General Mechanical Repair. Minor Automotive Maintenance, Small Engine [Repair, and] Welding: Competency Test Package.

Science.gov (United States)

Hamlin, Larry

This document contains the competency test package for three sections of a general mechanical repair course: minor automotive maintenance, small engine mechanics, and welding. Following a list of the common essential elements for trade and industrial education, competency tests for the three sections are provided. Each test includes unit name,…

Biomedical engineering strategies for peripheral nerve repair: surgical applications, state of the art, and future challenges.

Science.gov (United States)

Pfister, Bryan J; Gordon, Tessa; Loverde, Joseph R; Kochar, Arshneel S; Mackinnon, Susan E; Cullen, D Kacy

2011-01-01

Damage to the peripheral nervous system is surprisingly common and occurs primarily from trauma or a complication of surgery. Although recovery of nerve function occurs in many mild injuries, outcomes are often unsatisfactory following severe trauma. Nerve repair and regeneration presents unique clinical challenges and opportunities, and substantial contributions can be made through the informed application of biomedical engineering strategies. This article reviews the clinical presentations and classification of nerve injuries, in addition to the state of the art for surgical decision-making and repair strategies. This discussion presents specific challenges that must be addressed to realistically improve the treatment of nerve injuries and promote widespread recovery. In particular, nerve defects a few centimeters in length use a sensory nerve autograft as the standard technique; however, this approach is limited by the availability of donor nerve and comorbidity associated with additional surgery. Moreover, we currently have an inadequate ability to noninvasively assess the degree of nerve injury and to track axonal regeneration. As a result, wait-and-see surgical decisions can lead to undesirable and less successful "delayed" repair procedures. In this fight for time, degeneration of the distal nerve support structure and target progresses, ultimately blunting complete functional recovery. Thus, the most pressing challenges in peripheral nerve repair include the development of tissue-engineered nerve grafts that match or exceed the performance of autografts, the ability to noninvasively assess nerve damage and track axonal regeneration, and approaches to maintain the efficacy of the distal pathway and targets during the regenerative process. Biomedical engineering strategies can address these issues to substantially contribute at both the basic and applied levels, improving surgical management and functional recovery following severe peripheral nerve injury.

Development of management system for plant repairing work

International Nuclear Information System (INIS)

Terauchi, Makoto

1999-01-01

In the fast breeder reactor, ''Monju'', in order to conduct nuclear plant repairing works securely and effectively, development of a computer system to assist management business on plant repairing work was begun on 1993. The system has been applied to about 5,000 times of operational management through past four times of plant inspection and to daily inspections and maintenance, and is daily used at working places of ''Monju'' such as issue/management of about 110,000 times of operational prohibition tag in isolated management. And, by automation of issue/management on working sheets and operational prohibition tag and others conducted hitherto by hand, the management business has been largely rationalized. (G.K.)

Cost-effectiveness of endovascular repair, open repair, and conservative management of splenic artery aneurysms

NARCIS (Netherlands)

Hogendoorn, Wouter; Lavida, Anthi; Hunink, M. G Myriam; Moll, Frans L.; Geroulakos, George; Muhs, Bart E.; Sumpio, Bauer E.

2015-01-01

Objective Open repair (OPEN) and conservative management (CONS) have been the treatments of choice for splenic artery aneurysms (SAAs) for many years. Endovascular repair (EV) has been increasingly used with good short-term results. In this study, we evaluated the cost-effectiveness of OPEN, EV, and

Surgical management of colorectal injuries: colostomy or primary repair?

Science.gov (United States)

Papadopoulos, V N; Michalopoulos, A; Apostolidis, S; Paramythiotis, D; Ioannidis, A; Mekras, A; Panidis, S; Stavrou, G; Basdanis, G

2011-10-01

Several factors have been considered important for the decision between diversion and primary repair in the surgical management of colorectal injuries. The aim of this study is to clarify whether patients with colorectal injuries need diversion or not. From 2008 to 2010, ten patients with colorectal injuries were surgically treated by primary repair or by a staged repair. The patients were five men and five women, with median age 40 years (20-55). Two men and two women had rectal injuries, while 6 patients had colon injuries. The mechanism of trauma in two patients was firearm injuries, in two patients was a stab injury, in four patients was a motor vehicle accident, in one woman was iatrogenic injury during vaginal delivery, and one case was the transanal foreign body insertion. Primary repair was possible in six patients, while diversion was necessary in four patients. Primary repair should be attempted in the initial surgical management of all penetrating colon and intraperitoneal rectal injuries. Diversion of colonic injuries should only be considered if the colon tissue itself is inappropriate for repair due to severe edema or ischemia. The role of diversion in the management of unrepaired extraperitoneal rectal injuries and in cases with anal sphincter injuries is mandatory.

Multiple Learning Strategies Project. Small Engine Repair Service. Regular Vocational. [Vol. 1.

Science.gov (United States)

Pitts, Jim; And Others

This instructional package is one of two designed for use by regular vocational students in the vocational area of small engine repair service. Contained in this document are forty-four learning modules organized into ten units: engine block; air cleaner; starters; fuel tanks; lines, filters, and pumps; carburetors; electrical; magneto systems;…

Small Engine Repair Modules (Workbook) = Reparacion de Motores Pequenos (Guia de Trabajo)

Science.gov (United States)

New York State Dept. of Correctional Services, Albany.

This package contains an English-Language set of task procedure sheets dealing with small-engine repair and a Spanish translation of the same material. Addressed in the individual sections of the manual are the following aspects of engine tune-up, reconditioning, and troubleshooting: servicing air cleaners; cleaning gas tanks, fuel lines, and fuel…

AC maintenance and repair manual for diesel engines

CERN Document Server

Pallas, Jean-Luc

2013-01-01

The aim of this book with its detailed step-by-step colour photographs and diagrams, is to enable every owner to fix their diesel engine with ease. Troubleshooting tables help diagnose potential problems, and there is advice on regular maintenance and winterising and repair. Jean-Luc Pallas's enthusiasm for passing on his knowledge, as well as his clear explanations, precise advice and step-by-step instructions make this a unique book.

Laser Engineered Net Shape (LENS) Technology for the Repair of Ni-Base Superalloy Turbine Components

Science.gov (United States)

Liu, Dejian; Lippold, John C.; Li, Jia; Rohklin, Stan R.; Vollbrecht, Justin; Grylls, Richard

2014-09-01

The capability of the laser engineered net shape (LENS) process was evaluated for the repair of casting defects and improperly machined holes in gas turbine engine components. Various repair geometries, including indentations, grooves, and through-holes, were used to simulate the actual repair of casting defects and holes in two materials: Alloy 718 and Waspaloy. The influence of LENS parameters, including laser energy density, laser scanning speed, and deposition pattern, on the repair of these defects and holes was studied. Laser surface remelting of the substrate prior to repair was used to remove machining defects and prevent heat-affected zone (HAZ) liquation cracking. Ultrasonic nondestructive evaluation techniques were used as a possible approach for detecting lack-of-fusion in repairs. Overall, Alloy 718 exhibited excellent repair weldability, with essentially no defects except for some minor porosity in repairs representative of deep through-holes and simulated large area casting defects. In contrast, cracking was initially observed during simulated repair of Waspaloy. Both solidification cracking and HAZ liquation cracking were observed in the repairs, especially under conditions of high heat input (high laser power and/or low scanning speed). For Waspaloy, the degree of cracking was significantly reduced and, in most cases, completely eliminated by the combination of low laser energy density and relatively high laser scanning speeds. It was found that through-hole repairs of Waspaloy made using a fine powder size exhibited excellent repair weldability and were crack-free relative to repairs using coarser powder. Simulated deep (7.4 mm) blind-hole repairs, representative of an actual Waspaloy combustor case, were successfully produced by the combination use of fine powder and relatively high laser scanning speeds.

CARTILAGE CONSTRUCTS ENGINEERED FROM CHONDROCYTES OVEREXPRESSING IGF-I IMPROVE THE REPAIR OF OSTEOCHONDRAL DEFECTS IN A RABBIT MODEL

Science.gov (United States)

Madry, Henning; Kaul, Gunter; Zurakowski, David; Vunjak-Novakovic, Gordana; Cucchiarini, Magali

2015-01-01

Tissue engineering combined with gene therapy is a promising approach for promoting articular cartilage repair. Here, we tested the hypothesis that engineered cartilage with chondrocytes over expressing a human insulin-like growth factor I (IGF-I) gene can enhance the repair of osteochondral defects, in a manner dependent on the duration of cultivation. Genetically modified chondrocytes were cultured on biodegradable polyglycolic acid scaffolds in dynamic flow rotating bioreactors for either 10 or 28 d. The resulting cartilaginous constructs were implanted into osteochondral defects in rabbit knee joints. After 28 weeks of in vivo implantation, immunoreactivity to ß-gal was detectable in the repair tissue of defects that received lacZ constructs. Engineered cartilaginous constructs based on IGF-I-over expressing chondrocytes markedly improved osteochondral repair compared with control (lacZ) constructs. Moreover, IGF-I constructs cultivated for 28 d in vitro significantly promoted osteochondral repair vis-à-vis similar constructs cultivated for 10 d, leading to significantly decreased osteoarthritic changes in the cartilage adjacent to the defects. Hence, the combination of spatially defined overexpression of human IGF-I within a tissue-engineered construct and prolonged bioreactor cultivation resulted in most enhanced articular cartilage repair and reduction of osteoarthritic changes in the cartilage adjacent to the defect. Such genetically enhanced tissue engineering provides a versatile tool to evaluate potential therapeutic genes in vivo and to improve our comprehension of the development of the repair tissue within articular cartilage defects. Insights gained with additional exploration using this model may lead to more effective treatment options for acute cartilage defects. PMID:23588785

Cartilage constructs engineered from chondrocytes overexpressing IGF-I improve the repair of osteochondral defects in a rabbit model

Directory of Open Access Journals (Sweden)

H Madry

2013-04-01

Full Text Available Tissue engineering combined with gene therapy is a promising approach for promoting articular cartilage repair. Here, we tested the hypothesis that engineered cartilage with chondrocytes overexpressing a human insulin-like growth factor I (IGF-I gene can enhance the repair of osteochondral defects, in a manner dependent on the duration of cultivation. Genetically modified chondrocytes were cultured on biodegradable polyglycolic acid scaffolds in dynamic flow rotating bioreactors for either 10 or 28 d. The resulting cartilaginous constructs were implanted into osteochondral defects in rabbit knee joints. After 28 weeks of in vivo implantation, immunoreactivity to ß-gal was detectable in the repair tissue of defects that received lacZ constructs. Engineered cartilaginous constructs based on IGF-I-overexpressing chondrocytes markedly improved osteochondral repair compared with control (lacZ constructs. Moreover, IGF-I constructs cultivated for 28 d in vitro significantly promoted osteochondral repair vis-à-vis similar constructs cultivated for 10 d, leading to significantly decreased osteoarthritic changes in the cartilage adjacent to the defects. Hence, the combination of spatially defined overexpression of human IGF-I within a tissue-engineered construct and prolonged bioreactor cultivation resulted in most enhanced articular cartilage repair and reduction of osteoarthritic changes in the cartilage adjacent to the defect. Such genetically enhanced tissue engineering provides a versatile tool to evaluate potential therapeutic genes in vivo and to improve our comprehension of the development of the repair tissue within articular cartilage defects. Insights gained with additional exploration using this model may lead to more effective treatment options for acute cartilage defects.

Nerve autografts and tissue-engineered materials for the repair of peripheral nerve injuries: a 5-year bibliometric analysis

Directory of Open Access Journals (Sweden)

Yuan Gao

2015-01-01

Full Text Available With advances in biomedical methods, tissue-engineered materials have developed rapidly as an alternative to nerve autografts for the repair of peripheral nerve injuries. However, the materials selected for use in the repair of peripheral nerve injuries, in particular multiple injuries and large-gap defects, must be chosen carefully. Various methods and materials for protecting the healthy tissue and repairing peripheral nerve injuries have been described, and each method or material has advantages and disadvantages. Recently, a large amount of research has been focused on tissue-engineered materials for the repair of peripheral nerve injuries. Using the keywords "pe-ripheral nerve injury", "autotransplant", "nerve graft", and "biomaterial", we retrieved publications using tissue-engineered materials for the repair of peripheral nerve injuries appearing in the Web of Science from 2010 to 2014. The country with the most total publications was the USA. The institutions that were the most productive in this field include Hannover Medical School (Germany, Washington University (USA, and Nantong University (China. The total number of publications using tissue-engineered materials for the repair of peripheral nerve injuries grad-ually increased over time, as did the number of Chinese publications, suggesting that China has made many scientific contributions to this field of research.

Shuttle Repair Tools Automate Vehicle Maintenance

Science.gov (United States)

2013-01-01

Successfully building, flying, and maintaining the space shuttles was an immensely complex job that required a high level of detailed, precise engineering. After each shuttle landed, it entered a maintenance, repair, and overhaul (MRO) phase. Each system was thoroughly checked and tested, and worn or damaged parts replaced, before the shuttle was rolled out for its next mission. During the MRO period, workers needed to record exactly what needed replacing and why, as well as follow precise guidelines and procedures in making their repairs. That meant traceability, and with it lots of paperwork. In 2007, the number of reports generated during electrical system repairs was getting out of hand-placing among the top three systems in terms of paperwork volume. Repair specialists at Kennedy Space Center were unhappy spending so much time at a desk and so little time actually working on the shuttle. "Engineers weren't spending their time doing technical work," says Joseph Schuh, an electrical engineer at Kennedy. "Instead, they were busy with repetitive, time-consuming processes that, while important in their own right, provided a low return on time invested." The strain of such inefficiency was bad enough that slow electrical repairs jeopardized rollout on several occasions. Knowing there had to be a way to streamline operations, Kennedy asked Martin Belson, a project manager with 30 years experience as an aerospace contractor, to co-lead a team in developing software that would reduce the effort required to document shuttle repairs. The result was System Maintenance Automated Repair Tasks (SMART) software. SMART is a tool for aggregating and applying information on every aspect of repairs, from procedures and instructions to a vehicle s troubleshooting history. Drawing on that data, SMART largely automates the processes of generating repair instructions and post-repair paperwork. In the case of the space shuttle, this meant that SMART had 30 years worth of operations

67. The safety engineering at driving of destroyed hearth and repair of bath fettling during operation

International Nuclear Information System (INIS)

Ivanov, A.V.

1993-01-01

The safety engineering at driving of destroyed hearth and repair of bath fettling during operation was considered. All operational conditions at driving of destroyed hearth and repair of bath fettling during operation were studied.

Evaluation of histological scoring systems for tissue-engineered, repaired and osteoarthritic cartilage

NARCIS (Netherlands)

Rutgers, M.; van Pelt, M.J.; Dhert, W.J.A.; Creemers, L.B.; Saris, D.B.F.

2010-01-01

Osteoarthritis and Cartilage Volume 18, Issue 1, January 2010, Pages 12-23 -------------------------------------------------------------------------------- Review Evaluation of histological scoring systems for tissue-engineered, repaired and osteoarthritic cartilage M. Rutgers†, M.J.P. van Pelt†,

Health care engineering management.

Science.gov (United States)

Jarzembski, W B

1980-01-01

Today, health care engineering management is merely a concept of dreamers, with most engineering decisions in health care being made by nonengineers. It is the purpose of this paper to present a rationale for an integrated hospital engineering group, and to acquaint the clinical engineer with some of the salient features of management concepts. Included are general management concepts, organization, personnel management, and hospital engineering systems.

Healthcare Technology Management (HTM) of mechanical ventilators by clinical engineers.

Science.gov (United States)

Yoshioka, Jun; Nakane, Masaki; Kawamae, Kaneyuki

2014-01-01

Mechanical ventilator failures expose patients to unacceptable risks, and maintaining mechanical ventilator safety is an important issue. We examined the usefulness of maintaining mechanical ventilators by clinical engineers (CEs) using a specialized calibrator. These evaluations and the ability to make in-house repairs proved useful for obviating the need to rent ventilators which, in turn, might prove faulty themselves. The CEs' involvement in maintaining mechanical ventilators is desirable, ensures prompt service, and, most importantly, enhances safe management of mechanical ventilators.

Genome engineering with TALENs and ZFNs: repair pathways and donor design.

Science.gov (United States)

Carroll, Dana; Beumer, Kelly J

2014-09-01

Genome engineering with targetable nucleases depends on cellular pathways of DNA repair after target cleavage. Knowledge of how those pathways work, their requirements and their active factors, can guide experimental design and improve outcomes. While many aspects of both homologous recombination (HR) and nonhomologous end joining (NHEJ) are shared by a broad range of cells and organisms, some features are specific to individual situations. This article reviews the influence of repair mechanisms on the results of gene targeting experiments, with an emphasis on lessons learned from experiments with Drosophila. Copyright © 2014 Elsevier Inc. All rights reserved.

Alternatives Analysis Amchitka Island Mud Pit Cap Repair, Amchitka, Alaska January 2016

Energy Technology Data Exchange (ETDEWEB)

Darr, Paul S. [US Department of Energy, Washington, DC (United States). Office of Legacy Management

2016-01-01

The U.S. Department of Energy (DOE) Office of Legacy Management (LM) manages the Nevada Offsites program, which includes a series of reclaimed drilling mud impoundments on Amchitka Island, Alaska (Figure 1). Navarro Research and Engineering, Inc. is the Legacy Management Support contractor (the Contractor) for LM. The Contractor has procured Tetra Tech, Inc. to provide engineering support to the Amchitka mud pit reclamation project. The mud pit caps were damaged during a 7.9-magnitude earthquake that occurred in 2014. The goals of the current project are to investigate conditions at the mud pit impoundments, identify feasible alternatives for repair of the cover systems and the contents, and estimate relative costs of repair alternatives. This report presents descriptions of the sites and past investigations, existing conditions, summaries of various repair/mitigation alternatives, and direct, unburdened, order-of-magnitude (-15% to +50%) associated costs.

Management of chronic pain after hernia repair

Directory of Open Access Journals (Sweden)

Andresen K

2018-04-01

Full Text Available Kristoffer Andresen, Jacob Rosenberg Department of Surgery, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark Abstract: Chronic pain following inguinal hernia repair is a common problem and feared complication. Up to 16% of people experience chronic pain following the repair of a groin hernia. The aim of this review was to provide an overview of treatment strategies for patients with chronic pain following inguinal hernia repair based on best practice guidelines and current clinical routines. The optimal management of chronic pain following inguinal hernia surgery should begin with a thorough clinical examination to rule out other causes of chronic pain and to rule out a recurrence. A scaled approach to treatment is recommended. Initially, watchful waiting can be tried if it can be tolerated by the patient and then systemic painkillers, escalating to blocks, and surgery as the final option. Surgery should include mesh removal and triple neurectomy following anterior approaches or mesh and tack removal following a posterior approach. The diagnosis and treatment strategies should be performed by or discussed with experts in the field. Keywords: inguinal hernia, chronic pain, management, surgery, pharmacology, radio frequency

Systems Engineering Management Plan

International Nuclear Information System (INIS)

1994-01-01

The purpose of this Monitored Retrievable Storage (MRS) Project Systems Engineering Management Plan (SEMP) is to define and establish the MRS Project Systems Engineering process that implements the approved policy and requirements of the Office of Civilian Radioactive Waste Management (OCRWM) for the US Department of Energy (DOE). This plan is Volume 5 of the MRS Project Management Plan (PMP). This plan provides the framework for implementation of systems engineering on the MRS Project consistent with DOE Order 4700.1, the OCRWM Program Management System Manual (PMSM), and the OCRWM Systems Engineering Management Plan (SEMP)

Management of radiological related equipments. Creating the equipment management database and analysis of the repair and maintenance records

International Nuclear Information System (INIS)

Eguchi, Megumu; Taguchi, Keiichi; Oota, Takashi; Kajiwara, Hiroki; Ono, Kiyotune; Hagio, Kiyofumi; Uesugi, Ekizo; Kajishima, Tetuo; Ueda, Kenji

2002-01-01

In 1997, we established the committee of equipments maintenance and management in our department. We designed the database in order to classify and register all the radiological related equipments using Microsoft Access. The management of conditions and cost of each equipment has become easier, by keeping and recording the database in the equipments management ledger and by filing the history of repairs or maintenances occurred to modalities. We then accounted numbers, cost of repairs and downtimes from the data of the repair and maintenance records for four years, and we reexamined the causal analysis of failures and the contents of the regular maintenance for CT and MRI equipments that had shown the higher numbers of repairs. Consequently, we have found the improvement of registration method of the data and the more economical way to use of the cost of repair. (author)

POLLUTION PREVENTION OPPORTUNITY ASSESSMENT UNITED STATES ARMY CORPS OF ENGINEERS PITTSBURGH ENGINEER WAREHOUSE AND REPAIR STATION AND EMSWORTH LOCKS AND DAMS PITTSBURGH, PENNSYLVANIA

Science.gov (United States)

This report summarizes work conducted at the United States Army Corps of Engineers (USACE) Pittsburgh Engineering Warehouse and Repair Station (PEWARS) and Emsworth Locks and Dams in Pittsburgh, Pennsylvania under the U.S. Environmental Protection Agency's (EPA's) Waste Reduction...

Imaging and management of complications of open surgical repair of abdominal aortic aneurysms

International Nuclear Information System (INIS)

Nayeemuddin, M.; Pherwani, A.D.; Asquith, J.R.

2012-01-01

Open repair is still considered the reference standard for long-term repair of abdominal aortic aneurysms (AAA). In contrast to endovascular aneurysm repair (EVAR), patients with open surgical repair of AAA are not routinely followed up with imaging. Although complications following EVAR are widely recognized and routinely identified on follow-up imaging, complications also do occur following open surgical repair. With frequent use of multi-slice computed tomography (CT) angiography (CTA) in vascular patients, there is now improved recognition of the potential complications following open surgical repair. Many of these complications are increasingly being managed using endovascular techniques. The aim of this review is to illustrate a variety of potential complications that may occur following open surgical repair and to demonstrate their management using both surgical and endovascular techniques.

Tissue engineering applications: cartilage lesions repair by the use of autologous chondrocytes

Directory of Open Access Journals (Sweden)

L. De Franceschi

2011-09-01

Full Text Available Promising new therapies based on tissue engineering have been recently developed for cartilage repair. The association of biomaterials with autologous chondrocytes expanded in vitro can represent a useful tool to regenerate this tissue. The scaffolds utilised in such therapeutical applications should provide a pre-formed three-dimensional shape, prevent cells from floating out of the defect, have sufficient mechanical strength, facilitate uniform spread of cells and stimulate the phenotype of transplanted cells. Hyaff®-11 is a hyaluronic-acid based biodegradable polymer, that has been shown to provide successful cell carrier for tissue-engineered repair. From our findings we can state that human chondrocytes seeded on Hyaff®-11 are able to maintain in vitro the characteristic of differentiated cells, expressing and producing collagen type II and aggrecan which are the main markers of cartilage phenotype, down-regulating collagen type I. Moreover, it seems to be a useful scaffold for cartilage repair both in animal models and clinical trials in humans, favouring the formation of a hyaline-like tissue. In the light of these data, we can hypothesise, for the future, the use of autologous chondrocyte transplantation together with gene therapy as a treatment for rheumatic diseases such as osteoarthritis.

Research and development strategy and maintenance engineering to strengthen the basis of ageing management

International Nuclear Information System (INIS)

Sekimura, Naoto

2006-01-01

The major research and development fields for ageing management of complex systems such as nuclear power plants are categorized into the following 4 items; 1) research and development of technologies for inspection, evaluation and repair in the components and materials, 2) engineering information systems, 3) development of codes and standards and 4) synthesized maintenance engineering. The 'synthesized maintenance engineering' field includes methodologies for optimum combination for inspection, maintenance actions and cost, definition of importance of components for maintenance, and performance indicates of a power plant system. Studying and learning these systematic approaches is also indicated in the Road Map as one of the important issues for collaboration of industries, regulatory bodies and universities to keep leading engineers and to improve regulatory systems. (author)

Site systems engineering: Systems engineering management plan

Energy Technology Data Exchange (ETDEWEB)

Grygiel, M.L. [Westinghouse Hanford Co., Richland, WA (United States)

1996-05-03

The Site Systems Engineering Management Plan (SEMP) is the Westinghouse Hanford Company (WHC) implementation document for the Hanford Site Systems Engineering Policy, (RLPD 430.1) and Systems Engineering Criteria Document and Implementing Directive, (RLID 430.1). These documents define the US Department of Energy (DOE), Richland Operations Office (RL) processes and products to be used at Hanford to implement the systems engineering process at the site level. This SEMP describes the products being provided by the site systems engineering activity in fiscal year (FY) 1996 and the associated schedule. It also includes the procedural approach being taken by the site level systems engineering activity in the development of these products and the intended uses for the products in the integrated planning process in response to the DOE policy and implementing directives. The scope of the systems engineering process is to define a set of activities and products to be used at the site level during FY 1996 or until the successful Project Hanford Management Contractor (PHMC) is onsite as a result of contract award from Request For Proposal DE-RP06-96RL13200. Following installation of the new contractor, a long-term set of systems engineering procedures and products will be defined for management of the Hanford Project. The extent to which each project applies the systems engineering process and the specific tools used are determined by the project`s management.

Project management for engineers

CERN Document Server

Bennett, Michael J

2014-01-01

Project Management for Engineers, as the title suggests, is a direct attempt at addressing the ever-increasing and specific needs for better project management of engineering students, practicing engineers and managers in the industry. It aims not only to present the principles and techniques of Project Management, but also to discuss project management standards, processes and requirements, such as PMBOK, IEEE and PRINCE. Each chapter begins with the basics of the theme being developed at a level understandable to an undergraduate, before more complex topics are introduced at the end of each section that are suitable for graduate students. For the practicing professionals or managers in the industry, the book also provides many real illustrations of practical application of the principles of Project Management. Through a realistic blend of theory and practical examples, as well as an integration of the engineering technical issues with business issues, this book seeks to remove the veil of mystery that has...

10th International Conference on Management Science and Engineering Management

CERN Document Server

Hajiyev, Asaf; Nickel, Stefan; Gen, Mitsuo

2017-01-01

This book presents the proceedings of the Tenth International Conference on Management Science and Engineering Management (ICMSEM2016) held from August 30 to September 02, 2016 at Baku, Azerbaijan and organized by the International Society of Management Science and Engineering Management, Sichuan University (Chengdu, China) and Ministry of Education of Azerbaijan. The aim of conference was to foster international research collaborations in management science and engineering management as well as to provide a forum to present current research findings. The presented papers were selected and reviewed by the Program Committee, made up of respected experts in the area of management science and engineering management from around the globe. The contributions focus on identifying management science problems in engineering, innovatively using management theory and methods to solve engineering problems effectively and establishing novel management theories and methods to address new engineering management issues.

9th International Conference on Management Science and Engineering Management

CERN Document Server

Nickel, Stefan; Machado, Virgilio; Hajiyev, Asaf

2015-01-01

This is the Proceedings of the Ninth International Conference on Management Science and Engineering Management (ICMSEM) held from July 21-23, 2015 at Karlsruhe, Germany. The goals of the conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current findings. These proceedings cover various areas in management science and engineering management. It focuses on the identification of management science problems in engineering and innovatively using management theory and methods to solve engineering problems effectively. It also establishes a new management theory and methods based on experience of new management issues in engineering. Readers interested in the fields of management science and engineering management will benefit from the latest cutting-edge innovations and research advances presented in these proceedings and will find new ideas and research directions. A total number of 132 papers from 15 countries a...

Engineering change management report 2011

DEFF Research Database (Denmark)

Maier, Anja; Langer, Stefan

Changes or modifications have always been a fundamental part of product- and service design, yet they are often costly and potentially decrease overall development efficiency and effectiveness. How Danish manufacturing firms are able to improve engineering change management practice is a decisive......, challenges, and strategies for improved engineering change management of more than 90 engineering firms from different industry sectors and sizes in Denmark. In particular, the report presents an overview of current practice of engineering change management in Denmark, shows the extent to which engineering...... implementation, with software use in comparison being surprisingly low. The biggest problems listed range from engineering change process support to internal and external communication and the need for company-internal awareness and competence training for better engineering change management. The biggest need...

Design of self-growing, self-sensing, and self-repairing materials for engineering applications

Science.gov (United States)

Dry, Carolyn M.

2001-04-01

Like natural biological building systems these materials are inexpensive, and self-form through interaction of the materials. They sense and self-repair, respond to changes in the environment. The volume and scale, cost and end use are all considered from the start. The purpose of the particular system we will describe is an engineered bridge. The materials form as bone does from the innate attributes of the material without much labor. They sense the environment, respond to it, and repair any damage. This composite bridge is designed from a self-forming polymer and concrete system. Internal release of chemicals, their properties and location account for responsiveness to change and for repair. The choice of matrix additives also allow for the responsiveness. Bridge frames were fabricated for dynamic testing. The results showed that self repair and response to loads could be accomplished by careful placement of chemicals for later release and by use of chemicals which could alter such attributes as stiffness, flexure and permanent deformation. Internal viewing sensors could determine the state of the frames after testing.

Repair/maintenance design for tokamak experimental fusion reactor

International Nuclear Information System (INIS)

1978-10-01

Repair and maintenance design for JXFR has been studied. The reactor is in eight modules so that a damaged module alone can be separated from the other modules and transferred from the reactor room to a repair shop. Design work covers overhaul procedure, dismounting equipments (overhead cranes, auto welder/cutter and remote handling equipments), transport system of a module (module mounting carriages and rotating carriage), repair equipment for blanket, earthquake-proof analysis of the reactor, reactor room structure, repair shop layout, management of radioactive wastes, time and the number of persons required for overhaul etc. Though the repair and maintenance system is almost complete, there still remain problems for further study in joints of blanket cooling piping, auto welder/cutter and earthquake-proof strength in reactor disassemblage. More detailed studies and R and D are necessary for engineering perfection. (author)

Document management in engineering construction

International Nuclear Information System (INIS)

Liao Bing

2008-01-01

Document management is one important part of systematic quality management, which is one of the key factors to ensure the construction quality. In the engineering construction, quality management and document management shall interwork all the time, to ensure the construction quality. Quality management ensures that the document is correctly generated and adopted, and thus the completeness, accuracy and systematicness of the document satisfy the filing requirements. Document management ensures that the document is correctly transferred during the construction, and various testimonies such as files and records are kept for the engineering construction and its quality management. This paper addresses the document management in the engineering construction based on the interwork of the quality management and document management. (author)

Systems Engineering and Management Applications of ISO 9001:2015 for Government

Science.gov (United States)

Shepherd, Christena C.

2016-01-01

. Identification of stakeholder expectations, identifying solutions, creating specific product or service designs, production of the product or service, delivery to the public, and the associated management, planning, and control processes, are a familiar place to begin thinking of the overall system of identifying, designing, and competing a project or mission. Lining up this lifecycle with the ISO requirements (see Figure 1) illustrates how a quality management system is concerned with the same processes, and provides a governance and assurance function. If implemented properly, there are cost savings resulting from less rework, repair, reprocessing, failures, misplaced documents, and similar types of deficiencies1. Starting with an organization's systems engineering processes allows the organization to use their own terminology for a QMS plan, and tailor the plan to their own project or organization, so that it is more easily developed, understood, and implemented.

Present status of laser technology for maintenance and repair

International Nuclear Information System (INIS)

Sano, Yuji

2001-01-01

A laser has superior spatial and timely controllability and has no repulsive force at its use, it is a tool suitable for remote operation. And, as a partial processing with low exotherm and deformation by its use becomes possible, it can have an advantage omissible for post processes such as heat treatment and so on. Therefore, on in-situ repair of present constructions, laser is thought to be an optimum tool. And, in nuclear energy plants, maintenance and management of their instruments are important, and then a number of technical developments activating its advantages have been carried out. Above all, repair engineering around a reactor has a number of places difficult to access them for its operators, so remote engineering using laser is desired for in special. Here was described on the present status of development and realization containing protect conservation and inspection repair technology using laser. (G.K.)

8th International Conference on Management Science and Engineering Management

CERN Document Server

Cruz-Machado, Virgílio; Lev, Benjamin; Nickel, Stefan

2014-01-01

This is the Proceedings of the Eighth International Conference on Management Science and Engineering Management (ICMSEM) held from July 25 to 27, 2014 at Universidade Nova de Lisboa, Lisbon, Portugal and organized by International Society of Management Science and Engineering Management (ISMSEM), Sichuan University (Chengdu, China) and Universidade Nova de Lisboa (Lisbon, Portugal). The goals of the conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current findings. A total number of 138 papers from 14 countries are selected for the proceedings by the conference scientific committee through rigorous referee review. The selected papers in the second volume are focused on Computing and Engineering Management covering areas of Computing Methodology, Project Management, Industrial Engineering and Information Technology.

Advances in management engineering

CERN Document Server

2017-01-01

This book deals with research in open challenges in Management Engineering in the 21st century, as well as selected opportunities and solutions to remedy them. Management Engineering is an emerging field that extends the analytical methods used in traditional Industrial Engineering and Industrial Organization to address the economic, behavioral and social dimensions of companies and their environments. Management Engineering extends its domain beyond the firm and the market to encompass the modeling and policy design of physical landscapes populated by social agents. The developments of the 21st century have made it necessary to adopt an integrative and global view of the different methodologies and tools that facilitate managers’ decision-making processes, ranging from the strategic to the operational level. This book equips readers with precisely these urgently needed resources.

Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair

Science.gov (United States)

Agarwal, Rachit; García, Andrés J.

2015-01-01

Bone tissue has a remarkable ability to regenerate and heal itself. However, large bone defects and complex fractures still present a significant challenge to the medical community. Current treatments center on metal implants for structural and mechanical support and auto- or allo-grafts to substitute long bone defects. Metal implants are associated with several complications such as implant loosening and infections. Bone grafts suffer from donor site morbidity, reduced bioactivity, and risk of pathogen transmission. Surgical implants can be modified to provide vital biological cues, growth factors and cells in order to improve osseointegration and repair of bone defects. Here we review strategies and technologies to engineer metal surfaces to promote osseointegration with the host tissue. We also discuss strategies for modifying implants for cell adhesion and bone growth via integrin signaling and growth factor and cytokine delivery for bone defect repair. PMID:25861724

Engineering Asset Management and Infrastructure Sustainability : Proceedings of the 5th World Congress on Engineering Asset Management

CERN Document Server

Ma, Lin; Tan, Andy; Weijnen, Margot; Lee, Jay

2012-01-01

Engineering Asset Management 2010 represents state-of-the art trends and developments in the emerging field of engineering asset management as presented at the Fifth World Congress on Engineering Asset Management (WCEAM). The proceedings of the WCEAM 2010 is an excellent reference for practitioners, researchers and students in the multidisciplinary field of asset management, covering topics such as: Asset condition monitoring and intelligent maintenance Asset data warehousing, data mining and fusion Asset performance and level-of-service models Design and life-cycle integrity of physical assets Education and training in asset management Engineering standards in asset management Fault diagnosis and prognostics Financial analysis methods for physical assets Human dimensions in integrated asset management Information quality management Information systems and knowledge management Intelligent sensors and devices Maintenance strategies in asset management Optimisation decisions in asset management Risk management ...

23rd International Conference on Industrial Engineering and Engineering Management 2016

CERN Document Server

Shen, Jiang; Dou, Runliang

2017-01-01

International Conference on Industrial Engineering and Engineering Management is sponsored by Chinese Industrial Engineering Institution, CMES, which is the unique national-level academic society of Industrial Engineering. The conference is held annually as the major event in this area. Being the largest and the most authoritative international academic conference held in China, it supplies an academic platform for the experts and the entrepreneurs in International Industrial Engineering and Management area to exchange their research results. Many experts in various fields from China and foreign countries gather together in the conference to review, exchange, summarize and promote their achievements in Industrial Engineering and Engineering Management fields. Some experts pay special attention to the current situation of the related techniques application in China as well as their future prospect, such as Industry 4.0, Green Product Design, Quality Control and Management, Supply Chain and logistics Management...

Engineering Education and Management - vol.2

CERN Document Server

Zhang, Chunliang; International Conference on Engineering Education and Management (ICEEM2011)

2012-01-01

This is the proceedings of the selected papers presented at 2011 International Conference on Engineering Education and Management (ICEEM2011) held in Guangzhou, China, during November 18-20, 2011. ICEEM2011 is one of the most important conferences in the field of Engineering Education and Management and is co-organized by Guangzhou University, The University of New South Wales, Zhejiang University and Xi’an Jiaotong University. The conference aims to provide a high-level international forum for scientists, engineers, and students to present their new advances and research results in the field of Engineering Education and Management. This volume comprises 122 papers selected from over 400 papers originally submitted by universities and industrial concerns all over the world. The papers specifically cover the topics of Management Science and Engineering, Engineering Education and Training, Project/Engineering Management, and Other related topics. All of the papers were peer-reviewed by selected experts. The p...

Multidisplinary Engineering, Project, and Production Management

OpenAIRE

Chien-Ho Ko

2012-01-01

Journal of Engineering, Project, and Production Management (EPPM-Journal) reflect the journal’s multidisciplinary approach to management research and can be categorized as belonging to three general topics: Project Management, Engineering and Project Management, and Project and Production Management.

7th International Conference on Management Science and Engineering Management

CERN Document Server

Fry, John; Lev, Benjamin; Hajiyev, Asaf; Vol.I Focused on Electrical and Information Technology; Vol.II Focused on Electrical and Information Technology

2014-01-01

This book presents the proceedings of the Seventh International Conference on Management Science and Engineering Management (ICMSEM2013) held from November 7 to 9, 2013 at Drexel University, Philadelphia, Pennsylvania, USA and organized by the International Society of Management Science and Engineering Management, Sichuan University (Chengdu, China) and Drexel University (Philadelphia, Pennsylvania, USA).   The goals of the Conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current research findings. The selected papers cover various areas in management science and engineering management, such as Decision Support Systems, Multi-Objective Decisions, Uncertain Decisions, Computational Mathematics, Information Systems, Logistics and Supply Chain Management, Relationship Management, Scheduling and Control, Data Warehousing and Data Mining, Electronic Commerce, Neural Networks, Stochastic Models and Simulation, F...

Essentials of Project and Systems Engineering Management

CERN Document Server

Eisner, Howard S

2008-01-01

The Third Edition of Essentials of Project and Systems Engineering Management enables readers to manage the design, development, and engineering of systems effectively and efficiently. The book both defines and describes the essentials of project and systems engineering management and, moreover, shows the critical relationship and interconnection between project management and systems engineering. The author's comprehensive presentation has proven successful in enabling both engineers and project managers to understand their roles, collaborate, and quickly grasp and apply all the basic princip

Multidisplinary Engineering, Project, and Production Management

Directory of Open Access Journals (Sweden)

Chien-Ho Ko

2012-01-01

Full Text Available Journal of Engineering, Project, and Production Management (EPPM-Journal reflect the journal’s multidisciplinary approach to management research and can be categorized as belonging to three general topics: Project Management, Engineering and Project Management, and Project and Production Management.

Using radionuclide imaging for monitoring repairment of bone defect with tissue-engineered bone graft in rabbits

International Nuclear Information System (INIS)

Xia Changsuo; Ye Fagang; Zou Yunwen; Ji Shixiang; Wang Dengchun

2004-01-01

Objective: To observe the effect of tissue-engineered bone grafts in repairing bone defect in rabbits, and assess the value of radionuclide for monitoring the therapeutic effect of this approach. Methods: Bilateral radial defects of 15 mm in length in 24 rabbits were made. The tissue-engineered bone grafts (composite graft) contained bone marrow stromal cells (BMSCs) of rabbits and calcium phosphate cement (CPC) were grafted in left side defects, CPC only grafts (artificial bone graft) in right defects. After the operation, radionuclide was used to monitor the therapeutic effects at 4, 8 and 12 weeks. Results: 99 Tc m -methylene diphosphonic acid (MDP) radionuclide bone imaging indicated that there was more radionuclide accumulation in grafting region of composite than that of CPC. There was significant difference between 99 Tc m -MDP uptake of the region of interest (ROI) and scintillant counts of composite bone and the artificial bone (P<0.01). Conclusion: Tissue-engineered bone grafts is eligible for repairing radial bone defects, and radionuclide imaging may accurately monitor the revascularization and bone regeneration after the bone graft implantation. (authors)

Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations

Directory of Open Access Journals (Sweden)

Christopher M. Mahoney

2018-05-01

Full Text Available Tissue engineered scaffolds for adipose restoration/repair has significantly evolved in recent years. Patients requiring soft tissue reconstruction, caused by defects or pathology, require biomaterials that will restore void volume with new functional tissue. The gold standard of autologous fat grafting (AFG is not a reliable option. This review focuses on the latest therapeutic strategies for the treatment of adipose tissue defects using biomolecule formulations and delivery, and specifically engineered biomaterials. Additionally, the clinical need for reliable off-the-shelf therapies, animal models, and challenges facing current technologies are discussed.

Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations.

Science.gov (United States)

Mahoney, Christopher M; Imbarlina, Cayla; Yates, Cecelia C; Marra, Kacey G

2018-01-01

Tissue engineered scaffolds for adipose restoration/repair has significantly evolved in recent years. Patients requiring soft tissue reconstruction, caused by defects or pathology, require biomaterials that will restore void volume with new functional tissue. The gold standard of autologous fat grafting (AFG) is not a reliable option. This review focuses on the latest therapeutic strategies for the treatment of adipose tissue defects using biomolecule formulations and delivery, and specifically engineered biomaterials. Additionally, the clinical need for reliable off-the-shelf therapies, animal models, and challenges facing current technologies are discussed.

Engineering a multimodal nerve conduit for repair of injured peripheral nerve

Science.gov (United States)

Quigley, A. F.; Bulluss, K. J.; Kyratzis, I. L. B.; Gilmore, K.; Mysore, T.; Schirmer, K. S. U.; Kennedy, E. L.; O'Shea, M.; Truong, Y. B.; Edwards, S. L.; Peeters, G.; Herwig, P.; Razal, J. M.; Campbell, T. E.; Lowes, K. N.; Higgins, M. J.; Moulton, S. E.; Murphy, M. A.; Cook, M. J.; Clark, G. M.; Wallace, G. G.; Kapsa, R. M. I.

2013-02-01

hydrogel. This indicates return of some feeling to the limb via the fully-configured conduit. Immunohistochemical analysis of the implanted conduits removed from the rats after the four-week implantation period confirmed the presence of myelinated axons within the conduit and distal to the site of implantation, further supporting that the conduit promoted nerve repair over this period of time. This study describes the design considerations and fabrication of a novel multicomponent, multimodal bio-engineered synthetic conduit for peripheral nerve repair.

Site quality management of engineering projects

International Nuclear Information System (INIS)

Jiang Yiqun

2008-01-01

Site quality management of an engineering project of NPIC was introduced in this paper. Requirements on organization and management, interfaces, and management of interior and exterior communication were put forward, by description of quality planning, process management, process monitoring and summarizing for the engineering projects. By the management of personnel, specifications and procedures, and the control of equipment, material and work surroundings, not only the safety is ensured, but also the quality and schedule of the engineering project were guaranteed, and so the expected quality goals were achieved. (author)

46 CFR 35.25-5 - Repairs of boilers and unfired pressure vessels and reports of repairs or accidents by chief...

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Repairs of boilers and unfired pressure vessels and..., DEPARTMENT OF HOMELAND SECURITY TANK VESSELS OPERATIONS Engine Department § 35.25-5 Repairs of boilers and... any repairs to boilers or unfired pressure vessels, the chief engineer shall submit a report covering...

Repair of articular cartilage defects by tissue-engineered cartilage constructed with adipose-derived stem cells and acellular cartilaginous matrix in rabbits.

Science.gov (United States)

Wang, Z J; An, R Z; Zhao, J Y; Zhang, Q; Yang, J; Wang, J B; Wen, G Y; Yuan, X H; Qi, X W; Li, S J; Ye, X C

2014-06-18

After injury, inflammation, or degeneration, articular cartilage has limited self-repair ability. We aimed to explore the feasibility of repair of articular cartilage defects with tissue-engineered cartilage constructed by acellular cartilage matrices (ACMs) seeded with adipose-derived stem cells (ADSCs). The ADSCs were isolated from 3-month-old New Zealand albino rabbit by using collagenase and cultured and amplified in vitro. Fresh cartilage isolated from adult New Zealand albino rabbit were freeze-dried for 12 h and treated with Triton X-100, DNase, and RNase to obtain ACMs. ADSCs were seeded in the acellular cartilaginous matrix at 2x10(7)/mL, and cultured in chondrogenic differentiation medium for 2 weeks to construct tissue-engineered cartilage. Twenty-four New Zealand white rabbits were randomly divided into A, B, and C groups. Engineered cartilage was transplanted into cartilage defect position of rabbits in group A, group B obtained ACMs, and group C did not receive any transplants. The rabbits were sacrificed in week 12. The restored tissue was evaluated using macroscopy, histology, immunohistochemistry, and transmission electron microscopy (TEM). In the tissue-engineered cartilage group (group A), articular cartilage defects of the rabbits were filled with chondrocyte-like tissue with smooth surface. Immunohistochemistry showed type II-collagen expression and Alcian blue staining was positive. TEM showed chondrocytes in the recesses, with plenty of secretary matrix particles. In the scaffold group (group B), the defect was filled with fibrous tissue. No repaired tissue was found in the blank group (group C). Tissue-engineered cartilage using ACM seeded with ADSCs can help repair articular cartilage defects in rabbits.

