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Sample records for relative normal vector

  1. On the Distribution of Norm of Vector Projection and Rejection of Two Complex Normal Random Vectors

    Directory of Open Access Journals (Sweden)

    Mehdi Maleki

    2015-01-01

    Full Text Available Vector projection and vector rejection are highly common and useful operations in mathematics, information theory, and signal processing. In this paper, we find the distribution of the norm of projection and rejection vectors when the original vectors are standard complex normally distributed.

  2. Application of Vectors to Relative Velocity

    Science.gov (United States)

    Tin-Lam, Toh

    2004-01-01

    The topic 'relative velocity' has recently been introduced into the Cambridge Ordinary Level Additional Mathematics syllabus under the application of Vectors. In this note, the results of relative velocity and the 'reduction to rest' technique of teaching relative velocity are derived mathematically from vector algebra, in the hope of providing…

  3. Generating Symbolic Interpolants for Scattered Data with Normal Vectors

    Institute of Scientific and Technical Information of China (English)

    Ming Li; Xiao-Shan Gao; Jin-San Cheng

    2005-01-01

    Algorithms to generate a triangular or a quadrilateral interpolant with G1-continuity are given in this paper for arbitrary scattered data with associated normal vectors over a prescribed triangular or quadrilateral decomposition.constraints. With the algorithm, we may obtain interpolants in complete symbolic parametric forms, leading to a fast computation of the interpolant. A dynamic interpolation solid modelling software package DISM is implemented based on the algorithm which can be used to generate and manipulate solid objects in an interactive way.

  4. Vector variational inequalities and their relations with vector optimization

    Directory of Open Access Journals (Sweden)

    Surjeet Kaur Suneja

    2014-01-01

    Full Text Available In this paper, K- quasiconvex, K- pseudoconvex and other related functions have been introduced in terms of their Clarke subdifferentials, where is an arbitrary closed convex, pointed cone with nonempty interior. The (strict, weakly -pseudomonotonicity, (strict K- naturally quasimonotonicity and K- quasimonotonicity of Clarke subdifferential maps have also been defined. Further, we introduce Minty weak (MVVIP and Stampacchia weak (SVVIP vector variational inequalities over arbitrary cones. Under regularity assumption, we have proved that a weak minimum solution of vector optimization problem (VOP is a solution of (SVVIP and under the condition of K- pseudoconvexity we have obtained the converse for MVVIP (SVVIP. In the end we study the interrelations between these with the help of strict K-naturally quasimonotonicity of Clarke subdifferential map.

  5. Period function and normalizers of vector fields in R with n-1 first integrals

    Science.gov (United States)

    Peralta-Salas, D.

    We extend the theory that relates period function, normalizers and first integrals, which has been widely developed in R, to any dimension. In particular, we show how to find n-1 independent normalizers of vector fields in R with n-1 independent first integrals. A formula for the derivatives of the period function is obtained and a necessary and sufficient condition for isochronicity is also proved. These results generalize previous works of Freire, Gasull and Guillamon, Sabatini and Villarini.

  6. Super Normal Vector for Human Activity Recognition with Depth Cameras.

    Science.gov (United States)

    Yang, Xiaodong; Tian, YingLi

    2017-05-01

    The advent of cost-effectiveness and easy-operation depth cameras has facilitated a variety of visual recognition tasks including human activity recognition. This paper presents a novel framework for recognizing human activities from video sequences captured by depth cameras. We extend the surface normal to polynormal by assembling local neighboring hypersurface normals from a depth sequence to jointly characterize local motion and shape information. We then propose a general scheme of super normal vector (SNV) to aggregate the low-level polynormals into a discriminative representation, which can be viewed as a simplified version of the Fisher kernel representation. In order to globally capture the spatial layout and temporal order, an adaptive spatio-temporal pyramid is introduced to subdivide a depth video into a set of space-time cells. In the extensive experiments, the proposed approach achieves superior performance to the state-of-the-art methods on the four public benchmark datasets, i.e., MSRAction3D, MSRDailyActivity3D, MSRGesture3D, and MSRActionPairs3D.

  7. Approximate Nearest Neighbor Search for a Dataset of Normalized Vectors

    Science.gov (United States)

    Terasawa, Kengo; Tanaka, Yuzuru

    This paper describes a novel algorithm for approximate nearest neighbor searching. For solving this problem especially in high dimensional spaces, one of the best-known algorithm is Locality-Sensitive Hashing (LSH). This paper presents a variant of the LSH algorithm that outperforms previously proposed methods when the dataset consists of vectors normalized to unit length, which is often the case in pattern recognition. The LSH scheme is based on a family of hash functions that preserves the locality of points. This paper points out that for our special case problem we can design efficient hash functions that map a point on the hypersphere into the closest vertex of the randomly rotated regular polytope. The computational analysis confirmed that the proposed method could improve the exponent ρ, the main indicator of the performance of the LSH algorithm. The practical experiments also supported the efficiency of our algorithm both in time and in space.

  8. Vector Potential Generation for Numerical Relativity Simulations

    Science.gov (United States)

    Silberman, Zachary; Faber, Joshua; Adams, Thomas; Etienne, Zachariah; Ruchlin, Ian

    2017-01-01

    Many different numerical codes are employed in studies of highly relativistic magnetized accretion flows around black holes. Based on the formalisms each uses, some codes evolve the magnetic field vector B, while others evolve the magnetic vector potential A, the two being related by the curl: B=curl(A). Here, we discuss how to generate vector potentials corresponding to specified magnetic fields on staggered grids, a surprisingly difficult task on finite cubic domains. The code we have developed solves this problem in two ways: a brute-force method, whose scaling is nearly linear in the number of grid cells, and a direct linear algebra approach. We discuss the success both algorithms have in generating smooth vector potential configurations and how both may be extended to more complicated cases involving multiple mesh-refinement levels. NSF ACI-1550436

  9. Precise on-machine extraction of the surface normal vector using an eddy current sensor array

    Science.gov (United States)

    Wang, Yongqing; Lian, Meng; Liu, Haibo; Ying, Yangwei; Sheng, Xianjun

    2016-11-01

    To satisfy the requirements of on-machine measurement of the surface normal during complex surface manufacturing, a highly robust normal vector extraction method using an Eddy current (EC) displacement sensor array is developed, the output of which is almost unaffected by surface brightness, machining coolant and environmental noise. A precise normal vector extraction model based on a triangular-distributed EC sensor array is first established. Calibration of the effects of object surface inclination and coupling interference on measurement results, and the relative position of EC sensors, is involved. A novel apparatus employing three EC sensors and a force transducer was designed, which can be easily integrated into the computer numerical control (CNC) machine tool spindle and/or robot terminal execution. Finally, to test the validity and practicability of the proposed method, typical experiments were conducted with specified testing pieces using the developed approach and system, such as an inclined plane and cylindrical and spherical surfaces.

  10. Structural Vector Description and Estimation of Normal Boiling Points for 66 Aromatic Hydrocarbons

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A molecular vector-type descriptor containing 6 variables is used to describe the structure of aromatic hydrocarbons (AHs) and relate to normal boiling points (bp) of AHs. The correlation coefficient (R) between the estimated bp and experimental bp is 0.9988 and the root mean square error (RMS) is 7.907° C for 66 AHs. The RMS obtained by cross-validation is 9.131° C, which implies the relationship model having good prediction ability.

  11. Fast normal random number generators on vector processors

    OpenAIRE

    Brent, Richard P.

    2010-01-01

    We consider pseudo-random number generators suitable for vector processors. In particular, we describe vectorised implementations of the Box-Muller and Polar methods, and show that they give good performance on the Fujitsu VP2200. We also consider some other popular methods, e.g. the Ratio method of Kinderman and Monahan (1977) (as improved by Leva (1992)), and the method of Von Neumann and Forsythe, and show why they are unlikely to be competitive with the Polar method on vector processors.

  12. Transverse Ward-Takahashi Relation for the Vector Vertex in Quantum Field Theory

    Institute of Scientific and Technical Information of China (English)

    HE Han-Xin

    2001-01-01

    The transverse Ward-Takahashi (W-T) relation for the vector vertex in quantum field theory is derived by calculating the curl of the time-ordered product of the three-point function including the vector current operator. This provides the constraint on the transverse part of the vertex. By combining the transverse and normal (longitudinal)W-T identities, we obtain the expression for the full vector vertex function.``

  13. [Normal values of bioimpedance vector in Spanish population].

    Science.gov (United States)

    Atilano-Carsi, Ximena; Bajo, María Auxiliadora; Del Peso, Gloria; Sánchez, Rafael; Selgas, Rafael

    2014-10-03

    Fundamento y objetivo: El análisis de vectores de impedancia es útil para la determinación de la composición corporal en pacientes con alteración del estado de hidratación. Las elipses de tolerancia originales fueron hechas en individuos sanos italianos. Debido a las diferencias en composición corporal entre poblaciones, el objetivo del estudio fue establecer elipses de tolerancia específicas para la población española y compararlas con las elipses realizadas en la población original de referencia. Material y método: Se estudiaron 311 sujetos sanos españoles de ambos sexos, entre 18 y 80 años, con IMC entre 18 y 31 Kg/m2, a los cuales se les realizaron mediciones de peso, estatura e impedancia bioeléctrica. Los valores de resistencia y reactancia estandarizadas por la estatura (R/E y Xc/E) derivados de la medición de impedancia, fueron utilizados para determinar la composición corporal y realizar las elipses de referencias específicas para dicha población. Resultados: Las características de composición corporal fueron diferentes entre sexos y grupo etario. Se graficaron los valores de R/E y Xc/E de la población española sobre las elipses de tolerancia italianas, encontrándose que los vectores se situaban en los cuadrantes izquierdos, indicando diferente composición corporal, por lo que se construyeron elipses de tolerancia específicas para la población española a partir de los valores de R/E y Xc/E. Las elipses de tolerancia españolas fueron estadísticamente diferentes a las italianas. Conclusiones: Los vectores de la población española fueron diferentes a los de la población italiana, de ahí la importancia de tener un patrón de referencia propio.

  14. Estimating differential quantities from point cloud based on a linear fitting of normal vectors

    Institute of Scientific and Technical Information of China (English)

    CHENG ZhangLin; ZHANG XiaoPeng

    2009-01-01

    Estimation of differential geometric properties on a discrete surface Is a fundamental work in computer graphics and computer vision.In this paper,we present an accurate and robust method for estimating differential quantities from unorganized point cloud.The principal curvatures and principal directions at each point are computed with the help of partial derivatives of the unit normal vector at that point,where the normal derivatives are estimated by fitting a linear function to each component of the normal vectors in a neighborhood.This method takes into account the normal information of all neighboring points and computes curvatures directly from the varlation of unit normal vectors,which improves the accuracy and robustness of curvature estimation on irregular sampled noisy data.The main advantage of our approach is that the estimation of curvatures at a point does not rely on the accuracy of the normal vector at that point,and the normal vectors can he refined In the process of curvature estimation.Compared with the state of the art methods for estimating curvatures and Darboux frames on both synthetic and real point clouds,the approach is shown to be more accurate and robust for noisy and unorganized point cloud data.

  15. Vector model for normal and dichromatic color vision.

    Science.gov (United States)

    Guth, S L; Massof, R W; Benzschawel, T

    1980-02-01

    The inclusion of cone mechanisms in a slightly revised version of an earlier model allows accounts of phenomena that involve receptor effects as well as dichromatic color vision. Intensity-dependent parameters that stimulate the adaptation of receptors and opponent and nonopponent mechanisms are varied to predict a wide range of data for both normals and dichromats, including: (i) color matching; (ii) the approximate apparent hue and saturation of the spectrum; (iii) foveal spectral sensitivities obtained by flicker photometry and by detection in the dark and under conditions of achromatic or chromatic adaptation; (iv) heterochromatic additivity failures in the dark-adapted and chromatically adapted eye; (v) approximate differences between brightness and luminance; and, (vi) color and wavelength discrimination under varying adaptation conditions.

  16. The vector projection of normalized interferogram differences and its application in phase-shift estimation

    Science.gov (United States)

    Li, Teng; Hong, Daxiang

    2016-04-01

    From three interferograms, a novel algorithm for extracting phase shifts based on the vector projection of normalized difference maps is presented. In it, subtraction and vector normalization are operated successively to obtain two normalized interferogram differences without the effect of background component. Then, the phase shift can be estimated based on the analysis and calculation of the vector projection. Without any iteration and complex calculation, this algorithm can be implemented for phase-shift range approximately being well distributed from 0 to 2π, when fringe number of interferograms is more than one. It offers a powerful tool for rapid calibration of phase shifts because of its high efficiency and easy implementation. Numerical simulations and experiments are performed to prove its validity.

  17. Normal families related to shared sets

    Institute of Scientific and Technical Information of China (English)

    LV Feng-jiao; LI Jiang-tao

    2008-01-01

    We studied the normality criterion for families of meromorphic functions related to shared sets. Let F be a family of meromorphic functions on the unit disc (, a and b be distinct non-zero values, S={a,b}, and k be a positive integer. If for every f∈F, i) the zeros of f(z) have a multiplicity of at least k+1, and ii) , then F is normal on (. At the same time, the corresponding results of normal function are also proved.

  18. REGULAR RELATIONS AND MONOTONE NORMAL ORDERED SPACES

    Institute of Scientific and Technical Information of China (English)

    XU XIAOQUAN; LIU YINGMING

    2004-01-01

    In this paper the classical theorem of Zareckii about regular relations is generalized and an intrinsic characterization of regularity is obtained. Based on the generalized Zareckii theorem and the intrinsic characterization of regularity, the authors give a characterization of monotone normality of ordered spaces. A new proof of the UrysohnNachbin lemma is presented which is quite different from the classical one.

  19. Reflection and transmission of full-vector X-waves normally incident on dielectric half spaces

    KAUST Repository

    Salem, Mohamed

    2011-08-01

    The reflection and transmission of full-vector X-Waves incident normally on a planar interface between two lossless dielectric half-spaces are investigated. Full-vector X-Waves are obtained by superimposing transverse electric and magnetic polarization components, which are derived from the scalar X-Wave solution. The analysis of transmission and reflection is carried out via a straightforward but yet effective method: First, the X-Wave is decomposed into vector Bessel beams via the Bessel-Fourier transform. Then, the reflection and transmission coefficients of the beams are obtained in the spectral domain. Finally, the transmitted and reflected X-Waves are obtained via the inverse Bessel-Fourier transform carried out on the X-wave spectrum weighted with the corresponding coefficient. © 2011 IEEE.

  20. Reflection and transmission of normally incident full-vector X waves on planar interfaces

    KAUST Repository

    Salem, Mohamed

    2011-12-23

    The reflection and transmission of full-vector X waves normally incident on planar half-spaces and slabs are studied. For this purpose, X waves are expanded in terms of weighted vector Bessel beams; this new decomposition and reconstruction method offers a more lucid and intuitive interpretation of the physical phenomena observed upon the reflection or transmission of X waves when compared to the conventional plane-wave decomposition technique. Using the Bessel beam expansion approach, we have characterized changes in the field shape and the intensity distribution of the transmitted and reflected full-vector X waves. We have also identified a novel longitudinal shift, which is observed when a full-vector X wave is transmitted through a dielectric slab under frustrated total reflection condition. The results of our studies presented here are valuable in understanding the behavior of full-vector X waves when they are utilized in practical applications in electromagnetics, optics, and photonics, such as trap and tweezer setups, optical lithography, and immaterial probing. © 2011 Optical Society of America.

  1. Vectores

    OpenAIRE

    2016-01-01

    Documento que contiene la explicación sobre las temáticas de Sistemas coordenados, Cantidades vectoriales y escalares, Algunas propiedades de los vectores, Componentes de un vector y vectores unitarios

  2. Normal Vector Projection Method used for Convex Optimization of Chan-Vese Model for Image Segmentation

    Science.gov (United States)

    Wei, W. B.; Tan, L.; Jia, M. Q.; Pan, Z. K.

    2017-01-01

    The variational level set method is one of the main methods of image segmentation. Due to signed distance functions as level sets have to keep the nature of the functions through numerical remedy or additional technology in an evolutionary process, it is not very efficient. In this paper, a normal vector projection method for image segmentation using Chan-Vese model is proposed. An equivalent formulation of Chan-Vese model is used by taking advantage of property of binary level set functions and combining with the concept of convex relaxation. Threshold method and projection formula are applied in the implementation. It can avoid the above problems and obtain a global optimal solution. Experimental results on both synthetic and real images validate the effects of the proposed normal vector projection method, and show advantages over traditional algorithms in terms of computational efficiency.

  3. Local normal vector field formulation for periodic scattering problems formulated in the spectral domain.

    Science.gov (United States)

    van Beurden, M C; Setija, I D

    2017-02-01

    We present two adapted formulations, one tailored to isotropic media and one for general anisotropic media, of the normal vector field framework previously introduced to improve convergence near arbitrarily shaped material interfaces in spectral simulation methods for periodic scattering geometries. The adapted formulations enable the definition and generation of the normal vector fields to be confined to a region of prolongation that includes the material interfaces but is otherwise limited. This allows for a more flexible application of geometrical transformations like rotation and translation per scattering object in the unit cell. Moreover, these geometrical transformations enable a cut-and-connect strategy to compose general geometries from elementary building blocks. The entire framework gives rise to continuously parameterized geometries.

  4. Relative K-homology and normal operators

    DEFF Research Database (Denmark)

    Manuilov, Vladimir; Thomsen, Klaus

    2009-01-01

    Let $A$ be a $C^*$-algebra, $J \\subset A$ a $C^*$-subalgebra, and let $B$ be a stable $C^*$-algebra. Under modest assumptions we organize invertible $C^*$-extensions of $A$ by $B$ that are trivial when restricted onto $J$ to become a group $\\mathrm{Ext}_J^{-1}(A,B)$, which can be computed by a six......-term exact sequence which generalizes the excision six-term exact sequence in the first variable of KK-theory. Subsequently we investigate the relative K-homology which arises from the group of relative extensions by specializing to abelian $C^*$-algebras. It turns out that this relative K-homology carries...... substantial information also in the operator theoretic setting from which the BDF theory was developed and we conclude the paper by extracting some of this information on approximation of normal operators....

  5. Error Vector Normalized Adaptive Algorithm Applied to Adaptive Noise Canceller and System Identification

    Directory of Open Access Journals (Sweden)

    Zayed Ramadan

    2010-01-01

    Full Text Available Problem statement: This study introduced a variable step-size Least Mean-Square (LMS algorithm in which the step-size is dependent on the Euclidian vector norm of the system output error. The error vector includes the last L values of the error, where L is a parameter to be chosen properly together with other parameters in the proposed algorithm to achieve a trade-off between speed of convergence and misadjustment. Approach: The performance of the algorithm was analyzed, simulated and compared to the Normalized LMS (NLMS algorithm in several input environments. Results: Computer simulation results demonstrated substantial improvements in the speed of convergence of the proposed algorithms over other algorithms in stationary environments for the same small level of misadjustment. In addition, the proposed algorithm shows superior tracking capability when the system is subjected to an abrupt disturbance. Conclusion: For nonstationary environments, the algorithm performs as well NLMS and other variable step-size algorithms.

  6. Mechanical remodeling of normally sized mammalian cells under a gravity vector.

    Science.gov (United States)

    Zhang, Chen; Zhou, Lüwen; Zhang, Fan; Lü, Dongyuan; Li, Ning; Zheng, Lu; Xu, Yanhong; Li, Zhan; Sun, Shujin; Long, Mian

    2017-02-01

    Translocation of the dense nucleus along a gravity vector initiates mechanical remodeling of a cell, but the underlying mechanisms of cytoskeletal network and focal adhesion complex (FAC) reorganization in a mammalian cell remain unclear. We quantified the remodeling of an MC3T3-E1 cell placed in upward-, downward-, or edge-on-orientated substrate. Nucleus longitudinal translocation presents a high value in downward orientation at 24 h or in edge-on orientation at 72 h, which is consistent with orientation-dependent distribution of perinuclear actin stress fibers and vimentin cords. Redistribution of total FAC area and fractionized super mature adhesion number coordinates this dependence at short duration. This orientation-dependent remodeling is associated with nucleus flattering and lamin A/C phosphorylation. Actin depolymerization or Rho-associated protein kinase signaling inhibition abolishes the orientation dependence of nucleus translocation, whereas tubulin polymerization inhibition or vimentin disruption reserves the dependence. A biomechanical model is therefore proposed for integrating the mechanosensing of nucleus translocation with cytoskeletal remodeling and FAC reorganization induced by a gravity vector.-Zhang, C., Zhou, L., Zhang, F., Lü, D., Li, N., Zheng, L., Xu, Y., Li, Z., Sun, S., Long, M. Mechanical remodeling of normally sized mammalian cells under a gravity vector. © FASEB.

  7. Vectors

    DEFF Research Database (Denmark)

    Boeriis, Morten; van Leeuwen, Theo

    2017-01-01

    This article revisits the concept of vectors, which, in Kress and van Leeuwen’s Reading Images (2006), plays a crucial role in distinguishing between ‘narrative’, action-oriented processes and ‘conceptual’, state-oriented processes. The use of this concept in image analysis has usually focused...... on the most salient vectors, and this works well, but many images contain a plethora of vectors, which makes their structure quite different from the linguistic transitivity structures with which Kress and van Leeuwen have compared ‘narrative’ images. It can also be asked whether facial expression vectors...... should be taken into account in discussing ‘reactions’, which Kress and van Leeuwen link only to eyeline vectors. Finally, the question can be raised as to whether actions are always realized by vectors. Drawing on a re-reading of Rudolf Arnheim’s account of vectors, these issues are outlined...

  8. Estimation Normal Vector of Triangular Mesh Vertex by Angle and Centroid Weights and its Application

    Directory of Open Access Journals (Sweden)

    Yueping Chen

    2013-04-01

    Full Text Available To compute vertex normal of triangular meshes more accurately, this paper presents an improved algorithm based on angle and centroid weights. Firstly, four representational algorithms are analyzed by comparing their weighting characteristics such as angles, areas and centroids. The drawbacks of each algorithm are discussed. Following that, an improved algorithm is put forward based on angle and centroid weights. Finally, by taking the deviation angle between the nominal normal vector and the estimated one as the error evaluation standard factor, the triangular mesh models of spheres, ellipsoids, paraboloids and cylinders are used to analyze the performance of all these estimation algorithms. The machining and inspection operations of one mould part are conducted to verify the improved algorithm. Experimental results demonstrate that the algorithm is effective.

  9. Relative Radiometric Normalization of Multitemporal images

    Directory of Open Access Journals (Sweden)

    Andrés Castillo Sanz

    2010-12-01

    Full Text Available A correct radiometric normalization between both images is fundamental for change detection. MAD method and its IR-MAD extension in an implementation on multisprectral aerial images is described in this paper

  10. A vector relational data modeling approach to Insider threat intelligence

    Science.gov (United States)

    Kelly, Ryan F.; Anderson, Thomas S.

    2016-05-01

    We address the problem of detecting insider threats before they can do harm. In many cases, co-workers notice indications of suspicious activity prior to insider threat attacks. A partial solution to this problem requires an understanding of how information can better traverse the communication network between human intelligence and insider threat analysts. Our approach employs modern mobile communications technology and scale free network architecture to reduce the network distance between human sensors and analysts. In order to solve this problem, we propose a Vector Relational Data Modeling approach to integrate human "sensors," geo-location, and existing visual analytics tools. This integration problem is known to be difficult due to quadratic increases in cost associated with complex integration solutions. A scale free network integration approach using vector relational data modeling is proposed as a method for reducing network distance without increasing cost.

  11. Identification of Conversion from Normal Elderly Cognition to Alzheimer's Disease using Multimodal Support Vector Machine.

    Science.gov (United States)

    Zhan, Ye; Chen, Kewei; Wu, Xia; Zhang, Daoqiang; Zhang, Jiacai; Yao, Li; Guo, Xiaojuan

    2015-01-01

    Alzheimer's disease (AD) is one of the most serious progressive neurodegenerative diseases among the elderly, therefore the identification of conversion to AD at the earlier stage has become a crucial issue. In this study, we applied multimodal support vector machine to identify the conversion from normal elderly cognition to mild cognitive impairment (MCI) or AD based on magnetic resonance imaging and positron emission tomography data. The participants included two independent cohorts (Training set: 121 AD patients and 120 normal controls (NC); Testing set: 20 NC converters and 20 NC non-converters) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. The multimodal results showed that the accuracy, sensitivity, and specificity of the classification between NC converters and NC non-converters were 67.5% , 73.33% , and 64% , respectively. Furthermore, the classification results with feature selection increased to 70% accuracy, 75% sensitivity, and 66.67% specificity. The classification results using multimodal data are markedly superior to that using a single modality when we identified the conversion from NC to MCI or AD. The model built in this study of identifying the risk of normal elderly converting to MCI or AD will be helpful in clinical diagnosis and pathological research.

  12. A robust method for calculating interface curvature and normal vectors using an extracted local level set

    CERN Document Server

    Ervik, Åsmund; Munkejord, Svend Tollak

    2014-01-01

    The level-set method is a popular interface tracking method in two-phase flow simulations. An often-cited reason for using it is that the method naturally handles topological changes in the interface, e.g. merging drops, due to the implicit formulation. It is also said that the interface curvature and normal vectors are easily calculated. This last point is not, however, the case in the moments during a topological change, as several authors have already pointed out. Various methods have been employed to circumvent the problem. In this paper, we present a new such method which retains the implicit level-set representation of the surface and handles general interface configurations. It is demonstrated that the method extends easily to 3D. The method is validated on static interface configurations, and then applied to two-phase flow simulations where the method outperforms the standard method and the results agree well with experiments.

  13. Normal vector method for convergence improvement using the RCWA for crossed gratings.

    Science.gov (United States)

    Schuster, Thomas; Ruoff, Johannes; Kerwien, Norbert; Rafler, Stephan; Osten, Wolfgang

    2007-09-01

    The rigorous coupled wave analysis (RCWA) is a widely used method for simulating diffraction from periodic structures. Since its recognized formulation by Moharam [J. Opt. Soc. Am. A12, 1068 and 1077 (1995)], there still has been a discussion about convergence problems. Those problems are more or less solved for the diffraction from line gratings, but there remain different concurrent proposals about the convergence improvement for crossed gratings. We propose to combine Popov and Nevière's formulation of the differential method [Light Propagation in Periodic Media (Dekker, 2003) and J. Opt. Soc. Am. A18, 2886 (2001)] with the classical RCWA. With a suitable choice of a normal vector field we obtain a better convergence than for the formulations that are known from the literature.

  14. Estimating normal mixture parameters from the distribution of a reduced feature vector

    Science.gov (United States)

    Guseman, L. F.; Peters, B. C., Jr.; Swasdee, M.

    1976-01-01

    A FORTRAN computer program was written and tested. The measurements consisted of 1000 randomly chosen vectors representing 1, 2, 3, 7, and 10 subclasses in equal portions. In the first experiment, the vectors are computed from the input means and covariances. In the second experiment, the vectors are 16 channel measurements. The starting covariances were constructed as if there were no correlation between separate passes. The biases obtained from each run are listed.

  15. Control-group feature normalization for multivariate pattern analysis of structural MRI data using the support vector machine.

    Science.gov (United States)

    Linn, Kristin A; Gaonkar, Bilwaj; Satterthwaite, Theodore D; Doshi, Jimit; Davatzikos, Christos; Shinohara, Russell T

    2016-05-15

    Normalization of feature vector values is a common practice in machine learning. Generally, each feature value is standardized to the unit hypercube or by normalizing to zero mean and unit variance. Classification decisions based on support vector machines (SVMs) or by other methods are sensitive to the specific normalization used on the features. In the context of multivariate pattern analysis using neuroimaging data, standardization effectively up- and down-weights features based on their individual variability. Since the standard approach uses the entire data set to guide the normalization, it utilizes the total variability of these features. This total variation is inevitably dependent on the amount of marginal separation between groups. Thus, such a normalization may attenuate the separability of the data in high dimensional space. In this work we propose an alternate approach that uses an estimate of the control-group standard deviation to normalize features before training. We study our proposed approach in the context of group classification using structural MRI data. We show that control-based normalization leads to better reproducibility of estimated multivariate disease patterns and improves the classifier performance in many cases.

  16. Consistency and Asymptotic Normality of MLE of Parameter Vector in a Randomly Censored GLM with Incomplete Information

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The generalized linear model(GLM) based on the observed data with incomplete information in the case of random censorship is defined. Under the given conditions, the existence and uniqueness of the solution on the likelihood equations with respect to the parameter vector β of the model are discussed, and the consistency and asymptotic normality of the maximum likelihood estimator(MLE) ^βn are proved.

  17. Normal Databases for the Relative Quantification of Myocardial Perfusion.

    Science.gov (United States)

    Rubeaux, Mathieu; Xu, Yuan; Germano, Guido; Berman, Daniel S; Slomka, Piotr J

    2016-08-01

    Myocardial perfusion imaging (MPI) with SPECT is performed clinically worldwide to detect and monitor coronary artery disease (CAD). MPI allows an objective quantification of myocardial perfusion at stress and rest. This established technique relies on normal databases to compare patient scans against reference normal limits. In this review, we aim to introduce the process of MPI quantification with normal databases and describe the associated perfusion quantitative measures that are used. New equipment and new software reconstruction algorithms have been introduced which require the development of new normal limits. The appearance and regional count variations of normal MPI scan may differ between these new scanners and standard Anger cameras. Therefore, these new systems may require the determination of new normal limits to achieve optimal accuracy in relative myocardial perfusion quantification. Accurate diagnostic and prognostic results rivaling those obtained by expert readers can be obtained by this widely used technique. Throughout this review, we emphasize the importance of the different normal databases and the need for specific databases relative to distinct imaging procedures. use of appropriate normal limits allows optimal quantification of MPI by taking into account subtle image differences due to the hardware and software used, and the population studied.

  18. Building an Orthonormal Basis from a 3D Unit Vector Without Normalization

    DEFF Research Database (Denmark)

    Frisvad, Jeppe Revall

    2012-01-01

    I present two tools that save the computation of a dot product and a reciprocal square root in operations that are used frequently in the core of many rendering programs. The first tool is a formula for rotating a direction sampled around the z -axis to a direction sampled around an arbitrary uni...... extracted from the first formula, namely a faster way of building an orthonormal basis from a 3D unit vector. These tools require fewer arithmetic operations than other methods I am aware of, and a performance test of the more general tool confirms that it is faster.......I present two tools that save the computation of a dot product and a reciprocal square root in operations that are used frequently in the core of many rendering programs. The first tool is a formula for rotating a direction sampled around the z -axis to a direction sampled around an arbitrary unit...... vector. This is useful in Monte Carlo rendering techniques, such as path tracing, where directions are usually sampled in spherical coordinates and then transformed to a Cartesian unit vector in a local coordinate system where the zenith direction is the z -axis. The second tool is a more general result...

  19. Design and simulation of optoelectronic complementary dual neural elements for realizing a family of normalized vector 'equivalence-nonequivalence' operations

    Science.gov (United States)

    Krasilenko, Vladimir G.; Nikolsky, Aleksandr I.; Lazarev, Alexander A.; Magas, Taras E.

    2010-04-01

    Equivalence models (EM) advantages of neural networks (NN) are shown in paper. EMs are based on vectormatrix procedures with basic operations of continuous neurologic: normalized vector operations "equivalence", "nonequivalence", "autoequivalence", "autononequivalence". The capacity of NN on the basis of EM and of its modifications, including auto-and heteroassociative memories for 2D images, exceeds in several times quantity of neurons. Such neuroparadigms are very perspective for processing, recognition, storing large size and strongly correlated images. A family of "normalized equivalence-nonequivalence" neuro-fuzzy logic operations on the based of generalized operations fuzzy-negation, t-norm and s-norm is elaborated. A biologically motivated concept and time pulse encoding principles of continuous logic photocurrent reflexions and sample-storage devices with pulse-width photoconverters have allowed us to design generalized structures for realization of the family of normalized linear vector operations "equivalence"-"nonequivalence". Simulation results show, that processing time in such circuits does not exceed units of micro seconds. Circuits are simple, have low supply voltage (1-3 V), low power consumption (milliwatts), low levels of input signals (microwatts), integrated construction, satisfy the problem of interconnections and cascading.

  20. Transverse Vector Vertex Function and Transverse Ward-Takahashi Relations in QED

    Institute of Scientific and Technical Information of China (English)

    HE Han-Xin

    2006-01-01

    The transverse vector vertex function in momentum space in four-dimensional QED is derived in terms of a set of transverse Ward-Takahashi relations for the vector and the axial-vector vertices in the case of massless fermion.It is demonstrated explicitly that the transverse vector vertex function derived this way to one-loop order leads to the same result as one obtained in perturbation theory. This provides a basic approach to determine the transverse part of basic vertex function from the symmetry relations of the system.

  1. Normal forms for germs of vector fields with quadratic leading part. The polynomial first integral case

    Science.gov (United States)

    Stróżyna, Ewa

    2015-12-01

    We study the problem of formal classification of the vector fields of the form x ˙ = ax2 + bxy + cy2 + … , y ˙ = dx2 + exy + fy2 + … using formal changes of the coordinates, but not using the changes of the time. We focus on one special case (which is the most complex one): when the quadratic homogeneous part has a polynomial first integral. In the proofs we avoid complicated calculations. The method we use is effective and it is based on the method introduced in our previous work concerning the Bogdanov-Takens singularity.

  2. [Factors related to perineal trauma in normal births in nulliparous].

    Science.gov (United States)

    Scarabotto, Leila Barreto; Riesco, Maria Luiza Gonzalez

    2006-09-01

    Many studies have been undertaken with the purpose of contributing towards the prevention of perineal trauma in normal birth. The objective of this study was to relate height of the perineum, duration of the second stage of labor, variation of the position of the head detaching, kind of effort, presence of the umbilical cord around the babies' neck, birth weight and vulva's ardor to urinate with the occurrence of perineal laceration. The study was undertaken in 2003 at the Normal Birth Center of the Amparo Maternal, with a sample consisting of 67 women in labor without previous vaginal births. The results demonstrated that there were no significant statistical differences between the variables verified.

  3. A normalized wavefi eld separation cross-correlation imaging condition for reverse time migration based on Poynting vector

    Institute of Scientific and Technical Information of China (English)

    Chen Ting; He Bing-Shou

    2014-01-01

    Prestack reverse time migration (PSTM) is a common imaging method; however low-frequency noises reduce the structural imaging precision. Thus, the suppression of migration noises must be considered. The generation mechanism of low-frequency noises is analyzed and the up-, down-, left-, and right-going waves are separated using the Poynting vector of the acoustic wave equation. The computational complexity and memory capacitance of the proposed method are far smaller than that required when using the conventional separation algorithm of 2D Fourier transform. The normalized wavefield separation cross-correlation imaging condition is used to suppress low-frequency noises in reverse time migration and improve the imaging precision. Numerical experiments using the Marmousi model are performed and the results show that the up-, down-, left-, and right-going waves are well separated in the continuation of the wavefi eld using the Poynting vector. We compared the imaging results with the conventional method, Laplacianfi ltering, and wavefi eld separation with the 2D Fourier transform. The comparison shows that the migration noises are well suppressed using the normalized wavefi eld separation cross-correlation imaging condition and higher precision imaging results are obtained.

  4. The Acquisition of Vector Knowledge and Its Relation to Self-Rated Direction Sense

    Science.gov (United States)

    Muehl, Karen A.; Sholl, M. Jeanne

    2004-01-01

    Self-rated sense of direction is reliably related to people's accuracy when pointing in the direction of unseen landmarks from imagined or actual perspectives. It is proposed that the cognitive substrate of accurate pointing responses is a vector representation, which is defined as an integrated network of displacement vectors. Experiment 1…

  5. Opisodic memory orientation in schizophrenics, their relatives and normal people

    Directory of Open Access Journals (Sweden)

    Gholamali Nikpour

    2017-03-01

    Full Text Available Introduction: Memory is what creates perseverance and continuity in human and everyone's idea about himself depends on the memory. Among different psychological ideas, cognitive psychology is only one which investigated and recognized the memory. It seems mental and spiritual statuses have effects on memory and lead to memory orientation toward specific systems. According to research findings, there are spatial distortions in schizophrenics patients which are equal with main signs of schizophrenia i.e. disorders in the thoughts of these patients. Orientation has basic role to create and process the data same as thoughts in schizophrenics and normal people. Assessing such memory orientation in selecting the direction against pleasant, unpleasant and neutral stimulants is the purpose of current research Methods:   Used data in current study is related to patients and normal people reactions against pleasant, unpleasant and neutral materials of William’s test. After gathering the data, mean, variance and standard deviation were firstly, estimated and were analyzed statistically by independent T test. Results: Findings showed that there was a meaningful relationship between two mean of patients and normal people in reaction against pleasant, unpleasant and neutral stimulants of William’s test. It meaned normal people selected more pleasant stimulants than schizophrenics. Indeed, normal people selected neutral stimulants with slightly more different than schizophrenics. There was not any meaningful difference between normal people and schizophrenics only in unpleasant stimulants. Conclusion: Ability and intellectual coherence lead to mental appropriate performance and will result those people remind all memories particularly unpleasant ones with more details. Therefore it seems that memory orientation process leads to psychological status controlled the individual.

  6. Malaria vector species composition and relative abundance in Mutare and Mutasa districts, Zimbabwe

    Directory of Open Access Journals (Sweden)

    S. Sande

    2015-12-01

    Full Text Available Regular entomological monitoring is important to determine changes in mosquito species composition and relative densities of malaria vectors in relation to vector control interventions. A study to gain insights into malaria vector species composition and relative abundance was undertaken in Mutare and Mutasa districts, Zimbabwe. Two methods; indoor resting catches and larval sampling were used to collect indoor resting adults and larvae from May 2013 to April 2014. Mosquitoes collected as adults and reared from larvae that were identified morphologically as potential malaria vectors were further processed to sibling species by polymerase chain reaction (PCR. Morphological identification of anopheline mosquitoes showed presence of two complexes: An. funestus and An. gambiae. The total number of female members of the An. funestus group and An. gambiae complex collected by both methods from the two sites was 840 and 31 respectively. Malaria vector species of both complexes were more abundant in Mutare than in Mutasa. The PCR-based assays showed the presence of four sibling species: An. funestus sensu stricto (90.8%, 267/294 and An. leesoni (5.1%, 15/294, of An. funestus group; An. arabiensis (41.9%, 13/31 and An. quadriannulatus (48.4%, 15/31 of the An. gambiae complex. About 4% and 5% of specimens of An. gambiae complex and An. funestus group respectively did not amplify. Of the two identified malaria vector sibling species, An. funestus sensu stricto was more abundant (95.4%, 267/280 than An. arabiensis (4.6%, 13/280, suggesting the replacement to secondary vector of An. arabiensis, which was previously the predominant vector species. An. funestus sensu stricto and An. arabiensis, the most important vectors of human malaria were identified in this study, but their resting and biting habits as well as insecticide susceptibility are unclear. Further studies on vector behaviour are therefore recommended.

  7. Relative Position Indicator Concept for Managing Mixed RNAV and Vectored Arrival Traffic Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Mosaic ATM proposes to study a Relative Position Indicator (RPI) concept for managing mixed RNAV and traditionally vectored arrival traffic, to enable increased...

  8. Testing identifiablility of cointegrating vectors

    NARCIS (Netherlands)

    H.P. Boswijk

    1996-01-01

    This article analyzes the identification and normalization of cointegrating vectors. Normalizing a cointegrating relation with respect to one of the relevant variables is with loss of generality; and restrictions that are supposed to identify a vector may fail to do so for particular parameter value

  9. Suppression of gastric cancer growth by baculovirus vector-mediated transfer of normal epithelial cell specific-1 gene

    Institute of Scientific and Technical Information of China (English)

    Wei Huang; Xiang-Long Tian; Yun-Lin Wu; Jie Zhong; Li-Fen Yu; Sheng-Ping Hu; Biao Li

    2008-01-01

    AIM: To study the inhibitory effect of baculovirus-mediated normal epithelial celt specific-1 (NES1) gene therapy on gastric cancer (GC) in vitro and in vivo.METHODS: We first constructed recombinant baculovirus vectors and then transfected them into gastric cancer cells (SGC-7901). Efficiency of the baculovirus for gene transfer into SGC-7901 cells and cell growth curves were detected by fluorescence microscopy, Western blot and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in vitro, respectively. The therapeutic effect of this gene therapy on GC was confirmed in xenografted nude mice. Tumor growth was determined by tumor volume, and expression of NES1 in tumor was analyzed by immunohistochemistry.RESULTS: Baculovirus vectors were successfully transfected into SGC-7901 cells. SGC-7901 cells transfected with the NES1 gene inhibited cell growth. In the Bac-NES1 treated group, tumor growth was significantly reduced with a high level of NES1 expression CONCLUSION: Baculovirus-mediated NES1 gene can be used in gene therapy for GC.

  10. Malaria in Africa: vector species' niche models and relative risk maps.

    Directory of Open Access Journals (Sweden)

    Alexander Moffett

    Full Text Available A central theoretical goal of epidemiology is the construction of spatial models of disease prevalence and risk, including maps for the potential spread of infectious disease. We provide three continent-wide maps representing the relative risk of malaria in Africa based on ecological niche models of vector species and risk analysis at a spatial resolution of 1 arc-minute (9 185 275 cells of approximately 4 sq km. Using a maximum entropy method we construct niche models for 10 malaria vector species based on species occurrence records since 1980, 19 climatic variables, altitude, and land cover data (in 14 classes. For seven vectors (Anopheles coustani, A. funestus, A. melas, A. merus, A. moucheti, A. nili, and A. paludis these are the first published niche models. We predict that Central Africa has poor habitat for both A. arabiensis and A. gambiae, and that A. quadriannulatus and A. arabiensis have restricted habitats in Southern Africa as claimed by field experts in criticism of previous models. The results of the niche models are incorporated into three relative risk models which assume different ecological interactions between vector species. The "additive" model assumes no interaction; the "minimax" model assumes maximum relative risk due to any vector in a cell; and the "competitive exclusion" model assumes the relative risk that arises from the most suitable vector for a cell. All models include variable anthrophilicity of vectors and spatial variation in human population density. Relative risk maps are produced from these models. All models predict that human population density is the critical factor determining malaria risk. Our method of constructing relative risk maps is equally general. We discuss the limits of the relative risk maps reported here, and the additional data that are required for their improvement. The protocol developed here can be used for any other vector-borne disease.

  11. Descriptive vector, relative error matrix, and interaction analysis of multivariable plants

    NARCIS (Netherlands)

    Monshizadeh-Naini, Nima; Fatehi, Alireza; Kahki-Sedigh, Ali

    In this paper, we introduce a vector which is able to describe the Niederlinski Index (NI), Relative Gain array (RGA), and the characteristic equation of the relative error matrix. The spectral radius and the structured singular value of the relative error matrix are investigated. The cases where

  12. Perturbative Correction to Transverse Ward-Takahashi Relation for the Vector Vertex

    Institute of Scientific and Technical Information of China (English)

    HE Han-Xin; YU Hong-Wei

    2003-01-01

    We re-derive exactly the transverse Ward-Takahashi relation for the vector vertex in momentum space.The result shows that this transverse Ward-Takahashi relation in momentum space involves a perturbative correction term. We demonstrate explicitly that this transverse Ward-Takahashi relation is satisfied indeed at one-loop order.

  13. Relating normalization to neuronal populations across cortical areas.

    Science.gov (United States)

    Ruff, Douglas A; Alberts, Joshua J; Cohen, Marlene R

    2016-09-01

    Normalization, which divisively scales neuronal responses to multiple stimuli, is thought to underlie many sensory, motor, and cognitive processes. In every study where it has been investigated, neurons measured in the same brain area under identical conditions exhibit a range of normalization, ranging from suppression by nonpreferred stimuli (strong normalization) to additive responses to combinations of stimuli (no normalization). Normalization has been hypothesized to arise from interactions between neuronal populations, either in the same or different brain areas, but current models of normalization are not mechanistic and focus on trial-averaged responses. To gain insight into the mechanisms underlying normalization, we examined interactions between neurons that exhibit different degrees of normalization. We recorded from multiple neurons in three cortical areas while rhesus monkeys viewed superimposed drifting gratings. We found that neurons showing strong normalization shared less trial-to-trial variability with other neurons in the same cortical area and more variability with neurons in other cortical areas than did units with weak normalization. Furthermore, the cortical organization of normalization was not random: neurons recorded on nearby electrodes tended to exhibit similar amounts of normalization. Together, our results suggest that normalization reflects a neuron's role in its local network and that modulatory factors like normalization share the topographic organization typical of sensory tuning properties.

  14. Equivalent Relation between Normalized Spatial Entropy and Fractal Dimension

    CERN Document Server

    Chen, Yanguang

    2016-01-01

    Fractal dimension is defined on the base of entropy, including macro state entropy and information entropy. The generalized dimension of multifractals is based on Renyi entropy. However, the mathematical transform from entropy to fractal dimension is not yet clear in both theory and practice. This paper is devoted to revealing the equivalence relation between spatial entropy and fractal dimension using box-counting method. Based on varied regular fractals, the numerical relationship between spatial entropy and fractal dimension is examined. The results show that the ratio of actual entropy (Mq) to the maximum entropy (Mmax) equals the ratio of actual dimension (Dq) to the maximum dimension (Dmax), that is, Mq/Mmax=Dq/Dmax. For real systems, the spatial entropy and fractal dimension of complex spatial systems such as cities can be converted into one another by means of functional box-counting method. The theoretical inference is verified by observational data of urban form. A conclusion is that normalized spat...

  15. Current Knowledge of Leishmania Vectors in Mexico: How Geographic Distributions of Species Relate to Transmission Areas

    Science.gov (United States)

    González, Camila; Rebollar-Téllez, Eduardo A.; Ibáñez-Bernal, Sergio; Becker-Fauser, Ingeborg; Martínez-Meyer, Enrique; Peterson, A. Townsend; Sánchez-Cordero, Víctor

    2011-01-01

    Leishmaniases are a group of vector-borne diseases with different clinical manifestations caused by parasites transmitted by sand fly vectors. In Mexico, the sand fly Lutzomyia olmeca olmeca is the only vector proven to transmit the parasite Leishmania mexicana to humans, which causes leishmaniasis. Other vector species with potential medical importance have been obtained, but their geographic distributions and relation to transmission areas have never been assessed. We modeled the ecological niches of nine sand fly species and projected niches to estimate potential distributions by using known occurrences, environmental coverages, and the algorithms GARP and Maxent. All vector species were distributed in areas with known recurrent transmission, except for Lu. diabolica, which appeared to be related only to areas of occasional transmission in northern Mexico. The distribution of Lu. o. olmeca does not overlap with all reported cutaneous leishmaniasis cases, suggesting that Lu. cruciata and Lu. shannoni are likely also involved as primary vectors in those areas. Our study provides useful information of potential risk areas of leishmaniasis transmission in Mexico. PMID:22049037

  16. Segmentation of Planar Surfaces from Laser Scanning Data Using the Magnitude of Normal Position Vector for Adaptive Neighborhoods.

    Science.gov (United States)

    Kim, Changjae; Habib, Ayman; Pyeon, Muwook; Kwon, Goo-rak; Jung, Jaehoon; Heo, Joon

    2016-01-22

    Diverse approaches to laser point segmentation have been proposed since the emergence of the laser scanning system. Most of these segmentation techniques, however, suffer from limitations such as sensitivity to the choice of seed points, lack of consideration of the spatial relationships among points, and inefficient performance. In an effort to overcome these drawbacks, this paper proposes a segmentation methodology that: (1) reduces the dimensions of the attribute space; (2) considers the attribute similarity and the proximity of the laser point simultaneously; and (3) works well with both airborne and terrestrial laser scanning data. A neighborhood definition based on the shape of the surface increases the homogeneity of the laser point attributes. The magnitude of the normal position vector is used as an attribute for reducing the dimension of the accumulator array. The experimental results demonstrate, through both qualitative and quantitative evaluations, the outcomes' high level of reliability. The proposed segmentation algorithm provided 96.89% overall correctness, 95.84% completeness, a 0.25 m overall mean value of centroid difference, and less than 1° of angle difference. The performance of the proposed approach was also verified with a large dataset and compared with other approaches. Additionally, the evaluation of the sensitivity of the thresholds was carried out. In summary, this paper proposes a robust and efficient segmentation methodology for abstraction of an enormous number of laser points into plane information.

  17. Segmentation of Planar Surfaces from Laser Scanning Data Using the Magnitude of Normal Position Vector for Adaptive Neighborhoods

    Directory of Open Access Journals (Sweden)

    Changjae Kim

    2016-01-01

    Full Text Available Diverse approaches to laser point segmentation have been proposed since the emergence of the laser scanning system. Most of these segmentation techniques, however, suffer from limitations such as sensitivity to the choice of seed points, lack of consideration of the spatial relationships among points, and inefficient performance. In an effort to overcome these drawbacks, this paper proposes a segmentation methodology that: (1 reduces the dimensions of the attribute space; (2 considers the attribute similarity and the proximity of the laser point simultaneously; and (3 works well with both airborne and terrestrial laser scanning data. A neighborhood definition based on the shape of the surface increases the homogeneity of the laser point attributes. The magnitude of the normal position vector is used as an attribute for reducing the dimension of the accumulator array. The experimental results demonstrate, through both qualitative and quantitative evaluations, the outcomes’ high level of reliability. The proposed segmentation algorithm provided 96.89% overall correctness, 95.84% completeness, a 0.25 m overall mean value of centroid difference, and less than 1° of angle difference. The performance of the proposed approach was also verified with a large dataset and compared with other approaches. Additionally, the evaluation of the sensitivity of the thresholds was carried out. In summary, this paper proposes a robust and efficient segmentation methodology for abstraction of an enormous number of laser points into plane information.

  18. The Ideal of Relations of a Ring of Highest Weight Vectors

    Institute of Scientific and Technical Information of China (English)

    Shaoqiang Deng; Zixin Hou

    2001-01-01

    We use the slice method and some computer algebra programs to determine the ideal of relations of the ring of highest weight vectors of the action of Om and GL3 on the algebra of complex polynomials on Cm,3 with m ≥ 6.

  19. Molecular biological approaches to the study of vectors in relation to malaria control

    Directory of Open Access Journals (Sweden)

    J. M. Crampton

    1992-01-01

    Full Text Available To a large extent, control of malaria vectors relies on the elimination of breeding sites and the application of chemical agents. There are increasing problems associated with the use of synthetic insecticides for vector control, including the evolution of resistance, the high cost of developing and registering new insecticides and an awareness of pollution from insecticide residues. These factors have stimulated interest in the application of molecular biology to the study of mosquito vectors of malaria; focussing primarily on two aspects. First, the improvement of existing control measures through the development of simplified DNA probe systems suitable for identification of vectors of malaria. The development of synthetic, non-radioactive DNA probes suitable for identification of species in the Anopheles gambiae complex is described with the aim of defining a simplified methodology wich is suitable for entomologist in the field. The second aspect to be considered is the development of completely novel strategies through the development of completely novel strategies through the genetic manipulation of insect vectors of malaria in order to alter their ability to transmit the disease. The major requirements for producing transgenic mosquitoes are outlined together with the progress wich has been made to date and discussed in relation to the prospects which this type of approach has for the future control of malaria.

  20. Abundance of West Nile virus mosquito vectors in relation to climate and landscape variables.

    Science.gov (United States)

    Deichmeister, Jayne M; Telang, Aparna

    2011-06-01

    It is currently unclear if the potential for West Nile virus transmission by mosquito vectors in the eastern United States is related to landscape or climate factors or both. We compared abundance of vector species between urban and suburban neighborhoods of Henrico County, VA, in relation to the following factors: temperature, precipitation, canopy cover, building footprint, and proximity to drainage infrastructure. Mosquitoes were collected throughout the 2005, 2006, and 2007 seasons and tested for West Nile virus (WNV) in pools of 10-50. Test results of mosquito pools were compared to average site abundance from 37 sites in Henrico County, VA; abundance was then examined in relation to ecological variables. Urban infrastructure was positively correlated with the abundance of Culex pipiens L./Cx. restuans, and our findings implicate combined sewer overflow systems as large contributors to Culex vector populations. No measure of urbanization examined in our study was correlated with Aedes albopictus abundance. Our study showed that certain landscape variables identified using Geographic Information Systems are valuable for predicting primary WNV vector abundance in Virginia, and that temperature along with low precipitation are strong predictors of population growth. Our results support other regional studies that found WNV proliferates under drought conditions.

  1. Normal values for plasma creatinine concentration related to maturity in normal term and preterm infants.

    Science.gov (United States)

    Trompeter, R S; Al-Dahhan, J; Haycock, G B; Chik, G; Chantler, C

    1983-09-01

    Creatinine concentration was measured by a kinetic method in 475 plasma samples obtained from 260 term and preterm infants during the first 2 months post-natal age. In term infants plasma creatinine fell from 88 +/- 4.4 mumol/L (mean + SEM) at birth, to 60 +/- 1.9 mumol/L by the fourth day remaining stable thereafter; in preterm infants creatinine fell to 86 +/- 7 mumol/L by the fourth day. Analysis of pooled data from all infants of more than 4 days post natal age revealed a progressive fall in creatinine with increasing post conceptual age. The normal range of values varies with post conceptual age and was not influenced by gestational age at the time of birth.

  2. Fermi Normal Coordinates and Fermion Curvature Couplings in General Relativity

    CERN Document Server

    Dey, Anshuman; Sarkar, Tapobrata

    2014-01-01

    We study gravitational curvature effects in circular and radial geodesics in static, spherically symmetric space-times, using Fermi normal coordinates. We first set up these coordinates in the general case, and then use this to study effective magnetic fields due to gravitational curvature in the exterior and interior Schwarzschild, Janis-Newman-Winicour, and Bertrand space-times. We show that these fields can be large for specific parameter values in the theories, and thus might have observational significance. We discuss the qualitative differences of the magnetic field for vacuum space-times and for those seeded by matter. We estimate the magnitude of these fields in realistic galactic scenarios and discuss their possible experimental relevance. Gravitational curvature corrections to the Hydrogen atom spectrum for these space-times are also discussed briefly.

  3. Normalized Relational Storage for Extensible Markup Language (XML Schema

    Directory of Open Access Journals (Sweden)

    Kamsuriah Ahmad

    2011-01-01

    Full Text Available Problem statement: The use of XML as the common formats for representing, exchanging, storing, integrating and accessing data posses many new challenges to database systems. Most of application data are stored in relational databases due to its popularity and rich development experiences over it. Therefore, how to provide a proper mapping approach from XML model to relational model become the major research problems. Current techniques for managing XML in relational technology consider only the structure of an XML document and ignore its semantics as expressed by keys and functional dependencies. Approach: In this study we present an algorithm for generating an optimal design for XML in relational setting. The algorithm is based on computing a set of minimum covers for all functional dependencies on a universal relation when given XML Functional Dependencies (XFDs and the schema information. However we need to deal with the hierarchical nature of XML and to define XFDs in this structure. Results: We show that our algorithm is efficient in terms of reducing data redundancy and preserving semantic expression. Conclusion/Recommendations: Being able to infer XML functional dependencies constraints to relational views of XML data is a first step towards establishing a connection between XML and its relational representation at the semantic level.

  4. The Suyama-Yamaguchi consistency relation in the presence of vector fields

    CERN Document Server

    Almeida, Juan P Beltran; Valenzuela-Toledo, Cesar A

    2011-01-01

    We consider inflationary models in which vector fields are responsible for part or eventually all of the primordial curvature perturbation \\zeta. Such models are phenomenologically interesting since they naturally introduce anisotropies in the probability distribution function of the primordial fluctuations that can leave a measurable imprint in the cosmic microwave background. Assuming that non-Gaussianity is generated due to the superhorizon evolution, we use the \\delta N formalism to do a complete tree level calculation of the non-Gaussianity parameters f_{NL} and \\tau_{NL} in the presence of vector fields. We isolate the isotropic pieces of the non-Gaussianity parameters, which anyway have contributions from the vector fields, and show that they obey the Suyama-Yamaguchi consistency relation \\tau^{iso}_{NL}>=(6/5f^{iso}_{NL})^2. Other ways of defining the non-Gaussianity parameters, which could be observationally relevant, are stated and the respective Suyama-Yamaguchi-like consistency relations are obtai...

  5. Elk Distributions Relative to Spring Normalized Difference Vegetation Index Values

    Directory of Open Access Journals (Sweden)

    Samuel T. Smallidge

    2010-01-01

    Full Text Available Rocky Mountain elk (Cervus elaphus that winter near San Antonio Mountain in northern New Mexico provide important recreational and economic benefits while creating management challenges related to temporospatial variation in their spring movements. Our objective was to examine spring distributions of elk in relation to vegetative emergence as it progresses across the landscape as measured by remote sensing. Spring distributions of elk were closely associated with greater photosynthetic activity of spring vegetation in 2 of 3 years as determined using NDVI values derived from AVHRR datasets. Observed elk locations were up to 271% greater than expected in the category representing the most photosynthetic activity. This association was not observed when analyses at a finer geographic scale were conducted. Managers facing challenges involving human-wildlife interactions and land-use issues should consider environmental conditions that may influence variation in elk association with greener portions of the landscape.

  6. Adeno-Associated Vector mediated gene transfer of Transforming Growth Factor-beta1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism

    Directory of Open Access Journals (Sweden)

    Ulrich-Vinther M.

    2005-11-01

    Full Text Available The objective of the present study was to investigate whether cartilage anabolism in human primary osteoarthritic chondrocytes could be improved by adeno-associated virus (AAV vector-mediated gene transduction of transforming growth factor TGF-beta1 (TGF-beta1. A bi-cistronic AAV-TGF-beta1-IRES-eGFP (AAV-TGF-beta1 vector was generated and used for transduction of a normal human articular chondrocyte cell line (tsT/AC62 and primary human osteoarthritic articular chondrocytes harvested from 8 patients receiving total knee joint arthroplasty. Transduction efficiency was detected by fluorescent microscopy for gene expression of enhanced green fluorescent protein (eGFP. TGF-beta1 synthesis was determined by ELISA. To assess the influence of TGF-beta1 gene therapy on chondrocyte cartilage metabolism, mRNA expressions of type II collagen, aggrecan, and matrix metalloproteinase 3 (MMP-3 were determined by quantitative real-time PCR. AAV-TGF-beta1 transduction resulted in increased synthesis of TGF-beta1 in both osteoarthritic chondrocytes and the normal articular chondrocyte cell line. The expression levels of the transduced genes were correlated to "multiplicity of infection" (MOI and post-infectious time. In both osteoarthritic chondrocytes and the normal articular chondrocyte cell line, AAV-TGF-beta1 treatment increased mRNA expression of both type II collagen and aggrecan, but decreased MMP-3 mRNA expression. Osteoarthritic chondrocytes and the normal articular chondrocyte cell line could be transduced with equal efficiencies. In conclusion, it was demonstrated that AAV-TGF-beta1 gene transfer stimulates cartilage anabolism and decreases expression of enzymes responsible for cartilage degradation in human osteoarthritic chondrocytes. The results indicate that the AAV vector is an efficient mediator of growth factors to human articular chondrocytes, and that it might be useful in future chondrocyte gene therapy.

  7. Polynomial Tests of Normal Forms and Some Related Results

    Institute of Scientific and Technical Information of China (English)

    王克

    1992-01-01

    The following problem is called the everywhere-cover problem:“Given a set of dependencies over a database scheme,is he set of dependencies explicitly given for each relation scheme equivalent to the dependencies implied for that relation sheme?”It is shown that when the everywhere-cover problem has a yes answer,examining only the dependencies explicitly given will suffice to test 3NF, BCNF and 4NF of a database scheme.But this does not hold for 2NF.Consequently,in such cases,tests of BCNF and 4NF all take polynomial time.Then a proof is given that test of 3NF of a database scheme is Co-NP-complete,and from this result it is shown that everywhere-cover is also Co-NP-complete when only functional dependencies are allowed.These results lead to doubt the truth of the well believed conjecture that no polynomial time algorithm for designing a lossless BCNF database scheme is likely to exist.

  8. Characteristics and Nonlinear Growth of the Singular Vector Related to a Heavy Rainfall Case over the Korean Peninsula

    Institute of Scientific and Technical Information of China (English)

    Yonghan CHOI; Joowan KIM; Dong-Kyou LEE

    2012-01-01

    In this study,singular vectors related to a heavy rainfall case over the Korean Peninsula were calculated using the fifth-generation Pennsylvania State University-National Center for Atmospheric Research Mesoscale Model (MM5) adjoint modeling system.Tangent linear and adjoint models include moist physical processes,and a moist basic state and a moist total energy norm were used for the singular-vector calculations.The characteristics and nonlinear growth of the first singular vector were analyzed,focusing on the relationship between the basic state and the singular vector.The horizontal distribution of the initial singular vector was closely related to the baroclinicity index and the moisture availability of the basic state.The temperature-component energy at a lower level was dominant at the initial time,and the kinetic energy at upper levels became dominant at the final time in the energy profile of the singular vector.The nonlinear growth of the singular vector appropriately reflects the temporal variations in the basic state.The moisture-component energy at lower levels was dominant at earlier times,indicating continuous moisture transport in the basic state.There were a large amount of precipitation and corresponding latent heat release after that period because the continuous moisture transport created favorable conditions for both convective and nonconvective precipitation.The vertical propagation of the singular-vector energy was caused by precipitation and the corresponding latent heating in the basic state.

  9. 一般形式下斜正态随机向量的矩%Moments of the Skew Normal Random Vectors in the General Case

    Institute of Scientific and Technical Information of China (English)

    方碧琪

    2008-01-01

    In this paper,we derived the moments of the random vectors with the skew normal distributions and their quadratic forms in the general case.As an application,the measures of multivariate skewness and kurtosm are calculated.%本文给出一般形式下斜正态随机向量及其平方型的矩公式.作为应用,计算出了斜正态随机向量的多元偏度和峰度.

  10. Scientists and public involvement: a consultation on the relation between malaria, vector control and transgenic mosquitoes.

    Science.gov (United States)

    Boëte, Christophe

    2011-12-01

    Among the hopes for vector-based malaria control, the use of transgenic mosquitoes able to kill malaria parasites is seen as a potential way to interrupt malaria transmission. While this potential solution is gaining some support, the ethical and social aspects related to this high-tech method remain largely unexplored and underestimated. Related to those latter points, the aim of the present survey is to determine how scientists working on malaria and its vector mosquitoes perceive public opinion and how they evaluate public consultations on their research. This study has been performed through a questionnaire addressing questions related to the type of research, the location, the nationality and the perception of the public involvement by scientists. The results suggest that even if malaria researchers agree to interact with a non-scientific audience, they (especially the ones from the global North) remain quite reluctant to have their research project submitted in a jargon-free version to the evaluation and the prior-agreement by a group of non-specialists. The study, by interrogating the links between the scientific community and the public from the perspective of the scientists, reveals the importance of fostering structures and processes that could lead to a better involvement of a non specialist public in the actual debates linking scientific, technological and public health issues in Africa.

