3D printing with RepRap cookbook

CERN Document Server

Salinas, Richard

2014-01-01

A systematic guide consisting of over 100 recipes which focus on helping you understand the process of 3D printing using RepRap machines. The book aims at providing professionals with a series of working recipes to help make their fuzzy notions into real, saleable projects/objects using 3D printing technology. This book is for novice designers and artists who own a RepRap-based 3D printer, have fundamental knowledge of its working, and who desire to gain better mastery of the printing process. For the more experienced user, it will provide a handy visual resource, with side-by-side comparisons

Regulation and drive system for high rep-rate magnetic-pulse compressors

International Nuclear Information System (INIS)

Birx, D.L.; Cook, E.G.; Hawkins, S.; Meyers, A.; Reginato, L.L.; Schmidt, J.A.; Smith, M.W.

1982-01-01

The essentially unlimited rep-rate capability of non-linear magnetic systems has imposed strict requirements on the drive system which initiates the pulse compression. An order of magnitude increase in the rep-rates achieved by the Advanced Test Accelerator (ATA) gas blown system is not difficult to achieve in the magnetic compressor. The added requirement of having a high degree of regulation at the higher rep-rates places strict requirements on the triggerable switch for charging and de-Queing. A novel feedback technique which applies the proper bias to a magnetic core by comparing a reference voltage to the charging voltage eases considerably the regulation required to achieve low jitter in magnetic compression. The performance of the high rep-rate charging and regulation systems will be described in the following pages

Deformable M-Reps for 3D Medical Image Segmentation

Science.gov (United States)

Pizer, Stephen M.; Fletcher, P. Thomas; Joshi, Sarang; Thall, Andrew; Chen, James Z.; Fridman, Yonatan; Fritsch, Daniel S.; Gash, Graham; Glotzer, John M.; Jiroutek, Michael R.; Lu, Conglin; Muller, Keith E.; Tracton, Gregg; Yushkevich, Paul; Chaney, Edward L.

2013-01-01

M-reps (formerly called DSLs) are a multiscale medial means for modeling and rendering 3D solid geometry. They are particularly well suited to model anatomic objects and in particular to capture prior geometric information effectively in deformable models segmentation approaches. The representation is based on figural models, which define objects at coarse scale by a hierarchy of figures – each figure generally a slab representing a solid region and its boundary simultaneously. This paper focuses on the use of single figure models to segment objects of relatively simple structure. A single figure is a sheet of medial atoms, which is interpolated from the model formed by a net, i.e., a mesh or chain, of medial atoms (hence the name m-reps), each atom modeling a solid region via not only a position and a width but also a local figural frame giving figural directions and an object angle between opposing, corresponding positions on the boundary implied by the m-rep. The special capability of an m-rep is to provide spatial and orientational correspondence between an object in two different states of deformation. This ability is central to effective measurement of both geometric typicality and geometry to image match, the two terms of the objective function optimized in segmentation by deformable models. The other ability of m-reps central to effective segmentation is their ability to support segmentation at multiple levels of scale, with successively finer precision. Objects modeled by single figures are segmented first by a similarity transform augmented by object elongation, then by adjustment of each medial atom, and finally by displacing a dense sampling of the m-rep implied boundary. While these models and approaches also exist in 2D, we focus on 3D objects. The segmentation of the kidney from CT and the hippocampus from MRI serve as the major examples in this paper. The accuracy of segmentation as compared to manual, slice-by-slice segmentation is reported. PMID

Molecular characterization of Salmonella isolates by REP-PCR and RAPD analysis.

Science.gov (United States)

Albufera, U; Bhugaloo-Vial, P; Issack, M I; Jaufeerally-Fakim, Y

2009-05-01

Eighteen Salmonella isolates from both human and food (non-human) sources (fish, meat, and poultry) were characterized using conventional culture methods, biochemical, serological, and molecular analyses. REP-PCR and RAPD produced DNA profiles for differentiation purposes. Enterobacterial repetitive intergenic consensus (ERIC), repetitive extragenic palindronic (REP) and BOXAIR primers were selected for REP-PCR and two arbitrary primers, namely OPP-16 and OPS-11 were used for RAPD to generate DNA fingerprints from the Salmonella isolates. REP-PCR method showed greater discriminatory power in differentiating closely related strains of the related strains of Salmonella and produced more complex banding patterns as compared with RAPD. A dendogram was constructed with both sets of profiles using SPSS Version 13.0 computer software and showed that most human isolates were separately clustered from the non-human isolates. Two of the human isolates were closely related to some of the non-human isolates. A good correlation was also observed between the serogrouping of the O antigen and the molecular profiles obtained from REP-PCR and RAPD data of the Salmonella isolates. The results of a principal coordinate analysis (PCA) corresponded to the clustering in the dendrogram.

Expression, purification, characterization and subcellular localization of the goose parvovirus rep1 protein.

Science.gov (United States)

Chen, Zongyan; Li, Chuanfeng; Peng, Gaojing; Liu, Guangqing

2013-07-01

The goose parvovirus (GPV) Rep1 protein is both essential for viral replication and a potential target for GPV diagnosis, but its protein characterization and intracellular localization is not clear. We constructed a recombinant plasmid, pET28a/GPV-Rep1, and expressed the Rep1 gene in BL21 (DE3) Escherichia coli. A protein approximately 75 kDa in size was obtained from lysates of E. coli cells expressing the recombinant plasmid. SDS-PAGE analysis showed that after induction with 0.6 mM isopropyl β-D-thiogalactosidase (IPTG) at 30°C for 5 h, the Rep1 protein was highly overexpressed. Two methods used to purify proteins, a salinity-gradient elution and Ni-NTA affinity chromatography, were performed. The amount of Rep1 protein obtained by Ni-NTA affinity chromatography was 41.23 mg, while 119.9 mg of Rep1 protein was obtained by a salinity-gradient elution from a 1 L E. coli BL21 (DE3) culture. An immunogenicity analysis showed that the protein could significantly elicit a specific antibody response in immunized goslings compared to control groups. Antibody titers peaked to 1:5120 (optical density (OD) 450 = 3.9) on day 28 after immunization but had mean titers of 1:10,240 (OD450 = 4.2) in gosling groups immunized with a commercially available GPV-attenuated vaccine strain. Experiments examining subcellular localization showed that the Rep1 protein appeared to associate predominantly with the nuclear membrane, especially during later times of infection. This work provides a basis for biochemical and structural studies on the GPV Rep1 protein.

O ethos do repórter de TV da Rede Globo

Directory of Open Access Journals (Sweden)

Marcia Benetti

2017-05-01

Full Text Available O artigo analisa os elementos instituintes das imagens de si de repórteres de televisão da Rede Globo, maior emissora do Brasil. A partir do conceito de ethos discursivo, discutimos como o discurso autorreferente afirma a identidade do jornalista e certos efeitos de verdade a respeito da reportagem. Por meio da análise do discurso de cinco entrevistas de repórteres da Rede Globo concedidas à também jornalista Fátima Bernardes, propomos que o ethos do repórter constrói-se em três dimensões: os atributos do “bom jornalista”, as características do “bom repórter” e as particularidades de pertencimento ao campo jornalístico. Como articuladores do ethos, os valores morais e os aspectos relacionados às rotinas profissionais convocam a audiência a se conectar com certas definições sobre o jornalismo.

Images en mouvement stockage, repérage, indexation

CERN Document Server

Turner, James

1998-01-01

L'avènement puis la fusion des nouveaux modes de communication que sont l'informatique, les télécommunications et l'audiovisuel ont mis à la portée de tous une grande quantité d'images fixes et en mouvement dont la conservation et le repérage risquent de prendre des proportions démesurées. Le présent ouvrage veut offrir aux responsables de collection des repères pour aborder la problématique de l'indexation des images et faciliter l'accès des usagers à ces images.

Intracellular route and biological activity of exogenously delivered Rep proteins from the adeno-associated virus type 2

International Nuclear Information System (INIS)

Awedikian, Rafi; Francois, Achille; Guilbaud, Mickael; Moullier, Philippe; Salvetti, Anna

2005-01-01

The two large Rep proteins, Rep78 and Rep68, from the adeno-associated virus type 2 (AAV-2) are required for AAV-2 DNA replication, site-specific integration, and for the regulation of viral gene expression. The study of their activities is dependent on the ability to deliver these proteins to the cells in a time and dose-dependent manner. We evaluated the ability of a protein transduction domain (PTD) derived from the human immunodeficiency virus 1 (HIV-1) TAT protein to drive the cellular internalization of exogenously delivered PTD-fused Rep68 proteins. This analysis unexpectedly revealed that recombinant Rep68 alone, in the absence of any PTD, could be endocytosed by the cells. Rep68 as the chimeric TAT-Rep68 proteins were internalized through endocytosis in clathrin-coated vesicles and retained in late endosomes/lysosomes with no detectable nuclear localization. In the presence of adenovirus, the Rep proteins could translocate into the nucleus where they displayed a biological activity. These findings support recent reports on the mechanism of entry of TAT-fused proteins and also revealed a new property of Rep68

Typing of avian pathogenic Escherichia coli strains by REP-PCR Tipificação de amostras aviárias patogênicas de Escherichia coli pela REP-PCR

Directory of Open Access Journals (Sweden)

Marcelo Brocchi

2006-06-01

Full Text Available In the present study the repetitive extragenic palindromic (REP polymerase chain reaction (PCR technique was used to establish the clonal variability of 49 avian Escherichia coli (APEC strains isolated from different outbreak cases of septicemia (n=24, swollen head syndrome (n=14 and omphalitis (n=11. Thirty commensal strains isolated from poultry with no signs of these illnesses were used as control strains. The purified DNA of these strains produced electrophoretic profiles ranging from 0 to 15 bands with molecular sizes varying from 100 bp to 6.1 kb, allowing the grouping of the 79 strains into a dendrogram containing 49 REP-types. Although REP-PCR showed good discriminating power it was not able to group the strains either into specific pathogenic classes or to differentiate between pathogenic and non-pathogenic strains. On the contrary, we recently demonstrated that other techniques such as ERIC-PCR and isoenzyme profiles are appropriate to discriminate between commensal and APEC strains and also to group these strains into specific pathogenic classes. In conclusion, REP-PCR seems to be a technique neither efficient nor universal for APEC strains discrimination. However, the population clonal structure obtained with the use of REP-PCR must not be ignored particularly if one takes into account that the APEC pathogenic mechanisms are not completely understood yet.A técnica de REP (Repetitive extragenic palindrome-PCR foi utilizada para avaliar a variabilidade genética de 49 amostras de Escherichia coli patogênicas para aves (APEC, isoladas de aves de corte (frangos em diferentes surtos de septicemia (n=24, síndrome da cabeça inchada (n=14 e onfalite (n=11. Trinta amostras comensais, isoladas de frangos sem sinais de doença, foram utilizadas como controle. A análise do perfil eletroforético obtido por reação de REP-PCR utilizando DNA purificado das amostras evidenciou a amplificação de 0 a 15 bandas de DNA com pesos moleculares

Mailis Reips : Prezhde vsego neobhodimo natshat / Mailis Reps

Index Scriptorium Estoniae

Reps, Mailis, 1975-

2006-01-01

Haridusminister Mailis Reps kakskeelse hariduse vajalikkusest vene õppekeelega koolides, noorte keeleoskusest, eesti keele õpetamise kvaliteedist, õpetajate eesti keele oskusest, õppetöö kvaliteedist

Development of low-cost open source 3D gel printer "RepRap SWIM-ER"

Science.gov (United States)

Sato, Kei; Basher, Samiul; Ota, Takafumi; Tase, Taishi; Takamatsu, Kyuichiro; Saito, Azusa; Khosla, Ajit; Kawakami, Masaru; Furuawa, Hidemitsu

2017-04-01

Gels are soft and wet materials having low friction, good biocompatibility, and material permeability. It is expected that gel materials will be used as new kinds of industrial materials in the engineering and medical applications. But it cannot build a complicated shape. Soft & Wet Matter Engineering Laboratory developed a 3D gel Printer "SWIM-ER", has enabled modeling of complex shapes of the gel. However, this is expensive. Therefore not all of the gel researchers and the companies have such a device. To solve this problem, we manufacture a low-cost open-source 3D gel printer "RepRap SWIM-ER" from the RepRap. We made the components required to manufacture the "RepRap SWIM-ER" from the 3D printer and chose a light source. In addition, we produced the P-DN gel for RepRap SWIM-ER and conducted the molding test to confirm whether RepRap SWIM-ER can used it.

Firmino Costa, un intelectual de la República y sus propósitos educativos (1907-1937

Directory of Open Access Journals (Sweden)

Juliana Cesário Hamdan

2014-01-01

Full Text Available El presente artículo pretende analizar la actu - ación del educador Firmino Costa, nacido en Minas Gerais, al retomar sus antecedentes his - tóricos que se localizan en la base de las formas de su actuación política e intelectual. Para este análisis, recurrimos al trabajo de Alonso (2008, 1 Oliveira (1999 2 y Carvalho (2003, 3 considera - mos las expresivas contribuciones para su com - prensión en relación con la historia e ideas que circularon en este periodo, comprendido entre los años que antecedieron a las primeras déca - das de la Proclamación de la República en Brasil (I889. Las tres obras, pese a que se escribieron a partir de objetos y objetivos distintos, refuta - ron interpretaciones que, por un lado, tratan el escenario intelectual de la República por medio de tipologías de intelectuales, que estarían ab - sorbiendo pasivamente las teorías europeas y norteamericanas. Y, por otro lado, las que son marcadas por estudios que enfatizan las acciones individuales, empeñadas en llevar adelante sus banderas ideológicas. Al contrario, los autores entienden que los sujetos están inmersos en de - terminado entorno cultural, constituido por las redes de sociabilidad y por el repertorio de ideas en circulación y, por eso mismo, tienen formas distintas de actuación política e intelectual. Y ese escenario condiciona, en gran medida, las posi - bilidades de actuación. Así, este artículo busca establecer conexiones entre algunos elementos del escenario cultural, presentes en los años que antecedieron y en los que sucedieron a la República, relacionándolos a las formas de actuación política e intelectual que informan la acción educacional del educador minero. Ese movimiento analítico, por su vez, exigió que recorriésemos a algunas de las formu - laciones teóricas de Antonio Gramsci, en lo que se refiere a los sentidos de actuación de los inte - lectuales, como forma de comprenderlos a partir del contexto y de las

Democracia y República

OpenAIRE

Toledo, Víctor Fabio

2013-01-01

p. 33-34 En la actualidad se ha reavivado el debate en torno a los conceptos de Democracia y República. Desde el triunfo sobre el nazismo a mediados del siglo XX la democracia se ha constituido en un imperativo occidental y, a partir del derrumbe soviético, en uno cuasi universal. Sin embargo, en algunos casos —y no pocos por cierto— en el reclamo por la democratización se encontraron razones ideales para consagrar la concentración de los poderes del Estado, por paradójico que parezca. Es ...

Applications: REP-rate pulse power technology

International Nuclear Information System (INIS)

Anon.

1979-01-01

Research on the following topics is discussed: (1) REP-rate pulse power technology, (2) RTF-I, 300-J, 100-pps test facility experiments, (3) transformer development, (4) reactor system studies, (5) general conceptual design, (6) economic considerations, (7) specific reactor designs, (8) low-current density diode physics studies, and (9) plasma injected, microsecond, E-beam diodes

The Filament-specific Rep1-1 Repellent of the Phytopathogen Ustilago maydis Forms Functional Surface-active Amyloid-like Fibrils

NARCIS (Netherlands)

Teertstra, Wieke R.; van der Velden, Gisela J.; de Jong, Jan F.; Kruijtzer, John A. W.; Liskamp, Rob M. J.; Kroon-Batenburg, Loes M. J.; Muller, Wally H.; Gebbink, Martijn F. B. G.; Wosten, Han A. B.

2009-01-01

Repellents of the maize pathogen Ustilago maydis are involved in formation of hydrophobic aerial hyphae and in cellular attachment. These peptides, called Rep1-1 to Rep1-11, are encoded by the rep1 gene and result from cleavage of the precursor protein Rep1 during passage of the secretion pathway.

Production of propylene from 1-butene on highly active "bi-functional single active site" catalyst: Tungsten carbene-hydride supported on alumina

KAUST Repository

Mazoyer, Etienne

2011-12-02

1-Butene is transformed in a continuous flow reactor over tungsten hydrides precursor W-H/Al2O3, 1, giving a promising yield into propylene at 150 °C and different pressures. Tungsten carbene-hydride single active site operates as a "bi-functional catalyst" through 1-butene isomerization on W-hydride and 1-butene/2-butenes cross-metathesis on W-carbene. This active moiety is generated in situ at the initiation steps by insertion of 1-butene on tungsten hydrides precursor W-H/Al2O3, 1 followed by α-H and β-H abstraction. © 2011 American Chemical Society.

Evolution of REP diversity: a comparative study

Czech Academy of Sciences Publication Activity Database

Nunvář, Jaroslav; Lichá, I.; Schneider, Bohdan

2013-01-01

Roč. 14, č. 385 (2013) ISSN 1471-2164 R&D Projects: GA ČR GAP305/12/1801 Institutional research plan: CEZ:AV0Z50520701 Keywords : REP elements * Stenotrophomonas maltophilia * Pseudomonas fluorescens Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.041, year: 2013

A core hSSB1–INTS complex participates in the DNA damage response

OpenAIRE

Zhang, Feng; Ma, Teng; Yu, Xiaochun

2013-01-01

Human single-stranded DNA-binding protein 1 (hSSB1) plays an important role in the DNA damage response and the maintenance of genomic stability. It has been shown that the core hSSB1 complex contains hSSB1, INTS3 and C9orf80. Using protein affinity purification, we have identified integrator complex subunit 6 (INTS6) as a major subunit of the core hSSB1 complex. INTS6 forms a stable complex with INTS3 and hSSB1 both in vitro and in vivo. In this complex, INTS6 directly interacts with INTS3. I...

ReRep: Computational detection of repetitive sequences in genome survey sequences (GSS

Directory of Open Access Journals (Sweden)

Alves-Ferreira Marcelo

2008-09-01

Full Text Available Abstract Background Genome survey sequences (GSS offer a preliminary global view of a genome since, unlike ESTs, they cover coding as well as non-coding DNA and include repetitive regions of the genome. A more precise estimation of the nature, quantity and variability of repetitive sequences very early in a genome sequencing project is of considerable importance, as such data strongly influence the estimation of genome coverage, library quality and progress in scaffold construction. Also, the elimination of repetitive sequences from the initial assembly process is important to avoid errors and unnecessary complexity. Repetitive sequences are also of interest in a variety of other studies, for instance as molecular markers. Results We designed and implemented a straightforward pipeline called ReRep, which combines bioinformatics tools for identifying repetitive structures in a GSS dataset. In a case study, we first applied the pipeline to a set of 970 GSSs, sequenced in our laboratory from the human pathogen Leishmania braziliensis, the causative agent of leishmaniosis, an important public health problem in Brazil. We also verified the applicability of ReRep to new sequencing technologies using a set of 454-reads of an Escheria coli. The behaviour of several parameters in the algorithm is evaluated and suggestions are made for tuning of the analysis. Conclusion The ReRep approach for identification of repetitive elements in GSS datasets proved to be straightforward and efficient. Several potential repetitive sequences were found in a L. braziliensis GSS dataset generated in our laboratory, and further validated by the analysis of a more complete genomic dataset from the EMBL and Sanger Centre databases. ReRep also identified most of the E. coli K12 repeats prior to assembly in an example dataset obtained by automated sequencing using 454 technology. The parameters controlling the algorithm behaved consistently and may be tuned to the properties

The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins

DEFF Research Database (Denmark)

Madsen, Louise; Kriegenburg, Franziska; Lages Lino Vala, Andrea

2011-01-01

is a transmembrane protein that localizes to the ER membrane with its UBX domain facing the cytoplasm. Knock-down of Rep8 expression in human cells leads to a decreased association of p97 with the ER membrane and concomitantly a retarded degradation of misfolded ER-derived proteasome substrates. Thus, Rep8 tethers p......The protein known as p97 or VCP in mammals and Cdc48 in yeast is a versatile ATPase complex involved in several biological functions including membrane fusion, protein folding, and activation of membrane-bound transcription factors. In addition, p97 plays a central role in degradation of misfolded...... protein named Rep8 or Ubxd6 as a new cofactor of p97. Mouse Rep8 is highly tissue-specific and abundant in gonads. In testes, Rep8 is expressed in post-meiotic round spermatids, whereas in ovaries Rep8 is expressed in granulosa cells. Rep8 associates directly with p97 via its UBX domain. We show that Rep8...

El concepto de República en José Martí

OpenAIRE

Dr. Ibrahim Hidalgo

2015-01-01

El acercamiento a una visión martiana sobre el concepto de la república es la esencia del artículo, donde se parte del análisis de sus textos, situando el concepto de república en el centro de su pensamiento y su actuar políticos e ideológicos, que han devenido objeto de análisis y valoraciones desde diversos ángulos, perspectivas y proyecciones por autores que a lo largo del siglo XX, y en la actualidad. El elemento esencial de la concepción es el ser individualmente considerado, cuya unión ...

Obliquamente, os mitos. (República, II

Directory of Open Access Journals (Sweden)

Loraine Oliveira

2016-12-01

Full Text Available A República é um texto repleto de mitos, que ora são condenados, ora integrados à educação na cidade. No livro II a discussão mostra quais são condenáveis e quais são úteis. E o motivo dessa posição ambivalente de Platão a respeito do mito é um só: os mitos se imprimem na alma. Sendo assim, eles são formadores do caráter. O problema é que há mitos pseûdos, ou seja, falsos, mentirosos, fictícios. E há mitos que possuem um elemento de verdade e um elemento pseûdos. Mas eles jamais são completamente verdadeiros. Ora, qual a função do pseûdos, considerando que os mitos formam o caráter? Um discurso, seja ficcional, ou mítico, pode ser filosófico? Se isso for possível, o texto da República não é ele mesmo uma ficção? Um mito? Por breves apontamentos, este estudo segue essas questões.

Lipofection of purified adeno-associated virus Rep68 protein: toward a chromosome-targeting nonviral particle.

Science.gov (United States)

Lamartina, S; Roscilli, G; Rinaudo, D; Delmastro, P; Toniatti, C

1998-09-01

Adeno-associated virus (AAV) integrates very efficiently into a specific site (AAVS1) of human chromosome 19. Two elements of the AAV genome are sufficient: the inverted terminal repeats (ITRs) and the Rep78 or Rep68 protein. The incorporation of the AAV integration machinery in nonviral delivery systems is of great interest for gene therapy. We demonstrate that purified recombinant Rep68 protein is functionally active when directly delivered into human cells by using the polycationic liposome Lipofectamine, promoting the rescue-replication of a codelivered ITR-flanked cassette in adenovirus-infected cells and its site-specific integration in noninfected cells. The sequencing of cloned virus-host DNA junctions confirmed that lipofected Rep68 protein triggers site-specific integration at the same sites in chromosome 19 already characterized in cells latently infected with AAV.

Hariduspoliitikas ilmnevad üksmeele märgid / Mailis Reps

Index Scriptorium Estoniae

Reps, Mailis, 1975-

2006-01-01

Ilmunud ka: Severnoje Poberezhje 7. juuni lk. 2, Nädaline 10. juuni lk. 2. Haridusminister Mailis Reps Res Publica ja Isamaaliidu ühisest haridusprogrammist ning juba teostumas hariduspoliitilistest eesmärkidest

The adeno-associated virus major regulatory protein Rep78-c-Jun-DNA motif complex modulates AP-1 activity

International Nuclear Information System (INIS)

Prasad, C. Krishna; Meyers, Craig; Zhan Dejin; You Hong; Chiriva-Internati, Maurizio; Mehta, Jawahar L.; Liu Yong; Hermonat, Paul L.

2003-01-01

Multiple epidemiologic studies show that adeno-associated virus (AAV) is negatively associated with cervical cancer (CX CA), a cancer which is positively associated with human papillomavirus (HPV) infection. Mechanisms for this correlation may be by Rep78's (AAV's major regulatory protein) ability to bind the HPV-16 p97 promoter DNA and inhibit transcription, to bind and interfere with the functions of the E7 oncoprotein of HPV-16, and to bind a variety of HPV-important cellular transcription factors such as Sp1 and TBP. c-Jun is another important cellular factor intimately linked to the HPV life cycle, as well as keratinocyte differentiation and skin development. Skin is the natural host tissue for both HPV and AAV. In this article it is demonstrated that Rep78 directly interacts with c-Jun, both in vitro and in vivo, as analyzed by Western blot, yeast two-hybrid cDNA, and electrophoretic mobility shift-supershift assay (EMSA supershift). Addition of anti-Rep78 antibodies inhibited the EMSA supershift. Investigating the biological implications of this interaction, Rep78 inhibited the c-Jun-dependent c-jun promoter in transient and stable chloramphenicol acetyl-transferase (CAT) assays. Rep78 also inhibited c-Jun-augmented c-jun promoter as well as the HPV-16 p97 promoter activity (also c-Jun regulated) in in vitro transcription assays in T47D nuclear extracts. Finally, the Rep78-c-Jun interaction mapped to the amino-half of Rep78. The ability of Rep78 to interact with c-Jun and down-regulate AP-1-dependent transcription suggests one more mechanism by which AAV may modulate the HPV life cycle and the carcinogenesis process

RepSox improves viability and regulates gene expression in rhesus monkey-pig interspecies cloned embryos.

Science.gov (United States)

Zhu, Hai-Ying; Jin, Long; Guo, Qing; Luo, Zhao-Bo; Li, Xiao-Chen; Zhang, Yu-Chen; Xing, Xiao-Xu; Xuan, Mei-Fu; Zhang, Guang-Lei; Luo, Qi-Rong; Wang, Jun-Xia; Cui, Cheng-Du; Li, Wen-Xue; Cui, Zheng-Yun; Yin, Xi-Jun; Kang, Jin-Dan

2017-05-01

To investigate the effect of the small molecule, RepSox, on the expression of developmentally important genes and the pre-implantation development of rhesus monkey-pig interspecies somatic cell nuclear transfer (iSCNT) embryos. Rhesus monkey cells expressing the monomeric red fluorescent protein 1 which have a normal (42) chromosome complement, were used as donor cells to generate iSCNT embryos. RepSox increased the expression levels of the pluripotency-related genes, Oct4 and Nanog (p  0.05), this was not significant. RepSox can improve the developmental potential of rhesus monkey-pig iSCNT embryos by regulating the expression of pluripotency-related genes.

The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins.

Directory of Open Access Journals (Sweden)

Louise Madsen

Full Text Available The protein known as p97 or VCP in mammals and Cdc48 in yeast is a versatile ATPase complex involved in several biological functions including membrane fusion, protein folding, and activation of membrane-bound transcription factors. In addition, p97 plays a central role in degradation of misfolded secretory proteins via the ER-associated degradation pathway. This functional diversity of p97 depends on its association with various cofactors, and to further our understanding of p97 function it is important that these cofactors are identified and analyzed. Here, we isolate and characterize the human protein named Rep8 or Ubxd6 as a new cofactor of p97. Mouse Rep8 is highly tissue-specific and abundant in gonads. In testes, Rep8 is expressed in post-meiotic round spermatids, whereas in ovaries Rep8 is expressed in granulosa cells. Rep8 associates directly with p97 via its UBX domain. We show that Rep8 is a transmembrane protein that localizes to the ER membrane with its UBX domain facing the cytoplasm. Knock-down of Rep8 expression in human cells leads to a decreased association of p97 with the ER membrane and concomitantly a retarded degradation of misfolded ER-derived proteasome substrates. Thus, Rep8 tethers p97 to the ER membrane for efficient ER-associated degradation.

Tight regulation of the intS gene of the KplE1 prophage: a new paradigm for integrase gene regulation.

Directory of Open Access Journals (Sweden)

Gaël Panis

2010-10-01

Full Text Available Temperate phages have the ability to maintain their genome in their host, a process called lysogeny. For most, passive replication of the phage genome relies on integration into the host's chromosome and becoming a prophage. Prophages remain silent in the absence of stress and replicate passively within their host genome. However, when stressful conditions occur, a prophage excises itself and resumes the viral cycle. Integration and excision of phage genomes are mediated by regulated site-specific recombination catalyzed by tyrosine and serine recombinases. In the KplE1 prophage, site-specific recombination is mediated by the IntS integrase and the TorI recombination directionality factor (RDF. We previously described a sub-family of temperate phages that is characterized by an unusual organization of the recombination module. Consequently, the attL recombination region overlaps with the integrase promoter, and the integrase and RDF genes do not share a common activated promoter upon lytic induction as in the lambda prophage. In this study, we show that the intS gene is tightly regulated by its own product as well as by the TorI RDF protein. In silico analysis revealed that overlap of the attL region with the integrase promoter is widely encountered in prophages present in prokaryotic genomes, suggesting a general occurrence of negatively autoregulated integrase genes. The prediction that these integrase genes are negatively autoregulated was biologically assessed by studying the regulation of several integrase genes from two different Escherichia coli strains. Our results suggest that the majority of tRNA-associated integrase genes in prokaryotic genomes could be autoregulated and that this might be correlated with the recombination efficiency as in KplE1. The consequences of this unprecedented regulation for excessive recombination are discussed.

First EURONEAR NEA discoveries from La Palma using the INT

Science.gov (United States)

Vaduvescu, O.; Hudin, L.; Tudor, V.; Char, F.; Mocnik, T.; Kwiatkowski, T.; de Leon, J.; Cabrera-Lavers, A.; Alvarez, C.; Popescu, M.; Cornea, R.; Díaz Alfaro, M.; Ordonez-Etxeberria, I.; Kamiński, K.; Stecklum, B.; Verdes-Montenegro, L.; Sota, A.; Casanova, V.; Martin Ruiz, S.; Duffard, R.; Zamora, O.; Gomez-Jimenez, M.; Micheli, M.; Koschny, D.; Busch, M.; Knofel, A.; Schwab, E.; Negueruela, I.; Dhillon, V.; Sahman, D.; Marchant, J.; Génova-Santos, R.; Rubiño-Martín, J. A.; Riddick, F. C.; Mendez, J.; Lopez-Martinez, F.; Gänsicke, B. T.; Hollands, M.; Kong, A. K. H.; Jin, R.; Hidalgo, S.; Murabito, S.; Font, J.; Bereciartua, A.; Abe, L.; Bendjoya, P.; Rivet, J. P.; Vernet, D.; Mihalea, S.; Inceu, V.; Gajdos, S.; Veres, P.; Serra-Ricart, M.; Abreu Rodriguez, D.

2015-05-01

Since 2006, the European Near Earth Asteroids Research (EURONEAR) project has been contributing to the research of near-Earth asteroids (NEAs) within a European network. One of the main aims is the amelioration of the orbits of NEAs, and starting in 2014 February we focus on the recovery of one-opposition NEAs using the Isaac Newton Telescope (INT) in La Palma in override mode. Part of this NEA recovery project, since 2014 June EURONEAR serendipitously started to discover and secure the first NEAs from La Palma and using the INT, thanks to the teamwork including amateurs and students who promptly reduce the data, report discoveries and secure new objects recovered with the INT and few other telescopes from the EURONEAR network. Five NEAs were discovered with the INT, including 2014 LU14, 2014 NL52 (one very fast rotator), 2014 OL339 (the fourth known Earth quasi-satellite), 2014 SG143 (a quite large NEA), and 2014 VP. Another very fast moving NEA was discovered but was unfortunately lost due to lack of follow-up time. Additionally, another 14 NEA candidates were identified based on two models, all being rapidly followed-up using the INT and another 11 telescopes within the EURONEAR network. They include one object discovered by Pan-STARRS, two Mars crossers, two Hungarias, one Jupiter trojan, and other few inner main belt asteroids (MBAs). Using the INT and Sierra Nevada 1.5 m for photometry, then the Gran Telescopio de Canarias for spectroscopy, we derived the very rapid rotation of 2014 NL52, then its albedo, magnitude, size, and its spectral class. Based on the total sky coverage in dark conditions, we evaluate the actual survey discovery rate using 2-m class telescopes. One NEA is possible to be discovered randomly within minimum 2.8 deg2 and maximum 5.5 deg2. These findings update our past statistics, being based on double sky coverage and taking into account the recent increase in discovery.

Initial characterization of the Pf-Int recombinase from the malaria parasite Plasmodium falciparum.

Directory of Open Access Journals (Sweden)

Mehdi Ghorbal

Full Text Available Genetic variation is an essential means of evolution and adaptation in many organisms in response to environmental change. Certain DNA alterations can be carried out by site-specific recombinases (SSRs that fall into two families: the serine and the tyrosine recombinases. SSRs are seldom found in eukaryotes. A gene homologous to a tyrosine site-specific recombinase has been identified in the genome of Plasmodium falciparum. The sequence is highly conserved among five other members of Plasmodia.The predicted open reading frame encodes for a ∼57 kDa protein containing a C-terminal domain including the putative tyrosine recombinase conserved active site residues R-H-R-(H/W-Y. The N-terminus has the typical alpha-helical bundle and potentially a mixed alpha-beta domain resembling that of λ-Int. Pf-Int mRNA is expressed differentially during the P. falciparum erythrocytic life stages, peaking in the schizont stage. Recombinant Pf-Int and affinity chromatography of DNA from genomic or synthetic origin were used to identify potential DNA targets after sequencing or micro-array hybridization. Interestingly, the sequences captured also included highly variable subtelomeric genes such as var, rif, and stevor sequences. Electrophoretic mobility shift assays with DNA were carried out to verify Pf-Int/DNA binding. Finally, Pf-Int knock-out parasites were created in order to investigate the biological role of Pf-Int.Our data identify for the first time a malaria parasite gene with structural and functional features of recombinases. Pf-Int may bind to and alter DNA, either in a sequence specific or in a non-specific fashion, and may contribute to programmed or random DNA rearrangements. Pf-Int is the first molecular player identified with a potential role in genome plasticity in this pathogen. Finally, Pf-Int knock-out parasite is viable showing no detectable impact on blood stage development, which is compatible with such function.

Interlaboratory reproducibility of DiversiLab rep-PCR typing and clustering of Acinetobacter baumannii isolates.

Science.gov (United States)

Higgins, Paul G; Hujer, Andrea M; Hujer, Kristine M; Bonomo, Robert A; Seifert, Harald

2012-01-01

We have investigated the reproducibility of DiversiLab rep-PCR fingerprints between two laboratories with the aim of determining if the fingerprints and clustering are laboratory-specific or portable. One-hundred non-duplicate Acinetobacter baumannii isolates were used in this study. DNA isolation and rep-PCR were each performed separately in two laboratories and rep-PCR patterns generated in laboratory A were compared with those from laboratory B. Twelve A. baumannii isolates processed in laboratory A showed ≥98 % pattern similarity with the corresponding 12 isolates tested in laboratory B and were considered identical. Sixty-four isolates showed 95-97.9 % similarity with their corresponding isolates. Twenty-three isolates showed 90-94 % similarity with the corresponding isolates, while one isolate showed only 87.4 % similarity. However, intra-laboratory clustering was conserved: isolates that clustered in laboratory A also clustered in laboratory B. While clustering was conserved and reproducible at two different laboratories, demonstrating the robustness of rep-PCR, interlaboratory comparison of individual isolate fingerprints showed more variability. This comparison allows conclusions regarding clonality to be reached independent of the laboratory where the analysis is performed.

El concepto de República en José Martí

Directory of Open Access Journals (Sweden)

Dr. Ibrahim Hidalgo

2015-10-01

Full Text Available El acercamiento a una visión martiana sobre el concepto de la república es la esencia del artículo, donde se parte del análisis de sus textos, situando el concepto de república en el centro de su pensamiento y su actuar políticos e ideológicos, que han devenido objeto de análisis y valoraciones desde diversos ángulos, perspectivas y proyecciones por autores que a lo largo del siglo XX, y en la actualidad. El elemento esencial de la concepción es el ser individualmente considerado, cuya unión constituye el pueblo, que deviene así no un ente abstracto y amorfo, sino un conglomerado de personas

Applications of the rep-PCR DNA fingerprinting technique to study microbial diversity, ecology and evolution.

Science.gov (United States)

Ishii, Satoshi; Sadowsky, Michael J

2009-04-01

A large number of repetitive DNA sequences are found in multiple sites in the genomes of numerous bacteria, archaea and eukarya. While the functions of many of these repetitive sequence elements are unknown, they have proven to be useful as the basis of several powerful tools for use in molecular diagnostics, medical microbiology, epidemiological analyses and environmental microbiology. The repetitive sequence-based PCR or rep-PCR DNA fingerprint technique uses primers targeting several of these repetitive elements and PCR to generate unique DNA profiles or 'fingerprints' of individual microbial strains. Although this technique has been extensively used to examine diversity among variety of prokaryotic microorganisms, rep-PCR DNA fingerprinting can also be applied to microbial ecology and microbial evolution studies since it has the power to distinguish microbes at the strain or isolate level. Recent advancement in rep-PCR methodology has resulted in increased accuracy, reproducibility and throughput. In this minireview, we summarize recent improvements in rep-PCR DNA fingerprinting methodology, and discuss its applications to address fundamentally important questions in microbial ecology and evolution.

Safety and efficacy of REP 2139 and pegylated interferon alfa-2a for treatment-naive patients with chronic hepatitis B virus and hepatitis D virus co-infection (REP 301 and REP 301-LTF): a non-randomised, open-label, phase 2 trial.

Science.gov (United States)

Bazinet, Michel; Pântea, Victor; Cebotarescu, Valentin; Cojuhari, Lilia; Jimbei, Pavlina; Albrecht, Jeffrey; Schmid, Peter; Le Gal, Frédéric; Gordien, Emmanuel; Krawczyk, Adalbert; Mijočević, Hrvoje; Karimzadeh, Hadi; Roggendorf, Michael; Vaillant, Andrew

2017-12-01

REP 2139 clears circulating hepatitis B virus (HBV) surface antigen (HBsAg), enhancing the restoration of functional control of HBV infection by immunotherapy. We assessed the safety and efficacy of REP 2139 and pegylated interferon alfa-2a in patients with chronic HBV and hepatitis D virus (HDV) co-infection. In this open-label, non-randomised, phase 2 trial, patients aged 18-55 years, who were treatment naive, hepatitis B e antigen [HBeAg] negative, anti-hepatitis D antigen [HDAg] positive, and HDV RNA positive, with serum HBsAg concentrations of more than 1000 IU/mL, and a history of HDV infection for 6 months or more before treatment, were recruited at Toma Ciorbă Hospital of Infectious Diseases in Chișinău, Moldova. Patients were excluded if they had HDV superinfection, liver infections other than HBV and HDV, or liver cirrhosis. Patients received 500 mg intravenous REP 2139 once per week for 15 weeks, followed by combined therapy with 250 mg intravenous REP 2139 and 180 μg subcutaneous pegylated interferon alfa-2a once per week for 15 weeks, then monotherapy with 180 μg pegylated interferon alfa-2a once per week for 33 weeks. The primary endpoints assessed at the end of treatment were the safety and tolerability of the treatment regimen, analysed in the intention-to-treat population. Secondary outcomes included the proportion of patients with serum HBsAg less than 50 IU/mL, the proportion of patients with suppressed HBV DNA, and the proportion of patients who maintained these responses through follow-up. The REP 301 trial is registered with ClinicalTrials.gov, number NCT02233075. We also did an additional follow-up at 1 year after the end of treatment, as an interim analysis of the REP 301-LTF trial (planned duration 3 years), registered with ClinicalTrials.gov, number NCT02876419, which is ongoing but not recruiting patients. Between Sept 8, 2014, and Jan 27, 2015, we enrolled 12 patients into the REP 301 study. All 12 patients experienced at least one

The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases

Science.gov (United States)

Orchard, Sandra; Ammari, Mais; Aranda, Bruno; Breuza, Lionel; Briganti, Leonardo; Broackes-Carter, Fiona; Campbell, Nancy H.; Chavali, Gayatri; Chen, Carol; del-Toro, Noemi; Duesbury, Margaret; Dumousseau, Marine; Galeota, Eugenia; Hinz, Ursula; Iannuccelli, Marta; Jagannathan, Sruthi; Jimenez, Rafael; Khadake, Jyoti; Lagreid, Astrid; Licata, Luana; Lovering, Ruth C.; Meldal, Birgit; Melidoni, Anna N.; Milagros, Mila; Peluso, Daniele; Perfetto, Livia; Porras, Pablo; Raghunath, Arathi; Ricard-Blum, Sylvie; Roechert, Bernd; Stutz, Andre; Tognolli, Michael; van Roey, Kim; Cesareni, Gianni; Hermjakob, Henning

2014-01-01

IntAct (freely available at http://www.ebi.ac.uk/intact) is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. IntAct has developed a sophisticated web-based curation tool, capable of supporting both IMEx- and MIMIx-level curation. This tool is now utilized by multiple additional curation teams, all of whom annotate data directly into the IntAct database. Members of the IntAct team supply appropriate levels of training, perform quality control on entries and take responsibility for long-term data maintenance. Recently, the MINT and IntAct databases decided to merge their separate efforts to make optimal use of limited developer resources and maximize the curation output. All data manually curated by the MINT curators have been moved into the IntAct database at EMBL-EBI and are merged with the existing IntAct dataset. Both IntAct and MINT are active contributors to the IMEx consortium (http://www.imexconsortium.org). PMID:24234451

A Comparison of Molecular Typing Methods Applied to Enterobacter cloacae complex: hsp60 Sequencing, Rep-PCR, and MLST

Directory of Open Access Journals (Sweden)

Roberto Viau

2017-02-01

Full Text Available Molecular typing using repetitive sequenced-based PCR (rep-PCR and hsp60 sequencing were applied to a collection of diverse Enterobacter cloacae complex isolates. To determine the most practical method for reference laboratories, we analyzed 71 E. cloacae complex isolates from sporadic and outbreak occurrences originating from 4 geographic areas. While rep-PCR was more discriminating, hsp60 sequencing provided a broader and a more objective geographical tracking method similar to multilocus sequence typing (MLST. In addition, we suggest that MLST may have higher discriminative power compared to hsp60 sequencing, although rep-PCR remains the most discriminative method for local outbreak investigations. In addition, rep-PCR can be an effective and inexpensive method for local outbreak investigation.

L'intégrité au CERN

CERN Document Server

HR, Department

2015-01-01

Pour mener à bien sa mission, le CERN compte sur la confiance et le soutien matériel de ses États membres et de ses partenaires, et se doit de gérer de manière exemplaire les ressources qui lui sont confiées. Dès lors, le CERN attend la plus haute intégrité de la part de tous ses collaborateurs (membres du personnel, consultants, contractants travaillant sur le domaine ou personne engagée à tout autre titre au CERN ou pour le compte de celui-ci). L’intégrité est l’une des valeurs essentielles du CERN. Elle est définie dans le Code de conduite comme le fait d’« agir avec éthique, en toute honnêteté intellectuelle et en étant responsable de ses actes ».

Process modeling for the Integrated Nonthermal Treatment System (INTS) study

Energy Technology Data Exchange (ETDEWEB)

Brown, B.W.

1997-04-01

This report describes the process modeling done in support of the Integrated Nonthermal Treatment System (INTS) study. This study was performed to supplement the Integrated Thermal Treatment System (ITTS) study and comprises five conceptual treatment systems that treat DOE contract-handled mixed low-level wastes (MLLW) at temperatures of less than 350{degrees}F. ASPEN PLUS, a chemical process simulator, was used to model the systems. Nonthermal treatment systems were developed as part of the INTS study and include sufficient processing steps to treat the entire inventory of MLLW. The final result of the modeling is a process flowsheet with a detailed mass and energy balance. In contrast to the ITTS study, which modeled only the main treatment system, the INTS study modeled each of the various processing steps with ASPEN PLUS, release 9.1-1. Trace constituents, such as radionuclides and minor pollutant species, were not included in the calculations.

Identification of Tilletia species using rep-PCR fingerprinting technique

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Župunski Vesna

2011-01-01

Full Text Available Analyzing 167 non-processed seed samples of wheat, it was found that 145 samples (86.8 % were contaminated with Tilletia species, while 22 (13.2 % samples were not contaminated. By using rep-PCR fingerprinting technique, it was found that DNA isolates of T. tritici originated from Serbian wheat samples had 80 % similarity with positive control for T. tritici. One isolate shared similarity of 60% with T. tritici, T. controversa and T. laevis. It was supposed that this isolate belongs to T. bromi. Isolate of T. laevis shared a similarity of 70 % with isolates of T. tritici and T. controversa, while T. walkeri was more than 10 % similar with T. tritici, T. controversa and T. laevis. Although T. controversa and T. tritici had high percent of genetic similarity, they were clustered separately. Our results suggest that rep-PCR fingerprinting could be a useful tool for monitoring presence of morphologically similar Tilletia species in wheat production areas.

Genetic Diversity and Evidence for Transmission of Streptococcus mutans by DiversiLab rep-PCR.

Science.gov (United States)

Momeni, Stephanie S; Whiddon, Jennifer; Cheon, Kyounga; Ghazal, Tariq; Moser, Stephen A; Childers, Noel K

2016-09-01

This two-part study investigated the genetic diversity and transmission of Streptococcus mutans using the DiversiLab repetitive extragenic palindromic PCR (rep-PCR) approach. For children with S. mutans and participating household members, analysis for evidence of unrelated child-to-child as well as intra-familial transmission was evaluated based on commonality of genotypes. A total of 169 index children and 425 household family members from Uniontown, Alabama were evaluated for genetic diversity using rep-PCR. Thirty-four unique rep-PCR genotypes were observed for 13,906 S. mutans isolates. For transmission, 117 child and household isolates were evaluated for shared genotype (by child and by genotype cases, multiple matches possible for each child). Overall, children had 1-9 genotypes and those with multiple genotypes were 2.3 times more likely to have caries experience (decayed, missing and filled teeth/surfaces>0). Only 28% of children shared all genotypes within the household, while 72% had at least 1 genotype not shared with anyone in the household. Children had genotype(s) not shared with any household members in 157 cases. In 158 cases children and household members shared a genotype in which 55% (87/158 cases) were shared with more than one family member. Children most frequently shared genotypes with their mothers (54%; 85/158), siblings (46%; 72/158) and cousins (23%; 37/158). A reference library for S. mutans for epidemiological surveillance using the DiversiLab rep-PCR approach is detailed. The genetic diversity of S. mutans in this population demonstrated frequent commonality of genotypes. Evidence for both child-to-child and intra-familial transmission of S. mutans was observed by rep-PCR. Copyright © 2016 Elsevier B.V. All rights reserved.

Yeast identification by sequencing, biochemical kits, MALDI-TOF MS and rep-PCR DNA fingerprinting.

Science.gov (United States)

Zhao, Ying; Tsang, Chi-Ching; Xiao, Meng; Chan, Jasper F W; Lau, Susanna K P; Kong, Fanrong; Xu, Yingchun; Woo, Patrick C Y

2017-12-08

No study has comprehensively evaluated the performance of 28S nrDNA and ITS sequencing, commercial biochemical test kits, MALDI-TOF MS platforms, and the emerging rep-PCR DNA fingerprinting technology using a cohort of yeast strains collected from a clinical microbiology laboratory. In this study, using 71 clinically important yeast isolates (excluding Candida albicans) collected from a single centre, we determined the concordance of 28S nrDNA and ITS sequencing and evaluated the performance of two commercial test kits, two MALDI-TOF MS platforms, and rep-PCR DNA fingerprinting. 28S nrDNA and ITS sequencing showed complete agreement on the identities of the 71 isolates. Using sequencing results as the standard, 78.9% and 71.8% isolates were correctly identified using the API 20C AUX and Vitek 2 YST ID Card systems, respectively; and 90.1% and 80.3% isolates were correctly identified using the Bruker and Vitek MALDI-TOF MS platforms, respectively. Of the 18 strains belonging to the Candida parapsilosis species complex tested by DiversiLab automated rep-PCR DNA fingerprinting, all were identified only as Candida parapsilosis with similarities ≥93.2%, indicating the misidentification of Candida metapsilosis and Candida orthopsilosis. However, hierarchical cluster analysis of the rep-PCR DNA fingerprints of these three species within this species complex formed three different discrete clusters, indicating that this technology can potentially differentiate the three species. To achieve higher accuracies of identification, the databases of commercial biochemical test kits, MALDI-TOF MS platforms, and DiversiLab automated rep-PCR DNA fingerprinting needs further enrichment, particularly for uncommonly encountered yeast species. © The Author 2017. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Open-Source Wax RepRap 3-D Printer for Rapid Prototyping Paper-Based Microfluidics.

Science.gov (United States)

Pearce, J M; Anzalone, N C; Heldt, C L

2016-08-01

The open-source release of self-replicating rapid prototypers (RepRaps) has created a rich opportunity for low-cost distributed digital fabrication of complex 3-D objects such as scientific equipment. For example, 3-D printable reactionware devices offer the opportunity to combine open hardware microfluidic handling with lab-on-a-chip reactionware to radically reduce costs and increase the number and complexity of microfluidic applications. To further drive down the cost while improving the performance of lab-on-a-chip paper-based microfluidic prototyping, this study reports on the development of a RepRap upgrade capable of converting a Prusa Mendel RepRap into a wax 3-D printer for paper-based microfluidic applications. An open-source hardware approach is used to demonstrate a 3-D printable upgrade for the 3-D printer, which combines a heated syringe pump with the RepRap/Arduino 3-D control. The bill of materials, designs, basic assembly, and use instructions are provided, along with a completely free and open-source software tool chain. The open-source hardware device described here accelerates the potential of the nascent field of electrochemical detection combined with paper-based microfluidics by dropping the marginal cost of prototyping to nearly zero while accelerating the turnover between paper-based microfluidic designs. © 2016 Society for Laboratory Automation and Screening.

La república conservadora

Directory of Open Access Journals (Sweden)

Matías Muraca

2011-12-01

Full Text Available Este artigo tem como objetivo revisar e analisar como aparece a discussão sobre República ao longo dos anos de redemocratização na Argentina, articulando com outra categoria da teoria política: o populismo. Os conteúdos e sentidos da demanda republicana que se conjuga com populismo são analisados nas edições de um dos mais importantes jornais argentinos durante o segundo governo de Carlos Saúl Menem (1995-1999 e o governo de Aliança (1999-2001. Especificamente, é revisado nas Colunas de Opinião do Diário “La Nación” a primeira etapa das críticas republicanas centradas em um dos seus componentes principais: a questão da corrupção associada a problemática da moral.

IntPath--an integrated pathway gene relationship database for model organisms and important pathogens.

Science.gov (United States)

Zhou, Hufeng; Jin, Jingjing; Zhang, Haojun; Yi, Bo; Wozniak, Michal; Wong, Limsoon

2012-01-01

Pathway data are important for understanding the relationship between genes, proteins and many other molecules in living organisms. Pathway gene relationships are crucial information for guidance, prediction, reference and assessment in biochemistry, computational biology, and medicine. Many well-established databases--e.g., KEGG, WikiPathways, and BioCyc--are dedicated to collecting pathway data for public access. However, the effectiveness of these databases is hindered by issues such as incompatible data formats, inconsistent molecular representations, inconsistent molecular relationship representations, inconsistent referrals to pathway names, and incomprehensive data from different databases. In this paper, we overcome these issues through extraction, normalization and integration of pathway data from several major public databases (KEGG, WikiPathways, BioCyc, etc). We build a database that not only hosts our integrated pathway gene relationship data for public access but also maintains the necessary updates in the long run. This public repository is named IntPath (Integrated Pathway gene relationship database for model organisms and important pathogens). Four organisms--S. cerevisiae, M. tuberculosis H37Rv, H. Sapiens and M. musculus--are included in this version (V2.0) of IntPath. IntPath uses the "full unification" approach to ensure no deletion and no introduced noise in this process. Therefore, IntPath contains much richer pathway-gene and pathway-gene pair relationships and much larger number of non-redundant genes and gene pairs than any of the single-source databases. The gene relationships of each gene (measured by average node degree) per pathway are significantly richer. The gene relationships in each pathway (measured by average number of gene pairs per pathway) are also considerably richer in the integrated pathways. Moderate manual curation are involved to get rid of errors and noises from source data (e.g., the gene ID errors in WikiPathways and

The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases

OpenAIRE

Orchard, S; Ammari, M; Aranda, B; Breuza, L; Briganti, L; Broackes-Carter, F; Campbell, N; Chavali, G; Chen, C; del-Toro, N; Duesbury, M; Dumousseau, M; Galeota, E; Hinz, U; Iannuccelli, M

2014-01-01

IntAct (freely available at http://www.ebi.ac.uk/intact) is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. IntAct has developed a sophisticated web-based curation tool, capable of supporting both IMEx- and MIMIx-level curation. This tool is now utilized by multiple additional curation teams, all of whom annotate data directly into the IntAct database. Members of the IntAct team supply appropriate l...

Repères bibliographiques ...

OpenAIRE

2018-01-01

L’histoire de la République fédérale d’Allemagne, ses institutions, son système social et économique, sa politique intérieure et extérieure ont déjà été beaucoup étudiés et font l’objet de publications nombreuses dont la liste s’allonge constamment. Pour compléter les indications fournies ci‑dessus par les auteurs des diverses contributions, nous nous contenterons ici de signaler quelques titres et de donner quelques conseils permettant au lecteur de trou­ver rapidement la documentation et l’...

Short Term INT-Formazan Production as a Proxy for Marine Prokaryote Respiration

Science.gov (United States)

Cajal-Medrano, R.; Villegas-Mendoza, J.; Maske, H.

2016-02-01

Prokaryotes are poisoned by the tetrazolium electron transport probe INT on time scales of less than one hour, invalidating the interpretation of the rate of in vivo INT reduction to formazan as a proxy for oxygen consumption rates (Villegas-Mendoza et al. 2015). We measured oxygen consumption rate (R; µM O2 hour-1) and electron transport activity with in vivo INT formazan production (IFP, mM formazan) at 0.5 mM INT during 1 hour exposure time of natural communities and cultures of the marine bacteria Vibrio harveyi growing in batch and continuous cultures. A strong exponential relationship R = 0.20 IFP2.15 (pgrowth rates under aerobic condition. We find that IFP and oxygen consumption increase with bacterial specific growth rates and temperature as expected from basic principles of physiology and biochemistry. Oxygen and nitrogen saturated batch cultures of V. harveyi showed that both, IFP and oxygen consumption increased for 0.8 hours but then stopped similar to natural bacterial communities supporting the above relationship of IFP to prokaryote respiration. Our method implies adding 0.5 mM INT to a plankton sample and incubating for less than 1 hour. After prokaryote separation by size filtration (0.8 mm), the formazan crystals are collected by filtration (0.2 mm) and dissolved in propanol. The absorbance at 485 nm per sample volume yields the formazan potential that is related to prokaryote respiration in the sample.

A república e o sonho The republic and its dream

Directory of Open Access Journals (Sweden)

Maria Tereza Chaves de Mello

2011-06-01

Full Text Available O desencanto com a República brasileira tem sido tema de reflexões desde os seus momentos iniciais. Buscando os conteúdos concretos dos sonhos republicanos na década de 1880 e na Primeira República vamos achar uma importante defasagem entre eles não exatamente em função do marco cronológico, mas do grupo social que, respectivamente, os acalentou.The disillusion with the Brazilian Republic since its first days has been a topic of academician reflexions. Examinating the concrete contents of the 1880`s and the First Republic republican dreams we will find a substantive difference between them. To be exact, this difference must not be related to the chronological demarcation but to the social group that embraced each of them.

Études d'intégration pour l'accélérateur LHC

CERN Document Server

Muttoni, Y

2004-01-01

Dans tous les projets de recherche ou industriels, l'intégration est une phase préalable et indispensable à l'installation de services ou d'équipements. Dans une première partie, il est montré comment et suivant quelle méthode ont été conduites les études d'intégration de la machine LHC. Puis dans une deuxième partie, sera présenté le site WEB de l'ICL (Intégration Cellule LHC), l'outil de diffusion des informations générées par les études d'intégration. Enfin, la gestion des documents de non-conformités d'installation, via le système MTF sera décrite.

Production of recombinant AAV vectors encoding insulin-like growth factor I is enhanced by interaction among AAV rep regulatory sequences

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Dilley Robert

2009-01-01

Full Text Available Abstract Background Adeno-associated virus (AAV vectors are promising tools for gene therapy. Currently, their potential is limited by difficulties in producing high vector yields with which to generate transgene protein product. AAV vector production depends in part upon the replication (Rep proteins required for viral replication. We tested the hypothesis that mutations in the start codon and upstream regulatory elements of Rep78/68 in AAV helper plasmids can regulate recombinant AAV (rAAV vector production. We further tested whether the resulting rAAV vector preparation augments the production of the potentially therapeutic transgene, insulin-like growth factor I (IGF-I. Results We constructed a series of AAV helper plasmids containing different Rep78/68 start codon in combination with different gene regulatory sequences. rAAV vectors carrying the human IGF-I gene were prepared with these vectors and the vector preparations used to transduce HT1080 target cells. We found that the substitution of ATG by ACG in the Rep78/68 start codon in an AAV helper plasmid (pAAV-RC eliminated Rep78/68 translation, rAAV and IGF-I production. Replacement of the heterologous sequence upstream of Rep78/68 in pAAV-RC with the AAV2 endogenous p5 promoter restored translational activity to the ACG mutant, and restored rAAV and IGF-I production. Insertion of the AAV2 p19 promoter sequence into pAAV-RC in front of the heterologous sequence also enabled ACG to function as a start codon for Rep78/68 translation. The data further indicate that the function of the AAV helper construct (pAAV-RC, that is in current widespread use for rAAV production, may be improved by replacement of its AAV2 unrelated heterologous sequence with the native AAV2 p5 promoter. Conclusion Taken together, the data demonstrate an interplay between the start codon and upstream regulatory sequences in the regulation of Rep78/68 and indicate that selective mutations in Rep78/68 regulatory elements

High-rep-rate Thomson scattering for LHD

Science.gov (United States)

den Hartog, D. J.; Borchardt, M. T.; Holly, D. J.; Schmitz, O.; Yasuhara, R.; Yamada, I.; Funaba, H.; Osakabe, M.; Morisaki, T.

2017-10-01

A high-rep-rate pulse-burst laser system is being built for the LHD Thomson scattering (TS) diagnostic. This laser will have two operating scenarios, a fast-burst sequence of 15 kHz rep rate for at least 15 ms, and a slow-burst sequence of 1 kHz for at least 50 ms. There will be substantial flexibility in burst sequences for tailoring to experimental requirements. This new laser system will operate alongside the existing lasers in the LHD TS diagnostic, and will use the same beamline. This increase in temporal resolution capability complements the high spatial resolution (144 points) of the LHD TS diagnostic, providing unique measurement capability unmatched on any other fusion experiment. The new pulse-burst laser is a straightforward application of technology developed at UW-Madison, consisting of a Nd:YAG laser head with modular flashlamp drive units and a customized control system. Variable pulse-width drive of the flashlamps is accomplished by IGBT (insulated gate bipolar transistor) switching of electrolytic capacitor banks. Direct control of the laser Pockels cell drive enables optimal pulse energy extraction, producing >1.5 J q-switched pulses with 20 ns FWHM. Burst operation of this laser system will be used to capture fast time evolution of the electron temperature and density profiles during events such as ELMs, RMP perturbations, and various MHD modes. This work is supported by the U. S. Department of Energy and the National Institute for Fusion Science (Japan).

El Ecoturismo en los Humedales: Análisis de las Potencialidades de República Dominicana

Directory of Open Access Journals (Sweden)

Francisco Orgaz Agüera

2014-04-01

Full Text Available El turismo se configura como uno de los principales motores económicos de República Dominicana. En este sentido, el turismo de sol y playa es la principal tipología turística en el país. Aunque, República Dominicana cuenta con numerosas potencialidades turísticas para poner en marchas nuevas formas de turismo: Turismo gastronómico, turismo ornitológico, turismo cultural, ecoturismo, etc. El principal objetivo de esta investigación es analizar las potencialidades existentes en República Dominicana para desarrollar el ecoturismo en las zonas de humedales. La metodología ha consistido en un trabajo de campo, a través de las entrevistas, los grupos de discusión y la observación participante. Los resultados muestran las grandes potencialidades que tiene el país para desarrollar el ecoturismo en los humedales, y contribuir así, al desarrollo socioeconómico de las comunidades locales. 

Identification of new isolates of Bacillus thuringiensis using rep-PCR products and delta-endotoxin electron microscopy

Directory of Open Access Journals (Sweden)

A.S.G. Lima

2002-01-01

Full Text Available PCR has been used to analyze the distribution of REP (Repetitive Extragenic Palindromic and ERIC (Enterobacterial Repetitive Intergenic Consensus sequences (rep-PCR found within the genome of the bacterium Bacillus thuringiensis, with the purpose to analyze the genetic similarities among 56 subspecies samples and 95 field isolates. The PCR products were analyzed by EB-AGE (ethidium bromide-agarose electrophoresis and then submitted to banding comparisons, based on the Phyllip software algorithm. When the banding similarities were considered for comparison purposes among all the strains, the phylogenic tree patterns varied according to the rep-PCR primers considered, but, from a broader point of view, the ERIC sequences produced better results, which, together with electron microscopy analysis of the released parasporal bodies and colony morphology characteristics, allowed to detect two possible new subspecies of B. thuringiensis.

INTS3 controls the hSSB1-mediated DNA damage response

OpenAIRE

Skaar, Jeffrey R.; Richard, Derek J.; Saraf, Anita; Toschi, Alfredo; Bolderson, Emma; Florens, Laurence; Washburn, Michael P.; Khanna, Kum Kum; Pagano, Michele

2009-01-01

Human SSB1 (single-stranded binding protein 1 [hSSB1]) was recently identified as a part of the ataxia telangiectasia mutated (ATM) signaling pathway. To investigate hSSB1 function, we performed tandem affinity purifications of hSSB1 mutants mimicking the unphosphorylated and ATM-phosphorylated states. Both hSSB1 mutants copurified a subset of Integrator complex subunits and the uncharacterized protein LOC58493/c9orf80 (henceforth minute INTS3/hSSB-associated element [MISE]). The INTS3?MISE?h...

Analysis of steam line break of SMART using RETRAN-3D/INT

International Nuclear Information System (INIS)

Kim, Tae-Wan; Kim, Jong-Won; Park, Goon-Cherl

2003-01-01

RETRAN-3D has been modified to be suitable to safety analysis for integral type marine reactor with modular helical-coiled steam generator cassettes. The modified RETRAN-3D, RETRAN-3D/INT, has helical coil heat conductor model and heat transfer coefficient models for tube and shell sides of helical-coiled steam generator. In addition, moving models are added to simulate the effect of ship motions such as inclination, heaving, rolling and so on. RETRAN-3D/INT has been verified with natural circulation experiment conducted in Seoul National University and the analysis results for the first Japanese nuclear ship, MUTSU. In this study, the safety analysis for SMART, which has been developed by Korea Atomic Energy Research Institute, is performed to examine the applicability of RETRAN-3D/INT to the safety analysis of SMART. The steam line break is selected as reference case. The break type is assumed to the guillotine break. The loss of offsite power is considered as a coincident event and the failure of single train of passive residual heat removal system is assumed as single failure. From the results, it is found that RETRAN-3D/INT can appropriately simulate the transient of SMART and the improvement of non-condensable gas model is required. (author)

REP Executive Education focuses on Midwest plant off-site emergency preparedness

OpenAIRE

Center for Homeland Defense and Security

2015-01-01

Center for Homeland Defense and Security News and Stories, PRESS RELEASES The Center for Homeland Defense and Security burgeoning Radiological Emergency Preparedness (REP) Executive Education Program convened June 8-12 with a special focus on emergency preparedness policy and strategic issues for...

Therapeutic Antiviral Effect of the Nucleic Acid Polymer REP 2055 against Persistent Duck Hepatitis B Virus Infection

Science.gov (United States)

Noordeen, Faseeha; Scougall, Catherine A.; Grosse, Arend; Qiao, Qiao; Ajilian, Behzad B.; Reaiche-Miller, Georget; Finnie, John; Werner, Melanie; Broering, Ruth; Schlaak, Joerg F.; Vaillant, Andrew; Jilbert, Allison R.

