Burnout Stress Syndrome in Child Protection.

Science.gov (United States)

Verstraete, Patricia A.

1994-01-01

Burnout stress syndrome is a complex concept reflecting a failure in both the individual's defense mechanism and in the work environment. Since child protection agencies cannot afford the costs of staff burnout, time and money spent by the organization to reduce employee stress is an investment in better service delivery. (TJQ)

Stress and burnout syndrome among teachers

Directory of Open Access Journals (Sweden)

Grubačić Jelena B.

2013-01-01

Full Text Available Today we talk about professional stress (occupational stress in many occupations. One of the professions that is of a large social significance, reputation and prestige is the teaching profession. However, until recently, only the positive side of this job and profession was emphasized, while the negative aspects and consequences of mental and physical health of employees were considered as something of no great importance. Regarding teachers' work at schools, there are more and more discussions about stress and burnout syndrome, which is related to the demands of the job and the role that teachers perform, as well as to the consequences that are presented in the form of mental and emotional exhaustion. This paper is based on the data from literature, the author's own research and direct experience in the teaching job, an analysis of the most significant sources of stress and on the characteristics of the burnout syndrome among teachers in our schools. As important sources of stress and burnout syndrome among teachers, we point out the following factors: poor student behaviour, too much work, poor working conditions, unequal workload during the school year, a number of school activities that are performed at home, work shifts, and tact and patience in working with students and their parents. Considering teachers' work at schools, combustion model includes three dimensions - exhaustion, depersonalization, and reduced personal accomplishment experience in job, which occurs primarily as a result of claims relating to the roles that teachers perform, including the effects that present themselves in the form of mental and emotional exhaustion.

The medial tibial stress syndrome score: Item generation for a new ...

African Journals Online (AJOL)

The medial tibial stress syndrome score: Item generation for a new patient reported outcome measure. ... instrument that evaluates injury severity and treatment effects for medial tibial stress syndrome (MTSS) patients. ... from 32 Countries:.

Corporate relocation in venture capital finance

NARCIS (Netherlands)

Cumming, D.; Flemming, G.; Schwienbacher, A.

2009-01-01

This paper introduces an analysis of international relocation decisions of venture capital (VC)-backed companies. Relocations to the United States are motivated by economic conditions as well as an improvement in the laws of the country in which the entrepreneurial firm is based. Relocations to the

Patient safety and nursing: interface with stress and Burnout Syndrome

Directory of Open Access Journals (Sweden)

Cláudia Cristiane Filgueira Martins Rodrigues

Full Text Available ABSTRACT Objective: To analyze studies on stress, Burnout Syndrome, and patient safety in the scope of nursing care in the hospital environment. Method: This was an integrative literature review. Data collection was performed in February 2016 in the following databases: Medical Literature Analysis and Retrieval System Online - PubMed/MEDLINE, Latin American and Caribbean Literature in Health Sciences - LILACS. Results: Ten scientific productions were selected, which listed that factors contributing to stress and Burnout Syndrome of nursing professionals are the work environment as a source of stress, and excessive workload as a source of failures. Conclusion: The analysis found that the stress and Burnout Syndrome experienced by these professionals lead to greater vulnerability and development of unsafe care, and factors such as lack of organizational support can contribute to prevent these failures.

[Parenting Stress in Mothers of Children with Down Syndrome in Preschool Age].

Science.gov (United States)

Sarimski, Klaus

2017-11-01

Parenting Stress in Mothers of Children with Down Syndrome in Preschool Age Research suggests that parenting stress is elevated in parents of children with intellectual disabilities. However, data are inconsistent if this holds true for parents of children with Down syndrome. As part of the Heidelberg Down syndrome study, 52 mothers of children with Down syndrome (mean age: 5 years) completed the German adaptation of the Parenting Stress Index. These results show significantly elevated stress scores in scales measuring demanding and less acceptable behavior of the children (child characteristics). Scores in scales measuring parent characteristics do not differ significantly from the norms. Global stress scores are associated with the degree of behavioral problems (SDQ) and adaptive competence (VABS-II). A regression analysis points to optimism as a dispositional trait of the mother which makes a significant contribution to the prediction of parenting stress scores. The implications for early intervention are discussed.

Historical Development of War Stress Reaction Syndromes

Directory of Open Access Journals (Sweden)

Kamil Nahit Ozmenler

2010-02-01

Full Text Available The battles that have come to this day had spectacular psychologic and psychiatric effects. Battle stres reactions in historical development phase has been mentioned with such different names as nostalgia, shell shock, soldier’s heart, Da Costra Syndrome, old sergeant syndrome, agent orange effect and post traumatic stress disorder (PTSD due to the symptoms coming into prominence. On the othere hand they do tend to show similarities (palpilation, stomach complaints, rhomatizmal aches, neurological and psychiatric symptoms, etc. in the context of symptoms and findigs. During the historical phase, the transition of methods have also infliuenced the prominent clinical characteristics of the war stress syndromes. The symptoms that arose during the gulf War have exhibited neither similarities nor explainable characteristics with previous war stress reactions of the past. Therefore, in the context of diagnostics systems, there is no clarity about where it should be incorporated. The inability to find any satisfactory organic pathology in war stress reactions have been the unchanging characteristic of the illness. In collaboration with the increasing mortality and morbidity that arise in wars it is not only an important factor but the resistance of patients, who had been effected, to amelioration is continuing to be an important concern which preoccupies governments, military authorities and doctors. [TAF Prev Med Bull 2010; 9(1.000: 63-70

Clinical correlates of parenting stress in children with Tourette syndrome and in typically developing children.

Science.gov (United States)

Stewart, Stephanie B; Greene, Deanna J; Lessov-Schlaggar, Christina N; Church, Jessica A; Schlaggar, Bradley L

2015-05-01

To determine the impact of tic severity in children with Tourette syndrome on parenting stress and the impact of comorbid attention-deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) symptomatology on parenting stress in both children with Tourette syndrome and typically developing children. Children with diagnosed Tourette syndrome (n=74) and tic-free typically developing control subjects (n=48) were enrolled in a cross-sectional study. Parenting stress was greater in the group with Tourette syndrome than the typically developing group. Increased levels of parenting stress were related to increased ADHD symptomatology in both children with Tourette syndrome and typically developing children. Symptomatology of OCD was correlated with parenting stress in Tourette syndrome. Parenting stress was independent of tic severity in patients with Tourette syndrome. For parents of children with Tourette syndrome, parenting stress appears to be related to the child's ADHD and OCD comorbidity and not to the severity of the child's tic. Subthreshold ADHD symptomatology also appears to be related to parenting stress in parents of typically developing children. These findings demonstrate that ADHD symptomatology impacts parental stress both in children with and without a chronic tic disorder. Copyright © 2015 Elsevier Inc. All rights reserved.

[Emigration in hard conditions: the Immigrant Syndrome with chronic and multiple stress (Ulysses' Syndrome)].

Science.gov (United States)

Achotegui, Joseba

2005-01-01

During the latest years, immigrant populations have been living in very hard conditions. To million people, migration is becoming a process with a high level of stress surpassing the human being capacity of adaptation. This people are prone to suffer the Immigrant Syndrome with chronic and multiple stress and the so called Ulysses Syndrome, what is becoming a serious health problem in the countries that receive the immigrants. This situation is the by-product of the unjust globalization and of the worsening of the living and health conditions of those undergoing such a displacement. In this article, the author postulates a relationship between the high level of stress suffered by the immigrants and their presentation of psychopathological symptoms.

Medial tibial stress syndrome.

Science.gov (United States)

Reshef, Noam; Guelich, David R

2012-04-01

MTSS is a benign, though painful, condition, and a common problem in the running athlete. It is prevalent among military personnel, runners, and dancers, showing an incidence of 4% to 35%. Common names for this problem include shin splints, soleus syndrome, tibial stress syndrome, and periostitis. The exact cause of this condition is unknown. Previous theories included an inflammatory response of the periosteum or periosteal traction reaction. More recent evidence suggests a painful stress reaction of bone. The most proven risk factors are hyperpronation of the foot, female sex, and history of previous MTSS. Patient evaluation is based on meticulous history taking and physical examination. Even though the diagnosis remains clinical, imaging studies, such as plain radiographs and bone scans are usually sufficient, although MRI is useful in borderline cases to rule out more significant pathology. Conservative treatment is almost always successful and includes several options; though none has proven more superior to rest. Prevention programs do not seem to influence the rate of MTSS, though shock-absorbing insoles have reduced MTSS rates in military personnel, and ESWT has shortened the duration of symptoms. Surgery is rarely indicated but has shown some promising results in patients who have not responded to all conservative options.

Stadium Relocation in Professional Football

DEFF Research Database (Denmark)

Junghagen, Sven; Lillo, Gonzalo Leal

The aim of this paper is to conceptually illustrate the tension between commercialisation and club authenticity, which is a potential consequence of stadium relocation. There is a commercial pressure for relocating a football club to new and more modern facilities, but also a pressure from...

75 FR 14442 - Federal Travel Regulation (FTR); Relocation Allowances-Relocation Income Tax Allowance (RITA) Tables

Science.gov (United States)

2010-03-25

... GENERAL SERVICES ADMINISTRATION [GSA Bulletin FTR 10-04] Federal Travel Regulation (FTR); Relocation Allowances-- Relocation Income Tax Allowance (RITA) Tables AGENCY: Office of Governmentwide Policy... (73 FR 35952) specifying that GSA would no longer publish the RITA tables found in 41 CFR Part 301-17...

Relocation and Seismogenic Structure of the 1998 Zhangbei-Shangyi Earthquake Sequence

Science.gov (United States)

Yang, Z.

2002-05-01

An earthquake of magnitude 6.2 occurred in the Zhangbei-Shangyi region in the northern China on January 10, 1998. The earthquake was about 180km to the northwest of the Beijing City and was felt at Beijing. This earthquake is the largest event since the 1976 great Tangshan earthquake of magnitude 7.8 in the northern China. Historically seismicity in the Zhangbei-Shangyi region was very low. In the epicentral area no active fault constituting the seismogenic geological features capable of generating moderate earthquakes like this earthquake has been found before the earthquake. Nor surface faulting has been observed after the earthquake. Field geological investigation after the earthquake found two conjugate surface features trending NNE-NE and NNW-WNW. Because of the geometry of the seismic network the hypocentral distribution of the Zhangbei-Shangyi earthquake sequence given by routine location exhibited no any preferable orientation feature. In this study the Zhangbei-Shangyi earthquake and its aftershocks with magnitude equal or lager than 3.0 were relocated using both the master event relative relocation algorithm and the double-difference earthquake relocation algorithm (Waldhauser, 2000). Both algorithms gave consistent results within accuracy limits. The epicenter of the main shock was 41.15­aN and 114.46­aE, which was located 4km apart from the macro-epicenter of this event. The focal depth of the main shock was 15 km. The epicenters of aftershocks of this earthquake sequence distribute in a nearly vertical plane and its vicinity with orientation N20­aE. The results of relocation for the Zhangbei-Shangyi earthquake sequence clearly indicate that the seismogenic structure of this event is a N20­aE striking fault with right-lateral reverse slip, and that the occurrence of the Zhangbei-Shangyi earthquake is tectonically driven by the horizontal and oriented ENE compression stress, same as that of the stress field in northern China.

Stress reactivity and emotion in premenstrual syndrome

Directory of Open Access Journals (Sweden)

Liu Q

2017-06-01

Full Text Available Qing Liu,1 Yongshun Wang,2 Cornelis Hermanus van Heck,3 Wei Qiao4 1Department of Nuclear Medicine and Medical PET Center, The Second Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 2School of Physical Education and Sport, Huaqiao University, Xiamen, People’s Republic of China; 3DCC, Donders Institute for Neuroscience and Neurocognition, Arnhem, the Netherlands; 4Department of Physical Education, Xiamen Institute of Technology, Xiamen, People’s Republic of China Background: Hormone level fluctuation across the menstrual cycle causes women to experience negative emotions and also affects their mood regulation and stress sensitivity. However, the stress reactivity and emotional variations in women with premenstrual syndrome (PMS, who are especially sensitive to the variations in hormone cycles, have not been explained. Methods: The present study used an electroencephalogram (EEG stress evaluation test, a physiology stress evaluation test, and the positive affect and negative affect scale (PANAS to evaluate the stress reactivity pattern and emotional state of women with PMS. Results: The results showed that women with PMS had higher negative affect and lower positive affect compared with controls. Moreover, under stressful conditions, the women with PMS had a higher alpha activity and a lower respiration rate than the controls. The differences in stress reactivity and emotional states between women with PMS and controls were based on a covariant analysis with menstrual cycle (luteal and follicular phases as the covariate. Conclusion: The results demonstrated that, compared with controls, women suffering from PMS have a continuous abnormality in emotional state and stress reactivity, which was independent of the menstrual cycle. Keywords: premenstrual syndrome, stress reactivity, emotion, EEG stress evaluation test, physiology stress evaluation test

Seizures and pain uncertainty associated with parenting stress and Rett syndrome.

Science.gov (United States)

Byiers, Breanne J; Tervo, Raymond C; Feyma, Timothy J; Symons, Frank J

2014-04-01

Data were collected parenting stress, adaptive behavior, pain, and health issues from the caregivers of 35 girls and women with Rett syndrome (mean age = 20.3). A majority (60%) of parents reported stress in the clinical range on at least 1 subscale of the Parenting Stress Index-Short Form. Seizures and uncertainty about their daughter's gastrointestinal pain experience were significantly associated with higher levels of parenting stress. No other child factors (adaptive behavior, age, residential status) were significantly related to parenting stress. Factors related to chronic health concerns (seizures, ambiguous pain presentation) may be important when considering family stress issues in relation to general outcomes for girls with Rett syndrome and related developmental disorders.

Chronic shin splints. Classification and management of medial tibial stress syndrome.

Science.gov (United States)

Detmer, D E

1986-01-01

A clinical classification and treatment programme has been developed for chronic medial tibial stress syndrome. Medial tibial stress syndrome has been reported to be either tibial stress fracture or microfracture, tibial periostitis, or distal deep posterior chronic compartment syndrome. Three chronic types exist and may coexist: Type I (tibial microfracture, bone stress reaction or cortical fracture); type II (periostalgia from chronic avulsion of the periosteum at the periosteal-fascial junction); and type III (chronic compartment syndrome syndrome). Type I disease is treated nonoperatively. Operations for resistant types II and III medial tibial stress syndrome were performed in 41 patients. Bilaterality was common (type II, 50% type III, 88%). Seven had coexistent type II/III; one had type I/II. Preoperative symptoms averaged 24 months in type II, 6 months in type III, and 33 months in types II/III. Mean age was 22 years (15 to 51). Resting compartment pressures were normal in type II (mean 12 mm Hg) and elevated in type III and type II/III (mean 23 mm Hg). Type II and type II/III patients received fasciotomy plus periosteal cauterisation. Type III patients had fasciotomy only. All procedures were performed on an outpatient basis using local anaesthesia. Follow up was complete and averaged 6 months (2 to 14 months). Improved performance was as follows: type II, 93%, type III, 100%; type II/III, 86%. Complete cures were as follows: type II, 78%; type III, 75%; and type II/III, 57%. This experience suggests that with precise diagnosis and treatment involving minimal risk and cost the athlete has a reasonable chance of return to full activity.

76 FR 41555 - Tupelo, Mississippi Railroad Relocation Project

Science.gov (United States)

2011-07-14

... Relocation Project AGENCY: Federal Railroad Administration (FRA), U.S. Department of Transportation (DOT... Tupelo, Mississippi Railroad Relocation Project (Project). SUMMARY: The Federal Railroad Administration announces the availability of the Tupelo, Mississippi Railroad Relocation Project Draft Environmental Impact...

41 CFR 302-2.5 - May I relocate from a location other than the location specified in my relocation travel...

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false May I relocate from a... Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES INTRODUCTION 2-EMPLOYEES ELIGIBILITY REQUIREMENTS General Rules § 302-2.5 May I relocate from a location other...

Psychological stress-induced cerebrovascular dysfunction: the role of metabolic syndrome and exercise.

Science.gov (United States)

Brooks, Steven; Brnayan, Kayla W; DeVallance, Evan; Skinner, Roy; Lemaster, Kent; Sheets, J Whitney; Pitzer, Christopher R; Asano, Shinichi; Bryner, Randall W; Olfert, I Mark; Frisbee, Jefferson C; Chantler, Paul D

2018-05-01

What is the central question of this study? How does chronic stress impact cerebrovascular function and does metabolic syndrome accelerate the cerebrovascular adaptations to stress? What role does exercise training have in preventing cerebrovascular changes to stress and metabolic syndrome? What is the main finding and its importance? Stressful conditions lead to pathological adaptations of the cerebrovasculature via an oxidative nitric oxide pathway, and the presence of metabolic syndrome produces a greater susceptibility to stress-induced cerebrovascular dysfunction. The results also provide insight into the mechanisms that may contribute to the influence of stress and the role of exercise in preventing the negative actions of stress on cerebrovascular function and structure. Chronic unresolvable stress leads to the development of depression and cardiovascular disease. There is a high prevalence of depression with the metabolic syndrome (MetS), but to what extent the MetS concurrent with psychological stress affects cerebrovascular function is unknown. We investigated the differential effect of MetS on cerebrovascular structure/function in rats (16-17 weeks old) following 8 weeks of unpredictable chronic mild stress (UCMS) and whether exercise training could limit any cerebrovascular dysfunction. In healthy lean Zucker rats (LZR), UCMS decreased (28%, P stress and increased production of nitric oxide in the cerebral vessels. In conclusion, UCMS significantly impaired MCA structure and function, but the effects of UCMS were more substantial in OZR vs. LZR. Importantly, aerobic exercise when combined with UCMS prevented the MCA dysfunction through subtle shifts in nitric oxide and oxidative stress in the cerebral microvasculature. © 2018 The Authors. Experimental Physiology © 2018 The Physiological Society.

Emotional stress and heart rate variability measures associated with cardiovascular risk in relocated Katrina survivors.

Science.gov (United States)

Tucker, Phebe; Pfefferbaum, Betty; Jeon-Slaughter, Haekyung; Khan, Qaiser; Garton, Theresa

2012-01-01

To explore the effects of hurricane exposure and forced relocation on the mind and body, we compared psychiatric diagnoses and symptoms with heart rate variability (HRV) for 34 relocated Katrina survivors and 34 demographically matched controls. All participants were healthy and free of psychiatric and cardiovascular medications. We measured symptoms of posttraumatic stress disorder (PTSD) (Clinician-Administered PTSD Scale 1) and depression (Beck Depression Inventory), Axis I psychiatric diagnoses (Structured Clinical Interview for DSM-IV), psychosocial disability (Sheehan Disability Scale), and power spectral analysis HRV reactivity to trauma reminders. Katrina-related PTSD occurred in 38% of survivors and 12% of controls. Survivors reported higher levels of PTSD and depression symptoms, within diagnostic ranges, and greater psychosocial disability than controls. Survivors had higher resting heart rate (80.82 [standard deviation = 13.60] versus 74.85 [10.67], p = .05), lower parasympathetic (high-frequency [HF] normalized unit) baseline HRV activity (40.14 [23.81] versus 50.67 [19.93], p = .04) and less reactivity with trauma cues (-2.63 [20.70] versus -11.96 [15.84], p = .04), and higher baseline sympathovagal activity (low frequency/HF ratio) (2.84 [3.08] versus 1.35 [1.08], p = .04) than controls. Survivors with depression (n = 12) and with depression and PTSD combined (n = 7), but not those with PTSD (n = 13), had flattened parasympathetic responsiveness to trauma cues. HRV indices correlated with depressive (low frequency/HF, p = .01; HF normalized unit, p = .046) but not PTSD symptoms (p values > .05). Results showed this multilayer trauma's impact on emotional health and HRV-based measures of autonomic nervous system dysregulation. Specifically, dysregulation of depressed survivors' HRV in response to trauma reminders supports more autonomic involvement in traumatic loss/depression than in PTSD. Diagnostic criteria for PTSD include physiologic reactivity

FUMAC-a new model for light water reactor fuel relocation and pellet-cladding interaction

International Nuclear Information System (INIS)

Walton, L.A.; Matheson, J.E.

1984-01-01

An improved approach to the mechanical modeling of fuel rod performance is presented. Previous computer modeling has centered around a unified finite element approach with both fuel pellets and cladding being represented by ring elements. The fuel mechanical analysis code (FUMAC) departs from these approaches in two areas. The pellet model is an empirically based deterministic algorithm, while the cladding model uses both plane stress and plane strain finite elements. The work describes a semiempirical fuel cracking and fragment relocation model, which is burnup and power-level dependent. The interaction of the pellet with the cladding is treated classically. The resulting thick cylinder stresses are used in conjunction with an orthotropic creep model to predict cladding ridging. The resulting ridging compares well with experimental data for both steady-state and transient operating conditions. Future work planned includes the integration of the finite element cladding model with the pellet model and refinement of the pellet relocation and thermal models. Transient performance predictions will be emphasized

[BURNOUT SYNDROME AND STRESS OF NURSING STAFF IN A OURENSE HOSPITAL].

Science.gov (United States)

Soto-Rodríguez, Anxela; Pérez-Fernandez, Ma Reyes

2015-02-01

Set up the stress prevalence and burnout syndrome in different units of nursing staff of the Complexo Hospitalario Universitario de Ourense (CHUOU) and analyse which factors cause it. It has been designed a transversal, descriptive study by performing three assessment instruments: questionnaire of social-demographic variables; Maslach Burnout Inventory (MBI), and Nursing Stress Scale (NSS), to a 117 nursing staff of CHUOU as population. The average age was 39.23 years old and 83.8% were women. The average scoring in the emotional exhaustion dimension was 24.44, in the component of depersonalization was 7.58, and in the personal accomplishment was 34.50. Moreover, 89.7% suffer stress related with work environment. The average score in the dimension of emotional exhaustion was 24.44, the depersonalization of 7.58 and the personal accomplishment of 34.50. The 89.7% suffered from work-related stress. Nursing staff present high burnout syndrome and stress. It has been observed a higher vulnerability to the syndrome from subjects with temporary contract and rotary shift. There has been statistically significant differences in young nursing staff and less career seniority, whom present hiqher stress levels.

Myocordial perfusion SPECT with dipyridamole stress test in cardiac syndrome X

International Nuclear Information System (INIS)

Czepczynski, R.; Smolarek, I.; Sowinski, J.; Rogacka, D.; Kazmierczak, M.; Wysocki, H.

2006-01-01

Cardiac syndrome X defines patients with typical anginal chest pain, a positive exercise ECG stress test and angiographically normal coronary arteries. Aim of this study was to evaluate the role of myocardial perfusion SPECT with dipyridamole stress in the diagnosis of cardiac syndrome X. Patients, methods: 68 patients with syndrome X aged 32 to 60 years were subjected to myocardial imaging using 99m Tc-MIBI according to the two-days protocol: at rest and after dipyridamole infusion. Semiquantitative evaluation of the images was based on the assessment of 99m Tc-MIBI uptake in 17 myocardial segments using a 5-points scale (0 point - normal uptake, 4 points - no uptake). Scores obtained in each segment were summed up, constituting the summed rest score (SRS) and summed stress score (SSS). Results: mean SRS was 7.9 ± 4.8 and mean SSS was 7.2 ± 4.4 (non-significant difference). Individual comparison of SRS and SSS values revealed three patterns of scintigraphic images: (1) in 25 patients (36.8%), a paradoxical improvement of perfusion at stress images was found, (2) in 23 patients (33.8%), the myocardial perfusion deteriorated after dipyridamole, (3) in 20 patients (29.4%), no significant change of the myocordial perfusion between rest and stress images occurred. Conclusions: in cardiac syndrome X, myocardial SPECT with dipyridamole stress shows different patterns of myocardial perfusion that reflects heterogeneity of this pathology. (orig.)

Planner and nuclear crisis relocation

International Nuclear Information System (INIS)

Platt, R.H.

1984-01-01

Criticism of the Federal Emergency Management Agency (FEMA) plans to relocate two-thirds of the American people one week before a nuclear attack has been so intense that planners have renamed the crisis relocation plan to Integrated Emergency Management. A careful study of plans for the town of Greenfield, Massachusetts show that they are not only unworkable, but would seriously weaken the country even if no attack occurred. Recent warnings of a global climatic catastrophe and nuclear winter in the wake of a nuclear exchange underscore the need to denounce relocation policies as dangerous. Planners should take the lead in emphasizing the long-term consequences and informing the public that there is no civil defense against nuclear war. 7 references

The Benefits of Continuous Leisure Participation in Relocation Adjustment Among Residents of Long-Term Care Facilities.

Science.gov (United States)

Lin, Li-Jung; Yen, Hsin-Yen

2018-03-19

The rising population of older adults is transforming Taiwan society. Although many long-term care facilities now operate for older adults, the transition from the home environment to long-term facilities may cause multiple issues, including relocation stress syndrome, for new residents. Autonomy is a critical element of the human experience. Leisure, as an expression of autonomy, has been shown to enhance self-image and promote feelings of competence and mastery. The aim of this study was to assess the relationship between participation in leisure activities and adjustment to residential care using the continuity theory. One hundred sixty-three qualified individuals from 11 long-term care institutions were recruited and completed the questionnaire. The sampling criteria for the study were age (55+ years), appropriate cognitive skills, and residency (less than 5 years). Interviews conducted by trained interviewers were used to collect data. Measured outcomes included leisure participation; physical, psychological, and social adjustments; and background information. Cluster analysis, descriptive analysis, multivariate analysis of variance, and least significant difference test were used in analysis. Type of admission (voluntary/mandated) and type of leisure participation significantly affected the level of relocation adjustment success. Four leisure behavior categories were identified, including reduced participation, expanded participation, active participation, and continuing participation. The participants in the active and continuing participation categories had significantly higher psychological adjustment than their peers in the reduced participation category. Moreover, the continuing participation category had a significantly better level of social adjustment than their expanded participation category peers. Continuous and active participation categories had a beneficial outcome in relocation adjustment. The findings support that, in general, residents of

Oxidative stress, thyroid dysfunction & Down syndrome

Directory of Open Access Journals (Sweden)

Carlos Campos

2015-01-01

Full Text Available Down syndrome (DS is one of the most common chromosomal disorders, occurring in one out of 700-1000 live births, and the most common cause of mental retardation. Thyroid dysfunction is the most typical endocrine abnormality in patients with DS. It is well known that thyroid dysfunction is highly prevalent in children and adults with DS and that both hypothyroidism and hyperthyroidism are more common in patients with DS than in the general population. Increasing evidence has shown that DS individuals are under unusual increased oxidative stress, which may be involved in the higher prevalence and severity of a number of pathologies associated with the syndrome, as well as the accelerated ageing observed in these individuals. The gene for Cu/Zn superoxide dismutase (SOD1 is coded on chromosome 21 and it is overexpressed (~50% resulting in an increase of reactive oxygen species (ROS due to overproduction of hydrogen peroxide (H 2 O 2 . ROS leads to oxidative damage of DNA, proteins and lipids, therefore, oxidative stress may play an important role in the pathogenesis of DS.

Genetic syndromes in the family : child characteristics and parenting stress in Angelman, CHARGE, Cornelia de Lange, Prader-Willi, and Rett syndrome

NARCIS (Netherlands)

Wulffaert, Josette

2010-01-01

Aim of the dissertation: To expand the knowledge on the behavioural phenotypes, level of parenting stress and the relationship between child characteristics and parenting stress in five genetic syndromes. The included syndromes are Angelman, CHARGE, Cornelia de Lange, Prader-Willi, and Rett

Industrial relocation and energy consumption: Evidence from China

International Nuclear Information System (INIS)

Zhao Xiaoli; Yin Haitao

2011-01-01

With economic development and the change of industrial structure, industrial relocation is an inevitable trend. In the process of industrial relocation, environmental externality and social cost could occur due to market failure and government failure. Little attention has been paid to this issue. In this paper, we address it with a theoretical analysis and an empirical investigation on the relationship between China's industrial relocation in the early 1990s and energy consumption which is the primary source of CO 2 emission, an environmental externality that causes increasing concerns. The macro-policy analysis suggests that there would be a positive link between China's industrial relocation in the early 1990s and energy saving (and environmental externalities reduction). Using fixed-effect regression model and simulation method, we provide an empirical support to this argument. In order to further reduce environmental externalities and social cost in the process of industrial relocation, we provide policy suggestions as follows: First, strengthen the evaluation of environmental benefits/costs; Second, pay more attention to the coordinated social-economic development; Third, avoid long-lived investment in high-carbon infrastructure in areas with industries moved in; Fourth, address employment issue in the areas with industries moved out. - Research highlights: → Little attention has been paid to the linkage between industrial relocation and environmental externality. → Our macro-policy analysis suggests that there would be a positive link between China's industrial relocation in the early 1990s and energy saving (and environmental externalities reduction). → Using fixed-effect regression model and simulation method, we find a positive link between China's industrial relocation in the early 1990s and energy saving. → Policy suggestions to further reduce environmental externalities and social cost in the process of industrial relocation are discussed.

Parenting Stress in CHARGE Syndrome and the Relationship with Child Characteristics.

Science.gov (United States)

Wulffaert, Josette; Scholte, Evert M; Dijkxhoorn, Yvette M; Bergman, Jorieke E H; van Ravenswaaij-Arts, Conny M A; van Berckelaer-Onnes, Ina A

2009-08-01

This study investigates the parental perception of stress related to the upbringing of children with CHARGE syndrome and its association with behavioral and physical child characteristics. Parents of 22 children completed the Nijmegen Parenting Stress Index-Short, Developmental Behavior Checklist, and Dutch Vineland Screener 0-12 and reported their child's problems with hearing, vision and ability to speak. Parenting stress was high in 59% of the subjects. Behavioral problems on the depression, autism, self-absorbed and disruptive behavior scales correlated positively with parenting stress. A non-significant trend was found, namely higher stress among the parents of non-speaking children. No associations were found with other child characteristics, i.e. level of adaptive functioning and intellectual disability, auditory and visual problems, deafblindness, gender, and age. Raising a child with CHARGE syndrome is stressful; professional support is therefore essential for this population. More research into other possible influencing characteristics is needed to improve family-oriented interventions. Since CHARGE is a rare syndrome, closer international collaboration is needed, not only to expand the group of study subjects to increase statistical power, but also to harmonize research designs and measurement methods to improve the validity, the reliability, and the generalization of the findings.

Parent Stress and Perceptions of Language Development: Comparing Down Syndrome and Other Developmental Disabilities

Science.gov (United States)

Smith, Ashlyn L.; Romski, MaryAnn; Sevcik, Rose A.; Adamson, Lauren B.; Barker, R. Michael

2013-01-01

This study extended research on the Down syndrome advantage by examining differences in parent stress and parent perceptions of language development between 29 parents of young children with Down syndrome and 82 parents of children with other developmental disabilities. Parents of children with Down syndrome reported lower levels of total stress, child-related stress, and stress surrounding the parent-child interaction. Parents of children in both groups reported that they felt successful in their ability to impact their children’s communication development but did differ on perceptions of difficulty such that parents of children with Down syndrome perceived their children’s communication difficulties as less severe despite the children exhibiting similar language skills. Finally, after accounting for potential explanatory confounding variables, child diagnosis remained a significant predictor of parent stress and perceptions of language development. Results highlight the importance of considering etiology when assisting families raising a child with a disability. PMID:24753637

Establishment of the reliability and validity of the Stress Index for Children or Adolescents with Tourette Syndrome (SICATS).

Science.gov (United States)

Chao, Kuo-Yu; Wang, Huei-Shyong; Chang, Hsueh-Ling; Wang, Yi-Wen; See, Lai-Chu

2010-02-01

The aim of this study was to evaluate the validity and reliability of the stress index for 10-18-years-old children or adolescents with Tourette syndrome. Tourette syndrome is a chronic tic disorder, which occurs in childhood. Children with Tourette syndrome exhibit sudden and unexpected voices or movements that may have influence on their daily activities and cause interaction barriers for children with Tourette syndrome. Therefore, a self-report stress index is necessary for children with Tourette syndrome to quickly measure the stress they have. Eight experts rated appropriateness, comprehensiveness and relevance of the questionnaire to establish content validity. A total of 116 paediatric patients filled out the stress index for 10-18-years-old children or adolescents with Tourette syndrome to evaluate its construct validity using exploratory factor analysis and internal consistency. Data from 90 pairs of paediatric patients and their caregivers were used to evaluate the inter-rater reliability. The criterion validity index ranged from 80-98%. One item was deleted because of a small item-to-total correlation. Therefore, 26 items made up the final stress index for 10-18-years-old children or adolescents with Tourette syndrome. In exploratory factor analysis, four factors (unfairly treated, psychological, symptom control and future concern) were achieved and accounted for 52.3% of the total variance. Cronbach's alphas of the stress index for 10-18-years-old children or adolescents with Tourette syndrome were 0.89. The inter-rater reliability of stress Index for 10-18-years-old children or adolescents with Tourette syndrome (Pearson correlation coefficient between patients and their caregivers) was 0.56. The stress Index for 10-18-years-old children or adolescents with Tourette syndrome is a self-administered tool to assess the stress of children or adolescents with Tourette syndrome. Validity (content and construct) and reliability (internal consistency and inter

Medial tibial stress syndrome: a critical review

NARCIS (Netherlands)

Moen, Maarten H.; Tol, Johannes L.; Weir, Adam; Steunebrink, Miriam; de Winter, Theodorus C.

2009-01-01

Medial tibial stress syndrome (MTSS) is one of the most common leg injuries in athletes and soldiers. The incidence of MTSS is reported as being between 4% and 35% in military personnel and athletes. The name given to this condition refers to pain on the posteromedial tibial border during exercise,

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells.

Science.gov (United States)

Fonseca, Sonya G; Ishigaki, Shinsuke; Oslowski, Christine M; Lu, Simin; Lipson, Kathryn L; Ghosh, Rajarshi; Hayashi, Emiko; Ishihara, Hisamitsu; Oka, Yoshitomo; Permutt, M Alan; Urano, Fumihiko

2010-03-01

Wolfram syndrome is an autosomal-recessive disorder characterized by insulin-dependent diabetes mellitus, caused by nonautoimmune loss of beta cells, and neurological dysfunctions. We have previously shown that mutations in the Wolfram syndrome 1 (WFS1) gene cause Wolfram syndrome and that WFS1 has a protective function against ER stress. However, it remained to be determined how WFS1 mitigates ER stress. Here we have shown in rodent and human cell lines that WFS1 negatively regulates a key transcription factor involved in ER stress signaling, activating transcription factor 6alpha (ATF6alpha), through the ubiquitin-proteasome pathway. WFS1 suppressed expression of ATF6alpha target genes and repressed ATF6alpha-mediated activation of the ER stress response element (ERSE) promoter. Moreover, WFS1 stabilized the E3 ubiquitin ligase HRD1, brought ATF6alpha to the proteasome, and enhanced its ubiquitination and proteasome-mediated degradation, leading to suppression of ER stress signaling. Consistent with these data, beta cells from WFS1-deficient mice and lymphocytes from patients with Wolfram syndrome exhibited dysregulated ER stress signaling through upregulation of ATF6alpha and downregulation of HRD1. These results reveal a role for WFS1 in the negative regulation of ER stress signaling and in the pathogenesis of diseases involving chronic, unresolvable ER stress, such as pancreatic beta cell death in diabetes.

Microseismic Event Relocation and Focal Mechanism Estimation Based on PageRank Linkage

Science.gov (United States)

Aguiar, A. C.; Myers, S. C.

2017-12-01

Microseismicity associated with enhanced geothermal systems (EGS) is key in understanding how subsurface stimulation can modify stress, fracture rock, and increase permeability. Large numbers of microseismic events are commonly associated with hydroshearing an EGS, making data mining methods useful in their analysis. We focus on PageRank, originally developed as Google's search engine, and subsequently adapted for use in seismology to detect low-frequency earthquakes by linking events directly and indirectly through cross-correlation (Aguiar and Beroza, 2014). We expand on this application by using PageRank to define signal-correlation topology for micro-earthquakes from the Newberry Volcano EGS in Central Oregon, which has been stimulated two times using high-pressure fluid injection. We create PageRank signal families from both data sets and compare these to the spatial and temporal proximity of associated earthquakes. PageRank families are relocated using differential travel times measured by waveform cross-correlation (CC) and the Bayesloc approach (Myers et al., 2007). Prior to relocation events are loosely clustered with events at a distance from the cluster. After relocation, event families are found to be tightly clustered. Indirect linkage of signals using PageRank is a reliable way to increase the number of events confidently determined to be similar, suggesting an efficient and effective grouping of earthquakes with similar physical characteristics (ie. location, focal mechanism, stress drop). We further explore the possibility of using PageRank families to identify events with similar relative phase polarities and estimate focal mechanisms following Shelly et al. (2016) method, where CC measurements are used to determine individual polarities within event clusters. Given a positive result, PageRank might be a useful tool in adaptive approaches to enhance production at well-instrumented geothermal sites. Prepared by LLNL under Contract DE-AC52-07NA27344

Inflammatory cause of metabolic syndrome via brain stress and NF-κB

Science.gov (United States)

Cai, Dongsheng; Liu, Tiewen

2012-01-01

Metabolic syndrome, a network of medical disorders that greatly increase the risk for developing metabolic and cardiovascular diseases, has reached epidemic levels in many areas of today's world. Despite this alarming medicare situation, scientific understandings on the root mechanisms of metabolic syndrome are still limited, and such insufficient knowledge contributes to the relative lack of effective treatments or preventions for related diseases. Recent interdisciplinary studies from neuroendocrinology and neuroimmunology fields have revealed that overnutrition can trigger intracellular stresses to cause inflammatory changes mediated by molecules that control innate immunity. This type of nutrition-related molecular inflammation in the central nervous system, particularly in the hypothalamus, can form a common pathogenic basis for the induction of various metabolic syndrome components such as obesity, insulin resistance, and hypertension. Proinflammatory NF-κB pathway has been revealed as a key molecular system for pathologic induction of brain inflammation, which translates overnutrition and resulting intracellular stresses into central neuroendocrine and neural dysregulations of energy, glucose, and cardiovascular homeostasis, collectively leading to metabolic syndrome. This article reviews recent research advances in the neural mechanisms of metabolic syndrome and related diseases from the perspective of pathogenic induction by intracellular stresses and NF-κB pathway of the brain. PMID:22328600

The Metabolic Syndrome, Oxidative Stress, Environment, and Cardiovascular Disease: The Great Exploration

Science.gov (United States)

Hutcheson, Rebecca; Rocic, Petra

2012-01-01

The metabolic syndrome affects 30% of the US population with increasing prevalence. In this paper, we explore the relationship between the metabolic syndrome and the incidence and severity of cardiovascular disease in general and coronary artery disease (CAD) in particular. Furthermore, we look at the impact of metabolic syndrome on outcomes of coronary revascularization therapies including CABG, PTCA, and coronary collateral development. We also examine the association between the metabolic syndrome and its individual component pathologies and oxidative stress. Related, we explore the interaction between the main external sources of oxidative stress, cigarette smoke and air pollution, and metabolic syndrome and the effect of this interaction on CAD. We discuss the apparent lack of positive effect of antioxidants on cardiovascular outcomes in large clinical trials with emphasis on some of the limitations of these trials. Finally, we present evidence for successful use of antioxidant properties of pharmacological agents, including metformin, statins, angiotensin II type I receptor blockers (ARBs), and angiotensin II converting enzyme (ACE) inhibitors, for prevention and treatment of the cardiovascular complications of the metabolic syndrome. PMID:22829804

The Metabolic Syndrome, Oxidative Stress, Environment, and Cardiovascular Disease: The Great Exploration

Directory of Open Access Journals (Sweden)

Rebecca Hutcheson

2012-01-01

Full Text Available The metabolic syndrome affects 30% of the US population with increasing prevalence. In this paper, we explore the relationship between the metabolic syndrome and the incidence and severity of cardiovascular disease in general and coronary artery disease (CAD in particular. Furthermore, we look at the impact of metabolic syndrome on outcomes of coronary revascularization therapies including CABG, PTCA, and coronary collateral development. We also examine the association between the metabolic syndrome and its individual component pathologies and oxidative stress. Related, we explore the interaction between the main external sources of oxidative stress, cigarette smoke and air pollution, and metabolic syndrome and the effect of this interaction on CAD. We discuss the apparent lack of positive effect of antioxidants on cardiovascular outcomes in large clinical trials with emphasis on some of the limitations of these trials. Finally, we present evidence for successful use of antioxidant properties of pharmacological agents, including metformin, statins, angiotensin II type I receptor blockers (ARBs, and angiotensin II converting enzyme (ACE inhibitors, for prevention and treatment of the cardiovascular complications of the metabolic syndrome.

Stress and obesity/metabolic syndrome in childhood and adolescence.

Science.gov (United States)

Pervanidou, Panagiota; Chrousos, George P

2011-09-01

Chronic distress contributes to the development of obesity and comorbid states. Stress is the disturbance of the complex dynamic equilibrium that all organisms must maintain, and is associated with activation of the Stress system comprising of the hypothalamic-pituitary-adrenal axis and the arousal/sympathetic nervous systems. The stress system functions in a baseline circadian fashion and interacts with other systems of the organism to regulate a variety of behavioral, endocrine, metabolic, immune and cardiovascular functions. The experience of perceived or real uncontrollable intense and/or chronic stress (distress) may lead to several psychopathologic conditions, including anxiety, depressive and psychosomatic disorders, substance abuse, obesity and the metabolic syndrome, and osteoporosis, as well as impaired reproductive and immune functions. Developing children and adolescents are particularly vulnerable to the effects of chronic stress. Both behavioral and biological pathways are involved in the connection between chronic stress and obesity in adults and children. Emotional "comfort" eating, lack of sleep, impulsive behaviours and selection of specific foods often characterize stressed individuals. In addition to specific behaviours, dysregulation of the stress system through increased secretion of cortisol and catecholamines, especially in the evening hours, and in concert with concurrently elevated insulin concentrations, leads to development of central obesity, insulin resistance and the metabolic syndrome. In children, chronic alterations in cortisol secretion may have additional effects on cognitive and emotional development, timing of puberty and final stature. Obese children and adolescents are frequently entangled in a vicious cycle between distress, impairing self-image and distorted self-image, maintaining and worsening distress.

47 CFR 0.186 - Emergency Relocation Board.

Science.gov (United States)

2010-10-01

..., Defense and Emergency Preparedness Functions § 0.186 Emergency Relocation Board. (a) As specified in the... functions of the Commission. Relocation may be required to accommodate a variety of emergency scenarios... require the evacuation of FCC headquarters with little or no advance notice, but for only a short duration...

44 CFR 63.6 - Reimbursable relocation costs.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Reimbursable relocation costs. 63.6 Section 63.6 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT... OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.6 Reimbursable relocation...

The Four-Factor Taxonomy of Relocation Outcomes

Science.gov (United States)

Matthiesen, Jane Kirsten; Tissington, Patrick

2008-01-01

Relocation, an intraorganizational geographical transfer, can be used for human resource development (HRD) because of the positive developmental effects it can induce. It is, thus, important for HRD professionals to understand the implications of relocation to ensure it is used appropriately and effectively as an HRD technique. Research on…

[Acute Stress and Broken Heart Syndrome. A Case Report].

Science.gov (United States)

Vergel, Juliana; Tamayo-Orozco, Sebastián; Vallejo-Gómez, Andrés Felipe; Posada, María Teresa; Restrepo, Diana

Stress has been associated with an acute heart failure syndrome of important morbidity and mortality. Case report and non-systematic review of the relevant literature. A 65-year-old woman with a history of an untreated generalized anxiety disorder, whom after the violent death of her son presented with oppressive chest pain irradiated to neck and left superior extremity, lasting for more than 30minutes, initial clinical suspect suggests acute coronary syndrome. Tako-tsubo cardiomyopathy is characterized by a reversible left ventricular dysfunction and wall movement abnormalities, without any compromise of the coronary arteries, associated to high plasma levels of catecholamines which in most cases correlates with an acute stress of emotional or physical type. Tako-tsubo cardiomyopathy has to be considered by physicians among the differential diagnosis when facing a patient with suspected acute coronary syndrome, especially in post-menopausal women with a history of psychiatric comorbidities such as a generalized anxiety disorder. Copyright © 2016 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

Parenting Stress in CHARGE Syndrome and the Relationship with Child Characteristics

NARCIS (Netherlands)

Wulffaert, Josette; Scholte, Evert M.; Dijkxhoorn, Yvette M.; Bergman, Jorieke E. H.; van Ravenswaaij-Arts, Conny M. A.; van Berckelaer-Onnes, Ina A.

This study investigates the parental perception of stress related to the upbringing of children with CHARGE syndrome and its association with behavioral and physical child characteristics. Parents of 22 children completed the Nijmegen Parenting Stress Index-Short, Developmental Behavior Checklist,

Effect of housing relocation and neighborhood environment on adolescent mental and behavioral health.

Science.gov (United States)

Byck, Gayle R; Bolland, John; Dick, Danielle; Swann, Gregory; Henry, David; Mustanski, Brian

2015-11-01

This study examined whether relocating from a high-poverty neighborhood to a lower poverty neighborhood as part of a federal housing relocation program (HOPE VI; Housing Opportunities for People Everywhere) had effects on adolescent mental and behavioral health compared to adolescents consistently living in lower poverty neighborhoods. Sociodemographic, risk behavior, and neighborhood data were collected from 592 low-income, primarily African-American adolescents and their primary caregivers. Structured psychiatric interviews were conducted with adolescents. Prerelocation neighborhood, demographic, and risk behavior data were also included. Hierarchical Linear Modeling (HLM) was used to test associations between neighborhood variables and risk outcomes. HLM was used to test whether the effect of neighborhood relocation and neighborhood characteristics might explain differences in sexual risk taking, substance use, and mental health outcomes. Adolescents who relocated of HOPE VI neighborhoods (n = 158) fared worse than control group participants (n = 429) on most self-reported mental health outcomes. The addition of subjective neighborhood measures generally did not substantively change these results. Our findings suggest that moving from a high-poverty neighborhood to a somewhat lower poverty neighborhood is not associated with better mental health and risk behavior outcomes in adolescents. The continued effects of having grown up in a high-poverty neighborhood, the small improvements in their new neighborhoods, the comparatively short length of time they lived in their new neighborhood, and/or the stress of moving appears to worsen most of the mental health outcomes of HOPE VI compared to control group participants who consistently lived in the lower poverty neighborhoods. © 2015 Association for Child and Adolescent Mental Health.

Self-reported stress among adolescent siblings of individuals with autism spectrum disorder and Down syndrome.

Science.gov (United States)

Shivers, Carolyn M; McGregor, Casey; Hough, Ashlea

2017-11-01

Despite the prevalence of studies showing increased stress among mothers of individuals with autism spectrum disorders, few studies have examined general stress among typically developing siblings. This study used an online survey to compare the levels of self-reported stress between adolescent siblings of individuals with autism spectrum disorder and Down syndrome. Sibling of individuals with autism reported significantly more overall stress than did siblings of individuals with Down syndrome, as well as more stress specifically attributed to the brother/sister with autism. The two groups did not differ on perceived social support from family and friends. In linear regression models, the disability group (autism vs Down syndrome) was significantly related to sibling stress above and beyond target child behavior problems, perceived social support, and demographic factors. These results help shed light on the daily experiences of adolescent siblings of individuals with autism and call for more research into potential interventions to address increased stress levels.

Magnesium deficiency and metabolic syndrome: stress and inflammation may reflect calcium activation.

Science.gov (United States)

Rayssiguier, Yves; Libako, Patrycja; Nowacki, Wojciech; Rock, Edmond

2010-06-01

Magnesium (Mg) intake is inadequate in the western diet and metabolic syndrome is highly prevalent in populations around the world. Epidemiological studies suggest that high Mg intake may reduce the risk but the possibility of confounding factors exists, given the strong association between Mg and other beneficial nutriments (vegetables, fibers, cereals). The concept that metabolic syndrome is an inflammatory condition may explain the role of Mg.Mg deficiency results in a stress effect and increased susceptibility to physiological damage produced by stress. Stress activates the hypothalamic-pituitary-adrenal axis (HPA) axis and the sympathetic nervous system. The activation of the renin-angiotensin-aldosterone system is a factor in the development of insulin resistance by increasing oxidative stress. In both humans and rats, aldosteronism results in an immunostimulatory state and leads to an inflammatory phenotype. Stress response induces the release of large quantities of excitatory amino acids and activates the nuclear factor NFkappaB, promoting translation of molecules involved in cell regulation, metabolism and apoptosis. The rise in neuropeptides is also well documented. Stress-induced HPA activation has been identified to play an important role in the preferential body fat accumulation but evidence that Mg is involved in body weight regulation is lacking. One of the earliest events in the acute response to stress is endothelial dysfunction. Endothelial cells actively contribute to inflammation by elaborating cytokines, synthesizing chemical mediators and expressing adhesion molecules. Experimental Mg deficiency in rats induces a clinical inflammatory syndrome characterized by leukocyte and macrophage activation, synthesis of inflammatory cytokines and acute phase proteins, extensive production of free radicals. An increase in extracellular Mg concentration decreases inflammatory effects, while reduction in extracellular Mg results in cell activation. The

Somatic syndromes, insomnia, anxiety, and stress among sleep disordered breathing patients.

Science.gov (United States)

Amdo, Tshering; Hasaneen, Nadia; Gold, Morris S; Gold, Avram R

2016-05-01

We tested the hypothesis that the prevalence of somatic syndromes, anxiety, and insomnia among sleep disordered breathing (SDB) patients is correlated with their levels of somatic arousal, the symptoms of increased sympathetic nervous system tone under conditions of stress. We administered the Body Sensation Questionnaire (BSQ; a 17-item questionnaire with increasing levels of somatic arousal scored 17-85) to 152 consecutive upper airway resistance syndrome (UARS) patients and 150 consecutive obstructive sleep apnea/hypopnea (OSA/H) patients. From medical records, we characterized each patient in terms of the presence of syndromes and symptoms into three categories: somatic syndromes (six syndromes), anxiety (anxiety disorders, nightmares, use of benzodiazepines), and insomnia (sleep onset, sleep maintenance, and use of hypnotics). For the pooled sample of SDB patients, we modeled the correlation of the BSQ score with the presence of each syndrome/symptom parameter within each of the three categories, with adjustment for male vs. female. Mean BSQ scores in females were significantly higher than those in males (32.5 ± 11.1 vs. 26.9 ± 8.2; mean ± SD). Increasing BSQ scores significantly correlated with increasing prevalence rates of somatic syndromes (p insomnia (p ≤ 0.0001). In general, females had higher prevalence rates of somatic syndromes and symptoms of anxiety than males at any BSQ score while rates of insomnia were similar. In patients with SDB, there is a strong association between the level of somatic arousal and the presence of stress-related disorders like somatic syndromes, anxiety, and insomnia.

Development of Relocation Strategies Regarding Eruption Hazard in Mount Merapi

Directory of Open Access Journals (Sweden)

Rosdiana Puji Lestari

2015-09-01

Full Text Available The research was conducted to answer a questions: 1 how the relocation of the current strategy was carried out by the government 2 the problems that arise in the relocation which has yet to be resolved, 3 how the good concept of relocation so that these problems can be minimized. The research methodology used in this study combined quantitative and qualitative methods. Qualitative methods are used to explain the empirical facts that exist in each of these conditions in the relocation settlements. SWOT analysis is used to provide an overview of the strengths, weaknesses, opportunities and threats in the relocation of victims of Merapi. Information, facts and issues that arise in the study will be described, explained and analyzed primarily for the impact of residential relocation on social and economic life of the community. Relocation concept of the economic aspects of community empowerment efforts should be made related to community economic recovery after a change in livelihood. In addition, the potential of community mapping needs to be done by the government to be optimized and developed. From the aspect of government settlements seek to transfer ownership of land in the new settlement which may be the property of the citizens so that citizens obtain legal certainty while occupying the new settlement. The social aspects of the development potential of relocating residents and making it as a tourist village, residents need to support that relocation is no longer a newcomer, they have the same rights and obligations with citizens of another.

Heat stress and sudden infant death syndrome--stress gene expression after exposure to moderate heat stress

DEFF Research Database (Denmark)

Rohde, Marianne Cathrine; Corydon, Thomas Juhl; Hansen, Jakob

2013-01-01

The aim of the present study was to investigate stress gene expression in cultured primary fibroblasts established from Achilles tendons collected during autopsies from sudden infant death syndrome (SIDS) cases, and age-matched controls (infants dying in a traumatic event). Expression of 4 stress...... responsive genes, HSPA1B, HSPD1, HMOX1, and SOD2, was studied by quantitative reverse transcriptase PCR analysis of RNA purified from cells cultured under standard or various thermal stress conditions. The expression of all 4 genes was highly influenced by thermal stress in both SIDS and control cells. High...... interpersonal variance found in the SIDS group indicated that they represented a more heterogeneous group than controls. The SIDS group responded to thermal stress with a higher expression of the HSPA1B and HSPD1 genes compared to the control group, whereas no significant difference was observed...

Stress and resilience in functional somatic syndromes--a structural equation modeling approach.

Directory of Open Access Journals (Sweden)

Susanne Fischer

Full Text Available BACKGROUND: Stress has been suggested to play a role in the development and perpetuation of functional somatic syndromes. The mechanisms of how this might occur are not clear. PURPOSE: We propose a multi-dimensional stress model which posits that childhood trauma increases adult stress reactivity (i.e., an individual's tendency to respond strongly to stressors and reduces resilience (e.g., the belief in one's competence. This in turn facilitates the manifestation of functional somatic syndromes via chronic stress. We tested this model cross-sectionally and prospectively. METHODS: Young adults participated in a web survey at two time points. Structural equation modeling was used to test our model. The final sample consisted of 3'054 participants, and 429 of these participated in the follow-up survey. RESULTS: Our proposed model fit the data in the cross-sectional (χ2(21  = 48.808, p<.001, CFI  = .995, TLI  = .992, RMSEA  = .021, 90% CI [.013.029] and prospective analyses (χ2(21  =  32.675, p<.05, CFI  = .982, TLI  = .969, RMSEA  = .036, 90% CI [.001.059]. DISCUSSION: Our findings have several clinical implications, suggesting a role for stress management training in the prevention and treatment of functional somatic syndromes.

Relocation impacts of a major release from SRTC

International Nuclear Information System (INIS)

Blanchard, A.; Thompson, E.A.; Thompson, J.M.

1999-01-01

The relocation impacts of an accidental release, scenario 1-RD-3 , are evaluated for the Savannah River Technology Center. The extent of the area potentially contaminated to a level that would result in doses exceeding the relocation protective action guide(PAG)is calculated. The maximum calculated distance downwind from the accident at which the relocation PAG is exceeded is also determined. The consequences of the particulate portion of the release are evaluated using the HOTSPOT model and an EXCEL spreadsheet. The consequences of the tritium release are evaluated using UFOTRI

Strategic environmental policy when the governments are threatened by relocation

International Nuclear Information System (INIS)

Greaker, Mads

2003-01-01

This paper analyzes how the threat of relocation influences environmental policy. The stringency of environmental policy is determined in a game between two governments. There is one firm in each jurisdiction, and both firms threaten to relocate their production to the other jurisdiction. Because there is asymmetric information about the cost of relocation, the governments do not know the credibility of the threat. We compare the outcome of this game with the outcome of a game in which relocation is not possible. We find that the threat of relocation can increase both the level of environmental regulation and welfare. The profit tax level proves to be the most decisive for the result; that is, the higher the profit tax level, the lower the level of environmental regulation

The Stress-Metabolic Syndrome Relationship in Adolescents: An Examination of the Moderating Potential of Physical Activity.

Science.gov (United States)

Holmes, Megan E; Pivarnik, Jim; Pfeiffer, Karin; Maier, Kimberly S; Eisenmann, Joey C; Ewing, Martha

2016-10-01

The role of psychosocial stress in the development of obesity and metabolic syndrome is receiving increased attention and has led to examination of whether physical activity may moderate the stress-metabolic syndrome relationship. The current study examined relationships among physical activity, stress, and metabolic syndrome in adolescents. Participants (N = 126; 57 girls, 69 boys) were assessed for anthropometry, psychosocial stress, physical activity, and metabolic syndrome variables; t tests were used to examine sex differences, and regression analysis was used to assess relationships among variables controlling for sex and maturity status. Mean body mass index approached the 75th percentile for both sexes. Typical sex differences were observed for systolic blood pressure, time spent in moderate and vigorous physical activity, and perceived stress. Although stress was not associated with MetS (β = -.001, P = .82), a modest, positive relationship was observed with BMI (β = .20, P = .04). Strong relationships between physical activity and stress with MetS or BMI were not found in this sample. Results may be partially explained by overall good physical health status of the participants. Additional research in groups exhibiting varying degrees of health is needed.

Social Relationships, Psychosocial Adaptation, and Intrainstitutional Relocation of Elderly Men.

Science.gov (United States)

Tesch, Stephanie A.; And Others

1989-01-01

Studied intrainstitutional relocation of 40 men aged 53 to 91 and its effects on social integration, and behavioral and self-reported measures of psychosocial adaptation. Found in both longitudinal and time-lag analyses of pre- and post-relocation data, relocated men had lower scores on attitude toward aging dimension, fewer friends, and evidenced…

Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model.