  11. Estimating the temporal and spatial risk of bluetongue related to the incursion of infected vectors into Switzerland

    Directory of Open Access Journals (Sweden)

    Griot C

    2008-10-01

    Full Text Available Abstract Background The design of veterinary and public health surveillance systems has been improved by the ability to combine Geographical Information Systems (GIS, mathematical models and up to date epidemiological knowledge. In Switzerland, an early warning system was developed for detecting the incursion of the bluetongue disease virus (BT and to monitor the frequency of its vectors. Based on data generated by this surveillance system, GIS and transmission models were used in order to determine suitable seasonal vector habitat locations and risk periods for a larger and more targeted surveillance program. Results Combined thematic maps of temperature, humidity and altitude were created to visualize the association with Culicoides vector habitat locations. Additional monthly maps of estimated basic reproduction number transmission rates (R0 were created in order to highlight areas of Switzerland prone to higher BT outbreaks in relation to both vector activity and transmission levels. The maps revealed several foci of higher risk areas, especially in northern parts of Switzerland, suitable for both vector presence and vector activity for 2006. Results showed a variation of R0 values comparing 2005 and 2006 yet suggested that Switzerland was at risk of an outbreak of BT, especially if the incursion arrived in a suitable vector activity period. Since the time of conducting these analyses, this suitability has proved to be the case with the recent outbreaks of BT in northern Switzerland. Conclusion Our results stress the importance of environmental factors and their effect on the dynamics of a vector-borne disease. In this case, results of this model were used as input parameters for creating a national targeted surveillance program tailored to both the spatial and the temporal aspect of the disease and its vectors. In this manner, financial and logistic resources can be used in an optimal way through seasonally and geographically adjusted

  12. Seasonal relationship between normalized difference vegetation index and abundance of the Phlebotomus kala-azar vector in an endemic focus in Bihar, India

    Directory of Open Access Journals (Sweden)

    Gouri S. Bhunia

    2012-11-01

    Full Text Available Remote sensing was applied for the collection of spatio-temporal data to increase our understanding of the potential distribution of the kala-azar vector Phlebotomus argentipes in endemic areas of the Vaishali district of Bihar, India. We produced monthly distribution maps of the normalized difference vegetation index (NDVI based on data from the thematic mapper (TM sensor onboard the Landsat-5 satellite. Minimum, maximum and mean NDVI values were computed for each month and compared with the concurrent incidence of kala-azar and the vector density. Maximum and mean NDVI values (R2 = 0.55 and R2 = 0.60, respectively, as well as the season likelihood ratio (X2 = 17.51; P <0.001, were found to be strongly associated with kala-azar, while the correlation with between minimum NDVI values and kala-azar was weak (R2 = 0.25. Additionally, a strong association was found between the mean and maximum NDVI values with seasonal vector abundance (R2 = 0.60 and R2 = 0.55, respectively but there was only a marginal association between minimum NDVI value and the spatial distribution of kala-azar vis-à-vis P. argentipes density.

  13. Balancing relations between the normalized left and right coprime factorizations of a nonlinear system

    NARCIS (Netherlands)

    Scherpen, Jacquelien M.A.

    2006-01-01

    This paper considers the relation between the singular value functions of the nonlinear normalized left coprime factorization (NLCF) and the nonlinear normalized right coprime factorization (NRCF). In previous work a new duality notion gave rise to a relation between the controllability, observabili

  14. Assessing the relative importance of climate variables to rice yield variation using support vector machines

    Science.gov (United States)

    Chen, Hui; Wu, Wei; Liu, Hong-Bin

    2016-10-01

    Climate factors have distinct impacts on crop yields. Understanding the relative importance of these factors to crop yield variation could provide valuable information about crop planting and management under climate change condition for policymakers and farmers. The current study investigated the applicability of support vector machines (SVMs) in determining the relative importance of climate factors (mean temperature, rainfall, relative humidity, sunshine hours, daily temperature range, and rainy days) to yield variation of paddy rice in southwestern China. The SVM models were compared with traditional artificial neural networks and multiple linear regression. The performance accuracy was evaluated by mean absolute error (MAE), mean relative absolute error (MRAE), root mean square error (RMSE), relative root mean square error (RRMSE), and coefficient of determination ( R 2). Comparative results showed that SVMs outperformed artificial neural networks and multiple linear regression. The SVM with radial basis function performed best with MAE of 0.06 t ha-1, MRAE of 0.9 %, RMSE of 0.15 t ha-1, RRMSE of 2.23 %, and R 2 of 0.94. The results showed that SVMs are suitable for determining the effects of climate on crop yield variability. The relative importance of the studied climate factors to rice yield variation was in order of sunshine hours > daily temperature range > rainfall > relative humidity > mean temperature > rainy days in the current study area.

  15. Control of vectors through interference with normal processes of insect physiology, reproduction and behavior. Final report 1968-1976

    Energy Technology Data Exchange (ETDEWEB)

    Schermeister, L.J.; Sandal, P.C.; Frye, R.D.

    1978-04-01

    Over 3000 crude water, alcohol and pet-ether plant part extracts were bioassayed with mosquitoes and Drosophila in an effort to identify agents which specifically interfere with insect metamorphosis, and which could provide environmentally safe insect control. About 10% of the extracts modified metamorphosis. Juvenile hormone type activity was noted in some extracts. Preliminary fractionation of promising extracts revealed fractions-bioassay results similar to that of the crude extracts. Exact nature of active fractions was not fully determined; however, flavanoids, alkaloids, and glycosides were suggested. Other agents including teratogens, hormones, and chemosterilant apholate, and gamma-radiation showed promise as potential vector control agents. Wing movements, sound patterns, and population dynamics of mosquitoes were studied as a step toward developing insect behavior and confusion and surveillance techniques. Transmission electron microscopy revealed the morphological nature of the cuticle layer of mosquito but additional studies are needed to understand chemical penetration of the cuticle. The septum of mosquito testes was found to be layered and surrounded by mitochondria. Ovaries were cultured on artificial media and a stain for neurosecretory activity was developed. Synthesis of Difluroperazine dihydro chloride and position labeling was achieved.

  16. Responses to rotating linear acceleration vectors considered in relation to a model of the otolith organs. [human oculomotor response to transverse acceleration stress

    Science.gov (United States)

    Benson, A. J.; Barnes, G. R.

    1973-01-01

    Human subjects were exposed to a linear acceleration vector that rotated in the transverse plane of the skull without angular counterrotation. Lateral eye movements showed a sinusoidal change in slow phase velocity and an asymmetry or bias in the same direction as vector rotation. A model is developed that attributes the oculomotor response to otolithic mechanisms. It is suggested that the bias component is the manifestation of torsion of the statoconial plaque relative to the base of the utricular macula and that the sinusoidal component represents the translational oscillation of the statoconia. The model subsumes a hypothetical neural mechanism which allows x- and y-axis accelerations to be resolved. Derivation of equations of motion for the statoconial plaque in torsion and translation, which take into account forces acting in shear and normal to the macula, yield estimates of bias and sinusoidal components that are in qualitative agreement with the diverse experimental findings.

  17. Early mammalian development under conditions of reorientation relative to the gravity vector

    Science.gov (United States)

    Wolgemuth, D. J.; Grills, G. S.

    1985-01-01

    A clinostat was used to assess the effects of reorientation relative to the gravity vector on mammalian germ cells cultured in vitro. Previous studies using this system revealed an inhibition of meiotic maturation of mouse oocytes. In the present study, the effects of clinostat rotation on in vitro fertilization were examined. The frequency of fertilization of experimental cultures did not vary from that of the clinostat vertical control cultures at either of the rotation rates examined. Importantly, no abnormalities of fertilization, such as parthenogenetic activation, fragmentation, or polyspermy were seen. It is concluded that the initial events of fertilization were unaffected by this treatment, although the developmental potential of these embryos remains to be assessed.

  18. Change in Hamiltonian general relativity from the lack of a time-like Killing vector field

    Science.gov (United States)

    Pitts, J. Brian

    2014-08-01

    In General Relativity in Hamiltonian form, change has seemed to be missing, defined only asymptotically, or otherwise obscured at best, because the Hamiltonian is a sum of first-class constraints and a boundary term and thus supposedly generates gauge transformations. Attention to the gauge generator G of Rosenfeld, Anderson, Bergmann, Castellani et al., a specially tuned sum of first-class constraints, facilitates seeing that a solitary first-class constraint in fact generates not a gauge transformation, but a bad physical change in electromagnetism (changing the electric field) or General Relativity. The change spoils the Lagrangian constraints, Gauss's law or the Gauss-Codazzi relations describing embedding of space into space-time, in terms of the physically relevant velocities rather than auxiliary canonical momenta. While Maudlin and Healey have defended change in GR much as G. E. Moore resisted skepticism, there remains a need to exhibit the technical flaws in the no-change argument. Insistence on Hamiltonian-Lagrangian equivalence, a theme emphasized by Mukunda, Castellani, Sugano, Pons, Salisbury, Shepley and Sundermeyer among others, holds the key. Taking objective change to be ineliminable time dependence, one recalls that there is change in vacuum GR just in case there is no time-like vector field ξα satisfying Killing's equation £ξgμν = 0, because then there exists no coordinate system such that everything is independent of time. Throwing away the spatial dependence of GR for convenience, one finds explicitly that the time evolution from Hamilton's equations is real change just when there is no time-like Killing vector. The inclusion of a massive scalar field is simple. No obstruction is expected in including spatial dependence and coupling more general matter fields. Hence change is real and local even in the Hamiltonian formalism. The considerations here resolve the Earman-Maudlin standoff over change in Hamiltonian General Relativity: the

  19. THE RELATION BETWEEN DIMENSIONS OF NORMAL AND PATHOLOGICAL PERSONALITY AND CHILDHOOD MALTREATMENT IN INCARCERATED BOYS

    NARCIS (Netherlands)

    E. Nederlof; J.M. van der Ham; P.M.J.A. Dingemans; T.I. Oei

    2010-01-01

    The relation between subtypes of maltreatment and dimensions of personality and personality pathology was investigated in a representative sample of 142 incarcerated Dutch male juveniles. Normal personality dimensions were assessed with the Big Five Inventory, the Dimensional Assessment of Personali

  20. Age-related changes of normal adult brain structure: analysed with diffusion tensor imaging

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yun-ting; ZHANG Chun-yan; ZHANG Jing; LI Wei

    2005-01-01

    Background It is known that the brain structure changes with normal aging. The objective of this study was to quantify the anisotropy and average diffusion coefficient (DCavg) of the brain in normal adults to demonstrate the microstructure changes of brain with aging.Methods One hundred and six normal adults were examined with diffusion tensor imaging (DTI). The fractional anisotropy (FA), 1-volume ratio (1-VR), relative anisotropy (RA) and average diffusion coefficient (DCavg) of different anatomic sites of brain were measured, correlated with age and compared among three broad age groups.Results Except in lentiform nucleus, the anisotropy increased and DCavg decreased with aging. Both anisotropy and DCavg of lentiform nucleus increased with aging. The normal reference values of DTI parameters of normal Chinese adult in major anatomic sites were acquired. Conclusions DTI data obtained noninvasively can reflect the microstructural changes with aging. The normal reference values acquired can serve as reference standards in differentiation of brain white matter diseases.

  1. Characterization of Non-Linearized Spacecraft Relative Motion using Nonlinear Normal Modes

    Science.gov (United States)

    2016-04-20

    Non-Linearized Spacecraft Relative Motion using Nonlinear Normal Modes 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 62601F...AFRL-RV-PS- AFRL-RV-PS- TR-2015-0182 TR-2015-0182 CHARACTERIZATION OF NON-LINEARIZED SPACECRAFT RELATIVE MOTION USING NONLINEAR NORMAL MODES Eric...STATEMENT. THOMAS LOVELL PAUL HAUSGEN, Ph.D. Program Manager Technical Advisor, Spacecraft Component Technology JOHN BEAUCHEMIN Chief Engineer

  2. Vector fields on nonorientable surfaces

    Directory of Open Access Journals (Sweden)

    Dorin Ghisa

    2003-01-01

    Full Text Available A one-to-one correspondence is established between the germs of functions and tangent vectors on a NOS X and the bi-germs of functions, respectively, elementary fields of tangent vectors (EFTV on the orientable double cover of X. Some representation theorems for the algebra of germs of functions, the tangent space at an arbitrary point of X, and the space of vector fields on X are proved by using a symmetrisation process. An example related to the normal derivative on the border of the Möbius strip supports the nontriviality of the concepts introduced in this paper.

  3. Event-Related EEG Oscillations to Semantically Unrelated Words in Normal and Learning Disabled Children

    Science.gov (United States)

    Fernandez, Thalia; Harmony, Thalia; Mendoza, Omar; Lopez-Alanis, Paula; Marroquin, Jose Luis; Otero, Gloria; Ricardo-Garcell, Josefina

    2012-01-01

    Learning disabilities (LD) are one of the most frequent problems for elementary school-aged children. In this paper, event-related EEG oscillations to semantically related and unrelated pairs of words were studied in a group of 18 children with LD not otherwise specified (LD-NOS) and in 16 children with normal academic achievement. We propose that…

  4. Relative pressure imaging in left ventricle using ultrasonic vector flow mapping

    Science.gov (United States)

    Tanaka, Tomohiko; Okada, Takashi; Nishiyama, Tomohide; Seki, Yoshinori

    2017-07-01

    Ultrasonic relative pressure imaging (RPI) visualizing pressure distribution on the basis of vector flow mapping (VFM) was developed by applying the momentum equations of fluid motion (Navier-Stokes equations; NSE) for the two-dimensional (2D)-VFM velocity fields. Numerical investigations using three-dimensional (3D) jets with a size similar to the left ventricle (LV) quantified degradations caused by the flow three-dimensionality of convection in the range of 0.1 mmHg. Experimental validation using an LV phantom quantitatively compared two-point intraventricular pressure differences (IVPDs) obtained by RPI, two pressure sensors (grand truth), and color M-mode (CMM) with a high frame rate of 167 Hz in diastole where a transient term is dominant. All measurements of IVPDs in diastole were in good agreement, although the peak value of IVPD by RPI was underestimated by about 35%, mainly because of its insufficient frame rate of 35 Hz. A dependence of the frame rate on IVPD was examined by down-sampled CMM. Although IVPD based on down-sampled CMM at 27 Hz similar to that of the current RPI frame rate showed that the accuracy was underestimated by 30%, a higher data rate of more than 60 Hz, which could be realized in the near future, provided reasonable accuracy with less than 10% error.

  5. Modeling personalized head-related impulse response using support vector regression

    Institute of Scientific and Technical Information of China (English)

    HUANG Qing-hua; FANG Yong

    2009-01-01

    A new customization approach based on support vector regression (SVR) is proposed to obtain individual headrelated impulse response (HRIR) without complex measurement and special equipment. Principal component analysis (PCA) is first applied to obtain a few principal components and corresponding weight vectors correlated with individual anthropometric parameters. Then the weight vectors act as output of the nonlinear regression model. Some measured anthropometric parameters are selected as input of the model according to the correlation coefficients between the parameters and the weight vectors. After the regression model is learned from the training data, the individual HRIR can be predicted based on the measured anthropometric parameters. Compared with a back-propagation neural network (BPNN) for nonlinear regression,better generalization and prediction performance for small training samples can be obtained using the proposed PCA-SVR algorithm.

  6. gamma. -->. 3. pi. coupling constant, the Goldberger-Treiman relation, vector mesons and the. omega. -->. 3. pi. contact term

    Energy Technology Data Exchange (ETDEWEB)

    Lahiri, A.; Bagchi, B.

    1987-07-01

    The recent experimental measurement of the ..gamma.. ..-->.. 3..pi.. coupling constant is compared with the prediction of an extended PCAC hypothesis. Consistency is then sought between the ..omega..rho..pi.. coupling constant, as obtained from an analogue of the GT relation for vector mesons, and what is predicted by the low-energy theorems.

  7. Towards a risk map of malaria for Sri Lanka: the importance of house location relative to vector breeding sites

    DEFF Research Database (Denmark)

    Van Der Hoek, Wim; Konradsen, Flemming; Amerasinghe, Priyanie H

    2003-01-01

    collections. RESULTS: People living within 750 m of the local stream, which was the established vector-breeding site, were at much higher risk for malaria than people living further away (odds ratio adjusted for confounding by other variables 5.93, 95% CI: 3.50-8.91). Houses close to the stream also had more......BACKGROUND: In Sri Lanka, the major malaria vector Anopheles culicifacies breeds in pools formed in streams and river beds and it is likely that people living close to such breeding sites are at higher risk of malaria than people living further away. This study was done to quantify the importance...... of house location relative to vector breeding sites for the occurrence of malaria in order to assess the usefulness of this parameter in future malaria risk maps. Such risk maps could be important tools for planning efficient malaria control measures. METHODS: In a group of seven villages in north central...

  8. 二次B样条曲面顶点及法向插值%Interpolation of Vertices and Their Normal Vectors with Quadratic B-Spline Surfaces

    Institute of Scientific and Technical Information of China (English)

    李桂清; 李现民; 李华

    2001-01-01

    Interpolation to vertex positions is an essential issue in surface modeling, and interpolation to normal vectors has also important applications in some CAD/CAM areas. Properties of bi-quadratic B-spline surface are investigated by the subdivision approach, and the control mesh of bi-quadratic B-spline surface is constructed by employing Doo-Sabin subdivision to derive the parametric representation of interpolation surface. For enhancing the efficiency of handling mesh with larger scale data, we first partition the mesh into a number of sub-meshes and compute their corresponding control nets satisfying interpolatory conditions, then the sub-nets are integrated to form a whole net such that its bi-quadratic B-spline surface interpolates all given vertices and normal vectors.%顶点位置插值是自由曲面造型的基本方法,法向插值在一些CAD/CAM系统中也有重要应用.文中利用子分曲面理论研究双二次B样条曲面的性质,在此基础上利用Doo-Sabin子分模式构造插值顶点位置和法向的双二次B样条曲面控制网格,得到插值曲面的参数表示.为了提高效率,对规模较大的网格数据,先把它划分成若干片子网格,分别求出满足与子网格相关的插值条件的控制网格. 最后再把它们整合在一起形成完整的控制网格,使得相应的二次B样条曲面插值所有顶点及法向.

  9. Dynamic divisive normalization predicts time-varying value coding in decision-related circuits.

    Science.gov (United States)

    Louie, Kenway; LoFaro, Thomas; Webb, Ryan; Glimcher, Paul W

    2014-11-26

    Normalization is a widespread neural computation, mediating divisive gain control in sensory processing and implementing a context-dependent value code in decision-related frontal and parietal cortices. Although decision-making is a dynamic process with complex temporal characteristics, most models of normalization are time-independent and little is known about the dynamic interaction of normalization and choice. Here, we show that a simple differential equation model of normalization explains the characteristic phasic-sustained pattern of cortical decision activity and predicts specific normalization dynamics: value coding during initial transients, time-varying value modulation, and delayed onset of contextual information. Empirically, we observe these predicted dynamics in saccade-related neurons in monkey lateral intraparietal cortex. Furthermore, such models naturally incorporate a time-weighted average of past activity, implementing an intrinsic reference-dependence in value coding. These results suggest that a single network mechanism can explain both transient and sustained decision activity, emphasizing the importance of a dynamic view of normalization in neural coding.

  10. Normal and retarded children's understanding of semantic relations in different verbal contexts.

    Science.gov (United States)

    Duchan, J F; Erickson, J G

    1976-12-01

    The effect of different semantic relations presented in different verbal contexts to language retarded and normal children at the one-and two-word stage of development was studied. No significant difference was found between the performance of mentally retarded language-disordered and normal children on the verbal comprehension task. Both groups of children performed best on the possessive, next on the agent-object, then actor-action, and poorest on the locative relations. Finally, nonsense, telegraphic, and expanded contexts did make a difference in the children's understandings with expanded being the best, telegraphic next, and nonsense contexts poorest. Theoretical and clinical implications are discussed.

  11. Classifying, archiving and digitalizing documents related to normal conducting magnets & preparing graphs of magnetic measurement results

    CERN Document Server

    Bayramoglu, Gultug

    2016-01-01

    The main project aims to classify and digitalize documents related to normal conducting magnets. These documents include magnetic measurement results and their graphs, inspection reports, manufacturing reports and so on. The archive of Normal Conducting Magnets Section consists lots of different types of normal conducting magnets documents. Besides these magnet varieties, there are still documents from the times of first accelerator at CERN. In that moment, my project involves to identify, classify and digitalize documents and make them ready to be uploaded in NORMA - database of normal conducting magnets. In addition part of my time I’ve spent on second project, which was preparing graphs of magnetic measurement results of magnets such as current and magnetic field. The aim of these graphs is to compare parameters of magnets the same type and check measurement results’ consistency according to reference points. All of these graphs are on time basis.

  12. Extending the Concepts of Normalization from Relational Databases to Extensible-Markup-Language Databases Model

    Directory of Open Access Journals (Sweden)

    H.J. F. El-Sofany

    2008-01-01

    Full Text Available In this study we have studied the problem of how to extend the concepts of Functional Dependency (FD and normalization in relational databases to include the eXtensible Markup Language (XML model. We shown that, like relational databases, XML documents may contain redundant information and this redundancy may cause update anomalies. Furthermore, such problems are caused by certain functional dependencies among paths in the document. Our goal is to find a way for converting an arbitrary XML Schema to a well-designed one, that avoids these problems. We introduced new definitions of FD and normal forms of XML Schema (X-1NF, X-2NF, X-3NF and X-BCNF. We shown that our normal forms are necessary and sufficient to ensure all conforming XML documents have no redundancies.

  13. Thermodynamic equilibrium in relativity: four-temperature, Killing vectors and Lie derivatives

    CERN Document Server

    Becattini, F

    2016-01-01

    The main concepts of general relativistic thermodynamics and general relativistic statistical mechanics are reviewed. The main building block of the proper relativistic extension of the classical thermodynamics laws is the four-temperature vector \\beta, which plays a major role in the quantum framework and defines a very convenient hydrodynamic frame. The general relativistic thermodynamic equilibrium condition demands \\beta to be a Killing vector field. We show that a remarkable consequence is that all Lie derivatives of all physical observables along the four-temperature flow must then vanish.

  14. NPS State Vector Analysis and Relative Motion Plotting Software for STS-51. Appendix C

    Science.gov (United States)

    1994-03-01

    vector *’tans -in, State -vector ftans-out, * double tans buf, int fbi, int point num, Perturbations *P) *This filter, created by Lou Zyla is designed to...main menu; ups menu displayWntO; return YES; static void ups display graphics(int graph mode) void upsdisplay~ grphics (int graph mode) if (nps ub~plot...in~graphics mode = YES; else if (ups graphics info.in graphics-mode = = NO) return; closegrapho; ups graphics info. in~ grphics mode =NO; void nps

  15. Moving Target Focusing with Normalized Relative Speed in Azimuth-Invarian Bistatic Sar

    OpenAIRE

    Vu, Viet Thuy; Sjögren, Thomas; Pettersson, Mats

    2013-01-01

    Focusing moving targets with Normalized Relative Speed (NRS) for bistatic synthetic aperture radar (SAR) is discussed in this paper. The discussion concentrates on azimuth invariant bistatic geometry. The focusing approach for azimuth-invariant bistatic geometry is derived analytically. The validity of the proposed approach for other bistatic geometry like azimuth-variant is also investigated.

  16. Using natural language processing to improve biomedical concept normalization and relation mining

    NARCIS (Netherlands)

    N. Kang (Ning)

    2013-01-01

    textabstractThis thesis concerns the use of natural language processing for improving biomedical concept normalization and relation mining. We begin with introducing the background of biomedical text mining, and subsequently we will continue by describing a typical text mining pipeline, some key

  17. Using natural language processing to improve biomedical concept normalization and relation mining

    NARCIS (Netherlands)

    N. Kang (Ning)

    2013-01-01

    textabstractThis thesis concerns the use of natural language processing for improving biomedical concept normalization and relation mining. We begin with introducing the background of biomedical text mining, and subsequently we will continue by describing a typical text mining pipeline, some key iss

  18. Articulated Entity Relationship (AER Diagram for Complete Automation of Relational Database Normalization

    Directory of Open Access Journals (Sweden)

    P. S. Dhabe

    2010-05-01

    Full Text Available In this paper an Articulated Entity Relationship (AER diagram is proposed, which is an extension of EntityRelationship (ER diagram to accommodate the Functional Dependency (FD information as its integral partfor complete automation of normalization. In current relational databases (RDBMS automation ofnormalization by top down approach is possible using ER diagram as an input, provided the FD informationis available independently, meanwhile, through user interaction. Such automation we call partial andconditional automation. To avoid this user interaction, there is a strong need to accommodate FDinformation as an element of ER diagram itself. Moreover, ER diagrams are not designed by taking intoaccount the requirements of normalization. However, for better automation of normalization it must be anintegral part of conceptual design (ER Diagram. The prime motivation behind this paper to design a systemthat need only proposed AER diagram as a sole input and normalize the database up to a given normal formin one go. This would allow more amount of automation than the current approach. Such automation we callas total and unconditional automation, which is better and complete in true sense. As the proposed AERdiagram is designed by taking in to account the normalization process, normalization up to Boyce CoddNormal Form (BCNF becomes an integral part of conceptual design. Additional advantage of AER diagramis that any modifications (addition, deletion or updation of attributes made to the AER diagram willautomatically be reflected in its FD information. Thus description of schema and FD information isguaranteed to be consistent. This cannot be assured in current approach using ER diagrams, as schema andFD information are provided to the system at two different times, separately.

  19. Surveillance study of vector species on board passenger ships, Risk factors related to infestations

    Directory of Open Access Journals (Sweden)

    Hatzoglou Chrissi

    2008-03-01

    Full Text Available Abstract Background Passenger ships provide conditions suitable for the survival and growth of pest populations. Arthropods and rodents can gain access directly from the ships' open spaces, can be carried in shiploads, or can be found on humans or animals as ectoparasites. Vectors on board ships may contaminate stored foods, transmit illness on board, or, introduce diseases in new areas. Pest species, ship areas facilitating infestations, and different risk factors related to infestations were identified in 21 ferries. Methods 486 traps for insects and rodents were placed in 21 ferries. Archives of Public Health Authorities were reviewed to identify complaints regarding the presence of pest species on board ferries from 1994 to 2004. A detail questionnaire was used to collect data on ship characteristics and pest control practices. Results Eighteen ferries were infested with flies (85.7%, 11 with cockroaches (52.3%, three with bedbugs, and one with fleas. Other species had been found on board were ants, spiders, butterflies, beetles, and a lizard. A total of 431 Blattella germanica species were captured in 28 (9.96% traps, and 84.2% of them were nymphs. One ship was highly infested. Cockroach infestation was negatively associated with ferries in which Hazard Analysis Critical Control Point system was applied to ensure food safety on board (Relative Risk, RR = 0.23, p = 0.03, and positively associated with ferries in which cockroaches were observed by crew (RR = 4.09, p = 0.007, no cockroach monitoring log was kept (RR = 5.00, p = 0.02, and pesticide sprays for domestic use were applied by crew (RR = 4.00, p = 0.05. Cockroach infested ships had higher age (p = 0.03. Neither rats nor mice were found on any ship, but three ferries had been infested with a rodent in the past. Conclusion Integrated pest control programs should include continuing monitoring for a variety of pest species in different ship locations; pest control measures should be more

  20. 18,000 displacement vectors and 44 positions surveys of RFID tracers show a normal diffusion of the bedload in a proglacial stream (Bossons glacier, France)

    Science.gov (United States)

    Guillon, Hervé; Mugnier, Jean-Louis; Buoncristiani, Jean-François

    2016-04-01

    Bedload transport is a stochastic process during which each particle hops for a random length then rests for a random duration. In recent years, this probabilistic approach was investigated by theoretical models, numerical simulations and laboratory experiments. These experiments are generally carried out on short time scales with sand, but underline the diffusive behaviour of the bedload. Conversely, marked pebbles in natural streams have mainly be used to infer about transport processes and transport time of the bedload. In this study, the stochastic characteristics of bedload transport are inferred from the radio-frequency identification (RFID) of pebbles. In particular, we provide insights for answering the following question : is the bedload transport sub-diffusive, normally diffusive or super-diffusive at the long time scale (i.e. global range)? Experiments designed to investigate the phenomenology of bedload transport have been carried out in the proglacial area of Bossons glacier. This 350 m long alluvial plain exhibits daily flood from the glacial system and is still redistributing material from catastrophic events pre-dating our investigations. From 2011 to 2014, the position of the ˜ 1000 RFID tracers have been measured by a mobile antenna and a differential GPS during 44 surveys providing ˜ 2500 tracer positions. Additionnaly, in 2014, 650 new tracers were seeded upstream from a static RFID antenna located at the outlet of the study area. For the 1 to 32 cm fraction surveyed, both mobile and static antenna results show no evidence for a significant export outside of the surveyed zone. Initial data have been maximized by using each possible campaign pairs leading to ˜700 campaign pairs and more than 18,000 displacement vectors. To our knowledge, this is one of the most extensive dataset of tracers positions measured in a natural stream using the RFID methodology. Using 152 campaigns pairs with at least 20 retrieved tracers,r standard probability

  1. Age-related contrast enhancement study of normal bone marrow in lumbar spinal MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young A; Ha, Doo Hoe [Pundang CHA General Hospital, Pochon CHA Univ. College of Medicine, Pochon (Korea, Republic of)

    1999-11-01

    The purpose of this study was to evaluate the degree of contrast enhancement of normal bone marrow in L-spine relating to aging and to determine the range of contrast enhancement in normal bone marrow. We analyzed a total of 120 patients (20 per decade) who had undergone lumbar spinal MRI and who ranged in age from the 2nd decade to more than the 7th. Bone marrow revealed no abnormal pathology. Sagittal T1-weighted spin echo sequences were obtained before and after gadolinium administration. For each sequence, a region of interest was drawn within the L1 vertebral body from the midsagittal slice. Signal intensity (SI) values of each sequence were ascertained and the percentage increase in SI was calculated. After contrast enhancement, lumbar MRI revealed no statistically significant in the percentage increase in SI of normal bone marrow in relation to aging. Most patients (99%) however showed an SI increase of between 10% and 49%. In only four, none of whom were aged over 40, was this increase above 50%. Lumbar MRI, revealed no statistically significant difference in percentage increase in SI in normal bone marrow relating to aging, but when the increase is above 50% in a patient aged over 40, bone marrow pathology should be further investigated.

  2. Sex-related differences in peripheral glucose metabolism in normal subjects.

    Science.gov (United States)

    Paula, F J; Pimenta, W P; Saad, M J; Paccola, G M; Piccinato, C E; Foss, M C

    1990-01-01

    The metabolic response of muscle tissue to glucose ingestion was studied in 10 normal men (M) and women (F) by using the forearm balance technique and indirect calorimetry simultaneously. During the 3 hours after a 75 g--oral glucose load, glucose uptake per unit muscle mass was significantly higher in women than in men, F = 187.3 +/- 26.9 vs M = 116.7 +/- 9.5 mg/100 g forearm muscle (P less than 0.05). A significant difference in muscle glucose fate was also observed since the amount of glucose utilized through a nonoxidative pathway was significantly higher in women, F = 84.5 +/- 2.6% (161.8 +/- 27.3 mg/100 g forearm muscle) vs M = 75.3 +/- 2.2% (87.2 +/- 8.6 mg/100 g forearm muscle) (P less than 0.05), whereas the amount of glucose oxidized in relation to glucose uptake was significantly higher in men, M = 24.7 +/- 2.2% (28.2 +/- 3.2 mg/100 g forearm muscle) vs F = 15.5 +/- 2.6% (27.8 +/- 5.4 mg/100 g forearm muscle) (P less than 0.05). No significant differences in insulin response to glucose ingestion were detected between groups. The women showed greater suppression of serum free fatty acids (FFA) levels in relation to basal levels than men. We conclude that: 1) after ingesting 75 g glucose, normal women showed greater glucose uptake per unit muscle mass than normal men, 2) for 3 hours after the ingestion of 75 g glucose, the predominant tendency toward utilizing glucose by a nonoxidative pathway is more marked in normal women than in normal men, and 3) the higher glucose uptake per unit muscle mass in the female group in the presence of an insulin response not significantly different from that of the male group suggests that muscle insulin sensitivity is greater in normal women.

  3. The simultaneous boost technique; The concept of relative normalized total dose

    Energy Technology Data Exchange (ETDEWEB)

    Lebesque, J.V.; Keus, R.B. (Nederlands Kanker Inst. ' Antoni van Leeuwenhoekhuis' , Amsterdam (Netherlands))

    1991-09-01

    Simultaneous boost technique in radiotherapy consists of delivering the boost treatment (additional doses to reduced volumes) simultaneously with the basic (large-field) treatment for all treatment sessions. Both the dose per fraction delivered by basic-treatment fields and by boost-treatment fields have to be reduced to end up with the same total dose in boost volume as in the original schedule, where basic treatment preceded boost treatment. These dose reductions and corresponding weighting factors have been calculated using the linear-quadratic (LQ) model and the concept of Normalized Total Dose (NTD). Relative NTD distributions were computed to evaluate the dose distributions resulting for the simultaneous boost technique with respect to acute and late normal tissue damage and tumor control. For the example of treatment of prostate cancer the weighting factors were calculated on basis of NTD for late normal tissue damage. For treatment of oropharyngeal cancer NTD for acute and normal tissue damage was used to determine the weighting factors. In this last example a theoretical sparing of late normal tissue damage can be demonstrated. Another advantage of simultaneous boost technique is that megavoltage images of the large basic-treatment fields facilitates the determination of the position of the patient with respect to the small boost-treatment fields. (author). 42 refs., 8 figs.

  4. Reciprocity relation for the vector radiative transport equation and its application to diffuse optical tomography with polarized light

    CERN Document Server

    Tricoli, Ugo; Da Silva, Anabela; Markel, Vadim A

    2016-01-01

    We derive a reciprocity relation for vector radiative transport equation (vRTE) that describes propagation of polarized light in multiple-scattering media. We then show how this result, together with translational invariance of a plane-parallel sample, can be used to compute efficiently the sensitivity kernel of diffuse optical tomography (DOT) by Monte Carlo simulations. Numerical examples of polarization-selective sensitivity kernels thus computed are given.

  5. Quantitative evaluation of myocardial function by a volume-normalized map generated from relative blood flow

    Energy Technology Data Exchange (ETDEWEB)

    Fukami, Tadanori [Department of Bio-system Engineering, Faculty of Engineering, Yamagata University, Yonezawa, Yamagata 992-8510 (Japan); Sato, Hidenori [Department of Bio-system Engineering, Faculty of Engineering, Yamagata University, Yonezawa, Yamagata 992-8510 (Japan); Wu, Jin [Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575 (Japan); Lwin, Thet-Thet- [Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575 (Japan); Yuasa, Tetsuya [Department of Bio-system Engineering, Faculty of Engineering, Yamagata University, Yonezawa, Yamagata 992-8510 (Japan); Kawano, Satoru [Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575 (Japan); Iida, Keiji [Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575 (Japan); Akatsuka, Takao [Department of Bio-system Engineering, Faculty of Engineering, Yamagata University, Yonezawa, Yamagata 992-8510 (Japan); Hontani, Hidekata [Department of Computer Science and Engineering, Nagoya Institute of Technology, Aichi 466-8555 (Japan); Takeda, Tohoru [Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575 (Japan); Tamura, Masao [Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575 (Japan); Yokota, Hiroshi [Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki 305-8575 (Japan)

    2007-07-21

    Our study aimed to quantitatively evaluate blood flow in the left ventricle (LV) of apical hypertrophic cardiomyopathy (APH) by combining wall thickness obtained from cardiac magnetic resonance imaging (MRI) and myocardial perfusion from single-photon emission computed tomography (SPECT). In this study, we considered paired MRI and myocardial perfusion SPECT from ten patients with APH and ten normals. Myocardial walls were detected using a level set method, and blood flow per unit myocardial volume was calculated using 3D surface-based registration between the MRI and SPECT images. We defined relative blood flow based on the maximum in the whole myocardial region. Accuracies of wall detection and registration were around 2.50 mm and 2.95 mm, respectively. We finally created a bull's-eye map to evaluate wall thickness, blood flow (cardiac perfusion) and blood flow per unit myocardial volume. In patients with APH, their wall thicknesses were over 10 mm. Decreased blood flow per unit myocardial volume was detected in the cardiac apex by calculation using wall thickness from MRI and blood flow from SPECT. The relative unit blood flow of the APH group was 1/7 times that of the normals in the apex. This normalization by myocardial volume distinguishes cases of APH whose SPECT images resemble the distributions of normal cases.

  6. Relation of Reproductive Factors and Heel Quantitative Ultrasound Parameters in Normal Women of Tehran

    Directory of Open Access Journals (Sweden)

    B Larijani

    2004-03-01

    Full Text Available Quantitative Ultrasound (QUS is a noninvasive, inexpensive and portable method for bone densitometry. It may measure some other parameters in addition to BMD, like elasticity and micro architecture. This study designed to determine the relation between reproductive factors and calcaneus QUS parameters in normal women of Tehran. BMD of heel in 151 normal women, 20-72Y/O (participator of Iranian Multi center Osteoporosis Study was assessed using Achilles+ (GE, Lunar Corporation, USA. After assessment of normal values, Stiffness Index percentiles acquired. With consideration of correlation between variables, multiple regression analysis was used. Mean±SD values of Speed of Sound (SOS, Broad Band Ultrasound Attenuation (BUA and Stiffness Index (SI, was 36/751527/25, 121/4215/1, 94/4617/92, respectively. Parameters decreased with age (P<0/01. Years of menopause significantly related with QUS parameters and age of menopause significant related with SOS and SI. Results show effectiveness of some reproductive factors on QUS parameters.

  7. The effect of normal aging and age-related macular degeneration on perceptual learning.

    Science.gov (United States)

    Astle, Andrew T; Blighe, Alan J; Webb, Ben S; McGraw, Paul V

    2015-01-01

    We investigated whether perceptual learning could be used to improve peripheral word identification speed. The relationship between the magnitude of learning and age was established in normal participants to determine whether perceptual learning effects are age invariant. We then investigated whether training could lead to improvements in patients with age-related macular degeneration (AMD). Twenty-eight participants with normal vision and five participants with AMD trained on a word identification task. They were required to identify three-letter words, presented 10° from fixation. To standardize crowding across each of the letters that made up the word, words were flanked laterally by randomly chosen letters. Word identification performance was measured psychophysically using a staircase procedure. Significant improvements in peripheral word identification speed were demonstrated following training (71% ± 18%). Initial task performance was correlated with age, with older participants having poorer performance. However, older adults learned more rapidly such that, following training, they reached the same level of performance as their younger counterparts. As a function of number of trials completed, patients with AMD learned at an equivalent rate as age-matched participants with normal vision. Improvements in word identification speed were maintained at least 6 months after training. We have demonstrated that temporal aspects of word recognition can be improved in peripheral vision with training across a range of ages and these learned improvements are relatively enduring. However, training targeted at other bottlenecks to peripheral reading ability, such as visual crowding, may need to be incorporated to optimize this approach.

  8. Relation of distortion product otoacoustic emission and tinnitus in normal hearing patients: A pilot study

    Directory of Open Access Journals (Sweden)

    Datt Modh

    2014-01-01

    Full Text Available Introduction: Tinnitus, the perception of the sound in the absence of an external acoustic source, disrupts the daily life 1 out of every 200 adults, yet its physiological basis remains largely a mystery. The generation of tinnitus is commonly linked with the impaired functioning of the outer hair cells (OHC inside the cochlea. Otoacoustic emissions are the objective test used to assess their activity. Objective: The objective of the investigation was to study the features of Distortion product OtoAcoustic emissions (DPOAE in a group of tinnitus patients with normal hearing and to find out whether there is any difference in DPOAE findings in the tinnitus patients with normal hearing and in persons with normal hearing with no complaint of tinnitus. Materials and Methods: The participants consisted of two groups. The subject group consisted of 16 ears of patients, in which 6 subjects were having tinnitus in both ears while 4 subjects were having tinnitus only in one ear. All subjects were aged between 20 to 60 years with complaint of tinnitus with audiometrically normal hearing. Control group was comprised of 16 audiometrically normal hearing ears of persons who were age and gender matched with the subject groups and had no complaint of tinnitus. Both the subject group as well as control group was subjected for DPOAE test. Findings of both the groups were compared using the unpaired t test. Result and conclusion: It was observed that the amplitudes of DPOAE were significantly lower in tinnitus patients than that of persons without complaint of tinnitus, at a frequency of 1281-1560, 5120-6250, 7243-8837 Hz, which imply that decrease of DPOAEs amplitudes may be related to the presence of tinnitus. It can be concluded that there is association between tinnitus and reduced OHC activity which indicate the OHC of cochlea are involved in the generation of tinnitus.

  9. Mechanical properties of the normal human cartilage-bone complex in relation to age

    DEFF Research Database (Denmark)

    Ding, Ming; Dalstra, M; Linde, F

    1998-01-01

    OBJECTIVE: This study investigates the age-related variations in the mechanical properties of the normal human tibial cartilage-bone complex and the relationships between cartilage and bone. DESIGN: A novel technique was applied to assess the mechanical properties of the cartilage and bone by means...... normal donors aged 16-83 years were tested in compression. The deformation was measured simultaneously in bone and cartilage to obtain the mechanical properties of both tissues. RESULTS: The stiffnesses and elastic energies of both cartilage and bone showed an initial increase, with maxima at 40 years......, followed by a steady decline. The viscoelastic energy was maximal at younger ages (16-29 years), followed by a steady decline. The energy absorption capacity did not vary with age. Stiffnesses and elastic energies were correlated significantly between cartilage and bone. CONCLUSIONS: The present study...

  10. Role Bending: Complex Relationships Between Viruses, Hosts, and Vectors Related to Citrus Leprosis, an Emerging Disease.

    Science.gov (United States)

    Roy, Avijit; Hartung, John S; Schneider, William L; Shao, Jonathan; Leon, Guillermo; Melzer, Michael J; Beard, Jennifer J; Otero-Colina, Gabriel; Bauchan, Gary R; Ochoa, Ronald; Brlansky, Ronald H

    2015-07-01

    Citrus leprosis complex is an emerging disease in the Americas, associated with two unrelated taxa of viruses distributed in South, Central, and North America. The cytoplasmic viruses are Citrus leprosis virus C (CiLV-C), Citrus leprosis virus C2 (CiLV-C2), and Hibiscus green spot virus 2, and the nuclear viruses are Citrus leprosis virus N (CiLV-N) and Citrus necrotic spot virus. These viruses cause local lesion infections in all known hosts, with no natural systemic host identified to date. All leprosis viruses were believed to be transmitted by one species of mite, Brevipalpus phoenicis. However, mites collected from CiLV-C and CiLV-N infected citrus groves in Mexico were identified as B. yothersi and B. californicus sensu lato, respectively, and only B. yothersi was detected from CiLV-C2 and CiLV-N mixed infections in the Orinoco regions of Colombia. Phylogenetic analysis of the helicase, RNA-dependent RNA polymerase 2 domains and p24 gene amino acid sequences of cytoplasmic leprosis viruses showed a close relationship with recently deposited mosquito-borne negevirus sequences. Here, we present evidence that both cytoplasmic and nuclear viruses seem to replicate in viruliferous Brevipalpus species. The possible replication in the mite vector and the close relationship with mosquito borne negeviruses are consistent with the concept that members of the genus Cilevirus and Higrevirus originated in mites and citrus may play the role of mite virus vector.

  11. Differential expression profiling between the relative normal and dystrophic muscle tissues from the same LGMD patient

    Directory of Open Access Journals (Sweden)

    Yang Wei

    2006-12-01

    Full Text Available Abstract Background Limb-girdle muscular dystrophy (LGMD is a group of heterogeneous muscular disorders with autosomal dominant and recessive inheritance, in which the pelvic or shoulder girdle musculature is predominantly or primarily involved. Although analysis of the defective proteins has shed some light onto their functions implicated in the etiology of LGMD, our understanding of the molecular mechanisms underlying muscular dystrophy remains incomplete. Methods To give insight into the molecular mechanisms of AR-LGMD, we have examined the differentially expressed gene profiling between the relative normal and pathological skeletal muscles from the same AR-LGMD patient with the differential display RT-PCR approach. The research subjects came from a Chinese AR-LGMD family with three affected sisters. Results In this report, we have identified 31 known genes and 12 unknown ESTs, which were differentially expressed between the relative normal and dystrophic muscle from the same LGMD patient. The expression of many genes encoding structural proteins of skeletal muscle fibers (such as titin, myosin heavy and light chains, and nebulin were dramatically down-regulated in dystrophic muscles compared to the relative normal muscles. The genes, reticulocalbin 1, kinectin 1, fatty acid desaturase 1, insulin-like growth factor binding protein 5 (IGFBP5, Nedd4 family interacting protein 1 (NDFIP1, SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, encoding the proteins involved in signal transduction and gene expression regulation were up-regulated in the dystrophic muscles. Conclusion The functional analysis of these expression-altered genes in the pathogenesis of LGMD could provide additional information for understanding possible molecular mechanisms of LGMD development.

  12. Identification of Gender-Related Normality Regions for T-Wave Alternans

    Science.gov (United States)

    Burattini, Laura; Zareba, Wojciech; Burattini, Roberto

    2011-01-01

    Background T-wave alternans (TWA), a harbinger of sudden cardiac death, associates to a broad variety of pathologies. In a previous study, we observed the presence of unstable and low-amplitude TWA also in healthy subjects, and considered it as “physiological TWA.” The possible existence of different TWA characteristics between males and female is investigated in the present work. Methods Resting ECG recordings from 142 control healthy subjects, 77 males and 65 females, were submitted to our adaptive match filter (AMF) based method for TWA detection and characterization in terms of duration, amplitude, and their product. The 99.5th percentile of these parameters distributions over the entire control population and over the male and female subgroups, were used to define thresholds which delimit a gender-independent and male- and female-related TWA normality regions, respectively, out of which abnormal TWA cases (TWA+) are expected to fall. Clinical usefulness of these regions was tested using a population of 151 coronary artery disease (CAD) patients, divided into 128 males and 23 females. Results In our control-female population, TWA duration was significantly longer than in control-male population (65 ± 13 beat vs 52 ± 14 beat; P < 10−6). Our gender-related normality regions allowed identification of 36 (23.8%) TWA+ cases among the CAD patients, 17 more than those obtained from a gender-independent region. All these 17 patients were CAD males with over-threshold TWA duration. Conclusions TWA is a gender-related phenomenon. Definition of gender-related TWA normality regions improves identification of patients at increased TWA stability (i.e., prolonged TWA duration) and, thus, at increased risk of arrhythmic events. PMID:20946555

  13. Introducing Vectors.

    Science.gov (United States)

    Roche, John

    1997-01-01

    Suggests an approach to teaching vectors that promotes active learning through challenging questions addressed to the class, as opposed to subtle explanations. Promotes introducing vector graphics with concrete examples, beginning with an explanation of the displacement vector. Also discusses artificial vectors, vector algebra, and unit vectors.…

  14. Isotropic periodic sum for multipole interactions and a vector relation for calculation of the Cartesian multipole tensor

    Science.gov (United States)

    Wu, Xiongwu; Pickard, Frank C.; Brooks, Bernard R.

    2016-10-01

    Isotropic periodic sum (IPS) is a method to calculate long-range interactions based on the homogeneity of simulation systems. By using the isotropic periodic images of a local region to represent remote structures, long-range interactions become a function of the local conformation. This function is called the IPS potential; it folds long-ranged interactions into a short-ranged potential and can be calculated as efficiently as a cutoff method. It has been demonstrated that the IPS method produces consistent simulation results, including free energies, as the particle mesh Ewald (PME) method. By introducing the multipole homogeneous background approximation, this work derives multipole IPS potentials, abbreviated as IPSMm, with m being the maximum order of multipole interactions. To efficiently calculate the multipole interactions in Cartesian space, we propose a vector relation that calculates a multipole tensor as a dot product of a radial potential vector and a directional vector. Using model systems with charges, dipoles, and/or quadrupoles, with and without polarizability, we demonstrate that multipole interactions of order m can be described accurately with the multipole IPS potential of order 2 or m - 1, whichever is higher. Through simulations with the multipole IPS potentials, we examined energetic, structural, and dynamic properties of the model systems and demonstrated that the multipole IPS potentials produce very similar results as PME with a local region radius (cutoff distance) as small as 6 Å.

  15. Event-related functional magnetic resonance imaging changes during relational retrieval in normal aging and amnestic mild cognitive impairment.

    Science.gov (United States)

    Giovanello, Kelly S; De Brigard, Felipe; Hennessey Ford, Jaclyn; Kaufer, Daniel I; Burke, James R; Browndyke, Jeffrey N; Welsh-Bohmer, Kathleen A

    2012-09-01

    The earliest cognitive deficits observed in amnestic mild cognitive impairment (aMCI) appear to center on memory tasks that require relational memory (RM), the ability to link or integrate unrelated pieces of information. RM impairments in aMCI likely reflect neural changes in the medial temporal lobe (MTL) and posterior parietal cortex (PPC). We tested the hypothesis that individuals with aMCI, as compared to cognitively normal (CN) controls, would recruit neural regions outside of the MTL and PPC to support relational memory. To this end, we directly compared the neural underpinnings of successful relational retrieval in aMCI and CN groups, using event-related functional magnetic resonance imaging (fMRI), holding constant the stimuli and encoding task. The fMRI data showed that the CN, compared to the aMCI, group activated left precuneus, left angular gyrus, right posterior cingulate, and right parahippocampal cortex during relational retrieval, while the aMCI group, relative to the CN group, activated superior temporal gyrus and supramarginal gyrus for this comparison. Such findings indicate an early shift in the functional neural architecture of relational retrieval in aMCI, and may prove useful in future studies aimed at capitalizing on functionally intact neural regions as targets for treatment and slowing of the disease course. (JINS, 2012, 18, 1-12).

  16. Age-related changes in normal adult pancreas: MR imaging evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Tomohiro, E-mail: tomohiro@med.kawasaki-m.ac.jp [Department of Radiology, Kawasaki Medical School, Matsushima, Kurashiki City, Okayama, 701-0192 (Japan); Ito, Katsuyoshi, E-mail: itokatsu@med.kawasaki-m.ac.jp [Department of Radiology, Kawasaki Medical School, Matsushima, Kurashiki City, Okayama, 701-0192 (Japan); Tamada, Tsutomu, E-mail: ttamada@med.kawasaki-m.ac.jp [Department of Radiology, Kawasaki Medical School, Matsushima, Kurashiki City, Okayama, 701-0192 (Japan); Sone, Teruki, E-mail: tsone@med.kawasaki-m.ac.jp [Department of Radiology, Kawasaki Medical School, Matsushima, Kurashiki City, Okayama, 701-0192 (Japan); Noda, Yasufumi, E-mail: yasufumi@med.kawasaki-m.ac.jp [Department of Radiology, Kawasaki Medical School, Matsushima, Kurashiki City, Okayama, 701-0192 (Japan); Higaki, Atsushi, E-mail: ahah@med.kawasaki-m.ac.jp [Department of Radiology, Kawasaki Medical School, Matsushima, Kurashiki City, Okayama, 701-0192 (Japan); Kanki, Akihiko, E-mail: ponbon@med.kawasaki-m.ac.jp [Department of Radiology, Kawasaki Medical School, Matsushima, Kurashiki City, Okayama, 701-0192 (Japan); Tanimoto, Daigo, E-mail: daigoro@med.kawasaki-m.ac.jp [Department of Radiology, Kawasaki Medical School, Matsushima, Kurashiki City, Okayama, 701-0192 (Japan); Higashi, Hiroki, E-mail: higahiro@med.kawasaki-m.ac.jp [Department of Radiology, Kawasaki Medical School, Matsushima, Kurashiki City, Okayama, 701-0192 (Japan)

    2012-09-15

    Objective: To investigate age-related changes in normal adult pancreas as identified by magnetic resonance imaging (MRI). Materials and methods: We examined 115 patients without pancreatic diseases (21–90 years) who underwent upper abdominal MRI to evaluate the normal pancreatic MRI findings related to aging. The parameters examined were the pancreatic anteroposterior (AP) diameter, pancreatic lobulation, pancreatic signal intensity (SI), depiction of the main pancreatic duct (MPD), grade of the visual SI decrease on the opposed-phase T1-weighted images compared with in-phase images, and enhancement effect of the pancreas in the arterial phase of dynamic imaging. Results: The pancreatic AP diameter significantly reduced (head, p = 0.0172; body, p = 0.0007; tail, p < 0.0001), and lobulation (p < 0.0001) and parenchymal fatty change (p < 0.0001) became more evident with aging. No significant correlation was observed between aging and pancreatic SI, however the SI on the in-phase T1-weighted images tended to decrease with aging. No significant correlation was observed between aging and the depiction of the MPD as well as aging and contrast enhancement. Conclusion: MRI findings of pancreatic atrophy, lobulation, and fatty degeneration are characteristic changes related to aging, and it is necessary to recognize these changes in the interpretation of abdominal MRI in patients with and without pancreatic disease.

  17. ON VECTOR NETWORK EQUILIBRIUM PROBLEMS

    Institute of Scientific and Technical Information of China (English)

    Guangya CHEN

    2005-01-01

    In this paper we define a concept of weak equilibrium for vector network equilibrium problems.We obtain sufficient conditions of weak equilibrium points and establish relation with vector network equilibrium problems and vector variational inequalities.

  18. Risk estimation based on mixed normal distribution model for diabetes-related hospitalization claims

    Institute of Scientific and Technical Information of China (English)

    WANG Xin-wang; WANG Juan; FANG Ji-qian

    2006-01-01

    @@ Medical insurance service, the important part of national healthcare supporting system with a history dating back more than 100 years ago,remains a global challenge because of its high rates of compensation and difficulty in risk control. When developing the diabetes related, hospitalization insurance, we found that the risk loss of the diabetic inpatients does not follow a symmetrical unimodal distribution: in fact, it is hard to describe its risk loses distribution with a single probability distribution model. Therefore, we put forward a risk measurement method based on a mixed normal distributions model for medical insurance of inpatients with diabetes.

  19. Normal viscous force of pendular liquid bridge between two relatively moving particles.

    Science.gov (United States)

    Washino, Kimiaki; Chan, Ei L; Matsumoto, Taku; Hashino, Seiji; Tsuji, Takuya; Tanaka, Toshitsugu

    2017-05-15

    In this work, Direct Numerical Simulations (DNS) of a pendular liquid bridge formed between two relatively moving particles are performed to evaluate the normal component of the viscous force exerted on the particles. The viscous force obtained are non-dimensionalised in order to clarify the parameters which can affect the dimensionless force. The DNS results are compared with the viscous force models in literature which are commonly used in DEM simulations. It is found that these models cannot be used with large inter-particle separation distance. A new and more accurate viscous force model is proposed from the DNS results which can be directly implemented in the DEM framework.

  20. Vector flow imaging of the ascending aorta. Are systolic backflow and atherosclerosis related?

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Lindskov; Møller-Sørensen, Hasse; Kjaergaard, Jesper

    2015-01-01

    In the ascending aorta, atherosclerotic plaque formation, which is a risk factor for cerebrovascular events, most often occurs along the inner curvature. Atherosclerosis is a multifactorial disease, but the predilection site for the aortic vessel degradation is probably flow dependent. To better...... understand the aortic flow and especially the complex flow patterns, the ascending aorta was scanned intraoperatively in patients undergoing heart surgery using the angle-independent vector velocity ultrasound method Transverse Oscillation (TO). The primary aim of the study was to analyze systolic backflow...... on the ascending aorta in long axis view. The presence of systolic backflow, visualized with TO, was correlated to aortic atherosclerosis, to systolic velocities obtained with transesophageal echocardiography and cardiac output obtained with pulmonary artery catheter thermodilution, to gender, age, aortic diameter...

  1. Relative abundance ofPhlebotominae sandflies with emphasis on vectors of kala-azar

    Institute of Scientific and Technical Information of China (English)

    Naveen Samuel Singh; Doris Phillips-Singh

    2010-01-01

    Objective:To identify potential vectors of kala-azar from Northern plains of Uttar Pradesh, India.Methods:The collections were made using sticky paper traps, CDC light-traps, and aspirators from outdoors as well as indoors. All female sandflies were dissected and identified. Results:During January 2009 to July 2009, 528 phlebotomine specimens were collected including 329 males (62.3%) and 199 females (37.7%), approximately 238 (45%) of them were captured from indoor and 290 (55%) from outdoor resting places. Five species belonging to the genera Phlebotomus (8%) andSergentomyia (92%) were recorded.Conclusions:Public health measures such as case detection and treatment, the control of sandflies, the conjunction elimination of infected stray dogs and health education can be effective in controlling the disease.

  2. RELATIONS BETWEEN RUSSIA AND CHINA AS PART OF THE ASIAN VECTOR OF RUSSIAN DIPLOMACY (1990–2015

    Directory of Open Access Journals (Sweden)

    Alexei D. Voskresenski

    2015-01-01

    Full Text Available The article addresses to the Asian vector of the Russian foreign policy in particularly relations between Russia and China since post-Soviet period until nowdays. The author examines the stages of changing the Russian foreign policy as well as the positions of lobby parties in foreign policy. The article gives the detailed analysis of the cooperation between Russia and China in the Shanghai Cooperation Organization and BRICS. The author examines Russian-Chinese relations in key areas of collaboration such as mutual trade, nuclear power and military-technical sphere. According to the author significant step in Russian-Chinese relations is the Treaty of Good-Neighborliness and Friendly Cooperation signed in the July of 2001 during the visit of Jiang Zemin. The author assesses results of three stages of the relations between Russia and China and future development trends.

  3. Normal aging alters learning and attention-related teaching signals in basolateral amygdala.

    Science.gov (United States)

    Roesch, Matthew R; Esber, Guillem R; Bryden, Daniel W; Cerri, Domenic H; Haney, Zachary R; Schoenbaum, Geoffrey

    2012-09-19

    Normal aging has been associated with an increased propensity to wait for rewards. When this is tested experimentally, rewards are typically offered at increasing delays. In this setting, persistent responding for delayed rewards in aged rats could reflect either changes in the evaluation of delayed rewards or diminished learning, perhaps due to the loss of subcortical teaching signals induced by changes in reward; the loss or diminution of such teaching signals would result in slower learning with progressive delay of reward, which would appear as persistent responding. Such teaching signals have commonly been reported in phasic firing of midbrain dopamine neurons; however, similar signals have also been found in reward-responsive neurons in the basolateral amygdala (ABL). Unlike dopaminergic teaching signals, those in ABL seem to reflect surprise, increasing when reward is either better or worse than expected. Accordingly, activity is correlated with attentional responses and with the speed of learning after surprising increases or decreases in reward. Here we examined whether these attention-related teaching signals might be altered in normal aging. Young (3-6 months) and aged (22-26 months) male Long-Evans rats were trained on a discounting task used previously to demonstrate these signals. As expected, aged rats were less sensitive to delays, and this change was associated with a loss of attentional changes in orienting behavior and neural activity. These results indicate that normal aging alters teaching signals in the ABL. Changes in these teaching signals may contribute to a host of age-related cognitive changes.

  4. The effect of normal aging and age-related macular degeneration on perceptual learning

    Science.gov (United States)

    Astle, Andrew T.; Blighe, Alan J.; Webb, Ben S.; McGraw, Paul V.

    2015-01-01

    We investigated whether perceptual learning could be used to improve peripheral word identification speed. The relationship between the magnitude of learning and age was established in normal participants to determine whether perceptual learning effects are age invariant. We then investigated whether training could lead to improvements in patients with age-related macular degeneration (AMD). Twenty-eight participants with normal vision and five participants with AMD trained on a word identification task. They were required to identify three-letter words, presented 10° from fixation. To standardize crowding across each of the letters that made up the word, words were flanked laterally by randomly chosen letters. Word identification performance was measured psychophysically using a staircase procedure. Significant improvements in peripheral word identification speed were demonstrated following training (71% ± 18%). Initial task performance was correlated with age, with older participants having poorer performance. However, older adults learned more rapidly such that, following training, they reached the same level of performance as their younger counterparts. As a function of number of trials completed, patients with AMD learned at an equivalent rate as age-matched participants with normal vision. Improvements in word identification speed were maintained at least 6 months after training. We have demonstrated that temporal aspects of word recognition can be improved in peripheral vision with training across a range of ages and these learned improvements are relatively enduring. However, training targeted at other bottlenecks to peripheral reading ability, such as visual crowding, may need to be incorporated to optimize this approach. PMID:26605694

  5. Normal morphology of sacroiliac joints in children: magnetic resonance studies related to age and sex

    Energy Technology Data Exchange (ETDEWEB)

    Bollow, M.; Paris, S.; Mutze, S.; Hamm, B. [Institut fuer Roentgendiagnostik, Charite, Humboldt-Universitaet zu Berlin, Schumannstrasse 20-21, D-10098 Berlin (Germany); Braun, J.; Kannenberg, J. [Department of General Internal Medicine and Rheumatology, Klinikum Benjamin Franklin, Freie Universitaet Berlin, Berlin (Germany); Biedermann, T.; Schauer-Petrowskaja, C. [Department of Juvenile Rheumatology, II. Kinderklinik, Krankenhaus Berlin Buch, Berlin (Germany)

    1997-12-01

    Objective. To determine in a prospective study the normal MRI morphology of the sacroiliac joints (SIJs) in relation to age and sex during adolescence. Design and patients. A total of 98 children (63 boys, mean age 12.7{+-}2.8 years; 35 girls, mean age 13.7{+-}2.3 years), ranging in age from 8 to 17 years, with juvenile chronic arthritis (JCA) but without signs of sacroiliitis fulfilled the study prerequisites (no back pain and no pathologic changes of the SIJs on physical examination before MRI in a 1.5-year follow-up). An additional eight HLA-B27-negative boys and eight HLA-B27-negative girls without arthritis served as controls. The MRI protocol comprised a T1-weighted SE sequence, an opposed-phase T2*-weighted GE sequence, and a dynamic contrast-enhanced study in single-section technique. Results. Noncontrast MRI permitted differentiation of ``open`` from ossified segmental and lateral apophyses of the sacral wings, with a significant difference in age (P <0.05) between children with open and ossified apophyses. Ossification of the apophyses of the sacral wings was seen significantly earlier (P <0.05) in girls than in boys. Girls also had a significantly higher incidence of transitional lumbosacral vertebrae, pelvic asymmetries, and accessory joints. In the contrast-enhanced opposed-phase MRI study, normal cartilage of the SIJs showed no contrast enhancement whereas the joint capsule showed a moderate enhancement. Conclusion. There are significant age- and sex-related differences in the normal MRI morphology of juvenile SIJs. Our findings might serve as a standard of comparison for the evaluation of pathologic changes - in particular for the early identification of juvenile sacroiliitis. (orig.) With 10 figs., 30 refs.

  6. Neural correlates to food-related behavior in normal-weight and overweight/obese participants.

    Directory of Open Access Journals (Sweden)

    Alan Ho

    Full Text Available Two thirds of US adults are either obese or overweight and this rate is rising. Although the etiology of obesity is not yet fully understood, neuroimaging studies have demonstrated that the central nervous system has a principal role in regulating eating behavior. In this study, functional magnetic resonance imaging and survey data were evaluated for correlations between food-related problem behaviors and the neural regions underlying responses to visual food cues before and after eating in normal-weight individuals and overweight/obese individuals. In normal-weight individuals, activity in the left amygdala in response to high-calorie food vs. nonfood object cues was positively correlated with impaired satiety scores during fasting, suggesting that those with impaired satiety scores may have an abnormal anticipatory reward response. In overweight/obese individuals, activity in the dorsolateral prefrontal cortex (DLPFC in response to low-calorie food cues was negatively correlated with impaired satiety during fasting, suggesting that individuals scoring lower in satiety impairment were more likely to activate the DLPFC inhibitory system. After eating, activity in both the putamen and the amygdala was positively correlated with impaired satiety scores among obese/overweight participants. While these individuals may volitionally suggest they are full, their functional response to food cues suggests food continues to be salient. These findings suggest brain regions involved in the evaluation of visual food cues may be mediated by satiety-related problems, dependent on calorie content, state of satiation, and body mass index.

  7. Apoptosis-related genes control autophagy and influence DENV-2 infection in the mosquito vector, Aedes aegypti.

    Science.gov (United States)

    Eng, Matthew W; van Zuylen, Madeleine N; Severson, David W

    2016-09-01

    The mosquito Aedes aegypti is the primary urban vector for dengue virus (DENV) worldwide. Insight into interactions occurring between host and pathogen is important in understanding what factors contribute to vector competence. However, many of the molecular mechanisms for vector competence remain unknown. Our previous global transcriptional analysis suggested that differential expression of apoptotic proteins is involved in determining refractoriness vs susceptibility to DENV-2 infection in Ae. aegypti females following a DENV-infected blood meal. To determine whether DENV-refractory Ae. aegypti showed more robust apoptosis upon infection, we compared numbers of apoptotic cells from midguts of refractory and susceptible strains and observed increased numbers of apoptotic cells in only the refractory strain upon DENV-2 infection. Thereafter, we manipulated apoptosis through dsRNA interference of the initiator caspase, Aedronc. Unexpectedly, dsAedronc-treated females showed both decreased frequency of disseminated infection and decreased virus titer in infected individuals. Insect caspases have also previously been identified as regulators of the cellular recycling process known as autophagy. We observed activation of autophagy in midgut and fat body tissues following a blood meal, as well as programmed activation of several apoptosis-related genes, including the effector caspase, Casps7. To determine whether autophagy was affected by caspase knockdown, we silenced Aedronc and Casps7, and observed reduced activation of autophagy upon silencing. Our results provide evidence that apoptosis-related genes are also involved in regulating autophagy, and that Aedronc may play an important role in DENV-2 infection success in Ae. aegypti, possibly through its regulation of autophagy. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Age-related changes of task-specific brain activity in normal aging.