Managing complexity challenges for industrial engineering and operations management

CERN Document Server

López-Paredes, Adolfo; Pérez-Ríos, José

2014-01-01

This book presents papers by experts in the field of Industrial Engineering, covering topics in business strategy; modelling and simulation in operations research; logistics and production; service systems; innovation and knowledge; and project management. The focus of operations and production management has evolved from product and manufacturing to the capabilities of firms and collaborative management. Nowadays, Industrial Engineering is concerned with the study of how to design, modify, control and improve the performance of complex systems. It has extended its scope to any physical landscape populated by social agents. This raises a major challenge to Industrial Engineering:  managing complexity. This volume shows how experts are dealing with this challenge.

Environmental Restoration Project - Systems Engineering Management Plan

International Nuclear Information System (INIS)

Anderson, T.D.

1998-06-01

This Environmental Restoration (ER) Project Systems Engineering Management Plan (SEMP) describes relevant Environmental Restoration Contractor (ERC) management processes and shows how they implement systems engineering. The objective of this SEMP is to explain and demonstrate how systems engineering is being approached and implemented in the ER Project. The application of systems engineering appropriate to the general nature and scope of the project is summarized in Section 2.0. The basic ER Project management approach is described in Section 3.0. The interrelation and integration of project practices and systems engineering are outlined in Section 4.0. Integration with sitewide systems engineering under the Project Hanford Management Contract is described in Section 5.0

Repair and managing device in nuclear power plants

International Nuclear Information System (INIS)

Shinzawa, Katsuo.

1982-01-01

Purpose: To moderate the operator's labour by automatically carrying out the managing works for the repair of nuclear power plants. Constitution: Information concerning the content of the repair works inputted from an input device is arranged and analyzed in a calculation device and judged if it is the content for a format work or not. The calculation device has a function of extracting the information regarding the format work content from the memory device and comparing the plant information from the reading device before the repair work and after the recovering work. A printer connected to the output end of the calculation device issues an information regarding the format work content extracted from the memory device, that is, written work procedures and operation inhibition TAG. The content, period, person in charge, purpose, allowed items and the likes for the works are printed on the operation inhibition TAG. After the operation for the equipments, one half of them is charged to the equipment and the other half of them is charged to the reading device and the plant information is sent to the memory device. (Kawakami, Y.)

Intelligent techniques in engineering management theory and applications

CERN Document Server

Onar, Sezi

2015-01-01

This book presents recently developed intelligent techniques with applications and theory in the area of engineering management. The involved applications of intelligent techniques such as neural networks, fuzzy sets, Tabu search, genetic algorithms, etc. will be useful for engineering managers, postgraduate students, researchers, and lecturers. The book has been written considering the contents of a classical engineering management book but intelligent techniques are used for handling the engineering management problem areas. This comprehensive characteristics of the book makes it an excellent reference for the solution of complex problems of engineering management. The authors of the chapters are well-known researchers with their previous works in the area of engineering management.

OCRWM Systems Engineering Management Plan (SEMP)

International Nuclear Information System (INIS)

1994-06-01

The Office of Civilian Radioactive Waste Management Systems Engineering Management Plan (OCRWM SEMP) specifies the technical management approach for the development of the waste management system, and specifies the approach for the development of each of the system elements -- the waste acceptance system, the transportation system, the Monitored Retrievable Storage (MRS) facility, and the mined geologic disposal system, which includes site characterization activity. The SEMP also delineates how systems engineering will be used by OCRWM to describe the system development process; it identifies responsibilities for its implementation, and specifies the minimum requirements for systems engineering. It also identifies the close interrelationship of system engineering and licensing processes. This SEMP, which is a combined OCRWM and M ampersand O SEMP, is part of the top-level program documentation and is prepared in accordance with the direction provided in the Program Management System Manual (PMSM). The relationship of this document to other top level documents in the CRWMS document hierarchy is defined in the PMSM. A systems engineering management plan for each project, which specifies the actions to be taken in implementing systems engineering at the project level, shall be prepared by the respective project managers. [''Program'' refers to the CRWMS-wide activity and ''project'' refers to that level responsible for accomplishing the specific activities of that segment of the program.] The requirements for the project level SEMPs are addressed in Section 4.2.2.2. They represent the minimum set of requirements, and do not preclude the broadening of systems engineering activities to meet the specific needs of each project

8th International Conference on Management Science and Engineering Management

CERN Document Server

Cruz-Machado, Virgílio; Lev, Benjamin; Nickel, Stefan

2014-01-01

This is the Proceedings of the Eighth International Conference on Management Science and Engineering Management (ICMSEM) held from July 25 to 27, 2014 at Universidade Nova de Lisboa, Lisbon, Portugal and organized by International Society of Management Science and Engineering Management (ISMSEM), Sichuan University (Chengdu, China) and Universidade Nova de Lisboa (Lisbon, Portugal). The goals of the conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current findings. A total number of 138 papers from 14 countries are selected for the proceedings by the conference scientific committee through rigorous referee review. The selected papers in the first volume are focused on Intelligent System and Management Science covering areas of Intelligent Systems, Decision Support Systems, Manufacturing and Supply Chain Management.

Defined Engineered Human Myocardium with Advanced Maturation for Applications in Heart Failure Modelling and Repair

Science.gov (United States)

Tiburcy, Malte; Hudson, James E.; Balfanz, Paul; Schlick, Susanne; Meyer, Tim; Liao, Mei-Ling Chang; Levent, Elif; Raad, Farah; Zeidler, Sebastian; Wingender, Edgar; Riegler, Johannes; Wang, Mouer; Gold, Joseph D.; Kehat, Izhak; Wettwer, Erich; Ravens, Ursula; Dierickx, Pieterjan; van Laake, Linda W.; Goumans, Marie Jose; Khadjeh, Sara; Toischer, Karl; Hasenfuss, Gerd; Couture, Larry A.; Unger, Andreas; Linke, Wolfgang A.; Araki, Toshiyuki; Neel, Benjamin; Keller, Gordon; Gepstein, Lior; Wu, Joseph C.; Zimmermann, Wolfram-Hubertus

2017-01-01

Background Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modelling, drug screening, and heart repair. Here, we sought to advance cardiomyocyte maturation in engineered human myocardium (EHM) towards an adult phenotype under defined conditions. Methods We systematically investigated cell composition, matrix and media conditions to generate EHM from embryonic and induced pluripotent stem cell-derived cardiomyocytes and fibroblasts with organotypic functionality under serum-free conditions. We employed morphological, functional, and transcriptome analyses to benchmark maturation of EHM. Results EHM demonstrated important structural and functional properties of postnatal myocardium, including: (1) rod-shaped cardiomyocytes with M-bands assembled as a functional syncytium; (2) systolic twitch forces at a similar level as observed in bona fide postnatal myocardium; (3) a positive force-frequency-response; (4) inotropic responses to β-adrenergic stimulation mediated via canonical β1- and β2-adrenoceptor signaling pathways; and (5) evidence for advanced molecular maturation by transcriptome profiling. EHM responded to chronic catecholamine toxicity with contractile dysfunction, cardiomyocyte hypertrophy, cardiomyocyte death, and NT-proBNP release; all are classical hallmarks of heart failure. Additionally, we demonstrate scalability of EHM according to anticipated clinical demands for cardiac repair. Conclusions We provide proof-of-concept for a universally applicable technology for the engineering of macro-scale human myocardium for disease modelling and heart repair from embryonic and induced pluripotent stem cell-derived cardiomyocytes under defined, serum-free conditions. PMID:28167635

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.

Science.gov (United States)

Tiburcy, Malte; Hudson, James E; Balfanz, Paul; Schlick, Susanne; Meyer, Tim; Chang Liao, Mei-Ling; Levent, Elif; Raad, Farah; Zeidler, Sebastian; Wingender, Edgar; Riegler, Johannes; Wang, Mouer; Gold, Joseph D; Kehat, Izhak; Wettwer, Erich; Ravens, Ursula; Dierickx, Pieterjan; van Laake, Linda W; Goumans, Marie Jose; Khadjeh, Sara; Toischer, Karl; Hasenfuss, Gerd; Couture, Larry A; Unger, Andreas; Linke, Wolfgang A; Araki, Toshiyuki; Neel, Benjamin; Keller, Gordon; Gepstein, Lior; Wu, Joseph C; Zimmermann, Wolfram-Hubertus

2017-05-09

Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modeling, drug screening, and heart repair. Here, we sought to advance cardiomyocyte maturation in engineered human myocardium (EHM) toward an adult phenotype under defined conditions. We systematically investigated cell composition, matrix, and media conditions to generate EHM from embryonic and induced pluripotent stem cell-derived cardiomyocytes and fibroblasts with organotypic functionality under serum-free conditions. We used morphological, functional, and transcriptome analyses to benchmark maturation of EHM. EHM demonstrated important structural and functional properties of postnatal myocardium, including: (1) rod-shaped cardiomyocytes with M bands assembled as a functional syncytium; (2) systolic twitch forces at a similar level as observed in bona fide postnatal myocardium; (3) a positive force-frequency response; (4) inotropic responses to β-adrenergic stimulation mediated via canonical β 1 - and β 2 -adrenoceptor signaling pathways; and (5) evidence for advanced molecular maturation by transcriptome profiling. EHM responded to chronic catecholamine toxicity with contractile dysfunction, cardiomyocyte hypertrophy, cardiomyocyte death, and N-terminal pro B-type natriuretic peptide release; all are classical hallmarks of heart failure. In addition, we demonstrate the scalability of EHM according to anticipated clinical demands for cardiac repair. We provide proof-of-concept for a universally applicable technology for the engineering of macroscale human myocardium for disease modeling and heart repair from embryonic and induced pluripotent stem cell-derived cardiomyocytes under defined, serum-free conditions. © 2017 American Heart Association, Inc.

Intersubjective management in aerospace engineering

Directory of Open Access Journals (Sweden)

Arpentieva Mariam

2017-01-01

Full Text Available This article presents a postnonclassical approach to create the science of management processes organization in a developing society, the focus of which is “the man of culture”, i.e. the man, not just adhering to cultural norms, but also creating new concepts and products of culture. This science is proposed to be called Evergetics. The purpose of the study is the analysis science of management processes organization in a developing aerospace engineering and other industrial areas of society. The authors describe the main aspects and procedures evergetics management in aerospace engineering. They uses the comparison method, compares classical and modern approaches and technologies of management. In evergetics management model each member of society or organization is interested in augmenting his cultural heritage he is producing, which entails a raise of stability in process of engineering actions and a raise cultural potential of the society as a whole and, as a consequence, an increase in the proportion of moral and ethical managerial decisions and corresponding to them benevolent actions in organizational life. Summarize the article’s main findings, authors may in some main conclusions about necessity evergetics model and intersubjective technologies in the creation and development of aerospace engineering.

Integrated water resources management using engineering measures

Science.gov (United States)

Huang, Y.

2015-04-01

The management process of Integrated Water Resources Management (IWRM) consists of aspects of policies/strategies, measures (engineering measures and non-engineering measures) and organizational management structures, etc., among which engineering measures such as reservoirs, dikes, canals, etc., play the backbone that enables IWRM through redistribution and reallocation of water in time and space. Engineering measures are usually adopted for different objectives of water utilization and water disaster prevention, such as flood control and drought relief. The paper discusses the planning and implementation of engineering measures in IWRM of the Changjiang River, China. Planning and implementation practices of engineering measures for flood control and water utilization, etc., are presented. Operation practices of the Three Gorges Reservoir, particularly the development and application of regulation rules for flood management, power generation, water supply, ecosystem needs and sediment issues (e.g. erosion and siltation), are also presented. The experience obtained in the implementation of engineering measures in Changjiang River show that engineering measures are vital for IWRM. However, efforts should be made to deal with changes of the river system affected by the operation of engineering measures, in addition to escalatory development of new demands associated with socio-economic development.

Integrated water resources management using engineering measures

Directory of Open Access Journals (Sweden)

Y. Huang

2015-04-01

Full Text Available The management process of Integrated Water Resources Management (IWRM consists of aspects of policies/strategies, measures (engineering measures and non-engineering measures and organizational management structures, etc., among which engineering measures such as reservoirs, dikes, canals, etc., play the backbone that enables IWRM through redistribution and reallocation of water in time and space. Engineering measures are usually adopted for different objectives of water utilization and water disaster prevention, such as flood control and drought relief. The paper discusses the planning and implementation of engineering measures in IWRM of the Changjiang River, China. Planning and implementation practices of engineering measures for flood control and water utilization, etc., are presented. Operation practices of the Three Gorges Reservoir, particularly the development and application of regulation rules for flood management, power generation, water supply, ecosystem needs and sediment issues (e.g. erosion and siltation, are also presented. The experience obtained in the implementation of engineering measures in Changjiang River show that engineering measures are vital for IWRM. However, efforts should be made to deal with changes of the river system affected by the operation of engineering measures, in addition to escalatory development of new demands associated with socio-economic development.

A systems engineering management approach to resource management applications

Science.gov (United States)

Hornstein, Rhoda Shaller

1989-01-01

The author presents a program management response to the following question: How can the traditional practice of systems engineering management, including requirements specification, be adapted, enhanced, or modified to build future planning and scheduling systems for effective operations? The systems engineering management process, as traditionally practiced, is examined. Extensible resource management systems are discussed. It is concluded that extensible systems are a partial solution to problems presented by requirements that are incomplete, partially immeasurable, and often dynamic. There are positive indications that resource management systems have been characterized and modeled sufficiently to allow their implementation as extensible systems.

2014 World Congress on Engineering Asset Management

CERN Document Server

Hoohlo, Changela; Mathew, Joe

2015-01-01

Engineering asset management encompasses all types of engineered assets including built environment, infrastructure, plant, equipment, hardware systems and components. Following the release of ISO 5500x set of standards, the 9th WCEAM addresses the hugely important issue of what constitutes the body of knowledge in Engineering Asset Management. Topics discussed by Congress delegates are grouped into a number of tracks including strategies for investment and divestment of assets, operations and maintenance of assets, assessments of assets condition, risk and vulnerability, technologies and systems for management of asset, standards, education, training and certification. These proceedings include a sample of the wide range of topics presented during the 9th World Congress on Engineering Asset Management in Pretoria South Africa 28 – 31 October, 2014 and complements other emerging publications and standards that embrace the wide ranging issues concerning the management of engineered physical assets.

Crack Growth-Based Predictive Methodology for the Maintenance of the Structural Integrity of Repaired and Nonrepaired Aging Engine Stationary Components

National Research Council Canada - National Science Library

Barron, Michael

1999-01-01

.... Specifically, the FAA's goal was to develop "Crack Growth-Based Predictive Methodologies for the Maintenance of the Structural Integrity of Repaired and Nonrepaired Aging Engine Stationary Components...

Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial.

Science.gov (United States)

Mumme, Marcus; Barbero, Andrea; Miot, Sylvie; Wixmerten, Anke; Feliciano, Sandra; Wolf, Francine; Asnaghi, Adelaide M; Baumhoer, Daniel; Bieri, Oliver; Kretzschmar, Martin; Pagenstert, Geert; Haug, Martin; Schaefer, Dirk J; Martin, Ivan; Jakob, Marcel

2016-10-22

Articular cartilage injuries have poor repair capacity, leading to progressive joint damage, and cannot be restored predictably by either conventional treatments or advanced therapies based on implantation of articular chondrocytes. Compared with articular chondrocytes, chondrocytes derived from the nasal septum have superior and more reproducible capacity to generate hyaline-like cartilage tissues, with the plasticity to adapt to a joint environment. We aimed to assess whether engineered autologous nasal chondrocyte-based cartilage grafts allow safe and functional restoration of knee cartilage defects. In a first-in-human trial, ten patients with symptomatic, post-traumatic, full-thickness cartilage lesions (2-6 cm 2 ) on the femoral condyle or trochlea were treated at University Hospital Basel in Switzerland. Chondrocytes isolated from a 6 mm nasal septum biopsy specimen were expanded and cultured onto collagen membranes to engineer cartilage grafts (30 × 40 × 2 mm). The engineered tissues were implanted into the femoral defects via mini-arthrotomy and assessed up to 24 months after surgery. Primary outcomes were feasibility and safety of the procedure. Secondary outcomes included self-assessed clinical scores and MRI-based estimation of morphological and compositional quality of the repair tissue. This study is registered with ClinicalTrials.gov, number NCT01605201. The study is ongoing, with an approved extension to 25 patients. For every patient, it was feasible to manufacture cartilaginous grafts with nasal chondrocytes embedded in an extracellular matrix rich in glycosaminoglycan and type II collagen. Engineered tissues were stable through handling with forceps and could be secured in the injured joints. No adverse reactions were recorded and self-assessed clinical scores for pain, knee function, and quality of life were improved significantly from before surgery to 24 months after surgery. Radiological assessments indicated variable degrees of

Role of strategic planning in engineering management

Science.gov (United States)

Krishen, Kumar

1993-01-01

Today, more than ever before, engineers are faced with uncertain and sometimes chaotic environments in which to function. The traditional roles of an engineer to design, develop, and streamline a manufacturing process for a product are still valued and relevant. However, the need for an engineer to participate in the process of identifying the product to be developed, the schedule and resources required, and the goal of satisfying the customer, has become paramount to achieving the success of the enterprise. When we include these endeavors in the functions of an engineer, management of 'engineering' takes on a new dimension. In this paper, the ramifications of the changing and increased functions of an engineer and consequent impacts on engineering management are explored. The basic principles which should be invoked in order to embrace the new environment for engineering management are outlined. The ultimate finding of this study is that the enterprise strategic plan should be developed in such a way as to allow engineering management to encompass the full spectrum of the responsibilities of engineers. A consequence of this is that the fundamental elements of the strategic process can best be implemented through a project team or group approach. The paper thus concentrates on three areas: evolving environment, strategic plan, and ways to achieve enterprise success.

Software And Systems Engineering Risk Management

Science.gov (United States)

2010-04-01

RSKM 2004 COSO Enterprise RSKM Framework 2006 ISO/IEC 16085 Risk Management Process 2008 ISO/IEC 12207 Software Lifecycle Processes 2009 ISO/IEC...1 Software And Systems Engineering Risk Management John Walz VP Technical and Conferences Activities, IEEE Computer Society Vice-Chair Planning...Software & Systems Engineering Standards Committee, IEEE Computer Society US TAG to ISO TMB Risk Management Working Group Systems and Software

Journal of Modeling, Design and Management of Engineering ...

African Journals Online (AJOL)

The Journal of Modeling, Design & Management of Engineering Systems publishes original ... systems Electronic/Electrical systems Engineering management systems Fuel and Energy systems Information Technology ... systems Pubic Health systems Software Engineering systems Systems and Industrial Engineering ...

Role of percutaneous mitral valve repair in the contemporary management of mitral regurgitation.

Science.gov (United States)

Rana, Bushra S; Calvert, Patrick A; Punjabi, Prakash P; Hildick-Smith, David

2015-10-01

Percutaneous mitral valve (MV) repair has been performed in over 20,000 patients worldwide. As clinical experience in this technique grows indications for its use are being defined. Mitral regurgitation (MR) encompasses a complex heterogeneous group and its treatment is governed by determining a clear understanding of the underlying aetiology. Surgical MV repair remains the gold standard therapy for severe MR. However in select groups of high-risk surgical patients, a percutaneous approach to MV repair is establishing its role. This review gives an overview of the published data in percutaneous MV repair and its impact on the contemporary management of MR. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Spent Nuclear Fuel project systems engineering management plan

International Nuclear Information System (INIS)

Womack, J.C.

1995-01-01

The purpose of the WHC Systems Engineering Management Plan (SEMP) is to describe the systems engineering approach and methods that will be integrated with established WHC engineering practices to enhance the WHC engineering management of the SNF Project. The scope of the SEMP encompasses the efforts needed to manage the WHC implementation of systems engineering on the SNF Project. This implementation applies to, and is tailored to the needs of the SNF project and all its subprojects, including all current and future subprojects

Snowmobile Repair. Teacher Edition.

Science.gov (United States)

Hennessy, Stephen S.; Conrad, Rex

This teacher's guide contains 14 units on snowmobile repair: (1) introduction to snowmobile repair; (2) skis, front suspension, and steering; (3) drive clutch; (4) drive belts; (5) driven clutch; (6) chain drives; (7) jackshafts and axles; (8) rear suspension; (9) tracks; (10) shock absorbers; (11) brakes; (12) engines; (13) ignition and…

Services performed by an engineering consultant

International Nuclear Information System (INIS)

Seyffert, L.

1984-01-01

In the near future, services for the nuclear power plants in operation will become particularly important. Already at the present stage, engineering firms contribute to the planning of revisions and repair work, to the design, procurement and project management of new components and subsystems, respectively; they delegate supporting engineering personnel for the execution of in-plant measures, create special EDP software, develop quality assurance systems and work on quality control. This enumeration presents a rough outline of the field of activities, although it is far from complete. Also, the lines are drawn rather artibrarily, leaving out, for instance, the extensive activities in the fields of waste management and fuel management. These are main activities of specialized engineering firms which will be the subject of a future report. (orig.) [de

Mesenchymal stem cells delivered in a microsphere-based engineered skin contribute to cutaneous wound healing and sweat gland repair.

Science.gov (United States)

Huang, Sha; Lu, Gang; Wu, Yan; Jirigala, Enhe; Xu, Yongan; Ma, Kui; Fu, Xiaobing

2012-04-01

Bone-marrow-derived mesenchymal stem cells (BM-MSCs) can contribute to wound healing after skin injury. However, the role of BM-MSCs on repairing skin appendages in renewal tissues is incompletely explored. Moreover, most preclinical studies suggest that the therapeutic effects afforded by BM-MSCs transplantation are short-lived and relatively unstable. To assess whether engrafted bone-marrow-derived mesenchymal stem cells via a delivery system can participate in cutaneous wound healing and sweat-gland repair in mice. For safe and effective delivery of BM-MSCs to wounds, epidermal growth factor (EGF) microspheres were firstly developed to both support cells and maintain appropriate stimuli, then cell-seeded microspheres were incorporated with biomimetic scaffolds and thus fabricated an engineered skin construct with epithelial differentiation and proliferative potential. The applied efficacy was examined by implanting them into excisional wounds on both back and paws of hind legs in mice. After 3 weeks, BM-MSC-engineered skin (EGF loaded) treated wounds exhibited accelerated healing with increased re-epithelialization rates and less skin contraction. Furthermore, histological and immunofluorescence staining analysis revealed sweat glands-like structures became more apparent in BM-MSC-engineered skin (EGF loaded) treated wounds but the number of implanted BM-MSCs were decreased gradually in later phases of healing progression. Our study suggests that BM-MSCs delivered by this EGF microspheres-based engineered skin model may be a promising strategy to repair sweat glands and improve cutaneous wound healing after injury and success in this study might provide a potential benefit for BM-MSCs administration clinically. Copyright © 2012 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

OCRWM Systems Engineering Management Plan (SEMP)

International Nuclear Information System (INIS)

1990-03-01

The Nuclear Waste Policy Act of 1982 established the Office of Civilian Radioactive Waste Management (OCRWM) in the Department of Energy (DOE) to implement a program for the safe and permanent disposal of spent nuclear fuel and high-level radioactive waste. To achieve this objective, the OCRWM is developing an integrated waste-management system consisting of three elements: the transportation system, the monitored retrievable storage (MRS) facility, and the mined geologic disposal system (MGDS). The development of such a system requires management of many diverse disciplines that are involved in research, siting, design, licensing, and external interactions. The purpose of this Systems Engineering Management Plan (SEMP) is to prescribe how the systems-engineering process will be implemented in the development of the waste-management system. Systems engineering will be used by the OCRWM to manage, integrate, and document all aspects of the technical development of the waste-management system and its system elements to ensure that the requirements of the waste-management program are met. It will be applied to all technical activities of the OCRWM program. It will be used by the OCRWM to specify the sequence of technical activities necessary to define the requirements the waste-management system must satisfy, to develop the waste-management system, to relate system elements to each other, and to determine how the waste-management system can be optimized to most effectively satisfy the requirements. Furthermore, systems engineering will be used in the management of Program activities at the program, program-element, and project levels by specifying procedures, studies, reviews, and documentation requirements. 9 refs., 1 fig

Biomaterial-mediated strategies targeting vascularization for bone repair.

Science.gov (United States)

García, José R; García, Andrés J

2016-04-01

Repair of non-healing bone defects through tissue engineering strategies remains a challenging feat in the clinic due to the aversive microenvironment surrounding the injured tissue. The vascular damage that occurs following a bone injury causes extreme ischemia and a loss of circulating cells that contribute to regeneration. Tissue-engineered constructs aimed at regenerating the injured bone suffer from complications based on the slow progression of endogenous vascular repair and often fail at bridging the bone defect. To that end, various strategies have been explored to increase blood vessel regeneration within defects to facilitate both tissue-engineered and natural repair processes. Developments that induce robust vascularization will need to consolidate various parameters including optimization of embedded therapeutics, scaffold characteristics, and successful integration between the construct and the biological tissue. This review provides an overview of current strategies as well as new developments in engineering biomaterials to induce reparation of a functional vascular supply in the context of bone repair.

Scheduling in Engineering, Project, and Production Management

OpenAIRE

Chien-Ho Ko

2015-01-01

This issue presents five papers selected from the 2013 (4th) International Conference on Engineering, Project, and Production Management (EPPM2013) held in Bangkok, Thailand. Three of the papers deal with scheduling problems faced in project and production management, while the remaining two focus on engineering management issues.

Indications for and outcome of primary repair compared with faecal diversion in the management of traumatic colon injury.

Science.gov (United States)

Fouda, E; Emile, S; Elfeki, H; Youssef, M; Ghanem, A; Fikry, A A; Elshobaky, A; Omar, W; Khafagy, W; Morshed, M

2016-08-01

Injuries of the colon are a serious sequel of abdominal trauma owing to the associated morbidity and mortality. This study aims to assess postoperative outcome and complications of faecal diversion and primary repair of colon injuries when applied according to established guidelines for the management of colon injuries. This retrospective study was conducted on 110 patients with colon injuries. Guided by estimation of risk factors, patients were managed either by primary repair alone, repair with proximal diversion or diversion alone. There were 102 (92.7%) male patients and 8 (7.3%) female patients of median age 38 years. Thirty-seven were managed by primary repair and 73 by faecal diversion. Colon injuries were caused by penetrating abdominal trauma in 65 and blunt trauma in 45 patients. Forty-three patients were in shock on admission, and were all managed by faecal diversion. Forty patients developed 84 complications after surgery. Primary repair had a significantly lower complication rate than faecal diversion (P = 0.037). Wound infection was the commonest complication. The overall mortality rate was 3.6%. Primary repair, when employed properly, resulted in a significantly lower complication rate than faecal diversion. Significant predictive factors associated with a higher complication rate were faecal diversion, severe faecal contamination, multiple colon injuries, an interval of more than 12 h after colon injury and shock. Colorectal Disease © 2016 The Association of Coloproctology of Great Britain and Ireland.

Repair and tissue engineering techniques for articular cartilage.

Science.gov (United States)

Makris, Eleftherios A; Gomoll, Andreas H; Malizos, Konstantinos N; Hu, Jerry C; Athanasiou, Kyriacos A

2015-01-01

Chondral and osteochondral lesions due to injury or other pathology commonly result in the development of osteoarthritis, eventually leading to progressive total joint destruction. Although current progress suggests that biologic agents can delay the advancement of deterioration, such drugs are incapable of promoting tissue restoration. The limited ability of articular cartilage to regenerate renders joint arthroplasty an unavoidable surgical intervention. This Review describes current, widely used clinical repair techniques for resurfacing articular cartilage defects; short-term and long-term clinical outcomes of these techniques are discussed. Also reviewed is a developmental pipeline of acellular and cellular regenerative products and techniques that could revolutionize joint care over the next decade by promoting the development of functional articular cartilage. Acellular products typically consist of collagen or hyaluronic-acid-based materials, whereas cellular techniques use either primary cells or stem cells, with or without scaffolds. Central to these efforts is the prominent role that tissue engineering has in translating biological technology into clinical products; therefore, concomitant regulatory processes are also discussed.

Systems engineering management plan

International Nuclear Information System (INIS)

Conner, C.W.

1985-10-01

The purpose of this Systems Engineering Management Plan (SEMP) is to prescribe the systems engineering procedures to be implemented at the Program level and the minimum requirements for systems engineering at the Program-element level. The Program level corresponds to the Director, OCRWM, or to the organizations within OCRWM to which the Director delegates responsibility for the development of the System and for coordinating and integrating the activities at the Program-element level. The Office of Policy and Outreach (OPO) and the Office of Resource Management (ORM) support the Director at the Program level. The Program-element level corresponds to the organizations within OCRWM (i.e., the Office of Geologic Repositories (OGR) and the Office of Storage and Transportation Systems (OSTS)) with overall responsibility for developing the System elements - that is, the mined geologic disposal system (MGDS), monitored retrievable storage (MRS) (if approved by Congress), and the transportation system

ANAESTHETIC CHALLENGES IN THE MANAGEMENT OF PEDIATRIC ENCEPHALOCOELE REPAIR: RETROSPECTIVE CASE SERIES

Directory of Open Access Journals (Sweden)

Ravindra Giri

2015-02-01

Full Text Available INTRODUCTION: Encephalocele is the protrusion of the cranial contents beyond the normal confines of the skull through a defect in the calvarium and is far less common than spinal dysraphism. 1 Anaesthetic challenges in management of occipital meningoencephalocele include securing the airway with intubation in lateral position, intraoperative prone position and its associated complications, careful securing of the endotracheal tube and accurate assessment of blood loss. These babies also have associated congenital anomalie s, gastrointestinal malrotation, renal anomalies, cardiac malformations and tracheoesophageal fistula, making anaesthetic management even more difficult. Meticulous anaesthetic management is crucial for early repair of encephalocoele to prevent any sequel. 2 METHODS: To identify the anaesthetic challenges, perioperative and postoperative complications during encephalocele repair, 20 cases were studied retrospectively from 2012 to 2014 at Department of Anaesthesia , Department of Neurosurgery, MR Medical College, Gulbarga. RESULTS: 20 cases of encephalocoele repair were undertaken during the study period. Out of these 12 (60% were male and 8(40% female. Age range was 1 day to 6 years. Most common type of encephalocele was occipital 12(60%, which posed a difficulty during positioning & intubation, followed by occipito - cervical 4(20%, Parietal 2(10%, Fronto - nasal 1(5% & Fronto - naso - ethmoidal 1(5%. Most of the patients were extubated successfully on table, only one patient required post - operative ventilator support for a day. Peri - operative complications included bronchospasm (15%, followed by hypotension, tachycardia, laryngospasm, hypoxia, accidental extubation (10% each & bradycardia, endobronchial intubation (5%. CONCLUSION: Children with Encephalocoele are prone to have peri - operative complications which can be managed by meticulous anaesthetic managenement. 3 Early surgical management of encephalocoele is not

Performance of Engineered Cementitious Composites for Concrete Repairs

NARCIS (Netherlands)

Zhou, J.

2011-01-01

Background and goals of this thesis The concrete repair, rehabilitation and retrofitting industry grows rapidly, driven by deterioration of, damage to and defects in concrete structures. However, it is well known that to achieve durable concrete repairs is very difficult. The failure of concrete

Cell-based tissue engineering strategies used in the clinical repair of articular cartilage.

Science.gov (United States)

Huang, Brian J; Hu, Jerry C; Athanasiou, Kyriacos A

2016-08-01

One of the most important issues facing cartilage tissue engineering is the inability to move technologies into the clinic. Despite the multitude of current research in the field, it is known that 90% of new drugs that advance past animal studies fail clinical trials. The objective of this review is to provide readers with an understanding of the scientific details of tissue engineered cartilage products that have demonstrated a certain level of efficacy in humans, so that newer technologies may be developed upon this foundation. Compared to existing treatments, such as microfracture or autologous chondrocyte implantation, a tissue engineered product can potentially provide more consistent clinical results in forming hyaline repair tissue and in filling the entirety of the defect. The various tissue engineering strategies (e.g., cell expansion, scaffold material, media formulations, biomimetic stimuli, etc.) used in forming these products, as collected from published literature, company websites, and relevant patents, are critically discussed. The authors note that many details about these products remain proprietary, not all information is made public, and that advancements to the products are continuously made. Nevertheless, by understanding the design and production processes of these emerging technologies, one can gain tremendous insight into how to best use them and also how to design the next generation of tissue engineered cartilage products. Copyright © 2016 Elsevier Ltd. All rights reserved.

Cell-based tissue engineering strategies used in the clinical repair of articular cartilage

Science.gov (United States)

Huang, Brian J.; Hu, Jerry C.; Athanasiou, Kyriacos A.

2016-01-01

One of the most important issues facing cartilage tissue engineering is the inability to move technologies into the clinic. Despite the multitude of review articles on the paradigm of biomaterials, signals, and cells, it is reported that 90% of new drugs that advance past animal studies fail clinical trials (1). The intent of this review is to provide readers with an understanding of the scientific details of tissue engineered cartilage products that have demonstrated a certain level of efficacy in humans, so that newer technologies may be developed upon this foundation. Compared to existing treatments, such as microfracture or autologous chondrocyte implantation, a tissue engineered product can potentially provide more consistent clinical results in forming hyaline repair tissue and in filling the entirety of the defect. The various tissue engineering strategies (e.g., cell expansion, scaffold material, media formulations, biomimetic stimuli, etc.) used in forming these products, as collected from published literature, company websites, and relevant patents, are critically discussed. The authors note that many details about these products remain proprietary, not all information is made public, and that advancements to the products are continuously made. Nevertheless, by fully understanding the design and production processes of these emerging technologies, one can gain tremendous insight into how to best use them and also how to design the next generation of tissue engineered cartilage products. PMID:27177218

Management of failed rotator cuff repair: a systematic review

Science.gov (United States)

Lädermann, Alexandre; Denard, Patrick J; Burkhart, Stephen S

2016-01-01

Importance Recurrent tear after rotator cuff repair (RCR) is common. Conservative, and open and arthroscopic revisions, have been advocated to treat these failures. Aim or objective The purpose of this systematic review was to evaluate the different options for managing recurrent rotator cuff tears. Evidence review A search was conducted of level I through 4 studies from January 2000 to October 2015, to identify studies reporting on failed RCR. 10 articles were identified. The overall quality of evidence was very low. Findings Mid-term to long-term follow-up of patients treated conservatively revealed acceptable results; a persistent defect is a well-tolerated condition that only occasionally requires subsequent surgery. Conservative treatment might be indicated in most patients, particularly in case of posterosuperior involvement and poor preoperative range of motion. Revision surgery might be indicated in a young patient with a repairable lesion, a 3 tendon tear, and in those with involvement of the subscapularis. Conclusions and relevance The current review indicates that arthroscopic revision RCR can lead to improvement in functional outcome despite a high retear rate. Further studies are needed to develop specific rehabilitation in the case of primary rotator cuff failure, to better understand the place of each treatment option, and, in case of repair, to optimise tendon healing. PMID:27134759

Systems Engineering Analysis for Office Space Management

Science.gov (United States)

2017-09-01

ENGINEERING ANALYSIS FOR OFFICE SPACE MANAGEMENT by James E. Abellana September 2017 Thesis Advisor: Diana Angelis Second Reader: Walter E. Owen...Master’s thesis 4. TITLE AND SUBTITLE SYSTEMS ENGINEERING ANALYSIS FOR OFFICE SPACE MANAGEMENT 5. FUNDING NUMBERS 6. AUTHOR(S) James E. Abellana 7...of the systems engineering method, this thesis develops a multicriteria decision-making framework applicable to space allocation decisions for

19th International Congress on Project Management and Engineering

CERN Document Server

Blanco, José; Capuz-Rizo, Salvador

2017-01-01

This book gathers the best papers presented at the 19th International Congress on Project Management and Engineering, which was held in Granada, Spain in July 2015. It covers a range of project management and engineering contexts, including: civil engineering and urban planning, product and process engineering, environmental engineering, energy efficiency and renewable energies, rural development, information and communication technologies, safety, labour risks and ergonomics, and training in project engineering. Project management and engineering is taking on increasing importance as projects continue to grow in size, more stakeholders become involved, and environmental, organisational and technological issues become more complex. As such, this book offers a valuable resource for all professionals seeking the latest material on the changing face of project management.

18th International Congress on Project Management and Engineering

CERN Document Server

Blanco, José; Capuz-Rizo, Salvador

2016-01-01

This volume features papers from the 18th International Congress on Project Management and Engineering, held by the University of Zaragoza in collaboration with the Spanish Association of Project Management and Engineering (AEIPRO). It illustrates the state of the art in this emerging area. Readers will discover ways to increase the effectiveness of project engineering as well as the efficiency of project management. The papers, written by international researchers and professionals, cover civil engineering and urban planning, product and process engineering, environmental engineering, energy efficiency and renewable energies, rural development, safety, labor risks and ergonomics, and training in project engineering. Overall, this book contributes to the improvement of project engineering research and enhances the transfer of results to the job of project engineers and project managers around the world. It will appeal to all professionals in the field as well as researchers and teachers involved in the traini...

Application of repair and maintenance management for SACIA L550-E scrap machines

International Nuclear Information System (INIS)

Ign Dewanto; Tony R, Bambang L

2013-01-01

Scrap machines is one of the mechanical machines that serve to reduce the dimensions of the work piece or can also be used in manufacture of various surface which forms a straight, some square and some kind of groove. This machine is one of the means to provide service and repair facilities manufacture of nuclear component plant. Given the importance of this machine in the mechanical workshop equipment must be kept in prime condition. To support this it is necessary for the maintenance and repair maintenance of the machine is always ready to use and if there is damage, it must be repaired immediately so that the machine has long service life, efficient and effective manner. It required good maintenance management. (author)

Influence of Rotator Cuff Tear Size and Repair Technique on the Creation and Management of Dog Ear Deformities in a Transosseous-Equivalent Rotator Cuff Repair Model

Science.gov (United States)

Redler, Lauren H.; Byram, Ian R.; Luchetti, Timothy J.; Tsui, Ying Lai; Moen, Todd C.; Gardner, Thomas R.; Ahmad, Christopher S.

2014-01-01

Background: Redundancies in the rotator cuff tissue, commonly referred to as “dog ear” deformities, are frequently encountered during rotator cuff repair. Knowledge of how these deformities are created and their impact on rotator cuff footprint restoration is limited. Purpose: The goals of this study were to assess the impact of tear size and repair method on the creation and management of dog ear deformities in a human cadaveric model. Study Design: Controlled laboratory study. Methods: Crescent-shaped tears were systematically created in the supraspinatus tendon of 7 cadaveric shoulders with increasing medial to lateral widths (0.5, 1.0, and 1.5 cm). Repair of the 1.5-cm tear was performed on each shoulder with 3 methods in a randomized order: suture bridge, double-row repair with 2-mm fiber tape, and fiber tape with peripheral No. 2 nonabsorbable looped sutures. Resulting dog ear deformities were injected with an acrylic resin mixture, digitized 3-dimensionally (3D), and photographed perpendicular to the footprint with calibration. The volume, height, and width of the rotator cuff tissue not in contact with the greater tuberosity footprint were calculated using the volume injected, 3D reconstructions, and calibrated photographs. Comparisons were made between tear size, dog ear measurement technique, and repair method utilizing 2-way analysis of variance and Student-Newman-Keuls multiple-comparison tests. Results: Utilizing 3D digitized and injection-derived volumes and dimensions, anterior dog ear volume, height, and width were significantly smaller for rotator cuff repair with peripheral looped sutures compared with a suture bridge (P repair with 2-mm fiber tape alone (P repair with looped peripheral sutures compared with a suture bridge (P repair technique, peripheral No. 2 nonabsorbable looped sutures significantly decreased the volume, height, and width of dog ear deformities, better restoring the anatomic footprint of the rotator cuff. Clinical

Engineering management of large scale systems

Science.gov (United States)

Sanders, Serita; Gill, Tepper L.; Paul, Arthur S.

1989-01-01

The organization of high technology and engineering problem solving, has given rise to an emerging concept. Reasoning principles for integrating traditional engineering problem solving with system theory, management sciences, behavioral decision theory, and planning and design approaches can be incorporated into a methodological approach to solving problems with a long range perspective. Long range planning has a great potential to improve productivity by using a systematic and organized approach. Thus, efficiency and cost effectiveness are the driving forces in promoting the organization of engineering problems. Aspects of systems engineering that provide an understanding of management of large scale systems are broadly covered here. Due to the focus and application of research, other significant factors (e.g., human behavior, decision making, etc.) are not emphasized but are considered.

Ethical Risk Management Education in Engineering: A Systematic Review.

Science.gov (United States)

Guntzburger, Yoann; Pauchant, Thierry C; Tanguy, Philippe A

2017-04-01

Risk management is certainly one of the most important professional responsibilities of an engineer. As such, this activity needs to be combined with complex ethical reflections, and this requirement should therefore be explicitly integrated in engineering education. In this article, we analyse how this nexus between ethics and risk management is expressed in the engineering education research literature. It was done by reviewing 135 articles published between 1980 and March 1, 2016. These articles have been selected from 21 major journals that specialize in engineering education, engineering ethics and ethics education. Our review suggests that risk management is mostly used as an anecdote or an example when addressing ethics issues in engineering education. Further, it is perceived as an ethical duty or requirement, achieved through rational and technical methods. However, a small number of publications do offer some critical analyses of ethics education in engineering and their implications for ethical risk and safety management. Therefore, we argue in this article that the link between risk management and ethics should be further developed in engineering education in order to promote the progressive change toward more socially and environmentally responsible engineering practices. Several research trends and issues are also identified and discussed in order to support the engineering education community in this project.

Systems Maintenance Automated Repair Tasks (SMART)

Science.gov (United States)

Schuh, Joseph; Mitchell, Brent; Locklear, Louis; Belson, Martin A.; Al-Shihabi, Mary Jo Y.; King, Nadean; Norena, Elkin; Hardin, Derek

2010-01-01

SMART is a uniform automated discrepancy analysis and repair-authoring platform that improves technical accuracy and timely delivery of repair procedures for a given discrepancy (see figure a). SMART will minimize data errors, create uniform repair processes, and enhance the existing knowledge base of engineering repair processes. This innovation is the first tool developed that links the hardware specification requirements with the actual repair methods, sequences, and required equipment. SMART is flexibly designed to be useable by multiple engineering groups requiring decision analysis, and by any work authorization and disposition platform (see figure b). The organizational logic creates the link between specification requirements of the hardware, and specific procedures required to repair discrepancies. The first segment in the SMART process uses a decision analysis tree to define all the permutations between component/ subcomponent/discrepancy/repair on the hardware. The second segment uses a repair matrix to define what the steps and sequences are for any repair defined in the decision tree. This segment also allows for the selection of specific steps from multivariable steps. SMART will also be able to interface with outside databases and to store information from them to be inserted into the repair-procedure document. Some of the steps will be identified as optional, and would only be used based on the location and the current configuration of the hardware. The output from this analysis would be sent to a work authoring system in the form of a predefined sequence of steps containing required actions, tools, parts, materials, certifications, and specific requirements controlling quality, functional requirements, and limitations.

Lifecycle management for nuclear engineering project documents

International Nuclear Information System (INIS)

Zhang Li; Zhang Ming; Zhang Ling

2010-01-01

The nuclear engineering project documents with great quantity and various types of data, in which the relationships of each document are complex, the edition of document update frequently, are managed difficultly. While the safety of project even the nuclear safety is threatened seriously by the false documents and mistakes. In order to ensure the integrality, veracity and validity of project documents, the lifecycle theory of document is applied to build documents center, record center, structure and database of document lifecycle management system. And the lifecycle management is used to the documents of nuclear engineering projects from the production to pigeonhole, to satisfy the quality requirement of nuclear engineering projects. (authors)

International Asia Conference on Industrial Engineering and Management Innovation

CERN Document Server

Shen, Jiang; Dou, Runliang

2013-01-01

The International Conference on Industrial Engineering and Engineering Management is sponsored by the Chinese Industrial Engineering Institution, CMES, which is the only national-level academic society for Industrial Engineering. The conference is held annually as the major event in this arena. Being the largest and the most authoritative international academic conference held in China, it provides an academic platform for experts and entrepreneurs in the areas of international industrial engineering and management to exchange their research findings. Many experts in various fields from China and around the world gather together at the conference to review, exchange, summarize and promote their achievements in the fields of industrial engineering and engineering management. For example, some experts pay special attention to the current state of the application of related techniques in China as well as their future prospects, such as green product design, quality control and management, supply chain and logist...

Biomimetic strategies for fracture repair: engineering the cell microenvironment for directed tissue formation

OpenAIRE

Vas, Wollis J.; Shah, Mittal; Al Hosni, Rawiya; Owen, Helen C.; Roberts, Scott J.

2017-01-01

Complications resulting from impaired fracture healing have major clinical implications on fracture management strategies. Novel concepts taken from developmental biology have driven research strategies towards the elaboration of regenerative approaches that can truly harness the complex cellular events involved in tissue formation and repair. Advances in polymer technology and a better understanding of naturally derived scaffolds have given rise to novel biomaterials with an increasing abili...

Engineering Change Management Method Framework in Mechanical Engineering

Science.gov (United States)

Stekolschik, Alexander

2016-11-01

Engineering changes make an impact on different process chains in and outside the company, and lead to most error costs and time shifts. In fact, 30 to 50 per cent of development costs result from technical changes. Controlling engineering change processes can help us to avoid errors and risks, and contribute to cost optimization and a shorter time to market. This paper presents a method framework for controlling engineering changes at mechanical engineering companies. The developed classification of engineering changes and accordingly process requirements build the basis for the method framework. The developed method framework comprises two main areas: special data objects managed in different engineering IT tools and process framework. Objects from both areas are building blocks that can be selected to the overall business process based on the engineering process type and change classification. The process framework contains steps for the creation of change objects (both for overall change and for parts), change implementation, and release. Companies can select singleprocess building blocks from the framework, depending on the product development process and change impact. The developed change framework has been implemented at a division (10,000 employees) of a big German mechanical engineering company.