Science.gov (United States)

Gupta, Amit; Vij, Garima; Sharma, Sameer; Tirkey, Naveen; Rishi, Praveen; Chopra, Kanwaljit

2009-01-01

Chronic fatigue syndrome, infection and oxidative stress are interrelated in epidemiological case studies. However, data demonstrating scientific validation of epidemiological claims regarding effectiveness of nutritional supplements for chronic fatigue syndrome are lacking. This study is designed to evaluate the effect of natural polyphenol, curcumin, in a mouse model of immunologically induced fatigue, where purified lipopolysaccharide (LPS) and Brucella abortus (BA) antigens were used as immunogens. The assessment of chronic fatigue syndrome was based on chronic water-immersion stress test for 10 min daily for 19 days and the immobility time was taken as the marker of fatigue. Mice challenged with LPS or BA for 19 days showed significant increase in the immobility time and hyperalgesia on day 19, as well as marked increase in serum tumor necrosis factor-alpha (TNF-alpha) levels. Concurrent treatment with curcumin resulted in significantly decreased immobility time as well as hyperalgesia. There was significant attenuation of oxidative stress as well as TNF-alpha levels. These findings strongly suggest that during immunological activation, there is significant increase in oxidative stress and curcumin can be a valuable option in the treatment of chronic fatigue syndrome.

Franchise Relocations, Expansions, and Mergers in Professional Sports Leagues

OpenAIRE

Daniel, Rascher

2008-01-01

All three sections in this chapter are interrelated. Expansions and relocations, especially in the early years of a league, are often the response to upstart rival leagues. More recently, relocations have occurred because another city offers a better facility lease regardless of whether the league as a whole is better off or not. Relocations, more so than expansions, often end up in court whether as an antitrust case accusing the league of monopolistically restricting business or as an emi...

Relocation: Its Effect on Health, Functioning and Mortality.

Science.gov (United States)

Borup, Jerry H.; And Others

1980-01-01

Relocation of older patients had a positive effect on hypochondria, stamina, hygiene, and daily functioning but no effect on health status. Self-health assessments, stamina, hypochondria, and hygiene had no effect on the mortality rate of relocated patients, but daily functioning did effect the mortality rate. (Author)

Medialt tibialt stress syndrom - en oversikt

OpenAIRE

Tømmerstrand, Jørn Yngve

2016-01-01

The objective of this thesis is to give a thorough presentation of medial tibial stress syndrome (MTSS) with emphasis on pathophysiology, aetiology, diagnostics and treatment options. MTSS is one of the most common exercise induced overuse injuries in athletes and military personnel. It is defined as exercise induced pain along a segment of at least 5 cm localized to the distal 2/3 of the posteromedial border of the tibia. The pathophysiological mechanisms of this condition is disputed. A tra...

Exercise-induced hyperthermia syndrome (canine stress syndrome in four related male English springer spaniels

Directory of Open Access Journals (Sweden)

Thrift E

2017-09-01

Full Text Available Elizabeth Thrift,1 Justin A Wimpole,2 Georgina Child,2 Narelle Brown,1 Barbara Gandolfi,3 Richard Malik4 1Animal Referral Hospital, 2Small Animal Specialist Hospital, Sydney, NSW, Australia; 3Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA; 4Centre for Veterinary Education, University of Sydney, Sydney, NSW, Australia Objective: This retrospective study describes the signalment, clinical presentation, diagnostic findings, and mode of inheritance in four young male English springer spaniel dogs with presumptive canine stress syndrome.Materials and methods: Appropriate cases were located through medical searches of medical records of two large private referral centers. Inclusion criteria comprised of English springer spaniel dogs with tachypnea and hyperthermia that subsequently developed weakness or collapse, with or without signs of hemorrhage, soon after a period of mild-to-moderate exercise. The pedigrees of the four affected dogs, as well as eleven related English springer spaniels, were then analyzed to determine a presumptive mode of genetic inheritance.Results: Four dogs met the inclusion criteria. All four were male, suggesting the possibility of a recessive sex-linked heritable disorder. Pedigree analysis suggests that more dogs may be potentially affected, although these dogs may have never had the concurrent triggering drug/activity/event to precipitate the clinical syndrome. There was complete resolution of clinical signs in three of the four dogs with aggressive symptomatic and supportive therapy, with one dog dying during treatment.Conclusion: Dogs with canine stress syndrome have the potential for rapid recovery if treated aggressively and the complications of the disease (eg, coagulopathy are anticipated. All four dogs were male, suggesting the possibility of a recessive sex-linked mode of inheritance. Further genetic analyses should be strongly considered by those

Individual relocation decisions after tornadoes: a multi-level analysis.

Science.gov (United States)

Cong, Zhen; Nejat, Ali; Liang, Daan; Pei, Yaolin; Javid, Roxana J

2018-04-01

This study examines how multi-level factors affected individuals' relocation decisions after EF4 and EF5 (Enhanced Fujita Tornado Intensity Scale) tornadoes struck the United States in 2013. A telephone survey was conducted with 536 respondents, including oversampled older adults, one year after these two disaster events. Respondents' addresses were used to associate individual information with block group-level variables recorded by the American Community Survey. Logistic regression revealed that residential damage and homeownership are important predictors of relocation. There was also significant interaction between these two variables, indicating less difference between homeowners and renters at higher damage levels. Homeownership diminished the likelihood of relocation among younger respondents. Random effects logistic regression found that the percentage of homeownership and of higher income households in the community buffered the effect of damage on relocation; the percentage of older adults reduced the likelihood of this group relocating. The findings are assessed from the standpoint of age difference, policy implications, and social capital and vulnerability. © 2018 The Author(s). Disasters © Overseas Development Institute, 2018.

Perceived stress correlates with visceral obesity and lipid parameters of the metabolic syndrome: A systematic review and meta-analysis.

Science.gov (United States)

Tenk, Judit; Mátrai, Péter; Hegyi, Péter; Rostás, Ildikó; Garami, András; Szabó, Imre; Hartmann, Petra; Pétervári, Erika; Czopf, László; Hussain, Alizadeh; Simon, Mária; Szujó, Szabina; Balaskó, Márta

2018-05-12

Perceived stress has been proposed as a risk factor of metabolic syndrome. However, correlations between perceived stress and parameters of the metabolic syndrome have not been properly analyzed despite extensive research data on the topic. Our current meta-analysis aimed to examine the mutual association between perceived stress of patients and parameters of metabolic syndrome. This systematic review has been registered on the PROSPERO database (registration number CRD42017055293). Eligible studies divided participants based on their stress level or on the presence of metabolic syndrome. They reported at least one parameter of the metabolic syndrome or the stress level of the participants measured with some stress scale. Data from 17 articles met the eligibility criteria and were included. Random effects model with the DerSimonian and Laird weighting methods was applied. I-squared indicator and Q test were performed to assess heterogeneity. Although the majority of individual studies failed to demonstrate correlations between stress and their analyzed parameters of metabolic syndrome, our meta-analysis showed a significant association between stress and BMI [average effect size (ES) with 95% confidence interval (95%CI), ES = 0.65, 95%CI 0.16, 1.14), waist circumference (ES = 1.84 cm, 95%CI 0.79, 2.89) and serum triglyceride level (ES = 7.52 mg/dl, 95%CI 0.07, 14.96). Additional analysis confirmed effects of stress on serum HDL (ES = - 1.699 mg/dl, 95%CI -2.966, -0.432) and diastolic blood pressure (ES = 1.04 mmHg, 95%CI 0.18, 1.89). No correlations were found for fasting glucose or systolic blood pressure. No association between metabolic syndrome and stress level of patients was detected either. The potentially key role of visceral obesity in the association between perceived stress and dyslipidemia or diastolic blood pressure are discussed together with potential moderators (e.g. gender-differences, variations in stress assessment and

Etiologic factors in the development of medial tibial stress syndrome: a review of the literature.

Science.gov (United States)

Tweed, Jo L; Avil, Steven J; Campbell, Jackie A; Barnes, Mike R

2008-01-01

Medial tibial stress syndrome is a type of exercise-induced leg pain that is common in recreational and competitive athletes. Although various studies have attempted to find the exact pathogenesis of this common condition, it remains unknown. Various theories in literature from 1976 to 2006 were reviewed using key words. Until recently, inflammation of the periosteum due to excessive traction was thought to be the most likely cause of medial tibial stress syndrome. This periostitis has been hypothesized by some authors to be caused by the tearing away of the muscle fibers at the muscle-bone interface, although there are several suggestions as to which, if any, muscle is responsible. Recent studies have supported the view that medial tibial stress syndrome is not an inflammatory process of the periosteum but instead a stress reaction of bone that has become painful.

β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.

Science.gov (United States)

Shang, Linshan; Hua, Haiqing; Foo, Kylie; Martinez, Hector; Watanabe, Kazuhisa; Zimmer, Matthew; Kahler, David J; Freeby, Matthew; Chung, Wendy; LeDuc, Charles; Goland, Robin; Leibel, Rudolph L; Egli, Dieter

2014-03-01

Wolfram syndrome is an autosomal recessive disorder caused by mutations in WFS1 and is characterized by insulin-dependent diabetes mellitus, optic atrophy, and deafness. To investigate the cause of β-cell failure, we used induced pluripotent stem cells to create insulin-producing cells from individuals with Wolfram syndrome. WFS1-deficient β-cells showed increased levels of endoplasmic reticulum (ER) stress molecules and decreased insulin content. Upon exposure to experimental ER stress, Wolfram β-cells showed impaired insulin processing and failed to increase insulin secretion in response to glucose and other secretagogues. Importantly, 4-phenyl butyric acid, a chemical protein folding and trafficking chaperone, restored normal insulin synthesis and the ability to upregulate insulin secretion. These studies show that ER stress plays a central role in β-cell failure in Wolfram syndrome and indicate that chemical chaperones might have therapeutic relevance under conditions of ER stress in Wolfram syndrome and other forms of diabetes.

THE PREVALENCE OF STRESS AND BURNOUT SYNDROME IN HOSPITAL DOCTORS AND FAMILY PHYSICIANS.

Science.gov (United States)

Stanetic, Kosana D; Savic, Suzana M; Racic, Maja

2016-11-01

Introducti on. Burnout syndrome is the result of chronic emotional stress. It is characterized by high levels of emotional exhaustion and depersonalization, and reduced level of personal accomplishment. The aim of this study was to determine the level of stress and risk ror burnout syndrome in doctors employed in health centers and hospitals, and to investigate the impact of socio-derrdgraphic characteristics on the level of stress and the o ccurrence of burnout syndrome. A cross-sectional study was conducted in the period from October I to December 31, 2015 in three health centers and in the University Clinical Center of the Republic of Srpska. The survey was anonymous. A socio-demographic questionnaire and a questionnaire for self-assessment of the level of stress and Maslach Burnout Inventory were used as research instruments. Out of 151 doctors included in the study, 49% were family physicians, and 51% were hospital doctors. The analysis of responses to questionnaires for self-assessment of stress level revealed that 51.7% of participants had high levels of stress (52.7% of family physicians, 50.6% of doctors working in hospital). A high degree of emotional exhaustion was found in 27.2% of participants (29.7% of fam ily physicians, 24.6% of doctors working in hospital), high depersonalization was found in 23.8% of participants (25.7% of family physicians, 22. 1% of doctors working in hospital), a low level of personal accomplishment was found in 39.7% of participants (37.8% of family physicians. 41.6% of doctors working in hospital). No statistically significant difference regarding stress degree, emotional exhaustion and depersonalizaion and personal accomplishment was found between hospital doctors and family physicians. The physicians aged over 45 years had a significantly (p = 0.030) higher level of emotional exhaustion than their younger colleagues. This study found that there was a high risk of burnout syndrome in physicians in the Republic of Srpska

Fuel pellet fracture and relocation

International Nuclear Information System (INIS)

Walton, L.A.; Husser, D.L.

1983-01-01

The model used to describe fuel pellet fracture and relocation is an important feature of a fuel performance computer code. This model becomes especially important if the computer code is principally to be used for the evaluation of pellet clad interaction. The fracture and relocation model being developed for the B and W fuel performance code FUMAC was derived from an extensive data base. Cross sections of irradiated fuel rods were photographically magnified and measured to determine the configuration of the fragments of the fractured fuel pellets. Data, representing a wide range of LWR fuel designs and as-manufactured mechanical configurations, were catalogued and systematically reduced and then correlated as a function of the likely independent variables. These correlations define the key phenomenological behavior patterns which the relocation model must duplicate and indicate which mechanistic approaches are viable explanations of this behavior. The data base covers the burnup range from approximately one to 35 GWd/mtU and linear heat rates from less than 100 to nearly 700 W/Cm. This paper presents the correlated data base and the methods used to derive and interpret it. It was determined from this data base that pellet cracking is initially both power level and burnup dependent but tends to saturate eventually with continued steady irradiation. Fuel pellet relocation was found to be much more extensive than would be deduced from thermal considerations alone. Even at very low burnups fuel fragments were found to move outward until restrained by the cladding. The results also suggest that changes in internal resistance to heat flow within the pellets due to the opening of cracks may be as important as peripheral gap changes to the thermal modeler. The transient response and thermal implications of this model are recommended as primary areas for future investigation

The TMI-2 core relocation: Heat transfer and mechanism

International Nuclear Information System (INIS)

Epstein, M.; Fauske, H.K.

1987-07-01

It is postulated that the collapse of the upper debris bed was the main cause of core failure and core material relocation during the TMI-2 accident. It is shown that this mechanism of core relocation can account for the timescale(s) and energy transfer rate inferred from plant instrumentation. Additional analysis suggests that the water in the lower half of the reactor vessel was subcooled at the onset of relocation, as subcooling serves to explain the final coolable configuration at the bottom of the TMI vessel

Section modulus is the optimum geometric predictor for stress fractures and medial tibial stress syndrome in both male and female athletes.

Science.gov (United States)

Franklyn, Melanie; Oakes, Barry; Field, Bruce; Wells, Peter; Morgan, David

2008-06-01

Various tibial dimensions and geometric parameters have been linked to stress fractures in athletes and military recruits, but many mechanical parameters have still not been investigated. Sedentary people, athletes with medial tibial stress syndrome, and athletes with stress fractures have smaller tibial geometric dimensions and parameters than do uninjured athletes. Cohort study; Level of evidence, 3. Using a total of 88 subjects, male and female patients with either a tibial stress fracture or medial tibial stress syndrome were compared with both uninjured aerobically active controls and uninjured sedentary controls. Tibial scout radiographs and cross-sectional computed tomography images of all subjects were scanned at the junction of the midthird and distal third of the tibia. Tibial dimensions were measured directly from the films; other parameters were calculated numerically. Uninjured exercising men have a greater tibial cortical cross-sectional area than do their sedentary and injured counterparts, resulting in a greater value of some other cross-sectional geometric parameters, particularly the section modulus. However, for women, the cross-sectional areas are either not different or only marginally different, and there are few tibial dimensions or geometric parameters that distinguish the uninjured exercisers from the sedentary and injured subjects. In women, the main difference between the groups was the distribution of cortical bone about the centroid as a result of the different values of section modulus. Last, medial tibial stress syndrome subjects had smaller tibial cross-sectional dimensions than did their uninjured exercising counterparts, suggesting that medial tibial stress syndrome is not just a soft-tissue injury but also a bony injury. The results show that in men, the cross-sectional area and the section modulus are the key parameters in the tibia to distinguish exercise and injury status, whereas for women, it is the section modulus only.

Mississippi Labor Mobility Demonstration Project--Relocating the Unemployed: Dimensions of Success.

Science.gov (United States)

Speight, John F.; And Others

The document provides an analysis of relocation stability of individuals relocated during the March, 1970-November, 1971 contract period. Data bases were 1,244 applicants with screening information and 401 individuals with follow-up interview information. Approximately one half were in new areas six months after being relocated. Reasons for…

The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response

OpenAIRE

Sukarieh, R.; Sonenberg, N.; Pelletier, J.

2009-01-01

Stress granules (SGs) arise as a consequence of cellular stress, contain stalled translation preinitiation complexes, and are associated with cell survival during environmental insults. SGs are dynamic entities with proteins relocating into and out of them during stress. Among the repertoire of proteins present in SGs is eukaryotic initiation factor 4E (eIF4E), a translation factor required for cap-dependent translation and that regulates a rate-limiting step for protein synthesis. Herein, we...

Relocation Impacts of an H-Separations Coil and Tube Failure

International Nuclear Information System (INIS)

Blanchard, A.

1999-01-01

The relocation impacts of an accidental release, scenario 1-RD-2.35, are evaluated for H-Separations. The extent of the area potentially contaminated to a level that would result in doses exceeding the relocation protective action guide (PAG) is calculated. The maximum calculated distance downwind from the accident at which the relocation PAG is exceeded is also determined. The consequences of the release are evaluated using the HOTSPOT model and an EXCEL spreadsheet

Relocation impacts of an H-Separations coil and tube failure

International Nuclear Information System (INIS)

Blanchard, A.

2000-01-01

The relocation impacts of an accidental release, scenario 1-RD-2.35, are evaluated for H-Separations. The extent of the area potentially contaminated to a level that would result in doses exceeding the relocation protective action guide (PAG) is calculated. The maximum calculated distance downwind from the accident at which the relocation PAG is exceeded is also determined. The consequences of the release are evaluated using the HOTSPOT model and an EXCEL spreadsheet

Aetiology, imaging and treatment of medial tibial stress syndrome

NARCIS (Netherlands)

Moen, M.H.

2012-01-01

The work contained is this thesis discusses aetiology, imaging and treatment of a common leg injury: medial tibial stress syndrome (MTSS). Although a common injury, the number of scientific articles on this topic is relatively low as is explained in chapter 1. This chapter also highlights that the

Wolff-Parkinson-White syndrome: a single exercise stress test might be misleading.

Science.gov (United States)

Salavitabar, Arash; Silver, Eric S; Liberman, Leonardo

2017-05-01

Risk stratification of patients with Wolff-Parkinson-White syndrome for sudden death is a complex process, particularly in understanding the utility of the repeat exercise stress test. We report a case of an 18-year-old patient who was found to have a high-risk pathway by both invasive and exercise stress testing after an initial exercise stress test showing beat-to-beat loss of pre-excitation.

Impact of psychological stress on irritable bowel syndrome.

Science.gov (United States)

Qin, Hong-Yan; Cheng, Chung-Wah; Tang, Xu-Dong; Bian, Zhao-Xiang

2014-10-21

Psychological stress is an important factor for the development of irritable bowel syndrome (IBS). More and more clinical and experimental evidence showed that IBS is a combination of irritable bowel and irritable brain. In the present review we discuss the potential role of psychological stress in the pathogenesis of IBS and provide comprehensive approaches in clinical treatment. Evidence from clinical and experimental studies showed that psychological stresses have marked impact on intestinal sensitivity, motility, secretion and permeability, and the underlying mechanism has a close correlation with mucosal immune activation, alterations in central nervous system, peripheral neurons and gastrointestinal microbiota. Stress-induced alterations in neuro-endocrine-immune pathways acts on the gut-brain axis and microbiota-gut-brain axis, and cause symptom flare-ups or exaggeration in IBS. IBS is a stress-sensitive disorder, therefore, the treatment of IBS should focus on managing stress and stress-induced responses. Now, non-pharmacological approaches and pharmacological strategies that target on stress-related alterations, such as antidepressants, antipsychotics, miscellaneous agents, 5-HT synthesis inhibitors, selective 5-HT reuptake inhibitors, and specific 5-HT receptor antagonists or agonists have shown a critical role in IBS management. A integrative approach for IBS management is a necessary.

Medial Tibial Stress Syndrome : Diagnosis, Treatment and Outcome Assessment

NARCIS (Netherlands)

Winters, M.

2017-01-01

Medial tibial stress syndrome (MTSS), also known as shin splints, is one of the most common sports injuries. Although 20% of the jumping and running athletes have MTSS at some point while engaging in sporting activities, we know little about it. There is a lack of knowledge regarding making the

[Association between occupational stress and aminotransferase activity in patients with metabolic syndrome].

Science.gov (United States)

Zhao, H; Song, L; Qiang, Y; Liu, H R; Qiu, F Y; Li, X Z; Song, H

2016-12-20

Objective: To investigate the association between occupational stress and activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in patients with metabolic syndrome. Methods: A case-control study was performed. According to inclusion and exclusion criteria, among the staff members of enterprises and public institutions aged 20~60 years who underwent physical examination in The Affiliated Hospital of Ningxia Medical University and The People's Hospital of Wuzhong from October 2011 to October 2012, 622 patients with metabolic syndrome who did not have a blood relationship with each other were enrolled as case group, and 600 healthy staff members who also did not have a blood relationshipwith each otherwere enrolled as control group. Questionnaire investigation, chronic occupational stress investigation, physical examination, and laboratory tests were performed for all subjects. Results: Compared with the control group, the case group had significantly higher serum levels and abnormal rates of AST and ALT ( t =-4.338 and-5.485, χ(2)=11.168 and 34.302, all P occupational stresses in both groups ( F =2.192 and 2.567, χ(2)=2.694 and 5.402, all P >0.05) , but there were significant differencesbetween the subgroups in all subjects ( F =5.005, χ(2)=6.398, all P occupational stresses in the case group, the control group, and all subjects ( F =0.845, 0.450, and 1.416, χ(2)=2.564, 1.344, and 3.147, all P >0.05) . The partial correlation analysis showed that the total score of occupational stress was positively correlated withthe serum level of AST ( r =0.071, P 0.05) , and that the serum level of AST was positively correlated with that of ALT ( r =0.736, P occupational stress was positively correlated with the serum level of AST ( r =0.069, P 0.05) , and the serum level of AST was positively correlated with that of ALT ( r =0.730, P occupational stress ( b =0.131, P =0.013) . Conclusion: Occupational stress is associated with increased serum level

Inverse relationship between the complexity of midfoot kinematics and muscle activation in patients with medial tibial stress syndrome

DEFF Research Database (Denmark)

Rathleff, M S; Samani, Afshin; Olesen, C G

2011-01-01

Medial tibial stress syndrome is a common overuse injury characterized by pain located on the medial side of the lower leg during weight bearing activities such as gait. The purpose of this study was to apply linear and nonlinear methods to compare the structure of variability of midfoot kinematics...... and surface electromyographic (SEMG) signals between patients with medial tibial stress syndrome and healthy controls during gait. Fourteen patients diagnosed with medial tibial stress syndrome and 11 healthy controls were included from an orthopaedic clinic. SEMG from tibialis anterior and the soleus muscles...... as well as midfoot kinematics were recorded during 20 consecutive gait cycles. Permuted sample entropy and permutation entropy were used as a measure of complexity from SEMG signals and kinematics. SEMG signals in patients with medial tibial stress syndrome were characterized by higher structural...

Patient safety and nursing: interface with stress and Burnout Syndrome.

Science.gov (United States)

Rodrigues, Cláudia Cristiane Filgueira Martins; Santos, Viviane Euzébia Pereira; Sousa, Paulo

2017-01-01

To analyze studies on stress, Burnout Syndrome, and patient safety in the scope of nursing care in the hospital environment. This was an integrative literature review. Data collection was performed in February 2016 in the following databases: Medical Literature Analysis and Retrieval System Online - PubMed/MEDLINE, Latin American and Caribbean Literature in Health Sciences - LILACS. Ten scientific productions were selected, which listed that factors contributing to stress and Burnout Syndrome of nursing professionals are the work environment as a source of stress, and excessive workload as a source of failures. The analysis found that the stress and Burnout Syndrome experienced by these professionals lead to greater vulnerability and development of unsafe care, and factors such as lack of organizational support can contribute to prevent these failures. Analisar estudos que versam sobre o estresse e Síndrome de Burnout, bem como a segurança do paciente no âmbito da assistência de enfermagem no ambiente hospitalar. Tratou-se de uma revisão integrativa de literatura. O levantamento dos dados foi efetuado nas bases de dados Medical Literature Analysis and Retrieval System Online - PubMed / MEDLINE, Literatura Latino-Americana e do Caribe em Ciências da Saúde -LILACS em fevereiro de 2016. Foram selecionadas10 produções científicas que apontaram que os fatores que contribuem para o estresse e a Síndrome de Burnout dos profissionais de enfermagem são o ambiente de trabalho como fonte de estresse e a carga de trabalho excessiva como geradora de falhas. A análise apontou que o estresse e a Síndrome de Burnout vivenciada por esses profissionais acarretam maior vulnerabilidade ao desenvolvimento de uma assistência insegura e que fatores como a falta de apoio organizacional podem contribuir para dirimir essas falhas.

Relationship between oxidative stress and "burning mouth syndrome" in female patients: a scientific hypothesis.

Science.gov (United States)

Tatullo, M; Marrelli, M; Scacco, S; Lorusso, M; Doria, S; Sabatini, R; Auteri, P; Cagiano, R; Inchingolo, F

2012-09-01

Burning Mouth Syndrome (BMS) is characterized by burning sensation and pain in the mouth with or without inflammatory signs and specific lesions. Aim of the present study was to investigate about a possible correlation between the Burning Mouth Syndrome and oxidative stress. We recruited 18 healthy female patients between 54 and 68 years of age with a diagnosis of Burning Mouth Syndrome. Oxidative stress assessment was performed by means of an integrated analytical system composed of a photometer and a mini-centrifuge (FRAS4, H and D s.r.l., Parma, Italy). Samples of whole capillary blood were taken by a finger puncture in a heparinized tube and immediately centrifuged; a small amount of samples plasma (10 microL) were thereafter tested for total oxidant capacity (d-ROMs test) and biological antioxidant potential as iron-reducing activity (BAP test) (Diacron International s.r.l., Grosseto, Italy). Our results indicate that female patients affected by Burning Mouth Syndrome show significantly different d-ROMs and BAP levels, similar to those present in oxidative stress condition with respect to the general population. It was also emphasized that, after the most painful phase, the levels representing the present oxidative stress, progressively return to normal, even if still significantly higher 7 days after, with respect to the normal population. No similar study was performed up to now. This study confirms the effectiveness of antioxidant treatments in the patients affected by BMS, in order to prevent or decrease the onset of oxidative stress and the consequent increased risk of oxidative-related systemic diseases.

Stressful life events and psychological dysfunction in complex regional pain syndrome type I

NARCIS (Netherlands)

Geertzen, JHB; de Bruijn-Kofman, AT; de Bruijn, HP; van de Wiel, HBM; Dijkstra, PU

Objective: To determine to what extent stressful life events and psychological dysfunction play a role in the pathogenesis of Complex Regional Pain Syndrome type I (CRPS). Design: A comparative study between a CRPS group and a control group. Stressful life events and psychological dysfunction

A Heuristic Procedure for the Outbound Container Relocation Problem during Export Loading Operations

Directory of Open Access Journals (Sweden)

Roberto Guerra-Olivares

2015-01-01

Full Text Available During export ship loading operations, it is often necessary to perform relocation movements with containers that interfere with access to the desired container in the ship loading sequence. This paper presents a real-time heuristic procedure for the container relocation problem employing reachstacker vehicles as container handling equipment. The proposed heuristic searches for good relocation coordinates within a set of nearby bays. The heuristic has a parameter that determines how far from the original bay a container may be relocated. The tradeoff between reducing relocation movements and limiting vehicle travel distances is examined and the performance of the heuristic is compared with a common practice in the smaller container terminals in Chile and Mexico. Finally, a mathematical model for the container relocation problem is presented.

Parent stress across molecular subtypes of children with Angelman syndrome.

Science.gov (United States)

Miodrag, N; Peters, S

2015-09-01

Parenting stress has been consistently reported among parents of children with developmental disabilities. However, to date, no studies have investigated the impact of a molecular subtype of Angelman syndrome (AS) on parent stress, despite distinct phenotypic differences among subtypes. Data for 124 families of children with three subtypes of AS: class I and II deletions (n = 99), imprinting centre defects (IC defects; n = 11) and paternal uniparental disomy (UPD; n = 14) were drawn from the AS Rare Diseases Clinical Research Network (RDCRN) database and collected from five research sites across the Unites States. The AS study at the RDCRN gathered health information to understand how the syndrome develops and how to treat it. Parents completed questionnaires on their perceived psychological stress, the severity of children's aberrant behaviour and children's sleep patterns. Children's adaptive functioning and developmental levels were clinically evaluated. Child-related stress reached clinical levels for 40% of parents of children with deletions, 100% for IC defects and 64.3% for UPD. Sleep difficulties were similar and elevated across subtypes. There were no differences between molecular subtypes for overall child and parent-related stress. However, results showed greater isolation and lack of perceived parenting skills for parents of children with UPD compared with deletions. Better overall cognition for children with deletions was significantly related to more child-related stress while their poorer adaptive functioning was associated with more child-related stress. For all three groups, the severity of children's inappropriate behaviour was positively related to different aspects of stress. How parents react to stress depends, in part, on children's AS molecular subtype. Despite falling under the larger umbrella term of AS, it is important to acknowledge the unique aspects associated with children's molecular subtype. Identifying these factors can

Restoration of nuclear-import failure caused by triple A syndrome and oxidative stress

International Nuclear Information System (INIS)

Kiriyama, Takao; Hirano, Makito; Asai, Hirohide; Ikeda, Masanori; Furiya, Yoshiko; Ueno, Satoshi

2008-01-01

Triple A syndrome is an autosomal recessive neurological disease, mimicking motor neuron disease, and is caused by mutant ALADIN, a nuclear-pore complex component. We recently discovered that the pathogenesis involved impaired nuclear import of DNA repair proteins, including DNA ligase I and the cerebellar ataxia causative protein aprataxin. Such impairment was overcome by fusing classical nuclear localization signal (NLS) and 137-aa downstream sequence of XRCC1, designated stretched NLS (stNLS). We report here that the minimum essential sequence of stNLS (mstNLS) is residues 239-276, downsized by more than 100 aa. mstNLS enabled efficient nuclear import of DNA repair proteins in patient fibroblasts, functioned under oxidative stress, and reduced oxidative-stress-induced cell death, more effectively than stNLS. The stress-tolerability of mstNLS was also exerted in control fibroblasts and neuroblastoma cells. These findings may help develop treatments for currently intractable triple A syndrome and other oxidative-stress-related neurological diseases, and contribute to nuclear compartmentalization study

Burnout Syndrome and Demotivation Among Health Care Personnel. Managing Stressful Situations: The Importance of Teamwork.

Science.gov (United States)

García-Campayo, J; Puebla-Guedea, M; Herrera-Mercadal, P; Daudén, E

2016-06-01

Almost one-third of our lives is spent in the workplace, where much of our interaction with others takes place and where we are exposed to stressful situations. Work-related stress has consequences for the individual's physical and mental health. Stress and professional burnout syndrome are the main consequences of work situations characterized by a constant state of tension. Stress is the second leading cause of absenteeism in the European Union, and around 12% of European workers are currently affected by burnout syndrome. It is therefore vital to identify demotivated and stressed staff in both large organizations (hospitals and clinics) and smaller centers (private practices) so as to facilitate preventive measures and ensure early intervention in situations of stress, with a view to improving the performance of work teams. Copyright © 2015 AEDV. Published by Elsevier España, S.L.U. All rights reserved.

The role of oxidative stress on the pathophysiology of metabolic syndrome

Directory of Open Access Journals (Sweden)

Fabiane Valentini Francisqueti

Full Text Available Summary Metabolic syndrome (MetS has a high prevalence around the world. Considering the components used to classify MetS, it is clear that it is closely related to obesity. These two conditions begin with an increase in abdominal adipose tissue, which is metabolically more active, containing a greater amount of resident macrophages compared to other fat deposits. Abdominal adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving MetS components, namely insulin resistance, hypertension and hyperlipidemia. One way to block the effects of oxidative stress would be through the antioxidant defense system, which offsets the excess free radicals. It is known that individuals with metabolic syndrome and obesity have high consumption of fats and sugars originated from processed foods containing high levels of sodium as well as low intake of fruits and vegetables, thus maintaining a state of oxidative stress, that can speed up the onset of MetS. Healthy eating habits could prevent or delay MetS by adding antioxidant-rich foods into the diet.

The Relationship between Irritable Bowel Syndrome, Depression, Anxiety, and Stress among Sample of Irritable Bowel Patients - Predictive Study

OpenAIRE

Osama Hasan Gaber

2016-01-01

This study aimed to examine the relationship of irritable bowel syndrome, anxiety, depression and stress among a sample of78 IBS patients (Rome III Diagnostic Criteria for Irritable Bowel Syndrome), anxiety symptoms scale, Depression symptoms scale, and stress scale (prepared by the researcher) were used Pearson Correlation Coefficient showed that there are statistically significant relationship between IBS and Anxiety, Depression and Stress (P?=0.01). The Regression and Prediction Coefficien...

Reversible Stress Cardiomyopathy Presenting as Acute Coronary Syndrome with Elevated Troponin in the Absence of Regional Wall Motion Abnormalities: A Forme Fruste of Stress Cardiomyopathy?

Directory of Open Access Journals (Sweden)

Mahesh Anantha Narayanan

2014-01-01

Full Text Available We present a case of reversible stress cardiomyopathy in a surgical patient, described here as a forme fruste due to its atypical features. It is important to recognize such unusual presentation of stress cardiomyopathy that mimics acute coronary syndrome. Stress cardiomyopathy commonly presents as acute coronary syndrome and is characterized by typical or atypical variants of regional wall motion abnormalities. We report a 60-year-old Caucasian male with reversible stress cardiomyopathy following a sternal fracture fixation. Although the patient had several typical features of stress cardiomyopathy including physical stress, ST-segment elevation, elevated cardiac biomarkers and normal epicardial coronaries, there were few features that were atypical, including unusual age, gender, absence of regional wall motion abnormalities, high lateral ST elevation, and high troponin-ejection fraction product. In conclusion, this could represent a forme fruste of stress cardiomyopathy.

Means for Transferring Knowledge in the Relocation of Manufacturing Units

DEFF Research Database (Denmark)

Yang, Cheng; Madsen, Erik Skov; Liangsiri, Jirapha

2009-01-01

The global spread of production makes companies relocating their manufacturing units to achieve economies of scale, enjoy low-cost labor, or access to new markets. For the relocation, not only equipments, systems and facilities, need to be moved, but also operational knowledge and experience. Based...

Quotas, Relocation and Jobs

Science.gov (United States)

Blumrosen, Alfred

1975-01-01

This testimony, before a public hearing of the New York City Commission on Human Rights in May 1974, has two express focuses: one is the question of quotas, and the other is the problem of relocation of plants and facilities in the suburban areas and the consequent difficulties minorities face in retaining equal employment opportunities.…

Infectious Disease Prevalence and Factors Associated with Upper Respiratory Infection in Cats Following Relocation

Directory of Open Access Journals (Sweden)

Mehnaz Aziz

2018-06-01

Full Text Available Feline relocation is used increasingly in animal welfare to decrease shelter euthanasia rates and increase positive outcomes. Concerns about infectious disease introduction and transmission are often expressed; however, little research has been conducted on even the baseline prevalence of infectious disease following relocation. This study, which collected data on 430 cats relocated through an established program over 7 months, evaluated the prevalence of upper respiratory infection (URI, feline panleukopenia virus (FPV and dermatophytosis at one destination agency. The period prevalence was 25.8% for URI, 1.6% for FPV and 0.9% for dermatophytosis. Mixed-effects logistic regression was performed to investigate factors associated with URI. Younger age, increased time in transport, and increased length of stay at the destination agency were associated with increased URI prevalence following relocation. The findings of this study reveal that certain highly contagious and environmentally persistent infectious diseases, such as FPV and dermatophytosis, are uncommon following relocation in an established program; however, URI in relocated cats should be proactively managed. Animal welfare agencies can use this information to guide shelter and relocation operations and mitigate the impact of URI in relocated cats.

Environmental assessment for relocation of NREL research experiments

International Nuclear Information System (INIS)

1992-06-01

In compliance with the National Environmental Policy Act (NEPA), the Department of Energy (DOE) has prepared this environmental assessment (DOE/EA-0619) to evaluate the environmental consequences associated with the conduct of ongoing research activities of its National Renewable Energy Laboratory proposed to be relocated to leased commercial laboratory and warehouse space at 6800 Joyce Sum, in Arvada, Colorado. NREL is currently leasing space in Golden, Colorado, for conduct of the research actions discussed in the EA. The research project proposed for relocation is the Amorphous silicon Deposition Laboratory (ASDL). Additionally, it may be financially desirable to relocate the Scanning Hartman Optical Tester (SHOT) and the Whole Building Test Facility at a later date, therefore, the consequences of their operation at the proposed facility is evaluated in the EA to support such future decisions. The new location can also provide additional warehouse space required by NREL

Knowledge Transfer and Manufacturing Relocation in International Manufacturing Networks

DEFF Research Database (Denmark)

Madsen, Erik Skov

2014-01-01

This paper is built on six longitudinal case studies of knowledge transfer in manufacturing relocation. By focusing on tacit and explicit knowledge the paper introduces a model for identification of knowledge in relation to four task situations on the shop floor in a manufacturing environment...... after relocation. Finally the paper discusses how “dispatching capacity” and “absorptive capacity” can improve the process....

Job stress models for predicting burnout syndrome: a review.

Science.gov (United States)

Chirico, Francesco

2016-01-01

In Europe, the Council Directive 89/391 for improvement of workers' safety and health has emphasized the importance of addressing all occupational risk factors, and hence also psychosocial and organizational risk factors. Nevertheless, the construct of "work-related stress" elaborated from EU-OSHA is not totally corresponding with the "psychosocial" risk, that is a broader category of risk, comprising various and different psychosocial risk factors. The term "burnout", without any binding definition, tries to integrate symptoms as well as cause of the burnout process. In Europe, the most important methods developed for the work related stress risk assessment are based on the Cox's transactional model of job stress. Nevertheless, there are more specific models for predicting burnout syndrome. This literature review provides an overview of job burnout, highlighting the most important models of job burnout, such as the Job Strain, the Effort/Reward Imbalance and the Job Demands-Resources models. The difference between these models and the Cox's model of job stress is explored.

24 CFR 1003.209 - Prohibition on use of assistance for employment relocation activities.

Science.gov (United States)

2010-04-01

... employment relocation activities. (a) Prohibition. ICDBG funds may not be used to directly assist a business, including a business expansion, in the relocation of a plant, facility, or operation from one Identified... business to undertake one or more of these activities as a condition of the business relocating a facility...

[Corticotropic axis and chronic stress in abdominal obesity and metabolic syndrome].

Science.gov (United States)

Boullu-Ciocca, S; Verger, P; Bocquier, A; Oliver, C

2005-12-03

Several indicators of corticotropic axis hyperactivity have been observed in common abdominal obesity, which is clinically similar to the obesity found in Cushing's syndrome. Corticotropic axis hyperactivity may be involved in the development and metabolic and cardiovascular complications of abdominal obesity. Several mechanisms may be responsible for this hormonal dysregulation: genetic, lifestyle, and nutritional factors, and chronic stress. We note the necessity of methodologically-impeccable clinical studies for an objective evaluation of the role of stress in obesity.

20 CFR 627.215 - Relocation.

Science.gov (United States)

2010-04-01

... the original location. (b) For 120 days after the commencement or the expansion of commercial... original location. (c) For the purposes of this section, relocating establishment means a business entity... review should include names under which the establishment does business, including successors-in-interest...

Divided parents, shared children
Conflicting approaches to relocation disputes in the USA

Directory of Open Access Journals (Sweden)

Theresa Glennon

2008-06-01

Full Text Available Custody relocation disputes pose intractable dilemmas for courts in a highly mobile society. The custodial parent, most often a woman, seeks self-determination, freedom of movement and a continued custodial relationship with the child. The non-custodial parent seeks to preserve a geographically close relationship with the child. Courts must identify the best interests of the children amidst these multiple and conflicting interests. They make decisions that may determine the course of custodial parents’ lives, affecting remarriage, employment, education, and proximity to family. A narrow doctrinal focus on children’s best interests ignores these key aspects of relocation disputes. This article examines the varied legislative and judicial approaches to relocation disputes in the US and proposed principles for resolution of these disputes. It reviews scholarship analyzing relocation disputes from a wide range of perspectives, including: conflicting social science research; competing ideologies of the post-divorce family; alternative dispute resolution; parents’ constitutional rights; domestic violence victims; and proposals to eliminate geographic presumptions and remedy the economic effect of restraints on relocation. Relocation doctrine in the US should be realigned to address these complex perspectives. States should also assist post-divorce families to support children through the common experience of relocation.

The appraisal of chronic stress and the development of the metabolic syndrome

DEFF Research Database (Denmark)

Bergmann, N; Gyntelberg, F; Faber, J

2014-01-01

. Thirty-nine studies were included. An association between chronic psychosocial stress and the development of MES was generally supported. Regarding the four elements of MES: i) weight gain: the prospective studies supported etiological roles for relationship stress, perceived stress, and distress, while...... the studies on work-related stress (WS) showed conflicting results; ii) dyslipidemi: too few studies on psychosocial stress as a risk factor for dyslipidemia were available to draw a conclusion; however, a trend toward a positive association was present; iii) type 2 diabetes mellitus (DM2): prospective......Chronic psychosocial stress has been proposed as a risk factor for the development of the metabolic syndrome (MES). This review gives a systematic overview of prospective cohort studies investigating chronic psychosocial stress as a risk factor for incident MES and the individual elements of MES...

24 CFR 570.210 - Prohibition on use of assistance for employment relocation activities.

Science.gov (United States)

2010-04-01

... relocation activities. (a) Prohibition. CDBG funds may not be used to directly assist a business, including a business expansion, in the relocation of a plant, facility, or operation from one LMA to another LMA if the... business to undertake one or more of these activities as a condition of the business relocating a facility...

30 CFR 780.33 - Relocation or use of public roads.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Relocation or use of public roads. 780.33... PLAN § 780.33 Relocation or use of public roads. Each application shall describe, with appropriate maps... line of any public road, except where mine access or haul roads join that right-of-way; or (b...

Relocating a Company within the EU

DEFF Research Database (Denmark)

Werlauff, Erik

2008-01-01

This article analyses how a public or private limited company can be relocated in another EU country via establishment of a subsidiary in the second country, followed by a reverse vertical merger (the parent ceases to exist and the subsidiary is the continuing company). The consideration for the ...... for the merger is shares in the subsidiary, which can be effected by giving the parent company's shares in the subsidiary to the parent company's shareholders, but after the shares have taken a brief respite in the subsidiary as own shares......This article analyses how a public or private limited company can be relocated in another EU country via establishment of a subsidiary in the second country, followed by a reverse vertical merger (the parent ceases to exist and the subsidiary is the continuing company). The consideration...

The Future of Earthquake Relocation Tools

Science.gov (United States)

Lecocq, T.; Caudron, C.

2010-12-01

Many scientists around the world use earthquake relocation software for their research. Some use "known" software like HYPODD or COMPLOC, while others use their own algorithms and codes. Often, beginners struggle to get one tool running or to properly configure input parameters. This Poster will be witness of debates that will take place during the Meeting, for example adressing questions like "Which program for which application?" ; "Standardized In/Outs?" , "Tectonic / Volcanic / Other ?" ; "All programs inside one single Super-Package?" ; "Common/Base Bibliography for the Relocation-Beginner?" ; "Continuous or Layered Velocity Model?" etc... We will also present the scheme of a Super-Package we are working on, grouping HYPODD [Waldhauser 2001], COMPLOC [Lin&Shearer 2006], LOTOS [Koulakov 2009] ; allowing standard in/outs for the 3 programs, and thus, the comparison of their outputs.

Fuel relocation modeling in the SAS4A accident analysis code system

International Nuclear Information System (INIS)

Tentner, A.M.; Miles, K.J.; Kalimullah; Hill, D.J.

1986-01-01

The SAS4A code system has been designed for the analysis of the initial phase of Hypothetical Core Disruptive Accidents (HCDAs) up to gross melting or failure of the subassembly walls. During such postulated accident scenarios as the Loss-of-Flow (LOF) and Transient-Overpower (TOP) events, the relocation of the fuel plays a key role in determining the sequence of events and the amount of energy produced before neutronic shutdown. This paper discusses the general strategy used in modelong the various phenomena which lead to fuel relocation and presents the key fuel relocation models used in SAS4A. The implications of these models for the whole-core accident analysis as well as recent results of fuel relocation are emphasized. 12 refs

Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive extract.

Science.gov (United States)

Gupta, Amit; Vij, Garima; Chopra, Kanwaljit

2010-09-14

Various putative theories involved in the development of chronic fatigue syndrome revolve around the role of stress, infection and oxidative stress. Scientific evidence highlighting the protective role of nutritional supplements in chronic fatigue syndrome is lacking. Based on these assumptions, the present study was designed to evaluate the effect of olive extract in a mouse model of immunologically-induced fatigue, wherein purified lipopolysaccharide (LPS) and Brucella abortus (BA) antigen were used as immunogens. The assessment of chronic fatigue syndrome was based on immobility period during chronic water-immersion stress test for 10 min daily. The stress-induced hyperalgesia was measured by tail withdrawal latency. Mice challenged with LPS or BA for 19 days showed significant increase in the immobility time, hyperalgesia and oxidative stress on the 19th day. Serum tumor necrosis factor-alpha (TNF-α) levels were also markedly increased with LPS or BA challenge. Concurrent treatment with olive extract resulted in a significant decrease in the immobility time as well as hyperalgesia. There was significant attenuation of oxidative stress as well as serum TNF-α levels. The results of the present study strongly indicate the role of oxidative stress and immunological activation in the pathophysiology of chronic fatigue syndrome and highlight the valuable role of olive extract in combating chronic fatigue syndrome. Copyright © 2010 Elsevier B.V. All rights reserved.

Factors and aspects of the relocation strategies of companies

Directory of Open Access Journals (Sweden)

Serghei Margulescu

2013-05-01

Full Text Available In the last two decades there have been significant changes in the factors that determine the geographic location or relocation of R &D, production and marketing of all transnational companies. Supply chains have expanded to new areas of the globe and big traditional providers have also expanded their global presence by an increasing trend of co-localization with their main customers. Contract manufacturers have multiplied and strengthened, expanding their geographical distribution. A more obvious trend was that of the geographic dispersion of other global value chain functions such as business services and logistics support functions. Relocation to countries with cheap labor is not always a successful strategy. Therefore the decision to relocate in international geographical area, regardless of the structure formula, offshoring or outsourcing, must be based on a more diverse set of factors.

30 CFR 784.18 - Relocation or use of public roads.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Relocation or use of public roads. 784.18... PLAN § 784.18 Relocation or use of public roads. Each application shall describe, with appropriate maps...-of-way line of any public road, except where mine access or haul roads join that right-of-way; or (b...

Respite Care, Stress, Uplifts, and Marital Quality in Parents of Children with Down Syndrome

Science.gov (United States)

Norton, Michelle; Dyches, Tina Taylor; Harper, James M.; Roper, Susanne Olsen; Caldarella, Paul

2016-01-01

Parents of children with disabilities are at risk for high stress and low marital quality; therefore, this study surveyed couples (n = 112) of children with Down syndrome (n = 120), assessing whether respite hours, stress, and uplifts were related to marital quality. Structural equation modeling indicated that respite hours were negatively related…

Adaptive Skills, Behavior Problems, and Parenting Stress in Mothers of Boys with Fragile X Syndrome

Science.gov (United States)

Sarimski, Klaus

2010-01-01

The relationship of temperament, atypical behaviors, and adaptive behavior of young boys with Fragile X syndrome on mothers' parenting stress was analyzed. Twenty-six boys with Fragile X syndrome (30-88 months of age) participated. The overall development of the participants was significantly delayed with a specific profile of adaptive behaviors…

The Problem of Faculty Relocation.

Science.gov (United States)

Tabachnick, Stephen E.

1992-01-01

A faculty move to a new campus can be traumatic, but colleges and universities can take steps to lessen the strain. Solutions to faculty relocation problems should be a standard part of any hiring package, not left to chance and individual negotiation. Some problems are inexpensive and easy to solve. (MSE)

Wages and commuting: quasi-natural experiments' evidence from firms that relocate

DEFF Research Database (Denmark)

Mulalic, Ismir; N. Van Ommeren, Jos; Pilegaard, Ninette

We examine workers' compensating differentials for commuting distance in a quasi-natural experiment setting by examining how wages of workers belonging to the same firm respond to changes in commuting distance induced by firm relocations. This setup enables us to test for the relevance of non...... explanations. We focus on wage changes in the year after, as well as three years after, the firm relocation. We demonstrate that a one km increase in commuting distance induces a wage increase of only 0.06 percent in the year after the relocation, but a more substantial wage increase of about 0.2 percent three...

Evaluation of relocation of unionid mussels into artificial ponds

Science.gov (United States)

Newton, T.J.; Monroe, E.M.; Kenyon, R.; Gutreuter, S.; Welke, K.I.; Thiel, P.A.

2001-01-01

Relocation of unionid mussels into refuges (e.g., hatchery ponds) has been suggested as a management tool to protect these animals from the threat of zebra mussel (Dreissena polymorpha) invasion. To evaluate the efficacy of relocation, we experimentally relocated 768 mussels, representing 5 species (Leptodea fragilis, Obliquaria reflexa, Fusconaia flava, Amblema plicata, and Quadrula quadrula) into an earthen pond at a National Fish Hatchery or back into the river. In both locations, mussels were placed into 1 of 4 treatments (mesh bags, corrals, and buried or suspended substrate-filled trays). Mussels were examined annually for survival, growth (shell length and wet mass), and physiological condition (glycogen concentration in foot and mantle and tissue condition index) for 36 mo in the pond or 40 mo in the river. We observed significant differences in mortality rates between locations (mortality was 4 times greater in the pond than in the river), among treatments (lowest mortality in the suspended trays), and among species (lower mortality in the amblemines than lamp-silines). Overall survival in both locations averaged 80% the 1st year; survival in the pond decreased dramatically after that. Although length and weight varied between locations and over time, these changes were small, suggesting that their utility as short-term measures of well being in long-lived unionids is questionable. Mussels relocated to the pond were in poor physiological condition relative to those in the river, but the magnitude of these differences was small compared to the inherent variability in physiological condition of reference mussels. These data suggest that relocation of unionids into artificial ponds is a high-risk conservation strategy; alternatives such as introduction of infected host fish, identification of mussel beds at greatest risk from zebra mussels, and a critical, large-scale assessment of the factors contributing to their decline should be explored.

Short-Period Surface Wave Based Seismic Event Relocation

Science.gov (United States)

White-Gaynor, A.; Cleveland, M.; Nyblade, A.; Kintner, J. A.; Homman, K.; Ammon, C. J.

2017-12-01

Accurate and precise seismic event locations are essential for a broad range of geophysical investigations. Superior location accuracy generally requires calibration with ground truth information, but superb relative location precision is often achievable independently. In explosion seismology, low-yield explosion monitoring relies on near-source observations, which results in a limited number of observations that challenges our ability to estimate any locations. Incorporating more distant observations means relying on data with lower signal-to-noise ratios. For small, shallow events, the short-period (roughly 1/2 to 8 s period) fundamental-mode and higher-mode Rayleigh waves (including Rg) are often the most stable and visible portion of the waveform at local distances. Cleveland and Ammon [2013] have shown that teleseismic surface waves are valuable observations for constructing precise, relative event relocations. We extend the teleseismic surface wave relocation method, and apply them to near-source distances using Rg observations from the Bighorn Arche Seismic Experiment (BASE) and the Earth Scope USArray Transportable Array (TA) seismic stations. Specifically, we present relocation results using short-period fundamental- and higher-mode Rayleigh waves (Rg) in a double-difference relative event relocation for 45 delay-fired mine blasts and 21 borehole chemical explosions. Our preliminary efforts are to explore the sensitivity of the short-period surface waves to local geologic structure, source depth, explosion magnitude (yield), and explosion characteristics (single-shot vs. distributed source, etc.). Our results show that Rg and the first few higher-mode Rayleigh wave observations can be used to constrain the relative locations of shallow low-yield events.

Post-accident fuel relocation and heat removal in the LMFBR

International Nuclear Information System (INIS)

Kazimi, M.S.; Tsai, S.S.; Gasser, R.D.

1976-08-01

Assessment of the dynamics of post-accident fuel relocation and heat removal is an important aspect of the evaluation of the consequences of a hypothetical accident in an LMFBR. Such an assessment is of particular importance in the evaluation of the post-accident radiological doses around the reactor site. In the present evaluation particular attention is given to the design features of the Clinch River Breeder Reactor Plant (CRBR). Fuel relocation and heat removal, assuming certain conditions have resulted in core disruption, are discussed. The discussion of events and phenomena involved in the relocation processes is centered around the resulting patterns of heat source distribution. The factors influencing fuel relocation and distribution in the inlet and outlet plena of the reactor vessel are discussed. The current technology of in-vessel heat removal is applied to the design of the CRBR reactor. Both fuel debris cooling limits and overall coolant flow in the reactor under natural convection conditions are explored. Some of the uncertainties in ex-vessel fuel behavior are addressed. In particular, the effect of melting the cavity bed on the rate of growth of a molten fuel pool is investigated

Understanding the Experiences of Relocatees During Forced Relocation in Chinese Urban Restructuring

NARCIS (Netherlands)

Li, X.; van Ham, M.; Kleinhans, R.J.

Despite the massive forced relocation of residents during urban restructuring in China, there are no systematic studies on how residents undergo the process. Most studies concerning urban restructuring in China directly equate forced relocation with displacement, which has a negative connotation.

The Prevalence of Job Stress and its Relationship with Burnout Syndrome among the Academic Members of Lorestan University of Medical Sciences.

Science.gov (United States)

Nazari, Hedayat; Jariani, Mojgan; Beiranvand, Shorangiz; Saki, Mandana; Aghajeri, Nasrin; Ebrahimzadeh, Farzad

2016-03-01

Burnout syndrome is one of the consequences and the results of occupational or job stress emerged in the form of emotional exhaustion feeling, depersonalization and decrement personal accomplishment. The aim of this study was to determine the occupational stress and its relationship with burnout syndrome in the academic members of Lorestan University of Medical Sciences. This descriptive cross-sectional survey was conducted on 111 of the faculty members via multistage sampling. Data were collected by the questionnaire of Maslach Burnout Inventory (MBI), and Osipow Occupational Stress Inventory (OSI- R). Data were analyzed by using descriptive statistics as well as analytical statistics such as chi square, Kruskal-Wallis, Mann Whitney tests and Pearson correlation coefficient. The results showed that the most of the participants had a low level of burnout three dimensions including emotional burnout (72.1%), depersonalization (81.1%), and the decrement of personal accomplishment (56.8%). Moreover 79.3% of samples had a low occupational stress, but there was a meaningful relationship between occupational stress and dimensions of burnout syndrome with an exception for the intensity of decrement of personal accomplishment. Academic members were in an appropriate condition concerning burnout syndrome and occupational stress. However by applying some strategies to decrease stress and determining stress resources, we can improve their psychological health of academic members.

The Prevalence of Job Stress and its Relationship with Burnout Syndrome among the Academic Members of Lorestan University of Medical Sciences

Science.gov (United States)

Nazari, Hedayat; Jariani, Mojgan; Beiranvand, Shorangiz; Saki, Mandana; Aghajeri, Nasrin; Ebrahimzadeh, Farzad

2016-01-01

Introduction: Burnout syndrome is one of the consequences and the results of occupational or job stress emerged in the form of emotional exhaustion feeling, depersonalization and decrement personal accomplishment. The aim of this study was to determine the occupational stress and its relationship with burnout syndrome in the academic members of Lorestan University of Medical Sciences. Methods: This descriptive cross-sectional survey was conducted on 111 of the faculty members via multistage sampling. Data were collected by the questionnaire of Maslach Burnout Inventory (MBI), and Osipow Occupational Stress Inventory (OSI- R). Data were analyzed by using descriptive statistics as well as analytical statistics such as chi square, Kruskal-Wallis, Mann Whitney tests and Pearson correlation coefficient. Results: The results showed that the most of the participants had a low level of burnout three dimensions including emotional burnout (72.1%), depersonalization (81.1%), and the decrement of personal accomplishment (56.8%). Moreover 79.3% of samples had a low occupational stress, but there was a meaningful relationship between occupational stress and dimensions of burnout syndrome with an exception for the intensity of decrement of personal accomplishment. Conclusion: Academic members were in an appropriate condition concerning burnout syndrome and occupational stress. However by applying some strategies to decrease stress and determining stress resources, we can improve their psychological health of academic members. PMID:26989668

The Prevalence of Job Stress and its Relationship with Burnout Syndrome among the Academic Members of Lorestan University of Medical Sciences

Directory of Open Access Journals (Sweden)

Hedayat Nazari

2016-03-01

Full Text Available Introduction: Burnout syndrome is one of the consequences and the results of occupational or job stress emerged in the form of emotional exhaustion feeling, depersonalization and decrement personal accomplishment. The aim of this study was to determine the occupational stress and its relationship with burnout syndrome in the academic members of Lorestan University of Medical Sciences. Methods: This descriptive cross-sectional survey was conducted on 111 of the faculty members via multistage sampling. Data were collected by the questionnaire of Maslach Burnout Inventory (MBI, and Osipow Occupational Stress Inventory (OSI- R. Data were analyzed by using descriptive statistics as well as analytical statistics such as chi square, Kruskal-Wallis, Mann Whitney tests and Pearson correlation coefficient. Results: The results showed that the most of the participants had a low level of burnout three dimensions including emotional burnout (72.1%, depersonalization (81.1%, and the decrement of personal accomplishment (56.8%. Moreover 79.3% of samples had a low occupational stress, but there was a meaningful relationship between occupational stress and dimensions of burnout syndrome with an exception for the intensity of decrement of personal accomplishment. Conclusion: Academic members were in an appropriate condition concerning burnout syndrome and occupational stress. However by applying some strategies to decrease stress and determining stress resources, we can improve their psychological health of academic members.