    Science.gov (United States)

    Ho, Ming-Chung; Chou, Chia-Yi; Huang, Chin-Fei; Lin, Yu-Te; Shih, Ching-Sen; Han, Shiang-Yi; Shen, Ming-Hsun; Chen, Tsung-Ching; Liang, Chi-lin; Lu, Ming-Chi; Liu, Chia-Ju

    2012-01-17

    An important question in healthcare for older patients is whether age-related changes in cortical reorganization can be measured with advancing age. This study investigated the factors behind such age-related changes, using time-frequency analysis of event-related potentials (ERPs). We hypothesized that brain rhythms was affected by age-related changes, which could be reflected in the ERP indices. An oddball task was conducted in two experimental groups, namely young participants (N=15; mean age 23.7±2.8 years) and older participants (N=15; mean age 70.1±7.9 years). Two types of stimuli were used: the target (1 kHz frequency) and standard (2 kHz frequency). We scrutinized three ERP indices: event-related spectral power (ERPSP), inter-trial phase-locking (ITPL), and event-related cross-phase coherence (ERPCOH). Both groups performed equally well for correct response rate. However, the results revealed a statistically significant age difference for inter-trial comparison. Compared with the young, the older participants showed the following age-related changes: (a) power activity decreased; however, an increase was found only in the late (P3, 280-450 ms) theta (4-7 Hz) component over the bilateral frontal and temporo-frontal areas; (b) low phase-locking in the early (N1, 80-140 ms) theta band over the parietal/frontal (right) regions appeared; (c) the functional connections decreased in the alpha (7-13 Hz) and beta (13-30 Hz) bands, but no difference emerged in the theta band between the two groups. These results indicate that age-related changes in task-specific brain activity for a normal aging population can be depicted using the three ERP indices.

  9. Application of bioelectrical impedance vector analysis (BIVA in dogs: a preliminary study on gender-related differences

    Directory of Open Access Journals (Sweden)

    Rebecca Ricci

    2010-01-01

    Full Text Available In this preliminary study, BIVA has been performed on 17 healthy Italian Hound dogs, 10 males (M and 7 females (F, in order to verify if gender-related differences can be detected. Only in F higher reactance (Xc values (F: 46.4 vs M: 37.7, P<0.05 and a significant negative correlation (-0.80, P<0.05 between BCS and resistance (R values were detected. 50%, 75% and 95% tolerance ellipses were calculated both in M and F using average Xc and R values standardized for withers height. Probably due to the low number of subjects used in the present study, the variability of the individual vector distribution (F: 79.6 vs M: 53.0Ohm/m, as well as the mean impedance vector lengtht (F: 548.2 vs M: 498.9Ohm/m, were similar in F and M. The gender-related difference in phase angle values was not significant (F: 0.168 vs M: 0.157, P=ns. In conclusion, the use of BIVA in dogs indicated differences between males and females which should be confirmed by a larger number of subjects.

  10. Relative length of human kidney as more precise measuring of normal kidney

    Directory of Open Access Journals (Sweden)

    Ilić Goran

    2010-01-01

    Full Text Available Introduction. Malformations in kidney development and kidney diseases are accompanied with changes in their size. For kidney evaluation in clinical practice, the kidney length is the most widely used measurement, since it provides the most precise results and it is easy to perform. Recently, the measurement of relative renal length has become more preferable as it takes into account the body height. The aim of this study was to measure both the absolute and relative length of normal cadaveric kidneys according to the body height, sex and age. Material and methods. In this study, we examined 95 adult cadaveric kidneys, without renal and vascular impairment, their age ranging from 23-87 years. To determine the period of the most abundant changes in kidney length, we separated them into a 10-year range. The relative renal length was calculated using the kidney length anybody height ratio (kidney/body ratio. Results. The absolute and relative length of left kidney in males was longer than the right one, with a statistically significant correlation. In females, the left kidney length was also longer than the right one, however, without a statistical significance. In contrast to the absolute length, the relative length of both kidneys did not show a significant difference between sexes, and did not manifest a significant decrease with age. There was a significant correlation between the kidney length and the subject’s height. Conclusion. The relative renal length represents kidney size better than the absolute renal length because it eliminates sex and height differences until the age of 59 year. From the seventh decade of life, there is a significant decrease in both the absolute and relative renal length.

  11. Vector velocimeter

    DEFF Research Database (Denmark)

    2012-01-01

    for generation of a reference beam, a detector system comprising a first detector arrangement arranged in such a way that the signal beam and the reference beam are incident upon the first detector arrangement with the reference beam propagating at an angle relative to a signal beam, and wherein the first......The present invention relates to a compact, reliable and low-cost vector velocimeter for example for determining velocities of particles suspended in a gas or fluid flow, or for determining velocity, displacement, rotation, or vibration of a solid surface, the vector velocimeter comprising a laser...... assembly for emission of a measurement beam for illumination of an object in a measurement volume with coherent light whereby a signal beam emanating from the object in the measurement volume is formed in response to illumination of the object by the measurement beam, a reference beam generator...

  12. Single-trial normalization for event-related spectral decomposition reduces sensitivity to noisy trials

    Directory of Open Access Journals (Sweden)

    Romain eGrandchamp

    2011-09-01

    Full Text Available In EEG research, the classical Event-Related Potential (ERP model often proves to be a limited method when studying complex brain dynamics. For this reason, spectral techniques adapted from signal processing such as Event-Related Spectral Perturbation (ERSP – and its variant ERS (Event-Related Synchronization and ERD (Event-Related Desynchronization – have been used over the past 20-years. They represent average spectral changes in response to a stimulus.These spectral methods do not have strong consensus for comparing pre and post-stimulus activity. When computing ERSP, pre-stimulus baseline removal is usually performed after averaging the spectral estimate of multiple trials. Correcting the baseline of each single-trial prior to averaging spectral estimates is an alternative baseline correction method. However, we show that this method leads to positively skewed post-stimulus ERSP values. We eventually present new single-trial based ERSP baseline correction methods that perform trial normalization or centering prior to applying classical baseline correction methods. We show that single-trial correction methods minimize the contribution of artifactual data trials with high-amplitude spectral estimates and are robust to outliers when performing statistical inference testing. We then characterize these methods in terms of their time-frequency responses and behavior when performing statistical inference testing compared to classical ERSP methods.

  13. Age-related cognitive decline during normal aging: the complex effect of education.

    Science.gov (United States)

    Ardila, A; Ostrosky-Solis, F; Rosselli, M; Gómez, C

    2000-08-01

    The purpose of this study was to further analyze the effects of education on cognitive decline during normal aging. An 806-subject sample was taken from five different Mexican regions. Participants ranged in age from 16 to 85 years. Subjects were grouped into four educational levels: illiterate, 1-4, 5-9, and 10 or more years of education, and four age ranges: 16-30, 31-50, 51-65, and 66-85 years. A brief neuropsychological test battery (NEUROPSI), standardized and normalized in Spanish, was administered. The NEUROPSI test battery includes assessment of orientation, attention, memory, language, visuoperceptual abilities, motor skills, and executive functions. In general, test scores were strongly associated with level of educational, and differences among age groups were smaller than differences among education groups. However, there was an interaction between age and education such as that among illiterate individuals scores of participants 31-50 years old were higher than scores of participants 16-30 years old for over 50% of the tests. Different patterns of interaction among educational groups were distinguished. It was concluded that: (a) The course of life-span changes in cognition are affected by education. Among individuals with a low level of education, best neuropsychological test performance is observed at an older age than among higher-educated subjects; and (b) there is not a single relationship between age-related cognitive decline and education, but different patterns may be found, depending upon the specific cognitive domain.

  14. Age-related changes in intracranial compartment volumes in normal adults assessed by magnetic resonance imaging.

    Science.gov (United States)

    Matsumae, M; Kikinis, R; Mórocz, I A; Lorenzo, A V; Sándor, T; Albert, M S; Black, P M; Jolesz, F A

    1996-06-01

    Magnetic resonance (MR) image-based computerized segmentation was used to measure various intracranial compartments in 49 normal volunteers ranging in age from 24 to 80 years to determine age-related changes in brain, ventricular, and extraventricular cerebrospinal fluid (CSF) volumes. The total intracranial volume (sum of brain, ventricular, and extraventricular CSF) averaged 1469 +/- 102 cm3 in men and 1289 +/- 111 cm3 in women. The difference was attributable primarily to brain volume, which accounted for 88.6% of the respective intracranial volumes in both sexes, but was significantly larger in men (1302 +/- 112 cm3) than in women (1143 +/- 105 cm3). In both, the cranial CSF volume averaged 11.4%. Total intracranial volume did not change with age, although the normalized brain volume of both men and women began to decrease after the age of 40 years. This decrease was best reflected by expansion of the extraventricular CSF volume which, after the age of 50 years, was more marked in men than in women. The volume of the cranial CSF, as determined by MR image-based computerized segmentation, is considerably larger than traditionally accepted and resides mostly extraventricularly. Expansion of CSF volume with age provides a good index of brain shrinkage although evolving changes and growth of the head with age tend to confound the results.

  15. Face-name Associative Memory Performance is Related To Amyloid Burden in Normal Elderly

    Science.gov (United States)

    Rentz, Dorene M.; Amariglio, Rebecca. E.; Becker, J. Alex; Frey, Meghan; Olson, Lauren E.; Frishe, Katherine; Carmasin, Jeremy; Maye, Jacqueline E.; Johnson, Keith A.; Sperling, Reisa A.

    2011-01-01

    Cerebral amyloid beta (Aβ) deposition occurs in a substantial fraction of cognitively normal (CN) older individuals. However, it has been difficult to reliably detect evidence of amyloid-related cognitive alterations in CN using standard neuropsychological measures. We sought to determine whether a highly demanding face-name associative memory exam (FNAME) could detect evidence of Aβ-related memory impairment in CN. We studied 45 CN subjects (mean age = 71.7 ± 8.8) with Clinical Dementia Rating (CDR) scores = 0 and MMSE ≥ 28, using Positron Emission Tomography with Pittsburgh Compound B (PiB PET). Memory factor scores were derived from a principal components analysis for FNAME name retrieval (FN-N), FNAME occupation retrieval (FN-O) and the 6-Trial Selective Reminding Test (SRT). Using multiple linear and logistic regression analyses, we related the memory factor scores to PiB distribution volume ratios (DVR, cerebellar reference) as either a continuous or a dichotomous variable in frontal cortex and a posterior cortical region representing the precuneus, posterior cingulate and lateral parietal cortices (PPCLP), co-varying for age and AMNART IQ (a proxy of cognitive reserve (CR)). A significant inverse relationship for FN-N was found with Aβ deposition in frontal (R2 = .29, β = −2.2, p = 0.02) and PPCLP cortices (R2 = .26, β = −2.4, p = 0.05). In contrast, neither FN-O nor the SRT were significantly related to Aβ deposition. Performance on a demanding test of face-name associative memory was related to Aβ burden in brain regions associated with memory systems. Associative memory for faces and names, a common complaint among older adults, may be a sensitive marker of early Aβ-related impairment. PMID:21689670

  16. Face-name associative memory performance is related to amyloid burden in normal elderly.

    Science.gov (United States)

    Rentz, Dorene M; Amariglio, Rebecca E; Becker, J Alex; Frey, Meghan; Olson, Lauren E; Frishe, Katherine; Carmasin, Jeremy; Maye, Jacqueline E; Johnson, Keith A; Sperling, Reisa A

    2011-07-01

    Cerebral amyloid beta (Aβ) deposition occurs in a substantial fraction of cognitively normal (CN) older individuals. However, it has been difficult to reliably detect evidence of amyloid-related cognitive alterations in CN using standard neuropsychological measures. We sought to determine whether a highly demanding face-name associative memory exam (FNAME) could detect evidence of Aβ-related memory impairment in CN. We studied 45 CN subjects (mean age=71.7 ± 8.8) with Clinical Dementia Rating (CDR) scores=0 and MMSE ≥ 28, using Positron Emission Tomography with Pittsburgh Compound B (PiB PET). Memory factor scores were derived from a principal components analysis for FNAME name retrieval (FN-N), FNAME occupation retrieval (FN-O) and the 6-Trial Selective Reminding Test (SRT). Using multiple linear and logistic regression analyses, we related the memory factor scores to PiB distribution volume ratios (DVR, cerebellar reference) as either a continuous or a dichotomous variable in frontal cortex and a posterior cortical region representing the precuneus, posterior cingulate and lateral parietal cortices (PPCLP), co-varying for age and AMNART IQ (a proxy of cognitive reserve (CR)). A significant inverse relationship for FN-N was found with Aβ deposition in frontal (R(2)=0.29, β=-2.2, p=0.02) and PPCLP cortices (R(2)=0.26, β=-2.4, p=0.05). In contrast, neither FN-O nor the SRT were significantly related to Aβ deposition. Performance on a demanding test of face-name associative memory was related to Aβ burden in brain regions associated with memory systems. Associative memory for faces and names, a common complaint among older adults, may be a sensitive marker of early Aβ-related impairment.

  17. AGE-RELATED CHANGES OF BONE MARROW OF NORMAL ADULT MAN ON DIFFUSION WEIGHTED IMAGING

    Institute of Scientific and Technical Information of China (English)

    Chun-yan Zhang; Rong Rong; Xiao-ying Wang

    2008-01-01

    Objective To investigate the signal intensity and apparent diffusion coefficient (ADC) of bone marrow of normal adult man on diffusion weighted imaging (DWI).Methods Fifteen healthy volunteers and thirty-eight patients with benign prostatic hyperplasia or normal prostate were enrolled in this study, with age range 28-82 years old (mean 55.26 ± 18.05 years). All people were examined with large field DWI on a 3.0T magnetic resonance scanner, which ranges from the top of head to the lower limb. The signal-to-noise ratio (SNR) on the DWI and ADC of lumber vertebra at renal hilum level, left ilium and superior segment of left femur were measured. The measured SNR and ADC value of the above sites were compared by one way analysis of variance and their correlations with age were investigated by Pearson's correlation analysis. Results The SNR of lumber vertebra, left ilium and left femur showed no significant difference (F = 0.271, P = 0.763). The SNR of lumber vertebra (r = 0.309, P = 0.024) and left ilium (r = 0.359, P = 0.008) showed positive correlation with age, while the SNR of left femur showed no correlation with age (r = -0.163, P = 0.283). The ADC of lumber vertebra [(0.617 ± 0.177) ×10-3 mm2/s] was significantly higher than that of left ilium [(0.404 ± 0.112)×10-3 mm2/ P < 0.001] and left femur [(0.362 ± 0.092)×10-3mm2/s, P < 0.001], while the ADC of left ilium and left femur had no significant difference. The ADC of lumber vertebra, left ilium and left femur showed no correlation with age. Conclusion Understanding of age-related changes of normal adult bone marrow on DWI is very important to differentiate the normal bone marrow and abnormal lesions.

  18. Seismic imaging of deformation zones associated with normal fault-related folding

    Science.gov (United States)

    Lapadat, Alexandru; Imber, Jonathan; Iacopini, David; Hobbs, Richard

    2016-04-01

    Folds associated with normal faulting, which are mainly the result of fault propagation and linkage of normal fault segments, can exhibit complex deformation patterns, with multiple synthetic splay faults, reverse faults and small antithetic Riedel structures accommodating flexure of the beds. Their identification is critical in evaluating connectivity of potential hydrocarbon reservoirs and sealing capacity of faults. Previous research showed that seismic attributes can be successfully used to image complex structures and deformation distribution in submarine thrust folds. We use seismic trace and coherency attributes, a combination of instantaneous phase, tensor discontinuity and semblance attributes to identify deformation structures at the limit of seismic resolution, which accommodate seismic scale folding associated with normal faulting from Inner Moray Firth Basin, offshore Scotland. We identify synthetic splay faults and reverse faults adjacent to the master normal faults, which are localized in areas with highest fold amplitudes. This zone of small scale faulting is the widest in areas with highest fault throw / fold amplitude, or where a bend is present in the main fault surface. We also explore the possibility that changes in elastic properties of the rocks due to deformation can contribute to amplitude reductions in the fault damage zones. We analyse a pre-stack time-migrated 3D seismic data-set, where seismic reflections corresponding to a regionally-continuous and homogeneous carbonate layer display a positive correlation between strain distribution and amplitude variations adjacent to the faults. Seismic amplitude values are homogeneously distributed within the undeformed area of the footwall, with a minimum deviation from a mean amplitude value calculated for each seismic line. Meanwhile, the amplitude dimming zone is more pronounced (negative deviation increases) and widens within the relay zone, where sub-seismic scale faults, which accommodate

  19. Normal pressure hydrocephalus, a possible complication in IgG4-related disease

    Directory of Open Access Journals (Sweden)

    Hiroshi Kobayashi

    2016-09-01

    Full Text Available We report a 75-year-old man with glucocorticoid-responsive normal pressure hydrocephalus (NPH complicated with tubulointerstitial renal disease, protein-losing gastroenteropathy (PLG and elevated serum IgG4, which might be a possible subset of IgG4-related disease (IgG4-RD. Although either PLG or NPH, especially in combination, has rarely been reported in IgG4-RD, the glucocorticoid-responsive nature of every abnormality observed in the patient supports the diagnosis of IgG4-RD. Of course, pathological confirmation is essential to fulfill the recently raised diagnostic criteria, however, such invasive procedure might not always be indicated in high-risk patients. Our report illustrates that IgG4-RD might be considered as one of the underlying causes and/or the aggravating factors of NPH before shunt operation.

  20. Body composition in normal subjects: relation to lipid and glucose variables

    DEFF Research Database (Denmark)

    Rosenfalck, A M; Almdal, Thomas Peter; Gotfredsen, A;

    1996-01-01

    OBJECTIVE: To describe sex- and age-dependent values of total and regional body composition as determined by dual-energy X-ray absorptiometry (DXA) in normal subjects, and furthermore to relate body composition measurements to blood lipids, glucose and insulin concentrations. DESIGN: A cross...... subjects. In 87 of the subjects fasting blood glucose, S-insulin and lipid profile were measured. RESULTS: The study population was for each sex divided into five decades for which results on body composition and blood lipids are presented. Body weight increased 2 kg per age decade, representing......-sectional study. SUBJECTS: 173 (84 male and 89 female) healthy subjects, BMI Body composition parameters including data on total bone mineral content (TBMC), total bone mineral density (TBMD), lean body soft tissue mass (LTM), total and regional fat mass (FM) were estimated in all...

  1. Intra-operative Vector Flow Imaging Using Ultrasound of the Ascending Aorta among 40 Patients with Normal, Stenotic and Replaced Aortic Valves

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Lindskov; Møller-Sørensen, Hasse; Kjaergaard, Jesper

    2016-01-01

    Stenosis of the aortic valve gives rise to more complex blood flows with increased velocities. The angleindependent vector flow ultrasound technique transverse oscillation was employed intra-operatively on the ascending aorta of (I) 20 patients with a healthy aortic valve and 20 patients with aor......Stenosis of the aortic valve gives rise to more complex blood flows with increased velocities. The angleindependent vector flow ultrasound technique transverse oscillation was employed intra-operatively on the ascending aorta of (I) 20 patients with a healthy aortic valve and 20 patients...... (p , 0.52 and p , 0.22), but flow complexity was not (p , 0.0001). Flow complexity (p , 0.0001), systolic jet width (p , 0.0001) and systolic backflow (p , 0.001) were associated with peak systolic velocity. The study found that aortic stenosis changes blood flow in the ascending aorta and valve...

  2. Vector velocimeter

    DEFF Research Database (Denmark)

    2012-01-01

    The present invention relates to a compact, reliable and low-cost vector velocimeter for example for determining velocities of particles suspended in a gas or fluid flow, or for determining velocity, displacement, rotation, or vibration of a solid surface, the vector velocimeter comprising a laser...... assembly for emission of a measurement beam for illumination of an object in a measurement volume with coherent light whereby a signal beam emanating from the object in the measurement volume is formed in response to illumination of the object by the measurement beam, a reference beam generator...... detector element signal when the fringe pattern formed by the interfering signal beam and reference beam moves across the first detector array; and a signal processor that is adapted for generation of a velocity signal corresponding to a first velocity component of movement of the object in the measurement...

  3. Local Renin-Angiotensin System in Normal Hematopoietic and Multiple Myeloma-Related Progenitor Cells

    Directory of Open Access Journals (Sweden)

    Burak Uz

    2014-03-01

    Full Text Available OBJECTIVE: The prominent functions of the local renin-angiotensin system (RAS in primitive hematopoiesis further support the hypothesis that local autocrine bone marrow RAS could also be active in neoplastic hematopoiesis. The aim of this study is to examine critical RAS elements in normal CD34+ hematopoietic stem cells and multiple myeloma (MM-related progenitor cells. METHODS: The study group comprised the total bone marrow cells (CBM of 10 hematologically normal people, the CD34+ stem cell samples (CD34+CBM of 9 healthy donors for allogeneic peripheral stem cell transplantation, and the CD34+ stem cell samples (CD34+MM of 9 MM patients undergoing autologous peripheral stem cell transplantation. We searched for the gene expression of the major RAS components in healthy hematopoietic cells and myeloma cells by quantitative real-time polymerase chain reaction analysis. RESULTS: RENIN, angiotensinogen (ANGTS, and angiotensin converting enzyme-I (ACE I mRNA expression levels of CBM were significantly higher than those in myeloma patients (p=0.03, p=0.002, and p=0.0008, respectively. Moreover, RENIN and ANGTS mRNA expression levels were significantly higher in CD34+ stem cell samples of healthy allogeneic donors compared to those in myeloma patients (p=0.001 and p=0.01. However, ACE I expression levels were similar in CD34+CBM and CD34+MM hematopoietic cells (p=0.89. CONCLUSION: Although found to be lower than in the CBM and CD34+CBM hematopoietic cells, the local RAS components were also expressed in CD34+MM hematopoietic cells. This point should be kept in mind while focusing on the immunobiology of MM and the processing of autologous cells during the formation of transplantation treatment protocols.

  4. Increased leptin/adiponectin ratio relates to low-normal thyroid function in metabolic syndrome.

    Science.gov (United States)

    van Tienhoven-Wind, Lynnda J N; Dullaart, Robin P F

    2017-01-11

    Low-normal thyroid function within the euthyroid range may contribute to increased atherosclerosis susceptibility. The leptin/adiponectin (L/A) ratio is associated with cardiovascular disease and reflects adipose tissue dysfunction. Relationships of the L/A ratio with low-normal thyroid function are unknown. Relationships of thyroid stimulating hormone (TSH) and free thyroxine (free T4) with leptin, adiponectin and the L/A ratio in euthyroid subjects were documented in 67 fasting subjects with metabolic syndrome (Mets) and 86 euthyroid subjects without MetS (TSH and free T4 levels within the institutional reference range). Neither plasma leptin nor adiponectin was significantly correlated with TSH or free T4 in subjects with and without MetS. In the whole group, high sensitivity C-reactive protein (hs-CRP) was positively correlated with the L/A ratio (r = 0.485, P < 0.001). Notably, the L/A ratio was positively correlated with TSH in subjects with MetS (r = 0.252, P = 0.040) but not in subjects without MetS (r = -0.068, P = 0.54; interaction term, P = 0.027). In MetS subjects, the L/A ratio remained positively related with TSH after adjustment for age, sex, diabetes status, hs-CRP and the use of antihypertensive and glucose lowering medication (β = 0.283, P = 0.018), as well as after adjustment for individual MetS components (β = 0.294, P = 0.020). In the context of MetS, a higher TSH within the euthyroid range confers an increased L/A ratio, a proposed marker of atherosclerosis susceptibility and adipocyte dysfunction.

  5. Vector Soliton Fiber Lasers

    CERN Document Server

    Zhang, Han

    2011-01-01

    Solitons, as stable localized wave packets that can propagate long distance in dispersive media without changing their shapes, are ubiquitous in nonlinear physical systems. Since the first experimental realization of optical bright solitons in the anomalous dispersion single mode fibers (SMF) by Mollenauer et al. in 1980 and optical dark solitons in the normal dispersion SMFs by P. Emplit et al. in 1987, optical solitons in SMFs had been extensively investigated. In reality a SMF always supports two orthogonal polarization modes. Taking fiber birefringence into account, it was later theoretically predicted that various types of vector solitons, including the bright-bright vector solitons, dark-dark vector solitons and dark-bright vector solitons, could be formed in SMFs. However, except the bright-bright type of vector solitons, other types of vector solitons are so far lack of clear experimental evidence. Optical solitons have been observed not only in the SMFs but also in mode locked fiber lasers. It has be...

  6. Genetic Drift during Systemic Arbovirus Infection of Mosquito Vectors Leads to Decreased Relative Fitness during Host Switching.

    Science.gov (United States)

    Grubaugh, Nathan D; Weger-Lucarelli, James; Murrieta, Reyes A; Fauver, Joseph R; Garcia-Luna, Selene M; Prasad, Abhishek N; Black, William C; Ebel, Gregory D

    2016-04-13

    The emergence of mosquito-borne RNA viruses, such as West Nile virus (WNV), is facilitated by genetically complex virus populations within hosts. Here, we determine whether WNV enzootic (Culex tarsalis, Cx. quinquefasciatus, and Cx. pipiens) and bridge vectors (Aedes aegypti) have differential impacts on viral mutational diversity and fitness. During systemic mosquito infection, WNV faced stochastic reductions in genetic diversity that rapidly was recovered during intra-tissue population expansions. Interestingly, this intrahost selection and diversification was mosquito species dependent with Cx. tarsalis and Cx. quinquefasciatus exhibiting greater WNV divergence. However, recovered viral populations contained a preponderance of potentially deleterious mutations (i.e., high mutational load) and had lower relative fitness in avian cells compared to input virus. These findings demonstrate that the adaptive potential associated with mosquito transmission varies depending on the mosquito species and carries a significant fitness cost in vertebrates.

  7. Concentrations of AMH and inhibin-B in relation to follicular diameter in normal human small antral follicles

    DEFF Research Database (Denmark)

    Andersen, Claus Yding; Schmidt, Kirsten Tryde; Kristensen, Stine Gry;

    2010-01-01

    The aim of the present study was to determine the intrafollicular concentrations of anti-Müllerian hormone (AMH), inhibin-B and steroids in normal human small antral follicles and to relate them to follicular size.......The aim of the present study was to determine the intrafollicular concentrations of anti-Müllerian hormone (AMH), inhibin-B and steroids in normal human small antral follicles and to relate them to follicular size....

  8. Predicting distribution of Aedes aegypti and Culex pipiens complex, potential vectors of Rift Valley fever virus in relation to disease epidemics in East Africa

    Directory of Open Access Journals (Sweden)

    Clement Nyamunura Mweya

    2013-10-01

    Full Text Available Background: The East African region has experienced several Rift Valley fever (RVF outbreaks since the 1930s. The objective of this study was to identify distributions of potential disease vectors in relation to disease epidemics. Understanding disease vector potential distributions is a major concern for disease transmission dynamics. Methods: Diverse ecological niche modelling techniques have been developed for this purpose: we present a maximum entropy (Maxent approach for estimating distributions of potential RVF vectors in un-sampled areas in East Africa. We modelled the distribution of two species of mosquitoes (Aedes aegypti and Culex pipiens complex responsible for potential maintenance and amplification of the virus, respectively. Predicted distributions of environmentally suitable areas in East Africa were based on the presence-only occurrence data derived from our entomological study in Ngorongoro District in northern Tanzania. Results: Our model predicted potential suitable areas with high success rates of 90.9% for A. aegypti and 91.6% for C. pipiens complex. Model performance was statistically significantly better than random for both species. Most suitable sites for the two vectors were predicted in central and northwestern Tanzania with previous disease epidemics. Other important risk areas include western Lake Victoria, northern parts of Lake Malawi, and the Rift Valley region of Kenya. Conclusion: Findings from this study show distributions of vectors had biological and epidemiological significance in relation to disease outbreak hotspots, and hence provide guidance for the selection of sampling areas for RVF vectors during inter-epidemic periods.

  9. Mini Review: Relational Stability in the Expression of Normality, Variation and Control of Thyroid Function

    Directory of Open Access Journals (Sweden)

    Rudolf Hoermann

    2016-11-01

    Full Text Available Thyroid hormone concentrations only become sufficient to maintain a euthyroid state through appropriate stimulation by pituitary TSH. In such a dynamic system under constant high pressure, guarding against overstimulation becomes vital. Therefore, several defensive mechanisms protect against accidental overstimulation, such as plasma protein binding, conversion of T4 into the more active T3, active transmembrane transport, counter-regulatory activities of reverse T3 and thyronamines and negative hypothalamic-pituitary-thyroid feedback control of TSH. TSH has gained a dominant but misguided role in interpreting thyroid function testing in assuming that its exceptional sensitivity thereby translates into superior diagnostic performance. However, TSH-dependent thyroid disease classification is heavily influenced by statistical analytic techniques such as uni- or multivariate-defined normality. This demands a separation of its conjoint roles as a sensitive screening test and accurate diagnostic tool. Homeostatic equilibria (set points in healthy subjects are less variable, and do not follow a pattern of random variation, rather indicating signs of early and progressive homeostatic control across the euthyroid range. In the event of imminent thyroid failure with a reduced FT4 output per unit TSH, conversion efficiency increases in order to maintain FT3 stability. In such situations, T3 stability takes priority over set point maintenance. This suggests a concept of relational stability. These findings have important implications for both TSH reference limits and treatment targets for patients on levothyroxine. The use of archival markers is proposed to facilitate the homeostatic interpretation of all parameters.

  10. Relation Between Ghrelin Hormone Levels and Bone Mineral Density in Normal Adults

    Directory of Open Access Journals (Sweden)

    Y Naghiaee

    2011-08-01

    Full Text Available Introduction: Ghrelin hormone is a polypeptide with 28 amino acids that is secreted along the gastrointestinal tract, mainly in fundus of stomach. Some physiological functions of ghrelin include increase of appetite and food intake, energy balance, stimulation of growth hormone secretion and heart output and decrease in blood pressure. Recently, relation of ghrelin and bone mineral density has been considered. Methods: This descriptive study included 33 adult persons above 20 years of age. Bone mineral density was determined with dual energy x-ray absorptiometry in femur and lumbar regions. T-score over than -1 was considered as normal case. Ghrelin levels were determined by ELISA method. Results: The mean of age, body mass index and serum ghrelin were 40±10.6years, 27±3.6 kg/m² and 100.5±128 pg/ml, respectively. Correlation of ghrelin and variables was not statistically significant except weight (p=0.05. Conclusion: Range of serum ghrelin levels varies with age. In the present research, there was no relationship between ghrelin levels and bone mineral density in femur and lumbar regions. More studies with larger number of samples are proposed.

  11. Auditory event-related brain potentials for an early discrimination between normal and pathological brain aging

    Institute of Scientific and Technical Information of China (English)

    Juliana Dushanova; Mario Christov

    2013-01-01

    The brain as a system with gradually decreasing resources maximizes its chances by reorganizing neural networks to ensure efficient performance. Auditory event-related potentials were recorded in 28 healthy volunteers comprising 14 young and 14 elderly subjects in auditory discrimination motor task (low frequency tone – right hand movement and high frequency tone – left hand movement). The amplitudes of the sensory event-related potential components (N1, P2) were more pronounced with increasing age for either tone and this effect for P2 amplitude was more pronounced in the frontal region. The latency relationship of N1 between the groups was tone-dependent, while that of P2 was tone-independent with a prominent delay in the elderly group over all brain regions. The amplitudes of the cognitive components (N2, P3) diminished with increasing age and the hemispheric asymmetry of N2 (but not for P3) reduced with increasing age. Prolonged N2 latency with increasing age was widespread for either tone while between-group difference in P3 latency was tone-dependent. High frequency tone stimulation and movement requirements lead to P3 delay in the elderly group. The amplitude difference of the sensory components between the age groups could be due to a general greater alertness, less expressed habituation, or decline in the ability to retreat attentional resources from the stimuli in the elderly group. With aging, a neural circuit reorganization of the brain activity affects the cognitive processes. The approach used in this study is useful for an early discrimination between normal and pathological brain aging for early treatment of cognitive alterations and dementia.

  12. Vertebrate Ticks Distribution and Their Role as Vectors in Relation to Road Edges and Underpasses.

    Science.gov (United States)

    Delgado, Juan D; Abreu-Yanes, Estefanía; Abreu-Acosta, Néstor; Flor, Manuel D; Foronda, Pilar

    2017-06-01

    Roads fragment vertebrate populations and affect the dynamics and dispersal patterns of vertebrate parasites. We evaluated how vertebrate ticks distribute near roads and road underpasses in human-caused road-fragmented landscapes in Seville, SW Spain. We sampled 49 stations with 93 individualized sampling points and assessed tick abundance. We explored the relationship between tick presence and abundance and distance to the nearest road and underpass (drainage culverts and other passages used by vertebrates), and landscape features through categorical regression and nonparametric statistics. The presence of the tick-borne pathogens Borrelia sp. and Bartonella sp. was also analyzed by PCR. We found preliminary evidence of high relative tick abundance next to roads and in the vicinity of road underpasses. Plant cover type was related to tick presence in this road context. Implications of road permeability and edge effect in patterns of vertebrate-tick relationships in road fragmentation contexts are discussed. Both Borrelia sp. and Bartonella sp. were detected in the ticks analyzed. This is the first report of these bacteria in ticks from Seville. The results confirm the potential risk of acquiring Lyme disease and bartonellosis in this area.

  13. Plant Virus Differentially Alters the Plant's Defense Response to Its Closely Related Vectors

    Science.gov (United States)

    Shi, Xiaobin; Pan, Huipeng; Xie, Wen; Wu, Qingjun; Wang, Shaoli; Liu, Yang; Fang, Yong; Chen, Gong; Gao, Xiwu; Zhang, Youjun

    2013-01-01

    Background The whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae), is one of the most widely distributed agricultural pests. In recent years, B. tabaci Q has invaded China, and Q has displaced B in many areas now. In a number of regions of the world, invasion by B and/or Q has been followed by outbreaks of tomato yellow leaf curl virus (TYLCV). Our previous study showed TYLCV directly and indirectly modified the feeding behavior of B. tabaci in favor of Q rather than B. Methodology/Principal Findings In this study, we quantified the salicylic acid (SA) titers and relative gene expression of SA in tomato leaves that were infested with viruliferous or non-viruliferous B and Q. We also measured the impacts of exogenous SA on the performance of B and Q, including the effects on ovary development. SA titer was always higher in leaves that were infested with viruliferous B than with viruliferous Q, whereas the SA titer did not differ between leaves infested with non-viruliferous B and Q. The relative gene expression of SA signaling was increased by feeding of viruliferous B but was not increased by feeding of viruliferous Q. The life history traits of B and Q were adversely affected on SA-treated plants. On SA-treated plants, both B and Q had lower fecundity, shorter longevity, longer developmental time and lower survival rate than on untreated plants. Compared with whiteflies feeding on control plants, those feeding on SA-treated plants had fewer oocytes and slower ovary development. On SA-treated plants, viruliferous B had fewer oocytes than viruliferous Q. Conclusions/Significance These results indicate that TYLCV tends to induce SA-regulated plant defense against B but SA-regulated plant defense against Q was reduced. In other words, Q may have a mutualistic relationship with TYLCV that results in the reduction of the plant's defense response. PMID:24391779

  14. MosquitoMap and the Mal-area calculator: new web tools to relate mosquito species distribution with vector borne disease.

    Science.gov (United States)

    Foley, Desmond H; Wilkerson, Richard C; Birney, Ian; Harrison, Stanley; Christensen, Jamie; Rueda, Leopoldo M

    2010-02-18

    Mosquitoes are important vectors of diseases but, in spite of various mosquito faunistic surveys globally, there is a need for a spatial online database of mosquito collection data and distribution summaries. Such a resource could provide entomologists with the results of previous mosquito surveys, and vector disease control workers, preventative medicine practitioners, and health planners with information relating mosquito distribution to vector-borne disease risk. A web application called MosquitoMap was constructed comprising mosquito collection point data stored in an ArcGIS 9.3 Server/SQL geodatabase that includes administrative area and vector species x country lookup tables. In addition to the layer containing mosquito collection points, other map layers were made available including environmental, and vector and pathogen/disease distribution layers. An application within MosquitoMap called the Mal-area calculator (MAC) was constructed to quantify the area of overlap, for any area of interest, of vector, human, and disease distribution models. Data standards for mosquito records were developed for MosquitoMap. MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting. The MAC quantifies the Mal-area, i.e. the area where it is theoretically possible for vector-borne disease transmission to occur, thus providing a useful decision tool where other disease information is limited. The Mal-area approach emphasizes the independent but cumulative contribution to disease risk of the vector species predicted present. MosquitoMap adds value to, and makes accessible, the results of past collecting efforts, as well as providing a template for other arthropod spatial databases.

  15. Studies on seasonal fluctuation of different indices related to filarial vector,Culex quinquefasciatus around foothills of Susunia of West Bengal, India

    Institute of Scientific and Technical Information of China (English)

    Manas Paramanik; Goutam Chandra

    2010-01-01

    Objective:To collect information on the seasonal activity of filarial vector around foothills of Susunia of West Bengal, India.Methods: Indoor-resting mosquitoes were collected from the human habitations of16 villages. Collected mosquitoes were identified and examined for different parameters following standard methods recommended by World Health Organization and pioneer workers.Results: Overall man hour density, infection rate, infectivity rate, human blood index and daily mortality rate of the vector were assessed as10.54%, 6.31%, 1.38%, 77.33% and13.00%, respectively, which were12.17%, 8.63%, 2.26%, 100.00% and17.00%, respectively in the summer season. Average load of microfilaria,1st stage,2nd stage and3rd stage larvae ofWuchereria bancrofti in infected vectors were10.02, 7.50, 5.56 and4.68, respectively, which were11.58, 9.90, 6.27and5.44, respectively in summer. Among the searched shelters 63.37%, 8.16% and2.08% were found to be invaded by any vector, infected vector and infective vector, respectively, which were68.75%,12.76% and3.91%, respectively in summer.Conclusions: Different indices related to the vector were much higher in summer, which indicates that, summer is the most favorable season for transmission of lymphatic filariasis in the study area. Available data will help to formulate an effective vector control measure.

  16. Multi-temporal and multi-source remote sensing image classification by nonlinear relative normalization

    Science.gov (United States)

    Tuia, Devis; Marcos, Diego; Camps-Valls, Gustau

    2016-10-01

    Remote sensing image classification exploiting multiple sensors is a very challenging problem: data from different modalities are affected by spectral distortions and mis-alignments of all kinds, and this hampers re-using models built for one image to be used successfully in other scenes. In order to adapt and transfer models across image acquisitions, one must be able to cope with datasets that are not co-registered, acquired under different illumination and atmospheric conditions, by different sensors, and with scarce ground references. Traditionally, methods based on histogram matching have been used. However, they fail when densities have very different shapes or when there is no corresponding band to be matched between the images. An alternative builds upon manifold alignment. Manifold alignment performs a multidimensional relative normalization of the data prior to product generation that can cope with data of different dimensionality (e.g. different number of bands) and possibly unpaired examples. Aligning data distributions is an appealing strategy, since it allows to provide data spaces that are more similar to each other, regardless of the subsequent use of the transformed data. In this paper, we study a methodology that aligns data from different domains in a nonlinear way through kernelization. We introduce the Kernel Manifold Alignment (KEMA) method, which provides a flexible and discriminative projection map, exploits only a few labeled samples (or semantic ties) in each domain, and reduces to solving a generalized eigenvalue problem. We successfully test KEMA in multi-temporal and multi-source very high resolution classification tasks, as well as on the task of making a model invariant to shadowing for hyperspectral imaging.

  17. About vectors

    CERN Document Server

    Hoffmann, Banesh

    1975-01-01

    From his unusual beginning in ""Defining a vector"" to his final comments on ""What then is a vector?"" author Banesh Hoffmann has written a book that is provocative and unconventional. In his emphasis on the unresolved issue of defining a vector, Hoffmann mixes pure and applied mathematics without using calculus. The result is a treatment that can serve as a supplement and corrective to textbooks, as well as collateral reading in all courses that deal with vectors. Major topics include vectors and the parallelogram law; algebraic notation and basic ideas; vector algebra; scalars and scalar p

  18. Vector analysis

    CERN Document Server

    Newell, Homer E

    2006-01-01

    When employed with skill and understanding, vector analysis can be a practical and powerful tool. This text develops the algebra and calculus of vectors in a manner useful to physicists and engineers. Numerous exercises (with answers) not only provide practice in manipulation but also help establish students' physical and geometric intuition in regard to vectors and vector concepts.Part I, the basic portion of the text, consists of a thorough treatment of vector algebra and the vector calculus. Part II presents the illustrative matter, demonstrating applications to kinematics, mechanics, and e

  19. Some Results on Unicity of Entire Functions Related to Normal Families

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    This paper studied the connection between normal family and unicity, and proved some results on unicity of entire functions. Mostly, it was proved: Let f be a nonconstant entire function, and let a, c be two nonzero complex numbers. If E(a,f)=E(a,f), and f"(z)=c whenever f' (z)=a, then f(z)=Aecz/a+ac-a2/c. The proof uses the theory of normal families in an essential way.

  20. Age-related changes of the diffusion tensor imaging parameters of the normal cervical spinal cord

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Kun, E-mail: medsciwangkun@126.com [Orthopedics Department, Changhai Hospital Affiliated to Second Military Medical University, Shanghai (China); Song, Qingxin; Zhang, Fan; Chen, Zhi; Hou, Canglong; Tang, Yixing [Orthopedics Department, Changhai Hospital Affiliated to Second Military Medical University, Shanghai (China); Chen, Shiyue [Radiology Department, Changhai Hospital Affiliated to Second Military Medical University, Shanghai (China); Hao, Qiang, E-mail: haoqiang@189.cn [Radiology Department, Changhai Hospital Affiliated to Second Military Medical University, Shanghai (China); Shen, Hongxing, E-mail: shenhxgk@126.com [Orthopedics Department, Changhai Hospital Affiliated to Second Military Medical University, Shanghai (China)

    2014-12-15

    Highlights: • It is essential to determine the DTI parameters in the whole CSC. • To analyze DTI parameters in all intervertebral space levels of the CSC. • To study the impact of age on these parameters in healthy Chinese subjects. • Provide better insights in factors that could bias the diagnosis of CSC pathologies. - Abstract: Background: The diffusion tensor imaging (DTI) parameters of the cervical spinal cord (CSC) changes with age. However, previous studies only examined specific CSC areas. Objectives: To analyze the DTI parameters in all intervertebral space levels of the whole normal CSC and to study the impact of age on these parameters in a Chinese population. Methods: Thirty-six healthy subjects aged 20–77 years were recruited. DTI parameters were calculated for gray matter (GM) and white matter (WM) funiculi in all the CSC intervertebral spaces (C1/2-C6/7). Age-related changes of DTI parameters were analyzed for the GM and WM funiculi. Results: Fractional anisotropy (FA) and mean diffusivity (MD) were lower in GM than in WM. MD and FA values were lower in the WM in the lower CSC compared with the upper CSC (all P < 0.05), but no difference was observed in GM. In ventral funiculi, MD increased with age, while FA decreased (all P < 0.001). In lateral and dorsal funiculi, MD and FA decreased with age (all P < 0.001). In GM, MD and FA decreased with age (all P < 0.001). Significant age-related changes were observed in FA and MD from GM and WM funiculi. FA was correlated with age in all funiculi (ventral: r = −0.733; lateral: r = −0.468; dorsal: r = −0.607; GM: r = −0.724; all P < 0.01). Conclusion: Important changes in MD and FA were observed with advancing age at all levels of CSC in Chinese patients. DTI parameters may be useful to assess CSC pathology, but the influence of age and segments need to be taken into account in diagnosis.

  1. Image Coding Based on Address Vector Quantization.

    Science.gov (United States)

    Feng, Yushu

    Image coding is finding increased application in teleconferencing, archiving, and remote sensing. This thesis investigates the potential of Vector Quantization (VQ), a relatively new source coding technique, for compression of monochromatic and color images. Extensions of the Vector Quantization technique to the Address Vector Quantization method have been investigated. In Vector Quantization, the image data to be encoded are first processed to yield a set of vectors. A codeword from the codebook which best matches the input image vector is then selected. Compression is achieved by replacing the image vector with the index of the code-word which produced the best match, the index is sent to the channel. Reconstruction of the image is done by using a table lookup technique, where the label is simply used as an address for a table containing the representative vectors. A code-book of representative vectors (codewords) is generated using an iterative clustering algorithm such as K-means, or the generalized Lloyd algorithm. A review of different Vector Quantization techniques are given in chapter 1. Chapter 2 gives an overview of codebook design methods including the Kohonen neural network to design codebook. During the encoding process, the correlation of the address is considered and Address Vector Quantization is developed for color image and monochrome image coding. Address VQ which includes static and dynamic processes is introduced in chapter 3. In order to overcome the problems in Hierarchical VQ, Multi-layer Address Vector Quantization is proposed in chapter 4. This approach gives the same performance as that of the normal VQ scheme but the bit rate is about 1/2 to 1/3 as that of the normal VQ method. In chapter 5, a Dynamic Finite State VQ based on a probability transition matrix to select the best subcodebook to encode the image is developed. In chapter 6, a new adaptive vector quantization scheme, suitable for color video coding, called "A Self -Organizing

  2. Survey on normal distributions,central limit theorem,Brownian motion and the related stochastic calculus under sublinear expectations

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    This is a survey on normal distributions and the related central limit theorem under sublinear expectation.We also present Brownian motion under sublinear expectations and the related stochastic calculus of It?’s type.The results provide new and robust tools for the problem of probability model uncertainty arising in financial risk,statistics and other industrial problems.

  3. Survey on normal distributions, central limit theorem, Brownian motion and the related stochastic calculus under sublinear expectations

    Institute of Scientific and Technical Information of China (English)

    PENG ShiGe

    2009-01-01

    This is a survey on normal distributions and the related central limit theorem under sublinear expectation. We also present Brownian motion under sublinear expectations and the related stochastic calculus of Ito's type. The results provide new and robust tools for the problem of probability model uncertainty arising in financial risk, statistics and other industrial problems.

  4. Knowledge and practices related to dengue and its vector: a community-based study from Southeast Brazil

    Directory of Open Access Journals (Sweden)

    Adorama Candido Alves

    2016-04-01

    Full Text Available Abstract INTRODUCTION: This study investigated the knowledge of users of primary healthcare services living in Ribeirão Preto, Brazil, about dengue and its vector. METHODS: A cross-sectional survey of 605 people was conducted following a major dengue outbreak in 2013. RESULTS: Participants with higher levels of education were more likely to identify correctly the vector of the disease. CONCLUSIONS: The results emphasize the relevance of health education programs, the continuous promotion of educational campaigns in the media, the role of the television as a source of information, and the importance of motivating the population to control the vector.

  5. β-amyloid, hippocampal atrophy and their relation to longitudinal brain change in cognitively normal individuals.

    Science.gov (United States)

    Fletcher, Evan; Villeneuve, Sylvia; Maillard, Pauline; Harvey, Danielle; Reed, Bruce; Jagust, William; DeCarli, Charles

    2016-04-01

    Recent literature has examined baseline hippocampal volume and extent of brain amyloidosis to test potential synergistic effects on worsening cognition and extent of brain atrophy. Use of hippocampal volume in prior studies was based on the notion that limbic circuit degeneration is an early manifestation of the Alzheimer's Disease (AD) pathophysiology. To clarify these interactions early in the AD process, we tested the effects of amyloid and baseline normalized hippocampal volume on longitudinal brain atrophy rates in a group of cognitively normal individuals. Results showed that the combination of elevated β-amyloid and baseline hippocampal atrophy is associated with increased rates specific to the limbic circuit and splenium. Importantly, this atrophy pattern emerged from a voxelwise analysis, corroborated by regression models over region of interests in native space. The results are broadly consistent with previous studies of the effects of amyloid and baseline hippocampal atrophy in normals, while pointing to accelerated atrophy of AD-vulnerable regions detectable at the preclinical stage.

  6. Diagrammatic Approach for Complete Automation of Relational Database Normalization at Conceptual Level

    Directory of Open Access Journals (Sweden)

    M.S. Patwardhan

    2010-11-01

    Full Text Available AER (Articulated Entity Relationship diagrams proposed by us, are the extension of EntityRelationship (ER diagrams to accommodate functional dependencies (FDs as their integral part.Accommodation of FDs in ER diagram helps to achieve total and unconditional automation of relationaldatabase normalization. In this paper we have implemented a software Integrated DevelopmentEnvironment (IDE, called AER IDE, designed by extending the Graphical Editing Framework (GEF andDraw2d plug-in functionality of Eclipse. The AER IDE helps to draw, validate, store and normalize AERdiagrams. An AER IDE has five modules. AER Editor allows creation and edition of AER diagrams usingModel View controller (MVC approach. AER diagrams are translated and stored as an xml file. AERValidator provides the facility of AER diagram validation based on a set of proposed rules. AERNormalizer allows normalization of an AER diagram, in one go, with the help of the proposed AERnormalization rules and algorithms. Thus, it allows the total and unconditional automation of relationaldatabase normalization up to a given normal form; as an integral part of AER IDE. It also serves as avisual aid for the normalization process which is always easy to understand and interpret rather thantheoretical approach. AER-XML Bidirectional Translator provides the import and export functionality ofAER diagram, to and from an XML template making it compatible with the other toolset. AER-SQLGenerator generates DDL scripts in the SQL schema format. The AER IDE is tested with ten distinct AERdiagrams with all possible combinations of AER features and validation rules.

  7. The biology of xylem fluid-feeding insect vectors of Xylella fastidiosa and their relation to disease epidemiology.

    Science.gov (United States)

    Redak, Richard A; Purcell, Alexander H; Lopes, João R S; Blua, Matthew J; Mizell, Russell F; Andersen, Peter C

    2004-01-01

    Xylophagous leafhopppers are common and abundant insects of tropical and subtropical environments and play important ecological roles in these ecosystems. The feeding biology of these insects is unique in terms of their high feeding rates and a digestive physiology that allows them to assimilate amino acids, organic acids, and sugars at approximately 99% efficiency. For those species well studied, fluctuations in plant xylem chemistry and tension appear to determine the diurnal and seasonal use of their host plants. Relatively few species of xylem fluid-feeding leafhoppers are considered important pests in commercial agriculture, as they transmit the bacterial plant pathogen Xylella fastidiosa. X. fastidiosa induces diseases of grapevines, citrus, coffee, almond, alfalfa, stone fruits, landscape ornamentals, and native hardwoods for which there is no cure. Two Xylella diseases, citrus variegated chlorosis (CVC) and Pierce's disease (PD) of grapevines, have emerged as important issues within the past decade. In Brazil, CVC became important in the early 1990s and has now expanded throughout many citrus-growing areas of South America and threatens to spread to North America. The recent establishment of the exotic glassy-winged sharpshooter (Homalodisca coagulata) in California now threatens much of the United States' wine grape, table grape, and almond production. The spread of H. coagulata throughout southern California and the spread of CVC northward from Argentina through Brazil exemplifies the biological risks from exotic species. The occurrence and epidemiology of leafhopper-vectored Xylella diseases are discussed.

  8. Kinematics of the scoliotic spine as related to the normal spine.

    Science.gov (United States)

    Veldhuizen, A G; Scholten, P J

    1987-11-01

    A coupling between the lateral flexion and axial rotation as a result of the geometric arrangement of the motion segments is well known in a normal spine. The kinematic behavior of idiopathic scoliotic spines has been analyzed by means of a biomechanical model study and a radiologic study. The anteroposterior and lateral flexion radiographs of 40 patients with progressive adolescent idiopathic scoliosis were studied. In five of these patients, anteroposterior radiographs were also made with the spine in a ventrally flexed position. The kinematic behavior of a nonpathologic spine was examined by means of a three-dimensional, nonlinear geometric mathematical model of the spine. The frontal plane inclination of the facet joints in conjunction with the vertebral orientation in the sagittal plane influence the kinematic behavior in the normal spine. In a scoliotic spine, there is an axially rotated position and, in most cases, a dorsal inclination (lordotic) of the motion segments. Nevertheless, the direction of the axial rotation during lateral flexion does not differ from the direction of the axial rotation during lateral flexion in a normal spine. The existing axial rotation in idiopathic scoliosis cannot be explained on the basis of spinal kinematics. In contrast to normal spines, in scoliotic spines exists a coupling between ventral flexion or extension and axial rotation. This may be essential in the management of idiopathic scoliosis.

  9. Attitudes of Health Care Providers toward Elderly Patients with Normal Aging and Disease-Related Symptoms.

    Science.gov (United States)

    Baker, Rodney R.

    1984-01-01

    Examined preferences of 275 health care providers for working with elderly patients exhibiting symptoms of normal aging or diseases. In comparing descriptions of two hospitalized patients, physicians, nurses and social workers expressed a preference for working with patients with disease symptoms, raising concerns about geriatric care. (JAC)

  10. Doppler colour flow imaging of fetal intracerebral arteries relative to fetal behavioural states in normal pregnancy

    NARCIS (Netherlands)

    M.J. Noordam (Marja); F.M.E. Hoekstra (Franciska); W.C.J. Hop (Wim); J.W. Wladimiroff (Juriy)

    1994-01-01

    textabstractIn 14 normally developing term fetuses, the relationship between the blood flow velocity waveforms at cerebral arterial level (internal carotid artery, anterior, middle and posterior cerebral artery) and fetal behavioural states was studied using Doppler colour flow imaging. Behavioural

  11. Characterization of disease-related covariance topographies with SSMPCA toolbox: effects of spatial normalization and PET scanners.

    Science.gov (United States)

    Peng, Shichun; Ma, Yilong; Spetsieris, Phoebe G; Mattis, Paul; Feigin, Andrew; Dhawan, Vijay; Eidelberg, David

    2014-05-01

    To generate imaging biomarkers from disease-specific brain networks, we have implemented a general toolbox to rapidly perform scaled subprofile modeling (SSM) based on principal component analysis (PCA) on brain images of patients and normals. This SSMPCA toolbox can define spatial covariance patterns whose expression in individual subjects can discriminate patients from controls or predict behavioral measures. The technique may depend on differences in spatial normalization algorithms and brain imaging systems. We have evaluated the reproducibility of characteristic metabolic patterns generated by SSMPCA in patients with Parkinson's disease (PD). We used [(18) F]fluorodeoxyglucose PET scans from patients with PD and normal controls. Motor-related (PDRP) and cognition-related (PDCP) metabolic patterns were derived from images spatially normalized using four versions of SPM software (spm99, spm2, spm5, and spm8). Differences between these patterns and subject scores were compared across multiple independent groups of patients and control subjects. These patterns and subject scores were highly reproducible with different normalization programs in terms of disease discrimination and cognitive correlation. Subject scores were also comparable in patients with PD imaged across multiple PET scanners. Our findings confirm a very high degree of consistency among brain networks and their clinical correlates in PD using images normalized in four different SPM platforms. SSMPCA toolbox can be used reliably for generating disease-specific imaging biomarkers despite the continued evolution of image preprocessing software in the neuroimaging community. Network expressions can be quantified in individual patients independent of different physical characteristics of PET cameras.

  12. Localization and quantitation of the chromosome 6-encoded dystrophin-related protein in normal and pathological human muscle.

    Science.gov (United States)

    Karpati, G; Carpenter, S; Morris, G E; Davies, K E; Guerin, C; Holland, P

    1993-03-01

    A dystrophin-related protein (DRP) encoded by a gene on chromosome 6 was studied in 14 normal and 79 pathological human skeletal muscle biopsies, as well as in cultured myotubes by light microscopic immunocytochemistry and quantitative immunoblots. In normal muscle immunoreactive DRP was present at the postjunctional surface membrane, at the surface of satellite cells, in the walls of blood vessels, in Schwann cells and in perineurium of intramuscular nerves. All of this produced a weak signal on immunoblots. In Duchenne/Becker dystrophy (DMD/BMD) and in polymyositis (PM) or dermatomyositis (DM) DRP was present throughout the extrajunctional surface membrane of extra- and intrafusal muscle fibers, particularly regenerating ones. This produced a 15-17-fold increase of DRP over normal in DMD/BMD and 4-10-fold increase over normal in PM and DM on immunoblots. In other pathological muscles, DRP localization pattern and quantity was about the same as in normals. Dystrophin-related protein was present in about the same amounts and distribution in normal and DMD cultured myoblasts and myotubes. The molecular stimulus for the marked upregulation of DRP in DMD/BMD and in the inflammatory myopathies is not known. In DMD/BMD the diffuse sarcolemmal DRP may partially compensate for dystrophin deficiency.

  13. Elementary vectors

    CERN Document Server

    Wolstenholme, E Œ

    1978-01-01

    Elementary Vectors, Third Edition serves as an introductory course in vector analysis and is intended to present the theoretical and application aspects of vectors. The book covers topics that rigorously explain and provide definitions, principles, equations, and methods in vector analysis. Applications of vector methods to simple kinematical and dynamical problems; central forces and orbits; and solutions to geometrical problems are discussed as well. This edition of the text also provides an appendix, intended for students, which the author hopes to bridge the gap between theory and appl

  14. Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...... or meromorphic (allowing poles as singularities) functions. There already exists a well-developed theory for iterative holomorphic dynamical systems, and successful relations found between iteration theory and flows of vector fields have been one of the main motivations for the recent interest in holomorphic...

  15. Optical glass: deviation of relative partial dispersion from the normal line-need for a common definition

    Science.gov (United States)

    Hartmann, Peter

    2015-10-01

    The design of high-quality imaging lenses continues to strive for the best color trueness over wider and wider wavelength ranges such as for multiwavelength fluorescence microscopy or hyperspectral imaging. Glasses suitable for sharp images at more than two wavelengths must differ in their dispersion from the classical crown and flint glass types, which gather along a straight line in a plot of the relative partial dispersion against the Abbe number. Glasses suitable for multicolor correction can be recognized by a considerable deviation of their relative partial dispersion from this normal line. Originally, the normal lines for different relative partial dispersions were defined by using the SCHOTT glass types K7 and F2. Today's data sheets of all glass manufacturers contain numerical values for deviations of relative partial dispersions from the normal lines. A comparison of almost identical glasses shows differences between these deviations being too large, obviously coming from different versions of K7 and F2 dispersion curves used. For preselection in designs and for direct comparison of glass types, it is necessary to agree on common dispersion curves each for K7 and for F2 in order to obtain really comparable values for deviations of the relative partial dispersion from the normal line.

  16. Relation of eye dominancy with color vision discrimination performance ability in normal subjects

    Directory of Open Access Journals (Sweden)

    Belkıs Koçtekin

    2013-10-01

    Full Text Available AIM: To evaluate the performance of dominant eye (DE for color vision discrimination ability among the medical students with normal color vision.CONCLUSION: The color vision discrimination performance ability was found prominent for DE. This superiority was attributed to higher sensitivityof the r/g local color spectral region. We conclude that DE has priority in r/g color spectral region, probably including inhibition of NDE.

  17. HGF, MET, and matrix-related proteases in hepatocellular carcinoma, fibrolamellar variant, cirrhotic and normal liver.

    Science.gov (United States)

    Schoedel, Karen E; Tyner, Valerie Zajac; Kim, Tae-Hyoung; Michalopoulos, George K; Mars, Wendy M

    2003-01-01

    Fibrolamellar variant is an uncommon subcategory of hepatocellular carcinoma with a better prognostic outcome. Proteinases and growth factors that are involved in the remodeling of extracellular matrix may influence the behavior of cancers. To determine whether these factors contribute to the distinct etiologies of fibrolamellar hepatocellular carcinoma and traditional hepatocellular carcinoma, we assayed hepatocyte growth factor, the hepatocyte growth factor receptor, and two hepatocyte growth factor activators, hepatocyte growth factor activator and urokinase-type plasminogen activator, in hepatocellular carcinoma, fibrolamellar hepatocellular carcinoma, cirrhotic liver and normal liver. In addition, we examined the urokinase-type plasminogen activator receptor, the type 1 plasminogen activator inhibitor, plasmin, fibrinogen, and the type IV matrix metalloproteinases. Eighteen hepatocellular carcinomas and 11 fibrolamellar hepatocellular carcinomas were obtained as paraffin embedded sections from the University of Pittsburgh Department of Pathology. Frozen tissues from a subset of cases (9 hepatocellular carcinomas, 4 fibrolamellar hepatocellular carcinomas, 12 cirrhotic livers and 2 normal livers) were also available for analysis. Antibodies against urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor, hepatocyte growth factor and hepatocyte growth factor receptor were used to analyze immunoperoxidase stained slides from the paraffin blocks. Western blot analyses using antibodies against hepatocyte growth factor, hepatocyte growth factor receptor, phosphotyrosine, hepatocyte growth factor activator, urokinase-type plasminogen activator receptor, urokinase-type plasminogen activator, plasminogen activator inhibitor-1, fibrinogen and plasmin were performed on membrane-enriched fractions from the frozen tissue, as was collagen zymography for matrix metalloproteinase-2 and matrix metalloproteinase-9. The most notable findings are as

  18. Relating protein intake to nutritional status in haemodialysis patients : How to normalize the protein equivalent of total nitrogen appearance (PNA)?

    NARCIS (Netherlands)

    Kloppenburg, Wybe; Stegeman, CA; de Jong, PE; Huisman, RM

    1999-01-01

    Background. The protein equivalent of total nitrogen appearance (PNA) is assumed to be a reliable estimate of dietary protein intake in haemodialysis patients. Protein requirements are related to body size. In order to standardize PNA to individual differences in body size, PNA is normalized to vari

  19. Relating protein intake to nutritional status in haemodialysis patients : How to normalize the protein equivalent of total nitrogen appearance (PNA)?

    NARCIS (Netherlands)

    Kloppenburg, Wybe; Stegeman, CA; de Jong, PE; Huisman, RM

    1999-01-01

    Background. The protein equivalent of total nitrogen appearance (PNA) is assumed to be a reliable estimate of dietary protein intake in haemodialysis patients. Protein requirements are related to body size. In order to standardize PNA to individual differences in body size, PNA is normalized to vari

  20. Does Silent Reading Speed in Normal Adult Readers Depend on Early Visual Processes? Evidence from Event-Related Brain Potentials

    Science.gov (United States)

    Korinth, Sebastian Peter; Sommer, Werner; Breznitz, Zvia

    2012-01-01

    Little is known about the relationship of reading speed and early visual processes in normal readers. Here we examined the association of the early P1, N170 and late N1 component in visual event-related potentials (ERPs) with silent reading speed and a number of additional cognitive skills in a sample of 52 adult German readers utilizing a Lexical…

  1. 一种计算空间封闭曲面正侧法向量的方法%A Method to Calculate the Normal Vector of a Closed-Curve Surface

    Institute of Scientific and Technical Information of China (English)

    叶吉祥; 胡小兵

    2001-01-01

    In handling the surface of a 3D-ob ject with light,calculating the area of closed curve on the 3D-object and compu ting the volume of a 3D-object,the normal vector needs to be calculated.For this reason,this paper presents a brief and concise algorithm to calculate the norma lvector of 3D-object surfaces.%在三维物体表面光照处理、三维曲面上曲线 所围区域的计算以及三维物体体积计算等应用中,需要计算曲面正侧法向量。针对三角形网 格表示的空间封闭曲面,本文设计了一种计算曲面正侧法向量的简明算法。

  2. Pressure and velocity cross-spectrum of normal modes in low-frequency acoustic vector field of shallow water and its application

    Institute of Scientific and Technical Information of China (English)

    Yun Yu; Qing Ling,; Jiang Xu

    2015-01-01

    The pressure and horizontal particle velocity combined descriptions in the very low frequency acoustic field of shal ow wa-ter integrated with the concept of effective depth of Pekeris wave-guide is proposed, especial y the active component of the pressure and horizontal particle velocity cross-spectrum, also cal ed ho-rizontal complex cross acoustic intensity, when only two normal modes are trapped in the waveguide. Both the approximate theo-retic analysis and the numerical results show that the sign of the horizontal complex cross acoustic intensity active component is independent of the range when vertical y deployed receiving dual sensors are placed in appropriate depths, the sum of which is equal to the waveguide effective depth, so it can be used to tel whether the sound source is near the surface or underwater;while the range rate is expected to be measured by utilizing the sign distribution characteristic of the reactive component. The further robustness analysis of the depth classification algorithm shows that the existence of shear waves in semi infinite basement and the change of acoustic velocity profiles have few effects on the application of this method, and the seabed attenuation wil limit the detection range, but the algorithm stil has a good robustness in the valid detection range.

