, antitumor and antioxidant properties. Recent progress in the development of radiation modified κ-carrageenan has resulted in new applications such as plant growth promoter, radiation dose indicator and hydrogels for wound dressing. This presentation would touch on the changes in chemical structure, gelation and conformational transition behavior and molecular size of κ-carrageenan at doses from 0 to 200 kGy and would be correlated to these functions for the development of bio-based materials. Chemical and spectral analyses were carried out using UV-Vis spectroscopy, FT-IR spectroscopy, NMR spectroscopy, reducing sugar analysis, free sulfate and carboxylic acid analysis. The chemical and spectral analyses of the radiolytic products indicated increasing reducing sugars, carbonyl, carboxylic acids, and sulfates with increasing doses which reached a maximum level at a certain dose depending on the irradiation condition. Values were very much lower in solid irradiation (in vacuum and in air) as compared to aqueous irradiation. NMR data also revealed an intact structure of the oligomer irradiated at 100 kGy in the specific fraction that contains an Mw = (3-10) kDa. κ-carrageenan oligomers exhibited antioxidant properties as determined by hydroxyl radical scavenging activity, reducing power and DPPH radical scavenging capacity assay. The degree of oxidative inhibition increased with increasing dose which can be attributed to higher reducing sugar. Dynamic light scattering (DLS) experiments showed that a dose of up to 50 kGy, sol-gelation transition was still observed. Beyond 50 kGy, no gelation took place, instead appearance of fast relax-carrageenan mode in characteristic decay time function was observed at doses of (75-150) kGy. Optimum peak intensity was found at 100 kGy (mol wt. 5-10 kDa) which coincides with the optimum plant growth promoter effect in κ

7 CFR 923.45 - Marketing research and development.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Marketing research and development. 923.45 Section 923... CHERRIES GROWN IN DESIGNATED COUNTIES IN WASHINGTON Order Regulating Handling Research § 923.45 Marketing... the establishment of marketing research and development projects designed to assist, improve, or...

Migration and Rural Development: Selected Topics for Teaching and Research. FAO Economic and Social Development Paper 3.

Science.gov (United States)

Du Guerny, J.

In their role as change agents, rural development personnel often modify the environment in which they are operating when they introduce different technology, institutional modifications, etc. Because these actions can change the relationship between the rural population and its habitat and may encourage out-migration or in-migration, rural…

Propagation and storing of light in optically modified atomic media

International Nuclear Information System (INIS)

Zaremba, Jaroslaw

2010-01-01

Coherent interactions of laser light with atomic ensembles allow one to modify dispersive properties of a medium and lead to new optical phenomena. Studies of the controlled light propagation and storing in such media have recently become a dynamically developing field of research motivated both by the fundamental character of the processes and by potential applications. This article briefly reviews basic theoretical approach to the dynamics of the propagation of laser pulses in optically modified media. The method and the physical processes are discussed that allow one to slow down the group velocity of laser pulse to zero (stopping of light), to transfer the state of a light pulse to atomic coherences and to restore the pulse. The interpretation of these phenomena in the formalism of dark-state polaritons is presented. Examples of possible coherent manipulations on a stored light are also discussed.

Propagation and storing of light in optically modified atomic media

Energy Technology Data Exchange (ETDEWEB)

Zaremba, Jaroslaw, E-mail: zaremba@fizyka.iomk.p [Institute of Physics Nicolaus Copernicus University ul. Grudziadzka 5/7 87 100 Torun (Poland)

2010-03-01

Coherent interactions of laser light with atomic ensembles allow one to modify dispersive properties of a medium and lead to new optical phenomena. Studies of the controlled light propagation and storing in such media have recently become a dynamically developing field of research motivated both by the fundamental character of the processes and by potential applications. This article briefly reviews basic theoretical approach to the dynamics of the propagation of laser pulses in optically modified media. The method and the physical processes are discussed that allow one to slow down the group velocity of laser pulse to zero (stopping of light), to transfer the state of a light pulse to atomic coherences and to restore the pulse. The interpretation of these phenomena in the formalism of dark-state polaritons is presented. Examples of possible coherent manipulations on a stored light are also discussed.

Debating the future of genetically modified plants - bridging knowledge dimensions. A technology foresight study

DEFF Research Database (Denmark)

Borch, Kristian; Rasmussen, Birgitte

2003-01-01

Rapid developments in, and the controversial nature of, biotechnology call for communication, networks, partnerships, and collaboration in research, not just among researchers but also between researchers and research “users” in industry, government, andelsewhere. Technological foresight appears...... to offer a coordinating method for developing and strengthening those linkages. To test this, a technological foresight study was performed on genetically modified (GM) crop technology in the Danish context. Thebackground to the study was the conflict and intense debate in Denmark over applications of gene...... public audience finds it hard to comprehend this type of debate. The study pursues the notion thatpublic dialogue can act as a driver of future applications in the technological domain, specifically GM crops. The study concluded with a stakeholder workshop that revealed three key issues that might...

Developing Action Research for Developing Teachers in Kosovo

Directory of Open Access Journals (Sweden)

Eda Vula

2015-10-01

Full Text Available This study explores the perception of student teachers on their role as researchers and the impact of action research in their professional development. The study involves the master level student teachers of the Faculty of Education at the University of Prishtina in Kosovo. Qualitative data collected through reflective writing, open-ended questionnaires and research reports developed by student teachers were analyzed through the inductive method. The study suggests that teacher research has a major impact not only on the improvement of teaching practices and increasing student achievement, but also on increasing the collaboration among peers and fostering a new culture where teachers assume their responsibilities to apply action research in their own classrooms as a tool for classroom transformation. Teacher education and school context are crucial in this matter and the need arises to avoid viewing the development of teacher research as an isolated activity.Keywords: Action research, professional development, student teacher, environmentÖzBu araştırma, öğrenci öğretmenlerin araştırmacı rollerini algılamalarını ve profesyonel gelişimlerinde eylem araştırmaların etkisini incelemektedir. Araştırma, Priştine Üniversitesi Eğitim Fakültesi’nde yüksek lisans düzeyinde olan öğrenci öğretmenleri kapsamaktadır. Öğrenciler tarafından yapılan yansıtıcı yazılar, açık uçlu soru formları ve araştırma raporlarından toplanan nitel veriler tümevarım yöntemi aracılığıyla incelenmiştir. Araştırma, öğretmen araştırmalarının, sadece öğretim uygulamalarının geliştirilmesine ve öğrenci başarısının yükseltilmesine değil, aynı zamanda yaşıtlar arası işbirliğini arttırma ve öğretmenlerin sınıfı dönüştürme aracı olarak kendi sınıflarında eylem araştırmasını uygulama sorumluluğunu yeni bir kültür olarak teşvik etmeye önemli bir etkisinin olduğunu ortaya koymaktad

Software Development as Music Education Research

Science.gov (United States)

Brown, Andrew R.

2007-01-01

This paper discusses how software development can be used as a method for music education research. It explains how software development can externalize ideas, stimulate action and reflection, and provide evidence to support the educative value of new software-based experiences. Parallels between the interactive software development process and…

Educational Development and Developmental Research in Mathematics Education

NARCIS (Netherlands)

Gravemeijer, K.P.E.

1994-01-01

In light of anticipated changes in mathematics education, an alternative for the well- known "research-development-diffusion" model is presented. It is based on an integration of curriculum research and design embedded in "educational development." In this context curriculum development is described

Management of research and development project

International Nuclear Information System (INIS)

Go, Seok Hwa; Hong Jeong Yu; Hyun, Byeong Hwan

2010-12-01

This book introduces summary on management of research and development project, prepare of research and development with investigation and analysis of paper, patent and trend of technology, structure of project, management model, management of project, management of project range, management of project time, management of project cost, management of project goods, management of project manpower, management of communication, management of project risk, management of project supply, management of outcome of R and D, management of apply and enroll of patent and management of technology transfer.

Managing scientists leadership strategies in research and development

CERN Document Server

Sapienza, Alice M

1995-01-01

Managing Scientists Leadership Strategies in Research and Development Alice M. Sapienza "I found ...this book to be exciting ...Speaking as someone who has spent 30 years grappling with these issues, I certainly would be a customer." -Robert I. Taber, PhD Senior Vice President of Research & Development Synaptic Pharmaceutical Corporation In today's climate of enormous scientific and technologic competition, it is more crucial than ever that scientists involved in research and development be managed well. Often trained as individual researchers, scientists can find integration into teams difficult. Managers, from both scientific and nonscientific backgrounds, who are responsible for these teams frequently find effective team building a long and challenging process. Managing Scientists offers strategies for fostering communication and collaboration among scientists. It shows how to build cohesive, productive, and focused teams to succeed in the competitive research and development marketplace. This book wil...

Laboratory Directed Research and Development Program

Energy Technology Data Exchange (ETDEWEB)

Ogeka, G.J.

1991-12-01

Today, new ideas and opportunities, fostering the advancement of technology, are occurring at an ever-increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of these new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and which develops new fundable'' R D projects and programs. At Brookhaven National Laboratory (BNL), one such method is through its Laboratory Directed Research and Development (LDRD) Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor achieving and maintaining staff excellence, and a means to address national needs, with the overall mission of the Department of Energy (DOE) and the Brookhaven National Laboratory. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals, and presentations at meetings and forums.

Rutting resistance of asphalt mixture with cup lumps modified binder

Science.gov (United States)

Shaffie, E.; Hanif, W. M. M. Wan; Arshad, A. K.; Hashim, W.

2017-11-01

Rutting is the most common pavement distress in pavement structures which occurs mainly due to several factors such as increasing of traffic volume, climatic conditions and also due to construction design errors. This failure reduced the service life of the pavement, reduced driver safety and increase cost of maintenance. Polymer Modified Binder has been observed for a long time in improving asphalt pavement performance. Research shows that the use of polymer in bituminous mix not only improve the resistance to rutting but also increase the life span of the pavement. This research evaluates the physical properties and rutting performance of dense graded Superpave-designed HMA mix. Two different types of dense graded Superpave HMA mix were developed consists of unmodified binder mix (UMB) and cup lumps rubber (liquid form) modified binder mix (CLMB). Natural rubber polymer modified binder was prepared from addition of 8 percent of cup lumps into binder. Results showed that all the mixes passed the Superpave volumetric properties criteria which indicate that these mixtures were good with respect to durability and flexibility. Furthermore, rutting results from APA rutting test was determined to evaluate the performance of these mixtures. The rutting result of CLMB demonstrates better resistance to rutting than those prepared using UMB mix. Addition of cup lumps rubber in asphalt mixture was found to be significant, where the cup lumps rubber has certainly improves the binder properties and enhanced its rutting resistance due to greater elasticity offered by the cup lumps rubber particles. It shows that the use of cup lumps rubber can significantly reduce the rut depth of asphalt mixture by 41% compared to the minimum rut depth obtained for the UMB mix. Therefore, it can be concluded that the cup lumps rubber is suitable to be used as a modifier to modified binder in order to enhance the properties of the binder and thus improves the performance of asphalt mixes.