Nest enlargement in leaf-cutting ants: relocated brood and fungus trigger the excavation of new chambers.

Directory of Open Access Journals (Sweden)

Daniela Römer

Full Text Available During colony growth, leaf-cutting ants enlarge their nests by excavating tunnels and chambers housing their fungus gardens and brood. Workers are expected to excavate new nest chambers at locations across the soil profile that offer suitable environmental conditions for brood and fungus rearing. It is an open question whether new chambers are excavated in advance, or will emerge around brood or fungus initially relocated to a suitable site in a previously-excavated tunnel. In the laboratory, we investigated the mechanisms underlying the excavation of new nest chambers in the leaf-cutting ant Acromyrmex lundi. Specifically, we asked whether workers relocate brood and fungus to suitable nest locations, and to what extent the relocated items trigger the excavation of a nest chamber and influence its shape. When brood and fungus were exposed to unfavorable environmental conditions, either low temperatures or low humidity, both were relocated, but ants clearly preferred to relocate the brood first. Workers relocated fungus to places containing brood, demonstrating that subsequent fungus relocation spatially follows the brood deposition. In addition, more ants aggregated at sites containing brood. When presented with a choice between two otherwise identical digging sites, but one containing brood, ants' excavation activity was higher at this site, and the shape of the excavated cavity was more rounded and chamber-like. The presence of fungus also led to the excavation of rounder shapes, with higher excavation activity at the site that also contained brood. We argue that during colony growth, workers preferentially relocate brood to suitable locations along a tunnel, and that relocated brood spatially guides fungus relocation and leads to increased digging activity around them. We suggest that nest chambers are not excavated in advance, but emerge through a self-organized process resulting from the aggregation of workers and their density

Nest relocation and excavation in the Florida harvester ant, Pogonomyrmex badius.

Directory of Open Access Journals (Sweden)

Walter R Tschinkel

Full Text Available The Florida harvester ant (Pogonomyrmex badius excavates deep nests in the sandy soils of the Gulf and Atlantic coastal plains. Nest relocations of over 400 colonies in a north Florida coastal plains pine forest were tracked and mapped from 2010 to 2013. Individual colonies varied from one move in two years to four times a year, averaging about one per year. Almost all moves occurred between May and November peaking in July when more than 1% of the colonies moved per day. Move directions were random, and averaged 4 m, with few moves exceeding 10 m. Distance moved was not related to colony size. Over multiple moves, paths were random walks around the original nest location. Relocation is probably intrinsic to the life history of this species, and the causes of relocation remain obscure--the architecture of old and new nests was very similar, and neither the forest canopy nor the density or size of neighbors was correlated with relocation. Monitoring entire relocations (n = 20 showed that they were usually completed in 4 to 6 days. Moves were diurnal, peaking in the mornings and afternoons dipping during mid-day, and ceasing before sundown. Workers excavated the new nest continuously during the daytime throughout the move and beyond. A minority of workers carried seeds, charcoal and brood, with seeds being by far the most common burden. The proportion of burdened workers increased throughout the move. Measured from year to year, small colonies gained size and large ones lost it. Colonies moving more than once in two years lost more size than those moving less often, suggesting that moving may bear a fitness cost. Colony relocation is a dramatic and consistent feature of the life history of the Florida harvester ant, inviting inquiry into its proximal and ultimate causes.

Reexamining the Impact of Employee Relocation Assistance on Housing Prices

OpenAIRE

Marcus T. Allen; Ronald C. Rutherford; Thomas M. Springer

1997-01-01

In this paper, we reexamine the issue of whether corporate relocation assistance programs for transferred employees significantly affect sale prices of single-family homes. We estimate a hedonic price equation that includes physical housing characteristics, location factors, occupancy status, and type of seller for a sample of 2,441 transactions. Seller types include (a) transferred employees who were given direct relocation assistance, (b) transferred employees who were not given direct relo...

Technique for estimating relocated gap width for gap conductance calculations

International Nuclear Information System (INIS)

Klink, P.H.

1978-01-01

Thermally induced fuel fragmentation and relocation has been demonstrated to influence the thermal behavior of a fuel rod in two ways. The effective fuel pellet conductivity is decreased and pellet-to-cladding heat transfer is improved. This paper presents a correlation between as-built and relocated gap width which, used with the Ross and Stoute Gap Conductance Correlation and an appropriate fuel thermal expansion model, closely predicts the measured gap conductances

Adductor insertion avulsion syndrome with stress fracture of femoral shaft: MRI findings

International Nuclear Information System (INIS)

Lawande, M.A.; Sankhe, S.; Pungavkar, S.A.; Patkar, D.P.

2007-01-01

Full text: Chronic vague hip pain may be caused by stress-related injury in the proximal or mid-femoral diaphysis. This has been described as an entity called adductor insertion avulsion syndrome, or thigh splints. In the appropriate clinical setting, the radiologist interpreting the magnetic resonance imaging must be aware of this condition as its imaging findings are subtle. The diagnosis will help the clinician plan the appropriate management. Magnetic resonance imaging can also depict the complications such as stress fracture

Structural Model for the Effects of Perceived Indoor Work Environment on Sick Building Syndrome and Stress

Directory of Open Access Journals (Sweden)

Abdullah Nor Hazana

2016-01-01

Full Text Available Sick Building syndrome (SBS and stress have a prevalent influence on organizational productivity and competitiveness. Unhealthy employees not only tend to have high medical leaves but also low productivity due to ailments and discomforts. Studies that investigate the effects of indoor work environment on Sick Building Syndrome (SBS have yielded mixed results while their effect on stress has not been empirically established. Furthermore, studies that simultaneously investigate both SBS and stress are almost non-existent. Thus, this study aimed to study the effects of perceived indoor work environment on SBS and stress and the link between SBS and stress. A cross-sectional survey participated by 598 employees from various industries was conducted from September to October 2015. Data were analyzed using Partial Least Square Structural Equation Modeling (PLS-SEM to assess both the measurement model and the path structure. The results suggest that indoor work environment has significant yet the weak effect on SBS while it has no effect on stress. However, SBS has a strong significant relationship with stress. The implication of this study on the importance of conducive indoor work environment is discussed with suggestions for future studies.

Moving as a gift: relocation in older adulthood.

Science.gov (United States)

Perry, Tam E

2014-12-01

While discussions of accessibility, mobility and activities of daily living frame relocation studies, in older adulthood, the paper explores the emotional motivation of gift giving as a rationale for moving. This ethnographic study investigates the processes of household disbandment and decision-making of older adults in the Midwestern United States relocating in post-Global Financial Crisis contexts. In this study, relationships are created and sustained through the process of moving, linking older adults (n=81), their kin (n=49), and professionals (n=46) in the Midwestern United States. Using Marcel Mauss' The Gift (1925/1990) as a theoretical lens, relocation in older adulthood is conceptualized as a gift in two ways: to one's partner, and one's kin. Partners may consider gift-giving in terms of the act of moving to appease and honor their partner. Kin who were not moving themselves were also recipients of the gift of moving. These gifts enchain others in relationships of reciprocity. However these gifts, like all gifts, are not without costs or danger, so this paper examines some of the challenges that emerge along with gift-giving. Copyright © 2014 Elsevier Inc. All rights reserved.

Bartter/Gitelman syndromes as a model to study systemic oxidative stress in humans.

Science.gov (United States)

Maiolino, Giuseppe; Azzolini, Matteo; Rossi, Gian Paolo; Davis, Paul A; Calò, Lorenzo A

2015-11-01

Reactive oxygen species (ROS) are intermediates in reduction-oxidation reactions that begin with the addition of one electron to molecular oxygen, generating the primary ROS superoxide, which in turn interacts with other molecules to produce secondary ROS, such as hydrogen peroxide, hydroxyl radical, and peroxynitrite. ROS are continuously produced during metabolic processes and are deemed to play an important role in cardiovascular diseases, namely, myocardial hypertrophy and fibrosis and atherosclerosis, via oxidative damage of lipids, proteins, and deoxyribonucleic acid. Angiotensin II (Ang II) is a potent vasoactive agent that also exerts mitogenic, proinflammatory, and profibrotic effects through several signaling pathways, in part involving ROS, particularly superoxide and hydrogen peroxide. Moreover, Ang II stimulates NADPH oxidases, leading to higher ROS generation and oxidative stress. Bartter/Gitelman syndrome patients, despite elevated plasma renin activity, Ang II, and aldosterone levels, exhibit reduced peripheral resistance, normal/low blood pressure, and blunted pressor effect of vasoconstrictors. In addition, notwithstanding the activation of the renin-angiotensin system and the increased plasma levels of Ang II, these patients display decreased production of ROS, reduced oxidative stress, and increased antioxidant defenses. In fact, Bartter/Gitelman syndrome patients are characterized by reduced levels of p22(phox) gene expression and undetectable plasma peroxynitrite levels, while showing increased plasma antioxidant power and expression of antioxidant enzymes, such as heme oxygenase-1. In conclusion, multifarious data suggest that Bartter and Gitelman syndrome patients are a model of low oxidative stress and high antioxidant defenses. The contribution offered by the study of these syndromes in elucidating the molecular mechanisms underlying this favorable status could offer chances for new therapeutic targets in disease characterized by high

[Fatigue syndrome: Stress, Burnout and depression in Urology.

Science.gov (United States)

Rodríguez-Socarrás, Moisés; Vasquez, Juan Luis; Uvin, Pieter; Skjold-Kingo, Pernille; Gómez Rivas, Juan

2018-01-01

To determine the factors related to stress, Burnout and depression in urology, as well as consequences in residents and urologists, in addition to the possible applicable strategies to diminish and treat them. Depression, stress and Burnout syndrome has become a problem in urology specialty. These topics have gained interest in international congresses and urological associations. Efforts are being made to find related factors as well as possible strategies and applicable support programs. Burnout frequency is higher among health professionals than general population, 40-76% in students and residents, its incidence has skyrocketed in recent years, in addition Urology is one of the specialties with highest incidence and severity. Its increase has been related to work overload, documentation, administrative/bureaucratic workload, hostile work environment; its consequences include poor work performance, medical errors, depression, substance abuse, disruption in family and couple relationships and suicidal ideation. Strategies for prevention including resilience training, lifestyle balance, teamwork, and support programs. Stress, burnout and depression are problems in urology, early detection, promoting individual techniques in resilience, lifestyle and teamwork are fundamental now and for the future of the specialty. Developing and implementing support programs should be seriously considered by health systems and urological associations.

Analysis of core degradation and relocation phenomena and scenarios in a Nordic-type BWR

Energy Technology Data Exchange (ETDEWEB)

Galushin, Sergey, E-mail: galushin@kth.se; Kudinov, Pavel, E-mail: pkudinov@kth.se

2016-12-15

Highlights: • A data base of the debris properties in lower plenum generated using MELCOR code. • The timing of safety systems has significant effect on the relocated debris properties. • Loose coupling between core relocation and vessel failure analyses was established. - Abstract: Severe Accident Management (SAM) in Nordic Boiling Water Reactors (BWR) employs ex-vessel cooling of core melt debris. The melt is released from the failed vessel and poured into a deep pool of water located under the reactor. The melt is expected to fragment, quench, and form a debris bed, coolable by a natural circulation and evaporation of water. Success of the strategy is contingent upon melt release conditions from the vessel and melt-coolant interaction that determine (i) properties of the debris bed and its coolability (ii) potential for energetic melt-coolant interactions (steam explosions). Risk Oriented Accident Analysis Methodology (ROAAM+) framework is currently under development for quantification of the risks associated with formation of non-coolable debris bed and occurrence of steam explosions, both presenting a credible threats to containment integrity. The ROAAM+ framework consist of loosely coupled models that describe each stage of the accident progression. Core relocation analysis framework provides initial conditions for melt vessel interaction, vessel failure and melt release frameworks. The properties of relocated debris and melt release conditions, including in-vessel and ex-vessel pressure, lower drywell pool depth and temperature, are sensitive to the accident scenarios and timing of safety systems recovery and operator actions. This paper illustrates a methodological approach and relevant data for establishing a connection between core relocation and vessel failure analysis in ROAAM+ approach. MELCOR code is used for analysis of core degradation and relocation phenomena. Properties of relocated debris are obtained as functions of the accident scenario

78 FR 2319 - Relocation of Regulations

Science.gov (United States)

2013-01-11

...) operations; and Bank assistance for the Resolution Funding Corporation (RefCorp). This final rule relocates... Board Part 996/FHFA Part 1271--Subpart E (Authority for Bank Assistance of the Resolution Funding... National Mortgage Association and any affiliate thereof, and any Federal Home Loan Bank. Resolution Funding...

Aetiology, imaging and treatment of medial tibial stress syndrome

OpenAIRE

Moen, M.H.

2012-01-01

The work contained is this thesis discusses aetiology, imaging and treatment of a common leg injury: medial tibial stress syndrome (MTSS). Although a common injury, the number of scientific articles on this topic is relatively low as is explained in chapter 1. This chapter also highlights that the most probable cause of MTSS is bone overload and not traction induced periostitis. In chapter 2 a review of the literature on MTSS is provided until 2009. Chapters 3 and 4 discuss different common a...

Oxidative stress, mitochondrial abnormalities and antioxidant defense in Ataxia-telangiectasia, Bloom syndrome and Nijmegen breakage syndrome

Directory of Open Access Journals (Sweden)

Mateusz Maciejczyk

2017-04-01

Full Text Available Rare pleiotropic genetic disorders, Ataxia-telangiectasia (A-T, Bloom syndrome (BS and Nijmegen breakage syndrome (NBS are characterised by immunodeficiency, extreme radiosensitivity, higher cancer susceptibility, premature aging, neurodegeneration and insulin resistance. Some of these functional abnormalities can be explained by aberrant DNA damage response and chromosomal instability. It has been suggested that one possible common denominator of these conditions could be chronic oxidative stress caused by endogenous ROS overproduction and impairment of mitochondrial homeostasis. Recent studies indicate new, alternative sources of oxidative stress in A-T, BS and NBS cells, including NADPH oxidase 4 (NOX4, oxidised low-density lipoprotein (ox-LDL or Poly (ADP-ribose polymerases (PARP. Mitochondrial abnormalities such as changes in the ultrastructure and function of mitochondria, excess mROS production as well as mitochondrial damage have also been reported in A-T, BS and NBS cells. A-T, BS and NBS cells are inextricably linked to high levels of reactive oxygen species (ROS, and thereby, chronic oxidative stress may be a major phenotypic hallmark in these diseases. Due to the presence of mitochondrial disturbances, A-T, BS and NBS may be considered mitochondrial diseases. Excess activity of antioxidant enzymes and an insufficient amount of low molecular weight antioxidants indicate new pharmacological strategies for patients suffering from the aforementioned diseases. However, at the current stage of research we are unable to ascertain if antioxidants and free radical scavengers can improve the condition or prolong the survival time of A-T, BS and NBS patients. Therefore, it is necessary to conduct experimental studies in a human model.

EFFECTIVE WAYS TO MANAGE STRESS AND UNMASK THE ABILITIES OF PEOPLE WITH ASPERGER’S SYNDROME

OpenAIRE

Riichiro Ishida

2013-01-01

People with Asperger’s syndrome often have superior abilities in various fields, including art, natural science, and solving social problems. However, they tend to become stressed easily due to difficulties in relating to others. This stress sometimes prevents them from showing their full potential. Their abilities and tendency to become stressed are similar to those of people with schizoid temperament. Recent evidence has shown that purpose in life (PIL)/ikigai, moderate aerobic exercise, an...

Relocation of belt conveyors along the final slope of the Belacevac surface coal mine

Energy Technology Data Exchange (ETDEWEB)

Maksimovic, N; Rosic, Z

1987-07-01

Describes how following a landslide on the northern wing of the Belacevac surface coal mine the belt conveyor lines had to be relocated in order to assure a reliable coal supply to the Kosovo A and Kosovo B thermal power stations. The relocation was achieved in three phases with new approach cuts being made, necessitating the removal of 280,000 m/sup 3/ of overburden in the first phase and 870,000 m/sup 3/ in the second phase of the reconstruction. Illustrates the relocation of the conveyor system by means of site plans and notes that the production of coal and the removal of overburden were not interrupted during the relocation exercise. 2 refs.

[Association between occupational psychological stress and metabolic syndrome].

Science.gov (United States)

Liu, Herong; Song, Hui; Tian, Rulong; Chen, Lijun; Zhang, Wei; Qiang, Yan

2015-02-01

To investigate the association between occupational psychological stress and metabolic syndrome (MS) in Hui and Han populations in Ningxia, China. A 1:1 matched case-control study was performed. A total of 600 unrelated patients aged from 20 to 60 years who were clearly diagnosed with MS in General Hospital of Ningxia Medical University and Wuzhong People's Hospital from October 2011 to October 2012 were collected as the case group (MS group). A total of 600 healthy people who underwent a regular health examination in the same hospital during the same period were selected as the control group with matched gender, nationality, and age (≤ ± 3 years). The self-designed questionnaire was used to investigate the general situations and do the physical examination, and the fasting venous blood samples were collected for laboratory biochemical blood tests. The Occupational Stress Inventory (OSI) was used to investigate the subjects' occupational stress factors and stress levels. With the increase in stress levels, the levels of WC, FPG, TG, AST, and UA were increased, WHR, SBP, and DBP first increased and then decreased, and the level of HDL-C increased. There were statistically significant differences in these parameters between the two groups (P occupational psychological stress test results showed that the total score of stress factors (t = 6.676, P 0.05). There were no significant differences in the total score of stress factors and the score of each factor between Hui and Han groups (P>0.05). The relative risks of MS in the people with moderate stress exposure were 2.325 and 2.331 times those in the people with mild stress exposure before and after adjustment for age, gender, education level, marriage status, smoking, and drinking, and the relative risks for MS in the people with severe stress exposure were 3.000 and 3.126 times those in the people with mild stress exposure. There were significant differences in the detection rates of abdominal obesity, high TG

Burnout Syndrome of Teachers

OpenAIRE

Semrádová, Michaela

2013-01-01

The bachelor's thesis covers burnout syndrome of teachers. Defines burnout syndrome, describes its causes and symptoms. Describes teaching as helping profession and focousing on stressful situations at school. In the last chapter described different prevention strategies burnout syndrome. Key words: burnout syndrome, teaching, teacher, helping professions, beginning teacher, stress

Mechanisms of Stress-Induced Visceral Pain: Implications in Irritable Bowel Syndrome.

Science.gov (United States)

Greenwood-Van Meerveld, B; Moloney, R D; Johnson, A C; Vicario, M

2016-08-01

Visceral pain is a term describing pain originating from the internal organs of the body and is a common feature of many disorders, including irritable bowel syndrome (IBS). Stress is implicated in the development and exacerbation of many visceral pain disorders. Recent evidence suggests that stress and the gut microbiota can interact through complementary or opposing factors to influence visceral nociceptive behaviours. The Young Investigator Forum at the International Society of Psychoneuroendocrinology (ISPNE) annual meeting reported experimental evidence suggesting the gut microbiota can affect the stress response to affect visceral pain. Building upon human imaging data showing abnormalities in the central processing of visceral stimuli in patients with IBS and knowledge that the amygdala plays a pivotal role in facilitating the stress axis, the latest experimental evidence supporting amygdala-mediated mechanisms in stress-induced visceral pain was reviewed. The final part of the session at ISPNE reviewed experimental evidence suggesting that visceral pain in IBS may be a result, at least in part, of afferent nerve sensitisation following increases in epithelial permeability and mucosal immune activation. © 2016 British Society for Neuroendocrinology.

Performance Analysis of a Forecasting Relocation Model for One-Way Carsharing

Directory of Open Access Journals (Sweden)

Ganjar Alfian

2017-06-01

Full Text Available A carsharing service can be seen as a transport alternative between private and public transport that enables a group of people to share vehicles based at certain stations. The advanced carsharing service, one-way carsharing, enables customers to return the car to another station. However, one-way implementation generates an imbalanced distribution of cars in each station. Thus, this paper proposes forecasting relocation to solve car distribution imbalances for one-way carsharing services. A discrete event simulation model was developed to help evaluate the proposed model performance. A real case dataset was used to find the best simulation result. The results provide a clear insight into the impact of forecasting relocation on high system utilization and the reservation acceptance ratio compared to traditional relocation methods.

Cracking and relocation of UO2 fuel during nuclear operation

International Nuclear Information System (INIS)

Appelhans, A.D.; Dagbjartsson, S.J.

1981-01-01

Cracking and relocation of light water reactor (LWR) fuel pellets affect the axial gas flow path within nuclear reactor fuel rods and the thermal performance of the fuel. As part of the Nuclear Regulatory Commission's Water Reactor Safety Research Fuel Behavior Program, the Thermal Fuels Behavior Program of EG and G Idaho, Inc., is conducting fuel rod behavior studies in the Heavy Boiling Water Reactor in Halden, Norway. The Instrumental Fuel Assembly-430 (IFA-430) operated in that facility is a multipurpose assembly designed to provide information on fuel cracking and relocation, the long-term thermal response of LWR fuel rods subjected to various internal pressures and gas compositions, and the release of fission gases. This report presents the results of an analysis of fuel cracking and relocation phenomena as deduced from fuel rod axial gas flow and fuel temperature data from the first 6.5 GWd/tUO 2 burnup of the IFA-430

41 CFR 302-12.101 - May we enter into a contract with a relocation services company for the company to provide...

Science.gov (United States)

2010-07-01

... contract with a relocation services company for the company to provide relocation services? 302-12.101... the company to provide relocation services? Yes, you may enter into a contract with a relocation services company for the company to provide relocation services. ...

RelocaTE2: a high resolution transposable element insertion site mapping tool for population resequencing

Directory of Open Access Journals (Sweden)

Jinfeng Chen

2017-01-01

Full Text Available Background Transposable element (TE polymorphisms are important components of population genetic variation. The functional impacts of TEs in gene regulation and generating genetic diversity have been observed in multiple species, but the frequency and magnitude of TE variation is under appreciated. Inexpensive and deep sequencing technology has made it affordable to apply population genetic methods to whole genomes with methods that identify single nucleotide and insertion/deletion polymorphisms. However, identifying TE polymorphisms, particularly transposition events or non-reference insertion sites can be challenging due to the repetitive nature of these sequences, which hamper both the sensitivity and specificity of analysis tools. Methods We have developed the tool RelocaTE2 for identification of TE insertion sites at high sensitivity and specificity. RelocaTE2 searches for known TE sequences in whole genome sequencing reads from second generation sequencing platforms such as Illumina. These sequence reads are used as seeds to pinpoint chromosome locations where TEs have transposed. RelocaTE2 detects target site duplication (TSD of TE insertions allowing it to report TE polymorphism loci with single base pair precision. Results and Discussion The performance of RelocaTE2 is evaluated using both simulated and real sequence data. RelocaTE2 demonstrate high level of sensitivity and specificity, particularly when the sequence coverage is not shallow. In comparison to other tools tested, RelocaTE2 achieves the best balance between sensitivity and specificity. In particular, RelocaTE2 performs best in prediction of TSDs for TE insertions. Even in highly repetitive regions, such as those tested on rice chromosome 4, RelocaTE2 is able to report up to 95% of simulated TE insertions with less than 0.1% false positive rate using 10-fold genome coverage resequencing data. RelocaTE2 provides a robust solution to identify TE insertion sites and can be

41 CFR 302-2.3 - What determines my entitlements and allowances for relocation?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What determines my entitlements and allowances for relocation? 302-2.3 Section 302-2.3 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES INTRODUCTION 2-EMPLOYEES ELIGIBILITY REQUIREMENTS...

Medial tibial stress syndrome can be diagnosed reliably using history and physical examination

NARCIS (Netherlands)

Winters, M.; Bakker, E. W. P.; Moen, M. H.; Barten, C. C.; Teeuwen, R.; Weir, A.

2017-01-01

The majority of sporting injuries are clinically diagnosed using history and physical examination as the cornerstone. There are no studies supporting the reliability of making a clinical diagnosis of medial tibial stress syndrome (MTSS). Our aim was to assess if MTSS can be diagnosed reliably, using

EFFECTIVE WAYS TO MANAGE STRESS AND UNMASK THE ABILITIES OF PEOPLE WITH ASPERGER’S SYNDROME

Directory of Open Access Journals (Sweden)

Riichiro Ishida

2013-07-01

Full Text Available People with Asperger’s syndrome often have superior abilities in various fields, including art, natural science, and solving social problems. However, they tend to become stressed easily due to difficulties in relating to others. This stress sometimes prevents them from showing their full potential. Their abilities and tendency to become stressed are similar to those of people with schizoid temperament. Recent evidence has shown that purpose in life (PIL/ikigai, moderate aerobic exercise, and diet, which are related to each other and to prefrontal lobe function, are effective methods for coping with stress. PIL/ikigai, which is an attitude in which one seeks to establish meaning of life, is developed through positive experiences, such as cordial human relations with suitable role-models, spending time in beautiful natural surroundings, and being moved by people or events. PIL/ikigai for people without schizoid temperament develops through such positive experiences throughout their life. However, PIL/ikigai for people with schizoid temperament/Asperger’s syndrome develops through positive experiences during a limited number of life stages: infancy, childhood, and adulthood. Moderate aerobic exercise, such as walking, running, and swimming, were linked to finding food during the evolution of mankind. In turn, our diet supplies nutrients to our organs. Therefore, we propose that providing positive experiences during the critical periods and maturation periods of particular brain regions may influence PIL/ikigai, which is related to moderate aerobic exercise and diet. This process may help people with Asperger’s syndrome to demonstrate their full potential abilities and to contribute to various fields.

Intermittent hyperthyreosis. A heat stress syndrome

Energy Technology Data Exchange (ETDEWEB)

Sulman, F G; Tal, E; Pfeifer, Y; Superstine, E [Hebrew Univ., Jerusalem (Israel). Dept. of Applied Pharmacology

1975-09-01

Intermittent hyperthyreosis occurs under various forms of stress, especially heat stress. The clinician may diagnose such cases as masked or apathetic hyperthyroidism or 'forme fruste' hyperthyreosis or thyroid autonomy. As most routine and standard tests may here yield inconsistent results, it is the patients' anamnesis which may provide the clue. Our Bioclimatology Unit has now seen over 100 cases in which thyroid hypersensitivity towards heat was the most prominent syndrome: 10-15% of weather-sensitive patients are affected. The patients complain before or during heat spells of such contradictory symptoms as insomnia, irritability, tension, tachycardia, palpitations, precordial pain, dyspnoe, flushes with sweating or chills, tremor, abdominal pain or diarrhea, polyuria or pollakisuria, weight loss in spite of ravenous appetite, fatigue, exhaustion, depression, adynamia, lack of concentration and confusion. Determination of urinary neurohormones allows a differential diagnosis, intermittent hyperthyreosis being characterized by three cardinal symptoms: tachycardia - every case with more than 80 pulse beats being suspect (not specific); urinary histamine - every case excreting more than 90 ..mu..g/day being suspect. Again the drawback of this test is its lack of specificity, as histamine may also be increased in cases of allergy and spondylitis; urinary thyroxine - every case excreting more than 20 ..mu..g/day T-4 being suspect. This is the only specific test. Therapy should make use of lithium carbonate and betablockers. Propyl thiouracil is rarely required.

Study of seismicity around Toba area based on relocation hypocenter result from BMKG catalogue

Energy Technology Data Exchange (ETDEWEB)

Ramdhan, Mohamad [Indonesia' s Agency for Meteorology, Climatology and Geophysics (BMKG) Jl. Angkasa 1 No. 2 Kemayoran, Jakarta Pusat, 10720 (Indonesia); Nugraha, Andri Dian [Global Geophysics Research Group, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung, Indonesia, Jl. Ganesa 10, Bandung, 40132 (Indonesia)

2013-09-09

Toba area has complex tectonic setting attracting many earth scientists to study and understand tectonic and geological process or setting. The area is affected by oblique subduction zone, Renun Sumatran fault sub segment and some volcanoes that are near it. The earthquake catalogue provided by BMKG from April, 2009 to December, 2011 must be relocated firstly to get the precise hypocenter. We used catalogue data of P and S phase or P phase only and double-difference method to relocate the earthquakes. The results show hypocenter position enhancement that can be interpreted tectonically. The earthquakes after relocation relating to the Sumatran fault, subduction zone, volcanoes and seismic activities beneath Toba caldera can be mapped clearly. The relocated hypocenters in this study are very important to provide information for seismic hazard assessment and disaster mitigation study.

Multiple intra-hospital transports during relocation to a new critical care unit.

Science.gov (United States)

O'Leary, R-A; Conrick-Martin, I; O'Loughlin, C; Curran, M-R; Marsh, B

2017-11-01

Intra-hospital transport (IHT) of critically ill patients is associated with morbidity and mortality. Mass transfer of patients, as happens with unit relocation, is poorly described. We outline the process and adverse events associated with the relocation of a critical care unit. Extensive planning of the relocation targeted patient and equipment transfer, reduction in clinical pressure prior to the event and patient care during the relocation phase. The setting was a 30-bed, tertiary referral, combined medical and surgical critical care unit, located in a 570-bed hospital that serves as the national referral centre for cardiothoracic surgery and spinal injuries. All stakeholders relevant to the critical care unit relocation were involved, including nursing and medical staff, porters, information technology services, laboratory staff, project development managers, pharmacy staff and building contractors. Mortality at discharge from critical care unit and discharge from hospital were the main outcome measures. A wide range of adverse events were prospectively recorded, as were transfer times. Twenty-one patients underwent IHT, with a median transfer time of 10 min. Two transfers were complicated by equipment failure and three patients experienced an episode of hypotension requiring intervention. There were no cases of central venous or arterial catheter or endotracheal tube dislodgement, and hospital mortality at 30 days was 14%. Although IHT is associated with morbidity and mortality, careful logistical planning allows for efficient transfer with low complication rates.

The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.

Science.gov (United States)

Sukarieh, R; Sonenberg, N; Pelletier, J

2009-05-01

Stress granules (SGs) arise as a consequence of cellular stress, contain stalled translation preinitiation complexes, and are associated with cell survival during environmental insults. SGs are dynamic entities with proteins relocating into and out of them during stress. Among the repertoire of proteins present in SGs is eukaryotic initiation factor 4E (eIF4E), a translation factor required for cap-dependent translation and that regulates a rate-limiting step for protein synthesis. Herein, we demonstrate that localization of eIF4E to SGs is dependent on the presence of a family of repressor proteins, eIF4E-binding proteins (4E-BPs). Our results demonstrate that 4E-BPs regulate the SG localization of eIF4E.

41 CFR 302-3.508 - What relocation expenses are not authorized for new appointees or student trainees?

Science.gov (United States)

2010-07-01

... are not authorized for new appointees or student trainees? 302-3.508 Section 302-3.508 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION... relocation expenses are not authorized for new appointees or student trainees? You must not pay any expenses...

33 CFR 150.515 - What are the requirements for weight testing of newly installed or relocated craft?

Science.gov (United States)

2010-07-01

... weight testing of newly installed or relocated craft? 150.515 Section 150.515 Navigation and Navigable... testing of newly installed or relocated craft? (a) The operator must perform installation weight testing... (a) of this section, when survival crafts are relocated to another deepwater port. ...

Working Memory Impairments in Chromosome 22q11.2 Deletion Syndrome: The Roles of Anxiety and Stress Physiology

Science.gov (United States)

Sanders, Ashley F.; Hobbs, Diana A.; Stephenson, David D.; Laird, Robert D.; Beaton, Elliott A.

2017-01-01

Stress and anxiety have a negative impact on working memory systems by competing for executive resources and attention. Broad memory deficits, anxiety, and elevated stress have been reported in individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS). We investigated anxiety and physiological stress reactivity in relation to visuospatial…

Re-caching by Western scrub-jays (Aphelocoma californica cannot be attributed to stress.

Directory of Open Access Journals (Sweden)

James M Thom

Full Text Available Western scrub-jays (Aphelocoma californica live double lives, storing food for the future while raiding the stores of other birds. One tactic scrub-jays employ to protect stores is "re-caching"-relocating caches out of sight of would-be thieves. Recent computational modelling work suggests that re-caching might be mediated not by complex cognition, but by a combination of memory failure and stress. The "Stress Model" asserts that re-caching is a manifestation of a general drive to cache, rather than a desire to protect existing stores. Here, we present evidence strongly contradicting the central assumption of these models: that stress drives caching, irrespective of social context. In Experiment (i, we replicate the finding that scrub-jays preferentially relocate food they were watched hiding. In Experiment (ii we find no evidence that stress increases caching. In light of our results, we argue that the Stress Model cannot account for scrub-jay re-caching.

Performance Evaluation of Resilience using Service Relocation for GMPLS Networks

DEFF Research Database (Denmark)

Wessing, Henrik; Herrmann, Sven; Ruepp, Sarah Renée

2015-01-01

Cloud computing today represents an ever increasing part of the data exchanged over the Internet. This influences the core network, where the special properties of cloud based services can be leveraged to increase the network efficiency. This paper explores the concept of relocation for the backup...... path when providing resiliency to cloud services in the network. The control plane of a GMPLSenabled optical network is simulated, thus evaluating the proposed Path Computation Element architecture for service relocation. The results show that for increased offered traffic in the network, the overall...

Job Relocation is High in Chemical Industry.

Science.gov (United States)

Chemical and Engineering News, 1979

1979-01-01

The chances of an employee being relocated are higher in the chemical and plastics industries than in U.S. business as a whole. But the benefits provided by chemical and plastics companies to employees shifted to other locations are generally better than average. (Author/BB)

41 CFR 302-2.8 - When must I complete all aspects my relocation?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false When must I complete all aspects my relocation? 302-2.8 Section 302-2.8 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES INTRODUCTION 2-EMPLOYEES ELIGIBILITY REQUIREMENTS General Rules Time...

Modularization of Legacy Features by Relocation and Reconceptualization: How Much is Enough?

DEFF Research Database (Denmark)

Olszak, Andrzej; Jørgensen, Bo Nørregaard

2012-01-01

and reconceptualization of classes during a migration of the NDVis neuroscience application to the NetBeans module system. We do this by comparing the manually-modularized version of NDVis with three automatically-optimized designs that exhibit various degrees of relocation and reconceptualization. The obtained findings...... shed new light on the actual extent and impact of relocation and reconceptualization during modularization of legacy features....

Fuel relocation modeling in the SAS4A accident analysis code system

International Nuclear Information System (INIS)

Tentner, A.M.; Miles, K.J.

1985-01-01

SAS4A is a new code system which has been designed for analyzing the initial phase of Hypothetical Core Disruptive Accidents (HCDAs) up to gross melting or failure of the subassembly walls. During such postulated accident scenarios as the Loss-of-Flow (LOF) and Transient-Overpower (TOP) events, the relocation of the fuel plays a key role in determining the sequence of events and the amount of energy produced before neutronic shutdown. This paper discusses the general strategy used in modeling the various phenomena which lead to fuel relocation and presents the key fuel relocation models used in SAS4A. The implications of these models for the whole-core accident analysis as well as recent results of fuel motion experiment analyses are also presented

Comparative study of human mitochondrial proteome reveals extensive protein subcellular relocalization after gene duplications

Directory of Open Access Journals (Sweden)

Huang Yong

2009-11-01

Full Text Available Abstract Background Gene and genome duplication is the principle creative force in evolution. Recently, protein subcellular relocalization, or neolocalization was proposed as one of the mechanisms responsible for the retention of duplicated genes. This hypothesis received support from the analysis of yeast genomes, but has not been tested thoroughly on animal genomes. In order to evaluate the importance of subcellular relocalizations for retention of duplicated genes in animal genomes, we systematically analyzed nuclear encoded mitochondrial proteins in the human genome by reconstructing phylogenies of mitochondrial multigene families. Results The 456 human mitochondrial proteins selected for this study were clustered into 305 gene families including 92 multigene families. Among the multigene families, 59 (64% consisted of both mitochondrial and cytosolic (non-mitochondrial proteins (mt-cy families while the remaining 33 (36% were composed of mitochondrial proteins (mt-mt families. Phylogenetic analyses of mt-cy families revealed three different scenarios of their neolocalization following gene duplication: 1 relocalization from mitochondria to cytosol, 2 from cytosol to mitochondria and 3 multiple subcellular relocalizations. The neolocalizations were most commonly enabled by the gain or loss of N-terminal mitochondrial targeting signals. The majority of detected subcellular relocalization events occurred early in animal evolution, preceding the evolution of tetrapods. Mt-mt protein families showed a somewhat different pattern, where gene duplication occurred more evenly in time. However, for both types of protein families, most duplication events appear to roughly coincide with two rounds of genome duplications early in vertebrate evolution. Finally, we evaluated the effects of inaccurate and incomplete annotation of mitochondrial proteins and found that our conclusion of the importance of subcellular relocalization after gene duplication on

The Impact of Rapid Weight Loss on Oxidative Stress Markers and the Expression of the Metabolic Syndrome in Obese Individuals

Directory of Open Access Journals (Sweden)

Eva Tumova

2013-01-01

Full Text Available Objective. Obesity is linked with a state of increased oxidative stress, which plays an important role in the etiology of atherosclerosis and type 2 diabetes mellitus. The aim of our study was to evaluate the effect of rapid weight loss on oxidative stress markers in obese individuals with metabolic syndrome (MetS. Design and Methods. We measured oxidative stress markers in 40 obese subjects with metabolic syndrome (MetS+, 40 obese subjects without metabolic syndrome (MetS−, and 20 lean controls (LC at baseline and after three months of very low caloric diet. Results. Oxidized low density lipoprotein (ox-LDL levels decreased by 12% in MetS+ subjects, associated with a reduction in total cholesterol (TC, even after adjustment for age and sex. Lipoprotein associated phospholipase A2 (Lp-PLA2 activity decreased by 4.7% in MetS+ subjects, associated with a drop in LDL-cholesterol (LDL-C, TC, and insulin levels. Multivariate logistic regression analysis showed that a model including ox-LDL, LpPLA2 activity, and myeloperoxidase (MPO improved prediction of MetS status among obese individuals compared to each oxidative stress marker alone. Conclusions. Oxidative stress markers were predictive of MetS in obese subjects, suggesting a higher oxidative stress. Rapid weight loss resulted in a decline in oxidative stress markers, especially in MetS+ patients.

[Emotional stress-induced Shanghuo syndrome increases disease susceptibility].

Science.gov (United States)

Zhu, Si-Rui; Luo, Xiang; Li, Yi-Fang; Hiroshi, Kurihara; He, Rong-Rong

2018-04-01

Shanghuo(excessive internal heat) is a special organic state based on the concept of traditional Chinese medicine(TCM), commonly known as the abnormal heating syndrome of body in folks. With the acceleration of modern life rhythm and the increase of the social competition pressure, emotional stress has become an important cause for the spread of Shanghuo symptoms. What's more, Shanghuo can impact the body physiological functions to cause the onset, recurrence and progression of common diseases, harming the health of the body. According to the long-term research findings, the author found that Shanghuo referred to the imbalance of multiple physiological functions, such as nerve, immunity and metabolism, caused by emotional stress. "Shanghuo" is not a disease itself, but it can increase the susceptibility to a variety of diseases. This study reviewed the traditional medicine theory and the modern medical studies, and explored the relevance and correlation mechanisms between the Shanghuo symptoms and disease susceptibility, so as to provide a reference to improve the state of sub-health and prevent or treat modern diseases. Copyright© by the Chinese Pharmaceutical Association.

Microtubule-dependent relocation of branchial V-H+-ATPase to the basolateral membrane in the Pacific spiny dogfish (Squalus acanthias): a role in base secretion.

Science.gov (United States)

Tresguerres, Martin; Parks, Scott K; Katoh, Fumi; Goss, Greg G

2006-02-01

We have previously shown that continuous intravenous infusion of NaHCO3 for 24 h ( approximately 1000 micromol kg(-1) h(-1)) results in the relocation of V-H+-ATPase from the cytoplasm to the basolateral membrane in the gills of the Pacific dogfish. To further investigate this putative base-secretive process we performed similar experiments with the addition of colchicine, an inhibitor of cytoskeleton-dependent cellular trafficking processes. Blood pH and plasma total CO2 were significantly higher in the colchicines-treated, HCO3- -infused fish compared with fish infused with HCO3- alone. The effect of colchicine was highest after 24 h of infusion (8.33+/-0.06 vs 8.02+/-0.03 pH units, 15.72+/-3.29 vs 6.74+/-1.34 mmol CO2 l(-1), N=5). Immunohistochemistry and western blotting confirmed that colchicine blocked the transit of V-H+-ATPase to the basolateral membrane. Furthermore, western blotting analyses from whole gill and cell membrane samples suggest that the short-term (6 h) response to alkaline stress consists of relocation of V-H+-ATPases already present in the cell to the basolateral membrane, while in the longer term (24 h) there is both relocation of preexistent enzyme and upregulation in the synthesis of new units. Our results strongly suggest that cellular relocation of V-H+-ATPase is necessary for enhanced HCO3- secretion across the gills of the Pacific dogfish.

Relationship between irritable bowel syndrome, worry and stress in adolescent girls.

Science.gov (United States)

Song, Sang-Wook; Park, Seo-Jin; Kim, Se-Hong; Kang, Sung-Goo

2012-11-01

The aim of this study is to investigate prevalence of irritable bowel syndrome (IBS) among adolescents and difference in worry and stress between normal and IBS groups. Questionnaire survey was conducted at a girl's middle and high school. Students from seventh to eleventh grade participated in the examination on Rome II criteria, lifestyle and dietary habits. Worry and stress were measured with the Korean version Penn State Worry Questionnaire-Children and the Korean version Brief Encounter Psychosocial Instrument. Worry score was significantly higher in the IBS group (22.07 ± 9.38, P high school students than in middle school students (P = 0.02). Stress score also was higher in the IBS group than in the normal group (P high school girls than in the middle school ones (P = 0.04). Of all the lifestyle factors influencing IBS preference for fatty foods, preference for salty foods, drinking alcohol and sleeping for less than six hours a day were found to be significant. Worry and stress seem to be associated with IBS symptoms. The findings of this study draw a clue that less worry and stress will help decrease IBS symptoms.

An Updated Earthquake Relocation Catalog for the Island of Hawaíi from 2009 to 2016

Science.gov (United States)

Lin, G.; Okubo, P.; Shearer, P. M.; Matoza, R. S.

2017-12-01

We present an updated catalog of Hawaiian seismicity, systematically relocated from a starting catalog compiled by the Hawaiian Volcano Observatory (HVO). This is a continuation of our collaboration that began with relocating Hawaiian seismicity from 1992 through April 2009 and subsequently added 1986 through 1991, all initially processed with HVO's Caltech-USGS Seismic Processing systems. Our current efforts are initially focused on extending waveform cross-correlation analyses to significantly greater numbers of candidate event pairs of earthquakes recorded since 2009, after HVO migrated to its ANSS Quake Management Software (AQMS) systems. In its roughly 8 years of AQMS processing, HVO has cataloged over 170,000 events. Particular challenges with this more recent dataset relate to field network upgrades that introduced numerous broadband sensors to replace short-period instruments and significantly increased numbers of event triggers. A relatively low percentage of interactively-reviewed events compared to the pre-2009 catalogs also presents a significant challenge to our analysis. We start by ray tracing through a previously developed three-dimensional (3-D) seismic velocity model to relocate all the earthquakes with phase arrivals. We then use these 3-D relocated events, with improved absolute locations, as reference events to perform similar-event cluster analysis and differential-time relative relocation to all the available events in the data set. The resulting catalog of relocated, well-constrained hypocenters is an extension of our previous studies. Combined with earlier products of our systematic catalog relocations, the increased numbers of relocated earthquakes from more than 30 years of seismic monitoring offer enhanced opportunities for study and interpretation of seismic and volcanic processes spanning the entire 1986-2016 interval.

The Place of Stress and Emotions in the Irritable Bowel Syndrome.

Science.gov (United States)

Pellissier, S; Bonaz, B

2017-01-01

Our emotional state can have many consequences on our somatic health and well-being. Negative emotions such as anxiety play a major role in gut functioning due to the bidirectional communications between gut and brain, namely, the brain-gut axis. The irritable bowel syndrome (IBS), characterized by an unusual visceral hypersensitivity, is the most common disorder encountered by gastroenterologists. Among the main symptoms, the presence of current or recurrent abdominal pain or discomfort associated with bloating and altered bowel habits characterizes this syndrome that could strongly alter the quality of life. This chapter will present the physiopathology of IBS and explain how stress influences gastrointestinal functions (permeability, motility, microbiota, sensitivity, secretion) and how it could be predominantly involved in IBS. This chapter will also describe the role of the autonomic nervous system and the hypothalamic-pituitary axis through vagal tone and cortisol homeostasis. An analysis is made about how emotions and feelings are involved in the disruption of homeostasis, and we will see to what extent the balance between vagal tone and cortisol may reflect dysfunctions of the brain-gut homeostasis. Finally, the interest of therapeutic treatments focused on stress reduction and vagal tone enforcement is discussed. © 2017 Elsevier Inc. All rights reserved.

Oxidative Stress and Metabolic Syndrome: Cause or Consequence of Alzheimer's Disease?

Directory of Open Access Journals (Sweden)

Diana Luque-Contreras

2014-01-01

Full Text Available Alzheimer’s disease (AD is a major neurodegenerative disease affecting the elderly. Clinically, it is characterized by a progressive loss of memory and cognitive function. Neuropathologically, it is characterized by the presence of extracellular β-amyloid (Aβ deposited as neuritic plaques (NP and neurofibrillary tangles (NFT made of abnormal and hyperphosphorylated tau protein. These lesions are capable of generating the neuronal damage that leads to cell death and cognitive failure through the generation of reactive oxygen species (ROS. Evidence indicates the critical role of Aβ metabolism in prompting the oxidative stress observed in AD patients. However, it has also been proposed that oxidative damage precedes the onset of clinical and pathological AD symptoms, including amyloid-β deposition, neurofibrillary tangle formation, vascular malfunction, metabolic syndrome, and cognitive decline. This paper provides a brief description of the three main proteins associated with the development of the disease (Aβ, tau, and ApoE and describes their role in the generation of oxidative stress. Finally, we describe the mitochondrial alterations that are generated by Aβ and examine the relationship of vascular damage which is a potential prognostic tool of metabolic syndrome. In addition, new therapeutic approaches targeting ROS sources and metabolic support were reported.

The managerial issues related to transferring shop floor knowledge in manufacturing relocation

DEFF Research Database (Denmark)

Knudsen, Mette Præst; Madsen, Erik Skov

2014-01-01

Purpose – The purpose of this paper is to explore the specific practices of management in the dispatching unit and to identify mechanisms for supporting transfer of shop floor knowledge embedded in operating manufacturing equipment. Design/methodology/approach – The paper applies an inductive...... and a case study approach for exploring three empirical cases that represent different manufacturing facility relocation processes and differences in the applied managerial practices. Findings – The paper identifies two important gaps in international production literature when firms relocate equipment...... to other sites; a time gap (from dismantling to re-assembly of production facilities) and a space gap (from the current to the new site abroad). These gaps are important for understanding why relocation processes are difficult and what management can do to facilitate such processes. Practical implications...

41 CFR 302-3.2 - As a new appointee or student trainee what relocation expenses may my agency pay or reimburse me...

Science.gov (United States)

2010-07-01

... student trainee what relocation expenses may my agency pay or reimburse me for incident to a permanent... Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE New Appointee § 302-3.2 As a new appointee or student trainee what relocation...

Habitat use and home range traits of resident and relocated hares (Lepus europaeus, Pallas

Directory of Open Access Journals (Sweden)

Marco Bagliacca

2010-09-01

Full Text Available The aim of the study was to know the habitat preferences and home range of resident and relocated brown hares during the no hunting period. The trial was carried out in a protected area (PA and in a free hunting territory (FHT, both located in Florence province. During captures 21 hares were equipped with a necklace radio tag: 7 hares, resident group, were released in the same area of capture and 14 hares, relocated group, were relocated in six different locations within the FHT. The effect of place of release was analyzed by ANOVA and/or non parametric methods. Results showed that the home ranges of the resident group were characterised by a greater presence of fallow land and shrub land than relocated group (P< 0.05. Home range sizes and Max distances from the releasing sites differed between the two groups. Resident hares preferred landscape characterized by a higher density of patches than the relocated hares (152 vs. 70 n/100ha, 43 vs. 12 n/100ha, 4703 vs. 8142 sq.m respectively; P<0.01. The landscape structure indexes, the home range sizes and the maximum distance from the releasing sites suggest that the relocated hares even if released in suited habitats, will move from their releasing point to look for better habitats. Landscape with most complexity are preferred from the resident hare, and this result should be consider when a project to reintroduction of this lagomorph in a territory is programmed, or when it is necessary to improve the dynamic of a natural population.

Using an ecological ethics framework to make decisions about the relocation of wildlife.

Science.gov (United States)

McCoy, Earl D; Berry, Kristin

2008-12-01

Relocation is an increasingly prominent conservation tool for a variety of wildlife, but the technique also is controversial, even among conservation practitioners. An organized framework for addressing the moral dilemmas often accompanying conservation actions such as relocation has been lacking. Ecological ethics may provide such a framework and appears to be an important step forward in aiding ecological researchers and biodiversity managers to make difficult moral choices. A specific application of this framework can make the reasoning process more transparent and give more emphasis to the strong sentiments about non-human organisms held by many potential users. Providing an example of the application of the framework may also increase the appeal of the reasoning process to ecological researchers and biodiversity managers. Relocation as a conservation action can be accompanied by a variety of moral dilemmas that reflect the interconnection of values, ethical positions, and conservation decisions. A model that is designed to address moral dilemmas arising from relocation of humans provides/demonstrates/illustrates a possible way to apply the ecological ethics framework and to involve practicing conservationists in the overall decision-making process.

Stress reactivity in childhood functional abdominal pain or irritable bowel syndrome.

Science.gov (United States)

Gulewitsch, M D; Weimer, K; Enck, P; Schwille-Kiuntke, J; Hautzinger, M; Schlarb, A A

2017-01-01

Frequent abdominal pain (AP) in childhood has been shown to be associated with elevated experience of stress and with deficits in stress coping, but psychophysiological stress reactivity has been studied rarely. We examined whether children with frequent AP show altered reactions of the parasympathetic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis during and following an afternoon laboratory social stress task in comparison to healthy children and children with anxiety disorders. Twenty-four children with frequent AP (18 with functional AP and six with irritable bowel syndrome; M = 9.9 years), and 24 healthy controls underwent stressful free speech and arithmetic tasks. Twelve children with anxiety disorders served as second comparison sample. Groups were compared regarding parasympathetic reaction and saliva cortisol concentration. We found no differences in parasympathetic withdrawal between the groups. Concerning the HPA axis, we detected an attenuated cortisol reactivity in children with AP compared to both other groups. This study provides preliminary evidence that childhood AP is not associated with altered parasympathetic withdrawal during stress. It seems to be related to a down-regulated reactivity of the HPA axis. This pattern was ascertained in comparison to healthy children and also in comparison to children with anxiety disorders. Childhood abdominal pain could be related to down-regulated HPA axis reactivity to stress but not to altered parasympathetic reaction. Children with abdominal pain and children with anxiety disorders exhibit a divergent stress-related HPA axis reaction. © 2016 European Pain Federation - EFIC®.

Solving the Problem of Relocation of Residents from Old and Unfit Housing Stock

Directory of Open Access Journals (Sweden)

Prokopovich Vladimir Pavlovich

2014-06-01

Full Text Available The speed of construction does not solve the problem of relocating the residents from old and unfit housing stock, the number of which exceeds the maximum permissible values. To assess housing stock condition, the author uses a model describing the path traversed by an accelerated body. The graphic analogue of model is a coil spring with a variable, increasing step, from which it follows that the volume of old and unfit housing stock is growing exponentially. The proposed model helps to project possible consequences of slow relocation, to plan necessary annual volume of new construction for relocation of the residents, as well as to assess the additional resources for preventing accidents.

Coverage improvement in clustered wireless sensor networks by relocating mobile nodes based on waypoints

DEFF Research Database (Denmark)

Mathur, Prateek; Nielsen, Rasmus Hjorth; Prasad, Neeli R.

2013-01-01

by clusters with relocation of mobile nodes between the clusters. Mobile nodes are guided by waypoints between source and destination clusters without use of localization services. The simulation results have been presented which state the effectiveness of the proposed approach. Mobile node relocation has...

Thermal behavior of molten corium during TMI-2 core relocation event

International Nuclear Information System (INIS)

Anderson, J.L.; Sienicki, J.J.

1988-01-01

During the TMI-2 accident, a pool of molten corium formed in the central region of the core and was contained by solidified crusts. Failure of the crust surrounding the molten material, at approximately 224 min, resulted in a relocation of an estimated 20-25 tons of molten corium through peripheral fuel assemblies in the east side of the vessel, as well as through the core barrel assembly (CBA) at the periphery of the core. This paper presents the results of an analyses carried out to investigate the thermal interactions of molten corium with the CBA structures during the relocation event. The principal objectives of the analyses are: (a) to assess the potential for relocation to take place through the CBA versus the flow of molten core material directly downward through the core via the fuel assemblies; and (b) to understand the distribution of prior molten corium observed during vessel defueling examinations. 5 refs., 1 fig

Optimal timing for managed relocation of species faced with climate change

Science.gov (United States)

McDonald Madden, Eve; Runge, Michael C.; Possingham, Hugh P.; Martin, Tara G.

2011-01-01

Managed relocation is a controversial climate-adaptation strategy to combat negative climate change impacts on biodiversity. While the scientific community debates the merits of managed relocation1,2,3,4,5,6,7,8,9,10,11,12, species are already being moved to new areas predicted to be more suitable under climate change13,14. To inform these moves, we construct a quantitative decision framework to evaluate the timing of relocation in the face of climate change. We find that the optimal timing depends on many factors, including the size of the population, the demographic costs of translocation and the expected carrying capacities over time in the source and destination habitats. In some settings, such as when a small population would benefit from time to grow before risking translocation losses, haste is ill advised. We also find that active adaptive management15,16 is valuable when the effect of climate change on source habitat is uncertain, and leads to delayed movement.

The Consequences of State Intervention: Forced Relocations and Sámi Rights in Sweden, 1919–2012

Directory of Open Access Journals (Sweden)

Patrik Lantto

2014-08-01

Full Text Available From the late 19th century up until the post-war period, Swedish Sámi policy was dominated by an image of the Sámi as nomadic reindeer herders. As nomads, the Sámi connection to the land they used was generally considered weaker than that of the settled population, and forced relocations were part of the Sámi policy for several decades as a solution to international developments that affected reindeer husbandry. These relocations have had and still have an effect on reindeer husbandry in Sweden today. The article examines and analyses forced relocations of Sámi reindeer herders, and specifically the effects of these relocations on the situation in one Reindeer Herding District: Vapsten. Strong intra-Sámi conflicts in the district today have historical roots in the forced relocations to the area, and the article analyses these and the role of the state both in causing the conflicts as well as solving them.

Prevalence of Burnout Syndrome in patients admitted with acute coronary syndrome.

Science.gov (United States)

Prosdócimo, Ana Cláudia Giaxa; Lucina, Luciane Boreki; Marcia, Olandoski; Jobs, Priscila Megda João; Schio, Nicolle Amboni; Baldanzi, Fernanda Fachin; Costantini, Costantino Ortiz; Benevides-Pereira, Ana Maria Teresa; Guarita-Souza, Luiz Cesar; Faria-Neto, José Rocha

2015-03-01

Burnout Syndrome is the extreme emotional response to chronic occupational stress, manifesting as physical and mental exhaustion. Although associated with higher prevalence of cardiovascular risk factors, no study so far has evaluated whether the Burnout Syndrome could be a prevalent factor in non-elderly individuals active in the labor market, admitted for acute coronary syndrome (ACS). To evaluate the prevalence of the Burnout Syndrome in non-elderly, economically active patients, hospitalized with ACS. Cross-sectional study conducted in a tertiary and private cardiology center, with economically active patients aged Burnout Syndrome was evaluated with the Burnout Syndrome Inventory (BSI), which assesses workplace conditions and four dimensions that characterize the syndrome: emotional exhaustion (EE), emotional distancing (EmD), dehumanization (De) and professional fulfillment (PF). The Lipp's Stress Symptoms Inventory for Adults (LSSI) was applied to evaluate global stress. Of 830 patients evaluated with suspected ACS, 170 met the study criteria, 90% of which were men, overall average age was 52 years, and 40.5% had an average income above 11 minimum wages. The prevalence of the Burnout Syndrome was 4.1%. When we evaluated each dimension individually, we found high EE in 34.7%, high De in 52.4%, high EDi in 30.6%, and low PF in 5.9%. The overall prevalence of stress was 87.5%. We found a low prevalence of Burnout Syndrome in an economically active, non-elderly population among patients admitted for ACS in a tertiary and private hospital.