  3. Analysis of related factors affecting prognosis of shunt surgery in patients with secondary normal pressure hydrocephalus

    Directory of Open Access Journals (Sweden)

    WANG Cheng

    2013-08-01

    Full Text Available 【Abstract】Objective: The management of se-condary normal pressure hydrocephalus (sNPH is controversial. Many factors may affect the surgery effect. The purpose of this study was to identify the possible fac-tors influencing prognosis and provide theoretical basis for clinical treatment of sNPH. Methods: A retrospective study was carried out to investigate the results of 31 patients with sNPH who under-went ventriculoperitoneal shunt surgery from January 2007 to December 2011. We processed the potential influencing factors by univariate analysis and the result further by mul-tivariate logistic regression analysis. Results: Factors including age, disease duration and Glasgow coma scale (GCS score before surgery significantly influenced the prognosis of sNPH (P<0.05. Further logistic regression analysis showed that all the three factors are independent influencing factors. Conclusion: Age, disease duration and GCS score before surgery have positive predictive value in estimating favorable response to surgical treatment for sNPH. Key words: Hydrocephalus, normal pressure; Ventriculoperitoneal shunt; Regression analysis

  4. Vector grammars and PN machines

    Institute of Scientific and Technical Information of China (English)

    蒋昌俊

    1996-01-01

    The concept of vector grammars under the string semantic is introduced.The dass of vector grammars is given,which is similar to the dass of Chomsky grammars.The regular vector grammar is divided further.The strong and weak relation between the vector grammar and scalar grammar is discussed,so the spectrum system graph of scalar and vector grammars is made.The equivalent relation between the regular vector grammar and Petri nets (also called PN machine) is pointed.The hybrid PN machine is introduced,and its language is proved equivalent to the language of the context-free vector grammar.So the perfect relation structure between vector grammars and PN machines is formed.

  5. Vector analysis

    CERN Document Server

    Brand, Louis

    2006-01-01

    The use of vectors not only simplifies treatments of differential geometry, mechanics, hydrodynamics, and electrodynamics, but also makes mathematical and physical concepts more tangible and easy to grasp. This text for undergraduates was designed as a short introductory course to give students the tools of vector algebra and calculus, as well as a brief glimpse into these subjects' manifold applications. The applications are developed to the extent that the uses of the potential function, both scalar and vector, are fully illustrated. Moreover, the basic postulates of vector analysis are brou

  6. Normal versus anomalous self-diffusion in two-dimensional fluids: memory function approach and generalized asymptotic Einstein relation.

    Science.gov (United States)

    Shin, Hyun Kyung; Choi, Bongsik; Talkner, Peter; Lee, Eok Kyun

    2014-12-07

    Based on the generalized Langevin equation for the momentum of a Brownian particle a generalized asymptotic Einstein relation is derived. It agrees with the well-known Einstein relation in the case of normal diffusion but continues to hold for sub- and super-diffusive spreading of the Brownian particle's mean square displacement. The generalized asymptotic Einstein relation is used to analyze data obtained from molecular dynamics simulations of a two-dimensional soft disk fluid. We mainly concentrated on medium densities for which we found super-diffusive behavior of a tagged fluid particle. At higher densities a range of normal diffusion can be identified. The motion presumably changes to sub-diffusion for even higher densities.

  7. Reduced Specificity of Hippocampal and Posterior Ventrolateral Prefrontal Activity during Relational Retrieval in Normal Aging

    Science.gov (United States)

    Giovanello, Kelly S.; Schacter, Daniel L.

    2012-01-01

    Neuroimaging studies of episodic memory in young adults demonstrate greater functional neural activity in ventrolateral pFC and hippocampus during retrieval of relational information as compared with item information. We tested the hypothesis that healthy older adults--individuals who exhibit behavioral declines in relational memory--would show…

  8. Normal coordinate analysis and fungicidal activity study on anilazine and its related compound using spectroscopic techniques

    Science.gov (United States)

    Sheeja Mol, Gilbert Pushpam; Arul Dhas, Deva Dhas; Hubert Joe, Isaac; Balachandran, Sreedharan

    2016-06-01

    The FTIR and FT-Raman spectra of anilazine have been recorded in the range 400-4000 cm-1 and 50-3500 cm-1 respectively. The optimized geometrical parameters of the compound were calculated using B3LYP method with 6-311G(d,p) basis set. The distribution of the vibrational bands were carried out with the help of normal coordinate analysis (NCA). The 1H and 13C nuclear spectra have been recorded and chemical shifts of the molecule were also calculated using the gauge independent atomic orbital (GIAO) method. The UV-Visible spectrum of the compound was recorded in the region 190-900 nm and the electronic properties were determined by time-dependent DFT (TD-DFT) approach. Anilazine was screened for its antifungal activity. Molecular docking studies are conducted to predict its fungicidal activity.

  9. Analysis of related factors affecting prognosis of shunt surgery in patients with secondary normal pressure hydrocephalus

    Institute of Scientific and Technical Information of China (English)

    WANG Cheng; DU Hang-gen; YIN Li-chun; HE Min; ZHANG Guo-jun; TIAN Yong; HAO Bi-lie

    2013-01-01

    Objective:The management of secondary normal pressure hydrocephalus (sNPH) is controversial.Many factors may affect the surgery effect.The purpose of this study was to identify the possible factors influencing prognosis and provide theoretical basis for clinical treatment of sNPH.Methods:A retrospective study was carried out to investigate the results of 31 patients with sNPH who underwent ventriculoperitoneal shunt surgery from January 2007 to December 2011.We processed the potential influencing factors by univariate analysis and the result further by multivariate logistic regression analysis.Results:Factors including age,disease duration and Glasgow coma scale (GCS) score before surgery significantly influenced the prognosis of sNPH (P<0.05).Further logistic regression analysis showed that all the three factors are independent influencing factors.Conclusion:Age,disease duration and GCS score before surgery have positive predictive value in estimating favorable response to surgical treatment for sNPH.

  10. Intermodal timing relations and audio-visual speech recognition by normal-hearing adults.

    Science.gov (United States)

    McGrath, M; Summerfield, Q

    1985-02-01

    Audio-visual identification of sentences was measured as a function of audio delay in untrained observers with normal hearing; the soundtrack was replaced by rectangular pulses originally synchronized to the closing of the talker's vocal folds and then subjected to delay. When the soundtrack was delayed by 160 ms, identification scores were no better than when no acoustical information at all was provided. Delays of up to 80 ms had little effect on group-mean performance, but a separate analysis of a subgroup of better lipreaders showed a significant trend of reduced scores with increased delay in the range from 0-80 ms. A second experiment tested the interpretation that, although the main disruptive effect of the delay occurred on a syllabic time scale, better lipreaders might be attempting to use intermodal timing cues at a phonemic level. Normal-hearing observers determined whether a 120-Hz complex tone started before or after the opening of a pair of liplike Lissajou figures. Group-mean difference limens (70.7% correct DLs) were - 79 ms (sound leading) and + 138 ms (sound lagging), with no significant correlation between DLs and sentence lipreading scores. It was concluded that most observers, whether good lipreaders or not, possess insufficient sensitivity to intermodal timing cues in audio-visual speech for them to be used analogously to voice onset time in auditory speech perception. The results of both experiments imply that delays of up to about 40 ms introduced by signal-processing algorithms in aids to lipreading should not materially affect audio-visual speech understanding.

  11. Comparative analysis of gastrointestinal microbiota between normal and caudal-related homeobox 2 (cdx2) transgenic mice.

    Science.gov (United States)

    Sakamoto, Hirotsugu; Asahara, Takashi; Chonan, Osamu; Yuki, Norikatsu; Mutoh, Hiroyuki; Hayashi, Shunji; Yamamoto, Hironori; Sugano, Kentaro

    2015-01-01

    Caudal-related homeobox 2 (Cdx2) is expressed in the human intestinal metaplastic mucosa and induces intestinal metaplastic mucosa in the Cdx2 transgenic mouse stomach. Atrophic gastritis and intestinal metaplasia commonly lead to gastric achlorhydria, which predisposes the stomach to bacterial overgrowth. In the present study, we determined the differences in gut microbiota between normal and Cdx2 transgenic mice, using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Twelve normal (control) and 12 Cdx2 transgenic mice were sacrificed, and the gastric, jejunal, ileac, cecal and colonic mucosa, and feces were collected. To quantitate bacterial microbiota, we used real-time qRTPCR with 16S rRNA gene-targeted, species-specific primers. The total numbers of bacteria in the gastric, jejunal, ileac, cecal, and colonic mucosa of the Cdx2 transgenic mice were significantly higher than those of the normal mice. The Bacteroides fragilis group and also Prevotella were not detected in the stomach of the normal mice, although they were detected in the Cdx2 transgenic mice. Moreover, the Clostridium coccoides group, Clostridium leptum subgroup, Bacteroides fragilis group, and Prevotella were not detected in the jejunum or ileum of the normal mice, although they were detected in the Cdx2 transgenic mice. The fecal microbiota of the normal mice was similar to that of the Cdx2 transgenic mice. Our results showed the differences in composition of gut microbiota between normal and Cdx2 transgenic mice, which may be caused by the development of gastric achlorhydria and intestinal metaplasia in Cdx2 transgenic mice.

  12. Combining cluster analysis, feature selection and multiple support vector machine models for the identification of human ether-a-go-go related gene channel blocking compounds.

    Science.gov (United States)

    Nisius, Britta; Göller, Andreas H; Bajorath, Jürgen

    2009-01-01

    Blockade of the human ether-a-go-go related gene potassium channel is regarded as a major cause of drug toxicity and associated with severe cardiac side-effects. A variety of in silico models have been reported to aid in the identification of compounds blocking the human ether-a-go-go related gene channel. Herein, we present a classification approach for the detection of diverse human ether-a-go-go related gene blockers that combines cluster analysis of training data, feature selection and support vector machine learning. Compound learning sets are first divided into clusters of similar molecules. For each cluster, independent support vector machine models are generated utilizing preselected MACCS structural keys as descriptors. These models are combined to predict human ether-a-go-go related gene inhibition of our large compound data set with consistent experimental measurements (i.e. only patch clamp measurements on mammalian cell lines). Our combined support vector machine model achieves a prediction accuracy of 85% on this data set and performs better than alternative methods used for comparison. We also find that structural keys selected on the basis of statistical criteria are associated with molecular substructures implicated in human ether-a-go-go related gene channel binding.

  13. Mast Cells in Adjacent Normal Colon Mucosa rather than Those in Invasive Margin are Related to Progression of Colon Cancer

    Institute of Scientific and Technical Information of China (English)

    Qing Xia; Xiao-shi Zhang; Ying-bo Chen; Ya Ding; Xiao-jun Wu; Rui-qing Peng; Qiang Zhou; Jing Zeng; Jing-hui Hou; Xing Zhang; Yi-xin Zeng

    2011-01-01

    Objective:Mast cells (MC) reside in the mucosa of the digestive tract as the first line against bacteria and toxins.Clinical evidence has implied that the infiltration of mast cells in colorectal cancers is related to malignant phenotypes and a poor prognosis.This study compared the role of mast cells in adjacent normal colon mucosa and in the invasive margin during the progression of colon cancer.Methods:Specimens were obtained from 39 patients with colon adenomas and 155 patients with colon cancers treated at the Sun Yat-sen University Cancer Center between January 1999 and July 2004.The density of mast cells was scored by an immunohistochemical assay.The pattern of mast cell distribution and its relationship with dinicopathologic parameters and 5-year survival were analyzed.Results:The majority of mast cells were located in the adjacent normal colon mucosa,followed by the invasive margin and least in the cancer stroma.Mast cell count in adjacent normal colon mucosa (MCCadjacent) was associated with pathologic classification,distant metastases and hepatic metastases,although it was not a prognostic factor.In contrast,mast cell count in the invasive margin (MCCinvasive) was associated with neither the clinicopathlogic parameters nor overall survival.Conclusion:Mast cells in the adjacent normal colon mucosa were related to the progression of colon cancer,suggesting that mast cells might modulate tumor progression via a long-distance mechanism.

  14. Beyond Normal Competencies: Understanding Organisation Designs to Develop and Sustain IT-Related Capabilities

    Directory of Open Access Journals (Sweden)

    Acklesh Prasad

    2013-03-01

    Full Text Available It is apparent that IT resources are important for organisations. It is also clear that organisations unique competencies, their IT-related capabilities, leverage the IT resources uniquely to create and sustain competitive advantage. However, IT resources are dynamic, and evolve at an exponential rate. This means that organisations will need to sustain their competencies to leverage opportunities offered by new IT resources. Research on ways to sustain IT-related capabilities is limited and a deeper understanding of this situation is important. Amongst other factors, a possible reason for this lack of progress in this area could be due to the lack of validated measurement items of the theoretical constructs to conduct such studies. We suggest an environment in which organisations could build new and sustain their existing IT-related capabilities. We then report on the development of valid and reliable measures for this environment. The validated measures would be useful in extending our understanding on how firms could sustain their IT-related capabilities. This effort will provide a deeper understanding of how firms can secure sustainable IT-related business value from their acquired IT resources.

  15. Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    or meromorphic (allowing poles as singularities) functions. There already exists a well-developed theory for iterative holomorphic dynamical systems, and successful relations found between iteration theory and flows of vector fields have been one of the main motivations for the recent interest in holomorphic...... vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...... of parameter spaces into structurally stable domains, and a description of the bifurcations. For this reason, the talk will focus on these questions for complex polynomial vector fields....

  16. Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    The two branches of dynamical systems, continuous and discrete, correspond to the study of differential equations (vector fields) and iteration of mappings respectively. In holomorphic dynamics, the systems studied are restricted to those described by holomorphic (complex analytic) functions...... or meromorphic (allowing poles as singularities) functions. There already exists a well-developed theory for iterative holomorphic dynamical systems, and successful relations found between iteration theory and flows of vector fields have been one of the main motivations for the recent interest in holomorphic...... vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...

  17. Birth weight relates to blood pressure and microvascular function in normal subjects

    NARCIS (Netherlands)

    Serne, EH; Stehouwer, CDA; ter Maaten, JC; ter Wee, PM; Gans, ROB

    2000-01-01

    Objective The relationship between low birth weight and elevated blood pressure in adult life is well established but presently unexplained. Both microvascular dysfunction and insulin resistance have been proposed as a possible explanation. We have examined the relation between birth weight and bloo

  18. Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy

    NARCIS (Netherlands)

    Velzing-Aarts, Francien V; Holm, Pål I; Fokkema, M Rebecca; van der Dijs, Fey P; Ueland, Per M; Muskiet, Frits A

    2005-01-01

    Background: Plasma concentrations of total homocysteine (tHcy) decrease during pregnancy. This reduction has been investigated in relation to folate status, but no study has addressed the possible role of betaine and its precursor choline. Objective: We investigated the courses of plasma choline and

  19. Comparative Analysis of Gastrointestinal Microbiota Between Normal and Caudal-Related Homeobox 2 (Cdx2) Transgenic Mice

    OpenAIRE

    Sakamoto, Hirotsugu; Asahara, Takashi; Chonan, Osamu; Yuki, Norikatsu; Mutoh, Hiroyuki; Hayashi, Shunji; Yamamoto, Hironori; Sugano, Kentaro

    2015-01-01

    Background/Aims Caudal-related homeobox 2 (Cdx2) is expressed in the human intestinal metaplastic mucosa and induces intestinal metaplastic mucosa in the Cdx2 transgenic mouse stomach. Atrophic gastritis and intestinal metaplasia commonly lead to gastric achlorhydria, which predisposes the stomach to bacterial overgrowth. In the present study, we determined the differences in gut microbiota between normal and Cdx2 transgenic mice, using quantitative reverse transcription-polymerase chain reac...

  20. 速度向量成像评价正常成人右心室应变和应变率%Quantitative analysis of strain and strain rate of right ventricular in normal subjects by velocity vector imaging

    Institute of Scientific and Technical Information of China (English)

    侯海军; 智光; 张晓娟; 周肖; 徐勇

    2008-01-01

    目的 应用速度向量成像定量分析正常成人右室心肌应变和应变率.方法 选取健康成人32例,在心尖四腔观测量右室游离壁和室间隔右室面基底段、中间段、心尖段6个节段的应变和应变率收缩期峰值,Simpson法测量右室容量及射血分数.结果 Simpson法及速度向量成像法测量的正常右室射血分数高度相关(r=0.91,P<0.01),右室游离壁基底段和中间段的应变、应变率均高于心尖段(P<0.05).二者的应变和应变率差异均无统计学意义(P>0.05),室间隔右室面的应变和应变率也有相同的规律,右室游离壁基底段和中间段的应变和应变率高于相应室间隔节段(P<0.05),右室游离壁心尖段和室间隔心尖段的应变和应变率无明显差异,右室的应变和应变率和年龄无明显的相关性.结论 速度向量成像技术可以准确定量评估右室室壁应变和应变率.%Objective To investigate strain and strain rate of right ventricular(RV)based on twodimensional image by velocity vector imaging in normal subjects.Methods Thirty-two healthy adults were rolled in this study.Echocardiographic images in 4 chamber view were analyzed by conventional manual tracing for volumes and ejection fractions,which were also measured by velocity vector imaging.Myocardial velocity,strain rate,and strain were determined at the basal,mid,and apical segments of the RV free wall and ventricular septum by velocity vector imaging.Results RV ejection fractions obtained with manual tracing correlated strongly with the same indexes obtained by velocity vector imaging method in all subjects(r=0.91,P<0.01).The strain and strain rate value of middle segment and basal segment in RV free wall were higher than those of apical segment.There were same trend in ventricular septal.The strain and strain rate of middle segment and basal segment in RV free wall were higher than those of homologous segments in ventricular septal,but the indexes

  1. Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: relation to negative symptoms.

    Science.gov (United States)

    Sumiyoshi, Tomiki; Anil, A Elif; Jin, Dai; Jayathilake, Karu; Lee, Myung; Meltzer, Herbert Y

    2004-03-01

    Previous studies have suggested decreased N-methyl-D-aspartate (NMDA)-type glutamate receptor function may contribute to increased negative symptoms in patients with schizophrenia. Consistent with this hypothesis, glycine, a co-agonist at NMDA receptors, has been reported to improve negative symptoms associated with the illness. This study was performed to determine if plasma levels of glycine or its ratio to serine, a precursor of glycine, are decreased in patients with schizophrenia compared to normal control subjects or patients with major depression. We also tested the hypothesis that these amino acids were correlated with negative symptoms in subjects with schizophrenia. Plasma levels of glycine, serine, and their ratio, were compared in 144 patients with schizophrenia, 44 patients with major depression, and 49 normal control subjects. All subjects were medication-free. Psychopathology was evaluated using the Brief Psychiatric Rating Scale (BPRS). Plasma glycine levels and glycine/serine ratios were decreased in patients with schizophrenia relative to control subjects and patients with major depression. By contrast, serine levels were increased in patients with schizophrenia compared to normal subjects but not compared to major depression. Patients with major depression also had increased plasma serine levels and decreased glycine/serine ratios compared to normal controls, but glycine levels were not different from those of normal controls. In subjects with schizophrenia, glycine levels predicted the Withdrawal-Retardation score (BPRS), whereas no such correlation was found in subjects with major depression. These results provide additional evidence that decreased availability of glycine may be related to the pathophysiology of negative symptoms. The decreases in plasma glycine levels support the evidence for an abnormality in the glutamatergic system in schizophrenia, and provide additional support for efforts to improve negative symptoms by augmentation of

  2. Individuality Normalization when Labeling with Isotopic Glycan Hydrazide Tags (INLIGHT): A Novel Glycan-Relative Quantification Strategy

    Science.gov (United States)

    Walker, S. Hunter; Taylor, Amber D.; Muddiman, David C.

    2013-09-01

    The Individuality Normalization when Labeling with Isotopic Glycan Hydrazide Tags (INLIGHT) strategy for the sample preparation, data analysis, and relative quantification of N-linked glycans is presented. Glycans are derivatized with either natural (L) or stable-isotope labeled (H) hydrazide reagents and analyzed using reversed phase liquid chromatography coupled online to a Q Exactive mass spectrometer. A simple glycan ladder, maltodextrin, is first used to demonstrate the relative quantification strategy in samples with negligible analytical and biological variability. It is shown that after a molecular weight correction attributable to isotopic overlap and a post-acquisition normalization of the data to account for any systematic bias, a plot of the experimental H:L ratio versus the calculated H:L ratio exhibits a correlation of unity for maltodextrin samples mixed in different ratios. We also demonstrate that the INLIGHT approach can quantify species over four orders of magnitude in ion abundance. The INLIGHT strategy is further demonstrated in pooled human plasma, where it is shown that the post-acquisition normalization is more effective than using a single spiked-in internal standard. Finally, changes in glycosylation are able to be detected in complex biological matrices, when spiked with a glycoprotein. The ability to spike in a glycoprotein and detect change at the glycan level validates both the sample preparation and data analysis strategy, making INLIGHT an invaluable relative quantification strategy for the field of glycomics.

  3. Age-related normal ranges for the Haller index in children

    Energy Technology Data Exchange (ETDEWEB)

    Daunt, Stephen W.; Cohen, Justine H.; Miller, Stephen F. [Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 (Canada)

    2004-04-01

    The Haller index is an accepted CT method for evaluating thoracic dimensions in patients with pectus excavatum. The purpose of this study is to establish age- and gender-related norms for the Haller index in childhood. We retrospectively reviewed 574 consecutive chest CT examinations (M=285, F=289) performed at our institution from August 2001 through March 2002. Seventeen patients with a history of chest-wall deformity, trauma, or syndrome were excluded, for a total sample size of 557 patients. The Haller index was calculated for each patient, using electronic calipers. The sample population was then separated by gender and placed into 2-year age groupings. Two-way analysis of variance and Tukey's multiple comparisons were performed to determine significance at a=0.05. The least-square mean Haller index values for each age group and gender were calculated with 95% confidence intervals. In both males and females, the 0- to 2-year age group showed a significantly smaller mean Haller index than older children. In addition, females had significantly greater Haller index values than males in the 0- to 6- and 12- to 18-year age groups. The Haller index, a quantitative measurement of chest-wall configuration, demonstrates significant age- and gender-related variability. This should be considered when evaluating the patient with suspected chest-wall deformity. (orig.)

  4. Cloning vector

    Science.gov (United States)

    Guilfoyle, R.A.; Smith, L.M.

    1994-12-27

    A vector comprising a filamentous phage sequence containing a first copy of filamentous phage gene X and other sequences necessary for the phage to propagate is disclosed. The vector also contains a second copy of filamentous phage gene X downstream from a promoter capable of promoting transcription in a bacterial host. In a preferred form of the present invention, the filamentous phage is M13 and the vector additionally includes a restriction endonuclease site located in such a manner as to substantially inactivate the second gene X when a DNA sequence is inserted into the restriction site. 2 figures.

  5. Cloning vector

    Science.gov (United States)

    Guilfoyle, Richard A.; Smith, Lloyd M.

    1994-01-01

    A vector comprising a filamentous phage sequence containing a first copy of filamentous phage gene X and other sequences necessary for the phage to propagate is disclosed. The vector also contains a second copy of filamentous phage gene X downstream from a promoter capable of promoting transcription in a bacterial host. In a preferred form of the present invention, the filamentous phage is M13 and the vector additionally includes a restriction endonuclease site located in such a manner as to substantially inactivate the second gene X when a DNA sequence is inserted into the restriction site.

  6. Tumor-related markers in histologically normal margins correlate with locally recurrent oral squamous cell carcinoma: a retrospective study.

    Science.gov (United States)

    Wang, Xinhong; Chen, Si; Chen, Xinming; Zhang, Cuicui; Liang, Xueyi

    2016-02-01

    Oral squamous cell carcinoma (OSCC) is characterized by a high rate of local recurrence (LR) even when the surgical margins are considered histopathologically 'normal'. The aim of our study was to determine the relationship between early tumor-related markers detected in histologically normal margins (HNM) and LR as well as disease-free survival in OSCC. The loss of heterozygosity (LOH) of markers on 9p21 (D9s1747, RPS6, D9s162) and 17p13 (TP53) and the immunostaining results of the corresponding mutant P53, P14, P15, and P16 proteins were assessed and correlated with LR and disease-free survival in 71 OSCC patients who had HNM. Fifteen of 71 patients with HNM developed LR. The presence of the following molecular markers in surgical margins was significantly correlated with the development of LR: LOH on chromosome 9p21 (D9s1747 + RPS6 + D9s162), any LOH, P16, and P53 (chi-square test, P tumor-related markers in histologically 'normal' resection margins may be a useful method for assessing LR in OSCC patients. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. Melnikov-type Vectors and Principal Normals

    Institute of Scientific and Technical Information of China (English)

    朱德明

    1994-01-01

    The exponential dichotomy and the theory of transversality are used to give the condition and its geometric significance for the persistence of a singular orbit with higher degeneracy under small autonomous perturbations. Examples of the uniquely persisting singular orbits situated on a 2-dimensional cylinder (resp. torus) consisting of heteroclinic (resp. homoclinic) orbits are also given.

  8. Age-related changes of the multidrug resistance P-glycoprotein function in normal human peripheral blood T lymphocytes

    Directory of Open Access Journals (Sweden)

    C.G. Machado

    2003-12-01

    Full Text Available The multidrug resistance P-glycoprotein is a transmembrane efflux pump expressed by lymphocytes and is involved in their cytolytic activity. In the present study, we investigated the age-related changes of P-glycoprotein function in normal peripheral blood lymphocytes. Blood samples from 90 normal volunteers (age range, 0 to 86 years were analyzed. P-glycoprotein function was assessed by the flow cytometric rhodamine 123 assay. P-glycoprotein function was highest in cord blood and progressively declined with age in peripheral blood T CD4+ and CD8+ cells. In contrast, P-glycoprotein function did not vary with age in CD19+ B or CD16+CD56+ natural killer cells. These data suggest that the decline in P-glycoprotein function in T CD4+ and CD8+ lymphocytes as a function of age may contribute to the decrease in T cell cytolytic activity with aging.

  9. (99m)Tc-DMSA absolute and relative renal uptake in cats: procedure and normal values.

    Science.gov (United States)

    Vandermeulen, Eva; Ham, Hamphrey R; Dobbeleir, André A; De Sadeleer, Carlos; Piepsz, Amy; Waelbers, Tim; Vermeire, Simon T; Slegers, Guido; Peremans, Kathelijne Y

    2011-06-01

    In this study we investigated the influence of technical factors (positioning, background (BG) correction and attenuation correction) on qualitative and quantitative (absolute (AU) and relative (RU) uptake) assessment of feline kidneys with (99m)technetium labelled dimercaptosuccinic acid ((99m)Tc-DMSA). Eleven healthy adult cats were included. Influence of BG and depth correction on quantitative assessment was evaluated. Depth correction was based on the geometric mean method (using dorsal and ventral images) and the use of two standards placed over each individual kidney. Visual evaluation showed superiority of dorsal and ventral over lateral positioning due to increased separation of the kidneys permitting region of interest (ROI) placement without overlap. No apparent influence of BG correction was found for RU. However, AU was systematically overestimated without BG correction. Depth correction did not seem to affect RU in most cases, however, in some cats the differences were not negligible. The values for AU without depth correction were lower compared to depth corrected values.

  10. Expression of androgen and estrogen related proteins in normal weight and obese prostate cancer patients.

    Science.gov (United States)

    Gross, Mitchell; Ramirez, Cristina; Luthringer, Daniel; Nepomuceno, Edward; Vollmer, Robin; Burchette, James; Freedland, Stephen J

    2009-04-01

    Obesity is associated with an aggressive form of prostate cancer and with alterations in androgen and estrogen metabolism. We hypothesized that changes in components of the sex steroid receptor axis may contribute to the clinical aggressiveness of prostate cancer in obese patients. A database was assembled containing clinical and pathological variables from 539 patients treated with radical prostatectomy at a single urban hospital between 1994 and 2002. Tissue microarrays were constructed from representative patients and expression of androgen receptor (AR), PSA, estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), and aromatase was examined. Higher BMI correlated strongly with black race, the presence of extra-capsular extension, and higher pathologic stage. Expression of AR, PSA, ERbeta and aromatase in cancerous epithelial cells did not differ according to obesity status. However, decreased expression of ERalpha and aromatase was observed in the stromal compartment surrounding non-cancerous acini in obese patients. We confirm the previously reported associations between obesity and aggressive clinical and pathologic features in our single-institution, urban teaching hospital. In comparing obese versus non-obese patients, there was no difference in expression of androgen or estrogen related proteins in cancerous epithelial cells. However, there was a down-regulation of ERalpha and aromatase in the stroma of obese patients. Our data suggest obesity may cause stromal changes in the sex steroid production and signaling pathways which may affect prostate cancer growth via intracrine/paracrine mechanisms. (c) 2008 Wiley-Liss, Inc.

  11. A Bayesian threshold-normal mixture model for analysis of a continuous mastitis-related trait.

    Science.gov (United States)

    Ødegård, J; Madsen, P; Gianola, D; Klemetsdal, G; Jensen, J; Heringstad, B; Korsgaard, I R

    2005-07-01

    Mastitis is associated with elevated somatic cell count in milk, inducing a positive correlation between milk somatic cell score (SCS) and the absence or presence of the disease. In most countries, selection against mastitis has focused on selecting parents with genetic evaluations that have low SCS. Univariate or multivariate mixed linear models have been used for statistical description of SCS. However, an observation of SCS can be regarded as drawn from a 2- (or more) component mixture defined by the (usually) unknown health status of a cow at the test-day on which SCS is recorded. A hierarchical 2-component mixture model was developed, assuming that the health status affecting the recorded test-day SCS is completely specified by an underlying liability variable. Based on the observed SCS, inferences can be drawn about disease status and parameters of both SCS and liability to mastitis. The prior probability of putative mastitis was allowed to vary between subgroups (e.g., herds, families), by specifying fixed and random effects affecting both SCS and liability. Using simulation, it was found that a Bayesian model fitted to the data yielded parameter estimates close to their true values. The model provides selection criteria that are more appealing than selection for lower SCS. The proposed model can be extended to handle a wide range of problems related to genetic analyses of mixture traits.

  12. Age-related normal uptake of {sup 99m}Tc-MDP in the lower spine

    Energy Technology Data Exchange (ETDEWEB)

    Sundkvist, G.M.G. [Dept. of Clinical Physiology, Centralsjukhuset, Kristianstad (Sweden); Lilja, B. [Dept. of Clinical Physiology, Universitetssjukhuset MAS, Malmoe (Sweden); Mattsson, S. [Dept. of Radiation Physics, Universitetssjukhuset MAS, Malmoe (Sweden)

    1997-03-01

    Aim: The uptake of {sup 99m}Tc-MDP in the lower spine was quantified in connection with ordinary bone scintigraphy. Methods: Fifty-seven women and seventy-two men (aged 20-69 y), with no signs of metabolic or malignant disease and no history of back pain or atraumatic fractures, were included in the study. Results: The women showed an increase in {sup 99m}Tc-MDP uptake from the age of 20 y to about 45 y with a decrease from the time of menopause. In contrast to women, the uptake in men showed a slight decrease from the age of 20 y to about 50 y and thereafter a more marked decrease was seen. The major difference between men and women is the high premenopausal uptake in the female skeleton. Conclusion: An understanding of age-related changes in {sup 99m}Tc-MDP uptake, which are indices of the skeletal metabolism, is of importance especially in prevention and treatment of osteoporosis, a common disorder in postmenopausal women. (orig.) [Deutsch] Ziel: In Verbindung mit einer routinemaessigen Skelettszintigraphie wurde die Speicherung von {sup 99m}Tc-MDP in der unteren Wirbelsaeule quantifiziert. Methoden: 57 Frauen und 22 Maenner (Alter von 20-69 Jahren) ohne metabolische oder boesartige Erkrankungen sowie ohne Rueckenschmerzen oder Wirbelsinterungen wurden in die Studien aufgenommen. Ergebnisse: Bei Frauen zeigte sich ein Anstieg der {sup 99m}Tc-MDP-Speicherung zwischen den Altersabschnitten 20 bis 45 Jahre und dann ein Abfall waehrend der Menopause. Im Gegensatz hierzu zeigte sich bei Maennern ein leichter Abfall der Speicherung vom 20. bis 50. Lebensjahr und danach eine noch staerkere Abnahme. Der Hauptunterschied zwischen den Geschlechtern ist die relativ hohe Speicherung im weiblichen Skelett praemenopausal. Schlussfolgerung: Das Verstaendnis der Altersbeziehungen der {sup 99m}Tc-MDP-Speicherung als Indikator des Knochenstoffwechsels ist fuer Praevention und Behandlung der postmenopausalen Osteoporose wichtig. (orig.)

  13. Insecticide resistance in the dengue vector Aedes aegypti from Martinique: distribution, mechanisms and relations with environmental factors.

    Directory of Open Access Journals (Sweden)

    Sébastien Marcombe

    Full Text Available Dengue is an important mosquito borne viral disease in Martinique Island (French West Indies. The viruses responsible for dengue are transmitted by Aedes aegypti, an indoor day-biting mosquito. The most effective proven method for disease prevention has been by vector control by various chemical or biological means. Unfortunately insecticide resistance has already been observed on the Island and recently showed to significantly reduce the efficacy of vector control interventions. In this study, we investigated the distribution of resistance and the underlying mechanisms in nine Ae. aegypti populations. Statistical multifactorial approach was used to investigate the correlations between insecticide resistance levels, associated mechanisms and environmental factors characterizing the mosquito populations. Bioassays revealed high levels of resistance to temephos and deltamethrin and susceptibility to Bti in the 9 populations tested. Biochemical assays showed elevated detoxification enzyme activities of monooxygenases, carboxylesterases and glutathione S-tranferases in most of the populations. Molecular screening for common insecticide target-site mutations, revealed the presence of the "knock-down resistance" V1016I Kdr mutation at high frequency (>87%. Real time quantitative RT-PCR showed the potential involvement of several candidate detoxification genes in insecticide resistance. Principal Component Analysis (PCA performed with variables characterizing Ae. aegypti from Martinique permitted to underline potential links existing between resistance distribution and other variables such as agriculture practices, vector control interventions and urbanization. Insecticide resistance is widespread but not homogeneously distributed across Martinique. The influence of environmental and operational factors on the evolution of the resistance and mechanisms are discussed.

  14. Semitopological Vector Spaces and Hyperseminorms

    Directory of Open Access Journals (Sweden)

    Mark Burgin

    2013-11-01

    Full Text Available In this paper, we introduce and study semitopological vector spaces. The goal is to provide an efficient base for developing the theory of extrafunction spaces in an abstract setting of algebraic systems and topological spaces. Semitopological vector spaces are more general than conventional topological vector spaces, which proved to be very useful for solving many problems in functional analysis. To study semitopological vector spaces, hypermetrics and hyperpseudometrics are introduced and it is demonstrated that hyperseminorms, studied in previous works of the author, induce hyperpseudometrics, while hypernorms induce hypermetrics. Sufficient and necessary conditions for a hyperpseudometric (hypermetric to be induced by a hyperseminorm (hypernorm are found. We also show that semitopological vector spaces are closely related to systems of hyperseminorms. Then defining boundedness and continuity relative to associated systems of hyperseminorms, we study relations between relative boundedness and relative continuity for mappings of vector spaces with systems of hyperseminorms and systems of hypernorms.

  15. Normalization in econometrics

    OpenAIRE

    Hamilton, James D.; Daniel F. Waggoner; Zha, Tao

    2004-01-01

    The issue of normalization arises whenever two different values for a vector of unknown parameters imply the identical economic model. A normalization does not just imply a rule for selecting which point, among equivalent ones, to call the maximum likelihood estimator (MLE). It also governs the topography of the set of points that go into a small-sample confidence interval associated with that MLE. A poor normalization can lead to multimodal distributions, disjoint confidence intervals, and v...

  16. Seasonal patterns for entomological measures of risk for exposure to Culex vectors and West Nile virus in relation to human disease cases in northeastern Colorado.

    Science.gov (United States)

    Bolling, Bethany G; Barker, Christopher M; Moore, Chester G; Pape, W John; Eisen, Lars

    2009-11-01

    We examined seasonal patterns for entomological measures of risk for exposure to Culex vectors and West Nile virus (family Flaviviridae, genus Flavivirus, WNV) in relation to human WNV disease cases in a five-county area of northeastern Colorado during 2006-2007. Studies along habitat/elevation gradients in 2006 showed that the seasonal activity period is shortened and peak numbers occur later in the summer for Culex tarsalis Coquillett females in foothills-montane areas >1600 m compared with plains areas Studies in the plains of northeastern Colorado in 2007 showed that seasonal patterns of abundance for Cx. tarsalis and Culex pipiens L. females differed in that Cx. tarsalis reached peak abundance in early July (mean of 328.9 females per trap night for 18 plains sites), whereas the peak for Cx. pipiens did not occur until late August (mean of 16.4 females per trap night). During June-September in 2007, which was a year of intense WNV activity in Colorado with 578 reported WNV disease cases, we recorded WNV-infected Cx. tarsalis females from 16 of 18 sites in the plains. WNV infection rates in Cx. tarsalis females increased gradually from late June to peak in mid-August (overall maximum likelihood estimate for WNV infection rate of 8.29 per 1000 females for the plains sites in mid-August). No WNV-infected Culex mosquitoes were recorded from sites >1600 m. The vector index for abundance of WNV-infected Cx. tarsalis females for the plains sites combined exceeded 0.50 from mid-July to mid-August, with at least one site exceeding 1.00 from early July to late August. Finally, we found that abundance of Cx. tarsalis females and the vector index for infected females were strongly associated with weekly numbers of WNV disease cases with onset 4-7 wk later (female abundance) or 1-2 wk later (vector index).

  17. 速度向量成像技术对正常胎儿左室心肌纵向运动功能的分析%Evaluation of Left Ventricular Myocardial Longitudinal Function in Normal Fetus by Velocity Vector Imaging

    Institute of Scientific and Technical Information of China (English)

    张雪梅; 李锐; 郭燕丽; 张晓航; 段灵敏; 薛雅方; 唐春霖

    2011-01-01

    Objective To evaluate the left ventricular myocardial longitudinal function in normal fetus by velocity vector imaging (VVI). Methods The standard four-chamber views in 50 normal fetus were collected using VVI mode. The regional tissue velocity, strain, and strain rate of the interventricular septum and left lateral wall were measured using VVI sofeware. Results Left ventriculor myocardial longitudinal funtion in 45 Fetus were evaluated by,Tissue velocity decreased gradually from the basal segment to the apical segment, strain and strain rate were no significant differences among 6 segments. Conclusions VVI was a new technique for analysing myocardial function. left ventricular myocardial longitudinal function can be evaluated in normal fetus.%目的 探讨速度向量成像技术分析正常胎儿左室纵向心肌运动功能的方法,分析正常胎儿左室纵向心肌运动的特征.方法 采用Sequeia 512超声诊断仪,在速度向量成像技术模式下对50例正常胎儿心脏取标准四腔心切面,分析左室侧壁及室间隔基底段、中间段、心尖段节段心肌运动速度、应变及应变率.结果 50例胎儿中45例成功获得速度向量成像技术图像,速度向量成像技术获得左室6个节段心肌任意时间的运动速度、应变及应变率彩色图、曲线及三维图像.左室6个节段心肌运动速度由基底段向心尖段呈递减趋势,心肌应变及应变率无基底段向心尖段递减的分布趋势.结论 速度向量成像技术无角度依赖性,是分析胎儿心肌运动的新技术,可测量节段心肌运动速度、应变及应变率,可用于胎儿心脏左室纵向心肌运动的分析.

  18. Vector geometry

    CERN Document Server

    Robinson, Gilbert de B

    2011-01-01

    This brief undergraduate-level text by a prominent Cambridge-educated mathematician explores the relationship between algebra and geometry. An elementary course in plane geometry is the sole requirement for Gilbert de B. Robinson's text, which is the result of several years of teaching and learning the most effective methods from discussions with students. Topics include lines and planes, determinants and linear equations, matrices, groups and linear transformations, and vectors and vector spaces. Additional subjects range from conics and quadrics to homogeneous coordinates and projective geom

  19. Relative Abundance and Plasmodium Infection Rates of Malaria Vectors in and around Jabalpur, a Malaria Endemic Region in Madhya Pradesh State, Central India.

    Directory of Open Access Journals (Sweden)

    Neeru Singh

    Full Text Available This study was undertaken in two Primary Health Centers (PHCs of malaria endemic district Jabalpur in Madhya Pradesh (Central India.In this study we had investigated the relative frequencies of the different anopheline species collected within the study areas by using indoor resting catches, CDC light trap and human landing methods. Sibling species of malaria vectors were identified by cytogenetic and molecular techniques. The role of each vector and its sibling species in the transmission of the different Plasmodium species was ascertained by using sporozoite ELISA.A total of 52,857 specimens comprising of 17 anopheline species were collected by three different methods (39,964 by indoor resting collections, 1059 by human landing and 11,834 by CDC light trap. Anopheles culicifacies was most predominant species in all collections (55, 71 and 32% in indoor resting, human landing and light trap collections respectively followed by An. subpictus and An. annularis. All five sibling species of An. culicifacies viz. species A, B, C, D and E were found while only species T and S of An. fluviatilis were collected. The overall sporozoite rate in An. culicifacies and An. fluviatilis were 0.42% (0.25% for P. falciparum and 0.17% for P. vivax and 0.90% (0.45% for P. falciparum and 0.45% for P. vivax respectively. An. culicifacies and An. fluviatilis were found harbouring both P. vivax variants VK-210 and VK-247, and P. falciparum. An. culicifacies sibling species C and D were incriminated as vectors during most part of the year while sibling species T of An. fluviatilis was identified as potential vector in monsoon and post monsoon season.An. culicifacies species C (59% was the most abundant species followed by An. culicifacies D (24%, B (8.7%, E (6.7% and A (1.5%. Among An. fluviatilis sibling species, species T was common (99% and only few specimens of S were found. Our study provides crucial information on the prevalence of An. culicifacies and An

  20. Human Behavior Classification Using Multi-Class Relevance Vector Machine

    Directory of Open Access Journals (Sweden)

    Yogameena, B.

    2010-01-01

    Full Text Available Problem statement: In computer vision and robotics, one of the typical tasks is to identify specific objects in an image and to determine each object’s position and orientation relative to coordinate system. This study presented a Multi-class Relevance Vector machine (RVM classification algorithm which classifies different human poses from a single stationary camera for video surveillance applications. Approach: First the foreground blobs and their edges are obtained. Then the relevance vector machine classification scheme classified the normal and abnormal behavior. Results: The performance proposed by our method was compared with Support Vector Machine (SVM and multi-class support vector machine. Experimental results showed the effectiveness of the method. Conclusion: It is evident that RVM has good accuracy and lesser computational than SVM.

  1. Statokinesigram normalization method.

    Science.gov (United States)

    de Oliveira, José Magalhães

    2017-02-01

    Stabilometry is a technique that aims to study the body sway of human subjects, employing a force platform. The signal obtained from this technique refers to the position of the foot base ground-reaction vector, known as the center of pressure (CoP). The parameters calculated from the signal are used to quantify the displacement of the CoP over time; there is a large variability, both between and within subjects, which prevents the definition of normative values. The intersubject variability is related to differences between subjects in terms of their anthropometry, in conjunction with their muscle activation patterns (biomechanics); and the intrasubject variability can be caused by a learning effect or fatigue. Age and foot placement on the platform are also known to influence variability. Normalization is the main method used to decrease this variability and to bring distributions of adjusted values into alignment. In 1996, O'Malley proposed three normalization techniques to eliminate the effect of age and anthropometric factors from temporal-distance parameters of gait. These techniques were adopted to normalize the stabilometric signal by some authors. This paper proposes a new method of normalization of stabilometric signals to be applied in balance studies. The method was applied to a data set collected in a previous study, and the results of normalized and nonnormalized signals were compared. The results showed that the new method, if used in a well-designed experiment, can eliminate undesirable correlations between the analyzed parameters and the subjects' characteristics and show only the experimental conditions' effects.

  2. Vector optimization set-valued and variational analysis

    CERN Document Server

    Chen, Guang-ya; Yang, Xiaogi

    2005-01-01

    This book is devoted to vector or multiple criteria approaches in optimization. Topics covered include: vector optimization, vector variational inequalities, vector variational principles, vector minmax inequalities and vector equilibrium problems. In particular, problems with variable ordering relations and set-valued mappings are treated. The nonlinear scalarization method is extensively used throughout the book to deal with various vector-related problems. The results presented are original and should be interesting to researchers and graduates in applied mathematics and operations research

  3. Relative toxicity of neem fruit, bitter gourd, and castor seed extracts against the larvae of filaria vector, Culex quinquefasciatus (Say).

    Science.gov (United States)

    Batabyal, Lata; Sharma, Preeti; Mohan, Lalit; Maurya, Prejwltta; Srivastava, C N

    2009-10-01

    In search of a natural larvicide, petroleum ether, carbon tetrachloride, and methanol extracts of Azadirachta indica fruits and seed extracts of bitter gourd (Momordica charantia) and castor (Ricinus communis) were tested for larvicidal activity against Culex quinquefasciatus. Among the extracts tested, the methanol extract of Az. indica was observed the most potent with LC(50) at 74.04 and 58.52 ppm and LC(-90) at 201.83 and 171.70 ppm as compared to methanol extract of M. charantia with LC(50) at 101.18 and 93.58 ppm and LC(90) at 322.81 and 302.62 ppm carbon tetrachloride extract of R. communis with LC(50) at 144.11 and 92.44 ppm and LC(90) at 432.42 and 352.89 ppm after 24 and 48 h, respectively. The methanol extract of Az. indica exhibited potential results and can be exploited as a preferred natural larvicide for the control of filarial vector, Cx. quinquefasciatus.

  4. Insomnia related to dysthymia: polysomnographic and psychometric comparison with normal controls and acute therapeutic trials with trazodone.

    Science.gov (United States)

    Saletu-Zyhlarz, G M; Abu-Bakr, M H; Anderer, P; Semler, B; Decker, K; Parapatics, S; Tschida, U; Winkler, A; Saletu, B

    2001-01-01

    Utilizing polysomnography (PSG) and psychometry, objective and subjective sleep and awakening quality was investigated in 11 patients (mean age 50 +/- 14) with nonorganic insomnia (F 51.0) related to dysthymia (F 34.1) as compared with 11 age- and sex-matched normal controls. Patients demonstrated decreased sleep efficiency and sleep stage S2 as well as increased sleep latency to S1, S2 and S3, wakefulness within the total sleep period, number of awakenings, S1 and REM sleep. There was no intergroup difference in REM latency. Subjective sleep quality and the total score of the Self-Assessment Scale for Sleep and Awakening Quality (SSA) were deteriorated as were evening and morning well-being, mood, affectivity and drowsiness. Noopsychic measures showed deteriorated numerical memory, fine motor activity and reaction time variability. In a placebo-controlled crossover design study, the acute effects of 100 mg trazodone, a serotonin reuptake inhibitor with a sedative action due to 5HT(2) and alpha(1) receptor blockade, were investigated in the patients. As compared with placebo, trazodone induced an increase in slow-wave sleep (S3 + 4), a lengthening of REM latency, a decrease in REM sleep and a normalization of the periodic leg movement (PLM) index. In the morning, there was a minimal increase in somatic complaints and a decrease in critical flicker frequency and systolic blood pressure. In conclusion, our study demonstrated that dysthymia induced significant changes in objective and subjective sleep and awakening quality, which were counteracted by 100 mg trazodone, thus suggesting a key-lock principle in the treatment of nonorganic insomnia related to dysthymia with this drug.

  5. mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits.

    Science.gov (United States)

    Yang, Fengying; Chu, Xiaolei; Yin, Miaomiao; Liu, Xiaolei; Yuan, Hairui; Niu, Yanmei; Fu, Li

    2014-05-01

    Defect of autophagy is common to many neurodegenerative disorders because it serves as a major degradation pathway for the clearance of various aggregate-prone proteins. Mammalian target of rapamycin (mTOR) signaling, which is recognized as the most important negative regulator of autophagy, is also involved in neurodegenerative diseases. However, the role of mTOR and its dependent autophagy in normal brain during aging remains unknown. Furthermore, caloric restriction (CR) is frequently used as a tool to study mechanisms behind aging and age-associated diseases because CR can prevent age-related diseases and prolong lifespan in several model organisms. Inhibiting mTOR and promoting autophagy activity play roles in aging delayed by CR. However, whether CR can ameliorate age-related cognition deficits by inhibiting mTOR and activate autophagy in hippocampus needs to be further investigated. Here we showed a decline of autophagic degradation in mice hippocampus in correlation with age-dependent cognitive dysfunction, whereas the activity of mTOR and its upstream brain-derived neurotrophic factor (BDNF)/phosphatidylinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling was decreased with aging. In addition, facilitating the mTOR pathway successfully declines and sustains autophagic degradation with aging in hippocampus by CR treatment and is involved in CR by ameliorating age-related cognitive deficits.

  6. Do Radio-loud Active Galactic Nuclei really follow the same MBH-σ* Relation as Normal Galaxies?

    Institute of Scientific and Technical Information of China (English)

    Yi Liu; Dong-Rong Jiang

    2006-01-01

    In an examination of the relationship between the black hole mass MBH and stellar velocity dispersion σ* in radio-loud active galactic nuclei (AGNs), we studied two effects which may cause uncertainties in the black hole mass estimates of radio-loud AGNs: the relativistic beaming effect on the observed optical continuum radiation and the orientation effect on the broad emission line width. After correcting these two effects, we re-examined the MBH-σ[OⅢ] relation for a sample of radio-loud and radio-quiet AGNs, and found the relation for radio-loud AGNs still deviated from that for nearby normal galaxies and radio-quiet AGNs. We also found there is no significant correlation between radio jet power and narrow [OⅢ] line width, indicating absence of strong interaction between radio jet and narrow line region. It may be that the deviation of the MBH- σ* relation of radio-loud AGNs is intrinsic,or that the [OⅢ] line width is not a good indicator of σ* for radio-loud AGNs.

  7. DNA sequence characterisation and phylogeography of Lymnaea cousini and related species, vectors of fascioliasis in northern Andean countries, with description of L. meridensis n. sp. (Gastropoda: Lymnaeidae

    Directory of Open Access Journals (Sweden)

    Bargues M Dolores

    2011-07-01

    Full Text Available Abstract Background Livestock fascioliasis is a problem throughout Ecuador, Colombia and Venezuela, mainly in Andean areas where the disease also appears to affect humans. Transmission patterns and epidemiological scenarios of liver fluke infection have shown to differ according to the lymnaeid vector snail species involved. These Andean countries present the vectors Lymnaea cousini, L. bogotensis and L. ubaquensis, unknown in the rest of Latin America. An exhaustive combined haplotype study of these species is performed by means of DNA sequencing of the nuclear ribosomal 18S RNA gene, ITS-2 and ITS-1, and mitochondrial DNA cox1 gene. Results The conserved 5.8S rDNA sequence corroborated that no pseudogenes are involved in the numerous non-microsatellite/minisatellite-related indels appearing between the ITS-2 and ITS-1 sequences when comparing different L. cousini - L. bogotensis populations. Sequence analyses and phylogenetic reconstruction methods including other lymnaeid vector species show that (i L. bogotensis is a synonym of L. cousini, (ii L. ubaquensis is a synonym of Pseudosuccinea columella, and (iii populations of L. cousini hitherto known from Venezuelan highlands indeed belong to a new species for which the name L. meridensis n. sp. is proposed. This new species is described and a complete phenotypic differentiation provided. Conclusions ITS-2, ITS-1 and cox1 prove to be good markers for specimen classification and haplotype characterisation of these morphologically similar lymnaeids in endemic areas. Analysis of the 18S gene and phylogenetic reconstructions indicate that L. cousini and L. meridensis n. sp. cluster in an evolutionary line different from the one of P. columella, despite their external resemblance. This suggests an evolutionary phenotypic convergence related to similar environments and which has given rise to frequent specimen misclassification. Body size and phylogenetic relationships of L. meridensis n. sp. with

  8. Canine Recombinant Adenovirus Vector Induces an Immunogenicity-Related Gene Expression Profile in Skin-Migrated CD11b+ -Type DCs

    Science.gov (United States)

    Jouneau, Luc; Bourge, Mickael; Bouet-Cararo, Coraline; Bonneau, Michel; Zientara, Stephan; Klonjkowski, Bernard; Schwartz-Cornil, Isabelle

    2012-01-01

    Gene expression profiling of the blood cell response induced early after vaccination has previously been demonstrated to predict the immunogenicity of vaccines. In this study, we evaluated whether the analysis of the gene expression profile of skin-migrated dendritic cells (DCs) could be informative for the in vitro prediction of immunogenicity of vaccine, using canine adenovirus serotype 2 (CAV2) as vaccine vector. CAV2 has been shown to induce immunity to transgenes in several species including sheep and is an interesting alternative to human adenovirus-based vectors, based on the safety records of the parental strain in dogs and the lack of pre-existing immunity in non-host species. Skin-migrated DCs were collected from pseudo-afferent lymph in sheep. Both the CD11b+ -type and CD103+ -type skin-migrated DCs were transduced by CAV2. An analysis of the global gene response to CAV2 in the two skin DC subsets showed that the gene response in CD11b+ -type DCs was far higher and broader than in the CD103+ -type DCs. A newly released integrative analytic tool from Ingenuity systems revealed that the CAV2-modulated genes in the CD11b+ -type DCs clustered in several activated immunogenicity-related functions, such as immune response, immune cell trafficking and inflammation. Thus gene profiling in skin-migrated DC in vitro indicates that the CD11b+ DC type is more responsive to CAV2 than the CD103+ DC type, and provides valuable information to help in evaluating and possibly improving viral vector vaccine effectiveness. PMID:23300693

  9. Canine recombinant adenovirus vector induces an immunogenicity-related gene expression profile in skin-migrated CD11b⁺ -type DCs.

    Directory of Open Access Journals (Sweden)

    Vanessa Contreras

    Full Text Available Gene expression profiling of the blood cell response induced early after vaccination has previously been demonstrated to predict the immunogenicity of vaccines. In this study, we evaluated whether the analysis of the gene expression profile of skin-migrated dendritic cells (DCs could be informative for the in vitro prediction of immunogenicity of vaccine, using canine adenovirus serotype 2 (CAV2 as vaccine vector. CAV2 has been shown to induce immunity to transgenes in several species including sheep and is an interesting alternative to human adenovirus-based vectors, based on the safety records of the parental strain in dogs and the lack of pre-existing immunity in non-host species. Skin-migrated DCs were collected from pseudo-afferent lymph in sheep. Both the CD11b(+ -type and CD103(+ -type skin-migrated DCs were transduced by CAV2. An analysis of the global gene response to CAV2 in the two skin DC subsets showed that the gene response in CD11b(+ -type DCs was far higher and broader than in the CD103(+ -type DCs. A newly released integrative analytic tool from Ingenuity systems revealed that the CAV2-modulated genes in the CD11b(+ -type DCs clustered in several activated immunogenicity-related functions, such as immune response, immune cell trafficking and inflammation. Thus gene profiling in skin-migrated DC in vitro indicates that the CD11b(+ DC type is more responsive to CAV2 than the CD103(+ DC type, and provides valuable information to help in evaluating and possibly improving viral vector vaccine effectiveness.

  10. Knowledge, attitudes and preventive behaviors related to dengue vector breeding control measures among adults in communities of Vientiane, capital of the Lao PDR.

    Science.gov (United States)

    Sayavong, Chanthalay; Chompikul, Jiraporn; Wongsawass, Somsak; Rattanapan, Cheerwit

    2015-01-01

    This research aimed to determine the knowledge, attitudes and preventive behaviors (KAP) of adults in relation to dengue vector control measures in the communities of Vientiane, the capital of the Lao PDR. A total of 207 respondents were actively participating in this cross-sectional descriptive study in 2011. Representatives of households were interviewed face-to-face by six trained interviewers using a structured questionnaire. KAP reliabilities of 0.89, 0.91 and 0.95 were reported in the pilot sample of 30 cases. The associations between each independent variable and prevention behavior were tested with chi-square tests. Multiple logistic regression was used to determine the factors that were significantly associated with preventive behavior while controlling for the other variables. The results revealed that 51.69% of the respondents had a high level of knowledge. More than 94% of the respondents knew that dengue fever is a dangerous communicable disease and that dengue fever is transmitted from person to person via mosquitoes. More than half (56.52%) of the participants had positive attitudes toward vector control measures, and 52.17% exhibited a high level of preventive behavior in terms of dengue vector control measures. Preventive behaviors were significantly associated with information provided from sources that included health personnel (p = 0.038) and heads of villages (p=0.031) and with knowledge levels (p < 0.001). This study suggests that proactive health education through appropriated mass media and community clean-up campaigns should strengthen and encourage community participation, particularly in terms of addressing mosquito larvae in overlooked places, such as the participants' own homes, for example, in flower vases and ant traps.

  11. Integrating normal and pathological personality: relating the DSM-5 trait-dimensional model to general traits of personality.

    Science.gov (United States)

    Watson, David; Stasik, Sara M; Ro, Eunyoe; Clark, Lee Anna

    2013-06-01

    The Personality Inventory for DSM-5 (PID-5) assesses traits relevant for diagnosing personality disorder in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5). We examined the PID-5 in relation to the Big-Three and Big-Five personality traits in outpatient and community adult samples. Domain-level analyses revealed that PID-5 Negative Affectivity correlated strongly with Neuroticism, and PID-5 Antagonism and Disinhibition correlated strongly negatively with Agreeableness and Conscientiousness, respectively; Antagonism and Disinhibition also were both linked strongly to Big-Three trait Disinhibition. PID-5 Detachment related strongly to personality, including Extraversion/Positive Temperament, but did not show its expected specificity to this factor. Finally, PID-5 Psychoticism correlated only modestly with Openness. Facet-level analyses indicated that some PID-5 scales demonstrated replicable deviations from their DSM-5 model placements. We discuss implications of these data for the DSM-5 model of personality disorder, and for integrating it with well-established structures of normal personality.

  12. Impulsivity toward food reward is related to BMI: Evidence from intertemporal choice in obese and normal-weight individuals.

    Science.gov (United States)

    Schiff, Sami; Amodio, Piero; Testa, Giulia; Nardi, Mariateresa; Montagnese, Sara; Caregaro, Lorenza; di Pellegrino, Giuseppe; Sellitto, Manuela

    2016-12-01

    Obesity is a medical condition frequently associated with psychopathological symptoms and neurocognitive and/or personality traits related to impulsivity. Impulsivity during intertemporal choices seems to be typical of obese individuals. However, so far, the specific relationship between different types of reward and neuropsychological and psychopathological profile are yet to be unravelled. Here, we investigated impulsive choice for primary and secondary reward in obese individuals and normal-weight controls with comparable neuropsychological and psychopathological status. Participants performed three intertemporal choice tasks involving food, money, and discount voucher, respectively. Moreover, they completed a battery of neuropsychological tests and psychometric questionnaires assessing psychopathological state, impulsivity, and personality traits. Obese individuals showed increased preference for immediate food reward compared with controls, whereas no group difference emerged concerning money and discount voucher. Moreover, the higher the body mass index (BMI), the steeper the food discounting. These findings emerged in light of comparable neuropsychological and psychopathological profile between groups. Steeper food discounting in obese individuals appears to be related to BMI but not to psychopathological and neuropsychological profile. We suggest using intertemporal choice in the clinical practice as measure of the effectiveness of different types of intervention (e.g., educational, psychological, pharmacological or surgical) aimed at reducing impulsivity toward food and increasing cognitive control during food intake in obese individuals. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. Effects of Normalized Difference Vegetation Index and Related Wavebands' Characteristics on Detecting Spatial Heterogeneity Using Variogram-based Analysis

    Institute of Scientific and Technical Information of China (English)

    WEN Zhaofei; ZHANG Ce; ZHANG Shuqing; DING Changhong; LIU Chunyue; PAN Xin; LI Huapeng; SUN Yan

    2012-01-01

    Spatial heterogeneity is widely used in diverse applications,such as recognizing ecological process,guiding ecological restoration,managing land use,etc.Many researches have focused on the inherent scale multiplicity of spatial heterogeneity by using various environmental variables.How these variables affect their corresponding spatial heterogeneities,however,have received little attention.In this paper,we examined the effects of characteristics of normalized difference vegetation index (NDVI) and its related bands variable images,namely red and near infrared (NIR),on their corresponding spatial heterogeneity detection based on variogram models.In a coastal wetland region,two groups of study sites with distinct fractal vegetation cover were tested and analyzed.The results show that:1) in high fractal vegetation cover (H-FVC) area,NDVI and NIR variables display a similar ability in detecting the spatial heterogeneity caused by vegetation growing status structure; 2) in low fractal vegetation cover (L-FVC) area,the NIR and red variables outperform NDVI in the survey of soil spatial heterogeneity; and 3) generally,NIR variable is ubiquitously applicable for vegetation spatial heterogeneity investigation in different fractal vegetation covers.Moreover,as variable selection for remote sensing applications should fully take the characteristics of variables and the study object into account,the proposed variogram analysis method can make the variable selection objectively and scientifically,especially in studies related to spatial heterogeneity using remotely sensed data.

  14. Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk.

    Science.gov (United States)

    Kennedy, Kristen M; Raz, Naftali

    2009-11-10

    Even successful aging is associated with regional brain shrinkage and deterioration of the cerebral white matter. Aging also brings about an increase in vascular risk, and vascular impairment may be a potential mechanism behind the observed patterns of aging. The goals of this study were to characterize the normal age differences in white matter integrity in several brain regions across the adult life span and to assess the modifying effect of vascular risk on the observed pattern of regional white matter integrity. We estimated fractional anisotropy and diffusivity of white matter in nine cerebral regions of interest in 77 healthy adults (19-84 years old). There was a widespread reduction of white matter anisotropy with age, and prefrontal and occipital regions evidenced the greatest age-related differences. Diffusivity increased with age, and the magnitude of age differences increased beginning with the middle of the fifth decade. Vascular risk factors modified age differences in white matter integrity. Clinically diagnosed and treated arterial hypertension was associated with reduced white matter anisotropy and increased diffusivity beyond the effects of age. In the normotensive participants, elevation of arterial pulse pressure (a surrogate of arterial stiffness) was linked to deterioration of the white matter integrity in the frontal regions. Although the causal role of vascular risk in brain aging is unclear, the observed pattern of effects suggests that vascular risk may drive the expansion of age-related white matter damage from anterior to posterior regions.

  15. Circulating thrombopoietin levels in normal healthy blood donors and in aplastic anemia patients in relation to disease severity

    Directory of Open Access Journals (Sweden)

    Abhay Singh

    2015-01-01

    Full Text Available Background: Thrombopoietin (TPO is the key hematopoietic growth factor regulating the production of platelets from bone marrow megakaryocytes and maintaining platelet hemostasis. This study was done to find any relationship between the levels of thrombopoietin and the severity of disease in patients with aplastic anemia. Materials and Methods: Serum samples were collected from 52 patients with a confirmed diagnosis of aplastic anemia and 45 normal healthy blood donors of both sexes over a period of 2 years, and TPO was estimated by using commercially available TPO-specific-enzyme-linked immunosorbent assay. Results: The median TPO level of 1190 pg/ml (range 625-7651 pg/ml in aplastic anemia patients was significantly higher than the median TPO level of 121.1 pg/ml (81.25-237.7 pg/ml in normal healthy blood donors (P = 0.000. No significant difference was observed in TPO levels of male and female patients (P = 0.453. The median TPO concentrations observed in very severe aplastic anemia, severe aplastic anemia, and nonsevere aplastic anemia were 2765 pg/ml (range 625-6451 pg/ml, 1190 pg/ml (range 672.1-7651 pg/ml, and 1111.5 pg/ml (range 761.1-2289.2 pg/ml, respectively. TPO in patients of very severe aplastic anemia was significantly higher than patients of nonsevere aplastic anemia (P = 0.043, with no significant relation among rest of the groups. Discussion: TPO levels in aplastic anemia patients were significantly higher than in healthy blood donors; however, in aplastic anemia patients TPO levels were significantly higher only in patients with very severe disease.