2015-01-01

Previous studies have demonstrated that nucleic acid polymers (NAPs) have both entry and post-entry inhibitory activity against duck hepatitis B virus (DHBV) infection. The inhibitory activity exhibited by NAPs prevented DHBV infection of primary duck hepatocytes in vitro and protected ducks from DHBV infection in vivo and did not result from direct activation of the immune response. In the current study treatment of primary human hepatocytes with NAP REP 2055 did not induce expression of the TNF, IL6, IL10, IFNA4 or IFNB1 genes, confirming the lack of direct immunostimulation by REP 2055. Ducks with persistent DHBV infection were treated with NAP 2055 to determine if the post-entry inhibitory activity exhibited by NAPs could provide a therapeutic effect against established DHBV infection in vivo. In all REP 2055-treated ducks, 28 days of treatment lead to initial rapid reductions in serum DHBsAg and DHBV DNA and increases in anti-DHBs antibodies. After treatment, 6/11 ducks experienced a sustained virologic response: DHBsAg and DHBV DNA remained at low or undetectable levels in the serum and no DHBsAg or DHBV core antigen positive hepatocytes and only trace amounts of DHBV total and covalently closed circular DNA (cccDNA) were detected in the liver at 9 or 16 weeks of follow-up. In the remaining 5/11 REP 2055-treated ducks, all markers of DHBV infection rapidly rebounded after treatment withdrawal: At 9 and 16 weeks of follow-up, levels of DHBsAg and DHBcAg and DHBV total and cccDNA in the liver had rebounded and matched levels observed in the control ducks treated with normal saline which remained persistently infected with DHBV. These data demonstrate that treatment with the NAP REP 2055 can lead to sustained control of persistent DHBV infection. These effects may be related to the unique ability of REP 2055 to block release of DHBsAg from infected hepatocytes. PMID:26560490

Interaction sol-structure : Ponts à culées intégrales

OpenAIRE

Dreier, Damien; Muttoni, Aurelio

2010-01-01

Depuis quelques décennies, la part de ponts intégraux dans les nouveaux ouvrages n’a cessé d’augmenter. L’intérêt croissant pour ce type de construction se justifie par leurs nombreux avantages en comparaison avec les ponts équipés de joints de dilatation et d’appuis mécaniques. L’avantage principal est une demande de maintenance fortement réduite, les éléments mécaniques les plus sensibles aux actions mécaniques et environnementa...

RiskREP: Risk-Based Security Requirements Elicitation and Prioritization (extended version)

NARCIS (Netherlands)

Herrmann, Andrea; Morali, A.

2010-01-01

Today, companies are required to be in control of the security of their IT assets. This is especially challenging in the presence of limited budgets and conflicting requirements. Here, we present Risk-Based Requirements Elicitation and Prioritization (RiskREP), a method for managing IT security

Averróis e a República de Platão

Directory of Open Access Journals (Sweden)

Pereira, Rosalie Helena de Souza

2007-01-01

Full Text Available Sobre República é o único comentário de uma obra de Platão deixado por Averróis, o comentador por antonomásia, diga-se de Aristóteles. Embora se tenha perdido o original árabe, a teles. Embora se tenha perdido o original árabe, a posteridade recebeu uma versão hebraíca e duas latinas. O comentário (ou paráfrase a República de Platão pode ser considerado uma obra original - divida em três livros - já que apenas um terço dela corresponde ao texto platônico. Além de apresentar conceitos aristotélicos retirados da Ética Nicomaquéia e de obras políticas de Al-Farabi, Averróis apresenta reflexões próprias e faz críticas à sociedade em que vive

El montaje de la transición argentina. Un análisis de los films La República perdida, La República perdida II y Evita, quien quiera oír que oiga

Directory of Open Access Journals (Sweden)

Paola Judith Margulis

2012-01-01

Full Text Available El presente artículo se propone reconstruir una zona de la historia del documental argentino a partir del abordaje de tres films que tuvieron un alto impacto en Argentina hacia la transición democrática: La República perdida (Miguel Pérez, 1983, su secuela La República perdida II (Miguel Pérez, 1986 y Evita, quien quiera oír que oiga (Eduardo Mignogna, 1984. Dada la importancia de estos films -tanto en términos políticos como de impacto en el público-, intentaremos situarlos en contexto y analizar algunos aspectos inherentes a su lógica fílmica.

CoolRep H22: Synthesis report on R and D results on geological disposal up to 2009

International Nuclear Information System (INIS)

Umeki, Hiroyuki; Hioki, Kazumasa; Osawa, Hideaki; Fujita, Tomoo; Shibata, Masahiro; Makino, Hitoshi; Takeuchi, Shinji; Ishimaru, Tsuneari

2011-02-01

The Japan Atomic Energy Agency (JAEA) has been performing research and development on geological disposal technology of high level radioactive waste. At the end of fiscal year 2009, the Geological Isolation Research and Development Directorate of JAEA made publicly available the 'CoolRep H22', which is a web-based report that summarizes the R and D results, on its website. This document reports the contents of CoolRep H22. (author)

L’intégration scolaire des enfants handicapés en France: Etat du problème

OpenAIRE

Tomkiewicz, Stanislaw

1991-01-01

Le principe de l’intégration scolaire des enfants handicapés, posé en 1975, a fait naître de grands espoirs et de grandes craintes surtout après 1982. J’ai examiné ici l’état de l’intégration en 1989, ses avantages et ses dangers, les résistances des différents groupes intéressés et les limites de la politique intégrative. RESUMO: O principio da integraçâo escolar das crianças com di ficuldades, colocada em 1975, fez aparecer grandes esperanças e grandes crenças, so...

Iberia : capital federal de la IIª República Española (Un proyecto de Rubio i Tuduri

Directory of Open Access Journals (Sweden)

Carlos Sambricio

1996-01-01

Full Text Available A los pocos meses de proclamarse, en 1931, la II República Española, Nicolás Rubio i Tuduri presentaba —en el marco de la Exposición organizada por la Asociación de Arquitectos de Cataluña, celebrada en la barcelonesa Galería Maragall— una propuesta un tanto sorprendente: el proyecto de una nueva Capital Federal de la República Española que él denominaba Iberia.

Preliminary report on hepatic and cardiovascular risk assessment of ...

African Journals Online (AJOL)

user

2011-02-28

Feb 28, 2011 ... not at greater risk of disruption of their plasma membrane ... supplementing soy protein with acetate generating amino acids. Nutr. Rep. Int. 40: ... Effects of fruits and vegetables on cardiovascular disease ris factors in non-.

Production of propylene from 1-butene on highly active "bi-functional single active site" catalyst: Tungsten carbene-hydride supported on alumina

KAUST Repository

Mazoyer, Etienne; Szeto, Kaï Chung; Norsic, Sé bastien; Garron, Anthony; Basset, Jean-Marie; Nicholas, Christopher P.; Taoufik, Mostafa

2011-01-01

1-Butene is transformed in a continuous flow reactor over tungsten hydrides precursor W-H/Al2O3, 1, giving a promising yield into propylene at 150 °C and different pressures. Tungsten carbene-hydride single active site operates as a "bi

The RXL motif of the African cassava mosaic virus Rep protein is necessary for rereplication of yeast DNA and viral infection in plants

Energy Technology Data Exchange (ETDEWEB)

Hipp, Katharina; Rau, Peter; Schäfer, Benjamin [Institut für Biomaterialien und biomolekulare Systeme, Abteilung für Molekularbiologie und Virologie der Pflanzen, Universität Stuttgart, Pfaffenwaldring 57, D-70550 Stuttgart (Germany); Gronenborn, Bruno [Institut des Sciences du Végétal, CNRS, 91198 Gif-sur-Yvette (France); Jeske, Holger, E-mail: holger.jeske@bio.uni-stuttgart.de [Institut für Biomaterialien und biomolekulare Systeme, Abteilung für Molekularbiologie und Virologie der Pflanzen, Universität Stuttgart, Pfaffenwaldring 57, D-70550 Stuttgart (Germany)

2014-08-15

Geminiviruses, single-stranded DNA plant viruses, encode a replication-initiator protein (Rep) that is indispensable for virus replication. A potential cyclin interaction motif (RXL) in the sequence of African cassava mosaic virus Rep may be an alternative link to cell cycle controls to the known interaction with plant homologs of retinoblastoma protein (pRBR). Mutation of this motif abrogated rereplication in fission yeast induced by expression of wildtype Rep suggesting that Rep interacts via its RXL motif with one or several yeast proteins. The RXL motif is essential for viral infection of Nicotiana benthamiana plants, since mutation of this motif in infectious clones prevented any symptomatic infection. The cell-cycle link (Clink) protein of a nanovirus (faba bean necrotic yellows virus) was investigated that activates the cell cycle by binding via its LXCXE motif to pRBR. Expression of wildtype Clink and a Clink mutant deficient in pRBR-binding did not trigger rereplication in fission yeast. - Highlights: • A potential cyclin interaction motif is conserved in geminivirus Rep proteins. • In ACMV Rep, this motif (RXL) is essential for rereplication of fission yeast DNA. • Mutating RXL abrogated viral infection completely in Nicotiana benthamiana. • Expression of a nanovirus Clink protein in yeast did not induce rereplication. • Plant viruses may have evolved multiple routes to exploit host DNA synthesis.

The RXL motif of the African cassava mosaic virus Rep protein is necessary for rereplication of yeast DNA and viral infection in plants

International Nuclear Information System (INIS)

Hipp, Katharina; Rau, Peter; Schäfer, Benjamin; Gronenborn, Bruno; Jeske, Holger

2014-01-01

Geminiviruses, single-stranded DNA plant viruses, encode a replication-initiator protein (Rep) that is indispensable for virus replication. A potential cyclin interaction motif (RXL) in the sequence of African cassava mosaic virus Rep may be an alternative link to cell cycle controls to the known interaction with plant homologs of retinoblastoma protein (pRBR). Mutation of this motif abrogated rereplication in fission yeast induced by expression of wildtype Rep suggesting that Rep interacts via its RXL motif with one or several yeast proteins. The RXL motif is essential for viral infection of Nicotiana benthamiana plants, since mutation of this motif in infectious clones prevented any symptomatic infection. The cell-cycle link (Clink) protein of a nanovirus (faba bean necrotic yellows virus) was investigated that activates the cell cycle by binding via its LXCXE motif to pRBR. Expression of wildtype Clink and a Clink mutant deficient in pRBR-binding did not trigger rereplication in fission yeast. - Highlights: • A potential cyclin interaction motif is conserved in geminivirus Rep proteins. • In ACMV Rep, this motif (RXL) is essential for rereplication of fission yeast DNA. • Mutating RXL abrogated viral infection completely in Nicotiana benthamiana. • Expression of a nanovirus Clink protein in yeast did not induce rereplication. • Plant viruses may have evolved multiple routes to exploit host DNA synthesis

RiskREP: Risk-Based Security Requirements Elicitation and Prioritization

OpenAIRE

Herrmann, Andrea; Morali, A.; Etalle, Sandro; Wieringa, Roelf J.; Niedrite, Laila; Strazdina, Renate; Wangler, Benkt

2011-01-01

Companies are under pressure to be in control of their assets but at the same time they must operate as efficiently as possible. This means that they aim to implement “good-enough security‿ but need to be able to justify their security investment plans. In this paper, we present a Risk-Based Requirements Prioritization method (RiskREP) that extends misuse case-based methods with IT architecture based risk assessment and countermeasure definition and prioritization. Countermeasure prioritizati...

Revolución versus reforma educativa en la segunda república española. Elementos de ruptura

Directory of Open Access Journals (Sweden)

Juan Manuel FERNÁNDEZ SORIA

2010-03-01

Full Text Available RESUMEN: Están fuera de toda duda las conexiones existentes entre la República de 1931-35 y la de 1936-39. En este sentido estamos de acuerdo con quienes afirman que el estallido de la guerra del 36 es el resultado de un proceso que arranca del mismo año en que se proclama la II República, iniciándose ya entonces —como sostiene Andrés M. Kramer— la «mecánica de guerra civil». La educación republicana en tiempo de guerra no puede quedar fuera de esta consideración, porque aquélla sumerge sus cimientos más profundos en la política educativa de 1931-35. Efectivamente, muchas de las acciones educativas y culturales llevadas a cabo durante la guerra no tendrían fácil explicación si no se examina previamente la tarea de la República del 31 en estos mismos aspectos.

Discriminação de sorovares de Salmonella spp. isolados de carcaças de frango por REP e ERIC-PCR e fagotipagem do sorovar Enteriditis Discrimination of Salmonella serovars isolated from chicken meat by REP and ERIC-PCR and phagotyping of Enteriditis sorovar

Directory of Open Access Journals (Sweden)

Iliana Alcocer

2006-06-01

Full Text Available Salmonelose é a infecção bacteriana de origem alimentar mais freqüente no Paraná, Brasil, e os surtos estão associados, principalmente, ao consumo de ovos, carne de aves e derivados. Os objetivos deste trabalho foram identificar os sorovares de Salmonella isolados de carcaças de frango e caracterizá-los molecularmente por REP e ERIC-PCR, assim como identificar os fagotipos de Salmonella Enteriditis. Dos 25 isolados de Salmonella spp. analisados, 18 foram identificados como Enteriditis, 4 como Braenderup, 2 como Worthington e 1 como infantis. Dos 18 isolados de Enteriditis, 14 foram PT4, 2 PT4a, 1 PT7 e 1 RDNC, por se tratar de colônia rugosa. REP-PCR forneceu padrão eletroforético distinto de 10 a 13 bandas distribuídas entre 120 e 2072 pb para cada sorovar diferente testado. A ERIC-PCR mostrou um padrão de 4 a 5 bandas entre 180 e 1000 pb e foi menos discriminativa quando comparada à REP-PCR. Os resultados encontrados confirmaram que a fagotipagem é uma ferramenta útil e discriminativa para o sorovar Enteriditis. Apesar do pequeno número de sorovares testados, os resultados sugerem que a REP-PCR parece ser um método atrativo a ser utilizado no futuro para a discriminação preliminar de sorovares de Salmonella.Salmonellosis is the most prevalent bacterial food-borne disease in the State of Paraná, Brazil, and the outbreaks are often associated with consumption of poultry products. The aim of this study was to serotype Salmonella strains isolated from chicken carcasses and characterize them molecularly using REP and ERIC-PCR. The phage types of Salmonella Enteriditis were also identified. Of the 25 Salmonella strains analysed, 18 were identified as Enteriditis, 4 as Braenderup, 2 as Worthington and 1 as infantis. Of the 18 Enteriditis isolates, 14 were PT4, 2 PT4a, 1 PT7 and 1 "reacted, but did not conform" - RDNC. Distinct REP-PCR profiles with 10 to 13 fragments distributed between 120 and 2072 pb were easily obtained for

A repA-based ELISA for discriminating cattle vaccinated with Brucella suis 2 from those naturally infected with Brucella abortus and Brucella melitensis.

Science.gov (United States)

Wang, Jing-Yu; Wu, Ning; Liu, Wan-Hua; Ren, Juan-Juan; Tang, Pan; Qiu, Yuan-Hao; Wang, Chi-Young; Chang, Ching-Dong; Liu, Hung-Jen

2014-01-01

The commonest ways of diagnosing brucellosis in animals include the Rose-Bengal plate agglutination test, the buffered plate agglutination test (BPA), the slide agglutination test, the complement fixation test, and the indirect enzyme linked immunosorbent assay (I-ELISA). However, these methods cannot discriminate the Brucella vaccine strain (Brucella suis strain 2; B. suis S2) from naturally acquired virulent strains. Of the six common Brucella species, Brucella melitensis, Brucella abortus, and B. suis are the commonest species occurring in China. To develop an ELISA assay that can differentiate between cows inoculated with B. suis S2 and naturally infected with B. abortus and B. melitensis, genomic sequences from six Brucella spp. (B. melitensis, B. abortus, B. suis, Brucella canis, Brucella neotomae and Brucella ovis) were compared using Basic Local Alignment Search Tool software. One particular gene, the repA-related gene, was found to be a marker that can differentiate B. suis from B. abortus and B. melitensis. The repA-related gene of B. suis was PCR amplified and subcloned into the pET-32a vector. Expressed repA-related protein was purified and used as an antigen. The repA-based ELISA was optimized and used as specific tests. In the present study, serum from animals inoculated with the B. suis S2 vaccine strain had positive repA-based ELISA results. In contrast, the test-positive reference sera against B. abortus and B. melitensis had negative repA-based ELISA results. The concordance rate between B. abortus antibody-negative (based on the repA-based ELISA) and the Brucella gene-positive (based on the 'Bruce ladder' multiplex PCR) was 100%. Therefore, the findings suggest that the repA-based ELISA is a useful tool for differentiating cows vaccinated with the B. suis S2 and naturally infected with B. abortus and B. melitensis. Copyright © 2014 Elsevier Ltd. All rights reserved.

Progressive Conversion from B-rep to BSP for Streaming Geometric Modeling.

Science.gov (United States)

Bajaj, Chandrajit; Paoluzzi, Alberto; Scorzelli, Giorgio

2006-01-01

We introduce a novel progressive approach to generate a Binary Space Partition (BSP) tree and a convex cell decomposition for any input triangles boundary representation (B-rep), by utilizing a fast calculation of the surface inertia. We also generate a solid model at progressive levels of detail. This approach relies on a variation of standard BSP tree generation, allowing for labeling cells as in, out and fuzzy, and which permits a comprehensive representation of a solid as the Hasse diagram of a cell complex. Our new algorithm is embedded in a streaming computational framework, using four types of dataflow processes that continuously produce, transform, combine or consume subsets of cells depending on their number or input/output stream. A varied collection of geometric modeling techniques are integrated in this streaming framework, including polygonal, spline, solid and heterogeneous modeling with boundary and decompositive representations, Boolean set operations, Cartesian products and adaptive refinement. The real-time B-rep to BSP streaming results we report in this paper are a large step forward in the ultimate unification of rapid conceptual and detailed shape design methodologies.

Appel à manifestations d'intérêt

International Development Research Centre (IDRC) Digital Library (Canada)

gprudhomme

17 mars 2014 ... ... de santé, les soins de santé primaires, la santé des mères et des enfants et la ..... général des points ci-dessous à l'étape de la manifestation d'intérêt. ..... font désormais appel à des cliniciens autres que des médecins pour.

Análisis de la relación comercial entre la República de Colombia y la República de Costa Rica

OpenAIRE

Romero Escobar, Juán Sebastián; Bermudez Monroy, María Gabriela

2012-01-01

Dadas las relaciones de cooperación internacional que presentan las Repúblicas de Colombia y Costa Rica, que se evidencia en los fuertes vínculos comerciales existentes entre las dos naciones, Proexport por medio de su oficina comercial en Costa Rica, ha mantenido al tanto la situación en la que se desenvuelve la alianza comercial entre Colombia y Costa Rica. Él último de estos informes, demuestra la potencialidad de Costa Rica como un mercado para los bienes colombianos y una posibilidad par...

IntNetLncSim: an integrative network analysis method to infer human lncRNA functional similarity.

Science.gov (United States)

Cheng, Liang; Shi, Hongbo; Wang, Zhenzhen; Hu, Yang; Yang, Haixiu; Zhou, Chen; Sun, Jie; Zhou, Meng

2016-07-26

Increasing evidence indicated that long non-coding RNAs (lncRNAs) were involved in various biological processes and complex diseases by communicating with mRNAs/miRNAs each other. Exploiting interactions between lncRNAs and mRNA/miRNAs to lncRNA functional similarity (LFS) is an effective method to explore function of lncRNAs and predict novel lncRNA-disease associations. In this article, we proposed an integrative framework, IntNetLncSim, to infer LFS by modeling the information flow in an integrated network that comprises both lncRNA-related transcriptional and post-transcriptional information. The performance of IntNetLncSim was evaluated by investigating the relationship of LFS with the similarity of lncRNA-related mRNA sets (LmRSets) and miRNA sets (LmiRSets). As a result, LFS by IntNetLncSim was significant positively correlated with the LmRSet (Pearson correlation γ2=0.8424) and LmiRSet (Pearson correlation γ2=0.2601). Particularly, the performance of IntNetLncSim is superior to several previous methods. In the case of applying the LFS to identify novel lncRNA-disease relationships, we achieved an area under the ROC curve (0.7300) in experimentally verified lncRNA-disease associations based on leave-one-out cross-validation. Furthermore, highly-ranked lncRNA-disease associations confirmed by literature mining demonstrated the excellent performance of IntNetLncSim. Finally, a web-accessible system was provided for querying LFS and potential lncRNA-disease relationships: http://www.bio-bigdata.com/IntNetLncSim.

CARACTERIZACIÓN MOLECULAR MEDIANTE rep-PCR DE AISLADOS NATIVOS DE Bacillus thuringiensis, OBTENIDOS DE MUESTRAS DE SUELO

Directory of Open Access Journals (Sweden)

Fabián Galvis

2014-01-01

Full Text Available Bacillus thuringiensis es una bacteria Gram-positiva formadora de esporas, que produ - ce cristales parasporales de naturaleza proteica, tóxicos contra diferentes órdenes de insectos y biodegradables e inocuos para otras especies. Esta investigación empleó el modelo experimen - tal, que mediante técnicas de observación permi - tió, la identificación microbiológica y bioquímica de B. thuringiensis a partir de muestras de suelo de los municipios de Cúcuta, El Zulia, Los Patios, San Cayetano y Villa del Rosario, Norte de Santander, Colombia, y su posterior caracteri - zación con los marcadores moleculares Bc-Rep y MB1. Se identificaron microbiológica y bioquí - micamente 10 aislados como B. thuringiensis ; los resultados del análisis filogenético mostraron diferencias significativas en los agrupamientos obtenidos con los marcadores Bc-Rep y MB1. Con Bc-Rep se registró un índice de similaridad bajo (18%, mientras que con el marcador MB1 se obtuvo un índice mayor de similitud, 58%. En este trabajo se evidenció una gran variabilidad genética entre los aislados, que mostraron a los marcadores Bc-Rep y MB1 como altamente efectivos para diferenciar cepas estrechamente relacionadas, convirtiéndose en una herramienta genética de gran valor para estudios de identifi-cación y diversidad en B. thuringiensis.

Ultra Fast, High Rep Rate, High Voltage Spark Gap Pulser

Science.gov (United States)

1995-07-01

current rise time. The spark gap was designed to have a coaxial geometry reducing its inductance. Provisions were made to pass flowing gas between the...ULTRA FAST, HIGH REP RATE, HIGH VOLTAGE SPARK GAP PULSER Robert A. Pastore Jr., Lawrence E. Kingsley, Kevin Fonda, Erik Lenzing Electrophysics and...Modeling Branch AMSRL-PS-EA Tel.: (908)-532-0271 FAX: (908)-542-3348 U.S. Army Research Laboratory Physical Sciences Directorate Ft. Monmouth

Variation in a surface-exposed region of the Mycoplasma pneumoniae P40 protein as a consequence of homologous DNA recombination between RepMP5 elements.

Science.gov (United States)

Spuesens, Emiel B M; van de Kreeke, Nick; Estevão, Silvia; Hoogenboezem, Theo; Sluijter, Marcel; Hartwig, Nico G; van Rossum, Annemarie M C; Vink, Cornelis

2011-02-01

Mycoplasma pneumoniae is a human pathogen that causes a range of respiratory tract infections. The first step in infection is adherence of the bacteria to the respiratory epithelium. This step is mediated by a specialized organelle, which contains several proteins (cytadhesins) that have an important function in adherence. Two of these cytadhesins, P40 and P90, represent the proteolytic products from a single 130 kDa protein precursor, which is encoded by the MPN142 gene. Interestingly, MPN142 contains a repetitive DNA element, termed RepMP5, of which homologues are found at seven other loci within the M. pneumoniae genome. It has been hypothesized that these RepMP5 elements, which are similar but not identical in sequence, recombine with their counterpart within MPN142 and thereby provide a source of sequence variation for this gene. As this variation may give rise to amino acid changes within P40 and P90, the recombination between RepMP5 elements may constitute the basis of antigenic variation and, possibly, immune evasion by M. pneumoniae. To investigate the sequence variation of MPN142 in relation to inter-RepMP5 recombination, we determined the sequences of all RepMP5 elements in a collection of 25 strains. The results indicate that: (i) inter-RepMP5 recombination events have occurred in seven of the strains, and (ii) putative RepMP5 recombination events involving MPN142 have induced amino acid changes in a surface-exposed part of the P40 protein in two of the strains. We conclude that recombination between RepMP5 elements is a common phenomenon that may lead to sequence variation of MPN142-encoded proteins.

How Often Is p[subscript rep] Close to the True Replication Probability?

Science.gov (United States)

Trafimow, David; MacDonald, Justin A.; Rice, Stephen; Clason, Dennis L.

2010-01-01

Largely due to dissatisfaction with the standard null hypothesis significance testing procedure, researchers have begun to consider alternatives. For example, Killeen (2005a) has argued that researchers should calculate p[subscript rep] that is purported to indicate the probability that, if the experiment in question were replicated, the obtained…

Birmingham Rep, Youth and Community, and the Products and Possibilities of Precarity

Science.gov (United States)

Cochrane, Claire

2017-01-01

Birmingham Rep, a leading producing theatre based in the UK's "second city", has historically had a complex relationship with the cultural priorities of its home city. In recent years, Birmingham City Council has faced multiple challenges represented by debt burden, government-imposed cuts in public funding, scandals linked to failing…

Control conception for REP 1300 MW units of the Electricite de France

International Nuclear Information System (INIS)

Blanc, P.; Guesnier, G.

1986-01-01

The paper describes the control equipment for the REP 1300 MW units including the reactor protection system, the control rods drive system and nuclear instrumentation, the control of the auxiliaries in the systems important for the reactor safety and the safety survey computer. Finally, the digital connections between different control systems are presented

A formação do intérprete educacional e sua atuação em sala de aula

Directory of Open Access Journals (Sweden)

Luiz Cláudio Oliveira Antonio

2015-10-01

Full Text Available É fundamental contar com a participação do intérprete educacional de Língua de Sinais (LS na inclusão. Esse artigo aborda a formação e as diferentes funções dos intérpretes em contextos educacionais inclusivos. Basta ser conhecedor da LS? Isso garante ao intérprete o sucesso em sua função? É preciso também agir como mediador entre professor e os alunos surdos, buscando promover a compreensão. Nessa pesquisa foram realizadas entrevistas semiestruturadas com onze intérpretes que atuam na inclusão, buscando conhecer a formação inicial, o tempo de exercício profissional, quais as motivações e quais as funções que desempenha na sala de aula e na escola. Resultados apontam a ausência de planejamento conjunto professor-intérprete e de acesso prévio aos conteúdos apresentados em sala. Verificou-se que quando o intérprete age pedagogicamente, crianças surdas aprendem mais.

O tradutor/intérprete de língua de sinais: um mediador de fronteiras culturais

Directory of Open Access Journals (Sweden)

Izaulita César Moura

2017-01-01

Full Text Available Discute-se a importância do tradutor/intérprete de Língua de Sinais enquanto um mediador de fronteiras entre dois mundos culturais. Busca-se dar visibilidade à complexidade da tarefa do intérprete não apenas no campo da linguagem, mas também na área da subjetividade, levando em conta contribuições da Psicanálise. Partiu-se de uma pesquisa qualitativa realizada no Instituto Nacional de Educação de Surdos que abordou o tema da linguagem e subjetividade com alunos com surdez profunda. Concluiu-se que o papel social e subjetivo do intérprete de Libras precisa ser mais bem compreendido. O desafio não é apenas traduzir e informar, mas saber guardar os próprios pensamentos e sentimentos, para ser porta voz da fala, da expressão e da emoção de outra pessoa, de um sujeito que se manifesta em total alteridade. Assim, facetas menos conhecidas do papel intersubjetivo do tradutor/intérprete são apontadas.

SEATURTLE: Sustained Engagement Autonomous Tracking of Underwater RepTiLEs

OpenAIRE

Budd, Johnathan

2015-01-01

While oceans cover the majority of our planet, these vast expanses remain relatively unexplored. Among the most interesting parts of the ocean are the shallow reef systems, which contain a huge amount of the planet’s biodiversity. The Sustained Engagement Autonomous Tracking of Underwater RepTiLEs or SEATURTLE is a low cost Autonomous Underwater Vehicle designed to carry out missions in these shallow environments. Its small displacement and precise movement make it ideal for navigating tight ...

BioInt: an integrative biological object-oriented application framework and interpreter.

Science.gov (United States)

Desai, Sanket; Burra, Prasad

2015-01-01

BioInt, a biological programming application framework and interpreter, is an attempt to equip the researchers with seamless integration, efficient extraction and effortless analysis of the data from various biological databases and algorithms. Based on the type of biological data, algorithms and related functionalities, a biology-specific framework was developed which has nine modules. The modules are a compilation of numerous reusable BioADTs. This software ecosystem containing more than 450 biological objects underneath the interpreter makes it flexible, integrative and comprehensive. Similar to Python, BioInt eliminates the compilation and linking steps cutting the time significantly. The researcher can write the scripts using available BioADTs (following C++ syntax) and execute them interactively or use as a command line application. It has features that enable automation, extension of the framework with new/external BioADTs/libraries and deployment of complex work flows.

Overview of RepLab 2014: Author Profiling and Reputation Dimensions for Online Reputation Management

NARCIS (Netherlands)

Amigó, E.; Carrillo-de-Albornoz, J.; Chugur, I.; Corujo, A.; Gonzalo, J.; Meij, E.; de Rijke, M.; Spina, D.; Kanoulas, E.; Lupu, M.; Clough, P.; Sanderson, M.; Hall, M.; Hanbury, A.; Toms, E.

2014-01-01

This paper describes the organisation and results of RepLab 2014, the third competitive evaluation campaign for Online Reputation Management systems. This year the focus lied on two new tasks: reputation dimensions classification and author profiling, which complement the aspects of reputation

Automated Production of High Rep Rate Foam Targets

Science.gov (United States)

Hall, F.; Spindloe, C.; Haddock, D.; Tolley, M.; Nazarov, W.

2016-04-01

Manufacturing low density targets in the numbers needed for high rep rate experiments is highly challenging. This report summarises advances from manual production to semiautomated and the improvements that follow both in terms of production time and target uniformity. The production process is described and shown to be improved by the integration of an xyz robot with dispensing capabilities. Results are obtained from manual and semiautomated production runs and compared. The variance in the foam thickness is reduced significantly which should decrease experimental variation due to target parameters and could allow for whole batches to be characterised by the measurement of a few samples. The work applies to both foil backed and free standing foam targets.

Investigation of Genetic Diversity of Wilsonomyces carpophilus in Khorasan Razavi Using rep-PCR Marker

Directory of Open Access Journals (Sweden)

R. Barazandeh Aq Kariz

2017-08-01

Full Text Available Introduction: Shot hole disease of stone fruit trees resulted from Wilsonomyces carpophilus can weaken the trees and reduce the quantity and quality of the crops worldwide particularly in semi-arid regions. Coryneum blight or shot hole disease infects all the stone fruit trees including peach, nectarine, apricot, sour cherry, plum, cherry, and almond. One of the most important strategies to manage any plant disease is to use resistant cultivars. In this way, it is very important to have knowledge about the status of genetic diversity and to determine the relationship between isolates of the causal agent fungus. The main objective of the present research was to study the genetic diversity of W. carpophilus in Khorasan Razavi province using the rep-PCR molecular fingerprinting method. Materials and Methods: Sampling was performed from peach, nectarine, plum, apricot and cherry orchards of Quchan, Torqabeh, Shandiz, Chenaran, Neishabur, Kalat, Torbat Heidarieh and Mashhad during spring and summer of 2012 and 2013. Mono-conidial isolates were recovered from infected leaves, fruits, and twigs of different parts of orchards. Infected collected leaves, twigs, and fruits were transferred to the laboratory. By using techniques of Klimesova and Prasil (1989 and Mehta (1998 from the cut parts between infected and healthy tissues of each isolate, cuts of 2-3 mm from leaf, fruit and twig were prepared by the scalpel. These pieces were surface sterilized with 1% sodium hypochlorite liquid about 1 to 3 minutes based on the thickness of tissue. Then, the samples were cultured on PDA, MEA, and WA media and incubated at 18, 20, and 25 °C. The isolated fungi were purified and identified. The research was performed on 20 fungal isolates collected from different stone fruit trees. Genomic DNA was amplified using BOX A1R, ERIC2, ERIC1R, REP2-I, and REP1R-I primers. Thirty-eight of 39 fragments amplified were polymorphic for 100 to 5000 base pairs. Similarity matrix

RepExplore: addressing technical replicate variance in proteomics and metabolomics data analysis.

Science.gov (United States)

Glaab, Enrico; Schneider, Reinhard

2015-07-01

High-throughput omics datasets often contain technical replicates included to account for technical sources of noise in the measurement process. Although summarizing these replicate measurements by using robust averages may help to reduce the influence of noise on downstream data analysis, the information on the variance across the replicate measurements is lost in the averaging process and therefore typically disregarded in subsequent statistical analyses.We introduce RepExplore, a web-service dedicated to exploit the information captured in the technical replicate variance to provide more reliable and informative differential expression and abundance statistics for omics datasets. The software builds on previously published statistical methods, which have been applied successfully to biomedical omics data but are difficult to use without prior experience in programming or scripting. RepExplore facilitates the analysis by providing a fully automated data processing and interactive ranking tables, whisker plot, heat map and principal component analysis visualizations to interpret omics data and derived statistics. Freely available at http://www.repexplore.tk enrico.glaab@uni.lu Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press.

Démarche intégrée pour assurer la sécurité alimentaire et ...

International Development Research Centre (IDRC) Digital Library (Canada)

Démarche intégrée pour assurer la sécurité alimentaire et nutritionnelle aux Philippines. La malnutrition demeure un problème grave aux Philippines, notamment chez les enfants. La mise en place de programmes intégrés de nutrition et de culture potagère dans les écoles pourrait-elle contribuer à remédier à ce problème ...

Repérage d’Images Ordinaires : Analyse des Requêtes des Chercheurs d’Images

Directory of Open Access Journals (Sweden)

Elaine Ménard

2009-06-01

also emphasizes the pressing necessity to optimize the methods used for image processing, in order to facilitate image retrieval and dissemination in multilingual environments. Résumé Depuis quelques années, le web est devenu un média incontournable pour la diffusion de ressources multilingues. Cependant, les différences linguistiques constituent souvent un obstacle majeur aux échanges de documents scientifiques, culturels, pédagogiques et commerciaux. En plus de cette diversité linguistique, on constate le développement croissant de bases de données et de collections composées de différents types de documents textuels ou multimédias, ce qui complexifie également le processus de repérage documentaire. Par exemple, les collections d’images numériques sont aussi nombreuses que diversifiées. Le besoin de repérer une image spécifique dans diverses collections est devenu une préoccupation partagée par plusieurs communautés. La croissance du web a mis en relief le besoin pressant de se doter d’outils propres à la description des images dans le but de faciliter leur repérage, puisque l’on retrouve celles-ci dans la plupart des ressources disponibles. Cette recherche compare le repérage d’images dans deux contextes linguistiques différents : un contexte monolingue, c’est-à-dire que la langue de la requête (français est la même que la langue d’indexation (français; et un contexte multilingue où la langue de la requête (français est différente de la langue d’indexation (anglais. Cet article présente les résultats de l’analyse des requêtes formulées par les participants pour repérer un ensemble d’images ordinaires représentant des objets de la vie quotidienne, en contexte de repérage multilingue. L’examen des termes contenus dans les requêtes des chercheurs d’images révèle les tendances observées sur le plan terminologique, perceptuel et structurel. Les participants emploient généralement des requêtes simples

Use of a rep-PCR system to predict species in the Aspergillus section Nigri

Science.gov (United States)

The Aspergillus niger aggregate within the A. section Nigri, is a group of black-spored aspergilli which taxonomy has been elusive. REP-PCR has become a rapid and cost-effective method for genotyping fungi and bacteria. In the present study, we evaluated the discriminatory power of a semi-automate...

XII — Taux de l’intérêt, taux de l’escompte, prix de l’or

OpenAIRE

Juglar, Clément

2014-01-01

[Taux de l’intérêt à long et à court terme. — Qu’est-ce qui règle le taux de l’intérêt ? — Variations du taux de l’intérêt en France et en Angleterre. — Taux de l’escompte. Écart de prix entre les ventes à terme et les ventes au comptant. — La banque ne commandite pas le travail, elle fait circuler le crédit. — Le taux de capitalisation des rentes ne suit pas le taux de l’escompte. — Influence de la hausse de l’escompte. — Hausse de l’escompte, prix de l’or, flux et reflux des métaux précieux...

Identification of rep-associated factors in herpes simplex virus type 1-induced adeno-associated virus type 2 replication compartments.

Science.gov (United States)

Nicolas, Armel; Alazard-Dany, Nathalie; Biollay, Coline; Arata, Loredana; Jolinon, Nelly; Kuhn, Lauriane; Ferro, Myriam; Weller, Sandra K; Epstein, Alberto L; Salvetti, Anna; Greco, Anna

2010-09-01

Adeno-associated virus (AAV) is a human parvovirus that replicates only in cells coinfected with a helper virus, such as adenovirus or herpes simplex virus type 1 (HSV-1). We previously showed that nine HSV-1 factors are able to support AAV rep gene expression and genome replication. To elucidate the strategy of AAV replication in the presence of HSV-1, we undertook a proteomic analysis of cellular and HSV-1 factors associated with Rep proteins and thus potentially recruited within AAV replication compartments (AAV RCs). This study resulted in the identification of approximately 60 cellular proteins, among which factors involved in DNA and RNA metabolism represented the largest functional categories. Validation analyses indicated that the cellular DNA replication enzymes RPA, RFC, and PCNA were recruited within HSV-1-induced AAV RCs. Polymerase delta was not identified but subsequently was shown to colocalize with Rep within AAV RCs even in the presence of the HSV-1 polymerase complex. In addition, we found that AAV replication is associated with the recruitment of components of the Mre11/Rad50/Nbs1 complex, Ku70 and -86, and the mismatch repair proteins MSH2, -3, and -6. Finally, several HSV-1 factors were also found to be associated with Rep, including UL12. We demonstrated for the first time that this protein plays a role during AAV replication by enhancing the resolution of AAV replicative forms and AAV particle production. Altogether, these analyses provide the basis to understand how AAV adapts its replication strategy to the nuclear environment induced by the helper virus.

Progrès de l'intégration régionale, rôle et stratégie du Groupe de la

International Development Research Centre (IDRC) Digital Library (Canada)

mgv3643

8 déc. 2009 ... 1. Progrès de l‟Intégration Régionale,. Rôle et Stratégie du Groupe de la Banque Africaine de Développement dans la promotion de l‟intégration régionale en Afrique. Gabriel Mougani. Département NEPAD, Intégration Régionale et Commerce ...

Utilisation of Rep-PCR to track microbes in aerosols collected adjacent to their source, a saline lake in Victoria, Australia.

Science.gov (United States)

Munday, Chris I; O'Loingsigh, Tadhg; Tapper, Nigel J; De Deckker, Patrick; Allison, Gwen E

2013-04-15

Dust storms are a major source of aerosolized bacteria, especially in the drought conditions experienced in Australia in the decade to 2009. The major aims of this project were to identify the culturable bacteria in environmental samples and to genetically fingerprint all isolates using repetitive element PCR (Rep-PCR) to investigate the possibility of tracking isolates from their source into the atmosphere. Four field trips were conducted to a dry lake in western Victoria, Australia to sample aerosols and sediments. Aerosols were collected at heights up to 150 m using vacuum pumps with filters attached to a tethered helium balloon, while corresponding sediments were collected in sterile polypropylene tubes. Isolates were cultivated on Tryptic Soy Agar, R2 Agar and Marine Agar, and grown in dark conditions at ambient temperature. By sequencing the 16S rRNA gene of 270 isolates, fifteen different bacterial families were identified, with both the aerosols and sediments dominated by the Bacillaceae family. Four sets of Rep-PCR primers were tested, with the ERIC and (GTG)5 primers proving to be the most suitable for fingerprinting the cultured taxa. Rep-PCR revealed very high strain diversity in the samples collected, however some strains were still able to be tracked from sediments up to 150 m in height. This shows the potential of Rep-PCR, however very large reference databases would be required for the technique to be more useful. Copyright © 2013 Elsevier B.V. All rights reserved.

Construction d’un outil pour évaluer le degré d’intégration des TIC dans l’enseignement

Directory of Open Access Journals (Sweden)

Pierre-François Coen

2006-01-01

Full Text Available Après un bref survol des enjeux liés à l’intégration des TIC dans l’enseignement, cet article présente le processus de construction d’un instrument (les Vignettes de situation pour l’intégration des TIC ou Visi-TIC destiné à évaluer le degré d’intégration des TIC dans l’enseignement. Il présente les différentes étapes d’élaboration et de validation de cet outil. Proposé en deux variantes (française/allemande pour des élèves âgés de 6 à 7 ans jusqu’à 18 ans, ce nouvel outil s’appuie sur le modèle systémique de l’innovation de Depover et Strebelle (1997, et présente l’avantage d’envisager l’intégration des TIC dans une dynamique de changement.

Rep-PCR typing of Staphylococcus spp. strains in meat paste production line and identification of their origin

Directory of Open Access Journals (Sweden)

Ivan Manga

2015-05-01

Full Text Available A meat paste production line and its microbial parameters have been evaluated in single Czech company. The raw meat paste samples before heat treatment were tested positively for the presence of three staphylococci species: Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus epidermidis. Subsequent microbial analysis of meat paste components and ingredients (fresh meat, water, spices, equipment identified only the spices used as positive for S. aureus (coriander, cinnamon, badian, mustard – (10 - 40 cfu/g and S. haemolyticus strains (juniper, ginger. The collection of sixteen collected strains (S. aureus (n = 4, S. haemolyticus (n = 4, S. epidermidis (n = 8 has been typed with the rep-PCR method utilising (GTG5 primer. Analysis of the fingerprints using the unweighted pair-group method using arithmetic averages (UPGMA clustering method revealed presence of eleven strain clusters with similarity lower than 90%: two fingerprint clusters of S. aureus, three individual clusters characteristic for S. haemolyticus and six different S. epidermidis specific clusters. The S. aureus strains from different types of spice were identical, resp. very similar. Molecular tracking composed from the rep-PCR analysis of acquired isolates and comparison among all collected fingerprints confirmed the spices to be the source of both S. aureus and S. haemolyticus strains identified in raw meat paste. The additional rep-PCR analysis of the S. epidermidis collection confirmed usability and performance of this method. The antibiotic susceptibility to fourteen individual antibiotics has been examined among the collected staphylococci strains. The predominant erythromycin resistance (68.8% was followed with the resistance to amoxicillin/clavulanic acid (56.2%. Other resistances observed were less frequent (clindamycin – 12.5%, oxacillin – 6.3%, tetracycline – 6.3%, sulphamethoxazole-trimethoprim – 6.3%, chloramphenicol – 6.3%, novobiocin – 6

MetaRep, an extended CMAS 3D program to visualize mafic (CMAS, ACF-S, ACF-N) and pelitic (AFM-K, AFM-S, AKF-S) projections

Science.gov (United States)

France, Lydéric; Nicollet, Christian

2010-06-01

MetaRep is a program based on our earlier program CMAS 3D. It is developed in MATLAB ® script. MetaRep objectives are to visualize and project major element compositions of mafic and pelitic rocks and their minerals in the pseudo-quaternary projections of the ACF-S, ACF-N, CMAS, AFM-K, AFM-S and AKF-S systems. These six systems are commonly used to describe metamorphic mineral assemblages and magmatic evolutions. Each system, made of four apices, can be represented in a tetrahedron that can be visualized in three dimensions with MetaRep; the four tetrahedron apices represent oxides or combination of oxides that define the composition of the projected rock or mineral. The three-dimensional representation allows one to obtain a better understanding of the topology of the relationships between the rocks and minerals and relations. From these systems, MetaRep can also project data in ternary plots (for example, the ACF, AFM and AKF ternary projections can be generated). A functional interface makes it easy to use and does not require any knowledge of MATLAB ® programming. To facilitate the use, MetaRep loads, from the main interface, data compiled in a Microsoft Excel ™ spreadsheet. Although useful for scientific research, the program is also a powerful tool for teaching. We propose an application example that, by using two combined systems (ACF-S and ACF-N), provides strong confirmation in the petrological interpretation.

Impacto de la inmigración haitiana sobre el mercado laboral y las finanzas públicas de la República Dominicana

OpenAIRE

Aristy-Escuder, Jaime

2010-01-01

La pobreza del pueblo haitiano influye de forma determinante sobre los flujos migratorios hacia la República Dominicana. Este artículo se propone estimar el impacto de la inmigración haitiana sobre el mercado laboral dominicano, así como sobre sus finanzas públicas. Luego de un exhaustivo análisis teórico y aplicado, el artículo concluye que la mano de obra haitiana es complementaria al capital y a la mano de obra calificada de la República Dominicana. En cambio, es sustituta d...

Méthode intégro-variationnelle appliquée aux probèmes intérieur et extérieur avec surface libre de l'hydrodynamique linéaire Integro-Variational Method Applied to Indoor and Outdoor Problems with a Free Surface of Linear Hydrodinamics

Directory of Open Access Journals (Sweden)

Berhault C.

2006-11-01

Full Text Available Le but de cet article est de montrer que l'on peut appliquer une rintégro-variationnelle pour résoudre les problèmes intérieur (comportementliquide en milieu confiné et extérieur (diffraction-radiation de l'hydrodynamique linéaire. Une comparaison des résultats obtenus pour le problème intérieur dans Q les méthodes classiques : équation intégrale (singularités et formulation rationnelle (éléments finis, montre les avantages de cette méthode. The aim of this article is to show that an integro-variational method can be applied for solving interior (behavior of a liquid in a confined environment and exterior (diffraction-radiation problems of linear hydrodynamics. A comparison of the results obtained for the interior problem in IR2 with conventional methods, i.e. intégral équation (singularities and variational formulation (finite elements, shows the advantages of this method.

La República de los historiadores del Paraguay posbélico

OpenAIRE

Telesca, Ignacio

2015-01-01

En ocasión del bicentenario de la adopción de la República como sistema de gobierno, e independiente tanto de España como de Buenos Aires, este artículo reflexiona sobre como los historiadores paraguayos de fines de siglo XIX reflexionaron sobre el tema, relacionándolo con la adopción de un nuevo sistema de gobierno con la constitución de 1870 (calco de la argentina). Fil: Telesca, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET ...

Intégrer les Tice à une approche cognitive de la grammaire du discours How to integrate ICT into a cognitive approach of a discourse grammar?

Directory of Open Access Journals (Sweden)

Muriel Barbazan

2011-09-01

Full Text Available Si l'on a pour objectif de favoriser un apprentissage de la grammaire évaluable à l'aune des performances communicatives réelles des apprenants, il est utile d'identifier préalablement un cadre de travail qui respecte les processus cognitifs de production et de compréhension. Dans ce cadre, cet article envisage la question de la reformulation des contenus grammaticaux pour cibler l'apprentissage guidé de la langue telle qu'elle est mise en œuvre dans le "discours". Pour ce faire, on illustrera l'intérêt d'une démarche descriptive associant les deux pistes suivantes : a intégrer à la description grammaticale des prototypes de situations d'interactions verbales en relation avec les significations données aux outils grammaticaux. Parallèlement, b mettre en relation les fonctions des outils grammaticaux avec des types de plans textuels tout en insistant sur leur rôle de marqueurs de la macrostructure (repérage des unités textuelles. L'objet de cet article sera ensuite d'explorer les possibilités qu'offrent les Tice pour un apprentissage guidé ciblant l'acquisition de routines grammaticales adaptées à la production / réception du discours en situation. L'accent sera mis sur les activités de compréhension et de réorganisation unifiée des connaissances et savoir-faire grammaticaux, tout en soulignant l'intérêt des Tice pour favoriser en FLE la mise en œuvre effective et interactive de la L2. À partir d'exemples d'activités ou de possibilités d'exploitation de divers outils, cette seconde partie servira ainsi d'illustration aux axes descriptifs et aux orientations didactiques préalablement définis.In the light of results from psycholinguistics and cognitive psychology concerning learning models and verbal production processes, this article follows up two objectives. Before exploring the potential development of grammatical activities in a digital learning environment, the first part will explore how we can conceive

Protección contra la violencia sexual en la República Democrática del Congo

OpenAIRE

Mosely, Sarah; Cetinoglu, Talita; Glad, Marit

2010-01-01

Si bien la prestación de servicios a los supervivientes de la violencia sexual es la principal prioridad en la República Democrática del Congo, la protección para las mujeres y niñas también puede mejorarse.

75 FR 78694 - Proposed Residential Exchange Program Settlement Agreement Proceeding (REP-12); Public Hearing...

Science.gov (United States)

2010-12-16

..., 2010, on BPA's Web site at http://www.bpa.gov/corporate/ratecase/2012/rep-12.cfm . Hard copies of these.... Bonneville Power Admin., 928 F.2d 905 (9th Cir. 1991). Due to the burdensome, expensive and contentious... Electric v. Bonneville Power Admin., 501 F.3d 1009 (9th Cir. 2007) (PGE), the Court found that BPA had...

El Museo de Arte del Banco de la República

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Boletín Cultural y Bibliográfico Banco de la República

2003-05-01

Full Text Available El Banco de la República desde sus comienzos, en los años veinte y treinta del siglo pasado, ha apoyado la cultura. De esas épocas datan los inicios de las colecciones de numismática y orfebrería, creadas con la intención de preservar y defender el patrimonio artístico y cultural colombiano. A ese atesoramiento se une el desarrollo de otras colecciones que son referencia obligada para el conocimiento de la historia de Colombia: la colección documental (bibliográfica, hemerográfica, audiovisual, la de arte, a partir de 1957 y la de filatelia.

Liberalismo, iluminismo y romanticismo: el problema de la libertad en dos novelas de la República Restaurada

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Verónica Hernández Landa Valencia

2016-07-01

Full Text Available El artículo propone una reflexión en torno a la forma como influyen tres corrientes de pensamiento, el liberalismo, el iluminismo y el romanticismo, en la representación del problema de la libertad en dos novelas históricas publicadas en la República Restaurada: Monja y casada, virgen y mártir, de Vicente Riva Palacio, y El pecado del siglo, de José Tomás de Cuéllar. Se busca mostrar que dichas corrientes se entrecruzan en un solo texto, que ello contribuye a la conformación de un concepto de libertad restringida y que la forma específica que adquiere ese concepto se explica a partir de la postura ideológica y política de los autores en el contexto de la República Restaurada.

Variation in extragenic repetitive DNA sequences in Pseudomonas syringae and potential use of modified REP primers in the identification of closely related isolates

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Elif Çepni

2012-01-01

Full Text Available In this study, Pseudomonas syringe pathovars isolated from olive, tomato and bean were identified by species-specific PCR and their genetic diversity was assessed by repetitive extragenic palindromic (REP-PCR. Reverse universal primers for REP-PCR were designed by using the bases of A, T, G or C at the positions of 1, 4 and 11 to identify additional polymorphism in the banding patterns. Binding of the primers to different annealing sites in the genome revealed additional fingerprint patterns in eight isolates of P. savastanoi pv. savastanoi and two isolates of P. syringae pv. tomato. The use of four different bases in the primer sequences did not affect the PCR reproducibility and was very efficient in revealing intra-pathovar diversity, particularly in P. savastanoi pv. savastanoi. At the pathovar level, the primer BOX1AR yielded shared fragments, in addition to five bands that discriminated among the pathovars P. syringae pv. phaseolicola, P. savastanoi pv. savastanoi and P. syringae pv. tomato. REP-PCR with a modified primer containing C produced identical bands among the isolates in a pathovar but separated three pathovars more distinctly than four other primers. Although REP-and BOX-PCRs have been successfully used in the molecular identification of Pseudomonas isolates from Turkish flora, a PCR based on inter-enterobacterial repetitive intergenic concensus (ERIC sequences failed to produce clear banding patterns in this study.

Comparison of semi-automated commercial rep-PCR fingerprinting, spoligotyping, 12-locus MIRU-VNTR typing and single nucleotide polymorphism analysis of the embB gene as molecular typing tools for Mycobacterium bovis.

Science.gov (United States)

Armas, Federica; Camperio, Cristina; Coltella, Luana; Selvaggini, Serena; Boniotti, Maria Beatrice; Pacciarini, Maria Lodovica; Di Marco Lo Presti, Vincenzo; Marianelli, Cinzia

2017-08-04

Highly discriminatory genotyping strategies are essential in molecular epidemiological studies of tuberculosis. In this study we evaluated, for the first time, the efficacy of the repetitive sequence-based PCR (rep-PCR) DiversiLab Mycobacterium typing kit over spoligotyping, 12-locus mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) typing and embB single nucleotide polymorphism (SNP) analysis for Mycobacterium bovis typing. A total of 49 M. bovis animal isolates were used. DNA was extracted and genomic DNA was amplified using the DiversiLab Mycobacterium typing kit. The amplified fragments were separated and detected using a microfluidics chip with Agilent 2100. The resulting rep-PCR-based DNA fingerprints were uploaded to and analysed using web-based DiversiLab software through Pearson's correlation coefficient. Rep-PCR DiversiLab grouped M. bovis isolates into ten different clusters. Most isolates sharing identical spoligotype, MIRU-VNTR profile or embB gene polymorphism were grouped into different rep-PCR clusters. Rep-PCR DiversiLab displayed greater discriminatory power than spoligotyping and embB SNP analysis but a lower resolution power than the 12-locus MIRU-VNTR analysis. MIRU-VNTR confirmed that it is superior to the other PCR-based methods tested here. In combination with spoligotyping and 12-locus MIRU-VNTR analysis, rep-PCR improved the discriminatory power for M. bovis typing.

IntCal04 terrestrial radiocarbon age calibration, 0-26 cal kyr BP

NARCIS (Netherlands)

Reimer, Paula J.; Baillie, Mike G.L.; Bard, Edouard; Bayliss, Alex; Beck, J. Warren; Bertrand, Chanda J.H.; Blackwell, Paul G.; Buck, Caitlin E.; Burr, George S.; Cutler, Kirsten B.; Damon, Paul E.; Edwards, R. Lawrence; Fairbanks, Richard G.; Friedrich, Michael; Guilderson, Thomas P.; Hogg, Alan G.; Hughen, Konrad A.; Kromer, Bernd; McCormac, Gerry; Manning, Sturt; Bronk Ramsey, Christopher; Reimer, Ron W.; Remmele, Sabine; Southon, John R.; Stuiver, Minze; Talamo, Sahra; Taylor, F.W.; Plicht, Johannes van der; Weyhenmeyer, Constanze E.

2004-01-01

A new calibration curve for the conversion of radiocarbon ages to calibrated (cal) ages has been constructed and internationally ratified to replace IntCal98, which extended from 0–24 cal kyr BP (Before Present, 0 cal BP = AD 1950). The new calibration data set for terrestrial samples extends from

Topology reconstruction for B-Rep modeling from 3D mesh in reverse engineering applications

Science.gov (United States)

Bénière, Roseline; Subsol, Gérard; Gesquière, Gilles; Le Breton, François; Puech, William

2012-03-01

Nowadays, most of the manufactured objects are designed using CAD (Computer-Aided Design) software. Nevertheless, for visualization, data exchange or manufacturing applications, the geometric model has to be discretized into a 3D mesh composed of a finite number of vertices and edges. But, in some cases, the initial model may be lost or unavailable. In other cases, the 3D discrete representation may be modified, for example after a numerical simulation, and does not correspond anymore to the initial model. A reverse engineering method is then required to reconstruct a 3D continuous representation from the discrete one. In previous work, we have presented a new approach for 3D geometric primitive extraction. In this paper, to complete our automatic and comprehensive reverse engineering process, we propose a method to construct the topology of the retrieved object. To reconstruct a B-Rep model, a new formalism is now introduced to define the adjacency relations. Then a new process is used to construct the boundaries of the object. The whole process is tested on 3D industrial meshes and bring a solution to recover B-Rep models.

Partial enthalpies of Bi and Te in Bi-Te melts and of In and Te in In-Te melts

International Nuclear Information System (INIS)

Yassin, Abeer; Amzil, Abdelhamid; Castanet, Robert

2000-01-01

Full text.Calorimetric measurement are reported which allow the enthalpic behaviour of Bi-Te melts to be established. Further work is required, however, to supplement results obtained for In-Te melts. The partial enthalpies of bismuth and tellurium in the Bi-Te melts at 755K and those of indium and tellurium in the In-Te melts at 1010 and 987K were measured at high dilution by direct reaction calorimetry (drop method) with the help of a Tian-Calvet calorimeter. The limiting partial enthalpies of the components were deduced by extrapolation at infinite dilution: Δh f,∞ B i(755K)/KJ.mol -1 = -34.0 and Δh f,∞ Te(755K) /KJ·mol -1 = -24.1 in the Bi-Te melts Δh f,∞ In(1010K) /KJ·mol -1 = -75.9 and Δh f,∞ Te(1010K) /KJ·mol -1 = -47.8 in the In-Te melts Δh f,∞ In(987K) /KJ·mol -1 = -75.2 and Δh f,∞ Te(987K) /KJ·mol -1 = -48.0 in the In-Te melts

c Intes compo on die stine h osition ets wit istolog of Nile th both gy ...

African Journals Online (AJOL)

SAM

plicates. Fish estigated. Tr had six rep ermined. Th hey were s the most e tein was e .... recommends the use of up to 20% sunflower in the diet of ... to improve the quality of feed. .... Trial 1 was run for a period of 120 days in a pond with a water.

Campylobacter jejuni induces diverse kinetics and profiles of cytokine genes in INT-407 cells

International Nuclear Information System (INIS)

Al-Amri, Ahlam I.; Bakhiet, Moiz O.; Botta, Giuseppe A.; Tabbara, Khaled S.; Ismaeel, Abdelrahman Y.; Al-Mahmeed, Ali E.; Bin Danya, Khalid M.

2008-01-01

Objective was to examine the kinetic ability of embryonic human epithelial INT-407 cells to express messenger ribonucleic acid (mRNA) for various cytokines and chemokines in response to Campylobacter jejuni (C. jejuni) stimulation. In an experimental single-blind study, cultured embryonic human epithelial INT-407 cells were treated with different concentrations of viable C. jejuni, its sonicated and filtered supernatant. A modified non-radioactive in situ hybridization using probe cocktails was used to measure mRNA levels for the pro-inflammatory cytokines interleukin (IL)-1beta, IL-6, interferon-gamma, tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1 and IL-8 and the anti-inflammatory cytokines, IL-4 and IL-10. The study was carried out from September 2005 to March 2007 at the Department of Microbiology, Immunology and Infectious Diseases, College of Medicine and Medical Sciences, Arabian Gulf University, Bahrain. Viable C. jejuni sonicated bacteria and filtered supernatant induced high mRNA expression for the pro-inflammatory cytokines IL-1 beta, IL-6, IFN-gama, TNF-alpha, TGF-beta and IL-8 which peaked at the 12 hours post stimulation. Anti-inflammatory cytokine IL-4 and IL-10 mNRA expression were induced maximally at 3 hours post stimulation mainly by sonicated bacteria and filtrated supernatant, however, not with living bacteria and filtrated supernatant, however, not with living bacteria. Untreated embryonic human epithelial INT-407 cells expressed low amount of mNRA for the various cytokines and chemokines at all time points. For each cytokine, 4 samples were used per time hour. This study demonstrated that embryonic human epithelial INT-407 cells in response to viable C. jejuni or its cytotxins can alter cytokine and chemokine mNRA expression patterns and kinetics suggesting a potential role for these mediators in the immunopathogenesis of the infection caused by this pathogen, which might be relevant for future immunotherapeutic

Repše: välislaenuabi katkedes on aasta lõpuks raha läbi / Mikk Salu

Index Scriptorium Estoniae

Salu, Mikk, 1975-

2009-01-01

Läti rahandusminister Einars Repše hoiatas, et kui Lätil ei õnnestu täita oma kohustusi rahvusvaheliste kreeditoride ees ja vähendada 2010. a. eelarvedefitsiiti poole miljardi lati võrra, võib riigikassa rahast tühjaks joosta juba enne aasta lõppu

Hacia una república conservadora : el programa político del Partido Agrario Español

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Luis Teófilo Gil Cuadrado

2005-01-01

Full Text Available El Partido Agrario Español (PAE, fundado en enero de 1934 y presidido por José Martínez de Velasco, representó, dentro de la II República española, una alternativa conservadora y, al tiempo, leal al régimen. El programa político del PAE aceptaba la República —a diferencia de otros partidos derechistas del momento, como la CEDA y los monárquicos— y defendía la unidad nacional, el establecimiento de una segunda Cámara legislativa, la protección de la agricultura y la industria mediante aranceles, el libre comercio dentro de las fronteras nacionales y la revisión de algunas leyes del primer bienio como la Reforma Agraria de 1932. El objetivo era la configuración de una República conservadora distinta, en aspectos fundamentales, a la diseñada por la Constitución de 1931 y la legislación del bienio social-republicano.The Spanish Agrarian Party (Partido Agrario Español, PAE, founded in january of 1934 and presided by José Martínez de Velasco, was, in the political life of the Spanish Second Republic, a conservative and republican option. The agrarian program accepted the republican regime —in opposition to other conservative parties, like the CEDA or the monarchists— and defended the national union, the establishment of a Senate, the protection of the national agriculture and industry trough tariffs, the free trade in the Spanish market and the revision of some laws voted in the first biennium like the Agrarian Reform, promulgated in 1932. The idea was to establish a conservative Republic, different, in some fundamental aspects, of the regime designed by the Constitution of 1931 and the legislation approved during the socialist-republican biennium.

Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and Cap.

Science.gov (United States)

Conway, J E; Zolotukhin, S; Muzyczka, N; Hayward, G S; Byrne, B J

1997-11-01

Recombinant adeno-associated virus (AAV) type 2 (rAAV) vectors have recently been shown to have great utility as gene transfer agents both in vitro and in vivo. One of the problems associated with the use of rAAV vectors has been the difficulty of large-scale vector production. Low-efficiency plasmid transfection of the rAAV vector and complementing AAV type 2 (AAV-2) functions (rep and cap) followed by superinfection with adenovirus has been the standard approach to rAAV production. The objectives of this study were to demonstrate the ability of a recombinant herpes simplex virus type 1 (HSV-1) amplicon expressing AAV-2 Rep and Cap to support replication and packaging of rAAV vectors. HSV-1 amplicon vectors were constructed which contain the AAV-2 rep and cap genes under control of their native promoters (p5, p19, and p40). An HSV-1 amplicon vector, HSV-RC/KOS or HSV-RC/d27, was generated by supplying helper functions with either wild-type HSV-1 (KOS strain) or the ICP27-deleted mutant of HSV-1, d27-1, respectively. Replication of the amplicon stocks is not inhibited by the presence of AAV-2 Rep proteins, which highlights important differences between HSV-1 and adenovirus replication and the mechanism of providing helper function for productive AAV infection. Coinfection of rAAV and HSV-RC/KOS resulted in the replication and amplification of rAAV genomes. Similarly, rescue and replication of rAAV genomes occurred when rAAV vector plasmids were transfected into cells followed by HSV-RC/KOS infection and when two rAAV proviral cell lines were infected with HSV-RC/KOS or HSV-RC/d27. Production of infectious rAAV by rescue from two rAAV proviral cell lines has also been achieved with HSV-RC/KOS and HSV-RC/d27. The particle titer of rAAV produced with HSV-RC/d27 is equal to that achieved by supplying rep and cap by transfection followed by adenovirus superinfection. Importantly, no detectable wild-type AAV-2 is generated with this approach. These results demonstrate

Exon sequence requirements for excision in vivo of the bacterial group II intron RmInt1

Directory of Open Access Journals (Sweden)

Toro Nicolás

2011-05-01

Full Text Available Abstract Background Group II intron splicing proceeds through two sequential transesterification reactions in which the 5' and 3'-exons are joined together and the lariat intron is released. The intron-encoded protein (IEP assists the splicing of the intron in vivo and remains bound to the excised intron lariat RNA in a ribonucleoprotein particle (RNP that promotes intron mobility. Exon recognition occurs through base-pairing interactions between two guide sequences on the ribozyme domain dI known as EBS1 and EBS2 and two stretches of sequence known as IBS1 and IBS2 on the 5' exon, whereas the 3' exon is recognized through interaction with the sequence immediately upstream from EBS1 [(δ-δ' interaction (subgroup IIA] or with a nucleotide [(EBS3-IBS3 interaction (subgroup IIB and IIC] located in the coordination-loop of dI. The δ nucleotide is involved in base pairing with another intron residue (δ' in subgroup IIB introns and this interaction facilitates base pairing between the 5' exon and the intron. Results In this study, we investigated nucleotide requirements in the distal 5'- and 3' exon regions, EBS-IBS interactions and δ-δ' pairing for excision of the group IIB intron RmInt1 in vivo. We found that the EBS1-IBS1 interaction was required and sufficient for RmInt1 excision. In addition, we provide evidence for the occurrence of canonical δ-δ' pairing and its importance for the intron excision in vivo. Conclusions The excision in vivo of the RmInt1 intron is a favored process, with very few constraints for sequence recognition in both the 5' and 3'-exons. Our results contribute to understand how group II introns spread in nature, and might facilitate the use of RmInt1 in gene targeting.