Operational Research(ers in development: Growing a new generation of operational researchers

Directory of Open Access Journals (Sweden)

I Durbach

2013-06-01

Full Text Available This paper explores the theme of training operational research (OR practitioners in South Africa by critically evaluating a Masters program in Operational Research in Development (ORD, launched in 2005 at the University of Cape Town. This program was specifically focused on applying OR to the problems of the developing world in general and Africa in particular. We describe the program and review the practical work undertaken by students participating in the program. Topics range widely across domains including health (antimalarial drug resistance; poverty (food banking; governance (NGO management structures and monitoring of local government performance and sustainable livelihoods (spaza shop operations. We use the review to highlight strengths and weaknesses of the program, as well as challenges faced in the OR education in South Africa at a postgraduate level.

Digital Three-Dimensional Automation of the Modified Huddart and Bodenham Scoring System for Patients With Cleft Lip and Palate.

Science.gov (United States)

Ma, Xinhui; Martin, Catherine; McIntyre, Grant; Lin, Ping; Mossey, Peter

2017-07-01

The modified Huddart and Bodenham scoring system assesses maxillary arch constriction and surgical outcomes in cleft lip and palate. This project automates modified Huddart and Bodenham scoring using three-dimensional digital models. Development of a novel software tool. The design, construction, development, and testing of the system was carried out at Dundee Dental Hospital. Subjects with cleft lip and palate. A plug-in has been developed using an open three-dimensional development platform: Rhinoceros, version 5 ( http://www.rhino3d.co.uk ). Users select cusps on mandibular and maxillary teeth on three-dimensional digital models. A three-dimensional cubic spline generates a mandibular curve, and a best-fit horizontal mandibular reference plane is produced using a least-squares method. Horizontal distances projected from the shortest three-dimensional distances were subsequently calculated between the maxillary cusps and the mandibular curve to calculate the modified Huddart and Bodenham score. Automatic scoring of digital models using the modified Huddart and Bodenham system produces similar results to manual scoring. By standardizing outcome assessment in cleft care, multicenter comparisons for audit and research can be simplified, allowing centers throughout the world to upload three-dimensional digital models or intraoral scans of the dental arches for remote scoring. Thereafter, these data can feed back into the global database on orofacial clefting as part of the World Health Organization's international collaborative "Global Burden of Disease" research project for craniofacial anomalies. The automated system facilitates quicker and more reliable outcome assessments by minimizing human errors.

New Product Development and Business Strategy of Research and Development

International Nuclear Information System (INIS)

Lee, Sun Cheol

1998-05-01

The contents of this book are new product development strategy of the top business, commercialization and new product development, development case analysis and framework of new product development, investigation strategy for idea of new product development, case analysis of research as development and goal of new product development, case analysis and planning and management for new product development, innovative item development and technical management against confusion, the map for determination procedure of development, strategy of market and goods and development strategy cases in leading company.

Consent Documentation and the Accessibility of Research Results in International Development Research

Directory of Open Access Journals (Sweden)

Erika Malich

2018-02-01

Full Text Available This case study touches on issues that may arise in international development research, with reflections based on experiences conducting research in Peru. The two issues to be discussed are that of cultural differences in the consent documentation process, and ensuring that the benefits of research flow back to research participants.

Present status of research and development on underground disposal

International Nuclear Information System (INIS)

1994-11-01

Power Reactor and Nuclear Fuel Development Corporation published the technical report 'Research and development of the formation disposal of high level radioactive waste' 1991 in 1992, summarizing the results of the research and development of the formation disposal which have been advanced by dividing into three parts, that is, the investigation and research of geological environment conditions, the research and development of disposal technologies, and the research on the performance evaluation. Based on the subjects pointed out during the process of making the technical report, the results of evaluation by the state, and the opinions of those concerned, the efforts are exerted toward the second summarization expected in about 2000. By informing the present state of the research and development, in order to accept the criticism and advice, this book was published. The way of thinking and the method of advancing of the research and development of formation disposal, the present state of the research on geological environment conditions, disposal technologies and the performance evaluation are described. Also the present state of the research on stratum science in Tono and Kamaishi mines and others is reported. (K.I.)

Present status of research and development on underground disposal

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-11-01

Power Reactor and Nuclear Fuel Development Corporation published the technical report `Research and development of the formation disposal of high level radioactive waste` 1991 in 1992, summarizing the results of the research and development of the formation disposal which have been advanced by dividing into three parts, that is, the investigation and research of geological environment conditions, the research and development of disposal technologies, and the research on the performance evaluation. Based on the subjects pointed out during the process of making the technical report, the results of evaluation by the state, and the opinions of those concerned, the efforts are exerted toward the second summarization expected in about 2000. By informing the present state of the research and development, in order to accept the criticism and advice, this book was published. The way of thinking and the method of advancing of the research and development of formation disposal, the present state of the research on geological environment conditions, disposal technologies and the performance evaluation are described. Also the present state of the research on stratum science in Tono and Kamaishi mines and others is reported. (K.I.).

77 FR 64598 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Science.gov (United States)

2012-10-22

... DEPARTMENT OF VETERANS AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical...) that the panels of the Joint Biomedical Laboratory Research and Development and Clinical Science... areas of biomedical, behavioral and clinical science research. The panel meetings will be open to the...

76 FR 79273 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Science.gov (United States)

2011-12-21

... Science Research and Development Services Scientific Merit Review Board Panel for Eligibility, Notice of... and Clinical Science Research and Development Services Scientific Merit Review Board will meet on... medical specialties within the general areas of biomedical, behavioral, and clinical science research. The...

Publications | Page 79 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 781 - 790 of 6372 ... Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the results of our funded research, and offer free training materials to guide researchers and institutions. Want more? Explore outputs from more ...

Assessing the efficacy of a modified assertive community-based treatment programme in a developing country

Directory of Open Access Journals (Sweden)

Botha Ulla A

2010-09-01

Full Text Available Abstract Background A number of recently published randomized controlled trials conducted in developed countries have reported no advantage for assertive interventions over standard care models. One possible explanation could be that so-called "standard care" has become more comprehensive in recent years, incorporating some of the salient aspects of assertive models in its modus operandi. Our study represents the first randomised controlled trial assessing the effect of a modified assertive treatment service on readmission rates and other measures of outcome in a developing country. Methods High frequency service users were randomized into an intervention (n = 34 and a control (n = 26 group. The control group received standard community care and the active group an assertive intervention based on a modified version of the international model of assertive community treatment. Study visits were conducted at baseline and 12 months with demographic and illness information collected at visit 1 and readmission rates documented at study end. Symptomatology and functioning were measured at both visits using the PANSS, CDSS, ESRS, WHO-QOL and SOFAS. Results At 12 month follow-up subjects receiving the assertive intervention had significantly lower total PANSS (p = 0.02 as well as positive (p Conclusions Our results indicate that assertive interventions in a developing setting where standard community mental services are often under resourced can produce significant outcomes. Furthermore, these interventions need not be as expensive and comprehensive as international, first-world models in order to reduce inpatient days, improve psychopathology and overall levels of functioning in patients with severe mental illness.

Quality assurance activities in nuclear research and development

Energy Technology Data Exchange (ETDEWEB)

Suzuki, Mitsutoshi; Ishikawa, Hirohisa [Japan Nuclear Cycle Development Inst., Tokai, Ibaraki (Japan)

2001-03-01

A case study into the quality management system of the Associated Nuclear Research Association has been performed with reference to the fast breeder reactor (FBR) cycle and high-level waste management (HLWM) research fields. The Japan Nuclear Cycle Development Institute's major research and development projects are in these fields. Progress in the quality management system for research subjects has been compared and analyzed by comparing with both the development level of individual projects and the external environment. Computer-assisted performance assessment systems analysis (CAPASA) in high-level waste management is described as a practical example. (author)

Generation of genetically modified mice using CRISPR/Cas9 and haploid embryonic stem cell systems

Directory of Open Access Journals (Sweden)

Li-Fang JIN

2016-07-01

Full Text Available With the development of high-throughput sequencing technology in the post-genomic era, researchers have concentrated their efforts on elucidating the relationships between genes and their corresponding functions. Recently, important progress has been achieved in the generation of genetically modified mice based on CRISPR/Cas9 and haploid embryonic stem cell (haESC approaches, which provide new platforms for gene function analysis, human disease modeling, and gene therapy. Here, we review the CRISPR/Cas9 and haESC technology for the generation of genetically modified mice and discuss the key challenges in the application of these approaches.

76 FR 24974 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

Science.gov (United States)

2011-05-03

... Science Research and Development Services Scientific Merit Review Board; Notice of Meeting Amendment The... and Clinical Science Research and Development Services Scientific Merit Review Board have been..., behavioral and clinical science research. The panel meetings will be open to the public for approximately one...

Development research in countries in transition: Introduction | IDRC ...

International Development Research Centre (IDRC) Digital Library (Canada)

2011-01-11

Jan 11, 2011 ... Development research is risky work — and never riskier than in conditions of political, economic, and social transition. But transitions in developing countries can open radically new opportunities for research that informs political change and relieves poverty, while advancing development that is both ...

Developing a plasma focus research training system for the fusion energy age

International Nuclear Information System (INIS)

Lee, S.

2014-01-01

The 3 kJ UNU/ICTP Plasma Focus Facility is the most significant device associated with the AAAPT (Asian African Association for Plasma Training). In original and modified/upgraded form it has trained generations of plasma focus (PF) researchers internationally, producing many PhD theses and peer-reviewed papers. The Lee Model code was developed for the design of this PF. This code has evolved to cover all PF machines for design, interpretation and optimization, for derivation of radiation scaling laws; and to provide insights into yield scaling limitations, radiative collapse, speed-enhanced and current-stepped PF variants. As example of fresh perspectives derivable from this code, this paper presents new results on energy transfers of the axial and radial phases of generalized PF devices. As the world moves inexorably towards the Fusion Energy Age it becomes ever more important to train plasma fusion researchers. A recent workshop in Nepal shows that demand for such training continues. Even commercial project development consultants are showing interest. We propose that the AAAPT-proven research package be upgraded, by modernizing the small PF for extreme modes of operation, switchable from the typical strong-focus mode to a slow-mode which barely pinches, thus producing a larger, more uniform plasma stream with superior deposition properties. Such a small device would be cost-effective and easily duplicated, and have the versatility of a range of experiments from intense multi-radiation generation and target damage studies to superior advanced-materials deposition. The complementary code is used to reference experiments up to the largest existing machine. This is ideal for studying machine limitations and scaling laws and to suggest new experiments. Such a modernized versatile PF machine complemented by the universally versatile code would extend the utility of the PF experience; so that AAAPT continues to provide leadership in pulsed plasma research training in

Research Skills Development in Higher Education Students

Science.gov (United States)

Bergamini, Tiziana Priede; Navarro, Cristina Lopez-Cozar

2014-01-01

This case study presents the development of a research project in a third-year undergraduate course, Family Business Administration. The research project aimed at promoting research skills in students. The authors formed working groups of no more than six students, and each group had to select an original research topic after conducting a…

Endogenous Reference Genes and Their Quantitative Real-Time PCR Assays for Genetically Modified Bread Wheat (Triticum aestivum L.) Detection.