Understanding the management and teaching of dental restoration repair: Systematic review and meta-analysis of surveys.

Science.gov (United States)

Kanzow, Philipp; Wiegand, Annette; Göstemeyer, Gerd; Schwendicke, Falk

2018-02-01

Repair instead of complete replacement is recommended to manage partially defective restorations. It is unclear if and why such treatment is taught at dental schools or practiced by dentists. We aimed to identify barriers and facilitators for repairs using a systematic review and meta- and qualitative analysis. Electronic databases (PubMed, CENTRAL, Embase, PsycINFO) were searched. Quantitative studies reporting on the proportion of (1) dentists stating to perform repairs, (2) dental schools teaching repairs, (3) failed restorations having been repaired were included. We also included qualitative studies on barriers/facilitators for repairs. Random-effects meta-analyses, meta-regression and a thematic analysis using the theoretical domains framework were conducted. 401 articles were assessed and 29, mainly quantitative, studies included. 7228 dentists and 276 dental schools had been surveyed, and treatment data of 30,172 restorations evaluated. The mean (95% CI) proportion of dentists stating to perform repairs was 71.5% (49.7-86.4%). 83.3% (73.6-90.0%) of dental schools taught repairs. 31.3% (26.3-36.7%) of failed restorations had been repaired. More recent studies reported significantly more dentists to repair restorations (p=0.004). Employment in public health practices and being the dentist who placed the original restoration were facilitators for repairs. Amalgam restorations were repaired less often, and financial aspects and regulations came as barriers. While most dentists state to perform repairs and the vast majority of dental schools teach repairs, the proportion of truly repaired restorations was low. A number of interventions to implement repair in dental practice can be deduced from our findings. Partially defective restorations are common in dental practice. While repairs are taught and dentists are aware of the recommendation towards repairs, the actually performed proportion of repairs seems low. Copyright © 2017 Elsevier Ltd. All rights reserved.

7th World Congress on Engineering Asset Management

CERN Document Server

Choi, Byeongkuen; Ma, Lin; Mathew, Joseph

2015-01-01

These proceedings comprise 60 refereed papers of the Seventh World Congress on Engineering Asset Management (WCEAM) that was held in Deajeon City, Korea from 8-9 October 2012. The material is a compilation of state-of-the-art papers in the field covering a comprehensive range of subjects that are equally relevant to business managers and engineering professionals alike. Proceedings of the 7th World Congress on Engineering Asset Management (WCEAM 2012): Towards Integration and Interoperability in EAM covers a wide range of topics in the discipline of engineering asset management, including: ·         strategic asset management ·         condition monitoring and diagnostics ·         integrated intelligent maintenance ·         sensors and devices ·         information quality & management; ·         sustainability in asset management ·         asset performance and knowledge management ·         data mining and AI techniques in asset m...

Quality of Postoperative Pain Management After Maxillofacial Fracture Repair.

Science.gov (United States)

Peisker, Andre; Meissner, Winfried; Raschke, Gregor F; Fahmy, Mina D; Guentsch, Arndt; Schiller, Juliane; Schultze-Mosgau, Stefan

2018-05-01

Effective pain management is an essential component in the perioperative care of surgical patients. However, postoperative pain after maxillofacial fracture repair and its optimal therapy has not been described in detail. In a prospective cohort study, 95 adults rated their pain on the first postoperative day after maxillofacial fracture repair using the questionnaire of the Quality Improvement in Postoperative Pain Management (QUIPS) project. Quality Improvement in Postoperative Pain Management allowed for a standardized assessment of patients' characteristics and pain-related parameters. Overall, the mean maximal pain and pain on activity (numeric rating scales) were significantly higher in patients with mandibular fractures than in patients with midface fractures (P = 0.002 and P = 0.045, respectively). In patients with mandibular fractures, a longer duration of surgery was significantly associated with higher satisfaction with pain intensity (P = 0.015), but was more frequently associated with postoperative vomiting (P = 0.023). A shorter duration of surgery and an absence of preoperative pain counseling in these patients were significantly correlated to desire for more pain medication (P = 0.049 and P = 0.004, respectively). Patients with mandibular fractures that received opioids in the recovery room had significantly higher strain-related pain (P = 0.017). In patients with midface fractures, a longer duration of surgery showed significantly higher levels of decreased mobility (P = 0.003). Patients receiving midazolam for premedication had significantly less minimal pain (P = 0.021). Patients with mandibular fractures seem to have more postoperative pain than patients with midface fractures. Monitoring of postsurgical pain and a procedure-specific pain-treatment protocol should be performed in clinical routine.

Systems engineering management plan for the Salt Repository Project

International Nuclear Information System (INIS)

Neff, J.O.

1986-08-01

This document presents the plan for using systems engineering in conducting and managing the technical work of the Salt Repository Project (SRP) of the US Department of Energy's Civilian Radioactive Waste Management Program. The need for preparing a Systems Engineering Management Plan (SEMP) is traced back to relevant DOE directives. These directives are interpreted as SRP requirements in the context of the Mined Geologic Disposal System. The strategy for conducting systems engineering on the SRP, including the role of the systems engineering process, is then described. The SEMP also designates who in the project organization will be responsible for carrying out the activities. Finally, the management tools that are used to implement the systems engineering process, including associated documentation on the SRP, are described

6th World Congress on Engineering Asset Management

CERN Document Server

Ni, Jun; Sarangapani, Jagnathan; Mathew, Joseph

2014-01-01

This text represents state-of-the-art trends and developments in the emerging field of engineering asset management as presented at the Sixth World Congress on Engineering Asset Management (WCEAM) held in Cincinnati, OH, USA from October 3-5, 2011 The Proceedings of the WCEAM 2011 is an excellent reference for practitioners, researchers and students in the multidisciplinary field of asset management, covering topics such as: • Asset condition monitoring and intelligent maintenance • Asset data warehousing, data mining and fusion • Asset performance and level-of-service models • Design and lifecycle integrity of physical assets • Deterioration and preservation models for assets • Education and training in asset management • Engineering standards in asset management • Fault diagnosis and prognostics • Financial analysis methods for physical assets • Human dimensions in integrated asset management • Information quality management • Information systems and knowledge management • Intellig...

Tank waste remediation system systems engineering management plan

International Nuclear Information System (INIS)

Peck, L.G.

1998-01-01

This Systems Engineering Management Plan (SEMP) describes the Tank Waste Remediation System (TWRS) implementation of the US Department of Energy (DOE) systems engineering policy provided in 97-IMSD-193. The SEMP defines the products, process, organization, and procedures used by the TWRS Project to implement the policy. The SEMP will be used as the basis for tailoring the systems engineering applications to the development of the physical systems and processes necessary to achieve the desired end states of the program. It is a living document that will be revised as necessary to reflect changes in systems engineering guidance as the program evolves. The US Department of Energy-Headquarters has issued program management guidance, DOE Order 430. 1, Life Cycle Asset Management, and associated Good Practice Guides that include substantial systems engineering guidance

Concrete structures protection, repair and rehabilitation

CERN Document Server

Woodson, R Dodge

2009-01-01

The success of a repair or rehabilitation project depends on the specific plans designed for it. Concrete Structures: Protection, Repair and Rehabilitation provides guidance on evaluating the condition of the concrete in a structure, relating the condition of the concrete to the underlying cause or causes of that condition, selecting an appropriate repair material and method for any deficiency found, and using the selected materials and methods to repair or rehabilitate the structure. Guidance is also provided for engineers focused on maintaining concrete and preparing concrete investigation r

Waste management in the nuclear engineering curriculum

International Nuclear Information System (INIS)

Tulenko, J.S.

1989-01-01

One of the most significant challenges facing the nuclear industry is to successfully close the nuclear fuel cycle and effectively demonstrate to the public that nuclear wastes do not present a health risk. This issue is currently viewed by many as the most important issue affecting public acceptance of nuclear power, and it is imperative that nuclear engineers be able to effectively address the question of nuclear waste from both a generation and disposal standpoint. To address the issue, the area of nuclear waste management has been made one of the fields of specialized study in the Department of Nuclear Engineering Sciences at the University of Florida. The study of radioactive waste management at the University of Florida is designed both for background for the general nuclear engineering student and for those wishing to specialize in it as a multidiscipline study area involving the Departments of Nuclear Engineering Sciences, Environmental Sciences, Material Science and Engineering, Geology, Civil Engineering, and Industrial Engineering

Developing excellence awareness at Davis-Besse through engineering quality management

International Nuclear Information System (INIS)

Gaudette, M.R.; Lash, J.H.; Haiman, D.L.

1989-01-01

At Davis-Besse nuclear power station engineering quality management includes a variety of chartered functions whose ultimate objective is to improve product and service quality and process efficiency. These functions were assigned in late 1988 to engineering assurance personnel, a section of the engineering department which reports directly to the engineering director but is independent of design activities. This independence ensures objectivity and allows the improvement process to span functional areas so that changes made in one engineering section do not negatively impact the activities of another section. The engineering quality management functions performed by the engineering assurance group are summarized. Engineering quality management at Davis-Besse has increased the degree of excellence evident in engineering products and services

Dynamic process management for engineering environments

NARCIS (Netherlands)

Mentink, R.J.; van Houten, Frederikus J.A.M.; Kals, H.J.J.

2003-01-01

The research presented in this paper proposes a concept for dynamic process management as part of an integrated approach to engineering process support. The theory of information management is the starting point for the development of a process management system based on evolution of information

Engineering endostatin-producing cartilaginous constructs for cartilage repair using nonviral transfection of chondrocyte-seeded and mesenchymal-stem-cell-seeded collagen scaffolds.

Science.gov (United States)

Jeng, Lily; Olsen, Bjorn R; Spector, Myron

2010-10-01

Although there is widespread recognition of the importance of angiogenesis in tissue repair, there is little work on the inhibition of angiogenesis in the context of tissue engineering of naturally avascular tissues, like articular cartilage. The objective was to engineer a collagen-scaffold-based cartilaginous construct overexpressing a potent antiangiogenic factor, endostatin, using nonviral transfection. Endostatin-plasmid-supplemented collagen scaffolds were seeded with mesenchymal stem cells and chondrocytes and cultured for 20–22 days. The effects of the following variables on endostatin expression and chondrogenesis were examined: collagen scaffold material, method of nonviral vector incorporation, plasmid load, culture medium, and oxygen tension. An increase and peak of endostatin protein was observed during the first week of culture, followed by a decrease to low levels, suggesting that overexpression of endostatin could be sustained for several days using the nonviral vector. The amount of endostatin produced was tunable with the external factors. Chondrogenesis was observed in the engineered constructs cultured in chondrogenic medium at the 3-week time point, demonstrating that endostatin did not inhibit the chondrogenic potential of mesenchymal stem cells or the general viability of the cells. The ability to engineer endostatin-expressing cartilaginous constructs will be of value for future work exercising regulatory control of angiogenesis in cartilage repair.

OCRWM [Office of Civilian Radioactive Waste Management] System Engineering Management Plant (SEMP)

International Nuclear Information System (INIS)

1990-02-01

The Nuclear Waste Policy Act of 1982 established the Office of Civilian Radioactive Waste Management (OCRWM) in the Department of Energy (DOE) to implement a program for the safe and permanent disposal of spent nuclear fuel and high-level radioactive waste. To achieve this objective, the OCRWM is developing an integrated waste-management system consisting of three elements: the transportation system, the monitored retrievable storage (MRS) facility, and the mined geologic disposal system (MGDS). The development of such a system requires management of many diverse disciplines that are involved in research, siting, design, licensing, and external interactions. The purpose of this Systems Engineering Management Plan (SEMP) is to prescribe how the systems-engineering process will be implemented in the development of the waste-management system. Systems engineering will be used by the OCRWM to manage, integrate, and document all aspects of the technical development of the waste-management system and its system elements to ensure that the requirements of the waste-management program are met. It will be applied to all technical activities of the OCRWM program. It will be used by the OCRWM (1) to specify the sequence of technical activities necessary to define the requirements the waste-management system must satisfy, (2) to develop the waste-management system, can be optimized to most effectively satisfy the requirements. Furthermore, systems engineering will be used in the management of Program activities at the program, program-element, and project levels by specifying procedures, studies, reviews, and documentation requirements. 9 refs., 1 fig

Engineering dextran-based scaffolds for drug delivery and tissue repair

Science.gov (United States)

Sun, Guoming; Mao, Jeremy J

2015-01-01

Owing to its chemically reactive hydroxyl groups, dextran can be modified with different functional groups to form spherical, tubular and 3D network structures. The development of novel functional scaffolds for efficient controlled release and tissue regeneration has been a major research interest, and offers promising therapeutics for many diseases. Dextran-based scaffolds are naturally biodegradable and can serve as bioactive carriers for many protein biomolecules. The reconstruction of the in vitro microenvironment with proper signaling cues for large-scale tissue regenerative scaffolds has yet to be fully developed, and remains a significant challenge in regenerative medicine. This paper will describe recent advances in dextran-based polymers and scaffolds for controlled release and tissue engineering. Special attention is given to the development of dextran-based hydrogels that are precisely manipulated with desired structural properties and encapsulated with defined angiogenic growth factors for therapeutic neovascularization, as well as their potential for wound repair. PMID:23210716

Engineering Documentation Control Handbook Configuration Management and Product Lifecycle Management

CERN Document Server

Watts, Frank B

2011-01-01

In this new edition of his widely-used Handbook, Frank Watts, widely recognized for his significant contributions to engineering change control processes, provides a thoroughly practical guide to the implementation and improvement of Engineering Documentation Control (EDC), Product Lifecycle Management and Product Configuration Management (CM). Successful and error-free implementation of EDC/CM is critical to world-class manufacturing. Huge amounts of time are wasted in most product manufacturing environments over EDC/CM issues such as interchangeability, document release and change control -

MANAGING CONFLICT IN ENGINEERING PROJECTS: NEW ZEALAND EXPERIENCES

Directory of Open Access Journals (Sweden)

Nicola Naismith

2016-07-01

Full Text Available There is a wealth of knowledge concerning conflict management and its resolution in the workplace, however there is a dearth of information relating to conflict management and its resolution in engineering project management. This paper set out to examine the reality of conflict management in engineering project management in New Zealand. This was achieved through a review of credible literature sources and the completion of a pilot study to gain subject matter expert perspectives. The research suggests that conflicts can be destructive, resulting in anxiety and strong emotional responses leading to reflexive reactions including avoidance, aggression, fight, hostility and a breakdown in communications and relationships. Findings indicate that managing a project structure is synonymous with handling conflict and these disagreements can be detrimental to the success of a project. The initial results suggest that a number of factors act as drivers of conflict in engineering projects in New Zealand. These drivers are: power, personality, group dynamics and organisation culture. The conflict resolution tools cited as being widely used for engineering projects are collaboration and negotiation. The paper also offers recommendations for future research.

10th World Congress on Engineering Asset Management

CERN Document Server

Kortelainen, Helena; Aaltonen, Jussi; Uusitalo, Teuvo; Komonen, Kari; Mathew, Joseph; Laitinen, Jouko

2016-01-01

This book comprises refereed papers from the 10th World Congress on Engineering Asset Management (WCEAM 2015), held in Tampere, Finland in September 2015. These proceedings include a compilation of state-of-the-art papers covering a comprehensive range of subjects equally relevant to business managers and engineering professionals alike. With a focus on various aspects of engineering asset management ranging from strategic level issues to detail-level machine health issues, these papers address both industry and public sector concerns and issues, as well as advanced academic research. Proceedings of the WCEAM 2015 is an excellent reference and resource for asset management practitioners, researchers and academics, as well as undergraduate and postgraduate students at tertiary institutions or in the industry.

Construction Management of Electromechanical Engineering Project in Petrochemical Construction

Directory of Open Access Journals (Sweden)

Xi Tao

2017-03-01

Full Text Available Petrochemical industry as a basic industry, occupies a pivotal position in the national economy, with the continuous development of science and technology, electromechanical automation in the petrochemical industry has been widely used to save a lot of labor but also greatly improve the oil Chemical industry production efficiency. Therefore, in the construction of petrochemical industry, mechanical and electrical engineering as part of it. It plays a vital role. Petrochemical industry with the production of high temperature and high pressure and flammable and explosive gas, can strengthen the construction of mechanical and electrical engineering specialization and construction management of scientific, has become the relationship between the smooth development of mechanical and electrical engineering and engineering quality of the key, A direct impact on the petrochemical construction of the overall construction quality. To this end, it is necessary for the construction of petrochemical construction of electromechanical engineering construction management to promote the construction of mechanical and electrical engineering management level gradually increased. This article on the machine Electric engineering project construction management were discussed with a view to the petrochemical construction in the relevant aspects of the need to provide reference for reference.

Flexible Software Solution for Information System of Maintenance and Repair in Armenian NPP Medzamor

International Nuclear Information System (INIS)

Stoilova Yordanova, V.; Manchev, B.

2016-01-01

Achieving high performance in maintenance and repair activities in nuclear facilities and good results in this area is not possible without proper planning. This includes long-term, medium-term and annual planning. A computerized information maintenance management system is a tool widely used by nuclear operators to achieve safe, reliable, stable and predictable plant operation. Development and implementation of such a system in the Armenian NPP Medzamor (ANPP) was initiated by the European Commission (EC) in August 2013 based on the decision of ANPP management to improve practice in terms of planning and carrying out maintenance and repair of plant structures, systems and components (SSCs). The main purpose for the development and deployment of information maintenance management system in ANPP is creation of a systematic approach to the distribution of tasks between the maintenance personnel as well as the timing and methods of their implementation - on which systems, structures and components, maintenance frequency, while the ultimate goal is to optimize the use of resources for maintenance and to ensure plant safe operation and reliability. In November 2013 a contract between European Commission and consortium Risk Engineering -David Holding was signed, including the following supplies: Hardware for the information system of ANPP (called us Archimed MRO); Specification, design and development of the software of Archimed MRO, installation of the system, data migration, training of ANPP staff operating the system, and 9 months trial operation. In the process of specifying the functionality of the system the main purpose was to provide modern information tools to help improve the work of ANPP personnel in the following areas: Optimization of ANPP maintenance program; Planning of maintenance, repair and overhaul (MRO) activities; Effective management of the processes of MRO; Analysis of the MRO results (trend analysis, recurrence of repairs, quality of the repairs

Proceedings of the Sixth International Conference on Management Science and Engineering Management : Focused on Electrical and Information Technology

CERN Document Server

Yasinzai, Masoom; Lev, Benjamin

2013-01-01

Welcome to the proceedings of the Sixth International Conference on Management Science and Engineering Management (ICMSEM2012) held from November 11 to 14, 2012 at Quaid-i-Azam University, Islamabad, Pakistan and supported by Sichuan University (Chengdu, China), Quaid-i-Azam University (Islamabad, Pakistan) and The National Natural Science Foundation of China. The International Conference on Management Science and Engineering Management is the annual conference organized by the International Society of Management Science and Engineering Management. The goals of the Conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current research results. The papers are classified into 8 sections: Computer and Networks, Information Technology, Decision Support System, Industrial Engineering, Supply Chain Management, Project Management, Manufacturing and Ecological Engineering. The key issues of the sixth ICMSEM cover variou...

HIGH SERVE '90 - nuclear engineering services

International Nuclear Information System (INIS)

Bauer, K.G.

1991-01-01

Nuclear engineering services do not start only with maintenance or repair, but already with the early detection of imminent problems long before they become problems. Services concerning the decommissioning of plants also belong to it. A selection of the extraordinary services rendered nowadays is presented in more than 20 papers in this booklet. These papers may roughly be divided into three groups of subjects: monitoring and operational management; maintenance, repair and improvements; radioactive waste treatment and management. The first group of subjects, in particular, covers papers dealing with early detection, monitoring and diagnosing systems, using highly advanced hard- and software technologies. Modernization of instrumentation and control systems and exchange of process computer systems is another task this service has to accomplish. Process computers of the past have developed into high performance process information systems. (orig./DG) [de

Intercultural Communication in Management of Engineering and Technology

Science.gov (United States)

Miyoshi, Kazuhisa

Companies want more business-minded industrial technology managers and engineers with entrepreneurial skills who also have an awareness of the challenges of global marketplace. Both the Master of Engineering and Management Degree (MEM) and the Master of Management of Technology Degree (MOT) aim to meet the needs of industry by offering managers and engineers the critical skills need to be successful in a professional career. The world today is characterized by an ever-growing number of contacts resulting in communication between people in industry with different linguistic and cultural backgrounds. This communication takes place because of contacts within the areas of business, engineering, technology, science, and education but also because of immigration brought about by labor shortage or political conflicts. In all these contacts, there is communication, which needs to be as constructive as possible, without misunderstandings and breakdowns. Knowledge on the nature of linguistic and cultural similarities and differences can play a positive and constructive role. The objective of this paper is to examine what makes the difference in communication between people with diverse cultural background. In addition, it emphasizes the importance of diversity management and diversity leadership in the diverse workplace.

A Curriculum of Value Creation and Management in Engineering

Science.gov (United States)

Yannou, Bernard; Bigand, Michel

2004-01-01

As teachers and researchers belonging to two sister French engineering schools, we are convinced that the processes of value creation and management are essential in today's teaching of industrial engineering and project managers. We believe that such processes may be embedded in a three-part curriculum composed of value management and innovation…

Visual study of capabilities of managing IC engine filling degree vs engine ecological indicators

Science.gov (United States)

Kołodziej, Szymon; Ligus, Grzegorz

2017-10-01

The operation of an internal combustion engine in a transient state is related to constant changes in cylinder filling degree. Managing a steady course of engine torque demands constant corrections in the volume of air delivered to the engine. In this work, different engine throttle management strategies were analyzed. The effect of throttle velocity on emissions was depicted. The research has shown that the greatest value of work density is reached by the IC engine for relatively low values of throttle angle. For shown values, disturbances in air flow in engine intake which may adversely affect emissions due to uneven cylinder filling were researched with the use of Digital Particle Image Velocimetry. The conducted research has shown significant unevennes in air supply to individual cylinders in the engine. This effect may cause discrepancies in air excess ratio for each cylinder, and result in heightened harmful substance emission.

Healthcare Technology Management (HTM) of mechanical ventilators by clinical engineers

OpenAIRE

Yoshioka, Jun; Nakane, Masaki; Kawamae, Kaneyuki

2014-01-01

Mechanical ventilator failures expose patients to unacceptable risks, and maintaining mechanical ventilator safety is an important issue. We examined the usefulness of maintaining mechanical ventilators by clinical engineers (CEs) using a specialized calibrator. These evaluations and the ability to make in-house repairs proved useful for obviating the need to rent ventilators which, in turn, might prove faulty themselves. The CEs' involvement in maintaining mechanical ventilators is desirable...

Engineering management and innovation

Science.gov (United States)

Graham, R. W.

1980-01-01

Although improved management methods can enhance the performance of some enterprises, they can lower that of research organizations. The prevalent use of cost-effectiveness criteria as a management tool overvalues identifiable short-term accomplishment at the expense of long-term research efforts, which often serve as the antecedents upon which a new, seemingly unrelated technology is later founded. Medical instruments used in the treatment of emphysema, for example, evolved from NASA-sponsored research devoted to the measurement of the composition of the atmospheres of the planets. The best manager is the manager who creates an environment that enables his research engineers to pursue ideas with a minimum of interference. Such an environment consists of broad research objectives, adequate facilities, and proper technical support. Within a framework of prudent spending, the manager's aim is to cultivate innovation.

46 CFR 97.30-1 - Repairs to boilers and pressure vessels.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Repairs to boilers and pressure vessels. 97.30-1 Section... VESSELS OPERATIONS Reports of Accidents, Repairs, and Unsafe Equipment § 97.30-1 Repairs to boilers and pressure vessels. (a) Before making any repairs to boilers or unfired pressure vessels, the chief engineer...

46 CFR 196.30-1 - Repairs to boilers and pressure vessels.

Science.gov (United States)

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Repairs to boilers and pressure vessels. 196.30-1... VESSELS OPERATIONS Reports of Accidents, Repairs, and Unsafe Equipment § 196.30-1 Repairs to boilers and pressure vessels. (a) Before making any repairs to boilers or unfired pressure vessels, the Chief Engineer...

46 CFR 78.33-1 - Repairs of boiler and pressure vessels.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Repairs of boiler and pressure vessels. 78.33-1 Section... OPERATIONS Reports of Accidents, Repairs, and Unsafe Equipment § 78.33-1 Repairs of boiler and pressure vessels. (a) Before making any repairs to boilers or unfired pressure vessels, the chief engineer shall...

Mississippi Curriculum Framework for Diesel Equipment Repair & Service (Program CIP: 47.0605--Diesel Engine Mechanic & Repairer). Secondary Programs.

Science.gov (United States)

Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for diesel engine mechanics I and II. Presented first are a program…

Complexity management in engineering design a primer

CERN Document Server

Maurer, Maik

2017-01-01

The treatise supports understanding the phenomena of complexity in engineering, distinguishes complexity from other challenges and presents an overview of definitions and applied approaches. The historical background of complexity management is explained by highlighting the important epochs, their key actors and their discoveries, findings and developments. Knowing about the appearance of early system awareness in ancient Greece, the creation of mechanical philosophy in the 17th century and the discovery of classic physics enables the reader to better comprehend modern system sciences and management approaches. A classification of complexity management approaches by research fields indicates current focus areas and starting points for future discussions. In a comprehensive map, the classification points out mutual overlaps between engineering disciplines in terms of similar complexity management approaches. Finally, the treatise introduces a generic complexity management framework, which is based on structura...

System Reliability Engineering

International Nuclear Information System (INIS)

Lim, Tae Jin

2005-02-01

This book tells of reliability engineering, which includes quality and reliability, reliability data, importance of reliability engineering, reliability and measure, the poisson process like goodness of fit test and the poisson arrival model, reliability estimation like exponential distribution, reliability of systems, availability, preventive maintenance such as replacement policies, minimal repair policy, shock models, spares, group maintenance and periodic inspection, analysis of common cause failure, and analysis model of repair effect.

Information Technology in Engineering and Project Management

Directory of Open Access Journals (Sweden)

Chien-Ho Ko

2017-01-01

Full Text Available Information Technology (IT can be regarded as the use of computers to store, analyze, and manipulate data (Daintith, 2009. With the rapid development of personal computers, IT has been widely applied in nearly every field (Davenport, 2013. This issue presents five papers covering engineering and project management, three of which focus on the application of IT to solve engineering and project management issues, while one presents research into public private partnerships, and another into cash flow forecasting.

Connecting engineering operations to strategic management: a framework for decision making in engineering offshoring

DEFF Research Database (Denmark)

Hansen, Zaza Nadja Lee; Ahmed-Kristensen, Saeema

2012-01-01

of the organisation. The Global Decision-Making (GDM) framework described here is a decision-making framework for engineering offshoring decisions for product development activities. The framework proposes that risks in engineering offshoring can be reduced by connecting engineering operations to strategic management...

Applied engineering fundamentals: The transition from novice to engineering manager

International Nuclear Information System (INIS)

Murawski, M.N.; Tomchin, E.M.

1992-01-01

This paper describes the development and implementation of Applied Engineering Fundamentals, a course designed for newly graduated engineers and scientists serving as technical interns within the US Department of Energy (DOE). As specialists with varying undergraduate and graduate degrees, interns need further training to prepare them for the multidisciplinary environments they will encounter as they become engineering managers. This course is designed to build on individuals strengths in diverse engineering and scientific disciplines, provide instruction in less familiar disciplines, and develop skills in integrating multiple disciplines to solve real-world problems related to nuclear facilities. The course balances systems thinking with state-of-the-art approaches to curriculum development to provide training in technical content and to foster development of professional skills

Mechanical engineers' handbook, manufacturing and management

CERN Document Server

Kutz, Myer

2015-01-01

Full coverage of manufacturing and management in mechanicalengineering Mechanical Engineers' Handbook, Fourth Edition provides aquick guide to specialized areas that engineers may encounter intheir work, providing access to the basics of each and pointingtoward trusted resources for further reading, if needed. The book'saccessible information offers discussions, examples, and analysesof the topics covered, rather than the straight data, formulas, andcalculations found in other handbooks. No single engineer can be aspecialist in all areas that they are called upon to work in. It'sa discipline

A cylinder pressure based engine management system

Energy Technology Data Exchange (ETDEWEB)

Truscott, A.; Noble, A. [Ricardo Consulting Engineers Ltd. (United Kingdom); Mueller, R.; Hart, M.; Kroetz, G.; Eickhoff, M. [DaimlerChrysler AG (Germany); Cavalloni, C.; Gnielka, M. [Kistler Instrumente AG (Switzerland)

2000-07-01

Worldwide demands on fuel economy and lower emissions from automotive vehicles have led to stringent requirements in the development of Engine Management Systems (EMS). Cylinder Pressure based Engine Management Systems (CPEMS) provide a way forward in EMS technology by combining intelligent control algorithms with innovative sensing techniques. The full utilisation of model-based control and diagnostics to provide improvements in cost, efficiency, emissions and comfort requires the close monitoring of engine conditions. This is made possible with the advent of new inexpensive sensor materials that can withstand the harsh environment of the combustion chamber. AENEAS is a collaborative project undertaken by Ricardo, DaimlerChrysler and Kistler, with financial support from the European Commission and the Swiss Government, aimed at demonstrating the major benefits of CPEMS technology. This paper describes the application of CPEMS technology to a spark ignition (SI) engine. It describes how the combination of model based algorithms, incorporating physical principles, and cylinder pressure sensing can provide an effective means of engine control and diagnostics. Results are presented to demonstrate the benefits of this new technology. (author)

The 23rd Annual Meeting of the European Tissue Repair Society (ETRS) in Reims, France

DEFF Research Database (Denmark)

Von den Hoff, Johannes W; Ågren, Sven Per Magnus; Coulomb, Bernard

2014-01-01

The 23rd Annual Meeting of the European Tissue Repair Society, Reims, France, October 23 to 25, 2013 focused on tissue repair and regenerative medicine covering topics such as stem cells, biomaterials, tissue engineering, and burns.......The 23rd Annual Meeting of the European Tissue Repair Society, Reims, France, October 23 to 25, 2013 focused on tissue repair and regenerative medicine covering topics such as stem cells, biomaterials, tissue engineering, and burns....

Integration of project management and systems engineering: Tools for a total-cycle environmental management system

International Nuclear Information System (INIS)

Blacker, P.B.; Winston, R.

1997-01-01

An expedited environmental management process has been developed at the Idaho National Engineering and Environmental Laboratory (INEEL). This process is one result of the Lockheed Martin commitment to the US Department of Energy to incorporate proven systems engineering practices with project management and program controls practices at the INEEL. Lockheed Martin uses a graded approach of its management, operations, and systems activities to tailor the level of control to the needs of the individual projects. The Lockheed Martin definition of systems engineering is: ''''Systems Engineering is a proven discipline that defines and manages program requirements, controls risk, ensures program efficiency, supports informed decision making, and verifies that products and services meet customer needs.'''' This paper discusses: the need for an expedited environmental management process; how the system was developed; what the system is; what the system does; and an overview of key components of the process

Management of Labor and Delivery After Fetoscopic Repair of an Open Neural Tube Defect.

Science.gov (United States)

Kohn, Jaden R; Rao, Vibha; Sellner, Allison A; Sharhan, Dina; Espinoza, Jimmy; Shamshirsaz, Alireza A; Whitehead, William E; Belfort, Michael A; Sanz Cortes, Magdalena

2018-06-01

To report labor, delivery, and neonatal outcomes in a cohort of women delivering neonates who had undergone fetoscopic neural tube defect repair. We conducted a retrospective cohort study from April 2014 to January 2018. All patients met Management of Myelomeningocele Study eligibility criteria. We included patients with completed second-trimester fetoscopic neural tube defect repair (laparotomy, uterine exteriorization, and minimally invasive access through two or three uterine ports) followed by standardized management of labor and delivery at our institution. Outcomes included rates of vaginal delivery, term delivery, and intrapartum cesarean delivery as well as obstetric and neonatal outcomes after oxytocin. Complications of interest included preterm prelabor rupture of membranes, chorioamnionitis, uterine dehiscence or rupture, 5-minute Apgar score less than 7, and neonatal acidosis (umbilical artery pH less than 7.15). Thirty-four patients had fetoscopic repair, followed by 17 vaginal deliveries (50%, 95% CI 32-68%). Median gestational age was 38 1/7 weeks at vaginal delivery (range 26 0/7-40 2/7 weeks of gestation) and 37 1/7 weeks of gestation at cesarean delivery (range 25 5/7-40 5/7 weeks of gestation); 62% of deliveries occurred at term. Eight patients had prelabor cesarean delivery: three nonurgent and five urgent (for nonreassuring fetal heart tracings). Twenty-six patients labored; six were induced and 20 labored spontaneously. Of the latter, five were augmented. Of 26 laboring patients, 17 delivered vaginally and nine underwent urgent cesarean delivery (35%, 95% CI 17-56%; seven nonreassuring fetal heart tracings and two breech). There were no cases of uterine rupture or dehiscence. Most (94%, 95% CI 80-99%) had normal 5-minute Apgar scores; one neonate (3%, 95% CI 0-15%) had acidosis but normal Apgar scores. Our data regarding trial of labor, use of low-dose oxytocin, and vaginal delivery after prenatal fetoscopic neural tube defect repair are

Relative importance of professional practice and engineering management competencies

Science.gov (United States)

Pons, Dirk

2016-09-01

Problem: The professional practice of engineering always involves engineering management, but it is difficult to know what specifically to include in the undergraduate curriculum. Approach: The population of New Zealand practising engineers was surveyed to determine the importance they placed on specific professional practice and engineering management competencies. Findings: Results show that communication and project planning were the two most important topics, followed by others as identified. The context in which practitioners use communication skills was found to be primarily with project management, with secondary contexts identified. The necessity for engineers to develop the ability to use multiple soft skills in an integrative manner is strongly supported by the data. Originality: This paper is one of only a few large-scale surveys of practising engineers to have explored the soft skill attributes. It makes a didactic contribution of providing a ranked list of topics which can be used for designing the curriculum and prioritising teaching effort, which has not previously been achieved. It yields the new insight that combinations of topics are sometimes more important than individual topics.

Bridge deterioration models to support Indiana's bridge management system.

Science.gov (United States)

2016-02-01

An effective bridge management system that is equipped with reliable deterioration models enables agency engineers to carry out : monitoring and long-term programming of bridge repair actions. At the project level, deterioration models help the agenc...

Journal of Modeling, Design and Management of Engineering ...

African Journals Online (AJOL)

Journal of Modeling, Design and Management of Engineering Systems. ... Journal Home > Vol 5, No 1 (2007) ... or mathematical modeling, computing, simulation, design and/or operations research tools for solving engineering problems.

Evolving technologies drive the new roles of Biomedical Engineering.

Science.gov (United States)

Frisch, P H; St Germain, J; Lui, W

2008-01-01

Rapidly changing technology coupled with the financial impact of organized health care, has required hospital Biomedical Engineering organizations to augment their traditional operational and business models to increase their role in developing enhanced clinical applications utilizing new and evolving technologies. The deployment of these technology based applications has required Biomedical Engineering organizations to re-organize to optimize the manner in which they provide and manage services. Memorial Sloan-Kettering Cancer Center has implemented a strategy to explore evolving technologies integrating them into enhanced clinical applications while optimally utilizing the expertise of the traditional Biomedical Engineering component (Clinical Engineering) to provide expanded support in technology / equipment management, device repair, preventive maintenance and integration with legacy clinical systems. Specifically, Biomedical Engineering is an integral component of the Medical Physics Department which provides comprehensive and integrated support to the Center in advanced physical, technical and engineering technology. This organizational structure emphasizes the integration and collaboration between a spectrum of technical expertise for clinical support and equipment management roles. The high cost of clinical equipment purchases coupled with the increasing cost of service has driven equipment management responsibilities to include significant business and financial aspects to provide a cost effective service model. This case study details the dynamics of these expanded roles, future initiatives and benefits for Biomedical Engineering and Memorial Sloan Kettering Cancer Center.

Endoscopic Endonasal Dacryocystorhinostomy Combined with Canaliculus Repair for the Management of Dacryocystitis with Canalicular Obstruction

Directory of Open Access Journals (Sweden)

Yunhai Tu

2015-01-01

Full Text Available Purpose. The aim of this study is to propose a simple and efficient combination surgery for the management of dacryocystitis with canalicular obstruction. Methods. A retrospective noncomparative case series of dacryocystitis with canalicular obstruction has been studied. Twelve patients with dacryocystitis and canalicular obstruction underwent a conventional endoscopic endonasal dacryocystorhinostomy (EE-DCR combined with a modified canalicular repair. Postoperative observations included slit lamp, fluorescein dye disappearance test, lacrimal syringing, lacrimal endoscopy, and nasal endoscopy. Results. After 6–18 months of postoperative follow-up, the symptoms of epiphora and mucopurulent discharge disappeared completely in 10 patients, and occasional or intermittent epiphora remained in 2 patients. All of the twelve patients showed an opened intranasal ostium and normal fluorescein dye disappearance test. Patent bicanalicular irrigation was achieved in 9 patients. One patient had a partial and the other two had a complete reobstruction by lacrimal irrigation to their repaired lower canaliculus; however, all of them had a patent lacrimal irrigation to upper canaliculus. The functional success rate for the combination surgery is 83% (10/12, and anatomical success rate is 75% (9/12. Conclusion. EE-DCR combined with modified canalicular repair is a simple and efficient method for the management of dacryocystitis with canalicular obstruction.

Optimum layout of engine thermal management; Optimale Auslegung des Motor-Thermomanagements

Energy Technology Data Exchange (ETDEWEB)

Beykirch, Ruediger; Knauf, Juergen; Lehmann, Joerg [FEV GmbH, Aachen (Germany). Simulation Ottomotoren; Beulshausen, Johannes [RWTH Aachen Univ. (Germany). Lehrstuhl fuer Verbrennungskraftmaschinen

2013-05-01

Optimising an engine's thermal management on the basis of different driving cycles and vehicle and engine tests is both time-consuming and costly. FEV GmbH, in cooperation with the Institute for Combustion Engines at RWTH Aachen University, has developed a holistic simulation model that enables the thermal management of an individual engine to be optimised.

Conversational Repair in School-Aged Children with High-Functioning Autism

Directory of Open Access Journals (Sweden)

Pei-Mei Lu

2015-12-01

Full Text Available The main purpose of this study was to investigate the conversational repair skills of Mandarin Chinese-speaking children with high-functioning autism (HFA as compared with those of typically developing children (TD. Ten school-aged children (age 9 to 12 with HFA were recruited and matched against ten TD children in the control group based on age, gender, and verbal intelligence level. During three different conversation situations (free talk, story picture description, play, an examiner engineered 9 episodes of communicative breakdowns. Each consisted of a stacked series of three prompts for responding to requests for clarification (RQCLs (i.e.‘What?’, ‘I don’t understand’, ‘I still don’t know’. Verbal responses to each RQCL were then coded for further analyses. The results showed that (1 In response to the stacked series RQCLs, children with HFA were similar to the control group children in evidencing repetition, revision, and addition types of repair. Furthermore, children with HFA showed fewer cue type of repair and more inappropriate type of repair than TD group. (2For both groups, the pattern of responding over the series of RQCLs was similar in varying the repetition and revision types of repair strategies. However, the pattern in the addition, cue, and inappropriate types of repair strategies were different. Children with HFA were significantly more likely to respond to an RQCL with an inappropriate response than the language and age-matched controls. It is suggested that teachers and parents could facilitate the conversational repair skills of children with high-functioning autism by offering them opportunities to manage different types of communicative breakdowns.

Gasoline engine management systems and components

CERN Document Server

2015-01-01

The call for environmentally compatible and economical vehicles necessitates immense efforts to develop innovative engine concepts. Technical concepts such as gasoline direct injection helped to save fuel up to 20 % and reduce CO2-emissions. Descriptions of the cylinder-charge control, fuel injection, ignition and catalytic emission-control systems provides comprehensive overview of today´s gasoline engines. This book also describes emission-control systems and explains the diagnostic systems. The publication provides information on engine-management-systems and emission-control regulations. Contents History of the automobile.- Basics of the gasoline engine.- Fuels.- Cylinder-charge control systems.- Gasoline injection systems over the years.- Fuel supply.- Manifold fuel injection.- Gasoline direct injection.- Operation of gasoline engines on natural gas.- Ignition systems over the years.- Inductive ignition systems.- Ignition coils.- Spark plugs.- Electronic control.- Sensors.- Electronic control unit.- Exh...

Repository-Based Software Engineering Program: Working Program Management Plan

Science.gov (United States)

1993-01-01

Repository-Based Software Engineering Program (RBSE) is a National Aeronautics and Space Administration (NASA) sponsored program dedicated to introducing and supporting common, effective approaches to software engineering practices. The process of conceiving, designing, building, and maintaining software systems by using existing software assets that are stored in a specialized operational reuse library or repository, accessible to system designers, is the foundation of the program. In addition to operating a software repository, RBSE promotes (1) software engineering technology transfer, (2) academic and instructional support of reuse programs, (3) the use of common software engineering standards and practices, (4) software reuse technology research, and (5) interoperability between reuse libraries. This Program Management Plan (PMP) is intended to communicate program goals and objectives, describe major work areas, and define a management report and control process. This process will assist the Program Manager, University of Houston at Clear Lake (UHCL) in tracking work progress and describing major program activities to NASA management. The goal of this PMP is to make managing the RBSE program a relatively easy process that improves the work of all team members. The PMP describes work areas addressed and work efforts being accomplished by the program; however, it is not intended as a complete description of the program. Its focus is on providing management tools and management processes for monitoring, evaluating, and administering the program; and it includes schedules for charting milestones and deliveries of program products. The PMP was developed by soliciting and obtaining guidance from appropriate program participants, analyzing program management guidance, and reviewing related program management documents.

Managing engineering to meet construction requirements

International Nuclear Information System (INIS)

Martin, D.F.; Houchen, J.D.

1976-01-01

The San Onofre Units 2 and 3 Project schedule is compared with Bechtel's Generic Nuclear Power Plant schedule. This comparison shows that the major delays experienced on the San Onofre Project have resulted from the regulatory process. To date, Engineering has met Construction's requirements and the Project has not experienced any Engineering related delays. The San Onofre Project has been faced with many uncertainties, such as limited site area, high seismic design criteria, new and changing Federal and State regulations, shifts in supplier market conditions and unpredictable supplier performance. Each of these uncertainties has impacted the Engineering effort and jeopardized project schedule goals. The SCE-Bechtel Engineering Management team has acted to mitigate the impact of these uncertainties through use of a cost trend program, simplification of SCE-Bechtel interfaces, close Engineering-Construction coordination, the use of task forces to handle critical supplier problems and the use of additional Engineering personnel, etc. so that Construction requirements have been met

MANAGING ENGINEERING ACTIVITIES FOR THE PLATEAU REMEDIATION CONTRACT - HANFORD

International Nuclear Information System (INIS)

Kronvall, C.M.

2011-01-01

In 2008, the primary Hanford clean-up contract transitioned to the CH2MHill Plateau Remediation Company (CHPRC). Prior to transition, Engineering resources assigned to remediation/Decontamination and Decommissioning (D and D) activities were a part of a centralized engineering organization and matrixed to the performing projects. Following transition, these resources were reassigned directly to the performing project, with a loose matrix through a smaller Central Engineering (CE) organization. The smaller (10 FTE) central organization has retained responsibility for the overall technical quality of engineering for the CHPRC, but no longer performs staffing and personnel functions. As the organization has matured, there are lessons learned that can be shared with other organizations going through or contemplating performing a similar change. Benefits that have been seen from the CHPRC CE organization structure include the following: (1) Staff are closely aligned with the 'Project/facility' that they are assigned to support; (2) Engineering priorities are managed to be consistent with the 'Project/facility' priorities; (3) Individual Engineering managers are accountable for identifying staffing needs and the filling of staffing positions; (4) Budget priorities are managed within the local organization structure; (5) Rather than being considered a 'functional' organization, engineering is considered a part of a line, direct funded organization; (6) The central engineering organization is able to provide 'overview' activities and maintain independence from the engineering organizations in the field; and (7) The central engineering organization is able to maintain a stable of specialized experts that are able to provide independent reviews of field projects and day-to-day activities.

Security Requirements Management in Software Product Line Engineering

Science.gov (United States)

Mellado, Daniel; Fernández-Medina, Eduardo; Piattini, Mario

Security requirements engineering is both a central task and a critical success factor in product line development due to the complexity and extensive nature of product lines. However, most of the current product line practices in requirements engineering do not adequately address security requirements engineering. Therefore, in this chapter we will propose a security requirements engineering process (SREPPLine) driven by security standards and based on a security requirements decision model along with a security variability model to manage the variability of the artefacts related to security requirements. The aim of this approach is to deal with security requirements from the early stages of the product line development in a systematic way, in order to facilitate conformance with the most relevant security standards with regard to the management of security requirements, such as ISO/IEC 27001 and ISO/IEC 15408.

A NEW Curriclum for Manufacturing & Industrial Engineering and Engineering Management for Bs and Ms Degrees

OpenAIRE

SARI, Zaki

2012-01-01

This paper deals with the design and implementation of a new curriclum for manufacturing & industrial engineering and engineering management for bachelor and master degrees at tlemcen university, algeria

Evolution of hospital industrial engineering: from scientific management to total quality management.

Science.gov (United States)

Sahney, V K

1993-01-01

Industrial engineering applications in the hospital industry first began in 1910. This paper traces the evolution of hospital industrial engineering in five distinct phases. For each of the major phases, this paper presents the contributions made by industrial engineers. Many of the techniques advocated by industrial engineers are now being taught to hospital employees as hospitals introduce total quality management (TQM) within the health-care industry. TQM introduction has meant a new role for industrial engineers, as that of a teacher, coach, and a facilitator. This new role holds much promise for the improvement of quality and productivity in health care.