Direct Application of Rep-PCR on Type I Sourdough Matrix to Monitor the Dominance and Persistence of a Lactobacillus plantarum Starter Throughout Back-Slopping.

Science.gov (United States)

Dolci, Paola; Cocolin, Luca

2017-08-01

This study describes the optimization and application of repetitive element-PCR (rep-PCR) technique directly on microbial DNA extracted from type I sourdoughs for fast monitoring of a Lb. plantarum starter strain (P1FMC) throughout daily back-slopping. The challenge was to follow and study the performance of a starter culture directly in sourdoughs without cultivation on selective media. The extraction of good quality microbial DNA suitable for amplification from a complex matrix such as dough was the first target. In addition, the objective to obtain a clear rep-PCR profile referable to a specific starter strain among a microbial community was pursued. Co-inoculum trials, in flour matrix, with Lb. plantarum P1FMC and L. lactis LC71 strains and, subsequently, type I sourdough back-slopping trials were performed. The rep-PCR amplification profiles obtained were clearly referable to that of Lb. plantarum P1FMC starter in both co-inoculum trials (also when it was present with one order of magnitude less with respect to L. lactis LC71) and back-slopping trials where it dominated the fermentation process with loads of 10 8 cfu g -1 and prevailed on the autochthonous microbiota. Thus, the approach proposed in this paper could be considered a methodological advancement, based on a culture-independent one-step rep-PCR, suitable for fast monitoring of starter performance. © 2017 Institute of Food Technologists®.

¿Por qué no la Segunda República Argentina?

Directory of Open Access Journals (Sweden)

Manuel ALCÁNTARA SÁEZ

2009-11-01

Full Text Available RESUMEN: El autor analiza en este artículo el proceso de Reforma Constitucional que se está desarrollando en Argentina. Teniendo en cuenta la coyuntura actual del régimen político, el desarollo de este proceso de reforma y los cambios previstos que van a resultar de esta «Refundación de la República» el autor apunta las posibilidades y problemas que estos datos permiten vislumbrar.ABSTRACT: In this article, the author analyzes the present process of Constitutional Reform in Argentina. Studying the current moment of argentinian political regime, the development of this reform process and possible changes of this «Republic Refoundation» the author points out the possibilities and problems that this information indicates.

La Segunda República, una coyuntura para las mujeres españolas: Cambios y permanencias en las relaciones de género.

OpenAIRE

Merino Hernández, Rosa María

2016-01-01

[ES] En España, no será hasta el período de la Segunda República (1931-1939), cuando las mujeres conseguirán el reconocimiento de ciudadanas de pleno derecho en igualdad con los hombres, respaldadas por la Constitución de 1931. La Segunda República española da voz y derechos a más de la otra mitad de la población del país, por lo que la convierte en una época única, en una etapa nueva donde convivirán el cambio y la permanencia, el avance hacia una nueva sociedad y, dentro de ésta, la emer...

La ansiedad escénica en intérpretes musicales chilenos

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Mimí Marinovic

2006-06-01

Full Text Available La ansiedad escénica (AE es uno de los mayores problemas del ejercicio profesional de los intérpretes musicales. Encuestas realizadas en países desarrollados revelan cifras de prevalencia entre 24% -70% y citan casos severos, causantes del abandono de la carrera. Objetivos: detectar la prevalencia de la AE en músicos chilenos que desempeñan su profesión en los principales conjuntos de música de concierto y determinar algunos de los factores que, a su juicio, influyen en su aparición. Método: 249 intérpretes (122 instrumentistas, 26 directores y 101 cantantes respondieron un cuestionario autoaplicado, incluido en una investigación más amplia sobre los intérpretes de arte. Este instrumento fue complementado con 36 entrevistas abiertas (13 instrumentistas, 6 directores y 11 cantantes. Resultados: el 78% de los músicos estudiados admitió haber sufrido AE, más mujeres que varones. El 64% consideró que ella se relaciona principalmente con la tarea a ejecutar (preparación insuficiente, dificultad de la obra, mientras que el 32% lo atribuyó a factores personales (ser nervioso, temor al fracaso y sólo el 4% a factores situacionales. Hubo diferencias significativas por género, especialidad y edad. Las entrevistas permitieron profundizar acerca del alcance de estos resultados. Conclusiones: se constató una alta prevalencia de AE, la cual debiera ser abordada interdisciplinariamente por especialistas de la salud mental y la música en beneficio de la educación general, la formación especializada y el desarrollo profesional de los intérpretes musicalesPerformance anxiety (PA is one of the major problems that musicians face in their careers. Surveys carried out in developed countries show prevalence figures ranging 24% -70% and quote severe cases leading to abandonment of the profession. Objectives: detect the prevalence of PA in Chilean musicians working in the main groups of concert music and determine some of the factors that

Evolución y relevancia del turismo en la República Dominicana

OpenAIRE

Real Aquino, Héctor Julio

2014-01-01

República Dominicana es un país que durante las últimas décadas ha sufrido grandes transformaciones socioeconómicas, anteriormente su economía dependía casi exclusivamente de la elaboración y exportación de productos agrícolas como: la caña de azúcar, cacao, tabaco, y en menor medida, la industria textil. Ese panorama se ha modificado, debido en gran parte al turismo, dado que este subsector de la economía se ha convertido en la principal actividad económica del país. La evolución y relevanci...

A method and software for segmentation of anatomic object ensembles by deformable m-reps

International Nuclear Information System (INIS)

Pizer, Stephen M.; Fletcher, P. Thomas; Joshi, Sarang; Gash, A. Graham; Stough, Joshua; Thall, Andrew; Tracton, Gregg; Chaney, Edward L.

2005-01-01

Deformable shape models (DSMs) comprise a general approach that shows great promise for automatic image segmentation. Published studies by others and our own research results strongly suggest that segmentation of a normal or near-normal object from 3D medical images will be most successful when the DSM approach uses (1) knowledge of the geometry of not only the target anatomic object but also the ensemble of objects providing context for the target object and (2) knowledge of the image intensities to be expected relative to the geometry of the target and contextual objects. The segmentation will be most efficient when the deformation operates at multiple object-related scales and uses deformations that include not just local translations but the biologically important transformations of bending and twisting, i.e., local rotation, and local magnification. In computer vision an important class of DSM methods uses explicit geometric models in a Bayesian statistical framework to provide a priori information used in posterior optimization to match the DSM against a target image. In this approach a DSM of the object to be segmented is placed in the target image data and undergoes a series of rigid and nonrigid transformations that deform the model to closely match the target object. The deformation process is driven by optimizing an objective function that has terms for the geometric typicality and model-to-image match for each instance of the deformed model. The success of this approach depends strongly on the object representation, i.e., the structural details and parameter set for the DSM, which in turn determines the analytic form of the objective function. This paper describes a form of DSM called m-reps that has or allows these properties, and a method of segmentation consisting of large to small scale posterior optimization of m-reps. Segmentation by deformable m-reps, together with the appropriate data representations, visualizations, and user interface, has been

Programme intégré de lutte contre le paludisme en Afrique ...

International Development Research Centre (IDRC) Digital Library (Canada)

Le paludisme demeure le plus grand facteur de morbidité et de mortalité dans ... sur le système de santé (diagnostic, gestion et prévention des cas), de mesures ... la recherche visant à comprendre la dynamique sociétale et environnementale ... Rapport technique final Écosanté / le contrôle intégré du paludisme basé sur ...

Realidades de la independencia del Banco de la República Realities of the independence of the Banco de la República

Directory of Open Access Journals (Sweden)

Kalmanovitz Salomón

1997-12-01

Full Text Available La autonomía del banco central Colombiano es parte del proceso político que buscaba reducir el exagerado centralismo colombiano. Sin embargo el poder central no fue limitado en grado suficiente por la Constitución del 1991, como muestra el hecho de que el Ministro de Hacienda es el Presidente de la Junta Directiva del Banco de la República. Esto no sucede en ningun banco independiente del mundo por que los objetivos del gobierno son distintos a los del Banco Central y el Ministerio de Finanzas podría desviar al Banco de sus objetivos antiinflacionarios fundamentales. En Colombia, el gobierno no sólo participa en la Junta para acomodar sus múltiples objetivos sino también hace opocisión pública a la política monetaria y así la desacredita. El articulo plantea que el principio de no reelección hace que el horizonte de tiempo sea muy corto para que el gobierno coseche los frutos de una política de estabilización. El gobierno tiende a gastar en exceso para mejorar su imagen pública y el desajuste lo tiene que enfrentar el gobierno siguiente. De modo que la coordinación entre el Banco Central y el gobierno se torna muy conflictiva.The autonomy of the Central Bank of Colombia is part of a political process which seeks to reduce Colombia' s exaggerated centralismo However, central power was not limited to a sufficient degree by the Constitution of 1991, as demonstrated by the fact that the Minister of Finance is the President of the Board of Directors of the Banco de la República. This does not happen in any independent bank in the world, because the objectives of the government are different from those of the central bank, and the Minister of Finance could divert the Bank away from its fundamental anti-inflationary objectives. This article proposes that the principle of no reelection makes the time horizon very short for the government to reap the fruits of a stabilization policy. The government tends to spend in excess in order to

Analysis of a new strain of Euphorbia mosaic virus with distinct replication specificity unveils a lineage of begomoviruses with short Rep sequences in the DNA-B intergenic region

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Argüello-Astorga Gerardo R

2010-10-01

Full Text Available Abstract Background Euphorbia mosaic virus (EuMV is a member of the SLCV clade, a lineage of New World begomoviruses that display distinctive features in their replication-associated protein (Rep and virion-strand replication origin. The first entirely characterized EuMV isolate is native from Yucatan Peninsula, Mexico; subsequently, EuMV was detected in weeds and pepper plants from another region of Mexico, and partial DNA-A sequences revealed significant differences in their putative replication specificity determinants with respect to EuMV-YP. This study was aimed to investigate the replication compatibility between two EuMV isolates from the same country. Results A new isolate of EuMV was obtained from pepper plants collected at Jalisco, Mexico. Full-length clones of both genomic components of EuMV-Jal were biolistically inoculated into plants of three different species, which developed symptoms indistinguishable from those induced by EuMV-YP. Pseudorecombination experiments with EuMV-Jal and EuMV-YP genomic components demonstrated that these viruses do not form infectious reassortants in Nicotiana benthamiana, presumably because of Rep-iteron incompatibility. Sequence analysis of the EuMV-Jal DNA-B intergenic region (IR led to the unexpected discovery of a 35-nt-long sequence that is identical to a segment of the rep gene in the cognate viral DNA-A. Similar short rep sequences ranging from 35- to 51-nt in length were identified in all EuMV isolates and in three distinct viruses from South America related to EuMV. These short rep sequences in the DNA-B IR are positioned downstream to a ~160-nt non-coding domain highly similar to the CP promoter of begomoviruses belonging to the SLCV clade. Conclusions EuMV strains are not compatible in replication, indicating that this begomovirus species probably is not a replicating lineage in nature. The genomic analysis of EuMV-Jal led to the discovery of a subgroup of SLCV clade viruses that contain in

repDNA: a Python package to generate various modes of feature vectors for DNA sequences by incorporating user-defined physicochemical properties and sequence-order effects.

Science.gov (United States)

Liu, Bin; Liu, Fule; Fang, Longyun; Wang, Xiaolong; Chou, Kuo-Chen

2015-04-15

In order to develop powerful computational predictors for identifying the biological features or attributes of DNAs, one of the most challenging problems is to find a suitable approach to effectively represent the DNA sequences. To facilitate the studies of DNAs and nucleotides, we developed a Python package called representations of DNAs (repDNA) for generating the widely used features reflecting the physicochemical properties and sequence-order effects of DNAs and nucleotides. There are three feature groups composed of 15 features. The first group calculates three nucleic acid composition features describing the local sequence information by means of kmers; the second group calculates six autocorrelation features describing the level of correlation between two oligonucleotides along a DNA sequence in terms of their specific physicochemical properties; the third group calculates six pseudo nucleotide composition features, which can be used to represent a DNA sequence with a discrete model or vector yet still keep considerable sequence-order information via the physicochemical properties of its constituent oligonucleotides. In addition, these features can be easily calculated based on both the built-in and user-defined properties via using repDNA. The repDNA Python package is freely accessible to the public at http://bioinformatics.hitsz.edu.cn/repDNA/. bliu@insun.hit.edu.cn or kcchou@gordonlifescience.org Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

La función administrativa ejercida por el Congreso de la República

OpenAIRE

Ortiz, Maribel

2017-01-01

La función administrativa en Colombia, no sólo es desarrollada por la Rama Ejecutiva del poder público, sino que también es ejercida por la Rama Legislativa para el cumplimiento de sus fines. Es a partir de la Constitución de 1991, cuando en desarrollo del mandato Constitucional y de las facultades que tiene el Congreso de la República, se expidieron dos normativas: la ley 3ª de 1992 (por la cual se expiden normas sobre las Comisiones del Congreso de Colombia y se dictan otras disposici...

La radio en la segunda república española: sociedad y publicidad

OpenAIRE

Sebastián Morillas, Sebastián

2006-01-01

El artículo versa sobre la evolución del medio radio durante la II República Española a la vez que analiza la publicidad radiofónica de la época y sus efectos en una sociedad a punto de dividirse en dos bandos enfrentados en armas. This article is about the evolution of the radio broadcast during the Second Spanish Republic. It also analyses the radio commercials in that time, and how this commercials had a great influence on Spanish society, which was close to a civil war.

L'intégration des plantes médicinales en Inde | IDRC - International ...

International Development Research Centre (IDRC) Digital Library (Canada)

3 févr. 2011 ... Un nouveau programme lancé par le gouvernement de l'Inde pour intégrer les plantes médicinales aux pratiques médicales traditionnelles et aux moyens de subsistance habituels pourrait être une source de revenus pour les villageois qui en font la cueillette et rendre leur utilisation plus sécuritaire.

MetrIntSimil—An Accurate and Robust Metric for Comparison of Similarity in Intelligence of Any Number of Cooperative Multiagent Systems

Directory of Open Access Journals (Sweden)

Laszlo Barna Iantovics

2018-02-01

Full Text Available Intelligent cooperative multiagent systems are applied for solving a large range of real-life problems, including in domains like biology and healthcare. There are very few metrics able to make an effective measure of the machine intelligence quotient. The most important drawbacks of the designed metrics presented in the scientific literature consist in the limitation in universality, accuracy, and robustness. In this paper, we propose a novel universal metric called MetrIntSimil capable of making an accurate and robust symmetric comparison of the similarity in intelligence of any number of cooperative multiagent systems specialized in difficult problem solving. The universality is an important necessary property based on the large variety of designed intelligent systems. MetrIntSimil makes a comparison by taking into consideration the variability in intelligence in the problem solving of the compared cooperative multiagent systems. It allows a classification of the cooperative multiagent systems based on their similarity in intelligence. A cooperative multiagent system has variability in the problem solving intelligence, and it can manifest lower or higher intelligence in different problem solving tasks. More cooperative multiagent systems with similar intelligence can be included in the same class. For the evaluation of the proposed metric, we conducted a case study for more intelligent cooperative multiagent systems composed of simple computing agents applied for solving the Symmetric Travelling Salesman Problem (STSP that is a class of NP-hard problems. STSP is the problem of finding the shortest Hamiltonian cycle/tour in a weighted undirected graph that does not have loops or multiple edges. The distance between two cities is the same in each opposite direction. Two classes of similar intelligence denoted IntClassA and IntClassB were identified. The experimental results show that the agent belonging to IntClassA intelligence class is less

Feature selection and data sampling methods for learning reputation dimensions: The University of Amsterdam at RepLab 2014

NARCIS (Netherlands)

Gârbacea, C.; Tsagkias, M.; de Rijke, M.

2014-01-01

We report on our participation in the reputation dimension task of the CLEF RepLab 2014 evaluation initiative, i.e., to classify social media updates into eight predefined categories. We address the task by using corpus-based methods to extract textual features from the labeled training data to

Intéresser les jeunes à la chose publique | CRDI - Centre de ...

International Development Research Centre (IDRC) Digital Library (Canada)

22 oct. 2010 ... Les gouvernements ont tout intérêt à faire appel à la solidarité naturelle des jeunes en les consultant et en les amenant à participer aux processus de prise ... Dans un pays comme dans l'autre, cependant, les jeunes votent peu, et ce, en dépit du vote obligatoire au Brésil (au risque d'être mis à l'amende) et ...

Application de la gestion intégrale de l'innovation dans les petites et ...

International Development Research Centre (IDRC) Digital Library (Canada)

'application d'un cadre de gestion intégrale de l'innovation destiné exclusivement aux PME. Les capacités de recherche et de mise en oeuvre seront améliorées au moyen d'une formation aux cycles supérieurs ou d'une autre nature.

La República Holandesa y su posición en el contexto colonial americano después de 1713

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Crespo Solana, Ana

2015-06-01

Full Text Available During the War of Spanish Succession, the Dutch Republic fought alongside the Austrians and their allies against the Bourbon party. Still, and in spite of its alliance with England, the treaties of Utrecht did not leave the Dutch Republic in a good position. In this article, these treaties’ consequences for the commercial and colonial Dutch expansion in the Atlantic world are analyzed.Durante la guerra de Sucesión española, la República Holandesa luchó junto al bloque aliado austracista contra la opción borbónica. Sin embargo, y a pesar de su alianza con Inglaterra, la República Holandesa no salió bien restablecida de los tratados de Utrecht. En este artículo se analizarán las consecuencias que estos tratados tuvieron para la expansión comercial y colonial de Holanda en el Atlántico.

Engineered bacterial hydrophobic oligopeptide repeats in a synthetic yeast prion, [REP-PSI+

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Fátima eGasset-Rosa

2015-04-01

Full Text Available The yeast translation termination factor Sup35p, by aggregating as the [PSI+] prion, enables ribosomes to read-through stop codons, thus expanding the diversity of the Saccharomyces cerevisiae proteome. Yeast prions are functional amyloids that replicate by templating their conformation on native protein molecules, then assembling as large aggregates and fibers. Prions propagate epigenetically from mother to daughter cells by fragmentation of such assemblies. In the N-terminal prion-forming domain, Sup35p has glutamine/asparagine-rich oligopeptide repeats (OPRs, which enable propagation through chaperone-elicited shearing. We have engineered chimeras by replacing the polar OPRs in Sup35p by up to five repeats of a hydrophobic amyloidogenic sequence from the synthetic bacterial prionoid RepA-WH1. The resulting hybrid, [REP-PSI+], i was functional in a stop codon read-through assay in S. cerevisiae; ii generates weak phenotypic variants upon both its expression or transformation into [psi-] cells; iii these variants correlated with high molecular weight aggregates resistant to SDS during electrophoresis; and iv according to fluorescence microscopy, the fusion of the prion domains from the engineered chimeras to the reporter protein mCherry generated perivacuolar aggregate foci in yeast cells. All these are signatures of bona fide yeast prions. As assessed through biophysical approaches, the chimeras assembled as oligomers rather than as the fibers characteristic of [PSI+]. These results suggest that it is the balance between polar and hydrophobic residues in OPRs what determines prion conformational dynamics. In addition, our findings illustrate the feasibility of enabling new propagation traits in yeast prions by engineering OPRs with heterologous amyloidogenic sequence repeats.

La europeización de la República de Moldova: un camino sinuoso e incierto hacia la integración europea

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Aurelia Dercaci

2014-01-01

Full Text Available Después de la proclamación de la independencia en 1991, la República de Moldova (RM ha declarado su firme determinación de emprender su camino hacia Europa, a la que se siente identificada culturalmente. Aunque en las declaraciones y documentos adoptados el Estado nunca ha renunciado a este objetivo, ciertas acciones de sus líderes políticos parecen contradecir dicho compromiso. El trabajo tiene como objetivo analizar el proceso de evolución de la República de Moldova a la Unión Europea (UE, los compromisos asumidos por ambos y su cumplimiento. Además, voy a comparar los progresos realizados por Ucrania y RM hacia el acercamiento a la Unión Europea en los últimos años. Hace algunos años, Ucrania fue el país oriental con la perspectiva fundamental de la futura integración en la UE debido a sus cambios democráticos, hoy República de Moldova ha demostrado ser capaz de hacer más progresos en la promoción de la democracia y la aplicación de las reformas de gobernanza que Ucrania. Por otro lado, la relación entre la RM y la UE sigue siendo influenciada por las medidas adoptadas por la Federación de Rusia en la región donde todavía tiene influencia significativa, y tratar de mantener su presencia. Una de las herramientas fuertes de la influencia es la dependencia del suministro de energía y su falta de diversificación. El conflicto sin resolver de Transnistria es otro factor determinante de la falta de certeza en el proceso de europeización de la RM. El trabajo tiene como objetivo analizar la eficiencia de la europeización de la República de Moldova a través de la Política de Vecindad Europea, utilizando un método combinado constructivista y racionalista.

diversité des pratiques d'intégration agriculture – élevage

African Journals Online (AJOL)

BOL BI

Dans le sud la région de Maradi, l'agriculture et l'élevage sont les deux principales activités socio-économiques qui occupent environ 95% de la population. Ces activités sont pratiquées de façon intégrée dans un contexte de très forte pression démographique (plus de 70 habitants/km²). Pour comprendre les pratiques ...

Genotipificación de aislamientos de Bartonella bacilliformis por amplificación de elementos repetitivos mediante el uso de REP-PCR y ERIC-PCR

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Carlos Padilla R

2003-07-01

Full Text Available Objetivos: Genotipificar los aislamientos de Bartonella bacilliformis a través de la amplificación de elementos repetitivos mediante el uso de ERIC-PCR y REP-PCR, y determinar si existe variabilidad genética entre aislamientos de varias zonas endémicas. Materiales y Métodos: Se evaluaron mediante el uso del ERIC-PCR y REP-PCR 17 aislamientos de B. bacilliformis de Lima, Cusco y Ancash. Los aislamientos fueron realizados durante los años 1998 y 1999. Para el análisis de los patrones de bandas se usó el software GelCompar 4,0. Resultados: Fueron identificados en los 17 aislamientos 10 genotipos. Los genotipos D, E y H fueron detectados en Cusco; mientras que los genotipos B, C, G, J e I en Lima; y el genotipo F en Ancash. Conclusiones: Nuestros resultados sugieren que REP-PCR y ERIC-PCR son métodos útiles para genotipificar aislamientos de B. bacilliformis. La variabilidad genética debe ser tomada en cuenta en estudios epidemiológicos y clínicos de Bartonelosis; así como el desarrollo de nuevas técnicas diagnósticas y de vacunas.

Elecciones 2016 en República Dominicana: Características, desafíos y retos desde la perspectiva electoral

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Roberto Rosario Márquez

2015-01-01

Full Text Available Expone la reforma electoral del año 2010, los aspectos importantes que se presentaron en las elecciones de 2012 y los retos que la Junta Central Electoral de la República Dominicana enfrenta en la organización y administración del proceso electoral del año 2016

RePS: a sequence assembler that masks exact repeats identified from the shotgun data

DEFF Research Database (Denmark)

Wang, Jun; Wong, Gane Ka-Shu; Ni, Peixiang

2002-01-01

We describe a sequence assembler, RePS (repeat-masked Phrap with scaffolding), that explicitly identifies exact 20mer repeats from the shotgun data and removes them prior to the assembly. The established software is used to compute meaningful error probabilities for each base. Clone......-end-pairing information is used to construct scaffolds that order and orient the contigs. We show with real data for human and rice that reasonable assemblies are possible even at coverages of only 4x to 6x, despite having up to 42.2% in exact repeats. Udgivelsesdato: 2002-May...

Leptospirosis porcina: prevalencia serológica en establecimientos productores de la República Argentina

OpenAIRE

Petrakovsky M, Jessica; Tinao, Julio; Esteves M, Jorge

2013-01-01

RESUMENObjetivo. Detectar la presencia de anticuerpos contra Leptospira sp en cerdos que no presentaban sintomatología clínica, pertenecientes a establecimientos de producción porcina ubicados en todo el territorio de la República Argentina. Materiales y métodos. La asignación de predios y muestras se realizó en forma proporcional a los registrados en cada provincia a lo largo de todo el país. En total se estudiaron 1.524 predios, de los cuales se tomaron 19.872 muestras de suero y en la prim...

El Gobierno de la República en el exilio : crónica de un imposible retorno

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Xavier Flores

2001-01-01

Full Text Available El triunfo de los aliados en la Segunda Guena Mundial hizo que los republicanos españoles exiliados en 1939 concibiesen esperanzas de un inmediato retomo de la República a su país con el apoyo aliado. Con esta idea se reconstituyeron las instituciones de la República Española en el exilio en México D. R, en agosto de 1945. En este artículo se analiza el proceso de esa reconstitución y los sucesivos gobiernos que se sucedieron hasta la disolución de las instituciones en junio de 1977, después de un imposible retorno.The victory of the salles in the Second World war did that the Spanish republicans exiled in 1939 were conceiving hopes ofan immediate return ofthe Republic to his(its country with the allied support. With this idea there were re-constituted the institutions of the Spanish Republic in the exile in México D.F., in August, 1945. In this article there are analyzed the process of this reconstitution and the successive governments that happened up to the dissolution of the institutions in June, 1977, afíer impossible I come back.

L'intégration des accélérateurs du CERN

CERN Document Server

Chemli, S; CERN. Geneva. TS Department

2008-01-01

L?intégration du LHC a ouvert des perspectives pour une gestion plus complète des accélérateurs du CERN. La base de données LAYOUT a permis d'assurer la continuité des phases de définition optique du projet, d'intégration 3D et de contrôles de conformité des installations. Les scans et modélisations 3D en couches des installations réalisées constituent un outil déterminant pour la préparation des interventions dans le cadre des procédures de sécurité ALARA. Il est proposé de reproduire cette méthodologie pour les nouveaux projets comme pour les accélérateurs existants. La mise à jour de l'anneau SPS dans LAYOUT semble être la priorité. La base de données SURVEY contient déjà une vue d'ensemble des accélérateurs, chaque composant étant référencé dans le Système de Coordonnées du CERN, selon les définitions théoriques "sources" au 1/100 mm. Base pour l'alignement, elle stocke également les positions réelles des machines. Elle complète ainsi l'information linéaire de LAY...

El intérprete de Lengua de Signos en el ámbito educativo: problemática y propuestas de mejora

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Marina Uría Fernández

2017-01-01

Full Text Available La figura del intérprete de Lengua de Signos es un recurso en el aprendizaje de los alumnos con discapacidad auditiva que contribuye al desarrollo de la experiencia bilingüe en los centros educativos españoles. Este estudio se centra en la figura del intérprete de Lengua de Signos como pieza fundamental en el entorno de aprendizaje del alumnado sordo en la Comunidad Autónoma de Castilla y León. El objetivo general del estudio es analizar los factores que obstaculizan y facilitan la labor del intérprete en los centros educativos de Castilla y León. Se ha utilizado una metodología de corte cualitativo de exploración descriptiva y evaluativa orientada a la decisión, utilizando el análisis DAFO para la interpretación de los resultados obtenidos. La muestra de este estudio ha estado constituida por diez intérpretes de Lengua de Signos que ejercían su profesión en centros públicos de Castilla y León durante el curso académico 2013/2014, seleccionados a través de la técnica cualitativa de informantes clave. Los resultados obtenidos destacan el desconocimiento del profesional intérprete de Lengua de Signos por parte de la comunidad educativa, la falta de criterios normativos que regulen equitativamente la participación de este profesional en el centro, y finalmente, la necesidad de una mayor integración de esta figura en el ámbito educativo para mejorar la calidad de la experiencia bilingüe de los alumnos sordos. Algunas de las propuestas más relevantes para superar los puntos débiles y potenciar los puntos fuertes identificados en el estudio son potenciar el trabajo en equipo entre todos los agentes educativos y sociales, la sensibilización y asesoramiento de toda la comunidad educativa y el desarrollo de estrategias individualizadas y adaptadas a las necesidades de cada uno de estos alumnos.

INT (2-(4-Iodophenyl)-3-(4-Nitrophenyl)-5-(Phenyl) Tetrazolium Chloride) Is Toxic to Prokaryote Cells Precluding Its Use with Whole Cells as a Proxy for In Vivo Respiration.

Science.gov (United States)

Villegas-Mendoza, Josué; Cajal-Medrano, Ramón; Maske, Helmut

2015-11-01

Prokaryote respiration is expected to be responsible for more than half of the community respiration in the ocean, but the lack of a practical method to measure the rate of prokaryote respiration in the open ocean resulted in very few published data leaving the role of organotrophic prokaryotes open to debate. Oxygen consumption rates of oceanic prokaryotes measured with current methods may be biased due to pre-incubation size filtration and long incubation times both of which can change the physiological and taxonomic profile of the sample during the incubation period. In vivo INT reduction has been used in terrestrial samples to estimate respiration rates, and recently, the method was introduced and applied in aquatic ecology. We measured oxygen consumption rates and in vivo INT reduction to formazan in cultures of marine bacterioplankton communities, Vibrio harveyi and the eukaryote Isochrysis galbana. For prokaryotes, we observed a decrease in oxygen consumption rates with increasing INT concentrations between 0.05 and 1 mM. Time series after 0.5 mM INT addition to prokaryote samples showed a burst of in vivo INT reduction to formazan and a rapid decline of oxygen consumption rates to zero within less than an hour. Our data for non-axenic eukaryote cultures suggest poisoning of the eukaryote. Prokaryotes are clearly poisoned by INT on time scales of less than 1 h, invalidating the interpretation of in vivo INT reduction to formazan as a proxy for oxygen consumption rates.

Estudo de práticas midiáticas a partir do produto: o jogo de espelhos de Profissão Repórter

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Mirian Meliani

2013-06-01

Full Text Available Analisar todas as nuances do discurso e das práticas adotadas pelo programa jornalístico Profissão Repórter, produzido pela Rede Globo, foi a tarefa realizada por jornalistas, pro- fessores e pós-graduandos ligados ao grupo de pesquisa MidiAto – Grupo de Estudos de Linguagem: Práticas Midiáticas, da Escola de Comunicações e Artes (ECA/USP. O resultado é uma exposição, bastante ampla, dos limites, das contradições e do papel desempenhado pelo programa na grade da emissora líder de audiência no Brasil, transcrita no livro Profissão Repórter em diálogo por meio de dezessete artigos.

A Primeira República Portuguesa (1910-1926: partidos e sistema político

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Baiôa, Manuel

2014-04-01

Full Text Available For historical, organisational, clientelist, violent and constitutional reasons the Portuguese Republican Party became the dominant party in the political system of the Portuguese First Republic (1910-1926. The opposition felt alternation via elections would be difficult to achieve so resorted to violent and unconstitutional practices to reach government. The Portuguese political parties modernised themselves in this period, but failed to turn into mass parties. In major cities they acted as a cadre party and in the rural area as a party of notables. The First Republic failed to take solid steps to democratise the political system were And Portugal remained tied to the liberal and elitist tradition of the nineteenth century, although in a republican version.El Partido Republicano Portugués se convirtió en el partido dominante del sistema político de la Primera República Portuguesa (1910-1926 debido a causas históricas, organizacionales, clientelistas, violentas y constitucionales. La oposición sentía que difícilmente conseguiría la alternancia política a través de elecciones, y por lo tanto, recurre a prácticas violentas e inconstitucionales para llegar al gobierno. Los partidos políticos portugueses se modernizaron en este período, pero no se convirtieron en partidos de masas. En las principales ciudades actuaban como partidos de cuadros y en las zonas rurales como partidos de notables. Durante la Primera República no se dieron pasos consistentes para democratizar el sistema político. Portugal se mantuvo ancorado a la tradición liberal y elitista del siglo XIX, aunque en una versión republicana.

Création d'outils pour la mesure de l'intégration des technologies de ...

International Development Research Centre (IDRC) Digital Library (Canada)

... dont les technologies de l'information et de la communication (TIC) sont intégrées en classe. ... Colombia, Mexico, Peru, Uruguay. Project Leader. Susana Martínez Restrepo. Institution. Fundación para la Educación Superior y el Desarrollo.

O leitor e as ‘fronteiras’ do universo fantástico na obra A República 3000, de Menotti del Picchia = The reader and the ‘borders’ of the fantastic universe in the book A República 3000, from Menotti del Picchia

Directory of Open Access Journals (Sweden)

Cristiano Mello de Oliveira

2012-01-01

Full Text Available No presente artigo pretendemos descortinar as relações entre os elementos fantásticos na obra A República 3000, do escritor Menotti del Picchia. Primeiramente iremos realizar uma breve recapitulação de alguns aspectos da literatura fantástica no Brasil. Posteriormente faremos recortes textuais, objetivando assim discutir aqueles que aproximem a linguagem com o universo fantástico. Tomaremos como referencial teórico os estudos de autores como Todorov e Carvalho. Também teceremos considerações sobre o comportamento do leitor diante dessa obra ímpar.This article aims to scrutinize the relationship of the fantastic elements in Menotti del Picchia’s work A República 3000. Firstly, we will briefly look at some aspects inherent to the Fantastic Literature in Brazil. Then we will select some excerpts whose language are closely related to the fantastic world. The theoretical framework draws on Todorov and Carvalho. We will also consider the possible reader’s degree of behavior in relation to the aforementioned masterpiece.

Facteurs associés à l’intégration stratégique des TIC par le personnel enseignant

OpenAIRE

Busana, Gilbert

2001-01-01

Ce mémoire porte sur les facteurs qui incitent le personnel enseignant à faire une intégration stratégique des TIC1. Nous avons remarqué qu’une partie des enseignants et des enseignantes, en faible proportion, réussissent à faire une telle intégration, et qu’une partie n’en font pas. L’objectif de cette recherche est d’identifier les facteurs qui tendent à avoir une influence sur ce phénomène, ainsi que de saisir leur rôle et de comprendre comment ils opèrent. Dans une premiè...

Pour que l'exploitation minière marche : intégrer des petits mineurs ...

International Development Research Centre (IDRC) Digital Library (Canada)

31 janv. 2011 ... Pour que l'exploitation minière marche : intégrer des petits mineurs pauvres dans ... ou reconnaissance de l'État est le mode de vie d'environ 13 millions de ... Selon l'Organisation internationale du travail (OIT), entre 11 et 13 millions ... mineurs subissent des discriminations et n'ont accès qu'aux parties les ...

Intégration régionale, commerce et essor du secteur privé (Namibie ...

International Development Research Centre (IDRC) Digital Library (Canada)

Intégration régionale, commerce et essor du secteur privé (Namibie). La Namibie aspire à atteindre un niveau de vie comparable à celui des pays développés d'ici 2030. Le Namibian Economic Policy Research Unit (NEPRU), le principal institut de recherche sur la politique économique du pays, a pour mandat d'aider le ...

Att sluta eller inte sluta : En litteraturstudie om tobaksavvänjningsmetoder

OpenAIRE

Bjellman, Karin

2007-01-01

Att sluta eller inte sluta? En litteraturstudie om tobaksavvänjningsmetoder Bjellman, K. Tobaksbruket har en lång historia, och de tobaksrelaterade sjukdomarna kostar samhället miljarder i sjukvårdskostnader och produktionsbortfall varje år. Andelen rökare minskar stadigt i Sverige, idag röker ca 15 procent av befolkningen. Resultaten från olika metoder för tobaksavvänjning är tämligen blygsamma, och ugefär nittio procent av de som slutar röka gör det på egen hand. Syftet med denna studie var...

Géohistoire de la Nouvelle-Zélande: unité territoriale et intégration à l’espace-monde

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François Cognard

2012-03-01

Full Text Available Tout au long de son histoire, la société néo-zélandaise s'est efforcée de nouer des liens avec le monde extérieur tout en maintenant l'intégrité de son territoire multi-insulaire. Selon une perspective privilégiant le temps long, cet article décrit les spécificités physiques et humaines de l'archipel du Pacifique sud ainsi que son processus d'intégration à l'économie monde. Une approche qui, à l'aide de la modélisation graphique, souligne l'originalité des dynamiques spatiales du territoire national caractérisées par l'opposition entre ses deux principales îles.

Rediseño y fabricación de una impresora 3D RepRap.

OpenAIRE

Huertas González, Joan

2014-01-01

El objetivo principal de este proyecto es conseguir las habilidades necesarias para fabricar una impresora 3D del tipo Rep Rap, una tipología de impresoras Open source. Una vez conseguido este objetivo se rediseñan piezas de la propia impresora con el objetivo de mejorar el diseño actual. Se plantea el proyecto como iniciación al mundo de la impresión 3D y de los materiales plásticos con los que se puede trabajar, PLA, HDPE, ABS o NYLON. Se instruye al lector para que tambié...

Macau no Contexto da Estratégia de Integração da República Popular da China no Mercado Mundial

OpenAIRE

Murteira, Mário

1994-01-01

Série II Especulação sobre o futuro de Macau perante a forte estratégia de intergração da República Popular da China no mercado mundial (com o desempenho de um papel influente por parte de Macau e Taiwan).

Ordem e Progresso: Augusto Comte e as influências do Positivismo na educação das mulheres na Primeira República brasileira

Directory of Open Access Journals (Sweden)

Loraine Lopes de Oliveira

2018-04-01

Full Text Available O presente artigo tem como objetivo apresentar uma reflexão acerca da influência do Positivismo na educação das mulheres no contexto da Primeira República brasileira (1889-1930, também chamada de República Velha. Faz-se uma breve abordagem inicial a respeito de Augusto Comte e o surgimento da filosofia positivista e posteriormente se discorre sobre a influência do Positivismo na educação das mulheres, a qual era vista como um elemento chave para a concretização da nova sociedade que se projetava, para o progresso e a modernização. A pesquisa tem caráter bibliográfico e fundamenta-se nos pressupostos teóricos do materialismo histórico-dialético, que busca compreender os fenômenos sociais e históricos a partir da existência material dos homens. A discussão prioriza a relação da educação com os fatores econômicos, políticos e sociais, já que se compreende que o objeto de pesquisa não pode ser entendido como uma situação isolada de seu contexto histórico. Palavras-chave: Positivismo. Primeira República Brasileira. Educação das mulheres.   Order and Progress: Augusto Comte and the influences of Positivism in the education of women in the First Brazilian Republic ABSTRACT The present article aims to present a reflection on the influence of positivism in the education of women in the context of the First Brazilian Republic (1889-1930, also called the Old Republic. A brief initial approach is given to Augusto Comte and the emergence of the positivist philosophy and later it talks about the influence of positivism in the education of women, a qualitative perspective as a key element for a concretization of the new society which was projected, for progress and modernization. The research has a bibliographic character and is based on the theoretical assumptions of historical-dialectical materialism, which seeks social and historical phenomena from the material reality of men. The discussion prioritizes the relationship

Insularité et démographie dans la mer Intérieure japonaise

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Philippe PELLETIER

1992-12-01

Full Text Available Les îles éloignées (ritô tiennent une place importante dans l’espace japonais. Les îles de la mer Intérieure se dépeuplèrent fortement pendant la Haute Croissance. Un graphique corrélant leur évolution démographique et leur distance par rapport à Honshû et Shikoku nous aide à comprendre que l’éloignement insulaire joua un rôle relatif.

Mise au point de la protection intégrée du colza : exemple du phoma (Leptosphaeria maculans

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Aubertot Jean-Noël

2003-05-01

Full Text Available En France, le phoma est considéré comme la maladie la plus préoccupante du colza. Il n’existe aucune méthode de lutte à la fois efficace, rentable et respectueuse de l’environnement. Il apparaît donc nécessaire de développer la lutte intégrée de la culture contre cette maladie. Cette communication présente les résultats d’un programme de recherche visant à analyser et à modéliser les effets des systèmes de culture sur le développement de la maladie. Des pistes concrètes pour la mise en oeuvre de la lutte intégrée contre le phoma sont proposées.

[Valitsusliidus olevad Reformierakond ning Isamaa ja Res Publica Liit on kavandatava koolireformi suhtes eri meelt] / Mailis Reps, Tiiu Kuurme, Karin Kütt

Index Scriptorium Estoniae

Reps, Mailis, 1975-

2010-01-01

Reformierakonna ettepaneku kohta jätta omavalitsustele õiguse otsustada, kas gümnaasium ja põhikool lahutatakse või jätkatakse ühendkooliga avaldavad arvamust riigikogu liige Mailis Reps, Tallinna Ülikooli dotsent Tiiu Kuurme ja Rannu keskkooli direktor Karin Kütt

Effective removal of a range of Ti/Ri plasmids using a pBBR1-type vector having a repABC operon and a lux reporter system.

Science.gov (United States)

Yamamoto, Shinji; Sakai, Ayako; Agustina, Vita; Moriguchi, Kazuki; Suzuki, Katsunori

2018-02-01

Ti and Ri plasmids of pathogenic Agrobacterium strains are stably maintained by the function of a repABC operon and have been classified into four incompatibility groups, namely, incRh1, incRh2, incRh3, and incRh4. Removal of these plasmids from their bacterial cells is an important step in determining strain-specific virulence characteristics and to construct strains useful for transformation. Here, we developed two powerful tools to improve this process. We first established a reporter system to detect the presence and absence of Ti/Ri plasmids in cells by using an acetosyringone (AS)-inducible promoter of the Ti2 small RNA and luxAB from Vibrio harveyi. This system distinguished a Ti/Ri plasmid-free cell colony among plasmid-harboring cell colonies by causing the latter colonies to emit light in response to AS. We then constructed new "Ti/Ri eviction plasmids," each of which carries a repABC from one of four Ti/Ri plasmids that belonged to incRh1, incRh2, incRh3, and incRh4 groups in the suicidal plasmid pK18mobsacB and in a broad-host-range pBBR1 vector. Introduction of the new eviction plasmids into Agrobacterium cells harboring the corresponding Ti/Ri plasmids led to Ti/Ri plasmid-free cells in every incRh group. The Ti/Ri eviction was more effective by plasmids with the pBBR1 backbone than by those with the pK18mobsacB backbone. Furthermore, the highly stable cryptic plasmid pAtC58 in A. tumefaciens C58 was effectively evicted by the introduction of a pBBR1 vector containing the repABC of pAtC58. These results indicate that the set of pBBR1-repABC plasmids is a powerful tool for the removal of stable rhizobial plasmids.

78 FR 53774 - Guide for the Evaluation of Alert and Notification Systems for Nuclear Power Plants, FEMA-REP-10...

Science.gov (United States)

2013-08-30

... available when FEMA REP-10 was first developed, such as smartphones and social media. Removes technical... proposed policy does not have the force or effect of law. FEMA seeks comment on the proposed policy, which... the force or effect of law. Authority: 6 U.S.C. 313-314a; Sec. 109, Pub. L. 96-295; E.O. 12148; 44 CFR...

Interações entre o aluno com surdez, o professor e o intérprete em aulas de física: uma perspectiva Vygotskiana

Directory of Open Access Journals (Sweden)

Jaqueline Santos Vargas

2014-09-01

Full Text Available O estudo apresenta uma análise das interações entre o aluno com surdez, o professor e o intérprete em sala de aula, além do papel desses sujeitos no processo de inclusão do aluno surdo. Trata-se de uma pesquisa qualitativa realizada em 10 escolas públicas de Ensino Médio de Campo Grande-MS que receberam 24 alunos com surdez. Nessa análise utilizamos a abordagem histórico cultural de Vygotsky. Os resultados evidenciaram que apenas o intérprete interage efetivamente com esses alunos e pouco colabora para que eles interajam com pessoas que não dominam a Língua Brasileira de Sinais. Em sala de aula, o professor transfere ao intérprete a responsabilidade pelo ensino e a aprendizagem desses alunos.

IntCal13 and Marine13 Radiocarbon Age Calibration Curves 0–50,000 Years cal BP

NARCIS (Netherlands)

Reimer, Paula J.; Bard, Edouard; Bayliss, Alex; Beck, J. Warren; Blackwell, Paul G.; Bronk Ramsey, Christopher; Buck, Caitlin E.; Cheng, Hai; Edwards, R. Lawrence; Friedrich, Michael; Grootes, Pieter M.; Guilderson, Thomas P.; Haflidason, Haflidi; Hajdas, Irka; Hatté, Christine; Heaton, Timothy J.; Hoffmann, Dirk L.; Hogg, Alan G.; Hughen, Konrad A.; Kaiser, K. Felix; Kromer, Bernd; Manning, Sturt W.; Niu, Mu; Reimer, Ron W.; Richards, David A.; Scott, E. Marian; Southon, John R.; Staff, Richard A.; Turney, Christian S.M.; Plicht, Johannes van der; Reimer, Paula J.

2013-01-01

The IntCal09 and Marine09 radiocarbon calibration curves have been revised utilizing newly available and updated data sets from C-14 measurements on tree rings, plant macrofossils, speleothems, corals, and foraminifera. The calibration curves were derived from the data using the random walk model

Summary Record of the First Meeting of the Radioactive Waste Repository Metadata Management (RepMet) Initiative

International Nuclear Information System (INIS)

2014-01-01

National radioactive waste repository programmes are collecting large amounts of data to support the long-term management of their nations' radioactive wastes. The data and related records increase in number, type and quality as programmes proceed through the successive stages of repository development: pre-siting, siting, characterisation, construction, operation and finally closure. Regulatory and societal approvals are included in this sequence. Some programmes are also documenting past repository projects and facing a challenge in allowing both current and future generations to understand actions carried out in the past. Metadata allows context to be stored with data and information so that it can be located, used, updated and maintained. Metadata helps waste management organisations better utilise their data in carrying out their statutory tasks and can also help verify and demonstrate that their programmes are appropriately driven. The NEA Radioactive Waste Repository Metadata Management (RepMet) initiative aims to bring about a better understanding of the identification and administration of metadata - a key aspect of data management - to support national programmes in managing their radioactive waste repository data, information and records in a way that is both harmonised internationally and suitable for long-term management and use. This is a summary record of the 1. meeting of the RepMet initiative. The actions and decisions from this meeting were sent separately to the group after the meeting, but are also included in this document (Annex A). The list of participants is attached as well (Annex B)

Adeno-associated virus Rep-mediated targeting of integrase-defective retroviral vector DNA circles into human chromosome 19

International Nuclear Information System (INIS)

Huang, Shuohao; Kawabe, Yoshinori; Ito, Akira; Kamihira, Masamichi

2012-01-01

Highlights: ► Adeno-associated virus (AAV) is capable of targeted integration in human cells. ► Integrase-defective retroviral vector (IDRV) enables a circular DNA delivery. ► A targeted integration system of IDRV DNA using the AAV integration mechanism. ► Targeted IDRV integration ameliorates the safety concerns for retroviral vectors. -- Abstract: Retroviral vectors have been employed in clinical trials for gene therapy owing to their relative large packaging capacity, alterable cell tropism, and chromosomal integration for stable transgene expression. However, uncontrollable integrations of transgenes are likely to cause safety issues, such as insertional mutagenesis. A targeted transgene integration system for retroviral vectors, therefore, is a straightforward way to address the insertional mutagenesis issue. Adeno-associated virus (AAV) is the only known virus capable of targeted integration in human cells. In the presence of AAV Rep proteins, plasmids possessing the p5 integration efficiency element (p5IEE) can be integrated into the AAV integration site (AAVS1) in the human genome. In this report, we describe a system that can target the circular DNA derived from non-integrating retroviral vectors to the AAVS1 site by utilizing the Rep/p5IEE integration mechanism. Our results showed that after G418 selection 30% of collected clones had retroviral DNA targeted at the AAVS1 site.

Current status of the ParInt package for parallel multivariate integration

International Nuclear Information System (INIS)

Doncker, E. de; Kaugars, K.; Cucos, L.; Zanny, R.

2002-01-01

The ParInt project focuses on the development of parallel algorithms and software for the computation of multi-variate integrals. We will give an overview of the contents and capabilities of the package. Our objective has been to provide the end-user with state of the art problem solving power. This has required work in a number of areas, including the fundamental numerical techniques, strategies for parallelization, user interfaces for general use and specific applications, and visualization of computations to analyze the mutual influences of problem characteristics and algorithm behavior. Furthermore, the integration of all the above into a versatile set of tools is aimed toward an efficient use of the available parallel or distributed computer resources. (author)

La disputa por la república en el siglo XIX y la prensa en México

OpenAIRE

Toussaint, Florence

2006-01-01

A partir de la consumación de la independencia, se inicia la disputa por definir el tipo de gobierno que había de asumir el país. Esta oscila entre la República federal y la centralista durante casi todo el tiempo, aunque hay dos momentos en los cuales la forma monárquica aparece como opción. Se conoce a estos periodos como el Primer Imperio y el Segundo Imperio. No duran muchos años. Sin embargo, dan lugar a enconadas luchas internas, sobre todo durante la presencia de...

Política externa do vizinho distante : estudo de caso da República Cooperativa da Guiana

OpenAIRE

Lima, Erick Cavalcanti Linhares

2012-01-01

Esta tese trata das relações externas da República Cooperativa da Guiana, num recorte temporal de quarenta e quatro anos, que vão desde a independência, em 1966 até 2010, período no qual se desenvolveram importantes transformações mundiais, bem como no relacionamento político-diplomático. Remontam a essa época, a formação do marco institucional de representação dos interesses sociais e produtivos, tanto na economia guianense, quanto no âmbito internacional. O objetivo foi traç...

Atomic effect algebras with compression bases

International Nuclear Information System (INIS)

Caragheorgheopol, Dan; Tkadlec, Josef

2011-01-01

Compression base effect algebras were recently introduced by Gudder [Demonstr. Math. 39, 43 (2006)]. They generalize sequential effect algebras [Rep. Math. Phys. 49, 87 (2002)] and compressible effect algebras [Rep. Math. Phys. 54, 93 (2004)]. The present paper focuses on atomic compression base effect algebras and the consequences of atoms being foci (so-called projections) of the compressions in the compression base. Part of our work generalizes results obtained in atomic sequential effect algebras by Tkadlec [Int. J. Theor. Phys. 47, 185 (2008)]. The notion of projection-atomicity is introduced and studied, and several conditions that force a compression base effect algebra or the set of its projections to be Boolean are found. Finally, we apply some of these results to sequential effect algebras and strengthen a previously established result concerning a sufficient condition for them to be Boolean.

L'initiative Samdrup Jongkhar, un modèle de développement intégré ...

International Development Research Centre (IDRC) Digital Library (Canada)

La Samdrup Jongkhar Initiative est un projet que la société civile a lancé dans le district du même nom, dans le but de favoriser un développement écologiquement responsable, en harmonie avec la philosophie holistique du Bhoutan qui vise à intégrer idéaux sociaux, économiques, culturels et environnementaux.

The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study

International Nuclear Information System (INIS)

Castillejo, Adela; Guillén-Ponce, Carmen; Carrato, Alfredo; Soto, José-Luís; Mata-Balaguer, Trinidad; Guarinos, Carla; Castillejo, María-Isabel; Martínez-Cantó, Ana; Barberá, Víctor-Manuel; Montenegro, Paola; Ochoa, Enrique; Lázaro, Rafael

2009-01-01

The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1) has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC) has not been established. The aims of this study were to assess the association of TGFBR1*Int7G24A variant with CRC occurrence, patient age, gender, tumour location and stage. We performed a case-control study with 504 cases of sporadic CRC; and 504 non-cancerous age, gender and ethnically matched controls. Genotyping analysis was performed using allelic discrimination assay by real time PCR. The Int7G24A variant was associated with increased CRC incidence in an additive model of inheritance (P for trend = 0.005). No significant differences were found between Int7G24A genotypes and tumour location or stage. Interestingly, the association of the Int7G24A variant with CRC risk was significant in men (odds ratio 4.10 with 95% confidence intervals 1.41-11.85 for homozygous individuals; P for trend = 0.00023), but not in women. We also observed an increase in susceptibility to CRC for individuals aged less than 70 years. Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population

Effect Of Smoking On Thyroid Status In Depression

OpenAIRE

Jalaj Saxena; P N Singh; Uma Srivastavaq; A Q Siddiqui

1997-01-01

Research Problem: Whal is Ihe impact of smoking cigarettes on thyroid functions in depression patients. Objective: To estimate T3, T4 and TSH in depressed smokers. Study Design:   Hospital   based clinical  study. Setting: Psychiatry out - door patients. Participants: Depression patients with or without history of smoking. Sample Size:     Twenty five  patients  of depression. Study Variables: Smoking, Non - smoking, T3 , T4 , TSH Statistical Analysis: Student t- test. Result: The patients of...

Intégration des TIC dans la gouvernance locale au Sénégal | IDRC ...

International Development Research Centre (IDRC) Digital Library (Canada)

Intégration des TIC dans la gouvernance locale au Sénégal. Ce projet s'inscrit dans le contexte de la mise en oeuvre du plan d'action du Somment mondial sur la société de l'information (SMSI). Ce plan met l'accent entre autres sur la nécessité d'un partenariat public-privé pour permettre aux collectivités africaines un ...

Gestion intégrée de l'eau urbaine et rurale pour une adaptation ...

International Development Research Centre (IDRC) Digital Library (Canada)

Ce projet de recherche permettra à deux villes indiennes de taille moyenne et à leurs bassins de passer à une approche de gestion de l'eau intégrée et résistante aux changements climatiques, ce qui assurera une meilleure sécurité hydrique aux résidents. Manque de sécurité hydrique en Inde Les villes de l'Asie du Sud ...

Management interculturel, altérité, et identités

CERN Document Server

Mutabazi, Evalde; Overveck Ottino, Saskia von; Pierre, Philippe

2014-01-01

Le management interculturel se fonde sur un effort permanent de remise en question de repères culturels acquis et ressentis comme universels. Ce livre s appuie sur des travaux de recherche et sur des témoignages d expériences pratiques, défend l urgence d un management interculturel au lieu d une gestion de la diversité risquant d assigner des individus à résidence identitaire, et intègre les apports de l ethnopsychanalyse.

Intégration régionale et politique des outre-mers

Directory of Open Access Journals (Sweden)

Didier Benjamin

1999-06-01

Full Text Available Grâce à ses outre-mers, qui lui apportent 96% de sa zone économique exclusive, la France dispose du troisième domaine maritime du monde et assure une présence sur tous les océans. Cependant, les outre-mers ne jouent plus qu'un rôle mineur dans la politique des océans. Ce paradoxe s'explique en partie par les difficultés qu'ils rencontrent à s'insérer dans les échanges internationaux et à s'intégrer aux organisations régionales. Les différences de niveaux de développement socioéconomique avec les pays voisins contribuent à isoler les outre-mers dans leur environnement immédiat.

The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study

Directory of Open Access Journals (Sweden)

Lázaro Rafael

2009-11-01

Full Text Available Abstract Background The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1 has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC has not been established. The aims of this study were to assess the association of TGFBR1*Int7G24A variant with CRC occurrence, patient age, gender, tumour location and stage. Methods We performed a case-control study with 504 cases of sporadic CRC; and 504 non-cancerous age, gender and ethnically matched controls. Genotyping analysis was performed using allelic discrimination assay by real time PCR. Results The Int7G24A variant was associated with increased CRC incidence in an additive model of inheritance (P for trend = 0.005. No significant differences were found between Int7G24A genotypes and tumour location or stage. Interestingly, the association of the Int7G24A variant with CRC risk was significant in men (odds ratio 4.10 with 95% confidence intervals 1.41-11.85 for homozygous individuals; P for trend = 0.00023, but not in women. We also observed an increase in susceptibility to CRC for individuals aged less than 70 years. Conclusion Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population.

Maquiavel Versus Rousseau: as Divisões Sociais e Seu Papel em uma República Bem-Ordenada

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Renato Moscateli

2015-01-01

Full Text Available RESUMO:As relações de conflito entre os grupos sociais constituem um tópico relevante para a filosofia política, e as maneiras distintas como elas são interpretadas dependem de uma visão mais ampla sobre as condições apropriadas a um Estado bem-ordenado. Maquiavel, por exemplo, ao refletir sobre o caso da Roma Antiga, procurou refutar aqueles que condenavam os tumultos entre os nobres e a plebe da cidade, como se eles tivessem provocado apenas males à república. Para o autor, tais tumultos estavam entre as principais causas da liberdade romana, visto que a diferença nos “humores” dos grandes e do povo resultou em embates que deram origem às leis favoráveis à liberdade. Rousseau, por sua vez, descreveu a existência de “associações particulares” dentro da sociedade civil como algo potencialmente nocivo à harmonia da república, pois cada uma delas contém um interesse particular passível de se sobrepor ao bem comum, nas deliberações públicas, prejudicando o prevalecimento da vontade geral. Ainda para o genebrino, a ocorrência de longos debates e de tumultos nas assembleias populares poderia ser um sinal de divisões internas capazes de ocasionar a ruína do Estado. Frente a essas duas maneiras de conceber o papel político dos conflitos sociais, o objetivo deste trabalho é realizar uma análise comparativa das ideias de Maquiavel e de Rousseau.

Las enseñanzas de sordomudos durante la II República Española. Una perspectiva histórica

Directory of Open Access Journals (Sweden)

Alfredo ALCINA MADUEÑO

2011-07-01

Full Text Available Las enseñanzas de sordomudos en el periodo de la II República española es un tema poco estudiado e inédito en determinados aspectos. Se puede decir que participa de las características de la educación general de dicha etapa: esfuerzo económico y presupuestario de los gobiernos, renovación metodológica, modernización del sistema, ampliación de la red escolar, formación del magisterio, etc., si bien presenta una idiosincrasia muy marcada e incluso contradictoria, no solo por la conocida contraposición de los gobiernos de un bienio y otro (31/33 y 34/35, sino también por las decisiones de política educativa que se toman por los mismos gobiernos de la coalición republicano-socialista. El legado de la aportación republicana es más documental que de realizaciones concretas, y tendrá mayor aplicación en el régimen político que aniquila y sucede a la República que en ella misma. La consideración de fuentes primarias (legales y documentales fundamentan principalmente las conclusiones de esta exposición.

El poder local en la provincia de Albacete durante la II República y el intervencionismo del gobierno, 1931-1936

Directory of Open Access Journals (Sweden)

Manuel REQUENA

2016-05-01

Full Text Available Este artículo estudia los diversos procesos electorales de carácter municipal durante la II República en la provincia de Albacete, las constantes interferencias del Gobierno de turno sustituyendo los consistorios democráticamente elegidos por gubernamentales, la lucha por el control del poder local y las medidas adoptadas para resolver los problemas locales y la conflictividad generada.

Alejandro Bunge y el problema de la vivienda obrera en la República Argentina (1910-1915

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Jorge A. Núñez

2010-02-01

Full Text Available Este trabajo pretende indagar, a partir del estudio de la figura del economista Alejandro Bunge, en la problemática de la vivienda obrera en la República Argentina en las primeras décadas de la pasada centuria. Aquí se argumentará que los estudios realizados porAlejandro Bunge como director de la División Estadísticas del Departamento Nacional de Trabajo en el período 1910-1915 contribuyeron de manera notable a la elaboración del proyectoy posterior sanción de la Ley de Casas Baratas para Obreros (n°9677.

La República peregrina: hombres de armas y letras en América Andina, 1810-1884

OpenAIRE

Thibaud, Clément

2014-01-01

Del 18 al 20 de mayo de 2005 se realizó en el Instituto de Estudios Peruanos el coloquio internacional «La República peregrina: Hombres de armas y letras en América Andina, 1810-1884». El evento, co-organizado por el Instituto Francés de Estudios Andinos y el IEP, reunió durante tres días a una veintena de historiadores especialistas en el siglo XIX, provenientes de todos los países andinos —de Chile hasta Venezuela, pasando por Argentina—, pero también de Inglaterra, Francia y Estados Unidos...

A Grande Guerra e as relações internacionais de Portugal: Da Monarquia à República

OpenAIRE

Castaño, David

2014-01-01

Neste artigo procuramos recuperar algumas das ideias que ajudam a explicar a participação portuguesa na Grande Guerra e a opção do Partido Democrático pelo envolvimento do País na frente europeia. Um pleno entendimento da participação portuguesa na Grande Guerra exige não apenas um recuo temporal, mas uma visão abrangente entre dinâmicas internas e externas. Nas primeiras, importa ter em consideração o binómio monarquia/república, e também as profundas divergências que rapidamente dividiram o...

Création d'outils pour la mesure de l'intégration des technologies de ...

International Development Research Centre (IDRC) Digital Library (Canada)

En collaborant avec les ministères de l'Éducation de la Colombie, du Mexique, du Pérou et de l'Uruguay, les chercheurs élaboreront des méthodologies communes et des indicateurs pertinents localement en vue de surveiller et de mesurer l'intégration des TIC en classe. Les résultats obtenus fourniront aux décideurs les ...

Intégration et coopération régionales en Afrique de l'Ouest | CRDI ...

International Development Research Centre (IDRC) Digital Library (Canada)

Épuisé. 406 pages. e-ISBN : 1552502988. Téléchargez le PDF · Téléchargez le cyberlivre. Cet ouvrage constate l'échec de l'intégration et de la coopération régionales en Afrique de l'Ouest et en analyse les raisons. Simultanément, il explore certaines des options permettant d'envisager la revitalisation de ce processus.

Mapa educativo nacional. Una experiencia en la República Argentina

Directory of Open Access Journals (Sweden)

Horacio Rodolfo Bozzano

2006-01-01

Full Text Available El Proyecto Mapa Educativo Nacional (MEN es un SIG generado a partir del desarrollo e integración de 24 Mapas Educativos Provinciales sobre la base de un modelo conceptual general, con una visión dinámica de los 49.000 establecimientos educativos, así como de su contexto territorial. Los objetivos del trabajo son: a sistematizar los aportes al Proyecto MEN desde la teoría cartográfica, reconociendo instancias de concepción, construcción y comunicación de los mapas que lo integran, así como vinculaciones entre territorio, espacio y espacialidades emergentes de la concreción de la tarea; y b identificar en qué medida la concreción del Proyecto MEN en la República Argentina contribuye a fortalecer un enfoque dialéctico conocimiento-realidad sobre el territorio y la gestión aplicado a un objeto de estudio e intervención concreto de desarrollo institucional, con el propósito de promover un círculo virtuoso de transformación entre sujetos de cambio y agentes de desarrollo.

Hombres de letras en la provincia. Producción y comercio de libros en la República de Colombia, 1821-1874

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Rafael E. Acevedo P.

2016-01-01

Full Text Available Han sido pocos los estudios en la historiografía nacional sobre el proceso de producción y comercialización de libros en la República de Colombia durante el siglo xix. A partir del análisis de las actividades de los impresores, los escritores de textos, los comerciantes y las autoridades políticas en Cartagena, en este artículo se demostrará que la difusión de las letras en la sociedad republicana estuvo sujeta a la dinámica de impresión y comercialización de obras de educación impulsada por los hombres de letras desde las provincias. Esta dinámica se constituyó en la base inicial de la formación de un pequeño mercado editorial en la República y fue posible gracias a los usos de la libertad de imprenta, las demandas de la alfabetización y las negociaciones de los autores con los gobiernos locales y nacionales. Se busca así contribuir al análisis de un problema sobre el que existen escasos trabajos en el contexto regional colombiano.

The IntFOLD server: an integrated web resource for protein fold recognition, 3D model quality assessment, intrinsic disorder prediction, domain prediction and ligand binding site prediction.

Science.gov (United States)

Roche, Daniel B; Buenavista, Maria T; Tetchner, Stuart J; McGuffin, Liam J

2011-07-01

The IntFOLD server is a novel independent server that integrates several cutting edge methods for the prediction of structure and function from sequence. Our guiding principles behind the server development were as follows: (i) to provide a simple unified resource that makes our prediction software accessible to all and (ii) to produce integrated output for predictions that can be easily interpreted. The output for predictions is presented as a simple table that summarizes all results graphically via plots and annotated 3D models. The raw machine readable data files for each set of predictions are also provided for developers, which comply with the Critical Assessment of Methods for Protein Structure Prediction (CASP) data standards. The server comprises an integrated suite of five novel methods: nFOLD4, for tertiary structure prediction; ModFOLD 3.0, for model quality assessment; DISOclust 2.0, for disorder prediction; DomFOLD 2.0 for domain prediction; and FunFOLD 1.0, for ligand binding site prediction. Predictions from the IntFOLD server were found to be competitive in several categories in the recent CASP9 experiment. The IntFOLD server is available at the following web site: http://www.reading.ac.uk/bioinf/IntFOLD/.