  16. GPU Accelerated Vector Median Filter

    Science.gov (United States)

    Aras, Rifat; Shen, Yuzhong

    2011-01-01

    Noise reduction is an important step for most image processing tasks. For three channel color images, a widely used technique is vector median filter in which color values of pixels are treated as 3-component vectors. Vector median filters are computationally expensive; for a window size of n x n, each of the n(sup 2) vectors has to be compared with other n(sup 2) - 1 vectors in distances. General purpose computation on graphics processing units (GPUs) is the paradigm of utilizing high-performance many-core GPU architectures for computation tasks that are normally handled by CPUs. In this work. NVIDIA's Compute Unified Device Architecture (CUDA) paradigm is used to accelerate vector median filtering. which has to the best of our knowledge never been done before. The performance of GPU accelerated vector median filter is compared to that of the CPU and MPI-based versions for different image and window sizes, Initial findings of the study showed 100x improvement of performance of vector median filter implementation on GPUs over CPU implementations and further speed-up is expected after more extensive optimizations of the GPU algorithm .

  17. VLSI Processor For Vector Quantization

    Science.gov (United States)

    Tawel, Raoul

    1995-01-01

    Pixel intensities in each kernel compared simultaneously with all code vectors. Prototype high-performance, low-power, very-large-scale integrated (VLSI) circuit designed to perform compression of image data by vector-quantization method. Contains relatively simple analog computational cells operating on direct or buffered outputs of photodetectors grouped into blocks in imaging array, yielding vector-quantization code word for each such block in sequence. Scheme exploits parallel-processing nature of vector-quantization architecture, with consequent increase in speed.

  18. Vectors Point Toward Pisa

    Science.gov (United States)

    Dean, Richard A.

    1971-01-01

    The author shows that the set of all sequences in which each term is the sum of the two previous terms forms a vector space of dimension two. He uses this result to obtain the formula for the Fibonacci sequence and applies the same technique to other linear recursive relations. (MM)

  19. Analysis in Vector Spaces

    CERN Document Server

    Akcoglu, Mustafa A; Ha, Dzung Minh

    2011-01-01

    A rigorous introduction to calculus in vector spaces The concepts and theorems of advanced calculus combined with related computational methods are essential to understanding nearly all areas of quantitative science. Analysis in Vector Spaces presents the central results of this classic subject through rigorous arguments, discussions, and examples. The book aims to cultivate not only knowledge of the major theoretical results, but also the geometric intuition needed for both mathematical problem-solving and modeling in the formal sciences. The authors begin with an outline of key concepts, ter

  20. Studies on bacterial chromatophores II. Energy transfer and photooxidative bleaching of bacteriochlorophyll in relation to structure in normal and carotenoid-depleted Chromatium

    NARCIS (Netherlands)

    Bril, C.

    1963-01-01

    Electronic energy transfer, fluorescence emission spectra and photooxidative bleaching of bacteriochlorophyll in Chromatium chromatophores were shown to be affected by detergent action and by inhibition of normal carotenoid synthesis in the parent cells. These phenomena are discussed in relation to

  1. Relation between regional distribution of /sup 201/Tl and myocardial blood flow in normal, acutely ischemic, and infarcted myocardium

    Energy Technology Data Exchange (ETDEWEB)

    Chu, A.; Murdock, R.H. Jr.; Cobb, F.R.

    1982-11-01

    Myocardial localization of /sup 201/Tl was compared with direct measurements of myocardial perfusion in normal, acutely ischemic, and recently infarcted myocardium. Studies were performed in 6 chronically instrumented dogs that were subjected to myocardial infarction by occlusion of the proximal left circumflex coronary artery. Four days after myocardial infarction, /sup 201/Tl and 9 +/- 1 micrometer /sup 95/Nb-labelled microspheres were injected simultaneously after acute left anterior descending coronary arterial occlusion; the animals were killed 5 minutes later and the entire left ventricle was sectioned into 1 to 2 g samples. Regression analyses between /sup 201/Tl activity and regional myocardial blood flow using all myocardial samples demonstrated a very close linear relation in each dog; r values were 0.98 or greater, indicating that the initial localization of /sup 201/Tl in acutely ischemic and recently infarcted myocardium as a function of regional blood flow was essentially identical. Consequently, in each dog the regional distribution of /sup 201/Tl closely approximated myocardial perfusion over a wide range of blood flow and potentially different local metabolic conditions that may be encountered in the clinical use of the isotope.

  2. Stromal laminin chain distribution in normal, hyperplastic and malignant oral mucosa: relation to myofibroblast occurrence and vessel formation.

    Science.gov (United States)

    Franz, Marcus; Wolheim, Anke; Richter, Petra; Umbreit, Claudia; Dahse, Regine; Driemel, Oliver; Hyckel, Peter; Virtanen, Ismo; Kosmehl, Hartwig; Berndt, Alexander

    2010-04-01

    The contribution of stromal laminin chain expression to malignant potential, tumour stroma reorganization and vessel formation in oral squamous cell carcinoma (OSCC) is not fully understood. Therefore, the expression of the laminin chains alpha2, alpha3, alpha4, alpha5 and gamma2 in the stromal compartment/vascular structures in OSCC was analysed. Frozen tissue of OSCC (9x G1, 24x G2, 8x G3) and normal (2x)/hyperplastic (11x) oral mucosa was subjected to laminin chain and alpha-smooth muscle actin (ASMA) immunohistochemistry. Results were correlated to tumour grade. The relation of laminin chain positive vessels to total vessel number was assessed by immunofluorescence double labelling with CD31. Stromal laminin alpha2 chain significantly decreases and alpha3, alpha4, alpha5 and gamma2 chains and also ASMA significantly increase with rising grade. The amount of stromal alpha3, alpha4 and gamma2 chains significantly increased with rising ASMA positivity. There is a significant decrease in alpha3 chain positive vessels with neoplastic transformation. Mediated by myofibroblasts, OSCC development is associated with a stromal up-regulation of laminin isoforms possibly contributing to a migration promoting microenvironment. A vascular basement membrane reorganization concerning alpha3 and gamma2 chain laminins during tumour angioneogenesis is suggested.

  3. Quantitative analysis of the closure pattern of the neurocentral junction as related to preexistent rotation in the normal immature spine.

    Science.gov (United States)

    Schlösser, Tom P C; Vincken, Koen L; Attrach, Hamid; Kuijf, Hugo J; Viergever, Max A; Janssen, Michiel M A; Castelein, René M

    2013-07-01

    The normal spine is not a symmetrical structure. In recent studies, we demonstrated the presence of an axial rotational pattern that is similar to what is seen in the most prevalent curve patterns in idiopathic scoliosis at different ages. This suggests that if the spine starts to decompensate into scoliosis, it follows this preexistent rotational pattern. In scoliosis, the neurocentral junctions (NCJs) close asymmetrically, which leads to a different pedicle morphology in the convexity and concavity of the curve. The present study aimed to establish at which age the NCJ closes in different regions of the spine, whether it closes asymmetrically in the nonscoliotic spine as well and whether the closure pattern is related to the earlier demonstrated preexistent rotation. To evaluate the closure pattern and surface area of the left and right NCJs throughout the normal immature spine in relation to the preexistent spinal rotation at different ages. Retrospective cohort study using a systematic, semiautomatic analysis. Computed tomography (CT) scans of the thorax and abdomen of 199 nonscoliotic children (0-16 years old) were systemically analyzed. CT scans had been obtained for several reasons unrelated to this study, for example, recurrent respiratory infections, malignant disease (not involving the spine), or work up before bone marrow transplantation. Scans were categorized according to the criteria of the Scoliosis Research Society into infantile (0-3 years old), juvenile (4-9 years old), and adolescent (10-16 years old) age cohorts. Closure, absolute surface area, and the angle between the longitudinal axis of the left and right NCJ and preexistent vertebral rotation at each spinal level. Transverse CT slices were systemically analyzed for closure and asymmetry of the absolute area of 4,992 NCJs from spinal levels T2-L5. The outcome measures were analyzed semiautomatically using custom-made software developed at our institution (ImageXplorer; Image Sciences

  4. Spinless relativistic particle in energy-dependent potential and normalization of the wave function

    Science.gov (United States)

    Benchikha, Amar; Chetouani, Lyazid

    2014-06-01

    The problem of normalization related to a Klein-Gordon particle subjected to vector plus scalar energy-dependent potentials is clarified in the context of the path integral approach. In addition the correction relating to the normalizing constant of wave functions is exactly determined. As examples, the energy dependent linear and Coulomb potentials are considered. The wave functions obtained via spectral decomposition, were found exactly normalized.

  5. Brane World black holes in Teleparallel Theory Equivalent to General Relativity and their Killing vectors, Energy, Momentum and Angular-Momentum

    CERN Document Server

    Nashed, Gamal G L

    2009-01-01

    The energy-momentum tensor, which is coordinate independent, is used to calculate energy, momentum and angular-momentum of two different tetrad fields. Although, the two tetrad fields reproduce the same space-time their energies are different. Therefore, a regularized expression of the gravitational energy-momentum tensor of the teleparallel equivalent of general relativity, (TEGR), is used to make the energies of the two tetrad fields equal. The definition of the gravitational energy-momentum is used to investigate the energy within the external event horizon. The components of angular-momentum associated with these space-times are calculated. In spite that we use a static space-times, we get a non-zero component of angular-momentum! Therefore, we derive the killing vectors associated with these space-times using the definition of the Lie derivative of a second rank tensor in the framework of the TEGR to make the picture more clear.

  6. Diffuse white matter tract abnormalities in clinically normal ageing retired athletes with a history of sports-related concussions.

    Science.gov (United States)

    Tremblay, Sebastien; Henry, Luke C; Bedetti, Christophe; Larson-Dupuis, Camille; Gagnon, Jean-François; Evans, Alan C; Théoret, Hugo; Lassonde, Maryse; De Beaumont, Louis

    2014-11-01

    Sports-related concussions have been shown to lead to persistent subclinical anomalies of the motor and cognitive systems in young asymptomatic athletes. In advancing age, these latent alterations correlate with detectable motor and cognitive function decline. Until now, the interacting effects of concussions and the normal ageing process on white matter tract integrity remain unknown. Here we used a tract-based spatial statistical method to uncover potential white matter tissue damage in 15 retired athletes with a history of concussions, free of comorbid medical conditions. We also investigated potential associations between white matter integrity and declines in cognitive and motor functions. Compared to an age- and education-matched control group of 15 retired athletes without concussions, former athletes with concussions exhibited widespread white matter anomalies along many major association, interhemispheric, and projection tracts. Group contrasts revealed decreases in fractional anisotropy, as well as increases in mean and radial diffusivity measures in the concussed group. These differences were primarily apparent in fronto-parietal networks as well as in the frontal aspect of the corpus callosum. The white matter anomalies uncovered in concussed athletes were significantly associated with a decline in episodic memory and lateral ventricle expansion. Finally, the expected association between frontal white matter integrity and motor learning found in former non-concussed athletes was absent in concussed participants. Together, these results show that advancing age in retired athletes presenting with a history of sports-related concussions is linked to diffuse white matter abnormalities that are consistent with the effects of traumatic axonal injury and exacerbated demyelination. These changes in white matter integrity might explain the cognitive and motor function declines documented in this population. © The Author (2014). Published by Oxford University

  7. Evaluation of the relation between triceps surae H-reflex, M-response latencies and thigh length in normal population

    Directory of Open Access Journals (Sweden)

    Saeid Khosrawi

    2013-01-01

    Full Text Available Background: The H-reflex is a useful electrophysiological procedure for evaluating the status of the peripheral nervous system, especially at the proximal segment of the peripheral nerve. The purpose of this study is to investigate the relation between triceps surae H-reflex and M- response latencies and thigh length in normal population, in order to determine if there is any regression equation between them. Materials and Methods: After screening 75 volunteers by considering inclusion and exclusion criteria, 72 of them were selected to enroll into our study (34 men and 38 women with the mean age of 36.04 ± 7.7 years. In all of the subjects H-reflex and M-response latencies were recorded by standard electrophysiological techniques and thigh length was measured. Finally, our data was analyzed for its relations with respect to ages in both sexes by appropriate statistical and mathematical methods. Results: Mean ± SD for H-reflex latency was 27.94 ± 1.6 ms. We found a significant correlation between H-reflex latency and M-latency (r = 0.28, no significant correlation was found between H-reflex latency and thigh length (r = -0.051. Finally based on our findings we introduce a new formula in this paper.Conclusion: We found a significant correlation among of M-response latency and other variables (H-reflex latency and thigh length. Despite this it was eliminated from our formula. The relationship between H-reflex latency and age was significant. Further studies are required to delineate the clinical usage and interpretation of the formula, which we found in this study.

  8. Pre-β-HDL formation relates to high-normal free thyroxine in type 2 diabetes mellitus.

    Science.gov (United States)

    van Tienhoven-Wind, Lynnda J N; Perton, Frank G; Dullaart, Robin P F

    2016-01-01

    Low-normal thyroid function within the euthyroid range may influence plasma lipoprotein levels. Associations between variation in thyroid function and pre-β-high density lipoproteins (pre-β-HDL), i.e. lipid-poor or lipid free HDL particles that act as initial acceptor of cell-derived cholesterol, are unknown. We determined relationships of plasma pre-β-HDL with thyroid function in euthyroid subjects with and without type 2 diabetes mellitus (T2DM). TSH, free T4, plasma (apo)lipoproteins, pre-β-HDL, pre-β-HDL formation (pre-β-HDL generation during incubation with lecithin:cholesterol acyltransferase being inhibited) and phospholipid transfer protein (PLTP) activity were measured in fasting plasma from 72 T2DM and 82 non-diabetic subjects. TSH was similar and free T4 was slightly higher (P diabetic subjects. HDL cholesterol and apoA-I were lower, whereas pre-β-HDL (expressed as % of apoA-I), triglycerides and PLTP activity were higher in T2DM (P HDL formation (in apoA-I concentration and in % of apoA-I) was positively related to free T4, PLTP activity, total cholesterol and triglycerides (P HDL formation was positively related to free T4 (in apoA-I concentration: β = 0.278, P = 0.014; in % of apoA-I: β = 0.343, P = 0.003) in T2DM, but not in non-diabetic subjects (both P > 0.30; interaction terms: both P HDL in T2DM.

  9. Bunyavirus-vector interactions.

    Science.gov (United States)

    Beaty, B J; Bishop, D H

    1988-06-01

    Recent advances in the genetics and molecular biology of bunyaviruses have been applied to understanding bunyavirus-vector interactions. Such approaches have revealed which virus gene and gene products are important in establishing infections in vectors and in transmission of viruses. However, much more information is required to understand the molecular mechanisms of persistent infections of vectors which are lifelong but apparently exert no untoward effect. In fact, it seems remarkable that LAC viral antigen can be detected in almost every cell in an ovarian follicle, yet no untoward effect on fecundity and no teratology is seen. Similarly the lifelong infection of the vector would seem to provide ample opportunity for bunyavirus evolution by genetic drift and, under the appropriate circumstances, by segment reassortment. The potential for bunyavirus evolution by segment reassortment in vectors certainly exists. For example the Group C viruses in a small forest in Brazil seem to constitute a gene pool, with the 6 viruses related alternately by HI/NT and CF reactions, which assay respectively M RNA and S RNA gene products (Casals and Whitman, 1960; Shope and Causey, 1962). Direct evidence for naturally occurring reassortant bunyaviruses has also been obtained. Oligonucleotide fingerprint analyses of field isolates of LAC virus and members of the Patois serogroup of bunyaviruses have demonstrated that reassortment does occur in nature (El Said et al., 1979; Klimas et al., 1981; Ushijima et al., 1981). Determination of the genotypic frequencies of viruses selected by the biological interactions of viruses and vectors after dual infection and segment reassortment is an important issue. Should a virus result that efficiently interacts with alternate vector species, the virus could be expressed in different circumstances with serious epidemiologic consequences. Dual infection of vectors with different viruses is not unlikely, because many bunyaviruses are sympatric in

  10. Are local plague endemicity and ecological characteristics of vectors and reservoirs related? A case study in north-east Tanzania

    Directory of Open Access Journals (Sweden)

    Herwig LEIRS

    2009-06-01

    Full Text Available The pattern of plague endemicity in Tanzania is characterized by continuous re-appearance of the disease in some locations, while in other neighbouring villages the disease has never or seldom been observed. To understand the reasons for this pattern, we studied small mammals and fleas species composition, diversity and relative abundances in two plague-endemic and two plague-free locations. We asked (a whether fleas more abundant in plague-endemic locations differ in their characteristic abundance and the degree of their host specificity from fleas most abundant in plague-free locations and (b whether hosts more abundant in plague-endemic locations differ in the diversity of their flea assemblages from hosts most abundant in plague-free locations. We characterized (a host species by species richness and degree of taxonomic relatedness of its flea assemblages and (b each flea species by its mean abundance and size, and degree of taxonomic relatedness of its host spectrum and compared their relative abundances between locations. No significant difference between plague-endemic and plague-free locations in either host density or any variable related to flea abundance or diversity was found. However, there was marginally significant effect of taxonomic distinctness of a flea assemblage harboured by a host on its probability to be more abundant in either plague-endemic or plague-free locations. Furthermore, hosts more abundant in plague-endemic locations tended to harbour closely-related fleas. Finally, while opportunistic and specialist fleas were equally distributed in both sets of locations, fleas exploiting distantly-related hosts were found mainly in plague-free locations during the rainy season. We suggest that the observed patterns might arise due to seasonal and spatial differences in local microclimatic conditions and landscape connectivity[Current Zoology 55(3:199–211, 2009].

  11. Are local plague endemicity and ecological characteristics of vectors and reservoirs related? A case study in north-east Tanzania

    Institute of Scientific and Technical Information of China (English)

    Anne LAUDISOIT; Simon NEERINCKX; Rhodes H.MAKUNDI; Herwig LEIRS; Boris R.KRASNOV

    2009-01-01

    The pattern of plague endemicity in Tanzania is characterized by continuous re-appearance of the disease in some locations, while in other neighbouring villages the disease has never or seldom been observed. To understand the reasons for this pattern, we studied small mammal and flea species composition, diversity and relative abundances in two plague-endemic and two plague-free locations. We asked (a) whether fleas more abundant in plague-endemic locations differ in their characteristic abundance and the degree of their host specificity from fleas more abundant in plague-free locations and (b) whether hosts most abundant in plagne-endemic locations differ in the diversity of their flea assemblages from hosts most abundant in plague-free locations. We characterized (a) each host species by species richness and degree of taxonomic relatedness of its flea assemblages and (b) each flea species by its mean abundance and size, and degree of taxonomic relatedness of its host spectrum and compared their relative abundances between locations. No significant difference between plague-endemic and plague-free locations in either host density or any variable related to flea abundance or diversity was found. However, there was marginally significant effect of taxonomic distinctness of a flea assemblage harboured by a host on its probability to be more abundant in either plague-endemic or plague-free locations. Furthermore, hosts more abundant in plague-endemic locations tended to harbeur closely-related fleas. Finally, while opportunistic and specialist fleas were equally distributed in both sets of locations, fleas exploiting distantly-related hosts were found mainly in plague-free locations during the rainy season. We suggest that the observed patterns might arise due to seasonal and spatial differences in local microclimatic conditions and landscape connectivity.

  12. Directional Transverse Oscillation Vector Flow Estimation

    DEFF Research Database (Denmark)

    Jensen, Jørgen Arendt

    2017-01-01

    A method for estimating vector velocities using transverse oscillation (TO) combined with directional beamforming is presented. In Directional Transverse Oscillation (DTO) a normal focused field is emitted and the received signals are beamformed in the lateral direction transverse to the ultrasou...... increase in SD to 15.7%, but a maintained bias of -3.5% from 126 to 156 mm. Data for a pulsating flow has also been acquired for 15 cardiac cycles using a CompuFlow 1000 pump. The relative SD was here 7.4% for a femoral artery waveform....

  13. Comparison of normalization methods for differential gene expression analysis in RNA-Seq experiments: A matter of relative size of studied transcriptomes.

    Science.gov (United States)

    Maza, Elie; Frasse, Pierre; Senin, Pavel; Bouzayen, Mondher; Zouine, Mohamed

    2013-11-01

    In recent years, RNA-Seq technologies became a powerful tool for transcriptome studies. However, computational methods dedicated to the analysis of high-throughput sequencing data are yet to be standardized. In particular, it is known that the choice of a normalization procedure leads to a great variability in results of differential gene expression analysis. The present study compares the most widespread normalization procedures and proposes a novel one aiming at removing an inherent bias of studied transcriptomes related to their relative size. Comparisons of the normalization procedures are performed on real and simulated data sets. Real RNA-Seq data sets analyses, performed with all the different normalization methods, show that only 50% of significantly differentially expressed genes are common. This result highlights the influence of the normalization step on the differential expression analysis. Real and simulated data sets analyses give similar results showing 3 different groups of procedures having the same behavior. The group including the novel method named "Median Ratio Normalization" (MRN) gives the lower number of false discoveries. Within this group the MRN method is less sensitive to the modification of parameters related to the relative size of transcriptomes such as the number of down- and upregulated genes and the gene expression levels. The newly proposed MRN method efficiently deals with intrinsic bias resulting from relative size of studied transcriptomes. Validation with real and simulated data sets confirmed that MRN is more consistent and robust than existing methods.

  14. Glycinergic synaptic transmission in the cochlear nucleus of mice with normal hearing and age-related hearing loss.

    Science.gov (United States)

    Xie, Ruili; Manis, Paul B

    2013-10-01

    The principal inhibitory neurotransmitter in the mammalian cochlear nucleus (CN) is glycine. During age-related hearing loss (AHL), glycinergic inhibition becomes weaker in CN. However, it is unclear what aspects of glycinergic transmission are responsible for weaker inhibition with AHL. We examined glycinergic transmission onto bushy cells of the anteroventral CN in normal-hearing CBA/CaJ mice and in DBA/2J mice, a strain that exhibits an early onset AHL. Glycinergic synaptic transmission was examined in brain slices of mice at 10-15 postnatal days old, 20-35 days old, and at 6-7 mo old. Spontaneous inhibitory postsynaptic current (sIPSC) event frequency and amplitude were the same among all three ages in both strains of mice. However, the amplitudes of IPSCs evoked (eIPSC) from stimulating the dorsal CN were smaller, and the failure rate was higher, with increasing age due to decreased quantal content in both mouse strains, independent of hearing status. The coefficient of variation of the eIPSC amplitude also increased with age. The decay time constant (τ) of sIPSCs and eIPSCs were constant in CBA/CaJ mice at all ages, but were significantly slower in DBA/2J mice at postnatal days 20-35, following the onset of AHL, and not at earlier or later ages. Our results suggest that glycinergic inhibition at the synapses onto bushy cells becomes weaker and less reliable with age through changes in release. However, the hearing loss in DBA/2J mice is accompanied by a transiently enhanced inhibition, which could disrupt the balance of excitation and inhibition.

  15. Cytodifferentiation of the postnatal mouse stomach in normal and Huntingtin-interacting protein 1-related-deficient mice

    Science.gov (United States)

    Keeley, Theresa M.

    2010-01-01

    Huntingtin-interacting protein 1-related (Hip1r) is highly expressed in gastric parietal cells, where it participates in vesicular trafficking associated with acid secretion. Hip1r-deficient mice have a progressive remodeling of the mucosa, including apoptotic loss of parietal cells, glandular hypertrophy, mucous cell metaplasia, and reduced numbers of zymogenic cells. In this study, we characterized gastric gland development in wild-type and Hip1r-deficient mice to define normal development, as well as the timing and sequence of the cellular transformation events in the mutant stomach. Postnatal (newborn to 8-wk-old) stomachs were examined by histological and gene expression analysis. At birth, gastric glands in wild-type and mutant mice were rudimentary and mature gastric epithelial cells were not apparent, although marker expression was detected for most cell lineages. Interestingly, newborns exhibited unusual cell types, including a novel surface cell filled with lipid and cells that coexpressed markers of mature mucous neck and zymogenic cells. Glandular morphogenesis proceeded rapidly in both genotypes, with gastric glands formed by weaning at 3 wk of age. In the Hip1r-deficient stomach, epithelial cell remodeling developed in a progressive manner. Initially, in the perinatal stomach, cellular changes were limited to parietal cell apoptosis. Other epithelial cell changes, including apoptotic loss of zymogenic cells and expansion of metaplastic mucous cells, emerged several weeks later when the glands were morphologically mature. Thus, parietal cell loss appeared to be the initiating event in Hip1r-deficient mice, with secondary remodeling of the other gastric epithelial cells. PMID:20813912

  16. Relation between postpartum depression and childbirth practices recommended by Estrategia de atención al parto normal

    Directory of Open Access Journals (Sweden)

    Ana Belén Laviña Castán

    2013-03-01

    Full Text Available The high prevalence of postpartum depression (PPD (rates between 10-20% in developed countries and its serious consequences for both women and children, highlight the need to continue studying the factors affecting DPP.Many studies have looked for factors related to this disorder, but none has carried out a comprehensive analysis to find out its relationship with childbirth practices, despite the possible relationship between the childbirth experiences and the emotional disorders in mothers, and the early alteration of the link between mother and child, that we have seen during our professional lifes.The objective of this research is to determine the prevalence of PPD among women whose childbirth took place at Miguel Servet Hospital, in Zaragoza, during October and November 2011, and to analyse its connection to carrying out clinical practice based on the best know-how available recommended by “Estrategia del parto normal del Ministerio de Sanidad y Consumo (2007”. An observational and transverse study based was carried out that consisted of an initial survey to an approximate sample of 600 women with a later phone call between the sixth and eighth week after the childbirth to detect women suffering from PPD, using the Edinburgh Postnatal Depression Scale (EPDS. The relationship between each variable defined within “Estrategia de atención del parto normal” and the existance of PPD will be studied; the following variables will be taken into account too, due to its high importance: parity, gestational pathology, prematurity, nationality and fulfilment of her childbirth.

  17. The normal limits, subclinical significance, related metabolic derangements and distinct biological effects of body site-specific adiposity in relatively healthy population.

    Directory of Open Access Journals (Sweden)

    Chun-Ho Yun

    Full Text Available BACKGROUND: The accumulation of visceral adipose tissue that occurs with normal aging is associated with increased cardiovascular risks. However, the clinical significance, biological effects, and related cardiometabolic derangements of body-site specific adiposity in a relatively healthy population have not been well characterized. MATERIALS AND METHODS: In this cross-sectional study, we consecutively enrolled 608 asymptomatic subjects (mean age: 47.3 years, 27% female from 2050 subjects undergoing an annual health survey in Taiwan. We measured pericardial (PCF and thoracic peri-aortic (TAT adipose tissue volumes by 16-slice multi-detector computed tomography (MDCT (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, USA and related these to clinical characteristics, body fat composition (Tanita 305 Corporation, Tokyo, Japan, coronary calcium score (CCS, serum insulin, high-sensitivity C-reactive protein (Hs-CRP level and circulating leukocytes count. Metabolic risk was scored by Adult Treatment Panel III guidelines. RESULTS: TAT, PCF, and total body fat composition all increased with aging and higher metabolic scores (all p<0.05. Only TAT, however, was associated with higher circulating leukocyte counts (ß-coef.:0.24, p<0.05, serum insulin (ß-coef.:0.17, p<0.05 and high sensitivity C-reactive protein (ß-coef.:0.24, p<0.05. These relationships persisted after adjustment in multivariable models (all p<0.05. A TAT volume of 8.29 ml yielded the largest area under the receiver operating characteristic curve (AUROC: 0.79, 95%CI: 0.74-0.83 to identify metabolic syndrome. TAT but not PCF correlated with higher coronary calcium score after adjustment for clinical variables (all p<0.05. CONCLUSION: In our study, we observe that age-related body-site specific accumulation of adipose tissue may have distinct biological effects. Compared to other adiposity measures, peri-aortic adiposity is more tightly associated with cardiometabolic risk profiles and

  18. Vector nematicons

    CERN Document Server

    Horikis, Theodoros P

    2016-01-01

    Families of soliton pairs, namely vector solitons, are found within the context of a coupled nonlocal nonlinear Schrodinger system of equations, as appropriate for modeling beam propagation in nematic liquid crystals. In the focusing case, bright soliton pairs have been found to exist provided their amplitudes satisfy a specific condition. In our analytical approach, focused on the defocusing regime, we rely on a multiscale expansion methods, which reveals the existence of dark-dark and antidark-antidark solitons, obeying an effective Korteweg-de Vries equation, as well as dark-bright solitons, obeying an effective Mel'nikov system. These pairs are discriminated by the sign of a constant that links all physical parameters of the system to the amplitude of the stable continuous wave solutions, and, much like the focusing case, the solitons' amplitudes are linked leading to mutual guiding.

  19. A Comparison of the Age-MLU Relation in Normal and Specifically Language-Impaired Preschool Children.

    Science.gov (United States)

    Klee, Thomas; And Others

    1989-01-01

    The study found that mean length of utterance (MLU) and age were significantly correlated in both language impaired (N=24) and normal preschool children with rates of MLU change also similar for both groups of children. (DB)

  20. Tables of Relative Strengths of Spectral Lines with Mixed Vector Couplings: Dipole Transitions Between LS and Other Couplings

    Science.gov (United States)

    Gongora, T. A.; Escalante, V.

    1991-04-01

    RESUMEN Se presentan tablas de intensidades de oscilador de dipolares del tipo (2SP+1)Lp ni - (2SP+l)Lp ml' para 0 esquema de acoplamiento LS y el otro se describe en el esquema de acoplamiento LK, jK 6 jj. Nuestros resultados son utiles en Ia interpretaci6n e identificaci6n de lfneas espectrales entre estados con ntimeros cuanticos similares. ABSTRACT Tables are presented for the relative strength of dipole transitions of the type (2SP+l)Lp ni - (2SP+l)Lp ml' for 0 < Sp < 2, 0 < Lp < 2, 1 < 1 <4, and for any n and m, in which one of the states is described with the Ls coupling scheme, and the other is described with the LK, jK, or jj coupling scheme. Our results are useful in the interpretation and identification of spectral lines between states with similar quantum numbers. K words: ATOMIC AND MOLECULAR DATA - PROBABILITES

  1. Safety considerations in vector development.

    Science.gov (United States)

    Kappes, J C; Wu, X

    2001-11-01

    The inadvertent production of replication competent retrovirus (RCR) constitutes the principal safety concern for the use of lentiviral vectors in human clinical protocols. Because of limitations in animal models to evaluate lentiviral vectors for their potential to recombine and induce disease, the vector design itself should ensure against the emergence of RCR in vivo. Issues related to RCR generation and one approach to dealing with this problem are discussed in this chapter. To assess the risk of generating RCR, a highly sensitive biological assay was developed to specifically detect vector recombination in transduced cells. Analysis of lentiviral vector stocks has shown that recombination occurs during reverse transcription in primary target cells. Rejoining of viral protein-coding sequences of the packaging construct and cis-acting sequences of the vector was demonstrated to generate env-minus recombinants (LTR-gag-pol-LTR). Mobilization of recombinant lentiviral genomes was also demonstrated but was dependent on pseudotyping of the vector core with an exogenous envelope protein. 5' sequence analysis has demonstrated that recombinants consist of U3, R, U5, and the psi packaging signal joined with an open gag coding region. Analysis of the 3' end has mapped the point of vector recombination to the poly(A) tract of the packaging construct's mRNA. The state-of-the-art third generation packaging construct and SIN vector also have been shown to generate env-minus proviral recombinants capable of mobilizing retroviral DNA when pseudotyped with an exogenous envelope protein. A new class of HIV-based vector (trans-vector) was recently developed that splits the gag-pol component of the packaging construct into two parts: one that expresses Gag/Gag-Pro and another that expresses Pol (RT and IN) fused with Vpr. Unlike other lentiviral vectors, the trans-vector has not been shown to form recombinants capable of DNA mobilization. These results indicate the trans-vector

  2. Search for Anisotropic Light Propagation as a Function of Laser Beam Alignment Relative to the Earth's Velocity Vector

    Directory of Open Access Journals (Sweden)

    Navia C. E.

    2007-01-01

    Full Text Available A laser diffraction experiment was conducted to study light propagation in air. The experiment is easy to reproduce and it is based on simple optical principles. Two optical sensors (segmented photo-diodes are used for measuring the position of diffracted light spots with a precision better than 0.1 μ m. The goal is to look for signals of anisotropic light propagation as function of the laser beam alignment to the Earth’s motion (solar barycenter motion obtained by COBE. Two raster search techniques have been used. First, a laser beam fixed in the laboratory frame scans in space due to Earth’s rotation. Second, a laser beam mounted on a turntable system scans actively in space by turning the table. The results obtained with both methods show that the course of light rays are affected by the motion of the Earth, and a predominant first order quantity with a Δ c/c = − β (1 + 2 a cos θ signature with ˉ a = − 0.393 ± 0.032 describes well the experimental results. This result differs in amount of 21% from the Special Relativity Theory prediction and that supplies the value of a = − 1 2 (isotropy.

  3. Relatório REVIVE 2011 - Culicídeos e Ixodídeos (excerto): Rede de Vigilância de Vectores

    OpenAIRE

    2011-01-01

    Rede de Vigilância de Vectores: DGS – Divisão de Saúde Ambiental; ARS – Administração Regional de Saúde do Alentejo, Algarve, Centro, Lisboa e Vale do Tejo e Norte; IASAS Madeira; INSA/DDI – Centro de Estudos de Vectores e Doenças Infecciosas Doutor Francisco Cambournac

  4. Serum leptin levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in normal pregnancy and preeclampsia

    Directory of Open Access Journals (Sweden)

    Karádi István

    2011-09-01

    Full Text Available Abstract Objective In this study, we determined circulating levels of C-reactive protein, several cytokines, chemokines, adhesion molecules and angiogenic factors along with those of leptin in healthy non-pregnant and pregnant women and preeclamptic patients, and investigated whether serum leptin levels were related to the clinical characteristics and measured laboratory parameters of the study participants. Methods Sixty preeclamptic patients, 60 healthy pregnant women and 59 healthy non-pregnant women were involved in this case-control study. Levels of leptin and transforming growth factor (TGF-beta1 in maternal sera were assessed by ELISA. Serum levels of interleukin (IL-1beta, IL-1 receptor antagonist (IL-1ra, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p40, IL-12p70, IL-18, interferon (IFN-gamma, tumor necrosis factor (TNF-alpha, interferon-gamma-inducible protein (IP-10, monocyte chemotactic protein (MCP-1, intercellular adhesion molecule (ICAM-1 and vascular cell adhesion molecule (VCAM-1 were determined by multiplex suspension array. Serum C-reactive protein (CRP concentrations were measured by an autoanalyzer. Serum total soluble fms-like tyrosine kinase-1 (sFlt-1 and biologically active placental growth factor (PlGF levels were determined by electrochemiluminescence immunoassay. For statistical analyses, non-parametric methods were applied. Results There were significant differences in most of the measured laboratory parameters among the three study groups except for serum IL-1beta and TGF-beta1 levels. Serum leptin levels were significantly higher in preeclamptic patients and healthy pregnant women than in healthy non-pregnant women. Additionally, preeclamptic patients had significantly higher leptin levels as compared to healthy pregnant women. Serum leptin levels were independently associated with BMI in healthy non-pregnant women. In healthy pregnant women, both BMI and serum CRP concentrations showed significant positive linear

  5. Penalized versions of the Newman-Girvan modularity and their relation to normalized cuts and k-means clustering.

    Science.gov (United States)

    Bolla, Marianna

    2011-07-01

    Two penalized-balanced and normalized-versions of the Newman-Girvan modularity are introduced and estimated by the non-negative eigenvalues of the modularity and normalized modularity matrix, respectively. In this way, the partition of the vertices that maximizes the modularity can be obtained by applying the k-means algorithm for the representatives of the vertices based on the eigenvectors belonging to the largest positive eigenvalues of the modularity or normalized modularity matrix. The proper dimension depends on the number of the structural eigenvalues of positive sign, while dominating negative eigenvalues indicate an anticommunity structure; the balance between the negative and the positive eigenvalues determines whether the underlying graph has a community, anticommunity, or randomlike structure.

  6. Effects of Age, Gender, Bolus Volume, Bolus Viscosity, and Gustation on Swallowing Apnea Onset Relative to Lingual Bolus Propulsion Onset in Normal Adults

    Science.gov (United States)

    Hiss, Susan G.; Strauss, Monica; Treole, Kathleen; Stuart, Andrew; Boutilier, Susan

    2004-01-01

    The purpose of this study was to ascertain the normal relation of swallowing apnea (SA) onset relative to lingual bolus propulsion along with factors that may alter this relation. Forty adults, composed of 10 men and 10 women in each of 2 age groups (i.e., 20-30 and 63-79 years) participated. SA onset was assessed during 5- and 20-ml bolus volumes…

  7. Hospitalization expenses of acute ischemic stroke patients with atrial fibrillation relative to those with normal sinus rhythm.

    Science.gov (United States)

    Li, Jiming; Luo, Weiliang

    2017-02-01

    Atrial fibrillation (AF) is a risk factor for acute ischemic stroke (AIS). In mainland China, little is known of the hospitalization expenses of AIS patients with AF compared to those with normal sinus rhythm (SR). This study compared the itemized expenses of AIS patients with or without AF in a hospital in Huizhou City. Patients hospitalized for AIS from March 2014 to March 2015 were enrolled, including 73 with AF and 751 with normal SR. Stroke severity was scored using the National Institutes of Health Stroke Scale (NIHSS). Non-parametric statistical tests were used to determine differences in hospital expenses between the two groups, of which influencing factors were analyzed using single factor and multiple stepwise linear regression analyses. Medicine was the predominant expense during hospitalization of all AIS patients. Patients with AF incurred significantly higher expenses for medicine, bed, treatments, examinations, laboratory tests, and nursing than patients with normal SR (p expenses of patients at the same stroke level in the two groups were similar. Independent factors influencing the higher costs of AF patients were hospital length of stay, pulmonary infection, urinary-tract infection, NIHSS scoring, gastrointestinal bleeding, and congestive heart failure (p hospital length of stay were NIHSS scoring, pulmonary infection, and urinary-tract infection (p expenses during hospitalization compared with those with normal SR, due to greater stroke severity, higher rates of pulmonary infection and congestive heart failure, and longer hospital stays.

  8. Pre-beta-HDL formation relates to high-normal free thyroxine in type 2 diabetes mellitus

    NARCIS (Netherlands)

    Tienhoven-Wind, van Lynnda; Perton, Frank G.; Dullaart, Robin P. F.

    Objectives: Low-normal thyroid function within the euthyroid range may influence plasma lipoprotein levels. Associations between variation in thyroid function and pre-beta-high density lipoproteins (pre-beta-HDL), i.e. lipid-poor or lipid free HDL particles that act as initial acceptor of

  9. Structural and Metabolic Correlates of Episodic Memory in Relation to the Depth of Encoding in Normal Aging

    Science.gov (United States)

    Kalpouzos, Gregoria; Chetelat, Gael; Landeau, Brigitte; Clochon, Patrice; Viader, Fausto; Eustache, Francis; Desgranges, Beatrice

    2009-01-01

    This study set out to establish the relationship between changes in episodic memory retrieval in normal aging on the one hand and gray matter volume and [superscript 18]FDG uptake on the other. Structural MRI, resting-state [superscript 18]FDG-PET, and an episodic memory task manipulating the depth of encoding and the retention interval were…

  10. Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors.

    Science.gov (United States)

    Trobridge, Grant; Russell, David W

    2004-03-01

    Retroviral vectors based on foamy viruses (FV) are efficient gene delivery vehicles for therapeutic and research applications. While previous studies have shown that FV vectors transduce quiescent cell cultures more efficiently than oncoviral vectors, their specific cell cycle requirements have not been determined. Here we compare the transduction frequencies of FV vectors with those of onco- and lentiviral vectors in nondividing and dividing normal human fibroblasts by several methods. FV vectors transduced serum-deprived fibroblast cultures more efficiently than oncoretroviral vectors and at rates comparable to those of lentiviral vectors. However, in these cultures FV vectors only transduced a subpopulation of proliferating cells, as determined by bromodeoxyuridine staining for DNA synthesis. In contrast to lentiviral vectors, FV vectors were unable to transduce human fibroblasts arrested by aphidicolin (G(1)/S phase) or gamma-irradiation (G(2) phase), and a partial cell cycle that included mitosis but not DNA synthesis was required. We could not determine if mitosis facilitated nuclear entry of FV vectors, since cell-free vector preparations contained long terminal repeat circles, precluding their use as nuclear markers. In contrast to oncoviral vectors, both FV and lentiviral vectors efficiently transduced G(0) fibroblasts that were later stimulated to divide. In the case of FV vectors, this was due to the persistence of a stable transduction intermediate in quiescent cells. Our findings support the use of FV vectors as a safe and effective alternative to lentiviral vectors for ex vivo transduction of stem cells that are quiescent during culture but divide following transplantation.

  11. Antitumor Activity and Prolonged Expression from a TRAIL-Expressing Adenoviral Vector

    Directory of Open Access Journals (Sweden)

    Jeongwu Lee

    2002-01-01

    Full Text Available Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL induces apoptosis in a variety of transformed cell lines, but generally spares most normal cells. Transduction by an adenoviral vector expressing human TRAIL cDNA (Ad.TRAIL-GFP resulted in both direct tumor cell killing as well as a potent bystander effect through presentation of TRAIL by transduced normal cells. Administration of Ad.TRAIL-GFP significantly prolonged survival of mice harboring either intracerebral glioblastomas or breast carcinoma-induced peritoneal carcinomatosis. Additionally, TRAIL induced prolonged transgene expression in normal tissue, presumably as a result of diminished immunemediated destruction of vector-transduced cells. Taken together, these data suggest that vector-mediated transduction of TRAIL may represent an effective strategy for cancer gene therapy.

  12. Mining the bitter melon (momordica charantia l. seed transcriptome by 454 analysis of non-normalized and normalized cDNA populations for conjugated fatty acid metabolism-related genes

    Directory of Open Access Journals (Sweden)

    Shipp Matthew J

    2010-11-01

    Full Text Available Abstract Background Seeds of Momordica charantia (bitter melon produce high levels of eleostearic acid, an unusual conjugated fatty acid with industrial value. Deep sequencing of non-normalized and normalized cDNAs from developing bitter melon seeds was conducted to uncover key genes required for biotechnological transfer of conjugated fatty acid production to existing oilseed crops. It is expected that these studies will also provide basic information regarding the metabolism of other high-value novel fatty acids. Results Deep sequencing using 454 technology with non-normalized and normalized cDNA libraries prepared from bitter melon seeds at 18 DAP resulted in the identification of transcripts for the vast majority of known genes involved in fatty acid and triacylglycerol biosynthesis. The non-normalized library provided a transcriptome profile of the early stage in seed development that highlighted the abundance of transcripts for genes encoding seed storage proteins as well as for a number of genes for lipid metabolism-associated polypeptides, including Δ12 oleic acid desaturases and fatty acid conjugases, class 3 lipases, acyl-carrier protein, and acyl-CoA binding protein. Normalization of cDNA by use of a duplex-specific nuclease method not only increased the overall discovery of genes from developing bitter melon seeds, but also resulted in the identification of 345 contigs with homology to 189 known lipid genes in Arabidopsis. These included candidate genes for eleostearic acid metabolism such as diacylglycerol acyltransferase 1 and 2, and a phospholipid:diacylglycerol acyltransferase 1-related enzyme. Transcripts were also identified for a novel FAD2 gene encoding a functional Δ12 oleic acid desaturase with potential implications for eleostearic acid biosynthesis. Conclusions 454 deep sequencing, particularly with normalized cDNA populations, was an effective method for mining of genes associated with eleostearic acid metabolism in

  13. Population dynamics of pest mosquitoes and potential malaria and West Nile virus vectors in relation to climatic factors and human activities in the Camargue, France.

    Science.gov (United States)

    Ponçon, N; Toty, C; L'ambert, G; le Goff, G; Brengues, C; Schaffner, F; Fontenille, D

    2007-12-01

    The Camargue is an extensive wetland in the southeast of France, which is highly influenced by human activities. Large ponds, marshes and irrigated fields provide abundant potential breeding sites for mosquitoes. mosquitoes, which are important in terms of the nuisance they cause to people and animals, the limitations they impose on tourism and their potential threat to human health. Several of the mosquito species present are potential vectors of malaria and West Nile virus. Therefore, the population dynamics of these species were monitored over an entire breeding season during March-October 2005. Mosquito populations were sampled in two study areas once every 2 weeks, using CDC light traps baited with CO(2). Sixteen species were collected. The majority (98.7%) of the catch were Aedes caspius (Pallas) (Diptera: Culicidae), Culex modestus (Ficalbi), Culex pipiens L. and Anopheles hyrcanus (Pallas). The population dynamics of these species varied considerably in relation to the species' biology, climatic conditions (rainfall, temperature and season), water management, implementation of mosquito control campaigns and landscape use.

  14. Wedge cutting of mild steel by CO 2 laser and cut-quality assessment in relation to normal cutting

    Science.gov (United States)

    Yilbas, B. S.; Karatas, C.; Uslan, I.; Keles, O.; Usta, Y.; Yilbas, Z.; Ahsan, M.

    2008-10-01

    In some applications, laser cutting of wedge surfaces cannot be avoided in sheet metal processing and the quality of the end product defines the applicability of the laser-cutting process in such situations. In the present study, CO 2 laser cutting of the wedge surfaces as well as normal surfaces (normal to laser beam axis) is considered and the end product quality is assessed using the international standards for thermal cutting. The cut surfaces are examined by the optical microscopy and geometric features of the cut edges such as out of flatness and dross height are measured from the micrographs. A neural network is introduced to classify the striation patterns of the cut surfaces. It is found that the dross height and out of flatness are influenced significantly by the laser output power, particularly for wedge-cutting situation. Moreover, the cut quality improves at certain value of the laser power intensity.

  15. Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis

    Science.gov (United States)

    Balandrán, Juan Carlos; Purizaca, Jessica; Enciso, Jennifer; Dozal, David; Sandoval, Antonio; Jiménez-Hernández, Elva; Alemán-Lazarini, Leticia; Perez-Koldenkova, Vadim; Quintela-Núñez del Prado, Henry; Rios de los Ríos, Jussara; Mayani, Héctor; Ortiz-Navarrete, Vianney; Guzman, Monica L.; Pelayo, Rosana

    2017-01-01

    Pediatric oncology, notably childhood acute lymphoblastic leukemia (ALL), is currently one of the health-leading concerns worldwide and a biomedical priority. Decreasing overall leukemia mortality in children requires a comprehensive understanding of its pathobiology. It is becoming clear that malignant cell-to-niche intercommunication and microenvironmental signals that control early cell fate decisions are critical for tumor progression. We show here that the mesenchymal stromal cell component of ALL bone marrow (BM) differ from its normal counterpart in a number of functional properties and may have a key role during leukemic development. A decreased proliferation potential, contrasting with the strong ability of producing pro-inflammatory cytokines and an aberrantly loss of CXCL12 and SCF, suggest that leukemic lymphoid niches in ALL BM are unique and may exclude normal hematopoiesis. Cell competence ex vivo assays within tridimensional coculture structures indicated a growth advantage of leukemic precursor cells and their niche remodeling ability by CXCL12 reduction, resulting in leukemic cell progression at the expense of normal niche-associated lymphopoiesis. PMID:28111575

  16. [Total proteins of the cerebrospinal fluid obtained by punction of the cisterna magna: normal values. Variations related to sex].

    Science.gov (United States)

    Vermes, L M; Ferri, R G; Aisen, J; Marlet, J M

    1976-12-01

    The total protein content of CSF collected from the cisterna magna (cisternal fluid) of 98 patients (58 males and 40 females) with no neurological diseases was determined by the colorimetric method devised by Lowry and co-workers. This method has been previously chosen based mainly on it's sensitivity, accuracy and low fluid consumption. The CSF samples were normal with regard to pressure, color, citology and it's content in glucose, chloride and urea. Complement fixation tests for syphilis and cisticercosis, as well as the globulin tests (Pandy, Nonne--Appelt and Takata-Ara) were negative. The average value and the normal range of cisternal fluid total protein was calculated for the mixed population (males and females). The mean protein value was 26.78 mg/100 ml, the lower and upper limits were respectively 13.20 and 40.36 mg/100 ml. These data are higher than those stated in some publications, and factors that could interfere in the different results mentioned in the literature are briefly discussed. Since the statistical analysis of the results showed that the mean total protein concentration in males (28.76 mg/100 ml) was higher than in females (23.91 mg/100 ml), normal limits for each sex were established: 16.96 to 47.13 mg/100 ml for males and 14.76 to 42.76 mg/100 ml for females.

  17. Multigene phylogenetics reveals temporal diversification of major African malaria vectors.

    Directory of Open Access Journals (Sweden)

    Maryam Kamali

    Full Text Available The major vectors of malaria in sub-Saharan Africa belong to subgenus Cellia. Yet, phylogenetic relationships and temporal diversification among African mosquito species have not been unambiguously determined. Knowledge about vector evolutionary history is crucial for correct interpretation of genetic changes identified through comparative genomics analyses. In this study, we estimated a molecular phylogeny using 49 gene sequences for the African malaria vectors An. gambiae, An. funestus, An. nili, the Asian malaria mosquito An. stephensi, and the outgroup species Culex quinquefasciatus and Aedes aegypti. To infer the phylogeny, we identified orthologous sequences uniformly distributed approximately every 5 Mb in the five chromosomal arms. The sequences were aligned and the phylogenetic trees were inferred using maximum likelihood and neighbor-joining methods. Bayesian molecular dating using a relaxed log normal model was used to infer divergence times. Trees from individual genes agreed with each other, placing An. nili as a basal clade that diversified from the studied malaria mosquito species 47.6 million years ago (mya. Other African malaria vectors originated more recently, and independently acquired traits related to vectorial capacity. The lineage leading to An. gambiae diverged 30.4 mya, while the African vector An. funestus and the Asian vector An. stephensi were the most closely related sister taxa that split 20.8 mya. These results were supported by consistently high bootstrap values in concatenated phylogenetic trees generated individually for each chromosomal arm. Genome-wide multigene phylogenetic analysis is a useful approach for discerning historic relationships among malaria vectors, providing a framework for the correct interpretation of genomic changes across species, and comprehending the evolutionary origins of this ubiquitous and deadly insect-borne disease.

  18. Atomic Parity Violation, Muon Pair Production in e+e - Collisions and Detection of CDM WIMP-Physics Related to Neutral Vector Boson D1

    Science.gov (United States)

    Senju, H.

    1999-11-01

    In our preon model there exists a neutral vector boson D1 which is an isoscalar partner of W(Z) in the vector boson octet. It is shown that the exchange of a D1 of about 1 TeV mass naturally explains a positive excess of the weak charge of atomic cesium recently observed. Other processes occurring through the D1 exchange are discussed, including the detection of CDM WIMP.

  19. Normal values of posterior antebrachial cutaneous nerve conduction study related to age, gender, height, and body mass index.

    Science.gov (United States)

    Sajadi, Simin; Mansoori, Korosh; Raissi, Gholam R; Emami Razavi, Seyede Z; Ghajarzadeh, Mahsa

    2014-12-01

    Recent studies have proposed posterior antebrachial cutaneous (PABC) nerve could help in interpretation of some conditions in upper limb electrodiagnostic study. This study aimed to establish these normal values and to assess the effect of sex, age, height, and body mass index on these normal values. Eligible participants were 84 healthy adult people aged between 22 and 75 years who underwent PABC nerve conduction studies. The mean ± SD values of the base-to-peak amplitude, peak latency, and nerve conduction velocity of all participants were 10.95 ± 2.90 μV, 2.08 ± 0.20 milliseconds, and 57.85 ± 7.83 m/second, respectively. There was a significant positive correlation between the subjects' age and the PABC onset latency, peak latency, and nerve conduction velocity (r = 0.64, P < 0.001; r = 0.6, P < 0.001; and r = 0.44, P < 0.001, respectively). A significant negative correlation was observed between age and base-to-peak amplitude and peak-to-peak amplitude of participants, as well (r = -0.38, r = -0.41, P < 0.001, respectively). The correlation of body mass index with base-to-peak amplitude and peak-to-peak amplitude were r = -0.36, P < 0.001 and r = -0.40, P < 0.001, respectively. This study has established normal values for PABC nerve conduction studies. Furthermore, age and body mass index must be taken into account for making diagnostic conclusion in PABC nerve conduction studies.

  20. Relative activity of cerebral subcortical gray matter in varying states of attention and awareness in normal subjects and patient studies

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, M.; Chen, C.T.; Levy, J.; Wagner, N.; Spire, J.P.; Jacobsen, J.; Meltzer, H.; Metz, J.; Beck, R.N.

    1985-05-01

    An important aspect of the study of brain function involves measurement of the relationships; between activities in the subcortical gray matter of the caudate and of the thalamus; and between these structures and functional cortical areas. The authors have studied these relationships in 22 subjects under different conditions of activation, sleep and sensory deprivation using a PET VI system and F-18-2DG to determine regional cerebral metabolism. Subject activating conditions were maintained throughout the period of equilibration of F-18-2DG and E.E.G.'s were monitored. Multiple tomographic slices of 1-2 million counts were obtained simultaneously with slice separation of 14mm and each plane parallel to the cantho-meatal line. In activated and non-activated awake conditions for normal subjects, left and right thalmus-to-caudate ratios were similar and greater than unity. This relationship was maintained in non-REM sleep, but was reversed and divergent in REM sleep and sensory deprivation; this was also evident in 3/4 narcoleptics awake and asleep in non-REM and REM and 2/3 schizophrenics and affective disorder, subjects. This approach appears to have potential for characterizating normal and disordered regional cerebral function.

  1. Analysis of Systolic Backflow and Secondary Helical Blood Flow in the Ascending Aorta Using Vector Flow Imaging

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Lindskov; Møller-Sørensen, Hasse; Kjaergaard, Jesper

    2016-01-01

    Secondary rotational flow and systolic backflow are seen in the ascending aorta and, in this study, were analyzed with the vector velocity method transverse oscillation. Twenty-five patients were scanned intra-operatively, and the vector velocities were related to estimates of transesophageal...... that backflow is injurious and that secondary flow is a normal flow phenomenon. The study also shows that transverse oscillation can provide new information on blood flow in the ascending aorta....

  2. Switching of G-protein Usage by the Calcium-sensing Receptor Reverses Its Effect on Parathyroid Hormone-related Protein Secretion in Normal Versus Malignant Breast Cells*

    OpenAIRE

    Mamillapalli, Ramanaiah; VanHouten, Joshua; Zawalich, Walter; Wysolmerski, John

    2008-01-01

    The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that signals in response to extracellular calcium and regulates parathyroid hormone secretion. The CaR is also expressed on normal mammary epithelial cells (MMECs), where it has been shown to inhibit secretion of parathyroid hormone-related protein (PTHrP) and participate in the regulation of calcium and bone metabolism during lactation. In contrast to normal breast cells, the CaR has been reported to s...

  3. Problems and worked solutions in vector analysis

    CERN Document Server

    Shorter, LR

    2014-01-01

    ""A handy book like this,"" noted The Mathematical Gazette, ""will fill a great want."" Devoted to fully worked out examples, this unique text constitutes a self-contained introductory course in vector analysis for undergraduate and graduate students of applied mathematics.Opening chapters define vector addition and subtraction, show how to resolve and determine the direction of two or more vectors, and explain systems of coordinates, vector equations of a plane and straight line, relative velocity and acceleration, and infinitely small vectors. The following chapters deal with scalar and vect

  4. BENTUK NORMAL SMITH DAN MATRIKS BAIK KIRI/KANAN

    Directory of Open Access Journals (Sweden)

    Yumiati Yumiati

    2016-09-01

    Full Text Available The Smith normal form and left good matrix have been known in matrix theorem. Any matrix over the principal ideal ring has a Smith normal form. The Smith normal form of a matrix has many applications on various fields such as a solution of Diophantin linear equation and differential equation system. Furthermore, a matrix A with entries in a commutative ring R with unity is left good if for every vector x, the ideal áxAñ is the same as the ideal áAñ. This paper discusses the relation between the Smith normal form and left good matrix. The relation is as the following: matrix A with entries in principal ideal ring of size m by n, with m < n, has Smith normal form [Im, O] if only if A is a left good matrix.

  5. Therapeutic and prophylactic applications of alphavirus vectors.

    Science.gov (United States)

    Atkins, Gregory J; Fleeton, Marina N; Sheahan, Brian J

    2008-11-11

    Alphavirus vectors are high-level, transient expression vectors for therapeutic and prophylactic use. These positive-stranded RNA vectors, derived from Semliki Forest virus, Sindbis virus and Venezuelan equine encephalitis virus, multiply and are expressed in the cytoplasm of most vertebrate cells, including human cells. Part of the genome encoding the structural protein genes, which is amplified during a normal infection, is replaced by a transgene. Three types of vector have been developed: virus-like particles, layered DNA-RNA vectors and replication-competent vectors. Virus-like particles contain replicon RNA that is defective since it contains a cloned gene in place of the structural protein genes, and thus are able to undergo only one cycle of expression. They are produced by transfection of vector RNA, and helper RNAs encoding the structural proteins. Layered DNA-RNA vectors express the Semliki Forest virus replicon from a cDNA copy via a cytomegalovirus promoter. Replication-competent vectors contain a transgene in addition to the structural protein genes. Alphavirus vectors are used for three main applications: vaccine construction, therapy of central nervous system disease, and cancer therapy.

  6. Comparative study of serum uric acid levels in preeclamptic and normal pregnant women and its related outcomes

    Directory of Open Access Journals (Sweden)

    M. Fakhri

    2005-01-01

    Full Text Available Background and purpose: Preeclampsia is a hypertensive disorder in pregnancy and is known as a specific syndrom of pregnancy. Several studies have been done to asses the indicators of preeclampsia for early detection of the disease. Uric acid is considered by some investigators as one of the most sensetive indicators in preeclampsia. In contrast some researchers have found it not useful in prediction of preeclampsia. Hence, more studies are needed about the role of uric acid levels in diagnosis of preeclampsia. The aim of this research is to compare the serum uric acid levels in preeclamptic and normal pregnant women and its sensivity as an indicator of preeclampsia.Materials and methods : In this case-control study 304 pregnant women were enrolled in the study at Fatmeh Zahrah Hospital of Sari. Among them, 151 preeclamptic women were allocated in case group and 153 healthy pregnant women in control group. SPSS were used for analysis of data and variables were compared by Chi square, ANOVA, Pearson correlation index, and sensivity and specifity were calculated.Results : Difference in the number of term delivery and primi gravidity between the three groups (normal, mild and severe preeclampsia were significant (P<0.05. Considering maternal and fetal outcomes, only Decolman (two cases had no significant difference between 3 groups.Mean of uric acid levels differed between three groups (P<0.0001. Severe preeclampsia had the most significant difference with normal group. Elevated uric acid (defined as up of 5.5 mg/dl was observed in 34/2% in hyperuricemia group, 71.2 % in preeclamtic and 28.8% in control group (P<0.0001 The sensivity of uric acid levels for determining the preeclampsia and its severity elevated with increasing in concentration of uric acid but the specifity decreased.Conclusion : Results showed that the sensivity of uric acid levels in diagnosis of preeclampsia is moderate and measuring uric acid can be used in determining the

  7. Rotations with Rodrigues' Vector

    Science.gov (United States)

    Pina, E.

    2011-01-01

    The rotational dynamics was studied from the point of view of Rodrigues' vector. This vector is defined here by its connection with other forms of parametrization of the rotation matrix. The rotation matrix was expressed in terms of this vector. The angular velocity was computed using the components of Rodrigues' vector as coordinates. It appears…

  8. Empirical relations to determine the normalized spot size of a single-mode trapezoidal index fiber and computation of its propagation characteristics

    Science.gov (United States)

    Mallick, Aswini Kumar; Sarkar, Somenath

    2014-07-01

    Simple and complete empirical relations are presented here to determine a normalized spot size in terms of normalized frequencies over a long range and aspect ratio of a trapezoidal index single-mode fiber considering Gaussian approximation of the fundamental mode following the Marcuse method for the first time. After verification of their validity for arbitrary values of aspect ratio and normalized frequency, we calculate various propagation characteristics viz. dispersion and splice loss by using our formulations. Upon comparison, we observe an excellent match and the validity of our results with exact values and other results available in the literature. These formulas should attract the attention of experimentalists as a simple alternative to the rigorous methods of estimating the propagation characteristics of such fibers.

  9. Stylet morphometrics and citrus leaf vein structure in relation to feeding behavior of the Asian citrus psyllid Diaphorina citri, vector of citrus huanglongbing bacterium.

    Science.gov (United States)

    Ammar, El-Desouky; Hall, David G; Shatters, Robert G

    2013-01-01

    The Asian citrus psyllid (ACP), Diaphorina citri (Hemiptera: Psyllidae), is the primary vector of the phloem-limited bacterium Candidatus Liberibacter asiaticus (LAS) associated with huanglongbing (HLB, citrus greening), considered the world's most serious disease of citrus. Stylet morphometrics of ACP nymphs and adults were studied in relation to citrus vein structure and to their putative (histologically verified) feeding sites on Valencia orange leaves. ACP nymphs preferred to settle and feed on the lower (abaxial) side of young leaves either on secondary veins or on the sides of the midrib, whereas adults preferred to settle and feed on the upper (adaxial) or lower secondary veins of young or old leaves. Early instar nymphs can reach and probe the phloem probably because the distance to the phloem is considerably shorter in younger than in mature leaves, and is shorter from the sides of the midrib compared to that from the center. Additionally, the thick-walled 'fibrous ring' (sclerenchyma) around the phloem, which may act as a barrier to ACP stylet penetration into the phloem, is more prominent in older than in younger leaves and in the center than on the sides of the midrib. The majority (80-90%) of the salivary sheath termini produced by ACP nymphs and adults that reached a vascular bundle were associated with the phloem, whereas only 10-20% were associated with xylem vessels. Ultrastructural studies on ACP stylets and LAS-infected leaves suggested that the width of the maxillary food canal in first instar nymphs is wide enough for LAS bacteria to traverse during food ingestion (and LAS acquisition). However, the width of the maxillary salivary canal in these nymphs may not be wide enough to accommodate LAS bacteria during salivation (and LAS inoculation) into host plants. This may explain the inability of early instar nymphs to transmit LAS/HLB in earlier reports.

  10. Isolation, cloning, and expression mapping of a gene encoding an antidiuretic hormone and other CAPA-related peptides in the disease vector, Rhodnius prolixus.

    Science.gov (United States)

    Paluzzi, Jean-Paul; Russell, William K; Nachman, Ronald J; Orchard, Ian

    2008-09-01

    After a blood meal, Rhodnius prolixus undergoes a rapid diuresis to eliminate excess water and salts. During the voiding of this primary urine, R. prolixus acts as a vector of Chagas' disease, with the causative agent, Trypanosoma cruzi, infecting the human host via the urine. Diuresis in R. prolixus is under the neurohormonal control of serotonin and peptidergic diuretic hormones, and thus, diuretic hormones play an important role in the transmission of Chagas' disease. Although diuretic hormones may be degraded or excreted, resulting in the termination of diuresis, it would also seem appropriate, given the high rates of secretion, that a potent antidiuretic factor could be present and act to prevent excessive loss of water and salts after the postgorging diuresis. Despite the medical importance of R. prolixus, no genes for any neuropeptides have been cloned, including obviously, those that control diuresis. Here, using molecular biology in combination with matrix-assisted laser desorption ionization-time of flight-tandem mass spectrometry, we determined the sequence of the CAPA gene and CAPA-related peptides in R. prolixus, which includes a peptide with anti-diuretic activity. We have characterized the expression of mRNA encoding these peptides in various developmental stage and also examined the tissue-specific distribution in fifth-instars. The expression is localized to numerous bilaterally paired cell bodies within the central nervous system. In addition, our results show that RhoprCAPA gene expression is also associated with the testes, suggesting a novel role for this family of peptides in reproduction.

  11. Stylet morphometrics and citrus leaf vein structure in relation to feeding behavior of the Asian citrus psyllid Diaphorina citri, vector of citrus huanglongbing bacterium.