Records About Japanese Americans Relocated During World War II

Data.gov (United States)

National Archives and Records Administration — This series contains personal descriptive data about Japanese Americans evacuated from the states of Washington, Oregon, and California to ten relocation centers...

Transferring Knowledge in the Relocation of Manufacturing Units

DEFF Research Database (Denmark)

Yang, Cheng; Madsen, Erik; Liangsiri, Jirapha

2010-01-01

ABSTRACT Purpose--The global spread of production makes companies relocating their manufacturing units frequently. Not only equipments, systems and facilities, need to be moved, but the transfer of operational knowledge and experience seem to be a major challenge. However, discussions on knowledge...... transfer are derived predominantly from a cognitive perspective and normally focus on the organizational level. Thus, from the perspective of operations management, this paper aims to explore how to transfer production know-how on the shop floor level when manufacturing units are relocated and the paper...... indicate which means can be used to support this intra-firm transfer process. Design/methodology/approach--Four cases are identified from two action research projects on the basis of observations over one-and-half years and semi-structured interviews with more than 59 people. Other methods, such as surveys...

76 FR 32340 - Federal Travel Regulation; Temporary Duty (TDY) Travel Allowances (Taxes); Relocation Allowances...

Science.gov (United States)

2011-06-06

... reflection of the actual tax impact on the employee. Therefore, this proposed rule offers the one-year RITA... to estimate the additional income tax liability that you incur as a result of relocation benefits and... Allowances (Taxes); Relocation Allowances (Taxes) AGENCY: Office of Governmentwide Policy (OGP), General...

47 CFR 101.82 - Reimbursement and relocation expenses in the 2110-2150 MHz and 2160-2200 MHz bands.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Reimbursement and relocation expenses in the... License Transfers, Modifications, Conditions and Forfeitures § 101.82 Reimbursement and relocation expenses in the 2110-2150 MHz and 2160-2200 MHz bands. (a) Reimbursement and relocation expenses for the...

Environmental Assessment for the vacuum process laboratory (VPL) relocation at the Lawrence Livermore National Laboratory

International Nuclear Information System (INIS)

1992-04-01

This Environmental Assessment (EA) evaluates the potential environmental impacts of relocating a vacuum process laboratory (VPL) from Building 321 to Building 2231 at Lawrence Livermore National Laboratory (LLNL). The VPL provides the latest technology in the field of vacuum deposition of coatings onto various substrates for several weapons-related and energy-related programs at LLNL. Operations within the VPL at LLNL will not be expanded nor reduced by the relocation. No significant environmental impacts are expected as a result of the relocation of the VPL

Hyperbaric Oxygen Therapy in the Treatment of Chronic Mild-Moderate Blast-Induced Traumatic Brain Injury Post-Concussion Syndrome (PCS) and Post Traumatic Stress Disorder (PTSD)

Science.gov (United States)

2017-10-01

Post-Concussion Syndrome (PCS) and Post Traumatic Stress Disorder (PTSD) PRINCIPAL INVESTIGATOR: Paul G. Harch, M.D. CONTRACTING ORGANIZATION...Traumatic Brain Injury Post-Concussion Syndrome (PCS) and Post Traumatic Stress Disorder (PTSD) 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR...injury (TBI) and post-traumatic stress disorder (PTSD) affect 11-28% and 13-17%, respectively, of U.S. combat troops returning from Iraq and

The impact of a stress induction task on tic frequencies in youth with Tourette Syndrome.

Science.gov (United States)

Conelea, Christine A; Woods, Douglas W; Brandt, Bryan C

2011-08-01

Tourette Syndrome (TS) is a neuropsychiatric disorder characterized by motor and vocal tics. Tic fluctuations are common and thought to be attributable in part, to contextual variables. Stress is one such variable, but its effects and mechanism of action are poorly understood. The current study measured the effects of a stress induction task on tic frequencies during periods of suppression and non-suppression of tics. Ten youth with TS between the ages of 9 and 17 were exposed to four conditions in random sequence: free-to-tic baseline (BL), reinforced tic suppression (SUP), reinforced tic suppression plus a stress induction task (SUP + STRESS), and a stress induction task alone (STRESS). Tic frequencies did not differ during STRESS and BL. Tic frequencies were greater in SUP + STRESS than SUP. Stress may impact tics through disrupting suppression efforts. Clinically, results suggest that interventions designed to improve tic inhibition in the presence of acute stressors may be beneficial. Copyright © 2011 Elsevier Ltd. All rights reserved.

Psychosocial Stress Predicts Future Symptom Severities in Children and Adolescents with Tourette Syndrome and/or Obsessive-Compulsive Disorder

Science.gov (United States)

Lin, Haiqun; Katsovich, Liliya; Ghebremichael, Musie; Findley, Diane B.; Grantz, Heidi; Lombroso, Paul J.; King, Robert A.; Zhang, Heping; Leckman, James F.

2007-01-01

Background: The goals of this prospective longitudinal study were to monitor levels of psychosocial stress in children and adolescents with Tourette syndrome (TS) and/or obsessive-compulsive disorder (OCD) compared to healthy control subjects and to examine the relationship between measures of psychosocial stress and fluctuations in tic,…

Cognitive coping strategies and stress in parents of children with Down syndrome: a prospective study

NARCIS (Netherlands)

van der Veek, Shelley M. C.; Kraaij, Vivian; Garnefski, Nadia

2009-01-01

The purpose of this study was to explore the cross-sectional and prospective relationships between cognitive coping strategies and parental stress in parents of children with Down syndrome. A total of 621 participants filled out questionnaires, including the Cognitive Emotion Regulation

Work Stress, Premenstrual Syndrome and Dysphoric Disorder: Are There Any Associations?

OpenAIRE

Namavar Jahromi, B; Pakmehr, S; Hagh-Shenas, H

2011-01-01

Background Women with recurrent and severe symptoms are diagnosed as having premenstrual syndrome (PMS), and if they suffer from severe affective symptoms, a diagnosis of premenstrual dysphoric disorder (PMDD) is made. The purpose of this study was to determine the association of work stress with PMS and PMDD. Methods Fifty-five female medical students in their internship program (ten 24-hour shifts per month) and 38 third-year female medical students without any shift duties were asked to pa...

On the dynamic of franchise (re)location in the North-American sport leagues

OpenAIRE

Narme, Thibaut

2013-01-01

As the cost of tax-dollar paid stadia rises and the talks of relocations in the main North-American pro leagues increase, a multi-field analysis on the different mechanisms that decides team relocation seems necessary. This paper reviews the different mechanisms participating team location and finally offer a new angle of analysis on the actual equilibrium and demonstrates its dynamic nature.

Mitochondrial translocation of Nur77 induced by ROS contributed to cardiomyocyte apoptosis in metabolic syndrome

Energy Technology Data Exchange (ETDEWEB)

Xu, Aibin; Liu, Jingyi [Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an (China); Institute of Cardiovascular Disease, General Hospital of Beijing Command, PLA, Beijing (China); Liu, Peilin; Jia, Min; Wang, Han [Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an (China); Tao, Ling, E-mail: lingtao2006@gmail.com [Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an (China)

2014-04-18

Highlights: • Metabolic syndrome exacerbated MI/R induced injury accompanied by decreased Nur77. • ROS led to Nur77 translocation in metabolic syndrome. • Inhibiting relocation of Nur77 to mitochondria reduced ROS-induced cardiomyocyte injury in metabolic syndrome. - Abstract: Metabolic syndrome is a major risk factor for cardiovascular diseases, and increased cardiomyocyte apoptosis which contributes to cardiac dysfunction after myocardial ischemia/reperfusion (MI/R) injury. Nur77, a nuclear orphan receptor, is involved in such various cellular events as apoptosis, proliferation, and glucose and lipid metabolism in several cell types. Apoptosis is positively correlated with mitochondrial translocation of Nur77 in the cancer cells. However, the roles of Nur77 on cardiac myocytes in patients with metabolic syndrome remain unclear. The objective of this study was to determine whether Nur77 may contribute to cardiac apoptosis in patients with metabolic syndrome after I/R injury, and, if so, to identify the underlying molecular mechanisms responsible. We used leptin-deficient (ob/ob) mice to make metabolic syndrome models. In this report, we observed that, accompanied by the substantial decline in apoptosis inducer Nur77, MI/R induced cardiac dysfunction was manifested as cardiomyopathy and increased ROS. Using the neonatal rat cardiac myocytes cultured in a high-glucose and high-fat medium, we found that excessive H{sub 2}O{sub 2} led to the significant alteration in mitochondrial membrane potential and translocation of Nur77 from the nucleus to the mitochondria. However, inhibition of the relocation of Nur77 to mitochondria via Cyclosporin A reversed the changes in membrane potential mediated by H{sub 2}O{sub 2} and reduced myocardial cell injury. Therefore, these data provide a potential underlying mechanism for cardiac dysfunction in metabolic syndrome and the suppression of Nur77 translocation may provide an effective approach to reduce cardiac injury in the

Mitochondrial translocation of Nur77 induced by ROS contributed to cardiomyocyte apoptosis in metabolic syndrome

International Nuclear Information System (INIS)

Xu, Aibin; Liu, Jingyi; Liu, Peilin; Jia, Min; Wang, Han; Tao, Ling

2014-01-01

Highlights: • Metabolic syndrome exacerbated MI/R induced injury accompanied by decreased Nur77. • ROS led to Nur77 translocation in metabolic syndrome. • Inhibiting relocation of Nur77 to mitochondria reduced ROS-induced cardiomyocyte injury in metabolic syndrome. - Abstract: Metabolic syndrome is a major risk factor for cardiovascular diseases, and increased cardiomyocyte apoptosis which contributes to cardiac dysfunction after myocardial ischemia/reperfusion (MI/R) injury. Nur77, a nuclear orphan receptor, is involved in such various cellular events as apoptosis, proliferation, and glucose and lipid metabolism in several cell types. Apoptosis is positively correlated with mitochondrial translocation of Nur77 in the cancer cells. However, the roles of Nur77 on cardiac myocytes in patients with metabolic syndrome remain unclear. The objective of this study was to determine whether Nur77 may contribute to cardiac apoptosis in patients with metabolic syndrome after I/R injury, and, if so, to identify the underlying molecular mechanisms responsible. We used leptin-deficient (ob/ob) mice to make metabolic syndrome models. In this report, we observed that, accompanied by the substantial decline in apoptosis inducer Nur77, MI/R induced cardiac dysfunction was manifested as cardiomyopathy and increased ROS. Using the neonatal rat cardiac myocytes cultured in a high-glucose and high-fat medium, we found that excessive H 2 O 2 led to the significant alteration in mitochondrial membrane potential and translocation of Nur77 from the nucleus to the mitochondria. However, inhibition of the relocation of Nur77 to mitochondria via Cyclosporin A reversed the changes in membrane potential mediated by H 2 O 2 and reduced myocardial cell injury. Therefore, these data provide a potential underlying mechanism for cardiac dysfunction in metabolic syndrome and the suppression of Nur77 translocation may provide an effective approach to reduce cardiac injury in the process

Metabolic syndrome enhances endoplasmic reticulum, oxidative stress and leukocyte-endothelium interactions in PCOS.

Science.gov (United States)

Bañuls, Celia; Rovira-Llopis, Susana; Martinez de Marañon, Aranzazu; Veses, Silvia; Jover, Ana; Gomez, Marcelino; Rocha, Milagros; Hernandez-Mijares, Antonio; Victor, Victor M

2017-06-01

Polycystic ovary syndrome (PCOS) is associated with insulin resistance, which can lead to metabolic syndrome (MetS). Oxidative stress and leukocyte-endothelium interactions are related to PCOS. Our aim was to evaluate whether the presence of MetS in PCOS patients can influence endoplasmic reticulum (ER) and oxidative stress and leukocyte-endothelium interactions. This was a prospective controlled study conducted in an academic medical center. The study population consisted of 148 PCOS women (116 without/32 with MetS) and 112 control subjects (87 without / 25 with MetS). Metabolic parameters, reactive oxygen species (ROS) production, ER stress markers (GRP78, sXBP1, ATF6), leukocyte-endothelium interactions, adhesion molecules (VCAM-1, ICAM-1, E-Selectin), TNF-α and IL-6 were determined. Total ROS, inflammatory parameters and adhesion molecules were enhanced in the presence of MetS (pPCOS+MetS group showed higher levels of IL-6 and ICAM-1 than controls (pPCOS and PCOS+MetS groups vs their respective controls (pPCOS groups (pPCOS+MetS patients exhibited higher GRP78 and ATF6 levels than controls and PCOS patients without MetS (pPCOS women, HOMA-IR was positively correlated with ICAM-1 (r=0.501; pPCOS, all of which are related to vascular complications. Copyright © 2017 Elsevier Inc. All rights reserved.

48 CFR 31.205-35 - Relocation costs.

Science.gov (United States)

2010-10-01

... employees retain ownership of a vacated home in the old location and rent at the new location. The rented... work location (for a period of 12 months or more) of an existing employee or upon recruitment of a new employee. The following types of relocation costs are allowable as noted, subject to the limitations in...

Prevalence of Burnout Syndrome in Patients Admitted with Acute Coronary Syndrome

Directory of Open Access Journals (Sweden)

Ana Cláudia Giaxa Prosdócimo

2015-03-01

Full Text Available Background: Burnout Syndrome is the extreme emotional response to chronic occupational stress, manifesting as physical and mental exhaustion. Although associated with higher prevalence of cardiovascular risk factors, no study so far has evaluated whether the Burnout Syndrome could be a prevalent factor in non-elderly individuals active in the labor market, admitted for acute coronary syndrome (ACS. Objective: To evaluate the prevalence of the Burnout Syndrome in non-elderly, economically active patients, hospitalized with ACS. Methods: Cross-sectional study conducted in a tertiary and private cardiology center, with economically active patients aged <65 years, hospitalized with diagnosis of ACS. The Burnout Syndrome was evaluated with the Burnout Syndrome Inventory (BSI, which assesses workplace conditions and four dimensions that characterize the syndrome: emotional exhaustion (EE, emotional distancing (EmD, dehumanization (De and professional fulfillment (PF. The Lipp’s Stress Symptoms Inventory for Adults (LSSI was applied to evaluate global stress. Results: Of 830 patients evaluated with suspected ACS, 170 met the study criteria, 90% of which were men, overall average age was 52 years, and 40.5% had an average income above 11 minimum wages. The prevalence of the Burnout Syndrome was 4.1%. When we evaluated each dimension individually, we found high EE in 34.7%, high De in 52.4%, high EDi in 30.6%, and low PF in 5.9%. The overall prevalence of stress was 87.5%. Conclusion: We found a low prevalence of Burnout Syndrome in an economically active, non-elderly population among patients admitted for ACS in a tertiary and private hospital.

Correlation between Oxidative Stress and Thyroid Function in Patients with Nephrotic Syndrome

Directory of Open Access Journals (Sweden)

Sangita U. Sawant

2011-01-01

Full Text Available Background. The present study is to look for a correlation between oxidative stress and thyroid function in patients with the nephrotic syndrome in the remission phase as well as in a persistent proteinuric state. Introduction. Nephrotic syndrome is a form of chronic kidney disease due to which blood loses protein through the urine. We wanted to know if there was an increased loss of thyroid hormones in urine affecting thyroid function. Methods. 60 patients with nephrotic syndrome and 20 healthy non-proteinuric individuals as control subjects were enrolled in the study. We measured their serum tri-iodothyronine, thyroxine and thyroid-stimulating hormone. Estimation of lipid peroxidation (LPx catalase, superoxide dismutase (SOD, and Glutathione peroxidase (GPx were carried out by standard methods. Results. TSH was elevated in the nephrotic patients compared to controls, while TT4 and TT3 were significantly lower in the patients than in controls. Lipid Peroxidation and GPx were significantly higher in the nephrotic syndrome patients than in the controls, while SOD and catalase were significantly lower than in patients than in the control subjects. Conclusion. Nephrotic patients can lose significant amounts of thyroid hormones along with protein in urine, which can affect thyroid status, but this is reversible on remission.

Work environment perceptions following relocation to open-plan offices: A twelve-month longitudinal study.

Science.gov (United States)

Bergström, Jessica; Miller, Michael; Horneij, Eva

2015-01-01

A workplace's design can have various positive or negative effects on the employees and since the 1970s the advantages and disadvantages of open-plan offices have been discussed. The aim of this study was to investigate perceived health, work environment and self-estimated productivity one month before and at three, six and twelve months after relocation from individual offices to an open-plan office environment. Employees from three departments within the same company group and who worked with relatively similar tasks and who were planned to be relocated from private offices to open-plan offices were invited to participate. Questionnaires comprising items from The Salutogenic Health Indicator Scale, The Work Experience Measurement Scale, the questionnaire by Brennan et al. about perceived performance and one question from the Work Ability Index were sent to participants one month before relocation (baseline) to open-plan offices and then at three, six and twelve months after relocation. At baseline, 82 questionnaires were sent out. The response rate was 85%. At the follow-ups 77-79 questionnaires were sent out and the response-rate was 70%-81%. At follow-ups, perceived health, job satisfaction and performance had generally deteriorated. The results of the study indicate that employees' perception of health, work environment and performance decreased during a 12 month period following relocation from individual offices to open-plan offices.

Using an ecological ethics framework to make decisions about the relocation of wildlife

Science.gov (United States)

McCoy, E.D.; Berry, K.

2008-01-01

Relocation is an increasingly prominent conservation tool for a variety of wildlife, but the technique also is controversial, even among conservation practitioners. An organized framework for addressing the moral dilemmas often accompanying conservation actions such as relocation has been lacking. Ecological ethics may provide such a framework and appears to be an important step forward in aiding ecological researchers and biodiversity managers to make difficult moral choices. A specific application of this framework can make the reasoning process more transparent and give more emphasis to the strong sentiments about non-human organisms held by many potential users. Providing an example of the application of the framework may also increase the appeal of the reasoning process to ecological researchers and biodiversity managers. Relocation as a conservation action can be accompanied by a variety of moral dilemmas that reflect the interconnection of values, ethical positions, and conservation decisions. A model that is designed to address moral dilemmas arising from relocation of humans provides/demonstrates/illustrates a possible way to apply the ecological ethics framework and to involve practicing conservationists in the overall decision-making process. ?? 2008 Springer Science+Business Media B.V.

Preliminary results of teleseismic double-difference relocation of earthquakes around Indonesian archipelago region

Energy Technology Data Exchange (ETDEWEB)

Nugraha, Andri Dian, E-mail: andridn104@gmail.com; Widiyantoro, Sri [Global Geophysical Research Group, Faculty of Mining and Petroleum Engineering, Institut Teknologi Bandung (Indonesia); Shiddiqi, Hasbi Ash [Earth Sciences Graduate Program, Faculty of Earth Sciences and Technology, Institut Teknologi Bandung (Indonesia); Ramdhan, Mohamad; Wandono,; Sutiyono,; Handayani, Titi; Nugroho, Hendro [Agency for Meteorology, Climatology, and Geophysics (BMKG), Jakarta (Indonesia)

2015-04-24

Indonesian archipelago region is located in active tectonic setting and high seismicity zone. During the last decade, Indonesian was experienced with destructive major earthquakes causing damage and victims. The information of precise earthquake location parameters are very important in partular for earthquake early warning to the society and for advance seismic studies. In this study, we attempted to improve hypocenter location compiled by BMKG for time periods of April, 2009 up to June, 2014 for about 22,000 earthquake events around Indonesian region. For the firts time, we applied teleseismic double-difference relocation algorithm (teletomoDD) to improve hypocenter region in Indonesia region combining regional and teleseismic stations. Hypocenter relocation was performed utilizing local, regional, and teleseismic P-wave arrival time data. Our relocation result show that travel-time RMS errors were greatly reduced compared to the BMKG catalog. Seismicity at shallower depth (less than 50 km) shows significantly improvement especially in depth, and refined shallow geological structures, e.g. trench and major strike slip faults. Clustered seismicity is also detected beneath volcanic region, and probably related volcano activities and also major faults nearby. In the Sunda arc region, seismicity at shallower depth centered at two major distributions parallel to the trench strike direction, i.e. around fore-arc and in mainland that related to major fault, e.g. the Sumatran fault, and volcanic fronts. Below Central Java region, relocated hypocenter result showed double seismic zone pattern. A seismic gap is detected around the Sunda-Banda transition zone where transition between oceanic subduction to continental crust collision of Australian plate occurs. In Eastern Indonesia region, shallow earthquakes are observed related to major strike slip faults, e.g. Sorong and Palu-Koro fault, volcanism, and shallow part of subduction and collision zones. We also compare our

Hypocenter relocation along the Sunda arc in Indonesia, using a 3D seismic velocity model

Science.gov (United States)

Nugraha, Andri Dian; Shiddiqi, Hasbi A.; Widiyantoro, Sri; Thurber, Clifford H.; Pesicek, Jeremy D.; Zhang, Haijiang; Wiyono, Samsul H.; Ramadhan, Mohamad; Wandano,; Irsyam, Mahsyur

2018-01-01

The tectonics of the Sunda arc region is characterized by the junction of the Eurasian and Indo‐Australian tectonic plates, causing complex dynamics to take place. High‐seismicity rates in the Indonesian region occur due to the interaction between these tectonic plates. The availability of a denser network of seismometers after the earthquakes of Mw">Mw 9.1 in 2004 and  Mw">Mw 8.6 in 2005 supports various seismic studies, one of which regards the precise relocation of the hypocenters. In this study, hypocenter relocation was performed using a teleseismic double‐difference (DD) relocation method (teletomoDD) combining arrival times of P and S waves from stations at local, regional, and teleseismic distances. The catalog data were taken from the Agency of Meteorology, Climatology, and Geophysics (BMKG) of Indonesia, and the International Seismological Centre (ISC) for the time period of April 2009 to May 2015. The 3D seismic‐wave velocity model with a grid size 1°×1°">1°×1° was used in the travel‐time calculations. Relocation results show a reduction in travel‐time residuals compared with the initial locations. The relocation results better illuminate subducted slabs and active faults in the region such as the Mentawai back thrust and the outer rise in the subduction zone south of Java. Focal mechanisms from the Global Centroid Moment Tensor catalog are analyzed in conjunction with the relocation results, and our synthesis of the results provides further insight into seismogenesis in the region.

Perceptions of performance and satisfaction after relocation to an activity-based office.

Science.gov (United States)

Rolfö, Linda; Eklund, Jörgen; Jahncke, Helena

2018-05-01

Many companies move from open-plan offices (OPO) to activity-based workplaces (ABWs). However, few studies examine the benefits and drawbacks following such a change. The aim of this study was to explore how physical conditions, office use, communication, privacy, territoriality, satisfaction and perceived performance change following a company's relocation from an OPO to an ABW. A mixed methods approach included pre- and post-relocation questionnaires and post-relocation focus groups, individual interviews and observations. The questionnaires enabled comparisons over time (n = 34) and broader analyses based on retrospective ratings of perceived change (n = 66). Results showed that satisfaction with auditory privacy, background noise, air quality, outdoor view and aesthetics increased significantly after relocation. Negative outcomes, such as lack of communication within teams, were perceived as being due to the high people-to-workstation ratio and lack of rules. Overall satisfaction with the physical work environment increased in the ABW compared to the OPO. Perceived performance did not change significantly. Practitioner Summary: Activity-based workplaces (ABWs) are commonly implemented although their effects on performance and well-being are unclear. This case study gives advice to stakeholders involved in office planning. Despite shortcomings with the people-to-workstation ratio and rules, employees showed improved satisfaction with auditory privacy and aesthetics in the ABW compared with the previous open-plan office.

Effects of fuel relocation on reflood in a partially-blocked rod bundle

Energy Technology Data Exchange (ETDEWEB)

Kim, Byoung Jae [School of Mechanical Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134 (Korea, Republic of); Kim, Jongrok; Kim, Kihwan; Bae, Sung Won [Thermal-Hydraulic Safety Research Division, Korea Atomic Energy Research Division, 111 Daedeok-daero, Yuseong-gu, Daejeon 34057 (Korea, Republic of); Moon, Sang-Ki, E-mail: skmoon@kaeri.re.kr [Thermal-Hydraulic Safety Research Division, Korea Atomic Energy Research Division, 111 Daedeok-daero, Yuseong-gu, Daejeon 34057 (Korea, Republic of)

2017-02-15

Ballooning of the fuel rods has been an important issue, since it can influence the coolability of the rod bundle in a large-break loss-of-coolant accident (LBLOCA). Numerous past studies have investigated the effect of blockage geometry on the heat transfer in a partially blocked rod bundle. However, they did not consider the occurrence of fuel relocation and the corresponding effect on two-phase heat transfer. Some fragmented fuel particles located above the ballooned region may drop into the enlarged volume of the balloon. Accordingly, the fuel relocation brings in a local power increase in the ballooned region. The present study’s objective is to investigate the effect of the fuel relocation on the reflood under a LBLOCA condition. Toward this end, experiments were performed in a 5 × 5 partially-blocked rod bundle. Two power profiles were tested: one is a typical cosine shape and the other is the modified shape considering the effect of the fuel relocation. For a typical power shape, the peak temperature in the ballooned rods was lower than that in the intact rods. On the other hand, for the modified power shape, the peak temperature in the ballooned rods was higher than that in the intact rods. Numerical simulations were also performed using the MARS code. The tendencies of the peak clad temperatures were well predicted.

76 FR 48863 - Federal Travel Regulation (FTR); Relocation Allowances-Standard Mileage Rate for Moving Purposes

Science.gov (United States)

2011-08-09

... Travel Regulation (FTR); Relocation Allowances--Standard Mileage Rate for Moving Purposes AGENCY: Office... agencies will reimburse an employee for using a privately owned vehicle for relocation on a worldwide basis...), Office of Travel, Transportation and Asset Management (MT), General Services Administration at (202) 208...

41 CFR 302-3.507 - Once we authorize relocation expenses for new appointees or student trainees what expenses must...

Science.gov (United States)

2010-07-01

... relocation expenses for new appointees or student trainees what expenses must we pay? 302-3.507 Section 302-3.507 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES....507 Once we authorize relocation expenses for new appointees or student trainees what expenses must we...

Sleep in Children and Adolescents with Angelman Syndrome: Association with Parent Sleep and Stress

Science.gov (United States)

Goldman, S. E.; Bichell, T. J.; Surdyka, K.; Malow, B. A.

2012-01-01

Background: Sleep concerns are common in children with Angelman syndrome, with 20-80% of individuals having a decreased sleep need and/or abnormal sleep-wake cycles. The impact of these sleep behaviours on parental sleep and stress is not known. Method: Through the use of standardised questionnaires, wrist actigraphy and polysomnography, we…

Temperature Discontinuity Caused by Relocation of Meteorological Stations in Taiwan

Directory of Open Access Journals (Sweden)

Chih-wen Hung

2009-01-01

Full Text Available With global warming upon us, it has be come increasingly important to identify the extent of this warming trend and in doing so be able to rank mean temperature changes in particular seasons and years. This requires a need for homogeneous climate data, which do not reflect individual anomalies in instruments, station locations or local environments (urbanization. Ac curate homogeneous long-term meteorological data helps show how temperature variations have truly occurred in the climate. Many possible factors contribute to artificial abrupt changes or sharp discontinuities in long time series data, such as the impact of station relocation, changes in observational schedules and instrumentation. Homogeneity adjustments of in situ climate data are very important processes for preparing observational data to be used in further analysis and research. Users require a well-documented history of stations to make appropriate homogeneity adjustments because precise historical back ground records of stations can provide researchers with knowledge of when artificial discontinuity has occurred and its causes. With out such de tailed historical data for each meteorological station, abrupt changes are difficult to interpret. Unfortunately, no homogeneity adjustments for temperature records have been con ducted previously in Tai wan, and present available sources of the history of Taiwan's meteorological stations exhibit in consistencies. In this study, information pertaining to station history, especially relocation records, is pro vided. This information is essential for anal y sis of continuous time series data for temperature and climate warming studies. Temperature data from several stations is given in this study to show how artificial discontinuity occurs due to station relocation. Al though there is no homogeneous adjusted climate data provided in this preliminary work, the summarizing of information regarding station relocations should be of assistance

Parenting Stress and Coping Styles in Mothers and Fathers of Pre-School Children with Autism and Down Syndrome

Science.gov (United States)

Dabrowska, A.; Pisula, E.

2010-01-01

Background: The study examined the profile of stress in mothers and fathers of preschool children with autism, Down syndrome and typically developing children. A further aim was to assess the association between parenting stress and coping style. Methods: A total of 162 parents were examined using Holroyd's 66-item short form of Questionnaire of…

Heatup of the TMI-2 lower head during core relocation

International Nuclear Information System (INIS)

Wang, S.K.; Sienicki, J.J.; Spencer, B.W.

1989-01-01

An analysis has been carried out to assess the potential of a melting attack upon the reactor vessel lower head and incore instrument nozzle penetration weldments during the TMI core relocation event at 224 minutes. Calculations were performed to determine the potential for molten corium to undergo breakup into droplets which freeze and form a debris bed versus impinging upon the lower head as one or more coherent streams. The effects of thermal-hydraulic interactions between corium streams and water inside the lower plenum, the effects of the core support assembly structure upon the corium, and the consequences of corium relocation by way of the core former region were examined. 19 refs., 24 figs

76 FR 18325 - Federal Travel Regulation; FTR Cases 2007-304 and 2003-309, Relocation Allowances

Science.gov (United States)

2011-04-01

... envisions agencies using commercial off-the-shelf software, data warehousing systems, or tools built by the.... GSA agrees and changed the definition. Data Systems, Reporting, and Relocation Program Management The... single electronic environment. Also, GSA removed the due date for agencies to report relocation data from...

Stress-Related Alterations of Visceral Sensation: Animal Models for Irritable Bowel Syndrome Study

Science.gov (United States)

Mulak, Agata; Taché, Yvette

2011-01-01

Stressors of different psychological, physical or immune origin play a critical role in the pathophysiology of irritable bowel syndrome participating in symptoms onset, clinical presentation as well as treatment outcome. Experimental stress models applying a variety of acute and chronic exteroceptive or interoceptive stressors have been developed to target different periods throughout the lifespan of animals to assess the vulnerability, the trigger and perpetuating factors determining stress influence on visceral sensitivity and interactions within the brain-gut axis. Recent evidence points towards adequate construct and face validity of experimental models developed with respect to animals' age, sex, strain differences and specific methodological aspects such as non-invasive monitoring of visceromotor response to colorectal distension as being essential in successful identification and evaluation of novel therapeutic targets aimed at reducing stress-related alterations in visceral sensitivity. Underlying mechanisms of stress-induced modulation of visceral pain involve a combination of peripheral, spinal and supraspinal sensitization based on the nature of the stressors and dysregulation of descending pathways that modulate nociceptive transmission or stress-related analgesic response. PMID:21860814

WAGES AND COMMUTING: QUASI-NATURAL EXPERIMENTS’ EVIDENCE FROM FIRMS THAT RELOCATE

DEFF Research Database (Denmark)

Mulalic, Ismir; N. Van Ommeren, Jos; Pilegaard, Ninette

2014-01-01

We examine individual-level compensating differentials for commuting distance in a quasi-natural experiment setting by examining how wages respond to changes in commuting distance induced by firm relocations. This set-up enables us to test for the relevance of job search frictions within labour...... market models. Due to the quasi-experimental set-up, we are able to avoid a range of endogeneity issues. We demonstrate that a 1 km increase in commuting distance induces an almost negligible wage increase in the year after the relocation but a more substantial wage increase of about 0.15% three years...

Wages and commuting: quasi-natural experiments' evidence from firms that relocate

DEFF Research Database (Denmark)

Mulalic, Ismir; N. Van Ommeren, Jos; Pilegaard, Ninette

2014-01-01

We examine individual-level compensating differentials for commuting distance in a quasi-natural experiment setting by examining how wages respond to changes in commuting distance induced by firm relocations. This set-up enables us to test for the relevance of job search frictions within labour...... market models. Due to the quasi-experimental set-up, we are able to avoid a range of endogeneity issues. We demonstrate that a 1 km increase in commuting distance induces an almost negligible wage increase in the year after the relocation but a more substantial wage increase of about 0.15% three years...

Association of Symptoms Following Mild Traumatic Brain Injury With Posttraumatic Stress Disorder vs Postconcussion Syndrome

DEFF Research Database (Denmark)

Lagarde, E.; Salmi, L. R.; Holm, L. W.

2014-01-01

, there is controversy whether PCS deserves to be identified as a diagnostic syndrome. OBJECTIVE To assess whether persistent symptoms 3 months following head injury are specific to MTBI or whether they are better described as part of posttraumatic stress disorder (PTSD). DESIGN, SETTING, AND PARTICIPANTS We conducted...

Accurate relocation of seismicity along the North Aegean Trough and its relation to active tectonics

Science.gov (United States)

Konstantinou, K. I.

2017-10-01

The tectonics of northern Aegean are affected by the westward push of Anatolia and the gravitational spreading of the Aegean lithosphere that promote transtensional deformation in the area. This regime is also responsible for the creation of a series of pull-apart basins, collectively known as the North Aegean Trough. This work accurately relocates a total of 2300 earthquakes that were recorded along the North Aegean Trough during 2011-2016 by stations of the Hellenic Unified Seismic Network (HUSN) and strong-motion sensors. Absolute locations for these events were obtained using a nonlinear probabilistic algorithm and utilizing a minimum 1D velocity model with station corrections. The hypocentral depth distribution of these events shows a peak at 8 km diminishing gradually down to 20 km. A systematic overestimation of hypocentral depths is observed in the routine locations provided by the National Observatory of Athens where the majority of events appear to be deeper than 15 km. In order to obtain more accurate relative locations these events were relocated using the double-difference method. A total of 1693 events were finally relocated with horizontal and vertical uncertainties that do not exceed 0.11 km and 0.22 km respectively. Well-defined clusters of seismicity can be observed along the Saros and Sporades basins as well as the Kassandra and Sithonia peninsulas. These clusters either occur along the well-known NE-SW strike-slip faults bounding the basins, or along normal faults whose strike is perpendicular to the regional minimum stress axis. Locking depth along the North Aegean Trough is found to be remarkably stable between 13 and 17 km. This is likely a consequence of simultaneous reduction along the SW direction of heat flow (from 89 to 51 mW/m2) and strain rate (from 600 to 50 nstrain/yr) whose opposite effects are canceled out, precluding any sharp changes in locking depth.

Optimization of hospital ward resources with patient relocation using Markov chain modeling

DEFF Research Database (Denmark)

Andersen, Anders Reenberg; Nielsen, Bo Friis; Reinhardt, Line Blander

2017-01-01

available to the hospital. Patient flow is modeled using a homogeneous continuous-time Markov chain and optimization is conducted using a local search heuristic. Our model accounts for patient relocation, which has not been done analytically in literature with similar scope. The study objective is to ensure...... are distributed. Furthermore, our heuristic is found to efficiently derive the optimal solution. Applying our model to the hospital case, we found that relocation of daily arrivals can be reduced by 11.7% by re-distributing beds that are already available to the hospital....

Residential relocation and change in social capital: A natural experiment from the 2011 Great East Japan Earthquake and Tsunami.

Science.gov (United States)

Hikichi, Hiroyuki; Sawada, Yasuyuki; Tsuboya, Toru; Aida, Jun; Kondo, Katsunori; Koyama, Shihoko; Kawachi, Ichiro

2017-07-01

Social connections in the community ("social capital") represent an important source of resilience in the aftermath of major disasters. However, little is known about how residential relocation due to housing destruction affects survivors' social capital. We examined changes in social capital among survivors of the 2011 Great East Japan Earthquake and Tsunami. People who lost their homes were resettled to new locations by two primary means: (i) group relocation to public temporary trailer housing or (ii) individual relocation, in which victims moved into government-provided housing by lottery or arranged for their own accommodation (market rental housing or private purchase/new construction). The baseline for our natural experiment was established 7 months before the 11 March 2011 disaster, when we conducted a survey of older community-dwelling adults who lived 80-km west of the earthquake epicenter. Approximately 2.5 years after the disaster, the follow-up survey gathered information about personal experiences of disaster as well as health status and social capital. Among 3421 people in our study, 79 people moved via group relocation to public temporary trailer housing, whereas 96 people moved on their own. The individual fixed-effects model showed that group relocation was associated with improved informal socializing and social participation (β coefficient = 0.053, 95% confidence interval: 0.011 to 0.095). In contrast, individual relocation was associated with declining informal socializing and social participation (β coefficient = -0.039, 95% confidence interval: -0.074 to -0.003). Group relocation, as compared to individual relocation, appeared to preserve social participation and informal socializing in the community.

Oxidative stress in the pathophysiology of metabolic syndrome: which mechanisms are involved?

Directory of Open Access Journals (Sweden)

Thalia M. T. Avelar

2015-08-01

Full Text Available ABSTRACTMetabolic syndrome (MS is a combination of cardiometabolic risk factors, including obesity, hyperglycemia, hypertriglyceridemia, dyslipidemia and hypertension. Several studies report that oxidative condition caused by overproduction of reactive oxygen species (ROS plays an important role in the development of MS. Our body has natural antioxidant system to reduce oxidative stress, which consists of numerous endogenous and exogenous components and antioxidants enzymes that are able to inactivate ROS. The main antioxidant defense enzymes that contribute to reduce oxidative stress are superoxide dismutase (SOD, catalase (CAT and gluthatione peroxidase (GPx. The high-density lipoprotein cholesterol (HDL-c is also associated with oxidative stress because it presents antioxidant and anti-inflammatory properties. HDL-c antioxidant activity may be attributed at least in part, to serum paraoxonase 1 (PON1 activity. Furthermore, derivatives of reactive oxygen metabolites (d-ROMs also stand out as acting in cardiovascular disease and diabetes, by the imbalance in ROS production, and close relationship with inflammation. Recent reports have indicated the gamma-glutamyl transferase (GGT as a promising biomarker for diagnosis of MS, because it is related to oxidative stress, since it plays an important role in the metabolism of extracellular glutathione. Based on this, several studies have searched for better markers for oxidative stress involved in development of MS.

22q11.2 deletion syndrome: behaviour problems of children and adolescents and parental stress.

Science.gov (United States)

Briegel, W; Schneider, M; Schwab, K Otfried

2008-11-01

22q11.2 deletion syndrome can be associated with a variety of somatic symptoms, developmental delays and psychiatric disorders. At present, there is little information on behaviour problems, parental stress and possible relations between these factors. Therefore, this study investigates behaviour problems of children and adolescents with 22q11.2DS, and their primary caregivers' stress. Parents of 4-17 year old subjects known to the German 22q11.2 deletion syndrome foundation were anonymously asked to fill out several questionnaires, e.g. the Child Behavior Checklist 4-18 (CBCL/4-18). The primary caregivers of 77/126 children [43 males, 34 females, mean age: 8;0 (4;0-16;11) years] sent back filled-out questionnaires. Forty-six of 76 subjects were rated as clinical on at least one of the CBCL-scales. Males had significantly higher scores on the total problems scale and the internalizing problems scale than females. The patients' age correlated with several CBCL-scales. Eleven of 49 subjects were suspicious of an autism spectrum disorder. Compared with the general population, but not with other parents of mentally and/or physically handicapped children, the primary caregivers experienced higher levels of stress, but showed normal life satisfaction. In spite of high rates of clinical behaviour problems among children and adolescents with 22q11.2DS and despite increased parental stress, most primary caregivers seem to have effective coping strategies, e.g. partnership support, to sustain normal levels of life satisfaction.

Stress cardiomyopathy: Is it limited to Takotsubo syndrome? Problems of definition.

Science.gov (United States)

Sarapultsev, Petr A; Sarapultsev, Alexey P

2016-10-15

In 2006, Takotsubo syndrome (TTC) was described as a distinct type of stress-induced cardiomyopathy (stress cardiomyopathy). However, when thinking about Takotsubo cardiomyopathy from the viewpoints of the AHA and ESC classifications, 2 possible problems may arise. The first potential problem is that a forecast of disease outcome is lacking in the ESC classification, whereas the AHA only states that 'outcome is favorable with appropriate medical therapy'. However, based on the literature data, one can make a general conclusion that occurrence of myocardial lesions in TTC (i.e., myocardial fibrosis and contraction-band necrosis) causes the same effects as in other diseases with similar levels of myocardial damage and should not be considered to have a lesser impact on mortality. To summarise, TTC can cause not only severe complications such as pulmonary oedema, cardiogenic shock, and dangerous ventricular arrhythmias, but also damage to the myocardium, which can result in the development of potentially fatal conditions even after the disappearance of LV apical ballooning. The second potential problem arises from the definition of TTC as a stress cardiomyopathy in the AHA classification. In fact, the main factors leading to TTC are stress and microvascular anginas, since, as has been already discussed, coronary spasm can cause myocardium stunning, resulting in persistent apical ballooning. Thus, based on this review, 3 distinct types of stress cardiomyopathies exist (variant angina, microvascular angina, and TTC), with poor prognosis. Adding these diseases to the classification of cardiomyopathies will facilitate diagnosis and preventive prolonged treatment, which should include intensive anti-stress therapy. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Teachers` and medics' burnout syndrome

OpenAIRE

VOPELKOVÁ, Kateřina

2010-01-01

The bachelor thesis offers an overview of information related to problems of stress and burnout syndrome. I deal mainly with causes, symptoms, risk factors, prevention and getting stress and burnout syndrome under control. The aim of my bachelor thesis is to find out symptoms of burnout syndrome at teachers and health service employees. I supposed different manifestations of the burnout syndrome due to different demands put on these people in their professions. Another aim was to establish th...

Negotiating a Concurrence: Tracing the Visible/Invisible Relocation within Migrant-Inhabited Cities of China

Directory of Open Access Journals (Sweden)

Xueni Peng

2015-04-01

China’s internal migrants experience hardship akin to those undergone by overseas immigrants. In this respect, migration in China is an experience that begins before people move away from their place of origin and continues long after arriving in their new home destinations. As a unique feature of migration research, national relocation is not simply crossing a geographical boundary, but also transgressing social and psychological environment barriers. Our research intends to examine the underestimated or marginal character played by such outsider crowds with special regard given to the individual’s experience of ‘unfamiliar settlements. This involves exploring the role of migrants’ transformation through the misapprehension that relocation is merely a geographical movement. We suggest that visible relocation brings other incidental replacements (such as changes in identity, psychological cognition and social cohesion.

Selye's general adaptation syndrome: stress-induced gastro-duodenal ulceration and inflammatory bowel disease.

Science.gov (United States)

Fink, George

2017-03-01

Hans Selye in a note to Nature in 1936 initiated the field of stress research by showing that rats exposed to nocuous stimuli responded by way of a 'general adaptation syndrome' (GAS). One of the main features of the GAS was the 'formation of acute erosions in the digestive tract, particularly in the stomach, small intestine and appendix'. This provided experimental evidence for the view based on clinical data that gastro-duodenal (peptic) ulcers could be caused by stress. This hypothesis was challenged by Marshall and Warren's Nobel Prize (2005)-winning discovery of a causal association between Helicobacter pylori and peptic ulcers. However, clinical and experimental studies suggest that stress can cause peptic ulceration in the absence of H. pylori Predictably, the etiological pendulum of gastric and duodenal ulceration has swung from 'all stress' to 'all bacteria' followed by a sober realization that both factors play a role, separately as well as together. This raises the question as to whether stress and H. pylori interact, and if so, how? Stress has also been implicated in inflammatory bowel disease (IBD) and related disorders; however, there is no proof yet that stress is the primary etiological trigger for IBD. Central dopamine mechanisms seem to be involved in the stress induction of peptic ulceration, whereas activation of the sympathetic nervous system and central and peripheral corticotrophin-releasing factor appears to mediate stress-induced IBD. © 2017 Society for Endocrinology.

Final hazard classification for N basin water filtration and sediment relocation operations

International Nuclear Information System (INIS)

Pisarcik, D.J.; Kretzschmar, S.P.

1996-02-01

This document provides an auditable safety analysis and hazard classification for the filtration of basin water and the relocation of 105-N basin solids to the North Cask Pit within the basin complex. This report assesses the operation of the Water Filtration System and the Remotely Operated Sediment Extraction Equipment (ROSEE). These activities have an activity hazard classification of radiological. Inventories of potentially releasable nonradioactive hazardous materials are far below the reportable quantities of 40 CFR 302. No controls are required to maintain the releasable inventories of these materials below the reportable quantities. Descriptive material is included to provide a general understanding of the water filtration and sediment relocation processes. All equipment will be operated as described in work instructions and/or applicable procedures. Special controls associated with these activities are as follows: (1) A leak inspection of the ROSEE system shall be performed at least once every 5-hour period of sediment relocation operation. (2) A berm must be in place around the North Cask Pit to redirect a potential abovewater ROSEE system leak back to the basin

Burnout syndrome in medical professionals: a manifestation of chronic stress with counterintuitive passive characteristics.

Science.gov (United States)

Ptacek, Radek; Stefano, George B; Kuzelova, Hana; Raboch, Jiri; Harsa, Pavel; Kream, Richard M

2013-01-01

By operational criteria, burnout appears to be a multifaceted behavioral syndrome consisting of maladaptive individual responses subsequent to prolonged stressful situations. Given the intense physical and cognitive demands of providing high quality healthcare to a wide spectrum of patients, healthcare professionals are particularly susceptible to developing burnout syndrome, a notable phenomenon that has gleaned significant societal attention in recent years. Clearly, widespread manifestation of burnout by health care professionals represents a serious potential threat to the overall quality of patient care and to the realization of positive outcomes to multiple treatment strategies. It will most certainly engender a serious negative impact on the economic viability of the entire healthcare system. Presently, our brief review focuses on current research efforts to 1) provide precise behavioral and psychiatric diagnostic criteria for burnout syndrome in healthcare professionals, 2) identify potential etiological factors and ongoing stressors, and 3) outline an integrative approach for treatment and prevention.

Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome.

Science.gov (United States)

Kuo, Lydia E; Kitlinska, Joanna B; Tilan, Jason U; Li, Lijun; Baker, Stephen B; Johnson, Michael D; Lee, Edward W; Burnett, Mary Susan; Fricke, Stanley T; Kvetnansky, Richard; Herzog, Herbert; Zukowska, Zofia

2007-07-01

The relationship between stress and obesity remains elusive. In response to stress, some people lose weight, whereas others gain. Here we report that stress exaggerates diet-induced obesity through a peripheral mechanism in the abdominal white adipose tissue that is mediated by neuropeptide Y (NPY). Stressors such as exposure to cold or aggression lead to the release of NPY from sympathetic nerves, which in turn upregulates NPY and its Y2 receptors (NPY2R) in a glucocorticoid-dependent manner in the abdominal fat. This positive feedback response by NPY leads to the growth of abdominal fat. Release of NPY and activation of NPY2R stimulates fat angiogenesis, macrophage infiltration, and the proliferation and differentiation of new adipocytes, resulting in abdominal obesity and a metabolic syndrome-like condition. NPY, like stress, stimulates mouse and human fat growth, whereas pharmacological inhibition or fat-targeted knockdown of NPY2R is anti-angiogenic and anti-adipogenic, while reducing abdominal obesity and metabolic abnormalities. Thus, manipulations of NPY2R activity within fat tissue offer new ways to remodel fat and treat obesity and metabolic syndrome.

Crisis Relocation Workshops for Transportation Industry Representatives

Science.gov (United States)

1979-12-01

executive, two National Guard members, one Air Force transporta- _a ,tion representative, two Red Cross representatives, one school bus z coordinators...manaaers, local transitCD operator, and miiltary busingA authorityA Local Governa-ient 2 Fire chief, assistantI Air Force 3 Liaison Support D CPA :z...to attend the workshop. Majur trans- portation problems anticipated during crisis relocation include: 1. Transportation of carless residents; 2. The

Stress and visceral pain: focusing on irritable bowel syndrome.

Science.gov (United States)

Fukudo, Shin

2013-12-01

Recent advances in brain science have shown that the brain function encoding emotion depends on interoceptive signals such as visceral pain. Visceral pain arose early in our evolutionary history. Bottom-up processing from gut-to-brain and top-down autonomic/neuroendocrine mechanisms in brain-to-gut signaling constitute a circuit. Brain imaging techniques have enabled us to depict the visceral pain pathway as well as the related emotional circuit. Irritable bowel syndrome (IBS) is characterized by chronic recurrent abdominal pain or abdominal discomfort associated with bowel dysfunction. It is also thought to be a disorder of the brain-gut link associated with an exaggerated response to stress. Corticotropin-releasing hormone (CRH), a major mediator of the stress response in the brain-gut axis, is an obvious candidate in the pathophysiology of IBS. Indeed, administration of CRH has been shown to aggravate the visceral sensorimotor response in IBS patients, and the administration of peptidergic CRH antagonists seems to alleviate IBS pathophysiology. Serotonin (5-HT) is another likely candidate associated with brain-gut function in IBS, as 5-HT3 antagonists, 5-HT4 agonists, and antidepressants were demonstrated to regulate 5-HT neurotransmission in IBS patients. Autonomic nervous system function, the neuroimmune axis, and the brain-gut-microbiota axis show specific profiles in IBS patients. Further studies on stress and visceral pain neuropathways in IBS patients are warranted. Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

OpenAIRE

Maes, Michael; Kubera, Marta; Uytterhoeven, Marc; Vrydags, Nicolas; Bosmans, Eugene

2011-01-01

Summary Background There is evidence that myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by activation of immune, inflammatory, oxidative and nitrosative stress (IO&NS) pathways. The present study was carried out in order to examine whether ME/CFS is accompanied by increased levels of plasma peroxides and serum oxidized LDL (oxLDL) antibodies, two biomarkers of oxidative stress. Material/Methods Blood was collected from 56 patients with ME/CFS and 37 normal volun...

41 CFR 302-1.2 - Who is not eligible for relocation expense allowances under this chapter?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false Who is not eligible for relocation expense allowances under this chapter? 302-1.2 Section 302-1.2 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES INTRODUCTION 1-GENERAL RULES Applicability...

5 CFR 575.209 - Payment of relocation incentives.

Science.gov (United States)

2010-01-01

... pay periods equals 546 days, and 546 days divided by 365 days equals 1.50 years. (c)(1) An authorized... pay a relocation incentive— (1) As an initial lump-sum payment at the commencement of the service... employee in a service period may not exceed 25 percent of the annual rate of basic pay of the employee at...

Comparison tomography relocation hypocenter grid search and guided grid search method in Java island

International Nuclear Information System (INIS)

Nurdian, S. W.; Adu, N.; Palupi, I. R.; Raharjo, W.

2016-01-01

The main data in this research is earthquake data recorded from 1952 to 2012 with 9162 P wave and 2426 events are recorded by 30 stations located around Java island. Relocation hypocenter processed using grid search and guidded grid search method. Then the result of relocation hypocenter become input for tomography pseudo bending inversion process. It can be used to identification the velocity distribution in subsurface. The result of relocation hypocenter by grid search and guided grid search method after tomography process shown in locally and globally. In locally area grid search method result is better than guided grid search according to geological reseach area. But in globally area the result of guided grid search method is better for a broad area because the velocity variation is more diverse than the other one and in accordance with local geological research conditions. (paper)

Relocation consequences on an ophthalmology consultation service from an inpatient to outpatient facility

Directory of Open Access Journals (Sweden)

Singh JS

2015-10-01

Full Text Available Jorawer S Singh,1 Vincent M Imbrogno,2 Mary K Howard,3 Amandip S Cheema,3 Ausra D Selvadurai,4 Surbhi Bansal5 1Department of Ophthalmology, George Washington University, Washington, DC, 2Contemporary Ophthalmology of Erie, Erie, PA, 3Department of Ophthalmology, University at Buffalo, Buffalo, NY, 4OcuSight Eye Care Center, Rochester, NY, 5Department of Ophthalmology, Virginia Commonwealth University, Richmond, VA, USA Importance: This study shows that relocation of an academic ophthalmology residency program from an inpatient to an outpatient setting in western New York does not affect the consult volume but affects management patterns and follow-up rates.Objective: To investigate the effects on the ophthalmology consultation service of an academic program with relocation from a Regional Level-1 Trauma center to an outpatient facility.Design: Consultation notes from 3 years before and 3 years after the University at Buffalo’s (UB Department of Ophthalmology relocation from a Regional Level-1 Trauma center (Erie County Medical Center to an outpatient facility (Ross Eye Institute were obtained from hospital electronic medical records and analyzed.Setting: Hospitalized care and institutional practice.Participants: All inpatient or Emergency Room Ophthalmology consultation patients from the Department of Ophthalmology at UB from 2004 to 2010 (1,379 patients.Exposures: None, this was a retrospective chart review.Main outcome measures: Patient demographics, reason for consult, diagnoses, and ophthalmic procedures performed by the UB Department of Ophthalmology before and after its relocation.Results: Relocation to the outpatient facility did not affect consult volume (P=0.15. The number of consults focusing on ophthalmic conditions, as a percentage of the yearly total, rose 460% (P=0.0001, while systemic condition consults with ocular manifestations fell 83% (P=0.0001. Consults for ocular trauma decreased 65% (P=0.0034. Consults ending with a

(Re)creating community: Experiences of Older Women Forcibly Relocated During Apartheid.

Science.gov (United States)

Roos, Vera; Kolobe, Patricia Stockie; Keating, Norah

2014-01-01

This article explores sense of community with a group of older African women, who were forcibly relocated during apartheid. The situation of a marginalised group, with a history of disconnection from younger generations and from place, provides an opportunity to consider the relevance of community in later life. The research was conducted at a day centre for older people in the North West Province of South Africa, more than 50 years after forced relocations took place. Eleven older women (70 years and older) participated. Qualitative data were obtained through visual research methods and group discussions and were thematically analysed. Findings were that place and sense of belonging as well as elements of community were relevant. Participants reported limited connections to place in either childhood or current communities. Post relocation, a sense of belonging was expressed only in relation to a shared-interest community of peers that addressed their needs for safety, emotional support and instrumental care. Also, generational relations were strained, giving rise to a sense of loss of a community where both young and old were responsible for each other. Constrained resource communities have a profound impact on opportunities to create a sense of belonging. © 2013 The Authors. Journal of Community & Applied Social Psychology published by John Wiley & Sons Ltd.

Gender differences in the family-relatedness of relocation decisions

NARCIS (Netherlands)

Ullrich, J.; Pluut, Helen; Büttgen, M.

2015-01-01

Using a dyadic study design, the present study draws on research into the family-relatedness of work decisions to examine the impact of the spouse's characteristics on an employee's willingness to engage in job-related relocation. With a sample of 1234 employees, the results show that spousal

41 CFR 300-70.1 - What are the requirements for reporting payments for employee travel and relocation?

Science.gov (United States)

2010-07-01

... Contracts and Property Management Federal Travel Regulation System GENERAL AGENCY REQUIREMENTS 70-AGENCY REPORTING REQUIREMENTS Requirement To Report Agency Payments for Employee Travel and Relocation § 300-70.1 What are the requirements for reporting payments for employee travel and relocation? Agencies (as...

[Relocation of Espeletia grandiflora (Asteraceae) plants as a strategy for enrichment of disturbed paramo areas (PNN Chingaza, Colombia)].

Science.gov (United States)

Rojas-Zamora, Oscar; Insuasty-Torres, Jennyfer; de Cardenas, Camilo los Angeles; Ríos, Orlando Vargas

2013-03-01

Ecological restoration of the Andean paramos faces several ecological barriers mainly at the phase of dispersal and establishment of native species. With the aim to contribute to the enrichment of degraded areas, different strategies have to be developed to overcome those barriers. In this work we studied the response of individuals of Espeletia grandiflora (Asteraceae) to the relocation as a strategy for ecological restoration programs. We also evaluated the effect of size of relocated individuals on their survival and development. The work was carried out in an experimental plot at 3 424m altitude in the sector "Lagunas de Siecha" of Chingaza National Park, Colombia. We relocated 200 plants that belonged to three different size classes: 5, 10 and 15cm of initial height. The following variables were registered: survival, plant height, number of living leaves and stem diameter of each individual. We also evaluated the differences between individuals in survival and development. In terms of survival the most efficient size classes corresponded to 15cm high; the survival was 85% after two years. The relative growth rates for height and stem diameter decreases with the increase in size, but the absolute increase in height did not show significant differences between the three sizes tested. Since the stem diameter was found the strongest survival predictor after two years of relocation activities, we suggest its use as a criterion for selection of relocation individuals. The relocation of individuals of E. grandiflora had a positive side effect, carrying other species that may contribute to the enrichment and restoration of degraded areas. Among these, we found species of the genus Hypericum, as well as Arcytophyllum nitidum and Calamagrostis effusa, which should be evaluated in terms of survival and development for the subsequent implementation of the relocation strategy. In this study we verified the successful relocation of individuals of E. grandiflora as a

Soluble (Prorenin Receptor and Obstructive Sleep Apnea Syndrome: Oxidative Stress in Brain?