Science.gov (United States)

Yang, Litao; Quan, Sheng; Zhang, Dabing

2017-01-01

Endogenous reference genes (ERG) and their derivate analytical methods are standard requirements for analysis of genetically modified organisms (GMOs). Development and validation of suitable ERGs is the primary step for establishing assays that monitoring the genetically modified (GM) contents in food/feed samples. Herein, we give a review of the ERGs currently used for GM wheat analysis, such as ACC1, PKABA1, ALMT1, and Waxy-D1, as well as their performances in GM wheat analysis. Also, we discussed one model for developing and validating one ideal RG for one plant species based on our previous research work.

76 FR 44648 - Research, Engineering and Development Advisory Committee

Science.gov (United States)

2011-07-26

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development....S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development.... Name: Research, Engineering & Development Advisory Committee. Time and Date: September 21, 2011--9 a.m...

Institutional research and development, FY 1988

International Nuclear Information System (INIS)

1988-01-01

The Laboratory's Institutional Research and Development (IR and D) Program was established in 1984 to foster exploratory work to advance science and technology, disciplinary research to develop innovative solutions to support our national defense and energy missions. In FY 1988, the IR and D Program was funded by a 2% assessment on the Laboratory's operating budget. Our policy is to use these funds for researching innovative ideas in LLNL's areas of expertise and for developing new areas of expertise that we perceive to be in the national interest. The technical and scientific accomplishments of each project and of each institute funded this year are presented in this report. The projects were selected because they are expected to advance research in important areas that are too basic or too time consuming to be funded by the developmental programs or because they are somewhat risky projects that have the promise of high payoff. We are continually reappraising the IR and D Program. In particular, we seek new candidates for the Director's Initiatives, and we constantly reassess the work in progress. Each year, we make adjustments to further the Laboratory's policy of using the IR and D Program to fund innovative ideas with high potential for enhancing programmatic activities of national importance

The Impact of Tax Incentives on Research and Development

Directory of Open Access Journals (Sweden)

Petr Svoboda

2017-01-01

Full Text Available The goal of this article is to analyze the impact of tax incentives on research and development and compare its effectiveness to direct government support of research and development. The analysis is based on regression analysis, which compares effect of tax incentives for research and development and direct government support (as percentage of GDP in 28 countries of OECD in 2013 on innovative effectiveness of these countries measured by number of registered triadic patent families per billion GDP in the same year. Results suggest that tax incentives are more effective form of research and development support than direct government funding. Research also revealed interesting case of Switzerland’s research and development performance backed by almost none government support, which should be subject to future study.

The sustainable development thematic in the research groups

Directory of Open Access Journals (Sweden)

Maria Cristina Comunian Ferraz

2007-11-01

Full Text Available The technological innovation brought for the debate the question of the sustainable technological development. The article presents an entirety of theoretical reflections on the science, technology and sustainable development themes and to aim the contributions of the Information Science, while interdisciplinary science, with respect to the understanding of the sustainable development. With basis in this reference it was carried through the investigation of descriptive exploratory nature with quanti-qualitative boarding, having as main objective to identify the presence of the sustainable development thematic in research groups of the UFSCar registered in cadastre in the National Directory of Research Groups of the CNPq. The results had shown that the sustainable development thematic is present in eleven researchgroups of the UFSCar distributed in different knowledge areas. Comparing the data gotten with the research groups of the country that had participated of 2004 Census of the National Directory of Research Groups of the CNPq it was verified that it has similarity between both the data. In accordance with scientific literature, confirms that the sustainable development thematic is interdisciplinar and that the knowledge production of the research groups is result to know articulated in some of the knowledge areas.

Accountability in public health units: using a modified nominal group technique to develop a balanced scorecard for performance measurement.

Science.gov (United States)

Robinson, Victoria A; Hunter, Duncan; Shortt, Samuel E D

2003-01-01

Little attention has been paid to the need for accountability instruments applicable across all health units in the public health system. One tool, the balanced scorecard was created for industry and has been successfully adapted for use in Ontario hospitals. It consists of 4 quadrants: financial performance, outcomes, customer satisfaction and organizational development. The aim of the present study was to determine if a modified nominal group technique could be used to reach consensus among public health unit staff and public health specialists in Ontario about the components of a balanced scorecard for public health units. A modified nominal group technique consensus method was used with the public health unit staff in 6 Eastern Ontario health units (n=65) and public health specialists (n=18). 73.8% of the public health unit personnel from all six health units in the eastern Ontario region participated in the survey of potential indicators. A total of 74 indicators were identified in each of the 4 quadrants: program performance (n=44); financial performance (n=11); public perceptions (n=11); and organizational performance (n=8). The modified nominal group technique was a successful method of incorporating the views of public health personnel and specialists in the development of a balanced scorecard for public health.

Valuing Professional Development Components for Emerging Undergraduate Researchers

Science.gov (United States)

Cheung, I.

2015-12-01

In 2004 the Hatfield Marine Science Center (HMSC) at Oregon State University (OSU) established a Research Experience for Undergraduates (REU) program to engage undergraduate students in hands-on research training in the marine sciences. The program offers students the opportunity to conduct research focused on biological and ecological topics, chemical and physical oceanography, marine geology, and atmospheric science. In partnership with state and federal government agencies, this ten-week summer program has grown to include 20+ students annually. Participants obtain a background in the academic discipline, professional development training, and research experience to make informed decisions about careers and advanced degrees in marine and earth system sciences. Professional development components of the program are designed to support students in their research experience, explore career goals and develop skills necessary to becoming a successful young marine scientist. These components generally include seminars, discussions, workshops, lab tours, and standards of conduct. These componentscontribute to achieving the following professional development objectives for the overall success of new emerging undergraduate researchers: Forming a fellowship of undergraduate students pursuing marine research Stimulating student interest and understanding of marine research science Learning about research opportunities at Oregon State University "Cross-Training" - broadening the hands-on research experience Exploring and learning about marine science careers and pathways Developing science communication and presentation skills Cultivating a sense of belonging in the sciences Exposure to federal and state agencies in marine and estuarine science Academic and career planning Retention of talented students in the marine science Standards of conduct in science Details of this program's components, objectives and best practices will be discussed.

40 CFR 270.65 - Research, development, and demonstration permits.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Research, development, and... Special Forms of Permits § 270.65 Research, development, and demonstration permits. (a) The Administrator may issue a research, development, and demonstration permit for any hazardous waste treatment facility...

77 FR 14462 - Research, Engineering and Development Advisory Committee

Science.gov (United States)

2012-03-09

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development....S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development.... Name: Research, Engineering & Development Advisory Committee. Time and Date: April 18, 2012--9:30 a.m...

78 FR 16357 - Research, Engineering and Development Advisory Committee

Science.gov (United States)

2013-03-14

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development... hereby given of a meeting of the FAA Research, Engineering and Development (R,E&D) Advisory Committee. Name: Research, Engineering & Development Advisory Committee. Time and Date: April 24--8:30 a.m. to 4...

Developing electrodes chemically modified with cucurbit[6]uril to detect 3,4-methylenedioxymethamphetamine (MDMA) by voltammetry

International Nuclear Information System (INIS)

Tadini, Maraine Catarina; Balbino, Marco Antonio; Eleoterio, Izabel Cristina; Siqueirade Oliveira, Laura; Dias, Luis Gustavo; Jean-François Demets, Grégoire; Firmino de Oliveira, Marcelo

2014-01-01

Graphical abstract: - Highlights: • A new stand in forensic chemistry. • Voltammetric method for the determination of MDMA in seized samples. • A new voltammetric sensor for MDMA. - Abstract: This study aimed to develop an electrode chemically modified with cucurbit[6]uril to detect 3,4-methylenedioxymethamphetamine (MDMA), the main active principle of ecstasy samples, by voltammetry. We modified the electrode surface with a film containing cucurbit[6]uril, Nafion, and methanol, using the dip coating or the spin coating technique. During analysis, we employed an electrochemical cell with a conventional three-electrode system and KCl solution (0.1 mol L −1 ) as the supporting electrolyte. We conducted cyclic voltammetry at concentrations ranging from 4.2 × 10 −6 to 4.8 × 10 −5 mol L −1 . We also accomplished scanning electron microscopy, to investigate the structural behavior of the film that originated on the electrode surface. We obtained the following results when we used dip coating to prepare the modified electrode: standard deviation (SD) = 0.024 μA, limit of detection (LOD) = 3.5 μmol L −1 , limit of quantification (LOQ) = 11.7 μmol L −1 , and amperometric sensitivity (m) = 20.9 × 10 3 μA L mol −1 . As for spin coating, we obtained SD = 0.024 μA, LOD = 2.7 μmol L −1 , LOQ = 9.1 μmol L −1 and m = 25.9 × 10 3 μA mol L −1 . These are very promising data: the modified electrode is more sensitive than the conventional glassy carbon electrode under the studied experimental conditions

48 CFR 970.35 - Research and development contracting.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Research and development... SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Major System Acquisition 970.35 Research and development contracting. ...

Modifiable Determinants of Obesity in Native Hawaiian and Pacific Islander Youth.

Science.gov (United States)

Braden, Katherine W; Nigg, Claudio R

2016-06-01

In the United States, obesity continues to be a major public health concern. Obesity disproportionately affects Native Hawaiian and Other Pacific Islanders (NHOPI) who demonstrate alarming rates of obesity and its related chronic conditions. However, little is known about the causes of obesity for this group. Given the modest effects of individual-level obesity treatments, identifying the most impactful determinants that can be modified to prevent or reduce obesity in NHOPI youth is critical to the development of interventions that best meet the needs of this population. A systematic review was conducted in PubMed, with additional expert-recommended articles identified through the Hawai'i Initiative for Childhood Obesity Research and Education (HICORE) research database, to evaluate the current body of research on modifiable determinants or correlates of obesity in NHOPI youth. Of an initial pool of 471 articles, 60 articles were read in full and 14 articles were selected for inclusion in the qualitative synthesis. Utilizing an ecological framework to identify gaps in the literature and suggest areas for future research, findings from this review indicate that early life and contextual factors-namely, infant-feeding mode, geographic location, and education-appear to play an important role in obesity in NHOPI youth. However, more research is needed, particularly pre-birth cohort studies evaluating the effects of prenatal and early life risk factors, studies on the sociocultural influences on obesity-related psychosocial factors and health behaviors, as well as the influence of environmental and policy-level variables.

Metallurgical Characterization of Reduced Activation Martensitic Steel F-82H Modified

International Nuclear Information System (INIS)

Fernandez, P.; Lapena, J.; Lancha, A.M.; Gomez-Briceno, D.; Schirra, M.