    Directory of Open Access Journals (Sweden)

    El-Desouky Ammar

    Full Text Available The Asian citrus psyllid (ACP, Diaphorina citri (Hemiptera: Psyllidae, is the primary vector of the phloem-limited bacterium Candidatus Liberibacter asiaticus (LAS associated with huanglongbing (HLB, citrus greening, considered the world's most serious disease of citrus. Stylet morphometrics of ACP nymphs and adults were studied in relation to citrus vein structure and to their putative (histologically verified feeding sites on Valencia orange leaves. ACP nymphs preferred to settle and feed on the lower (abaxial side of young leaves either on secondary veins or on the sides of the midrib, whereas adults preferred to settle and feed on the upper (adaxial or lower secondary veins of young or old leaves. Early instar nymphs can reach and probe the phloem probably because the distance to the phloem is considerably shorter in younger than in mature leaves, and is shorter from the sides of the midrib compared to that from the center. Additionally, the thick-walled 'fibrous ring' (sclerenchyma around the phloem, which may act as a barrier to ACP stylet penetration into the phloem, is more prominent in older than in younger leaves and in the center than on the sides of the midrib. The majority (80-90% of the salivary sheath termini produced by ACP nymphs and adults that reached a vascular bundle were associated with the phloem, whereas only 10-20% were associated with xylem vessels. Ultrastructural studies on ACP stylets and LAS-infected leaves suggested that the width of the maxillary food canal in first instar nymphs is wide enough for LAS bacteria to traverse during food ingestion (and LAS acquisition. However, the width of the maxillary salivary canal in these nymphs may not be wide enough to accommodate LAS bacteria during salivation (and LAS inoculation into host plants. This may explain the inability of early instar nymphs to transmit LAS/HLB in earlier reports.

  12. Clarifying Normalization

    Science.gov (United States)

    Carpenter, Donald A.

    2008-01-01

    Confusion exists among database textbooks as to the goal of normalization as well as to which normal form a designer should aspire. This article discusses such discrepancies with the intention of simplifying normalization for both teacher and student. This author's industry and classroom experiences indicate such simplification yields quicker…

  13. The use of normalized climatological anomalies to rank synoptic-scale events and their relation to Weather Types

    Science.gov (United States)

    Ramos, A. M.; Lorenzo, M. N.; Gimeno, L.; Nieto, R.; Añel, J. A.

    2009-09-01

    Several methods have been developed to rank meteorological events in terms of severity, social impact or economic impacts. These classifications are not always objective since they depend of several factors, for instance, the observation network is biased towards the densely populated urban areas against rural or oceanic areas. It is also very important to note that not all rare synoptic-scale meteorological events attract significant media attention. In this work we use a comprehensive method of classifying synoptic-scale events adapted from Hart and Grumm, 2001, to the European region (30N-60N, 30W-15E). The main motivation behind this method is that the more unusual the event (a cold outbreak, a heat wave, or a flood), for a given region, the higher ranked it must be. To do so, we use four basic meteorological variables (Height, Temperature, Wind and Specific Humidity) from NCEP reanalysis dataset over the range of 1000hPa to 200hPa at a daily basis from 1948 to 2004. The climatology used embraces the 1961-1990 period. For each variable, the analysis of raking climatological anomalies was computed taking into account the daily normalized departure from climatology at different levels. For each day (from 1948 to 2004) we have four anomaly measures, one for each variable, and another, a combined where the anomaly (total anomaly) is the average of the anomaly of the four variables. Results will be analyzed on a monthly, seasonal and annual basis. Seasonal trends and variability will also be shown. In addition, and given the extent of the database, the expected return periods associated with the anomalies are revealed. Moreover, we also use an automated version of the Lamb weather type (WT) classification scheme (Jones et al, 1993) adapted for the Galicia area (Northwestern corner of the Iberian Peninsula) by Lorenzo et al (2008) in order to compute the daily local circulation regimes in this area. By combining the corresponding daily WT with the five anomaly

  14. Inverse Operation of Four-dimensional Vector Matrix

    Directory of Open Access Journals (Sweden)

    H J Bao

    2011-08-01

    Full Text Available This is a new series of study to define and prove multidimensional vector matrix mathematics, which includes four-dimensional vector matrix determinant, four-dimensional vector matrix inverse and related properties. There are innovative concepts of multi-dimensional vector matrix mathematics created by authors with numerous applications in engineering, math, video conferencing, 3D TV, and other fields.

  15. [Measuring health-related quality of life with the SF-8. Normal sample of the German population].

    Science.gov (United States)

    Ellert, U; Lampert, T; Ravens-Sieberer, U

    2005-12-01

    The SF-8, a relatively new instrument for measuring health-related quality of life, was used in the German National Telephone Health Survey 2003. The SF-8 provides results which are comparable to those of the SF-36, the instrument most commonly used internationally. The German National Telephone Health Survey provides nationally representative data for the residential population in Germany aged 18 and older. In addition to the measurement of health-related quality of life, comprehensive information on chronic illnesses and complaints, health care needs, utilisation of health care, risk factors, risk behaviour and social status is also collected, making differentiated analyses possible. According to the data collected, men rate their quality of life in all dimensions higher than women. With increasing age, quality of life for both men and women decreases in the physical dimensions, while increasing in the mental health dimensions. Apart from chronic disease and pain having a negative impact on health-related quality of life, social differences are also observable, in that worse health-related quality of life is reported by respondents with lower socioeconomic status.

  16. Cytotoxic, genotoxic and apoptotic effects of naringenin-oxime relative to naringenin on normal and cancer cell lines

    Institute of Scientific and Technical Information of China (English)

    Abdurrahim Kocyigit; Ismail Koyuncu; Murat Dikilitas; Fatemeh Bahadori; Baki Turkkan

    2016-01-01

    Objective: To assess and compare the cytotoxic, genotoxic, apoptotic and reactive oxygen species (ROS) generating effects of naringenin (NG) and its new derived compound naringenin-oxime (NG-Ox) on MCF-7, HT-29, PC-12 cancer and L-929 normal cell lines. Methods: The cells were incubated with different doses of NG-Ox and NG (50–1 000 mmol/L) for 24 h. The cell viability was assessed based on ATP cell viability assay. Intracellular accumulation of ROS was determined using the fluorescent probes 2070-dichlorodihydrofluorescin diacetate. Genotoxic effects were evaluated by alkaline single cell gel electrophoresis assay (comet assay) and, the apoptotic effect was evaluated by acridine orange staining at below the IC50 levels. Results: Both NG-Ox and NG exhibited cytotoxic, genotoxic and apoptotic effects and resulted in increased ROS values in a dose-dependent manner. The effects were more pronounced on cancer cell lines. The cytotoxic, genotoxic and apoptotic effects of NG-Ox were higher than that of NG in all cell lines. Significant correlations were observed be-tween cell viability, DNA damage, apoptosis and ROS, in all cell lines exposed to either NG-Ox or NG. Conclusions: This study showed that both NG-Ox and NG possess cytotoxic, genotoxic and apoptotic activities through the production of ROS on cells, NG-Ox being the more effective one. Therefore, derived compound of NG might be used as antiproliferative agents for the treatment of cancer.

  17. CSF monoamine metabolites, cholinesterases and lactate in the adult hydrocephalus syndrome (normal pressure hydrocephalus) related to CSF hydrodynamic parameters.

    Science.gov (United States)

    Malm, J; Kristensen, B; Ekstedt, J; Adolfsson, R; Wester, P

    1991-03-01

    Monoamine metabolites, cholinesterases and lactic acid in lumbar cerebrospinal fluid (CSF) were investigated on patients with the adult hydrocephalus syndrome (idiopathic normal pressure syndrome; AHS, n = 15), Alzheimer's disease (AD, n = 14), multi-infarct dementia (MID, n = 13) and controls (n = 21). Patients had clinical and CSF hydrodynamic investigations. Monoamine concentrations were determined by reversed-phase liquid chromatography, cholinesterases and lactate were determined photometrically. In the AHS patients, CSF monoamine concentrations were not significantly different compared with controls, AD or MID patients. AHS and AD patients showed a similar reduction of CSF acetylcholinesterase activity compared with controls. Positive correlations were found in concentrations of CSF homovanillic acid, CSF 5-hydroxyindoleacetic acid and CSF lactic acid versus CSF outflow conductance (that is, resistance against CSF outflow) in the AHS patients. A similar pattern was observed in a subgroup of MID patients characterised by dilated ventricles and disturbed CSF hydrodynamics. These data suggest that a low CSF outflow conductance may facilitate the clearance of acidic substances from the arachnoid space at the probenecid sensitive active transport site. Alternative explanations would be that a pathologically low CSF outflow conductance is accompanied by an inverse caudorostral flow of CSF or a compromised trans-ependymal diffusion.

  18. Do malaria vector control measures impact disease-related behaviour and knowledge? Evidence from a large-scale larviciding intervention in Tanzania.

    Science.gov (United States)

    Maheu-Giroux, Mathieu; Castro, Marcia C

    2013-11-15

    Recent efforts of accelerated malaria control towards the long-term goal of elimination had significant impacts in reducing malaria transmission. While these efforts need to be sustained over time, a scenario of low transmission could bring about changes in individual disease risk perception, hindering adherence to protective measures, and affecting disease-related knowledge. The goal of this study was to investigate the potential impact of a successful malaria vector control intervention on bed net usage and malaria-related knowledge. Dar es Salaam's Urban Malaria Control Program was launched in 2004 with the aim of developing a sustainable larviciding intervention. Larviciding was scaled-up using a stepped-wedge design. Cross-sectional and longitudinal data were collected using a randomized cluster sampling design (2004-2008). Prevalence ratios (PR) for the effect of the larviciding intervention on bed net usage (N = 64,537) and household heads' knowledge of malaria symptoms and transmission (N = 11,254) were obtained from random effects regression models. The probability that individuals targeted by larviciding had used a bed net was reduced by 5% as compared to those in non-intervention areas (PR = 0.95; 95% credible intervals (CrI): 0.94-0.97) and the magnitude of this effect increased with time. Larviciding also led to a decline in household heads' knowledge of malaria symptoms (PR = 0.88; 95% CrI: 0.83-0.92) but no evidence of effect on knowledge of malaria transmission was found. Successful control interventions could bring about further challenges to sustaining gains in reducing malaria transmission if not accompanied by strategies to avoid changes in individual knowledge and behaviour. This study points to two major research gaps. First, there is an urgent need to gather more evidence on the extent to which countries that have achieved significant decline in malaria transmission are also observing changes in individual behaviour and knowledge. Second

  19. Cortical fMRI activation to opponents' body kinematics in sport-related anticipation: expert-novice differences with normal and point-light video.

    Science.gov (United States)

    Wright, M J; Bishop, D T; Jackson, R C; Abernethy, B

    2011-08-18

    Badminton players of varying skill levels viewed normal and point-light video clips of opponents striking the shuttle towards the viewer; their task was to predict in which quadrant of the court the shuttle would land. In a whole-brain fMRI analysis we identified bilateral cortical networks sensitive to the anticipation task relative to control stimuli. This network is more extensive and localised than previously reported. Voxel clusters responding more strongly in experts than novices were associated with all task-sensitive areas, whereas voxels responding more strongly in novices were found outside these areas. Task-sensitive areas for normal and point-light video were very similar, whereas early visual areas responded differentially, indicating the primacy of kinematic information for sport-related anticipation.

  20. Systematic review with meta-analysis: Dietary adherence influences normalization of health-related quality of life in coeliac disease

    NARCIS (Netherlands)

    Burger, J.P.; Brouwer, B. de; Hout, J. in't; Wahab, P.J.; Tummers, M.J.; Drenth, J.P.H.

    2017-01-01

    BACKGROUND & AIMS: Gluten-free diet is the keystone of coeliac disease treatment. Despite adherence, some patients continue to suffer from symptoms that negatively influence health-related quality of life (HRQoL). Therefore we performed a systematic review and meta-analysis to assess the effect of

  1. Comparison of angiogenesis-related factor expression in primary tumor cultures under normal and hypoxic growth conditions

    Directory of Open Access Journals (Sweden)

    Brower Stacey L

    2008-07-01

    Full Text Available Abstract Background A localized hypoxic environment occurs during tumor growth necessitating an angiogenic response or tumor necrosis results. Novel cancer treatment strategies take advantage of tumor-induced vascularisation by combining standard chemotherapeutic agents with angiogenesis-inhibiting agents. This has extended the progression-free interval and prolonged survival in patients with various types of cancer. We postulated that the expression levels of angiogenesis-related proteins from various primary tumor cultures would be greater under hypoxic conditions than under normoxia. Methods Fifty cell sources, including both immortalized cell lines and primary carcinoma cells, were incubated under normoxic conditions for 48 hours. Then, cells were either transferred to a hypoxic environment (1% O2 or maintained at normoxic conditions for an additional 48 hours. Cell culture media from both conditions was collected and analyzed via an ELISA-based assay to determine expression levels of 11 angiogenesis-related factors: VEGF, PDGF-AA, PDGF-AA/BB, IL-8, bFGF/FGF-2, EGF, IP-10/CXCL10, Flt-3 ligand, TGF-β1, TGF-β2, and TGF-β3. Results A linear correlation between normoxic and hypoxic growth conditions exists for expression levels of eight of eleven angiogenesis-related proteins tested including: VEGF, IL-8, PDGF-AA, PDGF-AA/BB, TGF-β1, TGF-β2, EGF, and IP-10. For VEGF, the target of current therapies, this correlation between hypoxia and higher cytokine levels was greater in primary breast and lung carcinoma cells than in ovarian carcinoma cells or tumor cell lines. Of interest, patient cell isolates differed in the precise pattern of elevated cytokines. Conclusion As linear correlations exist between expression levels of angiogenic factors under normoxic and hypoxic conditions in vitro, we propose that explanted primary cells may be used to probe the in vivo hypoxic environment. Furthermore, differential expression levels for each sample

  2. 与广义Baouendi-Grushin向量场相联系的Hardy不等式及其应用%Hardy Inequalities and Applications Related to Generalized Baouendi-Grushin Vector Fields

    Institute of Scientific and Technical Information of China (English)

    窦井波; 钮鹏程

    2008-01-01

    本文建立一类与广义Baouendi-Grushin向量场联系的Hardy不等式.采用的技巧是延伸欧氏空间上的散度定理推出的基本积分不等式和选定适当的向量场.Hardy不等式相应的最佳常数也得到证明.本文结果包括了已有广义Baouendi-Grushin向量场的Hardy不等式.作为应用,讨论了由Baouendi-Grushin向量场构成-退化次椭圆算子的一些性质和刻画了这类向量场构成的非线性算子的一个正解.%In this paper we establish a class of Hardy inequalities related to the gen- eralized Baouendi-Grushin vector fields from another view. Our technique is based on an extension of an elementary integral inequality in the Euclidean space by the generalized di- vergence theorem, and then the choice of suitable vector fields. The best constant is also discussed. Our results contain the well known Hardy inequalities for the class of vector fields. As immediate consequences, we discuss some properties for p-degenerate subelliptic opera- tor and characterize a positive solutions of the nonlinear operator constructed by generalized Baouendi-Grnshin vector fields.

  3. Concise vector analysis

    CERN Document Server

    Eliezer, C J; Maxwell, E A; Sneddon, I N

    1963-01-01

    Concise Vector Analysis is a five-chapter introductory account of the methods and techniques of vector analysis. These methods are indispensable tools in mathematics, physics, and engineering. The book is based on lectures given by the author in the University of Ceylon.The first two chapters deal with vector algebra. These chapters particularly present the addition, representation, and resolution of vectors. The next two chapters examine the various aspects and specificities of vector calculus. The last chapter looks into some standard applications of vector algebra and calculus.This book wil

  4. Light axial vector mesons

    CERN Document Server

    Chen, Kan; Liu, Xiang; Matsuki, Takayuki

    2015-01-01

    Inspired by the abundant experimental observation of axial vector states, we study whether the observed axial vector states can be categorized into the conventional axial vector meson family. In this paper we carry out analysis based on the mass spectra and two-body Okubo-Zweig-Iizuka-allowed decays. Besides testing the possible axial vector meson assignments, we also predict abundant information for their decays and the properties of some missing axial vector mesons, which are valuable to further experimental exploration of the observed and predicted axial vector mesons.

  5. New sequence-based data on the relative DNA contents of chromosomes in the normal male and female human diploid genomes for radiation molecular cytogenetics

    Directory of Open Access Journals (Sweden)

    Repin Mikhail V

    2009-06-01

    Full Text Available Abstract Background The objective of this work is to obtain the correct relative DNA contents of chromosomes in the normal male and female human diploid genomes for the use at FISH analysis of radiation-induced chromosome aberrations. Results The relative DNA contents of chromosomes in the male and female human diploid genomes have been calculated from the publicly available international Human Genome Project data. New sequence-based data on the relative DNA contents of human chromosomes were compared with the data recommended by the International Atomic Energy Agency in 2001. The differences in the values of the relative DNA contents of chromosomes obtained by using different approaches for 15 human chromosomes, mainly for large chromosomes, were below 2%. For the chromosomes 13, 17, 20 and 22 the differences were above 5%. Conclusion New sequence-based data on the relative DNA contents of chromosomes in the normal male and female human diploid genomes were obtained. This approach, based on the genome sequence, can be recommended for the use in radiation molecular cytogenetics.

  6. 3j Symbols: To Normalize or Not to Normalize?

    Science.gov (United States)

    van Veenendaal, Michel

    2011-01-01

    The systematic use of alternative normalization constants for 3j symbols can lead to a more natural expression of quantities, such as vector products and spherical tensor operators. The redefined coupling constants directly equate tensor products to the inner and outer products without any additional square roots. The approach is extended to…

  7. Modeling/GIS, Risk Assessment, Economic Impact: Seasonal Patterns for Entomological Measures of Risk for Exposure to Culex Vectors and West Nile Virus in Relation to Human Disease Cases in Northeastern Colorado

    OpenAIRE

    Bolling, Bethany G.; Barker, Christopher M.; Moore, Chester G.; Pape, W. John; Eisen, Lars

    2009-01-01

    We examined seasonal patterns for entomological measures of risk for exposure to Culex vectors and West Nile virus (family Flaviviridae, genus Flavivirus, WNV) in relation to human WNV disease cases in a five-county area of northeastern Colorado during 2006–2007. Studies along habitat/elevation gradients in 2006 showed that the seasonal activity period is shortened and peak numbers occur later in the summer for Culex tarsalis Coquillett females in foothills-montane areas >1,600 m compared wit...

  8. VectorBase

    Data.gov (United States)

    U.S. Department of Health & Human Services — VectorBase is a Bioinformatics Resource Center for invertebrate vectors. It is one of four Bioinformatics Resource Centers funded by NIAID to provide web-based...

  9. The search for true sources of TBEV and related pathogens : the danger of professed beliefs on pathogens, host and vector interplays

    OpenAIRE

    Gurung, Deepa

    2016-01-01

    Tick-borne disease in general is among the most important vector-borne diseases that are emerging as a threat to humans and is currently identified as a major health problem in many countries. Tick-borne encephalitis and lyme borreliosis are the main diseases transmitted by Ixodes ricinus ticks in Europe. Besides TBEV (Tick-borne encephalitis virus) and Borrelia burgdorferi sensu lato, I. ricinus is known to transmit other pathogenic microorganisms like- louping ill virus, Anaplasma phagocyto...

  10. Age-related changes in BDNF protein levels in human serum: differences between autism cases and normal controls.

    Science.gov (United States)

    Katoh-Semba, Ritsuko; Wakako, Rie; Komori, Taku; Shigemi, Hiroko; Miyazaki, Noriko; Ito, Hironori; Kumagai, Toshiyuki; Tsuzuki, Masako; Shigemi, Kenji; Yoshida, Futoshi; Nakayama, Atsuo

    2007-10-01

    Accumulating evidence suggests the possible association between the concentrations of serum brain-derived neurotrophic factor (BDNF) and psychiatric disease with impaired brain development. Yet the reasons remain unclear. We therefore investigated the characteristics of serum BDNF as well as its age-related changes in healthy controls in comparison to autism cases. BDNF was gradually released from platelets at 4 degrees C, reached a maximal concentration after around 24 h, and remained stable until 42 h. At room temperature, BDNF was found to be immediately degraded. Circadian changes, but not seasonal changes, were found in serum levels of BDNF existing as the mature form with a molecular mass of 14 kDa. In healthy controls, the serum BDNF concentration increased over the first several years, then slightly decreased after reaching the adult level. There were no sex differences between males and females. In the autism cases, mean levels were significantly lower in children 0-9 years old compared to teenagers or adults, or to age-matched healthy controls, indicating a delayed BDNF increase with development. In a separate study of adult rats, a circadian change in serum BDNF was found to be similar to that in the cortex, indicating a possible association with cortical functions.

  11. Birkhoff normalization

    NARCIS (Netherlands)

    Broer, H.; Hoveijn, I.; Lunter, G.; Vegter, G.

    2003-01-01

    The Birkhoff normal form procedure is a widely used tool for approximating a Hamiltonian systems by a simpler one. This chapter starts out with an introduction to Hamiltonian mechanics, followed by an explanation of the Birkhoff normal form procedure. Finally we discuss several algorithms for comput

  12. Perceived and desired weight, weight related eating and exercising behaviours, and advice received from parents among thin, overweight, obese or normal weight Australian children and adolescents.

    Science.gov (United States)

    O'Dea, Jennifer A; Amy, Nancy K

    2011-06-26

    Thin children are less muscular, weaker, less active, and have lower performance in measures of physical fitness than their normal weight peers. Thin children are also more frequently subjected to teasing and stigmatization. Little is known about thin children's weight perceptions, desired weight and attitudes and behaviours towards food and exercise. The study aimed to compare perceived weight status, desired weight, eating and exercise behaviours and advice received from parents among thin, overweight, obese or normal weight Australian children and adolescents. The sample included 8550 school children aged 6 to 18 years selected from every state and territory of Australia. The children were weighed, measured and classified as thin, normal, overweight or obese using international standards. The main outcome measures were perceived and desired weight, weight related eating and exercising behaviours, and advice received from parents. The distribution of weight status was - thin 4.4%; normal weight 70.7%; overweight 18.3%; and obese 6.6%. Thin children were significantly shorter than normal weight, overweight or obese children and they were also more likely to report regularly consuming meals and snacks. 57.4% of thin children, 83.1% of normal weight children, 63.7% of overweight and 38.3% of obese children perceived their weight as "about right". Of the thin children, 53.9% wanted to be heavier, 36.2% wanted to stay the same weight, and 9.8% wanted to weigh less. Thin children were significantly less likely than obese children to respond positively to statements such as "I am trying to get fitter" or "I need to get more exercise." Parents were significantly less likely to recommend exercise for thin children compared with other weight groups. Thin children, as well as those who are overweight or obese, are less likely than normal weight children to consider their weight "about right'. Thin children differ from children of other weights in that thin children are less

  13. Perceived and desired weight, weight related eating and exercising behaviours, and advice received from parents among thin, overweight, obese or normal weight Australian children and adolescents

    Directory of Open Access Journals (Sweden)

    Amy Nancy K

    2011-06-01

    Full Text Available Abstract Background Thin children are less muscular, weaker, less active, and have lower performance in measures of physical fitness than their normal weight peers. Thin children are also more frequently subjected to teasing and stigmatization. Little is known about thin children's weight perceptions, desired weight and attitudes and behaviours towards food and exercise. The study aimed to compare perceived weight status, desired weight, eating and exercise behaviours and advice received from parents among thin, overweight, obese or normal weight Australian children and adolescents. Methods The sample included 8550 school children aged 6 to 18 years selected from every state and territory of Australia. The children were weighed, measured and classified as thin, normal, overweight or obese using international standards. The main outcome measures were perceived and desired weight, weight related eating and exercising behaviours, and advice received from parents. Results The distribution of weight status was - thin 4.4%; normal weight 70.7%; overweight 18.3%; and obese 6.6%. Thin children were significantly shorter than normal weight, overweight or obese children and they were also more likely to report regularly consuming meals and snacks. 57.4% of thin children, 83.1% of normal weight children, 63.7% of overweight and 38.3% of obese children perceived their weight as "about right". Of the thin children, 53.9% wanted to be heavier, 36.2% wanted to stay the same weight, and 9.8% wanted to weigh less. Thin children were significantly less likely than obese children to respond positively to statements such as "I am trying to get fitter" or "I need to get more exercise." Parents were significantly less likely to recommend exercise for thin children compared with other weight groups. Conclusions Thin children, as well as those who are overweight or obese, are less likely than normal weight children to consider their weight "about right'. Thin children

  14. On Double Vector Bundles

    Institute of Scientific and Technical Information of China (English)

    Zhuo CHEN; Zhang Ju LIU; Yun He SHENG

    2014-01-01

    In this paper, we construct a category of short exact sequences of vector bundles and prove that it is equivalent to the category of double vector bundles. Moreover, operations on double vector bundles can be transferred to operations on the corresponding short exact sequences. In particular, we study the duality theory of double vector bundles in term of the corresponding short exact sequences. Examples including the jet bundle and the Atiyah algebroid are discussed.

  15. On Double Vector Bundles

    OpenAIRE

    Chen, Zhuo; Liu, Zhangju; Sheng, Yunhe

    2011-01-01

    In this paper, we construct a category of short exact sequences of vector bundles and prove that it is equivalent to the category of double vector bundles. Moreover, operations on double vector bundles can be transferred to operations on the corresponding short exact sequences. In particular, we study the duality theory of double vector bundles in term of the corresponding short exact sequences. Examples including the jet bundle and the Atiyah algebroid are discussed.

  16. Prevalence of neutralizing antibodies against liver-tropic adeno-associated virus serotype vectors in 100 healthy Chinese and its potential relation to body constitutions

    Institute of Scientific and Technical Information of China (English)

    Chen Ling; Irene Zolotukhin; Arun Srivastava; Chang-quan Ling; Yuan Wang; Ying-lu Feng; Ya-ni Zhang; Jun Li; Xin-rui Hu; Li-na Wang; Mao-feng Zhong; Xiao-feng Zhai

    2015-01-01

    Recombinant adeno-associated virus (rAAV) serotype 2, 3 and 8 vectors are the most promising liver-tropic AAV serotype vectors. Liver diseases are signiifcant problems in China. However, to date, few studies on AAV neutralizing antibodies (Nabs) were working with the Chinese population or with the rAAV3 vectors. The present study aimed to determine the prevalence of Nabs in Chinese population against wild-type AAV2, AAV3 and AAV8 capsids as wel as additional two AAV3 variants. In addition, we performed a preliminary analysis to investigate the potential inlfuence of traditional Chinese medicine body constitutions on AAV Nabs. Our work demonstrated that the majority of healthy Chinese subjects were positive for AAV Nabs, with the order of AAV2 > AAV3 = AAVLK03 > AAV8. There was no difference between: 1) AAV3 and its variants; 2) male and female subjects; and 3) different age cohorts (≤ 35, 36–50, and ≥ 51 years old). People in the Qi-deifciency constitution had signiifcantly increased AAV8 Nabs than people in the Gentleness constitution. Our studies may have impact on the future clinical design of AAV-based gene therapy in the Chinese population.

  17. The Potential for Dispersal of Onchocerciasis in Ecuador in Relation to the Distribution of the Vector Simulium exiguum (Diptera:Simuliidae

    Directory of Open Access Journals (Sweden)

    Charalambous M

    1997-01-01

    Full Text Available The future dispersal of onchocerciasis in Ecuador is dependent on the distribution of cytotypes of the vector species complex Simulium exiguum. Over the last 14 years, collections of larvae have been made from over 25 rivers, between 80-1600 m altitude, from various sites on both sides of the Andes. Analysis of larval polytene chromosomes was used to determine the distributions of each cytotype. On the western side of the Andes, the Cayapa cytotype (the only cytotype directly incriminated as a vector has a distribution from Santo Domingo de los Colorados northwards. The Quevedo and Bucay cytotypes occur from Santo Domingo de los Colorados southwards. On the eastern side of the Andes, the Aguarico cytotype occurs in the Rio Aguarico and a new cytotype is present in the tributaries of the Rio Napo. Whether the disease will spread south of Santo Domingo and on the eastern side of the Andes depends on vector capacity of the cytotypes and the dispersal patterns of individuals infected with onchocerciasis. At present the Aguarico, Bucay and Quevedo cytotypes are known to be efficient hosts, but their biting preferences and biting densities have not yet been evaluated

  18. Custodial vector model

    DEFF Research Database (Denmark)

    Becciolini, Diego; Franzosi, Diogo Buarque; Foadi, Roshan;

    2015-01-01

    We analyze the Large Hadron Collider (LHC) phenomenology of heavy vector resonances with a $SU(2)_L\\times SU(2)_R$ spectral global symmetry. This symmetry partially protects the electroweak S-parameter from large contributions of the vector resonances. The resulting custodial vector model spectrum...

  19. Custodial vector model

    DEFF Research Database (Denmark)

    Becciolini, Diego; Franzosi, Diogo Buarque; Foadi, Roshan

    2015-01-01

    We analyze the Large Hadron Collider (LHC) phenomenology of heavy vector resonances with a $SU(2)_L\\times SU(2)_R$ spectral global symmetry. This symmetry partially protects the electroweak S-parameter from large contributions of the vector resonances. The resulting custodial vector model spectrum...

  20. Systematic review with meta-analysis: Dietary adherence influences normalization of health-related quality of life in coeliac disease.

    Science.gov (United States)

    Burger, Jordy P W; de Brouwer, Bart; IntHout, Joanna; Wahab, Peter J; Tummers, Marcia; Drenth, Joost P H

    2017-04-01

    Gluten-free diet is the keystone of coeliac disease treatment. Despite adherence, some patients continue to suffer from symptoms that negatively influence health-related quality of life (HRQoL). Therefore we performed a systematic review and meta-analysis to assess the effect of gluten-free diet on HRQoL in coeliac disease. We specifically sought for determinants that negatively influenced HRQoL. We systematically searched PubMed, EMBASE, CINAHL, PsycINFO and Cochrane Library for studies assessing HRQoL in untreated or treated adults using validated HRQoL-questionnaires from 1960 to September 2015, comparing HRQoL: (1) before and after gluten-free diet initiation or (2) in patients and non-coeliac controls. We included eighteen studies and sixteen were suitable for meta-analysis. Gluten-free diet significantly improves HRQoL, for psychological general well-being (PGWB)-Total (mean difference (MD) 7.34, 95% confidence interval (CI) [1.96; 12.72]; p = 0.008), SF-36 Mental Component Score (MCS) (MD 7.37, 95% CI [1.84; 12.90]; p = 0.009) and SF-36 Physical Component Score (PCS) (MD 5.72, 95% CI [1.50; 9.95]; p = 0.008). Treated patients had similar HRQoL compared with controls for PGWB-Total (MD -0.72, 95% CI [-2.71; 1.27]; p = 0.48), but significantly lower levels for SF-36 MCS (MD -4.09, 95% CI [-6.17; -2.01]; p = 0.0001) and PCS (MD -4.57, 95% CI [-6.97; -2.17]; p = 0.0002). Symptom-detected gluten-free diet adhering patients have lower HRQoL compared with screening-detected patients (MD -3.73, 95% CI [-6.77;-0.69]; p = 0.02) Strict adhering patients have better HRQoL compared with non-strict adhering patients for SF-36 MCS (MD 7.70, 95% CI [4.61; 10.79]; p coeliac disease. Dietary adherence improves HRQoL. Better (self-reported) dietary adherence results in higher HRQoL. Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  1. Breath acetone-aspects of normal physiology related to age and gender as determined in a PTR-MS study.

    Science.gov (United States)

    Schwarz, K; Pizzini, A; Arendacká, B; Zerlauth, K; Filipiak, W; Schmid, A; Dzien, A; Neuner, S; Lechleitner, M; Scholl-Bürgi, S; Miekisch, W; Schubert, J; Unterkofler, K; Witkovský, V; Gastl, G; Amann, A

    2009-06-01

    The present study was performed to determine the variations of breath acetone concentrations with age, gender and body-mass index (BMI). Previous investigations were based on a relatively small cohort of subjects (see Turner et al 2006 Physiol. Meas. 27 321-37). Since exhaled breath analysis is affected by considerable variation, larger studies are needed to get reliable information about the correlation of concentrations of volatiles in breath when compared with age, gender and BMI. Mixed expiratory exhaled breath was sampled using Tedlar bags. The concentrations of a mass-to-charge ratio (m/z) of 59, attributed to acetone, were then determined using proton transfer reaction-mass spectrometry. Our cohort, consisting of 243 adult volunteers not suffering from diabetes, was divided into two groups: one that fasted overnight prior to sampling (215 volunteers) and the other without a dietary control (28 volunteers). In addition, we considered a group of 44 healthy children (5-11 years old).The fasted subjects' concentrations of acetone ranged from 177 ppb to 2441 ppb, with an overall geometric mean (GM) of 628 ppb; in the group without a dietary control, the subjects' concentrations ranged from 281 ppb to 1246 ppb with an overall GM of 544 ppb. We found no statistically significant shift between the distributions of acetone levels in the breath of males and females in the fasted group (the Wilcoxon-Mann-Whitney test yielded p = 0.0923, the medians being 652 ppb and 587 ppb). Similarly, there did not seem to be a difference between the acetone levels of males and females in the group without a dietary control. Aging was associated with a slight increase of acetone in the fasted females; in males the increase was not statistically significant. Compared with the adults (a merged group), our group of children (5-11 years old) showed lower concentrations of acetone (p ppb. No correlation was found between the acetone levels and BMI in adults. Our results extend those of

  2. Coexisting bicuspid aortic and pulmonary valves with normally related great vessels diagnosed by live/real time three-dimensional transesophageal echocardiography.

    Science.gov (United States)

    Kemaloğlu Öz, Tuğba; Karadeniz, Fatma Özpamuk; Gundlapalli, Hareesh; Erer, Betul; Sharma, Rohit K; Ahmed, Mustafa; Nanda, Navin C; Yıldırım, Aydın; Orhan, Gökçen; Öz, Ayhan; Eren, Mehmet

    2014-02-01

    Coexistence of bicuspid aortic and pulmonary valves in the same patient is a very rare entity identified mainly during surgery and postmortem. To the best of our knowledge, only one case has been diagnosed by two-dimensional echocardiography in a newborn with malposition of the great arteries but no images were presented. Here, we are reporting the first case of bicuspid pulmonary and aortic valves diagnosed by live/real time three-dimensional transesophageal echocardiography in an adult with normally related great arteries. © 2014, Wiley Periodicals, Inc.

  3. Sparse Matrix Vector Processing Formats

    NARCIS (Netherlands)

    Stathis, P.T.

    2004-01-01

    In this dissertation we have identified vector processing shortcomings related to the efficient storing and processing of sparse matrices. To alleviate existent problems we propose two storage formats denoted as Block Based Compression Storage (BBCS) format and Hierarchical Sparse Matrix (HiSM) stor

  4. Vector Bundles over Elliptic Fibrations

    CERN Document Server

    Friedman, R; Witten, Edward; Friedman, Robert; Morgan, John W.; Witten, Edward

    1997-01-01

    This paper gives various methods for constructing vector bundles over elliptic curves and more generally over families of elliptic curves. We construct universal families over generalized elliptic curves via spectral cover methods and also by extensions, and then give a relative version of the construction in families. We give various examples and make Chern class computations.

  5. Differential expression of Nogo-B in preeclampsia placental tissue and normal placental tissue and its correlation with illness-related molecule expression

    Institute of Scientific and Technical Information of China (English)

    Fu-Rong Xu; Hai-Yan Wang

    2016-01-01

    Objective:To study the differential expression of Nogo-B in preeclampsia placental tissue and normal placental tissue and its correlation with illness-related molecule expression.Methods:Placental tissue of preeclampsia puerperas and normal pregnancy puerperas was collected, PCR method was used to detect mRNA contents of Nogo-B and apoptosis genes (Fas, Caspase-3 and Caspase-9) and Elisa was used to detect protein contents of inflammatory factors (TNF-α, IL-1β, IL-6, IL-8, CD40L and VCAM-1) and endothelial injury molecules (LOX-1, ox-LDL, PTX3 and ADM).Results:mRNA content of Nogo-B in preeclampsia placental tissue was significantly higher than that in normal placental tissue and the more severe the disease, the higher the mRNA content of Nogo-B; mRNA contents of Fas, Caspase-3 and Caspase-9 as well as protein contents of TNF-α, IL-1β, IL-6, IL-8, CD40L, VCAM-1, LOX-1, ox-LDL, PTX3 and ADM in preeclampsia placental tissue were significantly higher than those in normal placental tissue; mRNA content of Nogo-B was positively correlated with mRNA contents of Fas, Caspase-3 and Caspase-9 as well as protein contents of TNF-α, IL-1β, IL-6, IL-8, CD40L, VCAM-1, LOX-1, ox-LDL, PTX3 and ADM.Conclusions:Nogo-B expression in preeclampsia placental tissue significantly increases, and the molecule can regulate the generation of apoptosis genes, inflammatory factors and endothelial injury molecules to be involved in the occurrence of preeclampsia.

  6. Evaluation of regional left ventricular longitudinal function in 151 normal fetuses using velocity vector imaging%速度向量成像技术检测胎儿心肌节段功能的临床研究

    Institute of Scientific and Technical Information of China (English)

    彭清海; 周启昌; 曾施; 田蕾琪; 章鸣; 谭宜

    2008-01-01

    Objective To investigate the clinical value of VVI assessment normal fetal segmental myocardial performance and to establish a nomogram of normal fetus.Methods Digital dynamic fourchamber imaging of 151 healthy fetus(divided 5 groups according to gestation)were collected,then the longitudinal velocity,strain and strain rate of interventricular septal and left lateral wall were measured in systolic and diastolic period respectively.Results Normal systolic and diastolic values for tissue velocitv.strain,and strain rate were established.Tissue velocity was age dependent,whereas strain and strain rate were stable throughout gestation(P>0.05).Tissue velocity was gradually decreased from the base segment to the apical segment(P<0.01),whereas strain and strain rate were stable among all segments in every group(P>0.05).Conclusions Fetal myocardial velocity,strain,and strain rate measuraments are easy to obtain and reproducible,VVI is a novel noninvasive tool to assess quantitatively and objectivelv regional systolic and diastolic function in fetal heart,it is providing another useful modality for evaluating cardiac function.%目的 探讨速度向量成像技术检测正常胎儿左室心肌节段功能的临床应用价值.方法 应用Sequoia 512彩色多普勒超声诊断系统,在四腔心观采集151例孕18~40周的正常胎儿超声图像,用心肌速度向量软件分析左室后间隔和侧壁心肌长轴方向收缩期和舒张期峰值速度、应变及应变率.结果 各组基底段至心尖段心肌速度逐渐减低(P<0.01),各节段心肌应变和应变率差异无统计学意义(P>0.05).收缩期和舒张期峰值速度随孕周的增加而增大(P<0.01),而应变、应变率随孕周增加差异无统计学意义(P>0.05).结论 速度向量成像技术不受声束角度、胎方位、胎心率的影响,能够无创客观地定量评价胎儿左室长轴心肌节段舒缩功能,为临床检测胎儿心脏节段功能提供了又一有效方法 .

  7. Mining the bitter melon (momordica charantia l.) seed transcriptome by 454 analysis of non-normalized and normalized cDNA populations for conjugated fatty acid metabolism-related genes

    Science.gov (United States)

    Seeds of Momordica charantia (bitter melon) produce high levels of eleostearic acid, an unusual conjugated fatty acid with industrial value. Deep sequencing of non-normalized and normalized cDNAs from developing bitter melon seeds was conducted to uncover key genes required for biotechnological tran...

  8. A Note on Polarization Vectors in Quantum Electrodynamics

    Science.gov (United States)

    Lieb, Elliott H.; Loss, Michael

    2004-12-01

    A photon of momentum k can have only two polarization states, not three. Equivalently, one can say that the magnetic vector potential A must be divergence-free in the Coulomb gauge. These facts are normally taken into account in QED by introducing two polarization vectors ɛλ(k) with λ ∈ {1,2}, which are orthogonal to the wave-vector k. These vectors must be very discontinuous functions of k and, consequently, their Fourier transforms have bad decay properties. Since these vectors have no physical significance there must be a way to eliminate them and their bad decay properties from the theory. We propose such a way here.

  9. Medium Modification of Vector Mesons

    Energy Technology Data Exchange (ETDEWEB)

    Chaden Djalali, Michael Paolone, Dennis Weygand, Michael H. Wood, Rakhsha Nasseripour

    2011-03-01

    The theory of the strong interaction, Quantum Chromodynamics (QCD), has been remarkably successful in describing high-energy and short-distance-scale experiments involving quarks and gluons. However, applying QCD to low energy and large-distance scale experiments has been a major challenge. Various QCD-inspired models predict a partial restoration of chiral symmetry in nuclear matter with modifications of the properties of hadrons from their free-space values. Measurable changes such as a shift in mass and/or a change of width are predicted at normal nuclear density. Photoproduction of vector mesons off nuclei have been performed at different laboratories. The properties of the ρ, ω and φ mesons are investigated either directly by measuring their mass spectra or indirectly through transparency ratios. The latest results regarding medium modifications of the vector mesons in the nuclear medium will be discussed.

  10. The effect of voice quality and competing speakers in a passage comprehension task: perceived effort in relation to cognitive functioning and performance in children with normal hearing.

    Science.gov (United States)

    von Lochow, Heike; Lyberg-Åhlander, Viveka; Sahlén, Birgitta; Kastberg, Tobias; Brännström, K Jonas

    2017-04-03

    The study investigates the effect of voice quality and competing speakers on perceived effort in a passage comprehension task in relation to cognitive functioning. In addition, it explores if perceived effort was related to performance. A total of 49 children (aged 7:03 to 12:02 years) with normal hearing participated. The children performed an auditory passage comprehension task presented with six different listening conditions consisting of a typical voice or a dysphonic voice presented in quiet, with one competing speaker, and with four competing speakers. After completing the task, they rated their perceived effort on a five-grade scale. The children also performed tasks measuring working memory capacity (WMC) and executive functioning. The results show that voice quality had no direct effect on perceived effort but the children's ratings of perceived effort were related to their executive functioning. A significant effect was seen for background listening condition indicating higher perceived effort for background listening conditions with competing speakers. The effects of background listening condition were mainly related to the children's WMC but also their executive functioning. It can be concluded that the individual susceptibility to the effect of the dysphonic voice is related to the child's executive functioning. The individual susceptibility to the presence of competing speakers is related to the child's WMC and executive functioning.

  11. Nonlinear dynamics of a vectored thrust aircraft

    DEFF Research Database (Denmark)

    Sørensen, C.B; Mosekilde, Erik

    1996-01-01

    With realistic relations for the aerodynamic coefficients, numerical simulations are applied to study the longitudional dynamics of a thrust vectored aircraft. As function of the thrust magnitude and the thrust vectoring angle the equilibrium state exhibits two saddle-node bifurcations and three...

  12. Nonlinear dynamics of a vectored thrust aircraft

    DEFF Research Database (Denmark)

    Sørensen, C.B; Mosekilde, Erik

    1996-01-01

    With realistic relations for the aerodynamic coefficients, numerical simulations are applied to study the longitudional dynamics of a thrust vectored aircraft. As function of the thrust magnitude and the thrust vectoring angle the equilibrium state exhibits two saddle-node bifurcations and three ...

  13. Normalization mapping from redundant XML schema to relational schema%冗余XML模式到关系模式的规范化映射

    Institute of Scientific and Technical Information of China (English)

    洪欣; 陈苗; 蹇崇军

    2011-01-01

    从XML(extensible markup language)模式的语法分析冗余元素产生的原因,通过属性冗余的规范化规则消除属性冗余,元素冗余规范化算法消除元素冗余,嵌套冗余规范化算法消除嵌套冗余,从而实现XML模式到关系模式的关系映射.该算法不仅实现了一般关系的映射,而且实现了冗余XML模式到关系模式的规范化映射,具有不可逆性.%This article analyzes the XML (extensible markup language) schema grammar to find the root cause of the redundancy, eliminates the attribute redundancy, element redundancy and nesting redundancy by the attribute redundancy elimination rule, the element redundancy elimination rule and the nesting redundancy elimination rule respectively, realizes the relation mapping from XML schema to relational schema by the relation mapping rule. The algorithm not only realizes the normal mapping from XML schema to relational schema, but also realizes the mapping from the redundant XML to the relational schema. The mapping is non-reversible.

  14. Extracting long basic sequences from systems of dispersed vectors

    CERN Document Server

    Talponen, Jarno

    2010-01-01

    We study Banach spaces satisfying some geometric or structural properties involving tightness of transfinite sequences of nested linear subspaces. These properties are much weaker than WCG and closely related to Corson's property (C). Given a transfinite sequence of normalized vectors, which is dispersed or null in some sense, we extract a subsequence which is a biorthogonal sequence, or even a weakly null monotone basic sequence, depending on the setting. The Separable Complementation Property is established for spaces with an M-basis under rather weak geometric properties. We also consider an analogy of the Baire Category Theorem for the lattice of closed linear subspaces.

  15. Geoacoustic inversion using the vector field

    Science.gov (United States)

    Crocker, Steven E.

    The main goal of this project was to study the use of the acoustic vector field, separately or in combination with the scalar field, to estimate the depth dependent geoacoustic properties of the seafloor via non-linear inversion. The study was performed in the context of the Sediment Acoustics Experiment 2004 (SAX04) conducted in the Northern Gulf of Mexico (GOM) where a small number of acoustic vector sensors were deployed in close proximity to the seafloor. A variety of acoustic waveforms were transmitted into the seafloor at normal incidence. The acoustic vector sensors were located both above and beneath the seafloor interface where they measured the acoustic pressure and the acoustic particle acceleration. Motion data provided by the buried vector sensors were affected by a suspension response that was sensitive to the mass properties of the sensor, the sediment density and sediment elasticity (e.g., shear wave speed). The suspension response for the buried vector sensors included a resonance within the analysis band of 0.4 to 2.0 kHz. The suspension resonance represented an unknown complex transfer function between the acoustic vector field in the seabed and data representing that field. Therefore, inverse methods developed for this study were required to 1) estimate dynamic properties of the sensor suspension resonance and 2) account for the associated corruption of vector field data. A method to account for the vector sensor suspense response function was integrated directly into the inversion methods such that vector channel data corruption was reduced and an estimate of the shear wave speed in the sediment was returned. Inversions of real and synthetic data sets indicated that information about sediment shear wave speed was carried by the suspension response of the buried sensors, as opposed to being contained inherently within the acoustic vector field.

  16. Are Bred Vectors The Same As Lyapunov Vectors?

    Science.gov (United States)

    Kalnay, E.; Corazza, M.; Cai, M.

    Regional loss of predictability is an indication of the instability of the underlying flow, where small errors in the initial conditions (or imperfections in the model) grow to large amplitudes in finite times. The stability properties of evolving flows have been studied using Lyapunov vectors (e.g., Alligood et al, 1996, Ott, 1993, Kalnay, 2002), singular vectors (e.g., Lorenz, 1965, Farrell, 1988, Molteni and Palmer, 1993), and, more recently, with bred vectors (e.g., Szunyogh et al, 1997, Cai et al, 2001). Bred vectors (BVs) are, by construction, closely related to Lyapunov vectors (LVs). In fact, after an infinitely long breeding time, and with the use of infinitesimal ampli- tudes, bred vectors are identical to leading Lyapunov vectors. In practical applications, however, bred vectors are different from Lyapunov vectors in two important ways: a) bred vectors are never globally orthogonalized and are intrinsically local in space and time, and b) they are finite-amplitude, finite-time vectors. These two differences are very significant in a dynamical system whose size is very large. For example, the at- mosphere is large enough to have "room" for several synoptic scale instabilities (e.g., storms) to develop independently in different regions (say, North America and Aus- tralia), and it is complex enough to have several different possible types of instabilities (such as barotropic, baroclinic, convective, and even Brownian motion). Bred vectors share some of their properties with leading LVs (Corazza et al, 2001a, 2001b, Toth and Kalnay, 1993, 1997, Cai et al, 2001). For example, 1) Bred vectors are independent of the norm used to define the size of the perturba- tion. Corazza et al. (2001) showed that bred vectors obtained using a potential enstro- phy norm were indistinguishable from bred vectors obtained using a streamfunction squared norm, in contrast with singular vectors. 2) Bred vectors are independent of the length of the rescaling period as long as the

  17. Vector Diffusion Maps and the Connection Laplacian

    CERN Document Server

    Singer, Amit

    2011-01-01

    We introduce {\\em vector diffusion maps} (VDM), a new mathematical framework for organizing and analyzing massive high dimensional data sets, images and shapes. VDM is a mathematical and algorithmic generalization of diffusion maps and other non-linear dimensionality reduction methods, such as LLE, ISOMAP and Laplacian eigenmaps. While existing methods are either directly or indirectly related to the heat kernel for functions over the data, VDM is based on the heat kernel for vector fields. VDM provides tools for organizing complex data sets, embedding them in a low dimensional space, and interpolating and regressing vector fields over the data. In particular, it equips the data with a metric, which we refer to as the {\\em vector diffusion distance}. In the manifold learning setup, where the data set is distributed on (or near) a low dimensional manifold $\\MM^d$ embedded in $\\RR^{p}$, we prove the relation between VDM and the connection-Laplacian operator for vector fields over the manifold.

  18. Health Related Behaviours in Normal Weight and Overweight Preschoolers of a Large Pan-European Sample: The ToyBox-Study.

    Directory of Open Access Journals (Sweden)

    Greet Cardon

    Full Text Available The aim of this study was to investigate the associations of health related behaviours (HRB with Body Mass Index (BMI in preschoolers, and to study the likelihood of being overweight/obese in relation to compliance with recommended HRB. The sample consisted of 3301 normal weight and overweight/obese preschoolers (mean age: 4.7 years; 52% boys, 85% normal weight from six European countries (Belgium, Bulgaria, Germany, Greece, Poland, Spain. Height and weight were measured, total daily step counts were registered during six days, and HRB were assessed with validated parental surveys in 2012. Multiple linear and logistic regression analyses were performed. Only few HRB were significantly associated with BMI. In boys, higher water intake and higher soft drink and higher fruit consumption were significantly associated with higher BMI. Boys drinking less water than recommended were less likely to be overweight/obese (OR = 0.60, while boys who consume soft drinks were more likely to be overweight/obese (OR = 1.52. In girls, higher water intake, higher vegetable consumption, and more TV time on weekend days were significantly associated with higher BMI. Girls eating less vegetables than recommended were less likely to be overweight/obese (OR = 0.62, and girls who engaged in quiet play for more than 90 minutes on weekend days were more likely to be overweight/obese (OR = 1.64. In general, the associations between HRB and BMI or being overweight/obese were limited and mainly related to dietary intake. Awareness campaigns for caregivers should stress that HRB of young children are important and independent of children's weight status.

  19. Health Related Behaviours in Normal Weight and Overweight Preschoolers of a Large Pan-European Sample: The ToyBox-Study

    Science.gov (United States)

    Cardon, Greet; De Bourdeaudhuij, Ilse; Iotova, Violeta; Latomme, Julie; Socha, Piotr; Koletzko, Berthold; Moreno, Luis; Manios, Yannis; Androutsos, Odysseas; De Craemer, Marieke

    2016-01-01

    The aim of this study was to investigate the associations of health related behaviours (HRB) with Body Mass Index (BMI) in preschoolers, and to study the likelihood of being overweight/obese in relation to compliance with recommended HRB. The sample consisted of 3301 normal weight and overweight/obese preschoolers (mean age: 4.7 years; 52% boys, 85% normal weight) from six European countries (Belgium, Bulgaria, Germany, Greece, Poland, Spain). Height and weight were measured, total daily step counts were registered during six days, and HRB were assessed with validated parental surveys in 2012. Multiple linear and logistic regression analyses were performed. Only few HRB were significantly associated with BMI. In boys, higher water intake and higher soft drink and higher fruit consumption were significantly associated with higher BMI. Boys drinking less water than recommended were less likely to be overweight/obese (OR = 0.60), while boys who consume soft drinks were more likely to be overweight/obese (OR = 1.52). In girls, higher water intake, higher vegetable consumption, and more TV time on weekend days were significantly associated with higher BMI. Girls eating less vegetables than recommended were less likely to be overweight/obese (OR = 0.62), and girls who engaged in quiet play for more than 90 minutes on weekend days were more likely to be overweight/obese (OR = 1.64). In general, the associations between HRB and BMI or being overweight/obese were limited and mainly related to dietary intake. Awareness campaigns for caregivers should stress that HRB of young children are important and independent of children’s weight status. PMID:26950063

  20. Vehicle Based Vector Sensor

    Science.gov (United States)

    2015-09-28

    300001 1 of 16 VEHICLE-BASED VECTOR SENSOR STATEMENT OF GOVERNMENT INTEREST [0001] The invention described herein may be manufactured and...unmanned underwater vehicle that can function as an acoustic vector sensor . (2) Description of the Prior Art [0004] It is known that a propagating...mechanics. An acoustic vector sensor measures the particle motion via an accelerometer and combines Attorney Docket No. 300001 2 of 16 the

  1. Implicit Real Vector Automata

    Directory of Open Access Journals (Sweden)

    Jean-François Degbomont

    2010-10-01

    Full Text Available This paper addresses the symbolic representation of non-convex real polyhedra, i.e., sets of real vectors satisfying arbitrary Boolean combinations of linear constraints. We develop an original data structure for representing such sets, based on an implicit and concise encoding of a known structure, the Real Vector Automaton. The resulting formalism provides a canonical representation of polyhedra, is closed under Boolean operators, and admits an efficient decision procedure for testing the membership of a vector.

  2. Selective attention to food-related stimuli in hunger: are attentional biases specific to emotional and psychopathological states, or are they also found in normal drive states?

    Science.gov (United States)

    Mogg, K; Bradley, B P; Hyare, H; Lee, S

    1998-02-01

    Previous work has indicated that anxiety disorders and eating disorders are associated with selective processing of stimuli relevant to patients' concerns (e.g. Mathews and MacLeod, 1994; Annual Review of Psychology, 45, 25-50; Channon et al., 1988; British Journal of Clinical Psychology, 27, 259-260). A dot probe task was used to investigate whether attentional biases are also a feature of a normal drive state. Specifically, we examined whether hunger is associated with biases in selective attention and in pre-attentive processes for food-relevant stimuli. Subjects with high levels of hunger showed a greater attentional bias for food-related words presented in a suprathreshold exposure condition (words shown for 500 msec), in comparison with those with low hunger. There was no evidence in the present study of a hunger-related bias in pre-attentive processes (i.e. when words were shown for 14 msec and masked). Results suggest that a non-emotional motivational state, such as hunger, is associated with a bias in certain aspects of information processing, such as selective attention, for stimuli that are relevant to the motivational state. Findings are discussed in relation to recent research into emotion-related cognitive biases.

  3. Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity relate to longitudinal cortical thinning in normal aging.

    Science.gov (United States)

    Walhovd, Kristine B; Storsve, Andreas B; Westlye, Lars T; Drevon, Christian A; Fjell, Anders M

    2014-05-01

    We hypothesized that higher levels of omega-3 fatty acids, vitamin D, and physical activity relate to cortical sparing, whereas higher levels of cholesterol, systolic blood pressure, and body mass index (BMI) relate to increased atrophy in the adult lifespan. Longitudinal measures of cortical thickness were derived from magnetic resonance imaging scans acquired (mean interval 3.6 years) from 203 healthy persons aged 23-87 years. At follow-up, measures of BMI, blood pressure, and physical activity were obtained. Blood levels of docosahexaenoic acid, eicosapentaenoic acid, vitamin D, and cholesterol were measured in a subsample (n = 92). Effects were tested in cortical surface-based analyses, with sex, age, follow-up interval, and the interactions between each included as covariates. Higher levels of docosahexaenoic acid, vitamin D, and physical activity related to cortical sparing. Higher cholesterol and BMI related to increased cortical thinning. Effects were independent, did not interact with age, and the cholesterol effect was restricted to males. Eicosapentaenoic acid and blood pressure showed no effects. The observed effects show promise for potential factors to reduce cortical atrophy in normal aging.

  4. Vectors and their applications

    CERN Document Server

    Pettofrezzo, Anthony J

    2005-01-01

    Geared toward undergraduate students, this text illustrates the use of vectors as a mathematical tool in plane synthetic geometry, plane and spherical trigonometry, and analytic geometry of two- and three-dimensional space. Its rigorous development includes a complete treatment of the algebra of vectors in the first two chapters.Among the text's outstanding features are numbered definitions and theorems in the development of vector algebra, which appear in italics for easy reference. Most of the theorems include proofs, and coordinate position vectors receive an in-depth treatment. Key concept

  5. Distribution and migration of aftershocks of the 2010 Mw 7.4 Ogasawara Islands intraplate normal-faulting earthquake related to a fracture zone in the Pacific plate

    Science.gov (United States)

    Obana, Koichiro; Takahashi, Tsutomu; No, Tetsuo; Kaiho, Yuka; Kodaira, Shuichi; Yamashita, Mikiya; Sato, Takeshi; Nakamura, Takeshi

    2014-04-01

    describe the aftershocks of a Mw 7.4 intraplate normal-faulting earthquake that occurred 150 km east Ogasawara (Bonin) Islands, Japan, on 21 December 2010. It occurred beneath the outer trench slope of the Izu-Ogasawara trench, where the Pacific plate subducts beneath the Philippine Sea plate. Aftershock observations using ocean bottom seismographs (OBSs) began soon after the earthquake and multichannel seismic reflection surveys were conducted across the aftershock area. Aftershocks were distributed in a NW-SE belt 140 km long, oblique to the N-S trench axis. They formed three subparallel lineations along a fracture zone in the Pacific plate. The OBS observations combined with data from stations on Chichi-jima and Haha-jima Islands revealed a migration of the aftershock activity. The first hour, which likely outlines the main shock rupture, was limited to an 80 km long area in the central part of the subsequent aftershock area. The first hour activity occurred mainly around, and appears to have been influenced by, nearby large seamounts and oceanic plateau, such as the Ogasawara Plateau and the Uyeda Ridge. Over the following days, the aftershocks expanded beyond or into these seamounts and plateau. The aftershock distribution and migration suggest that crustal heterogeneities related to a fracture zone and large seamounts and oceanic plateau in the incoming Pacific plate affected the rupture of the main shock. Such preexisting structures may influence intraplate normal-faulting earthquakes in other regions of plate flexure prior to subduction.

  6. Prevalence of chronic kidney disease and anemia in patients with coronary artery disease with normal serum creatinine undergoing percutaneous coronary interventions: relation to New York Heart Association class.

    Science.gov (United States)

    Malyszko, Jolanta; Bachorzewska-Gajewska, Hanna; Malyszko, Jacek; Levin-Iaina, Nomy; Iaina, Adrian; Dobrzycki, Slawomir

    2010-08-01

    Kidney disease and cardiovascular disease seem to be lethally synergistic and both are approaching the epidemic level. A reduced glomerular filtration rate is associated with increased mortality risk in patients with heart failure. Many patients with congestive heart failure are anemic. Anemia is very often associated with chronic kidney disease. To assess--in relation to New York Heart Association class--the prevalence of anemia and chronic kidney disease in patients with normal serum creatinine in a cohort of 526 consecutive patients with coronary artery disease undergoing percutaneous coronary interventions. GFR was estimated using the simplified MDRD formula, the Cockcroft-Gault formula, the Jeliffe and the novel CKD-EPI formula. According to the WHO definition the prevalence of anemia in our study was 21%. We observed a progressive decline in GFR and hemoglobin concentration together with a rise in NYHA class. Significant correlations were observed between eGFR and systolic blood pressure, diastolic blood pressure, age, NYHA class, complications of PCI, including bleeding, and major adverse cardiac events. The prevalence of anemia and chronic kidney disease is high in patients undergoing PCI despite normal serum creatinine, particularly in higher NYHA class. Lower eGFR and hemoglobin are associated with more complications, including bleeding after PCI and higher prevalence of major adverse cardiac events. In patients with risk factors for cardiovascular disease, GFR should be estimated since renal dysfunction and subsequent anemia are important risk factors for cardiovascular morbidity and mortality.

  7. Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona muricata Linn. in normal and immortalized human cell lines.

    Science.gov (United States)

    George, V Cijo; Kumar, D R Naveen; Rajkumar, V; Suresh, P K; Kumar, R Ashok

    2012-01-01

    Natural products have been the target for cancer therapy for several years but there is still a dearth of information on potent compounds that may protect normal cells and selectively destroy cancerous cells. The present study was aimed to evaluate the cytotoxic potential of n-butanolic leaf extract of Annona muricata L. on WRL-68 (normal human hepatic cells), MDA-MB-435S (human breast carcinoma cells) and HaCaT (human immortalized keratinocyte cells) lines by XTT assay. Prior to cytotoxicity testing, the extract was subjected to phytochemical screening for detecting the presence of compounds with therapeutic potential. Their relative antioxidant properties were evaluated using the reducing power and DPPH* radical scavenging assay. Since most of the observed chemo-preventive potential invariably correlated with the amount of total phenolics present in the extract, their levels were quantified and identified by HPLC analysis. Correlation studies indicated a strong and significant (PAnnona muricata. Isolation of the active metabolites from the extract is in prospect.

  8. Normalizers of Irreducible Subfactors

    CERN Document Server

    Smith, Roger R; Wiggins, Alan D

    2007-01-01

    We consider normalizers of an irreducible inclusion $N\\subseteq M$ of $\\mathrm{II}_1$ factors. In the infinite index setting an inclusion $uNu^*\\subseteq N$ can be strict, forcing us to also investigate the semigroup of one-sided normalizers. We relate these normalizers of $N$ in $M$ to projections in the basic construction and show that every trace one projection in the relative commutant $N'\\cap $ is of the form $u^*e_Nu$ for some unitary $u\\in M$ with $uNu^*\\subseteq N$. This enables us to identify the normalizers and the algebras they generate in several situations. In particular each normalizer of a tensor product of irreducible subfactors is a tensor product of normalizers modulo a unitary. We also examine normalizers of irreducible subfactors arising from subgroup--group inclusions $H\\subseteq G$. Here the normalizers are the normalizing group elements modulo a unitary from $L(H)$. We are also able to identify the finite trace $L(H)$-bimodules in $\\ell^2(G)$ as double cosets which are also finite union...

  9. Bill related to the struggle against proliferation of mass destruction weapons and their vectors; Projet de Loi relatif a la lutte contre la proliferation des armes de destruction massive et de leurs vecteurs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This bill indicates the modifications brought to different French laws and codes (penal code, defence code, custom code) and defines provisions and penalties within the frame of struggle against the proliferation of weapons of mass destruction (nuclear weapons, biological weapons and toxin-based weapons, chemical weapons), and against the proliferation of their vectors. These modifications, provisions and penalties also concern double-use products. The bill also defines the modifications brought to the French penal procedure code. It finally addresses offenses related to these proliferations which can be considered as an act of terrorism

  10. Physical activity opposes the age-related increase in skeletal muscle and plasma endothelin-1 levels and normalizes plasma endothelin-1 levels in individuals with essential hypertension

    DEFF Research Database (Denmark)

    Nyberg, Michael Permin; Mortensen, Stefan Peter; Hellsten, Ylva

    2013-01-01

    AIMS: Endothelin-1 has potent constrictor and proliferative activity in vascular smooth muscle, and essential hypertension and aging are associated with increased endothelin-1-mediated vasoconstrictor tone. The aim of this study was to investigate the effect of physical activity, hypertension...... performed lifelong physical activity had similar plasma and muscle endothelin-1 levels as the young controls and had higher ET(A) receptor levels. CONCLUSION: Our findings suggest that aerobic exercise training opposes the age-related increase in skeletal muscle and plasma endothelin-1 levels and normalizes...... plasma endothelin-1 levels in individuals with essential hypertension. This effect may explain some of the beneficial effects of training on the cardiovascular system in older and hypertensive subjects....