Directory of Open Access Journals (Sweden)

Kazuhiro Takahashi

2017-06-01

Full Text Available (Prorenin receptor ((PRR is a multi-functional molecule that is related to both the renin-angiotensin system (RAS and vacuolar H+-ATPase (v-ATPase, an ATP-dependent multi-subunit proton pump. Soluble (PRR (s(PRR, which consists of the extracellular domain of (PRR, is present in blood and urine. Elevated plasma s(PRR concentrations are reported in patients with chronic kidney disease and pregnant women with hypertension or diabetes mellitus. In addition, we have shown that plasma s(PRR concentrations are elevated in patients with obstructive sleep apnea syndrome (OSAS. Interestingly, the levels are elevated in parallel with the severity of OSAS, but are not related to the presence of hypertension or the status of the circulating RAS in OSAS. It is known that v-ATPase activity protects cells from endogenous oxidative stress, and loss of v-ATPase activity results in chronic oxidative stress. We hypothesize that hypoxia and subsequent oxidative stress, perhaps in the brain, may be one of the factors that elevate plasma s(PRR levels in OSAS.

The Evolving Law of Disputed Relocation: constructing inner-city renewal practices in Shanghai, 1990-2005.

Science.gov (United States)

Shih, Mi

2010-01-01

The forceful pursuit of inner-city renewal in Shanghai since the early 1990s has to a great extent achieved spatial modernization, but at the same time it has given rise to increasing conflicts over residential relocation. Using law as a prism through which to examine the dialectic relationship between renewal practices and disputed relocation, this article argues that the series of unprecedented enactments in law that have taken place during this period have both paved the way for real estate market expansion and been a significant source of relocation disputes in Shanghai. Rather than viewing law as simply given and determinate, the article traces the regulatory regime's codification of property practices as a means of actively responding to the requirements of the real estate market. Under large-scale renewal practices, residents' legal rights of "return settlement" (huiban) in inner-city areas were largely denied in the early 1990s, before being effectively abolished by the adoption of monetary compensation for displacement in the 2000s. The evolving law on property practices has greatly shaped the process of disputed relocation while simultaneously posing a potential challenge to China's use of law for market-oriented development.

Social support, coping strategies and their correlations with older adults' relocation adjustments after natural disaster.

Science.gov (United States)

Chao, Shiau-Fang

2017-06-01

The present study examines the associations among social support, coping strategies and relocation adjustment outcomes, including community cohesion, residential satisfaction and depressive symptoms, for older persons in Taiwan displaced by Typhoon Morakot. This study enrolled 372 adults aged 60 years or older who were relocated to permanent houses after Typhoon Morakot destroyed their homes on 8 August 2009. A path analysis simultaneously examined the hypothesized links among social support, coping strategies and relocation adjustment outcomes. The relationships between coping strategies and relocation outcomes varied. Problem-focused and support-seeking coping were positively related to perceived community cohesion, whereas emotion-focused coping was associated with a high number of depressive symptoms. Social support was positively related to residential satisfaction. Additionally, social support was also indirectly related to increased community cohesion and residential satisfaction through its positive relationship with support-seeking and problem-focused coping. More interventions should be implemented to enhance support within informal networks and a sense of belonging to the new resident community, thereby promoting more active coping strategies, enhancing the effectiveness of coping efforts and maximizing positive adjustment outcomes. Geriatr Gerontol Int 2017; 17: 1006-1014. © 2016 Japan Geriatrics Society.

Foot medial longitudinal-arch deformation during quiet standing and gait in subjects with medial tibial stress syndrome

DEFF Research Database (Denmark)

Bandholm, Thomas Quaade; Boysen, Lisbeth; Haugaard, Stine

2008-01-01

The objective of this study was to investigate (1) if subjects with medial tibial stress syndrome demonstrate increased navicular drop and medial longitudinal-arch deformation during quiet standing and gait compared with healthy subjects, and (2) the relationship between medial longitudinal-arch ...

Predictors of parenting stress among Malaysian mothers of children with Down syndrome.

Science.gov (United States)

Norizan, A; Shamsuddin, K

2010-11-01

Having children with intellectual disability can be stressful for most parents. Currently there are very few studies focusing on parenting stress among mothers of children with Down syndrome (DS) in Asia. The present study examined the level of parenting stress experienced by Malaysian mothers of children with DS and evaluated the child and maternal factors that contributed to parenting stress based on Hill's ABC-X Model (Hill 1949). We conducted a cross-sectional study of mothers of children with DS between the ages of 2-12 years during February-June 2008 in Kedah, a state in Peninsular Malaysia. We used self-administered questionnaires to gather data on parenting stress, child's birth history and current behavioural problems, as well as the maternal sociodemographic characteristics, coping styles and psychological well-being. Parental Stress Scale (PSS) was used to assess parenting stress. Measures of child's behavioural problem using Pediatric Symptom Checklist, mother's coping style using Carver et al. (1989) COPE inventory and their psychological well-being using Lovibond and Lovibond (1995) DASS21, a scale assessing depression, anxiety and stress were also carried out. The 147 mothers who participated in the study had an average age of 43.1 years (SD = 7.6 years), of whom 94.6% were married, 57.1% had secondary level education and 28.6% were working outside their home. Based on PSS, mean parenting stress was 37.6 (SD = 8.1). Parenting stress was significantly higher among mothers who reported having children with behavioural problems. However, parenting stress was modified by positive coping styles and negative maternal psychological well-being. The final model based on hierarchical regression analysis identified maternal depression and lack of acceptance as significant predictors of parenting stress rather than child's behavioural problems. Mean parenting stress among mothers of children with DS significantly differed by behavioural problems in their

Heat transfer between relocated materials and the RPV lower head

International Nuclear Information System (INIS)

Rempe, J.L.; Knudson, D.L.; Kohriyama, T.

2001-01-01

Questions about the coolability of a continuous mass of relocated corium were raised during the Three Mile Island Unit 2 (TMI-2) Vessel Investigation Project (VIP) Post-accident examinations indicate that nearly half of the material that relocated to the vessel lower head during the TMI-2 accident formed a cohesive or ''continuous'' layer. TMI-2 VIP results and other evidence suggest that conduction through this continuous layer of solidified corium materials was assisted by other cooling mechanisms. Because increased knowledge about in-vessel coolability of corium materials may assist reactor designers in demonstrating that their concepts are passively safe, there is international interest in this topic. However, data are needed to identify what cooling mechanism(s) occurred and to develop a validated model for predicting this cooling. Corium cooling models significantly impact predictions for subsequent accident progression, such as the estimated time and mode of vessel failure. Hence, improved cooling models will provide a much needed, missing component of severe accident analyses. This paper provides a critical review of research investigating the coolability of corium relocating to a water-filled lower head. Where possible, existing models and data for predicting cooling are quantitatively compared; and governing relationships are identified. Key phenomena that should be incorporated into models for predicting this heat transfer are discussed, and deficiencies in current models and available data for predicting cooling are noted. Recommendations for improving these models and for obtaining data to validate these models are also provided. (author)

Choice and necessity: relocations in the Arctic and South Pacific

Directory of Open Access Journals (Sweden)

Robin Bronen

2014-02-01

Full Text Available Relocation – whereby livelihoods, housing and public infrastructure are reconstructed in another location – may be the best adaptation response for communities whose current location becomes uninhabitable or is vulnerable to future climate-induced threats.

Final results of the XR2-1 BWR metallic melt relocation experiment

International Nuclear Information System (INIS)

Gauntt, R.O.; Humphries, L.L.

1997-08-01

This report documents the final results of the XR2-1 boiling water reactor (BWR) metallic melt relocation experiment, conducted at Sandia National Laboratories for the U.S. Nuclear Regulatory Commission. The objective of this experiment was to investigate the material relocation processes and relocation pathways in a dry BWR core following a severe nuclear reactor accident such as an unrecovered station blackout accident. The imposed test conditions (initial thermal state and the melt generation rates) simulated the conditions for the postulated accident scenario and the prototypic design of the lower core test section (in composition and in geometry) ensured that thermal masses and physical flow barriers were modeled adequately. The experiment has shown that, under dry core conditions, the metallic core materials that melt and drain from the upper core regions can drain from the core region entirely without formation of robust coherent blockages in the lower core. Temporary blockages that suspended pools of molten metal later melted, allowing the metals to continue draining downward. The test facility and instrumentation are described in detail. The test progression and results are presented and compared to MERIS code analyses. 6 refs., 55 figs., 4 tabs

The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans.

Science.gov (United States)

Heppner, Pia S; Crawford, Eric F; Haji, Uzair A; Afari, Niloofar; Hauger, Richard L; Dashevsky, Boris A; Horn, Paul S; Nunnink, Sarah E; Baker, Dewleen G

2009-01-09

There is accumulating evidence for a link between trauma exposure, posttraumatic stress disorder (PTSD) and diminished health status. To assess PTSD-related biological burden, we measured biological factors that comprise metabolic syndrome, an important established predictor of morbidity and mortality, as a correlate of long-term health risk in PTSD. We analyzed clinical data from 253 male and female veterans, corresponding to five factors linked to metabolic syndrome (systolic and diastolic blood pressure, waist-to-hip ratio and fasting measures of high-density lipoprotein (HDL) cholesterol, serum triglycerides and plasma glucose concentration). Clinical cut-offs were defined for each biological parameter based on recommendations from the World Health Organization and the National Cholesterol Education Program. Controlling for relevant variables including sociodemographic variables, alcohol/substance/nicotine use and depression, we examined the impact of PTSD on metabolic syndrome using a logistic regression model. Two-fifths (40%) of the sample met criteria for metabolic syndrome. Of those with PTSD (n = 139), 43% met criteria for metabolic syndrome. The model predicted metabolic syndrome well (-2 log likelihood = 316.650, chi-squared = 23.731, p = 0.005). Veterans with higher severity of PTSD were more likely to meet diagnostic criteria for metabolic syndrome (Wald = 4.76, p = 0.03). These findings provide preliminary evidence linking higher severity of PTSD with risk factors for diminished health and increased morbidity, as represented by metabolic syndrome.

Relocation work of temporary thermocouples for measuring the vessel cooling system in the safety demonstration test

International Nuclear Information System (INIS)

Shimazaki, Yosuke; Shinohara, Masanori; Ono, Masato; Yanagi, Shunki; Tochio, Daisuke; Iigaki, Kazuhiko

2012-05-01

It is necessary to confirm that the temperature of water cooling panel of the vessel cooling system (VCS) is controlled under the allowable working temperature during the safety demonstration test because the water cooling panel temperature rises due to stop of cooling water circulation pumps. Therefore, several temporary thermocouples are relocated to the water cooling panel near the stabilizers of RPV and the side cooling panel outlet ring header of VCS in order to observe the temperature change of VCS. The relocated thermocouples can measure the temperature change with starting of the cooling water circulation pumps of VCS. So it is confirmed that the relocated thermocouples can observe the VCS temperature change in the safety demonstration test. (author)

41 CFR 302-2.6 - May I be reimbursed for relocation expenses if I relocate to a new official station that is less...

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false May I be reimbursed for... duty station? 302-2.6 Section 302-2.6 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES INTRODUCTION 2-EMPLOYEES ELIGIBILITY REQUIREMENTS General Rules § 302...

Focusing patterns of seismicity with relocation and collapsing

Science.gov (United States)

Li, Ka Lok; Gudmundsson, Ólafur; Tryggvason, Ari; Bödvarsson, Reynir; Brandsdóttir, Bryndís

2016-07-01

Seismicity is generally concentrated on faults or in fault zones of varying, sometimes complex geometry. An earthquake catalog, compiled over time, contains useful information about this geometry, which can help understanding the tectonics of a region. Interpreting the geometrical distribution of events in a catalog is often complicated by the diffuseness of the earthquake locations. Here, we explore a number of strategies to reduce this diffuseness and hence simplify the seismicity pattern of an earthquake catalog. These strategies utilize information about event locations contained in their overall catalog distribution. They apply this distribution as an a priori constraint on relocations of the events, or as an attractor for each individual event in a collapsing scheme, and thereby focus the locations. The latter strategy is not a relocation strategy in a strict sense, although event foci are moved, because the movements are not driven by data misfit. Both strategies simplify the seismicity pattern of the catalog and may help to interpret it. A synthetic example and a real-data example from an aftershock sequence in south west Iceland are presented to demonstrate application of the strategies. Entropy is used to quantify their effect.

Effects of Unit Design on Acute Care Nurses' Walking Distances, Energy Expenditure, and Job Satisfaction: A Pre-Post Relocation Study.

Science.gov (United States)

Copeland, Darcy; Chambers, Misty

2017-07-01

The purpose of this study was to determine what differences occurred in steps taken and energy expenditure among acute care nurses when their work environment moved from a hospital with centralized nurses' stations to a hospital with decentralized nurses' stations. Additional goals were to determine design features nurses perceived as contributing to or deterring from their work activities and what changes occurred in reported job satisfaction. Since design features can also affect patient outcomes, patient falls were monitored. The construction of a replacement facility for a 224-bed Level 1 trauma center provided the opportunity to compare the effects of centralized versus decentralized nurses' stations on nurses' experiences of their work environments. A pre-post quasi-experimental design was used. RN participants completed an open-ended questionnaire and recorded pedometer data at the end of each shift, working for 3-month pre-relocation and for 3-month post-relocation. Nine months passed between the move and post-relocation data collection. There were significant reductions in nurses' energy expenditure ( p job satisfaction was high and improved post-relocation, and patient falls decreased by 55%. Post-relocation, a number of the dissatisfiers associated with the physical environment were eliminated, and nurses identified more satisfiers (in general and related to the physical environment). Patients are safer post-relocation as indicated by a decrease in falls. This decrease is even more noteworthy when considering that the numbers of patient beds on each unit is higher post-relocation.

Burnout Syndrome of Leisure Time Activities Specialist.

OpenAIRE

REBROVÁ, Iveta

2012-01-01

This thesis is dealing with burnout syndrome among leisure time specialists. Theoretical part describes burnout syndrome, its historical basis, symptoms and causes, protective factors and preventive techniques, which prevent from burnout syndrome risk. Next part deals with common stress, its causes and symptoms, and psychosocial stress, which is closely related with burnout syndrome. Ending of the theoretical part is focused on understanding the differences between jobs of common teacher and ...

Food Relocalization for Environmental Sustainability in Cumbria

Directory of Open Access Journals (Sweden)

Les Levidow

2011-04-01

Full Text Available In the past decade, many European farmers have adopted less-intensive production methods replacing external inputs with local resources and farmers’ skills. Some have developed closer relations with consumers, also known as short food-supply chains or agro-food relocalization. Through both these means, farmers can gain more of the value that they have added to food production, as well as greater incentives for more sustainable methods and/or quality products, thus linking environmental and economic sustainability. These systemic changes encounter difficulties indicating two generic needs—for state support measures, and for larger intermediaries to expand local markets. The UK rural county of Cumbria provides a case study for exploring those two needs. Cumbria farmers have developed greater proximity to consumers, as a means to gain their support for organic, territorially branded and/or simply ‘local’ food. This opportunity has been an incentive for practices which reduce transport distances, energy costs and other inputs. Regional authorities have provided various support measures for more closely linking producers with each other and with consumers, together developing a Cumbrian food culture. Going beyond the capacity of individual producers, farmer-led intermediaries have maintained distinctive product identities in larger markets including supermarket chains. Although Cumbria’s agro-food relocalization initiatives remain marginal, they counteract the 1990s trend towards delocalization, while also indicating potential for expansion elsewhere.

Stress, Locus of Control, and Family Cohesion and Adaptability in Parents of Children with Down, Williams, Fragile X, and Prader-Willi Syndromes

Science.gov (United States)

Lanfranchi, Silvia; Vianello, Renzo

2012-01-01

The present study analyzes differences in parental stress in families of children with Down, Williams, Fragile X, and Prader-Willi syndromes, exploring factors that influence parental stress, such as child's characteristics, parental locus of control, and family cohesion and adaptability. Differences between mothers and fathers are also…

Psychological distress and stressful life events in pediatric complex regional pain syndrome

Science.gov (United States)

Wager, Julia; Brehmer, Hannah; Hirschfeld, Gerrit; Zernikow, Boris

2015-01-01

BACKGROUND: There is little knowledge regarding the association between psychological factors and complex regional pain syndrome (CRPS) in children. Specifically, it is not known which factors precipitate CRPS and which result from the ongoing painful disease. OBJECTIVES: To examine symptoms of depression and anxiety as well as the experience of stressful life events in children with CRPS compared with children with chronic primary headaches and functional abdominal pain. METHODS: A retrospective chart study examined children with CRPS (n=37) who received intensive inpatient pain treatment between 2004 and 2010. They were compared with two control groups (chronic primary headaches and functional abdominal pain; each n=37), who also received intensive inpatient pain treatment. Control groups were matched with the CRPS group with regard to admission date, age and sex. Groups were compared on symptoms of depression and anxiety as well as stressful life events. RESULTS: Children with CRPS reported lower anxiety and depression scores compared with children with abdominal pain. A higher number of stressful life events before and after the onset of the pain condition was observed for children with CRPS. CONCLUSIONS: Children with CRPS are not particularly prone to symptoms of anxiety or depression. Importantly, children with CRPS experienced more stressful life events than children with chronic headaches or abdominal pain. Prospective long-term studies are needed to further explore the potential role of stressful life events in the etiology of CRPS. PMID:26035287

Relationships between inflammation, adiponectin, and oxidative stress in metabolic syndrome.

Directory of Open Access Journals (Sweden)

Shu-Ju Chen

Full Text Available Metabolic syndrome (MS represents a cluster of physiological and anthropometric abnormalities. The purpose of this study was to investigate the relationships between the levels of inflammation, adiponectin, and oxidative stress in subjects with MS. The inclusion criteria for MS, according to the Taiwan Bureau of Health Promotion, Department of Health, were applied to the case group (n = 72. The control group (n = 105 comprised healthy individuals with normal blood biochemical values. The levels of inflammatory markers [high sensitivity C-reactive protein (hs-CRP and interleukin-6 (IL-6, adiponectin, an oxidative stress marker (malondialdehyde, and antioxidant enzymes activities [catalase (CAT, superoxide dismutase (SOD, and glutathione peroxidase (GPx] were measured. Subjects with MS had significantly higher concentrations of inflammatory markers and lower adiponectin level, and lower antioxidant enzymes activities than the control subjects. The levels of inflammatory markers and adiponectin were significantly correlated with the components of MS. The level of hs-CRP was significantly correlated with the oxidative stress marker. The IL-6 level was significantly correlated with the SOD and GPx activities, and the adiponectin level was significantly correlated with the GPx activity. A higher level of hs-CRP (≥1.00 mg/L, or IL-6 (≥1.50 pg/mL or a lower level of adiponectin (<7.90 µg/mL were associated with a significantly greater risk of MS. In conclusion, subjects suffering from MS may have a higher inflammation status and a higher level of oxidative stress. A higher inflammation status was significantly correlated with decreases in the levels of antioxidant enzymes and adiponectin and an increase in the risk of MS.

Heat transfer between relocated materials and the RPV lower head

Energy Technology Data Exchange (ETDEWEB)

Rempe, J.L.; Knudson, D.L. [Idaho National Engineering and Environmental Lab., Idaho Falls, ID (United States); Kohriyama, T. [INSS, Fukui (Japan)

2001-07-01

Questions about the coolability of a continuous mass of relocated corium were raised during the Three Mile Island Unit 2 (TMI-2) Vessel Investigation Project (VIP) Post-accident examinations indicate that nearly half of the material that relocated to the vessel lower head during the TMI-2 accident formed a cohesive or ''continuous'' layer. TMI-2 VIP results and other evidence suggest that conduction through this continuous layer of solidified corium materials was assisted by other cooling mechanisms. Because increased knowledge about in-vessel coolability of corium materials may assist reactor designers in demonstrating that their concepts are passively safe, there is international interest in this topic. However, data are needed to identify what cooling mechanism(s) occurred and to develop a validated model for predicting this cooling. Corium cooling models significantly impact predictions for subsequent accident progression, such as the estimated time and mode of vessel failure. Hence, improved cooling models will provide a much needed, missing component of severe accident analyses. This paper provides a critical review of research investigating the coolability of corium relocating to a water-filled lower head. Where possible, existing models and data for predicting cooling are quantitatively compared; and governing relationships are identified. Key phenomena that should be incorporated into models for predicting this heat transfer are discussed, and deficiencies in current models and available data for predicting cooling are noted. Recommendations for improving these models and for obtaining data to validate these models are also provided. (author)

Subnuclear relocalization and silencing of a chromosomal region by an ectopic ribosomal DNA repeat

DEFF Research Database (Denmark)

Jakociunas, Tadas; Domange Jordö, Marie Elise; Mebarek, Mazhoura Aït

2013-01-01

Our research addresses the relationship between subnuclear localization and gene expression in fission yeast. We observed the relocalization of a heterochromatic region, the mating-type region, from its natural location at the spindle-pole body to the immediate vicinity of the nucleolus. Relocali......Our research addresses the relationship between subnuclear localization and gene expression in fission yeast. We observed the relocalization of a heterochromatic region, the mating-type region, from its natural location at the spindle-pole body to the immediate vicinity of the nucleolus...

The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans

Directory of Open Access Journals (Sweden)

Hauger Richard L

2009-01-01

Full Text Available Abstract Background There is accumulating evidence for a link between trauma exposure, posttraumatic stress disorder (PTSD and diminished health status. To assess PTSD-related biological burden, we measured biological factors that comprise metabolic syndrome, an important established predictor of morbidity and mortality, as a correlate of long-term health risk in PTSD. Methods We analyzed clinical data from 253 male and female veterans, corresponding to five factors linked to metabolic syndrome (systolic and diastolic blood pressure, waist-to-hip ratio and fasting measures of high-density lipoprotein (HDL cholesterol, serum triglycerides and plasma glucose concentration. Clinical cut-offs were defined for each biological parameter based on recommendations from the World Health Organization and the National Cholesterol Education Program. Controlling for relevant variables including sociodemographic variables, alcohol/substance/nicotine use and depression, we examined the impact of PTSD on metabolic syndrome using a logistic regression model. Results Two-fifths (40% of the sample met criteria for metabolic syndrome. Of those with PTSD (n = 139, 43% met criteria for metabolic syndrome. The model predicted metabolic syndrome well (-2 log likelihood = 316.650, chi-squared = 23.731, p = 0.005. Veterans with higher severity of PTSD were more likely to meet diagnostic criteria for metabolic syndrome (Wald = 4.76, p = 0.03. Conclusion These findings provide preliminary evidence linking higher severity of PTSD with risk factors for diminished health and increased morbidity, as represented by metabolic syndrome.

Exploring the impact of residential relocation on modal shift in commute trips : Evidence from a quasi-longitudinal analysis

NARCIS (Netherlands)

Yang, M.; Wu, J.; Rasouli, S.; Cirillo, C.; Li, D.

2017-01-01

A growing number of studies have been devoted to the effects of residential relocation on travel behavior. However, most of these studies only focus on the direct effects of personal and system characteristics; while, residential relocation may trigger several interrelated changes in activity-travel

41 CFR 302-12.100 - What are “relocation services”?

Science.gov (United States)

2010-07-01

... marketing assistance, home finding assistance, and property management services. ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What are ârelocation servicesâ? 302-12.100 Section 302-12.100 Public Contracts and Property Management Federal Travel Regulation...

Aetiology and mechanisms of injury in medial tibial stress syndrome: Current and future developments

OpenAIRE

Franklyn, Melanie; Oakes, Barry

2015-01-01

Medial tibial stress syndrome (MTSS) is a debilitating overuse injury of the tibia sustained by individuals who perform recurrent impact exercise such as athletes and military recruits. Characterised by diffuse tibial anteromedial or posteromedial surface subcutaneous periostitis, in most cases it is also an injury involving underlying cortical bone microtrauma, although it is not clear if the soft tissue or cortical bone reaction occurs first. Nuclear bone scans and magnetic resonance imagin...

Fathers of children with Down's syndrome versus other types of intellectual disability: perceptions, stress and involvement.

Science.gov (United States)

Ricci, L A; Hodapp, R M

2003-01-01

The present study examined fathers' perceptions of, stress relating to and involvement with children with Down's syndrome (DS) (n = 30) versus those with other types of intellectual disability (ID) (n = 20). Fathers and mothers completed questionnaires about their children's personalities and maladaptive behaviours, their own parenting stress, and the fathers' level of involvement. Both fathers and mothers rated their children with DS as having more positive personality traits and fewer maladaptive behaviours. Possibly because of these positive perceptions, fathers of children with DS also reported less child-related stress, particularly in the areas of acceptability, adaptability and demandingness. The two groups of fathers were very similarly involved in child rearing. The personality, age and maladaptive behaviours of the children related to stress levels in the fathers of children with DS, while maladaptive behaviours, gender and the fathers' education levels related to stress levels in the fathers of children with other types of ID. These results highlight the importance of examining parental stress and involvement with children with different types of ID.

[The role of stress-induced chronic subclinical inflammation in the pathogenesis of the chronic pelvic pain syndrome IIIB in men].

Science.gov (United States)

Shormanov, I S; Mozhaev, I I; Sokolova, Kh A; Solovev, A S

2017-12-01

This literature review of recent clinical and experimental studies describes the role of oxidative stress in the multifactorial and interdisciplinary pathogenesis of non-inflammatory chronic pelvic pain syndrome IIIB (CPPS-IIIB) in men. The authors outline general biological nature of oxidative stress and its mechanisms. More detailed information is presented on cytokine-mediated chronic subclinical inflammation, one of the key mechanisms of oxidative stress, which is currently being actively studied. It is shown that the imbalance between pro- and anti-inflammatory cytokines observed in patients with CPPS-IIIB can explain some features of the clinical course (in particular, the characteristics of the pain syndrome) and the progression of this disease. In this regard, cytokine profiling of prostatic secretion can provide valuable diagnostic, prognostic and monitoring information in the management of this category of patients. Recently published evidence has demonstrated the essential role of the cytokine-mediated chronic inflammatory response as a mechanism of oxidative stress in the pathogenesis of CPPS-IIIB. Further studies in this area are warranted and in the long term may become a basis for the development of new effective pathogenetic pharmacotherapy of CPPS-IIIB.

Associations of biochemical changes and maternal traits with mutation 1843 (C>T in the RYR1 gene as a common cause for porcine stress syndrome

Directory of Open Access Journals (Sweden)

Popovski ZT

2016-12-01

Full Text Available Stress syndrome is usually caused by a mutation in the ryanodine receptor gene (ryr1 and it is widely studied in humans and swine populations. The protein product of this gene plays a crucial role in the regulation of calcium transport in muscle cells. A G>T mutation in the human ryr1 gene, which results in the replacement of a conserved arginine at position 614 where a leucine occurs at the same position as the previously identified Arg→Cys mutation reported in all cases of porcine stress syndrome (PSS. Porcine stress syndrome affects biochemical pathways in stress-susceptible individuals during a stress episode and some biochemical parameters that were used as markers for diagnostic purposes. Also, PSS has remarkable influence on the maternal characteristics of sows. This study dealt with different genotypes for PSS and its association with possible biochemical changes and maternal traits of sows. Seventy-three reproductive sows genotyped for PSS by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP were included in this survey. Sixty of them were stress-free (NN, 11 were heterozygous carriers (Nn and two animals were homozygous (nn for the 1843 (C>T mutation. Significant differences in non stress induced animals with different PSS genotypes were found in the values of creatine phoshokinase (CPK, lactate dehydrogenase (LDH, alkaline phosphatase (AP and aspartate aminotransferase (AST. Regarding the maternal traits, our study showed that stress susceptible animals (nn have an increased number of stillborn piglets and a reduced number of newborn piglets compared with heterozygous and normal animals.

Seismicity studies at Moluccas area based on the result of hypocenter relocation using HypoDD

Energy Technology Data Exchange (ETDEWEB)

Utama, Muhammad Reza July, E-mail: muhammad.reza@bmkg.go.id [Student of Geophysical Engineering Study Program, Institute of Technology Bandung (Indonesia); Indonesian Meteorological, Climatological and Geophysical Agency (MCGA), Jakarta (Indonesia); Nugraha, Andri Dian; Puspito, Nanang T. [Global Geophysical Research Group, Faculty of Mining and Petroleum Engineering, ITB (Indonesia)

2015-04-24

The precise hypocenter was determined location using double difference method around subduction zone in Moluccas area eastern part of Indonesia. The initial hypocenter location from MCGA data catalogue of 1,945 earthquake events. Basically the principle of double-difference algorithm assumes if the distance between two earthquake hypocenter distribution is very small compared to the distance between the station to the earthquake source, the ray path can be considered close to both earthquakes. The results show the initial earthquakes with a certain depth (fix depth 10 km) relocated and can be interpreted more reliable in term of seismicity and geological setting. The relocation of the intra slab earthquakes beneath Banda Arc are also clearly observed down to depth of about 400 km. The precise relocated hypocenter will give invaluable seismicity information for other seismological and tectonic studies especially for seismic hazard analysis in this region.

Chronic psychological stress seems associated with elements of the metabolic syndrome in patients with ischaemic heart disease

DEFF Research Database (Denmark)

Bergmann, Natasha; Ballegaard, Søren; Krogh, Jesper

2017-01-01

at the sternum known to be associated to elements of the chronic stress syndrome. Elements of MS were evaluated by dual-energy X-ray absorptiometry, body weight, HOMA-IR and blood lipids. Results: Depressive symptoms were associated with a high percentage of body fat (β = 0.179, p =.001), and high level...

The experience of relocation for specialist treatment for Indigenous women diagnosed with vulvar cancer in East Arnhem Land.

Science.gov (United States)

McGrath, Pam; Rawson, Nicole

2013-01-01

Vulvar cancer is a serious condition that requires a range of specialist treatments including surgery, chemotherapy, and radiation. In Australia, such treatments are only available in major metropolitan hospitals. Thus, women diagnosed with this condition in rural and remote areas must relocate to the metropolitan specialist centers for treatment. The focus of this article is on the experience of relocation for specialist care for Indigenous women diagnosed with vulvar cancer from East Arnhem Land, Northern Territory, Australia. The findings presented in this article explore a range of issues that affect the experience of relocation such as community concerns, cultural distress, loneliness, fear, worry, and physical concerns associated with the condition.

Conceptual design for relocation of the underground monitoring systems to ground surface

International Nuclear Information System (INIS)

Toya, Naruhisa; Ogawa, Ken; Iwatsuki, Teruki; Ohnuki, Kenji

2015-09-01

One of the major subjects of the ongoing geoscientific research program, the Mizunami Underground Research Laboratory (MIU) Project in the Tono area, central Japan, is accumulation of knowledge on a recovery of the geological environment during and after the facility closure. Then it is necessary to plan the observation system which can be use of after the backfill of research tunnels. The main purpose of this report is contribution to the detailed design for relocation of the underground monitoring systems to ground surface. We discussed the restriction and requirement for the underground monitoring systems which can be use of after the backfill. Furthermore, we made the conceptual design for relocation of the current underground monitoring systems to ground surface. (author)

Seismicity of the North of the Russian Plate: Relocation of Recent Earthquakese

Science.gov (United States)

Morozov, A. N.; Vaganova, N. V.; Asming, V. E.; Mikhailova, Ya. A.

2018-03-01

The hypocenters of the earthquakes recorded in the north of the Russian Plate from 1982 to 2013 are relocated. The relocation of the hypocenters is based on the common velocity section, common methodology, and the entire set of the initial data and bulletins available from the Russian and foreign seismic stations. The efficiency of the algorithm for calculating the hypocentral parameters and the velocity section is demonstrated by the example of two nonmilitary nuclear explosions in July 18, 1985 and September 6, 1988 in the northern part of the European Russia. For the first time, two earthquakes of July 19, 1982 and October 7, 2012, which have not been previously reported in the catalogs for the north of the Russian plate, are included in the seismic catalog.

78 FR 4134 - Notice of Intent To Prepare An Environmental Impact Statement (EIS) On the Proposal To Relocate...

Science.gov (United States)

2013-01-18

... Proposal To Relocate the 18th Aggressor Squadron From Eielson Air Force Base (EAFB), Alaska to Joint Base... Eielson AFB, AK AGENCY: Pacific Air Forces, United States Air Force, DOD. ACTION: Notice of Intent... Statement (EIS) considering a proposal to relocate the 18th Aggressor Squadron from Eielson AFB to Joint...

Environmental Assessment: Relocation and storage of TRIGA reg-sign reactor fuel, Hanford Site, Richland, Washington

International Nuclear Information System (INIS)

1995-08-01

In order to allow the shutdown of the Hanford 308 Building in the 300 Area, it is proposed to relocate fuel assemblies (101 irradiated, three unirradiated) from the Mark I TRIGA Reactor storage pool. The irradiated fuel assemblies would be stored in casks in the Interim Storage Area in the Hanford 400 Area; the three unirradiated ones would be transferred to another TRIGA reactor. The relocation is not expected to change the offsite exposure from all Hanford Site 300 and 400 Area operations

Effects of an expressive writing intervention on a group of public employees subjected to work relocation.

Science.gov (United States)

Tarquini, Matteo; Di Trani, Michela; Solano, Luigi

2016-02-15

Pennebaker's writing technique has yielded good results on health, psychological and performance dimensions. In spite of the positive outcomes, the technique has rarely been applied directly within the workplace and its effects on burnout have never been tested. 18 public employees subjected to work relocation were asked to write about their present work situation or another difficult event of their life (Writing Group), while another 17 were not assigned any writing task (Control Group). To assess whether there was an improvement in burnout, alexithymia and psychological well-being in the Writing Group compared with the baseline measurement and the Control Group. While the baseline levels in the Writing and Control Groups in the 3 dimensions considered were similar, scores in the Writing Group at both a second (1 month after the end of the procedure) and third measurement (7 months after the end) improved when compared with the baseline, whereas those in the Control Group worsened. Pennebaker's writing technique appears to promote adaptive coping strategies in stressful situations, and to increase occupational and psychological well-being as well as the ability to process emotions. It also appears to buffer the negative effects of work-related stress.

Retinol, β-carotene and oxidative stress in systemic inflammatory response syndrome

Directory of Open Access Journals (Sweden)

Carla Nogueira

2015-04-01

Full Text Available Objective: patients suffering systemic inflammatory response syndrome (SIRS constitute a group susceptible to elevated levels of oxidative stress. This study’s aim is to evaluate the state of oxidative stress and levels of serum retinol and β-carotene in these patients. Methods: forty-six patients were divided into 2 groups: those those without diet (G1; n=18 and those with enteral nutritional support (G2; n=28. Serum levels of retinol and total carotenoids were measured. C-reactive protein (CRP levels and Apache scores were also calculated. Oxidative stress was estimated by measuring thiobarbituric acid reactive substance (TBARS levels. Results: the patients’ median age was 66.9 (SD=19.3 years. Lower concentrations of retinol and carotenoids were found in 68.6 and 66.7% of G1, respectively. In G2, despite average vitamin A levels being 8078 + 4035, retinol and β-carotene were considered insufficient (31.2 and 33.4%, respectively. No difference was noted between the 2 groups, according to the variables studied, with the exception being PCR and β-carotene (p=0.002; p=0.01. Conclusion: the data presented in this study supports the need to establish/revise clinical practices in treating SIRS patients, in light of this micronutrient’s role in the immune system and antioxidant defense without it interfering with its toxicity.

Parenting a child at home with hypoplastic left heart syndrome: experiences of commitment, of stress, and of love.

Science.gov (United States)

Cantwell-Bartl, Annie M; Tibballs, James

2017-09-01

To evaluate the experiences of parenting a child with hypoplastic left heart syndrome after the child has been discharged home from hospital. A study of the parents' experiences using face-to-face interviews and psychometric measures with parents whose child had survived stage surgery. Parents were interviewed within the home environment or within the hospital if that was their choice. A total of 29 parents (16 mothers and 13 fathers) of surviving children. Intervention A semi-structured face-to-face interview plus psychometric tests (parent demographics, Maslach Burnout Inventory, Impact on Family Scale, and the Psychological Check List - Civilian). Measurements and main results The parents' experience in supporting a child with hypoplastic left heart syndrome is one of stress, of commitment, and of love. Although parents experienced joy in their child, they were also subjected to anxiety with four parents test positive to post-traumatic stress disorder and hypervigilance while monitoring their child's condition. Parents lived with many difficulties, and demands.

Technical committee meeting on material-coolant interactions and material movement and relocation in liquid metal fast reactors

International Nuclear Information System (INIS)

1994-01-01

The Technical Committee Meeting on Material-Coolant Interactions and Material Movement and Relocation in Liquid Metal Fast Reactors was sponsored by the International Working Group on Fast Reactors (IWGFR), International Atomic Energy Agency (IAEA) and hosted by PNC, on behalf of the Japanese government. A broad range of technical subjects was discussed in the TCM, covering entire aspects of material motion and interactions relevant to the safety of LMFRs. Recent achievement and current status in research and development in this area were presented including European out-of-pile test of molten material movement and relocation; molten material-sodium interaction; molten fuel-coolant interaction; core disruptive accidents; sodium boiling; post accident material relocation, heat removal and relevant experiments already performed or planned

Technical committee meeting on material-coolant interactions and material movement and relocation in liquid metal fast reactors

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-07-01

The Technical Committee Meeting on Material-Coolant Interactions and Material Movement and Relocation in Liquid Metal Fast Reactors was sponsored by the International Working Group on Fast Reactors (IWGFR), International Atomic Energy Agency (IAEA) and hosted by PNC, on behalf of the Japanese government. A broad range of technical subjects was discussed in the TCM, covering entire aspects of material motion and interactions relevant to the safety of LMFRs. Recent achievement and current status in research and development in this area were presented including European out-of-pile test of molten material movement and relocation; molten material-sodium interaction; molten fuel-coolant interaction; core disruptive accidents; sodium boiling; post accident material relocation, heat removal and relevant experiments already performed or planned.

Structural Responses of a Stream Community to a Channel Relocation Using a Natural Channel Design Approach

Science.gov (United States)

Jack, J.; Word, D.; Daniel, W.; Pritchard, S.; Parola, A.; Vesely, B.

2005-05-01

Streams have been heavily impacted by historical and contemporary management practices. Restorations are seen as a way to enhance stream ecosystem integrity, but there are few restoration sites where pre- and post-restoration data are available to assess "success." In 2003, a channelized reach of Wilson Creek (Kentucky, USA) was relocated using a natural channel design approach. We compared the structural and functional responses of the stream pre- and post restoration/relocation at sites within Wilson and two reference streams. Despite the construction disturbance, water chemistry parameters such as nitrate and turbidity were nearly identical at sampling stations above and below the relocation for 2003-2004. Macroinvertebrate colonization of the relocation sites was rapid, with communities dominated by Cheumatopsyche, Perlesta and Baetis. Assessments of CPOM transport indicated that the new stream channel is more retentive of leaf and woody debris material than the pre-restoration Wilson sites or unrestored reference stream sites. The restoration of suitable habitat and the presence of "source populations" for colonization may compensate for even large-scale (but short-term) construction disturbance. More research is needed to assess the balance between the disturbance impacts of restoration installation and the long term benefits of stream ecological improvement.

Business or Pleasure? Blurring Relocation Categories and Motivation Patterns among Expatriates

DEFF Research Database (Denmark)

Lauring, Jakob; Selmer, Jan; Kristian S. Jacobsen, Jens

2014-01-01

and relations between leisure tourism and international work relocations. The study uniquely examines demographic differences in tourism and work motivation of academics temporarily residing abroad. Data was collected from 428 self-initiated expatriate academics from 60 countries temporarily working at 34...

Thermal and stress analyses of the reactor pressure vessel lower head of the Three Mile Island Unit 2

International Nuclear Information System (INIS)

Hashimoto, K.; Onizawa, K.; Kurihara, R.; Kawasaki, S.; Soda, K.

1992-01-01

Thermal and stress analyses were performed using the finite element analysis code ABAQUS to clarify the factors which caused tears in the stainless steel liner of the reactor pressure vessel lower head of the Three Mile Island Unit 2 (TMI-2) reactor pressure vessel during the accident on 28 March 1979. The present analyses covered the events which occurred after approximately 20 tons of molten core material were relocated to the lower head of the reactor pressure vessel. They showed that the tensile stress was highest in the case where the relocated core material consisting of homogeneous UO 2 debris was assumed to attack the lower head and the debris was then quenched. The peak tensile stress was in the vicinity of the welded zone of the penetration nozzle. This result agrees with the findings from the examination of the TMI-2 reactor pressure vessel that major tears in the stainless steel liner were observed around two penetration nozzles of the lower head. (author)

Mechanism analysis on nuclear technical relocation of the major countries

International Nuclear Information System (INIS)

1985-12-01

This report is about cooperation method of nuclear energy among the USA, France and Canada. So it deals with building a cooperative system on nuclear technical relocation, researching a foreign policy on nuclear energy of the USA and cooperation method and cooperation trend of Japan, Canada, Russia, China and West Germany.

Stress and the Microbiota-Gut-Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome.

Science.gov (United States)

Moloney, Rachel D; Johnson, Anthony C; O'Mahony, Siobhain M; Dinan, Timothy G; Greenwood-Van Meerveld, Beverley; Cryan, John F

2016-02-01

Visceral pain is a global term used to describe pain originating from the internal organs of the body, which affects a significant proportion of the population and is a common feature of functional gastrointestinal disorders (FGIDs) such as irritable bowel syndrome (IBS). While IBS is multifactorial, with no single etiology to completely explain the disorder, many patients also experience comorbid behavioral disorders, such as anxiety or depression; thus, IBS is described as a disorder of the gut-brain axis. Stress is implicated in the development and exacerbation of visceral pain disorders. Chronic stress can modify central pain circuitry, as well as change motility and permeability throughout the gastrointestinal (GI) tract. More recently, the role of the gut microbiota in the bidirectional communication along the gut-brain axis, and subsequent changes in behavior, has emerged. Thus, stress and the gut microbiota can interact through complementary or opposing factors to influence visceral nociceptive behaviors. This review will highlight the evidence by which stress and the gut microbiota interact in the regulation of visceral nociception. We will focus on the influence of stress on the microbiota and the mechanisms by which microbiota can affect the stress response and behavioral outcomes with an emphasis on visceral pain. © 2015 John Wiley & Sons Ltd.

A Nucleocytoplasmic Shuttling Protein in Oxidative Stress Tolerance

Energy Technology Data Exchange (ETDEWEB)

Ow, David W.; Song, Wen

2003-03-26

Plants for effective extraction of toxic metals and radionuclides must tolerate oxidative stress. To identify genes that enhance oxidative stress tolerance, an S. pombe cDNA expression plasmid library was screened for the ability to yield hypertolerant colonies. Here, we report on the properties of one gene that confers hypertolerance to cadmium and oxidizing chemicals. This gene appears to be conserved in other organisms as homologous genes are found in human, mouse, fruitfly and Arabidopsis. The fruitfly and Arabidopsis genes likewise enhance oxidative stress tolerance in fission yeast. During oxidative stress, the amount of mRNA does not change, but protein fusions to GFP relocate from the cytoplasm to the nucleus. The same pattern is observed with the Arabidopsis homologue-GFP fusion protein. This behavior suggests a signaling role in oxidative stress tolerance and these conserved proteins may be targets for engineering stress tolerant plants for phytoremediation.

41 CFR 302-12.9 - What are the income tax consequences if I use a relocation services company?

Science.gov (United States)

2010-07-01

... the income tax consequences if I use a relocation services company? You may incur income taxes on... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What are the income tax consequences if I use a relocation services company? 302-12.9 Section 302-12.9 Public Contracts and Property...

75 FR 24740 - Recovery Fact Sheet RP9580.102, Permanent Relocation

Science.gov (United States)

2010-05-05

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2010-0028] Recovery Fact Sheet RP9580.102, Permanent Relocation AGENCY: Federal Emergency Management Agency, DHS... Management Agency (FEMA). DATES: This fact sheet is effective April 14, 2010. ADDRESSES: This final fact...

The effect of ewes relocation on milk composition and milk flow kinetics

Directory of Open Access Journals (Sweden)

Lucia Jackuliaková

2014-02-01

Full Text Available The investigation of an influence of ewes relocation and milking in other parlour (treatment on milk flow kinetics, milkability and milk composition was the aim of this study. In total 34 ewes of two breeds and crosbreeds Tsigai (14 heads and Improved Valachian (20 heads with Lacaune were tested. Two weeks after lamb weaning the ewes were milked in parallel milking parlour (1x16 stalls under shelter. On the last evening milking (first experimental milking, EB before relocation of flock to another parlour, and during next three continuous evening milkings (E0 - second, E1 - third and E2 - fourth milking of exp. after relocation the milk flow kinetics were measured using electronic collection jar. On day E0 after morning milking the flock was moved on a pasture and milked in other parlour (1x24-stalls. During E0 we recorded a significant decrease of total milk yield in comparison with EB (0.527 ±0.04 and 0.647 ±0.04 L. Significant differences were also recorded in machine milk yield, machine stripping, milking time and in maximum milk flow rate. During E0 there was a higher number of nonbimodal and lower numbers of bimodal flow types. The response of ewe to E0 depended on its response to EB. Ewes with bimodal flow at EB responded more negatively to E0 than ewes with nonbimodal or plateau flow. During E2 there were significantly increased protein content and solids not fat in milk. Thus the treatment significantly influenced the milkability of ewes in a negative way, but more clear response was found out in ewes with bimodal flow response to machine milking before treatment. We could assume that relocation to other milking conditions caused only short-term changes in milk flow kinetic and milk yield. Normal 0 21 false false false SK X-NONE X-NONE

Microearthquake Study of the Salton Sea Geothermal Field, California: Evidence of Stress Triggering

International Nuclear Information System (INIS)

Holland, Austin A.

2002-01-01

A digital network of 24 seismograph stations was operated from September 15, 1987 to September 30, 1988, by Lawrence Livermore National Laboratory and Unocal as part of the Salton Sea Scientific Drilling Project to study seismicity related to tectonics and geothermal activity near the drilling site. More than 2001 microearthquakes were relocated in this study in order to image any pervasive structures that may exist within the Salton Sea geothermal field. First, detailed velocity models were obtained through standard 1-D inversion techniques. These velocity models were then used to relocate events using both single event methods and Double-Differencing, a joint hypocenter location method. An anisotropic velocity model was built from anisotropy estimates obtained from well logs within the study area. During the study period, the Superstition Hills sequence occurred with two moderate earthquakes of MS 6.2 and MS 6.6. These moderate earthquakes caused a rotation of the stress field as observed from the inversion of first motion data from microearthquakes at the Salton Sea geothermal field. Coulomb failure analysis also indicates that microearthquakes occurring after the Superstition Hills sequence are located within a region of stress increase suggesting stress triggering caused by the moderate earthquakes

Perceived Stress, Its Physiological Correlates, and Quality of Life in Patients With Irritable Bowel Syndrome.

Science.gov (United States)

Weaver, Kristen R; Melkus, Gail D'Eramo; Fletcher, Jason; Henderson, Wendy A

2018-05-01

Irritable bowel syndrome (IBS) is a chronic, common disorder of the gastrointestinal tract associated with high psychological comorbidity and diminished quality of life. Patients with IBS display a heightened sensitivity to stress, although the literature is inconsistent as to whether they have a dysregulated stress response. The purpose of the present investigation, a substudy of a larger research effort, was to examine physiological correlates of perceived stress in patients with IBS (cortisol and adrenocorticotropic hormone) and to explore associations between perceived stress and quality of life. A total of 101 participants (35 with IBS [predominant subtypes IBS-constipation and IBS-diarrhea] and 66 healthy controls [HCs]) completed self-report inventories regarding perceived stress and quality of life, and fasting peripheral blood was drawn. Participants with IBS did not differ from the HC in demographic or physiological measures but did differ in psychological measures, reporting significantly higher levels of perceived stress and lower levels of quality of life. Perceived stress and quality of life were not significantly associated in IBS participants. However, differential findings of the stress response were found within IBS participants by sex, race, and subtype. These findings illustrate the heterogeneity of the IBS patient population, underscore the necessity of evaluating larger sample sizes and increasing the diversity of such samples to include males and ethnic minorities, and demonstrate the importance of taking an individualized approach to evaluation and treatment in the IBS patient population.

[Stress syndrome in patients receiving outpatient treatment at the General Hospital, in Bangui, in a context of armed conflict].

Science.gov (United States)

Mpembi, Magloire Nkosi; Lukeba, Thierry; Mayemba, Damien; Massamba, Victoria Kubuta; Ma Nzuzi, Thierry Matonda; Gokara, Symphorien; Vermeiren, Etienne; Mananga Lelo, Gilbert; Ma Miezi, Samuel Mampunza

2018-01-01

in Africa's zones of conflict, recent studies report a high frequency of post-traumatic stress disorder (PTSD) particularly in community settings. This study aimed to contribute to a better management of patients experiencing violence subsequent to the Central African Republic socio-political conflict. We conducted a cross-sectional study of the medical records of patients receiving outpatient treatment in the Doctors Without Borders/Médecins Sans Frontières (France) Trauma Center, Bangui. 33.33% (n=35) of patients had PTSD, while 17.14% (n=18) of patients had acute stress syndrome. Stress syndrome (SS) was associated with female sex, rape, anxiety and depression. Rape multiplied the risk of SS occurrence by 8. The average age was 30 years (P25:22 years; P75:40 years). The majority of patients had mood disorder (63.81%; n=67). Insomnia was present in 62.83% (n=66) of patients. Hospital Anxiety and Depression Scale (HADS) was present in 44.76 % of patients. Depression was found in 40.95% (n=43) of patients. The obtained results show how the society, apart from militia members, is affected by conflict-related violence in the country. These results can enrich the reflections on health organisation and on the management of patients in Central African, by considering the impact of conflict-related acute stress syndome in the short, medium and long term.

Survival of the relocated population of the U. S. after a nuclear attack. Final report

Energy Technology Data Exchange (ETDEWEB)

Haaland, C.M.; Chester, C.V.; Wigner, E.P.

1976-06-01

The feasibility of continued survival after a hypothetical nuclear attack is evaluated for people relocated from high-risk areas during the crisis period before the attack. The attack consists of 6559 MT, of which 5951 MT are ground bursts on military, industrial, and urban targets. Relocated people are assumed to be adequately protected from fallout radiation by shelters of various kinds. The major problems in the postattack situation will be the control of exposure to fallout radiation, and prevention of severe food shortages to several tens of millions of people.

Wages and commuting: quasi-natural experiments' evidence from firms that relocate

NARCIS (Netherlands)

Mulalic, I.; van Ommeren, J.N.; Pilegaard, N.

2014-01-01

We examine individual-level compensating differentials for commuting distance in a quasi-natural experiment setting by examining how wages respond to changes in commuting distance induced by firm relocations. This set-up enables us to test for the relevance of job search frictions within labour

Oxidative stress and inflammation in lean and obese subjects with polycystic ovary syndrome.

Science.gov (United States)

Blair, Sarah A; Kyaw-Tun, Tommy; Young, Ian S; Phelan, Niamh A; Gibney, James; McEneny, Jane

2013-01-01

To determine whether polycystic ovary syndrome (PCOS) independently influences oxidative stress and inflammation or if the culprit is the comorbidities of obesity and/or insulin resistance common to this condition. Thirty women with PCOS were matched for age, body mass index and insulin resistance with 30 control subjects. Oxidative stress was examined by measuring the total oxidant status (TOS) and total antioxidant capacity (TAC) by spectrophotometric assay. The inflammatory biomarkers, C-reactive protein, plasminogen activator inhibitor-1, myeloperoxidase, neopterin, and serum amyloid A were measured by ELISA methodologies. Oxidative status was increased in the PCOS subjects relative to their weight-matched controls (TOS: obese PCOS patients vs. obese controls, 42.42 +/- 4.49 vs. 32.57 +/- 1.97, plean PCOS patients vs. lean controls, 33.69 +/- 1.59 vs. 28.69 +/- 1.18 micromol H2O2 Equiv/L, p lean PCOS group relative to their weight-matched controls (TAC: lean PCOS patients vs. lean controls, 1.10 +/- 0.09 vs. 1.49 +/- 0.03 nmol Trolox Equiv/L, p PCOS independently influenced oxidative stress. Overall, the presence of PCOS may increase cardiovascular risk.

Data forwarding mechanism for supporting real-time services during relocations in UMTS systems

Science.gov (United States)

Cai, Wei; Liao, Xianglong; Zheng, Liang; Liu, Zehong

2004-04-01

To minimize the interruption during the handovers or relocations invoked by subscribers moving is a very critical factor to enhance the performance of the UMTS systems. We know that the 2G systems have been optimized to minimize the interruption of speech during handovers by two main technologies: one is the bi-casting for the DL traffic and the other is the fast radio resynchronization by the UE for the UL traffic. In the UMTS systems, we have also implemented lossless relocations for non real-time services with high reliability by data buffering in the source RNC and target RNC for the UE. However, the UMTS systems support four QoS classes traffic flow: conversational class, streaming class, interactive class and background class. The main distinguishing factor between these QoS classes is how delay sensitive the traffic is: Conversational and Streaming classes are mainly used to carry real-time traffic flows, like video telephony, interactive and background classes are mainly used by traditional Internet applications like WWW, E-mail and FTP. It"s essential to provide the solutions for supporting real-time services to meet the requirement for QoS in UMTS systems. Apparently, the Data buffering mechanism is not adapted to real-time services because of it"s delay may exceed the basic requirement for real-time services. Under this background, the paper discussed two data forwarding solutions for real-time services from the PS domain in the UMTS systems: packet duplication and Core Network bi-casting. The former mechanism does not require any new procedures, messages nor information elements. The later mechanism requires that the GGSN or SGSN is able to bi-cast the DL traffic to the target RNC according to the relocations involving two SGSNs or just involving one SGSN. It also implicitly shows that we need change procedures at the nodes SGSN, GGSN and RNC which are involved in the relocation procedure based on existing procedures that we have already designed if

Study of Profile Changes during Mechanical Polishing using Relocation Profilometry

Science.gov (United States)

Kumaran, S. Chidambara; Shunmugam, M. S.

2017-10-01

Mechanical polishing is a finishing process practiced conventionally to enhance quality of surface. Surface finish is improved by mechanical cutting action of abrasive particles on work surface. Polishing is complex in nature and research efforts have been focused on understanding the polishing mechanism. Study of changes in profile is a useful method of understanding behavior of the polishing process. Such a study requires tracing same profile at regular process intervals, which is a tedious job. An innovative relocation technique is followed in the present work to study profile changes during mechanical polishing of austenitic stainless steel specimen. Using special locating fixture, micro-indentation mark and cross-correlation technique, the same profile is traced at certain process intervals. Comparison of different parameters of profiles shows the manner in which metal removal takes place in the polishing process. Mass removal during process estimated by the same relocation technique is checked with that obtained using weight measurement. The proposed approach can be extended to other micro/nano finishing processes and favorable process conditions can be identified.

Effects of black bear relocation on elk calf recruitment at Great Smoky Mountains National Park

Science.gov (United States)

Yarkovich, J.; Clark, J.D.; Murrow, J.L.

2011-01-01

Previous research from 2001 to 2006 on an experimentally released elk (Cervus elaphus) population at Great Smoky Mountains National Park (GSMNP or Park) indicated that calf recruitment (i.e., calves reaching 1 yr of age per adult female elk) was low (0.306, total SE = 0.090) resulting in low or negative population growth (λ = 0.996, 95% CI = 0.945–1.047). Black bear (Ursus americanus) predation was the primary calf mortality factor. From 2006 to 2008, we trapped and relocated 49 bears (30 of which were radiocollared) from the primary calving areas in the Park and radiomonitored 67 (28 M:39 F) adult elk and 42 calves to compare vital rates and population growth with the earlier study. A model with annual calf recruitment rate correlating with the number of bears relocated each year was supported (ΔAICc = 0.000; β = 0.070, 95% CI = 0.028–0.112) and a model with annual calf recruitment differing from before to during bear relocation revealed an increase to 0.544 (total SE = 0.098; β = −1.092, 95% CI = −1.180 to −0.375). Using vital rates and estimates of process standard errors observed during our study, 25-yr simulations maintained a mean positive growth rate in 100% of the stochastic trials with λ averaging 1.118 (95% CI = 1.096–1.140), an increase compared with rates before bear relocation. A life table response experiment revealed that increases in population growth were mostly (67.1%) due to changes in calf recruitment. We speculate that behavioral adaptation of the elk since release also contributed to the observed increases in recruitment and population growth. Our results suggest that managers interested in elk reintroduction within bear range should consider bear relocation as a temporary means of increasing calf recruitment.

Brain-hepato-renal syndrome (Zellweger syndrome). Report of two cases and a review of the syndrome

International Nuclear Information System (INIS)

Ruiz, T.; Caparros, C.; Blanco, A.; Lopez, A.M.

1997-01-01

Cerebro-hepato-renal syndrome is a rare disorder that is transmitted by autosomal recessive inheritance. Children with this syndrome present mongoloid facies and severe muscle hypotonic at birth. Scimitar-like knee calcifications are considered a pathognomonic feature of this disorder. We present two patients with Zellweger syndrome, according to the diagnosis suggested by our Radiodiagnostic Service. Our objective is to stress the importance of the radiological findings, which in many cases are decisive in establishing the definitive diagnosis. (Author) 10 refs

[Effects of Cangfu Congxian Decoction on Oxidative Stress in Polycystic Ovary Syndrome Patients].