1999-12-01

During 1995-1998 within of research and development programs on reduced ferritic/martensitic steels for fusion, metallurgical characterization of 8Cr-2WVTa steel, denominated F-28H modified, have been carried out. The work has focused on studying the microstructural and mechanical (tensile, creep, low cycle fatigue and charpy) characteristics of as-received state and aged material in the temperature range 300 degree centigrade to 600 degree centigrade for periods up to 5000 h. (Author) 45 refs

Development of a Hydrogen Peroxide Sensor Based on Screen-Printed Electrodes Modified with Inkjet-Printed Prussian Blue Nanoparticles

Directory of Open Access Journals (Sweden)

Stefano Cinti

2014-08-01

Full Text Available A sensor for the simple and sensitive measurement of hydrogen peroxide has been developed which is based on screen printed electrodes (SPEs modified with Prussian blue nanoparticles (PBNPs deposited using piezoelectric inkjet printing. PBNP-modified SPEs were characterized using physical and electrochemical techniques to optimize the PBNP layer thickness and electroanalytical conditions for optimum measurement of hydrogen peroxide. Sensor optimization resulted in a limit of detection of 2 × 10−7 M, a linear range from 0 to 4.5 mM and a sensitivity of 762 μA∙mM–1∙cm–2 which was achieved using 20 layers of printed PBNPs. Sensors also demonstrated excellent reproducibility (<5% rsd.

Enhanced photoelectrochemical and photocatalytic activity of WO3-surface modified TiO2 thin film

Science.gov (United States)

Qamar, Mohammad; Drmosh, Qasem; Ahmed, Muhammad I.; Qamaruddin, Muhammad; Yamani, Zain H.

2015-02-01

Development of nanostructured photocatalysts for harnessing solar energy in energy-efficient and environmentally benign way remains an important area of research. Pure and WO3-surface modified thin films of TiO2 were prepared by magnetron sputtering on indium tin oxide glass, and photoelectrochemical and photocatalytic activities of these films were studied. TiO2 particles were <50 nm, while deposited WO3 particles were <20 nm in size. An enhancement in the photocurrent was observed when the TiO2 surface was modified WO3 nanoparticles. Effect of potential, WO3 amount, and radiations of different wavelengths on the photoelectrochemical activity of TiO2 electrodes was investigated. Photocatalytic activity of TiO2 and WO3-modified TiO2 for the decolorization of methyl orange was tested.

Genetically Modified Organisms

Directory of Open Access Journals (Sweden)

Claro Llaguno

2001-06-01

Full Text Available Recent reports have brought to public attention concerns about Bt corn and genetically modified organisms (GMO in general. The timing, it seems, is most appropriate considering two related developments early this year: the final approval of the Cartagena Protocol on Biosafety in Montreal on January 29, 2001, and the OECD Edinburgh Conference on GM food safety last February 28- March 1, 2001. The protocol makes clear that GMOs include all living modified organisms (LMO defined as "any living organism that possesses a novel combination of genetic material obtained through the use of modern biotechnology". This includes seeds, live fish, and other organisms intentionally obtained for release to the environment. It would seem that the common understanding about GMOs as referring to farm-to-table products is perforce expanded to embrace genetically modified farm animals and aquatic resources. Being a trade agreement, the Montreal accord primarily deals with the safety issues related to the transboundary movement of LMOs around the globe. The OECD conference on the other hand, called for an international body "to address all sides of the GM debate" in response to the public outcry, particularly in Western Europe, regarding the risks the new products pose to human health and the environment. Some points of contention, which remain unresolved, include issues such as whether countries should be allowed to develop their own GM food based on their needs, and whether a global moratorium on GMOs and mandatory labeling should be enforced worldwide.

A Newly Improved Modified Method Development and Validation of Bromofenac Sodium Sesquihydrate in Bulk Drug Manufacturing

OpenAIRE

Sunil Kumar Yelamanchi V; Useni Reddy Mallu; I. V Kasi Viswanath; D. Balasubramanyam; G. Narshima Murthy

2016-01-01

The main objective of this study was to develop a simple, efficient, specific, precise and accurate newly improved modified Reverse Phase High Performance Liquid Chromatographic Purity (or) Related substance method for bromofenac sodium sesquihydrate active pharmaceuticals ingredient dosage form. Validation of analytical method is the confirmation by examination and the provision of objective evidence that the particular requirements for a specific intended use are fulfilled as per ICH, USP...

7 CFR 930.48 - Research, market development and promotion.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Research, market development and promotion. 930.48... Order Regulating Handling Research, Market Development and Promotion § 930.48 Research, market development and promotion. The Board, with the approval of the Secretary, may establish or provide for the...

40 CFR 258.4 - Research, development, and demonstration permits.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Research, development, and...) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS General § 258.4 Research, development, and... State may issue a research, development, and demonstration permit for a new MSWLF unit, existing MSWLF...

17 CFR 256.188 - Research, development, or demonstration expenditures.

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Research, development, or... COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 4. Deferred Debits § 256.188 Research, development, or... of all expenditures for research, development or demonstration undertaken by or sponsored through the...

77 FR 54648 - Research, Engineering and Development Advisory Committee

Science.gov (United States)

2012-09-05

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development....S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development...: Research, Engineering & Development Advisory Committee. TIME AND DATE: September 26, 2012--9 a.m. to 4 p.m...

76 FR 12404 - Research, Engineering and Development Advisory Committee

Science.gov (United States)

2011-03-07

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering and Development....S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development...: Research, Engineering & Development Advisory Committee. Time and Date: April 20, 2011--9:30 a.m. to 4 p.m...

75 FR 14243 - Research, Engineering And Development Advisory Committee

Science.gov (United States)

2010-03-24

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Research, Engineering And Development....S.C. App. 2), notice is hereby given of a meeting of the FAA Research, Engineering and Development...: Research, Engineering & Development Advisory Committee. Time and Date: April 21, 2010--9 a.m. to 5 p.m...

2016 Federal Cybersecurity Research and Development Strategic Plan

Data.gov (United States)

Networking and Information Technology Research and Development, Executive Office of the President — As part of the Presidents Cybersecurity National Action Plan (CNAP), the Administration released the 2016 Federal Cybersecurity Research and Development Strategic...

The prospects for the research on chemical modifiers of cancer treatment

International Nuclear Information System (INIS)

Jin Yizun

2002-01-01

The current clinical statue of chemical modifiers of cancer treatment is described. It should enable greater enhancement ratios to be attained clinically. To search for less toxic and more potent sensitizers for radiotherapy and chemotherapy will be improved the cancer treatment. Phase I, II and III clinical trials with TPZ, one of the bioreductive drugs, has shown the benefit to patients with cancer

7 CFR 927.47 - Research and development.

Science.gov (United States)

2010-01-01

... provide for the establishment of production and post-harvest research, or marketing research and... 7 Agriculture 8 2010-01-01 2010-01-01 false Research and development. 927.47 Section 927.47 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing...

48 CFR 27.408 - Cosponsored research and development activities.

Science.gov (United States)

2010-10-01

....408 Cosponsored research and development activities. (a) In contracts involving cosponsored research... objectives of the contract. Since the purpose of the cosponsored research and development, the legitimate... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cosponsored research and...

40 CFR 720.36 - Exemption for research and development.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Exemption for research and development... chemical substance is manufactured or imported only in small quantities solely for research and development... associated with research and development activities, of any risk to health, identified under paragraph (b) of...

DEVELOPMENT AND RESEARCH OF THE MODIFIED WHITE METAL MATERIAL WITH THE PURPOSE OF ITS USE AT REPAIR OF HEAVY-LOADED BEARINGS OF SLIPPING

Directory of Open Access Journals (Sweden)

A. V. Alifanov

2012-01-01

Full Text Available The paper shows that wear resistance of new modified babbit material (MBM is by an order of magnitude higher than that of the Б83 State Standard 1320-74 standard babbit material. Therefore, the latter can be recommended for restoration of sliding bearings that are used in gascompressor units.

Developing a performance measurement system for public research centres

Directory of Open Access Journals (Sweden)

Masella, C.

2012-01-01

Full Text Available This study aims at developing a performance measurement system (PMS for research and development (R&D activities carried out by public research centres. Public research institutions are characterized by multiple stakeholders with different needs, and the management of R&D activities requires balancing the multiple goals of different stakeholders. This characteristic is a key issue in the process of construction of the PMS. Empirical evidence is provided by an Italian public research centre, where the researchers carried out a project aimed to develop a PMS following action research principles. This project gave the possibility to researchers to interact with different stakeholders and integrate their different information needs in a comprehensive set of key performance indicators (KPIs. As a result, multidimensional framework for measuring R&D performance in a public research centre is proposed and a set of Key Performance Indicators is developed, suggesting implications for academics and practitioners.

Tertiary Educational Institutions for Teaching, Research and Development

Science.gov (United States)

Amoo, Sikiru A.

2014-01-01

This paper examines the quality of teaching and research in developing human resources to facilitate the development of tertiary education in the nation. It discusses the challenges and the roles of research in higher education. The author argues that the combination of content and pedagogical knowledge could help to develop human resources for…

Research and development in power plant engineering

International Nuclear Information System (INIS)

Riedle, K.; Taud, R.

2001-01-01

Research and development are a bridge for visions that are escorted to a successful market introduction. Also in power plant engineering, research and development are a lever with which the product power plant, its technology and processes can be adapted to the quickly changing future market. In the overview given by this paper, therefore at first the development boosters and targets are outlined from the viewpoint of the market; then the available technology portfolio is addressed in a concise way. Targets for the development can be seen from the support programmes of the governments. Before a preview is given, some development topics from the point of view of the manufacturer are introduced. (orig.) [de

Nepal | IDRC - International Development Research Centre

International Development Research Centre (IDRC) Digital Library (Canada)

Plant breeding research in the 1980s and 1990s led to more productive cereals, such as finger millet and barley. Other efforts have strengthened farmers' ability to conserve the genetic diversity of their traditional crops. An improved rice variety — developed collaboratively by farmers and researchers — was introduced in ...

Hydropower research and development

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-03-01

This report is a compilation of information on hydropower research and development (R and D) activities of the Federal government and hydropower industry. The report includes descriptions of on-going and planned R and D activities, 1996 funding, and anticipated future funding. Summary information on R and D projects and funding is classified into eight categories: fish passage, behavior, and response; turbine-related; monitoring tool development; hydrology; water quality; dam safety; operations and maintenance; and water resources management. Several issues in hydropower R and D are briefly discussed: duplication; priorities; coordination; technical/peer review; and technology transfer/commercialization. Project information sheets from contributors are included as an appendix.

The Development and Validation of the GMOAS, an Instrument Measuring Secondary School Students' Attitudes towards Genetically Modified Organisms

Science.gov (United States)

Herodotou, Christothea; Kyza, Eleni A.; Nicolaidou, Iolie; Hadjichambis, Andreas; Kafouris, Dimitris; Terzian, Freda

2012-01-01

Genetically modified organisms (GMOs) is a rapidly evolving area of scientific innovation and an issue receiving global attention. Attempts to devise usable instruments that assess people's attitudes towards this innovation have been rare and non-systematic. The aim of this paper is to present the development and validation of the genetically…

Publications | Page 76 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 751 - 760 of 6335 ... IDRC works with developing-country researchers and institutions to build local capacity through funding, knowledge sharing, and training. Through books, articles, research ... Caribbean health : diversity in local food production to combat obesity (restricted access). Led by researchers from McGill ...

Managing Research Libraries in Developing Economy | Ahmed ...