LEARNING MANAGEMENT SYSTEMS: ENGINEERING THE EDUCATION INDUSTRY TO EDUCATE THE INDUSTRIAL ENGINEER

Directory of Open Access Journals (Sweden)

L. Van Dyk

2012-01-01

Full Text Available

ENGLISH ABSTRACT: A learning management system (LMS is any infrastructure on which e-learning can be built and delivered. In this article two sides of the LMS coin are investigated: On the one side, it is argued that industrial and systems engineering skills are equally relevant for learning systems as for as for any other system. To support this argument, an analogy is drawn between the management of learning systems and the management of manufacturing systems. On the other side of the coin, the educational issues and concerns related to implementing an LMS at the University of Pretoria are investigated by means of a case study in the Industrial Engineering department. It is concluded that the industrial engineering educator is in the unique position of understanding and contributing towards the engineering of the education industry whilst educating the industrial engineer.

AFRIKAANSE OPSOMMING: ‘n Leerbestuurstelsel (LMS is enige infrastruktuur waarop e-leer gebou en afgelewer kan word. In hierdie artikel word beide kante van die LMS muntstuk ondersoek: Aan die een kant word getoon dat bedryfsingenieursvaardighede en -beginsels ewe toepaslik is op leerstelsels as op vervaardigingstelsels. Om hierdie argument te steun word 'n analogie getrek tussen the bestuur van leerstelsels en die bestuur van vervaardigingstelsels. Aan die ander kant van die muntstuk word die opvoedkundige aspekte verbonde aan die implementering van ‘n leerbestuurstelsel (LMS aan die Universiteit van Pretoria ondersoek aan die hand van ‘n gevallestudie in die Bedryfsingenieursdepartment. Die gevolgtrekking word gemaak dat die bedryfsingenieurs-opleier in 'n unieke posisie is om die opleidingsindustrie te begryp en by dra tot the ontwikkeling daarvan terwyl die bedryfsingenieur opgelei word.

21st International Conference on Industrial Engineering and Engineering Management

CERN Document Server

Shen, Jiang; Dou, Runliang

2015-01-01

Being the premier forum for the presentation of new advances and research results in the fields of Industrial Engineering, IEEM 2014 aims to provide a high-level international forum for experts, scholars and entrepreneurs at home and abroad to present the recent advances, new techniques and applications face and face, to promote discussion and interaction among academics, researchers and professionals to promote the developments and applications of the related theories and technologies in universities and enterprises and to establish business or research relations to find global partners for future collaboration in the field of Industrial Engineering. All the goals of the international conference are to fulfill the mission of the series conference which is to review, exchange, summarize and promote the latest achievements in the field of industrial engineering and engineering management over the past year and to propose prospects and vision for the further development.

Reusable Rocket Engine Advanced Health Management System. Architecture and Technology Evaluation: Summary

Science.gov (United States)

Pettit, C. D.; Barkhoudarian, S.; Daumann, A. G., Jr.; Provan, G. M.; ElFattah, Y. M.; Glover, D. E.

1999-01-01

In this study, we proposed an Advanced Health Management System (AHMS) functional architecture and conducted a technology assessment for liquid propellant rocket engine lifecycle health management. The purpose of the AHMS is to improve reusable rocket engine safety and to reduce between-flight maintenance. During the study, past and current reusable rocket engine health management-related projects were reviewed, data structures and health management processes of current rocket engine programs were assessed, and in-depth interviews with rocket engine lifecycle and system experts were conducted. A generic AHMS functional architecture, with primary focus on real-time health monitoring, was developed. Fourteen categories of technology tasks and development needs for implementation of the AHMS were identified, based on the functional architecture and our assessment of current rocket engine programs. Five key technology areas were recommended for immediate development, which (1) would provide immediate benefits to current engine programs, and (2) could be implemented with minimal impact on the current Space Shuttle Main Engine (SSME) and Reusable Launch Vehicle (RLV) engine controllers.

Configuration management program plan for Hanford site systems engineering

International Nuclear Information System (INIS)

Hoffman, A.G.

1994-01-01

This plan establishes the integrated configuration management program for the evolving technical baseline developed through the systems engineering process. This configuration management program aligns with the criteria identified in the DOE Standard, DOE-STD-1073-93. Included are specific requirements for control of the systems engineering RDD-100 database, and electronic data incorporated in the database that establishes the Hanford site technical baseline

MANAGING ENGINEERING ACTIVITIES FOR THE PLATEAU REMEDIATION CONTRACT - HANFORD

Energy Technology Data Exchange (ETDEWEB)

KRONVALL CM

2011-01-14

In 2008, the primary Hanford clean-up contract transitioned to the CH2MHill Plateau Remediation Company (CHPRC). Prior to transition, Engineering resources assigned to remediation/Decontamination and Decommissioning (D&D) activities were a part of a centralized engineering organization and matrixed to the performing projects. Following transition, these resources were reassigned directly to the performing project, with a loose matrix through a smaller Central Engineering (CE) organization. The smaller (10 FTE) central organization has retained responsibility for the overall technical quality of engineering for the CHPRC, but no longer performs staffing and personnel functions. As the organization has matured, there are lessons learned that can be shared with other organizations going through or contemplating performing a similar change. Benefits that have been seen from the CHPRC CE organization structure include the following: (1) Staff are closely aligned with the 'Project/facility' that they are assigned to support; (2) Engineering priorities are managed to be consistent with the 'Project/facility' priorities; (3) Individual Engineering managers are accountable for identifying staffing needs and the filling of staffing positions; (4) Budget priorities are managed within the local organization structure; (5) Rather than being considered a 'functional' organization, engineering is considered a part of a line, direct funded organization; (6) The central engineering organization is able to provide 'overview' activities and maintain independence from the engineering organizations in the field; and (7) The central engineering organization is able to maintain a stable of specialized experts that are able to provide independent reviews of field projects and day-to-day activities.

46 CFR 2.20-40 - Chief engineer's reports.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Chief engineer's reports. 2.20-40 Section 2.20-40... INSPECTIONS Reports and Forms § 2.20-40 Chief engineer's reports. (a) Repairs to boilers and pressure vessels. The chief engineer is required to report any repairs to boilers or unfired pressure vessels in...

A Case Study: Data Management in Biomedical Engineering

Directory of Open Access Journals (Sweden)

Glenn R. Gaudette

2012-01-01

Full Text Available In a biomedical engineering lab at Worcester Polytechnic Institute, co-author Dr. Glenn R. Gaudette and his research team are investigating the effects of stem cell therapy on the regeneration of function in damaged cardiac tissue in laboratory rats. Each instance of stem cell experimentation on a rat yields hundreds of data sets that must be carefully captured, documented and securely stored so that the data will be easily accessed and retrieved for papers, reports, further research, and validation of findings, while meeting NIH guidelines for data sharing. After a brief introduction to the bioengineering field and stem cell research, this paper focuses on the experimental workflow and the data generated in one instance of stem cell experimentation; the lab’s data management practices; and how Dr. Gaudette teaches data management to the lab’s incoming graduate students each semester. The co-authors discuss the haphazard manner by which engineering and science students typically learn data management practices, and advocate for the integration of formal data management instruction in higher education STEM curricula. The paper concludes with a discussion of the Frameworks for a Data Management Curriculum developed collaboratively by the co-authors’ institutions -- the University of Massachusetts Medical School and Worcester Polytechnic Institute -- to teach data management best practices to students in the sciences, health sciences, and engineering.

Team Management of a Young Adult with a Traumatic Cleft Repair

Directory of Open Access Journals (Sweden)

Nandini V Kamat

2011-01-01

This case report describes management of an adult patient with a traumatically repaired cleft. The maxilla was deficient in all three planes and the mandible appeared protrusive. The patient′s speech had nasalance and articulation problems. The patient was informed about the possibility of speech deterioration post-surgery and was explained about the options available. After appropriate presurgical orthodontics, maxilla was surgically expanded and was also advanced by 5 mm. After surgery, speech was more intelligible because of improved articulation. It was possible to get optimum esthetic and functional result due to coordinated team approach.

Relative Importance of Professional Practice and Engineering Management Competencies

Science.gov (United States)

Pons, Dirk

2016-01-01

Problem: The professional practice of engineering always involves engineering management, but it is difficult to know what specifically to include in the undergraduate curriculum. Approach: The population of New Zealand practising engineers was surveyed to determine the importance they placed on specific professional practice and engineering…

Characterisation, control, and energy management of electrified turbocharged diesel engines

International Nuclear Information System (INIS)

Zhao, Dezong; Winward, Edward; Yang, Zhijia; Stobart, Richard; Steffen, Thomas

2017-01-01

Highlights: • A real-time energy management framework for electrified engines is proposed. • A multi-variable robust controller is designed. • Characterisation on the air system of electrified diesel engines is given. • Reliable for engine downsizing because of the promising transient performance. - Abstract: The electrification of engine components offers significant opportunities for fuel efficiency improvements. The electrified turbocharger is one of the most attractive options since it recovers part of the engine exhaust gas mechanical energy to assist boosting. Therefore, the engine can be downsized through improved transient responsiveness. In the electrified turbocharger, an electric machine is mounted on the turbine shaft and changes the air system dynamics, so characterisation of the new layout is essential. A systematic control solution is required to manage energy flows in the hybrid system. In this paper, a framework for characterisation, control, and energy management for an electrified turbocharged diesel engine is proposed. The impacts of the electric machine on fuel economy and air system variables are analysed. Based on the characterisation, a two-level control structure is proposed. A real-time energy management strategy is employed as the supervisory level controller to generate the optimal values of critical variables, while a model-based multi-variable controller is designed as the low level controller to track the values. The two controllers work together in a cascade to address both fuel economy optimisation and battery state-of-charge maintenance. The proposed control strategy is validated on a high fidelity physical engine model. The tracking performance shows the proposed framework is a promising solution in regulating the behavior of electrified engines.

Managing the three-rivers headwater region, china: from ecological engineering to social engineering.

Science.gov (United States)

Fang, Yiping

2013-09-01

The three-rivers headwater region (THRHR) of Qinghai province, China plays a key role as source of fresh water and ecosystem services for central and eastern China. Global warming and human activities in the THRHR have threatened the ecosystem since the 1980s. Therefore, the Chinese government has included managing of the THRHR in the national strategy since 2003. The State Integrated Test and Demonstration Region of the THRHR highlights the connection with social engineering (focus on improving people's livelihood and well-being) in managing nature reserves. Based on this program, this perspective attempts a holistic analysis of the strategic role of the THRHR, requirements for change, indices of change, and approaches to change. Long-term success of managing nature reserves requires effective combination of ecological conservation, economic development, and social progress. Thus, the philosophy of social engineering should be employed as a strategy to manage the THRHR.

Intensive Care Management of Thoracic Aortic Surgical Patients, Including Thoracic and Infradiaphragmatic Endovascular Repair (EVAR/TEVAR).

Science.gov (United States)

Cole, Sheela Pai

2015-12-01

The patient with thoracic aortic disease can present for open or endovascular repair. Thoracic endovascular aortic repair (TEVAR) has emerged as a minimally invasive option for a multitude of aortic pathology, including dissections, aneurysms, traumatic injuries, and ulcers. Postoperative management of these patients depends on the extent of procedure, whether it was open or endovascular, and, finally, on the preoperative comorbidities present. While procedural success has catapulted TEVAR to popularity, midterm results have been mixed. Additionally, periprocedural complications such as paraplegia and renal failure remain a significant morbidity in these patients. © The Author(s) 2015.

Tissue-Engineered Tendon for Enthesis Regeneration in a Rat Rotator Cuff Model

Directory of Open Access Journals (Sweden)

Michael J. Smietana

2017-06-01

Full Text Available Healing of rotator cuff (RC injuries with current suture or augmented scaffold techniques fails to regenerate the enthesis and instead forms a weaker fibrovascular scar that is prone to subsequent failure. Regeneration of the enthesis is the key to improving clinical outcomes for RC injuries. We hypothesized that the utilization of our tissue-engineered tendon to repair either an acute or a chronic full-thickness supraspinatus tear would regenerate a functional enthesis and return the biomechanics of the tendon back to that found in native tissue. Engineered tendons were fabricated from bone marrow-derived mesenchymal stem cells utilizing our well-described fabrication technology. Forty-three rats underwent unilateral detachment of the supraspinatus tendon followed by acute (immediate or chronic (4 weeks retracted repair by using either our engineered tendon or a trans-osseous suture technique. Animals were sacrificed at 8 weeks. Biomechanical and histological analyses of the regenerated enthesis and tendon were performed. Statistical analysis was performed by using a one-way analysis of variance with significance set at p < 0.05. Acute repairs using engineered tendon had improved enthesis structure and lower biomechanical failures compared with suture repairs. Chronic repairs with engineered tendon had a more native-like enthesis with increased fibrocartilage formation, reduced scar formation, and lower biomechanical failure compared with suture repair. Thus, the utilization of our tissue-engineered tendon showed improve enthesis regeneration and improved function in chronic RC repairs compared with suture repair. Clinical Significance: Our engineered tendon construct shows promise as a clinically relevant method for repair of RC injuries.

Integrated Management System Incorporating Quality Management and Management of Environment, Health and Occupational Safety

International Nuclear Information System (INIS)

Manchev, B.; Nenkova, B.; Tomov, E.

2012-01-01

Risk Engineering Ltd is a Bulgarian private company founded in 1990 to provide engineering and consulting services applicable to each and every field of the energy sector. Since its establishment Risk Engineering Ltd develops, implement and apply a System for quality assurance, certified for the first time by BVQI (now Bureau Veritas Certification) in 1999 for conformity with the standard ISO 9001:1994. Later on, in connection with the revision of the standards of ISO 9000 series and introduction of the standard ISO 9001:2000 a Quality Management System in conformity with the standard ISO 9001:2000 was developed, introduced and certified. At present, Risk Engineering Ltd has got developed, documented, introduced and certified by Lloyd's Register Quality Assurance (LRQA) Quality Management System in compliance with ISO 9001:2008 on the process approach basis. On this basis and including the requirements of the ISO 14001:2004 (regarding the environment) and OHSAS 18001:2007 (regarding the health and occupational safety), Risk Engineering Ltd has developed and introduced Integrated Management System aim at achieving and demonstrating good results regarding protection of the environment, health and occupational safety. The processes under control by the Integrated Management System and applicable at the company are divided in two general types: A) Management processes: Strategic management and Management of the human resources. B) Processes describing the main activities: design/development process; project management; management of industrial projects and technical infrastructure project; construction, installation, repair and operation of power industry facilities; commercial activities and marketing; investigation of energy efficiency of industrial systems and certification of buildings regarding energy efficiency; consulting activity in the field of industry and energy as well as consultant in accordance with the Law of the Spatial Planning; management of the

Engineering solutions to the management of solid radioactive waste

International Nuclear Information System (INIS)

1991-01-01

The management of radioactive waste, its safe handling and ultimate disposal, is of vital concern to engineers in the nuclear industry. The international conference 'Engineering Solutions to the Management of Solid Radioactive Waste', organized by the Institution of Mechanical Engineers and held in Manchester in November 1991, provided a forum for the discussion and comparison of the different methods of waste management used in Europe and America. Papers presented and discussed included: the interaction between the design of containers for low level radioactive waste and the design of a deep repository, commercial low level waste disposal sites in the United States, and the development of radioactive waste monitoring systems at the Sellafield reprocessing complex. This volume is a collection of 22 papers presented at the conference. All are indexed separately. (author)

Promoting peripheral myelin repair.

Science.gov (United States)

Zhou, Ye; Notterpek, Lucia

2016-09-01

Compared to the central nervous system (CNS), peripheral nerves have a remarkable ability to regenerate and remyelinate. This regenerative capacity to a large extent is dependent on and supported by Schwann cells, the myelin-forming glial cells of the peripheral nervous system (PNS). In a variety of paradigms, Schwann cells are critical in the removal of the degenerated tissue, which is followed by remyelination of newly-regenerated axons. This unique plasticity of Schwann cells has been the target of myelin repair strategies in acute injuries and chronic diseases, such as hereditary demyelinating neuropathies. In one approach, the endogenous regenerative capacity of Schwann cells is enhanced through interventions such as exercise, electrical stimulation or pharmacological means. Alternatively, Schwann cells derived from healthy nerves, or engineered from different tissue sources have been transplanted into the PNS to support remyelination. These transplant approaches can then be further enhanced by exercise and/or electrical stimulation, as well as by the inclusion of biomaterial engineered to support glial cell viability and neurite extension. Advances in our basic understanding of peripheral nerve biology, as well as biomaterial engineering, will further improve the functional repair of myelinated peripheral nerves. Copyright © 2016 Elsevier Inc. All rights reserved.

Engineering data management in vogelvlucht : realiteit of toekomstmuziek?

NARCIS (Netherlands)

Breuls, P.M.A.M.

1994-01-01

In dit artikel zal het onderwerp ‘Engineering Data Management’ in vogelvlucht besproken worden. Dit houdt in dat achtereenvolgens, met een beperkte mate van detaillering, ingegaan zal worden op: wat is Engineering Data Management nu eigenlijk en waarom is het een actueel thema? Vervolgens worden de

3rd International Conference on Modelling and Management of Engineering Processes

CERN Document Server

Gericke, Kilian; Szélig, Nikoletta; Vajna, Sándor

2015-01-01

Innovative processes for the development of products and services are more and more considered as an organisational capability, which is recognised to be increasingly important for business success in today’s competitive environment. However, management and academia need a more profound understanding of these processes in order to develop improved management approaches to exploit business potentials. This book contains the proceedings of the 3rd International Conference on Modelling and Management of Engineering Processes (MMEP2013) held in Magdeburg, Germany, in November 2013. It includes contributions from international leading researchers in the fields of process modelling and process management. The conference topics were recent trends in modelling and management of engineering processes, potential synergies between different modelling approaches, future challenges for the management of engineering processes as well as future research in these areas.

Tissue-engineered rhesus monkey nerve grafts for the repair of long ulnar nerve defects: similar outcomes to autologous nerve grafts

Directory of Open Access Journals (Sweden)

Chang-qing Jiang

2016-01-01

Full Text Available Acellular nerve allografts can help preserve normal nerve structure and extracellular matrix composition. These allografts have low immunogenicity and are more readily available than autologous nerves for the repair of long-segment peripheral nerve defects. In this study, we repaired a 40-mm ulnar nerve defect in rhesus monkeys with tissue-engineered peripheral nerve, and compared the outcome with that of autograft. The graft was prepared using a chemical extract from adult rhesus monkeys and seeded with allogeneic Schwann cells. Pathomorphology, electromyogram and immunohistochemistry findings revealed the absence of palmar erosion or ulcers, and that the morphology and elasticity of the hypothenar eminence were normal 5 months postoperatively. There were no significant differences in the mean peak compound muscle action potential, the mean nerve conduction velocity, or the number of neurofilaments between the experimental and control groups. However, outcome was significantly better in the experimental group than in the blank group. These findings suggest that chemically extracted allogeneic nerve seeded with autologous Schwann cells can repair 40-mm ulnar nerve defects in the rhesus monkey. The outcomes are similar to those obtained with autologous nerve graft.

Tissue-engineered rhesus monkey nerve gratfs for the repair of long ulnar nerve defects：similar outcomes to autologous nerve gratfs

Institute of Scientific and Technical Information of China (English)

Chang-qing Jiang; Jun Hu; Jian-ping Xiang; Jia-kai Zhu; Xiao-lin Liu; Peng Luo

2016-01-01

Acellular nerve allogratfs can help preserve normal nerve structure and extracellular matrix composition. These allogratfs have low immu-nogenicity and are more readily available than autologous nerves for the repair of long-segment peripheral nerve defects. In this study, we repaired a 40-mm ulnar nerve defect in rhesus monkeys with tissue-engineered peripheral nerve, and compared the outcome with that of autogratf. The gratf was prepared using a chemical extract from adult rhesus monkeys and seeded with allogeneic Schwann cells. Pathomo-rphology, electromyogram and immunohistochemistry ifndings revealed the absence of palmar erosion or ulcers, and that the morphology and elasticity of the hypothenar eminence were normal 5 months postoperatively. There were no signiifcant differences in the mean peak compound muscle action potential, the mean nerve conduction velocity, or the number of neuroiflaments between the experimental and control groups. However, outcome was signiifcantly better in the experimental group than in the blank group. These ifndings suggest that chemically extracted allogeneic nerve seeded with autologous Schwann cells can repair 40-mm ulnar nerve defects in the rhesus monkey. The outcomes are similar to those obtained with autologous nerve gratf.

Virtual engine management simulator for educational purposes

Science.gov (United States)

Drosescu, R.

2017-10-01

This simulator was conceived as a software program capable of generating complex control signals, identical to those in the electronic management systems of modern spark ignition or diesel engines. Speed in rpm and engine load percentage defined by throttle opening angle represent the input variables in the simulation program and are graphically entered by two-meter instruments from the simulator central block diagram. The output signals are divided into four categories: synchronization and position of each cylinder, spark pulses for spark ignition engines, injection pulses and, signals for generating the knock window for each cylinder in the case of a spark ignition engine. The simulation program runs in real-time so each signal evolution reflects the real behavior on a physically thermal engine. In this way, the generated signals (ignition or injection pulses) can be used with additionally drivers to control an engine on the test bench.

8th World Congress on Engineering Asset Management & the 3rd International Conference on Utility Management & Safety

CERN Document Server

Mathew, Joseph; Wong, King; Lam, Rocky; Ko, CN; WCEAM 2013; ICUMAS; Engineering asset management : systems, professional practices and certification

2015-01-01

This proceedings represents state-of-the-art trends and developments in the emerging field of engineering asset management as presented at the Eight World Congress on Engineering Asset Management (WCEAM). The Proceedings of the WCEAM 2013 is an excellent reference for practitioners, researchers and students in the multidisciplinary field of asset management, covering topics such as: Asset condition monitoring and intelligent maintenance, 2.  Asset data warehousing, data mining and fusion, 3. Asset performance and level-of-service models, 4. Design and life-cycle integrity of physical assets, 5. Deterioration and preservation models for assets, 6. Education and training in asset management, 7. Engineering standards in asset management, 8. Fault diagnosis and prognostics, 9. Financial analysis methods for physical assets, 10. Human dimensions in integrated asset management, 11. Information quality management, 12. Information systems and knowledge management, 13. Intelligent sensors and devices, 14. Maintenance...

Tools and Methods for Risk Management in Multi-Site Engineering Projects

Science.gov (United States)

Zhou, Mingwei; Nemes, Laszlo; Reidsema, Carl; Ahmed, Ammar; Kayis, Berman

In today's highly global business environment, engineering and manufacturing projects often involve two or more geographically dispersed units or departments, research centers or companies. This paper attempts to identify the requirements for risk management in a multi-site engineering project environment, and presents a review of the state-of-the-art tools and methods that can be used to manage risks in multi-site engineering projects. This leads to the development of a risk management roadmap, which will underpin the design and implementation of an intelligent risk mapping system.

Learning Objectives for Master's theses at DTU Management Engineering

DEFF Research Database (Denmark)

Hansen, Claus Thorp; Rasmussen, Birgitte; Hinz, Hector Nøhr

2010-01-01

, different. The DTU Study Handbook states that:”Learning objectives are an integrated part of the supervision”, which provides you with the opportunity – naturally in cooperation with your supervisor – to formulate learning objectives for your Master's thesis. There are at least three good reasons for being...... that you formulate precise and useful learning objectives for your Master's thesis. These notes of inspiration have been written to help you do exactly this. The notes discuss the requirements for the learning objectives, examples of learning objectives and the assessment criteria defined by DTU Management...... Engineering as well as, but not least, some useful things to remember concerning your submission and the assessment of the Master's thesis. DTU Management Engineering Claus Thorp Hansen Birgitte Rasmussen Hector Nøhr Hinz © DTU Management Engineering 2010 ISBN nr. 978-87-90855-94-7 This document...

A search engine for the engineering and equipment data management system (EDMS) at CERN

International Nuclear Information System (INIS)

Tsyganov, A; Amerigo, S M; Petit, S; Pettersson, T; Suwalska, A

2008-01-01

CERN, the European Laboratory for Particle Physics, located in Geneva -Switzerland, is currently building the LHC (Large Hadron Collider), a 27 km particle accelerator. The equipment life-cycle management of this project is provided by the Engineering and Equipment Data Management System (EDMS) Service. Using an Oracle database, it supports the management and follow-up of different kinds of documentation through the whole life cycle of the LHC project: design, manufacturing, installation, commissioning data etc... The equipment data collection phase is now slowing down and the project is getting closer to the 'As-Built' phase: the phase of the project consuming and exploring the large volumes of data stored since 1996. Searching through millions of items of information (documents, equipment parts, operations...) multiplied by dozens of points of view (operators, maintainers...) requires an efficient and flexible search engine. This paper describes the process followed by the team to implement the search engine for the LHC As-built project in the EDMS Service. The emphasis is put on the design decision to decouple the search engine from any user interface, potentially enabling other systems to also use it. Projections, algorithms, and the planned implementation are described in this paper. The implementation of the first version started in early 2007

Spinal Cord Repair with Engineered Nervous Tissue

Science.gov (United States)

2014-04-01

ganglia ( DRG ) and axons that can be stretch-grown to a length necessary to bridge extensive lesions. In current studies, we have optimized in vivo...survival of DRGs up to 6 weeks post-transplant. If successful, this approach will provide an alternative or additional means to repair large spinal...lesions. 15. SUBJECT TERMS- none listed 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF

Safety risk management of underground engineering in China: Progress, challenges and strategies

Directory of Open Access Journals (Sweden)

Qihu Qian

2016-08-01

Full Text Available Underground construction in China is featured by large scale, high speed, long construction period, complex operation and frustrating situations regarding project safety. Various accidents have been reported from time to time, resulting in serious social impact and huge economic loss. This paper presents the main progress in the safety risk management of underground engineering in China over the last decade, i.e. (1 establishment of laws and regulations for safety risk management of underground engineering, (2 implementation of the safety risk management plan, (3 establishment of decision support system for risk management and early-warning based on information technology, and (4 strengthening the study on safety risk management, prediction and prevention. Based on the analysis of the typical accidents in China in the last decade, the new challenges in the safety risk management for underground engineering are identified as follows: (1 control of unsafe human behaviors; (2 technological innovation in safety risk management; and (3 design of safety risk management regulations. Finally, the strategies for safety risk management of underground engineering in China are proposed in six aspects, i.e. the safety risk management system and policy, law, administration, economy, education and technology.

The influence of management and construction methods in the repair costs of Spain’s low-volume road network

Directory of Open Access Journals (Sweden)

Eutiquio Gallego

2016-06-01

Full Text Available This paper describes the entire process of the implementation of the Spanish low volume road network, including the design criteria, the construction techniques and the management policies during all the periods. The current situation of low volume roads in Spain was analyzed with respect to the legal framework and their actual condition. In addition, the budget required for the repair of 41 low volume roads throughout Spain was calculated in order to statistically analyze the influence of the pavement materials and the period of construction. The main conclusions were that low volume roads constructed during the 1970´s are currently those in the best state of repair and those requiring the lower repair costs, even lower than those constructed after 1980´s. In addition, low volume roads constructed with higher quality materials and using standardized techniques required five times lower repair costs than those made of lower quality materials.

Development of Management Methodology for Engineering Production Quality

Science.gov (United States)

Gorlenko, O.; Miroshnikov, V.; Borbatc, N.

2016-04-01

The authors of the paper propose four directions of the methodology developing the quality management of engineering products that implement the requirements of new international standard ISO 9001:2015: the analysis of arrangement context taking into account stakeholders, the use of risk management, management of in-house knowledge, assessment of the enterprise activity according to the criteria of effectiveness

Turbine repair process, repaired coating, and repaired turbine component

Science.gov (United States)

Das, Rupak; Delvaux, John McConnell; Garcia-Crespo, Andres Jose

2015-11-03

A turbine repair process, a repaired coating, and a repaired turbine component are disclosed. The turbine repair process includes providing a turbine component having a higher-pressure region and a lower-pressure region, introducing particles into the higher-pressure region, and at least partially repairing an opening between the higher-pressure region and the lower-pressure region with at least one of the particles to form a repaired turbine component. The repaired coating includes a silicon material, a ceramic matrix composite material, and a repaired region having the silicon material deposited on and surrounded by the ceramic matrix composite material. The repaired turbine component a ceramic matrix composite layer and a repaired region having silicon material deposited on and surrounded by the ceramic matrix composite material.

MANAGEMENT PROGRAMS ROAD REPAIR WORKS OF THE ROADS NETWORK

Directory of Open Access Journals (Sweden)

Вікторія Василівна ІГНАТЮК

2015-05-01

Full Text Available The paper discusses the model and algorithm optimization program of road repair works, with limited funds. Features introduction program for calculating rational level detection repair costs for the period of the program, which allows dos evolve a desired operating condition of the pavement.

Managing asset protection in the re-engineered environment of the nineties

International Nuclear Information System (INIS)

Bender, J.E.

1995-01-01

This paper discusses innovative management of equipment assets during this climate of increased competitiveness in order to reduce the costs of equipment failures, and avoid business interruptions and consequential loss of market share. The topics of the paper include proper design and specification, monitoring, maintenance, timely repair, and protecting buildings

Project No. 7 - Decommissioning unit at Ignalina NPP. (Engineering and project management)

International Nuclear Information System (INIS)

2000-01-01

In order to manage decommissioning process at Ignalina NPP, a new unit should be established in the framework of the Ignalina NPP organizational structure. The on-site Engineering Project Management Unit (PMU) will adopt an integrated approach to project management , engineering design, planning, procurement, safety and licensing activities at Ignalina NPP site. The PMU will assist the Ignalina NPP management in the development of an integrated decommissioning and waste management strategy

Primary repair of colon injuries: clinical study of nonselective approach.

Science.gov (United States)

Lazovic, Ranko G; Barisic, Goran I; Krivokapic, Zoran V

2010-12-02

This study was designed to determine the role of primary repair and to investigate the possibility of expanding indications for primary repair of colon injuries using nonselective approach. Two groups of patients were analyzed. Retrospective (RS) group included 30 patients managed by primary repair or two stage surgical procedure according to criteria published by Stone (S/F) and Flint (Fl). In this group 18 patients were managed by primary repair. Prospective (PR) group included 33 patients with primary repair as a first choice procedure. In this group, primary repair was performed in 30 cases. Groups were comparable regarding age, sex, and indexes of trauma severity. Time between injury and surgery was shorter in PR group, (1.3 vs. 3.1 hours). Stab wounds were more frequent in PR group (9:2), and iatrogenic lesions in RS group (6:2). Associated injuries were similar, as well as segmental distribution of colon injuries. S/F criteria and Flint grading were similar.In RS group 15 primary repairs were successful, while in two cases relaparotomy and colostomy was performed due to anastomotic leakage. One patient died. In PR group, 25 primary repairs were successful, with 2 immediate and 3 postoperative (7-10 days) deaths, with no evidence of anastomotic leakage. Results of this study justify more liberal use of primary repair in early management of colon injuries. Current Controlled Trials ISRCTN94682396.

NeuroManager: A workflow analysis based simulation management engine for computational neuroscience

Directory of Open Access Journals (Sweden)

David Bruce Stockton

2015-10-01

Full Text Available We developed NeuroManager, an object-oriented simulation management software engine for computational neuroscience. NeuroManager automates the workflow of simulation job submissions when using heterogeneous computational resources, simulators, and simulation tasks. The object-oriented approach 1 provides flexibility to adapt to a variety of neuroscience simulators, 2 simplifies the use of heterogeneous computational resources, from desktops to super computer clusters, and 3 improves tracking of simulator/simulation evolution. We implemented NeuroManager in Matlab, a widely used engineering and scientific language, for its signal and image processing tools, prevalence in electrophysiology analysis, and increasing use in college Biology education. To design and develop NeuroManager we analyzed the workflow of simulation submission for a variety of simulators, operating systems, and computational resources, including the handling of input parameters, data, models, results, and analyses. This resulted in twenty-two stages of simulation submission workflow. The software incorporates progress notification, automatic organization, labeling, and time-stamping of data and results, and integrated access to Matlab's analysis and visualization tools. NeuroManager provides users with the tools to automate daily tasks, and assists principal investigators in tracking and recreating the evolution of research projects performed by multiple people. Overall, NeuroManager provides the infrastructure needed to improve workflow, manage multiple simultaneous simulations, and maintain provenance of the potentially large amounts of data produced during the course of a research project.

22nd International Conference on Industrial Engineering and Engineering Management 2015

CERN Document Server

Shen, Jiang; Dou, Runliang; IEEM 2015; v.1 Core Theory and Applications of Industrial Engineering; v.2 Innovation and Practice in Industrial Engineering and Management

2016-01-01

Being the premier forum for the presentation of new advances and research results in the fields of Industrial Engineering, IEEM 2015 aims to provide a high-level international forum for experts, scholars and entrepreneurs at home and abroad to present the recent advances, new techniques and applications face and face, to promote discussion and interaction among academics, researchers and professionals to promote the developments and applications of the related theories and technologies in universities and enterprises, and to establish business or research relations to find global partners for future collaboration in the field of Industrial Engineering. All the goals of the international conference are to fulfill the mission of the series conference which is to review, exchange, summarize and promote the latest achievements in the field of industrial engineering and engineering management over the past year, and to propose prospects and vision for the further development. This volume is the first of the two pr...

General Mechanical Repair 2. Minor Automotive Maintenance, Small Engine [Repair, and] Welding. Curriculum Guide.

Science.gov (United States)

Hamlin, Larry

This curriculum guide provides materials for teachers to use in developing a 1-year course in general mechanical repair as part of the trade and industrial education curriculum. The guide contains the following: (1) essential elements common to all trade and industrial courses; (2) an instructional delivery outline (teaching sequence) for the…

18.2.3 Current Concepts on Tissue Engineering for Meniscus Repair

OpenAIRE

Mandelbaum, B.; Roos, H.; Shive, M.S.; Hambly, K.; Mithoefer, K.; Della Villa, S.; Silvers, H.J.; Hambly, K.; Fontana, A.; Dalemans, W.; Celis, P.; Brittberg, M.; Marcacci, M.; Kon, E.; Delcogliano, M.

2009-01-01

Introduction Articular cartilage lesions are a common pathology of the knee joint and many patients could benefit from cartilage repair. Untreated, however, cartilage defects may lead to osteoarthritis (OA). Thus, surgical treatment options may offer a possibility for patients with cartilage defects to avoid OA or to delay the progression of OA. Therefore, cartilage repair techniques require sophisticated follow-up, if possible non-invasively. Although clinical findings are the primary criter...

Switchgear project meticulously managed.

Science.gov (United States)

Baillie, Jonathan

2015-04-01

Electrical engineering and estates personnel at Sodexo--which manages a wide range of soft and hard facilities management services for five hospitals under a PFI contract at the Manchester Royal Infirmary--have successfully planned, managed, and co-ordinated, a complex electrical engineering project which saw high voltage (HV) switchgear in the site's main intake sub-station dismantled by the supplier to repair a potential earthing mechanism fault which would have prevented individual switchgear panels being shut down, to, for example, cater for renovation of electrical cabling or components cross the site's high voltage network. With detailed planning, including provision for bringing onto site temporary bulk generators, and the formulation of a 600-step switching programme, the replacement of potential faulty driver components in the disconnect mechanism for 20 HV switchgear panels was completed in just four weeks, with minimal interruption to the vast complex's power supply.

Requirements engineering for trust management: Model, methodology, and reasoning

NARCIS (Netherlands)

Giorgini, P.; Massacci, F.; Mylopoulos, J.; Zannone, N.

2006-01-01

A number of recent proposals aim to incorporate security engineering into mainstream software engineering. Yet, capturing trust and security requirements at an organizational level, as opposed to an IT system level, and mapping these into security and trust management policies is still an open

Overview of Risk Management for Engineered Nanomaterials

Science.gov (United States)

Schulte, P. A.; Geraci, C. L.; Hodson, L. L.; Zumwalde, R. D.; Kuempel, E. D.; Murashov, V.; Martinez, K. F.; Heidel, D. S.

2013-04-01

Occupational exposure to engineered nanomaterials (ENMs) is considered a new and challenging occurrence. Preliminary information from laboratory studies indicates that workers exposed to some kinds of ENMs could be at risk of adverse health effects. To protect the nanomaterial workforce, a precautionary risk management approach is warranted and given the newness of ENMs and emergence of nanotechnology, a naturalistic view of risk management is useful. Employers have the primary responsibility for providing a safe and healthy workplace. This is achieved by identifying and managing risks which include recognition of hazards, assessing exposures, characterizing actual risk, and implementing measures to control those risks. Following traditional risk management models for nanomaterials is challenging because of uncertainties about the nature of hazards, issues in exposure assessment, questions about appropriate control methods, and lack of occupational exposure limits (OELs) or nano-specific regulations. In the absence of OELs specific for nanomaterials, a precautionary approach has been recommended in many countries. The precautionary approach entails minimizing exposures by using engineering controls and personal protective equipment (PPE). Generally, risk management utilizes the hierarchy of controls. Ideally, risk management for nanomaterials should be part of an enterprise-wide risk management program or system and this should include both risk control and a medical surveillance program that assesses the frequency of adverse effects among groups of workers exposed to nanomaterials. In some cases, the medical surveillance could include medical screening of individual workers to detect early signs of work-related illnesses. All medical surveillance should be used to assess the effectiveness of risk management; however, medical surveillance should be considered as a second line of defense to ensure that implemented risk management practices are effective.

Overview of Risk Management for Engineered Nanomaterials

International Nuclear Information System (INIS)

Schulte, P A; Geraci, C L; Hodson, L L; Zumwalde, R D; Kuempel, E D; Murashov, V; Martinez, K F; Heidel, D S

2013-01-01

Occupational exposure to engineered nanomaterials (ENMs) is considered a new and challenging occurrence. Preliminary information from laboratory studies indicates that workers exposed to some kinds of ENMs could be at risk of adverse health effects. To protect the nanomaterial workforce, a precautionary risk management approach is warranted and given the newness of ENMs and emergence of nanotechnology, a naturalistic view of risk management is useful. Employers have the primary responsibility for providing a safe and healthy workplace. This is achieved by identifying and managing risks which include recognition of hazards, assessing exposures, characterizing actual risk, and implementing measures to control those risks. Following traditional risk management models for nanomaterials is challenging because of uncertainties about the nature of hazards, issues in exposure assessment, questions about appropriate control methods, and lack of occupational exposure limits (OELs) or nano-specific regulations. In the absence of OELs specific for nanomaterials, a precautionary approach has been recommended in many countries. The precautionary approach entails minimizing exposures by using engineering controls and personal protective equipment (PPE). Generally, risk management utilizes the hierarchy of controls. Ideally, risk management for nanomaterials should be part of an enterprise-wide risk management program or system and this should include both risk control and a medical surveillance program that assesses the frequency of adverse effects among groups of workers exposed to nanomaterials. In some cases, the medical surveillance could include medical screening of individual workers to detect early signs of work-related illnesses. All medical surveillance should be used to assess the effectiveness of risk management; however, medical surveillance should be considered as a second line of defense to ensure that implemented risk management practices are effective.

Introducing Knowledge Management in Study Program of Nuclear Engineering

International Nuclear Information System (INIS)

Pleslic, S.

2012-01-01

Nuclear engineering is the branch of engineering concerning application of the fission as well as the fusion of atomic nuclei, and the application of other sub-atomic physics, based on the principles of nuclear physics. In the sub-field of nuclear fission there are many investigations of interactions and maintaining of systems and components like nuclear reactors and nuclear power plants. The field also includes the study of different applications of ionizing radiation (medicine, agriculture...), nuclear safety, the problems of thermodynamics transport, nuclear materials and nuclear fuels, and other related technologies like radioactive waste management. In the area of nuclear science and engineering a big amount of knowledge has been accumulated over the last decades. Different levels of nuclear knowledge were considered in different ways and they were taught to different parts of population as a general human culture and as a general scientific-technical-technological culture (high schools, nuclear information centres, training centres, universities...). An advanced level of nuclear knowledge has been accumulated by many experienced workers, specialists and experts in all nuclear and nuclear-related fields and applications. In the last 20 years knowledge management has established itself as a discipline of enabling individuals, teams and whole organizations to create, share and apply knowledge collectively and systematically, with goal to better achieve their objectives. Also, knowledge management became key strategic approach for management of intellectual assets and knowledge that can improve safety, efficiency and innovation, and lead to preserve and enhance current knowledge. Knowledge management could be applied in education, training, networking, human resource development and capacity building, sharing, pooling and transferring knowledge form centres of knowledge to centres of growth. Considering the critical importance of nuclear knowledge it is important

Decision models in engineering and management

CERN Document Server

2015-01-01

Providing a comprehensive overview of various methods  and applications in decision engineering, this book presents chapters written by a range experts in the field. It presents conceptual aspects of decision support applications in various areas including finance, vendor selection, construction, process management, water management and energy, agribusiness , production scheduling and control, and waste management. In addition to this, a special focus is given to methods of multi-criteria decision analysis. Decision making in organizations is a recurrent theme and is essential for business continuity.  Managers from various fields including public, private, industrial, trading or service sectors are required to make decisions. Consequently managers need the support of these structured methods in order to engage in effective decision making. This book provides a valuable resource for graduate students, professors and researchers of decision analysis, multi-criteria decision analysis and group decision analys...

Diesel Engine Mechanics.

Science.gov (United States)

Foutes, William A.

Written in student performance terms, this curriculum guide on diesel engine repair is divided into the following eight sections: an orientation to the occupational field and instructional program; instruction in operating principles; instruction in engine components; instruction in auxiliary systems; instruction in fuel systems; instruction in…

An apology for primary repair of tetralogy of Fallot.

Science.gov (United States)

Van Arsdell, Glen; Yun, Tae-Jin

2005-01-01

The first repair of tetralogy of Fallot (TOF) was 50 years ago, so it would seem that the details for optimal management strategies would be clear. Timing of repair and operative repair strategy for TOF are still a source of debate. Varying institutions have published excellent outcomes with a primary repair strategy or a selective staged repair strategy. In this article, the current and historic strategy for repair of TOF at the Hospital for Sick Children in Toronto is delineated along with associated outcomes. Data from our institution indicate a clear survival advantage for primary repair of TOF.

Peripherally Inserted Central Catheters in Pediatric Patients: To Repair or Not Repair

International Nuclear Information System (INIS)

Gnannt, Ralph; Patel, Premal; Temple, Michael; Al Brashdi, Yahya; Amaral, Joao; Parra, Dimitri; Rea, Vanessa; Stephens, Derek; Connolly, Bairbre

2017-01-01

IntroductionPreservation of venous access in children is a major concern in pediatric interventional radiology. If a peripherally inserted central catheter (PICC) breaks, there are two options: repair the line with a repair kit or exchange the line over a wire in the interventional suite. The purpose of this study is to assess the outcome of PICC repairs in children and to compare these with the outcomes of PICC exchange.Materials and MethodsThis is a single-center, retrospective study of central line-associated bloodstream infection (CLABSI) following management of externally broken PICCs (2010–2014). The occurrence of CLABSI within 30 days after repair (Group A) or exchange (Group B) of a line was analyzed, as well as PICCs exchanged following an initial and failed repair.ResultsA total of 235 PICC breaks were included in the study, of which 161 were repaired, and 116 of whom were successful (68%, Group A). No repair was performed in 74 PICCs—55/74 of these were exchanged over a wire (74%, Group B), and 19/74 lines were removed. The 30 days post-repair CLABSI rate (Group A) was 2.0 infections per 1000 catheter days, and the calculated risk was 4.3%. In comparison the 30 days post-exchange CLABSI rate (Group B) was 4.0 per 1000 catheter days and the calculated risk 10.9%. This difference was significant when adjusted for antibiotic use (OR 3.87; 95% CI 1.07–14.0, p = 0.039).ConclusionThe results of this study support repairing a broken PICC instead of removing or replacing the line.

Peripherally Inserted Central Catheters in Pediatric Patients: To Repair or Not Repair

Energy Technology Data Exchange (ETDEWEB)

Gnannt, Ralph, E-mail: ralph.gnannt@usz.ch; Patel, Premal; Temple, Michael; Al Brashdi, Yahya; Amaral, Joao; Parra, Dimitri; Rea, Vanessa [University of Toronto, Image Guided Therapy, Diagnostic Imaging, The Hospital for Sick Children (Canada); Stephens, Derek [University of Toronto, Child Health Evaluative Sciences (Canada); Connolly, Bairbre [University of Toronto, Image Guided Therapy, Diagnostic Imaging, The Hospital for Sick Children (Canada)

2017-06-15

IntroductionPreservation of venous access in children is a major concern in pediatric interventional radiology. If a peripherally inserted central catheter (PICC) breaks, there are two options: repair the line with a repair kit or exchange the line over a wire in the interventional suite. The purpose of this study is to assess the outcome of PICC repairs in children and to compare these with the outcomes of PICC exchange.Materials and MethodsThis is a single-center, retrospective study of central line-associated bloodstream infection (CLABSI) following management of externally broken PICCs (2010–2014). The occurrence of CLABSI within 30 days after repair (Group A) or exchange (Group B) of a line was analyzed, as well as PICCs exchanged following an initial and failed repair.ResultsA total of 235 PICC breaks were included in the study, of which 161 were repaired, and 116 of whom were successful (68%, Group A). No repair was performed in 74 PICCs—55/74 of these were exchanged over a wire (74%, Group B), and 19/74 lines were removed. The 30 days post-repair CLABSI rate (Group A) was 2.0 infections per 1000 catheter days, and the calculated risk was 4.3%. In comparison the 30 days post-exchange CLABSI rate (Group B) was 4.0 per 1000 catheter days and the calculated risk 10.9%. This difference was significant when adjusted for antibiotic use (OR 3.87; 95% CI 1.07–14.0, p = 0.039).ConclusionThe results of this study support repairing a broken PICC instead of removing or replacing the line.