Elastic, vibration and thermodynamic properties of Cu1‑x Ag x InTe2 (x = 0, 0.25, 0.5, 0.75 and 1) chalcopyrite compounds via first principles

Science.gov (United States)

Zhong, Yuhan; Wang, Peida; Mei, Huayue; Jia, Zhenyuan; Cheng, Nanpu

2018-06-01

CuInTe2 chalcopyrite compound is widely used in the fields of optoelectronics and pyroelectricity, and doping atoms can further improve the physical properties of the CuInTe2 compound. For all we know, this is the first time that the elastic behaviors and lattice dynamical properties of Ag-doped CuInTe2 compounds with the tetragonal system are determined theoretically. The elastic, lattice dynamical and thermal properties of Cu1‑x Ag x InTe2 (x = 0, 0.25, 0.5, 0.75 and 1) compounds have been investigated by using density functional theory. The obtained elastic constants of Cu1‑x Ag x InTe2 compounds indicate that these compounds are mechanically stable and elastic anisotropic. The anisotropy of the {001} plane is more obvious than those of the {100} and {010} planes. Additionally, with increasing Ag doping concentrations, the bulk and shear moduli of Cu1‑x Ag x InTe2 compounds decrease and their toughness improves. The phonon spectra and density of states reveal that Cu (or Ag) atoms in Cu1‑x Ag x InTe2 compounds form chemical bonds with Te atoms, and Cu-Te bonds are gradually replaced by Ag-Te bonds with increasing Ag doping concentration. Vibration modes of Cu1‑x Ag x InTe2 compounds at the {{Γ }} point in the Brillouin zone show that each Cu1‑x Ag x InTe2 (x = 0 and 1) crystal includes five irreducible representations (A1, A2, B1, B2 and E). As for Cu1‑x Ag x InTe2 (x = 0.25, 0.5 and 0.75) compounds, each crystal has three irreducible representations (A, B and E). The atomic displacements of several typical phonon modes in CuInTe2 crystals have been analyzed to deepen the understanding of lattice vibrations in Cu1‑x AgxInTe2 compounds. With increasing Ag doping concentration, the Debye temperatures of Cu1‑x Ag x InTe2 compounds decrease, while their heat capacities increase.

João do Rio, Repórter da Pobreza na Cidade

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Denise da Costa Oliveira Siqueira

2004-06-01

Full Text Available Tendo como modelo a Belle Époque parisiense, o Rio de Janeiro, na virada do século XIX para o XX, sofria a transição para uma ordem capitalista urbana. Nesse contexto, o escritor e repórter João Paulo Barreto - o João do Rio - vagou pela cidade, observou parcelas da sociedade que raramente figuravam nas páginas de livros e jornais. No livro A Alma Encantadora das Ruas dedicou um capítulo às várias formas de pobreza e exploração presentes na capital federal. A partir dessa temática, o objetivo deste artigo é estudar as representações da pobreza como apresentadas no livro de João do Rio e paralelamente abordar a questão do texto jornalístico como mediador simbólico - reflexo de um tempo e de uma cultura.

Hybrid lentivirus-phiC31-int-NLS vector allows site-specific recombination in murine and human cells but induces DNA damage.

Directory of Open Access Journals (Sweden)

Nicolas Grandchamp

Full Text Available Gene transfer allows transient or permanent genetic modifications of cells for experimental or therapeutic purposes. Gene delivery by HIV-derived lentiviral vector (LV is highly effective but the risk of insertional mutagenesis is important and the random/uncontrollable integration of the DNA vector can deregulate the cell transcriptional activity. Non Integrative Lentiviral Vectors (NILVs solve this issue in non-dividing cells, but they do not allow long term expression in dividing cells. In this context, obtaining stable expression while avoiding the problems inherent to unpredictable DNA vector integration requires the ability to control the integration site. One possibility is to use the integrase of phage phiC31 (phiC31-int which catalyzes efficient site-specific recombination between the attP site in the phage genome and the chromosomal attB site of its Streptomyces host. Previous studies showed that phiC31-int is active in many eukaryotic cells, such as murine or human cells, and directs the integration of a DNA substrate into pseudo attP sites (pattP which are homologous to the native attP site. In this study, we combined the efficiency of NILV for gene delivery and the specificity of phiC31-int for DNA substrate integration to engineer a hybrid tool for gene transfer with the aim of allowing long term expression in dividing and non-dividing cells preventing genotoxicity. We demonstrated the feasibility to target NILV integration in human and murine pattP sites with a dual NILV vectors system: one which delivers phiC31-int, the other which constitute the substrate containing an attB site in its DNA sequence. These promising results are however alleviated by the occurrence of significant DNA damages. Further improvements are thus required to prevent chromosomal rearrangements for a therapeutic use of the system. However, its use as a tool for experimental applications such as transgenesis is already applicable.

Potestades Administrativas para Denegar Solicitudes de Derechos de Aguas Subterráneas y Retroactividad: Dictamen N° 5.215, de la Contraloría General de la República, de 31 de enero de 2006

OpenAIRE

Vergara Blanco, Alejandro

2007-01-01

Comenta favorablemente el autor un dictamen de la Contraloría General de la República relativo al otorgamiento de derechos de aprovechamiento de aguas por la Dirección General de Aguas, en el cual se precisan las causales de denegación de su concesión y asimismo se aclara la limitada retroactividad de la reciente Ley Nº 20.017, de 2005, modificatoria del Código de Aguas. The autor comments favourably upon a decision from the Contraloría General de la República (the Chilean Authority whose ...

Un ministro para la Defensa de la República desde el exilio : Juan Hernández Saravia

Directory of Open Access Journals (Sweden)

Manuela Aroca Mohedano

2004-01-01

Full Text Available La nueva situación internacionai surgida tras el final de la II Guerra Mundial propició la recuperación de las instituciones republicanas españolas en el exilio. Juan Hernández Saravia, un militar profesional, azañista y republicano, será el ministro de la Defensa Nacional de la República Española. Entre posibilidades reales y utopías, a caballo entre la defensa a ultranza de la legalidad y la protección de los movimientos clandestinos antifranquistas, en medio de las disensiones de los militares exiliados dispersos en varios continentes, discurrirá la actuación de un Ministerio que tendrá como objetivo principal la recuperación del ejército para la futura restaurada República y que verá truncadas sus expectativas por la aparición en el panorama mundial de los primeros.A Minister in exile for tfie Republic Defence: Juan Hernández Saravia The new International situation arisen after the end of the Second World War led to the recovery of Spanish Republic Institutions in exile. Juan Hernández Saravia, an army officer, republican and adherent to Azaña, became the National Defence Minister of Spanish Republic. Among real possibilities and utopia, halfway between a vigorous legality defence and the protection of clandestino movements against Franco's dictatorship, the main objective of this Ministery was the army recovery for the futuro restoring Republic, but the early Cold War shattered these prospects.

RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling

OpenAIRE

Kar, Ananya; Kaur, Manpreet; Ghosh, Tanushree; Khan, Md. Muntaz; Sharma, Aparna; Shekhar, Ritu; Varshney, Akhil; Saxena, Sandeep

2015-01-01

The primary eukaryotic single-stranded DNA-binding protein, Replication protein A (RPA), binds to single-stranded DNA at the sites of DNA damage and recruits the apical checkpoint kinase, ATR via its partner protein, ATRIP. It has been demonstrated that absence of RPA incapacitates the ATR-mediated checkpoint response. We report that in the absence of RPA, human single-stranded DNA-binding protein 1 (hSSB1) and its partner protein INTS3 form sub-nuclear foci, associate with the ATR-ATRIP comp...

Le label « bateaux d’intérêt patrimonial »

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Herveline Delhumeau

2009-05-01

Full Text Available Le label « bateaux d’intérêt patrimonial » s’inscrit pleinement dans les missions de la Fondation du patrimoine maritime et fluvial qui a pour vocation d’inventorier, de sauvegarder, de préserver et de promouvoir le patrimoine maritime et fluvial national non protégé par l’État. (fig. n°1Figure 1Belote et Re, thonier-chalutier traditionnel, construit en 1957 à Saint-Gilles Croix-de-Vie. Ce bateau est la dernière coque en bois réalisée par le chantier Bénéteau-père. © Fondation du Patrimoine ...

U.S. Rep. Dave Weldon outside the U.S. Lab Destiny in the SSPF.

Science.gov (United States)

1999-01-01

In the Space Station Processing Facility, U.S. Rep Dave Weldon (at left) looks at the U.S. Lab, called Destiny. With him are Thomas R. 'Randy' Galloway, with the Space Station Hardware Integration Office, Dana Gartzke, the congressman's chief of staffm and Boeing workers. Weldon is on the House Science Committee and vice chairman of the Space and Aeronautics Subcommittee. Destiny is scheduled to be launched on Space Shuttle Endeavour in early 2000. It will become the centerpiece of scientific research on the ISS, with five equipment racks aboard to provide essential functions for station systems, including high data-rate communications, and to maintain the station's orientation using control gyroscopes launched earlier. Additional equipment and research racks will be installed in the laboratory on subsequent Shuttle flights.

Influencia del campo magnético sobre el crecimiento de microorganismos patógenos ambientales aislados en el Archivo Nacional de la República de Cuba

Directory of Open Access Journals (Sweden)

Matilde Anaya

2015-09-01

Conclusión. Se concluyó que el campo magnético aplicado tuvo un efecto estimulante sobre los microorganismos estudiados, lo cual potencia el riesgo para la salud del personal y los visitantes del Archivo Nacional de la República de Cuba.

Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.

Science.gov (United States)

Dahlin, Joakim S; Malinovschi, Andrei; Öhrvik, Helena; Sandelin, Martin; Janson, Christer; Alving, Kjell; Hallgren, Jenny

2016-01-28

Mast cells are rare tissue-resident immune cells that are involved in allergic reactions, and their numbers are increased in the lungs of asthmatics. Murine lung mast cells arise from committed bone marrow-derived progenitors that enter the blood circulation, migrate through the pulmonary endothelium, and mature in the tissue. In humans, mast cells can be cultured from multipotent CD34(+) progenitor cells. However, a population of distinct precursor cells that give rise to mast cells has remained undiscovered. To our knowledge, this is the first report of human lineage-negative (Lin(-)) CD34(hi) CD117(int/hi) FcεRI(+) progenitor cells, which represented only 0.0053% of the isolated blood cells in healthy individuals. These cells expressed integrin β7 and developed a mast cell-like phenotype, although with a slow cell division capacity in vitro. Isolated Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells had an immature mast cell-like appearance and expressed high levels of many mast cell-related genes as compared with human blood basophils in whole-transcriptome microarray analyses. Furthermore, serglycin, tryptase, and carboxypeptidase A messenger RNA transcripts were detected by quantitative reverse transcription-polymerase chain reaction. Altogether, we propose that the Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells are closely related to human tissue mast cells and likely constitute an immediate precursor population, which can give rise to predominantly mast cells. Furthermore, asthmatics with reduced lung function had a higher frequency of Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood mast cell progenitors than asthmatics with normal lung function. © 2016 by The American Society of Hematology.

Aliados, tránsfugas y barrilitos: las elecciones legislativas de 2010 en República Dominicana

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Ana Belén BENITO SÁNCHEZ

2011-03-01

Full Text Available Este artículo analiza las claves explicativas de los resultados de las elecciones legislativas y municipales de 2010 en República Dominicana así como de la reciente transformación que ha experimentado el sistema de partidos dominicano, del tripartidismo al bipartidismo plural. El liderazgo del presidente Leonel Fernández, su imagen, popularidad y pragmatismo son la clave del éxito electoral del PLD, favorecido también por el faccionalismo endémico del PRD y la descomposición progresiva del PRSC. En esta contienda, el PLD consolida su dominio electoral gracias al apoyo de los partidos minoritarios y se asegura el control del Legislativo durante los próximos seis años.

El debate entre liberales y conservadores en Centroamérica : distintos medios para un objetivo connún, la construcción de una república de ciudadanos (1821-1900

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Sonia Alda Mejías

2000-01-01

Full Text Available La aspiración común de los liberales y los conservadores en Centroamérica en el siglo XIX fue construir una república representativa de ciudadanos instruidos y formados. La diferencia radico en cómo realizar este proceso de transformación. Este debate determinó en buena parte la evolución de la ciudadanía y los diferentes modelos de república implantados a lo largo del siglo XIX en la región. Mediante el estudio comparado de la legislación electoral y los textos constitucionales se comprueba la existencia de tres modelos de república diferentes en coherencia con la forma en que ambos grupos concibieron la forma, el ritmo y los medios para lograr un objetivo compartido por ambos.The common goal of liberals and conservatives In Centroamérica during the nineteeth century was the construction of a representative republic constituted by formed and instructed citizens. Tfie difference among them was how to perform this transformation process. The debate determined basically the evolution of citizenship and the distinctive modela of republican order implanted during the century. Through the comparative analysis of electoral legislatlon and ttie Cartas Magnas can be preved tfie existence of three different republican models according withi tlie common goal of the two already mentioned groups.

Paternité des articles et intérêts concurrents : une analyse des recommandations aux auteurs des journaux traitant de pratique pharmaceutique

Science.gov (United States)

Courbon, Ève; Tanguay, Cynthia; Lebel, Denis; Bussières, Jean-François

2014-01-01

RÉSUMÉ Contexte : La présence d’auteurs honorifiques et fantômes ainsi que les intérêts concurrents représentent des difficultés bien documentées, liées à la publication d’articles scientifiques. Il existe des lignes directrices encadrant la rédaction et la publication de manuscrits scientifiques, notamment celles de l’International Committee of Medical Journal Editors (ICMJE). Objectifs : L’objectif principal de cette étude descriptive et transversale visait à recenser les instructions portant sur la paternité des articles et les intérêts concurrents provenant des recommandations aux auteurs des journaux traitant de pratique pharmaceutique. L’objectif secondaire visait à déterminer des mesures correctrices pour une paternité des articles plus transparente. Méthode : La recherche a débuté par l’identification des journaux traitant de pratique pharmaceutique. La consultation des instructions aux auteurs des journaux a permis ensuite de recenser les recommandations destinées à éviter les problèmes de paternité des articles et d’intérêts concurrents. Finalement, les membres de l’équipe de recherche se sont consultés afin de définir des mesures correctrices possibles à l’intention des chercheurs. Résultats : Des 232 journaux traitant de pharmacie, 33 ont été définis comme traitant de pratique pharmaceutique. Un total de 24 (73 %) journaux mentionnaient suivre la politique de l’ICMJE, 14 (42 %) demandaient aux auteurs de remplir un formulaire de déclaration d’intérêts concurrents au moment de la soumission de l’article, 17 (52 %) présentaient une définition de la qualité d’auteur et 5 (15 %) demandaient de détailler les contributions de chaque auteur. Une grille de 40 critères a été élaborée pour définir l’attribution du statut d’auteur. Conclusion : Moins de la moitié des journaux demandait aux auteurs de transmettre un formulaire de déclaration des intérêts concurrents au moment de la

Patrimonio arqueológico e identidades en la República Dominicana

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Jorge Ulloa Hung

2009-03-01

Full Text Available Se abordan algunos de los principales problemas que presenta el estudio y conservación del patrimonio arqueológico de la República Dominicana a la luz de los nuevos retos y problemas que ha generado la globalización, así como de otras deformaciones impuestas por determinados procesos históricos y políticos dentro de la historia del país. El análisis también intenta hacer un llamado a la conservación y estudio del patrimonio arqueológico dominicano a la luz de nuevos conceptos y categorías usadas para el estudio del tema en el campo de la arqueología y la sociología, en especial, el punto de vista que prioriza la actividad de los agentes sociales. Por último, se intentan puntualizar aspectos que se consideran esenciales para generar una visión distinta en el abordaje del patrimonio arqueológico y que, a larga, podrían redundar en el desarrollo de una percepción distinta sobre la disciplina arqueol��gica en el país.

Effect of curing ingredients and vacuum packaging on the physico-chemical and storage quality of ready-to-eat Vawksa rep (smoked pork product) during refrigerated storage.

Science.gov (United States)

Deuri, Deepshikha; Hazarika, Pragati; Singh, Tarun Pal; Chhangte, Lalchamliani; Singh, Parminder; Talukder, Suman

2016-06-01

The present study was conducted for the development of ready-to-eat Vawksa rep (smoked pork product) and to study the synergistic effect of curing ingredients and vacuum packaging on the physico-chemical and storage quality during refrigerated storage at (4°C±1°C) for 15 days. Four different batches of Vawksa rep samples were prepared, i.e., T-1 (uncured, first cooked at 121°C for 15 min, and then smoked at 120°C for 30 min), T-2 (uncured, cooked, and smoked simultaneously at 120°C for 45 min), T-3 (cured, first cooked at 121°C for 15 min, and then smoked at 120°C for 30 min), and T-4 (cured, cooked, and smoked simultaneously at 120°C for 45 min). Cooking yield was significantly higher (pproduct) could be prepared easily with little technology up-gradation and with a negligible escalation of production cost.

Emerging contaminants and nutrients synergistically affect the spread of class 1 integron-integrase (intI1) and sul1 genes within stable streambed bacterial communities.

Science.gov (United States)

Subirats, Jèssica; Timoner, Xisca; Sànchez-Melsió, Alexandre; Balcázar, José Luis; Acuña, Vicenç; Sabater, Sergi; Borrego, Carles M

2018-07-01

Wastewater effluents increase the nutrient load of receiving streams while introducing a myriad of anthropogenic chemical pollutants that challenge the resident aquatic (micro)biota. Disentangling the effects of both kind of stressors and their potential interaction on the dissemination of antibiotic resistance genes in bacterial communities requires highly controlled manipulative experiments. In this work, we investigated the effects of a combined regime of nutrients (at low, medium and high concentrations) and a mixture of emerging contaminants (ciprofloxacin, erythromycin, sulfamethoxazole, diclofenac, and methylparaben) on the bacterial composition, abundance and antibiotic resistance profile of biofilms grown in artificial streams. In particular, we investigated the effect of this combined stress on genes encoding resistance to ciprofloxacin (qnrS), erythromycin (ermB), sulfamethoxazole (sul1 and sul2) as well as the class 1 integron-integrase gene (intI1). Only genes conferring resistance to sulfonamides (sul1 and sul2) and intI1 gene were detected in all treatments during the study period. Besides, bacterial communities exposed to emerging contaminants showed higher copy numbers of sul1 and intI1 genes than those not exposed, whereas nutrient amendments did not affect their abundance. However, bacterial communities exposed to both emerging contaminants and a high nutrient concentration (1, 25 and 1 mg L -1 of phosphate, nitrate and ammonium, respectively) showed the highest increase on the abundance of sul1 and intI1 genes thus suggesting a factors synergistic effect of both stressors. Since none of the treatments caused a significant change on the composition of bacterial communities, the enrichment of sul1 and intI1 genes within the community was caused by their dissemination under the combined pressure exerted by nutrients and emerging contaminants. To the best of our knowledge, this is the first study demonstrating the contribution of nutrients on

The Dual Half-Arc data structure: towards the universal B-rep data structure

DEFF Research Database (Denmark)

Anton, François; Bugoslawski, P.; Mioc, Darka

2014-01-01

, or more generally, the topology of any topological space. For this purpose, we generalize an existing data structure from 2D to 3D and design a new 3D data structure that realizes the synthesis between an existing 3D data structure (the Dual Half-Edge (See Footonote 1) data structure) and the generalized...... 3D Quad-Arc data structure, (See Footonote 2) and at the same time, improves the Dual Half-Edge towards a simpler and more effective representation of cell complexes through B-rep structures. We generalize the idea of the Quad-Arc data structure from 2D to 3D, but instead of transforming a simple...... edge of the Quad-Edge data structure to an arc with multiple points along it, we group together primal edges of the Dual Half-Edge that have the same dual Half-Edge vertex tags (volume tags) into one Dual Half-Arc whose dual is the common Dual Half-Edge and primal faces corresponding to dual...

Plantes alimentaires d'intérêt médicinal utilisées par les Pygmées ...

African Journals Online (AJOL)

L'usage des plantes dans les thérapies traditionnelles et en alimentation est primordial pour les populations des zones tropicales en général et celles des zones forestières et principalement des Pygmées en particulier. Le présent article contribue à la connaissance des plantes alimentaires d'intérêt médicinal utilisées en ...

U.S. Rep. Dave Weldon looks at the U.S. Lab Destiny in the SSPF.

Science.gov (United States)

1999-01-01

In the Space Station Processing Facility, Thomas R. 'Randy' Galloway, with the Space Station Hardware Integration Office, points out a feature to U.S. Rep. Dave Weldon (right) in the U.S. Lab, called 'Destiny.' In the far background is Dana Gartzke, the congressman's chief of staff. Weldon is on the House Science Committee and vice chairman of the Space and Aeronautics Subcommittee. Destiny is scheduled to be launched on Space Shuttle Endeavour in early 2000. It will become the centerpiece of scientific research on the ISS, with five equipment racks aboard to provide essential functions for station systems, including high data-rate communications, and to maintain the station's orientation using control gyroscopes launched earlier. Additional equipment and research racks will be installed in the laboratory on subsequent Shuttle flights.

Effect of curing ingredients and vacuum packaging on the physicochemical and storage quality of ready-to-eat Vawksa rep (smoked pork product during refrigerated storage

Directory of Open Access Journals (Sweden)

Deepshikha Deuri

2016-06-01

Full Text Available Aim: The present study was conducted for the development of ready-to-eat Vawksa rep (smoked pork product and to study the synergistic effect of curing ingredients and vacuum packaging on the physico-chemical and storage quality during refrigerated storage at (4°C±1°C for 15 days. Materials and Methods: Four different batches of Vawksa rep samples were prepared, i.e., T-1 (uncured, first cooked at 121°C for 15 min, and then smoked at 120°C for 30 min, T-2 (uncured, cooked, and smoked simultaneously at 120°C for 45 min, T-3 (cured, first cooked at 121°C for 15 min, and then smoked at 120°C for 30 min, and T-4 (cured, cooked, and smoked simultaneously at 120°C for 45 min. Results: Cooking yield was significantly higher (p<0.05 for the T-4. The pH of T-3 and T-4 samples was significantly higher (p<0.05 on day 15. The tyrosine value of all the samples increased significantly (p<0.05 among the different days of analysis. Thiobarbituric acid value was significantly (p<0.05 lower in T-3 sample both at the beginning and at the end of storage period. In microbiological profile, total plate count was lower in T-3 and T-4 than T-1 and T-2. However, Escherichia coli count was negative for T-3 and T-4 samples throughout the storage period. Among sensory attributes, T-3 and T-4 samples registered superior scores for color, flavor, texture, juiciness, and overall acceptability. Conclusion: Furthermore, Vawksa rep (smoked pork product could be prepared easily with little technology up-gradation and with a negligible escalation of production cost.

provincia de Buenos Aires (República Argentina

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Rubén Alberto Cervini

2008-01-01

Full Text Available En el estudio que se informa se investigaron las relaciones entre progreso de aprendizaje (valor agregado, motivación y autoconcepto académico del alumno en Matemática, en el marco de los efectos de las características socioeconómicas y académicas del alumno y de su escuela. Para la medición del valor agregado se utilizaron los resultados de dos pruebas estandarizadas de Matemática aplicadas a una cohorte de alumnos de la Provincia de Buenos Aires (República Argentina en dos momentos diferentes (séptimo y noveno años de Educación General Bási ca - EGB. Las mediciones de motivación y de autoconcepto se basaron en respuestas a ítemes binarios de actitudes con respecto a Ma temática y fueron definidas utilizando el análisis de la componente prin - cipal, a partir de la matriz de correlación tetracórica (método heurístico. Para el análisis de las correlaciones se utilizó la téc nica estadística de modelos multinivel. El presente estudio relaciona los resultados empíricos con la teoría del habitus de Bourdieu. Inicialmente, el autoconcepto resulta significativa y positivamente asociado con el puntaje en la prueba y con el progreso de aprendizaje posterior. Este efecto continúa siendo significati vo aun cuando se controlan los efectos del nivel socioeconómi - co y del género del alumno. Sin embargo, su capacidad ex plicativa es muy tenue desde el punto de vista práctico. Si bien este resultado confirmaría la hipótesis central de la teoría de la reproducción, indica un sendero a través del cual podrían producirse transformaciones. Uno de los desafíos del sistema educativo es promover el habitus escolar cultivado (autoconcepto más allá de las determinaciones sociales, culturales y económicas.

Spectral analysis of the IntCal98 calibration curve: a Bayesian view

International Nuclear Information System (INIS)

Palonen, V.; Tikkanen, P.

2004-01-01

Preliminary results from a Bayesian approach to find periodicities in the IntCal98 calibration curve are given. It has been shown in the literature that the discrete Fourier transform (Schuster periodogram) corresponds to the use of an approximate Bayesian model of one harmonic frequency and Gaussian noise. Advantages of the Bayesian approach include the possibility to use models for variable, attenuated and multiple frequencies, the capability to analyze unevenly spaced data and the possibility to assess the significance and uncertainties of spectral estimates. In this work, a new Bayesian model using random walk noise to take care of the trend in the data is developed. Both Bayesian models are described and the first results of the new model are reported and compared with results from straightforward discrete-Fourier-transform and maximum-entropy-method spectral analyses

Marché du carbone et solutions de gestion intégrée des déchets ...

International Development Research Centre (IDRC) Digital Library (Canada)

Marché du carbone et solutions de gestion intégrée des déchets : étude de cas menée en Indonésie. Le Mécanisme de développement propre (MDP) prévu au Protocole de Kyoto signé en 1997 a le double objectif d'aider les pays en développement à connaître un développement durable (tel que défini par chaque pays) ...

Las relaciones culturales de España en tiempo de crisis: de la II República a la Guerra Mundial

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Lorenzo Delgado Gómez-Escalonilla

1994-01-01

Full Text Available En los primeros meses de 1936 el personal de la Junta de Relaciones Culturales preparaba la memoria correspondiente al año anterior. Se daba continuidad con ella a la difusión de las actividades del organismo, comenzada tras el establecimiento de la II República, y que contaba ya con las publicaciones relativas a los años 1931-1933 y 1934. Esa preocupación por divulgar los resultados de su labor era una muestra más del dinamismo que había adquirido la Junta de Relaciones Culturales después de la reforma que experimentó en 1931. También recordaba a la actuación de la Junta para Ampliación de Estudios, que editaba sistemáticamente las memorias de sus actividades para dejar constancia pública del trabajo realizado. La analogía a este respecto no era casual. Con la república los intelectuales reformistas procedentes de la Institución Libre de Enseñanza, que tiempo atrás inspiraron la creación de la Junta para Ampliación de Estudios, habían recuperado el predicamento sobre la planificación de la política cultural con el extranjero. Pero la memoria de la Junta del año 1935 nunca llegó a aparecer. La guerra civil se cruzó en el camino de quienes la redactaban.

Intérprete, tu serás Interpreter, you will be

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Márcia Atálla Pietroluongo

2011-12-01

Full Text Available País bilíngue, fundamental no campo dos Estudos da Tradução por suas pesquisas em Terminologia e em Tradução jurídica, o Canadá promoveu e promove inúmeras iniciativas públicas, através de seu Bureau de Traduction, dentre outros organismos, para responder às diversas necessidades nacionais internas. O presente trabalho apresentará um acórdão da Corte Suprema da Nova-Escócia, província do Canadá, conhecido na jurisprudência canadense como o Acórdão Tran (1994, importante documento que estabeleceu pela primeira vez critérios para a fundamentação da "boa interpretação" no meio judicial. Tal decisão da Corte canadense foi incorporada ao Guia para Intérpretes Judiciários, do Ministério da Justiça do Quebec - Direção Geral dos Serviços de Justiça e dos Registros (janeiro de 2001, com edição revista em 2008, traduzido e adaptado por Pierrette Richard, Intérprete Judiciária no Palácio de Justiça de Montreal, do Freelance Court Interpreter's (1995, produzido pelo Serviço de Interpretação Judiciária do Ministério do Procurador Geral de Ontario.A bilingual country, essential in the Translation Studies field for its research on Terminology and Legal Translation, Canada has promoted in the past, and still does, multiple public initiatives, through its Bureau de Traduction, among other bodies, in order to respond to its various national internal needs. This work will present an appellate decision to the Supreme Court of Nova Scotia, a Canadian province, referred in case law as the Tran Decision (1994, an important document which for the first time has set forth the criteria for the grounds of "good interpretation" in the judicial milieu. Such decision from the Canada Court was included in the Guide for Court Interpreters, issued by the Quebec Ministry of Justice - General Direction of Justice and Registration Services (January 2001, revised in 2008, translated and adapted by Pierrette Richard, Court Interpreter in

La discrimination : une frontière par rapport à l’intégration

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Rosita Fibbi

2010-12-01

Full Text Available La Suisse s’est dotée d’une politique officielle d’intégration qui s’adresse prioritairement aux nouveaux immigrants. Toutefois les difficultés d’intégration concernent également la jeunesse d’origine immigrée qui réside dans le pays depuis des années. Deux études menées au Forum suisse pour l’étude des migrations et de la population montrent que ces jeunes sont confrontés à la discrimination à l’entrée sur le marché du travail, même lorsqu’ils disposent de qualifications identiques à celles de leurs congénères.Discrimination: a boundary to integrationSwitzerland has developed an official policy of integration with a priority accorded to new immigrants. However, integration difficulties concern also young people of immigrant origins who have lived in the country for a long time. Two studies carried out by the Swiss Forum for the Study of Migrations and the Population show that these young individuals are confronted with discrimination when they seek to enter the work force, even when they dispose of identical qualifications to those of their generation.La discriminación como barrera fronteriza contra la immigraciónSuiza se ha dotado de una política oficial dirigida prioritariamente a los imigrantes recientes. Sin embargo las dificultades de la integración atañen tambien a los jovenes de origen extranjero que residen en el pais desde hace años. Dos estudios realizados por el Foro suizo para el estudio de las migraciones y de la población ponen en evidencia que esos jovenes estan confrontados a la discriminación cuando llegan a la edad de trabajar aunque posean el mismo nivel de cualificación que los autoctonos.

Intérprete de libras em atuação na Educação Infantil e no Ensino Fundamental

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Simone Ferreira Conforto

2017-02-01

Full Text Available Neste texto bastante instigante, a autora nos traz uma grande reflexão do que seria a interpretação/ tradução fazendo uma comparação entre este dois campos. Assim, em relação à interpretação traduzir não é apenas trocar de uma língua para outra, é fundamental definir os sentidos do que se quer e deseja traduzir. Outros autores porém se referem à interpretação e tradução como sendo duas tarefas distintas e na verdade, traduzir é versar de uma língua para outra e interpretar envolveria relações pessoais. Para a autora, na verdade, o que acontece é que o intérprete se envolve em relações sociais e diálogos face a face. Então, o tradutor/intérprete precisa sempre agir com rapidez em suas escolhas e não tem como refletir, sobre o que está interpretando.

Las relaciones culturales de España en tiempo de crisis: de la II República a la Guerra Mundial

OpenAIRE

Lorenzo Delgado Gómez-Escalonilla

1994-01-01

En los primeros meses de 1936 el personal de la Junta de Relaciones Culturales preparaba la memoria correspondiente al año anterior. Se daba continuidad con ella a la difusión de las actividades del organismo, comenzada tras el establecimiento de la II República, y que contaba ya con las publicaciones relativas a los años 1931-1933 y 1934. Esa preocupación por divulgar los resultados de su labor era una muestra más del dinamismo que había adquirido la Junta de Relaciones ...

One-loop light-cone QCD, effective action for reggeized gluons and QCD RFT calculus

Energy Technology Data Exchange (ETDEWEB)

Bondarenko, S.; Pozdnyakov, S.; Prygarin, A. [Ariel University, Physics Department, Ariel (Israel); Lipatov, L. [St. Petersburg State University, St. Petersburg (Russian Federation); Petersburg Nuclear Physics Institute, Gatchina (Russian Federation)

2017-09-15

The effective action for reggeized gluons is based on the gluodynamic Yang-Mills Lagrangian with external current for longitudinal gluons added, see Lipatov (Nucl Phys B 452:369, 1995; Phys Rep 286:131, 1997; Subnucl Ser 49:131, 2013; Int J Mod Phys Conf Ser 39:1560082, 2015; Int J Mod Phys A 31(28/29):1645011, 2016; EPJ Web Conf 125:01010, 2016). On the base of classical solutions, obtained in Bondarenko et al. (Eur Phys J C 77(8):527, 2017), the one-loop corrections to this effective action in light-cone gauge are calculated. The RFT calculus for reggeized gluons similarly to the RFT introduced in Gribov (Sov Phys JETP 26:414, 1968) is proposed and discussed. The correctness of the results is verified by calculation of the propagators of A{sub +} and A{sub -} reggeized gluons fields and application of the obtained results is discussed as well. (orig.)

La República Federal de Alemania ante el fin de las dictaduras ibéricas (1974-1976): miradas entrecruzadas

OpenAIRE

Sanz Díaz, Carlos

2012-01-01

El papel protagonista de la República Federal de Alemania, por medio principalmente de su gobierno, partidos y fundaciones políticas, y sindicatos, en las transiciones ibéricas ha sido puesto de manifiesto desde los primeros estudios sobre la dimensión internacional de los cambios de régimen político en Portugal y España en 1974-1975. Este artículo pretende contribuir al conocimiento del «factor alemán» en las transiciones ibéricas subrayando la percepción que se tenía desde Bonn de la peníns...

Synthesis and characterization of Cu3TaIn3Se7 and CuTa2InTe4

International Nuclear Information System (INIS)

Calderon, E.; Munoz-Pinto, M.; Duran-Pina, S.; Quintero, M.; Quintero, E.; Morocoima, M.; Delgado, G.E.; Romero, H.; Briceno, J.M.; Fernandez, J.; Grima-Gallardo, P.

2008-01-01

Polycrystalline samples of Cu 3 TaIn 3 Se 7 and CuTa 2 InTe 4 were synthesized by the usual melt and anneal technique. X-ray powder diffraction showed a single phase behavior for both samples with tetragonal symmetry and unit cell parameter values a=5.794±0.002 A, c=11.66±0.01 A, c/a=2.01, V=391±1 A 3 and a=6.193±0.001 A, c=12.400 ±0.002A, c/a=2.00, V=475±1 A 3 , respectively. Differential thermal analysis (DTA) measurements suggested a complicated behavior near the melting point with several thermal transitions observed in the heating and cooling runs. From the shape of the DTA peaks it was deduced that the melting is incongruent for both materials. Magnetic susceptibility measurements (zero-field cooling and field cooling) indicated an antiferromagnetic character with transition temperatures of T=70 K (Cu 3 TaIn 3 Se 7 ) and 42 K (CuTa 2 InTe 4 ). A spin-glass transition was observed in Cu 3 TaIn 3 Se 7 with T f ∼50 K. (copyright 2008 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

Host Factors Influencing the Retrohoming Pathway of Group II Intron RmInt1, Which Has an Intron-Encoded Protein Naturally Devoid of Endonuclease Activity.

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Rafael Nisa-Martínez

Full Text Available Bacterial group II introns are self-splicing catalytic RNAs and mobile retroelements that have an open reading frame encoding an intron-encoded protein (IEP with reverse transcriptase (RT and RNA splicing or maturase activity. Some IEPs carry a DNA endonuclease (En domain, which is required to cleave the bottom strand downstream from the intron-insertion site for target DNA-primed reverse transcription (TPRT of the inserted intron RNA. Host factors complete the insertion of the intron. By contrast, the major retrohoming pathway of introns with IEPs naturally lacking endonuclease activity, like the Sinorhizobium meliloti intron RmInt1, is thought to involve insertion of the intron RNA into the template for lagging strand DNA synthesis ahead of the replication fork, with possible use of the nascent strand to prime reverse transcription of the intron RNA. The host factors influencing the retrohoming pathway of such introns have not yet been described. Here, we identify key candidates likely to be involved in early and late steps of RmInt1 retrohoming. Some of these host factors are common to En+ group II intron retrohoming, but some have different functions. Our results also suggest that the retrohoming process of RmInt1 may be less dependent on the intracellular free Mg2+ concentration than those of other group II introns.

U.S. Rep. Dave Weldon looks at the U.S. Lab Destiny in the SSPF.

Science.gov (United States)

1999-01-01

In the cockpit of the orbiter Atlantis, which is in the Orbiter Processing Facility, Laural Patrick (left), a systems engineer with MEDS, points out a feature of the newly installed Multifunction Electronic Display Subsystem (MEDS), known as the 'glass cockpit,' to U.S. Rep. Dave Weldon. The congressman is on the House Science Committee and vice chairman of the Space and Aeronautics Subcommittee. He was in Palmdale, Calif., when Atlantis underwent the modification and he wanted to see the final product. The full-color, flat-panel MEDS upgrade improves crew/orbiter interaction with easy-to-read, graphic portrayals of key flight indicators like attitude display and mach speed. The installation makes Atlantis the most modern orbiter in the fleet and equals the systems on current commercial jet airliners and military aircraft. Atlantis is scheduled to fly on mission STS- 101 in early December.

Los intérpretes generales de Yucatán: hombres entre dos mundos

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Mark Lentz

2009-01-01

Full Text Available Este artículo se centra en un tipo importante de intermediarios en el Yucatán colonial, los intérpretes generales del Juzgado Privado de Indios de Yucatán. Desde la época de Gaspar Antonio Chi en 1580 hasta la desaparición de esta corte en la década de 1820, estos hombres mediaron directamente en disputas de propiedades, quejas contra las autoridades, y tradujeron decretos inicialmente publicados en español para la mayoría maya hablante de la provincia. Sus actividades demuestran que Yucatán poseyó un alto número de individuos que dominaron tanto el maya como el español hasta finales del periodo colonial. Además, la cantidad de individuos calificados sirviendo extra oficial mente como intérpretes durante finales del siglo dieciocho, y el sorprendente número de no-mayas que necesitaron sus servicios, muestran también que el periodo colonial fue una época en la que el maya se extendió como lenguaje predominante en Yucatán, en lugar de una época de declive para ese idioma.This paper focuses one type of important intermediaries of colonial Yucatan, the general interpreters of Yucatan's Juzgado Privado de Indios. From the time of Gaspar Antonio Chi in 1580 until the demise of this court in the 1820s, these men mediated directly in land disputes, complaints against priests and other officials, and translated decrees initially published in Spanish for the province's Maya-speaking majority. The activities of the interpreters demonstrate that Yucatan had a high number of individuals literate and fluent in both Maya and Spanish until the close of the colonial period. Furthermore, the quantity of qualified individuals serving unofficially as interpreters during the late eighteenth century and the surprising number of non-Mayas in need of their services also shows that the colonial period was a time in which Maya spread as the predominant language of Yucatan rather than a time of decline for the region's native language.

Contribution à l'étude de la gestion intégrée de la fertilité du sol pour ...

African Journals Online (AJOL)

Contribution à l'étude de la gestion intégrée de la fertilité du sol pour la culture de maïs (Zea mays) dans la Région de Mbujimayi, RDC. Michel Nkongolo Mulambuila, Jean Michel Mutombo Tshibamba, Justin Cibanda Mutombo, Pierrot Muka Mulamba, Thèrese Masengu Tshibuyi, Grégoire Tshibangu Kabongo ...

High-resolution observations in the western Mediterranean Sea: the REP14-MED experiment

Science.gov (United States)

Onken, Reiner; Fiekas, Heinz-Volker; Beguery, Laurent; Borrione, Ines; Funk, Andreas; Hemming, Michael; Hernandez-Lasheras, Jaime; Heywood, Karen J.; Kaiser, Jan; Knoll, Michaela; Mourre, Baptiste; Oddo, Paolo; Poulain, Pierre-Marie; Queste, Bastien Y.; Russo, Aniello; Shitashima, Kiminori; Siderius, Martin; Thorp Küsel, Elizabeth

2018-04-01

The observational part of the REP14-MED experiment was conducted in June 2014 in the Sardo-Balearic Basin west of Sardinia (western Mediterranean Sea). Two research vessels collected high-resolution oceanographic data by means of hydrographic casts, towed systems, and underway measurements. In addition, a vast amount of data was provided by a fleet of 11 ocean gliders, time series were available from moored instruments, and information on Lagrangian flow patterns was obtained from surface drifters and one profiling float. The spatial resolution of the observations encompasses a spectrum over 4 orders of magnitude from 𝒪(101 m) to 𝒪(105 m), and the time series from the moored instruments cover a spectral range of 5 orders from 𝒪(101 s) to 𝒪(106 s). The objective of this article is to provide an overview of the huge data set which has been utilised by various studies, focusing on (i) water masses and circulation, (ii) operational forecasting, (iii) data assimilation, (iv) variability of the ocean, and (v) new payloads for gliders.

Chikungunya en la República Dominicana: lecciones aprendidas en los primeros seis meses

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Raquel Pimentel

2014-11-01

Full Text Available La epidemia de chikungunya en la República Dominicana se inició en febrero de 2014. En los primeros seis meses se registraron 429 421 casos, que representaron 65% de todos los notificados a la Organización Panamericana de la Salud por 33 países y territorios de la Región de las Américas. Esta epidemia se ha transmitido con rapidez en dicho país y ha demandado una intensa respuesta intersectorial, que ha liderado el Ministerio de Salud Pública y, especialmente, el Sistema Nacional de Vigilancia Epidemiológica y la red de los servicios de salud. Considerando que afectará a miles de personas, el objetivo de este artículo es describir las actuaciones realizadas y compartir los resultados y las lecciones aprendidas durante estos primeros meses con los ministerios de salud y los profesionales de los países de la Región para ayudarles a preparar una respuesta adecuada para afrontarla de forma efectiva y eficiente.

La misión de Carlos Baraibar en Marruecos durante la guerra civil

OpenAIRE

Luna Alonso, Miguel Antonio

2002-01-01

A partir de la documentación hallada en el Archivo del Ministerio de Asuntos Exteriores (Madrid), Serie República, procedente en su mayoría de los agentes consulares de España en el Protectorado de Francia en Marruecos y otros funcionarios del Ministerio de Estado, este artículo aporta numerosos detalles inéditos del conocido intento de levantar las cabilas de la zona española de Marruecos que Largo Caballero encargó a Carlos Baraibar, y una interpretación hipotética en clave de política inte...

Las migraciones transnacionales en Asia Central como amenaza a la seguridad de las ex-repúblicas soviéticas (1991-2014)

OpenAIRE

Calderón Bocanegra, Camilo Alberto

2015-01-01

Esta monografía tiene como objetivo explicar cómo las migraciones transnacionales se han convertido en una amenaza para la seguridad de las ex repúblicas soviéticas de Asia central durante las últimas dos décadas dando lugar a un Complejo de Seguridad Regional (CSR). Mediante la teoría crítica del CSR elaborada por Barry Buzan, se buscará probar que estos flujos migratorios transnacionales han configurado una amenaza compartida para la seguridad de la región debido a su asociación con grupos ...

Evaluación de la formación permanente del profesorado en la República Dominicana : el caso del Infocam

OpenAIRE

Ayala de la Cruz, María Esperanza

2016-01-01

El presente estudio estuvo orientado a describir y valorar la calidad del sistema de formación, relacionándolo con la aplicación de las políticas educativas y de formación permanente o continua del profesorado en la República Dominicana. Su conexión con las necesidades e intereses de los docentes, su incidencia en el desarrollo personal, profesional, y de desempeño. Teniendo como intención estratégica generar y aportar líneas para avanzar hacia un sistema de evaluación de la formación...

La disolución de la Asamblea Nacional como facultad del Presidente de la República: análisis comparativo

OpenAIRE

Torres Rosero, Galo Ramiro

2016-01-01

La Constitución del Ecuador 2008 incorporó una nueva figura jurídica denominada “la disolución de la Asamblea Nacional como facultad del Presidente de la República”. Esta institución es novísima en nuestro ordenamiento jurídico y, de acuerdo a los constituyentes de Montecristi, ha sido insertada en nuestra legislación con el propósito de garantizar el equilibrio de poderes entre las funciones del Estado. El objetivo de este trabajo es conocer a profundidad esta figura, que tuvo su origen en E...

Preliminary results on σZ and τint fluctuations as a function of incident energy in dissipative heavy ion collisions

International Nuclear Information System (INIS)

Berceanu, I.; Andronic, A.; Duma, M.

1998-01-01

Non-statistical fluctuations in the excitation functions (EF) of dissipative heavy ion collisions (DHIC) was rather unexpected due to the fact that cross sections are always obtained on a 'coarse cell' of TKEL and θ cm . The contribution of a large number of microchannels, N, is expected to attenuate the amplitude of such fluctuations as σ(E) has a χ 2 distribution with 2N degrees of freedom. In the framework of the Partially Overlapping Molecular Levels the observation of the fluctuations of the cross section as a function of the incident energy is explained by the fact that the levels of the dinuclear system formed in the first stage of a dissipative process are excited in a region of low density situated in the vicinity of the yrast line. The time evolution of dinuclear (DNS) system with different mass asymmetries with the total mass of the nuclear system 19 F + 27 Al system configuration and its time evolution, the excitation function for this system has been measured between 111.4 MeV and 136.9 MeV with a 250 keV energy step. Fluctuations with amplitude larger than the statistical errors were observed. Large Z and angular cross correlation coefficients show their nonstatistical nature. An average energy correlation width of 170±65 keV, to which corresponds a DNS lifetime τ int (3.9 ± 1.1)·10 -21 s, was obtained by the energy autocorrelation function (EAF). The experimental EAF secondary structure period agrees with that predicted by Kun model when the deformation of the outgoing fragments is taken into account. To get more insight in the reaction mechanism, the dependence of the charge distribution variance for two total kinetic energy loss windows, W1 = 20 ± 2.5 and W2 = 30 ± 2.5 MeV, was obtained as a function of E lab . The second moments of the experimental charge distributions have been calculated and the obtained values were represented for W1 and W2. Fluctuations with quite large amplitude are present. In a transport approach of deep inelastic

Les migrantes, la sécurité économique et le défi de la réintégration ...

International Development Research Centre (IDRC) Digital Library (Canada)

Ce projet portera sur la réintégration de Philippines revenant au pays après leur passage dans les importants centres d'activités de Hong Kong, Taïwan et Singapour. La recherche sera dirigée par aidha, un organisme à but non lucratif qui offre aux travailleuses migrantes, en particulier aux aides familiales, des formations ...

República, nación y democracia ante el desafío de la diversidad Republic, nation and democracy against the challenge of diversity

Directory of Open Access Journals (Sweden)

Susana Villavicencio

2010-12-01

Full Text Available La República no es sólo el nombre de una nación estado y su régimen. Es también un modelo nacional de integración basado en la concepción universalista de la ciudadanía que afirma la figura abstracta de la persona jurídica, portadora de iguales derechos y obligaciones, y valores de civismo y civilidad. Este trabajo analiza cómo la emergencia de la diversidad cultural en Argentina pone en cuestión los conceptos modernos de república, nación y democracia. Examina asimismo cómo los legados de la república, que supone una visión homogeneizada de la diversidad, implican una ambivalencia entre la adhesión a principios universalistas de progreso de la humanidad y la realidad de una democracia excluyente que valorizaba una cultura por sobre otras. Se estudian las narrativas de la identidad nacional, mostrando cómo la oposición civilización -barbarie afecta la visión de los desafíos del futuro de la democracia en América Latina.Republic is not only the name of a nation and its regime. It is also a national model of integration based on a universalist conception of citizenship that sustains the abstract figure of the legal person, endowed with equal rights and obligations, and values of civism and civility, the foundation stones of a society that arises from a contract. This paper analyses how the emergency of the cultural diversity in Argentina calls into question modern political concepts like republic, nation and democracy. It is also evaluated how the republic's inheritance, which supposes an homogenized sight of diversity, gives rise to an ambivalence among the adherence to universalist principles of the progress of humanity and the reality of an excluding democracy that gave value to one culture above others. The narratives of national identity are studied describing how the opposition between civilization and barbariy affects the way Latin Americans see the great challenges presented by the future of democracy, and by the

Uma ditadura contra a república: política econômica e poder político em Roberto Campos

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Ricardo V. Silva

2006-11-01

Full Text Available O artigo examina o pensamento político de Roberto Campos entre meados das décadas de 1950 e 1970. Neste período, além de importantes funções governamentais, Campos dedicou-se intensamente à luta de idéias, publicando grande quantidade de artigos e ensaios. Será desenvolvida a hipótese de que o seu pensamento político aponta para a institucionalização de um sistema político de tipo autoritário como o mais adequado às condições culturais e políticas da sociedade brasileira. A principal característica deste tipo de sistema consiste na hipertrofia do poder Executivo estatal, sob comando de militares e tecnocratas, relativamente aos demais poderes da República. A função primordial do poder Executivo hipertrofiado são a elaboração e a implementação de reformas institucionais e de políticas econômicas "racionais", contra as resistências pretensamente particularistas e irracionais dos diferentes setores da sociedade brasileira. Essa hipótese colide frontalmente com a sugestão de Campos de que o regime instituído após o movimento de 1964 seria uma espécie de atualização, nas condições da sociedade brasileira de então, do instituto da "ditadura comissária" da antiga República romana, pelo qual se permitia a eleição de um ditador por um curto período de tempo para debelar eventuais ameaças às instituições republicanas.

Élaboration d'une stratégie de lutte intégrée contre la pollution de l ...

International Development Research Centre (IDRC) Digital Library (Canada)

Élaboration d'une stratégie de lutte intégrée contre la pollution de l'eau à Yorito, au Honduras. Le Honduras connaît des problèmes chroniques de gestion des eaux usées et des déchets solides. Dans le cadre de réformes de décentralisation effectuées récemment, un projet de gestion des déchets axé sur la collectivité ...

Modernidade republicana e diocesanização do catolicismo no Brasil: as relações entre Estado e Igreja na Primeira República (1889-1930

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Maurício de Aquino

2012-01-01

Full Text Available Partindo da análise de documentação consultada em arquivos do Brasil e do Vaticano, o artigo discute as relações entre Estado e Igreja Católica Apostólica Romana (ICAR no período da Primeira República brasileira. Considera-se que a Proclamação da República em 15 de novembro de 1889 foi associada, por algumas parcelas das elites brasileiras da época, ao ideário do progresso e da civilização, sendo uma de suas primeiras tarefas a extinção do padroado em 7 de janeiro de 1890. O laicismo determinado nessa ocasião pelo Decreto 119-A revelou-se, entretanto, ambíguo e pragmático. Livre das amarras constitucionais do padroado, o Estado criou um novo campo de relações com as diferentes confissões religiosas, segundo os seus próprios interesses institucionais. Nesse contexto, a ICAR, por sua vez, empreendeu um processo de reforma e reorganização eclesiástica cujo fulcro consistiu na criação de dioceses e jurisdições similares - um amplo e complexo processo territorial, político e discursivo ao qual se pode denominar diocesanização.

Conventional Morphology Versus PCR Sequencing, rep-PCR, and MALDI-TOF-MS for Identification of Clinical Aspergillus Isolates Collected Over a 2-Year Period in a University Hospital at Kayseri, Turkey.

Science.gov (United States)

Atalay, Altay; Koc, Ayse Nedret; Suel, Ahmet; Sav, Hafize; Demir, Gonca; Elmali, Ferhan; Cakir, Nuri; Seyedmousavi, Seyedmojtaba

2016-09-01

Aspergillus species cause a wide range of diseases in humans, including allergies, localized infections, or fatal disseminated diseases. Rapid detection and identification of Aspergillus spp. facilitate effective patient management. In the current study we compared conventional morphological methods with PCR sequencing, rep-PCR, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) for the identification of Aspergillus strains. A total of 24 consecutive clinical isolates of Aspergillus were collected during 2012-2014. Conventional morphology and rep-PCR were performed in our Mycology Laboratory. The identification, evaluation, and reporting of strains using MALDI-TOF-MS were performed by BioMérieux Diagnostic, Inc. in Istanbul. DNA sequence analysis of the clinical isolates was performed by the BMLabosis laboratory in Ankara. Samples consisted of 18 (75%) lower respiratory tract specimens, 3 otomycosis (12.5%) ear tissues, 1 sample from keratitis, and 1 sample from a cutaneous wound. According to DNA sequence analysis, 12 (50%) specimens were identified as A. fumigatus, 8 (33.3%) as A. flavus, 3 (12.5%) as A. niger, and 1 (4.2%) as A. terreus. Statistically, there was good agreement between the conventional morphology and rep-PCR and MALDI-TOF methods; kappa values were κ = 0.869, 0.871, and 0.916, respectively (P < 0.001). The good level of agreement between the methods included in the present study and sequence method could be due to the identification of Aspergillus strains that were commonly encountered. Therefore, it was concluded that studies conducted with a higher number of isolates, which include other Aspergillus strains, are required. © 2016 Wiley Periodicals, Inc.

Homonota fasciata Duméril y Bibron, 1839 (Reptilia, Squamata, Phyllodactylidae. Primer registro para la provincia de Corrientes (República Argentina

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Falcione, Camila

2011-05-01

Full Text Available Homonota fasciata Duméril & Bibron, 1839. República Argentina, Provincia de Corrientes, Departamento Bella Vista, Cuarta Sección, Colonia Progreso, Loma Sur, Toropí (28°35'55" S; 59°03'38" W (Figura 1. Colectores: Eduardo Etchepare, María del Rosario Ingaramo, Camila Falcione y Roberto Aguirre. 05 de abril de 2011. Se colectaron 4 ejemplares adultos (2 machos y 2 hembras y 1 juvenil, depositados en la Colección Herpetológica de la Universidad Nacional del Nordeste (UNNEC-11212, UNNEC-11213, UNNEC- 11214, UNNEC-11215 y UNNEC-11216.

O intérprete universitário da Língua Brasileira de Sinais na cidade de Curitiba A sign language university level interpreter working in the city of Curitiba

Directory of Open Access Journals (Sweden)

Ana Cristina Guarinello

2008-04-01

Full Text Available No Brasil, o trabalho com intérpretes em Língua Brasileira de Sinais iniciou-se nos anos 80 e pode, dessa forma, ser considerado recente, assim como também é recente a legitimidade da sua importância que ainda está em processo de consolidação. A presente pesquisa tem como principal objetivo discutir e explicitar questões relativas ao trabalho de intérpretes de língua de sinais em uma universidade e dois centros universitários particulares da cidade de Curitiba. Para isto foram aplicados dois questionários para dois grupos distintos, um voltado para os intérpretes que atuam em universidades da cidade de Curitiba, e outro voltado para os surdos universitários que possuem intérpretes em sala de aula. Ambos os questionários continham questões abertas e fechadas. De acordo com as análises dos dados, constatou-se a importância dos intérpretes em sala de aula para o processo de aprendizagem dos estudantes surdos. Contudo, verificou-se também uma série de questões que subjaze a discussão sobre a efetividade no contexto da interpretação, tais como: qualidade na formação dos intérpretes, conhecimento antecipado da disciplina para a tradução, dificuldade na relação Língua Portuguesa/LIBRAS, relação intérprete/professor, dentre outras. A partir dessas considerações, vemos que, no cenário da educação dos surdos brasileiros, essas questões apenas refletem o descaso das autoridades com relação à educação dessa população, assim como evidenciam as dificuldades lingüísticas e sociais relativas à surdez. Esse trabalho apresenta-se, nessa direção, como o início de uma reflexão sobre o contexto do intérprete universitário, porém, muito ainda precisa ser entendido para que mudanças mais efetivas possam ser realizadas.In Brazil, work with Brazilian sign language (Libras interpreters began in the eighties, so this can be said to be a recent proposal, as is recent the consideration of sign language as a

Tratado de amistad, comercio y navegación entre la República de Colombia su Majestad el Rey del Reyno Unido de la Gran Bretaña e Irlanda en el nombre de la Santísima Trinidad

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Alvaro Acevedo Acevedo

2013-10-01

Full Text Available Habiéndose establecido estensas relaciones comerciales por una serie de años, entre varias provincias, ó países de América, que unidos ahora constituyen la República de Colombia, y los dominios de su Majestad el Rey del Reino Unido de la Gran Bretaña, é Irlanda, ha parecido conveniente, así para la seguridad y fomento de aquella correspondencia comercial, como para mantener la buena inteligencia entre su dicha Majestad, y la dicha República, que las relaciones que ahora subsisten entre ambas, sean regularmente conocidas y confirmadas por medio de un tratado de amistad, comercio y navegación.

INITIAL DATA RELEASE OF THE KEPLER-INT SURVEY

Energy Technology Data Exchange (ETDEWEB)

Greiss, S.; Steeghs, D.; Gaensicke, B. T. [Department of Physics, Astronomy and Astrophysics group, University of Warwick, CV4 7AL Coventry (United Kingdom); Martin, E. L. [INTA-CSIC Centro de Astrobiologia, Carretera de Ajalvir km 4, 28550 Torrejon de Ardoz (Spain); Groot, P. J.; Verbeek, K.; Jonker, P. G.; Scaringi, S. [Department of Astrophysics/IMAPP, Radboud University Nijmegen, P.O. Box 9010, 6500 GL Nijmegen (Netherlands); Irwin, M. J.; Gonzalez-Solares, E. [Cambridge Astronomy Survey Unit, Institute of Astronomy, University of Cambridge, Madingley Road, CB3 0HA Cambridge (United Kingdom); Greimel, R. [Institut fuer Physik, Karl-Franzen Universitaet Graz, Universitaetsplatz 5, 8010 Graz (Austria); Knigge, C. [School of Physics and Astronomy, University of Southampton, Southampton, Hampshire SO17 1BJ (United Kingdom); Ostensen, R. H. [Instituut voor Sterrenkunde, KU Leuven, Celestijnenlaan 200D, 3001 Leuven (Belgium); Drew, J. E.; Farnhill, H. [Centre for Astrophysics Research, University of Hertfordshire, College Lane, Hatfield AL10 9AB (United Kingdom); Drake, J.; Wright, N. J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Ripepi, V. [INAF-Osservatorio Astronomico di Capodimonte, via Moiariello 16, Naples I-80131 (Italy); Southworth, J. [Astrophysics Group, Keele University, Newcastle-under-Lyme ST5 5BG (United Kingdom); Still, M., E-mail: s.greiss@warwick.ac.uk [NASA Ames Research Center, M/S 244-40, Moffett Field, CA 94035 (United States); and others

2012-07-15

This paper describes the first data release of the Kepler-INT Survey (KIS) that covers a 116 deg{sup 2} region of the Cygnus and Lyra constellations. The Kepler field is the target of the most intensive search for transiting planets to date. Despite the fact that the Kepler mission provides superior time-series photometry, with an enormous impact on all areas of stellar variability, its field lacks optical photometry complete to the confusion limit of the Kepler instrument necessary for selecting various classes of targets. For this reason, we follow the observing strategy and data reduction method used in the IPHAS and UVEX galactic plane surveys in order to produce a deep optical survey of the Kepler field. This initial release concerns data taken between 2011 May and August, using the Isaac Newton Telescope on the island of La Palma. Four broadband filters were used, U, g, r, i, as well as one narrowband one, H{alpha}, reaching down to a 10{sigma} limit of {approx}20th mag in the Vega system. Observations covering {approx}50 deg{sup 2}, thus about half of the field, passed our quality control thresholds and constitute this first data release. We derive a global photometric calibration by placing the KIS magnitudes as close as possible to the Kepler Input Catalog (KIC) photometry. The initial data release catalog containing around 6 million sources from all the good photometric fields is available for download from the KIS Web site (www.astro.warwick.ac.uk/research/kis/) as well as via MAST (KIS magnitudes can be retrieved using the MAST enhanced target search page http://archive.stsci.edu/kepler/kepler{sub f}ov/search.php and also via Casjobs at MAST Web site http://mastweb.stsci.edu/kplrcasjobs/).

INITIAL DATA RELEASE OF THE KEPLER-INT SURVEY

International Nuclear Information System (INIS)

Greiss, S.; Steeghs, D.; Gänsicke, B. T.; Martín, E. L.; Groot, P. J.; Verbeek, K.; Jonker, P. G.; Scaringi, S.; Irwin, M. J.; González-Solares, E.; Greimel, R.; Knigge, C.; Østensen, R. H.; Drew, J. E.; Farnhill, H.; Drake, J.; Wright, N. J.; Ripepi, V.; Southworth, J.; Still, M.

2012-01-01

This paper describes the first data release of the Kepler-INT Survey (KIS) that covers a 116 deg 2 region of the Cygnus and Lyra constellations. The Kepler field is the target of the most intensive search for transiting planets to date. Despite the fact that the Kepler mission provides superior time-series photometry, with an enormous impact on all areas of stellar variability, its field lacks optical photometry complete to the confusion limit of the Kepler instrument necessary for selecting various classes of targets. For this reason, we follow the observing strategy and data reduction method used in the IPHAS and UVEX galactic plane surveys in order to produce a deep optical survey of the Kepler field. This initial release concerns data taken between 2011 May and August, using the Isaac Newton Telescope on the island of La Palma. Four broadband filters were used, U, g, r, i, as well as one narrowband one, Hα, reaching down to a 10σ limit of ∼20th mag in the Vega system. Observations covering ∼50 deg 2 , thus about half of the field, passed our quality control thresholds and constitute this first data release. We derive a global photometric calibration by placing the KIS magnitudes as close as possible to the Kepler Input Catalog (KIC) photometry. The initial data release catalog containing around 6 million sources from all the good photometric fields is available for download from the KIS Web site (www.astro.warwick.ac.uk/research/kis/) as well as via MAST (KIS magnitudes can be retrieved using the MAST enhanced target search page http://archive.stsci.edu/kepler/kepler_fov/search.php and also via Casjobs at MAST Web site http://mastweb.stsci.edu/kplrcasjobs/).

DE L’IRRATIONNEL AU RATIONNEL : QUAND LES ANIMAUX TIENNENT LE DISCOURS DE LA VÉRITÉ AUX HOMMES / FROM NON-RATIONALE TO RATIONALE: WHEN ANIMALS POSSESS TRUTH SPEECH TO HUMAN BEINGS / DE LA IRAŢIONAL LA RAŢIONAL: CÂND ANIMALELE DEŢIN DISCURSUL ADEVĂRULUI ÎN FAŢA FIINŢELOR UMANE

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Yao Lambert Konan

2013-11-01

Full Text Available Cette étude, qui s’est intéressée à la figuration faunesque dans les contes de l’Afrique noire, a saisi l’animal en tant que symbole thématique et force agissante. Le bestiaire dans l’univers narratif des textes oraux assume une triple fonctionnalité : véhiculer les idéaux de la société, indiquer les repères de conduite à tenir dans telle ou telle circonstance et se conformer aux normes communautaires. La symbolisation animale permet de déboucher sur la sagesse humaine, élément fondamental de la paix sociale.

De la República de las Letras a Internet: de la ciudad letrada a la cibercultura y las tecnologías del S. XXI

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Eloy Martos Núñez

2010-06-01

Full Text Available Describe la evolución del concepto de la “República de lasLetras” hacia un concepto más omnicomprensivo y tecnológico de“Ciudad Letrada” y sus implicaciones en los campos educativo y cultural. Se examinan igualmente otras controversias sobre el sentido de dichos conceptos aplicados a los contextos actuales y, en particular, en relación a Internet y los nuevos fenómenos de la sociedad de la información.

Intégration des Tice et apprentissage de l'enseignement : une approche systémique Integrating technology and learning to teach: a systemic perspective

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Francis Bangou

2006-11-01

Full Text Available De nombreuses études soulignent à quel point il est complexe d'analyser les changements pédagogiques entraînés par l'intégration des Tice. Cette recherche-action tente d'analyser de façon systémique les interrelations qu'entretient l'intégration des Tice avec les changements pédagogiques dans le cadre d'un programme de formation d'enseignants en langues étrangères au sein d'une grande université américaine. Le cadre théorique nous permettra tout d'abord de délimiter une perspective systémique et de présenter notre conception de l'intégration des Tice et de l'apprentissage. Puis, nous présenterons notre étude et en résumerons les principaux résultats afin d'illustrer la complexité d'une telle relation.Many studies underline how difficult it is to analyse the pedagogical changes caused by the integration of technology. This action research aims to analyse, from a systemic point of view, the interrelations that exist between the integration of technology and pedagogical change. The study took place in a foreign and second language teacher education program at a large American university. First, we will define a systemic perspective as well as the concepts of technology integration and learning. Then, to illustrate the complexity of such relationship, we will describe our study and summarize the main results.

Católicos, devociones y sociedad durante la Dictadura de Primo de Rivera y la Segunda República. La Obra del Amor Misericordioso en España (1922-1936). [Reseña

OpenAIRE

Illanes, J.L. (José Luis)

2009-01-01

Reseña de KM. REQUENA, Católicos, devociones y sociedad durante la Dictadura de Primo de Rivera y la Segunda República. La Obra del Amor Misericordioso en España (1922-1936), Biblioteca Nueva Madrid 2008, 359 pp., ISBN 978-84-9742-877-4.

La República de Guayaquil como sujeto de derecho internacional y su contribución en la formación del nuevo estado

OpenAIRE

Morán Herrera, Fernando Xavier

2014-01-01

El maestrante entrega tres ejemplares empastados de la tesis y tres CD con el contenido de la misma en formato PDF El presente trabajo contiene la independencia y la creación de la Provincia Libre de Guayaquil o República de Guayaquil, sus antecedentes sociales y económicos; así como las instituciones políticas civiles y militares, creadas con posterioridad a la emancipación, que sirvieron de base para la institucionalización y relativa estabilidad de un gobierno autónomo. Se narra el acc...