African Journals Online (AJOL)

This paper discusses managing research libraries in developing economy. The concepts of special libraries, funding of research libraries, the need for training and retraining of library staff and resources sharing networking were highlighted. The paper recommends that research Institutes need to re-order their priorities ...

27 CFR 25.196 - Removals for research, development or testing.

Science.gov (United States)

2010-04-01

... Analysis, Research, Development Or Testing § 25.196 Removals for research, development or testing. (a) A brewer may remove beer, without payment of tax, for use in research, development, or testing (other than... or brewery operations. Beer may be removed for research, development or testing in packages or in...

[Application of a modified culturing method for lymphocytes in cytogenetic research].

Science.gov (United States)

Gao, Chaoxian; Hui, Changye; Zhang, Wen; Guo, Yan; Li, Limei; Chen, Yuting; Zhang, Liuzhuo; Yang, Xinyue; Huang, Xianqing

2016-08-01

To establish a modified method for microculturing whole human blood for cytogenetic analysis. A novel tube rack was designed to overcome the drawbacks of directly culturing the cells within centrifuge tubes. The fractions of human plasma, human serum and two commercial fetal bovine sera were analyzed with 15% sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The influence of adding 0%, 5%, 10%, 15%, 20%, 25% and 30% autologous plasma to the culture on lymphocyte transformation rate and mitotic index (MI) was examined. The SDS-PAGE analysis showed a significant difference between commercial fetal bovine sera, and that the components of human plasma were similar to those of fetal bovine serum. The value of MI in lymphocyte was evidently increased along with addition of autologous plasma. However, this has exerted no significant effect on the transformation rate. With the addition of 10% autologous plasma, the MI value has become much higher than the conventional method. A modified method was established by application of a novel tube inclined rack and optimization of whole blood inoculation. This method is easier and cheaper, and is suitable for application in clinical practice.

Ground-breaking virtual research in product development

DEFF Research Database (Denmark)

Søndergaard, Helle Alsted; Jespersen, Kristina Risom; Buck, Nuka

2008-01-01

MAPP also focuses on virtual reality. In the research project RIPS - the Role of Information Processing in NPD Strategy - a simulation of a product development process was used as a data collection instrument.......MAPP also focuses on virtual reality. In the research project RIPS - the Role of Information Processing in NPD Strategy - a simulation of a product development process was used as a data collection instrument....

Research and Development Conference CIEE Program 1992

Energy Technology Data Exchange (ETDEWEB)

1992-11-01

CIEE`s second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director`s discretionary research, and exploratory research will also be featured in this report.

Research and Development Conference CIEE Program 1992

Energy Technology Data Exchange (ETDEWEB)

1992-01-01

CIEE's second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director's discretionary research, and exploratory research will also be featured in this report.

Modified basin-type solar still

International Nuclear Information System (INIS)

El-Mously, M.K.; El-Ashry, M.Y.; El-Iraqi, M.H.

1981-07-01

A modified basin-type solar still (BTSS) has been developed. The new idea introduced is to re-use the latent heat due to condensation for increasing the temperature of saline water flowing into the device. A new term had been introduced in the balance of equation of conventional BTSS leading to the increase of the efficiency. According to the suggested model, a modified BTSS had been constructed and tested. It is found that the increase in the efficiency is about 14%. (author)

Long Term Field Development of a Surfactant Modified Zeolite/Vapor Phase Bioreactor System for Treatment of Produced Waters for Power Generation

Energy Technology Data Exchange (ETDEWEB)

Lynn Katz; Kerry Kinney; Robert Bowman; Enid Sullivan; Soondong Kwon; Elaine Darby; Li-Jung Chen; Craig Altare

2007-12-31

The main goal of this research was to investigate the feasibility of using a combined physicochemical/biological treatment system to remove the organic constituents present in saline produced water. In order to meet this objective, a physical/chemical adsorption process was developed and two separate biological treatment techniques were investigated. Two previous research projects focused on the development of the surfactant modified zeolite adsorption process (DE-AC26-99BC15221) and development of a vapor phase biofilter (VPB) to treat the regeneration off-gas from the surfactant modified zeolite (SMZ) adsorption system (DE-FC26-02NT15461). In this research, the SMZ/VPB was modified to more effectively attenuate peak loads and to maintain stable biodegradation of the BTEX constituents from the produced water. Specifically, a load equalization system was incorporated into the regeneration flow stream. In addition, a membrane bioreactor (MBR) system was tested for its ability to simultaneously remove the aromatic hydrocarbon and carboxylate components from produced water. The specific objectives related to these efforts included the following: (1) Optimize the performance VPBs treating the transient loading expected during SMZ regeneration: (a) Evaluate the impact of biofilter operating parameters on process performance under stable operating conditions. (b) Investigate how transient loads affect biofilter performance, and identify an appropriate technology to improve biological treatment performance during the transient regeneration period of an SMZ adsorption system. (c) Examine the merits of a load equalization technology to attenuate peak VOC loads prior to a VPB system. (d) Evaluate the capability of an SMZ/VPB to remove BTEX from produced water in a field trial. (2) Investigate the feasibility of MBR treatment of produced water: (a) Evaluate the biodegradation of carboxylates and BTEX constituents from synthetic produced water in a laboratory-scale MBR. (b

Institutional research and development, FY 1988

Energy Technology Data Exchange (ETDEWEB)

1988-01-01

The Laboratory's Institutional Research and Development (IR and D) Program was established in 1984 to foster exploratory work to advance science and technology, disciplinary research to develop innovative solutions to support our national defense and energy missions. In FY 1988, the IR and D Program was funded by a 2% assessment on the Laboratory's operating budget. Our policy is to use these funds for researching innovative ideas in LLNL's areas of expertise and for developing new areas of expertise that we perceive to be in the national interest. The technical and scientific accomplishments of each project and of each institute funded this year are presented in this report. The projects were selected because they are expected to advance research in important areas that are too basic or too time consuming to be funded by the developmental programs or because they are somewhat risky projects that have the promise of high payoff. We are continually reappraising the IR and D Program. In particular, we seek new candidates for the Director's Initiatives, and we constantly reassess the work in progress. Each year, we make adjustments to further the Laboratory's policy of using the IR and D Program to fund innovative ideas with high potential for enhancing programmatic activities of national importance.

Research, regulation and use of genetically modified organisms in agriculture in the developing countries

International Nuclear Information System (INIS)

Sonnino, A.

2008-01-01

Greater international efforts are needed to overcome the political, legislative, economic, financial and social barriers that prevent genetic engineering and its products from fighting hunger and poverty and promoting rural development in the poorest countries [it

Canada | IDRC - International Development Research Centre

International Development Research Centre (IDRC) Digital Library (Canada)

While working with some of the brightest minds in Canada and the world, we've found that knowledge-sharing through networks and regions helps widen the impact of the research we fund. It is through the interaction of ideas, people, and money in worldwide development research and policy that we put our principles into ...

The development of a modified spectral ripple test.

Science.gov (United States)

Aronoff, Justin M; Landsberger, David M

2013-08-01

Poor spectral resolution can be a limiting factor for hearing impaired listeners, particularly for complex listening tasks such as speech understanding in noise. Spectral ripple tests are commonly used to measure spectral resolution, but these tests contain a number of potential confounds that can make interpretation of the results difficult. To measure spectral resolution while avoiding those confounds, a modified spectral ripple test with dynamically changing ripples was created, referred to as the spectral-temporally modulated ripple test (SMRT). This paper describes the SMRT and provides evidence that it is sensitive to changes in spectral resolution.

New laser research and development

International Nuclear Information System (INIS)

Anon.

1976-01-01

New types of lasers must be developed to provide the desired energy per pulse, pulse length, pulse shape, wavelength, and efficiency for laser-fusion applications. This advanced laser research has focused on rare-gas oxides and on Hg 2 excimers

48 CFR 731.773 - Independent research and development costs.

Science.gov (United States)

2010-10-01

... Organizations 731.773 Independent research and development costs. Pending establishment of Government-wide... independent research and development costs. ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Independent research and...

Laboratory Directed Research and Development FY-10 Annual Report

Energy Technology Data Exchange (ETDEWEB)

Dena Tomchak

2011-03-01

The FY 2010 Laboratory Directed Research and Development (LDRD) Annual Report is a compendium of the diverse research performed to develop and ensure the INL's technical capabilities can support the future DOE missions and national research priorities. LDRD is essential to the INL -- it provides a means for the laboratory to pursue novel scientific and engineering research in areas that are deemed too basic or risky for programmatic investments. This research enhances technical capabilities at the laboratory, providing scientific and engineering staff with opportunities for skill building and partnership development.

Safety assessment of foods from genetically modified crops in countries with developing economies.

Science.gov (United States)

Delaney, Bryan

2015-12-01

Population growth particularly in countries with developing economies will result in a need to increase food production by 70% by the year 2050. Biotechnology has been utilized to produce genetically modified (GM) crops for insect and weed control with benefits including increased crop yield and will also be used in emerging countries. A multicomponent safety assessment paradigm has been applied to individual GM crops to determine whether they as safe as foods from non-GM crops. This paper reviews methods to assess the safety of foods from GM crops for safe consumption from the first generation of GM crops. The methods can readily be applied to new products developed within country and this paper will emphasize the concept of data portability; that safety data produced in one geographic location is suitable for safety assessment regardless of where it is utilized. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Proposal for Modified Damage Probability Distribution Functions

DEFF Research Database (Denmark)

Pedersen, Preben Terndrup; Hansen, Peter Friis

1996-01-01

Immidiately following the Estonia disaster, the Nordic countries establishe a project entitled "Safety of Passenger/RoRo Vessels" As part of this project the present proposal for modified damage stability probability distribution functions has been developed. and submitted to "Sub-committee on st......Immidiately following the Estonia disaster, the Nordic countries establishe a project entitled "Safety of Passenger/RoRo Vessels" As part of this project the present proposal for modified damage stability probability distribution functions has been developed. and submitted to "Sub...

What we do | Page 22 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

IDRC supports research in developing countries to create real and lasting change. ... providing developing-country researchers with financial resources, advice, and ... Explore more than 1,000 research projects we've supported over the past ...

What we do | Page 28 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

IDRC supports research in developing countries to create real and lasting change. ... providing developing-country researchers with financial resources, advice, and ... Explore more than 1,000 research projects we've supported over the past ...

The Research and Development of COM-PLY Lumber

Science.gov (United States)

Robert H. McAlister

1989-01-01

Between 1974 and 1986, a Southeastern Station Research Work Unit developed standards for composite studs, joists, and truss lumber and manufactured and demonstrated the materials. Economic feasibility was considered in every stage of research. Further development is left to industry.

Publications | Page 42 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 411 - 420 of 6382 ... Through books, articles, research publications, and studies, we aim to widen the impact of our investment and advance development research. We share the results of our funded ... Evaluation in the Extreme: Research, Impact and Politics in Violently Divided Societies. Over the past two decades, ...

US Army Medical Research and Development Report.