Science.gov (United States)

Liang, Ying; Tian, Qian-hua; Mu, Yu-xia; Du, Hui-lan

2016-06-01

To observe the effect of Cangfu Congxian Decoction (CCD) on oxidative stress in granulosa cells of polycystic ovary syndrome (PCOS) patients. Forty PCOS patients underwent in vitro fertilization-embryo transfer (IVF-ET) were assigned to the treatment group and the control group 1 according to random digit table, 20 in each group. Patients in the treatment group took CCD (200 mL, once in the morning and once in the afternoon) 2 months before IVF-ET, while those in the control group 1 took no Chinese medical decoction. Recruited were another 20 patients undergoing IVF-ET for tubal factors (as the control group 2). The clinical effect of IVF-ET were observed, including oocyte retrieval number, 2 pronuclear (2PN) fertilization rate, good quality embryo rate, clinical pregnancy rate, and ovarian hyperstimulation syndrome (OHSS) induced transplantation cancel rate. The expression of relative oxygen species (ROS) in granulosa cells was detected using cell immunofluorescence combined with confocal microscopy and FCM. Compared with the control group 1, occyte retrieval number, 2PN fertilization rate, and good quality embryo rate increased in the control group 2 and the treatment group (P <0. 05). OHSS induced transplantation cancel rate decreased in the control group 2 (P < 0.05). Fluorescence intensity of ROS decreased in the treatment group and the control group 2, as compared with the control group 1 (P < 0.01). CCD increased good quality embryo rate by down-regulating the expression of ROS protein in ovarian granulosa cells, and correcting in vivo oxidative stress.

Stress fracture and premenstrual syndrome in Japanese adolescent athletes: a cross-sectional study.

Science.gov (United States)

Takeda, Takashi; Imoto, Yoko; Nagasawa, Hiroyo; Takeshita, Atsuko; Shiina, Masami

2016-10-18

To investigate the relationship between the occurrence of stress fracture and premenstrual syndrome (PMS)/premenstrual dysphoric disorder (PMDD) in Japanese adolescent athletes. Cross-sectional study. Osaka, Japan. A school-based survey on menstruation and school life was conducted using a sample of 1818 Japanese female students who belonged to two public high schools in Japan. Among them, we recruited 394 athletes who had regular menstrual cycles (25-38 days) and completed a questionnaire about their premenstrual symptoms and their competitive career. Premenstrual symptoms and the occurrence of stress fracture. The prevalences of moderate-to-severe PMS and PMDD were 8.9% and 1.3%, respectively, which were the same as in collegiate athletes in a previous study. Premenstrual symptoms disturbed 'Work efficiency or productivity, home responsibilities', 'Relationships with coworkers or family' and 'Athletic performance in training or competition' more severely than menstrual pain (p=0.031, p=0.004 and p<0.001, respectively). 66 athletes (16.8%) reported having experienced a stress fracture. The severity of 'Overeating or food cravings', 'Physical symptoms' and 'Performance in training or competition' in athletes with previous stress fractures were much higher than in those without a history of stress fractures (p=0.015, p=0.008 and p=0.006, respectively). In terms of premenstrual symptoms, 'Physical symptoms' was associated with an increased risk of stress fractures in athletes (OR 1.66, 95% CI 1.06 to 2.62). The results from this study indicated that premenstrual symptoms may affect athletic performance and has the risk of stress fractures in adolescent athletes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Land Acquisition and Relocation Assistance for Airport Improvement Program (AIP) Assisted Projects

Science.gov (United States)

2017-07-10

This advisory circular (AC) provides guidance to sponsors of airport projects developed under the Airport Improvement Program (AIP) to meet the requirements of the Uniform Relocation Assistance and Real Property Acquisition Policies Act of 1970 (Pl 9...

Environmental Perceptions and Health before and after Relocation to a Green Building.

Science.gov (United States)

MacNaughton, Piers; Spengler, John; Vallarino, Jose; Santanam, Suresh; Satish, Usha; Allen, Joseph

2016-08-01

Green buildings are designed to have low environmental impacts and improved occupant health and well-being. Improvements to the built environment including ventilation, lighting, and materials have resulted in improved indoor environmental quality (IEQ) in green buildings, but the evidence around occupant health is currently centered around environmental perceptions and self-reported health. To investigate the objective impact of green buildings on health, we tracked IEQ, self-reported health, and heart rate in 30 participants from green and conventional buildings for two weeks. 24 participants were then selected to be relocated to the Syracuse Center of Excellence, a LEED platinum building, for six workdays. While they were there, ventilation, CO 2 , and volatile organic compound (VOC) levels were changed on different days to match the IEQ of conventional, green, and green+ (green with increased ventilation) buildings. Participants reported improved air quality, odors, thermal comfort, ergonomics, noise and lighting and fewer health symptoms in green buildings prior to relocation. After relocation, participants consistently reported fewer symptoms during the green building conditions compared to the conventional one, yet symptom counts were more closely associated with environmental perceptions than with measured IEQ. On average, participants had 4.7 times the odds of reporting a lack of air movement, 1.4 more symptoms (p-value = 0.019) and a 2 bpm higher heart rate (p-value green and conventional buildings is driven by both environmental perceptions and physiological pathways.

The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress

International Nuclear Information System (INIS)

Woo, Leslie L.; Futami, Kazunobu; Shimamoto, Akira; Furuichi, Yasuhiro; Frank, Karen M.

2006-01-01

Mutations in the RECQL4 helicase gene have been linked to Rothmund-Thomson syndrome (RTS), which is characterized by poikiloderma, growth deficiency, and a predisposition to cancer. Examination of RECQL4 subcellular localization in live cells demonstrated a nucleoplasmic pattern and, to a lesser degree, staining in nucleoli. Analysis of RECQL4-GFP deletion mutants revealed two nuclear localization regions in the N-terminal region of RECQL4 and a nucleolar localization signal at amino acids 376-386. RECQL4 localization did not change after treatment with the DNA-damaging agents bleomycin, etoposide, UV irradiation and γ irradiation, in contrast to the Bloom and Werner syndrome helicases that relocate to distinct nuclear foci after damage. However, in a significant number of cells exposed to hydrogen peroxide or streptonigrin, RECQL4 accumulated in nucleoli. Using a T7 phage display screen, we determined that RECQL4 interacts with poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme that promotes genomic integrity through its involvement in DNA repair and signaling pathways. The RECQL4 nucleolar localization was inhibited by pretreatment with a PARP-1 inhibitor. The C-terminal portion of RECQL4 was found to be an in vitro substrate for PARP-1. These results demonstrate changes in the intracellular localization of RECQL4 in response to oxidative stress and identify an interaction between RECQL4 and PARP-1

Characterization of a Fasciola gigantica protein carrying two DM9 domains reveals cellular relocalization property.

Science.gov (United States)

Phadungsil, Wansika; Smooker, Peter M; Vichasri-Grams, Suksiri; Grams, Rudi

2016-01-01

Even at the present age of whole-organism analysis, e.g., genomics, transcriptomics, and proteomics, the biological roles of many proteins remain unresolved. Classified among the proteins of unknown function is a family of proteins harboring repeats of the DM9 domain, a 60-75 amino acids motif first described in a small number of Drosophila melanogaster proteins. Proteins may carry two or more DM9 domains either in combination with other domains or as their sole constituent. Here we have characterized a 16.8 kDa Fasciola gigantica protein comprising two tandem repeated DM9 domains (FgDM9-1). The protein was located in the parenchyma of the immature and mature parasite and consequently it was not detected in the ES product of the parasite but only in the whole worm extract. Interestingly, extraction with SDS yielded a substantially higher amount of the protein suggesting association with insoluble cell components. In Sf9 insect cells a heterologously expressed EGFP-FgDM9-1 chimera showed cell-wide distribution but relocated to vesicle-like structures in the cytoplasm after stimulating cellular stress by bacteria, heat shock or chloroquine. These structures did not colocalize with the markers of endocytosis/phagocytosis ubiquitin, RAB7, GABARAP. The same behavior was noted for Aedes aegypti PRS1, a homologous mosquito DM9 protein as a positive control while EGFP did not exhibit such relocation in the insect cells. Cross-linking experiments on soluble recombinant FgDM9-1 indicated that the protein can undergo specific oligomerization. It is speculated that proteins carrying the DM9 domain have a role in vesicular transport in flatworms and insects. Copyright © 2016 Elsevier B.V. All rights reserved.

The adenovirus E4 11 k protein binds and relocalizes the cytoplasmic P-body component Ddx6 to aggresomes

International Nuclear Information System (INIS)

Greer, Amy E.; Hearing, Patrick; Ketner, Gary

2011-01-01

The adenovirus E4 11 k protein, product of E4 ORF3, is required in infection for processes including normal accumulation of viral late mRNAs. 11 k restructures both the nucleus and cytoplasm of infected cells by relocalizing specific host cell target proteins, most strikingly components of nuclear PML oncogenic domains. It is likely that in many cases relocalization inactivates target proteins to produce 11 k's effects, although the mechanism and targets for stimulation of late mRNA accumulation is unknown. We have identified a new set of proteins relocalized by 11 k: at least five protein components of cytoplasmic mRNA processing bodies (p-bodies) are found in 11 k-induced cytoplasmic aggresomes, sites where proteins are inactivated or destroyed. One of these p-body proteins, RNA helicase Ddx6, binds 11 k, suggesting a mechanism for relocalization. Because p-bodies are sites for mRNA degradation, their modification by 11 k may provide an explanation for the role of 11 k in viral late mRNA accumulation.

ASSESSING THE SLEEP QUALITY AND DEPRESSION-ANXIETY-STRESS IN IRRITABLE BOWEL SYNDROME PATIENTS

Directory of Open Access Journals (Sweden)

Nadieh BANIASADI

2017-02-01

Full Text Available ABSTRACT BACKGROUND Irritable bowel syndrome (IBS is one of the most common functional gastrointestinal disorders with chronic abdominal pain and altered bowel habit without any organic reason. Sleep disorders may be associated to IBS. OBJECTIVE We aimed to assess sleep disturbances and depression-anxiety-stress in IBS patients. METHODS In this analytical cross sectional study from November 2013 to May 2014, A total of 123 IBS patients were recruited by simple random sampling. IBS was diagnosed using ROME-III criteria. Demographic and basic data were driven from all patients then Pittsburg Sleep Quality Index questionnaire was utilized to estimate sleep quality and DASS (depression anxiety stress scale questionnaire was filled out for depression, anxiety and stress. RESULTS The mean age of patients was 29±9, where 48 cases (39% were male. Twelve cases (10% had a background disease. Types of IBS in patients were included 38% diarrhea, 42% constipation and 20% mixed. From all IBS patients 87 (71% cases had depression, 97 (79% patients stress, 94 (76% patients had anxiety. Seventy-six (62% cases of IBS patients had poor sleep quality. Simultaneously employing predictors demonstrate that gender, background disease, and type of IBS did not statistically significant. On the other hand, depression (P=0.034, OR=2.35, anxiety (P=0.011, OR=3.022, and stress (P=0.029, OR=2.77 were significantly effect on sleep quality in poor sleepers. CONCLUSION Many of IBS patients is suffering from poor sleep quality. It seems that sleep disorder should be considered and treated in this patients.

ASSESSING THE SLEEP QUALITY AND DEPRESSION-ANXIETY-STRESS IN IRRITABLE BOWEL SYNDROME PATIENTS.

Science.gov (United States)

Baniasadi, Nadieh; Dehesh, Mohammad Moein; Mohebbi, Elham; Hayatbakhsh Abbasi, Mahdy; Oghabian, Zohreh

2017-01-01

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders with chronic abdominal pain and altered bowel habit without any organic reason. Sleep disorders may be associated to IBS. We aimed to assess sleep disturbances and depression-anxiety-stress in IBS patients. In this analytical cross sectional study from November 2013 to May 2014, A total of 123 IBS patients were recruited by simple random sampling. IBS was diagnosed using ROME-III criteria. Demographic and basic data were driven from all patients then Pittsburg Sleep Quality Index questionnaire was utilized to estimate sleep quality and DASS (depression anxiety stress scale) questionnaire was filled out for depression, anxiety and stress. The mean age of patients was 29±9, where 48 cases (39%) were male. Twelve cases (10%) had a background disease. Types of IBS in patients were included 38% diarrhea, 42% constipation and 20% mixed. From all IBS patients 87 (71%) cases had depression, 97 (79%) patients stress, 94 (76%) patients had anxiety. Seventy-six (62%) cases of IBS patients had poor sleep quality. Simultaneously employing predictors demonstrate that gender, background disease, and type of IBS did not statistically significant. On the other hand, depression (P=0.034, OR=2.35), anxiety (P=0.011, OR=3.022), and stress (P=0.029, OR=2.77) were significantly effect on sleep quality in poor sleepers. Many of IBS patients is suffering from poor sleep quality. It seems that sleep disorder should be considered and treated in this patients.

A sustained hypothalamic-pituitary-adrenal axis response to acute psychosocial stress in irritable bowel syndrome.

Science.gov (United States)

Kennedy, P J; Cryan, J F; Quigley, E M M; Dinan, T G; Clarke, G

2014-10-01

Despite stress being considered a key factor in the pathophysiology of the functional gastrointestinal (GI) disorder irritable bowel syndrome (IBS), there is a paucity of information regarding the ability of IBS patients to respond to acute experimental stress. Insights into the stress response in IBS could open the way to novel therapeutic interventions. To this end, we assessed the response of a range of physiological and psychological parameters to the Trier Social Stress Test (TSST) in IBS. Thirteen female patients with IBS and 15 healthy female age-matched control participants underwent a single exposure to the TSST. Salivary cortisol, salivary C-reactive protein (CRP), skin conductance level (SCL), GI symptoms, mood and self-reported stress were measured pre- and post-exposure to the TSST. The hypothalamic-pituitary-adrenal (HPA) axis response to the TSST was sustained in IBS, as shown by a greater total cortisol output throughout (p = 0.035) and higher cortisol levels measured by an area under the curve with respect to ground (AUCG) analysis (p = 0.044). In IBS patients, GI symptoms increased significantly during the recovery period following exposure to the TSST (p = 0.045). Salivary CRP and SCL activity showed significant changes in relation to stress but with no differential effect between experimental groups. Patients with IBS exhibit sustained HPA axis activity, and an increase in problematic GI symptoms in response to acute experimental psychosocial stress. These data pave the way for future interventional studies aimed at identifying novel therapeutic approaches to modulate the HPA axis and GI symptom response to acute psychosocial stress in IBS.

Growth Rate and Relocation Movements of Common Nighthawk (Chordeiles minor) Nestlings in Relation to Age

Science.gov (United States)

Kramer, Gunnar R.; Chalfoun, Anna D.

2012-01-01

Relocation by dependent young is a survival strategy that occurs among a wide range of taxa. The Common Nighthawk (Chordeiles minor) lays its eggs on bare substrate and, once hatched, nestlings may relocate to new sites daily. We located and monitored eight Common Nighthawk nests in Grand Teton National Park, Wyoming, quantified inter-use-site distances in relation to nestling age, and calculated a nestling growth rate curve. Common Nighthawk nestlings grow in a nearly linear fashion. Nestlings moved up to 48 m in a single day and larger, older nestlings tended to move greater distances between daily use-sites.

Foreign investment, divestment and relocation by Japanese electronics firms in East Asia

NARCIS (Netherlands)

Belderbos, R.A.; Zou, J.

2006-01-01

Although foreign divestment and international relocation by multinational firms carry important economic implications for the industrialization of East Asian countries, there has been little empirical research on these issues. In this paper we analyze the magnitude and pattern of foreign divestment

[Burnout syndrome: a "true" cardiovascular risk factor].

Science.gov (United States)

Cursoux, Pauline; Lehucher-Michel, Marie-Pascale; Marchetti, Hélène; Chaumet, Guillaume; Delliaux, Stéphane

2012-11-01

The burnout syndrome is characterized by emotional exhaustion, depersonalization and reduced personal accomplishment in individuals professionally involved with others. The burnout syndrome is poorly recognized, particularly in France, as a distinct nosology from adaptation troubles, stress, depression, or anxiety. Several tools quantifying burnout and emotional exhaustion exist, the most spread is the questionnaire called Maslach Burnout Inventory. The burnout syndrome alters cardiovascular function and its neuroregulation by autonomic nervous system and is associated with: increased sympathetic tone to heart and vessels after mental stress, lowered physiological post-stress vagal rebound to heart, and lowered arterial baroreflex sensitivity. Job strain as burnout syndrome seems to be a real independent cardiovascular risk factor. Oppositely, training to manage emotions could increase vagal tone to heart and should be cardio-protective. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Interstitial Cystitis/Painful Bladder Syndrome and Associated Medical Conditions With an Emphasis on Irritable Bowel Syndrome, Fibromyalgia and Chronic Fatigue Syndrome

DEFF Research Database (Denmark)

Nickel, J.C.; Tripp, D.A.; Pontari, M.

2010-01-01

of associated conditions increased (ie localized, regional, systemic), pain, stress, depression and sleep disturbance increased while social support, sexual functioning and quality of life deteriorated. Anxiety and catastrophizing remained increased in all groups. Symptom duration was associated......Purpose: We characterized and compared the impact of clinical phenotypic associations between interstitial cystitis/painful bladder syndrome and controls in relation to potentially related conditions, particularly irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome. Materials...... cystitis/painful bladder syndrome vs controls was irritable bowel syndrome 38.6% vs 5.2%, fibromyalgia 17.7% vs 2.6% and chronic fatigue syndrome 9.5% vs 1.7% (all p

Traumatic memories, post-traumatic stress disorder and serum cortisol levels in long-term survivors of the acute respiratory distress syndrome

NARCIS (Netherlands)

Hauer, Daniela; Weis, Florian; Krauseneck, Till; Vogeser, Michael; Schelling, Gustav; Roozendaal, Benno

2009-01-01

Survivors of the acute respiratory distress syndrome (ARDS) often report traumatic memories from the intensive care unit (ICU) and display a high incidence of post-traumatic stress disorder (PTSD). As it is known that subjects with PTSD often show sustained reductions in circulating cortisol

"Shin splint" syndrome and tibial stress fracture in the same patient diagnosed by means of (99m)Tc-HMDP SPECT/CT.

Science.gov (United States)

Vicente, Justo Serrano; Grande, Maria Luz Domínguez; Torre, Jose Rafael Infante; Madrid, Juan Ignacio Rayo; Barquero, Carmen Durán; Bernardo, Lucía García; Sánchez, Román Sánchez

2013-04-01

We show a patient who presented leg pain triggered by intense exercise. The most likely diagnosis was a possible tibial stress fracture or a "shin splint" syndrome (soleus enthesopathy). We performed a bone scintigraphy including SPECT/CT that revealed the presence of the two concomitant pathologies. SPECT/CT identified the hot spot superimposed with bone lesion in the tibial stress fracture and only remodeling activity without evidence of cortical lesions in the enthesopathy processes.

Should We Leave? Attitudes towards Relocation in Response to Sea Level Rise

Directory of Open Access Journals (Sweden)

Jie Song

2017-12-01

Full Text Available The participation of individuals contributes significantly to the success of sea level rise adaptation. This study therefore addresses what influences people’s likelihood of relocating away from low-lying areas in response to rising sea levels. The analysis was based on a survey conducted in the City of Panama Beach in Florida (USA. Survey items relate to people’s risk perception, hazard experience, threat appraisal, and coping appraisal, whose theoretical background is Protection Motivation Theory. Descriptive and correlation analysis was first performed to highlight critical factors which were then examined by a multinomial Logit model. Results show that sea level rise awareness is the major explanatory variable. Coping appraisal is qualitatively viewed as a strong predictor for action, while threat appraisal is statistically significant in driving relocation intention. These factors should be integrated in current risk communication regarding sea level rise.

Earthquake hypocenter relocation using double difference method in East Java and surrounding areas

International Nuclear Information System (INIS)

C, Aprilia Puspita; Nugraha, Andri Dian; Puspito, Nanang T

2015-01-01

Determination of precise hypocenter location is very important in order to provide information about subsurface fault plane and for seismic hazard analysis. In this study, we have relocated hypocenter earthquakes in Eastern part of Java and surrounding areas from local earthquake data catalog compiled by Meteorological, Climatological, and Geophysical Agency of Indonesia (MCGA) in time period 2009-2012 by using the double-difference method. The results show that after relocation processes, there are significantly changes in position and orientation of earthquake hypocenter which is correlated with the geological setting in this region. We observed indication of double seismic zone at depths of 70-120 km within the subducting slab in south of eastern part of Java region. Our results will provide useful information for advance seismological studies and seismic hazard analysis in this study

Earthquake hypocenter relocation using double difference method in East Java and surrounding areas

Energy Technology Data Exchange (ETDEWEB)

C, Aprilia Puspita [Geophysical Engineering Program, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung (Indonesia); Meteorological, Climatological, and Geophysical Agency (MCGA) of Indonesian, Jakarta (Indonesia); Nugraha, Andri Dian, E-mail: nugraha@gf.itb.ac.id [Geophysical Engineering Program, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung (Indonesia); Puspito, Nanang T [Global Geophysical Research Group, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung (Indonesia)

2015-04-24

Determination of precise hypocenter location is very important in order to provide information about subsurface fault plane and for seismic hazard analysis. In this study, we have relocated hypocenter earthquakes in Eastern part of Java and surrounding areas from local earthquake data catalog compiled by Meteorological, Climatological, and Geophysical Agency of Indonesia (MCGA) in time period 2009-2012 by using the double-difference method. The results show that after relocation processes, there are significantly changes in position and orientation of earthquake hypocenter which is correlated with the geological setting in this region. We observed indication of double seismic zone at depths of 70-120 km within the subducting slab in south of eastern part of Java region. Our results will provide useful information for advance seismological studies and seismic hazard analysis in this study.

Role of Oxidative Stress in the Neurocognitive Dysfunction of Obstructive Sleep Apnea Syndrome

Directory of Open Access Journals (Sweden)

Li Zhou

2016-01-01

Full Text Available Obstructive sleep apnea syndrome (OSAS is characterized by chronic nocturnal intermittent hypoxia and sleep fragmentations. Neurocognitive dysfunction, a significant and extraordinary complication of OSAS, influences patients’ career, family, and social life and reduces quality of life to some extent. Previous researches revealed that repetitive hypoxia and reoxygenation caused mitochondria and endoplasmic reticulum dysfunction, overactivated NADPH oxidase, xanthine oxidase, and uncoupling nitric oxide synthase, induced an imbalance between prooxidants and antioxidants, and then got rise to a series of oxidative stress (OS responses, such as protein oxidation, lipid peroxidation, and DNA oxidation along with inflammatory reaction. OS in brain could trigger neuron injury especially in the hippocampus and cerebral cortex regions. Those two regions are fairly susceptible to hypoxia and oxidative stress production which could consequently result in cognitive dysfunction. Apart from continuous positive airway pressure (CPAP, antioxidant may be a promising therapeutic method to improve partially reversible neurocognitive function. Understanding the role that OS played in the cognitive deficits is crucial for future research and therapeutic strategy development. In this paper, recent important literature concerning the relationship between oxidative stress and cognitive impairment in OSAS will be summarized and the results can provide a rewarding overview for future breakthrough in this field.

Relocation of radioactive residuals store: environment effects statement

International Nuclear Information System (INIS)

1984-11-01

This Environment Effects Statement describes and assesses the likely environmental effects of the proposal to relocate the Health Commission's existing radioactive residuals store to a site within the established Dutson Downs waste disposal area, located 20 km south-east of Sale and 225 km east of Melbourne. The information presented demonstrates that the siting and construction of the proposed radioactive residuals store and the procedures to be adopted for the handling and storage of materials will not present an unacceptable risk to public health and safety, nor will it involve any significant adverse environmental effects

Motivations for active commuting: a qualitative investigation of the period of home or work relocation.

Science.gov (United States)

Jones, Caroline H D; Ogilvie, David

2012-09-11

Promoting walking or cycling to work (active commuting) could help to increase population physical activity levels. According to the habit discontinuity and residential self-selection hypotheses, moving home or workplace is a period when people (re)assess, and may be more likely to change, their travel behavior. Research in this area is dominated by the use of quantitative research methods, but qualitative approaches can provide in-depth insight into the experiences and processes of travel behavior change. This qualitative study aimed to explore experiences and motivations regarding travel behavior around the period of relocation, in an effort to understand how active commuting might be promoted more effectively. Participants were recruited from the Commuting and Health in Cambridge study cohort in the UK. Commuters who had moved home, workplace or both between 2009 and 2010 were identified, and a purposive sample was invited to participate in semi-structured interviews regarding their experiences of, and travel behavior before and after, relocating. A grounded theory approach was taken to analysis. Twenty-six commuters participated. Participants were motivated by convenience, speed, cost and reliability when selecting modes of travel for commuting. Physical activity was not a primary motivation, but incidental increases in physical activity were described and valued in association with active commuting, the use of public transport and the use of park-and-ride facilities. Emphasizing and improving the relative convenience, cost, speed and reliability of active commuting may be a more promising approach to promoting its uptake than emphasizing the health benefits, at least around the time of relocation. Providing good quality public transport and free car parking within walking or cycling distance of major employment sites may encourage the inclusion of active travel in the journey to work, particularly for people who live too far from work to walk or cycle the

Motivations for active commuting: a qualitative investigation of the period of home or work relocation

Directory of Open Access Journals (Sweden)

Jones Caroline HD

2012-09-01

Full Text Available Abstract Background Promoting walking or cycling to work (active commuting could help to increase population physical activity levels. According to the habit discontinuity and residential self-selection hypotheses, moving home or workplace is a period when people (reassess, and may be more likely to change, their travel behavior. Research in this area is dominated by the use of quantitative research methods, but qualitative approaches can provide in-depth insight into the experiences and processes of travel behavior change. This qualitative study aimed to explore experiences and motivations regarding travel behavior around the period of relocation, in an effort to understand how active commuting might be promoted more effectively. Methods Participants were recruited from the Commuting and Health in Cambridge study cohort in the UK. Commuters who had moved home, workplace or both between 2009 and 2010 were identified, and a purposive sample was invited to participate in semi-structured interviews regarding their experiences of, and travel behavior before and after, relocating. A grounded theory approach was taken to analysis. Results Twenty-six commuters participated. Participants were motivated by convenience, speed, cost and reliability when selecting modes of travel for commuting. Physical activity was not a primary motivation, but incidental increases in physical activity were described and valued in association with active commuting, the use of public transport and the use of park-and-ride facilities. Conclusions Emphasizing and improving the relative convenience, cost, speed and reliability of active commuting may be a more promising approach to promoting its uptake than emphasizing the health benefits, at least around the time of relocation. Providing good quality public transport and free car parking within walking or cycling distance of major employment sites may encourage the inclusion of active travel in the journey to work

Relocation of cryopreserved umbilical cord blood samples using a high-capacity dry shipper to a new laboratory: a cord blood banking experience.

Science.gov (United States)

Thiagarajah, Kalaivani; Wong, Chee-Yin; Vijayan, Vickneswary Veera; Ooi, Ghee-Chien; Ng, Mei-Theng; Cheong, Soon-Keng; Then, Kong-Yong

2015-05-01

Processed umbilical cord blood (UCB) must be stored at cryogenic temperature at all times to maintain the quality and viability of the cells. However, a challenge is presented in the form of moving a large number of cryopreserved UCB samples to a new location. In this report, we share our experience on relocating more than 100,000 units of cryopreserved UCB samples stored in 12 liquid nitrogen freezers (LNFs) to our new laboratory. For quality control purposes, 2 weeks before relocation, donor UCB samples were processed, cryopreserved, and stored in each LNF. On relocation day, half of the samples were retrieved to determine total nucleated cell count, percentage of CD34+ cells, and cell viability as controls for later comparison. UCB samples were transferred into dry shippers before being relocated to the new laboratory. Upon arrival, LNFs were serviced before transferring UCB samples back into its original location within the LNF. The remaining donor UCB samples were retrieved and analyzed for the same tests mentioned. We found no significant differences in pre- and postrelocation values of the tests performed. All UCB samples were successfully relocated into the new laboratory without affecting the quality. © 2014 AABB.

Classification of delocalization power of global unitary operations in terms of LOCC one-piece relocalization

Directory of Open Access Journals (Sweden)

Akihito Soeda

2010-06-01

Full Text Available We study how two pieces of localized quantum information can be delocalized across a composite Hilbert space when a global unitary operation is applied. We classify the delocalization power of global unitary operations on quantum information by investigating the possibility of relocalizing one piece of the quantum information without using any global quantum resource. We show that one-piece relocalization is possible if and only if the global unitary operation is local unitary equivalent of a controlled-unitary operation. The delocalization power turns out to reveal different aspect of the non-local properties of global unitary operations characterized by their entangling power.

Nest Relocation and Colony Founding in the Australian Desert Ant, Melophorus bagoti Lubbock (Hymenoptera: Formicidae

Directory of Open Access Journals (Sweden)

Patrick Schultheiss

2010-01-01

Full Text Available Even after years of research on navigation in the Red Honey Ant, Melophorus bagoti, much of its life history remains elusive. Here, we present observations on nest relocation and the reproductive and founding stages of colonies. Nest relocation is possibly aided by trail laying behaviour, which is highly unusual for solitary foraging desert ants. Reproduction occurs in synchronised mating flights, which are probably triggered by rain. Queens may engage in multiple matings, and there is circumstantial evidence that males are chemically attracted to queens. After the mating flight, the queens found new colonies independently and singly. Excavation of these founding colonies reveals first insights into their structure.

Model for melt blockage (slug) relocation and physico-chemical interactions during core degradation under severe accident conditions

International Nuclear Information System (INIS)

Veshchunov, M.S.; Shestak, V.E.

2008-01-01

The model describing massive melt blockage (slug) relocation and physico-chemical interactions with steam and surrounding fuel rods of a bundle is developed on the base of the observations in the CORA tests. Mass exchange owing to slug oxidation and fuel rods dissolution is described by the previously developed 2D model for the molten pool oxidation. Heat fluxes in oxidising melt along with the oxidation heat effect at the melt relocation front are counterbalanced by the heat losses in the surrounding media and the fusion heat effect of the Zr claddings attacked by the melt. As a result, the slug relocation velocity is calculated from the heat flux matches at the melt propagation front (Stefan problem). A numerical module simulating the slug behaviour is developed by tight coupling of the heat and mass exchange modules. The new model demonstrates a reasonable capability to simulate the main features of the massive slug behaviour observed in the CORA-W1 test

Oxidative Stress in Complex Regional Pain Syndrome (CRPS): No Systemically Elevated Levels of Malondialdehyde, F2-Isoprostanes and 8OHdG in a Selected Sample of Patients

NARCIS (Netherlands)

Fischer, S.G.L.; Perez, R.S.G.M.; Nouta, J.; Zuurmond, W.W.A.; Scheffer, P.G.

2013-01-01

Exaggerated inflammation and oxidative stress are involved in the pathogenesis of Complex Regional Pain Syndrome (CRPS). However, studies assessing markers for oxidative stress in CRPS patients are limited. In this study, markers for lipid peroxidation (malondialdehyde and F2-isoprostanes) and DNA

Moving to an active lifestyle? A systematic review of the effects of residential relocation on walking, physical activity and travel behaviour.

Science.gov (United States)

Ding, Ding; Nguyen, Binh; Learnihan, Vincent; Bauman, Adrian E; Davey, Rachel; Jalaludin, Bin; Gebel, Klaus

2018-06-01

To synthesise the literature on the effects of neighbourhood environmental change through residential relocation on physical activity, walking and travel behaviour. Systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO registration number CRD42017077681). Electronic databases for peer-reviewed and grey literature were systematically searched to March 2017, followed by forward and backward citation tracking. A study was eligible for inclusion if it (1) measured changes in neighbourhood built environment attributes as a result of residential relocation (either prospectively or retrospectively); (2) included a measure of physical activity, walking, cycling or travel modal change as an outcome; (3) was quantitative and (4) included an English abstract or summary. A total of 23 studies was included in the review. Among the eight retrospective longitudinal studies, there was good evidence for the relationship between relocation and walking (consistency score (CS)>90%). For the 15 prospective longitudinal studies, the evidence for the effects of environmental change/relocation on physical activity or walking was weak to moderate (CS mostly <45%), even weaker for effects on other outcomes, including physical activity, cycling, public transport use and driving. Results from risk of bias analyses support the robustness of the findings. The results are encouraging for the retrospective longitudinal relocation studies, but weaker evidence exists for the methodologically stronger prospective longitudinal relocation studies. The evidence base is currently limited, and continued longitudinal research should extend the plethora of cross-sectional studies to build higher-quality evidence. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Preliminary evaluation of crisis-relocation fallout-shelter options. Volume 2. Detailed analysis

International Nuclear Information System (INIS)

Santini, D.J.; Clinch, J.M.; Davis, F.H.; Hill, L.G.; Lynch, E.P.; Tanzman, E.A.; Wernette, D.R.

1982-12-01

This report presents a preliminary, detailed evaluation of various shelter options for use if the President orders crisis relocation of the US urban population because of strong expectation of a nuclear war. The availability of livable shelter space at 40 ft 2 per person (congregate-care space) by state is evaluated. Options are evaluated for construction of fallout shelters allowing 10 ft 2 per person - such shelters are designed to provide 100% survival at projected levels of radioactive fallout. The FEMA concept of upgrading existing buildings to act as fallout shelters can, in principle, provide adequate shelter throughout most of the US. Exceptions are noted and remedies proposed. In terms of upgrading existing buildings to fallout shelter status, great benefits are possible by turning away from a standard national approach and adopting a more site-specific approach. Existing FEMA research provides a solid foundation for successful crisis relocation planning, but the program can be refined by making suitable modifications in its locational, engineering, and institutionally specific elements

Parenting children with down syndrome: An analysis of parenting styles, parenting dimensions, and parental stress.

Science.gov (United States)

Phillips, B Allyson; Conners, Frances; Curtner-Smith, Mary Elizabeth

2017-09-01

Effective parenting is vital for a child's development. Although much work has been conducted on parenting typically developing children, little work has examined parenting children with Down syndrome. The purpose of the current study was to compare the parenting styles and dimensions in mothers of children with DS and mothers of TD children. Thirty-five mothers of children with DS and 47 mothers of TD children completed questionnaires about parenting, parental stress, child behavior problems, and child executive function. We found that mothers of children with DS use an authoritative parenting style less and a permissive parenting style more than mothers of TD children. Additionally, we found that mothers of children with DS use reasoning/induction and verbal hostility less and ignoring misbehavior more than mothers of TD children. All of these differences, except for those of reasoning/induction, were at least partially accounted for by the higher levels of parental stress in the DS group. Parenting interventions should be focused on reducing parental stress and training mothers to parent under stress in an effort to improve parenting techniques, which would, in theory, improve long-term child outcomes for children with DS. Copyright © 2017 Elsevier Ltd. All rights reserved.

Effect of Ramadan Fasting on Stress Neurohormones in Women with Polycystic Ovary Syndrome.

Science.gov (United States)

Zangeneh, Farideh; Salman Yazdi, Reza; Naghizadeh, Mohammad Mehdi; Abedinia, Nasrin

2015-06-01

To determine the effects of Ramadan fasting on serum levels of stress neurohormones in Iranian women with polycystic ovary syndrome (PCOS). This study was a clinical trial and was performed during July 2011 (month of Ramadan) in Royan institute, Tehran. A total of 40 women who were aged 20-40 years and known cases of PCOS and had no other medical diseases were included in the study. They were divided into two groups as follows: (i) study group (n = 20) who participated in Ramadan fasting and (ii) control group (n = 20) who did not participate in fasting. For evaluating Ramadan's effect on the level of neurohormones serum level of the following variables were evaluated before and after Ramadan: cortisol, adrenaline (A), noradrenalin (NA), beta-endorphin (β-End), insulin, as well as sex hormones including follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone. In the study group after Ramadan serum cortisol and nor-adrenaline levels were significantly lower than the initial levels obtained at beginning of Ramadan (p Ramadan fasting decreases stress neurohormones in women with PCOS.

MRI Shows that Exhaustion Syndrome Due to Chronic Occupational Stress is Associated with Partially Reversible Cerebral Changes.

Science.gov (United States)

Savic, I; Perski, A; Osika, W

2018-03-01

The present study investigates the cerebral effects of chronic occupational stress and its possible reversibility. Forty-eight patients with occupational exhaustion syndrome (29 women) and 80 controls (47 women) underwent structural magnetic resonance imaging (MRI) and neuropsychological testing. Forty-four participants (25 patients, 19 controls) also completed a second MRI scan after 1-2 years. Only patients received cognitive therapy. The stressed group at intake had reduced thickness in the right prefrontal cortex (PFC) and left superior temporal gyrus (STG), enlarged amygdala volumes, and reduced caudate volumes. Except for the caudate volume, these abnormalities were more pronounced in females. They were all related to perceived stress, which was similar for both genders. Thickness of the PFC also correlated with an impaired ability to down-modulate negative emotions. Thinning of PFC and reduction of caudate volume normalized in the follow-up. The amygdala enlargement and the left STG thinning remained. Longitudinal changes were not detected among controls. Chronic occupational stress was associated with partially reversible structural abnormalities in key regions for stress processing. These changes were dynamically correlated with the degree of perceived stress, highlighting a possible causal link. They seem more pronounced in women, and could be a substrate for an increased cerebral vulnerability to stress-related psychiatric disorders. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Stress management skills, neuroimmune processes and fatigue levels in persons with chronic fatigue syndrome.

Science.gov (United States)

Lattie, Emily G; Antoni, Michael H; Fletcher, Mary Ann; Penedo, Frank; Czaja, Sara; Lopez, Corina; Perdomo, Dolores; Sala, Andreina; Nair, Sankaran; Fu, Shih Hua; Klimas, Nancy

2012-08-01

Stressors and emotional distress responses impact chronic fatigue syndrome (CFS) symptoms, including fatigue. Having better stress management skills might mitigate fatigue by decreasing emotional distress. Because CFS patients comprise a heterogeneous population, we hypothesized that the role of stress management skills in decreasing fatigue may be most pronounced in the subgroup manifesting the greatest neuroimmune dysfunction. In total, 117 individuals with CFS provided blood and saliva samples, and self-report measures of emotional distress, perceived stress management skills (PSMS), and fatigue. Plasma interleukin-1-beta (IL-1β, IL-2, IL-6, IL-10, and tumor necrosis factor-alpha (TNF-α), and diurnal salivary cortisol were analyzed. We examined relations among PSMS, emotional distress, and fatigue in CFS patients who did and did not evidence neuroimmune abnormalities. Having greater PSMS related to less fatigue (p=.019) and emotional distress (pfatigue levels most strongly in CFS patients in the top tercile of IL-6, and emotional distress mediated the relationship between PSMS and fatigue most strongly in patients with the greatest circulating levels of IL-6 and a greater inflammatory (IL-6):anti-inflammatory (IL-10) cytokine ratio. CFS patients having greater PSMS show less emotional distress and fatigue, and the influence of stress management skills on distress and fatigue appear greatest among patients who have elevated IL-6 levels. These findings support the need for research examining the impact of stress management interventions in subgroups of CFS patients showing neuroimmune dysfunction. Copyright © 2012 Elsevier Inc. All rights reserved.

78 FR 8550 - Relocation of Regulations and Rulings, Office of International Trade

Science.gov (United States)

2013-02-06

... Rulings, Office of International Trade AGENCY: U.S. Customs and Border Protection, Department of Homeland... International Trade, of the U.S. Customs and Border Protection (CBP) is relocating its office from the U.S. Mint... correspondence directed to the Regulations and Rulings, Office of International Trade, including mailed comments...

Move it or lose it? The ecological ethics of relocating species under climate change.

Science.gov (United States)

Minteer, Ben A; Collins, James P

2010-10-01

Managed relocation (also known as assisted colonization, assisted migration) is one of the more controversial proposals to emerge in the ecological community in recent years. A conservation strategy involving the translocation of species to novel ecosystems in anticipation of range shifts forced by climate change, managed relocation (MR) has divided many ecologists and conservationists, mostly because of concerns about the potential invasion risk of the relocated species in their new environments. While this is indeed an important consideration in any evaluation of MR, moving species across the landscape in response to predicted climate shifts also raises a number of larger and important ethical and policy challenges that need to be addressed. These include evaluating the implications of a more aggressive approach to species conservation, assessing MR as a broader ecological policy and philosophy that departs from longstanding scientific and management goals focused on preserving ecological integrity, and considering MR within a more comprehensive ethical and policy response to climate change. Given the complexity and novelty of many of the issues at stake in the MR debate, a more dynamic and pragmatic approach to ethical analysis and debate is needed to help ecologists, conservationists, and environmental decision makers come to grips with MR and the emerging ethical challenges of ecological policy and management under global environmental change.

41 CFR 302-12.113 - Under a homesale program, may we direct the relocation services company to pay an employee more...

Science.gov (United States)

2010-07-01

..., may we direct the relocation services company to pay an employee more than the fair market value of... we direct the relocation services company to pay an employee more than the fair market value of his... an employee more than the fair market value (as determined by the residence appraisal process) of his...

Hochu-ekki-to Treatment Improves Reproductive and Immune Modulation in the Stress-Induced Rat Model of Polycystic Ovarian Syndrome.

Science.gov (United States)

Park, Eunkuk; Choi, Chun Whan; Kim, Soo Jeong; Kim, Yong-In; Sin, Samkee; Chu, Jong-Phil; Heo, Jun Young

2017-06-13

The traditional herbal medicine, Hochu-ekki-to, has been shown to have preventive effects on viral infection and stress. This study aimed to evaluate the clinical effects of Hochu-ekki-to on two stress-related rat models of polycystic ovarian syndrome. Female Sprague-Dawley rats were divided into control and treatment groups, the latter of which were subjected to stress induced by exposure to adrenocorticotropic hormone (ACTH) or cold temperatures. After these stress inductions, rats were orally treated with dissolved Hochu-ekki-to once per day for 7 days. Rats subjected to the two different stressors exhibited upregulation of steroid hormone receptors (in ovaries) and reproductive hormones (in blood), and consequent stimulation of abnormal follicle development accompanied by elevation of Hsp 90 expression (in ovaries). Treatment with Hochu-ekki-to for 7 days after stress induction increased immune functions, reduced the stress-induced activation of Hsp 90, and normalized the levels of the tested steroid hormone receptors and reproductive hormones. Our findings suggest that stress stimulations may promote the activation of Hsp 90 via the dysregulation of steroid hormone receptors and reproductive hormones, but that post-stress treatment with Hochu-ekki-to improves reproductive and immune functions in the ovaries of stressed rats.

Infusion of Hibiscus sabdariffa L. Modulates Oxidative Stress in Patients with Marfan Syndrome

Science.gov (United States)

Soto, María Elena; Zuñiga-Muñoz, Alejandra; Guarner Lans, Verónica; Duran-Hernández, Erendira Janet; Pérez-Torres, Israel

2016-01-01

Marfan syndrome (MFS) is associated with progressive aortic dilatation, endothelial dysfunction, and oxidative stress that contribute to the early acute dissection of the vessel and can end up in rupture of the aorta and sudden death. Many studies have described that the organic acids from Hibiscus sabdariffa Linne (HSL) calyces increase cellular antioxidant capacity and decrease oxidative stress. Here we evaluate if the antioxidant properties of HSL infusion improve oxidative stress in MFS patients. Activities of extra cellular super oxide dismutase (ECSOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST), glutathione reductase (GSSG-R), glutathione (GSH), lipid peroxidation (LPO) index, total antioxidant capacity (TAC), and ascorbic acid were determined in plasma from MFS patients. Values before and after 3 months of the treatment with 2% HSL infusion were compared in control and MFS subjects. After treatment, there was a significant decrease in ECSOD (p = 0.03), EGPx (p = 0.04), GST (p = 0.03), GSH (p = 0.01), and TAC and ascorbic acid (p = 0.02) but GSSG-R activity (p = 0.04) and LPO (p = 0.02) were increased in MFS patients in comparison to patients receiving the HSL treatment and C subjects. Therefore, the infusion of HSL calyces has antioxidant properties that allow an increase in antioxidant capacity of both the enzymatic and nonenzymatic systems, in the plasma of the MSF patients. PMID:27413258

Infusion of Hibiscus sabdariffa L. Modulates Oxidative Stress in Patients with Marfan Syndrome.

Science.gov (United States)

Soto, María Elena; Zuñiga-Muñoz, Alejandra; Guarner Lans, Verónica; Duran-Hernández, Erendira Janet; Pérez-Torres, Israel

2016-01-01

Marfan syndrome (MFS) is associated with progressive aortic dilatation, endothelial dysfunction, and oxidative stress that contribute to the early acute dissection of the vessel and can end up in rupture of the aorta and sudden death. Many studies have described that the organic acids from Hibiscus sabdariffa Linne (HSL) calyces increase cellular antioxidant capacity and decrease oxidative stress. Here we evaluate if the antioxidant properties of HSL infusion improve oxidative stress in MFS patients. Activities of extra cellular super oxide dismutase (ECSOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST), glutathione reductase (GSSG-R), glutathione (GSH), lipid peroxidation (LPO) index, total antioxidant capacity (TAC), and ascorbic acid were determined in plasma from MFS patients. Values before and after 3 months of the treatment with 2% HSL infusion were compared in control and MFS subjects. After treatment, there was a significant decrease in ECSOD (p = 0.03), EGPx (p = 0.04), GST (p = 0.03), GSH (p = 0.01), and TAC and ascorbic acid (p = 0.02) but GSSG-R activity (p = 0.04) and LPO (p = 0.02) were increased in MFS patients in comparison to patients receiving the HSL treatment and C subjects. Therefore, the infusion of HSL calyces has antioxidant properties that allow an increase in antioxidant capacity of both the enzymatic and nonenzymatic systems, in the plasma of the MSF patients.

Glutathione system in Wolfram syndrome 1‑deficient mice.

Science.gov (United States)

Porosk, Rando; Kilk, Kalle; Mahlapuu, Riina; Terasmaa, Anton; Soomets, Ursel

2017-11-01

Wolfram syndrome 1 (WS) is a rare neurodegenerative disease that is caused by mutations in the Wolfram syndrome 1 (WFS1) gene, which encodes the endoplasmic reticulum (ER) glycoprotein wolframin. The pathophysiology of WS is ER stress, which is generally considered to induce oxidative stress. As WS has a well‑defined monogenetic origin and a model for chronic ER stress, the present study aimed to characterize how glutathione (GSH), a major intracellular antioxidant, was related to the disease and its progression. The concentration of GSH and the activities of reduction/oxidation system enzymes GSH peroxidase and GSH reductase were measured in Wfs1‑deficient mice. The GSH content was lower in most of the studied tissues, and the activities of antioxidative enzymes varied between the heart, kidneys and liver tissues. The results indicated that GSH may be needed for ER stress control; however, chronic ER stress from the genetic syndrome eventually depletes the cellular GSH pool and leads to increased oxidative stress.

The problem of professional burnout in stress management

Directory of Open Access Journals (Sweden)

Makasheva Natalia

2016-01-01

Full Text Available The problem of professional burnout is extremely relevant in current stress management. By its nature, professional burnout is a unique type of stress syndrome that is characterized by emotional exhaustion. It leads to loss of energy and interest in one’s job. A burnout could be the result of such syndromes as – burnout and boreout. It could emerge as the reaction of the organism to the high working intensity and stress working conditions or due to the boredom and absence of the sphere for professional realization. Both syndromes negatively influence the professional activity and require serious research and an adequate approach to the study. Studies have been conducted in the higher educational environment and among production employees. The studies were conducted with the application of the existing tests for revealing the “boreout” and “burnout” syndromes. Studies have shown that the syndrome “burnout” is common among workers with free working regulations, whose work requires greater independence, initiative and responsibility. According to the results of the study, the employees who are more free in the performance of their professional duties (teachers, managers are less subjected to the boreout syndrome. For the prevention and control of professional burnout company management needs to apply the achievements of stress management.

Normal Reactions to Orthostatic Stress in Rett Syndrome

Science.gov (United States)

Larsson, Gunilla; Julu, Peter O. O.; Engerstrom, Ingegerd Witt; Sandlund, Marlene; Lindstrom, Britta

2013-01-01

The aim of this study was to investigate orthostatic reactions in females with Rett syndrome (RTT), and also whether the severity of the syndrome had an impact on autonomic reactions. Based on signs of impaired function of the central autonomic system found in RTT, it could be suspected that orthostatic reactions were affected. The orthostatic…

Relocation due to Climate Change: Mapping the Divergent Responses of the Governments of Tuvalu and Kiribati

Science.gov (United States)

McNamara, K. E.; Hemstock, S.; Smith, R.; Holland, E. A.

2012-12-01

Climate change will continue to impact Pacific Island livelihoods in diverse and complex ways. At the 2009 Copenhagen Conference of Parties to discuss the United Nations Framework Convention on Climate Change, Pacific governments argued for the need to limit warming to 1.5°C. A growing body of literature demonstrates that warming beyond this 2°C threshold is likely and will result in numerous negative impacts on socio-ecological systems across the world, particularly for low-lying coastal communities (Parry et al, 2009; Smith et al, 2009). These communities will need to manage, if possible,a series of interconnected impacts, such as declining freshwater and food security and diminishing land availability, as a result of sea level rise and increasing extreme weather events (Adger and Barnett, 2009). Discussions concerning climate change as a trigger for relocation for low-lying Pacific nations have been contentious, and are fuelled by emotion and varying degrees of sensitivity. As Hayward-Jones (2010: 2) lamented: 'What is at stake over the next decade is not a sinking island but the very viability of life on this fragile atoll state. The land mass of Tuvalu will still exist in 2020 but it may be unable to support the population'. While this debate has historical roots, and indeed the phenomenon of relocation due to localised environmental degradation is not something new in the Pacific, it remains a significant contemporary issue. Scholars have argued that a 'successful mix of strategies' is required to develop culturally-appropriate solutions to this concern about the need for low-lying coastal communities in the Pacific to relocate (Bedford and Bedford, 2010: 93). As such, this paper assesses how the national governments of two low-lying nations in the Pacific - Tuvalu and Kiribati - are mapping out very different long-term strategies to respond to climate change impacts and concerns about the possibility of relocation. The governments of Tuvalu and Kiribati

41 CFR 102-73.305 - What relocation assistance policy must Federal agencies follow?

Science.gov (United States)

2010-07-01

... displaced person for actual— (a) Reasonable moving expenses (in moving himself, his family, and business... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What relocation... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL...

Reassessment of 50 years of seismicity in Simav-Gediz grabens (Western Turkey), based on earthquake relocations

Science.gov (United States)

Karasozen, E.; Nissen, E.; Bergman, E. A.; Walters, R. J.

2013-12-01

Western Turkey is a rapidly deforming region with a long history of high-magnitude normal faulting earthquakes. However, the locations and slip rates of the responsible faults are poorly constrained. Here, we reassess a series of large instrumental earthquakes in the Simav-Gediz region, an area exhibiting a strong E-W gradient in N-S extension rates, from low rates bordering the Anatolian Plateau to much higher rates in the west. We start with investigating a recent Mw 5.9 earthquake at Simav (19 May 2011) using InSAR, teleseismic body-wave modeling and field observations. Next, we exploit the small but clear InSAR signal to relocate a series of older, larger earthquakes, using a calibrated earthquake relocation method which is based on the hypocentroidial decomposition (HDC) method for multiple event relocation. These improved locations in turn provide an opportunity to reassess the regional style of deformation. One interesting aspect of these earthquakes is that the largest (the Mw 7.2 Gediz earthquake, March 1970) occurred in an area of slow extension and indistinct surface faulting, whilst the well-defined and more rapidly extending Simav graben has ruptured in several smaller, Mw 6 events. However, our relocations highlight the existence of a significant gap in instrumental earthquakes along the central Simav graben, which, if it ruptured in a single event, could equal ~Mw 7. We were unable to identify fault scarps along this section due to dense vegetation and human modification, and we suggest that acquiring LiDAR data in this area should be a high priority in order to properly investigate earthquake hazard in the Simav graben.

Targets to treat metabolic syndrome in polycystic ovary syndrome.

Science.gov (United States)

Mahalingaiah, Shruthi; Diamanti-Kandarakis, Evanthia

2015-01-01

Metabolic syndrome is comprised of a combination of the following states: increased insulin resistance, dyslipidemia, cardiovascular disease, and increased abdominal obesity. Women with polycystic ovary syndrome (PCOS) have an increased risk of developing metabolic syndrome over the course of their lives. Metabolic syndrome increases risk of major cardiovascular events, morbidity, quality of life, and overall health care costs. Though metabolic syndrome in women with PCOS is an area of great concern, there is no effective individual medical therapeutic to adequately treat this issue. This article will review key aspects of metabolic syndrome in PCOS. We will discuss classic and novel therapeutics to address metabolic syndrome in women with PCOS. We will conclude with the importance of developing strategic interventions to increase the compliance to lifestyle and dietary modification, in addition to appreciation of the emerging pharmaceutical therapeutics available. Innovation in lifestyle modification, including diet, exercise, with and without dedicated stress reduction techniques is the future in treatment of metabolic syndrome in PCOS. Application of novel interventions, such as group medical care, may improve future adherence to lifestyle modification recommendations, in addition to or in combination with pharmaceutical therapeutics.

Targets to treat metabolic syndrome in polycystic ovary syndrome

Science.gov (United States)

Mahalingaiah, Shruthi; Diamanti-Kandarakis, Evanthia

2016-01-01

Introduction Metabolic syndrome is comprised of a combination of the following states: increased insulin resistance, dyslipidemia, cardiovascular disease, and increased abdominal obesity. Women with polycystic ovary syndrome (PCOS) have an increased risk of developing metabolic syndrome over the course of their lives. Metabolic syndrome increases risk of major cardiovascular events, morbidity, quality of life, and overall health care costs. Though metabolic syndrome in women with PCOS is an area of great concern, there is no effective individual medical therapeutic to adequately treat this issue. Areas Covered This article will review key aspects of metabolic syndrome in PCOS. We will discuss classic and novel therapeutics to address metabolic syndrome in women with PCOS. We will conclude with the importance of developing strategic interventions to increase the compliance to lifestyle and dietary modification, in addition to appreciation of the emerging pharmaceutical therapeutics available. Expert Opinion Innovation in lifestyle modification, including diet, exercise, with and without dedicated stress reduction techniques is the future in treatment of metabolic syndrome in PCOS. Application of novel interventions, such as group medical care, may improve future adherence to lifestyle modification recommendations, in addition to or in combination with pharmaceutical therapeutics. PMID:26488852

The 2008 Wells, Nevada earthquake sequence: Source constraints using calibrated multiple event relocation and InSAR

Science.gov (United States)

Nealy, Jennifer; Benz, Harley M.; Hayes, Gavin; Berman, Eric; Barnhart, William

2017-01-01

The 2008 Wells, NV earthquake represents the largest domestic event in the conterminous U.S. outside of California since the October 1983 Borah Peak earthquake in southern Idaho. We present an improved catalog, magnitude complete to 1.6, of the foreshock-aftershock sequence, supplementing the current U.S. Geological Survey (USGS) Preliminary Determination of Epicenters (PDE) catalog with 1,928 well-located events. In order to create this catalog, both subspace and kurtosis detectors are used to obtain an initial set of earthquakes and associated locations. The latter are then calibrated through the implementation of the hypocentroidal decomposition method and relocated using the BayesLoc relocation technique. We additionally perform a finite fault slip analysis of the mainshock using InSAR observations. By combining the relocated sequence with the finite fault analysis, we show that the aftershocks occur primarily updip and along the southwestern edge of the zone of maximum slip. The aftershock locations illuminate areas of post-mainshock strain increase; aftershock depths, ranging from 5 to 16 km, are consistent with InSAR imaging, which shows that the Wells earthquake was a buried source with no observable near-surface offset.

Central Pain Syndrome

Science.gov (United States)

... such as neurontin (gabapentin) can be useful. Lowering stress levels appears to reduce pain. View Full Treatment Information Definition Central pain syndrome is a neurological condition caused ...

The negative effects of development megaprojects: Comparative study of four cases of population relocation related to dam projects

International Nuclear Information System (INIS)

D'Almeida, K.

1993-11-01

As with any other hydroelectric installation project around the world, the construction of large dams in Africa such as the Kariba in Zambia, the Aswan High Dam in Egypt, the Akossombo in Ghana, and the Kossou in Ivory Coast have caused massive displacements of populations. Parallel to the attendant positive effects, negative effects have been observed following the relocation of those populations. These negative effects are social, cultural, political, economic, sanitary, demographic, psychological, and ecological. A comparative study is conducted of the four cases of dam construction cited above in order to demonstrate that errors committed by planners were at the source of those negative effects of population displacement. The knowledge of those errors committed in the past should serve as lessons for future instances of population relocation. Such lessons are outlined in the areas of relocation planning, principles of indemnization, re-housing of populations on new sites, and adaptation of the populations to new agricultural techniques. 116 refs., 14 figs., 5 tabs

Effect of prolonged stress on the adrenal hormones of individuals with irritable bowel syndrome.