La divulgación radiofónica de la alimentación y la higiene infantil en la España de la Segunda República (1933-1935

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Josep Bernabeu Mestre

2011-01-01

Full Text Available El trabajo analiza la incorporación de medios tecnológicos, en particular la radio, en el proceso de divulgación del conocimiento sobre la salud infantil durante la Segunda República española. En el marco de la campaña sanitaria contra la mortalidad infantil que puso en marcha la Segunda República en la década del 30, la Asociación Española de Médicos Puericultores Titulados, en colaboración con Unión Radio, organizó dos ciclos de conferencias radiofónicas que pretendían explicar, a través de un discurso divulgativo de tono descriptivo dirigido a las clases populares, las nociones fundamentales de la higiene y la alimentación infantil, e impulsar una cultura de la prevención, guiada y orientada por los dictados de los expertos. Se trataba de una acción de propaganda y divulgación que tenía su continuidad en el medio familiar y comunitario a través de la actuación de las enfermeras visitadoras puericultoras, contemplando a las madres como población diana.

República Democrática del Congo: ¿El campo estéril de los olivos?

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Adriana María Ramírez López

2010-11-01

Full Text Available Los orígenes y las causas de la persistencia del conflicto en la República Democrática del Congo han sido explicados empleando argumentos simplificados que han tendido a minimizar la complejidad de los acontecimientos presentados en este país centroafricano desde la década de los noventa hasta el día de hoy. Estas explicaciones se caracterizan por su marcado carácter determinista y por ensombrecer aún más las perspectivas de paz de esta nación que se encuentra viviendo un coyuntural momento histórico. No obstante, una mirada más detallada al proceso de configuración del Estado poscolonial congoleño y a las dinámicas internacionales que han influido en su particular articulación pueden dar nuevas luces sobre el conflicto mismo, las causas de su prolongación y sus perspectivas de resolución.

La sociedad civil movilizada y las reformas democráticas en la República Dominicana

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Rosario Espinal

2001-01-01

Full Text Available En este artículo se identifican cinco periodos en el proceso de organización y movilización social que se produjo en la República Dominicana entre 1978 y 2000, el lapso más largo de apertura política que ha tenido el país. Se plantea que la naturaleza y la forma de estos movimientos ha variado como resultado de la situación económica, el partido en el poder, las estrategias de distintos gobiernos para ejercer control social sobre los grupos movilizados, el tipo de relación entre los partidos políticos y las organizaciones sociales y el financiamiento disponible para las organizaciones sociales. En cuanto al debate teórico sobre la relación entre movimientos sociales y democracia, se plantea que esta relación no es unívoca, y que en determinadas circunstancias los movimientos sociales pueden ayudar a la democratización y en otras a obstaculizarla

Comparaison de populations de carpe commune (Cyprinus carpio à taille commerciale : intérêt d'une approche globale

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PEREIRA V.

1999-07-01

Une discrimination géographique des populations est possible mais elle repose sur une approche globale intégrant l'ensemble des paramètres. Les différences semblent essentiellement liées aux conditions environnementales et permettent de distinguer les lots issus des régions où l'élevage est plus intensif et traditionnellement centré sur la carpe (Dombes, Forez, Lorraine et les lots correspondant à un élevage plus extensif et davantage orienté vers le marché du repeuplement (Allier, Brenne, Poitou-Charentes.

A Constituição da República de 1988 e a hierarquia dos Tratados de Direitos Humanos no ordenamento jurídico brasileiro

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Julio Cesar de Aguiar

2016-11-01

Full Text Available O presente artigo busca analisar o modo pelo qual o Direito brasileiro – em especial a Constituição da República de 1988 – se relaciona com os instrumentos internacionais de proteção aos direitos humanos, bem como abordar a problemática da hierarquização “diferenciada” e a contribuição ofertada por estes instrumentos para o aperfeiçoamento do ordenamento jurídico interno, em um contexto histórico do período pós-Segunda Guerra Mundial, quando a comunidade internacional passou não só a reconhecer, mas também a dar mais importância à proteção aos direitos humanos, os quais são questões de legítimos interesses e preocupação internacional. Por fim, apesar de prevalecer o entendimento - da jurisprudência do STF - de que os acordos que versem sobre direitos humanos, se aprovados no Congresso Nacional com quórum e procedimento de Emenda Constitucional, têm a mesma hierarquia da Constituição, caso contrário, adquirem status superior às leis complementares e ordinária e inferior à Constituição, status de supra legalidade, há ainda, a discussão para saber qual o verdadeiro sentido do parágrafo 3º do Art. 5º Constituição da República de 1988.

Intérprete surdo de língua de sinais brasileira: o novo campo de tradução / interpretação cultural e seu desafio

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Ana Regina e Souza Campello

2014-07-01

  Esse artigo é o resultado da pesquisa que trata da nova modalidade de tradução/interpretação de línguas de sinais dos intérpretes Surdos, observando a norma surda (STONE, 2009 apud SOUZA, 2010. Recentemente surgiu esse novo campo de tradução no contexto educacional do ensino a distância: o da tradução e interpretação do ator/tradutor e finalmente e intérprete de uma língua de sinais para outra língua de sinais (SEGALA, 2010; SOUZA, 2010. Estas atividades de tradução e interpretação têm sido desempenhadas por Surdos bilíngues intermodais. Exatamente por representar um novo campo de estudo, este artigo apresenta a sua constituição.

L'effet pro-concurrentiel de l'intégration européenne:

DEFF Research Database (Denmark)

Bellone, Flora; Musso, Patrick; Nesta, Lionel

En situation de concurrence pure et parfaite, les décisions par les entreprises de quantité produites et d'utilisation des facteurs s'effectuent en égalisant le prix du marché de bien final avec le coût marginal. En situation de concurrence imparfaite, cette égalisation n'est plus respectée, les...... firmes ayant intérêt d'utiliser leur pouvoir de marché pour fixer un prix au-delà de leur coût marginal. Dans cet article, nous mesurons les taux de marge, définis comme l'écart en pourcentage entre le prix de vente et le coût marginal, à partir de données d'entreprises pour 14 industries manufacturières...... françaises de 1986 à 2004. Nous observons que le taux de marge moyen, sur l'ensemble de la période et sur l'ensemble des industries, est de 13,8%, ce qui est légèrement supérieur au Royaume-Uni.  Nous trouvons que la mise en place du marché commun a conduit à une diminution de 4 à 5% des marges, alors que l...

Os intérpretes e a formação do Brasil: os quatro primeiros séculos de uma história esquecida

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Dennys Silva-Reis

2016-09-01

Full Text Available http://dx.doi.org/10.5007/2175-7968.2016v36n3p81 A formação histórica do Brasil muito deveu ao trabalho indispensável dos intérpretes desde o chamado “descobrimento” até bem avançado o século XIX. Neste artigo, destacamos a necessidade de conceder maior visibilidade aos intérpretes e à sua contribuição para a história cultural e linguística do Brasil, de modo que se comece a traçar um retrato mais fidedigno das complexas relações entre línguas, povos e culturas que caracterizaram os quatro primeiros séculos dessa história. Para tanto, destacamos o papel desses agentes culturais para uma reescrita da história da tradução no Brasil. Estes que permanecem marginalizados ou mesmo invisíveis na historiografia geral se tornam aqui agentes primordiais para a formação histórica do Brasil em todas as suas etapas.

La "Carta a los maestros" de Jules Ferry (1883 y el laicismo escolar de la IIIª República francesa

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Juan Manuel FERNÁNDEZ SORIA

2010-03-01

Full Text Available RESUMEN: Partiendo del valor histórico —de lo que es una muestra su influencia en la política educativa de la Segunda República española— y de la proyección de su legado en nuestros días de la «Carta a los Maestros» (1883 del ministro francés de Instrucción Pública, Jules Ferry, este trabajo se acerca a la vida de su autor y a su política educativa para analizar luego con mayor profundidad los aspectos más sobresalientes del documento —que transcribimos en francés y castellano—, especialmente el laicismo escolar, como medio de establecer una escuela nacional y de fundación de la República, la defensa de la moral común y positiva, los modos y procedimientos —tanto directos como indirectos— de su enseñanza, así como el papel del maestro y del manual en la educación moral y cívica del futuro ciudadano. ABSTRACT: Starting with the historic value —of which it is an example its influence in the educational policy of the Second Republic— and with the influence that remains in our days, of the legate of the «Elementary Schoolteacher’s Letter», written by Jules Ferry, French minister of the Public Instruction, this piece of work approaches to its author’s life and to its educational policy in order to analyse later in greater detail the most relevant aspects of the document —which we reproduce in Spanish and French— specially the scholastic laicism as a way to establish a national school, and the foundation of the Republic, the defence of common and positive morality, the ways and procedures, both direct and indirect, of its teaching, and also the role of schoolteachers and the guide in the moral and civic education of the future citizens.

Migración irregular de haitianos hacia república dominicana y sus implicaciones socio-económicas en el desarrollo de ambas naciones

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Ovalles Mejía, José Manuel; Uribe Mendoza, Cristhian José

2017-01-01

84 páginas : gráficos. Esta investigación analiza la migración irregular de haitianos hacia la República Dominicana y sus implicaciones socio-económicas en el desarrollo de ambas naciones durante el período 2010-2015. Este tema reviste gran importancia en el entendido de que los dos países analizados, con condiciones económicas, políticas, sociales y culturales con marcadas diferencias, hoy día comparten y conviven en una misma isla a causa del fenómeno de la migración. Se hace una des...

Del idealismo al realismo relaciones entre España y Corea desde la Segunda República hasta la Guerra de Corea (1931-1953)

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Choe, Hae Sung

2006-01-01

En las relaciones entre España y Corea hasta la entrada del siglo XX, predominaban un desinterés mutuo y escasos contactos. No obstante, llegó un nuevo período de atención sorprendente y de alto interés. El objetivo del presente trabajo es analizar y reconstruir las relaciones e influencias, imágenes y percepciones entre España y Corea durante dicho período comprendido entre la Segunda República y la Guerra de Corea (1931-1953), mediante la metodología interdisciplinar que proporcionan la his...

Educação escolar na primeira república: memória, história e perspectivas de pesquisa

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Alessandra Frota Martinez de Schueler

2009-01-01

Full Text Available O presente artigo desenvolve uma reflexão sobre a educação escolar, enfocando os debates, projetos e iniciativas voltadas para a disseminação da escola primária, no período da Primeira República (1889 a 1930, e problematizando a produção historiográfica sobre a educação republicana. Pretende-se contribuir para a abertura de um novo espectro de perguntas e problemas aos pesquisadores que se preocupam com a constituição da cultura escolar moderna e com os processos de socialização, transmissão, circulação, criação, apropriação e re (invenção culturais a partir da escola.

La integración en un sistema de bibliotecas de la Universidad de la República: una mirada desde las políticas educativas universitarias

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Isabel Madrid

2013-12-01

Full Text Available Se presenta una historia de los intentos de integración en un sistema de las bibliotecas de la Universidad de la República, con énfasis en el período que se inicia en 2003-2004, a partir de la conformación de la Subcomisión de Bibliotecas en el ámbito del Prorrectorado de Gestión Administrativa.Se intenta analizar el proceso en términos de políticas públicas de educación superior.

La cultura organizacional y la gestión del talento humano percibido por los trabajadores del Departamento de Comisiones del Congreso de la República

OpenAIRE

Ku Soria, Pamela Cinthya

2016-01-01

La investigación tuvo como objetivo general determinar la relación entre la cultura organizacional y la gestión del talento humano percibido por los trabajadores del Departamento de Comisiones del Congreso de la República del Perú. La investigación fue hipotética deductiva, descriptiva y correlacional, con diseño no experimental – transversal y enfoque cuantitativo. Se trabajó con una muestra de 132 trabajadores del Departamento de Comisiones de la institución. Para medir la...

La República, la Guerra Civil Española y su impacto en la colectividad española de Valparaíso

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Baldomero Estrada Turra

2013-07-01

Full Text Available Se analiza la evolución que tiene la colectividad española de Valparaíso durante la década de 1930 cuando España se ve afectada por la instauracion de la República y luego por la Guerra Civil. La ruptura que afectó a la comunidad española, como efecto de los acontecimientos de España, fue de una profundidad mayor que en otras ciudades del país y marcó su desarrollo institucional y comunitario por muchos años. Solo el paso de los años y los cambios generacionales permitieron superar las heridas del pasado.

Identification and synchronization of the common cosmic-ray signal in the IntCal13 14C calibration and the Greenland ice-core 10Be records

Science.gov (United States)

Muscheler, Raimund; Adolphi, Florian; Bronk Ramsey, Christopher; Rasmussen, Sune; Hughen, Konrad; Cooper, Alan; Turney, Chris

2017-04-01

The production rates of cosmogenic radionuclides (such as 10Be and 14C) are modulated by the solar and geomagnetic shielding of galactic cosmic rays. In addition, 14C and 10Be are influenced by the carbon cycle and the atmospheric transport and deposition, respectively. Isolating and identifying the common production signal allows us to synchronize ice core 10Be and tree ring 14C records during the Holocene (Adolphi and Muscheler, 2016), thereby connecting ice core climate records with 14C-dated records. Extending this comparison further back in time is challenging due to deteriorating quality of the 14C calibration record, IntCal13, (Reimer et al., 2013) and possible unidentified climate influences on the ice-core 10Be records. Nevertheless, by focusing on the most prominent production-rate features this comparison can be extended far back into the last glacial where, for example, the linkage of tree-ring based Kauri 14C data and the Greenland ice-core time scale (GICC05) suggested unresolved data and/or time scale differences around the period of the Laschamp geomagnetic field minimum at about 42000 yrs BP (Muscheler et al., 2014). Here we show that the data underlying the IntCal13 14C record and the ice-core 10Be records exhibit common variability that allows us to tentatively link the ice core GICC05 time scale to the radiocarbon time scale for almost the complete radiocarbon dating range. The observed time scale differences could be related to uncertainties in both the U/Th-based dating of the IntCal13 calibration data set and the GICC05 time scale, and we show that the two can be reconciled within the uncertainties of the ice-core layer counting. This direct comparison between IntCal13 and 10Be also suggests that the 14C differences shown in (Muscheler et al., 2014) around the Laschamp geomagnetic field minimum can be reduced by moderate adjustments to the GICC05 time scale. References: Adolphi, F., and Muscheler, R., 2016, Synchronizing the Greenland ice

Les revistes bilingües a la Tortosa de la II República

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M. Carme Gombau Domingo

2016-06-01

Full Text Available En l’àmbit de la premsa tortosina en català del primer terç del segle xx es donen dues actituds lingüístiques: la fabriana i la tortosinista. La primera, partidària del model de llengua de l’IEC, era minoritària als anys vint però es generalitza a partir dels anys trenta (La Veu de Tortosa, La Veu Comarcal, Ara, Acció, Vida Tortosina i Lluita; mentre que el tortosinisme, que es correspon amb una ideologia cada cop més localista i que eleva el «parlar tortosí» a la categoria de llengua, queda reduït durant la II República a tres revistes bilingües: La Zuda, Germanor i La Santa Cinta. There were two linguistic actitudes in the tortosine press of the first third in the 20th century: the fabriana amb the tortosinista. The fabriana, in favour of the IEC linguistic model, was in minority during the 20’s, but it became widespread from the 30’s (La Veu de Tortosa, La Veu Comarcal, Ara, Acció, Vida Tortosina i Lluita. The second, the tortosinista, had a local ideology and compared the tortosinisme talk as a complet language, but it was reduced during the ii Republic to three magazines: La Zuda, Germanor i La Santa Cinta.

Sistema de salud de República Dominicana The health system of Dominican Republic

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Magdalena Rathe

2011-01-01

Full Text Available En este trabajo se describen las condiciones de salud de la República Dominicana y, con mayor detalle, el sistema de salud dominicano, incluyendo su estructura y cobertura, sus fuentes de financiamiento, el gasto en salud, los recursos físicos, materiales y humanos de los que dispone, las tareas de rectoría que desarrolla el Ministerio de Salud Pública y la generación de información. También se discuten la participación de los usuarios en la operación y evaluación del sistema de salud y las más recientes innovaciones implementadas, dentro de las que destacan la nueva Ley General de Salud, la nueva Ley de Seguridad Social y el Plan Decenal de Salud.This paper describes the health conditions in Dominican Republic and the characteristics of the Dominican health system, including its structure and coverage, its financial sources, the health expenditure, the physical, material and human resources available, the stewardship functions developed by the Ministry of Public Health and the generation of health information. The participation of health care users in the operation and evaluation of the system and the most recent policy innovations, including the new General Health Law, the new Social Security Law and the Decennial Health Plan are also discussed.

Representações cômicas da República no contexto do Getulismo

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Elio Chaves Flores

2001-01-01

Full Text Available Neste artigo analiso as representações cômicas e discursivas da República e a trajetória política de Getúlio Vargas, a partir de uma narrativa que se assenta no método regressivo. Para isso, trabalhei com uma série de caricaturas publicadas em jornais e revistas na duração entre 1930 e 1954, confrontando a intertextualidade dessas imagens com alguns discursos satíricos e irônicos produzidos por memorialistas. Procuro demonstrar que há semelhança entre a inversão humorística e a textualidade da memória, quando inventam a respeito de seu tempo e dos outros imagens verossímeis.This article analyses the comic and discursive representations of the Brazilian Republic and Getúlio Vargas’ political career, starting from a narrative constructed in the regressive method. For that, I worked with a series of cartoons published in newspapers and magazines in the span of time between 1954 and 1930, matching the intertextuality of these images with some of the satiric and ironic speeches produced by witnesses. It is demonstrated there is likeness between the comic inversion and the textuality of the memory, when they invent concerning their time and other ones, the verisimilitude of the images.

L’intérêt historiographique des manuscrits de travail de linguistes : l’exemple de la linguistique générale de Joseph Vendryes

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Testenoire Pierre-Yves

2016-01-01

Full Text Available Dans quelle mesure les manuscrits de travail des linguistes présentent-ils un intérêt pour les historiens de la linguistique ? Ce type de documents suscite, depuis quelques années, un regain indéniable de curiosité. L’exploration d’un nombre croissant de fonds d’archives de savants permet, au-delà d’un élargissement de l’horizon documentaire, d’envisager des approches comparatives entre différentes pratiques savantes. Elle ouvre aussi de nouvelles interrogations. Cet article réfléchit à l’intérêt historiographique de ce type de documents à partir d’un cas inédit : les papiers de travail consacrés à la linguistique générale du linguiste français, Joseph Vendryes (1875-1960. On met en évidence le double intérêt des archives privées de savants : documentaire et processuel. On aborde, dans un premier temps, les manuscrits d’un point de vue documentaire de façon à dégager ce que leur prise en compte modifie de notre connaissance de la linguistique générale de Joseph Vendryes. Le deuxième temps, consacré à la perspective processuelle, fait des manuscrits le lieu de l’observation de la méthode. Il s’agit d’analyser, à partir des manuscrits préparatoires à l’écriture d’un article, comment s’élabore un discours scientifique à caractère général sur le langage et les langues. Ces archives privées sont au carrefour de questionnements de recherche qui relèvent aussi bien d’une histoire conceptuelle que d’une histoire sociale des sciences du langage.

Recursos administrativos en materia de propiedad industrial en la República Argentina, 2001 - 2012 : análisis estadístico, encuadre legal y criterios de resolución

OpenAIRE

Siniscalchi, Mariana

2014-01-01

La presente tesis por objetivo analizar las particularidades de los recursos administrativos interpuestos entre los años 2001 y 2012 contra actos dictados por el Instituto Nacional de la Propiedad Industrial (INPI) de la República Argentina en solicitudes de derechos de propiedad industrial: marcas, patentes de invención, modelos de utilidad, modelos y diseños industriales; y en solicitudes de registro de contratos de transferencia de tecnología.

La "república posible" y sus problemas en Argentina: Normalistas e industriales debaten el plan educativo alberdiano de las dos gestiones presidenciales de Julio Argentino Roca (1880-1886 y 1898-1901 The "Possible Republic" and its Problems in Argentina: Student Teachers and Industrialists Debate the Alberdian Educational Plan of the Two Administrations of President Julio Argentino Roca (1880-1886 and 1898-1901

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Alejandro Herrero

2011-08-01

Full Text Available Julio Argentino Roca, en sus dos presidencias a fines del siglo XIX, se adhiere al programa alberdiano de la república posible en Argentina. Intenta cambiar el sistema educativo que se opone a la república de habitantes productores de riqueza y, finalmente, se encuentra con algo peor: no sólo fracasa en este intento, sino que advierte en la misma contienda verbal que el mismo programa de la república posible es cuestionado por diferentes actores. En este artículo se estudia, como una primera aproximación al tema, a los normalistas y a los industriales, ya que parte del normalismo y de la corporación industrial apoyan decididamente la propuesta educativa alberdiana de Roca, sin embargo, cuestionan la república posible y manifiestan que se debe avanzar hacia una república de ciudadanos.During his two administrations in the late 19th century, Julio Argentino Roca adhered to Alberdi's program of the possible republic in Argentina. He attempted to change the education system that opposed the republic of inhabitants that created wealth and eventually discovered something worse: not only did he fail in this attempt, but he noticed, during the same verbal competition, that the program of the possible republic was questioned by different actors. As an initial approach to the topic, this article examines student teachers and industrialists, since a section of student teachers and the industrial Corporation determinedly supported Rocas Alberdian educational proposal. Nevertheless, they questioned the possible republic, adding that it should advance towards a republic of citizens.

Transpondo muros: Escritas da violência na República Democrática Alemã

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Elcio Loureiro Cornelsen

2009-06-01

Full Text Available O objetivo do presente artigo é esboçar, a partir da interpretação das obras “Zeit-Zeugen”. Inhaftiert in Berlin-Hohenschönhausen (1996, organizada por Gabriele Camphausen, Folterzelle 36 Berlin-Pankow. Erlebnisbericht einer Stasihaft (1993, de Timo Zilli, Ein guter Kampf. Fakten, Daten, Erinnerungen 1945-1954 (1998 do político Ewald Ernst, Die Stasi war mein Eckermann: oder mein Leben mit der Wanze (1991, do escritor Erich Loest, e Geboren am 13. August. Der Sozialismus und ich (2004, do jornalista Jens Bisky, um breve estudo sobre as diversas formas e fases da violência enquanto instrumento de poder, praticada pelo Estado do SED na República Democrática Alemã nos 40 anos de sua existência, e discutir especialmente alguns aspectos teóricos sobre o conceito de “literatura de testemunho”. Os cinco relatos analisados, de caráter memorialista e autobiográfico, se pautam por um tom decididamente crítico frente aos desmandos num Estado totalitário. “Transpor muros” nos 20 anos após a Queda do Muro de Berlim, desse ponto de vista, implica um olhar memorialista de denúncia contra o esquecimento frente a um passado traumático.

“La República de los Sueños”: De lo racional de la República a lo irracional de los sueños

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Broullón Acuña, Esmeralda

2010-02-01

Full Text Available The Republic of the dreams is an “Atlantic novel” and as such it develops a narrative on the trip and the memory of a family of Spanish origin in the contemporary Brazil. The work investigates the process of immigration and adjustment of a Galician patriarchal and capitalist, predestined to the social success. A consecration that will go up to his last consequences, coming back to his village, of which went out in 1913, to marry the daughter of a nobleman. Founder of a lineage hispanic-brazilian will remain caught in the profit that he itself interweaves on having taken part of the networks and the oligarchic practices that dominate in the country. Thus the authoress re-composes a statement ethnic-historical where she represents the ethnic segmentation of the condition state-nation and institutes the memory and the culture as elements of resistance.

La República de los sueños es una “novela atlántica” y como tal desarrolla una narrativa sobre el viaje y la memoria de una familia de origen español en el Brasil contemporáneo. La obra indaga el proceso de inmigración y adaptación de un gallego patriarcal y capitalista, predestinado al éxito social. Una consagración que llevará hasta sus últimas consecuencias, retornando a su aldea, de la cual salió en 1913, para casarse con la hija de un hidalgo. Fundador de un linaje hispanobrasileño quedará atrapado en el lucro que él mismo entreteje al participar de las redes y las prácticas oligárquicas que dominan en el país. De este modo la autora recompone un relato etnohistórico donde representa la segmentación étnica del estado-nación e instituye la memoria y la cultura como elementos de resistencia.

Adjuvant therapy for gastric cancer: what have we learned since INT0116?

Science.gov (United States)

Jácome, Alexandre A; Sankarankutty, Ajith K; dos Santos, José Sebastião

2015-04-07

Gastric cancer is one of the main cancer-related causes of death worldwide. The curative treatment of gastric cancer consists of tumor resection and lymphadenectomy. However, surgical treatment alone is associated with high recurrence rates. Adjuvant treatment strategies have been studied over the last decades, but there have been controversial results from the initial studies. The pivotal INT0116 study demonstrated that the use of adjuvant chemoradiotherapy with 5-fluorouracil increases relapse-free and overall survival, and it has been adopted across the Western world. The high toxicity of radiochemotherapy and suboptimal surgical treatment employed, with fewer than 10% of the patients submitted to D2 lymphadenectomy, were the main study limitations. Since its publication, other adjuvant treatment modalities have been studied, and radiochemotherapy is being refined to improve its efficacy and safety. A multimodal approach has been demonstrated to significantly increase relapse-free and overall survival, and it can be offered in the form of perioperative chemotherapy, adjuvant chemoradiotherapy or adjuvant chemotherapy, regardless of the extent of lymphadenectomy. The objective of the present review is to report the major advances obtained in the last decades in the adjuvant treatment of gastric cancer as well as the perspectives of treatment based on recent knowledge of the molecular biology of the disease.

High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap.

Science.gov (United States)

Conway, J E; Rhys, C M; Zolotukhin, I; Zolotukhin, S; Muzyczka, N; Hayward, G S; Byrne, B J

1999-06-01

Recombinant adeno-associated virus type 2 (rAAV) vectors have recently been used to achieve long-term, high level transduction in vivo. Further development of rAAV vectors for clinical use requires significant technological improvements in large-scale vector production. In order to facilitate the production of rAAV vectors, a recombinant herpes simplex virus type I vector (rHSV-1) which does not produce ICP27, has been engineered to express the AAV-2 rep and cap genes. The optimal dose of this vector, d27.1-rc, for AAV production has been determined and results in a yield of 380 expression units (EU) of AAV-GFP produced from 293 cells following transfection with AAV-GFP plasmid DNA. In addition, d27.1-rc was also efficient at producing rAAV from cell lines that have an integrated AAV-GFP provirus. Up to 480 EU/cell of AAV-GFP could be produced from the cell line GFP-92, a proviral, 293 derived cell line. Effective amplification of rAAV vectors introduced into 293 cells by infection was also demonstrated. Passage of rAAV with d27. 1-rc results in up to 200-fold amplification of AAV-GFP with each passage after coinfection of the vectors. Efficient, large-scale production (>109 cells) of AAV-GFP from a proviral cell line was also achieved and these stocks were free of replication-competent AAV. The described rHSV-1 vector provides a novel, simple and flexible way to introduce the AAV-2 rep and cap genes and helper virus functions required to produce high-titer rAAV preparations from any rAAV proviral construct. The efficiency and potential for scalable delivery of d27.1-rc to producer cell cultures should facilitate the production of sufficient quantities of rAAV vectors for clinical application.

Sujet de droit et sujet d’intérêt : Montesquieu lu par Foucault

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Céline Spector

2007-04-01

Full Text Available Dans les cours au Collège de France réunis dans Naissance de la biopolitique, Foucault soutient qu’une science économico-juridique est rigoureusement impossible. Or cette thèse radicale mérite discussion, à partir d’un auteur trop souvent ignoré des historiens de la genèse de l’économie politique. Montesquieu, à sa façon, contribue à la constitution de ce savoir économico-juridique, susceptible de penser ensemble sujet d’intérêt et sujet de droit. L’esprit de cette étude ne sera pas de critiquer Foucault en montrant que Montesquieu ne « rentre » pas dans l’opposition de ses paradigmes, mais plutôt de tenter de mesurer l’originalité d’une pensée qui conçoit des échanges entre propriété et liberté qui ont pour effet d’unifier rationalité économique et rationalité juridique.

Maquiavel e a República: lei, governo legal e institucionalidade política nos Discursos sobre a primeira década de Tito Lívio

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Raquel Kritsch

2010-10-01

Full Text Available

O objetivo deste artigo é introduzir o leitor no pensamento político de Nicolau Maquiavel em seu Discursos sobre a primeira década de Tito Lívio, procurando mostrar a riqueza e diversidade do pensador florentino quando se interroga sobre questões que dizem respeito às leis, à liberdade, às instituições políticas e seu funcionamento numa república, e outros tantos temas raramente associados ao seu nome. O intuito aqui é apresentar algumas das noções centrais do “Maquiavel republicano”, para quem a virtù, na república, é também um atributo do povo (e não apenas do príncipe, como se lê em seu célebre tratado sobre o principado. Explorar aspectos pouco divulgados e debatidos do pensamento político de Maquiavel — especialmente quando se compara com a profusão de escritos a respeito do célebre “Maquiavel monarquista” — bem como de sua teoria da res publicaserá, portanto, a tarefa a ser levada a cabo neste texto introdutório.

Galeguismo, agro e agrarismo na Galicia da II República

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Cabo Villaverde, Miguel

2009-12-01

Full Text Available The Partido Galeguista (PG was created in December 1931 as the expression of Galician nationalism during the Second Republic (1931-1936. Prior to that, the Galician nationalists had been very influential in the cultural sphere but rather powerless from a political point of view. The PG regarded agriculture and peasantry as a priority, not only because of their objective importance in the Galician economy and society in the 1930s but also because they were seen as the bulwarks of the national identity. In fact, the characteristics, needs and paths of development of the Galician agrarian sector were usually defined as opposed to those of the rest of Spain. It is then understable that the PG tried to win the agrarian unions over, and that it is arguable that it had plenty of common features with the so-called Agrarian Parties in other European regions.

O Partido Galeguista (PG foi creado en decembro de 1931 como expresión do nacionalismo galego durante a Segunda República (1931-1936. Con anterioridade, os nacionalistas galegos foron moi influíntes no eido cultural pero maiormente inoperantes dende o punto de vista político. O PG consideraba a agricultura e o campesiñado como unha prioridade, non só pola súa importancia obxectiva na economía e sociedade galegas dos anos trinta senón tamén porque eran vistos como os baluartes da identidade nacional. De feito, as características, necesidades e vías de desenvolvemento do sector agrario galego eran normalmente definidas en oposición ás do resto de España. É daquela comprensible que o PG tentase gañarse ás sociedades agrarias, e mesmo se pode afirmar que tiña moitos puntos en común cos chamados Partidos Agrarios doutras rexións europeas.

L'intégration des TIC dans un environnement éducatif conditionné par le système du 'spoon-feeding.'

OpenAIRE

Saurty , Krishnah Moortee

2013-01-01

Cet article prend son essence dans un projet pédagogique dont la préoccupation est de renforcer les savoirs notamment à travers le concept d'apprentissage intégrant les Technologies de l'Information et de la Communication (Tic) afin de développer des actions éducatives pouvant apporter des réponses réelles aux principes du 'spoon-feeding', véritable pilier du système éducatif mauricien s'appuyant sur le contenu du savoir disciplinaire et conditionnant l'apprenant dans sa capacité à développer...

Pluralismo epistémico y pluralismo político: La gestión de la república

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Ricardo Enrique Schmukler

2017-02-01

Full Text Available En los últimos años, la noción de gestión pública ha desplazado a la de administración pública en la ponderación colectiva de la eficacia y la eficiencia gubernamental y administrativa. El presente trabajo discute este concepto, entendiéndolo como unidad de la teoría y la práctica en el ejercicio de los poderes y derechos públicos. Se argumenta acerca de la congruencia entre las formas del pluralismo que proponen las teorías constructivas y discursivas, tanto en el orden del conocimiento como en el de la organización. Así, se sostiene que, trascendiendo los límites del entendimiento convencional, el pluralismo epistémico y  el pluralismo político resultan manifestaciones de un mismo operar, en distintos campos de la experiencia, como formas del pensamiento y la acción congruentes con los valores socialmente dispuestos para regir una sana administración de la república.

Populational survey of arthropods on transgenic common bean expressing the rep gene from Bean golden mosaic virus.

Science.gov (United States)

Pinheiro, Patrícia V; Quintela, Eliane D; Junqueira, Ana Maria R; Aragão, Francisco J L; Faria, Josias C

2014-01-01

Genetically modified (GM) crops is considered the fastest adopted crop technology in the history of modern agriculture. However, possible undesirable and unintended effects must be considered during the research steps toward development of a commercial product. In this report we evaluated effects of a common bean virus resistant line on arthropod populations, considered as non-target organisms. This GM bean line (named M1/4) was modified for resistance against Bean golden mosaic virus (BGMV) by expressing a mutated REP protein, which is essential for virus replication. Biosafety studies were performed for a period of three years under field conditions. The abundance of some species was significantly higher in specific treatments in a particular year, but not consistently different in other years. A regular pattern was not observed in the distribution of insects between genetically modified and conventional treatments. Data analyses showed that minor differences observed can be attributed to random variation and were not consistent enough to conclude that the treatments were different. Therefore the present study indicates that the relative abundance of species are similar in transgenic and non-transgenic fields.

AC and dielectric properties of vacuum evaporated InTe bilayer thin films

Energy Technology Data Exchange (ETDEWEB)

Matheswaran, P. [PG and Research, Department of Physics, Kongunadu Arts and Science College (Autonomous), GN Mills (po), Coimbatore 641 029, Tamil Nadu (India); Sathyamoorthy, R., E-mail: rsathya59@gmail.com [PG and Research, Department of Physics, Kongunadu Arts and Science College (Autonomous), GN Mills (po), Coimbatore 641 029, Tamil Nadu (India); Saravanakumar, R. [PG and Research, Department of Physics, Kongunadu Arts and Science College (Autonomous), GN Mills (po), Coimbatore 641 029, Tamil Nadu (India); Velumani, S. [Department of Electrical Engineering (SEES), CINVESTAV-IPN Zacatenco, D.F., 07360 (Mexico)

2010-10-25

III-VI compound semiconductors receive great attention due to its applications in memory devices, switching devices, gas sensors, hybrid solar cells, etc. InTe thin films were prepared by sequential thermal evaporation of In and Te at Ar atmosphere. X-ray diffraction pattern of the films shows that the films posses mixed phase of In{sub 2}Te{sub 3} and In{sub 2}Te{sub 5}. Grain size (D) and dislocation density were calculated by using Scherer's formula. Surface morphology of the film is analyzed by SEM and the surface is found to be agglomeration of well defined grains. EDS analysis reveals that elemental composition is in right stoichiometry. The value of capacitance and tan {delta} was recorded with respect to different frequencies and at different temperatures. It is observed that the capacitance decreases with increase in frequency at all temperatures. The observed nature of the capacitance is due to the inability of the dipoles to orient in a rapidly varying electric field. The pronounced increase in capacitance toward the low frequency region may be attributed to the blocking of charge carriers at the electrodes which leads to space charge layer resulting in the increase of capacitance. The mechanism responsible for AC conduction is found to be electronic hopping. TCC and TCP values were calculated and the results are discussed.

Nuevos registros de hongos entomopatógenos en acridios (Orthoptera: Acridoidea de la República Argentina

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Sebastian A. PELIZZA

2010-01-01

Full Text Available Los acridios (tucuras y langostas continúan ocasionando pérdidas económicas en la agricultura a nivel mundial. En Argentina, la importancia de estos insectos ha sido reconocida desde mediados del siglo XIX, dependiendo de la región considerada y en relación al progresivo desarrollo agropecuario en el país. Los hongos son los microorganismos parásitos de insectos más frecuentemente encontrados en la naturaleza y la mayoría de las investigaciones con hongos entomopatógenos se ha centrado en su desarrollo como bioplaguicidas. En el presente trabajo se dan a conocer cinco registros nuevos de Beauveria bassiana (Bals.-Criv. Vuill., y dos de Entomophaga grylli (Fresen. A. Batko que se encontraron afectando distintas especies de acridios; se amplía así la distribución geográfica y el espectro hospedador para estas especies fúngicas. Cabe destacar que con el aporte de estos siete registros nuevos, el número total de hongos entomopatógenos de acridios citados para la República Argentina se eleva de 22 a 29.

O assassinato de um homossexual diante de um tribunal da Capital da República em meados do século XX

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Rivail Carvalho Rolim

2013-05-01

Full Text Available http://dx.doi.org/10.1590/S0104-026X2013000100017 O objetivo deste artigo é o de analisar como o assassinato de um homossexual foitratado em um tribunal da Capital da República em meados do século XX. Os autos criminaispodem revelar aspectos significativos sobre a aplicação do direito nas instâncias judiciais.Ressaltamos como a cultura jurídico-penal no país continuou reproduzindo os mesmos padrõessocioculturais das culturas jurídico-penais ocidentais; em última instância, condenando o prazerou pelo menos determinadas formas de senti-lo. Da mesma forma, inferimos que, por intermédioda legalidade processual, se reprimiu determinado comportamento sexual, já que a legalidadeformal não preceituava a homossexualidade como crime.

Legislative Districts, Four layers - One State Assembly district, one State Senate district, one US House of Rep district, and one US Senate district showing the locations in the County of Polk, WI., Published in 2007, 1:24000 (1in=2000ft) scale, Polk County Government.

Data.gov (United States)

NSGIC Local Govt | GIS Inventory — Legislative Districts dataset current as of 2007. Four layers - One State Assembly district, one State Senate district, one US House of Rep district, and one US...

Desarrollo de un entorno de programación para un robot simulado Turtlebot-2 con brazo manipulador WIDOWX mediante la conexión V-REP y MATLAB

OpenAIRE

Fernández-Vega, Iván

2016-01-01

El objetivo principal de este Trabajo de Fin de Grado ha sido el de implementar un entorno de programación para un robot móvil Turtlebot-2 dotado de un brazo articulado WidowX. Para ello, se ha modelado este conjunto robótico en el simulador V-REP a partir de las descripciones físicas de los mismos, y se han ajustado diversos parámetros para que el comportamiento del robot simulado sea lo más parecido al del robot real. Para implementar las aplicaciones que controlen nuestro co...

Impacto económico del turismo de crucero: caso República Dominicana

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José Alberto Acosta Guzmán

2017-01-01

Full Text Available Debido al rápido crecimiento de la actividad turística en el segmento del turismo de cruceros en el mundo actual, gobiernos y actores involucrados en esta clasificación especial del turismo, han observado la necesidad de conocer de forma más profunda la magnitud del impacto económico, que la industria del crucero produce en los diferentes destinos turísticos. Además, entender en particular, cómo los cruceristas gastan su dinero durante su estadía, es una información esencial para los diferentes actores involucrados en la gestión, crecimiento y desarrollo de esta actividad turística. La presente investigación tiene como propósito analizar el impacto económico del turismo de crucero en la República Dominicana. Cuando se habla de turismo de cruceros, no sólo se hace referencia a la embarcación y a los puertos-destino, sino a una compleja red en donde actúan múltiples factores que directa o indirectamente hacen de este producto turístico uno de los más importantes. Se considera la Encuesta de Gasto y Opinión a Pasajeros de Cruceros sobre el consumo que realizan los turistas de cruceros en su estadía en el país, tomando en cuenta los productos que adquieren como unidad económica de consumo, es decir, bienes y servicios inherentes al propio viaje como comidas, bebidas, entretenimientos, transporte local, tours, entre otros gastos, se excluye el alojamiento, así como las compras para fines comerciales.

Política y Administración Provincial. La Diputación de Sevilla durante la Dictadura de Primo de Rivera y la II República (1923-1936).

OpenAIRE

Ponce Alberca, Julio

2016-01-01

Desde la perspectiva de fines del siglo XX, los regímenes políticos de la España de los años veinte y treinta aparecen como una secuencia de ensayos en respuesta a la profunda crisis sufrida por el sistema de la Restauración (1876-1923). Bajo ese enfoque, la Segunda República (1931-1936) se nos muestra inscrita en el esfuerzo por encontrar una nueva alternativa tras el fracaso de la Dictadura primorriverista (1923-1930) y las dictablandas del genera...

Enseñar a traducir: metodología en la formación de traductores e intérpretes

OpenAIRE

Santos, Silvana Aguiar dos; Neckel, Filipe

2014-01-01

Amparo Hurtado Albir lançou em 1999 o livro Enseñar a traducir: metodología en la formación de traductores e intérpretes oferecendo uma proposta teórica e metodológica para a formação desses profissionais. O marco teórico que norteia o livro é a noção de competência tradutória e a sua aquisição, assim como, o marco metodológico é embasado na noção de “formação por objetivos e competências” afiliando-se a abordagem por “tarefas de tradução”.

Characterization of Multidrug Resistant ESBL-Producing Escherichia coli Isolates from Hospitals in Malaysia

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King-Ting Lim

2009-01-01

Full Text Available The emergence of Escherichia coli that produce extended spectrum β-lactamases (ESBLs and are multidrug resistant (MDR poses antibiotic management problems. Forty-seven E. coli isolates from various public hospitals in Malaysia were studied. All isolates were sensitive to imipenem whereas 36 were MDR (resistant to 2 or more classes of antibiotics. PCR detection using gene-specific primers showed that 87.5% of the ESBL-producing E. coli harbored the blaTEM gene. Other ESBL-encoding genes detected were blaOXA, blaSHV, and blaCTX-M. Integron-encoded integrases were detected in 55.3% of isolates, with class 1 integron-encoded intI1 integrase being the majority. Amplification and sequence analysis of the 5′CS region of the integrons showed known antibiotic resistance-encoding gene cassettes of various sizes that were inserted within the respective integrons. Conjugation and transformation experiments indicated that some of the antibiotic resistance genes were likely plasmid-encoded and transmissible. All 47 isolates were subtyped by PFGE and PCR-based fingerprinting using random amplified polymorphic DNA (RAPD, repetitive extragenic palindromes (REPs, and enterobacterial repetitive intergenic consensus (ERIC. These isolates were very diverse and heterogeneous. PFGE, ERIC, and REP-PCR methods were more discriminative than RAPD in subtyping the E. coli isolates.

Contribuciones de la Inspección de primera enseñanza a la estructura pedagógico-educativa de la Segunda República española

OpenAIRE

Jiménez Eguizábal, J. Alfredo

2017-01-01

1. Introducción La Segunda República, a juzgar por la corriente de estudios de que es objeto en la actualidad, se revela como un ciclo sumamente fecundo para la sociedad española y, particularmente, para el corpus pedagógico en general por el relieve que la educación adquiere dentro del sistema social, político e, incluso, económico. La comunicación que presentamos aborda un capítulo, a nuestro modo de ver, importante y significativo, al que hasta ahora no se le había prestado la debida atenc...

Intégration des pluies prévues du système AROME-PI dans le système AIGA

OpenAIRE

Demargne, J.; Javelle, P.

2015-01-01

/ Cette étude a été réalisée pour le SCHAPI (Service Central d'Hydrométéorologie et d'Appui à la Prévision des Inondations) pour analyser l'amélioration du système d'avertissement sur la possibilité de crues rapides AIGA en intégrant des prévisions de pluie future à courte échéance et fine résolution spatio-temporelle et en prenant en compte leurs incertitudes. Le SCHAPI développe actuellement un service d'avertissement automatisé valable sur l'ensemble de la France, qui sera complété par un ...

tavgM_2d_int_Nx: MERRA 2D IAU Diagnostic, Vertical Integrals and Budget Terms, Monthly Mean 0.667 x 0.5 degree V5.2.0 (MATMNXINT) at GES DISC

Data.gov (United States)

National Aeronautics and Space Administration — The MATMNXINT or tavgM_2d_int_Nx data product is the MERRA Data Assimilation System 2-Dimensional vertical integral that is time averaged single-level at the native...

Aulas de ciências para surdos: estudos sobre a produção do discurso de intérpretes de LIBRAS e professores de ciências

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Walquíria Dutra de Oliveira

2015-06-01

Full Text Available O bilinguismo na educação de surdos pressupõe a língua de sinais como primeira língua do surdo e, com a inclusão escolar, os alunos surdos foram inseridos em instituições regulares de ensino, implicando uma nova estrutura da sala de aula. O ensino de ciências para surdos é um desafio, pois o aluno surdo utiliza uma língua diferente da do professor, e necessita de um intérprete de LIBRAS para ter acesso ao corpo de conhecimentos mediados por ele. A investigação objetivou analisar a produção de narrativas (um gênero do discurso de professores e intérpretes de LIBRAS sobre a aula de ciências para surdos. As narrativas foram produzidas no “diário de aula”, e foram analisadas pela técnica de análise de conteúdo. Nossos resultados apontam que o bilinguismo ainda não permeia a sala de aula inclusiva, e que a barreira linguística é a maior dificuldade encontrada no aprendizado dos conhecimentos científicos pelos alunos surdos.

Instituições e cooperação social em Douglass North e nos intérpretes weberianos do atraso brasileiro

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Hélio Afonso de Aguilar Filho

2011-09-01

Full Text Available O artigo tem por objetivo resgatar a aproximação teórica entre o arcabouço institucionalista de Douglass North e os argumentos utilizados por intérpretes do Brasil de reconhecida orientação weberiana, como Sérgio Buarque de Holanda, Vianna Moog e Raymundo Faoro. Para tanto, privilegia o entendimento da relação entre instituições e cooperação social presentes na obra desses autores como variável relevante para explicar o desempenho de longo prazo da economia brasileira, bem como de seu relativo atraso.

Etude Théorique et Numérique d’une Méthode de Point Intérieur pour la Résolution du Problème d’Inégalités Variationnelles

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H GRAR

2007-12-01

Full Text Available Dans ce travail, nous présentons une nouvelle alternative de type point intérieur pour résoudre le problème d’inégalités variationnelles noté (VIP. Ce dernier connu par son importance grandissante aussi bien sur le plan théorique que pratique, est malheureusement traité par des méthodes non pratiques (hypothèses trop restrictives, calcul pénalisant des projections. L’idée de progresser à l’intérieur du domaine des contraintes est à fait attrayante, car une fois mise au point elle élimine tous les handicapes algorithmiques ou presque. Cette idée est aussi motivée par le succès remarquable des techniques de point intérieur au niveau de la programmation mathématique en général. Nous avons pu mettre en oeuvre plusieurs versions de l’algorithme issues d’une étude théorique approfondie dûe à Censor et al. [1998] et comprenant nos propres aménagements. Au cours de l’implémentation numérique, on a fait intervenir des problèmes mathématiques très importants. Les résultats obtenus sont très encourageants. Ils sont présentés dans un cadre comparatif signifiant.

S’exercer à l’empathie : une expérience pédagogique en design d’intérieur

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Rabah Bousbaci

2010-11-01

Full Text Available All professions have obligations to the public they serve, i.e.: the patient for physicians, psychoa- nalysts, or nurses; the client for lawyers; the consumer for managers; etc. The user or occupant of the built environment is the intended public of interior design services. How do interior design students learn to imagine the occupants of the built environments they design? The concept of empathy, commonly defined as the capacity of identification with and understanding of another’s situation, feelings, and motives, is particularly suitable to explore this attitude. This paper has two parts. The first one presents an interior design academic exercise where students learn to imagine the occupants of their design project by using a methodological tool called an “ethical compass”. The compass is composed of three poles, which remind the three fundamental rela- tions in the human condition as they were considered in the Stoic tradition: man’s relation to oneself, to others, and to nature. In the second part, the paper outlines several theoretical elements, which help to understand, to strengthen, and eventually to make progress about some of the conceptual bases that underline this approach. Mainly, it outlines important ethical theories and specific approaches to the concept of empathy.RÉSUMÉLes professionnels ont par définition un public bénéficiaire de leurs services : le patient pour le médecin, le psychologue ou l’infirmière ; le client pour l’avocat ; le consommateur pour le ges- tionnaire d’une entreprise commerciale ; etc. L’usager ou l’habitant du cadre bâti constitue un des destinataires des services professionnels du designer d’intérieur. De quelle manière peut-on apprendre aux étudiants/futurs professionnels du design d’intérieur à se mettre à la place de l’usager/habitant des espaces qu’ils conçoivent ? Le concept de l’empathie, communément décrit comme la capacité de se mettre à la place

Leptospirosis porcina: prevalencia serológica en establecimientos productores de la República Argentina

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Jessica Petrakovsky M.

2013-03-01

Full Text Available Objetivo. Detectar la presencia de anticuerpos contra Leptospira sp en cerdos que no presentaban sintomatología clínica, pertenecientes a establecimientos de producción porcina ubicados en todo el territorio de la República Argentina. Materiales y métodos. La asignación de predios y muestras se realizó en forma proporcional a los registrados en cada provincia a lo largo de todo el país. En total se estudiaron 1.524 predios, de los cuales se tomaron 19.872 muestras de suero y en la primera etapa se procesaron 3.631 de los mismos. Este estudio toma en consideración zonas identificadas por provincia, municipio y predios. Los sueros fueron analizados por la técnica de MAT (prueba de microaglutinación. Resultados. El 30% de las muestras resultaron positivas a la prueba tamiz empleada (primera etapa del MAT. La mayoría presentó coaglutininas a dos o a tres serovariedades. Al realizar la titulación de los sueros (segunda etapa del MAT, el porcentaje de positividad se mantuvo, siendo los serovares de mayor prevalencia Castellonis e Icterohaemorrhagiae. El 90% de las muestras presentó un título final de 1:200. Conclusiones. La existencia de sueros positivos en todas las provincias indica el contacto de los animales con la leptospira a lo largo de todo el país.

Stage de médecine générale en Mauritanie : intérêts dans la formation médicale initiale

OpenAIRE

Gaucher , Marie-Laure

2012-01-01

Non disponible / Not available; Les voyages, l'immigration multiplient les situations cliniques et modifient l'épidémiologie des pathologies rencontrées en soins primaires. La formation universitaire doit sensibiliser les futurs praticiens à cette dimension internationale de la santé tout en leur permettant d'acquérir un certain nombre de compétences.Les données de la littérature ont montré que de nombreuses universités ont intégré dans leurs programmes de formation des stages pratiques à l'é...

El papel de los intelectuales en la gestación de la II República Española : intelectuales socialistas, trayectoria y actuación para la consecución del triunfo electoral del PSOE en el primer Bienio Republicano

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María Cruz Galindo

2005-01-01

Full Text Available La II República Española ha sido uno de los acontecimientos de mayor relevancia del siglo xx por las consecuencias políticas, sociales y económicas que trajo consigo y que estuvieron siempre orientadas al cambio y modernización de España. El proyecto republicano que se inauguró en 1931 fue la culminación de toda una serie de anhelos que venían gestándose desde mucho tiempo atrás por parte de distintos grupos políticos y sociales, pero también por parte de un importante sector cultural: los intelectuales, quienes desempeñaron una labor decisiva en la gestación y configuración de la II República, hasta tal punto que, en no pocas ocasiones, este régimen ha sido denominado como la «república de los intelectuales».The Spanish Second Republic has been one of the most relevant events of the XXth century because of the political, social and economic consequences which it brought and that were always thought to the change and modernization of Spain. The republican project that was opened in 1931 was the end of a series of wishes that were developing for a long time by different political and social groups, but also by an important cultural sector: the intelectuals, who carried out a decisive task in the preparation and configuration of the Second Republic, so that on several occasions this regime has been named as the «Intelectuals’ Republic». The communication «The role of the intelectuals in the origins of the Second Spanish Republic.

Desdobramentos foucaultianos sobre a relação de ensino do intérprete de língua de sinais educacional

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Vanessa Regina de Oliveira Martins

2017-01-01

Full Text Available o presente trabalho, tem como objetivo discutir e analisar trajetórias, atuações e relações de ensino em que temos presente a figura do intérprete de língua de sinais educacional incluído na dinâmica escolar: sua emergência na escola, os discursos sobre sua função e as práticas decorrentes de sua atuação tradutória cotidiana - as implicações que há no ensino de surdos, os modos como se entende tal função. A tese tem como objetivo teorízar e afirmar pelo menos três modos de mestria presentes em variadas salas de aula, especificamente nas que contam com a presença de pessoas surdas e de intérpretes de língua de sinais educacional. Os modos são os seguintes: o mestre explicador, o revelador e o emissor de signos. Em cada análise, faço um aprofundamento das possíveis relações interpessoais entre os sujeitos em dada cena, sendo, portanto, relações de docência a partir dessas proposições. O olhar se dá nos espaços propostos e configurados a partir de uma relação docente, e com isso, as análises realizadas passam pelo olhar conceitual de Michel Foucault, tendo como marca as relações de subjetividades no ocidente. Para tal empreitada, buscaram-se, nos estudos foucaultianos os tipos de mestria possíveis, apresentados pelo autor na obra A hermenêutica do sujeito. Isso se fez para afirmar a necessidade de um retorno a uma relação antiga de ensino: um mestre que se ocupa com o processo e não com o yroduto; uma mestria que se faz não pela condução ao modelo, mas na presença do "estar com o outro". Assim, conceitos de Gilles Deleuze e Michel Foucault são trazidos e combinados entre si para complementar o que se afirma como mestria ativa, ou seja, uma posição-mestre, que possibilita efeito de relações parresiásticas de ensino. A posição-mestre será baliza da pela relação conceitual existente entre ela e a função-educador - conceito desenvolvido na tese de doutoramento de Carvalho (2008. Nesse

O Deus do progresso: a difusão do cientificismo no movimento operário gaúcho da I República

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Benito Bisso Schmidt

2001-01-01

Full Text Available O objetivo do artigo é examinar a difusão de teorias cientificistas no movimento operário gaúcho no período da I República, tais como o positivismo, o darwinismo, a antropologia criminal, o espiritismo kardecista, etc.; bem como os canais de difusão de tais idéias e suas repercussões políticas, sobretudo a conformação de um "estilo autoritário" na condução das lutas operárias.This article aims at examining the diffusion of scientism theories in the gaúcho working movement in the 1st Republic, such as darwinism, criminal anthropology, the kardecist spiritism etc.; as well as the channels of diffusion of such ideas and its political repercution, above all else the conformation of an "authoritarian style" in the conduction of the working struggle.

Políticas comunicacionales, representaciones mediáticas y legitimidad judicial. Un estudio de caso sobre la Corte Suprema de la República Argentina

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Valentín Thury Cornejo

2010-05-01

Full Text Available El presente trabajo analiza el complejo rol que los medios de comunicación asumen en la conformación dela imagen de los tribunales de justicia y, mediatamente, en su legitimidad. A partir de un estudio de caso sobre la Corte Suprema de la República Argentina, se intentan identificar los mecanismos culturales que entran en juego en la construcción de los imaginarios sociales respecto de la actuación de la Justicia. Para ello, se analiza el discurso de los tres principales diarios y se reconstruye la lógica periodística que lo informa, confrontándola con la lógica jurídica que guía la actuación del tribunal.

La República Democrática del Congo y la misión de paz de las Naciones Unidas

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Wilfredo Robayo

2011-11-01

Full Text Available La República Democrática del Congo ha estado sumida en un conflicto armado durante los últimos años que ha generado consecuencias desastrosas para la población civil y la institucionalidad del Estado congolés. Debido a esta crisis multiforme que ha creado una amenaza contra la paz y la seguridad internacionales, la necesidad de intervención supranacional fue indispensable, lo que dio como resultado la operación de mantenimiento de paz más grande de toda la historia, con aproximadamente veinte mil efectivos en territorio de la RDC, bajo el nombre de la MONUC. Aunque el panorama de la nación debía mejorar con la Misión de Paz, la situación empeoró la crisis humanitaria de los congoleses, dejando consecuencias nefastas e inaceptables como balance de las operaciones auspiciadas por las Naciones Unidas, que debe ser declarada internacionalmente responsable por la violación de los derechos humanos y el derecho internacional humanitario.

Nova República: a violência patronal rural como prática de classe

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Bruno Regina Angela Landim

2003-01-01

Full Text Available Durante a Nova República, disseminou-se junto às associações e sindicatos patronais rurais a certeza de "uma verdadeira guerra no campo" e a "inevitabilidade" da violência como única medida eficaz para conter as ações de ocupação de terras e a demanda por uma reforma agrária. O objetivo deste trabalho é mostrar, tendo como fonte o debate na grande imprensa, que a defesa e a prática da violência pelos grandes proprietários de terra e empresários rurais é estruturante e reflete um habitus que encadeia o passado e o presente numa mesma realidade. A violência revela-nos o conteúdo das relações de classe e expõe os componentes de velhos e novos padrões de conduta. Nos anos 80, ela funcionou como reforço à solidariedade e ao sentimento de pertencimento e serviu também para fortalecer ainda mais a convicção da superioridade dos proprietários sobre os trabalhadores rurais. Não se trata de um ato individual e esporádico; é uma violência ritualizada e institucionalizada, que implica a formação de milícias, a contratação de capangas, a lista dos marcados para morrer e os massacres. E nesse contexto, pouco se distingue o novo empresário do latifundiário tradicional, ou a voz "civilizada das urbes" da "rudeza dos grotões".

The Odda System: Integration of Conventional Programming and Artificial Intelligence Le système ODDA : intégration de programmation classique et d'intelligence artificielle

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Cayeux E.

2006-11-01

Full Text Available The ODDA system (Offshore Directional Drilling Advisor is an example of how numerical packages, a relational database, graphical interfaces and knowledge bases can be integrated into an industrial application. Le système ODDA (Offshore Directional Drilling Advisor est un exemple illustrant la façon dont des progiciels numériques, une base de données relationnelle, des interfaces graphiques et des bases de connaissances peuvent être intégrés dans une application industrielle.

Habilidades sociais de alunos surdos na perspectiva de professores da classe bilíngue, da classe comum e intérprete

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Ana Claudia Paviani Casalli

2017-04-01

Full Text Available Este trabalho objetivou descrever o repertório de habilidades sociais, problemas de comportamento e a competência acadêmica de 15 crianças/adolescentes com surdez, na visão de professores de classe bilíngue, intérprete e de professores de classes comuns. Participaram deste estudo quatro professores e um intérprete, sendo dois de classe comum e dois de classe bilíngue. Utilizou-se como instrumento de coleta de dados, o Sistema de Avaliação de Habilidades Sociais (SSRS-BR. A avaliação dos professores para as três escalas do instrumento – Habilidades Sociais, Problemas de Comportamento e Competência Acadêmica – foi positiva, pois a maioria dos alunos foi classificada com repertórios medianos e altos. Os resultados ainda mostraram-se contrários à hipótese inicial, pois esperava-se que as professoras da classe bilíngue, por atuarem diretamente com os alunos surdos, utilizando a Libras como língua de instrução, pudessem avaliá-los de forma mais positiva, com relação às Habilidades Sociais, Problemas de Comportamento e Competência Acadêmica, quando comparados às avaliações dos professores da classe comum, o que não ocorreu. Conclui-se que de modo geral os alunos surdos foram avaliados com um repertório mediano de habilidades sociais e competência acadêmica, sendo os professores da classe comum os que fizeram avaliações mais positivas. Sugere-se que pesquisas com a utilização de outras medidas de avaliação sejam realizadas para aprofundar e confirmar os dados obtidos.

Atuação do intérprete educacional: reflexão e discussão sobre as duas modalidades de interpretação-simultânea e consecutiva

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Neiva de Aquino Albres

2017-02-01

Full Text Available Procuramos caracterizar os aspectos tipicamente relacionados à interpretação educacional em sala de aula inclusiva que atendam alunos surdos problematizando o uso de interpretação de e para Libras nas modalidades simultânea e consecutiva como técnicas a serem adotadas pelo intérprete educacional. Para além da modalidade interpretação como técnica, há questões fundamentais de construção de sentido que perpassam as atividades em sala de aula. Estabelecendo reflexões sobre a interpretação em espaço educacional como em aula expositiva, em atividades interativas e nos processos de avaliação, entendemos que para a decisão sobre qual modalidade de interpretação é mais adequada a cada momento é preciso equacionar os fatores de competência linguística do intérprete, suas habilidades pessoais, preferências de modalidade, contexto, conhecimento do enunciador e do discurso e tempo.

L’intégration du capital humain dans un outil de pilotage de la performance : le cas du tableau de bord stratégique

OpenAIRE

Borchani, Manel; Cheffi, Walid

2005-01-01

Cette communication examine comment un outil de contrôle de gestion, le tableau de bord stratégique (TdB), permet-il d’intégrer le capital humain dans le pilotage de la performance globale de l’entreprise ? La théorie des ressources (resource based view theory) considère que les Ressources Humaines (RH) sont des ressources internes précieuses pour l’entreprise. Cette théorie établit un lien entre elles, les compétences distinctives et l’avantage concurrentiel durable de l’entreprise. Un tel a...

Morfometría fluvial aplicada a una cuenca urbana en Ingeniero White, República Argentina

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Alicia María Campo

2012-04-01

Full Text Available La morfometría fluvial estudia diversas variables que caracterizan la forma de una cuenca de drenaje. El objetivo de este trabajo es aplicar el método morfométrico de cuencas naturales a una cuenca urbana. El área en estudio (6 km2 drena sus aguas al frente costero y comprende la localidad de Ingeniero White, República Argentina. Se realizó la jerarquización de la red de drenaje. Se identificaron tres subcuencas con escasa pendiente que presentan eventos de inundación, con mayor peligrosidad con precipitaciones extremas. Los valores de relación de longitud indicaron mayor concentración de energía en eventos de grandes avenidas. Los valores de relación de elongación demostraron que una de las subcuencas es de forma circular y presenta mayor velocidad en las avenidas de la escorrentía. Las dos cuencas más elongadas tienen mayor retardo en las avenidas. El mayor caudal del área en estudio fluye por la cuenca que posee el mayor número de orden y la mayor superficie. Las otras dos cuencas están sujetas a crecientes instantáneas y de respuesta inmediata. Los valores de pendiente y de área aplicados a modelos hidrológicos e hidraúlico determinaron la sección de los conductos y canales. El caudal calculado para el área drenada fue de 22.41 m3/s.

El papel del movimiento Quinta República en la recomposición del régimen político venezolano (1998-2000

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Jose Honorio Martinez Torres

2014-02-01

Full Text Available En el presente texto se analiza cómo en medio de la descomposición del régimen político punto fijista un sector de las Fuerzas Armadas encabezó y logró constituirse en la alternativa de recomposición y relegitimación del Estado venezolano. Se describen los orígenes del Movimiento Quinta República (MVR, su orientación ideológica y discursiva, sus formas de organización y acción, las tácticas electorales que utilizó para producir un nuevo orden constitucional, los conflictos que suscitó dicho proceso y las reformas políticas y económicas más significativas que se establecieron con la Constitución Política de 1999. Finalmente se esboza la importancia que tuvieron las reformas producidas en el aparato del Estado, la renovación de los funcionarios de alto nivel, y los resultados mayoritarios obtenidos por el gobierno en los procesos electorales del período 1998-2000 para la constitución de una nueva hegemonía en la conducción del régimen político venezolano. Palabras clave: punto fijismo, Movimiento Quinta República, bolivarianismo, globalización neoliberal. __________________Abstract:In this article the author studies a sector of the Venezuelan Army that became the alternative to recompose and legitimatize the Venezuelan State during the political regime named “punto fijo”. In the same sense, it describes the creation of the Fifth Republic Movement, its ideological orientation, its structure and action process, its electoral tactics which got a new constitutional order, the conflicts coming from the emergence of such political party, and state and economic reforms by the Constitution of 1999. Finally, the author talks about the importance of the reforms, the renewal of nigh level civil servants, and the effective electoral results of the Fifth Republic Movement during the period 1998-2000, that constituted a new Venezuelan hegemonic policy order.Keywords: Punto fijo, Fifth Republic Movement, Bolivarianismo

Jornadas humanitarias de labio y paladar hendidos en el sureste de la República Mexicana: 17 años de experiencia y 40 jornadas

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María S. Flores-Méndez

Full Text Available Iniciamos las jornadas quirúrgicas de labio y paladar hendidos como una necesidad hacia la población más desprotegida del sureste de la República Mexicana, ya que esta malformación se presenta en nuestro país en 1 de cada 700 nacidos vivos, afectando a un sector de la población que generalmente no tiene seguridad médica, y siendo pocos además los cirujanos plásticos en el país que tratamos esta patología. Es decir, existen aproximadamente 10 nuevos casos por día, y según las estadísticas, 4 de ellos no tendrán acceso gratuito a los servicios públicos de salud. La Clínica de Labio y Paladar Hendidos inició su actividad en el año 2000 en la Ciudad de Mérida, Yucatán, en el Hospital "Dr. Agustín O'Horan" de la Secretaría de Salud de Yucatán, bajo el nombre de "Todo por una sonrisa". Trabaja de forma continua todo el año, y operando un promedio de 3 a 4 pacientes de labio y paladar hendido a la semana. Además, en ella se realiza una jornada quirúrgica cada año y en los estados del sureste de la República Mexicana se han realizado otras 22 jornadas quirúrgicas, todas en hospitales donde hay uno o más cirujanos plásticos y/o cirujano maxilofacial, aunque no haya clínica de labio y paladar hendido. Todos los pacientes intervenidos a lo largo de 17 años de experiencia y 40 jornadas realizadas lo han sido por labio y paladar hendidos, con secuelas de esta malformación con o sin otras anomalías faciales agregadas.