Science.gov (United States)

1979-10-01

RI) US ARMY MEDICAL RESEARCH AND DEVELOPMENT REPORT. Colonel/John Jr DTIC JUL 1 5 1980; A USL &MY MEDICAL BIOENGINEERING RESEARCH AND DEVELOPMENT...pollutants in water or soil . Pollutant by-products and breakdown products in water, air or soil will be isolated, characterized, and quantified. Where...determination of selected low-level pollutants io soil and water. Degradation products and secondary pollutants arising from munitions manufacture or pest

Research on Modified Root-MUSIC Algorithm of DOA Estimation Based on Covariance Matrix Reconstruction

Directory of Open Access Journals (Sweden)

Changgan SHU

2014-09-01

Full Text Available In the standard root multiple signal classification algorithm, the performance of direction of arrival estimation will reduce and even lose effect in circumstances that a low signal noise ratio and a small signals interval. By reconstructing and weighting the covariance matrix of received signal, the modified algorithm can provide more accurate estimation results. The computer simulation and performance analysis are given next, which show that under the condition of lower signal noise ratio and stronger correlation between signals, the proposed modified algorithm could provide preferable azimuth estimating performance than the standard method.

Final report for the Integrated and Robust Security Infrastructure (IRSI) laboratory directed research and development project

Energy Technology Data Exchange (ETDEWEB)

Hutchinson, R.L.; Hamilton, V.A.; Istrail, G.G.; Espinoza, J.; Murphy, M.D.

1997-11-01

This report describes the results of a Sandia-funded laboratory-directed research and development project titled {open_quotes}Integrated and Robust Security Infrastructure{close_quotes} (IRSI). IRSI was to provide a broad range of commercial-grade security services to any software application. IRSI has two primary goals: application transparency and manageable public key infrastructure. IRSI must provide its security services to any application without the need to modify the application to invoke the security services. Public key mechanisms are well suited for a network with many end users and systems. There are many issues that make it difficult to deploy and manage a public key infrastructure. IRSI addressed some of these issues to create a more manageable public key infrastructure.

Technical and safe development features of modern research reactor

International Nuclear Information System (INIS)

Wang Jiaying; Dong Duo

1998-01-01

The development trend of research reactor in the world, and development situation in China are introduced. Up to now, some research reactors have serviced for long time and equipment have aged, not to be satisfied for requirement of science and technology development. New research reactors must been developed. The technical features and safe features of new type research reactor in China, for example: multi-pile utilization, compact core of high flux, high automation level of control, reactor two independent shutdown systems, great coefficient of negative temperature, passive safety systems, reliable residual heat removal system are studied

Development of a cell-seeded modified small intestinal submucosa for urethroplasty

Directory of Open Access Journals (Sweden)

Long Zhang

2016-03-01

Conclusions: A modified 3D porous SIS scaffold seeded with UC and treated with PAA produces better urethroplasty results than cell-seeded untreated SIS scaffolds, or unseeded PAA treated SIS scaffolds.

Assessment of energy research, development, and demonstration priorities for New York State. Interim report. Volume I

Energy Technology Data Exchange (ETDEWEB)

Allentuck, J; Appleman, J; Carroll, T O; Palmedo, P F; Nathans, R

1977-11-01

In compliance with its mandate to accelerate the development and use of energy technologies in furtherance of the state's economic growth and the best interests of its population, the New York State Energy Research and Development Authority (NYSERDA) initiated, in March 1977, an assessment of energy research and development priorities. This report presents a view of the energy supply-demand future of the state, and the ways in which this future can be affected by external contingencies and concerted policies. That view takes into consideration energy supplies that may be available to the state as well as energy demands as they are affected by demographic and economic changes within the state. Also included are the effects of national energy policies and technological developments as they modify both supplies and demands in New York State. Finally, this report proceeds to identify those general technological areas in which the Authority's program can be of greatest potential benefit to the state's social and economic well being. This effort aims at a cost/benefit analysis determination of RD and D priorities. The preliminary analysis thus far indicates these areas as being of highest priority: energy conservation in buildings (promotion and execution of RD and D) and industry; district heating; fuel cell demonstration;solar heating and cooling (analysis, demonstration, and information dissemination); energy-environment interaction (analysis); energy information services; and, in general, the attraction of Federal RD and D programs to the state.

Participatory Research and Development for Sustainable Agriculture ...

International Development Research Centre (IDRC) Digital Library (Canada)

Participatory research and development (PR&D) offers such an inclusive model. ... PR&D concepts and practices for practitioners, researchers, and academic. ... Call for new OWSD Fellowships for Early Career Women Scientists now open.

NGNP Research and Development Status

Energy Technology Data Exchange (ETDEWEB)

David A. Petti

2010-08-01

At the inception of the Next Generation Nuclear Plant (NGNP) project, experts from the Department of Energy (DOE) national laboratories, gas reactor vendors, and universities collaborated to establish technology research and development (R&D) roadmaps. These roadmaps outlined the testing and computational development activities needed to qualify the materials and validate the modeling and simulation tools to be used in the design and safe operation of the NGNP, a helium-cooled, high temperature gas reactor (HTGR).

Development of a Modified Vacuum Cleaner for Lunar Surface Systems

Science.gov (United States)

Toon, Katherine P.; Lee, Steve A.; Edgerly, Rachel D.

2010-01-01

The National Aeronautics and Space Administration (NASA) mission to expand space exploration will return humans to the Moon with the goal of maintaining a long-term presence. One challenge that NASA will face returning to the Moon is managing the lunar regolith found on the Moon's surface, which will collect on extravehicular activity (EVA) suits and other equipment. Based on the Apollo experience, the issues astronauts encountered with lunar regolith included eye/lung irritation, and various hardware failures (seals, screw threads, electrical connectors and fabric contamination), which were all related to inadequate lunar regolith mitigation. A vacuum cleaner capable of detaching, transferring, and efficiently capturing lunar regolith has been proposed as a method to mitigate the lunar regolith problem in the habitable environment on lunar surface. In order to develop this vacuum, a modified "off-the-shelf' vacuum cleaner will be used to determine detachment efficiency, vacuum requirements, and optimal cleaning techniques to ensure efficient dust removal in habitable lunar surfaces, EVA spacesuits, and air exchange volume. During the initial development of the Lunar Surface System vacuum cleaner, systematic testing was performed with varying flow rates on multiple surfaces (fabrics and metallics), atmospheric (14.7 psia) and reduced pressures (10.2 and 8.3 psia), different vacuum tool attachments, and several vacuum cleaning techniques in order to determine the performance requirements for the vacuum cleaner. The data recorded during testing was evaluated by calculating particulate removal, relative to the retained simulant on the tested surface. In addition, optical microscopy was used to determine particle size distribution retained on the surface. The scope of this paper is to explain the initial phase of vacuum cleaner development, including historical Apollo mission data, current state-of-the-art vacuum cleaner technology, and vacuum cleaner testing that has

Research and Development Management System (RDMS)

International Nuclear Information System (INIS)

Mohd Azidi Abdul Rahman; Abdul Muin Abdul Rahman; Sufian Norazam Mohamed Aris; Saaidi Ismail; Mohamad Safuan Sulaiman; Maizura Ibrahim; Hazizi Omar; Roslan Mohd Ali

2010-01-01

Research and Development (R and D) is a main activity carried out at the Malaysian Nuclear Agency particularly in the physical science and nuclear field. The R and D activity that is carried out needs to be managed more efficiently and systematically. Until now all research management activities are carried out manually or semi electronically, beginning from filling in application forms to when the project is completed. Therefore a computerized system is needed in order to manage and monitor R and D projects. The R and D system is capable of giving access information concerning R and D projects which are carried out to users inside and outside the agency. The R and D management system (RDMS) can increase the capability of the Malaysian Nuclear Agency in managing, researching and developing, innovating and inventing technology as well as commercializing the R and D produced. (author)

Outlook on Research in Education for Sustainable Development

Science.gov (United States)

Grasel, Cornelia; Bormann, Inka; Schutte, Kerstin; Trempler, Kati; Fischbach, Robert

2013-01-01

This article provides an overview of current research on Education for Sustainable Development (ESD). It shows a lack of correspondence between ESD research and recent debates in educational research. Research on ESD has established as a field of research with insufficient relations to other fields in educational research. Based on the overview…

Research Award: Innovation for Inclusive Development program

International Development Research Centre (IDRC) Digital Library (Canada)

IDRC CRDI

2011-09-12

Sep 12, 2011 ... students, as well as recent graduates, to enhance their research skills ... experience in development research. ... enable greater understanding of how innovation in the informal ... Innovation and women in the informal sector.

Development and optimization of a modified process for producing the battery grade LiOH: Optimization of energy and water consumption

International Nuclear Information System (INIS)

Grágeda, Mario; González, Alonso; Alavia, Wilson; Ushak, Svetlana

2015-01-01

LiOH·H 2 O is used for preparation of alkaline batteries. The required characteristics of this compound are low levels of impurities and a specific particle size distribution. LiOH·H 2 O is produced from ore and brines. In northern Chile, lithium is produced from brines. This region presents particular desert climate conditions where water and energy are scarce. To help solve this problem, the conventional production process for battery grade LiOH·H 2 O was simulated and a modified process was developed, with an efficient consumption of energy and water, to improve the environmental sustainability of the plant, and greater process yield and product purity. Different configurations of the equipments were studied and for the best configurations the behavior of the modified process at different scenarios were simulated. It was found that the purity is independent of concentration used in feed to thickeners. The process yield increases in average 2.4% for modified process due to recycling operation. In modified process is obtained 28% more product mass, specific energy consumption decreases up to 4.8% and losses of Li/kg of product decreased by 83% compared to conventional process. The water consumption per kg of product in modified process is 1%–6.3%, being lower than in conventional process. The results presented can be considered as guidelines to address the optimization of the industrial process for obtaining the battery grade LiOH. - Highlights: • Water and energy are important resources in any sustainable industrial process. • High purity LiOH·H 2 O is a material for producing of lithium batteries. • Conventional and modified optimized processes for LiOH·H 2 O production were simulated. • Energy and water consumptions decrease for the modified process. • Optimal operational conditions of H 2 O, feed, pressure and energy were established

Advanced Research Reactor Fuel Development

Energy Technology Data Exchange (ETDEWEB)

Kim, C. K.; Park, H. D.; Kim, K. H. (and others)

2006-04-15

RERTR program for non-proliferation has propelled to develop high-density U-Mo dispersion fuels, reprocessable and available as nuclear fuel for high performance research reactors in the world. As the centrifugal atomization technology, invented in KAERI, is optimum to fabricate high-density U-Mo fuel powders, it has a great possibility to be applied in commercialization if the atomized fuel shows an acceptable in-reactor performance in irradiation test for qualification. In addition, if rod-type U-Mo dispersion fuel is developed for qualification, it is a great possibility to export the HANARO technology and the U-Mo dispersion fuel to the research reactors supplied in foreign countries in future. In this project, reprocessable rod-type U-Mo test fuel was fabricated, and irradiated in HANARO. New U-Mo fuel to suppress the interaction between U-Mo and Al matrix was designed and evaluated for in-reactor irradiation test. The fabrication process of new U-Mo fuel developed, and the irradiation test fuel was fabricated. In-reactor irradiation data for practical use of U-Mo fuel was collected and evaluated. Application plan of atomized U-Mo powder to the commercialization of U-Mo fuel was investigated.