  11. Enantiomer Separation of α-Dimethyl Dicarboxylate Biphenyl and Related Biphenyl Compounds by Normal Phase HPLC on Polysaccharide Based Chiral Stationary Phases

    Institute of Scientific and Technical Information of China (English)

    LIU,Yue-Qi(刘月启); HAN,Xiao-Qian(韩小茜); Qi,Bang-Feng(齐邦峰); LIU,Chun-Hui(柳春辉); LI,Yong-Min(李永民); CHEN,Li-Ren(陈立仁)

    2002-01-01

    Cellulose tris(4-methylphenylcarbamate), amylose tris(3,5-dimethylpphenylcarbamate) and amylose tris (phenylcarbamate)were prepared by the method reported by Okamoto and were coated onto an aminopropylated mesoporous spherical silica gel. These final products were used as chiral stationary phases of high performance liquid chromatography for the eighteen structurally related biphenyl conmpounds. The resolution was made using normal-phase methodology with a mobile phase consisting of n-hexane-alcohol (ethanol, 1-propanol, 2-propanol or 1-butanol). The effects of various aliphatic alcohols in the mobile phase were studied. The structural features of the solutes that influence their k'were discussed. A dominant effect of trifluoroaetic acid on chiral separation of aacidicdic solutes was noted.

  12. Normal BGG solutions and polynomials

    CERN Document Server

    Cap, A; Hammerl, M

    2012-01-01

    First BGG operators are a large class of overdetermined linear differential operators intrinsically associated to a parabolic geometry on a manifold. The corresponding equations include those controlling infinitesimal automorphisms, higher symmetries, and many other widely studied PDE of geometric origin. The machinery of BGG sequences also singles out a subclass of solutions called normal solutions. These correspond to parallel tractor fields and hence to (certain) holonomy reductions of the canonical normal Cartan connection. Using the normal Cartan connection, we define a special class of local frames for any natural vector bundle associated to a parabolic geometry. We then prove that the coefficient functions of any normal solution of a first BGG operator with respect to such a frame are polynomials in the normal coordinates of the parabolic geometry. A bound on the degree of these polynomials in terms of representation theory data is derived. For geometries locally isomorphic to the homogeneous model of ...

  13. 日菲关系正常化中的美国因素%American Factor in the Normalization of Relations between Japan and Philippines

    Institute of Scientific and Technical Information of China (English)

    袁绍佳

    2014-01-01

    In a variety of factors of the normalization of relations between Japan and Philippines , American factors play a role that can not be ignored .With the formation of the cold war , the strategic position of Philippines with a special relationship with America and Japan under occupation of America has become increasingly promi -nent .America hopes the two countries establish diplomatic relations as soon as possible to stabilize the Asia Pacific defense system;the issue of war reparations provided an opportunity for the two countries and America actively car-ry out mediation , while encouraging Philippines , also putting pressure on Japan , to promote the normal relationship between the two countries .%在日菲关系正常化的多种因素中,美国因素起着不可忽视的作用。随着冷战格局的形成,美国占领之下的日本和与美国保持特殊关系的菲律宾的战略地位日益凸显,美国希望二者尽快建交以稳固亚太防卫体系;战争赔偿问题为日菲交涉提供契机,美国积极从中展开斡旋,在鼓励菲律宾的同时亦对日本施压,推动日菲关系实现正常化。

  14. Linearization of germs of hyperbolic vector fields

    NARCIS (Netherlands)

    Bonckaert, P; Naudot, [No Value; Yang, JZ

    2003-01-01

    We develop a normal form to express asymptotically a conjugacy between a germ of resonant vector field and its linear part. We show that such an asymptotic expression can be written in terms of functions of the Logarithmic Mourtada type. To cite this article: P Bonckaert et al., C. R. Acad. Sci. Par

  15. Structural integrity of the corpus callosum predicts long-term transfer of fluid intelligence-related training gains in normal aging.

    Science.gov (United States)

    Wolf, Dominik; Fischer, Florian Udo; Fesenbeckh, Johanna; Yakushev, Igor; Lelieveld, Irene Maria; Scheurich, Armin; Schermuly, Ingrid; Zschutschke, Lisa; Fellgiebel, Andreas

    2014-01-01

    Although cognitive training usually improves cognitive test performance, the capability to transfer these training gains into respective or functionally related cognitive domains varies significantly. Since most studies demonstrate rather limited transfer effects in older adults, aging might be an important factor in transfer capability differences. This study investigated the transfer capability of logical reasoning training gains to a measure of Fluid Intelligence (Gf) in relation to age, general intelligence, and brain structural integrity as measured by diffusion tensor imaging. In a group of 41 highly educated healthy elderly, 71% demonstrated successful transfer immediately after a 4-week training session (i.e. short-term transfer). In a subgroup of 22% of subjects transfer maintained over a 3-month follow-up period (i.e. long-term transfer). While short-term transfer was not related to structural integrity, long-term transfer was associated with increased structural integrity in corpus and genu of the corpus callosum. Since callosal structural integrity was also related to age (in the present and foregoing studies), previously observed associations between age and transfer might be moderated by the structural integrity. Surprisingly, age was not directly associated with transfer in this study which could be explained by the multi-dependency of the structural integrity (modulating factors beside age, e.g. genetics). In this highly educated sample, general intelligence was not related to transfer suggesting that high intelligence is not sufficient for transfer in normal aging. Further studies are needed to reveal the interaction of transfer, age, and structural integrity and delineate mechanisms of age-dependent transfer capabilities.

  16. 600-GHz Electronically Tunable Vector Measurement System

    Science.gov (United States)

    Dengler, Robert; Maiwald, Frank; Siegel, Peter

    2007-01-01

    A compact, high-dynamic-range, electronically tunable vector measurement system that operates in the frequency range from approximately 560 to approximately 635 GHz has been developed as a prototype of vector measurement systems that would be suitable for use in nearly-real-time active submillimeter-wave imaging. As used here, 'vector measurement system" signifies an instrumentation system that applies a radio-frequency (RF) excitation to an object of interest and measures the resulting amplitude and phase response, relative to either the applied excitatory signal or another reference signal related in a known way to applied excitatory signal.

  17. Advancing vector biology research

    NARCIS (Netherlands)

    Kohl, Alain; Pondeville, Emilie; Schnettler, Esther; Crisanti, Andrea; Supparo, Clelia; Christophides, George K.; Kersey, Paul J.; Maslen, Gareth L.; Takken, Willem; Koenraadt, Constantianus J.M.; Oliva, Clelia F.; Busquets, Núria; Abad, F.X.; Failloux, Anna Bella; Levashina, Elena A.; Wilson, Anthony J.; Veronesi, Eva; Pichard, Maëlle; Arnaud Marsh, Sarah; Simard, Frédéric; Vernick, Kenneth D.

    2016-01-01

    Vector-borne pathogens impact public health, animal production, and animal welfare. Research on arthropod vectors such as mosquitoes, ticks, sandflies, and midges which transmit pathogens to humans and economically important animals is crucial for development of new control measures that target t

  18. Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    The two branches of dynamical systems, continuous and discrete, correspond to the study of differential equations (vector fields) and iteration of mappings respectively. In holomorphic dynamics, the systems studied are restricted to those described by holomorphic (complex analytic) functions...... vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...... of parameter spaces into structurally stable domains, and a description of the bifurcations. For this reason, the talk will focus on these questions for complex polynomial vector fields....

  19. Application of Genomics for Understanding Plant Virus-Insect Vector Interactions and Insect Vector Control.

    Science.gov (United States)

    Kaur, Navneet; Hasegawa, Daniel K; Ling, Kai-Shu; Wintermantel, William M

    2016-10-01

    The relationships between plant viruses and their vectors have evolved over the millennia, and yet, studies on viruses began virus and vector interactions even more recently. The advent of next generation sequencing, including rapid genome and transcriptome analysis, methods for evaluation of small RNAs, and the related disciplines of proteomics and metabolomics offer a significant shift in the ability to elucidate molecular mechanisms involved in virus infection and transmission by insect vectors. Genomic technologies offer an unprecedented opportunity to examine the response of insect vectors to the presence of ingested viruses through gene expression changes and altered biochemical pathways. This review focuses on the interactions between viruses and their whitefly or thrips vectors and on potential applications of genomics-driven control of the insect vectors. Recent studies have evaluated gene expression in vectors during feeding on plants infected with begomoviruses, criniviruses, and tospoviruses, which exhibit very different types of virus-vector interactions. These studies demonstrate the advantages of genomics and the potential complementary studies that rapidly advance our understanding of the biology of virus transmission by insect vectors and offer additional opportunities to design novel genetic strategies to manage insect vectors and the viruses they transmit.

  20. Mosquito vectors of dog heartworm in the United States: vector status and factors influencing transmission efficiency.

    Science.gov (United States)

    Ledesma, Nicholas; Harrington, Laura

    2011-11-01

    Dog heartworm (Dirofilaria immitis) is dependent on mosquito vectors for its maintenance and transmission among vertebrate hosts. Consequently, D. immitis abundance and distribution are closely linked with mosquito vector biology and ecology. Information on the important dog heartworm vectors in the United States is limited and no comprehensive surveillance of dog heartworm in US mosquitoes has been undertaken to date. Here, we review information gleaned from a number of field surveys documenting heartworm presence in wild mosquito populations as well as laboratory assessments of mosquito vector capacity. Various biological and ecological factors likely contribute to the relative importance of different vector species. We describe some of these factors, rank the leading criteria for efficient vectors, and present the most likely vector species found across the United States. Considering the recent emergence of drug resistance among D. immitis strains, practical knowledge of heartworm vector biology and control should be incorporated into heartworm disease management programs. We conclude by proposing that heartworm control would benefit by targeting mosquito vectors, and we suggest ways in which veterinarians can incorporate the recognition of vector importance into heartworm prevention recommendations imparted to clients. Copyright © 2011 Elsevier Inc. All rights reserved.

  1. Biosafety features of lentiviral vectors.

    Science.gov (United States)

    Schambach, Axel; Zychlinski, Daniela; Ehrnstroem, Birgitta; Baum, Christopher

    2013-02-01

    Over the past decades, lentiviral vectors have evolved as a benchmark tool for stable gene transfer into cells with a high replicative potential. Their relatively flexible genome and ability to transduce many forms of nondividing cells, combined with the potential for cell-specific pseudotyping, provides a rich resource for numerous applications in experimental platforms and therapeutic settings. Here, we give an overview of important biosafety features of lentiviral vectors, with detailed discussion of (i) the principles of the lentiviral split-genome design used for the construction of packaging cells; (ii) the relevance of modifications introduced into the lentiviral long terminal repeat (deletion of enhancer/promoter sequences and introduction of insulators); (iii) the basic features of mRNA processing, including the Rev/Rev-responsive element (RRE) interaction and the modifications of the 3' untranslated region of lentiviral vectors with various post-transcriptional regulatory elements affecting transcriptional termination, polyadenylation, and differentiation-specific degradation of mRNA; and (iv) the characteristic integration pattern with the associated risk of transcriptional interference with cellular genes. We conclude with considerations regarding the importance of cell targeting via envelope modifications. Along this course, we address canonical biosafety issues encountered with any type of viral vector: the risks of shedding, mobilization, germline transmission, immunogenicity, and insertional mutagenesis.

  2. Intragenic vectors for gene transfer without foreign DNA

    NARCIS (Netherlands)

    Conner, A.J.; Barrell, P.J.; Baldwin, S.J.; Lokerse, A.S.; Cooper, P.A.; Erasmuson, A.K.; Nap, J.P.H.; Jacobs, J.M.E.

    2007-01-01

    The intragenic vector system involves identifying functional equivalents of vector components from the genome of a specific crop species (or related species to which it can be hybridised) and using these DNA sequences to assemble vectors for transformation of that plant species. This system offers a

  3. Clifford Fourier transform on vector fields.

    Science.gov (United States)

    Ebling, Julia; Scheuermann, Gerik

    2005-01-01

    Image processing and computer vision have robust methods for feature extraction and the computation of derivatives of scalar fields. Furthermore, interpolation and the effects of applying a filter can be analyzed in detail and can be advantages when applying these methods to vector fields to obtain a solid theoretical basis for feature extraction. We recently introduced the Clifford convolution, which is an extension of the classical convolution on scalar fields and provides a unified notation for the convolution of scalar and vector fields. It has attractive geometric properties that allow pattern matching on vector fields. In image processing, the convolution and the Fourier transform operators are closely related by the convolution theorem and, in this paper, we extend the Fourier transform to include general elements of Clifford Algebra, called multivectors, including scalars and vectors. The resulting convolution and derivative theorems are extensions of those for convolution and the Fourier transform on scalar fields. The Clifford Fourier transform allows a frequency analysis of vector fields and the behavior of vector-valued filters. In frequency space, vectors are transformed into general multivectors of the Clifford Algebra. Many basic vector-valued patterns, such as source, sink, saddle points, and potential vortices, can be described by a few multivectors in frequency space.

  4. The Ups and Downs of the Posteromedial Cortex: Age- and Amyloid-Related Functional Alterations of the Encoding/Retrieval Flip in Cognitively Normal Older Adults

    Science.gov (United States)

    Vannini, Patrizia; Hedden, Trey; Huijbers, Willem; Ward, Andrew; Johnson, Keith A.; Sperling, Reisa A.

    2013-01-01

    Neural networks supporting memory function decline with increasing age. Accumulation of amyloid-β, a histopathological finding in Alzheimer's disease, is a likely contributor. Posteromedial cortices (PMCs) are particularly vulnerable to early amyloid pathology and play a role in both encoding and retrieval processes. The extent to which aging and amyloid influence the ability to modulate activity between these processes within the PMC was investigated by combining positron emission tomography-amyloid imaging with functional magnetic resonance imaging in cognitively normal older and young adults. Young subjects exhibited a marked decrease in activity during encoding and an increase during retrieval (also known as encoding/retrieval “flip”). Impaired ability to modulate activity was associated with increasing age, greater amyloid burden, and worse memory performance. In contrast, the hippocampus showed increased activity during both encoding and retrieval, which was not related to these variables. These findings support a specific link between amyloid pathology and neural dysfunction in PMC and elucidate the underpinnings of age-related memory dysfunction. PMID:22586140

  5. Normalized cDNA libraries

    Science.gov (United States)

    Soares, Marcelo B.; Efstratiadis, Argiris

    1997-01-01

    This invention provides a method to normalize a directional cDNA library constructed in a vector that allows propagation in single-stranded circle form comprising: (a) propagating the directional cDNA library in single-stranded circles; (b) generating fragments complementary to the 3' noncoding sequence of the single-stranded circles in the library to produce partial duplexes; (c) purifying the partial duplexes; (d) melting and reassociating the purified partial duplexes to moderate Cot; and (e) purifying the unassociated single-stranded circles, thereby generating a normalized cDNA library.

  6. Normality in analytical psychology.

    Science.gov (United States)

    Myers, Steve

    2013-12-01

    Although C.G. Jung's interest in normality wavered throughout his career, it was one of the areas he identified in later life as worthy of further research. He began his career using a definition of normality which would have been the target of Foucault's criticism, had Foucault chosen to review Jung's work. However, Jung then evolved his thinking to a standpoint that was more aligned to Foucault's own. Thereafter, the post Jungian concept of normality has remained relatively undeveloped by comparison with psychoanalysis and mainstream psychology. Jung's disjecta membra on the subject suggest that, in contemporary analytical psychology, too much focus is placed on the process of individuation to the neglect of applications that consider collective processes. Also, there is potential for useful research and development into the nature of conflict between individuals and societies, and how normal people typically develop in relation to the spectrum between individuation and collectivity.

  7. Vaxvec: The first web-based recombinant vaccine vector database and its data analysis.

    Science.gov (United States)

    Deng, Shunzhou; Martin, Carly; Patil, Rasika; Zhu, Felix; Zhao, Bin; Xiang, Zuoshuang; He, Yongqun

    2015-11-27

    A recombinant vector vaccine uses an attenuated virus, bacterium, or parasite as the carrier to express a heterologous antigen(s). Many recombinant vaccine vectors and related vaccines have been developed and extensively investigated. To compare and better understand recombinant vectors and vaccines, we have generated Vaxvec (http://www.violinet.org/vaxvec), the first web-based database that stores various recombinant vaccine vectors and those experimentally verified vaccines that use these vectors. Vaxvec has now included 59 vaccine vectors that have been used in 196 recombinant vector vaccines against 66 pathogens and cancers. These vectors are classified to 41 viral vectors, 15 bacterial vectors, 1 parasitic vector, and 1 fungal vector. The most commonly used viral vaccine vectors are double-stranded DNA viruses, including herpesviruses, adenoviruses, and poxviruses. For example, Vaxvec includes 63 poxvirus-based recombinant vaccines for over 20 pathogens and cancers. Vaxvec collects 30 recombinant vector influenza vaccines that use 17 recombinant vectors and were experimentally tested in 7 animal models. In addition, over 60 protective antigens used in recombinant vector vaccines are annotated and analyzed. User-friendly web-interfaces are available for querying various data in Vaxvec. To support data exchange, the information of vaccine vectors, vaccines, and related information is stored in the Vaccine Ontology (VO). Vaxvec is a timely and vital source of vaccine vector database and facilitates efficient vaccine vector research and development.

  8. Nonlinear singular vectors and nonlinear singular values

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A novel concept of nonlinear singular vector and nonlinear singular value is introduced, which is a natural generalization of the classical linear singular vector and linear singular value to the nonlinear category. The optimization problem related to the determination of nonlinear singular vectors and singular values is formulated. The general idea of this approach is demonstrated by a simple two-dimensional quasigeostrophic model in the atmospheric and oceanic sciences. The advantage and its applications of the new method to the predictability, ensemble forecast and finite-time nonlinear instability are discussed. This paper makes a necessary preparation for further theoretical and numerical investigations.

  9. A comparison of foamy and lentiviral vector genotoxicity in SCID-repopulating cells shows foamy vectors are less prone to clonal dominance

    Directory of Open Access Journals (Sweden)

    Elizabeth M Everson

    2016-01-01

    Full Text Available Hematopoietic stem cell (HSC gene therapy using retroviral vectors has immense potential, but vector-mediated genotoxicity limits use in the clinic. Lentiviral vectors are less genotoxic than gammaretroviral vectors and have become the vector of choice in clinical trials. Foamy retroviral vectors have a promising integration profile and are less prone to read-through transcription than gammaretroviral or lentiviral vectors. Here, we directly compared the safety and efficacy of foamy vectors to lentiviral vectors in human CD34+ repopulating cells in immunodeficient mice. To increase their genotoxic potential, foamy and lentiviral vectors with identical transgene cassettes with a known genotoxic spleen focus forming virus promoter were used. Both vectors resulted in efficient marking in vivo and a total of 825 foamy and 460 lentiviral vector unique integration sites were recovered in repopulating cells 19 weeks after transplantation. Foamy vector proviruses were observed less often near RefSeq gene and proto-oncogene transcription start sites than lentiviral vectors. The foamy vector group were also more polyclonal with fewer dominant clones (two out of six mice than the lentiviral vector group (eight out of eight mice, and only lentiviral vectors had integrants near known proto-oncogenes in dominant clones. Our data further support the relative safety of foamy vectors for HSC gene therapy.

  10. Scientific Opinion on the substantiation of health claims related to glycaemic carbohydrates and maintenance of normal brain function pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    an opinion on the scientific substantiation of health claims related to glycaemic carbohydrates and maintenance of normal brain function. The scope of the applications was proposed to fall under health claims based on newly developed scientific evidence. The Panel considers that the food constituent......, glycaemic carbohydrates, which is the subject of the health claims, is sufficiently characterised in relation to the claimed effect. Maintenance of normal brain function is a beneficial physiological effect. A claim on glycaemic carbohydrates and maintenance of normal brain function has already been...

  11. Light composite vector bosons

    CERN Document Server

    Kosower, David A.

    1993-01-01

    In gauge theories with slowly-running coupling constants, it may be possible for four-fermion operators to be nearly marginal. Such operators can possess asymptotically weak couplings, and can plausibly give rise to light composite vector mesons.

  12. GAP Land Cover - Vector

    Data.gov (United States)

    Minnesota Department of Natural Resources — This vector dataset is a detailed (1-acre minimum), hierarchically organized vegetation cover map produced by computer classification of combined two-season pairs of...

  13. Tagged Vector Contour (TVC)

    Data.gov (United States)

    Kansas Data Access and Support Center — The Kansas Tagged Vector Contour (TVC) dataset consists of digitized contours from the 7.5 minute topographic quadrangle maps. Coverage for the state is incomplete....

  14. Some study on the growth properties of entire functions represented by vector valued Dirichlet series in the light of relative Ritt orders

    Directory of Open Access Journals (Sweden)

    Sanjib Datta

    2016-02-01

    Full Text Available For entire functions, the notions of their growth indicators such as Ritt order are classical in complex analysis. But the concepts of relative Ritt order of entire functions and as well as their technical advantages of not comparing with the growths of $exp exp z$ are not at all known to the researchers of this area. Therefore the studies of the growths of entire functions in the light of their relative Ritt order are the prime concern of this paper. Actually in this paper we establish some newly developed results related to the growth rates of entire functions on the basis of their relative Ritt order (respectively, relative Ritt lower order.

  15. Preclinical potency and safety studies of an AAV2-mediated gene therapy vector for the treatment of MERTK associated retinitis pigmentosa.

    Science.gov (United States)

    Conlon, Thomas J; Deng, Wen-Tao; Erger, Kirsten; Cossette, Travis; Pang, Ji-jing; Ryals, Renee; Clément, Nathalie; Cleaver, Brian; McDoom, Issam; Boye, Shannon E; Peden, Marc C; Sherwood, Mark B; Abernathy, Corinne R; Alkuraya, Fowzan S; Boye, Sanford L; Hauswirth, William W

    2013-03-01

    Abstract Proof of concept for MERTK gene replacement therapy has been demonstrated using different viral vectors in the Royal College of Surgeon (RCS) rat, a well characterized model of recessive retinitis pigmentosa that contains a mutation in the Mertk gene. MERTK plays a key role in renewal of photoreceptor outer segments (OS) by phagocytosis of shed OS tips. Mutations in MERTK cause impaired phagocytic activity and accumulation of OS debris in the interphotoreceptor space that ultimately leads to photoreceptor cell death. In the present study, we conducted a series of preclinical potency and GLP-compliant safety evaluations of an adeno-associated virus type 2 (AAV2) vector expressing human MERTK cDNA driven by the retinal pigment epithelium-specific, VMD2 promoter. We demonstrate the potency of the vector in RCS rats by improved electroretinogram (ERG) responses in treated eyes compared with contralateral untreated controls. Toxicology and biodistribution studies were performed in Sprague-Dawley (SD) rats injected with two different doses of AAV vectors and buffer control. Delivery of vector in SD rats did not result in a change in ERG amplitudes of rod and cone responses relative to balanced salt solution control-injected eyes, indicating that administration of AAV vector did not adversely affect normal retinal function. In vivo fundoscopic analysis and postmortem retinal morphology of the vector-injected eyes were normal compared with controls. Evaluation of blood smears showed the lack of transformed cells in the treated eyes. All injected eyes and day 1 blood samples were positive for vector genomes, and all peripheral tissues were negative. Our results demonstrate the potency and safety of the AAV2-VMD2-hMERTK vector in animal models tested. A GMP vector has been manufactured and is presently in clinical trial.

  16. HRE-type genes are regulated by growth-related changes in internal oxygen concentrations during the normal development of potato (Solanum tuberosum) tubers.

    Science.gov (United States)

    Licausi, Francesco; Giorgi, Federico Manuel; Schmälzlin, Elmar; Usadel, Björn; Perata, Pierdomenico; van Dongen, Joost Thomas; Geigenberger, Peter

    2011-11-01

    The occurrence of hypoxic conditions in plants not only represents a stress condition but is also associated with the normal development and growth of many organs, leading to adaptive changes in metabolism and growth to prevent internal anoxia. Internal oxygen concentrations decrease inside growing potato tubers, due to their active metabolism and increased resistance to gas diffusion as tubers grow. In the present work, we identified three hypoxia-responsive ERF (StHRE) genes whose expression is regulated by the gradual decrease in oxygen tensions that occur when potato tubers grow larger. Increasing the external oxygen concentration counteracted the modification of StHRE expression during tuber growth, supporting the idea that the actual oxygen levels inside the organs, rather than development itself, are responsible for the regulation of StHRE genes. We identified several sugar metabolism-related genes co-regulated with StHRE genes during tuber development and possibly involved in starch accumulation. All together, our data suggest a possible role for low oxygen in the regulation of sugar metabolism in the potato tuber, similar to what happens in storage tissues during seed development.

  17. Interleukin-1-mediated effects of normal oral keratinocytes and head and neck squamous carcinoma cells on extracellular matrix related gene expression in fibroblasts.

    Science.gov (United States)

    Hakelius, Malin; Koskela, Anita; Reyhani, Vahid; Ivarsson, Mikael; Grenman, Reidar; Rubin, Kristofer; Gerdin, Bengt; Nowinski, Daniel

    2012-12-01

    The composition of tumor stroma and the activity of tumor associated fibroblasts are important for tumor growth. Interactions between carcinoma cells and fibroblasts regulate the turnover of extracellular matrix (ECM). Here, the in vitro effects of oral squamous cell carcinoma (SCC) cells (UT-SCC-30 and UT-SCC-87) on fibroblast expression of genes for ECM components and connective tissue growth factor (CTGF/CCN2), were compared to those of normal oral keratinocytes (NOK). Cocultures with fibroblasts in collagen gels and keratinocytes with the two cell types separated by a semi permeable membrane were used, and relative gene expression was measured with real-time PCR. All investigated genes were regulated by NOK and the SCCs. The downregulation of pro-collagens α1(I) and α1(III) was more pronounced in cocultures with NOK, while the expression of CCN2 and fibronectin was downregulated by both NOK and the SCCs to a similar extent. UT-SCC-87, but not UT-SCC-30, secreted significantly more IL-1α than NOK. A recombinant interleukin-1 receptor antagonist reversed many of the observed effects on fibroblast gene expression suggesting involvement of IL-1 in cocultures with NOK as well as with SCCs. The observed differential effects on fibroblast gene expression suggest that NOK are more antifibrotic compared to UT-SCC-30 and UT-SCC-87. These findings may contribute to a better understanding of the mechanisms behind ECM turnover in tumors. Copyright © 2012 Elsevier Ltd. All rights reserved.

  18. Age-related decrease in an early step of DNA-repair of normal human lymphocytes exposed to ultraviolet-irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Roth, M.; Emmons, L.R.; Haener, M.M.; Mueller, H.J.B.; Boyle, J.M.

    1989-01-01

    A monoclonal antibody-based immunoassay has been used to detect age-related changes in the rate of loss of photoproduct antigenicity from the DNA of peripheral blood lymphocytes irradiated with 10 J m-2 uv-C. Lymphocytes were obtained from 75 healthy volunteers whose ages ranged from 14 months to 82 years. The samples were divided by age decades into groups of 10 individuals, except the first decade which contained only 5 individuals. The mean loss of antigenicity +/- 1 standard deviation was determined for each group at 10, 30, and 60 min after irradiation. The data were analyzed by Mann-Whitney U test and by the Kruskal-Wallis test. After a recovery period of 10 min the loss of antigenicity was most rapid in group I (0-9 years), less rapid in group II (10-19 years), and least rapid in all other groups. The differences between groups became less at 30 min and were not significant at 60 min incubation. These data obtained from normal cells concur with our previous conclusions, that reductions in the rate of loss of antigenicity in nondiseased cells isolated from patients with melanoma and dysplastic naevus syndrome reflect genetic abnormalities in these patients.

  19. Risk Factors in Normal-Tension Glaucoma and High-Tension Glaucoma in relation to Polymorphisms of Endothelin-1 Gene and Endothelin-1 Receptor Type A Gene

    Directory of Open Access Journals (Sweden)

    Dominika Wróbel-Dudzińska

    2015-01-01

    Full Text Available The aim of the research is to analyse the influence of polymorphisms of endothelin-1 gene and endothelin-1 receptor type A gene on the clinical condition of patients with primary open angle glaucoma. Methods. 285 Polish patients took part in the research (160 normal-tension glaucoma and 125 high-tension glaucoma. DNA was isolated by standard methods and genotype distributions of four polymorphisms in genes encoding endothelin-1 (K198N and endothelin-1 receptor type A polymorphisms (C1222T, C70G, and G231A were determined. Genotype distributions were compared between NTG and HTG groups. The clinical condition of participants was examined for association with polymorphisms. Results. A similar frequency of occurrence of the polymorphic varieties of the studied genes was observed in patients with NTG and HTG. There is no relation between NTG risk factors and examined polymorphisms. NTG patients with TT genotype of K198N polymorphism presented with the lowest intraocular pressure in comparison to GG + GT genotype (p=0.03. In NTG patients with CC genotype of C1222T polymorphism (p=0.028 and GG of C70G polymorphism (p=0.03 the lowest values of mean blood pressure were observed. Conclusions. The studied polymorphic varieties (K198N, C1222T do have an influence on intraocular pressure as well as arterial blood pressure in NTG patients.

  20. Variation of normal tissue complication probability (NTCP) estimates of radiation-induced hypothyroidism in relation to changes in delineation of the thyroid gland

    DEFF Research Database (Denmark)

    Rønjom, Marianne Feen; Brink, Carsten; Laugaard Lorenzen, Ebbe

    2015-01-01

    Background. To examine the variations of risk-estimates of radiation-induced hypothyroidism (HT) from our previously developed normal tissue complication probability (NTCP) model in patients with head and neck squamous cell carcinoma (HNSCC) in relation to variability of delineation of the thyroid...... gland. Patients and methods. In a previous study for development of an NTCP model for HT, the thyroid gland was delineated in 246 treatment plans of patients with HNSCC. Fifty of these plans were randomly chosen for re-delineation for a study of the intra- and inter-observer variability of thyroid......-observer variability resulted in a mean difference in thyroid volume and Dmean of 0.4 cm(3) (SD ± 1.6) and -0.5 Gy (SD ± 1.0), respectively, and 0.3 cm(3) (SD ± 1.8) and 0.0 Gy (SD ± 1.3) for inter-observer variability. The corresponding mean differences of NTCP values for radiation-induced HT due to intra- and inter...

  1. The concurrent use of three implicit measures (eye movements, pupillometry, and event-related potentials) to assess receptive vocabulary knowledge in normal adults.

    Science.gov (United States)

    Ledoux, Kerry; Coderre, Emily; Bosley, Laura; Buz, Esteban; Gangopadhyay, Ishanti; Gordon, Barry

    2016-03-01

    Recent years have seen the advent and proliferation of the use of implicit techniques to study learning and cognition. One such application is the use of event-related potentials (ERPs) to assess receptive vocabulary knowledge. Other implicit assessment techniques that may be well-suited to other testing situations or to use with varied participant groups have not been used as widely to study receptive vocabulary knowledge. We sought to develop additional implicit techniques to study receptive vocabulary knowledge that could augment the knowledge gained from the use of the ERP technique. Specifically, we used a simple forced-choice paradigm to assess receptive vocabulary knowledge in normal adult participants using eye movement monitoring (EM) and pupillometry. In the same group of participants, we also used an N400 semantic incongruity ERP paradigm to assess their knowledge of two groups of words: those expected to be known to the participants (high-frequency, familiar words) and those expected to be unknown (low-frequency, unfamiliar words). All three measures showed reliable differences between the known and unknown words. EM and pupillometry thus may provide insight into receptive vocabulary knowledge similar to that from ERPs. The development of additional implicit assessment techniques may increase the feasibility of receptive vocabulary testing across a wider range of participant groups and testing situations, and may make the conduct of such testing more accessible to a wider range of researchers, clinicians, and educators.

  2. Vector Lattice Vortex Solitons

    Institute of Scientific and Technical Information of China (English)

    WANG Jian-Dong; YE Fang-Wei; DONG Liang-Wei; LI Yong-Ping

    2005-01-01

    @@ Two-dimensional vector vortex solitons in harmonic optical lattices are investigated. The stability properties of such solitons are closely connected to the lattice depth Vo. For small Vo, vector vortex solitons with the total zero-angular momentum are more stable than those with the total nonzero-angular momentum, while for large Vo, this case is inversed. If Vo is large enough, both the types of such solitons are stable.

  3. Support vector machines applications

    CERN Document Server

    Guo, Guodong

    2014-01-01

    Support vector machines (SVM) have both a solid mathematical background and good performance in practical applications. This book focuses on the recent advances and applications of the SVM in different areas, such as image processing, medical practice, computer vision, pattern recognition, machine learning, applied statistics, business intelligence, and artificial intelligence. The aim of this book is to create a comprehensive source on support vector machine applications, especially some recent advances.

  4. Viruses vector control proposal: genus Aedes emphasis

    Directory of Open Access Journals (Sweden)

    Nelson Nogueira Reis

    Full Text Available Abstract The dengue fever is a major public health problem in the world. In Brazil, in 2015, there were 1,534,932 cases, being 20,320 cases of severe form, and 811 deaths related to this disease. The distribution of Aedes aegypti, the vector, is extensive. Recently, Zika and Chikungunya viruses had arisen, sharing the same vector as dengue and became a huge public health issue. Without specific treatment, it is urgently required as an effective vector control. This article is focused on reviewing vector control strategies, their effectiveness, viability and economical impact. Among all, the Sterile Insect Technique is highlighted as the best option to be adopted in Brazil, once it is largely effectively used in the USA and Mexico for plagues related to agribusiness.

  5. The Vector Curvaton

    CERN Document Server

    Navarro, Andres A

    2013-01-01

    We analyze a massive vector field with a non-canonical kinetic term in the action, minimally coupled to gravity, where the mass and kinetic function of the vector field vary as functions of time during inflation. The vector field is introduced following the same idea of a scalar curvaton, which must not affect the inflationary dynamics since its energy density during inflation is negligible compared to the total energy density in the Universe. Using this hypothesis, the vector curvaton will be solely responsible for generating the primordial curvature perturbation \\zeta. We have found that the spectra of the vector field perturbations are scale-invariant in superhorizon scales due to the suitable choice of the time dependence of the kinetic function and the effective mass during inflation. The preferred direction, generated by the vector field, makes the spectrum of \\zeta depend on the wavevector, i.e. there exists statistical anisotropy in \\zeta. This is discussed principally in the case where the mass of th...

  6. Evaluation of Raman spectra of human brain tumor tissue using the learning vector quantization neural network

    Science.gov (United States)

    Liu, Tuo; Chen, Changshui; Shi, Xingzhe; Liu, Chengyong

    2016-05-01

    The Raman spectra of tissue of 20 brain tumor patients was recorded using a confocal microlaser Raman spectroscope with 785 nm excitation in vitro. A total of 133 spectra were investigated. Spectra peaks from normal white matter tissue and tumor tissue were analyzed. Algorithms, such as principal component analysis, linear discriminant analysis, and the support vector machine, are commonly used to analyze spectral data. However, in this study, we employed the learning vector quantization (LVQ) neural network, which is typically used for pattern recognition. By applying the proposed method, a normal diagnosis accuracy of 85.7% and a glioma diagnosis accuracy of 89.5% were achieved. The LVQ neural network is a recent approach to excavating Raman spectra information. Moreover, it is fast and convenient, does not require the spectra peak counterpart, and achieves a relatively high accuracy. It can be used in brain tumor prognostics and in helping to optimize the cutting margins of gliomas.

  7. Free and Cued Memory in relation to Biomarker-Defined Abnormalities in Clinically Normal Older Adults and Those at Risk for Alzheimer’s Disease

    Science.gov (United States)

    Papp, Kathryn V.; Amariglio, Rebecca E.; Mormino, Elizabeth; Hedden, Trey; Dekhytar, Maria; Johnson, Keith A.; Sperling, Reisa A.; Rentz, Dorene M.

    2015-01-01

    Objectives Furthering our understanding of the relationship between amyloidosis (Aβ), neurodegeneration (ND), and cognition is imperative for early identification and early intervention of Alzheimer’s disease (AD). However, the subtle cognitive decline differentially associated with each biomarker-defined stage of preclinical AD has yet to be fully characterized. Recent work indicates that different components of memory performance (free and cued recall) may be differentially specific to memory decline in prodromal AD. We sought to examine the relationship between free and cued recall paradigms, in addition to global composites of memory, executive functioning, and processing speed in relation to stages of preclinical AD. Methods A total of 260 clinically normal (CN) older adults (CDR=0) from the Harvard Aging Brain study were grouped according to preclinical AD stages including Stage 0 (Aβ−/ND−), Stage 1 (Aβ+/ND−), Stage 2 (Aβ+/ND+), and suspected non-Alzheimer’s associated pathology (SNAP; Aβ−/ND+). General linear models controlling for age, sex, and education were used to assess for stage-based performance differences on cognitive composites of executive functioning, processing speed, and memory in addition to free and cued delayed recall on the Selective Reminding Test (SRT) and Memory Capacity Test (MCT). Results Global memory performance differed between preclinical stages with Stage 2 performing worse compared with Stage 0. When examining free and cued paradigms by memory test, only the MCT (and not the SRT) revealed group differences. More specifically, Stage 1 was associated with decrements in free recall compared with Stage 0 while Stage 2 was associated with decrements in both free and cued recall. There was a trend for the SNAP group to perform worse on free recall compared with Stage 0. Finally, there was no association between preclinical stage and global composites of executive functioning or processing speed. Conclusions Clinically

  8. Nonperturbative Aspects of Axial Vector Vertex

    Institute of Scientific and Technical Information of China (English)

    ZONG Hong-Shi; CHEN Xiang-Song; WANG Fan; CHANG Chao-Hsi; ZHAO En-Guang

    2002-01-01

    It is shown how the axial vector current of current quarks is related to that of constituent quarks within the framework of the global color symmetry model.Gluon dressing of the axial vector vertex and the quark self-energy functions are described by the inhomogeneous Bethe-Salpeter equation in the ladder approximation and the Schwinger Dyson equation in the rainbow approximation,respectively.

  9. SMOOTH CLASSIFICATION AND LINEARIZATION OF HYPERBOLIC VECTOR FIELDS ON R~3

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    This paper is devoted to studying smooth normal form theory of hyperbolic vector fields. As a continuation of our previous work on smooth classification and linearization of vector fields near a hyperbolic singular point,in this paper,we deal with the case of hyperbolic vector fields on R3 by examining all possible resonant classes.

  10. SMOOTH CLASSIFICATION AND LINEARIZATION OF HYPERBOLIC VECTOR FIELDS ON R3

    Institute of Scientific and Technical Information of China (English)

    Zhihua Ren

    2009-01-01

    This paper is devoted to studying smooth normal form theory of hyperbolic vector fields. As a continuation of our previous work on smooth classification and lineariza-tion of vector fields near a hyperbolic singular point,in this paper,we deal with the case of hyperbolic vector fields on R3 by examining all possible resonant classes.

  11. Ovitrap surveys of dengue vector mosquitoes in Chiang Mai, northern Thailand: seasonal shifts in relative abundance of Aedes albopictus and Ae. aegypti.

    Science.gov (United States)

    Mogi, M; Khamboonruang, C; Choochote, W; Suwanpanit, P

    1988-10-01

    Aedes aegypti (L.) and Aedes albopictus (Skuse) were surveyed using ovitraps in residential areas in Chiang Mai, northern Thailand. Egg populations (both species inclusive) remained low in the dry season, but increased/decreased exponentially during the first/latter half of the rainy season, respectively. This seasonal pattern was similar to the seasonal distribution of dengue haemorrhagic fever cases in the area. During the dry season (November-March) Ae.aegypti was dominant in urban and indoor ovitraps. With onset of the rainy season in April, relative abundance of Ae.albopictus increased in rural and outdoor ovitraps. Ae.albopictus displaced Ae.aegypti in the latter half of the rainy season in the rural area. Possible mechanisms to account for this seasonal decline of Ae.aegypti and reciprocal fluctuations in relative abundance of Ae.albopictus are discussed in relation to food availability for larvae in container habitats.

  12. Vector cross product in n-dimensional vector space

    OpenAIRE

    Tian, Xiu-Lao; Yang, Chao; Hu, Yang; Tian, Chao

    2013-01-01

    The definition of vector cross product (VCP) introduced by Eckmann only exists in thethree- and the seven- dimensional vector space. In this paper, according to the orthogonal completeness, magnitude of basis vector cross product and all kinds of combinations of basis vector $\\hat{e}_i$, the generalized definition of VCP in the odd n-dimensional vector space is given by introducing a cross term $X_{AB}$. In addition, the definition is validated by reducing the generalization definition to the...

  13. Evaluation of Methods for Sampling the Malaria Vector Anopheles darlingi (Diptera, Culicidae) in Suriname and the Relation With Its Biting Behavior

    NARCIS (Netherlands)

    Hiwat-van Laar, H.; Rijk, de M.; Andriessen, R.; Koenraadt, C.J.M.; Takken, W.

    2011-01-01

    The effectiveness of CO2-baited and human-baited mosquito traps for the sampling of Anopheles darlingi Root was evaluated and compared with human landing collections in Suriname. Biting preferences of this mosquito on a human host were studied and related to trapping data. Traps used were the Center

  14. Construction and characterization of normalized cDNA libraries by 454 pyrosequencing and estimation of DNA methylation levels in three distantly related termite species.

    Directory of Open Access Journals (Sweden)

    Yoshinobu Hayashi

    Full Text Available In termites, division of labor among castes, categories of individuals that perform specialized tasks, increases colony-level productivity and is the key to their ecological success. Although molecular studies on caste polymorphism have been performed in termites, we are far from a comprehensive understanding of the molecular basis of this phenomenon. To facilitate future molecular studies, we aimed to construct expressed sequence tag (EST libraries covering wide ranges of gene repertoires in three representative termite species, Hodotermopsis sjostedti, Reticulitermes speratus and Nasutitermes takasagoensis. We generated normalized cDNA libraries from whole bodies, except for guts containing microbes, of almost all castes, sexes and developmental stages and sequenced them with the 454 GS FLX titanium system. We obtained >1.2 million quality-filtered reads yielding >400 million bases for each of the three species. Isotigs, which are analogous to individual transcripts, and singletons were produced by assembling the reads and annotated using public databases. Genes related to juvenile hormone, which plays crucial roles in caste differentiation of termites, were identified from the EST libraries by BLAST search. To explore the potential for DNA methylation, which plays an important role in caste differentiation of honeybees, tBLASTn searches for DNA methyltransferases (dnmt1, dnmt2 and dnmt3 and methyl-CpG binding domain (mbd were performed against the EST libraries. All four of these genes were found in the H. sjostedti library, while all except dnmt3 were found in R. speratus and N. takasagoensis. The ratio of the observed to the expected CpG content (CpG O/E, which is a proxy for DNA methylation level, was calculated for the coding sequences predicted from the isotigs and singletons. In all of the three species, the majority of coding sequences showed depletion of CpG O/E (less than 1, and the distributions of CpG O/E were bimodal, suggesting

  15. Simulation of salinity variability and the related freshwater flux forcing in the tropical Pacific: An evaluation using the Beijing normal university earth system model (BNU-ESM)

    Science.gov (United States)

    Zhi, Hai; Zhang, Rong-Hua; Lin, Pengfei; Wang, Lanning

    2015-11-01

    The climatology and interannual variability of sea surface salinity (SSS) and freshwater flux (FWF) in the equatorial Pacific are analyzed and evaluated using simulations from the Beijing Normal University Earth System Model (BNU-ESM). The simulated annual climatology and interannual variations of SSS, FWF, mixed layer depth (MLD), and buoyancy flux agree with those observed in the equatorial Pacific. The relationships among the interannual anomaly fields simulated by BNU-ESM are analyzed to illustrate the climate feedbacks induced by FWF in the tropical Pacific. The largest interannual variations of SSS and FWF are located in the western-central equatorial Pacific. A positive FWF feedback effect on sea surface temperature (SST) in the equatorial Pacific is identified. As a response to El Niño-Southern Oscillation (ENSO), the interannual variation of FWF induces ocean processes which, in turn, enhance ENSO. During El Niño, a positive FWF anomaly in the western-central Pacific (an indication of increased precipitation rates) acts to enhance a negative salinity anomaly and a negative surface ocean density anomaly, leading to stable stratification in the upper ocean. Hence, the vertical mixing and entrainment of subsurface water into the mixed layer are reduced, and the associated El Niño is enhanced. Related to this positive feedback, the simulated FWF bias is clearly reflected in SSS and SST simulations, with a positive FWF perturbation into the ocean corresponding to a low SSS and a small surface ocean density in the western-central equatorial Pacific warm pool.

  16. An Assessment of Polynomial Regression Techniques for the Relative Radiometric Normalization (RRN of High-Resolution Multi-Temporal Airborne Thermal Infrared (TIR Imagery

    Directory of Open Access Journals (Sweden)

    Mir Mustafizur Rahman

    2014-11-01

    Full Text Available Thermal Infrared (TIR remote sensing images of urban environments are increasingly available from airborne and satellite platforms. However, limited access to high-spatial resolution (H-res: ~1 m TIR satellite images requires the use of TIR airborne sensors for mapping large complex urban surfaces, especially at micro-scales. A critical limitation of such H-res mapping is the need to acquire a large scene composed of multiple flight lines and mosaic them together. This results in the same scene components (e.g., roads, buildings, green space and water exhibiting different temperatures in different flight lines. To mitigate these effects, linear relative radiometric normalization (RRN techniques are often applied. However, the Earth’s surface is composed of features whose thermal behaviour is characterized by complexity and non-linearity. Therefore, we hypothesize that non-linear RRN techniques should demonstrate increased radiometric agreement over similar linear techniques. To test this hypothesis, this paper evaluates four (linear and non-linear RRN techniques, including: (i histogram matching (HM; (ii pseudo-invariant feature-based polynomial regression (PIF_Poly; (iii no-change stratified random sample-based linear regression (NCSRS_Lin; and (iv no-change stratified random sample-based polynomial regression (NCSRS_Poly; two of which (ii and iv are newly proposed non-linear techniques. When applied over two adjacent flight lines (~70 km2 of TABI-1800 airborne data, visual and statistical results show that both new non-linear techniques improved radiometric agreement over the previously evaluated linear techniques, with the new fully-automated method, NCSRS-based polynomial regression, providing the highest improvement in radiometric agreement between the master and the slave images, at ~56%. This is ~5% higher than the best previously evaluated linear technique (NCSRS-based linear regression.

  17. Construction and characterization of normalized cDNA libraries by 454 pyrosequencing and estimation of DNA methylation levels in three distantly related termite species.

    Science.gov (United States)

    Hayashi, Yoshinobu; Shigenobu, Shuji; Watanabe, Dai; Toga, Kouhei; Saiki, Ryota; Shimada, Keisuke; Bourguignon, Thomas; Lo, Nathan; Hojo, Masaru; Maekawa, Kiyoto; Miura, Toru

    2013-01-01

    In termites, division of labor among castes, categories of individuals that perform specialized tasks, increases colony-level productivity and is the key to their ecological success. Although molecular studies on caste polymorphism have been performed in termites, we are far from a comprehensive understanding of the molecular basis of this phenomenon. To facilitate future molecular studies, we aimed to construct expressed sequence tag (EST) libraries covering wide ranges of gene repertoires in three representative termite species, Hodotermopsis sjostedti, Reticulitermes speratus and Nasutitermes takasagoensis. We generated normalized cDNA libraries from whole bodies, except for guts containing microbes, of almost all castes, sexes and developmental stages and sequenced them with the 454 GS FLX titanium system. We obtained >1.2 million quality-filtered reads yielding >400 million bases for each of the three species. Isotigs, which are analogous to individual transcripts, and singletons were produced by assembling the reads and annotated using public databases. Genes related to juvenile hormone, which plays crucial roles in caste differentiation of termites, were identified from the EST libraries by BLAST search. To explore the potential for DNA methylation, which plays an important role in caste differentiation of honeybees, tBLASTn searches for DNA methyltransferases (dnmt1, dnmt2 and dnmt3) and methyl-CpG binding domain (mbd) were performed against the EST libraries. All four of these genes were found in the H. sjostedti library, while all except dnmt3 were found in R. speratus and N. takasagoensis. The ratio of the observed to the expected CpG content (CpG O/E), which is a proxy for DNA methylation level, was calculated for the coding sequences predicted from the isotigs and singletons. In all of the three species, the majority of coding sequences showed depletion of CpG O/E (less than 1), and the distributions of CpG O/E were bimodal, suggesting the presence of

  18. Scientific Opinion on the substantiation of a health claim related to iodine and contribution to normal thyroid function pursuant to Article 14 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2014-01-01

    Full Text Available Following an application from Specialised Nutrition Europe (formerly IDACE, submitted pursuant to Article 14 of Regulation (EC No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to iodine and contribution to normal thyroid function. The food constituent, iodine, which is the subject of the health claim, is sufficiently characterised. Contribution to normal thyroid function is a beneficial physiological effect for infants and young children. A claim on iodine and normal thyroid function in the general population has already been assessed with a favourable outcome. The Panel considers that the role of iodine on normal thyroid function applies to all ages, including infants and young children (from birth to three years. The Panel concludes that a cause and effect relationship has been established between the dietary intake of iodine and contribution to normal thyroid function.

  19. Extended Mixed Vector Equilibrium Problems

    Directory of Open Access Journals (Sweden)

    Mijanur Rahaman

    2014-01-01

    Full Text Available We study extended mixed vector equilibrium problems, namely, extended weak mixed vector equilibrium problem and extended strong mixed vector equilibrium problem in Hausdorff topological vector spaces. Using generalized KKM-Fan theorem (Ben-El-Mechaiekh et al.; 2005, some existence results for both problems are proved in noncompact domain.

  20. Large Animal Models for Foamy Virus Vector Gene Therapy

    Directory of Open Access Journals (Sweden)

    Peter A. Horn

    2012-12-01

    Full Text Available Foamy virus (FV vectors have shown great promise for hematopoietic stem cell (HSC gene therapy. Their ability to efficiently deliver transgenes to multi-lineage long-term repopulating cells in large animal models suggests they will be effective for several human hematopoietic diseases. Here, we review FV vector studies in large animal models, including the use of FV vectors with the mutant O6-methylguanine-DNA methyltransferase, MGMTP140K to increase the number of genetically modified cells after transplantation. In these studies, FV vectors have mediated efficient gene transfer to polyclonal repopulating cells using short ex vivo transduction protocols designed to minimize the negative effects of ex vivo culture on stem cell engraftment. In this regard, FV vectors appear superior to gammaretroviral vectors, which require longer ex vivo culture to effect efficient transduction. FV vectors have also compared favorably with lentiviral vectors when directly compared in the dog model. FV vectors have corrected leukocyte adhesion deficiency and pyruvate kinase deficiency in the dog large animal model. FV vectors also appear safer than gammaretroviral vectors based on a reduced frequency of integrants near promoters and also near proto-oncogenes in canine repopulating cells. Together, these studies suggest that FV vectors should be highly effective for several human hematopoietic diseases, including those that will require relatively high percentages of gene-modified cells to achieve clinical benefit.

  1. Scalable motion vector coding

    Science.gov (United States)

    Barbarien, Joeri; Munteanu, Adrian; Verdicchio, Fabio; Andreopoulos, Yiannis; Cornelis, Jan P.; Schelkens, Peter

    2004-11-01

    Modern video coding applications require transmission of video data over variable-bandwidth channels to a variety of terminals with different screen resolutions and available computational power. Scalable video coding is needed to optimally support these applications. Recently proposed wavelet-based video codecs employing spatial domain motion compensated temporal filtering (SDMCTF) provide quality, resolution and frame-rate scalability while delivering compression performance comparable to that of the state-of-the-art non-scalable H.264-codec. These codecs require scalable coding of the motion vectors in order to support a large range of bit-rates with optimal compression efficiency. Scalable motion vector coding algorithms based on the integer wavelet transform followed by embedded coding of the wavelet coefficients were recently proposed. In this paper, a new and fundamentally different scalable motion vector codec (MVC) using median-based motion vector prediction is proposed. Extensive experimental results demonstrate that the proposed MVC systematically outperforms the wavelet-based state-of-the-art solutions. To be able to take advantage of the proposed scalable MVC, a rate allocation mechanism capable of optimally dividing the available rate among texture and motion information is required. Two rate allocation strategies are proposed and compared. The proposed MVC and rate allocation schemes are incorporated into an SDMCTF-based video codec and the benefits of scalable motion vector coding are experimentally demonstrated.

  2. The light filament as vector solitary wave

    CERN Document Server

    Kovachev, Lubomir M

    2015-01-01

    We present an analytical approach to the theory of nonlinear propagation of femtosecond optical pulses with broad-band spectrum in gases. The vector character of the nonlinear third-order polarization is investigated in details, taking into account the carrier to envelope phase. The corresponding system of vector amplitude equations is written by using left-hand and right-hand circular components of the electrical field. We found that this system nonlinear equations admits $3D+1$ vector soliton solution with Lorentz shape. The solution presents relatively stable propagation and rotation with GHz frequency of the vector of the electrical field in plane, orthogonal to the direction of propagation. The evolution of the intensity profile demonstrate weak self-compression and week spherical wave in the first milliseconds of propagation.

  3. Vector Fields on Product Manifolds

    CERN Document Server

    Kurz, Stefan

    2011-01-01

    This short report establishes some basic properties of smooth vector fields on product manifolds. The main results are: (i) On a product manifold there always exists a direct sum decomposition into horizontal and vertical vector fields. (ii) Horizontal and vertical vector fields are naturally isomorphic to smooth families of vector fields defined on the factors. Vector fields are regarded as derivations of the algebra of smooth functions.

  4. Robustifying Vector Median Filter

    Directory of Open Access Journals (Sweden)

    Valentín Gregori

    2011-08-01

    Full Text Available This paper describes two methods for impulse noise reduction in colour images that outperform the vector median filter from the noise reduction capability point of view. Both methods work by determining first the vector median in a given filtering window. Then, the use of complimentary information from componentwise analysis allows to build robust outputs from more reliable components. The correlation among the colour channels is taken into account in the processing and, as a result, a more robust filter able to process colour images without introducing colour artifacts is obtained. Experimental results show that the images filtered with the proposed method contain less noisy pixels than those obtained through the vector median filter. Objective measures demonstrate the goodness of the achieved improvement.

  5. Boosting Support Vector Machines

    Directory of Open Access Journals (Sweden)

    Elkin Eduardo García Díaz

    2006-11-01

    Full Text Available En este artículo, se presenta un algoritmo de clasificación binaria basado en Support Vector Machines (Máquinas de Vectores de Soporte que combinado apropiadamente con técnicas de Boosting consigue un mejor desempeño en cuanto a tiempo de entrenamiento y conserva características similares de generalización con un modelo de igual complejidad pero de representación más compacta./ In this paper we present an algorithm of binary classification based on Support Vector Machines. It is combined with a modified Boosting algorithm. It run faster than the original SVM algorithm with a similar generalization error and equal complexity model but it has more compact representation.

  6. Scalar-Vector Bootstrap

    CERN Document Server

    Rejon-Barrera, Fernando

    2015-01-01

    We work out all of the details required for implementation of the conformal bootstrap program applied to the four-point function of two scalars and two vectors in an abstract conformal field theory in arbitrary dimension. This includes a review of which tensor structures make appearances, a construction of the projectors onto the required mixed symmetry representations, and a computation of the conformal blocks for all possible operators which can be exchanged. These blocks are presented as differential operators acting upon the previously known scalar conformal blocks. Finally, we set up the bootstrap equations which implement crossing symmetry. Special attention is given to the case of conserved vectors, where several simplifications occur.

  7. Scalar-vector bootstrap

    Energy Technology Data Exchange (ETDEWEB)

    Rejon-Barrera, Fernando [Institute for Theoretical Physics, University of Amsterdam,Science Park 904, Postbus 94485, 1090 GL, Amsterdam (Netherlands); Robbins, Daniel [Department of Physics, Texas A& M University,TAMU 4242, College Station, TX 77843 (United States)

    2016-01-22

    We work out all of the details required for implementation of the conformal bootstrap program applied to the four-point function of two scalars and two vectors in an abstract conformal field theory in arbitrary dimension. This includes a review of which tensor structures make appearances, a construction of the projectors onto the required mixed symmetry representations, and a computation of the conformal blocks for all possible operators which can be exchanged. These blocks are presented as differential operators acting upon the previously known scalar conformal blocks. Finally, we set up the bootstrap equations which implement crossing symmetry. Special attention is given to the case of conserved vectors, where several simplifications occur.

  8. Topological vector spaces

    CERN Document Server

    Narici, Lawrence

    2011-01-01

    BackgroundTopology Valuation Theory Algebra Linear Functionals Hyperplanes Measure Theory Normed SpacesCommutative Topological GroupsElementary ConsiderationsSeparation and Compactness Bases at 0 for Group Topologies Subgroups and Products Quotients S-Topologies Metrizability CompletenessCompleteness Function Groups Total BoundednessCompactness and Total Boundedness Uniform Continuity Extension of Uniformly Continuous Maps CompletionTopological Vector SpacesAbsorbent and Balanced Sets Convexity-AlgebraicBasic PropertiesConvexity-Topological Generating Vector Topologies A Non-Locally Convex Spa

  9. Matrix vector analysis

    CERN Document Server

    Eisenman, Richard L

    2005-01-01

    This outstanding text and reference applies matrix ideas to vector methods, using physical ideas to illustrate and motivate mathematical concepts but employing a mathematical continuity of development rather than a physical approach. The author, who taught at the U.S. Air Force Academy, dispenses with the artificial barrier between vectors and matrices--and more generally, between pure and applied mathematics.Motivated examples introduce each idea, with interpretations of physical, algebraic, and geometric contexts, in addition to generalizations to theorems that reflect the essential structur

  10. Free topological vector spaces

    OpenAIRE

    Gabriyelyan, Saak S.; Morris, Sidney A.

    2016-01-01

    We define and study the free topological vector space $\\mathbb{V}(X)$ over a Tychonoff space $X$. We prove that $\\mathbb{V}(X)$ is a $k_\\omega$-space if and only if $X$ is a $k_\\omega$-space. If $X$ is infinite, then $\\mathbb{V}(X)$ contains a closed vector subspace which is topologically isomorphic to $\\mathbb{V}(\\mathbb{N})$. It is proved that if $X$ is a $k$-space, then $\\mathbb{V}(X)$ is locally convex if and only if $X$ is discrete and countable. If $X$ is a metrizable space it is shown ...

  11. Duality in vector optimization

    CERN Document Server

    Bot, Radu Ioan

    2009-01-01

    This book presents fundamentals and comprehensive results regarding duality for scalar, vector and set-valued optimization problems in a general setting. After a preliminary chapter dedicated to convex analysis and minimality notions of sets with respect to partial orderings induced by convex cones a chapter on scalar conjugate duality follows. Then investigations on vector duality based on scalar conjugacy are made. Weak, strong and converse duality statements are delivered and connections to classical results from the literature are emphasized. One chapter is exclusively consecrated to the s

  12. Normal modal preferential consequence

    CSIR Research Space (South Africa)

    Britz, K

    2012-12-01

    Full Text Available of necessitation holds for the corresponding consequence relations, as one would expect it to. We present a representation result for this tightened framework, and investigate appropriate notions of entailment in this context|normal entailment, and a rational...

  13. Classification of Boar Sperm Head Images using Learning Vector Quantization

    NARCIS (Netherlands)

    Biehl, Michael; Pasma, Piter; Pijl, Marten; Sánchez, Lidia; Petkov, Nicolai; Verleysen, Michel

    2006-01-01

    We apply Learning Vector Quantization (LVQ) in automated boar semen quality assessment. The classification of single boar sperm heads into healthy (normal) and non-normal ones is based on grey-scale microscopic images only. Sample data was classified by veterinary experts and is used for training a

  14. Two-Dimensional Numerical Simulation of the DC Glow Discharge in the Normal Mode and with Einstein's Relation of Electron Diffusivity%Two-Dimensional Numerical Simulation of the DC Glow Discharge in the Normal Mode and with Einstein's Relation of Electron Diffusivity

    Institute of Scientific and Technical Information of China (English)

    A. BOUCHIKHI

    2012-01-01

    This paper presents an investigation of a DC glow discharge at low pressure in the normal mode and with Einstein's relation of electron diffusivity. Two-dimensional distributions in Cartesian geometry are presented in the stationary state, including electric potential, electron and ion densities, longitudinal and transverse electrics fields as well as electron temperature. Our results are compared with those obtained in existing literature. The model used in this work is based on the first three moments of Boltzmann's equation. They serve as the continuity equation, the momentum transfer and the energy equations. The set of equations for charged particles presented in monatomic argon gas are coupled in a self-consistent way with Poisson's equation. A parametric study varying the cathode voltage, gas pressure, and secondary electron emission coefficient predicts many of the well-known features of DC discharges.

  15. Doppler assessment of the ratio of the systolic to diastolic duration in normal children: relation to heart rate, age and body surface area.

    Science.gov (United States)

    Sarnari, Roberto; Kamal, Reema Yousef; Friedberg, Mark K; Silverman, Norman H

    2009-08-01

    It has been shown that the ratio of systolic duration to diastolic duration (S/D) is a valuable global index of ventricular dysfunction in pediatric dilated and restrictive cardiomyopathy and is also a valuable index of the ventricular function of single systemic right ventricles in children who have undergone palliation of hypoplastic left-heart syndrome. The purposes of this study were to establish normal values for the S/D ratio in children without heart disease and to investigate its variation with heart rate (HR), age, and body surface area. Of 752 children found to have functional murmurs by clinical means, 179 (24% of the total database) had trace holosystolic tricuspid regurgitation. These patients ranged in age from 0.02 months to 19 years. For this study, the diastolic interval was defined as the period of right ventricular filling (ie, the period between 2 tricuspid regurgitant jets) and the systolic interval as the remainder of the cardiac cycle corresponding to the duration of holosystolic tricuspid regurgitation, including the periods of isovolumic contraction and relaxation. The relations between the systolic and diastolic periods and their ratio (S/D ratio) and HR, age, and body surface area were evaluated using univariate and multivariate linear regression analysis. Patient's age ranged from 0.02 months to 19 years (mean, 70.18+/-65.12 months), body surface area from 0.11 to 2.51 m2 (mean, 0.85+/-0.55 m2), and HR from 50 to 156 beats/min (mean, 96.72+/-23.19 beats/min). The systolic period ranged from 208.5 to 467 ms (mean, 314.08+/-52.57 ms) and the diastolic period from 166.5 to 809 ms (mean, 341.34+/-129.61 ms), yielding a S/D ratio ranging from 0.397 to 1.62 (mean, 0.995+/-0.23). Systolic period duration showed a linear negative decrease with increasing HR (y=1.9228x+500.05, r=-0.85). Diastolic duration decreased in an exponential fashion as HR increased (y=130,679x(-1.3232), r=-0.88). The S/D ratio correlated positively with HR (y=-1

  16. Study of comprehensive monitoring mechanisms for critical vectors and related infectious diseases%重要病媒生物及相关传染病综合监测机制探讨

    Institute of Scientific and Technical Information of China (English)

    霍新北; 郭玉红; 刘峰; 鲁亮; 吴海霞; 陈德国; 刘起勇; 康殿民; 王学军; 姜洪荣; 肖太钦; 曹官时; 赵爱华; 石长胜

    2012-01-01

    Objective To examine vectors and related disease surveillance, and improve the ability to prevent and control related infectious diseases. To integrate existing vectors-related disease surveillance and vector population density surveillance into a comprehensive monitoring mode, in order to achieve sharing and rational allocation of public health resources. Methods Four levels of comprehensive monitoring mechanisms were explored: 1) Pdisease control and prevention; 2) Municipal disease control and prevention; 3) County-level disease control and prevention; and 4) Disease control and prevention in special large-scale enterprises. Results A total of 89 Haemaphysalis longicornis, Dermacentor silvarum and Rhipicephalus sanguineus were captured during emergency monitoring. A total of 2000 Culex pipiens pattens, Cx. Tritaeniorhynchus, Anopheles sinensis and Aedes albopictus were also collected. Routine comprehensive monitoring captured 42 766 mosquitoes, including 30 871 Cx. Pipiens pallens, 10 211 Cx. Tritaeniorhynchus, 1322 An. Sinensis, 89 Ae. Albopictus, and 273 other mosquito species, accounting for 72.18%, 23.88%, 3.09%, 0.21%, 0.64%, respectively. Three hundred twenty-one mice were captured at the monitoring spots with a capture rate of 2.03%, including 131 Rattus norvegicus, 118 Mus musculus, 64 R. rattus, and 8 Apodemus agrarius, accounting for 40.81%, 36.76%, 19.94% and 2.49%, respectively. R. rattus were only caught in Jiaonan. Pathogenic surveillance during emergency monitoring found two ticks positive for pathogens and no positive mosquitoes. Specimens from conventional comprehensive monitoring were sent to the national Center for Disease Control and Prevention. Conclusion A comprehensive monitoring mechanism integrating vector-borne disease surveillance and population density monitoring could achieve the sharing of epidemic information, vectors and results of pathogen detection. This integration would have great significance to the prediction and early

  17. Spatial distribution pattern of oviposition in the mosquito Aedes aegypti in relation to urbanization in Buenos Aires: southern fringe bionomics of an introduced vector.