Science.gov (United States)

Sugaya, Nagisa; Izawa, Shuhei; Saito, Keisuke; Shirotsuki, Kentaro; Nomura, Shinobu; Shimada, Hironori

2015-01-01

The purpose of this study was to investigate the effect of prolonged stress on the salivary adrenal hormones (cortisol, dehydroepiandrosterone [DHEA], DHEA-sulfate [DHEA-S]) of individuals with irritable bowel syndrome (IBS). The participants were female college students, including 10 with IBS and 16 without IBS (control group), who were scheduled for a 2-week teaching practice at a kindergarten. Participants were asked to collect saliva for determining adrenal hormones immediately and 30 min after awakening and before sleep, 2 weeks before the practice, the first week of the practice, the second week of the practice, and a few days after the practice. Regarding cortisol/DHEA ratio, significantly increased levels were found during the first week of the practice, and a significant interaction between group and time was found; the ratio at 30 min after awakening in the IBS group was higher than that in the control group. For the other adrenal hormone indexes, no significant differences due to the presence of IBS were found. Individuals with IBS showed an elevated cortisol/DHEA ratio after awakening compared with individuals without IBS, and the elevated ratio peaked under the prolonged stress. The present study suggests that the cortisol effect is dominant in individuals with IBS under prolonged stress.

The relationships between family functioning and attachment orientations to post-traumatic stress symptoms among young adults who were evacuated from Gaza Strip settlements as adolescents.

Science.gov (United States)

Zerach, Gadi; Tam, Elkanor

2016-01-01

This study examined post-traumatic stress disorder (PTSD) symptoms among young adults that were evicted from their residences in Gaza settlements ("Gush Katif") as adolescents and actively participated in the resistance events. Furthermore, we examined the moderating role of exposure to forced relocation on the association between attachment orientations and family functioning and PTSD symptoms. We conducted a correlative, cross-sectional study in 2013. Participants were Israeli evicted residents (ER group; N = 102), comparison groups of evicted nonresidents (ENR group; N = 27), and nonevicted nonresidents (NENR group; N = 53). All participants completed a battery of self-reported questionnaires. The ER group reported a higher number of PTSD symptoms as compared to the comparison groups. However, ER participants did not differ from ENR and NENR participants in their perception of family functioning. Importantly, the group (ER vs. NENR) moderated the association between attachment-anxiety and PTSD symptoms and between family adaptability and PTSD symptoms. Nine years after the forced relocation from Gaza settlements, young adults that were evicted from their residences as adolescents suffer from PTSD symptoms that are more related to the relocation itself than the stress entailed in the resistance events.

41 CFR 302-2.2 - May I relocate to my new official duty station before I receive a written travel authorization (TA)?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false May I relocate to my new official duty station before I receive a written travel authorization (TA)? 302-2.2 Section 302-2.2 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES INTRODUCTION 2...

Preliminary evaluation of crisis-relocation fallout-shelter options. Volume 1. Summary

International Nuclear Information System (INIS)

Santini, D.J.; Clinch, J.M.; Davis, F.H.; Hill, L.G.; Lynch, E.P.; Tanzman, E.A.; Wernette, D.R.

1982-03-01

This report, prepared for the Federal Emergency Management Agency (FEMA), presents a summary evaluation of various shelter options for use in the case where the President orders crisis relocation of the US urban population because of strong expectation of a nuclear war. The availability of livable shelter space at 40 ft 2 per person (congregate-care space) by state is evaluated. Options are evaluated for construction of fallout shelters allowing 10 ft 2 per person - such shelters are designed to provide 100% survival at projected levels of radioactive fallout. The authors find that the FEMA concept of upgrading existing buildings to act as fallout shelters can, in principle, provide adequate shelter throughout most of the US. Exceptions are noted and remedies proposed. The authors also find that, in terms of upgrading existing buildings to fallout shelter status, great benefits are possible by turning away from a standard national approach and adopting a more site-specific approach. Existing FEMA research provides a solid foundation for successful crisis relocation planning, but the program can be refined by making suitable modifications in its locational, engineering, and institutionally specific elements

In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome.

Science.gov (United States)

Berkowitz, Bruce A; Lenning, Jacob; Khetarpal, Nikita; Tran, Catherine; Wu, Johnny Y; Berri, Ali M; Dernay, Kristin; Haacke, E Mark; Shafie-Khorassani, Fatema; Podolsky, Robert H; Gant, John C; Maimaiti, Shaniya; Thibault, Olivier; Murphy, Geoffrey G; Bennett, Brian M; Roberts, Robin

2017-09-01

Hippocampus oxidative stress is considered pathogenic in neurodegenerative diseases, such as Alzheimer disease (AD), and in neurodevelopmental disorders, such as Angelman syndrome (AS). Yet clinical benefits of antioxidant treatment for these diseases remain unclear because conventional imaging methods are unable to guide management of therapies in specific hippocampus subfields in vivo that underlie abnormal behavior. Excessive production of paramagnetic free radicals in nonhippocampus brain tissue can be measured in vivo as a greater-than-normal 1/ T 1 that is quenchable with antioxidant as measured by quench-assisted (Quest) MRI. Here, we further test this approach in phantoms, and we present proof-of-concept data in models of AD-like and AS hippocampus oxidative stress that also exhibit impaired spatial learning and memory. AD-like models showed an abnormal gradient along the CA1 dorsal-ventral axis of excessive free radical production as measured by Quest MRI, and redox-sensitive calcium dysregulation as measured by manganese-enhanced MRI and electrophysiology. In the AS model, abnormally high free radical levels were observed in dorsal and ventral CA1. Quest MRI is a promising in vivo paradigm for bridging brain subfield oxidative stress and behavior in animal models and in human patients to better manage antioxidant therapy in devastating neurodegenerative and neurodevelopmental diseases.-Berkowitz, B. A., Lenning, J., Khetarpal, N., Tran, C., Wu, J. Y., Berri, A. M., Dernay, K., Haacke, E. M., Shafie-Khorassani, F., Podolsky, R. H., Gant, J. C., Maimaiti, S., Thibault, O., Murphy, G. G., Bennett, B. M., Roberts, R. In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome. © FASEB.

A rat model of post-traumatic stress disorder reproduces the hippocampal deficits seen in the human syndrome

OpenAIRE

Goswami, Sonal; Samuel, Sherin; Sierra, Olga R.; Cascardi, Michele; Paré, Denis

2012-01-01

Despite recent progress, the causes and pathophysiology of post-traumatic stress disorder (PTSD) remain poorly understood, partly because of ethical limitations inherent to human studies. One approach to circumvent this obstacle is to study PTSD in a valid animal model of the human syndrome. In one such model, extreme and long-lasting behavioral manifestations of anxiety develop in a subset of Lewis rats after exposure to an intense predatory threat that mimics the type of life-and-death situ...

Navigating emotions and relationship dynamics: family life review as a clinical tool for older adults during a relocation transition into an assisted living facility.

Science.gov (United States)

O'Hora, Kendra A; Roberto, Karen A

2018-01-16

Relocation for the purpose of receiving care may be one of the more challenging transitions for older adults. The purpose of this study was to facilitate a family life review (FLR) session aimed at enhancing family relationships and assisting older adults in coping with the challenges associated with a relocation. Fourteen dyads comprised of older adults who relocated to an assisted living facility (ALF) and a chosen family member or friend participated in a FLR session and semi-structured follow up interview. Data were analyzed using the constant comparative method and triangulated with descriptive statistics. Emergent themes suggested participating in FLR influenced families by raising emotions, systemically thinking, and navigating the relocation. FLR facilitated positive connections, enhanced existing relationships, and promoted self-acceptance. Families indicated mutual storytelling was enjoyable and reminded them of the urgency to share their story. FLR allowed dyads to reflect and thus prompted a renewed perspective on some of the more challenging components of the relocation transition. Study findings provide insight into how families organize individual and interpersonal narratives and use these narratives during transitional times. FLR can aid families in making a smoother and fulfilling move to an ALF and other late life transitions.

[Syndrome of emotional burnout among women-physicians elderly].

Science.gov (United States)

Myakotnykh, V S; Borovkova, T A

2017-01-01

The article presents the results of a comparative study of clinical symptoms of syndrome of emotional burnout among 84 working in the specialty physician of older women and 48 officially ceasing operations in this specialty. The findings suggest that burnout can take place among representatives of older age and more it is continued, provided professional activities. The cessation of the work activities leads to stress, often with the subsequent development post-traumatic stress disorder and stress-induced diseases. However in this case the clinical symptoms of the syndrome of emotional burnout, does not disappear, but only happens their clinical transformation attach various psychosomatic disorders. Thus, the elderly, suffering the syndrome of emotional burnout, are at high risk group with regard to the formation and development of diseases, associated with stress and require close monitoring in the framework of the compulsory program of medical examination.

Relocation and the characteristics of hospital and hostel regimes.

Science.gov (United States)

Booth, T; Simons, K; Booth, W

1991-01-01

Drawing on evidence from a research evaluation of a local community care programme, this paper explores whether relocation from a British National Health Service mental handicap hospital into local authority hostels (supervised residential facilities) brought about a qualitative change in the residential environment of movers towards less restrictive management practices and caring routines, more responsive attitudes towards their rights and needs as individuals, and greater control over their own lives. The conclusions point to the existence of a substantial measure of overlap in the fundamental characteristics of the hospital and hostel regimes.

The relation between intensity and complexity of coronary artery lesion and oxidative stress in patients with acute coronary syndrome.

Science.gov (United States)

Turan, Turhan; Menteşe, Ümit; Ağaç, Mustafa Tarık; Akyüz, Ali Rıza; Kul, Selim; Aykan, Ahmet Çağrı; Bektaş, Hüseyin; Korkmaz, Levent; Öztaş Menteşe, Seda; Dursun, İhsan; Çelik, Şükrü

2015-10-01

Oxidative stress plays a major role in the development of atherosclerosis. However, the relationship between oxidative stress and complexity and intensity of coronary artery disease is less clear. The aim of this study is to assess the relationship between oxidative stress markers and the complexity and intensity of coronary artery disease in patients with acute coronary syndrome (ACS). Sixty-seven consecutive patients with an early phase of ACS (=22). Likewise patients were divided into two CAD severity groups according to the median Gensini score of 64: less intensive CAD with Gensini score (=64. Blood samples were taken in 1 hour within administration in order to measure total oxidative status (TOS) and total antioxidant capacity (TAC) levels determined by Erel method. Oxidative stress index (OSI) was calculated by TOS /TAC. There was no significant difference between the two SYNTAX groups for oxidative stress markers. Median TOS and OSI values were significantly high in the intensive CAD group (p=0.005, p=0.04, respectively). The Gensini score was positively correlated with TOS and OSI (p=0.003, p=0.02, respectively). Oxidative stress markers may be considered supportive laboratory parameters related to CAD intensity but not complexity in ACS patients.

Preliminary evaluation of crisis-relocation fallout-shelter options. Volume 2. Detailed analysis

Energy Technology Data Exchange (ETDEWEB)

Santini, D.J.; Clinch, J.M.; Davis, F.H.; Hill, L.G.; Lynch, E.P.; Tanzman, E.A.; Wernette, D.R.

1982-12-01

This report presents a preliminary, detailed evaluation of various shelter options for use if the President orders crisis relocation of the US urban population because of strong expectation of a nuclear war. The availability of livable shelter space at 40 ft/sup 2/ per person (congregate-care space) by state is evaluated. Options are evaluated for construction of fallout shelters allowing 10 ft/sup 2/ per person - such shelters are designed to provide 100% survival at projected levels of radioactive fallout. The FEMA concept of upgrading existing buildings to act as fallout shelters can, in principle, provide adequate shelter throughout most of the US. Exceptions are noted and remedies proposed. In terms of upgrading existing buildings to fallout shelter status, great benefits are possible by turning away from a standard national approach and adopting a more site-specific approach. Existing FEMA research provides a solid foundation for successful crisis relocation planning, but the program can be refined by making suitable modifications in its locational, engineering, and institutionally specific elements.

The fuel string relocation effect - why the Bruce reactors were derated

Energy Technology Data Exchange (ETDEWEB)

Gold, M; Farooqui, M Z; Adebiyi, A S; Chu, R Y; Le, N T; Oliva, A F [Ontario Hydro, Toronto, ON (Canada); Balog, G; Qu, T; DeBuda, P G [Ontario Hydro, Tiverton, ON (Canada). Bruce Nuclear Generating Station-A

1996-12-31

In the CANDU Safety Analysis process, a series of design basis accidents are chosen and analyzed to confirm safety system effectiveness. Of all the postulated accidents, the Large Break Loss of Coolant Accident (LBLOCA) - a postulated break in the Heat Transport System piping near a component that services a large number of fuel channels - sets the most demanding requirements on the speed and reactivity depth of the shutdown system devices - shutoff rods and liquid poison injection. While the event is extremely improbable, it is reanalyzed periodically and its consequences examined to ensure continued shutdown system effectiveness. In March 1993, an additional effect was identified: if the break occurred in the piping on the inlet side of the core, this would cause sudden movement of the fuel bundles (so-called fuel string relocation) in a large number of channels. In Ontario Hydro`s Bruce NGS A, Bruce NGS B and Darlington reactors, each channel is fuelled against the flow. In this situation, the relocation of the fuel string results in a sudden positive reactivity increase. This reactivity increase is in addition to the reactivity due to the core coolant voiding. The combined reactivity effect could lead to power pulses much higher than those that would arise due to coolant voiding alone. To maintain safety margins in the event of such a postulated accident, the eight Bruce NGS A and Bruce NGS B units were initially derated to 60 percent power within 2 days of the identification and confirmation of this effect. This paper: describes the fuel string relocation phenomenon in detail; explains why the consequences differ at the various Ontario Hydro reactors; outlines the actions taken with respect to each of the Ontario Hydro reactors in the months following March 1993; describes the design solutions implemented to mitigate the problem and return the Bruce reactors to higher powers. 6 refs., 1 tab., 6 figs.

24 CFR 1000.14 - What relocation and real property acquisition policies are applicable?

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false What relocation and real property acquisition policies are applicable? 1000.14 Section 1000.14 Housing and Urban Development Regulations... HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT NATIVE AMERICAN HOUSING ACTIVITIES General § 1000.14...

The Impact of DEM Resolution on Relocating Radar Altimetry Data Over Ice Sheets

DEFF Research Database (Denmark)

Fredenslund Levinsen, Joanna; Simonsen, Sebastian Bjerregaard; Sørensen, Louise Sandberg

2016-01-01

for correcting for such mispointing errors. Here, two techniques are applied to observations near Jakobshavn Isbræ, acquired with Envisat’s Radar Altimeter(RA-2). The apriori knowledge on the surface topography is obtained from a digital elevation model. The methods relocate the measurement location horizontally...

Stress fractures in military training

International Nuclear Information System (INIS)

Jofre, M.J.; Sierralta, M.P.

2002-01-01

During military training, the incidence of overuse injuries like stress fractures increase. The aim of the study was to investigate the utility of bone scan in a military population with clinical suspected stress fractures or periostitis. Material and methods: A three-year retrospective analysis was made on patients who were clinically diagnosed with stress fractures at the Military Hospital Nuclear Medicine Department. Thirty-seven patients were studied (mean age 23. +/- 8 y.o; 31 males), 28 cases of which (76%) had tibial stress syndrome. Other localizations were lumbar spine, femoral, fibular, tarsal or metatarsal. Bone scintigraphy was performed injecting 1036 MBq of Tc99m-MDP i.v. Whole body images and lateral projections of lower extremities were done. Results: Bone scan in tibial syndrome was positive for 23 cases (82%), 65% of them were bilateral and 13% also had femoral injuries. X-rays were done in 10 cases and were all negative. In other localizations, the bone scans were negative, but demonstrated other degenerative lesions. All stress fractures were conservatively treated with non-steroidal anti-inflammatories and suspension of physical activity. Conclusions: Bone scan is a reliable confirmatory tool for tibial stress syndrome diagnosis. In addition, it helps to determine both the severity and extension of the injury as well as support the indication of rest in the military population

Stress fractures in military training

Energy Technology Data Exchange (ETDEWEB)

Jofre, M J; Sierralta, M P [Military Hospital Nuclear Medicine Department, Santiago (Chile)

2002-09-01

During military training, the incidence of overuse injuries like stress fractures increase. The aim of the study was to investigate the utility of bone scan in a military population with clinical suspected stress fractures or periostitis. Material and methods: A three-year retrospective analysis was made on patients who were clinically diagnosed with stress fractures at the Military Hospital Nuclear Medicine Department. Thirty-seven patients were studied (mean age 23. +/- 8 y.o; 31 males), 28 cases of which (76%) had tibial stress syndrome. Other localizations were lumbar spine, femoral, fibular, tarsal or metatarsal. Bone scintigraphy was performed injecting 1036 MBq of Tc99m-MDP i.v. Whole body images and lateral projections of lower extremities were done. Results: Bone scan in tibial syndrome was positive for 23 cases (82%), 65% of them were bilateral and 13% also had femoral injuries. X-rays were done in 10 cases and were all negative. In other localizations, the bone scans were negative, but demonstrated other degenerative lesions. All stress fractures were conservatively treated with non-steroidal anti-inflammatories and suspension of physical activity. Conclusions: Bone scan is a reliable confirmatory tool for tibial stress syndrome diagnosis. In addition, it helps to determine both the severity and extension of the injury as well as support the indication of rest in the military population.

Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome.

Science.gov (United States)

Goldstein, Jill M; Holsen, Laura; Huang, Grace; Hammond, Bradley D; James-Todd, Tamarra; Cherkerzian, Sara; Hale, Taben M; Handa, Robert J

2016-12-01

Major depressive disorder (MDD) is the number one cause of disability worldwide and is comorbid with many chronic diseases, including obesity/metabolic syndrome (MetS). Women have twice as much risk for MDD and comorbidity with obesity/MetS as men, although pathways for understanding this association remain unclear. On the basis of clinical and preclinical studies, we argue that prenatal maternal stress (ie, excess glucocorticoid expression and associated immune responses) that occurs during the sexual differentiation of the fetal brain has sex-dependent effects on brain development within highly sexually dimorphic regions that regulate mood, stress, metabolic function, the autonomic nervous system, and the vasculature. Furthermore, these effects have lifelong consequences for shared sex-dependent risk of MDD and obesity/MetS. Thus, we propose that there are shared biologic substrates at the anatomical, molecular, and/or genetic levels that produce the comorbid risk for MDD-MetS through sex-dependent fetal origins.

Protective effect of epigallocatechin gallate in murine water-immersion stress model of chronic fatigue syndrome.

Science.gov (United States)

Sachdeva, Anand Kamal; Kuhad, Anurag; Tiwari, Vinod; Arora, Vipin; Chopra, Kanwaljit

2010-06-01

Chronic fatigue syndrome (CFS) is a specific clinical condition that characterizes unexplained disabling fatigue. In the present study, chronic fatigue was produced in mice by subjecting them to forced swim inside a rectangular jar of specific dimensions for 6 min. daily for 15 days. Epigallocatechin gallate (EGCG; 25, 50 and 100 mg/kg, p.o.) was administered daily 30 min. before forced swim session. Immobility period and post-swim fatigue was assessed on alternate days. On the 16th day, after assessment of various behavioural parameters, mice were killed to harvest the brain, spleen and thymus. There was significant increase in oxidative-nitrosative stress and tumour necrosis factor-alpha levels in the brain of mice subjected to water-immersion stress as compared with naive group. These behavioural and biochemical alterations were restored after chronic treatment with EGCG. The present study points out that EGCG could be of therapeutic potential in the treatment of chronic fatigue.

Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India

Directory of Open Access Journals (Sweden)

Veena S. Rao

2011-01-01

Full Text Available Metabolic syndrome (MetS is a primary risk factor for cardiovascular disease and is associated with a proinflammatory state. Here, we assessed the contribution of inflammatory and oxidative stress markers towards prediction of MetS. A total of 2316 individuals were recruited in Phase I of the Indian Atherosclerosis Research Study (IARS. Modified ATPIII guidelines were used for classification of subjects with MetS. Among the inflammatory and oxidative stress markers studied, levels of hsCRP (P<.0001, Neopterin (P=.036, and oxLDL (P<.0001 were significantly higher among subjects with MetS. Among the markers we tested, oxLDL stood out as a robust predictor of MetS in the IARS population (OR 4.956 95% CI 2.504–9.810; P<.0001 followed by hsCRP (OR 1.324 95% CI 1.070–1.638; P=.010. In conclusion, oxLDL is a candidate predictor for MetS in the Asian Indian population.

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Symptom Severity: Stress Management Skills are Related to Lower Illness Burden.

Science.gov (United States)

Lattie, Emily G; Antoni, Michael H; Fletcher, Mary Ann; Czaja, Sara; Perdomo, Dolores; Sala, Andreina; Nair, Sankaran; Fu, Shih Hua; Penedo, Frank J; Klimas, Nancy

2013-01-01

The onset of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) typically involves reductions in activities of daily living and social interactions (jointly referred to as "illness burden"). Emotional distress has been linked to increased reported symptoms, and stress management skills have been related to lower fatigue severity in CFS patients. Symptom severity and illness burden are highly correlated. The ability to manage stress may attenuate this relationship, allowing individuals to feel less burdened by the illness independent of the severity of their symptoms. This study aimed to evaluate if perceived stress management skills affect illness burden via emotional distress, independent of ME/CFS symptom severity. A total of 117 adults with ME/CFS completed measures of perceived stress management skills, emotional distress, ME/CFS symptom severity and illness burden. Regression analyses revealed that greater perceived stress management skills related to less social and fatigue-related illness burden, via lower emotional distress. This relationship existed independent of the association of symptom severity on illness burden, and was stronger among those not currently employed. Ability to manage stress is associated with a lower illness burden for individuals with ME/CFS. Future studies should evaluate the efficacy of psychosocial interventions in lowering illness burden by targeting stress management skills.

Effect of Ramadan Fasting on Stress Neurohormones in Women with Polycystic Ovary Syndrome.

Directory of Open Access Journals (Sweden)

Farideh Zangeneh

2015-06-01

Full Text Available To determine the effects of Ramadan fasting on serum levels of stress neurohormones in Iranian women with polycystic ovary syndrome (PCOS.This study was a clinical trial and was performed during July 2011 (month of Ramadan in Royan institute, Tehran. A total of 40 women who were aged 20-40 years and known cases of PCOS and had no other medical diseases were included in the study. They were divided into two groups as follows: (i study group (n = 20 who participated in Ramadan fasting and (ii control group (n = 20 who did not participate in fasting. For evaluating Ramadan's effect on the level of neurohormones serum level of the following variables were evaluated before and after Ramadan: cortisol, adrenaline (A, noradrenalin (NA, beta-endorphin (β-End, insulin, as well as sex hormones including follicle-stimulating hormone (FSH, luteinizing hormone (LH, and testosterone.In the study group after Ramadan serum cortisol and nor-adrenaline levels were significantly lower than the initial levels obtained at beginning of Ramadan (p < 0.05 as compared to control group.This study indicates that Ramadan fasting decreases stress neurohormones in women with PCOS.

The metabolic syndrome among Danish seafarers

DEFF Research Database (Denmark)

Jepsen, Jørgen Riis; Rasmussen, Hanna Barbara

2016-01-01

Background: The metabolic syndrome (MS) represents a cluster of risk factors related to insulin resistance. Metabolic syndrome is a strong risk factor for chronic metabolic and cardiovascular diseases and is related to nutritional factors, sleep patterns, work-related stress, fatigue, and physical...

78 FR 49359 - Pay Under the General Schedule and Recruitment, Relocation, and Retention Incentives

Science.gov (United States)

2013-08-14

.... Agencies may, in their agency retention incentive plans, require documentation of private-sector job offers... Schedule and Recruitment, Relocation, and Retention Incentives AGENCY: U.S. Office of Personnel Management... to improve oversight of recruitment and retention incentive determinations; add succession planning...

Rapid-relocation model for describing high-fluence retention of rare gases implanted in solids

Science.gov (United States)

Wittmaack, K.

2009-09-01

It has been known for a long time that the maximum areal density of inert gases that can be retained in solids after ion implantation is significantly lower than expected if sputter erosion were the only limiting factor. The difference can be explained in terms of the idea that the trapped gas atoms migrate towards the surface in a series of detrapping-trapping events so that reemission takes place well before the receding surface has advanced to the original depth of implantation. Here it is shown that the fluence dependent shift and shape of implantation profiles, previously determined by Rutherford backscattering spectrometry (RBS), can be reproduced surprisingly well by extending a simple retention model originally developed to account only for the effect of surface recession by sputtering ('sputter approximation'). The additional migration of inert gas atoms is formally included by introducing an effective shift parameter Yeff as the sum of the sputtering yield Y and a relocation efficiency Ψrel. The approach is discussed in detail for 145 keV Xe + implanted in Si at normal incidence. Yeff was found to increase with increasing fluence, to arrive at a maximum equivalent to about twice the sputtering yield. At the surface one needs to account for Xe depletion and the limited depth resolution of RBS. The (high-fluence) effect of implanted Xe on the range distributions is discussed on the basis of SRIM calculations for different definitions of the mean target density, including the case of volume expansion (swelling). To identify a 'range shortening' effect, the implanted gas atoms must be excluded from the definition of the depth scale. The impact-energy dependence of the relocation efficiency was derived from measured stationary Xe concentrations. Above some characteristic energy (˜20 keV for Ar, ˜200 keV for Xe), Y exceeds Ψrel. With decreasing energy, however, Ψrel increases rapidly. Below 2-3 keV more than 90% of the reemission of Ar and Xe is estimated

Clinician's perspectives of the relocation of a regional child and adolescent mental health service from co-located to stand alone premises.

Science.gov (United States)

Francis, K J; Boyd, C P; Sewell, J; Nurse, S

2008-01-01

Australia's National Mental Health Strategy's statement of rights and responsibilities states that children and adolescents admitted to a mental health facility or community program have the right to be separated from adult patients and provided with programs suited to their developmental needs. However, in rural Australia, where a lack of healthcare services, financial constraints, greater service delivery areas and fewer mental healthcare specialists represent the norm, Child and Adolescent Mental Health Services (CAMHS) are sometimes co-located with adult mental health services. The aim of the present study was to evaluate the impact of a recent relocation of a regional CAMHS in Victoria from co-located to stand alone premises. Six CAMHS clinicians who had experienced service delivery at a co-located setting and the current stand-alone CAMHS setting were interviewed about their perceptions of the impact of the relocation on service delivery. An exploratory interviewing methodology was utilized due to the lack of previous research in this area. Interview data were transcribed and analysed according to interpretative phenomenological analysis techniques. Findings indicated a perception that the relocation was positive for clients due to the family-friendly environment at the new setting and separation of CAMHS from adult psychiatric services. However, the impact of the relocation on clinicians was marked by a perceived loss of social capital from adult psychiatric service clinicians. These results provide increased understanding of the effects of service relocation and the influence of co-located versus stand-alone settings on mental health service delivery - an area where little prior research exists.

Public Housing Relocations and Relationships of Changes in Neighborhood Disadvantage and Transportation Access to Unmet Need for Medical Care.

Science.gov (United States)

Haley, Danielle F; Linton, Sabriya; Luo, Ruiyan; Hunter-Jones, Josalin; Adimora, Adaora A; Wingood, Gina M; Bonney, Loida; Ross, Zev; Cooper, Hannah L

2017-01-01

Cross-sectional research suggests that neighborhood characteristics and transportation access shape unmet need for medical care. This longitudinal analysis explores relationships of changes in neighborhood socioeconomic disadvantage and trans- portation access to unmet need for medical care. We analyzed seven waves of data from African American adults (N = 172) relocating from severely distressed public housing complexes in Atlanta, Georgia. Surveys yielded individual-level data and admin- istrative data characterized census tracts. We used hierarchical generalized linear models to explore relationships. Unmet need declined from 25% pre-relocation to 12% at Wave 7. Post-relocation reductions in neighborhood disadvantage were inversely associated with reductions in unmet need over time (OR = 0.71, 95% CI = 0.51-0.99). More frequent transportation barriers predicted unmet need (OR = 1.16, 95% CI = 1.02-1.31). These longitudinal findings support the importance of neighborhood environments and transportation access in shaping unmet need and suggest that improvements in these exposures reduce unmet need for medical care in this vulnerable population.

Freshwater mussel salvage and relocation at the Pond Eddy Bridge, Delaware River, New York and Pennsylvania

Science.gov (United States)

Galbraith, Heather S.; Blakeslee, Carrie J.; Cole, Jeffrey C.

2018-03-01

In a study conducted by the U.S. Geological Survey, in cooperation with the Pennsylvania Department of Transportation, freshwater mussels were salvaged and relocated from the anticipated zone of impact for the Pond Eddy Bridge construction project in New York and Pennsylvania. Five 25-meter (m) by 25-m cells along the Pennsylvania bank of the Delaware River were sampled in three generally straight-line passes by four surveyors wearing snorkel gear for a total of 180 survey minutes per cell. All mussels encountered were collected and identified to species. A subset of individuals was marked with shellfish tags, weighed, and measured prior to relocation upstream from the zone of impact. A total of 3,434 mussels, including 3,393 Elliptio complanata (eastern elliptio mussels), 39 Anodonta implicata (alewife floaters), 1 Strophitus undulatus (creeper), and 1 Pyganodon cataracta (eastern floater), were salvaged and relocated. All non-eastern elliptio species were georeferenced using a high-resolution global positioning system unit; a subset of tagged eastern elliptio was placed in transects between georeferenced points. These mussels will be monitored to assess the effects of translocation on mortality and body condition at 1 month, 1 year, and 2 years.

Effect of water stress on seedling growth in two species with different abundances: the importance of Stress Resistance Syndrome in seasonally dry tropical forest

Directory of Open Access Journals (Sweden)

Wanessa Nepomuceno Ferreira

2015-09-01

Full Text Available ABSTRACTIn seasonally dry tropical forests, species carrying attributes of Stress Resistance Syndrome (SRS may have ecological advantages over species demanding high quantities of resources. In such forests, Poincianella bracteosa is abundant, while Libidibia ferrea has low abundance; therefore, we hypothesized that P. bracteosa has characteristics of low-resource species, while L. ferrea has characteristics of high-resource species. To test this hypothesis, we assessed morphological and physiological traits of seedlings of these species under different water regimes (100%, 70%, 40%, and 10% field capacity over 85 days. For most of the studied variables we observed significant decreases with increasing water stress, and these reductions were greater in L. ferrea. As expected, L. ferreamaximized their growth with increased water supply, while P. bracteosa maintained slower growth and had minor adjustments in biomass allocation, characteristics representative of low-resource species that are less sensitive to stress. We observed that specific leaf area, biomass allocation to roots, and root/shoot ratio were higher in L. ferrea, while biomass allocation to leaves and photosynthesis were higher in P. bracteosa. Results suggest that the attributes of SRS can facilitate high abundance of P. bracteosa in dry forest.

Massage treatment and medial tibial stress syndrome; A commentary to provoke thought about the way massage therapy is used in the treatment of MTSS.

Science.gov (United States)

Fogarty, Sarah

2015-07-01

As students and practitioners we are taught about the treatment and causative factors of medial shin pain, in particular' shin splints' or the more recent term; medial tibial stress syndrome (MTSS). During the years there have been many theories, conjecture and misunderstandings about the mechanisms of 'shin splints/medial tibial stress syndrome' however the ramifications of these mechanisms on how massage treatment is delivered have not being discussed. The evidence for the treatment of MTSS is largely clinical with little evidence of any treatment being proven to be effective in treating MTSS. The aim of this article is to present a summary of the mechanisms of MTSS and a commentary to provoke thought about the way massage therapy is used in the treatment of MTSS based on these mechanisms. Copyright © 2014 Elsevier Ltd. All rights reserved.

Aerobic exercise modulation of mental stress-induced responses in cultured endothelial progenitor cells from healthy and metabolic syndrome subjects.

Science.gov (United States)

Rocha, Natalia G; Sales, Allan R K; Miranda, Renan L; Silva, Mayra S; Silva, Jemima F R; Silva, Bruno M; Santos, Aline A; Nóbrega, Antonio C L

2015-02-15

Numerous studies have demonstrated that exercise acutely prevents the reduction in flow-mediated dilation induced by mental stress in subjects with metabolic syndrome (MetS). However, it is unknown whether a similar effect occurs in endothelial progenitors cells (EPCs). This study investigated whether exercise protects from the deleterious effect of mental stress on cultured EPCs in healthy subjects and those with MetS. Ten healthy subjects (aged 31±2) and ten subjects with MetS (aged 36±2) were enrolled. Subjects underwent a mental stress test, followed immediately by either 40 min of leg cycling or rest across two randomized sessions: mental stress+non-exercise control (MS) and mental stress+exercise (MS+EXE). The Stroop Color-Word Test was used to elicit mental stress. Blood samples were drawn at baseline and following sessions to isolate mononuclear cells. These cells were cultured in fibronectin-coated plates for seven days, and EPCs were identified by immunofluorescence (acLDL(+)/ UEA-I Lectin(+)). All subjects presented similar increases in mean blood pressure and heart rate during the mental stress test (P0.05). The EPC response to MS and MS+EXE was increased in healthy subjects, whereas it was decreased in subjects with MetS (Pexercise session increased EPCs in healthy subjects but did not prevent the EPC reduction induced by mental stress among subjects with MetS. © 2015.

From the SEM (IAEA) to the SIMS (ITU): Re-location experiment of μm-size particles - first results

International Nuclear Information System (INIS)

Admon, U.; Donohue, D.; Aigner, H.; Tamborini, G.; Bildstein, O.; Betti, M.

2002-01-01

Full text: Nuclear forensic analysis of individual radioactive particles in the μm-size range can be performed in two steps: in the first, an automated SEM screening of the loaded sample holder, particles of interest (POIs) are located and classified according to their elemental composition and size. In the second, the sample is transferred to a mass spectrometer (usually a SIMS), and individual POIs are re-located and further analyzed for their isotopic composition. Alternatively, selected POIs can be extracted after SEM screening or fission track analysis, and then analyzed in a TIMS or ICPMS. In the SIMS, which has imaging capability of its own, the whole sample is manipulated to bring specific POIs to the ion-beam point of impingement. In all these cases, including re-visiting POIs in the SEM itself, a precise relocation method is essential. The re-location of POIs in the SIMS after they have been identified as such in the SEM is based on the triangulation method. A set of reference marks are 'printed' by vacuum-deposition of metallic thin-film patterns on the sample holder, a flat-polished graphite planchet. These marks, easily recognizable and precisely measurable by both instruments, serve as inherent coordinate system for each sample. The SEM screening provides a list of POIs, each with a data profile comprising stage coordinates, composition, and size. Having measured the stage coordinates of at least 3 linearly-independent reference marks in the SEM and in the SIMS allows predicting the SIMS stage coordinates where the POIs can be found. This paper describes a joint IAEA-ITU experiment aimed at testing the feasibility of the relocation method in two separate laboratories. A flat-polished graphite planchet was loaded with a small number (a few hundreds) of μm-size uranium particles using the NIST method [3] in the ITU clean laboratory. The sample was sent to the IAEA clean laboratory, where the reference marks pattern was 'printed' by vacuum

75 FR 22805 - Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection of...

Science.gov (United States)

2010-04-30

... GENERAL SERVICES ADMINISTRATION [Proposed GSA Bulletin FTR 10-XXX; Docket 2010-0009; Sequence 1] Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection of Transaction... GSA is posting online a proposed FTR bulletin that contains the data dictionary that large Federal...

Are Gasoline Prices a Factor in Residential Relocation Decisions? Preliminary Findings from the American Housing Survey, 1996–2008

Science.gov (United States)

Chi, Guangqing; Boydstun, Jamie

2018-01-01

Residential relocation choice is affected by numerous factors, but gasoline prices as a potential factor have not been investigated. This study examines gasoline price changes and residential relocation choice using 1996–2008 American Housing Survey data. We found higher gasoline prices are associated with a higher percentage of movers choosing locations closer to workplaces. The findings have implications for addressing the impacts of volatile gasoline prices on land use planning and policies; resilient “smart cities or communities” are one possible solution. PMID:29658959

Stress-Induced Visceral Pain: Toward Animal Models of Irritable-Bowel Syndrome and Associated Comorbidities

Science.gov (United States)

Moloney, Rachel D.; O’Mahony, Siobhain M.; Dinan, Timothy G.; Cryan, John F.

2015-01-01

Visceral pain is a global term used to describe pain originating from the internal organs, which is distinct from somatic pain. It is a hallmark of functional gastrointestinal disorders such as irritable-bowel syndrome (IBS). Currently, the treatment strategies targeting visceral pain are unsatisfactory, with development of novel therapeutics hindered by a lack of detailed knowledge of the underlying mechanisms. Stress has long been implicated in the pathophysiology of visceral pain in both preclinical and clinical studies. Here, we discuss the complex etiology of visceral pain reviewing our current understanding in the context of the role of stress, gender, gut microbiota alterations, and immune functioning. Furthermore, we review the role of glutamate, GABA, and epigenetic mechanisms as possible therapeutic strategies for the treatment of visceral pain for which there is an unmet medical need. Moreover, we discuss the most widely described rodent models used to model visceral pain in the preclinical setting. The theory behind, and application of, animal models is key for both the understanding of underlying mechanisms and design of future therapeutic interventions. Taken together, it is apparent that stress-induced visceral pain and its psychiatric comorbidities, as typified by IBS, has a multifaceted etiology. Moreover, treatment strategies still lag far behind when compared to other pain modalities. The development of novel, effective, and specific therapeutics for the treatment of visceral pain has never been more pertinent. PMID:25762939

Psychosocial risk factors for the metabolic syndrome

DEFF Research Database (Denmark)

Pedersen, Jolene Masters; Lund, Rikke; Andersen, Ingelise

2016-01-01

Background/Objectives: Metabolic deregulations and development of metabolic syndrome may be an important pathway underlying the relationship between stress and cardiovascular disease. We aim to estimate the effect of a comprehensive range of psychosocial factors on the risk of developing metabolic.......11) to be risk factors for developing the metabolic syndrome in women, while vital exhaustion (OR 2.09, 95% CI 0.95 to 4.59) and intake of sleep medications (OR 2.54, 95% CI 0.92 to 5.96) may play a more important role in men. Conclusions: Experiencing major life events in work and adult life and....../or dysfunctional social networks is a risk factor for metabolic syndrome in women, and stress reactions such as vital exhaustion and intake of sleep medications may play a more important role in the development of metabolic syndrome men....

The appraisal of chronic stress and the development of the metabolic syndrome: a systematic review of prospective cohort studies

Science.gov (United States)

Bergmann, N; Gyntelberg, F; Faber, J

2014-01-01

Chronic psychosocial stress has been proposed as a risk factor for the development of the metabolic syndrome (MES). This review gives a systematic overview of prospective cohort studies investigating chronic psychosocial stress as a risk factor for incident MES and the individual elements of MES. Thirty-nine studies were included. An association between chronic psychosocial stress and the development of MES was generally supported. Regarding the four elements of MES: i) weight gain: the prospective studies supported etiological roles for relationship stress, perceived stress, and distress, while the studies on work-related stress (WS) showed conflicting results; ii) dyslipidemi: too few studies on psychosocial stress as a risk factor for dyslipidemia were available to draw a conclusion; however, a trend toward a positive association was present; iii) type 2 diabetes mellitus (DM2): prospective studies supported perceived stress and distress as risk factors for the development of DM2 among men, but not among women, while WS was generally not supported as a risk factor among neither men nor women; iv) hypertension: marital stress and perceived stress might have an influence on blood pressure (BP), while no association was found regarding distress. Evaluating WS the results were equivocal and indicated that different types of WS affected the BP differently between men and women. In conclusion, a longitudinal association between chronic psychosocial stress and the development of MES seems present. However, the number of studies with sufficient quality is limited and the design of the studies is substantially heterogeneous. PMID:24743684

The Effects of Depression and Stressful Life Events on the Development and Maintenance of Syndromal Social Anxiety: Sex and Age Differences

Science.gov (United States)

Aune, Tore; Stiles, Tore C.

2009-01-01

This study assessed age and sex differences in the prevalence and incidence rates of syndromal social anxiety (SSA), as well as the predictive role of depressive symptoms and stressful life events on the development and persistence of SSA. A sample of 1,439 young people, between 11 and 14 years of age, was assessed twice within a 12-month…

Settlement Relocation Modeling: Reacting to Merapi’s Eruption Incident

Science.gov (United States)

Pramitasari, A.; Buchori, I.

2018-02-01

Merapi eruption has made severe damages in Central Java Province. Klaten was one of the most affected area, specifically in Balerante Village. This research is made to comprehend GIS model on finding alternative locations for impacted settlement in hazardous zones of eruption. The principal objective of the research study is to identify and analyze physical condition, community characteristics, and local government regulation related to settlements relocation plan for impacted area of eruption. The output is location map which classified into four categories, i.e. not available, available with low accessibility, available with medium accessibility, and available with high accessibility.

(Re)locating the gay Filipino: resistance, postcolonialism, and identity.

Science.gov (United States)

Manalansan, M F

1993-01-01

This paper attempts to critically analyze issues of postcolonial displacement, immigration, and homosexuality by examining the works of two Filipino gay immigrant writers, John Silva and Ralph Peña. Using postcolonial and critical theories, anthropological studies, and ethnographic fieldwork in New York City, this paper focuses on the role of language, memory, the body, race/ethnicity, and social class in the narrative strategies of the two writers. This paper argues that gay postcolonial writers such as these two relocate and reconfigure homosexual/gay identity in the face of new and oppressive hierarchies, identities, and practices.

Fenton's syndrome

International Nuclear Information System (INIS)

Rimondi, E.; Albasini, V.

1989-01-01

The authors report two recent cases of Fenton's syndrome, a very rare carpal fracture-dislocation. After some anatomophysiopathological considerations and a review of the literature, a wider nosographic frame is proposed in which the entity of the dislocation of the head of capitate bone is not essential. According to both the literature and personal findings, the authors remark that this syndrome is always found in the presence of two morphological variants of the distal radioulnar joint. Finally, the authors stress the importance of a corect diagnosis of this lesion to avoid unnecessary attempts of reduction

The role of endoplasmic reticulum stress in hippocampal insulin resistance.

Science.gov (United States)

Sims-Robinson, Catrina; Bakeman, Anna; Glasser, Rebecca; Boggs, Janet; Pacut, Crystal; Feldman, Eva L

2016-03-01

Metabolic syndrome, which includes hypertension, hyperglycemia, obesity, insulin resistance, and dyslipidemia, has a negative impact on cognitive health. Endoplasmic reticulum (ER) stress is activated during metabolic syndrome, however it is not known which factor associated with metabolic syndrome contributes to this stress. ER stress has been reported to play a role in the development of insulin resistance in peripheral tissues. The role of ER stress in the development of insulin resistance in hippocampal neurons is not known. In the current study, we investigated ER stress in the hippocampus of 3 different mouse models of metabolic syndrome: the C57BL6 mouse on a high fat (HF) diet; apolipoprotein E, leptin, and apolipoprotein B-48 deficient (ApoE 3KO) mice; and the low density lipoprotein receptor, leptin, and apolipoprotein B-48 deficient (LDLR 3KO) mice. We demonstrate that ER stress is activated in the hippocampus of HF mice, and for the first time, in ApoE 3KO mice, but not LDLR 3KO mice. The HF and ApoE 3KO mice are hyperglycemic; however, the LDLR 3KO mice have normal glycemia. This suggests that hyperglycemia may play a role in the activation of ER stress in the hippocampus. Similarly, we also demonstrate that impaired insulin signaling is only present in the HF and ApoE 3KO mice, which suggests that ER stress may play a role in insulin resistance in the hippocampus. To confirm this we pharmacologically induced ER stress with thapsigargin in human hippocampal neurons. We demonstrate for the first time that thapsigargin leads to ER stress and impaired insulin signaling in human hippocampal neurons. Our results may provide a potential mechanism that links metabolic syndrome and cognitive health. Copyright © 2016 Elsevier Inc. All rights reserved.

75 FR 42691 - Small Takes of Marine Mammals Incidental to Specified Activities; Exploratorium Relocation...

Science.gov (United States)

2010-07-22

... application from the Exploratorium, a nature, science, art and technology museum, requesting an IHA for the... (Eschrichtius robustus) incidental to relocation of the Exploratorium museum. Upon receipt of additional... function of current and device effectiveness (Caltrans, 2009). Therefore, distances to the Level A and...

Work ability index, absenteeism and depression among patients with burnout syndrome.

Science.gov (United States)

Pranjic, Nurka; Males-Bilic, Ljiljana

2014-08-01

The aim of this study is to estimate the association of burnout syndrome and depression; burnout syndrome and sick leave; and burnout syndrome with Work Ability Index in patients who suffer from stress at work. The control clinical study was conducted in the Teaching Department for Professional Pathology and Toxicology at the Primary Health Care Center Tuzla in the period from 2009 to 2014. The study included 140 patients exposed to different levels of stress at work. Besides conducted interviews and anamnesis with working anamnesis, physical examination, all patients were subjected to diagnostic package of questionnaires for assessing exposure to stress at work and its effects on health and work ability and Hamilton Rating Scale for screening depression. All patients were referred to the Department with suspected distress and burnout syndrome. For this study we used a questionnaire for measuring intensity of burnout (two categories exclude suffering from burnout syndrome: successfully overcome stress at work and sometimes feel stress at work and the other two reveal the initial and very high burn-out syndrome. Studied group was consisted of patients categorized with burnout syndrome (n=88). The questionnaire on the Work Ability Index (WAI) estimated characteristics of sick leave and prognostic factors with current work ability index. Lack of support at work with poor personal relations is the most common factor with the mobbing in burnout syndrome. Significantly more patients with the burnout syndrome suffered very severe depression 49%:37%; more use long sick leaves 53%:21%; several of them have poor WAI 51%:31% compared to those who are only exposed to stress at work (p=0.001). We found that the burn-out syndrome is predictor for developing depression (β=0.312, 95% CI, 0.114-0.353, p=0.001); absenteeism (β=0.285, 95% CI, 0.093-0.334, p=0.001); and a decline in working ability (β=0.413, 95% CI, 0.297-0.648). All the patients in whom it is found burnout

Longitudinal relationship of diet and oxidative stress with depressive symptoms in patients with metabolic syndrome after following a weight loss treatment: the RESMENA project.

Science.gov (United States)

Perez-Cornago, Aurora; Lopez-Legarrea, Patricia; de la Iglesia, Rocio; Lahortiga, Francisca; Martinez, J Alfredo; Zulet, M Angeles

2014-12-01

Metabolic syndrome and depression seem to share some common underlying mechanisms, although less is known about the impact of metabolic syndrome dietary treatments on depression. This study examined the association between a hypocaloric treatment designed to reduce metabolic syndrome features in self-perceived depression and the potential involvement of dietary components and oxidative stress changes. Analyses were based on volunteers (n = 55) with metabolic syndrome (age 50 ± 1 y.o.; 38M/17F), where depressive symptoms were assessed using the Beck Depression Inventory. Participants followed two hypocaloric diets (control diet and RESMENA diet) with the same energy restriction (-30% TCV) for six months. Depressive symptoms, dietary records, anthropometrical measurements, biochemical parameters and oxidative stress levels were analysed. Both diets improved self-perceived depression similarly (p = 0.528). Participants with lower depressive symptoms at baseline reported a significantly higher intake of omega-3 polyunsaturated fatty acids (p trend = 0.002). Interestingly, after adjusting for potential confounders, the increase in folate consumption (p = 0.011) and the decrease in plasma malondialdehyde levels (p = 0.012) throughout the intervention, were associated with the improvement in depressive symptoms. A higher intake of folate and a decline in malondialdehyde plasma levels during a weight loss intervention, were related to improvements in manifestations of depression (www.clinicaltrials.gov; NCT01087086). Copyright © 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

76 FR 1096 - Pay Under the General Schedule and Recruitment, Relocation, and Retention Incentives

Science.gov (United States)

2011-01-07

... RIN 3206-AM13 Pay Under the General Schedule and Recruitment, Relocation, and Retention Incentives... instructions for submitting comments. Mail: Jerome D. Mikowicz, Deputy Associate Director, Pay and Leave...-0824; or by e-mail at pay[email protected] . SUPPLEMENTARY INFORMATION: The U.S. Office of...

Characteristics of Relocated Quiet Zones Using Virtual Microphone Algorithm in an Active Headrest System

Directory of Open Access Journals (Sweden)

Seokhoon Ryu

2016-01-01

Full Text Available This study displays theoretical and experimental investigation on the characteristics of the relocated zone of quiet by a virtual microphone (VM based filtered-x LMS (FxLMS algorithm which can be embedded in a real-time digital controller for an active headrest system. The attenuation changes at the relocated zones of quiet by the variation of the distance between the ear and the error microphone are mainly examined. An active headrest system was implemented for the control experiment at a chair and consists of two (left and right secondary loudspeakers, two error microphones, two observer microphones at ear positions in a HATS, and other electronics including a dSPACE 1401 controller. The VM based FxLMS algorithm achieved an attenuation of about 22 dB in the control experiment against a narrowband primary noise by the variation of the distance between the ear and the error microphone. The important factors for the algorithm are discussed as well.

MEB 2013, Regulation for Administrator Assignment and Relocation Based On the Opinions of Administrators

Directory of Open Access Journals (Sweden)

Soner DOĞAN

2014-04-01

Full Text Available In this study; it is aimed to determine the opinions of the institution managers concerning the Regulation for Administrator Assignment and Relocation dated February 28, 2013, the scoring criteria in the regulation and the disturbances experienced in the application process of the regulation. The study is carried out in accordance with the phenomenological pattern through qualitative research methods. The participants were determined with the criterion sampling method which is one of the purposeful sampling methods. The study group of the research is composed of the eight managers serving in a province. In the study, a semi-structured interview form was used as data collection tool. In the interpretation process of the interviews, the inductive descriptive analysis, the content analysis and the constant comparison technique were used. Three main themes have come out regarding the result of the data analysis process of assigning the administrators, the combining of the different types of institutions and the application of the forced relocation.

BURNOUT SYNDROME AMONG EDUCATORS IN PRE-SCHOOL INSTITUTIONS.

Science.gov (United States)

Hozo, Endica Radic; Sucic, Goran; Zaja, Ivan

2015-12-01

The occurrence of burnout syndrome (BS) has been recognized in many professions (pilots, firefighters, police officers, doctors…) that during their work are subjected to high levels of stress. For educators in preschool institutions stress level is very high thus creating the possibility of developing BS. For this research is selected preschool institution - kindergarten "Radost" (Joy) in Split, in which by use of questionnaires (modified scale by Freudenberger and modified scales by Girdin, Everly and Dusek) during 2014 among educators (100 respondents) is conducted a survey regarding the frequency of burnout syndrome. According to questionnaires by Girdin, Everly and Dusek there is no statistically significant difference between the number of educators who feel good and those that are under significant stress (χ2=1.04; p=0.307). According to questionnaire by Freudenberg educators are classified into 3 categories and distribution of educators by the groups is almost uniform (χ2=2.76; p=0.250), which means that one third of a teacher is in good condition, a third is in the risk area for burn-out syndrome, while one third are candidates for development of this syndrome. Comparing a teacher in good condition compared to other (at risk and those who are candidates for the burn-out syndrome) is up to 1.5 times higher in those who are at risk and the candidates for development of this syndrome than in others (χ2=4.5; p=0.033). The occurrence of burnout syndrome is very high for the group of educators (half of the educators!) in pre-school institutions which should be taken into account by the institutions management. For this purpose, it is necessary to organize regular medical check-ups with particular reference to burnout syndrome with signs of the syndrome to prevent its further development.

BURNOUT SYNDROME AMONG EDUCATORS IN PRE-SCHOOL INSTITUTIONS

Science.gov (United States)

Hozo, Endica Radic; Sucic, Goran; Zaja, Ivan

2015-01-01

Introduction: The occurrence of burnout syndrome (BS) has been recognized in many professions (pilots, firefighters, police officers, doctors…) that during their work are subjected to high levels of stress. For educators in preschool institutions stress level is very high thus creating the possibility of developing BS. Material and methods: For this research is selected preschool institution – kindergarten „Radost” (Joy) in Split, in which by use of questionnaires (modified scale by Freudenberger and modified scales by Girdin, Everly and Dusek) during 2014 among educators (100 respondents) is conducted a survey regarding the frequency of burnout syndrome. Research results: According to questionnaires by Girdin, Everly and Dusek there is no statistically significant difference between the number of educators who feel good and those that are under significant stress (χ2=1.04; p=0.307). According to questionnaire by Freudenberg educators are classified into 3 categories and distribution of educators by the groups is almost uniform (χ2=2.76; p=0.250), which means that one third of a teacher is in good condition, a third is in the risk area for burn-out syndrome, while one third are candidates for development of this syndrome. Comparing a teacher in good condition compared to other (at risk and those who are candidates for the burn-out syndrome) is up to 1.5 times higher in those who are at risk and the candidates for development of this syndrome than in others (χ2=4.5; p=0.033). Conclusion: The occurrence of burnout syndrome is very high for the group of educators (half of the educators!) in pre-school institutions which should be taken into account by the institutions management. For this purpose, it is necessary to organize regular medical check-ups with particular reference to burnout syndrome with signs of the syndrome to prevent its further development. PMID:26889099

MARTINS: A foam/film flow model for molten material relocation in HWRs with U-Al-fueled multi-tube assemblies

International Nuclear Information System (INIS)

Kalimullah.

1994-01-01

Some special purpose heavy-water reactors (EM) are made of assemblies consisting of a number of coaxial aluminum-clad U-Al alloy fuel tubes and an outer Al sleeve surrounding the fuel tubes. The heavy water coolant flows in the annular gaps between the circular tubes. Analysis of severe accidents in such reactors requires a model for predicting the behavior of the fuel tubes as they melt and disrupt. This paper describes a detailed, mechanistic model for fuel tube heatup, melting, freezing, and molten material relocation, called MARTINS (Melting and Relocation of Tubes in Nuclear subassembly). The paper presents the modeling of the phenomena in MARTINS, and an application of the model to analysis of a reactivity insertion accident. Some models are being developed to compute gradual downward relocation of molten material at decay-heat power levels via candling along intact tubes, neglecting coolant vapor hydrodynamic forces on molten material. These models are inadequate for high power accident sequences involving significant hydrodynamic forces. These forces are included in MARTINS

Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories.

Directory of Open Access Journals (Sweden)

Luca Crepaldi

Full Text Available In neurons, the timely and accurate expression of genes in response to synaptic activity relies on the interplay between epigenetic modifications of histones, recruitment of regulatory proteins to chromatin and changes to nuclear structure. To identify genes and regulatory elements responsive to synaptic activation in vivo, we performed a genome-wide ChIPseq analysis of acetylated histone H3 using somatosensory cortex of mice exposed to novel enriched environmental (NEE conditions. We discovered that Short Interspersed Elements (SINEs located distal to promoters of activity-dependent genes became acetylated following exposure to NEE and were bound by the general transcription factor TFIIIC. Importantly, under depolarizing conditions, inducible genes relocated to transcription factories (TFs, and this event was controlled by TFIIIC. Silencing of the TFIIIC subunit Gtf3c5 in non-stimulated neurons induced uncontrolled relocation to TFs and transcription of activity-dependent genes. Remarkably, in cortical neurons, silencing of Gtf3c5 mimicked the effects of chronic depolarization, inducing a dramatic increase of both dendritic length and branching. These findings reveal a novel and essential regulatory function of both SINEs and TFIIIC in mediating gene relocation and transcription. They also suggest that TFIIIC may regulate the rearrangement of nuclear architecture, allowing the coordinated expression of activity-dependent neuronal genes.

Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories.

Science.gov (United States)

Crepaldi, Luca; Policarpi, Cristina; Coatti, Alessandro; Sherlock, William T; Jongbloets, Bart C; Down, Thomas A; Riccio, Antonella

2013-01-01

In neurons, the timely and accurate expression of genes in response to synaptic activity relies on the interplay between epigenetic modifications of histones, recruitment of regulatory proteins to chromatin and changes to nuclear structure. To identify genes and regulatory elements responsive to synaptic activation in vivo, we performed a genome-wide ChIPseq analysis of acetylated histone H3 using somatosensory cortex of mice exposed to novel enriched environmental (NEE) conditions. We discovered that Short Interspersed Elements (SINEs) located distal to promoters of activity-dependent genes became acetylated following exposure to NEE and were bound by the general transcription factor TFIIIC. Importantly, under depolarizing conditions, inducible genes relocated to transcription factories (TFs), and this event was controlled by TFIIIC. Silencing of the TFIIIC subunit Gtf3c5 in non-stimulated neurons induced uncontrolled relocation to TFs and transcription of activity-dependent genes. Remarkably, in cortical neurons, silencing of Gtf3c5 mimicked the effects of chronic depolarization, inducing a dramatic increase of both dendritic length and branching. These findings reveal a novel and essential regulatory function of both SINEs and TFIIIC in mediating gene relocation and transcription. They also suggest that TFIIIC may regulate the rearrangement of nuclear architecture, allowing the coordinated expression of activity-dependent neuronal genes.

Relation between burnout syndrome and job satisfaction among mental health workers.