Escribirlo al fin: Visto al pasar. República, guerra y exilio de María del Carmen García Antón. Memoria desde el destierro en Argentina

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Adriana Virginia Bonatto

2006-11-01

Full Text Available Visto al pasar. República, guerra y exilio is the autobiographical story of a woman from the Republican faction who was driven to permanent exile in Argentina after the Spanish Civil War. The documentary value of her book resides not only in its detailed reconstruction of life and habits during the years of the war, but also in the experiences of Carmen García Antón with world-wide known writers and artists. Moreover, the book invites a reflection on the strategies to legitimize and construct the subject's identity in contemporary Autobiography.

Aproximación a ciertas nociones de historicidad en la prensa colombiana durante la Independencia e inicios de la República en Colombia (1810-1827

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Rodgrigo de J. García Estrada

2017-01-01

Full Text Available Mediante un estudio sistemático de la prensa publicada en distintas ciudades de la actual Colombia durante la Independencia y los primeros años de la república de Colombia (llamada por los historiadores Gran Colombia, para no confundirla con la actual se analiza el contenido de los conceptos utilizados por los colaboradores y editores de los periódicos tratando de entender la semántica de nociones relacionadas con la historicidad, entre otros: historia, devenir, tiempo, permanencia y cambio; pasado, presente y futuro. Se muestran las evidencias de temporalidad propias del proceso revolucionario a partir de 1810, analizando la aceleración de los acontecimientos y su frecuencia, que dificultaba a los ciudadanos su registro y discernimiento.

La Acadèmia d’Educació Física de Catalunya. Un intento para legitimar un espacio institucional y doctrinal de la educación física en la II República

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Xavier Torrebadella i Flix

2013-12-01

Full Text Available Durante la II República española (1931-1939, en Catalunya se proyectaron algunas de las principales instituciones de la educación física y del deporte que continúan presentes. Esta institucionalización vino espoleada por la Acadèmia d’Educació Física de Catalunya (AEFC a partir de ahora, objeto del presente estudio. Descubrimos, pues, a partir de fuentes documentales primarias y otros estudios paralelos, la relevancia de este organismo y la influencia que ejerció para dotar a los proyectos de educación física y del deporte catalanes de una representación democrática, académica, profesional, científica y nacional. En la forzada coyuntura de la II República, la AEFC significó para el país una contribución profesional y técnica que fue más allá de las rivalidades ideológicas y políticas. A pesar del tiempo transcurrido, opinamos que en la actualidad una Nova Acadèmia d’Educació Física de Catalunya podría representar los intereses académicos y los de una disciplina científica y pedagógica que avanza en continua crisis y transformación.

La Primera línea de la Falange contra la República

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José Antonio Parejo Fernández

2005-01-01

Full Text Available Partido de retaguardia, reunión de emboscados, así fue como al poco tiempo comenzó a ser vista la Falange por sus propios socios. Emboscados, en principio, lo fueron aquellos individuos, malos españoles en el imaginario colectivo de la derecha reaccionaria, que pudieron luchar contra la República y no lo hicieron. En la práctica, sin embargo, dicho calificativo respondió a un sentimiento muy concreto que se extendió por buena parte de la España Nacional y que vino a identificar a aquellos malos patriotas con los falangistas de la retaguardia. Así, mientras aquellos oportunistas conspiraban a salvo de las balas para imponer su modelo de estado totalitario y excluyente, en los frentes de batalla y a decir de los reaccionarios luchaban muchos españoles con nobleza y elevación de espíritu. Las continuas concentraciones, los desfiles, las misas al aire libre, los rituales nocturnos de antorchas protagonizadas por la Falange, aquella acusación, sin duda legítima a tenor de todo esto, se apoyó, no obstante, en una percepción torcida de la realidad.Ambushed, in principle, they were it who they could fight against the Republic and they didn’t make it. In the practice, however, that epithet was used by the reactionary right to attack the falangists of the rearguard. According to the reactionaries, while those opportunists conspired safe of the bullets to impose their model of totalitarian state, in the battle fronts many Spaniards fought with nobility and spirit elevation. The continuous concentrations, the parades, the religious rituals outdoors, the night rituals of brands played by the Falange, that accusation leaned on, nevertheless, in a bent perception of the reality. With this article, therefore, and using unpublished documental sources, we want to analyze the contribution of a Falange that became a fundamental pillar for the overthrow of the Second Spanish Republic in very little time.

Aplicação da técnica de REP - PCR no rastreamento de Staphylococcus aureus em sala de ordenha, para o monitoramento da qualidade do leite

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Lea Chapaval

2006-06-01

Full Text Available A identificação e classificação bacteriana são de suma importância no ambiente, na indústria, na medicina veterinária, na microbiologia e na ecologia microbiana. Um número de diferentes métodos genotípicos e fenotípicos estão sendo empregados para identificação e classificação microbiana. A técnica de REP-PCR é baseada no uso de primers sintetizados a partir de sequências repetidas de DNA, chamadas de palindrômicas extragênicas repetidas (REP, e têm sido descrita como um método o qual gera impressões digitais (fingerprints de DNA que podem diferenciar bactérias entre gêneros e espécies. Neste estudo, o método de fingerprint foi usado para Staphylococcus aureus com o objetivo de avaliar a higiene de ordenha em duas fazendas leiteiras. Foram obtidos vários fingerprints de todos os isolados coletados das diferentes fontes estudadas (mãos de ordenhadores, tetos das vacas, leite e ordenhadeira, e foram obtidos comportamentos muito similares das bandas indicando que os isolados podem ser relatados como clones epidemiológicos. Em nosso estudo, a técnica mostrou ser eficiente para a análise da similaridade entre indivíduos da mesma espécie, no caso, o Staphylococcus aureus, mostrando ser uma ferramenta útil para investigação de falhas no manejo e, em um controle mais eficiente para evitar e/ou diminuir a disseminação de microrganismos causadores de sérias enfermidades em humanos e em animais, que podem ser transmitidas através de produtos como o leite e seus derivados.

Representações interculturais de gênero no romance A república dos sonhos, de Nélida Piñon

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Lúcia Osana Zolin

2012-01-01

Full Text Available Brazilian author Nélida Piñon's novel A república dos sonhos (The Republic of Dreams (1984 engages, on the one hand, gender representations of a medieval- inspired Galicia, with its oral traditions, pilgrimages and emigrants. On the other hand, the gender representations in 20th century Brazil provide a highly interest view of female emancipation brought about by feminist movements. The novel re- veals the process of discordant voices with regard to hegemonic ideologies such as patriarchy and phallogocentrism commonly represented and replicated in canoni- cal literature. Instead of the traditional feminine identity characterized and fixed by patriarchy-established gender female roles, she inscribes multiplicity and het- erogeneity. In other words, the decentralization of identities intersects with other issues such as race, ethnicity, class and sexual orientation as constitutive of the contemporary Brazilian society. Foregrounded on concepts from critical feminism and post-structuralism, a discussion ensues on the way a contemporary Brazilian female writer, dialoging with Spanish tradition, represents feminine identities and gender relationships in this important 20th century novel.

tavg1_2d_int_Nx: MERRA 2D IAU Diagnostic, Vertical Integrals and Budget Terms, Time Average 1-hourly 0.667 x 0.5 degree V5.2.0 (MAT1NXINT) at GES DISC

Data.gov (United States)

National Aeronautics and Space Administration — The MAT1NXINT or tavg1_2d_int_Nx data product is the MERRA Data Assimilation System 2-Dimensional vertical integral that is time averaged single-level at the native...

Orientations pour l'intégration des TICE dans l'enseignement du français en Syrie. L'exemple du centre de documentation pédagogique de Damas.

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Christelle Demange-Ducrot

2005-09-01

Full Text Available Le secteur éducatif syrien souhaite orienter son action vers les nouvelles technologies de l'information et la sensibilisation du public scolaire aux applications de l'informatique dans le domaine éducatif et en particulier dans le cadre de l'enseignement des langues. Dans l'enseignement-apprentissage des langues, les apports des TICE sont nombreux, mais là où elles apportent sans doute la plus grande plus-value, c'est lors de la mise en place de projets de classe motivants et valorisants, intégrés à des projets de communication authentique. Partant de ce constat, le Centre de Documentation Pédagogique de Damas forme les enseignants de français syriens à l'intégration des TICE dans des projets pédagogiques de classe mettant en œuvre des activités créatives et stimulantes pour communiquer en français. Jusqu'alors, les formations ont centré leurs efforts sur les bases de l'environnement informatique et de la bureautique, avec pour parti pris l'utilisation de logiciels libres. L'année 2005 marquera le lancement et l'expérimentation du dispositif de formation continue à distance destiné aux professeurs de français dans le domaine des TICE.

Adaptación y validación del cuestionario CUVE³-EP para la evaluación de la violencia escolar en centros de enseñanza básica de la República Dominicana

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David Álvarez-García

2015-10-01

Full Text Available El objetivo de este trabajo fue diseñar y validar una versión del cuestionario CUVE³-EP (Álvarez-García, Núñez y Dobarro, 2012 adaptada al contexto de las escuelas de Enseñanza Básica de la República Dominicana. El cuestionario fue puesto a prueba con 1945 estudiantes de 5º, 6º, 7º y 8º grado del Nivel Básico, con edades comprendidas entre los 11 y los 17 años, pertenecientes a 14 centros educativos de Santo Domingo. Los análisis factoriales confirmatorios realizados muestran que el modelo que mejor ajusta a los datos es el compuesto por siete tipos de violencia escolar: violencia verbal entre estudiantes; violencia verbal de alumnado hacia profesorado; violencia física directa y amenazas entre estudiantes; violencia física indirecta por parte del alumnado; exclusión social entre estudiantes; disrupción en el aula; y violencia de profesorado hacia alumnado. Tras examinar sus propiedades psicométricas, se concluye que la adaptación del cuestionario CUVE³-EP presentada en este trabajo constituye un instrumento fiable y válido para la evaluación de la violencia escolar en los centros de Enseñanza Básica de la República Dominicana.

Identification of CTX-M15-, SHV-28-producing Klebsiella pneumoniae ST15 as an epidemic clone in the Copenhagen area using a semi-automated Rep-PCR typing assay

DEFF Research Database (Denmark)

Nielsen, J B; Skov, M N; Jørgensen, R L

2011-01-01

pneumoniae (K. pneumoniae) producing extended spectrum β-lactamases (ESBLs) and their relation to recognized Danish outbreak strains. PFGE and Rep-PCR produced similar clustering among isolates. Individual isolates from each cluster were further characterized by PCR amplification and sequencing of bla (TEM......), bla (SHV), and bla (CTX-M), and multilocus sequence typing (MLST). Thirty-five out of 52 ESBL-producing K. pneumoniae isolates were ST15 and bla (CTX-M15), bla (SHV-28), and bla (TEM-1) positive by PCR. Ten out of 52 were ST16 and tested positive for bla (CTX-M15), bla (SHV-1), and bla (TEM-1...

O papel criador do intérprete na efetividade do princípio da dignidade humana

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Bernardo

2014-07-01

Full Text Available Dignidade da pessoa humana, como conceituá-la? Cecília Meirelles definiu, de maneira poética, o vocábulo liberdade: “Essa palavra que o sonho humano alimenta. Que não há ninguém que explique e ninguém que não entenda”. Destarte, pode-se, por analogia, transportar os belos versos para o Direito, e, dessa forma, referir-se à dignidade humana. Realmente, não é tarefa simples definir dignidade, pois seus contornos são, propositadamente, imprecisos e vagos. Nesse sentido, este artigo expõe um estudo da dignidade humana como princípio e em seus aspectos filosóficos e jurídicos, levando ainda em conta a participação do Legislativo, do Judiciário e da própria sociedade para a sua concretização e efetivação, a fim de se chegar a uma análise ao menos razoável desse valor, e, assim, compreender a função do intérprete diante da perspectiva de sua atividade criativa e criadora.

Tradução Oral à Prima Vista na formação do intérprete: considerações pedagógicas

OpenAIRE

Gloria Regina Loreto Sampaio

2017-01-01

A Tradução Oral à Prima Vista (TrPV) é um elemento de relevância para a formação do intérprete e um componente essencial para o desempenho do futuro profissional em muitos ambientes de atuação. Consequentemente, a prática da TrPV se faz presente em cursos de formação bem estruturados. Neste escrito, após uma breve referência à natureza, complexidade e desafios impostos pela TrPV, e tendo como base uma vivência docente extensa da autora, será apresentada uma possível abordagem pedagógica, volt...

Propuesta de metodología para la implantación de un sistema de gestión ambiental basado en la norma ISO 14001 en la industria cementera en República Dominicana

OpenAIRE

García de la Cruz, Isaura

2017-01-01

El presente trabajo fin de master (TFM) se centra en la propuesta de la metodología para la implantación de un sistema de gestión ambiental en la industria cementera en República Dominicana basado en la Norma Internacional ISO 14001:2015. Uno de los objetivo principales de esta investigación es el proponer dicha metodología para que sirva de soporte común en la industria cementera, en cualquier de los diversos tipos de organización (de tamaño promedio o multinacionales) para facilitar la imp...

El protestantismo en la España de la II República a la luz de los informes del Archivo Secreto Vaticano

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Hernández Figueiredo, José Ramón

2011-06-01

Full Text Available On the eve of the Second Republic, an important worry of the Catholic Church is the condition and development of the Protestantism in Spain. Such worry comes directly from the Pope Pio XI that through the Minister asks the Nuncio Tedeschini an exact and complete report about the different Christian confessions in the Iberican Peninsula. About it, there are abundant unpublished information that comes from all the Spanish dioceses.

En vísperas de la Segunda República, una preocupación importante de la Iglesia es el estado y desarrollo del protestantismo en España. Tal preocupación procede directamente del Papa Pío XI que por medio del Secretario de Estado pide al Nuncio Tedeschini un informe exacto y completo de las diversas confesiones cristianas en la Península. Al respecto, son abundantes los datos inéditos que proceden de todas las diócesis españolas.

Archaïsme et construction identitaire en Grande-Grèce : notes sur le Palladion d’Athénadans la céramique italiote Archaism and Construction of Identity in Magna Graecia : Notes on the Palladion of Athena in the Italiot Ceramics Arcaismo e costruzione di identità nella Magna Grecia: note sul Palladion di Atena nella ceramica italiota

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Claude Pouzadoux

2011-07-01

Full Text Available Cet article se penche sur la nature et la signification des éléments d’archaïsme que l’on peut repérer dans la céramique italiote de la deuxième moitié du IVe siècle avant J.-C. Il s'intéresse notamment à la représentation du Palladion d'Athéna.This article focuses on the nature and meaning of the archaic elements that can be identified in the Italiot ceramics of the second half of the fourth century BC. Its interests include the representation of the Palladion of Athena.Questo articolo si sofferma sulla natura e il significato degli elementi arcaici che si rinvengono nella ceramica italiota della seconda metà del IV sec. a.C. Affrontra in particolare la rappresentazione del Palladion di Atena

Interactions, strings and isotopies in higher order anisotropic superspaces

CERN Document Server

Vacaru, Sergiu Ion

2001-01-01

The monograph summarizes the author's results on the geometry of anholonomic and locally anisotropic interactions, published in J. Math. Phys., Nucl. Phys. B, Ann. Phys. (NY), JHEP, Rep. Math. Phys., Int. J. Theor. Phys. and in some former Soviet Union and Romanian scientific journals. The main subjects are in the theory of field interactions, strings and diffusion processes on spaces, superspaces and isospaces with higher order anisotropy and inhomogeneity. The approach proceeds by developing the concept of higher order anisotropic (super)space which unifies the logical and manthematical aspects of modern Kaluza--Klein theories and generalized Lagrange and Finsler geometry and leads to modeling of physical processes on higher order fiber (super)bundles provided with nonlinear and distinguished connections and metric structures. This book can be also considered as a pedagogical survey on the mentioned subjects.

La nouvelle-tableau (2

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Géraldine Jenvrin

2012-06-01

Full Text Available La nouvelle « Frémissante, la feuille se flétrit » met en scène le trouble d'un détenu qui par les seuls objets dont il dispose, lutte pour s'échapper intérieurement. L'usage du regard cinématographique porté sur les détails infimes de la matérialité carcérale, leur exposition sous forme de tableaux se faisant échos, les techniques de l’anonymat et du brouillage des repères objectifs, portent à son comble les dimensions énigmatiques et l'esthétique de la  brièveté propre à la nouvelle tout en permettant de  représenter la résistance de l'homme à l'enfermement et à la persécution.

Sobre os meios e modos de fazer jornalismo na Primeira República: Lima Barreto entre a história e a ficção

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Denilson Botelho

2013-06-01

Full Text Available Este artigo consiste na análise de um conto de Lima Barreto (1881-1922, intitulado “O jornalista”, publicado na revista Souza Cruz, em 1921, a partir do qual se discute e examina os meios e modos de fazer jornalismo na Primeira República. Tomando a literatura como fonte e como um tipo de documento, investiga-se o significado dessa publicação, bem como sua relação com outros textos do autor, a fim de perceber o quanto são capazes de revelar sobre as lutas travadas no universo da imprensa. Trata-se de resultados parciais de pesquisa desenvolvida no campo da história social da cultura, tendo como referenciais teóricos as contribuições de E. P. Thompson e Raymond Williams.

Aspectos da representação de Marco Túlio Cícero nos compêndios de História Universal do Ensino Secundário na Primeira República Brasileira (1889-1930 * Aspects of the representation of Marcus Tullius Cicero in textbooks on Universal History of the Second

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ANDRÉ LUIZ CRUZ TAVARES

2012-04-01

Full Text Available O artigo tem como objetivo o estudo das origens e das características da representação de Marco Túlio Cícero (106-43 a.C. nos compêndios de História Universal utilizados no Ensino Secundário durante a Primeira República do Brasil (1888-1930, bem como a utilização dessa representação na construção identitária nacional republicana brasileira no início do século XX. Palavras-chave: Cícero – República – Brasil. Abstract: This paper aims to study the origins and characteristics of the representation of Marcus Tullius Cicero (103-46 BC in textbooks on Universal History used in Secondary Education during the First Republic of Brazil (1889-1930, as well as use of this representation in the Brazilian republican national identity construction in early twentieth century. Keywords: Cicero – Republic – Brazil.

Del margen al centro: lo femenino y la filosofía en el Gorgias y en República V de Platón

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Laura Victoria Almandós Mora

2009-10-01

Full Text Available En la Atenas de Platón, las mujeres no formaban parte del gobierno. La sorprendente propuesta del libro V de la República en la que las mejores mujeres debían gobernar con los mejores varones es consecuencia del principio, defendido por el autor, de que la vida política debía llevarse a cabo en virtud de la capacidad racional y el carácter de los gobernantes. La vulnerabilidad de Sócrates demostraba los límites de la política real que, a su vez, se basaba en el principio de dominio y el ideal masculino de entonces. Fue posible pensar en un gobierno de marginados, en el que tendrían asiento las mujeres amantes de la sabiduría y sus compañeros filósofos, porque se estaba erosionando el modelo masculino tradicional.

GeoInt: the first macroseismic intensity database for the Republic of Georgia

Science.gov (United States)

Varazanashvili, O.; Tsereteli, N.; Bonali, F. L.; Arabidze, V.; Russo, E.; Pasquaré Mariotto, F.; Gogoladze, Z.; Tibaldi, A.; Kvavadze, N.; Oppizzi, P.

2018-05-01

Our work is intended to present the new macroseismic intensity database for the Republic of Georgia—hereby named GeoInt—which includes earthquakes from the historical (from 1250 B.C. onwards) to the instrumental era. Such database is composed of 111 selected earthquakes and related 3944 intensity data points (IDPs) for 1509 different localities, reported in the Medvedev-Sponheuer-Karnik scale (MSK). Regarding the earthquakes, the M S is in the 3.3-7 range and the depth is in the 2-36 km range. The entire set of IDPs is characterized by intensities ranging from 2-3 to 9-10 and covers an area spanning from 39.508° N to 45.043° N in a N-S direction and from 37.324° E to 48.500° E in an E-W direction, with some of the IDPs located outside the Georgian border, in the (i) Republic of Armenia, (ii) Russian Federation, (iii) Republic of Turkey, and (iv) Republic of Azerbaijan. We have revised each single IDP and have reevaluated and homogenized intensity values to the MSK scale. In particular, regarding the whole set of 3944 IDPs, 348 belong to the Historical era (pre-1900) and 3596 belong to the instrumental era (post-1900). With particular regard to the 3596 IDPs, 105 are brand new (3%), whereas the intensity values for 804 IDPs have been reevaluated (22%); for 2687 IDPs (75%), intensities have been confirmed from previous interpretations. We introduce this database as a key input for further improvements in seismic hazard modeling and seismic risk calculation for this region, based on macroseismic intensity; we report all the 111 earthquakes with available macroseismic information. The GeoInt database is also accessible online at http://www.enguriproject.unimib.it and will be kept updated in the future.

Sur la reconnaissance de la compétence exclusive des groupements religieux afin d‘instaurer leur structure intrinsèque et les normes intérieures des relations en tant qu’une des garanties ...

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Philip Ryabykh

2012-11-01

SOMMAIRE: 1. Brève histoire de l’affaire – 2. Préambule – 3. Protection de la compétence exclusive des groupements religieux en vue d’instaurer leur structure intrinsèque et les normes intérieures des relations au point de vue de la législation de la Roumanie – 4. Application du principe de l’autonomie des groupements religieux et du principe de l’inadmissibilité d’intervenir pour l’État aux affaires intérieures des groupements religieux – 5. Non-contradiction de la Convention des exigences intérieures des groupements religieux sur la loyauté et la conformité des personnes se trouvant dans les relations de service avec le groupement religieux – 6. Absence des raisons fournies par les faits juridiques suffisantes et justifiant réellement l’assimilation (la mise au même niveau des groupements religieux avec n’importe quelles autres organisations-employeurs dans la sphère de la réglementation des relations de travail – 7. Légalité de l’instauration des restrictions à la création et les activités des syndicats dans les certaines sphères des relations publiques – 8. Compétence de la Roumanie de fixer dans la législation les restrictions à la liberté des syndicats conformément à la sphère des relations religieuses – 9. Signification des résultats du jugement de l’affaire «Syndicat “Le Bon Pasteur” c. Roumanie» (requête 2330/09 pour L’Église Orthodoxe Russe- 10. Conclusion.

"Cy Twombly: Intérprete de dos mundos" [Un artista entre Estados Unidos y Europa, entre lo clásico y lo contemporáneo

OpenAIRE

Gras Cruz, Irene

2017-01-01

Esta tesis “Cy Twombly: Intérprete de dos mundos” [Un artista entre Estados Unidos y Europa, entre lo clásico y lo contemporáneo] pretende dar a conocer al artista norteamericano Cy Twombly (1928-2011) en nuestro país y destacar la importancia que tiene dentro del panorama artístico como figura clave en un momento de efervescencia —artística y creativa— americana en el que a diferencia de sus coetáneos prefirió emigrar a Europa, concretamente a Italia. Mientras todos se trasladaban a la nueva...

Gender identities and left-wing political culture in twentieth-century Spain | Identidades de género y culturas políticas en la Segunda República

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Ana Aguado

2008-12-01

Full Text Available This article explores the relationship between political culture, female citizenship and gender identities, and more specifically, the shaping of particular gender identities linked to republican political culture and made possible by the political and legislative framework of the Second Republic. With the attainment of female citizenship in the Constitution of 1931, the new context made it possible for a new gender identity to develop. The political activism of women in Valencia during the Second Republic shows how women’s organizations which emerged from within republican political parties encouraged the participation of women in the public sphere. Republican women linked to the Autonomist Republican Union Party (Partido de Unión Republicana Autonomista or P.U.R.A. began to set up Republican Women’s Groups, many of whose members would subsequently constitute the Antifascist Women’s Group. | Este artículo plantea un análisis de la relación entre culturas políticas, ciudadanía femenina e identidades de género. Concretamente, la formación de unas específicas identidades de género vinculadas a las culturas políticas republicanas, posibilitadas por el marco político y legislativo de la Segunda República. Junto con la consecución de la ciudadanía femenina con la Constitución de 1931, el nuevo contexto significó la condición de posibilidad para el desarrollo de una específica identidad de género. El activismo político de las mujeres en la Valencia de la Segunda República muestra cómo las organizaciones femeninas surgidas dentro de los partidos políticos republicanos fomentaron la participación de las mujeres en el espacio público. Las mujeres republicanas vinculadas al Partido de Unión Republicana Autonomista P.U.R.A. comenzaron a articular Agrupaciones Femeninas Republicanas, cuyas bases nutrirían en buena parte, posteriormente, la implantación de la Agrupación de Mujeres Antifascistas.

Lepra y sociedad en la España de la primera mitad del siglo XX: la Colonia Sanatorio de Fontilles (1908-1932) y su proceso de intervención por la Segunda República

OpenAIRE

Bernabeu Mestre, Josep; Ballester Artigues, Teresa

1991-01-01

La investigación analiza el proceso de intervención de la Leprosería de Fontilles llevado a cabo por la Segunda República en 1932. En una primera parte se exponen las bases institucionales y asistenciales que, caracterizaban a la Colonia Sanatorio de Fontilles en su primera etapa (1908-1932), para estudiar a continuación las razones que condujeron a las autoridades sanitarias del Nuevo Estado a decidir la incautación, y las consecuencias y reacciones científicas, sociales y políticas que aque...

L'intégration de l'olympisme à l'école : contribution du Programme d'Education aux Valeurs Olympiques – PEVO à la construction d'un monde moderne

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Bipona Emmanuel Bienvenu

2016-01-01

Il est question d'intégrer la formation et l'éducation des jeunes à travers la pratique sportive dans la construction des générations olympiques. Dans le cadre de la transmission inter générationnelle des valeurs positives Toutes les stratégies organisationnelles et de diffusion doivent être conçues pour captiver l'attention des jeunes à travers des symboles visibles et des supports édifiants pour leur vie quotidienne.

Universidad Abierta para Adultos: un modelo de educación a distancia en la República Dominicana

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Fernando Hernández

2006-06-01

Full Text Available La Universidad Abierta para Adultos, UAPA ubicada en Santiago de los Caballeros en República Dominicana, inicia sus labores docentes y administrativas en el año 1995. En 12 años de existencia ha graduado 5.094 profesionales en las áreas de Psicología, Idiomas, Negocios, Ciencia Jurídicas y Educación. Esta institución se encuentra organizada bajo una estructura departamental que incluye Escuelas, Departamentos, Institutos y Centros. El gobierno se articula a través de órganos colegiados (Junta de Directores, Consejo Académico y Comisión Consultiva y órganos unipersonales (Rector, Vicerrectores, Directores de Escuelas, Departamentos, Institutos y Centros. La acción docente que se desarrolla en la UAPA se fundamenta en el principio de responsabilidad compartida entre los participantes y el facilitador. La metodología empleada es activa y participativa y las técnicas de aprendizaje se basan en la actividad de los que aprenden. Desde sus inicios ha tratado de favorecer el aprendizaje de sus participantes haciendo uso de metodologías didácticas con aplicaciones de las TICs. En la actualidad la Universidad dispone de su propio portal educativo que funciona en una plataforma Web propia que le sirve de apoyo a los programas no presenciales o virtuales y a la implementación de cursos en líneas de educación permanente.

La science comme pratique d’intégration dans la société des princes. Les Grimaldi de Monaco et la curiosité savante (xviie–

OpenAIRE

Fouilleron, Thomas

2015-01-01

Jusque-là seigneur de Monaco, Honoré II (1597-1662) prend, en 1612, le titre de prince. En 1641, il se place sous la protection du roi de France qui confirme, par le traité de Péronne, sa souveraineté. Parallèlement à son effort d’affirmation politique, il s’attache à intégrer la société européenne des princes en adoptant les pratiques culturelles de la distinction monarchique.Souverains à Monaco et grands aristocrates en France, les Grimaldi constituent, au xviie siècle, des cabinets de curi...

Entre o fechamento e a abertura: a trajetória do PC do B da guerrilha do Araguaia à Nova República (1974-1985 Between the closing and the opening: the path of the "PC do B" from the Araguaia guerrilla to the New Republic (1974-1985

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Jean Rodrigues Sales

2007-01-01

Full Text Available O objetivo deste artigo é discutir a história do Partido Comunista do Brasil (PC do B no período compreendido entre o final da guerrilha do Araguaia, em 1974, até a Nova República Brasileira, com a chegada de José Sarney à presidência da República, em 1985. A análise está voltada para o entendimento do processo de mudança na linha político-partidária, que procura adaptar-se ao processo de democratização pelo qual passava o Brasil.The objective of the present article is to discuss the history of the Brazilian Communist Party (PC do B during the period that stretches from the Araguaia guerrilla in 1974 to the consolidation of the New Brazilian Republic with José Sarney elected President of the Republic in 1985. Our analysis focuses on understanding the process of change of the political line of the party as the latter seeks to adapt to the process of democratization Brazil underwent at that time.

Upgrading from the Dicon Wiring Management system to IntEC at the Gentilly 2 station

International Nuclear Information System (INIS)

Theoret, P.A.

1995-01-01

The General Electric DICON Wiring Management system supplied to HQ during the construction of G2 is currently being replaced by the stand-alone version of the IntEC software developed by AECL. The reasons for replacing DICON and choosing lntEC are discussed. The different aspects of the two year DICON data conversion project are presented with the problems encountered and the means that were taken to resolve the problems. lntEC has shown our DICON data to be considerably more deficient than we had thought. This has increased the cost and the duration of the conversion process. However, correcting the errors during the conversion process provides us with much more accurate data. This should be viewed as an investment in configuration management. Many potential causes of future errors and potentially critical path delays have been removed. We have chosen to document the detailed procedures for the use of lntEC in our plant using a Windows Help File compiler. This also has been found to be extremely useful as a training tool as well as providing on-line help. The DICON data conversion into lntEC will not be completed until 1996. lntEC is not perfect. However, from what we have up to now, we are satisfied with the conviviality and efficiency of lntEC and with AECL's diligence in constantly aspiring in making it a better product. (author)

Archivage électronique : spécifications relatives à la conception et à l'exploitation de systèmes informatiques en vue d'assurer la conservation et l'intégrité des documents stockés dans ces systèmes

CERN Document Server

Association Française de Normalisation. Paris

2007-01-01

Archivage électronique : spécifications relatives à la conception et à l'exploitation de systèmes informatiques en vue d'assurer la conservation et l'intégrité des documents stockés dans ces systèmes

L’utilisation de l’hydrolyse enzymatique pour la production de nanocellulose dans une stratégie de bioraffinage forestier intégré (Synthèse Bibliographique)

OpenAIRE

Bombeck, Pierre-Louis; Hebert, Jacques; Richel, Aurore

2016-01-01

Introduction. Dans un monde qui cherche à se défaire de sa dépendance à la pétrochimie, le concept de bioraffinage de la biomasse forestière est de plus en plus étudié. Dans une recherche de valorisation maximale des composants de cette biomasse, la transformation de fibres de cellulose en nanocellulose séduit de plus en plus l’industrie papetière par sa haute valeur ajoutée. Littérature. Le concept de bioraffinage forestier intégré vise l’adaptation des usines de pâte à papier en bioraffi...

A natureza dos números na República de Platão

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Anastácio Borges de Araújo Jr.

2010-12-01

Full Text Available É incontestável a presença das matemáticas nos diálogos de Platão, todavia o alcance e o sentido desta presença é matéria de controvérsia entre os especialistas. Alguns acreditam que os temas matemáticos empregados nos diálogos são fantasias matemáticas, outros defendem baseados, sobretudo no testemunho de Aristóteles, que Platão teria substituído na sua hipótese as formas inteligíveis pelos números ideais. Sem tomar partido de antemão nestas querelas, o que propomos aqui é uma investigação acerca da natureza dos números fundamentada exclusivamente nos textos de Platão, particularmente orientada por uma passagem do livro VII do diálogo República(525 b11- c3, em que Sócrates diz o seguinte: "Seria, portanto, conveniente colocar este estudo, ò Glaucon, dentro de uma legislação e persuadir aqueles que vão participar das grandes coisas na cidade a irem ao cálculo e a aplicarem-se a ele, não nos seus afazeres privados, mas até chegarem à contemplação da natureza dos números através da própria intelecção (...".The presence of the mathematics in Plato's dialogues is unquestionable. However, its reach and sense is controversial for some specialists. Some believe that the mathematical themes employed in the dialogues are mathematical fantasies; on the other hand, others defend, based on the Aristotle's testimonies, that Plato would have substituted the intelligible forms by the ideal numbers in his hypothesis. Having not taken part in the quarrel, we propose an investigation on the nature of the numbers based exclusively in Plato's texts, particularly oriented by the a passage in book VII of Republic (525 b11 - c3, in which Socrates says: "Then it would be fitting, Glaucon, to set this study down in law and persuade those who are going to participate in the greatest things in the city to go to calculation and to take it up, not after the fashion of private men, but stay with it until they come to the

A dual agonist of farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice.

Science.gov (United States)

Wang, Xiaoxin X; Luo, Yuhuan; Wang, Dong; Adorini, Luciano; Pruzanski, Mark; Dobrinskikh, Evgenia; Levi, Moshe

2017-07-21

Even in healthy individuals, renal function gradually declines during aging. However, an observed variation in the rate of this decline has raised the possibility of slowing or delaying age-related kidney disease. One of the most successful interventional measures that slows down and delays age-related kidney disease is caloric restriction. We undertook the present studies to search for potential factors that are regulated by caloric restriction and act as caloric restriction mimetics. Based on our prior studies with the bile acid-activated nuclear hormone receptor farnesoid X receptor (FXR) and G protein-coupled membrane receptor TGR5 that demonstrated beneficial effects of FXR and TGR5 activation in the kidney, we reasoned that FXR and TGR5 could be excellent candidates. We therefore determined the effects of aging and caloric restriction on the expression of FXR and TGR5 in the kidney. We found that FXR and TGR5 expression levels are decreased in the aging kidney and that caloric restriction prevents these age-related decreases. Interestingly, in long-lived Ames dwarf mice, renal FXR and TGR5 expression levels were also increased. A 2-month treatment of 22-month-old C57BL/6J mice with the FXR-TGR5 dual agonist INT-767 induced caloric restriction-like effects and reversed age-related increases in proteinuria, podocyte injury, fibronectin accumulation, TGF-β expression, and, most notably, age-related impairments in mitochondrial biogenesis and mitochondrial function. Furthermore, in podocytes cultured in serum obtained from old mice, INT-767 prevented the increases in the proinflammatory markers TNF-α, toll-like receptor 2 (TLR2), and TLR4. In summary, our results indicate that FXR and TGR5 may play an important role in modulation of age-related kidney disease. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

B-learning para inducción del profesorado principiante. El caso del programa INDUCTIO en la República Dominicana

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Carlos Marcelo

2016-01-01

Full Text Available En este artículo describimos el caso de un programa de inducción dirigido al profesorado principiante en el que se utilizan de manera intensiva los recursos digitales (b-learning con diferentes objetivos: creación de comunidades de aprendizaje, reflexión, análisis de la práctica, comunicación, y como consecuencia de ello, contribución al desarrollo profesional. El programa que describimos lo denominamos INDUCTIO (Programa de formación para la inducción del profesorado principiante de la República Dominicana. El programa de formación INDUCTIO se fundamenta en una visión constructivista y conectivista de la formación docente. Además asume los principios de la autoformación y el desarrollo profesional docente basado en la evidencia. Coherente con esta visión, el programa plantea un amplio conjunto de experiencias de aprendizaje que facilita en los docentes principiantes una inserción de calidad en la docencia. En el programa están participando activamente 363 profesores principiantes y 45 mentores. El programa ofrece herramientas tecnológicas para el apoyo al proceso de inducción como son el diario reflexivo, los planes de mejora, los foros, la plataforma de contenidos online, el portal de recursos educativos, los círculos de aprendizaje, etc.

Fracture numérique, fracture sociale : aux frontières de l'intégration et de l'exclusion

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Luc Vodoz

2010-12-01

Full Text Available La fracture numérique est une ligne de rupture symbolique, le tracé d'un clivage entre d'une part les individus ou groupes sociaux qui sont – ou se sentent – bien intégrés à la « société de l'information », d'autre part ceux qui sont – ou se sentent – exclus de cette société. Comme bien d'autres frontières, cette ligne est difficilement visible voire totalement imperceptible dans le terrain. Ce texte relate un cheminement sur la frontière, sur les logiques prévalant à l'articulation entre deux espaces, entre deux réalités comme entre deux points de vue. Il s’efforce de comprendre ce que vivent celles et ceux qui se situent sur la limite, qui tentent de la franchir ou au contraire d'éviter leur expulsion. L’investigation s’est déroulée dans les milieux de la formation professionnelle et continue en matière de TIC. Plus largement, il s'agissait d'examiner les éventuelles correspondances entre intégration à (ou exclusion de la « société de l'information » d'une part, et d'autre part l'intégration (ou l'exclusion sociale plus générale des personnes considérées.Digital gap, social gap: sitting on the boundaries of integration and exclusionThe digital gap is a symbolic demarcation of rupture, a line that traces the separation between individuals or social groups who are – or feel they are –integrated into the “information society”, and those who are – or feel – excluded from this society. As with many other boundaries, this particular line is difficult to perceive or even is totally imperceptible in the field. Analysing a journey on the boundary itself, this text concentrates on the logics emerging from the connection between the two spaces, two realities, two points of view. It attempts to understand what those who find themselves on this limit actually live, as do also those who attempt de jump the gap or on the contrary try to avoid their expulsion. The enquiry took place in a

Vigilancia tecnológica e inteligencia estratégica: creación e implementación del primer programa gubernamental en la temática en la República Argentina en los últimos 4 años

OpenAIRE

Pérez, Nancy Verónica

2016-01-01

Este artículo analiza la puesta en marcha de políticas de gestión de Vigilancia e Inteligencia, a partir de la creación del primer Ministerio de Ciencia, Tecnología e Innovación Productiva de la República Argentina (MINCYT). En principio, se describe el diseño e implementación, en los últimos 4 años, del Primer Programa Gubernamental de Vigilancia Tecnológica e Inteligencia en Argentina, llamado Programa Nacional de Vigilancia Tecnológica e Inteligencia Competitiva (VINTEC) del Mini...

A ciência na mídia e as estratégias de reafirmação da bipolaridade entre os gêneros: o caso do Globo Repórter Science in the media and strategies to reaffirm gender bipolarity between genders: Globo Reporter case study

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Cláudia Regina Ribeiro

2009-06-01

Full Text Available A partir do estudo do programa Globo Repórter, este artigo discute as articulações percebidas na mídia entre natureza e as questões de gênero. Selecionamos dois programas exibidos em semanas consecutivas que empreendem um grande esforço para explicar as diferenças de gênero e o amor materno a partir de noções essencialistas e do privilégio do corpo biológico, indo ao encontro do que as ciências médicas vêm se empenhando em defender na busca de descobertas de "verdades" sobre o tema, e em detrimento dos aspectos sócio-culturais dessas construções.From the study of Globo Repórter television program this article discusses the media articulations between nature and gender issues. We selected two editions, shown in consecutive weeks, which undertake great effort to explain the differences of gender and for maternal love, since essentialists notions and the privilege of the biologic body, in accordance with the efforts these medical sciences have been making in search of the "truth" about the issue, despite the social and cultural aspects of this construction.

Liberalismo a prueba. La expulsión de «extranjeros perniciosos» en México durante la República Restaurada (1867-1876

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Chenillo Alazraki, Paola

2012-08-01

Full Text Available In Mexico, during the Restored Republic (1867-1876, even though Liberalism became a fundamental element of national politics, the defense of legal equality would remain subjected to the strengthening of the State, and the party in power. This article analyzes the expulsion of 17 foreign Jesuits decreed in 1873 by President Sebastián Lerdo de Tejada. A close monitoring of the aftermath and the debate it generated provides evidence of the role this faculty had as a political tool in said process.

En México, durante la República Restaurada (1867-1876, a pesar de que el liberalismo se afianzó como un elemento fundamental en la vida política nacional, la defensa de la igualdad jurídica quedó supeditada al fortalecimiento del Estado y del partido en el poder. En este artículo, se analiza la expulsión de 17 jesuitas de origen extranjero, decretada en 1873 por el presidente Sebastián Lerdo de Tejada. El seguimiento detallado de los acontecimientos y del debate que generó pone en evidencia el papel de esta facultad como una herramienta política en dicho proceso.

Mirando al sur sin perder de vista el norte. México frente a la Unión de Repúblicas Centroamericanas, 1885

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Luz Carregha Lamadrid

2018-04-01

Full Text Available En el artículo se aborda el conflicto surgido en 1885, cuando el general Justo Rufino Barrios, presidente de Guatemala, proclamó de manera unilateral la Unión de Repúblicas Centroamericanas, y aseguró que la establecería aun por la vía armada. También se examina la postura del gobierno mexicano ante el conflicto que estalló y obligó a mirar a la frontera sur, a partir de las notas de los periódicos principales que circulaban entonces en la Ciudad de México, lo que permite también conocer la respuesta de la opinión pública de la época. El objetivo es explorar la política exterior del gobierno mexicano frente a un evento, que adquirió mayor relevancia cuando se extendió el temor de una posible intervención de Estados Unidos en el territorio nacional. Los hallazgos muestran que la reacción del general Porfirio Díaz ante el conflicto centroamericano contribuyó al fortalecimiento de su figura como “héroe de la paz”, que lo caracterizó.

Modélisation de l'intégration de ressources TAL pour l'apprentissage des langues : la plateforme MIRTO

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Claude Ponton

2005-11-01

Full Text Available Le présent article se focalise sur le développement d'outils de traitement automatique des langues (TAL pour l'apprentissage des langues assisté par ordinateur (ALAO. Après avoir identifié les limitations inhérentes aux outils d'ALAO dépourvus de composantes TAL, nous décrivons le cadre général du projet MIRTO, une plateforme de création d'activités pédagogiques fondé sur des outils TAL en développement au sein de notre laboratoire. Cette plateforme est organisée en quatre couches distinctes et successives : fonctions, scripts, activités et scénarios. À travers plusieurs exemples, nous expliquons en quoi l'architecture de MIRTO permet l'implantation de fonctions TAL classiques au sein de scripts, lesquels facilitent la conception, sans compétence informatique préalable, d'activités didactiques, elles-mêmes éventuellement intégrées au sein de séquences plus complexes, ou scénarios.

Report on INT Program INT-17-1a

Energy Technology Data Exchange (ETDEWEB)

Escher, J. E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Blackmon, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Elster, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Launey, K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lee, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Scielzo, N. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2017-04-19

The purpose of the 5-week program was to bring together physicists from the low-energy nuclear structure and reaction communities to identify avenues for achieving reliable and predictive descriptions of reactions involving nuclei across the isotopic chart. The 4-day embedded workshop focused on connecting theory developments to experimental advances and data needs for astrophysics and other applications.

Sotanas, candidatos y petrodólares: la caída de la república conservadora vista por un diplomático francés

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Renán Vega Cantor

1998-05-01

Full Text Available En la historia contemporánea de Colombia, la república conservadora (1885-1930, vista en una perspectiva de larga duración, es fundamental para explicar el retardo en la irrupción de la modernidad en nuestro país, en razón de la consolidación durante medio siglo de un poder autocrático, controlado por el partido conservador y la Iglesia católica colombiana, a nombre de una ideología hispanista y confesional. Es en este período cuando se consolida en Colombia el poder cultural y simbólica del clero y la intolerancia política respecto al pensamiento de las luces y del socialismo. Así mismo, en la última fase de la hegemonía conservadora, durante los años 1920, se hizo ostensible el desfase entre, de un lado, la modernización económica y la industrialización y, de otro lado, la ausencia de modernidad social, cultural y política.

Racionalidad de la política exterior de la República Popular China en el siglo XXI: los casos de Ecuador y Perú en América Latina durante el período 2008-2011

OpenAIRE

Terán Samanamud, Germán Alexander

2012-01-01

Este trabajo tiene como objetivo principal el comprender y describir la racionalidad que sustenta, a inicios del siglo XXI, la definición de los objetivos y la estrategia de Política exterior china, aterrizando, al interior de la región de América Latina y el Caribe, en los casos de Ecuador y Perú. Con ese fin, se ha explorado, desde el marco teórico del realismo, la necesidad de maximización de seguridad de la República Popular China, inmersa, al igual que todos los demás Esta...

La familia católica obrera durante la Segunda República : el Círculo Católico de Obreros de Burgos

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Rafael Ibáñez Hernández

1997-01-01

Full Text Available El Circulo Católico de Obreros de Burgos, la principal institución del movimiento social católico en la ciudad, alcanza su quincuagésimo aniversario durante el período de la Segunda república con las mismas estructuras definidas en la Restauración. La inmunidad de la ciudad de Burgos a las sacudidas sociales y ala conflictividad sindical del período, así como el peso de los patronos y de la jerarquía eclesiástica en estas estructuras, impedirán el crecimiento del Círculo, supuestamente apolítico, y de los sindicatos católicos, supuestamente aconfesionales.The Catholic Workers Cicle of Burgos, the principal institutíon of the catholic social movement in the town, reached its fiftieth anniversary during the period of the Second republic with the same organizational structures defined in the Restauration time. The inmunity of Burgos to the social upheavals and to the trade-unionist conflict ot the period, as well as the weigth of the employers and the ecclesiastic hierarchy in these structures, wíl prevent the growth of the Circle, purportedly apolitical, and the Catholic Uníons, formally aconfessional.

Pratiques, objets et finalités de collaboration en lien avec l’intégration des tablettes numériques dans une école secondaire | Practices, Objects and Collaboration Purposes Related to the Integration of Digital Tablets in a High School

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Nadia Cody

2016-08-01

Full Text Available Bien que les technologies de l’information et de la communication (TIC occupent une place de plus en plus prépondérante, tant au sein de la société que de l’école (Anderson, 2010, on remarque que leur intégration en contexte scolaire représente encore un défi de taille (Underwood et Dillon, 2011. Selon certains auteurs (Portelance, 2011; Desgagné, 1997, la collaboration constituerait un vecteur pour transformer les pratiques éducatives. Comment la collaboration peut-elle contribuer à ce changement que représente l’intégration des TIC? Les résultats d’une recherche-action, menée depuis trois ans de concert avec une école secondaire ayant pour objectif d’intégrer la tablette numérique, permet de mettre en lumière des pratiques, des objets et des finalités de collaboration qui ont émergé entre les différents acteurs, favorisant ainsi l’implantation de cet outil technologique. Although Information and Communication Technologies (ICT play an increasingly predominant role (Anderson, 2010, their integration in school context is still a challenge (Underwood and Dillon, 2011. According to Portelance (2011 and Desgagné (1997, collaboration is one vector that can be used to transform educational practices. How can collaboration contribute to the ICT integration process into our schools? The results of an action research, conducted for three years along with a high school that aims to integrate digital tablet, allows to highlighting practices, objects and collaboration purposes that emerged between actors, therefore facilitating the implementation of this technological tool.

Analyse qualitative de l'intégration de l'éducation sexuelle des jeunes dans les médias audio-visuels à Kinshasa en République Démocratique du Congo.

OpenAIRE

Nsakala, Gabriel Vodiena; Coppieters, Yves; Kayembe, Patrick Kalambayi

2014-01-01

L'éducation sexuelle par les médias de masse contribue positivement à la prévention des infections sexuellement transmissibles (IST)/VIH et des grossesses précoces auprès des jeunes. L'objectifs de cette étude sont d'appréhender le niveau d'intégration de l'éducation sexuelle dans les émissions de santé à Kinshasa en République Démocratique du Congo et d'identifier les facteurs facilitant et limitant l'éducation sexuelle des jeunes dans les programmes audio-visuels congolais. Une triangulatio...

Entre el público y el privado. Un análisis comparativo de la cobertura de ciencia de los telediarios brasileños Repórter Brasil y Jornal Nacional

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Marina Ramalho

2014-01-01

Full Text Available Este estudio compara la cobertura de ciencia y tecnología de dos noticieros de televisión brasileños: Jornal Nacional, de la principal cadena privada del país, y Repórter Brasil, transmitido por una emisora pública. En el período analizado -abril 2009 a marzo 2010- el noticiero privado emitió más noticias de CyT y le dio mayor destaque. Los noticieros siguieron diferentes agendas de cobertura, aunque las cuestiones médicas y de salud han sido las más comunes. En ambos noticieros, el encuadre narrativo principal fue “nueva investigación”, las investigaciones nacionales fueron priorizadas y, entre los científicos entrevistados, las mujeres fueron minoría.

De mochila nas costas, reconstruindo as trilhas da revista Realidade e em busca de novas narrativas. Revista Campus Repórter-UnB

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Dione Oliveira Moura

2009-12-01

Full Text Available O artigo descreve a experiência de uma revista laboratório da Faculdade de Comunicação da Universidade de Brasília, revista Campus Repórter, lançada no ano de 2007, mas, vai além e problematiza, a partir de experiências concretas, o espaço de ensino-aprendizagem em produção de reportagens como um espaço para construção de (novas formas narrativas para o jornalismo impresso, especialmente o jornalismo de revista. Também descreve o modo de produção colaborativa da revista, a qual envolve estudantes de jornalismo, publicidade e desenho industrial, com supervisão de professores editores da área de reportagem, fotojornalismo e planejamento gráfico.Conclui que a experiência colaborativa na produção de uma revista laboratório soma resultados e que a revista tem trilhado um caminho que aponta para novas formas narrativas mais atentas à polissemia, assim como a perspectivas inovadores de narrar fatos cotidianos a partir de uma perspectiva mais contextual, com inspiração na revista Realidade (1966 a 1976.

El Sistema de Acreditación de Carreras de Grado del MERCOSUR (ARCU-SUR en la Facultad de Agronomía de la Universidad de la República - Uruguay

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Ernesto Domínguez Misa

Full Text Available Resumen: La participación en el ARCU-SUR, plantea en las carreras el debate sobre la calidad y su aseguramiento, así como la respuesta institucional a la misma. Irrumpen en la agenda temas derivados como el reconocimiento de títulos, la nueva institucionalidad, la relación público - privado y universidad - estado. Este artículo realizará una revisión sobre los fundamentos, resultados e impactos producidos en la Facultad de Agronomía de la Universidad de la República, Uruguay, por el Mecanismo Experimental de Acreditación de Carreras de Grado del MERCOSUR (MEXA y el Sistema de Acreditación ARCU-SUR, centrándose en los efectos derivados, pero explora retrospectivamente la evolución institucional en las políticas de evaluación .

Tradução Oral à Prima Vista na formação do intérprete: considerações pedagógicas

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Gloria Regina Loreto Sampaio

2017-12-01

Full Text Available A Tradução Oral à Prima Vista (TrPV é um elemento de relevância para a formação do intérprete e um componente essencial para o desempenho do futuro profissional em muitos ambientes de atuação. Consequentemente, a prática da TrPV se faz presente em cursos de formação bem estruturados. Neste escrito, após uma breve referência à natureza, complexidade e desafios impostos pela TrPV, e tendo como base uma vivência docente extensa da autora, será apresentada uma possível abordagem pedagógica, voltada à aquisição da competência em TrPV e a um desempenho de qualidade nessa modalidade híbrida, situada no espaço fronteiriço tradução escrita e tradução oral.

A construção do cidadão: os conteúdos escolares nas escolas públicas do Rio Grande do Sul na Primeira República

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Berenice Corsetti

2012-06-01

Full Text Available  No Rio Grande do Sul, na Primeira República, ocorreu expressiva expansão do ensino, num contexto de modificações sociais e domínio político do Partido Republicano Rio-Grandense. Os conteúdos escolares, nesse processo, foram utilizados pelos dirigentes corno instrumento de construção do cidadão rio-grandense dos novos tempos do capitalismo. A reorganização curricular e programática efetivada nas escolas públicas do Rio Grande do Sul, na Primeira República, possibilitou a adoção de um caráter científico e técnico na estruturação dos conteúdos, o que foi importante para a formação dos trabalhadores que se faziam necessários para a realidade capitalista que os republicanos desejavam consolidar. A construção do cidadão que interessava ao projeto dos positivistas exigiu que a escola, além de ensinar, educasse para a disciplina, para a produtividade e para os cuidados com a saúde. A preparação para o mercado incluiu instrumentos através dos quais os governantes gaúchos prepararam a juventude rio-grandense para a aceitação da lógica do capital.Palavras-chave: conteúdos escolares, reorganização curricular, capitalismo.   Abstract In Rio Grande do Sul, during the First Republic, there was na expressive expansion of teaching, in a context of social changes and political rule by the Rio-Grandense Republic Party. The educational subjects, in this course, were used by the directors as a way to prepare the citizen of Rio Grande do Sul for the new ages of capitalismo The curricular and program reorganization which took place at the publics schools of Rio Grande do Sul, during the First Republic, allowed the adoption of scientific and technical character in the struturation of the subjects, which was important for the creation of workers who would be necessary for the capitalist reality that republicans wanted to consolidate. The formation of the citizen which was of interest for the project of the positivists demanded

“La influencia de la masonería madrileña en la política de la Segunda República Española (1931-1939”

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Manuel Según-Alonso

2014-01-01

Full Text Available Las criticadas interconexiones entre masonería y política en Madrid (España deben abordarse desde diferentes puntos de vista, puesto que nos encontramos ante una institución compleja, estructurada en varios niveles de acción: masones, logias y Obediencias. Además, a la masonería madrileña se le ha atribuido objetivos partidistas como la lucha contra el poder de la dictadura, el clero y la monarquía; y a favor de una sociedad laica y democrática; así como un fuerte compromiso social. Hemos intentado explicar, dentro del contexto madrileño, el vínculo entre masonería y política (republicanismo que hace que se cree un grupo ideológico de presión dentro de la masonería madrileña en la República Española (1931-1939.

Direito à liberdade e à segurança no Estado de Direito Democrático: os limites da atuação policial - uma perspetiva jurídico-constitucional da Polícia da República de Moçambique

OpenAIRE

Chau, Ruth Armando

2017-01-01

O Estado de direito democrático implica o reconhecimento dos direitos fundamentais constitucionalmente consagrados e, consequentemente, a subordinação do Estado e de todos os organismos que o compõem, à Constituição e à legalidade democrática. Os direitos fundamentais constituem o fundamento de qualquer Estado de direito democrático e Moçambique não deve ser exceção. Moçambique é uma República e um Estado de direito organizado democraticamente e respeitador dos direitos, liberdades e garantia...

Implementación de la Estrategia y Plan de Acción de eSalud en la República Argentina, 2011 - 2013

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Myrna Marti

2014-06-01

Full Text Available Como resultado de la aprobación de la Estrategia y Plan de Acción Regional de eSalud de la Organización Panamericana de la Salud (OPS/Organización Mundial de la Salud (OMS en 2011, en la República Argentina se desarrolló un proyecto de cooperación técnica entre la Representación de la OPS, la OMS y el Ministerio de Salud de la Nación que tiene como objetivo incorporar la estrategia a nivel nacional. Para ello, se desarrollaron una serie de reuniones, documentos y actividades entre las cuales se destacan la realización de un mapeo de iniciativas de eSalud en el país que incorporan tecnologías de la información y la comunicación (TIC en salud, identificación y selección de experiencias exitosas en eSalud, fomento de la cooperación horizontal, programa de colaboración virtual, programa de alfabetización digital y taller de eSalud. Los resultados obtenidos en este proceso se relacionan con el cumplimiento de los cuatro objetivos estratégicos de la Estrategia y Plan de Acción de eSalud de la OPS/OMS.

Improving the security of electricity supply - report by a rapporteur ad int

International Nuclear Information System (INIS)

Forsten, J.; Lehtonen, M.

2002-07-01

The storms 'Pyry' and 'Janika', which swept over Finland in October-November 2001, caused serious damages to the operability of electric systems and led to long-term and extensive interruptions in electricity supply especially in Pirkanmaa, Central Home, Poijat-Hame and in the Uusimaa region. Although the security of electricity supply in Finland has in general been on a high level, the needs of customers concerning the quality of electrical power are constantly growing, and the operational reliability of the distribution networks will thereby have to be developed. The Rapporteur ad int. appointed by the Ministry of Trade and Industry on 21 November 2001 considers that such a scheme complementing the price reduction under the Electricity Market Act should be set up that would require a fixed compensation from the distribution network operators in the case of non deliverance of electricity. The fixed compensation should be paid automatically for e.g. interruptions lasting over 12 hours. The sum would depend on the length of the interruption and on the customer's annual rate of the network service fee. The Rapporteur also gives a number of other recommendations for improving the situation. Each distribution network operator is to choose the means of improvement on a technical-economical basis. The required level in the design, construction, operation and maintenance of an electrical network should guarantee that the interruptions in electricity supply would not exceed six hours even in exceptional circumstances. Ensuring electrical safety is of prime importance in disturbance situations. Shortening the interruption times and improving the quality of electricity call for sustained investment planning and activities. The distribution network operators should draw up a ten-year action plan. including measures aiming to reduce interruptions and the related timetables. To be able to keep the interruption times short in extensive cases of disturbance, the distribution

"Det är inte mig det är fel på, det är huset" : en studie av prognosfaktorer och bemötande med fokus på sjuka hus-syndromet

OpenAIRE

Edvardsson, Berit

2015-01-01

Bakgrund: Sick Building Syndrome, SBS, är fortfarande 2015 ett tillstånd som vållar mycket diskussion. Symtomen kan grupperas i slemhinnesymtom, hudsymtom och allmänna symtom. I definitionen ingår att personen/ personerna som fått symtom har exponerats för dålig inomhusluft i en speciell byggnad. När personen inte är i byggnaden så förbättras eller försvinner symtomen. Många olika faktorer kan orsaka eller medverka till uppkomst eller försämringar av SBS-symtom, som t.ex. luftens innehåll av ...

La política económica de la República Popular China: un desafío a la hegemonía monetaria de los Estados Unidos en el Sudeste Asiático. Periodo 2003 -2015

OpenAIRE

Benavides Niño, David Leonardo

2016-01-01

La presente investigación parte del declive de la hegemonía de los Estados Unidos y el paralelo asenso económico de la República Popular China en las últimas décadas. De este modo, se plantea como objetivo principal analizar cómo China mediante su política económica desafía a la hegemonía monetaria de los Estado Unidos en el Sudeste Asiático, durante el periodo de 2003 a 2015. Con el fin de lograr este objetivo, se elabora un estudio de la hegemonía de los Estados Unidos y sus dinámicas en e...

Modeling of Soil Erosion by IntErO model: The Case Study of the Novsicki Potok Watershed, of the Prokletije high mountains of Montenegro

Science.gov (United States)

Spalevic, Velibor; Al-Turki, Ali M.; Barovic, Goran; Leandro Naves Silva, Marx; Djurovic, Nevenka; Soares Souza, Walisson; Veloso Gomes Batista, Pedro; Curovic, Milic

2016-04-01

The application of soil conservation programs to combat erosion and sedimentation are significantly contributing to the protection of the natural resources. Watershed management practices include the assessment of Physical-Geographical, Climate, Geological, Pedological characteristics, including the analysis of Land Use of the regions concerned. The policy makers are increasingly looking for the different land uses and climatic scenarios that can be used for valuable projections for watershed management. To increase knowledge about those processes, use of hydrological and soil erosion models is needed and that is allowing quantification of soil redistribution and sediment productions. We focused on soil erosion processes in one of Northern Montenegrin mountain watersheds, the Novsicki Potok Watershed of the Polimlje River Basin, using modeling techniques: the IntErO model for calculation of runoff and soil loss. The model outcomes were validated through measurements of lake sediment deposition at the Potpec hydropower plant dam. Our findings indicate a medium potential of soil erosion risk. With 464 m³ yr-1 of annual sediment yield, corresponding to an area-specific sediment yield of 270 m³km-2 yr-1, the Novsicki Potok drainage basin belongs to the Montenegrin basins with the medium sediment discharge; according to the erosion type, it is surface erosion. The value of the Z coefficient was calculated on 0.403, what indicates that the river basin belongs to 3rd destruction category (of five). Our results suggest that the calculated peak discharge from the river basin was 82 m3s-1 for the incidence of 100 years. According to our analysis there is a possibility for large flood waves to appear in the studied river basin. With this research we, to some extent, improved the knowledge on the status of sediment yield and runoff of the river basins of Montenegro, where the map of Soil erosion is still not prepared. The IntErO model we used in this study is relatively

Reactive Energetic Plasticizers Utilizing Cu-Free Azide-Alkyne 1,3-Dipolar Cycloaddition for In-Situ Preparation of Poly(THF-co-GAP-Based Polyurethane Energetic Binders

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Mingyang Ma

2018-05-01

Full Text Available Reactive energetic plasticizers (REPs coupled with hydroxy-telechelic poly(glycidyl azide-co-tetrahydrofuran (PGT-based energetic polyurethane (PU binders for use in solid propellants and plastic-bonded explosives (PBXs were investigated. The generation of gem-dinitro REPs along with a terminal alkyne stemmed from a series of finely designed approaches to not only satisfy common demands as conventional energetic plasticizers, but also to prevent the migration of plasticizers. The miscibility and rheological behavior of a binary mixture of PGT/REP with various REP fractions were quantitatively determined by differential scanning calorimetry (DSC and rheometer, respectively, highlighting the promising performance of REPs in the formulation process. The kinetics on the distinct reactivity of propargyl vs. 3-butynyl species of REPs towards the azide group of the PGT prepolymer in terms of Cu-free azide-alkyne 1,3-dipolar cycloaddition (1,3-DPCA was studied by monitoring 1H nuclear magnetic resonance spectroscopy and analyzing the activation energies (Ea obtained using DSC. The thermal stability of the finally cured energetic binders with the incorporation of REPs indicated that the thermal stability of the REP/PGT-based PUs was maintained independently of the REP content. The tensile strength and modulus of the PUs increased with an increase in the REP content. In addition, the energetic performance and sensitivity of REP and REP triazole species was predicted.

Nationalism, regionalism and autonomy during the Second Republic | Nacionalismos, regionalismos y autonomía en la Segunda República

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Justo Beramendi González

2003-12-01

Full Text Available The Second Republic introduced a number of innovations as a means of surmounting the main factors of social and political backwardness which had beset the country since the beginning of the liberal revolution in the Þ rst third of the nineteenth century. Prominent among these factors was the emergent plurality of different nations within the State, a phenomenon which had spread following the birth and rapid growth of Catalan and Basque nationalism, and to a much lesser extent, the weak Galician nationalist movement, as well as other marginal momentary upsurges. The aim of this article is to provide a succinct analysis of the changing relationship between the nationalist issue and the structure of the State during this period. | La Segunda República trajo consigo varias innovaciones que pretendían superar, en sentido modernizador, los principales factores de atraso social y político que había venido padeciendo el país desde los inicios de la revolución liberal en el primer tercio del siglo XIX. Entre estos factores, cabe destacar la emergente plurinacionalidad del Estado, que se había ido ensanchando con el nacimiento y rápido desarrollo de los nacionalismos catalán y vasco y, en mucha menor medida, del débil nacionalismo gallego y de otros brotes de momento marginales. El objeto de este artículo es analizar muy sintéticamente cómo evoluciona la relación entre cuestión nacional y estructura del Estado en este período.

Impact des matériaux biosourcés sur le climat intérieur : Un outil de calcul flexible à l'échelle de la pièce

OpenAIRE

Dubois, Samuel; Lebeau, Frédéric

2014-01-01

L'impact de l'utilisation de matériaux d'origine végétale sur le climat intérieur, et donc sur le confort des occupants ainsi que la performance énergétique du bâtiment, n'est établi que partiellement. Ces produits présentent des propriétés hygroscopiques et capillaires causant des phénomènes spécifiques liés aux changements de phase dynamiques au sein de la matrice poreuse. Les modèles mathématiques utilisés pour étudier leur comportement hygrothermique de manière détaillée sont souvent des ...