Detection of abnormalities in the superficial zone of cartilage repaired using a tissue engineered construct derived from synovial stem cells

Directory of Open Access Journals (Sweden)

W Ando

2012-09-01

Full Text Available The present study investigated the surface structure and mechanical properties of repair cartilage generated from a tissue engineered construct (TEC derived from synovial mesenchymal stem cells at six months post-implantation compared to those of uninjured cartilage. TEC-mediated repair tissue was cartilaginous with Safranin O staining, and had comparable macro-scale compressive properties with uninjured cartilage. However, morphological assessments revealed that the superficial zone of TEC-mediated tissue was more fibrocartilage-like, in contrast to the middle or deep zones that were more hyaline cartilage-like with Safranin O staining. Histological scoring of the TEC-mediated tissue was significantly lower in the superficial zone than in the middle and deep zones. Scanning electron microscopy showed a thick tangential bundle of collagen fibres at the most superficial layer of uninjured cartilage, while no corresponding structure was detected at the surface of TEC-mediated tissue. Immunohistochemical analysis revealed that PRG4 was localised in the superficial area of uninjured cartilage, as well as the TEC-mediated tissue. Friction testing showed that the lubrication properties of the two tissues was similar, however, micro-indentation analysis revealed that the surface stiffness of the TEC-repair tissue was significantly lower than that of uninjured cartilage. Permeability testing indicated that the TEC-mediated tissue exhibited lower water retaining capacity than did uninjured cartilage, specifically at the superficial zone. Thus, TEC-mediated tissue exhibited compromised mechanical properties at the superficial zone, properties which need improvement in the future for maintenance of long term repair cartilage integrity.

Detection of abnormalities in the superficial zone of cartilage repaired using a tissue engineered construct derived from synovial stem cells.

Science.gov (United States)

Ando, Wataru; Fujie, Hiromichi; Moriguchi, Yu; Nansai, Ryosuke; Shimomura, Kazunori; Hart, David A; Yoshikawa, Hideki; Nakamura, Norimasa

2012-09-28

The present study investigated the surface structure and mechanical properties of repair cartilage generated from a tissue engineered construct (TEC) derived from synovial mesenchymal stem cells at six months post-implantation compared to those of uninjured cartilage. TEC-mediated repair tissue was cartilaginous with Safranin O staining, and had comparable macro-scale compressive properties with uninjured cartilage. However, morphological assessments revealed that the superficial zone of TEC-mediated tissue was more fibrocartilage-like, in contrast to the middle or deep zones that were more hyaline cartilage-like with Safranin O staining. Histological scoring of the TEC-mediated tissue was significantly lower in the superficial zone than in the middle and deep zones. Scanning electron microscopy showed a thick tangential bundle of collagen fibres at the most superficial layer of uninjured cartilage, while no corresponding structure was detected at the surface of TEC-mediated tissue. Immunohistochemical analysis revealed that PRG4 was localised in the superficial area of uninjured cartilage, as well as the TEC-mediated tissue. Friction testing showed that the lubrication properties of the two tissues was similar, however, micro-indentation analysis revealed that the surface stiffness of the TEC-repair tissue was significantly lower than that of uninjured cartilage. Permeability testing indicated that the TEC-mediated tissue exhibited lower water retaining capacity than did uninjured cartilage, specifically at the superficial zone. Thus, TEC-mediated tissue exhibited compromised mechanical properties at the superficial zone, properties which need improvement in the future for maintenance of long term repair cartilage integrity.

The strategies of local farmers' water management and the eco-hydrological effects of irrigation-drainage engineering systems in world heritage of Honghe Hani Rice Terraces

Science.gov (United States)

Gao, Xuan

2017-04-01

Terraces are built in mountainous regions to provide larger area for cultivation,in which the hydrological and geomorphological processes are impacted by local farmers' water management strategies and are modified by manmade irrigation-drainage engineering systems.The Honghe Hani Rice Terraces is a 1300a history of traditional agricultural landscape that was inscribed in the 2013 World Heritage List.The local farmers had developed systematic water management strategies and built perfect irrigation-drainage engineering systems to adapt the local rainfall pattern and rice farming activities.Through field investigation,interviews,combined with Geographic Information Systems,Remote Sensing images and Global Positioning Systems technology,the water management strategies as well as the irrigation-drainage systems and their impacts on eco-hydrological process were studied,the results indicate:Firstly,the local people created and maintained an unique woodcarving allocating management system of irrigating water over hundreds years,which aids distributing water and natural nutrition to each terrace field evenly,and regularly according to cultivation schedule.Secondly,the management of local people play an essential role in effective irrigation-drainage engineering system.A ditch leader takes charge of managing the ditch of their village,keeping ample amount of irrigation water,repairing broken parts of ditches,dealing with unfair water using issues,and so on.Meanwhile,some traditional leaders of minority also take part in.Thus, this traditional way of irrigation-drainage engineering has bringed Hani people around 1300 years of rice harvest for its eco-hydrological effects.Lastly we discuss the future of Honghe Hani Rice Terraces,the traditional cultivation pattern has been influenced by the rapid development of modern civilization,in which some related changes such as the new equipment of county roads and plastic channels and the water overusing by tourism are not totally

Primary repair of colon injuries: clinical study of nonselective approach

Directory of Open Access Journals (Sweden)

Krivokapic Zoran V

2010-12-01

Full Text Available Abstract Background This study was designed to determine the role of primary repair and to investigate the possibility of expanding indications for primary repair of colon injuries using nonselective approach. Methods Two groups of patients were analyzed. Retrospective (RS group included 30 patients managed by primary repair or two stage surgical procedure according to criteria published by Stone (S/F and Flint (Fl. In this group 18 patients were managed by primary repair. Prospective (PR group included 33 patients with primary repair as a first choice procedure. In this group, primary repair was performed in 30 cases. Results Groups were comparable regarding age, sex, and indexes of trauma severity. Time between injury and surgery was shorter in PR group, (1.3 vs. 3.1 hours. Stab wounds were more frequent in PR group (9:2, and iatrogenic lesions in RS group (6:2. Associated injuries were similar, as well as segmental distribution of colon injuries. S/F criteria and Flint grading were similar. In RS group 15 primary repairs were successful, while in two cases relaparotomy and colostomy was performed due to anastomotic leakage. One patient died. In PR group, 25 primary repairs were successful, with 2 immediate and 3 postoperative (7-10 days deaths, with no evidence of anastomotic leakage. Conclusions Results of this study justify more liberal use of primary repair in early management of colon injuries. Trial registration Current Controlled Trials ISRCTN94682396

From Design to Production Control Through the Integration of Engineering Data Management and Workflow Management Systems

CERN Document Server

Le Goff, J M; Bityukov, S; Estrella, F; Kovács, Z; Le Flour, T; Lieunard, S; McClatchey, R; Murray, S; Organtini, G; Vialle, J P; Bazan, A; Chevenier, G

1997-01-01

At a time when many companies are under pressure to reduce "times-to-market" the management of product information from the early stages of design through assembly to manufacture and production has become increasingly important. Similarly in the construction of high energy physics devices the collection of ( often evolving) engineering data is central to the subsequent physics analysis. Traditionally in industry design engineers have employed Engineering Data Management Systems ( also called Product Data Management Systems) to coordinate and control access to documented versions of product designs. However, these systems provide control only at the collaborative design level and are seldom used beyond design. Workflow management systems, on the other hand, are employed in industry to coordinate and support the more complex and repeatable work processes of the production environment. Commer cial workflow products cannot support the highly dynamic activities found both in the design stages of product developmen...

Building Management and ICT Learning in Civil Engineering Education

DEFF Research Database (Denmark)

Christiansson, Per Lennart

2005-01-01

The paper presents structures of the learning domains of building informatics exemplified with experiences from building management civil engineering and open education in Industrial IT at Aalborg University. The courses cover areas such as; object oriented programming and relational database...... design, human computer interface, user environment design and usability engineering, computer supported collaborative working, knowledge management, virtual buildings, intelligent buildings, and building systems simulation. Experiences from many years involvement in ICT supported learning and development...... taking into account improvement of learning styles, course content and learning material is also reported....

Efficient Spatial Data Structure for Multiversion Management of Engineering Drawings

Directory of Open Access Journals (Sweden)

Yasuaki Nakamura

2004-08-01

Full Text Available In the engineering database system, multiple versions of a design including engineering drawings should be managed efficiently. The paper proposes an extended spatial data structure for efficient management of multiversion engineering drawings. The R-tree is adapted as a basic data structure. The efficient mechanism to manage the difference between drawings is introduced to the R-tree to eliminate redundant duplications and to reduce the amount of storage required for the data structure. The extended data structures of the R-tree, MVR and MVR* trees, are developed and the performances of these trees are evaluated. A series of simulation tests shows that, compared with the basic R-tree, the amounts of storage required for the MVR and MVR* trees are reduced to 50% and 30%, respectively. The search efficiencies of the R, MVR, and MVR* trees are almost the same.

Diesel Engine Technician

Science.gov (United States)

Tech Directions, 2010

2010-01-01

Diesel engine technicians maintain and repair the engines that power transportation equipment such as heavy trucks, trains, buses, and locomotives. Some technicians work mainly on farm machines, ships, compressors, and pumps. Others work mostly on construction equipment such as cranes, power shovels, bulldozers, and paving machines. This article…

Allogeneic versus autologous derived cell sources for use in engineered bone-ligament-bone grafts in sheep anterior cruciate ligament repair.

Science.gov (United States)

Mahalingam, Vasudevan D; Behbahani-Nejad, Nilofar; Horine, Storm V; Olsen, Tyler J; Smietana, Michael J; Wojtys, Edward M; Wellik, Deneen M; Arruda, Ellen M; Larkin, Lisa M

2015-03-01

The use of autografts versus allografts for anterior cruciate ligament (ACL) reconstruction is controversial. The current popular options for ACL reconstruction are patellar tendon or hamstring autografts, yet advances in allograft technologies have made allogeneic grafts a favorable option for repair tissue. Despite this, the mismatched biomechanical properties and risk of osteoarthritis resulting from the current graft technologies have prompted the investigation of new tissue sources for ACL reconstruction. Previous work by our lab has demonstrated that tissue-engineered bone-ligament-bone (BLB) constructs generated from an allogeneic cell source develop structural and functional properties similar to those of native ACL and vascular and neural structures that exceed those of autologous patellar tendon grafts. In this study, we investigated the effectiveness of our tissue-engineered ligament constructs fabricated from autologous versus allogeneic cell sources. Our preliminary results demonstrate that 6 months postimplantation, our tissue-engineered auto- and allogeneic BLB grafts show similar histological and mechanical outcomes indicating that the autologous grafts are a viable option for ACL reconstruction. These data indicate that our tissue-engineered autologous ligament graft could be used in clinical situations where immune rejection and disease transmission may preclude allograft use.

BMCloud: Minimizing Repair Bandwidth and Maintenance Cost in Cloud Storage

Directory of Open Access Journals (Sweden)

Chao Yin

2013-01-01

Full Text Available To protect data in cloud storage, fault tolerance and efficient recovery become very important. Recent studies have developed numerous solutions based on erasure code techniques to solve this problem using functional repairs. However, there are two limitations to address. The first one is consistency since the Encoding Matrix (EM is different among clouds. The other one is repairing bandwidth, which is a concern for most of us. We addressed these two problems from both theoretical and practical perspectives. We developed BMCloud, a new low repair bandwidth, low maintenance cost cloud storage system, which aims to reduce repair bandwidth and maintenance cost. The system employs both functional repair and exact repair while it inherits advantages from the both. We propose the JUDGE_STYLE algorithm, which can judge whether the system should adopt exact repair or functional repair. We implemented a networked storage system prototype and demonstrated our findings. Compared with existing solutions, BMCloud can be used in engineering to save repair bandwidth and degrade maintenance significantly.

Sequelae of Endoscopic Inguinal Hernia Repair : Incidence, evaluation and management

NARCIS (Netherlands)

Burgmans, J.P.J.

2015-01-01

The endoscopic preperitoneal technique (TEP) is an appealing inguinal hernia repair technique, theoretically superior to other approaches. In practice some problems remain unsolved. Real incidences of chronic postoperative inguinal pain (CPIP) and other important sequelae of endoscopic hernia repair

Pengalokasian Tenaga Kerja dengan Human Factor Engineering di PT. Pelindo I

Directory of Open Access Journals (Sweden)

Yusnawati Yusnawati

2017-05-01

Full Text Available Indonesia Port Corporation I (PT Pelabuhan Indonesia I (Persero or PT. Pelindo I is one of the Indonesian state-owned enterprises which manages port services in western Indonesia. Shipyard unit (Unit Galangan Kapal (UGK is a branch of PT. Pelindo I. At present, a problem arises if more than 2 ships are being repaired at once in the unit, UGK scheduling overlaps the repairing activities. In order to solve the problem, study of human factor is important. Human factor is the study of the limitations, capabilities, and human behavior, as well as its interaction with the product, environment, equipment and the establishment of tasks and activities. One part of the human factor is the human factor in system design. In order to improve the effectiveness of the system, the human factor must be involved in each phase of the design process in the system design. This includes a number of activities to obtain input specification work, therefore the working methods and the optimal amount of labor can be determined. Human factors engineering is the application of science that utilizes research on the human factor and use the basic knowledge to design, to repair and to install the system. This research method is causal, searching for the causes which led to delays in the completion of ship repairing. Through human factor engineering approach to the allocation of labor increased by 12.23 per cent of the actual conditions, so that the delay of ship repair were not found during normal conditions.

Organization and management of heterogeneous, dispersed data bases in nuclear engineering

International Nuclear Information System (INIS)

Eastman, C.M.

1986-01-01

Large, complex, multiperson engineering projects in many areas, nuclear, aerospace, electronics, and manufacturing, have inherent needs for coordination, control, and management of the related engineering data. Taken in the abstract, the notion of an integrated engineering data base (IED) for such projects is attractive. The potential capabilities of an (IED) are that all data are managed in a coordinated way, are made accessible to all users who need it, allow relations between all parts of the data to be tracked and managed, provide backup, recovery, audit trails, security and access control, and allow overall project status to be monitored and managed. Common data accessing schemes and user interfaces to applications are also part of an IED. This paper describes a new software product that allows incremental realization of many of the capabilities of an IED, without the massive disruption and risk

Biomechanics and mechanobiology in functional tissue engineering

Science.gov (United States)

Guilak, Farshid; Butler, David L.; Goldstein, Steven A.; Baaijens, Frank P.T.

2014-01-01

The field of tissue engineering continues to expand and mature, and several products are now in clinical use, with numerous other preclinical and clinical studies underway. However, specific challenges still remain in the repair or regeneration of tissues that serve a predominantly biomechanical function. Furthermore, it is now clear that mechanobiological interactions between cells and scaffolds can critically influence cell behavior, even in tissues and organs that do not serve an overt biomechanical role. Over the past decade, the field of “functional tissue engineering” has grown as a subfield of tissue engineering to address the challenges and questions on the role of biomechanics and mechanobiology in tissue engineering. Originally posed as a set of principles and guidelines for engineering of load-bearing tissues, functional tissue engineering has grown to encompass several related areas that have proven to have important implications for tissue repair and regeneration. These topics include measurement and modeling of the in vivo biomechanical environment; quantitative analysis of the mechanical properties of native tissues, scaffolds, and repair tissues; development of rationale criteria for the design and assessment of engineered tissues; investigation of the effects biomechanical factors on native and repair tissues, in vivo and in vitro; and development and application of computational models of tissue growth and remodeling. Here we further expand this paradigm and provide examples of the numerous advances in the field over the past decade. Consideration of these principles in the design process will hopefully improve the safety, efficacy, and overall success of engineered tissue replacements. PMID:24818797

Rocket Engine Health Management: Early Definition of Critical Flight Measurements

Science.gov (United States)

Christenson, Rick L.; Nelson, Michael A.; Butas, John P.

2003-01-01

The NASA led Space Launch Initiative (SLI) program has established key requirements related to safety, reliability, launch availability and operations cost to be met by the next generation of reusable launch vehicles. Key to meeting these requirements will be an integrated vehicle health management ( M) system that includes sensors, harnesses, software, memory, and processors. Such a system must be integrated across all the vehicle subsystems and meet component, subsystem, and system requirements relative to fault detection, fault isolation, and false alarm rate. The purpose of this activity is to evolve techniques for defining critical flight engine system measurements-early within the definition of an engine health management system (EHMS). Two approaches, performance-based and failure mode-based, are integrated to provide a proposed set of measurements to be collected. This integrated approach is applied to MSFC s MC-1 engine. Early identification of measurements supports early identification of candidate sensor systems whose design and impacts to the engine components must be considered in engine design.

A Study On The Practical Application Of Repair Development Methods For Aerospace Components

Science.gov (United States)

Moedano, Jesus A.

In the industry of manufacturing, each gas turbine engine component begins in a raw state such as bar stock and is routed through manufacturing processes to define its final form before being installed on the engine. What is the follow-up to this part? What happens when over time and usage it wears? Several factors have created a section of the manufacturing industry known as aftermarket to support the customer in their need for restoration and repair of their original product. Once a product has reached a wear factor or cycle limit that cannot be ignored, one of the options is to have it repaired to maintain use of the core. This research investigated the study into the creation and application of repair development methodology that can be utilized by current and new manufacturing engineers of the world. Those who have been in this field for some time will find the process thought provoking while the engineering students can develop a foundation of thinking to prepare for the common engineering problems they will be tasked to resolve. The examples, figures and tables are true issues of the industry though the data will have been changed due to proprietary factors. The results of the study reveals, under most scenarios, a solid process can be followed to proceed with the best options for repair based on the initial discrepancy. However, this methodology will not be a "catch-all" process but a guidance that will develop the proper thinking in evaluation of the repair options and the possible failure modes of each choice. As with any continuous improvement tool, further research is needed to test the applicability of this process in other fields.

General Mechanical Repair. Minor Automotive Maintenance. Volume 1. Teacher's Guide.

Science.gov (United States)

East Texas State Univ., Commerce. Occupational Curriculum Lab.

Fourteen units on minor automotive maintenance are presented in this teacher's guide. The units are the following: introduction to minor automotive maintenance, shop safety, engine principles, fuel system operation and repair, electrical system, ignition system, lubrication system, engine cooling system, exhaust system, wheel bearings and tires,…

Repair process and a repaired component

Energy Technology Data Exchange (ETDEWEB)

Roberts, III, Herbert Chidsey; Simpson, Stanley F.

2018-02-20

Matrix composite component repair processes are disclosed. The matrix composite repair process includes applying a repair material to a matrix composite component, securing the repair material to the matrix composite component with an external securing mechanism and curing the repair material to bond the repair material to the matrix composite component during the securing by the external securing mechanism. The matrix composite component is selected from the group consisting of a ceramic matrix composite, a polymer matrix composite, and a metal matrix composite. In another embodiment, the repair process includes applying a partially-cured repair material to a matrix composite component, and curing the repair material to bond the repair material to the matrix composite component, an external securing mechanism securing the repair material throughout a curing period, In another embodiment, the external securing mechanism is consumed or decomposed during the repair process.

Self-managing teams in manufacturing companies: implications for the engineering function

NARCIS (Netherlands)

Leede, de Jan; Stoker, Janka

Reports on an explanatory multiple case-study of companies with self-managing teams. Reasons for introducing self-managing teams; Cooperation between self-managing teams and engineering development; Conclusion.

Nanofiber Nerve Guide for Peripheral Nerve Repair and Regeneration

Science.gov (United States)

2016-04-01

1 Award Number: W81XWH-11-2-0047 TITLE: Nanofiber Nerve Guide for Peripheral Nerve Repair and Regeneration PRINCIPAL INVESTIGATOR: Ahmet Höke...TITLE AND SUBTITLE 5a. CONTRACT NUMBER W81XWH-11-2-0047 Nanofiber nerve guide for peripheral nerve repair and regeneration 5b. GRANT NUMBER...goal of this collaborative research project was to develop next generation engineered nerve guide conduits (NGCs) with aligned nanofibers and

Applied Ontology Engineering in Cloud Services, Networks and Management Systems

CERN Document Server

Serrano Orozco, J Martín

2012-01-01

Metadata standards in today’s ICT sector are proliferating at unprecedented levels, while automated information management systems collect and process exponentially increasing quantities of data. With interoperability and knowledge exchange identified as a core challenge in the sector, this book examines the role ontology engineering can play in providing solutions to the problems of information interoperability and linked data. At the same time as introducing basic concepts of ontology engineering, the book discusses methodological approaches to formal representation of data and information models, thus facilitating information interoperability between heterogeneous, complex and distributed communication systems. In doing so, the text advocates the advantages of using ontology engineering in telecommunications systems. In addition, it offers a wealth of guidance and best-practice techniques for instances in which ontology engineering is applied in cloud services, computer networks and management systems. �...

The T-Shape dilemma in industrial engineering and management curriculum

Directory of Open Access Journals (Sweden)

Sigal Koral Kordova

2014-10-01

Full Text Available Purpose: This paper deals with the undergraduate “Industrial Engineering and Management” curriculum. The research’s purpose was to examine the in-depth coverage of teaching/learning in the combined field of industrial engineering and management, as opposed to the extent of widthwise multidisciplinary teaching/learning in this field (T-Shape dilemma. According to this purpose, the following research question was derived: With respect to widthwise multidisciplinary teaching and the depth extent of teaching in industrial engineering and management, what is the desired situation as opposed to the actual situation? Design/methodology/approach: In order to examine the T-shape dilemma, 16 in-depth interviews were conducted with senior-level managers in industry, and with leading academics in the fields of industrial engineering and management. The interviewees were asked questions regarding the planning and design of the curriculum in these fields. An analysis of the interviews was carried out by dividing the interviews into categories, and presenting the categories with the highest frequency occurring in all of the interviews. Findings and Originality/value: One of the most significant results was the great variability between the answers of senior-level managers in industry and those of the academics. While individuals in the business field (senior-level managers place great importance on focusing studies on the management-business aspect, and acquiring multidisciplinary knowledge, academics emphasized the great importance of understanding the theories and rationale behind the learned material, acquiring a strong theoretical basis, and studying the basic principles, whose implementation is then expressed in a wide diversity of applications. Research limitations/implications: Owing to time limitations, the research only included 16 in-depth interviews. In order to enlarge the external validity of this research more interviews should be executed

Combustion pressure-based engine management system

Energy Technology Data Exchange (ETDEWEB)

Mueller, R.; Hart, M. [DaimlerChrysler, Stuttart (Germany); Truscott, A.; Noble, A. [Ricardo, Shoreham-by-Sea (United Kingdom); Kroetz, G.; Richter, C. [DaimlerChrysler, Munchen (Germany); Cavalloni, C. [Kistler Instruments AG, Winterthur (Switzerland)

2000-07-01

In order to fulfill future emissions and OBD regulations, whilst meeting increasing demands for driveability and refinement, new technologies for SI engines have to be found in terms of sensors and algorithms for engine control units. One promising way, explored in the AENEAS collaborative project between DaimlerChrysler, Kistler, Ricardo and the European Commission, is to optimize the behavior of the system by using in-cylinder measurements and analysing them with modern control algorithms. In this paper a new engine management system based on combustion pressure sensing is presented. The pressure sensor is designed to give a reliable and accurate signal of the full pressure trace during a working cycle. With the application of new technologies low cost manufacturing appears to be achievable, so that an application in mass production can be considered. Furthermore, model-based algorithms were developed to allow optimal control of the engine based on the in-cylinder measurements. The algorithms incorporate physical principles to improve efficiency, emissions and to reduce the parameterisation effort. In the paper, applications of the combustion pressure signal for air mass estimation, knock detection, ignition control cam phase detection and diagnosis are discussed. (author)

Current concepts in repair of extremity venous injury.

Science.gov (United States)

Williams, Timothy K; Clouse, W Darrin

2016-04-01

Extremity venous injury management remains controversial. The purpose of this communication is to offer perspective as well as experiential and technical insight into extremity venous injury repair. Available literature is reviewed and discussed. Historical context is provided. Indication, the decision process for repair, including technical conduct, is delineated. In particular, the authors' experiences in both civilian and wartime injury are used for perspective. Extremity venous injury repair was championed within data from the Vietnam Vascular Registry. However, patterns of extremity venous injury differ between combat and civilian settings. Since Vietnam, civilian descriptive series opine the benefits and potential complications associated with both venous injury repair and ligation. These surround extremity edema, chronic venous insufficiency, thromboembolism, and limb loss. Whereas no clear superiority in either approach has been identified to date, there appears to be no increased risk of pulmonary embolism or chronic venous changes with repair. Newer data from the wars in Iraq and Afghanistan and meta-analysis have reinforced this and also have suggested limb salvage benefit for extremity venous repair in combined arterial and venous injuries in modern settings. The patient's physiologic state and associated injury drive five triage categories suggesting vein injury management. Vein repair thrombosis occurs in a significant proportion, yet many recanalize and possibly have a positive impact on limb venous return. Further, early decompression favors reduced blood loss, acute edema, and inflammation, supporting collateral development. Large soft tissue injury minimizing collateral capacity increases the importance of repair. Constructs of repair are varied with modest differences in patency. Venous shunting is feasible, but specific roles remain nebulous. An aggressive posture toward extremity venous injury repair seems justified today because of the likely

Peripheral nerve repair: a hot spot analysis on treatment methods from 2010 to 2014

Directory of Open Access Journals (Sweden)

Guang-yao Liu

2015-01-01

Full Text Available Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research. Advances in basic research in recent years have increased our understanding of the anatomy of peripheral nerves and the importance of the microenvironment. Various new intervention methods have been developed, but with varying effectiveness. In the present study, we selected 911 papers on different repair methods for peripheral nerve injury from the Web of Science and indexed in the Science Citation Index from 2010 to 2014. We quantitatively examine new repair methods and strategies using bibliometrics, and we discuss the present state of knowledge and the problems and prospects of various repair methods, including nerve transfer, neural transplantation, tissue engineering and genetic engineering. Our findings should help in the study and development of repair methods for peripheral nerve injury.

Engineering management at feasibility study stage of nuclear power plant under EPC mode

International Nuclear Information System (INIS)

Wang Zhiqiang

2015-01-01

After the investment reform by the State Council in 2004, NDRC carries out approval system for enterprises to invest in nuclear power plants. Feasibility study stage is a critical stage on the mainline of nuclear power project approval, which intersects with the license application, and engineering design. The owners of nuclear power plants are required stringently in engineering management. From the owners' management point of view under EPC mode, this paper sorts the preliminary project process for nuclear power plants, focusing on the management in the feasibility study stage. License application and engineering design management in the feasibility study stage are also discussed. (author)

Surgical repair of a congenital pericardial diaphragmatic hernia

International Nuclear Information System (INIS)

Wright, R.P.; Wright, R.; Scott, R.

1987-01-01

Objective: To describe the surgical repair and pre- and postoperative management of a peritoneopericardial diaphragmatic hernia (PPDH) in a pregnant dog. Case summary: A pregnant dog was presented for vomiting, lethargy, and pale mucous membranes. Pulsus paradoxus was noted on physical examination. The dog was diagnosed with a PPDH via thoracic radiographs, abdominal ultrasound, and a n echocardiogram. The hernia was surgically repaired and the dog received supportive medical care until the puppies were old enough to be delivered via cesarean section. The mother and all puppies survived. New or unique information provided: This is the first report that describes the surgical repair and postoperative management of a PPDH in a pregnant dog

Extracellular matrix and tissue engineering applications

NARCIS (Netherlands)

Fernandes, H.A.M.; Moroni, Lorenzo; van Blitterswijk, Clemens; de Boer, Jan

2009-01-01

The extracellular matrix is a key component during regeneration and maintenance of tissues and organs, and it therefore plays a critical role in successful tissue engineering as well. Tissue engineers should recognise that engineering technology can be deduced from natural repair processes. Due to

Knowledge management in the engineering design environment

Science.gov (United States)

Briggs, Hugh C.

2006-01-01

The Aerospace and Defense industry is experiencing an increasing loss of knowledge through workforce reductions associated with business consolidation and retirement of senior personnel. Significant effort is being placed on process definition as part of ISO certification and, more recently, CMMI certification. The process knowledge in these efforts represents the simplest of engineering knowledge and many organizations are trying to get senior engineers to write more significant guidelines, best practices and design manuals. A new generation of design software, known as Product Lifecycle Management systems, has many mechanisms for capturing and deploying a wider variety of engineering knowledge than simple process definitions. These hold the promise of significant improvements through reuse of prior designs, codification of practices in workflows, and placement of detailed how-tos at the point of application.

Improved criteria for the repair of fabrication flaws

International Nuclear Information System (INIS)

Doctor, S.R.; Schuster, G.J.; Simonen, F.A.

2003-01-01

Section III of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code for nuclear power plant components requires radiographic examinations (RT) of welds and requires repairs for RT indications that exceed code acceptable sizes. This paper describes research that has generated data on welding flaws, which indicated that the largest flaws occur in repaired welds. The fabrication flaws were detected in material removed from cancelled nuclear power plants using high sensitivity Nondestructive Examination (NDE) and validated by complementary NDE and destructive testing. Evidence suggests that repairs are often for small and benign RT indications at locations buried within the vessel or pipe wall. Probabilistic fracture mechanics calculations are described in this paper to predict the increases in vessel failure probabilities caused by the repair-induced flaws. Calculations address failures of embrittled vessel welds for pressurized thermal shock (PTS) transients. In this case small flaws, which are relatively common, can cause brittle fracture, such that the rarely encountered repair flaws of large sizes gave only modestly increased failure probabilities. The paper recommends the use of more discriminating ultrasonic examinations in place of RT examinations along with repair criteria based on a fitness-for-purpose approach that minimize the number of unjustified repairs. (author)

The 23rd Annual Meeting of the European Tissue Repair Society (ETRS) in Reims, France

NARCIS (Netherlands)

Hoff, J.W. Von den; Agren, M.S.; Coulomb, B.; Eming, S.A.; Lataillade, J.J.

2014-01-01

The 23rd Annual Meeting of the European Tissue Repair Society, Reims, France, October 23 to 25, 2013 focused on tissue repair and regenerative medicine covering topics such as stem cells, biomaterials, tissue engineering, and burns.

Neurogenesis and brain injury: managing a renewable resource for repair

OpenAIRE

Hallbergson, Anna F.; Gnatenco, Carmen; Peterson, Daniel A.

2003-01-01

The brain shows limited ability to repair itself, but neurogenesis in certain areas of the adult brain suggests that neural stem cells may be used for structural brain repair. It will be necessary to understand how neurogenesis in the adult brain is regulated to develop strategies that harness neural stem cells for therapeutic use.

System Engineering Management and Implementation Plan for Project W-211, ''Initial Tank Retrieval Systems'' (ITRS)

International Nuclear Information System (INIS)

VAN BEEK, J.E.

2000-01-01

This systems Engineering Management and Implementation Plan (SEMIP) describes the Project W-211 implementation of the Tank Farm Contractor Systems Engineering Management Plan (TFC SEMP). The SEMIP defines the systems engineering products and processes used by the project to comply with the TFC SEMP, and provides the basis for tailoring systems engineering processes by applying a graded approach to identify appropriate systems engineering requirements for W-211

System Engineering Management and Implementation Plan for Project W-211 Initial Tank Retrieval Systems (ITRS)

Energy Technology Data Exchange (ETDEWEB)

VAN BEEK, J.E.

2000-05-05

This systems Engineering Management and Implementation Plan (SEMIP) describes the Project W-211 implementation of the Tank Farm Contractor Systems Engineering Management Plan (TFC SEMP). The SEMIP defines the systems engineering products and processes used by the project to comply with the TFC SEMP, and provides the basis for tailoring systems engineering processes by applying a graded approach to identify appropriate systems engineering requirements for W-211.

Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair.

Science.gov (United States)

Tandon, Biranche; Blaker, Jonny J; Cartmell, Sarah H

2018-04-16

The process of bone repair and regeneration requires multiple physiological cues including biochemical, electrical and mechanical - that act together to ensure functional recovery. Myriad materials have been explored as bioactive scaffolds to deliver these cues locally to the damage site, amongst these piezoelectric materials have demonstrated significant potential for tissue engineering and regeneration, especially for bone repair. Piezoelectric materials have been widely explored for power generation and harvesting, structural health monitoring, and use in biomedical devices. They have the ability to deform with physiological movements and consequently deliver electrical stimulation to cells or damaged tissue without the need of an external power source. Bone itself is piezoelectric and the charges/potentials it generates in response to mechanical activity are capable of enhancing bone growth. Piezoelectric materials are capable of stimulating the physiological electrical microenvironment, and can play a vital role to stimulate regeneration and repair. This review gives an overview of the association of piezoelectric effect with bone repair, and focuses on state-of-the-art piezoelectric materials (polymers, ceramics and their composites), the fabrication routes to produce piezoelectric scaffolds, and their application in bone repair. Important characteristics of these materials from the perspective of bone tissue engineering are highlighted. Promising upcoming strategies and new piezoelectric materials for this application are presented. Electrical stimulation/electrical microenvironment are known effect the process of bone regeneration by altering the cellular response and are crucial in maintaining tissue functionality. Piezoelectric materials, owing to their capability of generating charges/potentials in response to mechanical deformations, have displayed great potential for fabricating smart stimulatory scaffolds for bone tissue engineering. The growing

Bringing knowledge management into an engineering curriculum ...

African Journals Online (AJOL)

The use of effective knowledge management is becoming an essential part of technical development projects in order to enable developers to handle the growing complexity of these projects. In this article we discuss an innovative approach to address this concern from the perspective of an undergraduate engineering ...

Service Cart For Engines

Science.gov (United States)

Ng, Gim Shek

1995-01-01

Cart supports rear-mounted air-cooled engine from Volkswagen or Porsche automobile. One person removes, repairs, tests, and reinstalls engine of car, van, or home-built airplane. Consists of framework of wood, steel, and aluminum components supported by four wheels. Engine lifted from vehicle by hydraulic jack and gently lowered onto waiting cart. Jack removed from under engine. Rear of vehicle raised just enough that engine can be rolled out from under it. Cart easily supports 200-lb engine. Also used to hold transmission. With removable sheet-metal top, cart used as portable seat.

Intelligent energy management control of vehicle air conditioning system coupled with engine

International Nuclear Information System (INIS)

Khayyam, Hamid; Abawajy, Jemal; Jazar, Reza N.

2012-01-01

Vehicle Air Conditioning (AC) systems consist of an engine powered compressor activated by an electrical clutch. The AC system imposes an extra load to the vehicle's engine increasing the vehicle fuel consumption and emissions. Energy management control of the vehicle air conditioning is a nonlinear dynamic system, influenced by uncertain disturbances. In addition, the vehicle energy management control system interacts with different complex systems, such as engine, air conditioning system, environment, and driver, to deliver fuel consumption improvements. In this paper, we describe the energy management control of vehicle AC system coupled with vehicle engine through an intelligent control design. The Intelligent Energy Management Control (IEMC) system presented in this paper includes an intelligent algorithm which uses five exterior units and three integrated fuzzy controllers to produce desirable internal temperature and air quality, improved fuel consumption, low emission, and smooth driving. The three fuzzy controllers include: (i) a fuzzy cruise controller to adapt vehicle cruise speed via prediction of the road ahead using a Look-Ahead system, (ii) a fuzzy air conditioning controller to produce desirable temperature and air quality inside vehicle cabin room via a road information system, and (iii) a fuzzy engine controller to generate the required engine torque to move the vehicle smoothly on the road. We optimised the integrated operation of the air conditioning and the engine under various driving patterns and performed three simulations. Results show that the proposed IEMC system developed based on Fuzzy Air Conditioning Controller with Look-Ahead (FAC-LA) method is a more efficient controller for vehicle air conditioning system than the previously developed Coordinated Energy Management Systems (CEMS). - Highlights: ► AC interacts: vehicle, environment, driver components, and the interrelationships between them. ► Intelligent AC algorithm which uses

Stem Cells in Tissue Repair and Regeneration

OpenAIRE

Falanga, Vincent

2012-01-01

The field of tissue repair and wound healing has blossomed in the last 30 years. We have gone from recombinant growth factors, to living tissue engineering constructs, to stem cells. The task now is to pursue true regeneration, thus achieving full restoration of structures and their function.

Perioperative management of endovascular abdominal aortic aneurysm repair

International Nuclear Information System (INIS)

Wang Haofu; Wang Yuwei; Li Jun; Zhao Zonggang; Qi Sen

2010-01-01

Objective: To summarize the clinical experience of perioperative management in performing endovascular abdominal aortic aneurysm repair (EVAR). Methods: EVAR was performed in 22 patients with abdominal aortic aneurysm. The clinical data were retrospectively analyzed. Before treatment the functions of main organs were evaluated and certain measures were adopted in order to protect them. Useful parameters, including the length, diameter, angle and configuration of the proximal and distal aneurysmal neck, the relationship of the aneurysm to aortic branches, the distance from the lowest renal artery to the bifurcation of abdominal aorta, and the quality of access vessels (such as diameter, tortuosity and calcification degree) were determined and assessed with CTA. According to the parameters thus obtained, the suitable stent-graft with ideal diameter and length was selected, and the optimal surgery pattern was employed. Local anesthesia was employed in 20 patients, among them the local anesthesia had to be changed to general anesthesia in one. Epidural anesthesia was carried out in one patient through the surgically-reconstructed iliac artery access,and general anesthesia was employed in one patient who had Stanford type A aortic dissection. The lowest renal artery must be accurately localized before deployment of stent-graft was started. At least one patent internal iliac artery should be reserved when bilateral internal iliac arteries needed to be covered, to be covered by stages or to be reconstructed. After stent-graft placement, angiography must be performed to find out if there was any endoleak and, if any, to determine the type of endoleak and to deal with it properly. Two cases had proximal type I endoleak, so balloon dilation was employed in one and cuff implantation in another one. Distal type I endoleak occurred in one case, but, unfortunately, the iliac artery ruptured when balloon dilation was employed, therefore the patient had to receive vascular repair

Engineering Center contribution to the Russian NPP aging management

International Nuclear Information System (INIS)

Bougaenko, S.

1993-01-01

The Engineering Center of strength, reliability and life of the nuclear equipment of the Minatom, Russia, has been set up by the decision of the management of the Russian Federation Ministry on the nuclear power (Russia Minatom) within the framework of the Research and Development Institute of Power Engineering (RDIPE). The Engineering Center is responsible for fulfilling the functions of the leading Institution of the Ministry concerning these issues and it is in charge of the development of the appropriate rules and standards package as well as their compliance with analogous international regulating documents. To put forward the national program on NPP aging management, and to implement it is one of the crucial tasks of the Engineering Center. This activity is conducted by both the cooperation between Russian Institution and experts and within the framework of the international collaboration. In the latter case it is worthy of noting the activity with respect to the American-Russian Working Group 12 ''NPP Aging and Life Extension'' and participation in appropriate programs of the IAEA. The major trends of the above activity are considered in this paper

Reservoir Engineering Management Program

Energy Technology Data Exchange (ETDEWEB)

Howard, J.H.; Schwarz, W.J.

1977-12-14

The Reservoir Engineering Management Program being conducted at Lawrence Berkeley Laboratory includes two major tasks: 1) the continuation of support to geothermal reservoir engineering related work, started under the NSF-RANN program and transferred to ERDA at the time of its formation; 2) the development and subsequent implementation of a broad plan for support of research in topics related to the exploitation of geothermal reservoirs. This plan is now known as the GREMP plan. Both the NSF-RANN legacies and GREMP are in direct support of the DOE/DGE mission in general and the goals of the Resource and Technology/Resource Exploitation and Assessment Branch in particular. These goals are to determine the magnitude and distribution of geothermal resources and reduce risk in their exploitation through improved understanding of generically different reservoir types. These goals are to be accomplished by: 1) the creation of a large data base about geothermal reservoirs, 2) improved tools and methods for gathering data on geothermal reservoirs, and 3) modeling of reservoirs and utilization options. The NSF legacies are more research and training oriented, and the GREMP is geared primarily to the practical development of the geothermal reservoirs. 2 tabs., 3 figs.

Reusable rocket engine preventive maintenance scheduling using genetic algorithm

International Nuclear Information System (INIS)

Chen, Tao; Li, Jiawen; Jin, Ping; Cai, Guobiao

2013-01-01

This paper deals with the preventive maintenance (PM) scheduling problem of reusable rocket engine (RRE), which is different from the ordinary repairable systems, by genetic algorithm. Three types of PM activities for RRE are considered and modeled by introducing the concept of effective age. The impacts of PM on all subsystems' aging processes are evaluated based on improvement factor model. Then the reliability of engine is formulated by considering the accumulated time effect. After that, optimization model subjected to reliability constraint is developed for RRE PM scheduling at fixed interval. The optimal PM combination is obtained by minimizing the total cost in the whole life cycle for a supposed engine. Numerical investigations indicate that the subsystem's intrinsic reliability characteristic and the improvement factor of maintain operations are the most important parameters in RRE's PM scheduling management

Knee Ligament Injury and the Clinical Application of Tissue Engineering Techniques: A Systematic Review.

Science.gov (United States)

Riley, Thomas C; Mafi, Reza; Mafi, Pouya; Khan, Wasim S

2018-02-23

The incidence of knee ligament injury is increasing and represents a significant cost to healthcare providers. Current interventions include tissue grafts, suture repair and non-surgical management. These techniques have demonstrated good patient outcomes but have been associated graft rejection, infection, long term immobilization and reduced joint function. The limitations of traditional management strategies have prompted research into tissue engineering of knee ligaments. This paper aims to evaluate whether tissue engineering of knee ligaments offers a viable alternative in the clinical management of knee ligament injuries. A search of existing literature was performed using OVID Medline, Embase, AMED, PubMed and Google Scholar, and a manual review of citations identified within these papers. Silk, polymer and extracellular matrix based scaffolds can all improve graft healing and collagen production. Fibroblasts and stem cells demonstrate compatibility with scaffolds, and have been shown to increase organized collagen production. These effects can be augmented using growth factors and extracellular matrix derivatives. Animal studies have shown tissue engineered ligaments can provide the biomechanical characteristics required for effective treatment of knee ligament injuries. There is a growing clinical demand for a tissue engineered alternative to traditional management strategies. Currently, there is limited consensus regarding material selection for use in tissue engineered ligaments. Further research is required to optimize tissue engineered ligament production before clinical application. Controlled clinical trials comparing the use of tissue engineered ligaments and traditional management in patients with knee ligament injury could determine whether they can provide a cost-effective alternative. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Co-engineering Participatory Water Management Processes: Theory and Insights from Australian and Bulgarian Interventions

Directory of Open Access Journals (Sweden)

Katherine A. Daniell

2010-12-01

Full Text Available Broad-scale, multi-governance level, participatory water management processes intended to aid collective decision making and learning are rarely initiated, designed, implemented, and managed by one person. These processes mostly emerge from some form of collective planning and organization activities because of the stakes, time, and budgets involved in their implementation. Despite the potential importance of these collective processes for managing complex water-related social-ecological systems, little research focusing on the project teams that design and organize participatory water management processes has ever been undertaken. We have begun to fill this gap by introducing and outlining the concept of a co-engineering process and examining how it impacts the processes and outcomes of participatory water management. We used a hybrid form of intervention research in two broad-scale, multi-governance level, participatory water management processes in Australia and Bulgaria to build insights into these co-engineering processes. We examined how divergent objectives and conflict in the project teams were negotiated, and the impacts of this co-engineering on the participatory water management processes. These investigations showed: (1 that language barriers may aid, rather than hinder, the process of stakeholder appropriation, collective learning and skills transferal related to the design and implementation of participatory water management processes; and (2 that diversity in co-engineering groups, if managed positively through collaborative work and integrative negotiations, can present opportunities and not just challenges for achieving a range of desired outcomes for participatory water management processes. A number of areas for future research on co-engineering participatory water management processes are also highlighted.

Bringing Knowledge Management into an Engineering Curriculum

Science.gov (United States)

Winberg, S. L.; Schach, S. R.; Inggs, M. R.

2007-01-01

The use of effective knowledge management is becoming an essential part of technical development projects in order to enable developers to handle the growing complexity of these projects. In this article we discuss an innovative approach to address this concern from the perspective of an undergraduate engineering curriculum. Instead of adding…

Bat Habitat Restoration and Management Opportunities on Corps of Engineers Projects

National Research Council Canada - National Science Library

2000-01-01

.... Although bats have not traditionally been addressed in Corps of Engineers planning and natural resources management efforts, the recent focus on ecosystem management and inclusion of nongame species...

Wet Weather Crater Repair Technologies for Grooved and Smooth Pavements

Science.gov (United States)

2018-04-30

Dean Geotechnical and Structures Laboratory U.S. Army Engineer Research and Development Center 3909 Halls Ferry Road Vicksburg, MS 39180-6199...ORGANIZATION REPORT NUMBER U.S. Army Engineer Research and Development Center Geotechnical and Structures Laboratory 3909 Halls Ferry Road ...SUBJECT TERMS Crater Concrete Rain and rainfall ADR Grooved pavement Smooth pavement Runoff Runways (Aeronautics) – Maintenance and repair

Management strategies, early results, benefits, and risk factors of laparoscopic repair of perforated peptic ulcer.