Science.gov (United States)

Ogresta, Jelena; Rusac, Silvia; Zorec, Lea

2008-06-01

To identify predictors of burnout syndrome, such as job satisfaction and manifestations of occupational stress, in mental health workers. The study included a snowball sample of 174 mental health workers in Croatia. The following measurement instruments were used: Maslach Burnout Inventory, Manifestations of Occupational Stress Survey, and Job Satisfaction Survey. We correlated dimensions of burnout syndrome with job satisfaction and manifestations of occupational stress dimensions. We also performed multiple regression analysis using three dimensions of burnout syndrome--emotional exhaustion, depersonalization, and personal accomplishment. Stepwise multiple regression analysis showed that pay and rewards satisfaction (beta=-0.37), work climate (beta=-0.18), advancement opportunities (beta=0.17), the degree of psychological (beta=0.41), and physical manifestations of occupational stress (beta=0.29) were significant predictors of emotional exhaustion (R=0.76; F=30.02; Ppay and rewards satisfaction (beta=0.22) were significant predictors of depersonalization (R=0.57; F=13,01; PSatisfaction with the work climate (beta=-0.20) was a significant predictor of lower levels of personal accomplishment (R=0.20; F=5.06; Pjob satisfaction and manifestations of occupational stress proved to be relevant predictors of burnout syndrome.

Analysis of fuel relocation for the NRC/PNL Halden assemblies IFA-431, IFA-432, and IFA-513. Interim report

International Nuclear Information System (INIS)

Williford, R.E.; Mohr, C.L.; Lanning, D.D.; Cunningham, M.E.; Rausch, W.N.

1980-06-01

The effects of the thermally-induced cracking and subsequent relocation of UO2 fuel pellets on the thermal and mechanical behavior of light-water reactor fuel rods during irradiation are quantified in this report. Data from the Nuclear Regulatory Commission/Pacific Northwest Laboratory Halden experiments on instrumented fuel assemblies (IFA) IFA-431, IFA-432, and IFA-513 are analyzed. Beginning-of-life in-reactor measurements of fuel center temperatures, linear heat ratings, and cladding axial elongations are used in a new model to solve for the effective thermal conductivity and elastic moduli of the cracked fuel column. The primary assumptions of the new model are that (1) the cracked fuel is in a hydrostatic state of stress in the (r,theta) plane, and that (2) there is no axial slipping between fuel and cladding. Three basic parameters are used to describe the cracked fuel: (1) the crack pattern, (2) the crack roughness, and (3) the fuel surface (gap) roughness. Recommendations are made on refining the model

Molten material relocation into the lower plenum: a status report

International Nuclear Information System (INIS)

1998-09-01

This report, prepared by the task group 'Degraded Core Cooling' (DCC) for the CSNI, summarizes the experimental and theoretical knowledge of molten material relocation from a degraded core to the lower plenum of the reactor vessel under the main severe accident scenarios envisaged for both PWRs and BWRs, and boundary conditions. Consequences of movement of material to the lower head are considered with respect to the potential for reactor pressure vessel failure. The following models are reviewed: SCDAP/RELAP5, ICARE/CATHARE, ATHLET-CD/KESS, MELCOR, MAAP4, ESCADRE, etc.

Coulomb stress analysis of the 21 February 2008 Mw= 6.0 Wells, Nevada, earthquake

Science.gov (United States)

Sevilgen, Volkan

2011-01-01

Static Coulomb stress changes imparted by the February 21, 2008 Wells, Nevada earthquake are calculated, using an 8 x 6 km rectangular patch with a uniform slip as a source fault. Stress changes are resolved on nearby active faults using their rake, dip, and strike direction, assuming a fault friction of 0.4. The largest Coulomb stress increase (0.2 bars) imparted to surrounding major active faults from the Wells earthquake occurs on the Clover Hill fault, which may be the southern continuation of the ruptured fault. A 0.1 bar Coulomb stress increase is calculated on the western Snake Mountains fault. Coulomb stress decreases of 0.5 bars are calculated for the northern parts of the Independence and Ruby Mountains faults. The Coulomb stress change is calculated on relocated aftershocks assuming that they have the same strike, dip, and rake, as the source fault. Under this assumption, 75% of the aftershocks received a Coulomb stress increase.

Roles of Oxidative Stress in Polycystic Ovary Syndrome and Cancers

Directory of Open Access Journals (Sweden)

Tao Zuo

2016-01-01

Full Text Available Oxidative stress (OS has received extensive attention in the last two decades, because of the discovery that abnormal oxidation status was related to patients with chronic diseases, such as diabetes, cardiovascular, polycystic ovary syndrome (PCOS, cancer, and neurological diseases. OS is considered as a potential inducing factor in the pathogenesis of PCOS, which is one of the most common complex endocrine disorders and a leading cause of female infertility, affecting 4%–12% of women in the world, as OS has close interactions with PCOS characteristics, just as insulin resistance (IR, hyperandrogenemia, and chronic inflammation. It has also been shown that DNA mutations and alterations induced by OS are involved in cancer pathogenesis, tumor cell survival, proliferation, invasion, angiogenesis, and so on. Furthermore, recent studies show that the females with PCOS are reported to have an increasing risk of cancers. As a result, the more serious OS in PCOS is regarded as an important potential incentive for the increasing risk of cancers, and this study aims to analyze the possibility and potential pathogenic mechanism of the above process, providing insightful thoughts and evidences for preventing cancer potentially caused by PCOS in clinic.

Roles of Oxidative Stress in Polycystic Ovary Syndrome and Cancers

Science.gov (United States)

Zuo, Tao; Zhu, Minghui; Xu, Wenming

2016-01-01

Oxidative stress (OS) has received extensive attention in the last two decades, because of the discovery that abnormal oxidation status was related to patients with chronic diseases, such as diabetes, cardiovascular, polycystic ovary syndrome (PCOS), cancer, and neurological diseases. OS is considered as a potential inducing factor in the pathogenesis of PCOS, which is one of the most common complex endocrine disorders and a leading cause of female infertility, affecting 4%–12% of women in the world, as OS has close interactions with PCOS characteristics, just as insulin resistance (IR), hyperandrogenemia, and chronic inflammation. It has also been shown that DNA mutations and alterations induced by OS are involved in cancer pathogenesis, tumor cell survival, proliferation, invasion, angiogenesis, and so on. Furthermore, recent studies show that the females with PCOS are reported to have an increasing risk of cancers. As a result, the more serious OS in PCOS is regarded as an important potential incentive for the increasing risk of cancers, and this study aims to analyze the possibility and potential pathogenic mechanism of the above process, providing insightful thoughts and evidences for preventing cancer potentially caused by PCOS in clinic. PMID:26770659

THE INFLUENCE OF STRESS CONNECTED WITH PROFESSIONAL WORK ON THE OCCURRENCE OF BURNOUT SYNDROME IN NURSES WORKING IN SURGICAL AND MEDICAL TREATMENT WARDS

Directory of Open Access Journals (Sweden)

Grażyna Nowak-Starz

2013-11-01

Full Text Available Nursing is one of the professions where chronic stress is an inseparable characteristic and stems from the very nature of the profession itself. The job of a nurse involves particular mental burdens. The source of these is another person, one who has most often found themselves in an extreme situation. A nurse carries out her/his duties in a state of strong and long-lasting emotional strain. Inappropriate coping with stress and a lack of support from others in difficult situations leads to the development of burnout syndrome. This syndrome not only lowers, to a great extent, the quality of performed work but also prevents nurses from further professional development. Aims : The aim of the following paper is to evaluate the influence of stress connected with the professional work of a nurse on the occurrence of burnout syndrome. Material and methodology : Research was conducted on a group of 103 nurses working at eight hospital wards (surgical and medical treatment at the District Hospital in Lipsko. The research tool was a questionnaire of the author’s own devise, which contained 34 questions. Results : Among the examined nurses, 90% concluded that their professional work has a negative impact on their family life and they pointed to their own occupational burnout. Nurses who carried negative emotions over from work to their homes significantly more often showed a lack of satisfaction from their job and signs of occupational burnout. A substantial percentage of the participants considered shift-work and the professional position held to be a detrimental factor in the process of occupational burnout. Conclusion : The nurses were to a large extent exposed to mental burdens having a negative impact on their work. The vast majority of the respondents felt satisfaction from their job but a significant percentage of the respondents admitted to suffering from symptoms of chronic stress and exhaustion, which may indicate a lack of any support from co

Work Ability Index, Absenteeism and Depression Among Patients with Burnout Syndrome

OpenAIRE

Pranjic, Nurka; Males-Bilic, Ljiljana

2014-01-01

Goal: The aim of this study is to estimate the association of burnout syndrome and depression; burnout syndrome and sick leave; and burnout syndrome with Work Ability Index in patients who suffer from stress at work. Material and methods: The control clinical study was conducted in the Teaching Department for Professional Pathology and Toxicology at the Primary Health Care Center Tuzla in the period from 2009 to 2014. The study included 140 patients exposed to different levels of stress at wo...

75 FR 24434 - Federal Travel Regulation (FTR); Transportation in Conjunction With Official Travel and Relocation

Science.gov (United States)

2010-05-05

...-0010, sequence 1] RIN 3090-AJ02 Federal Travel Regulation (FTR); Transportation in Conjunction With Official Travel and Relocation AGENCY: Office of Governmentwide Policy, General Services Administration (GSA). ACTION: Final rule. SUMMARY: This final rule amends the Federal Travel Regulation (FTR), by...

Actual problems of management of territory and natural objects in the zone of population relocation at the Chernobyl' NPP

International Nuclear Information System (INIS)

Arkhipov, N.P.; Meshalkin, G.S.; Arkhipov, A.N.; Burov, N.I.; Mishenkov, N.N.; Fedotov, I.S.; Tursukova, T.A.; Kulikov, V.V.; Loginova, L.S.

1989-01-01

Basing on experimental data and using the research results and estimates of other authors an attempt is made to argue and formulate the principles of management for natural and agricultural lands, which can form the basis for development of the conception for use of the population relocation zone. The list of the first-priority works dealing with the problem of rational management of the zone natural objects is given. The necessity of development of the basis for organization of radioecologic nature, reserve, is shown. The scheme of organization of territory use in the population relocation zone is given. 2 figs.; 1 tab

Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?

Science.gov (United States)

O'Malley, Dervla; Quigley, Eamonn M M; Dinan, Timothy G; Cryan, John F

2011-10-01

Irritable bowel syndrome (IBS) is a common, debilitating gastrointestinal (GI) disorder, with a worldwide prevalence of between 10% and 20%. This functional gut disorder is characterized by episodic exacerbations of a cluster of symptoms including abdominal pain, bloating and altered bowel habit, including diarrhea and/or constipation. Risk factors for the development of IBS include a family history of the disorder, childhood trauma and prior gastrointestinal infection. It is generally accepted that brain-gut axis dysfunction is fundamental to the development of IBS; however the underlying pathophysiological mechanisms remain elusive. Additional considerations in comprehending the chronic relapsing pattern that typifies IBS symptoms are the effects of both psychosocial and infection-related stresses. Indeed, co-morbidity with mood disorders such as depression and anxiety is common in IBS. Accumulating evidence points to a role for a maladaptive stress response in the initiation, persistence and severity of IBS-associated symptom flare-ups. Moreover, mechanistically, the stress-induced secretion of corticotropin-releasing factor (CRF) is known to mediate changes in GI function. Activation of the immune system also appears to be important in the generation of IBS symptoms and increasing evidence now implicates low-grade inflammation or immune activation in IBS pathophysiology. There is a growing body of research focused on understanding at a molecular, cellular and in vivo level, the relationship between the dysregulated stress response and immune system alterations (either individually or in combination) in the etiology of IBS and to the occurrence of symptoms. Copyright © 2011 Elsevier Inc. All rights reserved.

Stres i wypalenie zawodowe w pracy ratowników medycznych = Stress and a burn-out syndrome at work among paramedics

Directory of Open Access Journals (Sweden)

Magdalena Żurowska-Wolak

2015-06-01

4.      Zakład Zdrowia Publicznego, Warszawski Uniwersytet Medyczny, Warszawa     Adres do korespondencji: Magdalena Żurowska-Wolak tel: 503 196 836;  e- mail: m_zurowska@vp.pl   Streszczenie: Zawód ratownika medycznego jest jednym zawodów, w których narażenie na stres jest wysokie oraz istnieje ryzyko wystąpienia zespołu wypalenia zawodowego. Celem badania było poznanie sposobów radzenia sobie ze stresem, stosowanych przez ratowników medycznych oraz występowania wśród nich objawów wypalenia zawodowego. Najczęstszym z nich było występowanie dużego zmęczenia po pracy. Większość badanych (64%  potwierdziła wykorzystywanie konstruktywnych sposobów radzenia sobie ze stresem, jak również niekonstruktywne stosowanie używek, w szczególności kofeiny i nikotyny, których spożycie wzrastało w sytuacjach trudnych. Na podstawie badań można wnioskować, że wśród ratowników medycznych, pracujących w Krakowie i okolicach, występuje niebezpiecznie dużo objawów wypalenia zawodowego. Świadczy to o potrzebie stworzenia i realizacji przez ich pracodawców działań, obniżających poziom stresu wśród pracowników oraz zapobiegających wystąpieniu wypalenia zawodowego – jak debriefing, trenieng technik radzenia sobie ze stresem czy wspierania aktywności fizycznej. Jest to o tyle istotne, iż skutki stresu oraz wypalenia odczuwają nie tylko sami ratownicy. Skutki te są dolegliwe także dla pracodawców, którzy zatrudniają gorzej funkcjonujących pracowników oraz pacjentów, otrzymujących usługi o niższej jakości.   Abstract: Paramedics are one of the professions where the risk of exposure to stress is high as well as the risk of occurrence of the burnout syndrome. The aim of the study was to analyze methods of stress reduction and symptoms of the burnout syndrome among 122 paramedics from Kraków and surrounding area. The most prevalent symptom was severe tiredness after working hours. The majority of respondents

76 FR 75450 - Safety Zone; Container Crane Relocation, Cooper and Wando Rivers, Charleston, SC

Science.gov (United States)

2011-12-02

...-AA00 Safety Zone; Container Crane Relocation, Cooper and Wando Rivers, Charleston, SC AGENCY: Coast... moving safety zone around a barge transporting two container cranes on the Cooper and Wando Rivers during... barge will transit the Cooper and Wando Rivers. Because of the size of the two container cranes and the...

Popliteal artery entrapment syndrome misdiagnosed as chronic ...

African Journals Online (AJOL)

A 21-year-old provincial rugby player complained of exercise- induced pain in both ... damage was present and after bilateral surgical release a few months apart he ... medial tibial stress syndrome, shin splints and stress fractures. Vascular ...

Earthquake effect on volcano and the geological structure in central java using tomography travel time method and relocation hypocenter by grid search method

International Nuclear Information System (INIS)

Suharsono; Nurdian, S. W; Palupi, I. R.

2016-01-01

Relocating hypocenter is a way to improve the velocity model of the subsurface. One of the method is Grid Search. To perform the distribution of the velocity in subsurface by tomography method, it is used the result of relocating hypocenter to be a reference for subsurface analysis in volcanic and major structural patterns, such as in Central Java. The main data of this study is the earthquake data recorded from 1952 to 2012 with the P wave number is 9162, the number of events is 2426 were recorded by 30 stations located in the vicinity of Central Java. Grid search method has some advantages they are: it can relocate the hypocenter more accurate because this method is dividing space lattice model into blocks, and each grid block can only be occupied by one point hypocenter. Tomography technique is done by travel time data that has had relocated with inversion pseudo bending method. Grid search relocated method show that the hypocenter's depth is shallower than before and the direction is to the south, the hypocenter distribution is modeled into the subduction zone between the continent of Eurasia with the Indo-Australian with an average angle of 14 °. The tomography results show the low velocity value is contained under volcanoes with value of -8% to -10%, then the pattern of the main fault structure in Central Java can be description by the results of tomography at high velocity that is from 8% to 10% with the direction is northwest and northeast-southwest. (paper)

Posttraumatic Stress Disorder in the DSM-5: Controversy, Change, and Conceptual Considerations

OpenAIRE

Pai, Anushka; Suris, Alina M.; North, Carol S.

2017-01-01

The criteria for posttraumatic stress disorder PTSD have changed considerably with the newest edition of the American Psychiatric Association’s (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Changes to the diagnostic criteria from the DSM-IV to DSM-5 include: the relocation of PTSD from the anxiety disorders category to a new diagnostic category named “Trauma and Stressor-related Disorders”, the elimination of the subjective component to the definition of trauma, the exp...

Cardiac damage associated with stress hyperglycaemia and acute coronary syndrome changes according to level of presenting blood glucose.

Science.gov (United States)

Al Jumaily, Talib; Rose'Meyer, Roselyn B; Sweeny, Amy; Jayasinghe, Rohan

2015-10-01

To determine the prevalence of stress hyperglycaemia in people presenting with acute coronary syndrome (ACS), and the relationships between admission glucose and cardiac damage, cardiovascular mortality and morbidity. In a prospective observational study people presenting with ACS at the Gold Coast Hospital had their admission glucose (AG) level tested to determine stress hyperglycaemia. A range of measurements supplemented this data including troponin levels, category of ACS and major adverse coronary events (MACEs) were obtained through hospital records and patient follow-up post-discharge. One hundred eighty-eight participants were recruited. The prevalence of stress hyperglycaemia in ACS was 44% with 31% having a previous diagnosis of type 2 diabetes and 7.7% had undiagnosed diabetes. The stress hyperglycaemic group had a significantly higher median troponin levels compared to participants with normal blood glucose levels on admission (pglucose group (>15 mmol/L) had troponin levels similar to people presenting with normal blood glucose levels and ACS (p>0.05). Cardiac necrosis as measured by troponin levels is significantly increased in people with ACS and stress hyperglycaemia. This study found that one in four participants presenting with ACS and an admission glucose of >7.0 had no previous diagnosis for diabetes. Consistently ordering HbA1C testing on patients with high AG can enable earlier diagnosis and treatment of diabetes. Copyright © 2015. Published by Elsevier Ireland Ltd.

Possible Link Between Stress-related Factors and Altered Body Composition in Women with Polycystic Ovarian Syndrome.

Science.gov (United States)

Basu, Barnali Ray; Chowdhury, Olivia; Saha, Sudip Kumar

2018-01-01

Stress is an invisible factor affecting modern day living and is strongly associated with many disease pathogenesis including polycystic ovarian syndrome (PCOS) in women. PCOS is the most frequent endocrinological disorder that affects women of reproductive age, leading to metabolic dysfunction and body composition alterations. Salivary amylase and cortisol are major stress mediators that have been implicated in PCOS. However, their role in altering body composition in PCOS is yet to be deciphered. The present study aimed at understanding the relation between stress-associated factors and alterations in body composition among PCOS patients. This study enrolled a total of 100 patients (PCOS) and 60 age-matched controls. The female patients were of ages between 13 and 30 years. Standard assay kits were used to evaluate the α-amylase activity and cortisol level in saliva. The participants were chosen on the basis of the Rotterdam American Society for Reproductive Medicine/European Society of Human Reproduction criteria. Saliva was collected from each participant as per the protocol of Salimetrics, USA. Statistical analysis was performed using SPSS version 20 for Windows. The quantitative variables are described as mean ± standard deviation. P stress scenario in their system. Moreover, overweight PCOS participants reflected higher amylase activity than the lean patients participants. Pulse rate, body mass index (BMI), visceral adiposity, and waist-hip ratio (WHR) was considerably higher in the PCOS patients participants compared to controls. A significant correlation could be drawn between the α-amylase activity and BMI or WHR, respectively, among PCOS patients. These observations indicate a strong link between the stress marker and alterations in the body composition parameters of PCOS patients participants. Higher prevalence of stress in PCOS patients participants has a critical role in their altered body composition.

Relocation of the 2010-2013 near the north coast of Papua earthquake sequence using Modified Joint Hypocenter Determination (MJHD) method

International Nuclear Information System (INIS)

Salomo, Dimas; Daryono,; Subakti, Hendri

2015-01-01

The accuracy of earthquake hypocenter position is necessary to analyze the tectonic conditions. This study aims to: (1) relocate the mainshock and aftershocks of the large earthquakes in Papua region i.e. June 16, 2010, April 21, 2012 and April 06, 2013 earthquake (2) determine the true fault plane, (3) estimate the area of the fracture, and (4) analyze the advantages and disadvantages of relocation with MJHD method in benefits for tectonic studies. This study used Modified Joint Hypocenter Determination (MJHD) method. Using P arrival phase data reported by the BMKG and openly available from website repogempa.bmkg.go.id, we relocated the mainshock of this large significant earthquake and its aftershocks. Then we identified the prefered fault planes from the candidate fault planes provided by the global CMT catalogue. The position of earthquakes was successfully relocated. The earthquakes mostly were clustered around the mainshock. Earthquakes that not clustered around mainshock are considered to be different mechanism from the mainshock. Relocation results indicate that the mainshock fault plane of June 16, 2010 earthquake is a field with strike 332o, dip 80o and −172o slip, the mainshock fault plane of April 21, 2012 earthquake is a field with strike 82o, dip 84o and 2o slip, the mainshock fault plane of April 06, 2013 earthquake is a field with strike 339o, dip 56o and −137o slip. Fault plane area estimated by cross section graphical method is an area of 2816.0 km2 (June 16, 2010), 906.2 km2 (April 21, 2012) and 1984.3 km2 (April 06, 2013). MJHD method has the advantage that it can calculate a lot of earthquakes simultaneously and has a station correction to account for lateral heterogeneity of the earth. This method successfully provides significant changes to improve the position of the depth of earthquakes that most of the hypocenter depth manually specified as a fixed depth (± 10 km). But this method cannot be sure that the hypocenters derived from the

Insulin resistance in non-obese women with polycystic ovary syndrome: relation to byproducts of oxidative stress.

Science.gov (United States)

Macut, D; Simic, T; Lissounov, A; Pljesa-Ercegovac, M; Bozic, I; Djukic, T; Bjekic-Macut, J; Matic, M; Petakov, M; Suvakov, S; Damjanovic, S; Savic-Radojevic, A

2011-07-01

To get more insight into molecular mechanisms underlying oxidative stress and its link with insulin resistance, oxidative stress parameters, as well as, antioxidant enzyme activities were studied in young, non-obese women with polycystic ovary syndrome (PCOS). Study was performed in 34 PCOS women and 23 age and body mass index (BMI)-matched healthy controls. Plasma nitrotyrosine and malondialdehyde (MDA), representative byproducts of protein and lipid oxidative damage, were determined by enzyme immunoassay. Antioxidant enzyme activities, superoxide dismutase (SOD) and glutathione peroxidase (GPX) were studied spectrophotometrically. Insulin resistance was calculated using homeostasis assessment model (HOMA-IR). Plasma nitrotyrosine and MDA were increased, but only nitrotyrosine was significantly higher (p PCOS women compared to controls. Uric acid (surrogate marker of × antine oxidase) was also significantly elevated in PCOS (p PCOS and controls. Indices of insulin resistance (insulin and HOMAIR) were significantly higher in PCOS group and positively correlated with level of MDA (r = 0.397 and r = 0.523, respectively; p insulin resistance could be responsible for the existence of subtle form of oxidative stress in young, nonobese PCOS women. Hence, presence of insulin resistance, hyperinsulinemia and oxidative damage are likely to accelerate slow development of cardiovascular disease in PCOS. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.

Relocating Precarity and Resiliency within Montreal: The Artists' Bloc of the Immigrant Workers' Centre

Science.gov (United States)

Hall, Koby Rogers; Salamanca, Manuel

2017-01-01

In this document we describe our experience relocating precarity and resiliency by way of arts activism, to denounce and make visible social injustices experienced by im/migrant communities in Montreal. Under the umbrella of the Immigrant Workers' Centre, and other allies from the im/migrant workers' movement, we combine knowledge building, action…

41 CFR 302-12.4 - For what relocation services expenses will my agency pay?

Science.gov (United States)

2010-07-01

... actual expenses the company incurs on your behalf, payment to the company is limited to what you would... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false For what relocation services expenses will my agency pay? 302-12.4 Section 302-12.4 Public Contracts and Property Management...

[Behaviour problems of children with Down syndrome in preschool-age - Results from the Heidelberg Down syndrome study].

Science.gov (United States)

Sarimski, Klaus

2018-05-01

We report on the frequency and the correlations of behaviour problems among children with Down syndrome in preschool-age. As part of a longitudinal study 48 mothers of children with Down syndrome completed the German version of the “Strengths and Difficulties Questionnaire” (SDQ-D) and the Parenting Stress Inventory (PSI). The mothers were asked to fill out the questionnaires when the children had a mean age of five years. The results were compared to norms from children with typical development. Thirty per cent of the children with Down syndrome were rated as abnormal. Specifically, mean scores indicating problems with children of the same age and hyperactivity were elevated. A regression analysis predicting the total problem score of the SDQ-D revealed maternal educational level, optimistic attitude, and subjective parental stress at the age of one year and the degree of behavioural abnormalities at the age of three years as significant influential factors. Early intervention for Down syndrome children should include supporting parenting competence and coping skills in order to prevent behaviour problems.

Relocation of Intermediate-depth Seismicity in the Relic Alboran Slab: Clustering and Relationship to Tearing and Dehydration Embrittlement.

Science.gov (United States)

Sun, M.; Bezada, M.

2017-12-01

Intermediate-depth seismicity outside active subduction zones is rare. However, there is a well-known occurrence of such events in a N-S elongated volume between Spain and Morocco, within what most researchers consider to be the relic Alboran slab. Partial subduction of, and tearing from the adjoining continental lithosphere have been suggested in this area. We investigate whether dehydration embrittlement or shear instability is more consistent with the Alboran intermediate depth seismicity by considering their location relative to the expected thermal structure and expected areas of high strain rate associated with thinning or tearing of the slab. We use a dense temporary seismograph deployment in Spain and Morocco to relocate 65 intermediate-depth events occurring between 2010 and 2013 in this region. The relocation procedure is realized by a grid-search approach that minimizes the normalized misfit between the picked times and travel times calculated using a regional 3D velocity model. Results indicate that, compared with catalog results, hypocenters after relocation are more concentrated in space; they tend to shift southward and eastward while no systematic shift in depth is observed. Relocated hypocenters concentrate at a depth range between 50-100 km and along a narrow longitude range around 4.5W. Investigation of the earthquake density distribution indicates these earthquakes concentrate into several clusters. One such cluster sits above the spain-arm of the Alboran slab and beneath the Spain continental lithosphere, indicating that it is likely associated to the thinning process of the Alboran slab. The other four clusters all lie within the interior of the slab. Interestingly, two of them are near the middle of the subducted lithosphere and the other two lie near its base. This observation seems at odds with expectations based on the two leading hypotheses for enabling brittle failure at intermediate depths.

A Model of Teacher Stress

Science.gov (United States)

Kyriacou, Chris; Sutcliffe, John

1978-01-01

A definition and model of teacher stress is presented which conceptualizes teacher stress as a response syndrome (anger or depression) mediated by (1) an appraisal of threat to the teacher's self-esteem or well-being and (2) coping mechanisms activated to reduce the perceived threat. (Author)

Impacting earthquake science and geoscience education: Educational programming to earthquake relocation

Science.gov (United States)

Carrick, Tina Louise

This dissertation is comprised of four studies: three related to research on geoscience education and another seismological study of the South Island of New Zealand. The geoscience education research is grounded in 10 years of data collection and its implications for best practices for recruitment and retention of underrepresented minority students into higher education in the geosciences. The seismological component contains results from the relocation of earthquakes from the 2009 Dusky Sound Mw 7.8 event, South Island, New Zealand. In recent years, many have cited a major concern that U.S. is not producing enough STEM graduates to fit the forecasted economic need. This situation is exacerbated by the fact that underrepresented minorities are becoming a growing portion of the population, and people in these groups enter STEM careers at rates much smaller than their proportion of the populations. Among the STEM disciplines the Geosciences are the worst at attracting young people from underrepresented minorities. This dissertation reports on results the Pathways program at the University of Texas at El Paso Pathways which sought to create a geoscience recruitment and training network in El Paso, Texas to increase the number of Hispanic Americans students to attain higher degrees and increase the awareness of the geosciences from 2002-2012. Two elements of the program were a summer program for high school students and an undergraduate research program conducted during the academic year, called PREP. Data collected from pre- and post-surveys from the summer program showed statistically significant positive changes in attitudes towards the geosciences. Longitudinal data shows a strong positive correlation of the program with retention of participants in the geoscience pipeline. Results from the undergraduate research program show that it produced far more women and minority geoscience professionals than national norms. Combination of the institutional data, focus

[Distribution and pollution assessment of heavy metals in soil of relocation areas from the Danjiangkou Reservoir].

Science.gov (United States)

Zhang, Lei; Qin, Yan-Wen; Zheng, Bing-Hui; Shi, Yao; Han, Chao-Nan

2013-01-01

The aim of this article is to explore the pollution level and potential ecological risk of heavy metals in soil of the relocation areas from the Danjiangkou Reservoir. The contents and spatial distribution of Cd, Pb, Cu, Zn, Cr and As in soil of the relocation areas from the Danjiangkou Reservoir were analyzed. The integrated pollution index and potential ecological risk index were used to evaluate the contamination degree and potential ecological risk of these elements. The results indicated that the average contents of Cd, Pb, Cu, Zn, Cr and As in the samples were 0.61, 23.11, 58.25, 22.65, 58.99 and 16.95 mg x kg(-1), respectively. Compared with the background value of soils from Henan province, all these 6 elements except Zn were enriched to some extent, especially Cd. Similar patterns were observed for the spatial distribution of Cu, Zn, and Pb. Compared with the contents of heavy metals in surface sediments of the typical domestic reservoirs, Cd and As in soil of the relocation areas from the Danjiangkou Reservoir were heavily accumulated. The correlation analysis showed that there were significant positive correlations among Pb, Cu, and Zn. And there was also significant positive correlation between Cr and Pb. In contrast, negative correlation was found between Cr and As. To sum up, the comprehensive assessment results showed that Cd was the primary element with high ecological risk.

Influence of Intimate Partner Violence on Domestic Relocation in Metropolitan and Non-Metropolitan Young Australian Women

NARCIS (Netherlands)

Dillon, Gina; Hussain, Rafat; Kibele, Eva; Rahman, Saifur; Loxton, Deborah

2016-01-01

Data from a national, population-based longitudinal study of Australian women (26-34 years) were analyzed to investigate the association between domestic relocation and multiple explanatory factors, namely intimate partner violence (IPV), metropolitan versus non-metropolitan residence, education,

Medial tibial stress syndrome: a critical review.

Science.gov (United States)

Moen, Maarten H; Tol, Johannes L; Weir, Adam; Steunebrink, Miriam; De Winter, Theodorus C

2009-01-01

Medial tibial stress syndrome (MTSS) is one of the most common leg injuries in athletes and soldiers. The incidence of MTSS is reported as being between 4% and 35% in military personnel and athletes. The name given to this condition refers to pain on the posteromedial tibial border during exercise, with pain on palpation of the tibia over a length of at least 5 cm. Histological studies fail to provide evidence that MTSS is caused by periostitis as a result of traction. It is caused by bony resorption that outpaces bone formation of the tibial cortex. Evidence for this overloaded adaptation of the cortex is found in several studies describing MTSS findings on bone scan, magnetic resonance imaging (MRI), high-resolution computed tomography (CT) scan and dual energy x-ray absorptiometry. The diagnosis is made based on physical examination, although only one study has been conducted on this subject. Additional imaging such as bone, CT and MRI scans has been well studied but is of limited value. The prevalence of abnormal findings in asymptomatic subjects means that results should be interpreted with caution. Excessive pronation of the foot while standing and female sex were found to be intrinsic risk factors in multiple prospective studies. Other intrinsic risk factors found in single prospective studies are higher body mass index, greater internal and external ranges of hip motion, and calf girth. Previous history of MTSS was shown to be an extrinsic risk factor. The treatment of MTSS has been examined in three randomized controlled studies. In these studies rest is equal to any intervention. The use of neoprene or semi-rigid orthotics may help prevent MTSS, as evidenced by two large prospective studies.

MECP2 Duplication Syndrome

DEFF Research Database (Denmark)

Signorini, Cinzia; De Felice, Claudio; Leoncini, Silvia

2016-01-01

Rett syndrome (RTT) and MECP2 duplication syndrome (MDS) are neurodevelopmental disorders caused by alterations in the methyl-CpG binding protein 2 (MECP2) gene expression. A relationship between MECP2 loss-of-function mutations and oxidative stress has been previously documented in RTT patients...... and murine models. To date, no data on oxidative stress have been reported for the MECP2 gain-of-function mutations in patients with MDS. In the present work, the pro-oxidant status and oxidative fatty acid damage in MDS was investigated (subjects n = 6) and compared to RTT (subjects n = 24) and healthy...... similar to those observed in RTT patients except for higher plasma F2-isoprostanes levels (P work shows unique data in patients affected by MDS. For the first...

Current status of investigations on molten fuel: Coolant interaction, material movement and relocation in LMFBRs in Russia

International Nuclear Information System (INIS)

Buksha, Yu.; Kuznetsov, I.

1994-01-01

The paper contains information on experimental studies and calculation codes, related to molten fuel-coolant interaction, material movement and relocation. Some calculation results for the BN-800 type reactor are presented. (author)

Stress experiences of family members of registered sex offenders.

Science.gov (United States)

Tewksbury, Richard; Levenson, Jill

2009-01-01

The collateral consequences of sex offender registration and notification (SORN) have been well established, although little evidence has supported the efficacy of SORN. Based on the belief that family members provide some of the most consistent, important, and intense forms of support for criminal offenders in general and registered sex offenders (RSOs) more specifically, the experiences of sanctions, losses, and stresses of these individuals is examined. Using survey responses from 584 individuals known to visit online support and advocacy groups for RSOs and their loved ones, this study identifies the stress levels and stressors experienced by this population. Findings show that family members of RSOs experience high levels of social isolation, fear, shame, property damage, and forced residential relocation. Perceived stress is significantly higher for those who are of lower economic means, feel isolated, have high levels of fear and shame/embarrassment, or were forced to move. (c) 2009 John Wiley & Sons, Ltd.

Age-Specific Determinants of Pulse Wave Velocity among Metabolic Syndrome Components, Inflammatory Markers, and Oxidative Stress.

Science.gov (United States)

Kim, Minkyung; Kim, Minjoo; Yoo, Hye Jin; Lee, Seung Yeon; Lee, Sang-Hyun; Lee, Jong Ho

2018-02-01

Pulse wave velocity (PWV) is thought to have different relationships with metabolic syndrome (MS) components, inflammatory markers, and oxidative stress, according to age. However, age-specific determinants of PWV have not yet been studied. We investigated age-dependent relationships among PWV and MS components, inflammatory markers, and oxidative stress. A total of 4,318 subjects were divided into 4 groups: 19-34 y (n=687), 35-44 y (n=1,413), 45-54 y (n=1,384), and 55-79 y (n=834). MS components, brachial-ankle PWV (baPWV), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress markers were measured. There were age-related increases in MS, body mass index (BMI), waist circumference, systolic blood pressure (SBP), diastolic BP (DBP), triglycerides, glucose, hs-CRP, oxidized low-density lipoprotein (LDL), 8-epi-prostaglandin F 2α (8-epi-PGF 2α ), and baPWV. BaPWV was significantly associated with sex and elevated BP in the 19-34 y group; with age, sex, BMI, elevated BP and triglycerides in the 35-44 y group; with age, sex, elevated BP, fasting glucose, hs-CRP and oxidized LDL in the 45-54 y group; and with age, BMI, elevated BP, fasting glucose and oxidized LDL in the 55-79 y group. Our results show that age-related increases in baPWV are associated with age-related changes in MS components, inflammatory markers, and oxidative stress. However, each of these factors has an age-specific, different impact on arterial stiffness. In particular, oxidative stress may be independently associated with arterial stiffness in individuals older than 45 y.

Fuel pellet relocation behavior in fast reactor uranium-plutonium mixed oxide fuel pin at beginning-of-life

International Nuclear Information System (INIS)

Inoue, Masaki; Ukai, Shigeharu; Asaga, Takeo

1999-08-01

The effects of fabrication parameters, irradiation conditions and fuel microstructural feature on fuel pellet relocation behavior in fast reactor fuel pins were investigated. This work focused only on beginning-of-life conditions, when fuel centerline temperature depends largely on the behavior. Fuel pellet relocation behavior in Joyo Mk-II driver could not be characterized because of the lack of data. And the behavior in FFTF driver and its larger diameter type fuel pins could not be characterized because of the extensive lot-by-lot scatters. The behavior both in Monju type and in Joyo power-to-melt type fuel pins were similar to each other, and depends largely on the as-fabricated gap width while the effects of linear heat rate and the extent of microstructural evolution were negligible. And fuel pellet centerline melting seems to affect slightly the behavior. The correlation, which describes the extent of relocation both in Monju type and in Joyo power-to-melt type fuel pins, were newly formulated and extrapolated for Joyo Mk-II driver, FFTF driver and its larger diameter type fuel pins. And the behavior in Joyo Mk-II driver seemed to be similar. On the contrary, the similarity with JNC fuel pins was observed case-by-case in FFTF driver and its larger diameter type fuel pins. (author)

Does social status within a dominance hierarchy mediate individual growth, residency and relocation?

Science.gov (United States)

Akbaripasand, Abbas; Ramezani, J; Krkosek, Martin; Lokman, P Mark; Closs, Gerard P

2014-11-01

The availability of food, and hence energy, is known to influence the abundance, habitat choice and growth of individuals. In contrast, there is a paucity of knowledge on how the interaction of energy supply and social status determines patterns of residency and movement. This study tests whether the presence of conspecifics and an individual's social status in relation to food supply influence the fitness and movement of a drift-feeding fish (Galaxias fasciatus). Using an information-theoretic approach (AIC), our analysis indicated that the most parsimonious model of fish movement among pools was one that included food supply, social rank and fish relative growth rate. Our results indicated that subordinate fish relocated more frequently compared to dominant fish, most likely as a consequence of intra-specific competition that limited the access of these smaller fish to resources and constrained their growth. Our results suggest that energy constraints may force individuals to explore new habitats in an effort to find more energetically profitable patches. We conclude that intra-specific competition mediated through the social hierarchy amongst closely interacting individuals plays a key role in determining individual growth, residency and relocation.

Selection of Models for Ingestion Pathway and Relocation

International Nuclear Information System (INIS)

Blanchard, A.; Thompson, J.M.

1998-01-01

The area in which intermediate phase protective actions (such as food interdiction and relocation) may be needed following postulated accidents at three Savannah River Site nonreactor nuclear facilities will be determined by modeling. The criteria used to select dispersion/deposition models are presented. Several models are considered, including ARAC, MACCS, HOTSPOT, WINDS (coupled with PUFF-PLUME), and UFOTRI. Although ARAC and WINDS are expected to provide more accurate modeling of atmospheric transport following an actual release, analyses consistent with regulatory guidance for planning purposes may be accomplished with comparatively simple dispersion models such as HOTSPOT and UFOTRI. A recommendation is made to use HOTSPOT for non-tritium facilities and UFOTRI for tritium facilities. The most recent Food and Drug Administration Derived Intervention Levels (August 1998) are adopted as evaluation guidelines for ingestion pathways

Selection of Models for Ingestion Pathway and Relocation

International Nuclear Information System (INIS)

Blanchard, A.; Thompson, J.M.

1999-01-01

The area in which intermediate phase protective actions (such as food interdiction and relocation) may be needed following postulated accidents at three Savannah River Site nonreactor nuclear facilities will be determined by modeling. The criteria used to select dispersion/deposition models are presented. Several models are considered, including ARAC, MACCS, HOTSPOT, WINDS (coupled with PUFF-PLUME), and UFOTRI. Although ARAC and WINDS are expected to provide more accurate modeling of atmospheric transport following an actual release, analyses consistent with regulatory guidance for planning purposes may be accomplished with comparatively simple dispersion models such as HOTSPOT and UFOTRI. A recommendation is made to use HOTSPOT for non-tritium facilities and UFOTRI for tritium facilities. The most recent Food and Drug Administration Derived Intervention Levels (August 1998) are adopted as evaluation guidelines for ingestion pathways

Investigation of the coolability of a continuous mass of relocated debris to a water-filled lower plenum. Technical report

International Nuclear Information System (INIS)

Rempe, J.L.; Wolf, J.R.; Chavez, S.A.; Condie, K.G.; Hagrman, D.L.; Carmack, W.J.

1994-09-01

This report documents work performed to support the development of an analytical and experimental program to investigate the coolability of a continuous mass of debris that relocates to a water-filled lower plenum. The objective of this program is to provide an adequate data base for developing and validating a model to predict the coolability of a continuous mass of debris relocating to a water-filled lower plenum. The model must address higher pressure scenarios, such as the TMI-2 accident, and lower pressure scenarios, which recent calculations indicate are more likely for most operating LWR plants. The model must also address a range of possible debris compositions

Work stress, premenstrual syndrome and dysphoric disorder: are there any associations?

Science.gov (United States)

Namavar Jahromi, B; Pakmehr, S; Hagh-Shenas, H

2011-03-01

Women with recurrent and severe symptoms are diagnosed as having premenstrual syndrome (PMS), and if they suffer from severe affective symptoms, a diagnosis of premenstrual dysphoric disorder (PMDD) is made. The purpose of this study was to determine the association of work stress with PMS and PMDD. Fifty-five female medical students in their internship program (ten 24-hour shifts per month) and 38 third-year female medical students without any shift duties were asked to participate in this study. A questionnaire was used to record demographic information and a self-report inventory was used to measure 13 symptoms relevant to PMS and PMDD according to DSM-IV criteria. All participants were asked to complete the inventory every night around midnight for those on shifts or before going to bed at home for 60 consecutive nights. Out of 55 volunteers in the shift-work group, 31 (56%) fulfilled the diagnostic criteria for PMS in contrast to 12 (32%) in the control group. The frequency of PMDD was 12 (22%) in the intern group and 5 (13%) in the control group. Twenty one students (55%) from the control group did not have PMS or PMDD, compared to 12 (22%) students from the shift workers. Decreased energy (70.9%) and irritability (65.4%) were the most frequent symptoms during the luteal phase in the shift-work group. Work stress and an increase in responsibility may produce or exacerbate PMS. Self-help approaches to induce self-awareness, along with psychological and psychiatric interventions, may help susceptible women to overcome this cyclic condition in order to increase their productivity as well as their quality of life.

Comparison of white spot syndrome virus infection resistance between Exopalaemon carinicauda and Litopenaeus vannamei under different salinity stresses

Science.gov (United States)

Ge, Qianqian; Yu, Ge; Sun, Ming; Li, Jitao; Li, Jian

2017-12-01

Exopalaemon carinicauda is one of the important economic shrimp species in China, and can tolerate a wide range of salinities. However, its disease resistance remains to be unclear in comparison with other shrimp species under salinity stress. In this study, the resistance to white spot syndrome virus (WSSV) of E. carinicauda and Litopenaeus vannamei was determined by comparing their hemocyanin (Hc) and phenoloxidase (PO) activities under different salinity stresses. In E. carinicauda, the PO activity and Hc gene transcript abundance showed a coherent pattern of increase and decrease while Hc content showed a slightly decrease with Vibrio anguillarum and WSSV infections. For both E. carinicauda and L. vannamei under salinity stress, the PO activity showed a positive correlation with the salinity while the Hc content and expression level of its gene increased significantly in salinities of 5, 15 and 25 g L-1. The survival rate of E. carinicauda with WSSV infection was higher than that of L. vannamei in the first 24 h under different salinity stresses. Drastic mortality of E.carinicauda and L. vannamei appeared at 48 h and 3 h post-injection, respectively. Furthermore, compared with L. vannamei, E. carinicauda displayed higher PO activity, Hc content and abundance of Hc gene mRNA. The results collectively indicated that Hc and PO have obviously functional connection in resisting pathogens and tolerating salinity stress, and PO activity and Hc gene mRNA abundance may reflect the resistance of shrimp to disease. E. carinicauda has higher level of immune potential than L. vannamei, suggesting its greater capacity in resisting pathogens under salinity stresses.

Association of abdominal obesity, insulin resistance, and oxidative stress in adipose tissue in women with polycystic ovary syndrome.

Science.gov (United States)

Chen, Li; Xu, Wen Ming; Zhang, Dan

2014-10-01

To study the expression of insulin signaling-related genes and oxidative stress markers in the visceral adipose tissue obtained from polycystic ovary syndrome (PCOS) patients and healthy control subjects and to investigate the relationships among abdominal obesity, insulin resistance, and oxidative stress at the tissue level. Case-control study. University teaching hospital. In total, 30 PCOS patients and 30 healthy control subjects, who underwent laparoscopic surgery, were included in the study. Abdominal obesity was defined based on waist circumference (WC). The homeostasis model index was used to assess insulin resistance (HOMA-IR). Gene expression of glucose transporter 4 (GLUT4) and insulin receptor substrate 1 (IRS1) in visceral adipose tissue (VAT) and the parameters of oxidative stress, such as superoxide dismutase, enzyme glutathione reductase, and dimethylarginine, were measured, and the expression of protein oxidative damage product 3-nitro-tyrosine residues (nitrotyrosine) in VAT was identified with the use of immunohistochemistry. PCOS was associated with lower expression of GLUT4 and IRS1 and a higher level of oxidative stress in VAT, which was strongly correlated with WC and HOMA-IR. Presence of abdominal obesity further intensified the correlations observed in our measurements. The nitrotyrosine expression in VAT was stronger in PCOS patients. The strong correlation of insulin resistance with oxidative stress at the VAT level suggests that local oxidative stress and abnormalities of insulin signaling in adipose tissue play critical roles in the pathogenesis of PCOS. Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress

DEFF Research Database (Denmark)

Kristensen, Hans-Ulrik Svejstrup; Epanchintsev, Alexey; Rauschendorf, Marc-Alexander

2013-01-01

Cockayne syndrome type B ATPase (CSB) belongs to the SwItch/Sucrose nonfermentable family. Its mutations are linked to Cockayne syndrome phenotypes and classically are thought to be caused by defects in transcription-coupled repair, a subtype of DNA repair. Here we show that after UV-C irradiation...

41 CFR 302-1.1 - Who is eligible for relocation expense allowances under this chapter?

Science.gov (United States)

2010-07-01

... Postal Service to an agency as defined in 5 U.S.C. 5721; (d) An employee performing travel in accordance... to the same or different Government agency. (f) A student trainee assigned to any position upon... Management Federal Travel Regulation System RELOCATION ALLOWANCES INTRODUCTION 1-GENERAL RULES Applicability...

Spontaneous Relocation of a Posterior Dislocation of Mobile Bearing in a Medial Unicompartmental Knee Replacement

Science.gov (United States)

Noureddine, Hussein; Aird, Jaimes; Latimer, Paul

2012-01-01

We describe a case of spontaneous relocation of a posterior dislocation of the mobile bearing in a medial unicompartmental knee replacement, prior to surgical intervention. We are unaware of any similar cases in the published literature. This paper highlights some clinical issues around this type of dislocation. PMID:23259116

SAFARI-1 research reactor beryllium reflector element replacement, management and relocation

International Nuclear Information System (INIS)

Kock, Marisa De; Vlok, Jwh; Steynberg, B.J.

2012-01-01

decommissioned beryllium elements were also measured to investigate the occurrence of ageing mechanisms and their consequences, and to determine the location of the element's vulnerable areas. This supports the Beryllium Management Programme in terms of an optimal shuffling scheme to mitigate the effects of ageing. Currently, the decommissioned beryllium reflector elements are stored in a storage rack within the reactor pool. Due to limited space it is necessary to relocate these elements. A proposed relocation strategy based on existing literature is discussed. This strategy covers the requirements, relocation process and types of storage to be considered. (author)

SAFARI-1 research reactor beryllium reflector element replacement, management and relocation

Energy Technology Data Exchange (ETDEWEB)

Kock, Marisa De; Vlok, Jwh; Steynberg, B J [South Africa Atomic Energy Corporation (Necsa) (South Africa)

2012-03-15

decommissioned beryllium elements were also measured to investigate the occurrence of ageing mechanisms and their consequences, and to determine the location of the element's vulnerable areas. This supports the Beryllium Management Programme in terms of an optimal shuffling scheme to mitigate the effects of ageing. Currently, the decommissioned beryllium reflector elements are stored in a storage rack within the reactor pool. Due to limited space it is necessary to relocate these elements. A proposed relocation strategy based on existing literature is discussed. This strategy covers the requirements, relocation process and types of storage to be considered. (author)

Compartment syndrome can also be seen in the forearm

DEFF Research Database (Denmark)

Asmar, Ali; Broholm, Rikke; Bülow, Jens

2014-01-01

Chronic compartment syndrome is a challenge for the clinician and symptomatic similar to neuropathies, tenosynovitis, stress fractures and referred pain from lumbar cervicalis. Thus, chronic compartment syndrome of the upper extremities is probably an underdiagnosed condition. In patients...

Neck and arm pain syndromes

DEFF Research Database (Denmark)

de las Peñas, César Fernández; Cleland, Joshua; Huijbregts, Peter

approaches.It uniquely addresses the expanding role of the various health care professions which require increased knowledge and skills in screening for contra-indications and recognizing the need for medical-surgical referral. Neck and Arm Pain Syndromes also stresses the integration of experiential......The first of its kind, Neck and Arm Pain Syndromes is a comprehensive evidence- and clinical-based book, covering research-based diagnosis, prognosis and management of neuromusculoskeletal pathologies and dysfunctions of the upper quadrant, including joint, muscle, myofascial and neural tissue...... of the most commonly seen pain syndromes in clinical practice over 800 illustrations demonstrating examination procedures and techniques....

[Child health environment in the context of relocating of camp site families to social housing].

Science.gov (United States)

Burgos, Soledad; Sigala, Fiorenza; Argueta, Luzmila; Iglesias, Verónica

2015-01-01

Housing interventions aimed at overcoming poverty can lead to changes in the health status of children by modifying risk factors in their physical and social environment the aim was to identify children's environmental health factors to change with the relocation of families from slums to public housing. A cross-sectional study was conducted in children ages 2-8 years old of families relocated to public housing (n=115) who were compared to children residing in slums (n=88) in Santiago, Chile. Family socioeconomic characteristics, indoor environment and neighborhoods were collected. It was included respiratory symptoms, accidents and maternal-child care of children. χ2, Fisher and Mann-Whitney test were used to compare groups. There were differences in households related to pets keeping, presence of humidity/molds in homes, types of fuels, and perceived safety problems in neighborhoods (p<0.05). The families from slums reported higher tenancy of pets (73.8% v/s 32.2%%), humidity/molds in homes (43.,2% v/s 18.3%), use of wood for heating (39.8% v/s 0.0%), compared with families of public housing. Residents of public housing perceived more safety problems in neighborhood, and children have more asthma related symptoms and have lower diversity of accidents in home. Among the factors studied, indoor air quality and safety in neighborhoods could be linked to changes from the relocation of families. This reinforces the need to deepen the positive and negative influences of residential mobility of these groups focused on child welfare perspective. Copyright © 2015 Sociedad Chilena de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

Duplication and relocation of the functional DPY19L2 gene within low copy repeats

Directory of Open Access Journals (Sweden)

Cheung Joseph

2006-03-01

Full Text Available Abstract Background Low copy repeats (LCRs are thought to play an important role in recent gene evolution, especially when they facilitate gene duplications. Duplicate genes are fundamental to adaptive evolution, providing substrates for the development of new or shared gene functions. Moreover, silencing of duplicate genes can have an indirect effect on adaptive evolution by causing genomic relocation of functional genes. These changes are theorized to have been a major factor in speciation. Results Here we present a novel example showing functional gene relocation within a LCR. We characterize the genomic structure and gene content of eight related LCRs on human Chromosomes 7 and 12. Two members of a novel transmembrane gene family, DPY19L, were identified in these regions, along with six transcribed pseudogenes. One of these genes, DPY19L2, is found on Chromosome 12 and is not syntenic with its mouse orthologue. Instead, the human locus syntenic to mouse Dpy19l2 contains a pseudogene, DPY19L2P1. This indicates that the ancestral copy of this gene has been silenced, while the descendant copy has remained active. Thus, the functional copy of this gene has been relocated to a new genomic locus. We then describe the expansion and evolution of the DPY19L gene family from a single gene found in invertebrate animals. Ancient duplications have led to multiple homologues in different lineages, with three in fish, frogs and birds and four in mammals. Conclusion Our results show that the DPY19L family has expanded throughout the vertebrate lineage and has undergone recent primate-specific evolution within LCRs.

The joint power of sex and stress to modulate brain-gut-microbiota axis and intestinal barrier homeostasis: implications for irritable bowel syndrome.

Science.gov (United States)

Pigrau, M; Rodiño-Janeiro, B K; Casado-Bedmar, M; Lobo, B; Vicario, M; Santos, J; Alonso-Cotoner, C

2016-04-01

Intestinal homeostasis is a dynamic process that takes place at the interface between the lumen and the mucosa of the gastrointestinal tract, where a constant scrutiny for antigens and toxins derived from food and microorganisms is carried out by the vast gut-associated immune system. Intestinal homeostasis is preserved by the ability of the mucus layer and the mucosal barrier to keep the passage of small-sized and antigenic molecules across the epithelium highly selective. When combined and preserved, immune surveillance and barrier's selective permeability, the host capacity of preventing the development of intestinal inflammation is optimized, and viceversa. In addition, the brain-gut-microbiome axis, a multidirectional communication system that integrates distant and local regulatory networks through neural, immunological, metabolic, and hormonal signaling pathways, also regulates intestinal function. Dysfunction of the brain-gut-microbiome axis may induce the loss of gut mucosal homeostasis, leading to uncontrolled permeation of toxins and immunogenic particles, increasing the risk of appearance of intestinal inflammation, mucosal damage, and gut disorders. Irritable bowel syndrome is prevalent stress-sensitive gastrointestinal disorder that shows a female predominance. Interestingly, the role of stress, sex and gonadal hormones in the regulation of intestinal mucosal and the brain-gut-microbiome axis functioning is being increasingly recognized. We aim to critically review the evidence linking sex, and stress to intestinal barrier and brain-gut-microbiome axis dysfunction and the implications for irritable bowel syndrome. © 2015 John Wiley & Sons Ltd.

Oxidative status and lipid profile in metabolic syndrome: gender differences.

Science.gov (United States)

Kaya, Aysem; Uzunhasan, Isil; Baskurt, Murat; Ozkan, Alev; Ataoglu, Esra; Okcun, Baris; Yigit, Zerrin

2010-02-01

Metabolic syndrome is associated with cardiovascular disease and oxidative stress. The aim of this study was to investigate the differences of novel oxidative stress parameters and lipid profiles in men and women with metabolic syndrome. The study population included 88 patients with metabolic syndrome, consisting of 48 postmenauposal women (group I) and 40 men (group II). Premenauposal women were excluded. Plasma levels of total antioxidant status (TAS) and total oxidative status (TOS) were determined by using the Erel automated measurement method, and oxidative stress index (OSI) was calculated. To perform the calculation, the resulting unit of TAS, mmol Trolox equivalent/L, was converted to micromol equivalent/L and the OSI value was calculated as: OSI = [(TOS, micromol/L)/(TAS, mmol Trolox equivalent/L) x 100]. The Student t-test, Mann-Whitney-U test, and chi-squared test were used for statistical analysis; the Pearson correlation coefficient and Spearman rank test were used for correlation analysis. P women and men had similar properties regarding demographic characteristics and biochemical work up. Group II had significantly lower levels of antioxidant levels of TAS and lower levels of TOS and OSI compared with group I (P = 0.0001, P = 0.0035, and P = 0,0001). Apolipoprotein A (ApoA) levels were significantly higher in group I compared with group II. Our findings indicate that women with metabolic syndrome have a better antioxidant status and higher ApoA levels compared with men. Our findings suggest the existence of a higher oxidative stress index in men with metabolic syndrome. Considering the higher risk of atherosclerosis associated with men, these novel oxidative stress parameters may be valuable in the evaluation of patients with metabolic sydrome.

Beneficial Effects of the RESMENA Dietary Pattern on Oxidative Stress in Patients Suffering from Metabolic Syndrome with Hyperglycemia Are Associated to Dietary TAC and Fruit Consumption

Directory of Open Access Journals (Sweden)

J. Alfredo Martinez

2013-03-01

Full Text Available Hyperglycemia and oxidative stress are conditions directly related to the metabolic syndrome (MetS, whose prevalence is increasing worldwide. This study aimed to evaluate the effectiveness of a new weight-loss dietary pattern on improving the oxidative stress status on patients suffering MetS with hyperglycemia. Seventy-nine volunteers were randomly assigned to two low-calorie diets (−30% Energy: the control diet based on the American Health Association criteria and the RESMENA diet based on a different macronutrient distribution (30% proteins, 30% lipids, 40% carbohydrates, which was characterized by an increase of the meal frequency (seven-times/day, low glycemic load, high antioxidant capacity (TAC and high n-3 fatty acids content. Dietary records, anthropometrical measurements, biochemical parameters and oxidative stress biomarkers were analyzed before and after the six-month-long study. The RESMENA (Metabolic Syndrome Reduction in Navarra diet specifically reduced the android fat mass and demonstrated more effectiveness on improving general oxidative stress through a greater decrease of oxidized LDL (oxLDL values and protection against arylesterase depletion. Interestingly, oxLDL values were associated with dietary TAC and fruit consumption and with changes on body mass index (BMI, waist circumference, fat mass and triacilglyceride (TG levels. In conclusion, the antioxidant properties of the RESMENA diet provide further benefits to those attributable to weight loss on patients suffering Mets with hyperglycemia.