Le lac Titicaca: histoire perdue d'une mer intérieure

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1992-01-01

Full Text Available Cet article tente de reconstruire l’histoire de la région du lac Titicaca et de son peuplement pour la période précédant l’arrivée des espagnols. Á cet effet, nous avons utilisé une approche multidisciplinaire (sédimentologie, archéologie, mythologie qui autorise, depuis l’amont et dans la longue durée, un nouvel éclairage des données historiques du XVIe siècle. Malgré les changements climatiques et politiques ayant affecté les rives du Titicaca avant la Conquête espagnole, il existe une continuité historique qui va de la civilisation de Pukará à Hatuncolla en passant par Tiwanaku. Si la documentation espagnole ne rend pas compte de l’importance des anciennes populations riveraines et notamment des pukinas, c’est qu’il était de l’intérêt des envahisseurs successifs (aymaras, incas, espagnols de l’occulter. EL LAGO TITICACA: HISTORIA PERDIDA DE UN MAR INTERIOR. Este artículo constituye un intento de reconstrucción de la historia del lago Titicaca y de su poblamiento por el período que precede la llegada de los españoles. En esta perspectiva, hemos utilizado una aproximación multidisciplinaria (sedimentología, arqueología, mitología que autoriza una nueva lectura de las fuentes históricas del siglo XVI, a partir de datos remotos y en la larga duración. A pesar de los cambios climáticos y políticos que afectaron las orillas del Titicaca antes de la Conquista española, existe una continuidad histórica que va de la cultura de Pukará hasta Hatuncolla (pasando por Tiwanaku. Si la documentación española no toma en cuenta la importancia de las antiguas poblaciones lacustres, particularmente los pukinas, es porque el interés de sus sucesivos vencedores (aymara, incas, españoles era de ocultarla. THE TITICACA LAKE: HISTORY LOST IN THE CENTER OF A DEEP IMMENSITY. This article comprises an attempt to reconstruct the Titicaca Lake history and its colonization during the period preceding the Spanish arrival. On

La science comme pratique d’intégration dans la société des princes. Les Grimaldi de Monaco et la curiosité savante (xviie–xviiie siècle)

OpenAIRE

Thomas Fouilleron

2011-01-01

Jusque-là seigneur de Monaco, Honoré II (1597-1662) prend, en 1612, le titre de prince. En 1641, il se place sous la protection du roi de France qui confirme, par le traité de Péronne, sa souveraineté. Parallèlement à son effort d’affirmation politique, il s’attache à intégrer la société européenne des princes en adoptant les pratiques culturelles de la distinction monarchique.Souverains à Monaco et grands aristocrates en France, les Grimaldi constituent, au xviie siècle, des cabinets de curi...

La incidencia del maltrato intrafamiliar infantil en la violencia física, verbal y psicológica ejercida entre los estudiantes de los quinto años de educación general básica de la Unidad Educativa República del Ecuador

OpenAIRE

Calle Suáres, María Fernanda

2016-01-01

El objetivo de la presente investigación esdiagnosticar la incidencia del maltrato intrafamiliar infantil en la violencia física, verbal y psicológica ejercida entre los estudiantes de los quintos años de educación general básica de la Unidad Educativa República del Ecuador, perteneciente al cantón Cuenca, período lectivo 2014-2015. El enfoque del estudio fue cuali-cuantitativo y de corte descriptivo. La población investigada se constituyó por 129 alumnos y alumnas de edades que oscilan entre...

Intégrer la notion d’équité : création d'un cadre d'action pour placer la mobilisation du savoir et l’équité en santé au coeur des rapports sur l’état de santé des populations

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Lesley Ann Dyck

2018-01-01

Full Text Available Les centres de collaboration nationale en santé publique (CCNSP ont collaboré à l’élaboration d’un cadre d’action visant à intégrer la notion d’équité dans les rapports sur l’état de santé des populations (RESP. Ce cadre d’action rassemble les comptes rendus de recherche et une expérience de terrain fondée sur une approche originale d’apprentissage collaboratif faisant appel aux praticiens en santé publique du Canada. Dans cet article, nous présentons le cadre d’action, nous décrivons le processus d’apprentissage et nous situons les RESP au sein des travaux en cours dans le secteur de la santé publique. Nous analysons ensuite la nature des données probantes sur les déterminants sociaux de la santé à titre de dimension clé pour déterminer sur quoi portent les rapports et comment ces données y sont intégrées. Enfin, nous établissons le lien entre les données et la mise en oeuvre en explorant le concept de renseignements exploitables et en détaillant le cadre d’action visant à intégrer la notion d’équité dans les RESP. Nous concluons sur l’importance de placer la mobilisation du savoir au coeur du processus d’élaboration des RESP et nous apportons des suggestions pour les prochaines étapes. Notre objectif est d’encourager les praticiens à utiliser le cadre d’action, à en discuter et, ultimement, à le renforcer.

New Comment on Gibbs Density Surface of Fluid Argon: Revised Critical Parameters, L. V. Woodcock, Int. J. Thermophys. (2014) 35, 1770-1784

Science.gov (United States)

Umirzakov, I. H.

2018-01-01

The author comments on an article by Woodcock (Int J Thermophys 35:1770-1784, 2014), who investigates the idea of a critical line instead of a single critical point using the example of argon. In the introduction, Woodcock states that "The Van der Waals critical point does not comply with the Gibbs phase rule. Its existence is based upon a hypothesis rather than a thermodynamic definition". The present comment is a response to the statement by Woodcock. The comment mathematically demonstrates that a critical point is not only based on a hypothesis that is used to define values of two parameters of the Van der Waals equation of state. Instead, the author argues that a critical point is a direct consequence of the thermodynamic phase equilibrium conditions resulting in a single critical point. It is shown that the thermodynamic conditions result in the first and second partial derivatives of pressure with respect to volume at constant temperature at a critical point equal to zero which are usual conditions of an existence of a critical point.

Periodistas precarios en el interior de la república mexicana: atrapados entre las fuerzas del mercado y las presiones de los gobiernos estatales

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Germán Espino Sánchez

2016-01-01

Full Text Available Los reportes emitidos sobre diversas entidades de la rep blica mexicana con rman que, a pesar de que se efect an elecciones competitivas en todos los estados, la intervenci n de los gobiernos estatales en los medios locales sigue siendo la norma. Los periodistas cuentan con contratos muy precarios y el gobierno del estado tiene mayor oportunidad de cooptar su l nea editorial a cambio de recursos econ micos. Esta investigaci n muestra c mo los periodistas de medios locales siguen desarrollando una l nea editorial o cialista, igual que en la poca del autoritarismo, y analiza su situaci n a partir de las variables profesionalizaci n de los periodistas e intervenci n de los gobiernos estatales en los medios de comunicaci n locales . Para esta investigaci n se elabor un estudio de caso sobre el estado de Quer taro; se entrevist a periodistas y a exfuncionarios de gobierno; se realiz un an lisis de contenido y se recopilaron fuentes secundarias que describen las relaciones entre los gobernadores y los medios locales de M xico. El an lisis de los datos sugiere que el estado de Quer taro puede ser un ejemplo del control que ejercen los gobernadores sobre los medios locales.

Modos de fazer uma República: demiurgia e invenção institucional na tradição republicana brasileira Ways of republic making: institutional invention in Brazilian republican tradition

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Renato Lessa

2012-07-01

Full Text Available O artigo sugere uma interpretação da República brasileira como ­processo de invenção dependente de duas ordens de ficções. A primeira delas, formulada entre outros ensaístas brasileiros, por Francisco José de Oliveira Vianna, sustenta a vigência, no processo de constituição da sociedade e do Estado no ­Brasil desde o período colonial, de um padrão de sociabilidade fragmentado e carente de laços sociais e cívicos permanentes. A segunda ordem de ficções é corolário da primeira: a ausência de nexos sociais acabou compensada pela presença e pela força do direito público e da elaboração constitucional. O artigo analisa dois momentos cruciais de (reinvenção da República brasileira, ambos marcados pelo predomínio do direito público e da invenção constitucional (1932 e 1988. Ao fim, a experiência política brasileira é apresentada como tentativa continuada de criação de uma comunidade cívica e política “contra os factos”.This article suggests an interpretation of the Brazilian republican State and nation building as a process affected by two orders of fictions. The first and fundamental one was formulated, among several Brazilian intellectuals, by Francisco José de Oliveira Vianna in the beginning of the twentieth century. It was based on the assumption that Brazilian social and political history has been marked, since colonial times, by “insolidarism” and by a lack of social and civic bonds among the population. The second order of fictions is a corollary of the first: the lack of social bonds has been compensated for by the presence and the force of public law and constitution making. The article analyzes two crucial moments of (reinvention of the Brazilian Republic - 1932 and 1988 - marked by a clear predominance of constitution and law making. As a result, Brazilian political experience is presented as an everlasting attempt to build a civic and political community against the facts.

Comparison of a Commercially Available Repetitive-Element PCR System (DiversiLab) with PCR Ribotyping for Typing of Clostridium difficile Strains ▿

OpenAIRE

Eckert, C.; Van Broeck, J.; Spigaglia, P.; Burghoffer, B.; Delmée, M.; Mastrantonio, P.; Barbut, F.

2011-01-01

This study compared a repetitive-element PCR (rep-PCR) method (DiversiLab system) to PCR ribotyping. The discriminatory power of rep-PCR was 0.997. Among the PCR ribotype 027 isolates tested, different rep types could be distinguished. rep-PCR showed a higher discriminatory power than PCR ribotyping. Nevertheless, this method requires technical skill, and visual interpretation of rep-PCR fingerprint patterns may be difficult.

Etude sur l'utilisation des réseaux sociaux en bibliothèque universitaire: le cas de l'intégration de la Bibliothèque de l'EPFL

OpenAIRE

Wagnières, Flore; Rezzonico, Ariane

2012-01-01

Dans une société où les réseaux sociaux prennent de plus en plus d’importance dans la vie de tous les jours, la Bibliothèque de l’École polytechnique fédérale de Lausanne (EPFL) a souhaité étudier les possibilités de s’intégrer sur ces plateformes afin de mieux s’adapter à ces utilisateurs aux pratiques numériques envahissantes. Dans ce travail j’ai essayé de saisir les différents enjeux des réseaux sociaux pour une bibliothèque ainsi que de comprendre l’évolution technologique qui a mené à c...

Gestión de riesgos para la adopción de la computación en nube en entidades financieras de la República Argentina

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María de los Ángeles López

2014-01-01

Full Text Available Las infraestructuras tecnológicas dinámicas, entre ellas la computación en nube, representan una nueva alternativa de tecnología de información disponible para administrar las ac- tividades de las organizaciones, en particular en aquellas que hacen un uso intensivo de la información, como las entidades financieras. Al analizar la utilización de estas arquitecturas es fundamental considerar los nuevos riesgos a los que se expo- nen los entes; esto permite desarrollar estrategias de gestión destinadas a identificarlos, evaluarlos y buscar el modo de minimizar sus efectos. En este sentido son útiles herramientas como la risk breakdown structure (RBS, una estructura de je- rarquización de fuentes de riesgos que simplifica y sistematiza el análisis. En este trabajo se pretende diseñar una RBS para la identificación y descripción jerárquica de las fuentes de ries- gos vinculados a la implementación de la computación en nube en entidades financieras, basándose en la normativa del Banco Central de la República Argentina.

Lectura digital en la competencia lectora: La influencia en la Generación Z de la República Dominicana

Directory of Open Access Journals (Sweden)

2017-07-01

Full Text Available La mayoría de los países latinoamericanos están focalizados en elevar la calidad de los aprendizajes mediante la dotación de recursos tecnológicos a los centros educativos como si su mera presencia bastara para desarrollar las competencias fundamentales del siglo XXI. La lectura digital no es un fin en sí mismo, es un medio a disposición del usuario que la selecciona según sus propósitos y las utiliza en contextos socioculturales específicos. Los adolescentes acceden a Internet, al menos con cuatro fines: académicos, recreativos, para participar en la sociedad y comunicarse. Este estudio describe dichos fines en jóvenes de la República Dominicana y lo relaciona con el nivel de competencia lectora en dos contextos educativos, escuelas públicas y privadas. La muestra está compuesta por 382 estudiantes de cuarto de Secundaria. Se aplicaron dos instrumentos: CoLeP, basado en los textos liberados de PISA y una Escala de Práctica de Lectura, que clasifica los cuatros fines de lectura en dos formatos, impreso o digital. La conclusión es que casi todos los estudiantes acceden a Internet y lo utilizan para fines académicos sin importar el sector educativo, sin embargo, el nivel de competencia lectora difiere significativamente, ubicándose los estudiantes de las escuelas públicas en los niveles más bajos, lo que resta oportunidades a sectores socialmente más vulnerables y produce neoanalfabetos con altos costos económicos para la nación.

Categorización del estado de conservación de las lagartijas y anfisbenas de la República Argentina

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Quinteros, Andrés Sebastián

2012-11-01

Full Text Available Luego de la elaboración de la primera lista roja de la herpetofauna de la República Argentina, realizada en el año 2000, son numerosos los cambios y estudios efectuados en los diferentesgrupos de saurios de la Argentina. Si bien hay avances realizados en todas las ramas de la biología relacionadas a las lagartijas, los progresos taxonómicos y ecológicos son los más evidentes. Debido a estos progresos, y a la implementación de sustanciales modificaciones conrespecto a la metodología que se utilizara en el año 2000, un grupo de veintisiete especialistas de diferentes instituciones académicas de la Argentina aportaron información biológica, ecológica, geográfica y taxonómica en un taller que permitió reevaluar el estado de conservación de las 256 especies de lagartijas y anfisbenas de la Argentina. Los resultados obtenidos indicanque setenta y ocho especies se encuentran incluidas en la lista roja (una En Peligro, nueve Amenazadas y 68 Vulnerables, 31 Insuficientemente Conocidas y 147 No Amenazadas. Con respecto a la categorización anterior de la AHA, se agregaron 94 especies, de las cuales 87 son nuevos taxa, cuatro revalidadas, y otras tres especies fueron incorporadas a la fauna argentina. Asimismo cinco especies fueron extraídas del listado de la fauna de la República Argentina. En comparación con los resultados obtenidas en la categorización del año 2000, observamos que el número de especies Amenazadas se incrementó de cinco a nueve especies y de siete a 68 especies como Vulnerable, incluyendo a los géneros Phymaturus y Anisolepis. Asimismo, se categorizó como Insuficientemente Conocida a 31 especies contra 108 del año 2000. Estos resultados son en parte debido al incremento en el conocimiento sistemático, biológico, ecológico y biogeográficos de las lagartijas y anfisbenas de la Argentina, por el cambio radical de la metodología utilizada y también por los efectos de la presión antrópica sobre las especies

Arquitetura óptica: análise de um modelo de associação de espelhos cilíndricos como representação dos prédios da Procuradoria Geral da República

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Jair Lúcio Prados Ribeiro

2015-05-01

Full Text Available http://dx.doi.org/10.5007/2175-7941.2015v32n3p837 Os dois prédios da Procuradoria Geral da República em Brasília possuem formato cilíndrico e são cobertos por vidros refletores, assemelhando-se a uma associação de dois espelhos convexos cilíndricos. A partir de um modelo experimental usando duas lixeiras cilíndricas cromadas, é discutida a formação da imagem de um prédio por reflexão no outro e as aberrações ópticas presentes. O artigo busca mostrar um possível diálogo entre as disciplinas da arquitetura e da física, o qual é raro na literatura acadêmica.

Étude sur l'utilisation des réseaux sociaux en bibliothèque universitaire : le cas de l'intégration de la Bibliothèque de l'EPFL

OpenAIRE

Wagnières, Flore

2012-01-01

Dans une société où les réseaux sociaux prennent de plus en plus d’importance dans la vie de tous les jours, la Bibliothèque de l’École polytechnique fédérale de Lausanne (EPFL) a souhaité étudier les possibilités de s’intégrer sur ces plateformes afin de mieux s’adapter à ces utilisateurs aux pratiques numériques envahissantes. Dans ce travail j’ai essayé de saisir les différents enjeux des réseaux sociaux pour une bibliothèque ainsi que de comprendre l’évolution technologique qui a mené à c...

Thobie Jacques, Les Intérêts culturels français dans l’Empire ottoman finissant. L’enseignement laïque et en partenariat, Peeters, Leuven, 2009, 461 p.

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Caroline Piquet

2010-09-01

Full Text Available À l’heure où la France cherche à relancer sa politique culturelle au Moyen-Orient avec l’implantation d’universités et de lycées prestigieux, l’ouvrage de Jacques Thobie vient nourrir la réflexion sur le rôle de l’éducation dans les processus d’expansion politique et le jeu des puissances. Jacques Thobie publie ici le complément à sa thèse désormais célèbre, Intérêts et impérialisme français dans l’Empire Ottoman 1895-1914. L’ouvrage n’est que la première partie d’un travail sur l’enseignemen...

Comments on Triassi et al. Environmental Pollution from Illegal Waste Disposal and Health Effects: A Review on the “Triangle of Death”. Int. J. Environ. Res. Public Health 2015, 12, 1216–1236

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Maurizio Bifulco

2015-03-01

Full Text Available A recent paper was published on Int. J. Environ. Res. Public Health addressing the so-called “Triangle of Death” linked to waste crisis in the Southern Italy [1]. Three decades of illegal waste management including uncontrolled disposal of toxic and industrial material, land filling and unauthorized incineration have transformed these Italian areas, into the poisoned dustbin of the country, the “Triangle of Death” also called “Land of Fires” [2,3], characterized by the presence of a widespread organized crime, a huge social and economic disintegration, a high population density with large migration flows. [...

Análisis de la satisfacción del turista de paquetes turísticos respecto a las actividades de ocio en el destino: el caso de República Dominicana

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Sergio Moreno Gil

2002-01-01

Full Text Available El presente trabajo analiza el nivel de satisfacción de los clientes que viajan por medio de un paquete turístico ofertado por un turoperador. Se estudian los diferentes servicios relacionados con las actividades de ocio y el proceso de disfrute del tiempo libre en el destino; disponiéndose así de la satisfacción obtenida respecto a los principales componentes de estos servicios y sus implicaciones. En este sentido, se ha desarrollado un estudio empírico a través de 956 entrevistas personales realizadas en el destino de República Dominicana, y llevadas a cabo en sus dos principales zonas turísticas: Puerto Plata y Punta Cana. Finalmente, se comentan las revelaciones más destacadas de este trabajo empírico, resaltando que existen importantes diferencias significativas respecto a la satisfacción de los clientes entre los distintos atributos de servicio prestado por el turoperador en el destino.

Investigación sobre la vivienda rural en el nordeste de la República Argentina y propuesta para el déficit actual

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Sartorio, Roberto

1984-06-01

Full Text Available OBJECTIVES — Generation of a prototype Rural House in the northeastern region of the Argentine Republic. — An attempt will be made for the house to be of a progressive nature» that is to say» that it may be built using the system of private endeavor and have sufficient flexibility to enable it to keep pace with the developmental needs of the family. — To achieve maximum development of the house with a minimum of resources (more with less. — Improvement in the standard of living enabling the rural exodus to be reverted. — To generate conditions for new settlements in regions close to the border.OBJETIVOS Generación de una Vivienda Rural prototípica en la región nordeste de la República Argentina. — Se buscará que la vivienda tenga un carácter progresivo» o sea, que pueda ser construida por el sistema de esfuerzo propio y tenga la flexibilidad suficiente que permita acompañar las necesidades de desarrollo de la familia. — Lograr el máximo desarrollo de la vivienda con el mínimo de los recursos (más con menos. — Mejoramiento de la calidad de vida que permita revertir el éxodo rural. — Generar condiciones para nuevos asentamientos en zonas de fronteras.

O papel do intérprete de libras no contexto da educação inclusiva: problematizando a política e a prática

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Joelma Remígio de Araújo

2017-02-01

Full Text Available Este é um estudo qualitativo de caráter etnográfico sobre as políticas educacionais inclusivas para surdos, no tocante à presença do Intérprete de Língua de Sinais (ILS no espaço de escolarização. Tratamos deste assunto por entendermos ser este profissional de fundamental importância para a educação de surdos, considerando também o momento histórico, em que teve reconhecida sua profissão, a partir de uma lei específica. Assim, entendendo que cada vez mais se reveste de importância a atuação deste profissional, buscamos, por meio da presente pesquisa, observar como ele está atuando nas escolas inclusivas e quais as consequências desta atuação na escolarização dos surdos.

Structural characterization and antioxidant property of released exopolysaccharides from Lactobacillus delbrueckii ssp. bulgaricus SRFM-1.

Science.gov (United States)

Tang, Weizhi; Dong, Mingsheng; Wang, Weilu; Han, Shuo; Rui, Xin; Chen, Xiaohong; Jiang, Mei; Zhang, Qiuqin; Wu, Junjun; Li, Wei

2017-10-01

Three released exopolysaccharide fractions (r-EPS1, r-EPS2 and r-EPS3) were isolated from the fermented milk of Lactobacillus delbrueckii ssp. bulgaricus SRFM-1 and purified by anion exchange chromatography, and characterizations of the structures were conducted. The r-EPS1 and r-EPS2 were homogenous with the average molecular weights of 3.97×10 5 Da and 3.86×10 5 Da, respectively. Three r-EPS fractions were composed of galactose and glucose with a molar ratio of 1.23: 1.00, 1.33: 1.00 and 1.00: 1.34, respectively. Structural characterization indicated that the r-EPS1 contained a backbone of →6-β-d-Galp-(1→4)-β-d-Glcp-(1→4)-α-d-Galp-(1→4)-β-d-Galp-(1→6)-β-d-Galp-(1→4)-β-d-Glcp-(1→4)-α-d-Galp-(1→4)-β-d-Galp-(1→4)-α-d-Glcp-(1→, and had three branching points which existed in terminal with D-Glcp residues with α/β-d-(1→6) linkages. The r-EPS2 was composed of →6-β-d-Galp-(1→4)-β-d-Glcp-(1→6)-α-d-Galp-(1→ as the backbone chain with a branching point which also existed in terminal D-Glcp residue with β-(1→6) linkage. In addition, three r-EPS fractions exhibited strong scavenging activities on superoxide radical, hydroxyl radical, DPPH radical and chelating activity on ferrous ion, and their antioxidant activities decreased in the order of r-EPS1>r-EPS2>r-EPS3. Copyright © 2017 Elsevier Ltd. All rights reserved.

Proyectos de parcelas con servicios desarrollados por el INVI en la República Dominicana

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Pou Howley, Carlos

1984-07-01

Full Text Available Santo Domingo, the capital of the Dominican Republic, has not escaped the phenomenon of urban growth and the concentration of large slum areas or hovels, mainly due to the migratory movements of the peasants who have been driven from the country. As a viable solution to the enormous problem of housing in this city, INVI, with the participation of the World Bank, is putting forward projects for lots supplied with services in which infrastructure services are installed on urban land and plots or parcels of land are given to families so that they can build or complete their houses. These projects are located in places registering a greater tendency towards development. The urban plan formulated in both projects is of an eminently pedestrian nature with a reduced thoroughfare for vehicles. In the pedestrian precinct, it was possible to lay down what have been called mini-parks, which involve widening the pedestrian thoroughfare and, in addition to constituting green areas distributed throughout the projects, they also reinforce the idea of a neighbourhood. Because of the scope of the projects, a series of installations have been provided to maintain their own community services, as well as commercial and institutional ones, which are distributed strategically.Santo Domingo, capital de la República Dominicana, no ha escapado al fenómeno del crecimiento urbano y a la concentración de grandes tugurios o arrabales, debido principalmente a los movimientos migratorios de los campesinos expulsados del campo. Como una solución viable al gran problema de la vivienda de esta ciudad, el INVI, con la participación del Banco Mundial, plantea proyectos de parcelas con Servicios en los cuales se instalan servicios de infraestructura en tierras urbanas y se proporcionan parcelas o solares a familias para que éstas construyan o completen sus viviendas. Se ubican estos proyectos en sitios que acusan una mayor tendencia de desarrollo. El esquema urbano

Poder local y democracia municipal durante la Segunda República a través de los Ayuntamientos: el caso de Villablanca (Huelva

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Juan Ignacio González Orta

2010-11-01

Full Text Available El presente artículo pretende, desde la historia local, abordar el estudio del comportamiento de los ayuntamientos republicanos y su relación con la agitada vida política provincial. Se trata, en esencia, de analizar el funcionamiento del poder político municipal, así como los mecanismos de los que se hizo uso para controlar la ya de por sí estrecha autonomía de los ayuntamientos andaluces. El estudio del acceso al poder y la lucha por su control en el caso de Villablanca (Huelva constituye un buen ejemplo de la influencia que en estas dinámicas ejercieron, en última instancia, los gobernadores civiles.Palabras Clave: Segunda República, gobernadores civiles, ayuntamientos, poder local, Villablanca. ___________________________________ABSTRACT:The present article pretends, from the local history, to raise the republic council’s behavior and its relation with the political provincial hectic life. In essence, it would be about analyzing the local political power, as well as the mechanisms that were used to control the already in itself strengthen autonomy of Andalusia councils. The access’s study and the struggle for its control in the case of Villablanca (Huelva represent a good example of the influence that they exert in this dynamics, as a last resort, the civil governors.Keywords: Spanish Second Republic, civil governors, councils, local power, Villablanca.

La resurrección retórica de la República en 1890: Un análisis sobre las relaciones entre elocuencia, oratoria y política en la Argentina a fines del siglo XIX

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Leonardo D. Hirsch

Full Text Available El trabajo tiene como objetivo hacer un análisis de las relaciones entre retórica, oratoria y política en la Argentina, a lo largo del siglo XIX, en general, y durante la crisis de 1890, en particular. En este sentido creemos que en la particular coyuntura de 1890 se temió sobre todo por la desintegración del cuerpo político de la República como consecuencia de la creciente indiferencia de los ciudadanos por la cosa pública. Los Cívicos, en consecuencia, decidieron emprender una "campaña de regeneración", fundada sobre la creencia en el "poder soberano de la palabra", y en la legitimidad que otorgaba la elocuencia de sus oradores, para transformar los hábitos políticos.

Strategies to generate high-titer, high-potency recombinant AAV3 serotype vectors

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Chen Ling

2016-01-01

Full Text Available Although recombinant adeno-associated virus serotype 3 (AAV3 vectors were largely ignored previously, owing to their poor transduction efficiency in most cells and tissues examined, our initial observation of the selective tropism of AAV3 serotype vectors for human liver cancer cell lines and primary human hepatocytes has led to renewed interest in this serotype. AAV3 vectors and their variants have recently proven to be extremely efficient in targeting human and nonhuman primate hepatocytes in vitro as well as in vivo. In the present studies, we wished to evaluate the relative contributions of the cis-acting inverted terminal repeats (ITRs from AAV3 (ITR3, as well as the trans-acting Rep proteins from AAV3 (Rep3 in the AAV3 vector production and transduction. To this end, we utilized two helper plasmids: pAAVr2c3, which carries rep2 and cap3 genes, and pAAVr3c3, which carries rep3 and cap3 genes. The combined use of AAV3 ITRs, AAV3 Rep proteins, and AAV3 capsids led to the production of recombinant vectors, AAV3-Rep3/ITR3, with up to approximately two to fourfold higher titers than AAV3-Rep2/ITR2 vectors produced using AAV2 ITRs, AAV2 Rep proteins, and AAV3 capsids. We also observed that the transduction efficiency of Rep3/ITR3 AAV3 vectors was approximately fourfold higher than that of Rep2/ITR2 AAV3 vectors in human hepatocellular carcinoma cell lines in vitro. The transduction efficiency of Rep3/ITR3 vectors was increased by ∼10-fold, when AAV3 capsids containing mutations in two surface-exposed residues (serine 663 and threonine 492 were used to generate a S663V+T492V double-mutant AAV3 vector. The Rep3/ITR3 AAV3 vectors also transduced human liver tumors in vivo approximately twofold more efficiently than those generated with Rep2/ITR2. Our data suggest that the transduction efficiency of AAV3 vectors can be significantly improved both using homologous Rep proteins and ITRs as well as by capsid optimization. Thus, the combined use of

Fragilidad financiera en colombia y las decisiones de política monetaria del banco de la república, 1996-2012

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José Mauricio Gil León

2016-03-01

Full Text Available Este artículo evalúa cuál ha sido el papel de las decisiones de política monetaria del Banco de la República dentro de los procesos de inestabilidad financiera acaecidos en Colombia en el período 1996-2012. Según la revisión de hechos, la crisis de 1999 puso en duda el papel estabilizador del banco central, lo cual reflejó una postura contra-cíclica demasiado débil para la recuperación, y la crisis de 2008 encontró un banco más preparado, aunque con respuesta tardía a los procesos emergentes de fragilidad financiera. A través de estimaciones econométricas se evidencia que una política monetaria contractiva puede inducir una crisis financiera cuando la reacción se da en momentos de mayor estrés financiero. This paper evaluates what has been the role of the monetary policy decisions taken by the Central Bank during the financial instability processes that Colombia has gone through during 1996 – 2012. According to the fact analysis, the 1999 crisis questioned the role of the central bank, which defended a counter-cyclic posture that was not strong enough to lead the economic recovery. The 2008 crisis found a stronger stand­ing Central Bank, even though it answered late to the emerging processes regarding financial fragility. With the use of econometric studies it was proven that a contractive monetary policy can accelerate a financial crisis when the measure is implemented in moments when the financial stress is too high.

Civil society and political power in the Dominican Republic Sociedad civil y poder político en República Dominicana

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Jana MORGAN

2011-03-01

Full Text Available In the Latin American context, the Dominican Republic displays high levels of civic engagement and political activism, yet they have not translated into a civil society that is able to exercise considerable influence in reforming the political system or enhancing democracy. Building on this observation, this article explores two questions. The first is if there is tendency toward dual participation in civic and political organizations, which reduces civil society’s ability to pressure political parties and the State. The second refers to the nature of the connections that civil society participants have with the State and with political parties. The analysis demonstrates that an important segment of the population that participates in civic associations also participates in political parties and in clientelist networks.República Dominicana registra un alto nivel de asociacionismo social y activismo político en el contexto latinoamericano. Esto, sin embargo, no se ha traducido en mayor capacidad de la sociedad civil dominicana para reformar el sistema político y mejorar la democracia. Con este planteamiento de fondo, se exploran dos preguntas. La primera es si existe una tendencia a la coparticipación en las organizaciones sociales y políticas que reduce la capacidad de presión de la sociedad civil sobre los partidos y el Estado. La segunda refiere a la naturaleza del vínculo de los participantes en organizaciones de la sociedad civil con el Estado y los partidos. El análisis muestra el involucramiento de un segmento de participantes en actividades cívicas, también en actividades partidarias y en redes clientelares.

Synthèse bibliographique sur le comportement de recherche de l’hôte chez la punaise de lit (Cimex lectularius) et applications dans le cadre de la lutte intégrée

OpenAIRE

Legrand, Pauline; Verheggen, François; Haubruge, Eric; Francis, Frédéric

2016-01-01

Cette étude analyse le comportement de recherche de l’hôte chez la punaise de lit, Cimex lectularius, en portant une attention particulière sur les stimuli émis par l’Homme et impliqués dans ce processus d’orientation. Elle met également en évidence les applications possibles en matière de lutte intégrée. La punaise de lit est un ectoparasite exclusivement hématophage étroitement lié à l’Homme depuis des millénaires. Lors de sa recherche alimentaire, cet insecte utilise des stimuli émis pa...

Effective action for reggeized gluons, classical gluon field of relativistic color charge and color glass condensate approach

Energy Technology Data Exchange (ETDEWEB)

Bondarenko, S.; Prygarin, A. [Ariel University, Physics Department, Ariel (Israel); Lipatov, L. [St. Petersburg Nuclear Physics Institute, Saint Petersburg (Russian Federation); Hamburg University, II Institute of Theoretical Physics, Hamburg (Germany)

2017-08-15

We discuss application of formalism of small-x effective action for reggeized gluons (Gribov, Sov. Phys. JETP 26:414, 1968; Lipatov, Nucl. Phys. B 452:369, 1995; Lipatov, Phys. Rep. 286:131, 1997; Lipatov, Subnucl. Ser. 49:131, 2013; Lipatov, Int. J. Mod. Phys. Conf. Ser. 39:1560082, 2015; Lipatov, Int. J. Mod. Phys. A 31(28/29):1645011, 2016; Lipatov, EPJ Web Conf. 125:01010, 2016; Lipatov, Sov. J. Nucl. Phys. 23:338, 1976; Kuraev et al., Sov. Phys. JETP 45:199, 1977; Kuraev et al., Zh Eksp, Teor. Fiz. 72:377, 1977; Balitsky and Lipatov, Sov. J. Nucl. Phys. 28:822, 1978; Balitsky and Lipatov, Yad. Fiz. 28:1597 1978), for the calculation of classical gluon field of relativistic color charge, similarly to that done in CGC approach of McLerran and Venugopalan, Phys. Rev. D 49:2233 (1994), Jalilian-Marian et al., Phys. Rev. D 55:5414 (1997), Jalilian-Marian et al., Nucl. Phys. B 504:415 (1997), Jalilian-Marian et al., Phys. Rev. D 59:014014 (1998), Jalilian-Marian et al., Phys. Rev. D 59:014015 (1998), Iancu et al., Nucl. Phys. A 692:583 (2001), Iancu et al., Phys. Lett. B 510:133 (2001), Ferreiro et al., Nucl. Phys. A 703:489 (2002). The equations of motion with the reggeon fields are solved in LO and NLO approximations and new solutions are found. The results are compared to the calculations performed in the CGC framework and it is demonstrated that the LO CGC results for the classical field are reproduced in our calculations. Possible applications of the NLO solution in the effective action and CGC frameworks are discussed as well. (orig.)

Irreducible projective representations and their physical applications

Science.gov (United States)

Yang, Jian; Liu, Zheng-Xin

2018-01-01

An eigenfunction method is applied to reduce the regular projective representations (Reps) of finite groups to obtain their irreducible projective Reps. Anti-unitary groups are treated specially, where the decoupled factor systems and modified Schur’s lemma are introduced. We discuss the applications of irreducible Reps in many-body physics. It is shown that in symmetry protected topological phases, geometric defects or symmetry defects may carry projective Rep of the symmetry group; while in symmetry enriched topological phases, intrinsic excitations (such as spinons or visons) may carry projective Rep of the symmetry group. We also discuss the applications of projective Reps in problems related to spectrum degeneracy, such as in search of models without sign problem in quantum Monte Carlo simulations.

"Vi är inte en tummelplats för dårar" : Hur journalister och ansvariga utgivare resonerar kring och förhåller sig till användargenererat material i lokaltidningar

OpenAIRE

Öberg, Therese; Borgström, Johanna

2010-01-01

Sedan 1700-talet har läsarnas medverkan varit en väsentlig del i tidningarnas produktion. Utan deras deltagande har det inte heller blivit någon tidning. En förändring på området skedde när professionaliseringen av publicistrollen blev ett faktum och läsarnas medverkan ifrågasattes. Samhällsförändringar och tekniska utvecklingar har sedan lett fram till det vi har idag: ett samhälle där medieorganisationerna är i allt större behov av att läsarna återigen deltar i olika former. Syftet med stud...

Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines.

Science.gov (United States)

Démoulins, Thomas; Milona, Panagiota; Englezou, Pavlos C; Ebensen, Thomas; Schulze, Kai; Suter, Rolf; Pichon, Chantal; Midoux, Patrick; Guzmán, Carlos A; Ruggli, Nicolas; McCullough, Kenneth C

2016-04-01

Self-amplifying replicon RNA (RepRNA) are large molecules (12-14 kb); their self-replication amplifies mRNA template numbers, affording several rounds of antigen production, effectively increasing vaccine antigen payloads. Their sensitivity to RNase-sensitivity and inefficient uptake by dendritic cells (DCs) - absolute requirements for vaccine design - were tackled by condensing RepRNA into synthetic, nanoparticulate, polyethylenimine (PEI)-polyplex delivery vehicles. Polyplex-delivery formulations for small RNA molecules cannot be transferred to RepRNA due to its greater size and complexity; the N:P charge ratio and impact of RepRNA folding would influence polyplex condensation, post-delivery decompaction and the cytosolic release essential for RepRNA translation. Polyplex-formulations proved successful for delivery of RepRNA encoding influenza virus hemagglutinin and nucleocapsid to DCs. Cytosolic translocation was facilitated, leading to RepRNA translation. This efficacy was confirmed in vivo, inducing both humoral and cellular immune responses. Accordingly, this paper describes the first PEI-polyplexes providing efficient delivery of the complex and large, self-amplifying RepRNA vaccines. The use of self-amplifying replicon RNA (RepRNA) to increase vaccine antigen payloads can potentially be useful in effective vaccine design. Nonetheless, its use is limited by the degradation during the uptake process. Here, the authors attempted to solve this problem by packaging RepRNA using polyethylenimine (PEI)-polyplex delivery vehicles. The efficacy was confirmed in vivo by the appropriate humoral and cellular immune responses. This novel delivery method may prove to be very useful for future vaccine design. Copyright © 2015 Elsevier Inc. All rights reserved.

Amphipathic DNA polymers exhibit antiviral activity against systemic Murine Cytomegalovirus infection

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Juteau Jean-Marc

2009-12-01

Full Text Available Abstract Background Phosphorothioated oligonucleotides (PS-ONs have a sequence-independent, broad spectrum antiviral activity as amphipathic polymers (APs and exhibit potent in vitro antiviral activity against a broad spectrum of herpesviruses: HSV-1, HSV-2, HCMV, VZV, EBV, and HHV-6A/B, and in vivo activity in a murine microbiocide model of genital HSV-2 infection. The activity of these agents against animal cytomegalovirus (CMV infections in vitro and in vivo was therefore investigated. Results In vitro, a 40 mer degenerate AP (REP 9 inhibited both murine CMV (MCMV and guinea pig CMV (GPCMV with an IC50 of 0.045 μM and 0.16 μM, respectively, and a 40 mer poly C AP (REP 9C inhibited MCMV with an IC50 of 0.05 μM. Addition of REP 9 to plaque assays during the first two hours of infection inhibited 78% of plaque formation whereas addition of REP 9 after 10 hours of infection did not significantly reduce the number of plaques, indicating that REP 9 antiviral activity against MCMV occurs at early times after infection. In a murine model of CMV infection, systemic treatment for 5 days significantly reduced virus replication in the spleens and livers of infected mice compared to saline-treated control mice. REP 9 and REP 9C were administered intraperitoneally for 5 consecutive days at 10 mg/kg, starting 2 days prior to MCMV infection. Splenomegaly was observed in infected mice treated with REP 9 but not in control mice or in REP 9 treated, uninfected mice, consistent with mild CpG-like activity. When REP 9C (which lacks CpG motifs was compared to REP 9, it exhibited comparable antiviral activity as REP 9 but was not associated with splenomegaly. This suggests that the direct antiviral activity of APs is the predominant therapeutic mechanism in vivo. Moreover, REP 9C, which is acid stable, was effective when administered orally in combination with known permeation enhancers. Conclusion These studies indicate that APs exhibit potent, well tolerated

POLÍTICAS DE INCENTIVO À INOVAÇÃO TECNOLÓGICA NO BRASIL - A INTERAÇÃO DAS INSTITUIÇÕES CIENTÍFICAS E TECNOLÓGICAS COM EMPRESAS: UM ESTUDO DO INSTITUTO NACIONAL DE TECNOLOGIA (INT E DAS EMPRESAS DO SETOR QUÍMICO

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Telma de Oliveira

2013-09-01

Full Text Available Esse trabalho tem comoobjetivo, analisar as interações de uma Instituição Científica e Tecnológica(ICT, o Instituto Nacional de Tecnologia (INT, com as empresas do setorquímico, importante área de atuação da instituição. Visa também, avaliar oconhecimento dessas empresas, sobre as políticas de incentivo à inovação, equanto elas tem contribuído para a relação ICT - Empresa. Verificou-se quetanto por parte do INT quanto por parte das empresas, que a maior interaçãoocorre na prestação de serviços tecnológicos. Em relação às políticas deincentivo à inovação verificou-se que a Lei de Inovação e a recente criação daEmpresa Brasileira de Pesquisa e Inovação Industrial - Embrapii ainda nãoimpactaram significativamente na realização de projetos conjuntos de P&D.Constatou-se que há por parte das empresas químicas, um maior interesse pelapolítica de incentivos fiscais (Lei do BEM, fato explicado pela busca namelhoria da competitividade das empresas do setor.

Uso y abuso de la normativa constitucional en la república tardía: el "senatus consultum ultimum" y los "imperia extra ordinem"

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María José HIDALGO de la VEGA

2010-02-01

Full Text Available A lo largo del período tardo-republicano, cuando la virulencia de las luchas políticosociales entre optimates y populares, producto de la agudización de las contradicciones internas del Estado romano, creaba una supuesta situación de grave peligro, se recurría al uso y al abuso de medidas de excepción para restablecer el orden interno y salvaguardar la seguridad del Estado. Nos estamos refiriendo al Senatus consultum de república defendendam, normalmente conocido como senatus consultum ultimum. Este «decreto último» fue uno de los más importantes instrumentos que utilizó el Senado para declarar el estado de emergencia y suspender las garantías constitucionales de los ciudadanos. El decreto senatorial, que a veces venía precedido de una declaración contra rem publicam factura videri, tenía la finalidad de enfrentarse con situaciones límites de índole interna, que con los medios normales constitucionales no se podían solucionar. El ordenamiento jurídico romano contemplaba una magistratura extraordinaria, la dictadura, para hacer frente a situaciones de crisis grave en el orden interno o externo, pero esta magistratura dejó de utilizarse a finales del siglo ni a.C. Posiblemente el desuso en el que cayó tal magistratura esté relacionada con un mayor poder que el Senado fue adquiriendo a partir de ese período

Effect Of Smoking On Thyroid Status In Depression

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Jalaj Saxena

1997-08-01

Full Text Available Research Problem: Whal is Ihe impact of smoking cigarettes on thyroid functions in depression patients. Objective: To estimate T3, T4 and TSH in depressed smokers. Study Design:   Hospital   based clinical  study. Setting: Psychiatry out - door patients. Participants: Depression patients with or without history of smoking. Sample Size:     Twenty five  patients  of depression. Study Variables: Smoking, Non - smoking, T3 , T4 , TSH Statistical Analysis: Student t- test. Result: The patients of both the study group and control group had subnormal T3 but in smokers it was significantly lower than in non - smoker patients. T4 was within the normal range in both the groups, but it was significantly higher in smokers. TSH levels were normal in both the groups of patients and there was no significant difference between the two groups. Conclusion: A low T3 state exists in depression with further worsening of the condition in depressed patients who smoke, which might have an impact on therapeutic outcome. Therefore, avoidance of smoking in depression patients is suggested

Construire ses cartes : le développement d’outils statistiques interactifs intégrés à un SIG

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Benoît Ogier

1999-06-01

Full Text Available Les systèmes d’exploitation des micro-ordinateurs proposent aujourd’hui des interfaces conviviales. En outre, certains micro-SIG offrent des possibilités intéressantes de développement par l’intermédiaire de " plug ins ", dans les langages de programmation les plus courants (Pascal, C, Delphi.... C’est sur ces bases que nous avons pu compléter les fonctionnalités d’un micro-SIG (requêtes spatiales, calcul d’itinéraire, gestion de données, cartographie..., par une série de modules statistiques et graphiques.Ces outils mettent à la disposition de l’utilisateur, toutes les informations statistiques et représentations, nécessaires à une analyse complète des données. En effet, les modules sont liés entre eux, ce qui permet d’aborder une étude sous plusieurs angles simultanément, et de comparer les résultats de différentes méthodes. De plus, une mise a jour automatique de la carte s’effectue dès que l’on procède à une mise en classe à l’aide d’un des modules. On est donc en présence d’une complète interactivité SIG-Cartes-Statistiques.Mais on peut aller plus loin et envisager l’expérimentation d’autres outils graphiques, notamment pour l’exploitation des résultats d’analyses factorielles.

Intégration des données de l'atlas des marais atlantiques alimentés en eau de mer dans un système d'information à référence spatiale

OpenAIRE

Loubersac, Lionel; Manaud, Francois; Loarer, Ronan; Kerdreux, Michel; Durand, Christophe

1998-01-01

Ce papier décrit une méthodologie d’intégration des données analogiques d’un Atlas des marais salés atlantiques dans un SIG. On développe les différentes étapes de la méthode après avoir décrit les données originales sources sous forme de cartographie analogique thématique et de textes associés. Ces étapes incluent la digitalisation, les corrections géométriques, la définition d’une typologie et d’attributs, la mise en place de liens entre les graphiques, textes et images, le croisement de co...

Empleo de sueros diagnósticos producidos en la República Popular China para la serotipificación de Pseudomonas aeruginosa

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Sara C Esnard Bolaños

1997-08-01

Full Text Available Se realizó la serotipificación de 355 cepas de Pseudomonas aeruginosa de origen clínico y ambiental, recibidas de centros provinciales de Higiene y Epidemiología de Cuba durante 1988 y 1989. Se utilizó la técnica de aglutinación en lámina con el empleo de juegos de 20 sueros diagnósticos producidos en el Instituto de Productos Biológicos de Chengdu, República Popular China, que permiten reconocer los 17 antígenos somáticos del Esquema Internacional de Tipificación Antigénica para este microorganismo y 3 descritos recientemente. La tipabilidad alcanzada fue del 97 %, lo que evidenció la factibilidad de estos antisueros. Se demostró la ocurrencia predominante del serotipo 011 y la presencia por primera vez en Cuba de los nuevos tipos somáticos 018 (1 %, 019 (5 % y 020 (3 %.The serotyping of 355 strains of Pseudomonas aeruginosa from clinical and environmental order was carried out. The strains were provided by Cuban Provincial Centers of Hygiene and Epidemiology during 1988 and 1989. The technique of agglutination in plaques was used with the utilization of kits from 20 diagnostic sera produced at the Institute of Biological Products from Chengdu, China, which allowed to recognize 17 somatic antigenic typing for this microorganism and 3 recently described. The typing obtained was found to be of 97 % evidencing the feasibility of these antisera. The predominant occurrence of 011 serotype and the presence for the first time in Cuba of new somatic types such as 018 (1 %, 019 (5 %, and 020 (3 % were proved.

Evaluation of the NMC regional ensemble prediction system during the Beijing 2008 Olympic Games

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Li, Xiaoli; Tian, Hua; Deng, Guo

2011-10-01

Based on the B08RDP (Beijing 2008 Olympic Games Mesoscale Ensemble Prediction Research and Development Project) that was launched by the World Weather Research Programme (WWRP) in 2004, a regional ensemble prediction system (REPS) at a 15-km horizontal resolution was developed at the National Meteorological Center (NMC) of the China Meteorological Administration (CMA). Supplementing to the forecasters' subjective affirmation on the promising performance of the REPS during the 2008 Beijing Olympic Games (BOG), this paper focuses on the objective verification of the REPS for precipitation forecasts during the BOG period. By use of a set of advanced probabilistic verification scores, the value of the REPS compared to the quasi-operational global ensemble prediction system (GEPS) is assessed for a 36-day period (21 July-24 August 2008). The evaluation here involves different aspects of the REPS and GEPS, including their general forecast skills, specific attributes (reliability and resolution), and related economic values. The results indicate that the REPS generally performs significantly better for the short-range precipitation forecasts than the GEPS, and for light to heavy rainfall events, the REPS provides more skillful forecasts for accumulated 6- and 24-h precipitation. By further identifying the performance of the REPS through the attribute-focused measures, it is found that the advantages of the REPS over the GEPS come from better reliability (smaller biases and better dispersion) and increased resolution. Also, evaluation of a decision-making score reveals that a much larger group of users benefits from using the REPS forecasts than using the single model (the control run) forecasts, especially for the heavy rainfall events.

Proceso de sensibilización y empoderamiento local frente al uso sostenible del suelo en la microcuenca El Limón, cuencas altas Sabana Yegua, República Dominicana

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Maldané Cuello Espinosa

2011-05-01

Full Text Available Este artículo trata el desarrollo de un proceso de sensibilización y empoderamiento por parte de los productores y productoras agrícolas de la microcuenca El Limón, dentro del complejo de cuencas que alimentan a la presa Sabana Yegua, en República Dominicana. La metodología implementada en el proceso se basa en un enfoque participativo local, que a su vez está basado en el modelo de Acción Ambiental Positiva (AAP, el cual incluye los elementos de habilidades y procedimientos, conceptos, empoderamiento y actitudes. En el escrito se presenta la aplicación de este enfoque y los productos obtenidos del proceso de sensibilización y empoderamiento. Dentro de los resultados se incluye la adopción de prácticas sostenibles del recurso suelo, donde se desarrollan prácticas de conservación, con el fin de reducir la degradación a la que está expuesto el mencionado recurso. El objetivo es que los productores logren interiorizar y experimentar la importancia de proteger el suelo en términos económicos y ambientales.

La cartografía colonial española durante la Segunda República (1931-1936

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Urteaga, Luis

2010-07-01

Full Text Available The Spanish Second Republic set aside a big amount of resources, both human and economic, to survey the colonies. The consecutive republican governments kept a strong continuity on the schemes for colonial cartography, with no significant changes over the plans established in past periods. Cartographic work was focused in Morocco’s territory, and was carry out by a military unit named Comisión Geográfíca de Marruecos y Límites (Morocco’s Geographical Commission. This paper, built on primary sources, examines the institutional framework of Spanish colonial cartography during the republican period, identifies the leading mapmakers, and discusses the main cartographic surveys.

La Segunda República dedicó cuantiosos recursos, económicos y humanos, a la cartografía de las posesiones coloniales. Los sucesivos gobiernos republicanos mantuvieron una fuerte continuidad, organizativa y funcional, en el ámbito de la cartografía colonial, sin que se detecte ningún cambio significativo respecto a los planes trazados en etapas anteriores. La actividad cartográfica continuó centrada en el territorio de Marruecos, y fue protagonizada por una unidad dependiente del Ministerio de la Guerra, la Comisión Geográfica de Marruecos y Límites. En este trabajo, que se apoya en fuentes primarias, se ofrece una descripción del marco institucional de la cartografía colonial durante el período republicano, se identifica a sus artífices, y se da cuenta de los levantamientos cartográficos realizados. [fr] La Deuxième République a consacré nombreux ressources, économiques et humains, à la cartographie des possessions coloniales. Les successifs gouvernements républicains ont tenu une forte continuité, d’organisation et fonctionnelle, dans le domaine de la cartographie coloniale, sans qu’on ne puisse détecter aucun changement significatif en relation aux plans tracés en étapes antérieures. L’activité cartographique a continu

Insécurité urbaine, analyse criminologique et prévention situationnelle intégrée - Urban insecurity, criminological analysis and integrated situational prevention - Insicurezza urbana, analisi criminologica e prevenzione situazionale integrata

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Koudou O.

2009-08-01

Full Text Available L’insécurité en Côte d’Ivoire est stable. Les actions et missions de la police ne suffisent pas pour la réguler. Il est possible de compléter celles-ci par la stratégie de la prévention situationnelle « intégrée ». Celle-ci porte sur huit points complémentaires : 1- Analyse des problèmes criminels ; 2- Intégration de la technologie de sécurité ; 3- Surveillance continue de précision ; 4- Restauration de sites à risques ; 5- Police de proximité anticipatrice ; 6- Actions coordonnées des régulateurs ; 7- Modification de l’attitude des victimes potentielles ; 8- Evaluation et adaptation des actions.Insecurity in Ivory Coast is stable. Acts and assignments of police are not enough to decline it. It is possible to complete these by the strategy of “integrative” situational prevention. These are supported by eight complementary degrees: 1- Analysis of criminals problems; 2- Integration of security technology; 3- Precision in uninterrupted supervision; 4- Restoration of risks situations; 5- Proximity police for anticipation; 6- Regulator co-ordination acts; 7- Modification of potential victims attitudes; 8- Valuation and adaptation acts.L’insicurezza in Costa d’Avorio è stabile. Le azioni e gli interventi della polizia non sono sufficienti a regolarla ed è possibile completarli tramite la strategia della prevenzione situazionale « integrata ». Quest’ultima si basa su otto punti complementari : 1- Analisi dei problemi di criminalità ; 2- Integrazione della tecnologia di sicurezza ; 3- Sorveglianza continua e puntuale ; 4- Ripristino di situazioni a rischio ; 5- Polizia di prossimità preventiva ; 6- Azioni coordinate di regolazione ; 7- Modifiche dei comportamenti delle vittime potenziali ; 8- Valutazione ed adattamento delle azioni intraprese.

Deaf-mute teaching during the Spanish 2nd Republic period. A historical view Las enseñanzas de sordomudos durante la II República Española. Una perspectiva histórica

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Alfredo ALCINA MADUEÑO

2011-07-01

Full Text Available Deaf-mute teaching during the Spanish 2nd Republic period is an issue which has never been studied in depth consideration and some of its aspects have been not even touched by any research. We could say that deaf-mute education is granted with the characteristics found in general education, at least regarding this specific stage, mainly: economic and budget thoughtful following effort by the governments, methodological renovation, modernization of the educative system, spreading of the school-net, teachers’ formation, etcetera. However it is true that we can fin a very strict-stated idiosyncrasy, which sometimes turns out to be even controversial, not only due to the opposition of different political parties in power during different 2-years periods (31/37 and 34/35, but also because of the republican-socialist governments decisions regarding educative policy. The Republican legacy consists actually much more in documentary facts than in actual realisations, and will have much more application within that political regime that follows and annihilates the Republic than within the period of the Republic itself. The consideration of primary sources (both legal and documental is the base that supports the final conclusions that are provided by means of this exposition.Las enseñanzas de sordomudos en el periodo de la II República española es un tema poco estudiado e inédito en determinados aspectos. Se puede decir que participa de las características de la educación general de dicha etapa: esfuerzo económico y presupuestario de los gobiernos, renovación metodológica, modernización del sistema, ampliación de la red escolar, formación del magisterio, etc., si bien presenta una idiosincrasia muy marcada e incluso contradictoria, no solo por la conocida contraposición de los gobiernos de un bienio y otro (31/33 y 34/35, sino también por las decisiones de política educativa que se toman por los mismos gobiernos de la coalici

Novas linhagens de repôlho e couve-flor para o Estado de São Paulo Improved cabbage and cauliflower types for São Paulo

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Leocádio de Souza Camargo

1956-01-01

Full Text Available A experimentação com repôlho (Brassica oleracea L. var. capitata L. e couve-flor (B. oleracea L. var. botrytis cauliflora, Gars, D.C. foi intensificada no Instituto Agronômico a partir de 1941 e, em 1944 iniciaram-se os trabalhos sôbre o seu melhoramento. No presente trabalho são feitas referências sobre florescimento, polinização, genética, problemas da produção de sementes, deficiência de boro, época de semeação para produção de cabeças e de sementes, pragas e moléstias. Experimentaram-se 74 variedades de repôlho e 59 de couve-flor. O maior grupo de variedades produz bem na época fresca do ano, quando as temperaturas médias mensais variam em tôrno de 22,5°C durante o crescimento, e de 16,5°C, na época de formação de cabeças. Para plantio na época quente do ano, com temperaturas médias mensais variando de 20,4 a 22,6°C, durante o crescimento, e de 18 a 22,2°C, na formação de cabeças, prestam-se a variedade de repôlho paulista "Louco" (I.A.C. n.° 758 melhorada no Instituto Agronômico, e a couve-flor "Early Benares", n.° 1383, procedente de Sutton's Seed, Índia, também adaptada às nossas condições climáticas. Em 1944 iniciou-se em Campinas, na E. E. Central, o melhoramento do repolho "Louco" com material procedente de Mogí das Cruzes, São Paulo. Seus defeitos foram eliminados, possuindo-se dêle boas linhagens. Dêsse repôlho foram produzidas, em campos de cooperação da Divisão de Fomento Agrícola, em 1950 e 1951, respectivamente 750 e 722,5 kg de sementes, obtendo-se em média, 26,5 g por planta ou 53 g por m2. Visando à produção de sementes, a melhor época de semeadura é dezembro. As cabeças formam-se em março e abril; após a retirada da cabeça as gemas do caule brotam; desses brotos, dois dos mais fortes devem ficar para a produção de sementes. O florescimento e a colheita das sementes dão-se em épocas favoráveis. As sementes são colhidas desde 160 dias após o corte da cabe

Le travail de recherche documentaire et de production collective en ligne : Propositions pour l’intégration pragmatique, progressive et incrémentale des technologies numériques dans les pratiques enseignantes

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Jean Heutte

2010-01-01

Full Text Available Inspiré du socioconstructivisme et axé sur l’étayage, le travail de recherche documentaire et de production collective en ligne (Dodge, 1995; March, 1998, 2006 offre une multitude de variantes qui permettent d’accompagner les enseignants dans la conception et la mise en œuvre de situations pédagogiques dans lesquelles: - l’intégration des technologies numériques sera pragmatique, progressive et incrémentale; - les apprenants auront plus à apprendre que les enseignants n’auront à enseigner. In fine, ce type d’activité, adaptable à tous les ordres d’enseignement, semble favorable à l’émergence de dispositifs de formation et d’accompagnement des enseignants en adéquation avec leurs compétences et besoins professionnels.

Hygiène des denrées alimentaires d'origine animale - Synthèse II : Vers une assurance qualité intégrée de la chaîne agro-alimentaire.

OpenAIRE

Vindevogel, Henri; Daube, Georges; Hans, J. C.; Denys, J.; Korsak Koulagenko, Nicolas; Ghafir, Y.

1996-01-01

Suite à une première synthèse décrivant les exigences des normes européennes de l’hygiène dans les industries agro-alimentaires, ce second article fait le point sur la mise en application de ces normes et surtout sur le rôle du médecin vétérinaire dans ce domaine. La médecine vétérinaire désire une approche intégrée de l’assurance qualité de toute la filière de la chaîne alimentaire (Longitudinal Integrated Safety Assurance, LISA). Les médecins vétérinaires sont et doivent être à la base de l...

Enhancing outreach for persons with serious mental illness: 12-month results from a cluster randomized trial of an adaptive implementation strategy.

Science.gov (United States)

Kilbourne, Amy M; Almirall, Daniel; Goodrich, David E; Lai, Zongshan; Abraham, Kristen M; Nord, Kristina M; Bowersox, Nicholas W

2014-12-28

Few implementation strategies have been empirically tested for their effectiveness in improving uptake of evidence-based treatments or programs. This study compared the effectiveness of an immediate versus delayed enhanced implementation strategy (Enhanced Replicating Effective Programs (REP)) for providers at Veterans Health Administration (VA) outpatient facilities (sites) on improved uptake of an outreach program (Re-Engage) among sites not initially responding to a standard implementation strategy. One mental health provider from each U.S. VA site (N = 158) was initially given a REP-based package and training program in Re-Engage. The Re-Engage program involved giving each site provider a list of patients with serious mental illness who had not been seen at their facility for at least a year, requesting that providers contact these patients, assessing patient clinical status, and where appropriate, facilitating appointments to VA health services. At month 6, sites considered non-responsive (N = 89, total of 3,075 patients), defined as providers updating documentation for less than implementation interventions: Enhanced REP (provider coaching; N = 40 sites) for 6 months followed by Standard REP for 6 months; versus continued Standard REP (N = 49 sites) for 6 months followed by 6 months of Enhanced REP for sites still not responding. Outcomes included patient-level Re-Engage implementation and utilization. Patients from sites that were randomized to receive Enhanced REP immediately compared to Standard REP were more likely to have a completed contact (adjusted OR = 2.13; 95% CI: 1.09-4.19, P = 0.02). There were no differences in patient-level utilization between Enhanced and Standard REP sites. Enhanced REP was associated with greater Re-Engage program uptake (completed contacts) among sites not responding to a standard implementation strategy. Further research is needed to determine whether national implementation of Facilitation results

Criminalidade, violência e justiça na Vila de Tamanduá: A reconstrução de estatísticas criminais do Império à República

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Ivan Vellasco

Full Text Available Resumo O artigo apresenta os primeiros resultados consolidados do mapeamento da criminalidade e da justiça ao longo do século XIX até os anos 30 do século XX na região da antiga Comarca do Rio das Mortes, Minas Gerais. Com a reconstrução de taxas de criminalidade comparáveis e seu mapeamento num período dilatado pudemos acompanhar as transformações da justiça e das agências de controle e seus impactos na conflitualidade, nos usos da violência e negociação da ordem. Os dados aqui analisados correspondem ao recorte territorial da antiga vila de Tamanduá, mais tarde município de Itapecerica, e seus desmembramentos, contendo 1133 processos judiciais entre os anos de 1829 e 1930. Os resultados demonstram um aumento exponencial dos crimes violentos a partir da última década do século XIX. Ainda que não conclusiva, a hipótese explicativa recai sobre o processo de desestruturação do sistema de justiça com o advento da República.

Nascer de novo na cidade-jardim da República: Belo Horizonte como lugar de cultivo de corpos (1891-1930 Being born in the "Garden City" of the Republic: Belo Horizonte as a place where bodies are cultivated (1891-1930

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Andrea Moreno

2011-12-01

Full Text Available O advento da República envolveu Minas Gerais em uma experiência inédita em seus domínios, na última década dos Oitocentos. Em apenas seis anos, protagonistas diversos participaram de eventos marcantes, em torno da construção de uma nova capital, que redefiniram lugares de sociabilidade e modos de viver. Nascia Belo Horizonte, planejada e construída para ser a capital das Minas Gerais, vitrine da República, com suas praças, ruas e avenidas projetadas a régua e compasso. A pretensão era obrigar seus habitantes, antigos e novos, a "nascer de novo" com ela, como a poesia de Drummond de Andrade sintetiza. É em meio a tantas e tais vicissitudes que procuramos examinar, em diferentes espaços de sociabilidade urbana da nova capital, dispositivos de natureza diversa que encontravam no corpo o seu destino, como lugar de uma educação, de um cultivo, de uma civilização.The advent of the Republic in the last decade of 1800 was to Minas Gerais state a significant experience. In only six years, several protagonists were involved in remarkable events related to the building of the new capital city, which redefined the places for socialization and different lifestyles. The city of Belo Horizonte was born, planned and built to become the capital of Minas Gerais, a model for the Republic, with its squares, streets and avenues accurately projected with 'rulers and compass'. The main purpose was to make its old and new dwellers 'be born again' with Belo Horizonte, as later summed up in Drummond de Andrade's poem. Based on these aspects, our study focused on examining in different places of urban socialization provided by the new capital city different devices that found in people's bodies their destination, as a place for education, cultivation and civilization.

On the Issue of a Narrow Dating of the Manuscript of the Treaties De Cerimoniis Aulae Byzantinae (Leipzig, Univ. Bibl. Rep. I 17

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Marina A. Kurysheva

2017-11-01

Full Text Available The paper offers new arguments for the more exact dating – autumn-winter of 963 – of the manuscript of the treatise De cerimoniis aulae byzantinae (Leipzig, Univ. Bibl. Rep. I 17. At the end of the list of the tombs of the emperors in the Mausoleum of Constantine the Great in the Church of the Holy Apostles, included in this compilation treatise, the scribe missed three empty lines. The last emperor in the list of buried emperors is Constantine VII Porphyrogenitus; there is no sarcophagus of his son Roman II, known from the later lists of tombs. The list ends with a mention of the “small sarcophagus” (τὸ λαρνάκιον; and there is no indication, whether there was someone buried there. Judging by the chronicles of Yahya of Antioch and Leo Deacon, as well as The Brief History by Michael Psellos, since the death of Emperor Roman II there was a constant danger of the liquidation of his children – Basil, Constantine and Anna. Apparently, this small coffin was prepared for them, and the scribe of the codex left a place to finish the final distribution of the last representatives of the imperial house in the mausoleum. However, all the children saved their lives, and three blank lines in the manuscript were never filled. Consequently, the manuscript was already completed after August 16, 963, and it is unlikely that the work on it was completed much later than the autumn-winter of 963.