Science.gov (United States)

Lunevicius, Raimundas; Morkevicius, Matas

2005-10-01

The primary goal of this study was to describe epidemiology and management strategies of the perforated duodenal ulcer, as well as the most common methods of laparoscopic perforated duodenal ulcer repair. The secondary goal was to demonstrate the value of prospective and retrospective studies regarding the early results of surgery and the risk factors. The tertiary goal was to emphasize the benefits of this operation, and the fourth goal was to clarify the possible risk factors associated with laparoscopic repair of the duodenal ulcer. The Medline/Pubmed database was used. Review was done after evaluation of 96 retrieved full-text articles. Thirteen prospective and twelve retrospective studies were selected, grouped, and summarized. The spectrum of the retrospective studies' results are as follows: median overall morbidity rate 10.5 %, median conversion rate 7%, median hospital stay 7 days, and median postoperative mortality rate 0%. The following is the spectrum of results of the prospective studies: median overall morbidity rate was slightly less (6%); the median conversion rate was higher (15%); the median hospital stay was shorter (5 days) and the postoperative mortality was higher (3%). The risk factors identified were the same. Shock, delayed presentation (> 24 hours), confounding medical condition, age > 70 years, poor laparoscopic expertise, ASA III-IV, and Boey score should be considered preoperative laparoscopic repair risk factors. Each of these factors independently should qualify as a criterion for open repair due to higher intraoperative risks as well as postoperative morbidity. Inadequate ulcer localization, large perforation size (defined by some as > 6 mm diameter, and by others as > 10 mm), and ulcers with friable edges are also considered as conversion risk factors.

Model-Based Fault Management Engineering Tool Suite, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — NASA's successful development of next generation space vehicles, habitats, and robotic systems will rely on effective Fault Management Engineering. Our proposed...

Integrated Emission Management strategy for cost-optimal engine-aftertreatment operation

NARCIS (Netherlands)

Cloudt, R.P.M.; Willems, F.P.T.

2011-01-01

A new cost-based control strategy is presented that optimizes engine-aftertreatment performance under all operating conditions. This Integrated Emission Management strategy minimizes fuel consumption within the set emission limits by on-line adjustment of air management based on the actual state of

Establishment of Systematic Design Control/Configuration Management Processes to Enhance Engineering Capability

International Nuclear Information System (INIS)

Inagaki, T.; Hamada, T.; Ihara, T.

2016-01-01

Full text: After the accident of Fukushima Daiichi Nuclear Power Plant in 2011, Tokyo Electric Power Company (TEPCO) launched various measures to enhance plant safety and safety culture of its employees. One of the important aspects of these measures is to enhance engineering capability and TEPCO is conducting actions to establish systematic design control and configuration management processes as an important foundation of such engineering capability. This paper describes how TEPCO is establishing systematic configuration management processes from three aspects, i.e., design requirement and bases management, facility configuration control, and configuration change management. It also provides brief information of the IT systems that are being introduced and will support the systematic design control and configuration management processes. (author

Systems engineering management and implementation plan for Project W-464, immobilized high-level waste storage

International Nuclear Information System (INIS)

Wecks, M.D.

1998-01-01

The Systems Engineering Management and Implementation Plan (SEMIP) for TWRS Project W-46 describes the project implementation of the Tank Waste Remediation System Systems Engineering Management Plan. (TWRS SEMP), Rev. 1. The SEMIP outlines systems engineering (SE) products and processes to be used by the project for technical baseline development. A formal graded approach is used to determine the products necessary for requirements, design, and operational baseline completion. SE management processes are defined, and roles and responsibilities for management processes and major technical baseline elements are documented

Systems engineering management and implementation plan for Project W-465, immobilized low-activity waste storage

International Nuclear Information System (INIS)

Kaspar, J.R.; Latray, D.A.

1998-01-01

The Systems Engineering Management and Implementation Plan (SEMIP) for TWRS Project W-465 describes the project implementation of the Tank Waste Remediation System Systems Engineering Management Plan (TWRS SEMP), Rev. 1. The SEMIP outlines systems engineering (SE) products and processes to be used by the project for technical baseline development. A formal graded approach is used to determine the products necessary for requirements, design, and operational baseline completion. SE management processes are defined, and roles and responsibilities for management processes and major technical baseline elements are documented

Proceedings of 2011 International Conference on Electronic Engineering, Communication and Management

CERN Document Server

Lin, Sally

2012-01-01

This volume presents the main results of 2011 International Conference on Electronic  Engineering, Communication and Management (EECM2011) held December 24-25, 2011, Beijing China. The EECM2011 is an integrated conference providing a valuable opportunity for researchers, scholars and scientists to exchange their ideas face to face together. The main focus of the EECM 2011 and the present 2 volumes “Advances in Electronic Engineering, Communication and Management” is on Power Engineering, Electrical engineering applications, Electrical machines, as well as Communication and Information Systems Engineering.

Proceedings of 2011 International Conference on Electronic Engineering, Communication and Management

CERN Document Server

Lin, Sally

2012-01-01

  This volume presents the main results of 2011 International Conference on Electronic  Engineering, Communication and Management (EECM2011) held December 24-25, 2011, Beijing China. The EECM2011 is an integrated conference providing a valuable opportunity for researchers, scholars and scientists to exchange their ideas face to face together. The main focus of the EECM 2011 and the present 2 volumes “Advances in Electronic Engineering, Communication and Management” is on Power Engineering, Electrical engineering applications, Electrical machines, as well as Communication and Information Systems Engineering.

Optimization and translation of MSC-based hyaluronic acid hydrogels for cartilage repair

Science.gov (United States)

Erickson, Isaac E.

2011-12-01

Traumatic injury and disease disrupt the ability of cartilage to carry joint stresses and, without an innate regenerative response, often lead to degenerative changes towards the premature development of osteoarthritis. Surgical interventions have yet to restore long-term mechanical function. Towards this end, tissue engineering has been explored for the de novo formation of engineered cartilage as a biologic approach to cartilage repair. Research utilizing autologous chondrocytes has been promising, but clinical limitations in their yield have motivated research into the potential of mesenchymal stem cells (MSCs) as an alternative cell source. MSCs are multipotent cells that can differentiate towards a chondrocyte phenotype in a number of biomaterials, but no combination has successfully recapitulated the native mechanical function of healthy articular cartilage. The broad objective of this thesis was to establish an MSC-based tissue engineering approach worthy of clinical translation. Hydrogels are a common class of biomaterial used for cartilage tissue engineering and our initial work demonstrated the potential of a photo-polymerizable hyaluronic acid (HA) hydrogel to promote MSC chondrogenesis and improved construct maturation by optimizing macromer and MSC seeding density. The beneficial effects of dynamic compressive loading, high MSC density, and continuous mixing (orbital shaker) resulted in equilibrium modulus values over 1 MPa, well in range of native tissue. While compressive properties are crucial, clinical translation also demands that constructs stably integrate within a defect. We utilized a push-out testing modality to assess the in vitro integration of HA constructs within artificial cartilage defects. We established the necessity for in vitro pre-maturation of constructs before repair to achieve greater integration strength and compressive properties in situ. Combining high MSC density and gentle mixing resulted in integration strength over 500 k

3D printed microchannel networks to direct vascularisation during endochondral bone repair.

Science.gov (United States)

Daly, Andrew C; Pitacco, Pierluca; Nulty, Jessica; Cunniffe, Gráinne M; Kelly, Daniel J

2018-04-01

Bone tissue engineering strategies that recapitulate the developmental process of endochondral ossification offer a promising route to bone repair. Clinical translation of such endochondral tissue engineering strategies will require overcoming a number of challenges, including the engineering of large and often anatomically complex cartilage grafts, as well as the persistence of core regions of avascular cartilage following their implantation into large bone defects. Here 3D printing technology is utilized to develop a versatile and scalable approach to guide vascularisation during endochondral bone repair. First, a sacrificial pluronic ink was used to 3D print interconnected microchannel networks in a mesenchymal stem cell (MSC) laden gelatin-methacryloyl (GelMA) hydrogel. These constructs (with and without microchannels) were next chondrogenically primed in vitro and then implanted into critically sized femoral bone defects in rats. The solid and microchanneled cartilage templates enhanced bone repair compared to untreated controls, with the solid cartilage templates (without microchannels) supporting the highest levels of total bone formation. However, the inclusion of 3D printed microchannels was found to promote osteoclast/immune cell invasion, hydrogel degradation, and vascularisation following implantation. In addition, the endochondral bone tissue engineering strategy was found to support comparable levels of bone healing to BMP-2 delivery, whilst promoting lower levels of heterotopic bone formation, with the microchanneled templates supporting the lowest levels of heterotopic bone formation. Taken together, these results demonstrate that 3D printed hypertrophic cartilage grafts represent a promising approach for the repair of complex bone fractures, particularly for larger defects where vascularisation will be a key challenge. Copyright © 2018 Elsevier Ltd. All rights reserved.

The ATLAS Data Management Software Engineering Process

CERN Document Server

Lassnig, M; The ATLAS collaboration; Stewart, G A; Barisits, M; Beermann, T; Vigne, R; Serfon, C; Goossens, L; Nairz, A; Molfetas, A

2014-01-01

Rucio is the next-generation data management system of the ATLAS experiment. The software engineering process to develop Rucio is fundamentally different to existing software development approaches in the ATLAS distributed computing community. Based on a conceptual design document, development takes place using peer-reviewed code in a test-driven environment. The main objectives are to ensure that every engineer understands the details of the full project, even components usually not touched by them, that the design and architecture are coherent, that temporary contributors can be productive without delay, that programming mistakes are prevented before being committed to the source code, and that the source is always in a fully functioning state. This contribution will illustrate the workflows and products used, and demonstrate the typical development cycle of a component from inception to deployment within this software engineering process. Next to the technological advantages, this contribution will also hi...

The ATLAS Data Management Software Engineering Process

CERN Document Server

Lassnig, M; The ATLAS collaboration; Stewart, G A; Barisits, M; Beermann, T; Vigne, R; Serfon, C; Goossens, L; Nairz, A

2013-01-01

Rucio is the next-generation data management system of the ATLAS experiment. The software engineering process to develop Rucio is fundamentally different to existing software development approaches in the ATLAS distributed computing community. Based on a conceptual design document, development takes place using peer-reviewed code in a test-driven environment. The main objectives are to ensure that every engineer understands the details of the full project, even components usually not touched by them, that the design and architecture are coherent, that temporary contributors can be productive without delay, that programming mistakes are prevented before being committed to the source code, and that the source is always in a fully functioning state. This contribution will illustrate the workflows and products used, and demonstrate the typical development cycle of a component from inception to deployment within this software engineering process. Next to the technological advantages, this contribution will also hi...

Systems Engineering Management Plan for Tank Farm Restoration and Safety Operations, Project W-314

International Nuclear Information System (INIS)

MCGREW, D.L.

2000-01-01

The Systems Engineering Management Plan for Project W-314 has been prepared within the guidelines of HNF-SD-WM-SEMP-002, TWRS Systems Engineering Management Plan. The activities within this SEMP have been tailored, in accordance with the TWRS SEMP and DOE Order 430.1, Life Cycle Asset Management, to meet the needs of the project

Current Status of Tissue Engineering in the Management of Severe Hypospadias

Directory of Open Access Journals (Sweden)

Tariq O. Abbas

2018-01-01

Full Text Available Hypospadias, characterized by misplacement of the urinary meatus in the lower side of the penis, is a frequent birth defect in male children. Because of the huge variation in the anatomic presentation of hypospadias, no single urethroplasty procedure is suitable for all situations. Hence, many surgical techniques have emerged to address the shortage of tissues required to bridge the gap in the urethra particularly in the severe forms of hypospadias. However, the rate of postoperative complications of currently available surgical procedures reaches up to one-fourth of the patients having severe hypospadias. Moreover, these urethroplasty techniques are technically demanding and require considerable surgical experience. These limitations have fueled the development of novel tissue engineering techniques that aim to simplify the surgical procedures and to reduce the rate of complications. Several types of biomaterials have been considered for urethral repair, including synthetic and natural polymers, which in some cases have been seeded with cells prior to implantation. These methods have been tested in preclinical and clinical studies, with variable degrees of success. This review describes the different urethral tissue engineering methodologies, with focus on the approaches used for the treatment of hypospadias. At present, despite many significant advances, the search for a suitable tissue engineering approach for use in routine clinical applications continues.

Severe hepatic trauma: nonoperative management, definitive repair, or damage control surgery?

Science.gov (United States)

Leppäniemi, Ari K; Mentula, Panu J; Streng, Mari H; Koivikko, Mika P; Handolin, Lauri E

2011-12-01

Management of severe liver injuries has evolved to include the options for nonoperative management and damage control surgery. The present study analyzes the criteria for choosing between nonoperative management and early surgery, and definitive repair versus damage control strategy during early surgery. In a retrospective analysis of 144 patients with severe (AAST grade III-V) liver injuries (94% blunt trauma), early laparotomy was performed in 50 patients. Initial management was nonoperative in 94 blunt trauma patients with 8 failures. Uni- and multivariate analyses were used to calculate predictor odds ratios (OR) with 95% confidence intervals (CI). Factors associated with early laparotomy in blunt trauma included shock on admission, associated grade IV-V splenic injury, grade IV-V head injury, and grade V liver injury. Only shock was an independent predictor (OR, 26.1; 95% CI, 8.9-77.1; P < 0.001). The presence of a grade IV-V splenic injury predicted damage control strategy (OR infinite; P = 0.021). Failed nonoperative management was associated with grade IV-V splenic injury (OR, 14.00; 95% CI, 1.67-117.55), and shock (OR, 6.82; 95% CI, 1.49-31.29). The hospital mortality rate was 15%; 8 of 21 deaths were liver-related. Shock (OR, 9.3; 95% CI, 2.4-35.8; P = 0.001) and severe head injury (OR, 9.25; 95% CI, 3.0-28.9; P = 0.000) were independent predictors for mortality. In patients with severe liver injury, associated severe splenic injury favors early laparotomy and damage control strategy. Patients who arrive in shock or have an associated severe splenic injury should not be managed nonoperatively. In addition to severe head injury, uncontrollable bleeding from the liver injury is still a major cause of early death.

Space Station Freedom - Configuration management approach to supporting concurrent engineering and total quality management. [for NASA Space Station Freedom Program

Science.gov (United States)

Gavert, Raymond B.

1990-01-01

Some experiences of NASA configuration management in providing concurrent engineering support to the Space Station Freedom program for the achievement of life cycle benefits and total quality are discussed. Three change decision experiences involving tracing requirements and automated information systems of the electrical power system are described. The potential benefits of concurrent engineering and total quality management include improved operational effectiveness, reduced logistics and support requirements, prevention of schedule slippages, and life cycle cost savings. It is shown how configuration management can influence the benefits attained through disciplined approaches and innovations that compel consideration of all the technical elements of engineering and quality factors that apply to the program development, transition to operations and in operations. Configuration management experiences involving the Space Station program's tiered management structure, the work package contractors, international partners, and the participating NASA centers are discussed.

Injectable systems and implantable conduits for peripheral nerve repair

International Nuclear Information System (INIS)

Lin, Yen-Chih; Marra, Kacey G

2012-01-01

Acute sensory problems following peripheral nerve injury include pain and loss of sensation. Approximately 360 000 people in the United States suffer from upper extremity paralytic syndromes every year. Restoration of sufficient functional recovery after long-gap peripheral nerve damage remains a clinical challenge. Potential nerve repair therapies have increased in the past decade as the field of tissue engineering expands. The following review describes the use of biomaterials in nerve tissue engineering. Namely, the use of both synthetic and natural biomaterials, including non-degradable and degradable nerve grafts, is addressed. The enhancement of axonal regeneration can be achieved by further modification of the nerve guides. These approaches include injectable hydrogel fillers, controlled drug delivery systems, and cell incorporation. Hydrogels are a class of liquid–gel biomaterials with high water content. Injectable and gelling hydrogels can serve as growth factor delivery vehicles and cell carriers for tissue engineering applications. While natural hydrogels and polymers are suitable for short gap nerve repair, the use of polymers for relatively long gaps remains a clinical challenge. (paper)

Three-Dimensional Printing and Cell Therapy for Wound Repair.

Science.gov (United States)

van Kogelenberg, Sylvia; Yue, Zhilian; Dinoro, Jeremy N; Baker, Christopher S; Wallace, Gordon G

2018-05-01

Significance: Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach to regenerative medicine, whereby cells and cell-based materials can be dispensed in fine spatial arrangements to mimic native tissue. Recent Advances: Various bioprinting techniques have been employed in wound repair-based skin tissue engineering, from laser-induced forward transfer to extrusion-based methods, and with the investigation of the benefits and shortcomings of each, with emphasis on biological compatibility and cell proliferation, migration, and vitality. Critical issues: Development of appropriate biological inks and the vascularization of newly developed tissues remain a challenge within the field of skin tissue engineering. Future Directions: Progress within bioprinting requires close interactions between material scientists, tissue engineers, and clinicians. Microvascularization, integration of multiple cell types, and skin appendages will be essential for creation of complex skin tissue constructs.

Sustainable water management under future uncertainty with eco-engineering decision scaling

Science.gov (United States)

Poff, N. Leroy; Brown, Casey M.; Grantham, Theodore E.; Matthews, John H.; Palmer, Margaret A.; Spence, Caitlin M.; Wilby, Robert L.; Haasnoot, Marjolijn; Mendoza, Guillermo F.; Dominique, Kathleen C.; Baeza, Andres

2016-01-01

Managing freshwater resources sustainably under future climatic and hydrological uncertainty poses novel challenges. Rehabilitation of ageing infrastructure and construction of new dams are widely viewed as solutions to diminish climate risk, but attaining the broad goal of freshwater sustainability will require expansion of the prevailing water resources management paradigm beyond narrow economic criteria to include socially valued ecosystem functions and services. We introduce a new decision framework, eco-engineering decision scaling (EEDS), that explicitly and quantitatively explores trade-offs in stakeholder-defined engineering and ecological performance metrics across a range of possible management actions under unknown future hydrological and climate states. We illustrate its potential application through a hypothetical case study of the Iowa River, USA. EEDS holds promise as a powerful framework for operationalizing freshwater sustainability under future hydrological uncertainty by fostering collaboration across historically conflicting perspectives of water resource engineering and river conservation ecology to design and operate water infrastructure for social and environmental benefits.

Sustainable water management under future uncertainty with eco-engineering decision scaling

Science.gov (United States)

Poff, N LeRoy; Brown, Casey M; Grantham, Theodore E.; Matthews, John H; Palmer, Margaret A.; Spence, Caitlin M; Wilby, Robert L.; Haasnoot, Marjolijn; Mendoza, Guillermo F; Dominique, Kathleen C; Baeza, Andres

2015-01-01

Managing freshwater resources sustainably under future climatic and hydrological uncertainty poses novel challenges. Rehabilitation of ageing infrastructure and construction of new dams are widely viewed as solutions to diminish climate risk, but attaining the broad goal of freshwater sustainability will require expansion of the prevailing water resources management paradigm beyond narrow economic criteria to include socially valued ecosystem functions and services. We introduce a new decision framework, eco-engineering decision scaling (EEDS), that explicitly and quantitatively explores trade-offs in stakeholder-defined engineering and ecological performance metrics across a range of possible management actions under unknown future hydrological and climate states. We illustrate its potential application through a hypothetical case study of the Iowa River, USA. EEDS holds promise as a powerful framework for operationalizing freshwater sustainability under future hydrological uncertainty by fostering collaboration across historically conflicting perspectives of water resource engineering and river conservation ecology to design and operate water infrastructure for social and environmental benefits.

Scenario logic and probabilistic management of risk in business and engineering

CERN Document Server

Solojentsev, Evgueni D

2009-01-01

The book proposes a uniform logic and probabilistic (LP) approach to risk estimation and analysis in engineering and economics. It covers the methodological and theoretical basis of risk management at the design, test, and operation stages of economic, banking, and engineering systems with groups of incompatible events (GIE). It considers the risk LP-models in classification, investment, management of companies, bribes and corruption, analysis of risk and efficiency of social and economical processes, and management of development. Key features of this Second Edition: -Five new chapters -Treatment of the basic principles of the modern risk LP theory (the LP-calculus, the LP-methods and the risk LP-theory with GIE) using uniform methodology and terminology with a practical orientation towards both engineering and economics, for the first time in book form -Clear definitions and notations, revised sections and chapters, an extended list of references, and a new subject index -More than a hundred illustrations a...

Structure and Management of an Engineering Senior Design Course.

Science.gov (United States)

Tanaka, Martin L; Fischer, Kenneth J

2016-07-01

The design of products and processes is an important area in engineering. Students in engineering schools learn fundamental principles in their courses but often lack an opportunity to apply these methods to real-world problems until their senior year. This article describes important elements that should be incorporated into a senior capstone design course. It includes a description of the general principles used in engineering design and a discussion of why students often have difficulty with application and revert to trial and error methods. The structure of a properly designed capstone course is dissected and its individual components are evaluated. Major components include assessing resources, identifying projects, establishing teams, understanding requirements, developing conceptual designs, creating detailed designs, building prototypes, testing performance, and final presentations. In addition to the course design, team management and effective mentoring are critical to success. This article includes suggested guidelines and tips for effective design team leadership, attention to detail, investment of time, and managing project scope. Furthermore, the importance of understanding business culture, displaying professionalism, and considerations of different types of senior projects is discussed. Through a well-designed course and proper mentoring, students will learn to apply their engineering skills and gain basic business knowledge that will prepare them for entry-level positions in industry.

Advanced Strategies for Articular Cartilage Defect Repair

Directory of Open Access Journals (Sweden)

Fergal J. O'Brien

2013-02-01

Full Text Available Articular cartilage is a unique tissue owing to its ability to withstand repetitive compressive stress throughout an individual’s lifetime. However, its major limitation is the inability to heal even the most minor injuries. There still remains an inherent lack of strategies that stimulate hyaline-like articular cartilage growth with appropriate functional properties. Recent scientific advances in tissue engineering have made significant steps towards development of constructs for articular cartilage repair. In particular, research has shown the potential of biomaterial physico-chemical properties significantly influencing the proliferation, differentiation and matrix deposition by progenitor cells. Accordingly, this highlights the potential of using such properties to direct the lineage towards which such cells follow. Moreover, the use of soluble growth factors to enhance the bioactivity and regenerative capacity of biomaterials has recently been adopted by researchers in the field of tissue engineering. In addition, gene therapy is a growing area that has found noteworthy use in tissue engineering partly due to the potential to overcome some drawbacks associated with current growth factor delivery systems. In this context, such advanced strategies in biomaterial science, cell-based and growth factor-based therapies that have been employed in the restoration and repair of damaged articular cartilage will be the focus of this review article.

Emerging issues in peripheral nerve repair

Institute of Scientific and Technical Information of China (English)

Stefano Geuna; Pierluigi Tos; Bruno Battiston

2012-01-01

It is today widely acknowledged that nerve repair is now more than a matter of perfect microsurgical reconstruction only and that,to further improve clinical outcome,the involvement of different scientific disciplines is required.This evolving reconstructive/regenerative approach is based on the interdisciplinary and integrated pillars of tissue engineering such as reconstructive microsurgery,transplantation and biomaterials.In this paper,some of the most promising innovations for the tissue engineering of nerves,emerging from basic science investigation,are critically overviewed with special focus on those approaches that appear today to be more suitable for clinical translation.

Osteogenesis and angiogenesis: The potential for engineering bone

Directory of Open Access Journals (Sweden)

JM Kanczler

2008-05-01

Full Text Available The repair of large bone defects remains a major clinical orthopaedic challenge. Bone is a highly vascularised tissue reliant on the close spatial and temporal connection between blood vessels and bone cells to maintain skeletal integrity. Angiogenesis thus plays a pivotal role in skeletal development and bone fracture repair. Current procedures to repair bone defects and to provide structural and mechanical support include the use of grafts (autologous, allogeneic or implants (polymeric or metallic. These approaches face significant limitations due to insufficient supply, potential disease transmission, rejection, cost and the inability to integrate with the surrounding host tissue.The engineering of bone tissue offers new therapeutic strategies to aid musculoskeletal healing. Various scaffold constructs have been employed in the development of tissue-engineered bone; however, an active blood vessel network is an essential pre-requisite for these to survive and integrate with existing host tissue. Combination therapies of stem cells and polymeric growth factor release scaffolds tailored to promote angiogenesis and osteogenesis are under evaluation and development actively to stimulate bone regeneration. An understanding of the cellular and molecular interactions of blood vessels and bone cells will enhance and aid the successful development of future vascularised bone scaffold constructs, enabling survival and integration of bioengineered bone with the host tissue. The role of angiogenic and osteogenic factors in the adaptive response and interaction of osteoblasts and endothelial cells during the multi step process of bone development and repair will be highlighted in this review, with consideration of how some of these key mechanisms can be combined with new developments in tissue engineering to enable repair and growth of skeletal fractures. Elucidation of the processes of angiogenesis, osteogenesis and tissue engineering strategies offer

Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction

OpenAIRE

Yates, E. W.; Rupani, A.; Foley, G. T.; Khan, W. S.; Cartmell, S.; Anand, S. J.

2011-01-01

Tissue engineering is an emerging discipline that combines the principle of science and engineering. It offers an unlimited source of natural tissue substitutes and by using appropriate cells, biomimetic scaffolds, and advanced bioreactors, it is possible that tissue engineering could be implemented in the repair and regeneration of tissue such as bone, cartilage, tendon, and ligament. Whilst repair and regeneration of ligament tissue has been demonstrated in animal studies, further research ...

Component-Level Electronic-Assembly Repair (CLEAR) System Architecture

Science.gov (United States)

Oeftering, Richard C.; Bradish, Martin A.; Juergens, Jeffrey R.; Lewis, Michael J.; Vrnak, Daniel R.

2011-01-01

This document captures the system architecture for a Component-Level Electronic-Assembly Repair (CLEAR) capability needed for electronics maintenance and repair of the Constellation Program (CxP). CLEAR is intended to improve flight system supportability and reduce the mass of spares required to maintain the electronics of human rated spacecraft on long duration missions. By necessity it allows the crew to make repairs that would otherwise be performed by Earth based repair depots. Because of practical knowledge and skill limitations of small spaceflight crews they must be augmented by Earth based support crews and automated repair equipment. This system architecture covers the complete system from ground-user to flight hardware and flight crew and defines an Earth segment and a Space segment. The Earth Segment involves database management, operational planning, and remote equipment programming and validation processes. The Space Segment involves the automated diagnostic, test and repair equipment required for a complete repair process. This document defines three major subsystems including, tele-operations that links the flight hardware to ground support, highly reconfigurable diagnostics and test instruments, and a CLEAR Repair Apparatus that automates the physical repair process.

Information Management in Creative Engineering Design and Capabilities of Database Transactions

DEFF Research Database (Denmark)

Jacobsen, Kim; Eastman, C. A.; Jeng, T. S.

1997-01-01

This paper examines the information management requirements and sets forth the general criteria for collaboration and concurrency control in creative engineering design. Our work attempts to recognize the full range of concurrency, collaboration and complex transactions structure now practiced...... in manual and semi-automated design and the range of capabilities needed as the demands for enhanced but flexible electronic information management unfolds.The objective of this paper is to identify new issues that may advance the use of databases to support creative engineering design. We start...... with a generalized description of the structure of design tasks and how information management in design is dealt with today. After this review, we identify extensions to current information management capabilities that have been realized and/or proposed to support/augment what designers can do now. Given...

11th International Conference on Software Engineering Research, Management and Applications

CERN Document Server

2014-01-01

The purpose of the 11th International Conference on Software Engineering Research, Management and Applications (SERA 2013) held on August 7 - 9, 2012 in Prague, Czech Republic was to bring together scientists, engineers, computer users, and students to share their experiences and exchange new ideas and research results about all aspects (theory, applications and tools) of Software Engineering Research, Management and Applications, and to discuss the practical challenges encountered along the way and the solutions adopted to solve them.   The conference organizers selected 17 outstanding papers from those papers accepted for presentation at the conference in order to publish them in this volume.  The papers were chosen based on review scores submitted by members of the program committee, and further rigorous rounds of review.

Perspectives of genetic engineering in radiobiology

International Nuclear Information System (INIS)

Khanson, K.P.; Zvonareva, N.B.; Evtushenko, V.I.

1988-01-01

Present evidence on the use of genetic engineering methods in studying the molecular mechanism of radiation damage and repair of DNA, as well as radiation mutagenesis and carcinogenesis has been summarized. The new approach to radiobiological research has proved to be extremely fruitful. Some previously unknown types of structural disorders in DNA molecule have been discovered, some repair genes isolated and their primary structure established, some aspects of radiation mutagenesis elucidated, and research into disiphering the molecular bases of neoplastic transformations of exposed cells are being successfully investigated. The perspectives of using genetic engineering methods in radiobiology are discussed

The ATLAS data management software engineering process

International Nuclear Information System (INIS)

Lassnig, M; Garonne, V; Stewart, G A; Barisits, M; Serfon, C; Goossens, L; Nairz, A; Beermann, T; Vigne, R; Molfetas, A

2014-01-01

Rucio is the next-generation data management system of the ATLAS experiment. The software engineering process to develop Rucio is fundamentally different to existing software development approaches in the ATLAS distributed computing community. Based on a conceptual design document, development takes place using peer-reviewed code in a test-driven environment. The main objectives are to ensure that every engineer understands the details of the full project, even components usually not touched by them, that the design and architecture are coherent, that temporary contributors can be productive without delay, that programming mistakes are prevented before being committed to the source code, and that the source is always in a fully functioning state. This contribution will illustrate the workflows and products used, and demonstrate the typical development cycle of a component from inception to deployment within this software engineering process. Next to the technological advantages, this contribution will also highlight the social aspects of an environment where every action is subject to detailed scrutiny.

The ATLAS data management software engineering process

Science.gov (United States)

Lassnig, M.; Garonne, V.; Stewart, G. A.; Barisits, M.; Beermann, T.; Vigne, R.; Serfon, C.; Goossens, L.; Nairz, A.; Molfetas, A.; Atlas Collaboration

2014-06-01

Rucio is the next-generation data management system of the ATLAS experiment. The software engineering process to develop Rucio is fundamentally different to existing software development approaches in the ATLAS distributed computing community. Based on a conceptual design document, development takes place using peer-reviewed code in a test-driven environment. The main objectives are to ensure that every engineer understands the details of the full project, even components usually not touched by them, that the design and architecture are coherent, that temporary contributors can be productive without delay, that programming mistakes are prevented before being committed to the source code, and that the source is always in a fully functioning state. This contribution will illustrate the workflows and products used, and demonstrate the typical development cycle of a component from inception to deployment within this software engineering process. Next to the technological advantages, this contribution will also highlight the social aspects of an environment where every action is subject to detailed scrutiny.

An evaluation of Admedus' tissue engineering process-treated (ADAPT) bovine pericardium patch (CardioCel) for the repair of cardiac and vascular defects.

Science.gov (United States)

Strange, Geoff; Brizard, Christian; Karl, Tom R; Neethling, Leon

2015-03-01

Tissue engineers have been seeking the 'Holy Grail' solution to calcification and cytotoxicity of implanted tissue for decades. Tissues with all of the desired qualities for surgical repair of congenital heart disease (CHD) are lacking. An anti-calcification tissue engineering process (ADAPT TEP) has been developed and applied to bovine pericardium (BP) tissue (CardioCel, AdmedusRegen Pty Ltd, Perth, WA, Australia) to eliminate cytotoxicity, improve resistance to acute and chronic inflammation, reduce calcification and facilitate controlled tissue remodeling. Clinical data in pediatric patients, and additional pre-market authorized prescriber data demonstrate that CardioCel performs extremely well in the short term and is safe and effective for a range of congenital heart deformations. These data are supported by animal studies which have shown no more than normal physiologic levels of calcification, with good durability, biocompatibility and controlled healing.

A Web portal for the Engineering and Equipment Data Management System at CERN

International Nuclear Information System (INIS)

Tsyganov, A; Petit, S; Martel, P; Milenkovic, S; Suwalska, A; Delamare, C; Widegren, D; Amerigo, S Mallon; Pettersson, T

2010-01-01

CERN, the European Laboratory for Particle Physics, located in Geneva - Switzerland, has recently started the Large Hadron Collider (LHC), a 27 km particle accelerator. The CERN Engineering and Equipment Data Management Service (EDMS) provides support for managing engineering and equipment information throughout the entire lifecycle of a project. Based on several both in-house developed and commercial data management systems, this service supports management and follow-up of different kinds of information throughout the lifecycle of the LHC project: design, manufacturing, installation, commissioning data, maintenance and more. The data collection phase, carried out by specialists, is now being replaced by a phase during which data will be consulted on an extensive basis by non-experts users. In order to address this change, a Web portal for the EDMS has been developed. It brings together in one space all the aspects covered by the EDMS: project and document management, asset tracking and safety follow-up. This paper presents the EDMS Web portal, its dynamic content management and its 'one click' information search engine.

412th Test Engineering Group Vision for Future Knowledge Management (KM)

Science.gov (United States)

2018-05-17

Presentation 3. DATES COVERED (From - To) 17 May 2018 4. TITLE AND SUBTITLE 412th Test Engineering Group Vision for Future Knowledge Management (KM... Engineering Group 307 E. Popson Ave Edwards AFB, CA 93523 8. PERFORMING ORGANIZATION REPORT NUMBER 412TW-PA...centers for the TENG test customers to allow the data to be readily available within minutes of a flight, for the data to be organized so that the engineer

Additive Manufacturing in Offsite Repair of Consumer Electronics

Science.gov (United States)

Chekurov, Sergei; Salmi, Mika

Spare parts for products that are at the end of their life cycles, but still under warranty, are logistically difficult because they are commonly not stored in the central warehouse. These uncommon spare parts occupy valuable space in smaller inventories and take a long time to be transported to the point of need, thus delaying the repair process. This paper proposes that storing the spare parts on a server and producing them with additive manufacturing (AM) on demand can shorten the repair cycle by simplifying the logistics. Introducing AM in the repair supply chain lowers the number of products that need to be reimbursed to the customer due to lengthy repairs, improves the repair statistics of the repair shops, and reduces the number of items that are held in stock. For this paper, the functionality of the concept was verified by reverse engineering a memory cover of a portable computer and laser sintering it from polyamide 12. The additively manufactured component fit well and the computer operated normally after the replacement. The current spare part supply chain model and models with AM machinery located at the repair shop, the centralized spare part provider, and the original equipment manufacturer were provided. The durations of the repair process in the models were compared by simulating two scenarios with the Monte Carlo method. As the biggest improvement, the model with the AM machine in the repair shop reduced the duration of the repair process from 14 days to three days. The result points to the conclusion that placing the machine as close to the need as possible is the best option, if there is enough demand. The spare parts currently compatible with AM are plastic components without strict surface roughness requirements, but more spare parts will become compatible with the development of AM.

The future of the Canadian oil sands: Engineering and project management advances

Energy Technology Data Exchange (ETDEWEB)

Madden, Peter; Morawski, Jacek

2010-09-15

Production technology and project management developments in Canada's oil sands industry, in the context of AMEC's experience as EPCM service provider, are discussed. Effective project management systems and workfront planning are critical to achieve cost and schedule targets and optimum construction execution. Construction Work Packages divide work into discrete pieces and Construction Work Execution Plans influence scheduling of engineering and procurement deliverables. AMEC's Engineering Data Warehouse works with intelligent engineering design tools to ensure information related to a piece of equipment is consistent across all systems. HSSE systems are proactively developed and AMEC's progressive improvement in safety performance is demonstrated.

Managing the continuum certainty, uncertainty, unpredictability in large engineering projects

CERN Document Server

Caron, Franco

2013-01-01

The brief will describe how to develop a risk analysis applied to a project , through a sequence of steps: risk management planning, risk identification, risk classification, risk assessment, risk quantification, risk response planning, risk monitoring and control, process close out and lessons learning. The project risk analysis and management process will be applied to large engineering projects, in particular related to the oil and gas industry. The brief will address the overall range of possible events affecting the project moving from certainty (project issues) through uncertainty (project risks) to unpredictability (unforeseeable events), considering both negative and positive events. Some quantitative techniques (simulation, event tree, Bayesian inference, etc.) will be used to develop risk quantification. The brief addresses a typical subject in the area of project management, with reference to large engineering projects concerning the realization of large plants and infrastructures. These projects a...

Development of the environmental management integrated baseline at the Idaho National Engineering Laboratory using systems engineering

International Nuclear Information System (INIS)

Murphy, J.A.; Caliva, R.M.; Wixson, J.R.

1997-01-01

The Idaho National Engineering Laboratory (INEL) is one of many Department of Energy (DOE) national laboratories that has been performing environmental cleanup and stabilization, which was accelerated upon the end of the cold war. In fact, the INEL currently receives two-thirds of its scope to perform these functions. However, the cleanup is a highly interactive system that creates an opportunity for systems engineering methodology to be employed. At the INEL, a group called EM (Environmental Management) Integration has been given this charter along with a small core of systems engineers. This paper discusses the progress to date of converting the INEL legacy system into one that uses the systems engineering discipline as the method to ensure that external requirements are met

Very High Frequency Monitoring System for Engine Gearbox and Generator Health Management (Postprint)

National Research Council Canada - National Science Library

Watson, Matthew J; Byington, Carl S; Behbahani, Alireza

2007-01-01

.... These gas turbine engine vibration monitoring technologies will address existing operation and maintenance goals for current military system and prognostics health management algorithms for advanced engines...

Mitral valve repair: an echocardiographic review: Part 2.

Science.gov (United States)

Maslow, Andrew

2015-04-01

Echocardiographic imaging of the mitral valve before and immediately after repair is crucial to the immediate and long-term outcome. Prior to mitral valve repair, echocardiographic imaging helps determine the feasibility and method of repair. After the repair, echocardiographic imaging displays the new baseline anatomy, assesses function, and determines whether or not further management is necessary. Three-dimensional imaging has improved the assessment of the mitral valve and facilitates communication with the surgeon by providing the surgeon with an image that he/she might see upon opening up the atrium. Further advancements in imaging will continue to improve the understanding of the function and dysfunction of the mitral valve both before and after repair. This information will improve treatment options, timing of invasive therapies, and advancements of repair techniques to yield better short- and long-term patient outcomes. The purpose of this review was to connect the echocardiographic evaluation with the surgical procedure. Bridging the pre- and post-CPB imaging with the surgical procedure allows a greater understanding of mitral valve repair.

Safety of repair for severe duodenal injuries.

Science.gov (United States)

Velmahos, George C; Constantinou, Constantinos; Kasotakis, George

2008-01-01

There is ongoing debate about the management of severe duodenal injuries (SDIs), and earlier studies have recommended pyloric exclusion. The objective of this study was to compare primary repair with pyloric exclusion to examine if primary repair can be safely used in SDIs. The medical records of 193 consecutive patients who were admitted between August 1992 and January 2004 with duodenal injuries were reviewed. After excluding early deaths (n = 50), low-grade duodenal injuries (n = 81), and pancreatoduodenectomies for catastrophic trauma (n = 12), a total of 50 patients with SDIs (grade III, IV, or V) were analyzed. Primary repair (PR--simple duodenorrhaphy or resection and primary anastomosis) was performed in 34 (68%) and pyloric exclusion (PE) in 16 (32%). Characteristics and outcomes of these two groups were compared. PE and PR patients were similar for age, injury severity score, abdominal abbreviated injury score, physiologic status on admission, time to operation, and most abdominal organs injured. PE patients had more pancreatic injuries (63% vs. 24%, p duodenum (79% vs. 42%, p = 0.02), and a nonsignificant trend toward more grade IV and V injuries (37% vs. 18%, p = 0.11). There was no difference in morbidity (including complications specific to the duodenal repair), mortality, and intensive care unit and hospital length of stay between the two groups. Pyloric exclusion is not necessary for all patients with SDIs, as previously suggested. Selected SDI patients can be safely managed by simple primary repair.

Fundamentals of bladder tissue engineering | Mahfouz | African ...

African Journals Online (AJOL)

Fundamentals of bladder tissue engineering. ... could affect the bladder and lead to eventual loss of its integrity, with the need for replacement or repair. ... Tissue engineering relies upon three essential pillars; the scaffold, the cells seeded on ...

MICADO The data import engine of the CERN engineering and equipment data management system

CERN Document Server

Widegren, David; Lyzwa, R; Mallon Amerigo, S; Petit, S; Rousseau, B

2008-01-01

The CERN Engineering and Equipment Data Management System (EDMS) is one of the largest and most complex data management systems of its kind. For the last 10 years, it has received huge quantities of data generated in the different LHC project phases. Capturing all this information would not have been possible without a robust, failsafe, yet flexible and user-friendly data import engine. For this purpose the Micado toolkit was developed at CERN using XML standards, providing multi-level data verifications, an advanced queuing mechanism and batch processing of large amounts of import requests. Whereas Micado originally was developed to facilitate the capturing of LHC manufacturing data, its modular architecture has allowed a cost-effective extension to also cater for the LHC installation and hardware commissioning data import processes. Recently Micado has broadened its scope even further, including also imports of safety inspections, and at the same time the next generation of the tool providing Web Services i...

"Poverty is the big thing": exploring financial, transportation, and opportunity costs associated with fistula management and repair in Nigeria and Uganda.

Science.gov (United States)

Keya, Kaji Tamanna; Sripad, Pooja; Nwala, Emmanuel; Warren, Charlotte E

2018-06-01

Women living with obstetric fistula often live in poverty and in remote areas far from hospitals offering surgical repair. These women and their families face a range of costs while accessing fistula repair, some of which include: management of their condition, lost productivity and time, and transport to facilities. This study explores, through women's, communities', and providers' perspectives, the financial, transport, and opportunity cost barriers and enabling factors for seeking repair services. A qualitative approach was applied in Kano and Ebonyi in Nigeria and Hoima and Masaka in Uganda. Between June and December 2015, the study team conducted in-depth interviews (IDIs) with women affected by fistula (n = 52) - including those awaiting repair, living with fistula, and after repair, and their spouses and other family members (n = 17), along with health service providers involved in fistula repair and counseling (n = 38). Focus group discussions (FGDs) with male and female community stakeholders (n = 8) and post-repair clients (n = 6) were also conducted. Women's experiences indicate the obstetric fistula results in a combined set of costs associated with delivery, repair, transportation, lost income, and companion expenses that are often limiting. Medical and non-medical ancillary costs such as food, medications, and water are not borne evenly among all fistula care centers or camps due to funding shortages. In Uganda, experienced transport costs indicate that women spend Ugandan Shilling (UGX) 10,000 to 90,000 (US$3.00-US$25.00) for two people for a single trip to a camp (client and her caregiver), while Nigerian women (Kano) spent Naira 250 to 2000 (US$0.80-US$6.41) for transportation. Factors that influence women's and families' ability to cover costs of fistula care access include education and vocational skills, community savings mechanisms, available resources in repair centers, client counseling, and subsidized care and

Single-Molecule Methods for Nucleotide Excision Repair: Building a System to Watch Repair in Real Time.

Science.gov (United States)

Kong, Muwen; Beckwitt, Emily C; Springall, Luke; Kad, Neil M; Van Houten, Bennett

2017-01-01

Single-molecule approaches to solving biophysical problems are powerful tools that allow static and dynamic real-time observations of specific molecular interactions of interest in the absence of ensemble-averaging effects. Here, we provide detailed protocols for building an experimental system that employs atomic force microscopy and a single-molecule DNA tightrope assay based on oblique angle illumination fluorescence microscopy. Together with approaches for engineering site-specific lesions into DNA substrates, these complementary biophysical techniques are well suited for investigating protein-DNA interactions that involve target-specific DNA-binding proteins, such as those engaged in a variety of DNA repair pathways. In this chapter, we demonstrate the utility of the platform by applying these techniques in the studies of proteins participating in nucleotide excision repair. © 2017 Elsevier Inc. All rights reserved.

An Exploration of the Professional Competencies Required in Engineering Asset Management

Science.gov (United States)

Bish, Adelle J.; Newton, Cameron J.; Browning, Vicky; O'Connor, Peter; Anibaldi, Renata

2014-01-01

Engineering asset management (EAM) is a rapidly growing and developing field. However, efforts to select and develop engineers in this area are complicated by our lack of understanding of the full range of competencies required to perform. This exploratory study sought to clarify and categorise the professional competencies required of individuals…

COLOSTRUM-COLLAGEN-HYDROXYAPATITE COMPOSITE, AN EXCELLENT CANDIDATE BIOMATERIAL FOR BONE REPAIR AND BONE INFECTION MANAGEMENT

Directory of Open Access Journals (Sweden)

Dio Nurdin Setiawan

2014-05-01

Full Text Available In the case ofbone fracture or defect after surgery, which is common in patients with bone cancer (osteosarcoma, it takes a long time for closure and it may cause an infection problem. The use ofcollagen-hydroxyapatite composite with a blend ofcolostrum as a scaffold is aimed to accelerate the process of osteoblast growth, inhibite the emergence of infections, and act as bone tissue repair material. The method used was the hydrogel formation process and freeze dry process to remove the solvent and to form pores. The composition of scaffold composite manufactured was 15% collagen, 75% hydroxyapatite and 10% colostrum. Combination ofscaffold collagen-hydroxyapatite-colostrum has quite reliable properties because SEM test showed that scaffold could bind to both and could bind to both and could form sufficient pores to provide enough place for bone cells (osteoblats to grow. The results of MTT assay revealed percentage of above 60%, which indicates that the material is not toxic. In conclusion, collagen-hydroxyapatite-colostrum combination is an excellent biomaterial candidate for bone repair and bone infection management.

Developing a Model for Optimizing Inventory of Repairable Items at Single Operating Base

OpenAIRE

Le, Tin

2016-01-01

The use of EOQ model in inventory management is popular. However, EOQ models has many disadvantages, especially, when the model is applied to manage repairable items. In order to deal with high-cost and repairable items, Craig C. Sherbrooke introduced a model in his book “Optimal Inventory Modeling of Systems: Multi-Echelon Techniques”. The research focus is to implement and develop a program to execute the single-site in-ventory model for repairable items. The model helps to significantl...