Progress in the understanding and utilization of biologic response modifiers in the treatment of uveitis.

Science.gov (United States)

Maleki, Arash; Meese, Halea; Sahawneh, Haitham; Foster, C Stephen

2016-07-01

Uveitis is the third most common cause of blindness in developed countries. Considering the systemic and local complications of long-term corticosteroid therapy and the intolerance due to side effects and ineffectiveness of conventional chemotherapy, use of biologic response modifiers is a reasonable alternative in the treatment of non-infectious uveitis and persistent uveitic macular edema. The majority of the evidence presented here comes from open uncontrolled analyses. Based on these studies, tumor necrosis factor alpha inhibitors, especially infliximab and adalimumab, have been shown to be effective in the treatment of non-infectious uveitis in numerous studies. More research is necessary, particularly multi-center randomized clinical trials, to address the choice of biologic response modifier agent and the length of treatment as we employ biologic response modifiers in different types of uveitis and persistent uveitic macular edema.

The research-based learning development model as a foundation in generating research ideas

Science.gov (United States)

Puspitasari, Poppy; Dika, Johan Wayan; Permanasari, Avita Ayu

2017-09-01

Research Based Learning is learning that requires students to have exploration skills related to their field. By doing so, students are encouraged to create skills in managing the higherorder of abstraction in order to resolve any problems encountered. The study was done to make the schemes and sequences of learning needed by the students in order to help them to explore first ideas for their upcoming thesis. The scheme development resulted in five stages consisting of 1) identifying research journals; 2) track the development of research topics; 3) reviewing research journals; 4) discussing the results of the reviews; and 5) formulating the research topic. Furthermore, the application of 5 the stage receives percentage agreement of students was 85.9%. Therefore, it can be noted that the application of the scheme is definitely a help for students to find research ideas.

Setting a research agenda for progressive multiple sclerosis: the International Collaborative on Progressive MS.

Science.gov (United States)

Fox, Robert J; Thompson, Alan; Baker, David; Baneke, Peer; Brown, Doug; Browne, Paul; Chandraratna, Dhia; Ciccarelli, Olga; Coetzee, Timothy; Comi, Giancarlo; Feinstein, Anthony; Kapoor, Raj; Lee, Karen; Salvetti, Marco; Sharrock, Kersten; Toosy, Ahmed; Zaratin, Paola; Zuidwijk, Kim

2012-11-01

Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify key priority areas for research. A collaborative was convened by volunteer and staff leaders from several MS societies with the mission to expedite the development of effective disease-modifying and symptom management therapies for progressive forms of multiple sclerosis. Through a series of scientific and strategic planning meetings, the collaborative identified and developed new perspectives on five key priority areas for research: experimental models, identification and validation of targets and repurposing opportunities, proof-of-concept clinical trial strategies, clinical outcome measures, and symptom management and rehabilitation. Our conclusions, tackling the impediments in developing therapies for progressive MS will require an integrated, multi-disciplinary approach to enable effective translation of research into therapies for progressive MS. Engagement of the MS research community through an international effort is needed to address and fund these research priorities with the ultimate goal of expediting the development of disease-modifying and symptom-relief treatments for progressive MS.

Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS

Science.gov (United States)

Thompson, Alan; Baker, David; Baneke, Peer; Brown, Doug; Browne, Paul; Chandraratna, Dhia; Ciccarelli, Olga; Coetzee, Timothy; Comi, Giancarlo; Feinstein, Anthony; Kapoor, Raj; Lee, Karen; Salvetti, Marco; Sharrock, Kersten; Toosy, Ahmed; Zaratin, Paola; Zuidwijk, Kim

2012-01-01

Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify key priority areas for research. A collaborative was convened by volunteer and staff leaders from several MS societies with the mission to expedite the development of effective disease-modifying and symptom management therapies for progressive forms of multiple sclerosis. Through a series of scientific and strategic planning meetings, the collaborative identified and developed new perspectives on five key priority areas for research: experimental models, identification and validation of targets and repurposing opportunities, proof-of-concept clinical trial strategies, clinical outcome measures, and symptom management and rehabilitation. Our conclusions, tackling the impediments in developing therapies for progressive MS will require an integrated, multi-disciplinary approach to enable effective translation of research into therapies for progressive MS. Engagement of the MS research community through an international effort is needed to address and fund these research priorities with the ultimate goal of expediting the development of disease-modifying and symptom-relief treatments for progressive MS. PMID:22917690

Series expansion of the modified Einstein Procedure

Science.gov (United States)

Seema Chandrakant Shah-Fairbank

2009-01-01

This study examines calculating total sediment discharge based on the Modified Einstein Procedure (MEP). A new procedure based on the Series Expansion of the Modified Einstein Procedure (SEMEP) has been developed. This procedure contains four main modifications to MEP. First, SEMEP solves the Einstein integrals quickly and accurately based on a series expansion. Next,...

48 CFR 46.309 - Research and development contracts (short form).

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Research and development... REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.309 Research and development contracts... Development (Short Form), in solicitations and contracts for research and development when the clause...

Research in Medicine: Essentials for Developing Countries

Directory of Open Access Journals (Sweden)

Yusuf YAKUPOGULLARI

2014-06-01

Full Text Available (ExtractThe well-being has been the highest topic for humanity throughout the adventure of mankind on the earth. Therefore, extensive efforts have been performed on the science of medicine, and glorious advances have been gained especially in the last two centuries. Research is essential for medicine to develop new therapeutic methods and to monitor the results of the current treatment given to the patient. These are possibly the simplest reasons for investigations in medicine. On the other hand, qualified human resource, research ethics, financial supports, regular data recording and analysis, and publication are important issues for improvement of the medical researches in the developing countries.... 

Research & Development Roadmap for Next-Generation Appliances

Energy Technology Data Exchange (ETDEWEB)

Goetzler, William [Navigant Consulting, Inc., Burlington, MA (United States); Sutherland, Timothy [Navigant Consulting, Inc., Burlington, MA (United States); Foley, Kevin [Navigant Consulting, Inc., Burlington, MA (United States)

2012-03-01

Appliances present an attractive opportunity for near-term energy savings in existing building, because they are less expensive and replaced more regularly than heating, ventilation, and air-conditioning (HVAC) systems or building envelope components. This roadmap targets high-priority research and development (R&D), demonstration and commercialization activities that could significantly reduce residential appliance energy consumption. The main objective of the roadmap is to seek activities that accelerate the commercialization of high-efficiency appliance technologies while maintaining the competitiveness of American industry. The roadmap identified and evaluated potential technical innovations, defined research needs, created preliminary research and development roadmaps, and obtained stakeholder feedback on the proposed initiatives.

Gender | Page 230 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

For research results to improve people's lives, they must reach decision-makers who can use them to develop more effective policies and practices. About 20% of IDRC's project funding in the past year — and the past decade — went to research that aimed to influence policies. To help IDRC-supported research results ...

Publications | Page 25 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 241 - 250 of 6341 ... Journal articles. Papers. Reports. Research in Action. Studies ... Half a year later, on. ... Over the past two decades, the International Development Research Centre (IDRC) has established and subsequently devolved ...

Development Model for Research Infrastructures

Science.gov (United States)

Wächter, Joachim; Hammitzsch, Martin; Kerschke, Dorit; Lauterjung, Jörn

2015-04-01

Research infrastructures (RIs) are platforms integrating facilities, resources and services used by the research communities to conduct research and foster innovation. RIs include scientific equipment, e.g., sensor platforms, satellites or other instruments, but also scientific data, sample repositories or archives. E-infrastructures on the other hand provide the technological substratum and middleware to interlink distributed RI components with computing systems and communication networks. The resulting platforms provide the foundation for the design and implementation of RIs and play an increasing role in the advancement and exploitation of knowledge and technology. RIs are regarded as essential to achieve and maintain excellence in research and innovation crucial for the European Research Area (ERA). The implementation of RIs has to be considered as a long-term, complex development process often over a period of 10 or more years. The ongoing construction of Spatial Data Infrastructures (SDIs) provides a good example for the general complexity of infrastructure development processes especially in system-of-systems environments. A set of directives issued by the European Commission provided a framework of guidelines for the implementation processes addressing the relevant content and the encoding of data as well as the standards for service interfaces and the integration of these services into networks. Additionally, a time schedule for the overall construction process has been specified. As a result this process advances with a strong participation of member states and responsible organisations. Today, SDIs provide the operational basis for new digital business processes in both national and local authorities. Currently, the development of integrated RIs in Earth and Environmental Sciences is characterised by the following properties: • A high number of parallel activities on European and national levels with numerous institutes and organisations participating

Funding | IDRC - International Development Research Centre

International Development Research Centre (IDRC) Digital Library (Canada)

2018-09-30

IDRC funds projects that aim to bring employment, food security, health, peace, and prosperity to developing regions of the world. We offer grants, funding, and awards to researchers and institutions to find ... Call for: Applications ... citizen of a developing country with a work permit in Canada valid until September 30, 2018;.

USU Alternative and Unconventional Energy Research and Development

Energy Technology Data Exchange (ETDEWEB)

Behunin, Robert [Utah State Univ., Logan, UT (United States); Wood, Byard [Utah State Univ., Logan, UT (United States); Heaslip, Kevin [Utah State Univ., Logan, UT (United States); Zane, Regan [Utah State Univ., Logan, UT (United States); Lyman, Seth [Utah State Univ., Logan, UT (United States); Simmons, Randy [Utah State Univ., Logan, UT (United States); Christensen, David [Utah State Univ., Logan, UT (United States)

2014-01-29

The purpose and rationale of this project has been to develop enduring research capabilities at Utah State University (USU) and the Utah State University Research Foundation (USURF) in a number of energy efficient and renewable energy areas including primarily a) algae energy systems, b) solar lighting, c) intuitive buildings, d) electric transportation, 3) unconventional energy environmental monitoring and beneficial reuse technologies (water and CO₂), f) wind energy profiling, and g) land use impacts. The long-term goal of this initiative has been to create high-wage jobs in Utah and a platform for sustained faculty and student engagement in energy research. The program’s objective has been to provide a balanced portfolio of R&D conducted by faculty, students, and permanent staff. This objective has been met. While some of the project’s tasks met with more success than others, as with any research project of this scope, overall the research has contributed valuable technical insight and broader understanding in key energy related areas. The algae energy systems research resulted in a highly productive workforce development enterprise as it graduated a large number of well prepared students entering alternative energy development fields and scholarship. Moreover, research in this area has demonstrated both the technological and economic limitations and tremendous potential of algae feedstock-based energy and co-products. Research conducted in electric transportation, specifically in both stationary and dynamic wireless inductive coupling charging technologies, has resulted in impactful advances. The project initiated the annual Conference on Electric Roads and Vehicles (http://www.cervconference.org/), which is growing and attracts more than 100 industry experts and scholars. As a direct result of the research, the USU/USURF spin-out startup, WAVE (Wireless Advanced Vehicle Electrification), continues work in wirelessly charged bus transit systems

Cooperation in research and development

International Nuclear Information System (INIS)

Ramanna, R.