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Sabrina R.A. Queiroz

2013-01-01

Full Text Available RNA replicon derived from Flavivirus genome is a valuable tool for studying viral replication independent of virion assembly and maturation, besides being a great potencial for heterologous gene expression. In this study we described the construction of subgenomic replicons of yellow fever virus by yeast-based homologous recombination technique. The plasmid containing the yellow fever 17D strain replicon (pBSC-repYFV-17D, previously characterized, was handled to heterologous expression of the green fluorescent protein (repYFV-17D-GFP and firefly luciferase (repYFV-17D-Luc reporter genes. Both replicons were constructed by homologous recombination between the linearized vector pBSC-repYFV-17D and the PCR product containing homologous 25 nucleotides ends incorporated into PCR primers. The genomic organization of these constructs is similar to repYFV-17D, but with insertion of the reporter gene between the remaining 63 N-terminal nucleotides of the capsid protein and 72 C-terminal nucleotides of the E protein. The replicons repYFV-17D-GFP and repYFV-17D-Luc showed efficient replication and expression of the reporter genes. The yeast-based homologous recombination technique used in this study proved to be applicable for manipulation of the yellow fever virus genome in order to construct subgenomic replicons.O replicon de RNA derivado do genoma de Flavivirus é uma ferramenta valiosa para o estudo de replicação viral independente da montagem e da maturação do virion, além de possuir um grande potencial para expressão de genes heterólogos. Neste estudo nós descrevemos a construção de replicons subgenômicos do vírus da febre amarela utilizando a técnica de recombinação homóloga em levedura. O plasmídeo contendo o replicon do vírus febre amarela cepa 17D (pBSC-repYFV-17D, caracterizado anteriormente, foi manipulado para a expressão heteróloga dos genes repórteres green fluorescent protein (repYFV-17D-GFP e firelly luciferase (rep

A sociologia republicana de Montesquieu

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Luís Alves Falcão

2011-07-01

Full Text Available http://dx.doi.org/10.5007/1806-5023.2011v8n1p1 O presente artigo visa expor os fundamentos sociológicos da teoria política de Montesquieu que orientam o regime republicano. Para tal, seguiu-se de perto as principais obras do autor e também um conjunto selecionado de intérpretes. Mostrou-se que a rejeição da tradição contratualista abre caminho para o surgimento de reflexões sociológicas, que conformam a ancoragem não apenas do republicanismo, mas também de outros regimes. Em seguida, abordou-se o fundamento primeiro do republicanismo, a virtude, e sua explicação sociológica através da relação indivíduo/sociedade. Na terceira parte da argumentação, apresentou-se as características centrais do regime republicano. O artigo conclui que, além de existir uma sociologia da república, esta se refere mais aos usos e costumes, fundamento do republicanismo, do que a forma de governo.

Persistence of antibiotic resistance and plasmid-associated genes in soil following application of sewage sludge and abundance on vegetables at harvest.

Science.gov (United States)

Rahube, Teddie O; Marti, Romain; Scott, Andrew; Tien, Yuan-Ching; Murray, Roger; Sabourin, Lyne; Duenk, Peter; Lapen, David R; Topp, Edward

2016-07-01

Sewage sludge recovered from wastewater treatment plants contains antibiotic residues and is rich in antibiotic resistance genes, selected for and enriched in the digestive tracts of human using antibiotics. The use of sewage sludge as a crop fertilizer constitutes a potential route of human exposure to antibiotic resistance genes through consumption of contaminated crops. Several gene targets associated with antibiotic resistance (catA1, catB3, ereA, ereB, erm(B), str(A), str(B), qnrD, sul1, and mphA), mobile genetic elements (int1, mobA, IncW repA, IncP1 groups -α, -β, -δ, -γ, -ε), and bacterial 16S rRNA (rrnS) were quantified by qPCR from soil and vegetable samples obtained from unamended and sludge-amended plots at an experimental field in London, Ontario. The qPCR data reveals an increase in abundance of gene targets in the soil and vegetables samples, indicating that there is potential for additional crop exposure to antibiotic resistance genes carried within sewage sludge following field application. It is therefore advisable to allow an appropriate delay period before harvesting of vegetables for human consumption.

Wounded Warrior Care and Reintegration Requires a Public-Private Partnership

Science.gov (United States)

2013-06-01

Rep.) Tim Walz of Minnesota introduced a bill to Congress (along with cosponsors Rep. Walter B. Jones, North Carolina; Rep. Thomas Rooney, Florida...Campbell, Fort Bragg, Fort Bliss , Fort Hood, and Joint Base Lewis-McChord. The idea behind these clinics on the nation’s largest military installations

Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg+ Chronic Hepatitis B Infection

OpenAIRE

Al-Mahtab, Mamun; Bazinet, Michel; Vaillant, Andrew

2016-01-01

Previous in vivo studies have suggested that nucleic acid polymers (NAPs) may reduce circulating levels of HBsAg in the blood by blocking its release from infected hepatocytes and that this effect may have clinical benefit. NAP treatment, was evaluated in two clinical studies in patients with HBeAg positive chronic HBV infection. The REP 101 study examined REP 2055 monotherapy in 8 patients and the REP 102 study examined REP 2139-Ca, in monotherapy in 12 patients, 9 of which transitioned to s...

Construction of a series of congenic mice with recombinant chromosome 1 regions surrounding the genetic loci for resistance to intracellular parasites (Ity, Lsh, and Bcg), DNA repair responses (Rep-1), and the cytoskeletal protein villin (Vil).

Science.gov (United States)

Mock, B A; Holiday, D L; Cerretti, D P; Darnell, S C; O'Brien, A D; Potter, M

1994-01-01

The interval of mouse chromosome 1 extending from Idh-1 to Pep-3 harbors the natural resistance gene Ity/Lsh/Bcg; it controls the outcome of infection with Salmonella typhimurium, Leishmania donovani, and several Mycobacterium species. This region also contains a DNA repair gene, Rep-1, which determines the rapidity with which double-strand breaks in chromatin are repaired. BALB/cAnPt and DBA/2N mice differ in their phenotypic expression of these genes. To generate appropriate strains of mice for the study of these genes, a series of 10 C.D2 congenic strains recombinant across a 28-centimorgan interval of mouse chromosome 1 extending from Idh-1 to Pep-3 were derived from crosses of the C.D2-Idh-1 Pep-3 congenic strain back to BALB/cAn. Analyses of these recombinant strains will allow the correlation of biological-immunological phenotypes with defined genetic regions.

Educación Mediática e InteRmetodología Relacional aplicada a los MOOC//Media Literacy and relational Inter-methodology implementation on MOOC

Directory of Open Access Journals (Sweden)

Elisa Hergueta-Covacho

2016-07-01

Full Text Available En el contexto actual de innovación tecnológica aparecen nuevas necesidades de aprendizaje y cobran particular relevancia los procesos pedagógicos. Los MOOC se posicionan como una alternativa educacional disruptiva y como puntos de encuentro educomunicativos abiertos a todos, a través de los cuales podemos acceder a esa inteligencia distribuida y accesible en la Red en la que formar redes relacionales externas e internas y tejer una construcción de conocimiento, a partir de nuevas ideas y de la inteligencia colectiva que se produce. Desde una perspectiva teórica, abordamos la acción educomunicativa inherente a los MOOC, partiendo de la necesidad de implementar una inteRmetodología, en la que el Factor Relacional sea determinante, que disponga de estrategias y prácticas para englobar a los discentes en sus diversas dimensiones, con el objetivo de construir conocimiento común en relación y conexión, desde una reflexión encaminada a la acción y participación, para llegar a una praxis holística.

P1 plasmid replication: initiator sequestration is inadequate to explain control by initiator-binding sites.

OpenAIRE

Pal, S K; Chattoraj, D K

1988-01-01

The unit-copy plasmid replicon mini-P1 consists of an origin, a gene for an initiator protein, RepA, and a control locus, incA. Both the origin and the incA locus contain repeat sequences that bind RepA. It has been proposed that the incA repeats control replication by sequestering the rate-limiting RepA initiator protein. Here we show that when the concentration of RepA was increased about fourfold beyond its normal physiological level from an inducible source in trans, the copy number of a ...

Energy metabolism during repeated sets of leg press exercise leading to failure or not

DEFF Research Database (Denmark)

Gorostiaga, Esteban M; Navarro-Amézqueta, Ion; Calbet, José A L

2012-01-01

This investigation examined the influence of the number of repetitions per set on power output and muscle metabolism during leg press exercise. Six trained men (age 34 ± 6 yr) randomly performed either 5 sets of 10 repetitions (10REP), or 10 sets of 5 repetitions (5REP) of bilateral leg press...... exercise, with the same initial load and rest intervals between sets. Muscle biopsies (vastus lateralis) were taken before the first set, and after the first and the final sets. Compared with 5REP, 10REP resulted in a markedly greater decrease (P...

Identification and molecular epidemiology of dermatophyte isolates by repetitive-sequence-PCR-based DNA fingerprinting using the DiversiLab system in Turkey.

Science.gov (United States)

Koc, A Nedret; Atalay, Mustafa A; Inci, Melek; Sariguzel, Fatma M; Sav, Hafize

2017-05-01

Dermatophyte species, isolation and identification in clinical samples are still difficult and take a long time. The identification and molecular epidemiology of dermatophytes commonly isolated in a clinical laboratory in Turkey by repetitive sequence-based PCR (rep-PCR) were assessed by comparing the results with those of reference identification. A total of 44 dermatophytes isolated from various clinical specimens of 20 patients with superficial mycoses in Kayseri and 24 patients in Hatay were studied. The identification of dermatophyte isolates was based on the reference identification and rep-PCR using the DiversiLab System (BioMerieux). The genotyping of dermatophyte isolates from different patients was determined by rep-PCR. In the identification of dermatophyte isolates, agreement between rep-PCR and conventional methods was 87.8 % ( 36 of 41). The dermatophyte strains belonged to four clones (A -D) which were determined by the use of rep-PCR. The dermatophyte strains in Clone B, D showed identical patterns with respect to the region. In conclusion, rep-PCR appears to be useful for evaluation of the identification and clonal relationships between Trichophyton rubrum species complex and Trichophyton mentagrophytes species complex isolates. The similarity and diversity of these isolates may be assessed according to different regions by rep-PCR. © 2017 Blackwell Verlag GmbH.

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

NARCIS (Netherlands)

Maclaren, R.E.; Groppe, M.; Barnard, A.R.; Cottriall, C.L.; Tolmachova, T.; Seymour, L.; Clark, K.; During, M.J.; Cremers, F.P.M.; Black, G.C.M.; Lotery, A.J.; Downes, S.M.; Webster, A.R.; Seabra, M.C.

2014-01-01

BACKGROUND: Choroideremia is an X-linked recessive disease that leads to blindness due to mutations in the CHM gene, which encodes the Rab escort protein 1 (REP1). We assessed the effects of retinal gene therapy with an adeno-associated viral (AAV) vector encoding REP1 (AAV.REP1) in patients with

Integrator complex plays an essential role in adipose differentiation

International Nuclear Information System (INIS)

Otani, Yuichiro; Nakatsu, Yusuke; Sakoda, Hideyuki; Fukushima, Toshiaki; Fujishiro, Midori; Kushiyama, Akifumi; Okubo, Hirofumi; Tsuchiya, Yoshihiro; Ohno, Haruya; Takahashi, Shin-Ichiro; Nishimura, Fusanori; Kamata, Hideaki; Katagiri, Hideki; Asano, Tomoichiro

2013-01-01

Highlights: •IntS6 and IntS11 are subunits of the Integrator complex. •Expression levels of IntS6 and IntS11 were very low in 3T3-L1 fibroblast. •IntS6 and IntS11 were upregulated during adipose differentiation. •Suppression of IntS6 or IntS11 expression inhibited adipose differentiation. -- Abstract: The dynamic process of adipose differentiation involves stepwise expressions of transcription factors and proteins specific to the mature fat cell phenotype. In this study, it was revealed that expression levels of IntS6 and IntS11, subunits of the Integrator complex, were increased in 3T3-L1 cells in the period when the cells reached confluence and differentiated into adipocytes, while being reduced to basal levels after the completion of differentiation. Suppression of IntS6 or IntS11 expression using siRNAs in 3T3-L1 preadipocytes markedly inhibited differentiation into mature adipocytes, based on morphological findings as well as mRNA analysis of adipocyte-specific genes such as Glut4, perilipin and Fabp4. Although Pparγ2 protein expression was suppressed in IntS6 or IntS11-siRNA treated cells, adenoviral forced expression of Pparγ2 failed to restore the capacity for differentiation into mature adipocytes. Taken together, these findings demonstrate that increased expression of Integrator complex subunits is an indispensable event in adipose differentiation. Although further study is necessary to elucidate the underlying mechanism, the processing of U1, U2 small nuclear RNAs may be involved in cell differentiation steps

El Paleolítico Medio en el Cáucaso Meridional: la Cueva Doble (Valle de Tsutskhvati, República de Georgia

Directory of Open Access Journals (Sweden)

Fernando DÍEZ MARTÍN

2010-08-01

Full Text Available El presente trabajo recoge los principales resultados derivados de la intervención arqueológica acometida entre los años 2002 y 2003 en el Valle de Tsutskhvati (República de Georgia, principalmente centrados en una nueva ronda de excavaciones en la Cueva Doble. Los estudios estratigráficos, tecnológicos, tafonómicos y polínicos permiten arrojar nuevos datos, complementarios a los obtenidos en la cercana cueva de Ortvale Klde, sobre las comunidades neandertales que habitaron la región del Cáucaso meridional, uno de los entornos geográficos en los que sobrevivieron los últimos representantes de esta especie. Mientras que los completos trabajos arqueológicos abordados en la cueva de Ortvale Klde han permitido contar con un amplio programa de datación para la presencia neandertal en dicha cavidad, el resto de los yacimientos del mismo periodo siguen presentando una cierta indefinición contextual. A pesar de ello, se acepta que la presencia neandertal en el valle de Tsutskhvati debió situarse en el mismo marco temporal que en Ortvale Klde. Aunque tanto la Cueva Doble, motivo de esta publicación, como la famosa Cueva del Bronce carecen hoy en día de contextos cronológicos fiables, es necesario señalar que estos yacimientos del valle de Tsutskhvati vienen siendo recurrentemente citados en el debate sobre el fin de los neandertales y la llegada de las primeras comunidades sapiens a la región caucásica. Es por ello por lo que la información novedosa aquí presentada (los últimos trabajos en Tsutskhvati se llevaron a cabo en la década de 1970 posee un indudable interés, a pesar de las limitaciones cronológicas, para ampliar nuestro conocimiento sobre este importante capítulo de la Prehistoria europea.

UNA virus: first report of human infection in Argentina Virus UNA: primeiro registro de infecção em humanos na República Argentina

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Luis Adrián Diaz

2003-04-01

Full Text Available Una virus (UNAV, Togaviridae family, is widely distributed in South America, where infections have been detected in mosquitoes and vertebrate hosts (humans, birds and horses. We analyzed human sera from Córdoba inhabitants aged 44 to 89 years and using a neutralization test, we found a prevalence of UNAV antibodies of 3.8% (3/79. The low titers detected suggest past infections probably acquired in rural areas of the Province of Córdoba (central Argentina. None sera were found positive for MAYV neutralizing antibodies. This is the first report of human infections by UNAV in Argentina.O virus Una (Togaviridae tem ampla distribuição na América do Sul, detectando-se infecções até hoje em mosquitos e hospedeiros vertebrados (humanos, aves e cavalos. Mediante a realização do teste de neutralização em soros humanos provenientes de indivíduos entre 44 e 89 anos, da cidade de Córdoba, foi detectada uma prevalência de 3,8% (3/79 de anticorpos para o vírus UNA. Nenhum soro apresentou anticorpos para o vírus Mayaro. Os títulos foram baixos demonstrando-se a presença de infecção passada. Dados epidemiológicos indicam que a infecção ocorreu em áreas rurais da província de Córdoba (centro da Argentina. Os dados aqui expostos representam o primeiro registro de infecção de humanos por vírus Una na República Argentina.

Relatives appositives : entre intégration syntaxique et intégration discursive

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Lytvynova Maryna

2014-07-01

Full Text Available L’objectif du présent travail est de mettre en lumière certaines propriétés discursives des relatives appositives du français et, par la même occasion, de participer au débat sur le statut dont elles jouissent au niveau du discours. Plus spécifiquement, en prenant comme point de départ la discussion antérieure (cf. Brandt, 1990 ; Combettes, 1992 ; Lambrecht, 1998 ; Holler, 2005 ; Loock, 2007 portant sur la distinction fonctionnelle entre les relatives narratives (1 et les relatives descriptives (2, nous suggérons que, contrairement à ce que postulent les travaux précédents, ni les premières, ni les secondes ne peuvent être assimilées à des unités autonomes du discours, l’hypothèse que nous étayons avec des données expérimentales

El anticlericalismo y sus consecuencias en las diócesis gallegas durante el período de la II República (1931-1936

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Hernández Figueiredo, José Ramón

2009-12-01

Full Text Available This article shows the pain and desolation of so many galician cities, towns and villages which suffered the violence of the revolutionary hand,specially during the tragic spring of ´36. Its preparation is posible thanks to the oficial opening to the researchers of the documents of the Vatican Secret Archive corresponding to the papacy of Pío XI, by the Pope Benedict XVI. These files sent by Bishops and general Vicars, depending on the circumstances, present outrages, raids and damages, fires, aggressions and inprisonments. The historical or religious sociological indicators which provide the setting for these antireligious outrages, help to comprehend and interpret the presented information and to understand that there really existed a religious persecution under the regime of the II Republic in Galicia.

En este artículo se recoge el dolor y la desolación de tantas ciudades, villas y aldeas gallegas, que padecieron la violencia de la zarpa revolucionaria, especialmente durante la primavera “trágica” del 36. Su elaboración es posible gracias a la apertura oficial a los investigadores de los documentos del Archivo Secreto Vaticano correspondientes al pontificado de Pío XI, por el Papa Benedicto XVI. Estos informes enviados por obispos, vicarios generales o vicarios capitulares, según las circunstancias, presentan desmanes, asaltos y destrozos, incendios, agresiones y encarcelamientos. Los indicadores históricos o de sociología religiosa que enmarcan estos desmanes antirreligiosos, ayudan a comprender e interpretar los datos expuestos y a entender que realmente existió una persecución religiosa bajo el régimen de la II República en Galicia.

Integrin-binding elastin-like polypeptide as an in situ gelling delivery matrix enhances the therapeutic efficacy of adipose stem cells in healing full-thickness cutaneous wounds.

Science.gov (United States)

Choi, Seong-Kyoon; Park, Jin-Kyu; Kim, Jung-Hee; Lee, Kyeong-Min; Kim, Enjoo; Jeong, Kyu-Shik; Jeon, Won Bae

2016-09-10

One crucial issue in stem cell therapy used for tissue repair is often the lack of selective carriers to deliver stem cells to the site of injury where the native extracellular matrix is pathologically damaged or lost. Therefore, it is necessary to develop a biomaterial that is permissive to stem cells and is suitable to replace injured or missing matrix. The major aim of this study is to investigate the potential of an RGD-containing elastin-like polypeptide (REP) with the structure TGPG[VGRGD(VGVPG)6]20WPC to engraft adipose stem cells (ASC) to full-thickness excisional wounds in mice. We implanted REP into the wound defects via body temperature-induced in situ aggregation. Engrafted REP exhibited a half-life of 2.6days in the wounds and did not elicit any pathological immune responses. REP itself significantly accelerated wound closure and reepithelialization and upregulated the expression of dermal tissue components. A combined administration of REP and ASC formed a hydrogel-like ASC/REP composite, which provided better neovascularization than the use of ASCs alone and increased the viability of transplanted ASC, improving overall wound healing. In vitro and in vivo mechanistic investigations suggested that REP enhances ASC survival at least in part via the Fak/Src adhesion-induced upregulation of Mek/Erk and PI3K/Akt survival pathways. We conclude that REP is a promising therapeutic agent for the improvement of stem cell-based therapy for enhanced tissue regeneration and repair. Copyright © 2016 Elsevier B.V. All rights reserved.

Applying radiological emergency planning experience to hazardous materials emergency planning within the nuclear industry

International Nuclear Information System (INIS)

Foltman, A.; Newsom, D.; Lerner, K.

1988-01-01

The nuclear industry has extensive radiological emergency planning (REP) experience that is directly applicable to hazardous materials emergency planning. Recently, the Feed Materials Production Center near Cincinnati, Ohio, successfully demonstrated such application. The REP experience includes conceptual bases and standards for developing plans that have been tested in hundreds of full-scale exercises. The exercise program itself is also well developed. Systematic consideration of the differences between chemical and radiological hazards shows that relatively minor changes to the REP bases and standards are necessary. Conduct of full-scale, REP-type exercises serves to test the plans, provide training, and engender confidence and credibility

Geminivirus vectors for high-level expression of foreign proteins in plant cells.

Science.gov (United States)

Mor, Tsafrir S; Moon, Yong-Sun; Palmer, Kenneth E; Mason, Hugh S

2003-02-20

Bean yellow dwarf virus (BeYDV) is a monopartite geminivirus that can infect dicotyledonous plants. We have developed a high-level expression system that utilizes elements of the replication machinery of this single-stranded DNA virus. The replication initiator protein (Rep) mediates release and replication of a replicon from a DNA construct ("LSL vector") that contains an expression cassette for a gene of interest flanked by cis-acting elements of the virus. We used tobacco NT1 cells and biolistic delivery of plasmid DNA for evaluation of replication and expression of reporter genes contained within an LSL vector. By codelivery of a GUS reporter-LSL vector and a Rep-supplying vector, we obtained up to 40-fold increase in expression levels compared to delivery of the reporter-LSL vectors alone. High-copy replication of the LSL vector was correlated with enhanced expression of GUS. Rep expression using a whole BeYDV clone, a cauliflower mosaic virus 35S promoter driving either genomic rep or an intron-deleted rep gene, or 35S-rep contained in the LSL vector all achieved efficient replication and enhancement of GUS expression. We anticipate that this system can be adapted for use in transgenic plants or plant cell cultures with appropriately regulated expression of Rep, with the potential to greatly increase yield of recombinant proteins. Copyright 2003 Wiley Periodicals, Inc. Biotechnol Bioeng 81: 430-437, 2003.

Reprocessed uranium recycling: the ideal and the facts

International Nuclear Information System (INIS)

Comte, D.

1998-01-01

Commercial reprocessing of Light Water Reactor (LWR) spent fuel provides Reprocessed Uranium (RepU) and plutonium, both products containing a large amount of energy. As the gap, already quite large, between uranium consumption and production threatens to grow, these materials show today a strong strategic benefit, constituting a substantial and reliable source of supply for nuclear fuel manufacturing. RepU, which represents about 96% of recycled materials, can be used in all major types of nuclear power reactor currently in operation. This paper focuses on RepU recycling in LWRs, the feasibility of which is technically well established world-wide, and industrially demonstrated through experience gained within the COGEMA Group. Contrary to a commonly accepted assumption, which probably derives from natural uranium prices remaining for more than a decade at a low level which cannot be sustained into the future, recycling RepU can also bring strong economic benefits to the utilities. It generates savings on uranium procurement that exceed expenditures associated with storing and processing RepU. Thus, the use of this product is an attractive option. The strategic and economic benefits of recycling RepU will become compelling in the near future. Anticipating these needs, the COGEMA Group has developed capabilities to offer utilities the services covering all steps from reprocessing of spent fuel to fuel fabrication using RepU. (author)

Space-filling Curves

Indian Academy of Sciences (India)

void hilbert(int r, int d, int t, int u, int i, int h, int &x, int &y). { if(i >0). { i- -; hilbert ( d,r, u,e ,i,h,x,y); move(r ,h,x,y); hilbert(r,d,t,u,i,h,x,y); move ( d,h,x,y); hilbert(r,d,e,u,i ...

Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg+ Chronic Hepatitis B Infection.

Directory of Open Access Journals (Sweden)

Mamun Al-Mahtab

Full Text Available Previous in vivo studies have suggested that nucleic acid polymers (NAPs may reduce circulating levels of HBsAg in the blood by blocking its release from infected hepatocytes and that this effect may have clinical benefit. NAP treatment, was evaluated in two clinical studies in patients with HBeAg positive chronic HBV infection. The REP 101 study examined REP 2055 monotherapy in 8 patients and the REP 102 study examined REP 2139-Ca, in monotherapy in 12 patients, 9 of which transitioned to short term combined treatment with pegylated interferon alpha 2a or thymosin alpha 1. In both studies NAP monotherapy was accompanied by 2-7 log reductions of serum HBsAg, 3-9 log reductions in serum HBV DNA and the appearance of serum anti-HBsAg antibodies (10-1712 mIU / ml. Eight of the 9 patients transitioning to combined treatment with immunotherapy (pegylated interferon or thymosin alpha 1 in the REP 102 study experienced HBsAg loss and all 9 patients experienced substantial increases in serum anti-HBsAg antibody titers before withdrawal of therapy. For 52 weeks after removal of REP 2055 therapy, rebound of serum viremia (HBV DNA > 1000 copies / ml, HBsAg > 1IU / ml was not observed in 3 / 8 patients. Suppression of serum virema was further maintained for 290 and 231 weeks in 2 of these patients. After withdrawal of all therapy in the 9 patients that transitioned to combination therapy in the REP 102 study, 8 patients achieved HBV DNA < 116 copies / ml after treatment withdrawal. Viral rebound occurred over a period of 12 to 123 weeks in 7 patients but was still absent in two patients at 135 and 137 weeks of follow-up. Administration tolerability issues observed with REP 2055 were rare with REP 2139-Ca but REP 2139-Ca therapy was accompanied by hair loss, dysphagia and dysgeusia which were considered related to heavy metal exposure endemic at the trial site. These preliminary studies suggest that NAP can elicit important antiviral responses during

Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg+ Chronic Hepatitis B Infection.

Science.gov (United States)

Al-Mahtab, Mamun; Bazinet, Michel; Vaillant, Andrew

2016-01-01

Previous in vivo studies have suggested that nucleic acid polymers (NAPs) may reduce circulating levels of HBsAg in the blood by blocking its release from infected hepatocytes and that this effect may have clinical benefit. NAP treatment, was evaluated in two clinical studies in patients with HBeAg positive chronic HBV infection. The REP 101 study examined REP 2055 monotherapy in 8 patients and the REP 102 study examined REP 2139-Ca, in monotherapy in 12 patients, 9 of which transitioned to short term combined treatment with pegylated interferon alpha 2a or thymosin alpha 1. In both studies NAP monotherapy was accompanied by 2-7 log reductions of serum HBsAg, 3-9 log reductions in serum HBV DNA and the appearance of serum anti-HBsAg antibodies (10-1712 mIU / ml). Eight of the 9 patients transitioning to combined treatment with immunotherapy (pegylated interferon or thymosin alpha 1) in the REP 102 study experienced HBsAg loss and all 9 patients experienced substantial increases in serum anti-HBsAg antibody titers before withdrawal of therapy. For 52 weeks after removal of REP 2055 therapy, rebound of serum viremia (HBV DNA > 1000 copies / ml, HBsAg > 1IU / ml) was not observed in 3 / 8 patients. Suppression of serum virema was further maintained for 290 and 231 weeks in 2 of these patients. After withdrawal of all therapy in the 9 patients that transitioned to combination therapy in the REP 102 study, 8 patients achieved HBV DNA < 116 copies / ml after treatment withdrawal. Viral rebound occurred over a period of 12 to 123 weeks in 7 patients but was still absent in two patients at 135 and 137 weeks of follow-up. Administration tolerability issues observed with REP 2055 were rare with REP 2139-Ca but REP 2139-Ca therapy was accompanied by hair loss, dysphagia and dysgeusia which were considered related to heavy metal exposure endemic at the trial site. These preliminary studies suggest that NAP can elicit important antiviral responses during treatment which may

Optimization of analytical parameters for inferring relationships among Escherichia coli isolates from repetitive-element PCR by maximizing correspondence with multilocus sequence typing data.

Science.gov (United States)

Goldberg, Tony L; Gillespie, Thomas R; Singer, Randall S

2006-09-01

Repetitive-element PCR (rep-PCR) is a method for genotyping bacteria based on the selective amplification of repetitive genetic elements dispersed throughout bacterial chromosomes. The method has great potential for large-scale epidemiological studies because of its speed and simplicity; however, objective guidelines for inferring relationships among bacterial isolates from rep-PCR data are lacking. We used multilocus sequence typing (MLST) as a "gold standard" to optimize the analytical parameters for inferring relationships among Escherichia coli isolates from rep-PCR data. We chose 12 isolates from a large database to represent a wide range of pairwise genetic distances, based on the initial evaluation of their rep-PCR fingerprints. We conducted MLST with these same isolates and systematically varied the analytical parameters to maximize the correspondence between the relationships inferred from rep-PCR and those inferred from MLST. Methods that compared the shapes of densitometric profiles ("curve-based" methods) yielded consistently higher correspondence values between data types than did methods that calculated indices of similarity based on shared and different bands (maximum correspondences of 84.5% and 80.3%, respectively). Curve-based methods were also markedly more robust in accommodating variations in user-specified analytical parameter values than were "band-sharing coefficient" methods, and they enhanced the reproducibility of rep-PCR. Phylogenetic analyses of rep-PCR data yielded trees with high topological correspondence to trees based on MLST and high statistical support for major clades. These results indicate that rep-PCR yields accurate information for inferring relationships among E. coli isolates and that accuracy can be enhanced with the use of analytical methods that consider the shapes of densitometric profiles.

Algo más que dopaje. El deporte de alto rendimiento en la antigua república democrática alemana (1950 - 1976=Something more than doping. High performance sport in the old German Democratic Republic (1950-1976

Directory of Open Access Journals (Sweden)

Arnd Krüger

2013-03-01

Full Text Available El presente artículo analiza el uso de sustancias de doping en el deporte de alto rendimiento, en el contexto de la antigua República Democrática Alemana entre os años 1950 y 1976, con el propósito de servir a los intereses políticos del estado y la estructura organizativa que se estableció para poder mantener en secreto los métodos y sistemas de entrenamiento que se empleaban para la consecución de esos éxitos en la alta competición.------------------------------------------------------------------------------The present article analyzes the use of substances of doping in high performance sport, in the context of the old German Democratic Republic between 1950 and 1976 and in order to serve the political interests of the state and the organizational structure that settled down to be able to keep in secret the training methods and systems used for the attainment of great successes in high competition.

Sexo y Modernidad en la España de la Segunda República. Los discursos de la ciencia

Directory of Open Access Journals (Sweden)

Huertas, Rafael

2013-12-01

Full Text Available The aim of this article is to explore the scientific content of the “sexual reform” movement which took place in Spain during the 1920s and 1930s, culminating during the Second Republic. It covers three essential aspects of this subject: 1 the introduction of the new science of sexology; 2 the interest in sex education for children; and 3 the passing of new marriage legislation (the Divorce Law of 1932. Areas of scientific discourse are identified, associated with a “modernization” of mores and based on secular and progressive assumptions. The conflict between biological or endocrinological approaches and psychoanalytical methods is discussed, with encouragement of a healthy, aware experience of sexuality becoming established as the central argument. Issues such as responsible parenting, birth control, prevention of mental disorders (linked to traumatic sexual experiences, etc. are analysed in the light of medical, psychological and legal sources, in relation to the reform of sexual mores and overcoming the bourgeois moral double standardEste artículo pretende estudiar los contenidos científicos del movimiento de “reforma sexual” que tuvo lugar en España en los años veinte y treinta y que culminó durante la Segunda República. Se abordan, al respecto, tres aspectos fundamentales: 1 la introducción de la nueva ciencia sexológica; 2 el interés por la educación sexual de los niños; y 3 la promulgación de una nueva legislación matrimonial (la ley de divorcio de 1932. Se identifican discursos científicos, asimilados a una “modernización” de las costumbres, siempre desde presupuestos laicos y progresistas. Se apunta la confrontación entre enfoques biologicistas o endocrinológicos y planteamientos psicoanalíticos, estableciéndose como eje argumental el fomento de una vivencia consciente y sana de la sexualidad. Temas como paternidad responsable, control de la natalidad, prevención de los trastornos mentales (ligados a

La “Hija Del Pecado”. La República Post Independentista del Siglo XIX en Textos Escolares Venezolanos / The Daughter of Sin: Post-Independence Nineteenth Century Republic, in Venezuelan Textbooks

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Carmen G. Arteaga Mora

2016-12-01

Full Text Available Se muestran resultados de una investigación sobre representaciones de la república venezolana en textos escolares de primaria, publicados durante el gobierno de Hugo Chávez. Concretamente, en este artículo se aborda la representación discursiva del sistema político republicano decimonónico, formado luego de la Independencia. Metodológicamente, se suscribe la perspectiva de Estudios Críticos de Discurso (ECD, según la cual el lenguaje es una forma de acción social, y a través de éste es posible establecer patrones ideológicos. Se analizó el contenido escrito de la sección de ciencias sociales de una muestra de libros de texto de quinto y sexto grado de primaria, ya que es en estos grados donde se aborda el tema de la república venezolana en el siglo XIX. Los hallazgos del análisis permiten concluir que el devenir ocurrido en el país luego de obtenida la Independencia y culminada la separación de la Gran Colombia (1830, se “dibuja” discursivamente escindido de los eventos de la Guerra de Emancipación, de forma que la precariedad sufrida por la sociedad no puede atribuirse a la conflagración experimentada en las primeras décadas del siglo. El “caudillismo” se representa como un elemento desventajoso de la cultura política nacional para la consolidación de las instituciones políticas y de la democracia. El relato reproduce la estructura del culto cívico bolivariano. The Daughter of Sin: Post-Independence Nineteenth Century Republic, in Venezuelan Textbooks ABSTRACT This paper presents results of a research on representations of the Venezuelan republic in primary school textbooks, published during the government of Hugo Chavez. Specifically, discusses the discursive representation of nineteenth-century republican political system, established after Independence. Methodologically, the paper subscribes the perspective of Critical Discourse Analysis (CDA, according to which the language is a form of social action, and

Alliances, party-switching and pork-barrel politics: the Dominican Republic 2010 legislative elections Aliados, tránsfugas y barrilitos: las elecciones legislativas de 2010 en República Dominicana

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Ana Belén BENITO SÁNCHEZ

2011-03-01

Full Text Available This paper analyzes the explanatory factors of the outcome of the legislative and municipal elections of 2010 in Dominican Republic and the recent transformation experienced by the Dominican party system from a tripartism to a plural bipartism.. The leadership of President Fernández, its image, popularity, and pragmatism, are the key factors in the electoral success of the PLD, favored by endemic factionalism into the PRD and the progressive collapse of the PRSC as well. In this context, the PLD consolidated its electoral dominance thanks to the support of minority parties and will control the Legislative branch for the next six years.Este artículo analiza las claves explicativas de los resultados de las elecciones legislativas y municipales de 2010 en República Dominicana así como de la reciente transformación que ha experimentado el sistema de partidos dominicano, del tripartidismo al bipartidismo plural. El liderazgo del presidente Leonel Fernández, su imagen, popularidad y pragmatismo son la clave del éxito electoral del PLD, favorecido también por el faccionalismo endémico del PRD y la descomposición progresiva del PRSC. En esta contienda, el PLD consolida su dominio electoral gracias al apoyo de los partidos minoritarios y se asegura el control del Legislativo durante los próximos seis años.

Improvement Methods in NPP's Radiation Emergency Plan: An Administrative Approach

International Nuclear Information System (INIS)

Lee, Yoon Wook; Yang, He Sun

2009-01-01

The Radiation Emergency Plan (REP) can be divided into a technical and an administrative responses. The domestic NPP's REPs are reviewed from the viewpoint of the administrative response and improvement methods are also suggested in this treatise. The fields of the reviews are the composition of the emergency response organizations, the activation criteria of the organizations, the selection of the staffings and the reasonableness of the REP's volume. In addition, the limitations of the current radiation exercises are reviewed and the improvement method of the exercise is presented. It is expected that the suggested recommendations will be helpful in establishing useful REPs and making practical radiation exercises in Korea

A percepção de universitários sobre a atuação do intérprete de libras no ensino superior

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Jessica Roberta da Silva Corrêa

2017-08-01

Full Text Available O trabalho tem por objetivo analisar a percepção de estudantes surdos e ouvintes sobre a atuação do intérprete de Libras, no contexto universitário. A sua presença e atuação profissional, nessa etapa de ensino, têm sido consideradas um fato recente que, dentre outros aspectos, busca amenizar os obstáculos de comunicação e aprendizagem encontradas por estudantes surdos em processo de formação universitária. Participaram do estudo nove acadêmicos do curso de Arquivologia, sendo um deles surdo, de uma Universidade Pública, localizada no interior do Estado de São Paulo. Os dados foram coletados por intermédio de entrevistas focais, cujas seções de coleta foram registradas por vídeos gravações e, posteriormente, analisadas a partir da técnica de “associação de ideias”. Os universitários foram capazes de reconhecer a importância da presença desse profissional, na formação acadêmica do graduando surdo, reforçando a necessidade de medidas institucionais que apoiem a oferta, sem restrição, para efetivação da sua contratação no contexto universitário.

Intégration des CLOM dans une université à distance – Retour d’expérimentation à la TÉLUQ

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Gilbert Paquette

2016-01-01

Full Text Available Dans une université à distance comme la Télé-université (TÉLUQ, pratiquant la formation à distance depuis plus de 40 ans et offrant la formation en ligne depuis une vingtaine d’années, l’intégration de cours en ligne ouverts et massifs (CLOM; MOOC en anglais se posait dans un contexte très différent de celui d’une université offrant principalement des cours en présence. Pour clarifier les enjeux, un projet pilote a été réalisé à la TÉLUQ à la fin de 2014 dans lequel deux cours ont été produits et diffusés à l’international en mode CLOM. Les objectifs de ce projet consistaient à évaluer les possibilités offertes par les approches pédagogiques réalisées dans les CLOM par rapport à celles en usage en formation à distances (FAD à la TÉLUQ; à établir un processus d’adaptation des cours en ligne pour une diffusion massive; à élaborer une stratégie de communication et de recrutement international pour ces cours et finalement à définir un modèle de diffusion cible pour les CLOM en prenant en compte les caractéristiques d’une université à distance comme la TÉ- LUQ. Cet article présente un retour d’expérience de ce projet pilote, ainsi qu’une synthèse du modèle de diffusion en mode CLOM qui en a résulté.

Retroperitoneal ectopic pregnancy: a case report and review of the literature.

Science.gov (United States)

Yang, Man; Cidan, Lamu; Zhang, Dan

2017-10-16

Retroperitoneal ectopic pregnancy (REP) is an extremely rare type of ectopic pregnancy, with a total of less than 20 cases reported in the English literature. However, failure to recognize REP may result in severe consequences. We report a case of 32-year-old woman with REP. She had amenorrhea, left lower abdominal pain, but no vaginal bleeding. Her urine human chorionic gonadotropin (HCG) test was positive and blood HCG level was 1880 m-international units per milliliter (mIU/mL). Transvaginal ultrasound sonography showed a left adnexal mass. Laparoscopy found an enlarged uterus, normal right uterine tube and ovary, and normal left uterine tube. The left ovary was partly covered by a blood clot, but appeared normal after removing the clot. There was a 10-mm circular peritoneal defect located lateral to the left sacrocervical ligament, anterior to the left ovarian fossa, and next to the lower edge of the left broad ligament. The patient was diagnosed of having REP with the gestational tissues covered by the peritoneum. The REP was removed by laparoscopic surgery. Bleeding was stopped by bipolar coagulation and absorbable hemostatic cellulose. The patient recovered smoothly and was discharged on the next day after surgery. Her blood HCG returned to normal range 29 days after surgery. REP is very rare, but in any suspected case of ectopic pregnancy, caution must be paid to find signs of REP when the common sites of ectopic pregnancy do not have any positive findings.

Functional characterization of a strong bi-directional constitutive plant promoter isolated from cotton leaf curl Burewala virus.

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Zainul A Khan

Full Text Available Cotton leaf curl Burewala virus (CLCuBuV, belonging to the genus Begomovirus, possesses single-stranded monopartite DNA genome. The bidirectional promoters representing Rep and coat protein (CP genes of CLCuBuV were characterized and their efficacy was assayed. Rep and CP promoters of CLCuBuV and 35S promoter of Cauliflower mosaic virus (CaMV were fused with β-glucuronidase (GUS and green fluorescent protein (GFP reporter genes. GUS activity in individual plant cells driven by Rep, CP and 35S promoters was estimated using real-time PCR and fluorometric GUS assay. Histochemical staining of GUS in transformed tobacco (Nicotiana tabacum cv. Xanthi leaves showed highest expression driven by Rep promoter followed by 35S promoter and CP promoter. The expression level of GUS driven by Rep promoter in transformed tobacco plants was shown to be two to four-fold higher than that of 35S promoter, while the expression by CP promoter was slightly lower. Further, the expression of GFP was monitored in agroinfiltrated leaves of N. benthamiana, N. tabacum and cotton (Gossypium hirsutum plants using confocal laser scanning microscopy. Rep promoter showed strong consistent transient expression in tobacco and cotton leaves as compared to 35S promoter. The strong constitutive CLCuBuV Rep promoter developed in this study could be very useful for high level expression of transgenes in a wide variety of plant cells.

Intérêt nutritionnel des huiles de tournesols : tournesol linoléique et tournesol à haute teneur en oléique

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Delplanque Bernadette

2000-11-01

Full Text Available Depuis les années 60 le tournesol traditionnel représentait le chef de file des « huiles poly-insaturées ». Depuis l’apparition des premières variétés riches en acide oléique (18:1, les sélections naturelles ou traditionnelles de variétés nouvelles de tournesol oléique ont trouvé leur place et leur justification sur le plan nutritionnel, par la qualité diversifiée de leurs acides gras, mais aussi par la préservation des qualités de l’insaponifiable (riche en vitamine E et en phytostérols. Une complémentarité entre les tournesols linoléique et oléique pourrait être tout à fait intéressante par l’utilisation d’huiles combinées, en vue d’un équilibre diététique mono/poly-insaturé dont l’effet serait d’assurer l’expression optimale des paramètres de protection vis-à-vis de l’athérothrombose à l’origine des maladies cardiovasculaires. Le développement du « tournesol-mid-oléique » (mid-range-oleic pourrait également apporter une source d’oléique et de linoléique naturellement plus équilibrée. Cependant, il restera à satisfaire les besoins en alpha-linolénique (importance de la balance n-6/n-3 qui pourraient être apportés par le colza.

Effectiveness of a Releasing Exercise Program on Anxiety and Self-Efficacy Among Nurses.

Science.gov (United States)

Chen, Huei-Mein; Wang, Hsiu-Hung; Chiu, Min-Hui

2016-02-01

The purpose of this study was to evaluate the effectiveness of a releasing exercise program (REP) on anxiety and exercise self-efficacy among nurses. The REP consisted of warm-up and tension-releasing exercises and mood adjustment. Ninety-nine nurses (age = 33.38 ± 7.38 years) experiencing anxiety (average Visual Analog Scale for Anxiety [VASA] score of 5.63 ± 1.44 at baseline) were randomly assigned to an experimental group (n = 50) that received 50-min REP sessions 3 times a week or a control group (n = 49) that did not attend REP sessions. The outcome measures were VASA, the Chinese Version of the Beck Anxiety Inventory, and Exercise Self-Efficacy Scale scores. At Weeks 12 and 24, the experimental group had significantly lower anxiety levels and higher exercise self-efficacy scores than the control group. Therefore, the REP effectively reduces anxiety and enhances self-confidence in exercise capability. © The Author(s) 2014.

[Attitudes of general practitioners to pharmaceutical sales representatives in Sousse].

Science.gov (United States)

Ben Abdelaziz, A; Harrabi, I; Rahmani, S; Ghedira, A; Gaha, K; Ghannem, H

2003-01-01

The therapeutic knowledge of physicians is the corner stone to the rational use of medicines; however information about medicines is generally obtained from the pharmaceutical industry via their sales representatives (reps). We aimed to identify general practitioners' (GPs) attitudes to pharmaceutical reps and the information they provide. We surveyed 140 GPs using a self-administered questionnaire. The response rate was 78% (72 GPs from the public sector and 68 from the private sector). About 10% of the GPs said they received daily visits from pharmaceutical reps; 84% of GPs considered them an efficient source of information and 31% said they might change their therapeutic prescribing following visits from these reps. Because of their positive perception of pharmaceutical reps, GPs are susceptible to the information they provide. Controlling the validity of the therapeutic information imparted by the pharmaceutical industry is thus a fundamental component of the programme for the rational use of medicines.

Comercio y virtud en el pensamiento de Montesquieu

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Daniel Mansuy

2016-01-01

Full Text Available Se examina la relación de Montesquieu con la idea republicana a partir del concepto de república comercial. Si el principio de la república es la virtud, el carácter de esta última es por momentos problemático; pero todo indica que la república comercial busca preparar al lector para acoger la posibilidad comercial encarnada en el modelo inglés.

Study of the Generation of Intense Pulsed Electron Beams Using Glow Discharges

Science.gov (United States)

1988-02-01

de Investigaciones Opticas, Rep. Argentina. (2) On leave from PROFET (UNCPBA) Programa de Fisica Experimental Tandil, Rep. Argentina. (3) Edwards... de Investigaciones Opticas, (CIC-BA) Rep. Argentina. Section III-D. Measurements of the plasma density andB. T. Szapiro is on leave from Programa de ...discussed. The radial profiles Szapiro was supported by a fellowship from the Universidad Nacional de show the presence of a high-current-density

Use of reprocessed uranium. Proceedings of a technical committee meeting held in Vienna, August 2007

International Nuclear Information System (INIS)

2009-11-01

Reprocessed uranium (RepU), the uranium recovered from nuclear processing, is produced by several Member States in their facilities or through commercial contracts. From a sustainable development perspective, recycling of this uranium has become an attractive option for improving the efficiency of natural resource management and reducing radioactive waste accumulation. This publication demonstrates that reprocessing of spent fuel could form a key part of advanced fuel methodologies and describes various reuse options of RepU. In particular, it includes detailed review papers on management, storage, packaging and transport of RepU, reprocessing, utility experience and potential use of RepU. The importance of market aspects, economics and long term perspectives is also addressed

La Migración en la Quinta República: Redimensión del Clivaje Partidista y Nuevos Desarraigos un Fenómeno Reciente de Movilización Social en Venezuela 1999 – 2009

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Luis Eduardo León Ganatios

2014-01-01

Full Text Available El triunfo electoral del Presidente Hugo Chávez trae como consecuencia la reestructuración del clivaje partidista, lo que genera nuevos desarraigos que inducen a que un sector de la población emigre en la búsqueda de nuevas oportunidades laborales y de bienestar económico. Por ende se estudia el impacto de las nuevas políticas dentro de la Quinta República y sus consecuencias en torno al fenómeno migratorio actual que vive Venezuela a partir del año de 1999. Palabras Clave: Migración; Desarraigo, Clivaje partidista; Comportamiento político. Migration in the Fifth Republic: Resizing the Cleavage Partisan and New Uproot a Recent Phenomenon Social Mobilization in Venezuela 1999 - 2009AbstractThe electoral victory of President Hugo Chávez has resulted in the restructuring of partisan cleavage, creating new uprooting inducing a sector of the population migrate in search of new job opportunities and economic prosperity. Thus we study the impact of new policies within the Fifth Republic and its consequences around the current migration in Venezuela from 1999.Keywords: Migration; uprooting; Cleavage partisan political behavior.

Comparison of human and automatic segmentations of kidneys from CT images

International Nuclear Information System (INIS)

Rao, Manjori; Stough, Joshua; Chi, Y.-Y.; Muller, Keith; Tracton, Gregg; Pizer, Stephen M.; Chaney, Edward L.

2005-01-01

Purpose: A controlled observer study was conducted to compare a method for automatic image segmentation with conventional user-guided segmentation of right and left kidneys from planning computerized tomographic (CT) images. Methods and materials: Deformable shape models called m-reps were used to automatically segment right and left kidneys from 12 target CT images, and the results were compared with careful manual segmentations performed by two human experts. M-rep models were trained based on manual segmentations from a collection of images that did not include the targets. Segmentation using m-reps began with interactive initialization to position the kidney model over the target kidney in the image data. Fully automatic segmentation proceeded through two stages at successively smaller spatial scales. At the first stage, a global similarity transformation of the kidney model was computed to position the model closer to the target kidney. The similarity transformation was followed by large-scale deformations based on principal geodesic analysis (PGA). During the second stage, the medial atoms comprising the m-rep model were deformed one by one. This procedure was iterated until no changes were observed. The transformations and deformations at both stages were driven by optimizing an objective function with two terms. One term penalized the currently deformed m-rep by an amount proportional to its deviation from the mean m-rep derived from PGA of the training segmentations. The second term computed a model-to-image match term based on the goodness of match of the trained intensity template for the currently deformed m-rep with the corresponding intensity data in the target image. Human and m-rep segmentations were compared using quantitative metrics provided in a toolset called Valmet. Metrics reported in this article include (1) percent volume overlap; (2) mean surface distance between two segmentations; and (3) maximum surface separation (Hausdorff distance

Évaluer l'impact des stéréotypes dans les supports multimédia Evaluating the impact of stereotypes in multimedia tools

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Joëlle Aden

2006-12-01

Full Text Available La navigation sur Internet offre aux enseignants de langues vivantes un kaléidoscope de supports authentiques variés, qui reflète des points de vues multi perspectivistes sur les réalités socioculturelles des groupes qui utilisent la langue apprise. La navigation est probablement un des usages du multimédia les plus développés dans l'enseignement de masse en langues. Il suffit, pour s'en convaincre, de parcourir les méthodes éditées ces cinq dernières années pour voir que l'outil multimédia est surtout sollicité pour faire des recherches sur des thèmes étudiés en classe et de nombreux travaux ont mis en avant le potentiel de cet outil. Dans les classes, l'idée selon laquelle il est indispensable de laisser les élèves naviguer sans guidage dans l'hypertexte a très vite cédé la place à la nécessité de réduire l'accès aux ressources Internet à l'intérieur de cadres contraints, en général à partir de sites présélectionnés à cet effet en vue de réaliser des tâches dans la langue d'étude. Aujourd'hui, dans la formation en langue des enseignants, deux types de dispositifs Tice (technologies de l'information et de la communication pour l'éducation occupent la première place : les cyberenquêtes (webquests et les échanges par courrier électronique, mais à nouveau, les limites des cyberenquêtes sont perceptibles, elles recréent des contraintes formelles dans lesquelles on force les repérages. Dans cet article, nous nous intéresserons à un dispositif[1] intégrant des activités plus libres de navigation et de choix de supports vidéo que nous avons réintégré dans une démarche culturelle en classe. Nous considérerons la façon dont la variété de ces supports, libres et contraints, influe sur la construction des repères identitaires des élèves. Nous étudierons ce phénomène en lien avec les mécanismes cognitifs et socio discursifs que les apprenants mettent en œuvre lorsqu'ils sont exposés �

La coopération internationale et régional concertant la protection de l'environnement et l'apport du droit nucleaire. L'exemple de la Mer Noir

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Flore POP

2005-10-01

Full Text Available This article presents several short components regarding peaceful uses of nuclear energy, the role played by nuclear energy law, and of complementary institutions and programmes in connection to environmental protection. Additionally, this material discusses not only fundamental principles of cooperation directed towards sustainable development but also general principles of international law, within a framework of institutional intergovernmental and/or non governmental cooperation towards environmental protection, based upon global, regional, national or „No State” context. Dans ce bref article, nous voulons présenter quelques éléments ou repères préliminaires de l’utilisation pacifique de l’énergie nucléaire, le rôle du droit nucléaire, des institutions et programmes adjacents par rapport à la protection de l’environnement, les principes fondamentaux de la coopération pour un développement durable sur le plan régional, ainsi que les principes généraux de droit international susceptibles d’orienter la coopération intergouvernementale ou non-gouvernementale, sur la base des initiatives globales, régionales ou d’intérêt national, ou dans le cadre de la coopération “sans Etat”.

Numériser et mettre en ligne

CERN Document Server

Claerr, Thierry

2010-01-01

Rendre les collections accessibles en ligne est devenu pour les institutions culturelles, d'enseignement et de recherche, un des défis majeurs du début du XXIe siècle. Les projets sont dès à présent nombreux, et concernent tous les types d'établissements et tous les supports. Mener à bien une opération de numérisation et de mise en ligne requiert un ensemble de repères et de connaissances pour l'organisation et la mise en oeuvre d'un projet de numérisation durable. Donner les clés du domaine en se fondant sur des savoirs pratiques et concrets est l'ambition de cet ouvrage, qui fournit un mode opératoire précis pour chacune des grandes étapes à prendre en compte - de la capture à la conservation numérique, en passant par l'interopérabilité, le référencement, et en intégrant l'environnement juridique et réglementaire. Coordonné par Thierry Claerr et Isabelle Westeel, spécialistes du sujet et responsables de formations sur la numérisation et la création de bibliothèques numériques,...

El intérprete: tema y variaciones. Una concepción formativa en construcción desde el proyecto “hacia un modelo alternativo para la educación musical de jóvenes y adultos a nivel superior”

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Ligia Ivette Asprilla

2003-04-01

Full Text Available La complejidad, diversidad y riqueza del campo musical que evade respuestas absolutas invita, al mismo tiempo, a la actividad reflexiva, imaginativa y creadora. Elpresente artículo intenta desarrollar la concepción de educación musical que se gesta desde el proyecto de investigación que actualmente se adelanta en la Facultad de Estudios Musicales de la Universidad Central. Aunque el Proyecto estudia la pedagogía de las áreas teórico-musical e instrumental, este texto, organizado como una composición de Tema y variaciones, como su título lo sugiere, utiliza al intérprete como fuente de inspiración.

Ubiquiter circovirus sequences raise challenges in laboratory diagnosis: the case of honey bee and bee mite, reptiles, and free living amoebae.

Science.gov (United States)

Marton, Szilvia; Ihász, Katalin; Lengyel, György; Farkas, Szilvia L; Dán, Ádám; Paulus, Petra; Bányai, Krisztián; Fehér, Enikő

2015-03-01

Circoviruses of pigs and birds are established pathogens, however, the exact role of other, recently described circoviruses and circovirus-like viruses remains to be elucidated. The aim of this study was the detection of circoviruses in neglected host species, including honey bees, exotic reptiles and free-living amoebae by widely used broad-spectrum polymerase chain reaction (PCR) assays specific for the replication initiation protein coding gene of these viruses. The majority of sequences obtained from honey bees were highly similar to canine and porcine circoviruses, or, were distantly related to dragonfly cycloviruses. Other rep sequences detected in some honey bees, reptiles and amoebae showed similarities to various rep sequences deposited in the GenBank. Back-to-back PCR primers designed for the amplification of whole viral genomes failed to work that suggested the existence of integrated rep-like elements in many samples. Rolling circle amplification and exonuclease treatment confirmed the absence of small circular DNA genomes in the specimens analysed. In case of honey bees Varroa mite DNA contamination might be a source of the identified endogenous rep-like elements. The reptile and amoebae rep-like sequences were nearly identical with each other and with sequences detected in chimpanzee feces raising the possibility that detection of novel or unusual rep-like elements in some host species might originate from the microbial community of the host. Our results indicate that attention is needed when broad-spectrum rep gene specific polymerase chain reaction is chosen for laboratory diagnosis of circovirus infections.

Religious policy and secular education during the Second Republic | La política religiosa y la educación laica en la Segunda República

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Mónica Moreno Seco

2003-12-01

Full Text Available This article proposes a redefinition of certain concepts through the analysis of religious policy during the Second Republic. A number of highly controversial measures may be better understood by taking into account the Mediterranean context, pinpointing the various attitudes and positions, or examining more closely social perceptions regarding decisions made by Republican governments. In essence, a distinction needs to be drawn between secular and anticlerical policy, by studying the provisions adopted in religious affairs by the administrations of the first two-year period of the Second Republic. Most of these decisions are of a secular nature, avoiding simplistic descriptions containing terms such as sectarianism and antireligiousness. In short, this article aims to contribute towards an accurate assessment of the Republican period. | Este artículo propone una redefinición de algunos conceptos a partir del análisis de la política religiosa de la Segunda República. La contextualización del caso español en el entorno mediterráneo, la matización de posturas o el acercamiento a las percepciones sociales ante las decisiones de los gobernantes republicanos pueden ayudar a delimitar con precisión unas medidas rodeadas de gran polémica. Se plantea en esencia una distinción entre política laica y política anticlerical desde el estudio de las disposiciones adoptadas en materia religiosa por los gobernantes del primer bienio republicano. La mayor parte de dichas resoluciones se adscriben al ámbito del laicismo, huyendo de caracterizaciones simplistas que acuden a términos como sectarismo o antirreligiosidad. Con ello se persigue contribuir a un balance ajustado del periodo republicano.

Impactos da implantação de um Sistema de Gestão da Qualidade Baseado em Norma ISO na Cultura de Laboratório no Instituto Nacional de Tecnologia – INT

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Nilço Mauro da Silva Moura

2012-04-01

Full Text Available This article describes the effects of implementation of ISO IEC ABNT NBR ISO/IEC 17025in the culture laboratory of the National Institute of Technology and examines how thisinfluences their deployment management model. As analytical model, we used the BrazilianCultural Action Model formulated by Barros and Prates (1996. The model reflected all itscomplexity in the four defined positions: concentration of power; position of spectator;personalist; avoid conflict. The main focus of the study was the influence of organizationculture in favor or prejudice to the implementation and maintenance of the Standard, as wellas their consequences in the final results; the field research confirmed the importance ofrelations between the manager and senior management and between the manager and his teamin this effort. We used descriptive study with qualitative approach and strategy case study,using interviews and direct observations. The study subjects were professionals responsiblefor laboratories in INT, with more than ten years of experience in managing laboratories andparticipating in the implementation of ISO 17025.

Realidad de la cirugía cardíaca en la República Argentina. Registro CONAREC XVI

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Diego M. Lowenstein Haber

2010-01-01

Full Text Available RESUMENIntroducciónLos dos grandes registros multicéntricos de cirugía cardíaca realizados en la Argentina,CONAREC y ESMUCICA, datan de más de 10 años. Considerando los avances médicosy quirúrgicos de la última década, surgió la necesidad de realizar un nuevo registronacional, prospectivo y multicéntrico para conocer las características, la evolución, lascomplicaciones y los predictores de mortalidad de los pacientes sometidos a cirugía cardíaca.ObjetivosConocer el perfil epidemiológico, la modalidad quirúrgica y la evolución posoperatoria de lospacientes sometidos a cirugía cardíaca en la Argentina.Material y métodosRegistro prospectivo, consecutivo y multicéntrico realizado en 49 centros cardioquirúrgicosde la República Argentina por residentes de cardiología. Se analizaron las características yla evolución de 2.553 pacientes sometidos a cirugía cardíaca entre septiembre de 2007 yoctubre de 2008: 1.465 (57,4% a cirugía coronaria, 359 (14,1% a reemplazo valvular aórtico,169 (6,6% a cirugía valvular mitral, 312 (12,2% a cirugía combinada coronariovalvular y248 (9,7% a otros procedimientos.ResultadosHubo predominio de hombres (74,9%; la edad promedio fue de 63 ± 11 años. La prevalenciade diabetes fue del 24,9%, la de hipertensión del 76,3% y la de insuficiencia cardíaca del17%. La disfunción ventricular moderada a grave prequirúrgica fue del 23,8% y el 19,8% delas cirugías fueron no programadas.En las cirugías coronarias, el 41,9% de ellas se realizaron sin circulación extracorpórea y seempleó puente mamario en el 89%.El 81,7% de las cirugías mitrales se indicaron por insuficiencia y el 62,6% de las aórticas,por estenosis. En estas cirugías se emplearon válvulas mecánicas en el 58% de los casos.La mediana de internación fue de 6 días. Se presentaron complicaciones mayores en el31,7% (del 25% en coronarios al 49,36% en combinados y la mortalidad global fue del 7,7%(del 4,3% en coronarios al 13

Intégration verticale et niveau du risque au sein des compagnies pétrolières internationales. Impact sur la volatilité des bénéfices de 15 compagnies entre 1980 et 1989 Vertical Integration and Risk Level in International Oil Companies

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Perruchet D.

2006-11-01

Full Text Available On regroupe couramment les diverses activités pétrolières en deux ensembles que l'on dit complémentaires : l'amont et l'aval. On emploie alors le terme d'intégration verticale pour exprimer le fait qu'une même compagnie soit présente tant à l'amont qu'à l'aval. L'intégration verticale est étudiée ici sur la période 1980-1989 à travers quinze compagnies pétrolières : six Majors et neuf Indépendants. Les volumes d'activité des deux secteurs considérés présentent des évolutions contrastées selon les compagnies et les années. En effet, la recherche d'une intégration verticale plus complète - c'est-à-dire d'une plus grande présence en amont - peut découler de deux logiques différentes. D'un point de vue industriel, si l'amont constitue souvent le fondement de l'activité des compagnies, il existe de plus des facteurs de sécurité d'approvisionnement, d'économie de transaction et d'économie d'échelle. D'un point de vue économique, dans la mesure où les ventes du secteur amont sont les fournitures du secteur aval, c'est l'antisymétrie des résultats des deux secteurs qui est un atout. Il s'agit donc d'analyser les liens entre l'intégration verticale et la stabilité des bénéfices. Sur la période considérée, et pour l'ensemble des compagnies, le coefficient de corrélation entre les bénéfices amont et les bénéfices aval est négatif. L'étude, compagnie par compagnie, montre que plus les compagnies sont intégrées verticalement et plus leurs résultats sont anticorrélés. De même, l'étude des répercussions sur la volatilité des bénéfices est concluante. On constate que la volatilité du bénéfice global (amont et aval est pour chaque compagnie inférieure à celles des bénéfices sectoriels. Des estimations économétriques confirment ces observations. Les Majors se caractérisent par des volatilités faibles, tandis que d'autres compagnies, à forts risques sectoriels, limitent la volatilité de

Programa de ejercicios físicos terapéuticos y masaje para contribuir al tratamiento no farmacológico de pacientes hipertensos entre 35-65 años de edad en el Centro Nacional Hospitalario DONKA (CNHD en Conakry, República de Guinea

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KANN SOULEYMANE

2009-06-01

Full Text Available La hipertensión arterial (HTA es la más común de las enfermedades cardiovasculares que afectan la salud de los individuos en todas las partes del mundo. La práctica de actividad física profiláctica y terapéutica, es la especialidad de la Educación Física que se ocupa de la organización de dichas actividades   con  objetivos   higiénicos, de prevención y  rehabilitación de diferentes alteraciones funcionales, derivadas de causas patológicas o de otra índole,  entre las  que  se  encuentra  la  HTA.  En  muchas  regiones  no  se aprovechan las posibilidades de bienestar que puede aportar la práctica de actividad física. En el Centro Nacional Hospitalario Donka en Conakry, República de Guinea, no se emplea el ejercicio físico para mejorar la salud de los hipertensos. La investigación tiene como objetivo: Proponer un programa de ejercicios físicos terapéuticos y masaje que contribuya al tratamiento no farmacológico de pacientes hipertensos entre 35-65 años edad, en el Centro Nacional Hospitalario DONKA (CNHD en Conakry, República de Guinea. En el mismo se proponen diferentes tipos de ejercicios concebidos en dos fases, una de integración y otra de mantenimiento. En la investigación se utilizaron métodos teóricos, empíricos y estadísticos. Las fuentes de información revelan que algunos de los pacientes que utilizan tratamiento farmacológico, no poseen un nivel de conocimiento de esta patología, ni de los beneficios que aporta la realización de los ejercicios físicos. El programa posee indicaciones y orientaciones   metodológicas    basadas  en las características de esta enfermedad y acordes con  las  condiciones de los pacientes que serán útiles para aplicarse con calidad.

A Case RepOrt

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presents the use of multiple psychological techniques in the management of stuttering. Although there ... Older children and adults often develop additional secondary. Stuttering is .... frustrated posture always sends signals of parasympathetic ...

‘Repping your Ends’

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Rahbek, Ulla

2013-01-01

This article explores the phenomenon of imagined borders in recent multicultural British fiction. Focussing on Sunjeev Sahota’s Ours Are the Streets (2011), Bernadine Evaristo’s Hello Mum (2010), and Stephen Kelman’s Pigeon English (2011), it suggests that borders figure here in a very different...

Repérages bibliographiques

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Sabrina Mommolin

2015-10-01

Full Text Available Commerce électronique - E-commerce AYDIN, E., SAVRUL, B. K. (2014, "The Relationship between Globalization and E-commerce: Turkish Case", Procedia - Social and Behavioral Sciences, vol. 150, pp. 1267-1276. BASTARD, I., BOURREAU, M., MOREAU, F. (2014, "L’impact du piratage sur l’achat et le téléchargement légal: Une comparaison de quatre filières culturelles", Revue économique, vol. 65, n°3, pp. 573-599. FEIZOLLAHI, S., SHIRMOHAMMADI, A., KAHREH, Z. S., et al. (2014, "Investigation the Effe...

Repérages bibliographiques

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Sabrina Mommolin

2016-05-01

Full Text Available Développement durable – Sustainable development APAK S., ATAY E. (2015, “Global Competitiveness in the EU through Green Innovation Technologies and Knowledge Production”, Procedia - Social and Behavioral Sciences, vol. 181, pp. 207-217. BORSDORF A., BENDER O., BRAUN F., HALLER A. (2015, Web-based instruments for strengthening sustainable regional development in the Alps, Geografski Zbornik / Acta Geographica Slovenica, vol. 55, N° 1, pp. 174-182. SIRSIKAR S.V., KAREMORE P. (2015, Design an...