Performance of patch repaired composite panels under fatigue loads

International Nuclear Information System (INIS)

Darwish, Feras H.; Hamoush, S.; Shivakumar, K.

2006-01-01

This paper evaluates the performance of bonded patch-scarf repairs of full scale laminated composite panels under cyclic load conditions. Nondestructive testing to characterize the quality of repairs and destructive testing to evaluate the performance of repaired panels were used in this study. Carbon/Epoxy prepreg material used was used to lay up six-ply (12 in. x 27 in. /305x686mm) (-60/60/0) s quasi-isotropic laminates. 7-ply scarf repair with a gradient of 0.5 inch (12.7mm) per layer was used to perform the repair of a damaged zone. The patch consisted of 7.5 inches (190mm) diameter adhesive film, 1 inch (25.4mm) diameter filler ply at 90fiber orientation, and six plies (2-7 inches (51-178mm) diameter) to match the lay-up of the parent material. The study was extended to include defective repairs. The defect was engineered by inserting a 1 inch (25.4 mm) circular Teflon flaw between the fifth and sixth layers of the patch. A total of 28 panels were prepared and divided into five categories: (1) three pristine panels (undamaged parental materials); (2) three damaged panels (1-inch-centered-hole); (3) two repaired panels with wrong fiber orientation; (4) nine good repaired panels, and (5) eleven defective repair panels (1 inch flaw). A nondestructive evaluation to check the conditions of the repairs was performed on most of the tested panels that include the pulse-echo C-scan and pseudo through transmission air coupled and water coupled C-scan. Based on the results of the experimental evaluation of this study, good repair restored 95% of the tensile strength while defective repair restored 90% of the tensile strength of the pristine panels. Under fatigue loading, panels repaired with a 1 inch delamination flaw within the patch layers showed a major reduction in fatigue life compared to the good repair panels under similar loading conditions. (author)

76 FR 13666 - Pitney Bowes, Inc., Mailing Solutions Management, Global Engineering Group, Including On-Site...

Science.gov (United States)

2011-03-14

...., Mailing Solutions Management, Global Engineering Group, Including On-Site Leased Workers From Guidant... workers and former workers of Pitney Bowes, Inc., Mailing Solutions Management Division, Engineering... reviewed the certification to clarify the subject worker group's identity. Additional information revealed...

Genetic engineering for skeletal regenerative medicine.

Science.gov (United States)

Gersbach, Charles A; Phillips, Jennifer E; García, Andrés J

2007-01-01

The clinical challenges of skeletal regenerative medicine have motivated significant advances in cellular and tissue engineering in recent years. In particular, advances in molecular biology have provided the tools necessary for the design of gene-based strategies for skeletal tissue repair. Consequently, genetic engineering has emerged as a promising method to address the need for sustained and robust cellular differentiation and extracellular matrix production. As a result, gene therapy has been established as a conventional approach to enhance cellular activities for skeletal tissue repair. Recent literature clearly demonstrates that genetic engineering is a principal factor in constructing effective methods for tissue engineering approaches to bone, cartilage, and connective tissue regeneration. This review highlights this literature, including advances in the development of efficacious gene carriers, novel cell sources, successful delivery strategies, and optimal target genes. The current status of the field and the challenges impeding the clinical realization of these approaches are also discussed.

Use of NASA Bioreactor in Engineering Tissue for Bone Repair

Science.gov (United States)

Duke, Pauline

1998-01-01

This study was proposed in search for a new alternative for bone replacement or repair. Because the systems commonly used in repair of bony defects form bone by going through a cartilaginous phase, implantation of a piece of cartilage could enhance the healing process by having a more advanced starting point. However, cartilage has seldom been used to replace bone due, in part, to the limitations in conventional culture systems that did not allow production of enough tissue for implants. The NASA-developed bioreactors known as STLV (Slow Turning Lateral Vessel) provide homogeneous distribution of cells, nutrients, and waste products, with less damaging turbulence and shear forces than conventional systems. Cultures under these conditions have higher growth rates, viability, and longevity, allowing larger "tissue-like" aggregates to form, thus opening the possibilities of producing enough tissue for implantation, along with the inherent advantages of in vitro manipulations. To assure large numbers of cells and to eliminate the use of timed embryos, we proposed to use an immortalized mouse limb bud cell line as the source of cells.

Teaching Radioactive Waste Management in an Undergraduate Engineering Program - 13269

Energy Technology Data Exchange (ETDEWEB)

Ikeda, Brian M. [Faculty of Energy Systems and Nuclear Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, Ontario L1H 7K4 (Canada)

2013-07-01

The University of Ontario Institute of Technology is Ontario's newest university and the only one in Canada that offers an accredited Bachelor of Nuclear Engineering (Honours) degree. The nuclear engineering program consists of 48 full-semester courses, including one on radioactive waste management. This is a design course that challenges young engineers to develop a fundamental understanding of how to manage the storage and disposal of various types and forms of radioactive waste, and to recognize the social consequences of their practices and decisions. Students are tasked with developing a major project based on an environmental assessment of a simple conceptual design for a waste disposal facility. They use collaborative learning and self-directed exploration to gain the requisite knowledge of the waste management system. The project constitutes 70% of their mark, but is broken down into several small components that include, an environmental assessment comprehensive study report, a technical review, a facility design, and a public defense of their proposal. Many aspects of the project mirror industry team project situations, including the various levels of participation. The success of the students is correlated with their engagement in the project, the highest final examination scores achieved by students with the strongest effort in the project. (authors)

Teaching Radioactive Waste Management in an Undergraduate Engineering Program - 13269

International Nuclear Information System (INIS)

Ikeda, Brian M.

2013-01-01

The University of Ontario Institute of Technology is Ontario's newest university and the only one in Canada that offers an accredited Bachelor of Nuclear Engineering (Honours) degree. The nuclear engineering program consists of 48 full-semester courses, including one on radioactive waste management. This is a design course that challenges young engineers to develop a fundamental understanding of how to manage the storage and disposal of various types and forms of radioactive waste, and to recognize the social consequences of their practices and decisions. Students are tasked with developing a major project based on an environmental assessment of a simple conceptual design for a waste disposal facility. They use collaborative learning and self-directed exploration to gain the requisite knowledge of the waste management system. The project constitutes 70% of their mark, but is broken down into several small components that include, an environmental assessment comprehensive study report, a technical review, a facility design, and a public defense of their proposal. Many aspects of the project mirror industry team project situations, including the various levels of participation. The success of the students is correlated with their engagement in the project, the highest final examination scores achieved by students with the strongest effort in the project. (authors)

Scenario logic and probabilistic management of risk in business and engineering

CERN Document Server

Solojentsev, E D

2005-01-01

In this volume the methodological aspects of the scenario logic and probabilistic (LP) non-success risk management are considered. The theoretical bases of scenario non-success risk LP-management in business and engineering are also stated. Methods and algorithms for the scenario risk LP-management in problems of classification, investment and effectiveness are described. Risk LP- models and results of numerical investigations for credit risks, risk of frauds, security portfolio risk, risk of quality, accuracy, and risk in multi-stage systems reliability are given. In addition, a rather large number of new problems of estimation, analysis and management of risk are considered. Software for risk problems based on LP-methods, LP-theory, and GIE are described too. Audience This volume is intended for experts and scientists in the area of the risk in business and engineering, in problems of classification, investment and effectiveness, and post-graduates in those subject areas.

Synthetic biology meets tissue engineering.

Science.gov (United States)

Davies, Jamie A; Cachat, Elise

2016-06-15

Classical tissue engineering is aimed mainly at producing anatomically and physiologically realistic replacements for normal human tissues. It is done either by encouraging cellular colonization of manufactured matrices or cellular recolonization of decellularized natural extracellular matrices from donor organs, or by allowing cells to self-organize into organs as they do during fetal life. For repair of normal bodies, this will be adequate but there are reasons for making unusual, non-evolved tissues (repair of unusual bodies, interface to electromechanical prostheses, incorporating living cells into life-support machines). Synthetic biology is aimed mainly at engineering cells so that they can perform custom functions: applying synthetic biological approaches to tissue engineering may be one way of engineering custom structures. In this article, we outline the 'embryological cycle' of patterning, differentiation and morphogenesis and review progress that has been made in constructing synthetic biological systems to reproduce these processes in new ways. The state-of-the-art remains a long way from making truly synthetic tissues, but there are now at least foundations for future work. © 2016 Authors; published by Portland Press Limited.

Bulk material engineering and procurement management of NPS

International Nuclear Information System (INIS)

Fu Sanhong; Fan Kai

2005-01-01

In a nuclear power project, bulk material is often not in an outstanding position, compared to equipment, yet bulk material is one of most difficult part in engineering and procurement management. If the schedule is not in good control, it will seriously hamper the progress of the whole project. The article explores bulk material engineering and procurement management of NPS, illustrated with tables and graphs. First, major difficult aspects of bulk material procurement are described. On one hand, bulk material is really bulky in kind. We must have detail information of manufacturers, manufacture duration, and take good control of bidding schedule. On the other hand, when an order is placed, we need to make clear everything in the procurement package, such as material types, delivery batches, quantity of each batch and delivery schedule, which is a tremendous work. Then, a schedule conflict is analyzed: when an order is placed, the detail type and quantity cannot be defined (since the construction design is not finished yet). To settle this conflict, the concept 'Requirement Schedule Curve' is brought forward, along with the calculation method. To get this curve, we need to make use of the technical data of the reference power station, along with the site construction schedule, to produce a site quantity requirement curve varying from time, for each type of material. Last, based on the 'Requirement Schedule Curve', we are able to build a unified database to control the engineering, procurement, manufacturing and delivery schedule, so as to procure precisely, manufacture on time, and optimize the storage. In this way, the accurate control of bulk material engineering and procurement schedule can be achieved. (authors)

Analytical concepts for health management systems of liquid rocket engines

Science.gov (United States)

Williams, Richard; Tulpule, Sharayu; Hawman, Michael

1990-01-01

Substantial improvement in health management systems performance can be realized by implementing advanced analytical methods of processing existing liquid rocket engine sensor data. In this paper, such techniques ranging from time series analysis to multisensor pattern recognition to expert systems to fault isolation models are examined and contrasted. The performance of several of these methods is evaluated using data from test firings of the Space Shuttle main engines.

DNA repair , cell repair and radiosensitivity

International Nuclear Information System (INIS)

Zhestyanikov, V.D.

1983-01-01

Data obtained in laboratory of radiation cytology and literature data testifying to a considerable role of DNA repair in cell sensitivity to radiation and chemical DNA-tropic agents have been considered. Data pointing to the probability of contribution of inducible repair of DNA into plant cells sensitivity to X-rays are obtained. Certain violations of DNA repair do not result in the increase of radiosensitivity. It is assumed that in the cases unknown mechanisms of DNA repair operate

Ageing management studies of RAPS-1

International Nuclear Information System (INIS)

Bohra, A.K.; Jain, L.K.; Joshi, K.M.

2006-01-01

Unit-l of Rajasthan Atomic Power Station (RAPS-1) is the first nuclear power plant of India with pressurized heavy water reactor. The construction of Unit-l of Rajasthan Atomic Power Station (RAPS-1) was started in the year 1966 in collaboration with Canada. The Unit-1 achieved first criticality on August 1972 and was first synchronized to Grid on November 1972. During initial operation of the Unit, several problems were faced in its various systems and these were addressed by incorporating various engineering changes and procedures. In this unit various major innovative repairs were done like end shield leak repair, OPRD leak repair. Considering the operation of various systems of Unit-1, since year 1971 it was imperative to study ageing degradation mechanisms and mitigating measures were to be taken. Although the ageing management is a continuous process the opportunity of Unit-1 shutdown for upgradations from 30-04-2002 to 08-02-2004 was utilized for inspection and assessment of health of various SSC, which otherwise could not have been done with unit in operational state. This paper contains the following in detail. (1) Ageing management programme, its objectives and scope (2) Methodology of ageing management studies - Replacement and upgradation -Additional inspection programme based on ageing management review - Statistical analysis of ageing degradation occurrence - Estimation of residual life span of cables and relays (3) Criteria for selection of components for ageing management programme (4) Findings of ageing management studies-case studies. The ageing study done for RAPS-1 indicated that appropriate ageing monitoring methods and procedures exist in the station for taking timely mitigating measures. The technological obsoleteness has been overcome by installing new components of latest technology. On overall assessment, the Unit-1 was considered fit for further service. (author)

Carbon nanotubes in neuroregeneration and repair.

Science.gov (United States)

Fabbro, Alessandra; Prato, Maurizio; Ballerini, Laura

2013-12-01

In the last decade, we have experienced an increasing interest and an improved understanding of the application of nanotechnology to the nervous system. The aim of such studies is that of developing future strategies for tissue repair to promote functional recovery after brain damage. In this framework, carbon nanotube based technologies are emerging as particularly innovative tools due to the outstanding physical properties of these nanomaterials together with their recently documented ability to interface neuronal circuits, synapses and membranes. This review will discuss the state of the art in carbon nanotube technology applied to the development of devices able to drive nerve tissue repair; we will highlight the most exciting findings addressing the impact of carbon nanotubes in nerve tissue engineering, focusing in particular on neuronal differentiation, growth and network reconstruction. © 2013.

Optimal control for integrated emission management in diesel engines

NARCIS (Netherlands)

Donkers, M.C.F.; van Schijndel, J.; Heemels, W.P.M.H.; Willems, F.

2017-01-01

Integrated Emission Management (IEM) is a supervisory control strategy that minimises operational costs (consisting of fuel and AdBlue) for diesel engines with an aftertreatment system, while satisfying emission constraints imposed by legislation. In most work on IEM, a suboptimal heuristic

Optimal control for integrated emission management in diesel engines

NARCIS (Netherlands)

Donkers, M.C.F.; Schijndel, J. van; Heemels, W.P.M.H.; Willems, F.P.T.

2016-01-01

Integrated Emission Management (IEM) is a supervisory control strategy that minimises operational costs (consisting of fuel and AdBlue) for diesel engines with an aftertreatment system, while satisfying emission constraints imposed by legislation. In most work on IEM, a suboptimal heuristic

Dynamic programming for Integrated Emission Management in diesel engines

NARCIS (Netherlands)

Schijndel, J. van; Donkers, M.C.F.; Willems, F.P.T.; Heemels, W.P.M.H.

2014-01-01

Integrated Emission Management (IEM) is a supervisory control strategy that aims at minimizing the operational costs of diesel engines with an aftertreatment system, while satisfying emission constraints imposed by legislation. In previous work on IEM, a suboptimal real-time implementable solution

Laboratory and On-Site Tests for Rapid Runway Repair

Directory of Open Access Journals (Sweden)

Federico Leonelli

2017-11-01

Full Text Available The attention to rapid pavement repair has grown fast in recent decades: this topic is strategic for the airport management process for civil purposes and peacekeeping missions. This work presents the results of laboratory and on-site tests for rapid runway repair, in order to analyse and compare technical and mechanical performances of 12 different materials currently used in airport. The study focuses on site repairs, a technique adopted most frequently than repairs with modular elements. After describing mechanical and physical properties of the examined materials (2 bituminous emulsions, 5 cement mortars, 4 cold bituminous mixtures and 1 expanding resin, the study presents the results of carried out mechanical tests. The results demonstrate that the best performing material is a one-component fast setting and hardening cement mortar with graded aggregates. This material allows the runway reopening 6 h after the work. A cold bituminous mixture (bicomponent premixed cold asphalt with water as catalyst and the ordinary cement concrete allow the reopening to traffic after 18 h, but both ensure a lower service life (1000 coverages than the cement mortar (10,000 coverages. The obtained results include important information both laboratory level and field, and they could be used by airport management bodies and road agencies when scheduling and evaluating pavement repairs.

Role of DNA repair in repair of cytogenetic damages. Slowly repaired DNA injuries involved in cytogenetic damages repair

International Nuclear Information System (INIS)

Zaichkina, S.I.; Rozanova, O.M.; Aptikaev, G.F.; Ganassi, E.Eh.

1989-01-01

Caffeine was used to study the kinetics of cytogenetic damages repair in Chinese hamster fibroblasts. Its half-time (90 min) was shown to correlate with that of repair of slowly repaired DNA damages. The caffeine-induced increase in the number of irreparable DNA damages, attributed to inhibition of double-strand break repair, is in a quantitative correlation with the effect of the cytogenetic damage modification

Engineering and management experience at Texas A&M Transportation Institute

Science.gov (United States)

Chowdhury, Arif Tahjibul

This manuscript presents the author's engineering and management experience during his internship in the Materials and Pavements (M&P) Division at the Texas A&M Transportation Institute (TTI), and is a record of study for the Doctor of Engineering at Texas A&M University. Through this internship, he met his established internship objectives of gaining technical knowledge as well as knowledge and skills in project management, organizational communication, and quality management of pavement condition data, and of attaining professional development. In meeting these objectives, the author describes the history, mission, and organizational structure of his workplace. He also presents his experience of developing and delivering a two-week training course on pavement design and construction in Kosovo. Participating in a number of professional development training courses and other activities prepared him for working as an engineering manager. These activities include Delta-T leadership training, an instructor development course, a time management and organizational skills course, and the M&P Division lecture series. Leadership and skills learned through the Delta-T program were beneficial for the employee as well as the employer. For the class project, the author and his teammates performed a study dealing with improving TTI's deliverables. The Delta-T team composed a report summarizing their efforts of examining the current state of TTI's project deliverables, the deliverables' shortcomings, and potential enhancements to expand the deliverables' appeal to additional types of potential users outside the traditional research community. The team also developed a prototype web-based model of deliverables and presented some implementation recommendations. Participating in the Texas Department of Transportation's (TxDOT's) pavement surface distress data collection program enabled the author to become familiar with pavement distress data quality management and thus attain the

Emerging Biofabrication Strategies for Engineering Complex Tissue Constructs

DEFF Research Database (Denmark)

Pedde, R. Daniel; Mirani, Bahram; Navaei, Ali

2017-01-01

, outlines the use of common biomaterials and advanced hybrid scaffolds, and describes several design considerations including the structural, physical, biological, and economical parameters that are crucial for the fabrication of functional, complex, engineered tissues. Finally, the applications...... of these biofabrication strategies in neural, skin, connective, and muscle tissue engineering are explored.......The demand for organ transplantation and repair, coupled with a shortage of available donors, poses an urgent clinical need for the development of innovative treatment strategies for long-term repair and regeneration of injured or diseased tissues and organs. Bioengineering organs, by growing...

Inventory management of repairable service parts for personal computers : A case study

NARCIS (Netherlands)

Ashayeri, J.; Heuts, R.M.J.; Jansen, A.; Szczerba, B.

1994-01-01

Recent years have seen an increase of interest in the field of service parts inventory - particularly in computer industry. The computer industry is a highly competitive industry; products have to be repaired as quickly as possible, since slow repair can lead to loss of future business to

Magnox Electric Littlebrook reactor inspection and repair rehearsal facility

International Nuclear Information System (INIS)

Barnes, S.A.; Clayton, R.; Gaydon, B.G.; Ramsey, B.H.

1996-01-01

Magnox reactors, although designed to be maintenance free during their operational life, have nevertheless highlighted the need for test rig facilities to train operators in the methods and techniques of reactor inspection and repair. The history of the facility for reactor engineering development (FRED) is described and its present role as a repair rehearsal facility noted. Advances in computer graphics may, in future, mean that such operator training will be virtual reality rather than analog reality based; however the need for such rigs to commission techniques and equipment and to establish performance and reliability is likely to continue. (UK)

Development of combustion management concept for natural-aspirated small diesel engine; Shizen kyuki kogata diesel engine no nensho seigyo concept no kaihatsu

Energy Technology Data Exchange (ETDEWEB)

Wada, T; Kawano, T; Shoji, M; Kuniyosh, M; Yamashita, O; Nagao, A [Mazda Motor Corp., Tokyo (Japan); Yoshikawa, S [Zexel Corp., Tokyo (Japan)

1997-10-01

We have developed a combustion management concept for natural-aspirated small IDI diesel engines and achieved higher power, lower exhaust emissions and more comfort. The concept is related to improvements of intake volumetric efficiency, EGR effect, mixture formation caused by combustion chamber and spray characteristics, engine management system and after treatment device. This paper describes the concept and experimental results. 3 refs., 14 figs., 1 tab.

Cell-Based Strategies for Meniscus Tissue Engineering

Science.gov (United States)

Niu, Wei; Guo, Weimin; Han, Shufeng; Zhu, Yun; Liu, Shuyun; Guo, Quanyi

2016-01-01

Meniscus injuries remain a significant challenge due to the poor healing potential of the inner avascular zone. Following a series of studies and clinical trials, tissue engineering is considered a promising prospect for meniscus repair and regeneration. As one of the key factors in tissue engineering, cells are believed to be highly beneficial in generating bionic meniscus structures to replace injured ones in patients. Therefore, cell-based strategies for meniscus tissue engineering play a fundamental role in meniscal regeneration. According to current studies, the main cell-based strategies for meniscus tissue engineering are single cell type strategies; cell coculture strategies also were applied to meniscus tissue engineering. Likewise, on the one side, the zonal recapitulation strategies based on mimicking meniscal differing cells and internal architectures have received wide attentions. On the other side, cell self-assembling strategies without any scaffolds may be a better way to build a bionic meniscus. In this review, we primarily discuss cell seeds for meniscus tissue engineering and their application strategies. We also discuss recent advances and achievements in meniscus repair experiments that further improve our understanding of meniscus tissue engineering. PMID:27274735

Cylinder pressure sensing and model-based control in engine management systems

Energy Technology Data Exchange (ETDEWEB)

Truscott, A.; Noble, A.; Akoachere, A.; Beaumont, A. [Ricardo Consulting Engineers Ltd., Bridge Works (United Kingdom); Mueller, R.; Hart, M. [FT2/EA, HPC T721, DaimlerChrysler AG, Stuttgart (Germany); Kroetz, G. [FT2/M, DaimlerChrysler AG, Muenchen (Germany); Cavalloni, C.; Gnielka, M. [Kistler Instrumente AG, Winterthur (Switzerland)

2000-07-01

Global demands on fuel economy and lower emissions from automotive vehicles have had a large impact on the development of engine management systems (EMS) in recent years. However, despite the advances in system hardware, the software programmed into these systems has yet to utilise the full potential of modern control methodologies. Model based control and diagnostics is the next step forward in the development of EMS software with the potential of providing improvements in cost, efficiency, emissions and comfort. However, the full utilisation of such techniques requires very close monitoring of engine conditions. This is made possible with the advent of new inexpensive sensor technology that can withstand the harsh environment of the combustion chamber. To exploit the above advances, the AENEAS collaborative project is being carried out by Ricardo, DaimlerChrysler and Kistler, with financial support from the European Commission and Swiss government, and has the objective of realising the benefits of cylinder pressure based engine management system (CPEMS) technology. This paper describes the application of CPEMS technology to a spark ignition (SI) engine. It describes how the combination of model based algorithms, incorporating physical principles, and cylinder pressure sensing can provide an effective means of engine control and diagnostics. (orig.)

UNDERSTANDING THAI CULTURE AND ITS IMPACT ON REQUIREMENTS ENGINEERING PROCESS MANAGEMENT DURING INFORMATION SYSTEMS DEVELOPMENT

Directory of Open Access Journals (Sweden)

Theerasak Thanasankit

2002-01-01

Full Text Available This paper explores the impact of Thai culture on managing the decision making process in requirements engineering and contribution a better understand of its influence on the management of requirements engineering process. The paper illustrates the interaction of technology and culture and shows that rather than technology changing culture, culture can change the way technology is used. Thai culture is naturally inherent in Thai daily life and Thais bring that into their work practices. The concepts of power and uncertainty in Thai culture contribute toward hierarchical forms of communication and decision making process in Thailand, especially during requirements engineering, where information systems requirements need to be established for further development. The research shows that the decision making process in Thailand tends to take a much longer time, as every stage during requirements engineering needs to be reported to management for final decisions. The tall structure of Thai organisations also contributes to a bureaucratic, elongated decision-making process during information systems development. Understanding the influence of Thai culture on requirements engineering and information systems development will assist multinational information systems consulting organisations to select, adapt, better manage, or change requirements engineering process and information systems developments methodologies to work best with Thai organisations.

Prediction of Combine Economic Life Based on Repair and Maintenance Costs Model

Directory of Open Access Journals (Sweden)

A Rohani

2014-09-01

Full Text Available Farm machinery managers often need to make complex economic decisions on machinery replacement. Repair and maintenance costs can have significant impacts on this economic decision. The farm manager must be able to predict farm machinery repair and maintenance costs. This study aimed to identify a regression model that can adequately represent the repair and maintenance costs in terms of machine age in cumulative hours of use. The regression model has the ability to predict the repair and maintenance costs for longer time periods. Therefore, it can be used for the estimation of the economic life. The study was conducted using field data collected from 11 John-Deer 955 combine harvesters used in several western provinces of Iran. It was found that power model has a better performance for the prediction of combine repair and maintenance costs. The results showed that the optimum replacement age of John-Deer 955 combine was 54300 cumulative hours.

Tissue Engineering of the Urethra: A Systematic Review and Meta-analysis of Preclinical and Clinical Studies

NARCIS (Netherlands)

Versteegden, L.R.; Jonge, P. de; Hout, J. in't; Kuppevelt, T.H. van; Oosterwijk, E.; Feitz, W.F.J.; Vries, R.B.M. de; Daamen, W.F.

2017-01-01

CONTEXT: Urethra repair by tissue engineering has been extensively studied in laboratory animals and patients, but is not routinely used in clinical practice. OBJECTIVE: To systematically investigate preclinical and clinical evidence of the efficacy of tissue engineering for urethra repair in order

Silk fibroin-chondroitin sulfate scaffold with immuno-inhibition property for articular cartilage repair.

Science.gov (United States)

Zhou, Feifei; Zhang, Xianzhu; Cai, Dandan; Li, Jun; Mu, Qin; Zhang, Wei; Zhu, Shouan; Jiang, Yangzi; Shen, Weiliang; Zhang, Shufang; Ouyang, Hong Wei

2017-11-01

The demand of favorable scaffolds has increased for the emerging cartilage tissue engineering. Chondroitin sulfate (CS) and silk fibroin have been investigated and reported with safety and excellent biocompatibility as tissue engineering scaffolds. However, the rapid degradation rate of pure CS scaffolds presents a challenge to effectively recreate neo-tissue similar to natural articular cartilage. Meanwhile the silk fibroin is well used as a structural constituent material because its remarkable mechanical properties, long-lasting in vivo stability and hypoimmunity. The application of composite silk fibroin and CS scaffolds for joint cartilage repair has not been well studied. Here we report that the combination of silk fibroin and CS could synergistically promote articular cartilage defect repair. The silk fibroin (silk) and silk fibroin/CS (silk-CS) scaffolds were fabricated with salt-leaching, freeze-drying and crosslinking methodologies. The biocompatibility of the scaffolds was investigated in vitro by cell adhesion, proliferation and migration with human articular chondrocytes. We found that silk-CS scaffold maintained better chondrocyte phenotype than silk scaffold; moreover, the silk-CS scaffolds reduced chondrocyte inflammatory response that was induced by interleukin (IL)-1β, which is in consistent with the well-documented anti-inflammatory activities of CS. The in vivo cartilage repair was evaluated with a rabbit osteochondral defect model. Silk-CS scaffold induced more neo-tissue formation and better structural restoration than silk scaffold after 6 and 12weeks of implantation in ICRS histological evaluations. In conclusion, we have developed a silk fibroin/ chondroitin sulfate scaffold for cartilage tissue engineering that exhibits immuno-inhibition property and can improve the self-repair capacity of cartilage. Severe cartilage defect such as osteoarthritis (OA) is difficult to self-repair because of its avascular, aneural and alymphatic nature

Tissue-Derived Extracellular Matrix Bioscaffolds: Emerging Applications in Cartilage and Meniscus Repair.

Science.gov (United States)

Monibi, Farrah A; Cook, James L

2017-08-01

Musculoskeletal injuries are a common problem in orthopedic practice. Given the long-term consequences of unaddressed cartilage and meniscal pathology, a number of treatments have been attempted to stimulate repair or to replace the injured tissue. Despite advances in orthopedic surgery, effective treatments for cartilage and meniscus injuries remain a significant clinical challenge. Tissue engineering is a developing field that aims to regenerate injured tissues with a combination of cells, scaffolds, and signals. Many natural and synthetic scaffold materials have been developed and tested for the repair and restoration of a number of musculoskeletal tissues. Among these, biological scaffolds derived from cell and tissue-derived extracellular matrix (ECM) have shown great promise in tissue engineering given the critical role of the ECM for maintaining the biological and biomechanical properties, structure, and function of native tissues. This review article presents emerging applications for tissue-derived ECM scaffolds in cartilage and meniscus repair. We examine normal ECM composition and the current and future methods for potential treatment of articular cartilage and meniscal defects with decellularized scaffolds.

Compatibility of repair concretes in the aggressive environment of the South of Iran

International Nuclear Information System (INIS)

Parhizkar, T.; Ramezaniapour, A.A.; Hillemeier, B.; Ghasemi, A.M.R.; Mozafari, N.

2006-01-01

Deterioration of reinforced concrete structures, namely due to corrosion of reinforcement, in the south of Iran, on the coasts of the Gulf region has become a major problem in recent years. The high cost involved in repairing and strengthening of deteriorated concrete structures in this region makes it essential that the repair materials used are compatible enough to match the residual service life of the structure. This paper presents the engineering and compatibility-related properties of two repair concretes containing silica fume and styrene butadiene rubber latex (SBR) under simulated hot and humid conditions similar to the aggressive environment of the south of Iran. A normal cement-based repair concrete was used as control. Mechanical properties were assessed and the dimension stability of the repair concrete was also evaluated. The results of this investigation show that the concrete containing silica fume and the polymer-modified concrete are appropriate materials for repair in the severe environmental conditions of the Gulf region. (author)

Energy Management of a Hybrid-Power Gas Engine-Driven Heat Pump

Directory of Open Access Journals (Sweden)

Qingkun Meng

2015-10-01

Full Text Available The hybrid-power gas engine-driven heat pump (HPGHP combines hybrid power technology with a gas engine heat pump. The engine in the power system is capable of operating constantly with high thermal efficiency and low emissions during different operating modes. In this paper, the mathematical models of various components is established, including the engine thermal efficiency map and the motor efficiency map. The comprehensive charging/discharging efficiency model and energy management optimization strategy model which is proposed to maximize the efficiency of instantaneous HPGHP system are established. Then, different charging/discharging torque limits are obtained. Finally, a novel gas engine economical zone control strategy which combined with the SOC of battery in real time is put forward. The main operating parameters of HPGHP system under energy management are simulated by Matlab/Simulink and validated by experimental data, such as engine and motor operating torque, fuel consumption rate and comprehensive efficiency, etc. The results show that during 3600 s’ run-time, the SOC value of battery packs varies between 0.58 and 0.705, the fuel consumption rate reaches minimum values of approximately 291.3 g/(kW h when the compressor speed is nearly 1550 rpm in mode D, the engine thermal efficiency and comprehensive efficiency reach maximum values of approximately 0.2727 and 0.2648 when the compressor speed is 1575 rpm and 1475 rpm, respectively, in mode D. In general, the motor efficiency can be maintained above 0.85 in either mode.

STUDY OF VARIOUS MODALITIES IN MANAGEMENT OF INCISION HERNIA REPAIR

Directory of Open Access Journals (Sweden)

Raghu Rachha

2018-03-01

Full Text Available BACKGROUND Incisional hernias are a major problem following abdominal surgery and their repairs are among the common surgeries done by a general surgeon.1 Besides the preoperative factors such as anaemia, BMI over 25 kg/m2 and smoking which are leading causes contributing to the development of Incisional hernia, laparotomy performed through the abdominal incision doubles the risk of IH.2 In addition, wound infection, increases the risk of IH formation by 1.9 times.3 If left unattended they may attain large size therefore cause discomfort and lead to the complications like Obstruction, Strangulation, Incarceration increasing the risk of morbidity and mortality.4 Treatment of IH involves further major surgery and the results may be poor, with the recurrence rates of up to 49% reported.5 A wide spectrum of surgical techniques have been developed and recommended ranging from sutured techniques to the various types of prosthetic mesh. MATERIALS AND METHODS 30 patients were studied who presented to emergency department with incisional hernias during August 2014 – September 2016 at Gandhi Medical College and Hospital. All patients underwent definitive treatment. RESULTS From our study it is observed that 1. The maximum cases of incisional hernias presenting to the emergency surgical department were found to be in 51-60 years age group. 2. There was female preponderance. 3. Obstruction is the most common presenting symptom found in 60% of cases followed by irreducibility (33.3% and strangulation (6.67%. 4. The onset of incisional hernias is more after 10 years following previous surgery. 5. Among 30 patients, bowel was viable in 18 patients (60% and mesh repair was done in 13 patients. Bowel was gangrenous in 12 patients (40% and anatomical repair was done in 17 patients. 6. Out of 30, women got infected in 11 patients (36.67% wound dehiscence noted in 5 patients (16.67%. 7. The recurrence rate was 6.67% with 6 months follow up. CONCLUSION 1. The mean

ORGANIZATION OF FUTURE ENGINEERS' PROJECT-BASED LEARNING WHEN STUDYING THE PROJECT MANAGEMENT METHODOLOGY

Directory of Open Access Journals (Sweden)

Halyna V. Lutsenko

2015-02-01

Full Text Available The peculiarities of modern world experience of implementation of project-based learning in engineering education have been considered. The potential role and place of projects in learning activity have been analyzed. The methodology of organization of project-based activity of engineering students when studying the project management methodology and computer systems of project management has been proposed. The requirements to documentation and actual results of students' projects have been described in detail. The requirements to computer-aided systems of project management developed by using Microsoft Project in the scope of diary scheduling and resources planning have been formulated.

Biomaterial applications in neural therapy and repair

Institute of Scientific and Technical Information of China (English)

Harmanvir Ghuman; Michel Modo

2017-01-01

The use of biomaterials,such as hydrogels,as a scaffold to deliver cells and drugs is becoming increasingly common to treat neurological conditions,including stroke.With a limited intrinsic ability to regenerate after injury,innovative tissue engineering strategies have shown the potential of biomaterials in facilitating neural tissue regeneration and functional recovery.Using biomaterials can not only promote the survival and integration of transplanted cells in the existing circuitry,but also support controlled site specific delivery of therapeutic drugs.This review aims to provide the reader an understanding of the brain tissue microenvironment after injury,biomaterial criteria that support tissue repair,commonly used natural and synthetic biomaterials,benefits of incorporating cells and neurotrophic factors,as well as the potential of endogenous neurogenesis in repairing the injured brain.

Lineage plasticity and cell biology of fibrocartilage and hyaline cartilage: Its significance in cartilage repair and replacement

International Nuclear Information System (INIS)

Freemont, Anthony J.; Hoyland, Judith

2006-01-01

Cartilage repair is a major goal of modern tissue engineering. To produce novel engineered implants requires a knowledge of the basic biology of the tissues that are to be replaced or reproduced. Hyaline articular cartilage and meniscal fibrocartilage are two tissues that have excited attention because of the frequency with which they are damaged. A basic strategy is to re-engineer these tissues ex vivo by stimulating stem cells to differentiate into the cells of the mature tissue capable of producing an intact functional matrix. In this brief review, the sources of cells for tissue engineering cartilage and the culture conditions that have promoted differentiation are discussed within the context of natural cartilage repair. In particular, the role of cell density, cytokines, load, matrices and oxygen tension are discussed

Lineage plasticity and cell biology of fibrocartilage and hyaline cartilage: Its significance in cartilage repair and replacement

Energy Technology Data Exchange (ETDEWEB)

Freemont, Anthony J. [Regenerative Medicine Research Group, University of Manchester, England (United Kingdom)]. E-mail: Tony.freemont@man.ac.uk; Hoyland, Judith [Regenerative Medicine Research Group, University of Manchester, England (United Kingdom)

2006-01-15

Cartilage repair is a major goal of modern tissue engineering. To produce novel engineered implants requires a knowledge of the basic biology of the tissues that are to be replaced or reproduced. Hyaline articular cartilage and meniscal fibrocartilage are two tissues that have excited attention because of the frequency with which they are damaged. A basic strategy is to re-engineer these tissues ex vivo by stimulating stem cells to differentiate into the cells of the mature tissue capable of producing an intact functional matrix. In this brief review, the sources of cells for tissue engineering cartilage and the culture conditions that have promoted differentiation are discussed within the context of natural cartilage repair. In particular, the role of cell density, cytokines, load, matrices and oxygen tension are discussed.

Initial experience of laparoscopic incisional hernia repair.

Science.gov (United States)

Razman, J; Shaharin, S; Lukman, M R; Sukumar, N; Jasmi, A Y

2006-06-01

Laparoscopic repair of ventral and incisional hernia has become increasingly popular as compared to open repair. The procedure has the advantages of minimal access surgery, reduction of post operative pain and the recurrence rate. A prospective study of laparoscopic incisional hernia repair was performed in our center from August 2002 to April 2004. Eighteen cases (n: 18) were performed during the study period. Fifteen cases (n: 15) had open hernia repair previously. Sixteen patients (n: 16) had successful repair of the hernia with the laparoscopic approach and two cases were converted to open repair. The mean hernia defect size was 156cm2. There was no intraoperative or immediate postoperative complication. The mean operating time was 100 +/- 34 minutes (75 - 180 minutes). The postoperative pain was graded as mild to moderate according to visual analogue score. The mean day of discharge after surgery was two days (1 - 3 days). During follow up, three patients (16.7%) developed seroma at the hernia sac which was resolved with conservative management after three weeks. One (5.6%) patient developed recurrence six months after surgery. In conclusion, laparoscopic repair of incisional hernia particularly recurrent hernia has been shown to be safe and effective in our centre. However, careful patient selection and acquiring the necessary advanced laparoscopic surgical skills coupled with the proper use of equipment are mandatory before embarking on this procedure.

The international emergency management and engineering conference 1995: Proceedings. Globalization of emergency management and engineering: National and international issues concerning research and applications

Energy Technology Data Exchange (ETDEWEB)

Sullivan, J.D. [ed.] [Optimal Systems, Inc., Dallas, TX (United States); Wybo, J.L. [ed.] [Ecole des Mines de Paris (France); Buisson, L. [ed.] [CEMAGREF, Saint-Martin d`Heres (France). Div. Nivologie

1995-12-31

This conference was held May 9--12, 1995 in Nice, France. The purpose of this conference was to provide a forum for exchange of state-of-the-art information to cope more effectively with emergencies. Attention is focused on advance technology from both a managerial and a scientific viewpoint. Interests include computers and communication systems as well as the social science and management aspects involved in emergency management and engineering. The major sections are: Management and Social Sciences; Training; Natural Disasters; Nuclear Hazards; Chemical Hazards; Research; and Applications. Individual papers have been processed separately for inclusion in the appropriate data bases.

Physical Limitations to Tissue Engineering of Intervertabral Disc Cells

OpenAIRE

Kobayashi, Shigeru; Baba, Hisatoshi; Takeno, Kenichi; Miyazaki, Tsuyoshi; Meir, Adam; Urban, Jill

2010-01-01

There is increasing interest in the using biological methods to repair degenerate discs. Biological repair depends on the disc maintaining a population of viable and active cells. Adequate nutrition of the disc influences the outcome of such therapies and, hence, must be considered to be a crucial parameter. Therefore, it is very important to maintain an appropriate physicochemical environment to achieve successful disc repair by biological methods and tissue engineering procedures.

Anesthetic management for combined mitral valve replacement and aortic valve repair in a patient with osteogenesis imperfecta

Directory of Open Access Journals (Sweden)

Huang Jiapeng

2011-01-01

Full Text Available Osteogenesis imperfecta is a rare disorder of connective tissues and presents multiple challenges, including difficult airway, hyperthermia, coagulopathy and respiratory dysfunction, for anesthesiologists, especially during cardiac surgery. We present anesthetic management of a patient with osteogenesis impertecta during double valve surgery. Dexmedetomidine infusion minimized the risks of malignant hyperthermia. Glidescope and in-line stabilization facilitated endotracheal intubation and protected his oral structures and cervical spine. Transesophageal echocardiography (TEE diagnosed a flail A3 segment and redundant left coronary cusp causing mitral and aortic regurgitation. The mitral valve was replaced and the aortic valve repaired. Coagulopathy was corrected according to comprehensive coagulation analysis. Glidescope, dexmedetomidine, coagulation analysis and TEE could facilitate anesthetic management in these patients.

* Comparison of Autologous, Allogeneic, and Cell-Free Scaffold Approaches for Engineered Tendon Repair in a Rabbit Model-A Pilot Study.

Science.gov (United States)

Wang, Wenbo; Deng, Dan; Wang, Bin; Zhou, Guangdong; Zhang, WenJie; Cao, Yilin; Zhang, Peihua; Liu, Wei

2017-08-01

Tendons are subjected to high strength dynamic mechanical forces in vivo. Mechanical strength is an essential requirement for tendon scaffold materials. A composite scaffold was used in this study to provide mechanical strength, which was composed of an inter part of nonwoven polyglycolic acid (PGA) fibers and an outer part of the net knitted with PGA and polylactic acid (PLA) fibers in a ratio of 4:2. This study compared three different approaches for in vivo tendon engineering, that is, cell-free scaffold and allogeneic and autologous cell seeded scaffolds, using a rabbit Achilles tendon repair model. Dermal fibroblasts were, respectively, isolated from the dermis of regular rabbits or green fluorescence protein transgenic rabbits as the autologous and the allogeneic cell sources, respectively. The cell scaffolds and cell-free scaffolds were implanted to bridge a partial segmental defect of rabbit Achilles tendon. The engineered tendons were harvested at 7 and 13 months postsurgery for various examinations. The results showed that all three groups could achieve in vivo tendon regeneration similarly with slightly better tissue formation in autologous group than in other two groups, including better scaffold degradation and relatively thicker collagen fibrils. There were no statistically significant differences in mechanical parameters among three groups. This work demonstrated that allogeneic fibroblasts and scaffold alone are likely to be used for tendon tissue engineering.

Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression.

Science.gov (United States)

Karlsson, Asa; Deb-Basu, Debabrita; Cherry, Athena; Turner, Stephanie; Ford, James; Felsher, Dean W

2003-08-19

DNA repair mechanisms are essential for the maintenance of genomic integrity. Disruption of gene products responsible for DNA repair can result in chromosomal damage. Improperly repaired chromosomal damage can result in the loss of chromosomes or the generation of chromosomal deletions or translocations, which can lead to tumorigenesis. The MYC protooncogene is a transcription factor whose overexpression is frequently associated with human neoplasia. MYC has not been previously implicated in a role in DNA repair. Here we report that the overexpression of MYC disrupts the repair of double-strand DNA breaks, resulting in a several-magnitude increase in chromosomal breaks and translocations. We found that MYC inhibited the repair of gamma irradiation DNA breaks in normal human cells and blocked the repair of a single double-strand break engineered to occur in an immortal cell line. By spectral karyotypic analysis, we found that MYC even within one cell division cycle resulted in a several-magnitude increase in the frequency of chromosomal breaks and translocations in normal human cells. Hence, MYC overexpression may be a previously undescribed example of a dominant mutator that may fuel tumorigenesis by inducing chromosomal damage.

Increasing Awareness of Sustainable Water Management for Future Civil Engineers

Science.gov (United States)

Ilic, Suzana; Karleusa, Barbara; Deluka-Tibljas, Aleksandra

2010-05-01

There are more than 1.2 billion people around the world that do not have access to drinking water. While there are plans under the United Nations Millennium Development Goals to halve this number by 2015, there are a number of regions that will be exposed to water scarcity in the coming future. Providing sufficient water for future development is a great challenge for planners and designers of water supply systems. In order to design sustainable water supplies for the future, it is important to learn how people consume water and how water consumption can be reduced. The education of future civil engineers should take into account not only technical aspects of the water supply but also the accompanying social and economical issues, and appreciated the strengths and weaknesses of traditional solutions. The Faculty of Civil Engineering, at the University of Rijeka, has begun incorporating a series of activities that engage undergraduate students and the local community to develop a mutual understanding of the future needs for sustainable management. We present one of the activities, collaboration with the Lancaster Environment Centre at Lancaster University in the UK through the field course Water and environmental management in Mediterranean context. The course, which is designed for the Lancaster University geography students, features a combination of field trips and visits to provide an understanding of the socio-economic and environmental context of water management in two counties (Istra and Primorsko-Goranska). Students from Lancaster visit the Croatian water authority and a regional water company, where they learn about current management practices and problems in managing water supplies and demand through the year. They make their own observations of current management practices in the field and learn about water consumption from the end users. One day field visit to a village in the area that is still not connected to the main water supply system is

Human adipose-derived stem cells: definition, isolation, tissue-engineering applications.

Science.gov (United States)

Nae, S; Bordeianu, I; Stăncioiu, A T; Antohi, N

2013-01-01

Recent researches have demonstrated that the most effective repair system of the body is represented by stem cells - unspecialized cells, capable of self-renewal through successive mitoses, which have also the ability to transform into different cell types through differentiation. The discovery of adult stem cells represented an important step in regenerative medicine because they no longer raises ethical or legal issues and are more accessible. Only in 2002, stem cells isolated from adipose tissue were described as multipotent stem cells. Adipose tissue stem cells benefits in tissue engineering and regenerative medicine are numerous. Development of adipose tissue engineering techniques offers a great potential in surpassing the existing limits faced by the classical approaches used in plastic and reconstructive surgery. Adipose tissue engineering clinical applications are wide and varied, including reconstructive, corrective and cosmetic procedures. Nowadays, adipose tissue engineering is a fast developing field, both in terms of fundamental researches and medical applications, addressing issues related to current clinical pathology or trauma management of soft tissue injuries in different body locations.