1977-01-01

In planning scientific programs for rapid and extensive peaceful applications of atomic energy in any developing country, it is not fully realized that one of the most important inputs is a strong research and development (R and D) base with a well-oriented training program. The paper discusses the various ways in which R and D is required to assist in both indigenous and turnkey projects. The R and D organization should be broad based; i.e., it should have physicists, chemists (particularly specialists in water chemistry), health physicists, and engineers (particularly metallurgists for materials development, study of corrosion problems, etc.). The role of electronic engineers is also very significant from the viewpoint of designing reactor control systems. Another important advantage of having an R and D program is its general technological fallout, which aids the entire industrial structure of the country. The concept of regional cooperation is very important, particularly for atomic energy programs in developing countries that have similar conditions and levels of technological skills. This cooperation can be bilateral or multilateral under the auspices of the International Atomic Energy Agency. Scientists from several countries have been trained in our Center, and we also had a very successful India-Philippines-Agency Project in which scientists from many countries in the region participated in cooperative research programs

ISS and Shuttle Payload Research Development and Processing

Science.gov (United States)

Calhoun, Kyle A.

2010-01-01

NASA's ISS and Spacecraft Processing Directorate (UB) is charged with the performance of payload development for research originating through NASA, ISS international partners, and the National Laboratory. The Payload Development sector of the Directorate takes biological research approved for on orbit experimentation from its infancy stage and finds a way to integrate and implement that research into a payload on either a Shuttle sortie or Space Station increment. From solicitation and selection, to definition, to verification, to integration and finally to operations and analysis, Payload Development is there every step of the way. My specific work as an intern this summer has consisted of investigating data received by separate flight and ground control Advanced Biological Research Systems (ABRS) units for Advanced Plant Experiments (APEX) and Cambium research. By correlation and analysis of this data and specific logbook information I have been working to explain changes in environmental conditions on both the flight and ground control unit. I have then, compiled all of that information into a form that can be presentable to the Principal Investigator (PI). This compilation allows that PI scientist to support their findings and add merit to their research. It also allows us, as the Payload Developers, to further inspect the ABRS unit and its performance

Publications | Page 21 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 201 - 210 of 6387 ... Through books, articles, research publications, and studies, we aim to widen the ... Development Research Centre (IDRC), the project uses evidence to enhance the ... Greening South America, one business at a time.

Publications | Page 62 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 611 - 620 of 6341 ... IDRC works with developing-country researchers and institutions to build ... America, and Australia and to determine knowledge gaps for future research. ... health and rights framework for population and health policy, ...

Development of catchment research, with particular attention to Plynlimon and its forerunner, the East African catchments

Science.gov (United States)

Blackie, J. R.; Robinson, M.

2007-01-01

Dr J.S.G. McCulloch was deeply involved in the establishment of research catchments in East Africa and subsequently in the UK to investigate the hydrological consequences of changes in land use. Comparison of these studies provides an insight into how influential his inputs and direction have been in the progressive development of the philosophy, the instrumentation and the analytical techniques now employed in catchment research. There were great contrasts in the environments: tropical highland (high radiation, intense rainfall) vs. temperate maritime (low radiation and frontal storms), contrasting soils and vegetation types, as well as the differing social and economic pressures in developing and developed nations. Nevertheless, the underlying scientific philosophy was common to both, although techniques had to be modified according to local conditions. As specialised instrumentation and analytical techniques were developed for the UK catchments many were also integrated into the East African studies. Many lessons were learned in the course of these studies and from the experiences of other studies around the world. Overall, a rigorous scientific approach was developed with widespread applicability. Beyond the basics of catchment selection and the quantification of the main components of the catchment water balance, this involved initiating parallel process studies to provide information on specific aspects of catchment behaviour. This information could then form the basis for models capable of extrapolation from the observed time series to other periods/hydrological events and, ultimately, the capability of predicting the consequences of changes in catchment land management to other areas in a range of climates.

48 CFR 35.009 - Subcontracting research and development effort.

Science.gov (United States)

2010-10-01

... ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.009 Subcontracting research and development effort. Since the selection of R&D contractors is substantially based on... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Subcontracting research...

48 CFR 927.408 - Cosponsored research and development activities.

Science.gov (United States)

2010-10-01

... Cosponsored research and development activities. Because of the Department of Energy's statutory duties to disseminate data first produced under its contracts for research, development, and demonstration, the... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Cosponsored research and...

10 CFR 1021.212 - Research, development, demonstration, and testing.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Research, development, demonstration, and testing. 1021... ACT IMPLEMENTING PROCEDURES DOE Decisionmaking § 1021.212 Research, development, demonstration, and testing. (a) This section applies to the adoption and application of programs that involve research...

78 FR 78506 - Research and Development; Public Meeting

Science.gov (United States)

2013-12-26

... Safety R&D Initiatives on Packaging Testing Paperless Hazard Communications Pilot Program Odorization of.... PHMSA-2013-0261; Notice No. 13-21] Research and Development; Public Meeting AGENCY: Pipeline and... the Research and Development Forum to be held January 17, 2014, in Washington, DC. During this meeting...

India | Page 120 | IDRC - International Development Research Centre

International Development Research Centre (IDRC) Digital Library (Canada)

A strong mining sector can provide "good" jobs and generate much needed revenue for cash-strapped governments. But it can also ruin landscapes and transform communities. In the Indian state of Goa, researchers supported by Canada's International Development Research Centre (IDRC) have developed a series of ...

When Research Meets Development: Antecedents and Implications of Transfer Speed

NARCIS (Netherlands)

Du, J.; Leten, B.; Vanhaverbeke, W.; Lopez-Vega, H.

2014-01-01

This paper focuses on the organization of new product development in large, R&D-intensive firms. In these firms, research and development activities are often separated. Research is conducted in dedicated research projects at specialized research labs. Once research results are achieved by research

Research and development for ethylbenzene production

Energy Technology Data Exchange (ETDEWEB)

Xue, Mingwei; Sun, Hongmin; Shen, Zhenhao; Zhang, Bin; Yang, Weimin [SINOPEC Shanghai Research Institute of Petrochemical Technology (China); Huan, Mingyao

2013-11-01

Ethylbenzene (EB) is important raw material for the production of styrene. Now, EB is mainly produced by the alkylation of benzene with ethylene catalyzed by zeolite in vapour phase or liquid phase. Shanghai Research Institute of Petrochemical Technology (SRIPT) began to research the catalysts for the production of ethylbenezene in 1993. With near 20 years work, three series of catalysts for the alkylation of benzene with pure ethylene, dilute ethylene and ethanol are in commerical in China. This paper mainly introduced the research and development of SRIPT for the EB production. (orig.)

Current status of research and development at Japan Atomic Energy Agency

International Nuclear Information System (INIS)

2015-01-01

This paper introduces the current state and future prospects of Japan Atomic Energy Agency, with a focus on the main achievements of the research and development as of November FY2014. The items of research and development are as follows; (1) research and development related to measures for the accident of Fukushima Daiichi Nuclear Power Station, (2) technological assistance for ensuring safety in the research and development and utilization of nuclear power, (3) research science related to the research and development and utilization of nuclear power, (4) practical application of FBR cycle, (5) technological development related to back-end measures, (6) research and development of technological system to retrieve nuclear fusion energy, and (7) common projects (computational science / engineering / research, technological development and policy assistance on nuclear non-proliferation and nuclear security, and various activities such as dissemination of the fruits of research and development, human resource development, and technological cooperation). (A.O.)

Nuclear boom - challenge for research and development

International Nuclear Information System (INIS)

Korec, M.; Liska, P.

2009-01-01

In this lecture authors present research and development in which VUJE, a. s. has participated. Authors concluded that resume as soon as possible the short-term research and development tasks for the existing SE reactors, both, operational reactors of SE and for shut-downed reactors - JAVYS. (Financing with the contribution from the state but major part from the industry). In cooperation with state institutions, regulatory authorities and investor (would-be operator) and supplier (suppliers) define and prepare tasks focused on issues of new-built Generation III reactors (Financing split between the state and industry in accordance with the characteristics of the tasks). Begin preparing tasks for resolving development problems of Generation IV reactors: - Persuade politicians abut the inevitability of state participation in the process, including financing; - Involve in the process institutions that can significantly contribute to the problems resolving (mainly on technical level, but also on organization and potentially financial level); - Prepare international cooperation agreements in this field (based on the existing agreements, preparation of new agreements); - Define technical areas of cooperation (research infrastructure, experimental and development facilities, simulation tools).

Research Thinking Development by Teaching Archaeoastronomy

Science.gov (United States)

Muglova, P. V.; Stoev, A. D.

2006-08-01

A model of research thinking development by teaching archaeoastronomy in specialized three-year extra-curriculum Astronomy programme and creation of favourable socio-educational surroundings is suggested. It is shown as a didactic system of conditions, influences and possibilities of answering specific hierarchic complex of personal needs in the 14 - 18 year age interval. Transformation of these needs in worldly values secures an active position of the students in the educational process and determines their personality development. It is also shown that the Archaeoastronomy School, as an educational environment, executes specific work of students' teaching, upbringing and progress as well as their inclusion in the real process of scientific research. Thus, they have the possibility of generating scientific ideas and obtaining results in the science archaeoastronomy. In consequence of this, their activity acquires social significance. Usages of this model of scientific school in the extra-curriculum Astronomy education reproduces norms and traditions of the real scientific research and directly relay subject content, cultural norms and values of archaeoastronomy in the educative process. Students' participation in archaeoastronomical expeditions, their competent work during the research of concrete archaeoastronomical objects create an investigation style of thinking and steady habits of scientific activity.

Sewage epidemiology and illicit drug research: the development of ethical research guidelines.

Science.gov (United States)

Prichard, Jeremy; Hall, Wayne; de Voogt, Pim; Zuccato, Ettore

2014-02-15

To discuss the need to develop ethical guidelines for researchers using sewage epidemiology to monitor drug use in the general population and specific precincts, including prisons, schools and workplaces. Describe current applications of sewage epidemiology, identify potential ethical risks associated with this science, and identify key means by which these risks may be mitigated through proportionate ethical guidance that allows this science to be fully developed. A rapidly advancing field of research is sewage epidemiology (SE) - the analysis of wastewater samples to monitor illicit drug use and other substances. Typically this research involves low ethical risks because individual participants cannot be identified and, consequently, review has been waived by human research ethics committees. In the absence of such oversight, ethical research guidelines are recommended for SE teams, peer reviewers and journal editors; guidelines will assist them to mitigate any risks in general population studies and studies of prisons, schools and workplaces. Potential harms include the stigmatisation of participants and, in the prison setting, austere policy responses to SE data that impact negatively upon inmate-participants. The risk of harm can be managed through research planning, awareness of the socio-political context in which results will be interpreted (or, in the case of media, sensationalised) and careful relations with industry partners. Ethical guidelines should be developed in consultation with SE scholars and be periodically amended. They should include publication processes that safeguard scientific rigour and be promulgated through existing research governance structures. Guidelines will assist to promote an ethical research culture among SE teams and scholars involved in the publication process and this will work to protect the reputation of the field. Copyright © 2014 Elsevier B.V. All rights reserved.