Some important advances in DNA repair study on the mammalian cells

International Nuclear Information System (INIS)

Xia Shouxuan.

1991-01-01

In the recent years the study of DNA damage and repair in the mammalian cells has gone deeply at gene level and got the following advances: (1) For a long time DNA has been considered to be an uniform unit in case of damage and repair. Now this concept should be replaced by the non-random distribution of damage and heterogenous repair in the genome. These would allow us to study cellular mutagenesis, carcinogenesis, aging and dying processes in great detail, and would be beneficial to the elucidation of mechanisms of radiation sickness and chemical toxicology. (2) The advent of new techniques in molecular biology has made it possible to isolate and clone the human DNA repair genes. Up to now more than ten human DNA repair genes have been cloned and these works would have an important impact on the theoretical and practical study in this field. Because DNA repair system is very complicate, voluminous work should be done in the future. (3) The technique of gene transfer has been efficiently used in the study of DNA repair in mammalian cells and has made great contribution in the cellular engineering. It could modify the genetic behavior of the gene-accepting cells, and enhance the DNA repair ability to physical and chemical damages. Human gene therapy for DNA deficient diseases is now on the day

Advanced thermal management of diesel engines; Neues Thermomanagement beim Dieselmotor

Energy Technology Data Exchange (ETDEWEB)

Wenzel, Wolfgang; Becker, Michael [BorgWarner, Ludwigsburg (Germany). Konzernvorentwicklung fuer Pkw-Antriebssysteme; Shutty, John [BorgWarner, Auburn Hills (United States). Regelung und Simulation in der Konzernvorentwicklung

2013-05-01

The potential of thermal management with respect to CO{sub 2} reduction is given by faster warm-up of engine and drivetrain, reduced losses from water pump and fan and finally the operation of the engine in an optimal temperature range. In a new approach, BorgWarner applies a variable coolant pump and a controlled coolant valve to a conventional cooling system. Both components, as well as the viscous fan clutch, are controlled by a newly developed controls approach.

Management of engineering design information

International Nuclear Information System (INIS)

Gray, J.A.

1991-01-01

Westinghouse Idaho Nuclear Company, Inc. (WINCO) purchased a Design Management software package called SHERPA for use on the $1 billion Special Isotope Separation Project Sherpa is a customizable software shell that provides for the administrative management of the design function including production, approval, distribution and configuration control of project information. This project information can be either electronic or the traditional paper hardcopy. The use of this computerized system resulted in enhanced productivity and quality performance for the management, engineering, and administrative personnel on the project. The software currently runs on an HP9000 model 835 using the HP-UX operating system. The software had been completely customized to meet specific project needs. Existing databases were converted or left in tact to be accessed through the Sherpa software. Access to the system is available through IBM PCs. Dec terminals, Sun work stations, HP terminals, and X-windows terminals, in short most existing WINCO workstations. The software and hardware were delivered in February of 1990, and the system was on-line with all necessary data converted by the end of ApriL Through the use of the electronic approval function and the highly sophisticated query capabilities of the software, a cost savings of over 1500 personnel hours were realized during the closeout of the Project. The software has since been modified for use in the management of WINCO Environmental Compliance Information including Permits, NEPA, and RECRA documentation and records. Use of this software and hardware has resulted in an increase in quality and a large cost savings to WINCO

Athletic Population with Spondylolysis: Review of Outcomes following Surgical Repair or Conservative Management

Science.gov (United States)

Panteliadis, Pavlos; Nagra, Navraj S.; Edwards, Kimberley L.; Behrbalk, Eyal; Boszczyk, Bronek

2016-01-01

Study Design  Narrative review. Objective  The study aims to critically review the outcomes associated with the surgical repair or conservative management of spondylolysis in athletes. Methods  The English literature listed in MEDLINE/PubMed was reviewed to identify related articles using the term “spondylolysis AND athlete.” The criteria for studies to be included were management of spondylolysis in athletes, English text, and no year, follow-up, or study design restrictions. The references of the retrieved articles were also evaluated. The primary outcome was time to return to sport. This search yielded 180 citations, and 25 publications were included in the review. Results  Treatment methods were dichotomized as operative and nonoperative. In the nonoperative group, 390 athletes were included. A combination of bracing with physical therapy and restriction of activities was used. Conservative measures allowed athletes to return to sport in 3.7 months (weighted mean). One hundred seventy-four patients were treated surgically. The most common technique was Buck's, using a compression screw (91/174). All authors reported satisfactory outcomes. Time to return to play was 7.9 months (weighted mean). There were insufficient studies with suitably homogenous subgroups to conduct a meta-analysis. Conclusion  There is no gold standard approach for the management of spondylolysis in the athletic population. The existing literature suggests initial therapy should be a course of conservative management with thoracolumbosacral orthosis brace, physiotherapy, and activity modification. If conservative management fails, surgical intervention should be considered. Two-sided clinical studies are needed to determine an optimal pathway for the management of athletes with spondylolysis. PMID:27556003

Role of Cartilage Forming Cells in Regenerative Medicine for Cartilage Repair

OpenAIRE

Sun, Lin; Reagan, Michaela R.; Kaplan, David L.

2010-01-01

Lin Sun1, Michaela R Reagan2, David L Kaplan1,21Department of Chemical and Biological Engineering, 2Department of Biomedical Engineering, Tufts University, Medford, MA, USAAbstract: Currently, cartilage repair remains a major challenge for researchers and physicians due to its limited healing capacity. Cartilage regeneration requires suitable cells; these must be easily obtained and expanded, able to produce hyaline matrix with proper mechanical properties, and demonstrate sustained integrati...

After-sales service of engineering industrial assets a reference framework for warranty management

CERN Document Server

González-Prida Díaz, Vicente

2014-01-01

This book explores the practical implementation of an advanced after-sales management framework devoted to warranty management. The framework is intended for companies producing either standardized or customized products, and such a management tool will facilitate organizational improvement and support innovative decision making processes for technical assistance in after-sales services.  “After–sales Service of Engineering Industrial Assets” comprises a proposal for a warranty management framework, with an account of the different methods that can be used to improve decision making in the different stages of the after-sales service management process, and strategies for strengthening the structure and foundations of the framework. A review of the fundamental issues and current research topics in warranty management and after sales services is also provided, which is exemplified by a case study. This book is intended for postgraduates, researchers and engineers who are interested in aftersales manageme...

Relationship management in preparation for the new engineering projects

Directory of Open Access Journals (Sweden)

Magomedova Julia Yurievna

2011-07-01

Full Text Available The author reveals the constituent elements of the customer relationship and the Executive in the preparation of a new engineering projects. Relationships are built with a focus on effective risk management in the execution of the project on energy efficiency a major consumer.

ROCLA robots repaired after tough times

CERN Multimedia

Patrice Loïezi

2004-01-01

The team of five welders and five mechanics, represented by Pascal Mésenge (right) and Fabrice Multon (left), worked during two week-ends to repair the two ROCLA. At the centre, Oliver Boettcher, technical manager for the robot.

Critical needs for piston engine overhaul centre in Malaysia

Science.gov (United States)

Khairuddin, M. H.; Yahya, M. Y.; Johari, M. K.

2017-12-01

Piston engine overhaul centre (PEOC) is the branch of aviation Maintenance, Repair and Overhaul (MRO) providers, which plays a pivotal role in maintaining the fleet of business and commercial aircraft in the world. The centre typically offers three main MRO capabilities: airframe, engine and component services. Companies holding a PEOC(s) are all subjected to stringent procedures and conditions regulated and audited by the International Civil Aviation Organization. Currently, piston engine maintenance and repair for Asian countries is conducted only in Singapore. The focus of this study is to establish the needs for a PEOC in Malaysia, which will cater almost all small local aircraft companies such as transport and flying school companies.

Contemporary methods of emergency repair works on transit pipelines. Repair works on in-service pipelines

International Nuclear Information System (INIS)

Olma, T.; Winckowski, J.

2007-01-01

The paper presents modern methods and relevant technologies of pipeline failure repairs, basing on TD Williamson technique for hermetic plugging of gas pipelines without interrupting service. Rules for management of emergency situations on the Polish Section of Yamal - Europe Transit Gas Pipeline are being discussed as well. (author)

Enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation

Energy Technology Data Exchange (ETDEWEB)

Yarosh, Daniel B

2002-11-30

The goal of DNA repair enzyme therapy is the same as that for gene therapy: to rescue a defective proteome/genome by introducing a substitute protein/DNA. The danger of inadequate DNA repair is highlighted in the genetic disease xeroderma pigmentosum. These patients are hypersensitive to sunlight and develop multiple cutaneous neoplasms very early in life. The bacterial DNA repair enzyme T4 endonuclease V was shown over 25 years ago to be capable of reversing the defective repair in xeroderma pigmentosum cells. This enzyme, packaged in an engineered delivery vehicle, has been shown to traverse the stratum corneum, reach the nuclei of living cells of the skin, and enhance the repair of UV-induced cyclobutane pyrimidine dimers (CPD). In such a system, changes in DNA repair, mutagenesis, and cell signaling can be studied without manipulation of the genome.

Urinary function after Snodgrass repair of distal hypospadias: comparison with the Mathieu repair.

Science.gov (United States)

Scarpa, Maria Grazia; Castagnetti, Marco; Berrettini, Alfredo; Rigamonti, Waifro; Musi, Luciano

2010-05-01

To evaluate urinary function in patients with distal hypospadias undergoing repair by the tubularized incised-plate urethroplasty (TIP or Snodgrass), compare the results with those in patients treated by the Mathieu technique, and show the potential issues inherent to the evaluation of such results. A cross-sectional assessment was performed of uncomplicated distal hypospadias operated on during a 3-year period, already toilet trained, and able to void volitionally. Evaluation included clinical assessment urinary symptoms and urinary stream, and uroflowmetry. Out of 83 patients operated on during the study period, 10 (12%) developed complication and 32 were not toilet trained or refused to participate in the study. Median follow-up in the remaining 41 patients included in the study was 20 (3-36) months. None of these patients presented voiding symptoms or urinary stream abnormalities. Uroflowmetry was normal in 30 cases and obstructive in 11 (27%). An obstructive flow pattern was more common in patients undergoing TIP versus Mathieu repair, 8 of 19 (42%) versus 3 of 22 (14%), respectively (P = 0.07). Four TIP cases with an obstructive uroflow pattern were managed conservatively. Although both the TIP and the Mathieu repair allow good results in terms of urinary function after distal hypospadias repairs, the TIP technique seems more likely to be associated with urine flow pattern abnormalities. The actual clinical relevance of this finding remains ill defined.

Hydrogels That Allow and Facilitate Bone Repair, Remodeling, and Regeneration.

Science.gov (United States)

Short, Aaron R; Koralla, Deepthi; Deshmukh, Ameya; Wissel, Benjamin; Stocker, Benjamin; Calhoun, Mark; Dean, David; Winter, Jessica O

2015-10-28

Bone defects can originate from a variety of causes, including trauma, cancer, congenital deformity, and surgical reconstruction. Success of the current "gold standard" treatment (i.e., autologous bone grafts) is greatly influenced by insufficient or inappropriate bone stock. There is thus a critical need for the development of new, engineered materials for bone repair. This review describes the use of natural and synthetic hydrogels as scaffolds for bone tissue engineering. We discuss many of the advantages that hydrogels offer as bone repair materials, including their potential for osteoconductivity, biodegradability, controlled growth factor release, and cell encapsulation. We also discuss the use of hydrogels in composite devices with metals, ceramics, or polymers. These composites are useful because of the low mechanical moduli of hydrogels. Finally, the potential for thermosetting and photo-cross-linked hydrogels as three-dimensionally (3D) printed, patient-specific devices is highlighted. Three-dimensional printing enables controlled spatial distribution of scaffold materials, cells, and growth factors. Hydrogels, especially natural hydrogels present in bone matrix, have great potential to augment existing bone tissue engineering devices for the treatment of critical size bone defects.

Role of DNA repair in repair of cytogenetic damages. Contribution of repair of single-strand DNA breaks to cytogenetic damages repair

International Nuclear Information System (INIS)

Rozanova, O.M.; Zaichkina, S.I.; Aptikaev, G.F.; Ganassi, E.Eh.

1989-01-01

The comparison was made between the results of the effect of poly(ADP-ribosylation) ingibitors (e.g. nicotinamide and 3-aminobenzamide) and a chromatin proteinase ingibitor, phenylmethylsulfonylfluoride, on the cytogenetic damages repair, by a micronuclear test, and DNA repair in Chinese hamster fibroblasts. The values of the repair half-periods (5-7 min for the cytogenetic damages and 5 min for the rapidly repaired DNA damages) and a similar modyfying effect with regard to radiation cytogenetic damages and kynetics of DNA damages repair were found to be close. This confirms the contribution of repair of DNA single-strand breaks in the initiation of structural damages to chromosomes

Ergonomics, Engineering, and Business: Repairing a Tricky Divorce

DEFF Research Database (Denmark)

Jensen, Per Langaa; Broberg, Ole; Møller, Niels

2009-01-01

This paper discusses how the ergonomics community can contribute to make ergonomics a strategic element in business decisions on strategy and implementation of strategy. The ergonomics community is seen as a heterogeneous entity made up of educational and research activities in universities......, ergonomists and engineers with ergonomic skills, professional ergonomics and engineering societies, and the complex of occupational health and safety regulation. This community interacts in different ways with companies and hereby influences how companies are dealing with ergonomics. The paper argues...

Internal audit of costs on fixed assets repair

Directory of Open Access Journals (Sweden)

M.Yu. Samchyk

2016-12-01

Full Text Available The article focuses on the approaches to the process and methods of expenditure audit on repair and modernization of fixed assets and the author considers that there is no single approach to understanding the issue. The author improves the organizational and methodological support of internal audit of expenditures on the fixed assets repair and modernization that forms the accurate information for management repair and modernization of fixed assets. The paper specifies the goals and objectives of internal expenditures on repair and modernization of fixed assets, depending on the sources of such facilities to the company, allowing the author to determine the documentary control methods to be applied by an auditor to perform each task. The article determines the areas of risk components of internal control that can lead to ineffective implementation of authority by officials of an enterprise in the process of fixed assets repair, which can cause inefficient use of resources and, consequently, decrease in the efficiency of the work of fixed assets repair and modernization. The author proposes the list of auditor’s questions to assess the internal control system in the repair of fixed assets and these questions will help identify the significant drawbacks of control means.

DNA repair

International Nuclear Information System (INIS)

Setlow, R.

1978-01-01

Some topics discussed are as follows: difficulty in extrapolating data from E. coli to mammalian systems; mutations caused by UV-induced changes in DNA; mutants deficient in excision repair; other postreplication mechanisms; kinds of excision repair systems; detection of repair by biochemical or biophysical means; human mutants deficient in repair; mutagenic effects of UV on XP cells; and detection of UV-repair defects among XP individuals

Rib fracture repair: indications, technical issues, and future directions.

Science.gov (United States)

Nirula, Raminder; Diaz, Jose J; Trunkey, Donald D; Mayberry, John C

2009-01-01

Rib fracture repair has been performed at selected centers around the world for more than 50 years; however, the operative indications have not been established and are considered controversial. The outcome of a strictly nonoperative approach may not be optimal. Potential indications for rib fracture repair include flail chest, painful, movable rib fractures refractory to conventional pain management, chest wall deformity/defect, rib fracture nonunion, and during thoracotomy for other traumatic indication. Rib fracture repair is technically challenging secondary to the human rib's relatively thin cortex and its tendency to fracture obliquely. Nonetheless, several effective repair systems have been developed. Future directions for progress on this important surgical problem include the development of minimally invasive techniques and the conduct of multicenter, randomized trials.

Management of 220 adolescents and adults with complications of hypospadias repair during childhood

Directory of Open Access Journals (Sweden)

Adam S. Howe

2017-01-01

Conclusion: Complications of childhood hypospadias repair may present later in life as some urethroplasties deteriorate with time. We now recommend to parents of children with repaired proximal hypospadias to come for follow-up as their child transitions to adolescence.

BUSINESS MANAGEMENT THEORY DEVELOPED ON THE BASIS OF SYSTEM APPROACH AND BUSINESS ENGINEERING TOOLS

Directory of Open Access Journals (Sweden)

N. I. Strich

2011-01-01

Full Text Available Management should be carried out with due account of the system theory and using tools and opportunities offered by such modern management components as business engineering and reengineering. Main points of this theory are given along with detailed determination of business engineering and reengineering particularly efficient while determining measures needed to reorganize an enterprise (or a group of enterprises through updating its organizational structure as well as economic, personnel or other system. Out-sourcing also described in detail is considered as modern enterprise management system’s most efficient instrument.

78 FR 9007 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

Science.gov (United States)

2013-02-07

... require, depending on the engine model, repetitive replacements of fuel injection manifolds and the... injection manifolds found during inspections at a repair workshop. We issued that AD to prevent engine... engines, initial and repetitive replacement of the fuel injection manifold and the privilege injector...

The essence of biophysical cues in skeletal muscle tissue engineering

NARCIS (Netherlands)

Langelaan, M.L.P.

2010-01-01

Skeletal muscle is an appealing topic for tissue engineering because of its variety in applications. Evidently, tissue engineered skeletal muscle can be used in the field of regenerative medicine to repair muscular defects or dystrophies. Engineered skeletal muscle constructs can also be used as a

DNA damage and gene therapy of xeroderma pigmentosum, a human DNA repair-deficient disease

Energy Technology Data Exchange (ETDEWEB)

Dupuy, Aurélie [Laboratory of Genetic Instability and Oncogenesis UMR8200CNRS, Institut Gustave Roussy and University Paris-Sud, Villejuif (France); Sarasin, Alain, E-mail: alain.sarasin@gustaveroussy.fr [Laboratory of Genetic Instability and Oncogenesis UMR8200CNRS, Institut Gustave Roussy and University Paris-Sud, Villejuif (France); Service de Génétique, Institut Gustave Roussy (France)

2015-06-15

Graphical abstract: - Highlights: • Full correction of mutation in the XPC gene by engineered nucleases. • Meganucleases and TALENs are inhibited by 5-MeC for inducing double strand breaks. • Gene therapy of XP cells is possible using homologous recombination for DSB repair. - Abstract: Xeroderma pigmentosum (XP) is a genetic disease characterized by hypersensitivity to ultra-violet and a very high risk of skin cancer induction on exposed body sites. This syndrome is caused by germinal mutations on nucleotide excision repair genes. No cure is available for these patients except a complete protection from all types of UV radiations. We reviewed the various techniques to complement or to correct the genetic defect in XP cells. We, particularly, developed the correction of XP-C skin cells using the fidelity of the homologous recombination pathway during repair of double-strand break (DSB) in the presence of XPC wild type sequences. We used engineered nucleases (meganuclease or TALE nuclease) to induce a DSB located at 90 bp of the mutation to be corrected. Expression of specific TALE nuclease in the presence of a repair matrix containing a long stretch of homologous wild type XPC sequences allowed us a successful gene correction of the original TG deletion found in numerous North African XP patients. Some engineered nucleases are sensitive to epigenetic modifications, such as cytosine methylation. In case of methylated sequences to be corrected, modified nucleases or demethylation of the whole genome should be envisaged. Overall, we showed that specifically-designed TALE-nuclease allowed us to correct a 2 bp deletion in the XPC gene leading to patient's cells proficient for DNA repair and showing normal UV-sensitivity. The corrected gene is still in the same position in the human genome and under the regulation of its physiological promoter. This result is a first step toward gene therapy in XP patients.

DNA damage and gene therapy of xeroderma pigmentosum, a human DNA repair-deficient disease

International Nuclear Information System (INIS)

Dupuy, Aurélie; Sarasin, Alain

2015-01-01

Graphical abstract: - Highlights: • Full correction of mutation in the XPC gene by engineered nucleases. • Meganucleases and TALENs are inhibited by 5-MeC for inducing double strand breaks. • Gene therapy of XP cells is possible using homologous recombination for DSB repair. - Abstract: Xeroderma pigmentosum (XP) is a genetic disease characterized by hypersensitivity to ultra-violet and a very high risk of skin cancer induction on exposed body sites. This syndrome is caused by germinal mutations on nucleotide excision repair genes. No cure is available for these patients except a complete protection from all types of UV radiations. We reviewed the various techniques to complement or to correct the genetic defect in XP cells. We, particularly, developed the correction of XP-C skin cells using the fidelity of the homologous recombination pathway during repair of double-strand break (DSB) in the presence of XPC wild type sequences. We used engineered nucleases (meganuclease or TALE nuclease) to induce a DSB located at 90 bp of the mutation to be corrected. Expression of specific TALE nuclease in the presence of a repair matrix containing a long stretch of homologous wild type XPC sequences allowed us a successful gene correction of the original TG deletion found in numerous North African XP patients. Some engineered nucleases are sensitive to epigenetic modifications, such as cytosine methylation. In case of methylated sequences to be corrected, modified nucleases or demethylation of the whole genome should be envisaged. Overall, we showed that specifically-designed TALE-nuclease allowed us to correct a 2 bp deletion in the XPC gene leading to patient's cells proficient for DNA repair and showing normal UV-sensitivity. The corrected gene is still in the same position in the human genome and under the regulation of its physiological promoter. This result is a first step toward gene therapy in XP patients

Through-life engineering services motivation, theory, and practice

CERN Document Server

Roy, Rajkumar

2015-01-01

Demonstrating the latest research and analysis in the area of through-life engineering services (TES), this book utilizes case studies and expert analysis from an international array of practitioners and researchers – who together represent multiple manufacturing sectors: aerospace, railway and automotive – to maximize reader insights into the field of through-life engineering services. As part of the EPSRC Centre in Through-life Engineering Services program to support the academic and industrial community, this book presents an overview of non-destructive testing techniques and applications and provides the reader with the information needed to assess degradation and possible automation of through-life engineering service activities . The latest developments in maintenance-repair-overhaul (MRO) are presented with emphasis on cleaning technologies, repair and overhaul approaches and planning and digital assistance. The impact of these technologies on sustainable enterprises is also analyzed. This book wil...

Special training of craftsmen for maintenance and repair

International Nuclear Information System (INIS)

Scholz, H.E.

1981-01-01

The most important prerequisites for keeping nuclear power plants running safely and consistently are the reliable plant supervision and control by operators and shift engineers and its permanent servicing and maintenance as well as the performance of qualified repair work. Therefore, sophisticated training of qualified labour in the fields of mechanical engineering, electrical engineering and instrumentation and control is as important as of operators and shift engineers. The objectives of the relevant training measures for the personnel mentioned above are: Acquisition of solid basic skills in the respective professions, development of a broad background in how nuclear power plants are designed and function, gaining a sound insight into the working procedures in nuclear power plants, maintenance planning, duties and responsibilities of personnel involved, and acquiring thorough knowledge of the systems and its components, the assigned staff will be responsible for. (orig./RW)

DATA MANAGEMENT PLANNING IN ENGINEERING DESIGN AND MANUFACTURING RESEARCH

DEFF Research Database (Denmark)

Darlington, Mansur; Howard, Thomas J.; Ball, Alex

2011-01-01

of research data and of the barriers to and opportunities for their re-use. The work reported here characterizes engineering design and manufacture research data and explores the context of their development and current management. Insights from the work have resulted in the authors proposing a number of new...

Goal-Function Tree Modeling for Systems Engineering and Fault Management

Science.gov (United States)

Johnson, Stephen B.; Breckenridge, Jonathan T.

2013-01-01

The draft NASA Fault Management (FM) Handbook (2012) states that Fault Management (FM) is a "part of systems engineering", and that it "demands a system-level perspective" (NASAHDBK- 1002, 7). What, exactly, is the relationship between systems engineering and FM? To NASA, systems engineering (SE) is "the art and science of developing an operable system capable of meeting requirements within often opposed constraints" (NASA/SP-2007-6105, 3). Systems engineering starts with the elucidation and development of requirements, which set the goals that the system is to achieve. To achieve these goals, the systems engineer typically defines functions, and the functions in turn are the basis for design trades to determine the best means to perform the functions. System Health Management (SHM), by contrast, defines "the capabilities of a system that preserve the system's ability to function as intended" (Johnson et al., 2011, 3). Fault Management, in turn, is the operational subset of SHM, which detects current or future failures, and takes operational measures to prevent or respond to these failures. Failure, in turn, is the "unacceptable performance of intended function." (Johnson 2011, 605) Thus the relationship of SE to FM is that SE defines the functions and the design to perform those functions to meet system goals and requirements, while FM detects the inability to perform those functions and takes action. SHM and FM are in essence "the dark side" of SE. For every function to be performed (SE), there is the possibility that it is not successfully performed (SHM); FM defines the means to operationally detect and respond to this lack of success. We can also describe this in terms of goals: for every goal to be achieved, there is the possibility that it is not achieved; FM defines the means to operationally detect and respond to this inability to achieve the goal. This brief description of relationships between SE, SHM, and FM provide hints to a modeling approach to

Development and validation of bonded composite doubler repairs for commercial aircraft.

Energy Technology Data Exchange (ETDEWEB)

Roach, Dennis Patrick; Rackow, Kirk A.

2007-07-01

A typical aircraft can experience over 2,000 fatigue cycles (cabin pressurizations) and even greater flight hours in a single year. An unavoidable by-product of aircraft use is that crack, impact, and corrosion flaws develop throughout the aircraft's skin and substructure elements. Economic barriers to the purchase of new aircraft have placed even greater demands on efficient and safe repair methods. The use of bonded composite doublers offers the airframe manufacturers and aircraft maintenance facilities a cost effective method to safely extend the lives of their aircraft. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is now possible to bond a single Boron-Epoxy composite doubler to the damaged structure. The FAA's Airworthiness Assurance Center at Sandia National Labs (AANC), Boeing, and Federal Express completed a pilot program to validate and introduce composite doubler repair technology to the U.S. commercial aircraft industry. This project focused on repair of DC-10 fuselage structure and its primary goal was to demonstrate routine use of this repair technology using niche applications that streamline the design-to-installation process. As composite doubler repairs gradually appear in the commercial aircraft arena, successful flight operation data is being accumulated. These commercial aircraft repairs are not only demonstrating the engineering and economic advantages of composite doubler technology but they are also establishing the ability of commercial maintenance depots to safely adopt this repair technique. This report presents the array of engineering activities that were completed in order to make this technology available for widespread commercial aircraft use. Focused laboratory testing was conducted to compliment the field data and to address specific issues regarding damage tolerance and flaw growth in composite doubler repairs. Fatigue and strength tests were performed on a simulated wing

Career Management for Scientists and Engineers

Science.gov (United States)

Borchardt, John K.

2000-05-01

This book will be an important resource for both new graduates and mid-career scientists, engineers, and technicians. Through taking stock of existing or desired skills and goals, it provides both general advice and concrete examples to help asses a current job situation or prospect, and to effectively pursue and attain new ones. Many examples of properly adapted resumes and interview techniques, as well as plenty of practical advice about adaptation to new workplace cultural paradigms, such as team-based management, make this book an invaluable reference for the professional scientist in today's volatile job market.

Chorioamniotic membrane separation and preterm premature rupture of membranes complicating in utero myelomeningocele repair.

Science.gov (United States)

Soni, Shelly; Moldenhauer, Julie S; Spinner, Susan S; Rendon, Norma; Khalek, Nahla; Martinez-Poyer, Juan; Johnson, Mark P; Adzick, N Scott

2016-05-01

Since the results of the Management of Myelomeningocele Study were published, maternal-fetal surgery for the in utero treatment of spina bifida has become accepted as a standard of care alternative. Despite promise with fetal management of myelomeningocele repair, there are significant complications to consider. Chorioamniotic membrane separation and preterm premature rupture of membranes are known complications of invasive fetal procedures. Despite their relative frequency associated with fetal procedures, few data exist regarding risk factors that may be attributed to their occurrence or the natural history of pregnancies that are affected with chorionic membrane separation or preterm premature rupture of membranes related to the procedure. The objective of this study was to review chorioamniotic membrane separation and preterm premature rupture of membranes in a cohort of patients undergoing fetal management of myelomeningocele repair including identification of risk factors and outcomes. This was a retrospective review of patients undergoing fetal management of myelomeningocele repair and subsequent delivery from January 2011 through December 2013 at 1 institution. Patients were identified through the institutional fetal management of myelomeningocele repair database and chart review was performed. Perioperative factors and outcomes among patients with chorioamniotic membrane separation and preterm premature rupture of membranes were compared to those without. Risk factors associated with the development of chorioamniotic membrane separation and preterm premature rupture of membranes were determined. A total of 88 patients underwent fetal management of myelomeningocele repair and subsequently delivered during the study period. In all, 21 patients (23.9%) were diagnosed with chorioamniotic membrane separation by ultrasound and preterm premature rupture of membranes occurred in 27 (30.7%). Among the chorioamniotic membrane separation patients, 10 (47.6%) were

Tissue-engineering as an adjunct to pelvic reconstructive surgery

DEFF Research Database (Denmark)

Jangö, Hanna

of pelvic organ prolapse (POP) are warranted. Traditional native tissue repair may be associated with poor long-term outcome and augmentation with permanent polypropylene meshes is associated with frequent and severe adverse effects. Tissue-engineering is a regenerative strategy that aims at creating...... functional tissue using stem cells, scaffolds and trophic factors. The aim of this thesis was to investigate the potential adjunctive use of a tissue-engineering technique for pelvic reconstructive surgery using two synthetic biodegradable materials; methoxypolyethyleneglycol-poly(lactic-co-glycolic acid......) (MPEG-PLGA) and electrospun polycaprolactone (PCL) - with or without seeded muscle stem cells in the form of autologous fresh muscle fiber fragments (MFFs).To simulate different POP repair scenarios different animal models were used. In Study 1 and 2, MPEG-PLGA was evaluated in a native tissue repair...

The Application of Tissue Engineering Procedures to Repair the Larynx

Science.gov (United States)

Ringel, Robert L.; Kahane, Joel C.; Hillsamer, Peter J.; Lee, Annie S.; Badylak, Stephen F.

2006-01-01

The field of tissue engineering/regenerative medicine combines the quantitative principles of engineering with the principles of the life sciences toward the goal of reconstituting structurally and functionally normal tissues and organs. There has been relatively little application of tissue engineering efforts toward the organs of speech, voice,…

Postgraduate Programmes on Environmental Water Resources Engineering and Management in Greek Universities

Science.gov (United States)

Latinopoulos, Pericles; Angelidis, Panagiotis

2014-01-01

The management of complex water problems is nowadays being practised through new ways and approaches. Therefore, water engineers, planners and managers should be appropriately educated through modern undergraduate curricula and by well-designed postgraduate specialisation programmes. Within this framework, a study of the specific characteristics…

On Obtaining Design Allowables for Adhesives Used in the Bonded-Composite Repair of Aircraft

National Research Council Canada - National Science Library

Chalkley, Peter

1998-01-01

A technique is documented, along with its experimental validation, for obtaining engineering-standard design allowables for structural adhesives used in the bonded/composite repair of aircraft structure...

Governing and Managing Customer-initiated Engineering Change – An in-depth case study of a global industrial supplier

DEFF Research Database (Denmark)

Sommer, Anita Friis; Storbjerg, Simon Haahr; Dukovska-Popovska, Iskra

2013-01-01

or externally by for instance customers. Managing initiated engineering changes is a vital source for improving product performance and radically reducing change costs. Customer-initiated engineering change is an area growing in importance decreasing product life cycles and increasing demand for customisation....... Through an in-depth case study, this paper investigates which process and what governance setup is appropriate to manage customer initiated engineering changes, referred to as request management. The paper includes a proposal for a request management framework and a task-based iterative process model...

Management Science/Industrial Engineering Techniques to Reduce Food Costs.

Science.gov (United States)

Greenberg, Murray

This paper examines the contributions of Industrial Engineering and Management Science toward reduction in the cost of production and distribution of food. Food processing firms were requested to respond to a questionnaire which asked for examples of their use of various operations research tools and information on the number of operations…

Department of Energy environmental management complex-wide integration using systems engineering

International Nuclear Information System (INIS)

Fairbourn, P.

1997-01-01

A systems engineering approach was successfully used to recommend changes to environmental management activities across the DOE Complex. A team of technical experts and systems engineers developed alternatives that could save tax payers billions of dollars if the barriers are removed to allow complete implementation. The alternatives are technically-based and defensible, and are being worked through the stakeholder review process. The integration process and implementing project structure are both discussed

Sustainable solid waste management a systems engineering approach

CERN Document Server

Chang, N

2015-01-01

Interactions between human activities and the environment are complicated and often difficult to quantify. In many occasions, judging where the optimal balance should lie among environmental protection, social well-being, economic growth, and technological progress is complex. The use of a systems engineering approach will fill in the gap contributing to how we understand the intricacy by a holistic way and how we generate better sustainable solid waste management practices. This book aims to advance interdisciplinary understanding of intertwined facets between policy and technology relevant to solid waste management issues interrelated to climate change, land use, economic growth, environmental pollution, industrial ecology, and population dynamics.

Teaching Tip: Managing Software Engineering Student Teams Using Pellerin's 4-D System

Science.gov (United States)

Doman, Marguerite; Besmer, Andrew; Olsen, Anne

2015-01-01

In this article, we discuss the use of Pellerin's Four Dimension Leadership System (4-D) as a way to manage teams in a classroom setting. Over a 5-year period, we used a modified version of the 4-D model to manage teams within a senior level Software Engineering capstone course. We found that this approach for team management in a classroom…

Development of a Remote External Repair Tool for Damaged or Defective Polyethylene Pipe

Energy Technology Data Exchange (ETDEWEB)

Kenneth H. Green; Willie E. Rochefort; Nick Wannenmacher; John A. Clark; Kevin Harris

2006-06-30

Current procedures for repairing polyethylene (PE) gas pipe require excavation, isolation, and removal of the damaged section of pipe followed by fusing a new section of pipe into place. These techniques are costly and very disruptive. An alternative repair method was developed at Timberline Tool with support from Oregon State University (OSU) and funding by the U. S. Department of Energy National Energy Technology Laboratory (DOE/NETL). This project was undertaken to design, develop and test a tool and method for repairing damaged PE pipe remotely and externally in situ without squeezing off the flow of gas, eliminating the need for large-scale excavations. Through an iterative design and development approach, a final engineered prototype was developed that utilizes a unique thermo-chemical and mechanical process to apply a permanent external patch to repair small nicks, gouges and punctures under line pressure. The project identified several technical challenges during the design and development process. The repair tool must be capable of being installed under live conditions and operate in an 18-inch keyhole. This would eliminate the need for extensive excavations thus reducing the cost of the repair. Initially, the tool must be able to control the leak by encapsulating the pipe and apply slight pressure at the site of damage. Finally, the repair method must be permanent at typical operating pressures. The overall results of the project have established a permanent external repair method for use on damaged PE gas pipe in a safe and cost-effective manner. The engineered prototype was subjected to comprehensive testing and evaluation to validate the performance. Using the new repair tool, samples of 4-inch PE pipe with simulated damage were successfully repaired under line pressure to the satisfaction of DOE/NETL and the following natural gas companies: Northwest Natural; Sempra Energy, Southwest Gas Corporation, Questar, and Nicor. However, initial results of

ENGINEERING INSIDE PROCESS OF URBAN RENEWAL AND COMMUNITY MANAGEMENT

Directory of Open Access Journals (Sweden)

Barrantes, K.

2015-06-01

Full Text Available This paper aims to show the community management process and interdisciplinary work involve in the Social Action project named “University social work: Calle de la Amargura towards a physical, recreational and cultural renewal” which belongs to the Civil Engineering School of Universidad de Costa Rica (UCR This initiative began in 2005 as a response to the security issue in a place known as “Calle de la Amargura”, in Costa Rica, this street has been stigmatized as an unsafe and damaged spot. Even though, this place has a negative concept, it has a huge urban potential as a meeting point for youth; this, due to closeness to Universidad de Costa Rica. Nevertheless, situations as drugs dealing and violence have created a negative perception within people all around the country. This project of urban renewal since the beginning has sought to enhance the perception of “Calle de la Amargura” from three axes: the development of educational and leisure activities, the foundation of community working networks and the improvement of physical conditions. Interdisciplinary groups were created in different areas such as engineer, arts, social sciences, health and education. Today, this plan is a recognize project, which involves a hard work on public space appropriation. Indeed, this paper seeks to expose the high content of social action and community management process of urban renewal leading by Engineering Faculty

Cartilage repair in the degenerative ageing knee

Science.gov (United States)

Brittberg, Mats; Gomoll, Andreas H; Canseco, José A; Far, Jack; Lind, Martin; Hui, James

2016-01-01

Background and purpose Cartilage damage can develop due to trauma, resulting in focal chondral or osteochondral defects, or as more diffuse loss of cartilage in a generalized organ disease such as osteoarthritis. A loss of cartilage function and quality is also seen with increasing age. There is a spectrum of diseases ranging from focal cartilage defects with healthy surrounding cartilage to focal lesions in degenerative cartilage, to multiple and diffuse lesions in osteoarthritic cartilage. At the recent Aarhus Regenerative Orthopaedics Symposium (AROS) 2015, regenerative challenges in an ageing population were discussed by clinicians and basic scientists. A group of clinicians was given the task of discussing the role of tissue engineering in the treatment of degenerative cartilage lesions in ageing patients. We present the outcomes of our discussions on current treatment options for such lesions, with particular emphasis on different biological repair techniques and their supporting level of evidence. Results and interpretation Based on the studies on treatment of degenerative lesions and early OA, there is low-level evidence to suggest that cartilage repair is a possible treatment for such lesions, but there are conflicting results regarding the effect of advanced age on the outcome. We concluded that further improvements are needed for direct repair of focal, purely traumatic defects before we can routinely use such repair techniques for the more challenging degenerative lesions. Furthermore, we need to identify trigger mechanisms that start generalized loss of cartilage matrix, and induce subchondral bone changes and concomitant synovial pathology, to maximize our treatment methods for biological repair in degenerative ageing joints. PMID:27910738

Application of Interfacial Propagation and Kinking Crack Concept to ECC/Concrete Overlay Repair System

Directory of Open Access Journals (Sweden)

Yaw ChiaHwan

2014-01-01

Full Text Available Research on the application of ultraductile engineered cementitious composite (ECC as overlay in the repair of deteriorated concrete structures is performed in this paper. Also, interfacial crack kinking and trapping mechanism experimentally observed in ECC/concrete overlay repair system are described by comparison of toughness and energy release rate. The mechanism involves cycles of extension, kinking, and arrest of interfacial crack into the overlay. Experimental testing of overlay repair system reveals significant improvements in load carrying capacity and ductility over conventional concrete overlay. The commonly observed overlay system failure mode of delamination or spalling is eliminated when ECC is applied. These failure modes are suppressed when ECC is used as an ideal and durable candidate overlay repair material.

Knowledge management through the e-learning approach - a case study of online engineering courses

Science.gov (United States)

Aichouni, Mohamed; Benchicou, Soraya; Nehari, Dris

2013-06-01

Though it is universally accepted that the face-to-face approach is the best way for education and training, however, with the advent of the information and communication technologies (mainly the World Wide Web) it became possible to enhance further the methods we are using to teach our students and to share the teaching material within a broaden engineering, technical and business communities. This paper is dedicated to making a review of the basic concepts of knowledge management and e-learning and to show how these two modern concepts can be integrated into engineering education to produce knowledge, disseminate it and share it within virtual interest groups and networks of engineering students, academic teachers and industrial engineers and technicians and business managers. A practical case study will be presented and discussed.

Primary repair of penetrating colon injuries: a systematic review.

Science.gov (United States)

Singer, Marc A; Nelson, Richard L

2002-12-01

Primary repair of penetrating colon injuries is an appealing management option; however, uncertainty about its safety persists. This study was conducted to compare the morbidity and mortality of primary repair with fecal diversion in the management of penetrating colon injuries by use of a meta-analysis of randomized, prospective trials. We searched for prospective, randomized trials in MEDLINE (1966 to November 2001), the Cochrane Library, and EMBase using the terms colon, penetrating, injury, colostomy, prospective, and randomized. Studies were included if they were randomized, controlled trials that compared the outcomes of primary repair with fecal diversion in the management of penetrating colon injuries. Five studies were included. Reviewers performed data extraction independently. Outcomes evaluated from each trial included mortality, total complications, infectious complications, intra-abdominal infections, wound complications, penetrating abdominal trauma index, and length of stay. Peto odds ratios for combined effect were calculated with a 95 percent confidence interval for each outcome. Heterogeneity was also assessed for each outcome. The penetrating abdominal trauma index of included subjects did not differ significantly between studies. Mortality was not significantly different between groups (odds ratio, 1.70; 95 percent confidence interval, 0.51-5.66). However, total complications (odds ratio, 0.28; 95 percent confidence interval, 0.18-0.42), total infectious complications (odds ratio, 0.41; 95 percent confidence interval, 0.27-0.63), abdominal infections including dehiscence (odds ratio, 0.59; 95 percent confidence interval, 0.38-0.94), abdominal infections excluding dehiscence (odds ratio, 0.52; 95 percent confidence interval, 0.31-0.86), wound complications including dehiscence (odds ratio, 0.55; 95 percent confidence interval, 0.34-0.89), and wound complications excluding dehiscence (odds ratio, 0.43; 95 percent confidence interval, 0

Integration of CATIA/Smarteam into CERN's corporate engineering data management system

CERN Document Server

Hakulinen, Timo; Friman, Per Olof; Pettersson, Thomas Sven; Van Uytvinck, E; Widegren, David; Fournier, G

2008-01-01

We present a short overview of the strategy defined to integrate the 3D CAD system CATIA/Smarteam into CERN's corporate Engineering and Equipment Data Management System (EDMS), which is used to manage the information about the Laboratory's installations and technical infrastructure. A brief description of the existing EDMS architecture is given, describing the available project life cycle management features, including CATIA/Smarteam. An overview of the design office requirements on the new CAD system is also presented.

CrowdAidRepair: A Crowd-Aided Interactive Data Repairing Method

KAUST Repository

Zhou, Jian

2016-03-25

Data repairing aims at discovering and correcting erroneous data in databases. Traditional methods relying on predefined quality rules to detect the conflict between data may fail to choose the right way to fix the detected conflict. Recent efforts turn to use the power of crowd in data repairing, but the crowd power has its own drawbacks such as high human intervention cost and inevitable low efficiency. In this paper, we propose a crowd-aided interactive data repairing method which takes the advantages of both rule-based method and crowd-based method. Particularly, we investigate the interaction between crowd-based repairing and rule-based repairing, and show that by doing crowd-based repairing to a small portion of values, we can greatly improve the repairing quality of the rule-based repairing method. Although we prove that the optimal interaction scheme using the least number of values for crowd-based repairing to maximize the imputation recall is not feasible to be achieved, still, our proposed solution identifies an efficient scheme through investigating the inconsistencies and the dependencies between values in the repairing process. Our empirical study on three data collections demonstrates the high repairing quality of CrowdAidRepair, as well as the efficiency of the generated interaction scheme over baselines.

Computer security engineering management

International Nuclear Information System (INIS)

McDonald, G.W.

1988-01-01

For best results, computer security should be engineered into a system during its development rather than being appended later on. This paper addresses the implementation of computer security in eight stages through the life cycle of the system; starting with the definition of security policies and ending with continuing support for the security aspects of the system throughout its operational life cycle. Security policy is addressed relative to successive decomposition of security objectives (through policy, standard, and control stages) into system security requirements. This is followed by a discussion of computer security organization and responsibilities. Next the paper directs itself to analysis and management of security-related risks, followed by discussion of design and development of the system itself. Discussion of security test and evaluation preparations, and approval to operate (certification and accreditation), is followed by discussion of computer security training for users is followed by coverage of life cycle support for the security of the system

State of the Art : Integrated Management of Requirements in Model-Based Software Engineering

OpenAIRE

Thörn, Christer

2006-01-01

This report describes the background and future of research concerning integrated management of requirements in model-based software engineering. The focus is on describing the relevant topics and existing theoretical backgrounds that form the basis for the research. The report describes the fundamental difficulties of requirements engineering for software projects, and proposes that the results and methods of models in software engineering can help leverage those problems. Taking inspiration...

Tissue engineering in dentistry.

Science.gov (United States)

Abou Neel, Ensanya Ali; Chrzanowski, Wojciech; Salih, Vehid M; Kim, Hae-Won; Knowles, Jonathan C

2014-08-01

of this review is to inform practitioners with the most updated information on tissue engineering and its potential applications in dentistry. The authors used "PUBMED" to find relevant literature written in English and published from the beginning of tissue engineering until today. A combination of keywords was used as the search terms e.g., "tissue engineering", "approaches", "strategies" "dentistry", "dental stem cells", "dentino-pulp complex", "guided tissue regeneration", "whole tooth", "TMJ", "condyle", "salivary glands", and "oral mucosa". Abstracts and full text articles were used to identify causes of craniofacial tissue loss, different approaches for craniofacial reconstructions, how the tissue engineering emerges, different strategies of tissue engineering, biomaterials employed for this purpose, the major attempts to engineer different dental structures, finally challenges and future of tissue engineering in dentistry. Only those articles that dealt with the tissue engineering in dentistry were selected. There have been a recent surge in guided tissue engineering methods to manage periodontal diseases beyond the traditional approaches. However, the predictable reconstruction of the innate organisation and function of whole teeth as well as their periodontal structures remains challenging. Despite some limited progress and minor successes, there remain distinct and important challenges in the development of reproducible and clinically safe approaches for oral tissue repair and regeneration. Clearly, there is a convincing body of evidence which confirms the need for this type of treatment, and public health data worldwide indicates a more than adequate patient resource. The future of these therapies involving more biological approaches and the use of dental tissue stem cells is promising and advancing. Also there may be a significant interest of their application and wider potential to treat disorders beyond the craniofacial region. Considering the