    Science.gov (United States)

    Carbajo, A E; Curto, S I; Schweigmann, N J

    2006-06-01

    The distribution of Aedes aegypti (L) (Diptera: Culicidae) oviposition in Buenos Aires City is spatially heterogeneous. Oviposition activity was monitored for a year with a grid of 279 traps at 850-m intervals that were serviced weekly. Geostatistics were used for the spatial analysis and generalized linear regression to model oviposition as a function of demographic and environmental variables. The proportion of weeks infested and the total number of eggs showed spatial continuity and were higher in areas that had higher densities of houses and were closer to industrial sites; they were lower in areas with higher human populations or higher densities of flats. When all sites were considered, the spatial structure showed a strong trend, but after regression, the residuals presented lower spatial dependence. When only infested sites were considered, the oviposition variables were spatially autocorrelated and the regression residuals showed little or no spatial dependence. The spatial pattern of Ae. aegypti oviposition in a highly urbanized city such as Buenos Aires seems to be related to the urbanization gradient. These urban environments might present different resource availability or continuity between patches of resources.

  18. Lyapunov, Floquet, and singular vectors for baroclinic waves

    Directory of Open Access Journals (Sweden)

    R. M. Samelson

    2001-01-01

    Full Text Available The dynamics of the growth of linear disturbances to a chaotic basic state is analyzed in an asymptotic model of weakly nonlinear, baroclinic wave-mean interaction. In this model, an ordinary differential equation for the wave amplitude is coupled to a partial differential equation for the zonal flow correction. The leading Lyapunov vector is nearly parallel to the leading Floquet vector f1 of the lowest-order unstable periodic orbit over most of the attractor. Departures of the Lyapunov vector from this orientation are primarily rotations of the vector in an approximate tangent plane to the large-scale attractor structure. Exponential growth and decay rates of the Lyapunov vector during individual Poincaré section returns are an order of magnitude larger than the Lyapunov exponent l ≈ 0.016. Relatively large deviations of the Lyapunov vector from parallel to f1 are generally associated with relatively large transient decays. The transient growth and decay of the Lyapunov vector is well described by the transient growth and decay of the leading Floquet vectors of the set of unstable periodic orbits associated with the attractor. Each of these vectors is also nearly parallel to f1. The dynamical splitting of the complete sets of Floquet vectors for the higher-order cycles follows the previous results on the lowest-order cycle, with the vectors divided into wave-dynamical and decaying zonal flow modes. Singular vectors and singular values also generally follow this split. The primary difference between the leading Lyapunov and singular vectors is the contribution of decaying, inviscidly-damped wave-dynamical structures to the singular vectors.

  19. Estimation of vector velocity

    DEFF Research Database (Denmark)

    2000-01-01

    Using a pulsed ultrasound field, the two-dimensional velocity vector can be determined with the invention. The method uses a transversally modulated ultrasound field for probing the moving medium under investigation. A modified autocorrelation approach is used in the velocity estimation. The new...

  20. Support Vector Components Analysis

    NARCIS (Netherlands)

    van der Ree, Michiel; Roerdink, Johannes; Phillips, Christophe; Garraux, Gaetan; Salmon, Eric; Wiering, Marco

    2017-01-01

    In this paper we propose a novel method for learning a distance metric in the process of training Support Vector Machines (SVMs) with the radial basis function kernel. A transformation matrix is adapted in such a way that the SVM dual objective of a classification problem is optimized. By using a wi

  1. Synthetic Space Vector Modulation

    Science.gov (United States)

    2013-06-01

    Modulation RF Radio Frequency SVM Space Vector Modulation VCO Voltage Controlled Oscillator VSI Voltage Source Inverter xvi THIS PAGE...examining the literature, an NE566 voltage controlled oscillator ( VCO ) chip as seen in Figure 10 was used to design a circuit that produced the

  2. Production of lentiviral vectors

    Directory of Open Access Journals (Sweden)

    Otto-Wilhelm Merten

    2016-01-01

    Full Text Available Lentiviral vectors (LV have seen considerably increase in use as gene therapy vectors for the treatment of acquired and inherited diseases. This review presents the state of the art of the production of these vectors with particular emphasis on their large-scale production for clinical purposes. In contrast to oncoretroviral vectors, which are produced using stable producer cell lines, clinical-grade LV are in most of the cases produced by transient transfection of 293 or 293T cells grown in cell factories. However, more recent developments, also, tend to use hollow fiber reactor, suspension culture processes, and the implementation of stable producer cell lines. As is customary for the biotech industry, rather sophisticated downstream processing protocols have been established to remove any undesirable process-derived contaminant, such as plasmid or host cell DNA or host cell proteins. This review compares published large-scale production and purification processes of LV and presents their process performances. Furthermore, developments in the domain of stable cell lines and their way to the use of production vehicles of clinical material will be presented.

  3. Vector-borne Infections

    Centers for Disease Control (CDC) Podcasts

    2011-04-18

    This podcast discusses emerging vector-borne pathogens, their role as prominent contributors to emerging infectious diseases, how they're spread, and the ineffectiveness of mosquito control methods.  Created: 4/18/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 4/27/2011.

  4. What is a vector?

    Science.gov (United States)

    Wilson, Anthony James; Morgan, Eric René; Booth, Mark; Norman, Rachel; Perkins, Sarah Elizabeth; Hauffe, Heidi Christine; Mideo, Nicole; Antonovics, Janis; McCallum, Hamish; Fenton, Andy

    2017-05-05

    Many important and rapidly emerging pathogens of humans, livestock and wildlife are 'vector-borne'. However, the term 'vector' has been applied to diverse agents in a broad range of epidemiological systems. In this perspective, we briefly review some common definitions, identify the strengths and weaknesses of each and consider the functional differences between vectors and other hosts from a range of ecological, evolutionary and public health perspectives. We then consider how the use of designations can afford insights into our understanding of epidemiological and evolutionary processes that are not otherwise apparent. We conclude that from a medical and veterinary perspective, a combination of the 'haematophagous arthropod' and 'mobility' definitions is most useful because it offers important insights into contact structure and control and emphasizes the opportunities for pathogen shifts among taxonomically similar species with similar feeding modes and internal environments. From a population dynamics and evolutionary perspective, we suggest that a combination of the 'micropredator' and 'sequential' definition is most appropriate because it captures the key aspects of transmission biology and fitness consequences for the pathogen and vector itself. However, we explicitly recognize that the value of a definition always depends on the research question under study.This article is part of the themed issue 'Opening the black box: re-examining the ecology and evolution of parasite transmission'. © 2017 The Authors.

  5. Calculus with vectors

    CERN Document Server

    Treiman, Jay S

    2014-01-01

    Calculus with Vectors grew out of a strong need for a beginning calculus textbook for undergraduates who intend to pursue careers in STEM. fields. The approach introduces vector-valued functions from the start, emphasizing the connections between one-variable and multi-variable calculus. The text includes early vectors and early transcendentals and includes a rigorous but informal approach to vectors. Examples and focused applications are well presented along with an abundance of motivating exercises. All three-dimensional graphs have rotatable versions included as extra source materials and may be freely downloaded and manipulated with Maple Player; a free Maple Player App is available for the iPad on iTunes. The approaches taken to topics such as the derivation of the derivatives of sine and cosine, the approach to limits, and the use of "tables" of integration have been modified from the standards seen in other textbooks in order to maximize the ease with which students may comprehend the material. Additio...

  6. Estimation of vector velocity

    DEFF Research Database (Denmark)

    2000-01-01

    Using a pulsed ultrasound field, the two-dimensional velocity vector can be determined with the invention. The method uses a transversally modulated ultrasound field for probing the moving medium under investigation. A modified autocorrelation approach is used in the velocity estimation. The new...

  7. Evaluation of methods for sampling the malaria vector Anopheles darlingi (Diptera, Culicidae) in Suriname and the relation with its biting behavior.

    Science.gov (United States)

    Hiwat, H; De Rijk, M; Andriessen, R; Koenraadt, C J M; Takken, W

    2011-09-01

    The effectiveness of CO2-baited and human-baited mosquito traps for the sampling of Anopheles darlingi Root was evaluated and compared with human landing collections in Suriname. Biting preferences of this mosquito on a human host were studied and related to trapping data. Traps used were the Centers for Disease Control and Prevention Miniature Light trap, the BG Sentinel mosquito trap, the Mosquito Magnet Liberty Plus mosquito trap (MM-Plus), and a custom-designed trap. Carbon dioxide and humans protected by a bed net were used as bait in the studies. The number of An. darlingi collected was greater with human landing collections than with all other collection methods. An. darlingi did not show a preference for protected humans over CO2 bait. The BG Sentinel mosquito trap with CO2 or human odor as bait and the MM-Plus proved the best alternative sampling tools for An. darlingi. The BG Sentinel mosquito trap with CO2 or human odor as bait was also very efficient at collecting Culex spp. In a field study on biting preferences of wild An. darlingi, the females showed directional biting behavior (P < 0.001), with a majority of females (93.3%) biting the lower legs and feet when approaching a seated human host. Higher efficiency of the closer-to-the-ground collecting MM-Plus and BG Sentinel mosquito trap when compared with the other trapping methods may be a result of a possible preference of this mosquito species for low-level biting. It is concluded that odor-baited sampling systems can reliably collect An. darlingi, but the odor bait needs to be improved, for instance, by including host-specific volatiles, to match live human baits.

  8. Molecular and physiological properties associated with zebra complex disease in potatoes and its relation with Candidatus Liberibacter contents in psyllid vectors.

    Directory of Open Access Journals (Sweden)

    Veria Y Alvarado

    Full Text Available Zebra complex (ZC disease on potatoes is associated with Candidatus Liberibacter solanacearum (CLs, an α-proteobacterium that resides in the plant phloem and is transmitted by the potato psyllid Bactericera cockerelli (Šulc. The name ZC originates from the brown striping in fried chips of infected tubers, but the whole plants also exhibit a variety of morphological features and symptoms for which the physiological or molecular basis are not understood. We determined that compared to healthy plants, stems of ZC-plants accumulate starch and more than three-fold total protein, including gene expression regulatory factors (e.g. cyclophilin and tuber storage proteins (e.g., patatins, indicating that ZC-affected stems are reprogrammed to exhibit tuber-like physiological properties. Furthermore, the total phenolic content in ZC potato stems was elevated two-fold, and amounts of polyphenol oxidase enzyme were also high, both serving to explain the ZC-hallmark rapid brown discoloration of air-exposed damaged tissue. Newly developed quantitative and/or conventional PCR demonstrated that the percentage of psyllids in laboratory colonies containing detectable levels of CLs and its titer could fluctuate over time with effects on colony prolificacy, but presumed reproduction-associated primary endosymbiont levels remained stable. Potato plants exposed in the laboratory to psyllid populations with relatively low-CLs content survived while exposure of plants to high-CLs psyllids rapidly culminated in a lethal collapse. In conclusion, we identified plant physiological biomarkers associated with the presence of ZC and/or CLs in the vegetative potato plant tissue and determined that the titer of CLs in the psyllid population directly affects the rate of disease development in plants.

  9. Probable slow slips in the mid-crust of Hsinchu, northwestern Taiwan: Temporal correlation between normal faulting earthquakes and relative uplift

    Science.gov (United States)

    Pu, H. C.; Lin, C. H.

    2016-05-01

    To investigate the seismic behavior of crustal deformation, we deployed a dense seismic network at the Hsinchu area of northwestern Taiwan during the period between 2004 and 2006. Based on abundant local micro-earthquakes recorded at this seismic network, we have successfully determined 274 focal mechanisms among ∼1300 seismic events. It is very interesting to see that the dominant energy of both seismic strike-slip and normal faulting mechanisms repeatedly alternated with each other within two years. Also, the strike-slip and normal faulting earthquakes were largely accompanied with the surface slipping along N60°E and uplifting obtained from the continuous GPS data, individually. Those phenomena were probably resulted by the slow uplifts at the mid-crust beneath the northwestern Taiwan area. As the deep slow uplift was active below 10 km in depth along either the boundary fault or blind fault, the push of the uplifting material would simultaneously produce both of the normal faulting earthquakes in the shallow depths (0-10 km) and the slight surface uplifting. As the deep slow uplift was stop, instead, the strike-slip faulting earthquakes would be dominated as usual due to strongly horizontal plate convergence in the Taiwan. Since the normal faulting earthquakes repeatedly dominated in every 6 or 7 months between 2004 and 2006, it may conclude that slow slip events in the mid crust were frequent to release accumulated tectonic stress in the Hsinchu area.

  10. Black holes in vector-tensor theories

    Science.gov (United States)

    Heisenberg, Lavinia; Kase, Ryotaro; Minamitsuji, Masato; Tsujikawa, Shinji

    2017-08-01

    We study static and spherically symmetric black hole (BH) solutions in second-order generalized Proca theories with nonminimal vector field derivative couplings to the Ricci scalar, the Einstein tensor, and the double dual Riemann tensor. We find concrete Lagrangians which give rise to exact BH solutions by imposing two conditions of the two identical metric components and the constant norm of the vector field. These exact solutions are described by either Reissner-Nordström (RN), stealth Schwarzschild, or extremal RN solutions with a non-trivial longitudinal mode of the vector field. We then numerically construct BH solutions without imposing these conditions. For cubic and quartic Lagrangians with power-law couplings which encompass vector Galileons as the specific cases, we show the existence of BH solutions with the difference between two non-trivial metric components. The quintic-order power-law couplings do not give rise to non-trivial BH solutions regular throughout the horizon exterior. The sixth-order and intrinsic vector-mode couplings can lead to BH solutions with a secondary hair. For all the solutions, the vector field is regular at least at the future or past horizon. The deviation from General Relativity induced by the Proca hair can be potentially tested by future measurements of gravitational waves in the nonlinear regime of gravity.

  11. Emergence and prevalence of human vector-borne diseases in sink vector populations.

    Directory of Open Access Journals (Sweden)

    Guilhem Rascalou

    Full Text Available Vector-borne diseases represent a major public health concern in most tropical and subtropical areas, and an emerging threat for more developed countries. Our understanding of the ecology, evolution and control of these diseases relies predominantly on theory and data on pathogen transmission in large self-sustaining 'source' populations of vectors representative of highly endemic areas. However, there are numerous places where environmental conditions are less favourable to vector populations, but where immigration allows them to persist. We built an epidemiological model to investigate the dynamics of six major human vector borne-diseases in such non self-sustaining 'sink' vector populations. The model was parameterized through a review of the literature, and we performed extensive sensitivity analysis to look at the emergence and prevalence of the pathogen that could be encountered in these populations. Despite the low vector abundance in typical sink populations, all six human diseases were able to spread in 15-55% of cases after accidental introduction. The rate of spread was much more strongly influenced by vector longevity, immigration and feeding rates, than by transmission and virulence of the pathogen. Prevalence in humans remained lower than 5% for dengue, leishmaniasis and Japanese encephalitis, but substantially higher for diseases with longer duration of infection; malaria and the American and African trypanosomiasis. Vector-related parameters were again the key factors, although their influence was lower than on pathogen emergence. Our results emphasize the need for ecology and evolution to be thought in the context of metapopulations made of a mosaic of sink and source habitats, and to design vector control program not only targeting areas of high vector density, but working at a larger spatial scale.

  12. Ontology for vector surveillance and management.

    Science.gov (United States)

    Lozano-Fuentes, Saul; Bandyopadhyay, Aritra; Cowell, Lindsay G; Goldfain, Albert; Eisen, Lars

    2013-01-01

    the has vector relation, of arthropod species to the pathogenic microorganisms for which they serve as biological vectors. We also recognized and addressed a potential roadblock for use of the VSMO by the vector-borne disease community: the difficulty in extracting information from OBO-Edit ontology files (*.obo files) and exporting the information to other file formats. A novel ontology explorer tool was developed to facilitate extraction and export of information from the VSMO*.obo file into lists of terms and their associated unique IDs in *.txt or *.csv file formats. These lists can then be imported into a database or data management system for use as select lists with predefined terms. This is an important step to ensure that the knowledge contained in our ontology can be put into practical use.

  13. 速度向量成像技术评价正常人左心室节段心肌收缩功能的初步研究%The preliminary research on evaluate the left ventricular segmental myocardial systolic function in normal subjects by velocity vector imaging

    Institute of Scientific and Technical Information of China (English)

    孙丽; 薛红元; 叶玉泉; 高丽; 李丽; 焦荣红

    2012-01-01

    Objective To compare left ventricular longitudinal and radial direction movement characteristic, which are of the same segments of normal myocardium under the resting state by velocity vector imaging ( WI ). Then evaluate clinical practice value of WI on normal subjects segmental systolic function. Methods Thirty healthy volunteers were enrolled, and then selected clearly apical four chamber view, apical two chamber view, apical left ventricular long axis view, axis view at papillary level, muscle level and nearly apical level. Quantitative analysis velocity ( Vs ), strain ( S ), strain rate ( SR ) about radial motion of left ventricle anterior septum, anterior, lateral wall, inferior, posterior wall and posterior septal; and longitudinal motion of normal segments from basal segment, middle segment and apical segment. Results From basal segment to apex, the velocity gradient descent as basal segment > medial segment > apical segment P 0. 05 ). Radial velocity, strain rate and strain among the different walls of the left ventricle are the same( P >0. 05 ). Conclusion This research indicates that WI can be used as quantitatively assess left ventricular segmental systolic function. To provide a new method for clinical evaluation cardiac motion and function.%目的 应用速度向量成像技术(VVI)比较静息状态下左心室相同节段的正常心肌纵向和径向的运动特点,评价VVI技术对正常人左心室节段心肌收缩功能的临床应用价值.方法 选取健康志愿者30例,采用西门子公司Sequoia 512超声诊断仪,在VVI模式下选取心尖四腔、心尖二腔、心尖左室长轴;二尖瓣水平、乳头肌水平及近心尖水平左室短轴切面,定量分析左室前间隔、前壁、侧壁、下壁、后壁及后间隔的径向运动,以及纵向的基底段、中间段及心尖段等3个分段中正常心肌节段的心肌运动速度(Vs)、应变(S)、应变率(SR).结果 正常人左心室各室壁基底段、中间段和心

  14. Discrimination thresholds of normal and anomalous trichromats: Model of senescent changes in ocular media density on the Cambridge Colour Test.

    Science.gov (United States)

    Shinomori, Keizo; Panorgias, Athanasios; Werner, John S

    2016-03-01

    Age-related changes in chromatic discrimination along dichromatic confusion lines were measured with the Cambridge Colour Test (CCT). One hundred and sixty-two individuals (16 to 88 years old) with normal Rayleigh matches were the major focus of this paper. An additional 32 anomalous trichromats classified by their Rayleigh matches were also tested. All subjects were screened to rule out abnormalities of the anterior and posterior segments. Thresholds on all three chromatic vectors measured with the CCT showed age-related increases. Protan and deutan vector thresholds increased linearly with age while the tritan vector threshold was described with a bilinear model. Analysis and modeling demonstrated that the nominal vectors of the CCT are shifted by senescent changes in ocular media density, and a method for correcting the CCT vectors is demonstrated. A correction for these shifts indicates that classification among individuals of different ages is unaffected. New vector thresholds for elderly observers and for all age groups are suggested based on calculated tolerance limits.

  15. VECTOR BUNDLE, KILLING VECTOR FIELD AND PONTRYAGIN NUMBERS

    Institute of Scientific and Technical Information of China (English)

    周建伟

    1991-01-01

    Let E be a vector bundle over a compact Riemannian manifold M. We construct a natural metric on the bundle space E and discuss the relationship between the killing vector fields of E and M. Then we give a proof of the Bott-Baum-Cheeger Theorem for vector bundle E.

  16. Potato virus X-based expression vectors are stabilized for long-term production of proteins and larger inserts.

    Science.gov (United States)

    Dickmeis, Christina; Fischer, Rainer; Commandeur, Ulrich

    2014-11-01

    Plus-strand RNA viruses such as Potato virus X (PVX) are often used as high-yielding expression vectors in plants, because they tolerate extra transgene insertion and expression without disrupting normal virus functions. However, sequence redundancy due to promoter duplication often leads to genetic instability. Although heterologous subgenomic promoter-like sequences (SGPs) have been successfully used in Tobacco mosaic virus vectors, only homologous SGP duplications have been used in PVX vectors. We stabilized PVX-based vectors by combining heterologous SGPs from related potexviruses with an N-terminal coat protein (CP) deletion. We selected two SGPs with core sequences homologous to PVX, from Bamboo mosaic virus (BaMV) and Cassava common mosaic virus, as well as a SGP with a heterologous core sequence from Foxtail mosaic virus (FoMV). We found that only the BaMV and CsCMV SGPs were utilized by the PVX replicase. However, the transgene remained unstable, due to the presence of an additional region with strong sequence similarity at the 5' end of the cp gene. The BaMV SGP combined with an N-terminal CP deletion achieved high PVX vector stability. This new expression vector is particularly useful for long-term production of proteins and for larger inserts. The improved PVX-based vectors are suitable for the systemic expression of any gene of interest in PVX host plants. The PVX-based vector can be advantageous for the overexpression of proteins, to analyze protein functions in planta or as a system for virus-induced gene silencing. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Perceived and desired weight, weight related eating and exercising behaviours, and advice received from parents among thin, overweight, obese or normal weight Australian children and adolescents

    OpenAIRE

    Amy Nancy K; O'Dea Jennifer A

    2011-01-01

    Abstract Background Thin children are less muscular, weaker, less active, and have lower performance in measures of physical fitness than their normal weight peers. Thin children are also more frequently subjected to teasing and stigmatization. Little is known about thin children's weight perceptions, desired weight and attitudes and behaviours towards food and exercise. The study aimed to compare perceived weight status, desired weight, eating and exercise behaviours and advice received from...

  18. Visual Function in Older Eyes in Normal Macular Health: Association with Incident Early Age-Related Macular Degeneration 3 Years Later

    OpenAIRE

    Owsley, Cynthia; Clark, Mark E.; Carrie E. Huisingh; Curcio, Christine A.; McGwin, Gerald

    2016-01-01

    Purpose In older eyes in normal macular health, we examined associations between impaired photopic acuity, mesopic acuity, spatial contrast sensitivity, light sensitivity, and the presence of low luminance deficit (difference between photopic and mesopic acuity) at baseline and incident AMD 3 years later. Associations were compared with an association between delayed rod-mediated dark adaptation and incident AMD, previously reported for this cohort. Methods Enrollees were 60 years or older. E...

  19. On Generalized Vector Equilibrium Problems

    Institute of Scientific and Technical Information of China (English)

    An-hua Wan; Jun-yi Fu; Wei-hua Mao

    2006-01-01

    A new generalized vector equilibrium problem involving set-valued mappings and the proper quasi-concavity of set-valued mappings in topological vector spaces are introduced; its existence theorems and the convexity of the solution sets are established.

  20. Normality in Analytical Psychology

    Directory of Open Access Journals (Sweden)

    Steve Myers

    2013-11-01

    Full Text Available Although C.G. Jung’s interest in normality wavered throughout his career, it was one of the areas he identified in later life as worthy of further research. He began his career using a definition of normality which would have been the target of Foucault’s criticism, had Foucault chosen to review Jung’s work. However, Jung then evolved his thinking to a standpoint that was more aligned to Foucault’s own. Thereafter, the post Jungian concept of normality has remained relatively undeveloped by comparison with psychoanalysis and mainstream psychology. Jung’s disjecta membra on the subject suggest that, in contemporary analytical psychology, too much focus is placed on the process of individuation to the neglect of applications that consider collective processes. Also, there is potential for useful research and development into the nature of conflict between individuals and societies, and how normal people typically develop in relation to the spectrum between individuation and collectivity.

  1. Two-vector representation of a nondepolarizing Mueller matrix

    Science.gov (United States)

    Gil, José J.; San José, Ignacio

    2016-09-01

    A geometric view of the polarimetric properties of a nondepolarizing medium is presented by means of a pair of vectors in the Poincaré sphere. An alternative representation constituted by a set of vectors contained in the equatorial plane of the Poincaré sphere is also defined and interpreted. The analyses of the magnitudes and relative orientations of the constitutive vectors of such simple representations allow for a classification of nondepolarizing media.

  2. Does the Poynting vector always represent electromagnetic power flow?

    CERN Document Server

    Wang, Changbiao

    2015-01-01

    Poynting vector as electromagnetic power flow has prevailed over one hundred years in the community. However in this paper, it is shown from Maxwell equations that the Poynting vector may not represent the electromagnetic power flow for a plane wave in a non-dispersive, lossless, non-conducting, anisotropic uniform medium; this important conclusion revises the conventional understanding of Poynting vector. It is also shown that this conclusion is clearly supported by Fermat's principle and special theory of relativity.

  3. Compact stars in vector-tensor-Horndeski theory of gravity

    Energy Technology Data Exchange (ETDEWEB)

    Momeni, Davood; Myrzakulov, Kairat; Myrzakulov, Ratbay [Eurasian National University, Department of General and Theoretical Physics, Eurasian International Center for Theoretical Physics, Astana (Kazakhstan); Faizal, Mir [University of British Columbia-Okanagan, Irving K. Barber School of Arts and Sciences, Kelowna, BC (Canada); University of Lethbridge, Department of Physics and Astronomy, Lethbridge, AB (Canada)

    2017-01-15

    In this paper, we will analyze a theory of modified gravity, in which the field content of general relativity will be increased to include a vector field. We will use the Horndeski formalism to non-minimally couple this vector field to the metric. As we will be using the Horndeski formalism, this theory will not contain Ostrogradsky ghost degree of freedom. We will analyze compact stars using this vector-tensor-Horndeski theory. (orig.)

  4. Multi-perspective views of students’ difficulties with one-dimensional vector and two-dimensional vector

    Science.gov (United States)

    Fauzi, Ahmad; Ratna Kawuri, Kunthi; Pratiwi, Retno

    2017-01-01

    Researchers of students’ conceptual change usually collects data from written tests and interviews. Moreover, reports of conceptual change often simply refer to changes in concepts, such as on a test, without any identification of the learning processes that have taken place. Research has shown that students have difficulties with vectors in university introductory physics courses and high school physics courses. In this study, we intended to explore students’ understanding of one-dimensional and two-dimensional vector in multi perspective views. In this research, we explore students’ understanding through test perspective and interviews perspective. Our research study adopted the mixed-methodology design. The participants of this research were sixty students of third semester of physics education department. The data of this research were collected by testand interviews. In this study, we divided the students’ understanding of one-dimensional vector and two-dimensional vector in two categories, namely vector skills of the addition of one-dimensionaland two-dimensional vector and the relation between vector skills and conceptual understanding. From the investigation, only 44% of students provided correct answer for vector skills of the addition of one-dimensional and two-dimensional vector and only 27% students provided correct answer for the relation between vector skills and conceptual understanding.

  5. Vector mesons in matter

    Indian Academy of Sciences (India)

    Gy Wolf

    2006-04-01

    One consequence of the chiral restoration is the mixing of parity partners. We look for a possible signature of the mixing of vector and axial vector mesons in heavy-ion collisions. We suggest an experimental method for its observation. The dynamical evolution of the heavy-ion collision is described by a transport equation of QMD-type evolving nucleons, * and resonances, ’s and $\\sum$ baryons, and furthermore, ’s, ’s ’s ’s ’s and kaons with their isospin degrees of freedom. The input cross-sections and resonance parameters of the model are fitted to the available nucleon–nucleon and pion–nucleon cross-sections.

  6. Vector fields in cosmology

    CERN Document Server

    Davydov, Evgeny

    2011-01-01

    Vector fields can arise in the cosmological context in different ways, and we discuss both abelian and nonabelian sector. In the abelian sector vector fields of the geometrical origin (from dimensional reduction and Einstein-Eddington modification of gravity) can provide a very non-trivial dynamics, which can be expressed in terms of the effective dilaton-scalar gravity with the specific potential. In the non-abelian sector we investigate the Yang-Mills SU(2) theory which admits isotropic and homogeneous configuration. Provided the non-linear dependence of the lagrangian on the invariant F*F(dual), one can obtain the inflationary regime with the exponential growth of the scale factor. The effective amplitudes of the 'electric' and 'magnetic' components behave like slowly varying scalars at this regime, what allows the consideration of some realistic models with non-linear terms in the Yang-Mills lagrangian.

  7. Helices and vector bundles

    CERN Document Server

    Rudakov, A N

    1990-01-01

    This volume is devoted to the use of helices as a method for studying exceptional vector bundles, an important and natural concept in algebraic geometry. The work arises out of a series of seminars organised in Moscow by A. N. Rudakov. The first article sets up the general machinery, and later ones explore its use in various contexts. As to be expected, the approach is concrete; the theory is considered for quadrics, ruled surfaces, K3 surfaces and P3(C).

  8. Utility of waist-to-height ratio in assessing the status of central obesity and related cardiometabolic risk profile among normal weight and overweight/obese children: The Bogalusa Heart Study

    Directory of Open Access Journals (Sweden)

    Xu Jihua

    2010-10-01

    Full Text Available Abstract Background Body Mass Index (BMI is widely used to assess the impact of obesity on cardiometabolic risk in children but it does not always relate to central obesity and varies with growth and maturation. Waist-to-Height Ratio (WHtR is a relatively constant anthropometric index of abdominal obesity across different age, sex or racial groups. However, information is scant on the utility of WHtR in assessing the status of abdominal obesity and related cardiometabolic risk profile among normal weight and overweight/obese children, categorized according to the accepted BMI threshold values. Methods Cross-sectional cardiometabolic risk factor variables on 3091 black and white children (56% white, 50% male, 4-18 years of age were used. Based on the age-, race- and sex-specific percentiles of BMI, the children were classified as normal weight (5th - 85th percentiles and overweight/obese (≥ 85th percentile. The risk profiles of each group based on the WHtR ( Results 9.2% of the children in the normal weight group were centrally obese (WHtR ≥0.5 and 19.8% among the overweight/obese were not (WHtR Conclusion WHtR not only detects central obesity and related adverse cardiometabolic risk among normal weight children, but also identifies those without such conditions among the overweight/obese children, which has implications for pediatric primary care practice.

  9. Decay Constants of Vector Mesons

    Institute of Scientific and Technical Information of China (English)

    LI Heng-Mei; WAN Shao-Long

    2008-01-01

    @@ The light vector mesons are studied within the framework of the Bethe-Salpeter equation with the vector-vectortype flat-bottom potential The Bethe-Salpeter wavefunctions and the decay constants of the vector mesons are obtained. All the obtained results, fρ, fφ, and fΚ* , are in agreement with the experimental values, respectively.

  10. Student Preconceptions about Vector Kinematics.

    Science.gov (United States)

    Aguirre, Jose M.

    1988-01-01

    Examines preconceptions regarding several implicit vector characteristics that 15- to 17-year-old students possess just before taking their first physics course. Shows seven vector characteristics and three tasks for interviewing students. Presents the most common student preconceptions regarding each of the implicit vector characteristics. (YP)

  11. Interpolation of Vector Measures

    Institute of Scientific and Technical Information of China (English)

    Ricardo del CAMPO; Antonio FERN(A)NDEZ; Fernando MAYORAL; Francisco NARANJO; Enrique A. S(A)NCHEZ-P(E)REZ

    2011-01-01

    Let (Ω, ∑) be a measurable space and m0: ∑→ X0 and m1: ∑ -→ X1 be positive vector measures with values in the Banach K(o)the function spaces X0 and X1. If 0 < α < 1, we define a X10-αXα1 and we analyze the space of integrable functions with respect to measure [m0, m1]α in order to prove suitable extensions of the classical Stein-Weiss formulas that hold for the complex interpolation of Lp-spaces.Since each p-convex order continuous K(o)the function space with weak order unit can be represented as a space of p-integrable functions with respect to a vector measure, we provide in this way a technique to obtain representations of the corresponding complex interpolation spaces. As applications, we provide a Riesz-Thorin theorem for spaces of p-integrable functions with respect to vector measures and a formula for representing the interpolation of the injective tensor product of such spaces.

  12. 向量优化中集合的一些相对代数性质和相对拓扑性质%Some relative algebraical properties and relative topological properties of sets in vector optimization

    Institute of Scientific and Technical Information of China (English)

    张万里; 林安

    2014-01-01

    In this paper, the Assumption B1 and B2 are proposed basing on the idea of Flores-Baz´an et al. The relative algebraic interior of the sum for two sets is equal to the sum of the relative algebraic interior for these sets, the sum of the algebraic closure of a set and the relative algebraic interior of a set is equal to the sum of the relative algebraic interior for the two sets, the relative topological interior of the sum for two sets is equal to the sum of the relative topological interior for these sets, the sum of topological closure of set and the relative topological interior of set is equal to the sum of the relative topological interior for the two sets are proved. Furthermore, the equivalent relations between equality of the algebraic closure and the equality of algebraic interior are established. We also obtain the similar equivalent relations for the topological closure and the relative topological interior.%基于 Flores-Baz´an 等人的思想,提出了假设 B1和假设 B2,证明了集合和的相对代数内部等于相对代数内部的和;集合代数闭包与相对代数内部的和等于和的相对代数内部;集合和的相对拓扑内部等于相对拓扑内部的和;集合拓扑闭包与相对拓扑内部的和等于和的相对拓扑内部,建立了集合代数闭包相等与代数内部相等,拓扑闭包相等与拓扑内部相等之间的一些等价关系。

  13. Neutron stars in Scalar-Tensor-Vector Gravity

    CERN Document Server

    Armengol, Federico G Lopez

    2016-01-01

    Scalar-Tensor-Vector Gravity (STVG), also referred as MOdified Gravity (MOG), is an alternative theory of the gravitational interaction. Its weak field approximation has been successfully used to described Solar System observations, galaxy rotation curves, dynamics of clusters of galaxies, and cosmological data, without the imposition of dark components. The theory was formulated by John Moffat in 2006. In this work, we derive matter-sourced solutions of STVG and construct neutron star models. We aim at exploring STVG predictions about stellar structure in the strong gravity regime. Specifically, we represent spacetime with a static, spherically symmetric manifold, and model the stellar matter content with a perfect fluid energy-momentum tensor. We then derive the modified Tolman-Oppenheimer-Volkoff equation in STVG and integrate it for different equations of state. We find that STVG allows heavier neutron stars than General Relativity (GR). Maximum masses depend on a normalized parameter that quantifies the ...

  14. Obstetric outcomes in normal weight and obese women in relation to gestational weight gain: comparison between Institute of Medicine guidelines and Cedergren criteria.

    Science.gov (United States)

    Potti, Sushma; Sliwinski, Christopher S; Jain, Neetu J; Dandolu, Vani

    2010-05-01

    We compared obstetric outcomes based on gestational weight gain in normal-weight and obese women using traditional Institute of Medicine (IOM) guidelines and newly recommended Cedergren criteria. Using the New Jersey Pregnancy Risk Assessment Monitoring System (PRAMS) database and electronic birth records, perinatal outcomes were analyzed to estimate the independent effects of prepregnancy body mass index (BMI) and gestational weight gain by IOM versus Cedergren criteria. Of 9125 subjects in PRAMS database from 2002 to 2006, 53.7% had normal BMI, 12.3% were overweight, 18.2% were obese, and the rest were underweight. Among normal-weight mothers, when compared with the IOM guidelines, macrosomia (6.45% versus 4.27%) and cesarean delivery rates (30.42% versus 29.83%) were lower using Cedergren criteria but the rates of preterm delivery (5.06% versus 9.44%), low birth weight (0.38% versus 2.42%), and neonatal intensive care unit (NICU) admissions (7.02% versus 10.86%) were higher with the Cedergren criteria. Similarly, among obese patients, when compared with IOM guidelines, macrosomia (10.79% versus 5.47%) and cesarean delivery rates (43.95% versus 40.71%) were lower using Cedergren criteria but the rates of preterm delivery (6.83% versus 8.32%), low birth weight (0.87% versus 1.88%), and NICU admissions (8.92% versus 13.78%) were higher with the Cedergren criteria. Based on our results, ideal gestational weight gain is presumably somewhere between the IOM and Cedergren's guidelines.

  15. Use of the modified viral satellite DNA vector to silence mineral nutrition-related genes in plants: silencing of the tomato ferric chelate reductase gene, FRO1, as an example

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Virus-induced gene silencing (VIGS) is potentially an attractive reverse-genetics tool for studies of plant gene function, but whether it is effective in silencing mineral nutritional-related genes in roots has not been demonstrated. Here we report on an efficient VIGS system that functions in tomato roots using a modified viral satellite DNA (DNAmβ) associated with Tomato yellow leaf curl China virus (TYLCCNV). A cDNA fragment of the ferric chelate reductase gene (FRO1) from tomato was inserted into the DNAmβ vector. Tomato roots agro-inoculated with DNAmβ carrying both a fragment of FRO1 and TYLCCNV used as a helper virus exhibited a significant reduction at the FRO1 mRNA level. As a consequence, ferric chelate reductase activity, as determined by visualization of the pink FeBPDS3 complex was significantly decreased. Our results clearly demonstrated that VIGS system can be employed to investigate gene function associated with plant nutrient uptake in roots.

  16. Use of the modified viral satellite DNA vector to silence mineral nutrition-related genes in plants: silencing of the tomato ferric chelate reductase gene, FRO1, as an example

    Institute of Scientific and Technical Information of China (English)

    HE XiuXia; JIN ChongWei; LI GuiXin; YOU GuangYi; ZHOU XuePing; ZHENG ShaoJian

    2008-01-01

    Virus-induced gene silencing (VIGS) is potentially an attractive reverse-genetics tool for studies of plant gene function, but whether it is effective in silencing mineral nutritional-related genes in roots has not been demonstrated. Here we report on an efficient VIGS system that functions in tomato roots using a modified viral satellite DNA (DNAmβ) associated with Tomato yellow leaf curl China virus (TYLCCNV). A cDNA fragment of the ferric chelate reductase gene (FRO1) from tomato was inserted into the DNAmβ vector. Tomato roots agro-inoculated with DNAmβ carrying both a fragment of FRO1 and TYLCCNV used as a helper virus exhibited a significant reduction at the FRO1 mRNA level. As a consequence, ferric chelate reductase activity, as determined by visualization of the pink FeBPDS3complex was significantly decreased. Our results clearly demonstrated that VIGS system can be employed to investigate gene function associated with plant nutrient uptake in roots.

  17. Relation of serum gamma-glutamyltransferase levels in normal range to metabolic syndrome in middle-aged and elderly Chinese women

    OpenAIRE

    Zhen-ping HU; Hua-cong DENG; Qu, Hua; Wang, Hang; Deng, Min; Hui-li WEI; Xiao-yu LI

    2013-01-01

    Objective  To explore the correlation of serum γ-glutamyltransferase (γ-GT) level in normal range to metabolic syndrome (MS) in middle-aged and elderly Chinese women. Methods  Female inhabitants aged ≥40 years in Nan'an community, Chongqing, were recruited to receive questionnaire interview and physical examination. Blood glucose, lipid, liver and kidney function profiles were also examined. A total of 1308 subjects were involved in our study, and they were divided into four groups according ...

  18. Viral Vectors for in Vivo Gene Transfer

    Science.gov (United States)

    Thévenot, E.; Dufour, N.; Déglon, N.

    The transfer of DNA into the nucleus of a eukaryotic cell (gene transfer) is a central theme of modern biology. The transfer is said to be somatic when it refers to non-germline organs of a developed individual, and germline when it concerns gametes or the fertilised egg of an animal, with the aim of transmitting the relevant genetic modification to its descendents [1]. The efficient introduction of genetic material into a somatic or germline cell and the control of its expression over time have led to major advances in understanding how genes work in vivo, i.e., in living organisms (functional genomics), but also to the development of innovative therapeutic methods (gene therapy). The efficiency of gene transfer is conditioned by the vehicle used, called the vector. Desirable features for a vector are as follows: Easy to produce high titer stocks of the vector in a reproducible way. Absence of toxicity related to transduction (transfer of genetic material into the target cell, and its expression there) and no immune reaction of the organism against the vector and/or therapeutic protein. Stability in the expression of the relevant gene over time, and the possibility of regulation, e.g., to control expression of the therapeutic protein on the physiological level, or to end expression at the end of treatment. Transduction of quiescent cells should be as efficient as transduction of dividing cells. Vectors currently used fall into two categories: non-viral and viral vectors. In non-viral vectors, the DNA is complexed with polymers, lipids, or cationic detergents (described in Chap. 3). These vectors have a low risk of toxicity and immune reaction. However, they are less efficient in vivo than viral vectors when it comes to the number of cells transduced and long-term transgene expression. (Naked DNA transfer or electroporation is rather inefficient in the organism. This type of gene transfer will not be discussed here, and the interested reader is referred to the

  19. Nonviral Vectors for Gene Delivery

    Science.gov (United States)

    Baoum, Abdulgader Ahmed

    2011-12-01

    The development of nonviral vectors for safe and efficient gene delivery has been gaining considerable attention recently. An ideal nonviral vector must protect the gene against degradation by nuclease in the extracellular matrix, internalize the plasma membrane, escape from the endosomal compartment, unpackage the gene at some point and have no detrimental effects. In comparison to viruses, nonviral vectors are relatively easy to synthesize, less immunogenic, low in cost, and have no limitation in the size of a gene that can be delivered. Significant progress has been made in the basic science and applications of various nonviral gene delivery vectors; however, the majority of nonviral approaches are still inefficient and often toxic. To this end, two nonviral gene delivery systems using either biodegradable poly(D,L-lactide- co-glycolide) (PLG) nanoparticles or cell penetrating peptide (CPP) complexes have been designed and studied using A549 human lung epithelial cells. PLG nanoparticles were optimized for gene delivery by varying particle surface chemistry using different coating materials that adsorb to the particle surface during formation. A variety of cationic coating materials were studied and compared to more conventional surfactants used for PLG nanoparticle fabrication. Nanoparticles (˜200 nm) efficiently encapsulated plasmids encoding for luciferase (80-90%) and slowly released the same for two weeks. After a delay, moderate levels of gene expression appeared at day 5 for certain positively charged PLG particles and gene expression was maintained for at least two weeks. In contrast, gene expression mediated by polyethyleneimine (PEI) ended at day 5. PLG particles were also significantly less cytotoxic than PEI suggesting the use of these vehicles for localized, sustained gene delivery to the pulmonary epithelium. On the other hand, a more simple method to synthesize 50-200 nm complexes capable of high transfection efficiency or high gene knockdown was

  20. Use of HIV as a gene transfer vector.

    Science.gov (United States)

    Pluta, Krzysztof; Kacprzak, Magdalena Marta

    2009-01-01

    Despite the extensive research efforts over the past 25 years that have focused on HIV, there is still no cure for AIDS. However, tremendous progress in the understanding of the structure and biology of the HIV virus led to the development of safe and potent HIV-based transgene delivery vectors. These genetic vehicles are referred to as lentiviral vectors. They appear to be better suited for particular applications, such as transgene delivery into stem cells, compared to other viral- and non-viral vectors. This is because Lentivirus-based vectors can efficiently infect nondividing and slowly dividing cells. In the present review article, the current state of understanding of HIV-1 is discussed and the main characteristics that had an impact on vector design are outlined. A historical view on the vector concept is presented to facilitate discussion of recent results in vector engineering in a broader context. Subsequently, a state of the art overview concerning vector construction and vector production is given. This review also touches upon the subject of lentiviral vector safety and related topics that can be helpful in addressing this issue are discussed. Finally, examples of Lentivirus-based gene delivery systems and their applications are presented, with emphasis on animal transgenesis and human gene therapy.

  1. Integrating Transgenic Vector Manipulation with Clinical Interventions to Manage Vector-Borne Diseases.

    Directory of Open Access Journals (Sweden)

    Kenichi W Okamoto

    2016-03-01

    Full Text Available Many vector-borne diseases lack effective vaccines and medications, and the limitations of traditional vector control have inspired novel approaches based on using genetic engineering to manipulate vector populations and thereby reduce transmission. Yet both the short- and long-term epidemiological effects of these transgenic strategies are highly uncertain. If neither vaccines, medications, nor transgenic strategies can by themselves suffice for managing vector-borne diseases, integrating these approaches becomes key. Here we develop a framework to evaluate how clinical interventions (i.e., vaccination and medication can be integrated with transgenic vector manipulation strategies to prevent disease invasion and reduce disease incidence. We show that the ability of clinical interventions to accelerate disease suppression can depend on the nature of the transgenic manipulation deployed (e.g., whether vector population reduction or replacement is attempted. We find that making a specific, individual strategy highly effective may not be necessary for attaining public-health objectives, provided suitable combinations can be adopted. However, we show how combining only partially effective antimicrobial drugs or vaccination with transgenic vector manipulations that merely temporarily lower vector competence can amplify disease resurgence following transient suppression. Thus, transgenic vector manipulation that cannot be sustained can have adverse consequences-consequences which ineffective clinical interventions can at best only mitigate, and at worst temporarily exacerbate. This result, which arises from differences between the time scale on which the interventions affect disease dynamics and the time scale of host population dynamics, highlights the importance of accounting for the potential delay in the effects of deploying public health strategies on long-term disease incidence. We find that for systems at the disease-endemic equilibrium, even

  2. Atomic parity violation, muon pair production in e{sup +}e{sup -} collisions, and detection of CDM WIMP. Physics related to the neutral vector boson D{sub 1}

    Energy Technology Data Exchange (ETDEWEB)

    Senju, Hirofumi [Physics Department, School of Design and Architecture, Nagoya City Univ., Nagoya (Japan)

    1999-11-01

    In our preon model there exists a neutral vector boson D{sub 1} which is an isoscalar partner of W(Z) in the vector boson octet. It is shown that the exchange of a D{sub 1} of about 1 TeV mass naturally explains a positive excess of the weak charge of atomic cesium recently observed. Other processes occurring through the D{sub 1} exchange are discussed, including the detection of CDM WIMP. (author)

  3. Normal Pressure Hydrocephalus (NPH)

    Science.gov (United States)

    ... your local chapter Join our online community Normal Pressure Hydrocephalus (NPH) Normal pressure hydrocephalus is a brain ... About Symptoms Diagnosis Causes & risks Treatments About Normal Pressure Hydrocephalus Normal pressure hydrocephalus occurs when excess cerebrospinal ...

  4. Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH.

    Science.gov (United States)

    Guo, Jun; Liu, Minlin; Yang, Dehong; Bouxsein, Mary L; Thomas, Clare C; Schipani, Ernestina; Bringhurst, F Richard; Kronenberg, Henry M

    2010-08-01

    We have previously shown that differentiation of hypertrophic chondrocytes is delayed in mice expressing a mutated PTH/PTHrP receptor (PTHR) (called DSEL here) that stimulates adenylyl cyclase normally but fails to activate phospholipase C (PLC). To better understand the role of PLC signaling via the PTHR in skeletal and mineral homeostasis, we examined these mice fed a normal or calcium-deficient diet. On a standard diet, DSEL mice displayed a modest decrease in bone mass. Remarkably, when fed a low-calcium diet or infused with PTH, DSEL mice exhibited strikingly curtailed peritrabecular stromal cell responses and attenuated new bone formation when compared with Wt mice. Attenuated in vitro colony formation was also observed in bone marrow cells derived from DSEL mice fed a low-calcium diet. Furthermore, PTH stimulated proliferation and increased mRNAs encoding cyclin D1 in primary osteoblasts derived from Wt but not from DSEL mice. Our data indicate that PLC signaling through the PTHR is required for skeletal homeostasis.

  5. Specificity of Tumor Necrosis Factor Toxicity for Human Mammary Carcinomas Relative to Normal Mammary Epithelium and Correlation with Response to Doxorubicin

    Science.gov (United States)

    Dollbaum, Charles; Creasey, Abla A.; Dairkee, Shahnaz H.; Hiller, Alan J.; Rudolph, Alfred R.; Lin, Leo; Vitt, Charles; Smith, Helene S.

    1988-07-01

    By using a unique short-term culture system capable of growing both normal and malignant breast epithelial tissue, human recombinant tumor necrosis factor (TNF) showed preferential cytotoxicity to malignant cells as compared to the corresponding nonmalignant cells. Most of the malignant specimens were sensitive to TNF with 13 of 18 specimens showing 90% inhibition of clonal growth (ID90) by TNF per ml of culture fluid. In contrast, all 13 nonmalignant specimens tested clustered at the resistant end of the TNF response spectrum, with ID90 values being >5000 units of TNF per ml of culture fluid. This differential sensitivity to TNF was seen in three cases in which malignant and nonmalignant breast epithelial tissues from the same patient were studied. To investigate the mechanism of resistance to TNF by normal cells, the presence of receptors for TNF was determined. Five of six cultures showed specific binding of 125I-labeled TNF and there was no relationship between the degree of resistance and the degree of specific binding. Simultaneous comparison of tumor responsiveness to doxorubicin and TNF revealed a positive correlation in ID90 values; these results may have important implications for the clinical use of TNF in cancer patients heavily pretreated with doxorubicin.

  6. Concurrence vectors for entanglement of high dimensional systems

    Institute of Scientific and Technical Information of China (English)

    You-quan LI; Guo-qiang ZHU

    2008-01-01

    The concurrence vectors are proposed by employing the fundamental representation of An Lie algebra,which provides a clear criterion to evaluate the entanglement of bipartite systems of arbitrary dimension.Accordingly,a state is separable if the norm of its concurrence vector vanishes.The state vectors related to SU(3)states and SO(3) states are discussed in detail.The sign situation of nonzero components of concurrence vectors of entangled bases presents a simple criterion to judge whether the whole Hilbert subspace spanned by those bases is entangled,or there exists an entanglement edge.This is illustrated in terms of the concurrence surfaces of several concrete examples.

  7. Polynomial Vector Fields in One Complex Variable

    DEFF Research Database (Denmark)

    Branner, Bodil

    In recent years Adrien Douady was interested in polynomial vector fields, both in relation to iteration theory and as a topic on their own. This talk is based on his work with Pierrette Sentenac, work of Xavier Buff and Tan Lei, and my own joint work with Kealey Dias....

  8. Bethe vectors for XXX-spin chain

    Science.gov (United States)

    Burdík, Čestmír; Fuksa, Jan; Isaev, Alexei

    2014-11-01

    The paper deals with algebraic Bethe ansatz for XXX-spin chain. Generators of Yang-Baxter algebra are expressed in basis of free fermions and used to calculate explicit form of Bethe vectors. Their relation to N-component models is used to prove conjecture about their form in general. Some remarks on inhomogeneous XXX-spin chain are included.

  9. Vectors of Crimean Congo Hemorrhagic Fever Virus in Iran

    Directory of Open Access Journals (Sweden)

    Zakkyeh Telmadarraiy

    2015-10-01

    Full Text Available Background: Ticks are important vectors and reservoirs of Crimean Congo Hemorrhagic Fever (CCHF virus. Human beings may be infected whenever the normal life cycle of the infected ticks on non- human vertebrate hosts is interrupted by the undesirable presence of humans in the cycle. A total of 26 species of Argasid and Ixodid ticks have been recorded in Iran; including nine Hyalomma, two Rhipicephalus, two Dermacentor, five Haemaphysalis, two Boophilus, one Ixodes and two Argas as well as three Ornithodoros species as blood sucking ectoparasites of livestock and poultries. The present paper reviews tick vectors of CCHF virus in Iran, focusing on the role of ticks in different provinces of Iran using reverse transcription polymerase chain reaction (RT-PCR assay.Methods: During ten years study, 1054 tick specimens; including two species of Argasidae and 17 species of Ixodidae were examined for their infection to CCHF virus genome. The output of all studies as well as related publications were discussed in the current paper.Results: The results show that Rhipicephalus sanguineus, Hyalomma marginatum, H. anatolicum, H. asiaticum and H. dromedarii were known as the most frequent species which were positive for CCHF virus.Conclusion: The status of ticks which were positive for CCHF virus revealed that unlike the most common idea that Hyalomma species are the most important vectors of CCHF virus, other ticks including Rhipicephalus,Haemaphysalis and Dermacentor can be reservoir of this virus; thus, considering geographical distribution, type of host and environmental conditions, different tick control measurements should be carried out in areas with high incidence of CCHF disease.

  10. Problem signatures from enhanced vector autoregressive modeling

    Science.gov (United States)

    Andriamanalimanana, Bruno R.; Sengupta, Saumen S.

    2001-09-01

    The work reported in this paper concerns the enhancement of mutivariate autoregressive (AR) models with geometric shape analysis data and stochastic causal relations. The study aims at producing numerical signatures characterizing operating problems, from multivariate time series of data collected in an application and operating environment domain. Since the information content of an AR model does not appear sufficient to characterize observed vector values fully, both geometric and stochastic modeling techniques are applied to refine causal inferences further. The specific application domain used for this study is real-time network traffic monitoring. However, other domains utilizing vector models might benefit as well. A partial Java implementation is being used for experimentation.

  11. Immature development of the malaria vector mosquito, Anopheles gambiae S.L. (Diptera: Culicidae), in relation to soil-substrate organic matter content of larval habitats in northcentral Nigeria.

    Science.gov (United States)

    Olayemi, I K; Ojo, V O

    2013-02-01

    This study elucidated the relationships between larval habitat soil-substrate Organic Matter Content (OMC) and immature development of the mosquito Anopheles gambiae S.L. Day-old larvae of the mosquito were reared in media substrated with typical soil samples (i.e., sandy, silt, clayey and loamy soils), from established anopheline breeding sites, to provide a gradient in soil-substrate OMC. The OMC of the soil samples were determined by ignition to a constant weight; while the developing A. gambiae mosquitoes in the culture media were monitored daily for survivorship and duration of immature life stages. The results indicated significant (p OMC of the soil types (range = 11.21 +/- 2.91% in sandy to 29.83 +/- 2.96% in loamy soils). However, though Daily Larval Survival Rates (DLSR) were relatively high (range = 95.21 +/- 2.96 to 96.70 +/- 1.44%), as influenced by OMC, such values were not significantly different (p > 0.05) among the soil-substrate types; results contrary to those of Larval Success Rates (LSR) (i.e., range = 52.07 +/- 13.64 to 74.39 +/- 6.60%). Daily Pupation Rate (DPR) of the mosquitoes varied significantly among the soil-substrates, ranging from 13.87 +/- 2.39% in clayey to 25.00 +/- 4.30% in loamy substrates. Soil-substrate OMC significantly extended the Duration of Immature Life Stages (DILS) of the mosquitoes only in the sandy soil type (range = 12.76 +/- 1.74 to 15.81 +/- 2.40 days). On the whole, DILS was inversely related to soil-substrate OMC. Cross-correlational analysis revealed significant positive association among most of the variables tested. The findings of this study should serve as baseline information for the development of effective environmental management strategies for malaria larval-vector control.

  12. Modelling Rift Valley fever (RVF) disease vector habitats using active and passive remote sensing systems

    Science.gov (United States)

    Ambrosia, Vincent G.; Linthicum, K. G.; Bailey, C. L.; Sebesta, P.

    1989-01-01

    The NASA Ames Ecosystem Science and Technology Branch and the U.S. Army Medical Research Institute of Infectious Diseases are conducting research to detect Rift Valley fever (RVF) vector habitats in eastern Africa using active and passive remote-sensing. The normalized difference vegetation index (NDVI) calculated from Landsat TM and SPOT data is used to characterize the vegetation common to the Aedes mosquito. Relationships have been found between the highest NDVI and the 'dambo' habitat areas near Riuru, Kenya on both wet and dry data. High NDVI values, when combined with the vegetation classifications, are clearly related to the areas of vector habitats. SAR data have been proposed for use during the rainy season when optical systems are of minimal use and the short frequency and duration of the optimum RVF mosquito habitat conditions necessitate rapid evaluation of the vegetation/moisture conditions; only then can disease potential be stemmed and eradication efforts initiated.

  13. High frame-rate blood vector velocity imaging using plane waves: simulations and preliminary experiments

    DEFF Research Database (Denmark)

    Udesen, J.; Gran, F.; Hansen, K.L.

    2008-01-01

    Conventional ultrasound methods for acquiring color images of blood velocity are limited by a relatively low frame-rate and are restricted to give velocity estimates along the ultrasound beam direction only. To circumvent these limitations, the method presented in this paper uses 3 techniques: 1...... carotid artery of a healthy male was scanned with a scan sequence that satisfies the limits set by the Food and Drug Administration. Vector velocity images were obtained with a frame-rate of 100 Hz where 40 speckle images are used for each vector velocity image. It was found that the blood flow...... approximately followed the vessel wall, and that maximum velocity was approximately 1 m/s, which is a normal value for a healthy person. To further evaluate the method, the test person was scanned with magnetic resonance (MR) angiography. The volume flow derived from the MR scanning was compared with that from...

  14. Recovering Photospheric Velocities from Vector Magnetograms by using a Three-Dimensional, Fully Magnetohydrodynamic (MHD) Model

    Science.gov (United States)

    Wang, A. H.; Wu, S. T.; Liu, Yang; Hathaway, D.

    2008-01-01

    We introduce a numerical simulation method for recovering the photospheric velocity field from the vector magnetograms. The traditional method is local correlation tracking (LCT) which is based on measuring the relative displacements of features in blocks of pixels between successive white-light images or magnetograms. Within this method, there are a variety of implementations. One of recently developed implementations is induction local correlation tracking (ILCT) as described by Welsch et al. (2004). They employ the normal component of magnetic induction equation as a constraint to assure consistent solutions. Our numerical method uses the fully three-dimensional MHD equations to recover the photospheric velocity field with individual vector magnetograms. We compare our method to the ILCT method using NOAA AR8210 as an example. The differences and similarities are discussed in detail.

  15. Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous-capillary permeability pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2014-01-01

    Full Text Available Following an application from Omikron Italia S.r.l., submitted pursuant to Article 13.5 of Regulation (EC No 1924/2006 via the Competent Authority of Italy, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous-capillary permeability. The food that is a subject of the health claim, a combination of diosmin, troxerutin and hesperidin, is sufficiently characterised. The claimed effect, maintenance of normal venous-capillary permeability, is a beneficial physiological effect. No human intervention studies from which conclusions could be drawn for the scientific substantiation of the claim were provided by the applicant. The Panel concludes that a cause and effect relationship has not been established between the consumption of a combination of diosmin, troxerutin and hesperidin and the maintenance of normal venous-capillary permeability.

  16. Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous tone pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2014-01-01

    Full Text Available Following an application from Omikron Italia S.r.l., submitted pursuant to Article 13.5 of Regulation (EC No 1924/2006 via the Competent Authority of Italy, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous tone. The food that is a subject of the health claim, a combination of diosmin, troxerutin and hesperidin, is sufficiently characterised. The claimed effect, maintenance of normal venous tone, is a beneficial physiological effect. No human intervention studies from which conclusions could be drawn for the scientific substantiation of the claim were provided by the applicant. The Panel concludes that a cause and effect relationship has not been established between the consumption of a combination of diosmin, troxerutin and hesperidin and the maintenance of normal venous tone.

  17. Relations between the IR-UV-X-ray Continuum and Emission Lines for a Large Composite Sample of Narrow Line and Normal Seyfert i Galaxies

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    We report on our research on the UV, optical line parameters and the infrared through UV to soft X-ray continuum parameters for a composite sample of narrow line and normal Seyfert 1 galaxies. The strong correlations among the line width of Hβ, optical line strength of Fe II and the soft X-ray slope are confirmed. We found no correlations between the UV line parameters, the equivalent widths of Lya and CIV and their ratio on one hand and the optical line parameters on the other. The UV and X-ray luminosities strongly correlate with the line widths of Hβand the Fe II/Hβ ratio. No significant correlation is found between the infrared-soft X-ray continuum slope αix and the line width of Hβ.

  18. [Noninvasive determination of pressure relations of intracranial and intracochlear fluid spaces during the glycerol test in normal probands and patients with Menière's disease].

    Science.gov (United States)

    Gosepath, K; Maurer, J; Thews, O; Mann, W

    1996-07-01

    The cochlear aqueduct is a route for direct pressure transfer between intracranial and intracochlear fluids. In patients with Menière's disease, intracochlear pressure is presumably disturbed. The "Tympanic Membrane Displacement Analyser (TDA)" is a new system which provides a useful noninvasive method of detecting intracranial and intracochlear pressure changes. In this study TDA measurements in combination with a glycerol test were performed in nine patients with Menière's disease and in seven normal persons. Before ingestion of glycerol, no significant difference in pressure was found between the two groups. After ingestion of glycerol a temporary decrease in intracochlear pressure was detected in both groups without any significant difference between the two groups. These results show that the combination of glycerol testing and TDA measurements does not seem to be helpful for the differential diagnosis of Menière's disease.

  19. Targeting of breast metastases using a viral gene vector with tumour-selective transcription.

    LENUS (Irish Health Repository)

    Rajendran, Simon

    2012-01-31

    BACKGROUND: Adeno-associated virus (AAV) vectors have significant potential as gene delivery vectors for cancer gene therapy. However, broad AAV2 tissue tropism results in nonspecific gene expression. MATERIALS AND METHODS: We investigated use of the C-X-C chemokine receptor type 4 (CXCR4) promoter to restrict AAV expression to tumour cells, in subcutaneous MCF-7 xenograft mouse models of breast cancer and in patient samples, using bioluminescent imaging and flow cytometric analysis. RESULTS: Higher transgene expression levels were observed in subcutaneous MCF-7 tumours relative to normal tissue (muscle) using the CXCR4 promoter, unlike a ubiquitously expressing Cytomegalovirus promoter construct, with preferential AAVCXCR4 expression in epithelial tumour and CXCR4-positive cells. Transgene expression following intravenously administered AAVCXCR4 in a model of liver metastasis was detected specifically in livers of tumour bearing mice. Ex vivo analysis using patient samples also demonstrated higher AAVCXCR4 expression in tumour compared with normal liver tissue. CONCLUSION: This study demonstrates for the first time, the potential for systemic administration of AAV2 vector for tumour-selective gene therapy.

  20. Light Vector Mesons in the Nuclear Medium

    Energy Technology Data Exchange (ETDEWEB)

    Wood, Michael; Nasseripour, Rakhsha; Weygand, Dennis; Djalali, Chaden; Tur, Clarisse; Mosel, Ulrich; Muehlich, Pascal; Adams, Gary; Amaryan, Moscov; Amaryan, Moskov; Ambrozewicz, Pawel; Anghinolfi, Marco; Asryan, Gegham; Avagyan, Harutyun; Baghdasaryan, Hovhannes; Baillie, Nathan; Ball, James; Baltzell, Nathan; Barrow, Steve; Battaglieri, Marco; Bedlinskiy, Ivan; Bektasoglu, Mehmet; Bellis, Matthew; Benmouna, Nawal; Berman, Barry; Biselli, Angela; Blaszczyk, Lukasz; Bouchigny, Sylvain; Boyarinov, Sergey; Bradford, Robert; Branford, Derek; Briscoe, William; Brooks, William; Burkert, Volker; Butuceanu, Cornel; Calarco, John; Careccia, Sharon; Carman, Daniel; Carnahan, Bryan; Casey, Liam; Chen, Shifeng; Cheng, Lu; Cole, Philip; Collins, Patrick; Coltharp, Philip; Crabb, Donald; Crannell, Hall; Crede, Volker; Cummings, John; Dashyan, Natalya; De Vita, Raffaella; De Sanctis, Enzo; Degtiarenko, Pavel; Denizli, Haluk; Dennis, Lawrence; Deur, Alexandre; Dharmawardane, Kahanawita; Dickson, Richard; Dodge, Gail; Doughty, David; Dugger, Michael; Dytman, Steven; Dzyubak, Oleksandr; Egiyan, Hovanes; Egiyan, Kim; Elfassi, Lamiaa; Elouadrhiri, Latifa; Eugenio, Paul; Fedotov, Gleb; Feldman, Gerald; Feuerbach, Robert; Fradi, Ahmed; Funsten, Herbert; Garcon, Michel; Gavalian, Gagik; Gilfoyle, Gerard; Giovanetti, Kevin; Girod, Francois-Xavier; Goetz, John; Gordon, Christopher; Gothe, Ralf; Griffioen, Keith; Guidal, Michel; Guler, Nevzat; Guo, Lei; Gyurjyan, Vardan; Hadjidakis, Cynthia; Hafidi, Kawtar; Hakobyan, Hayk; Hakobyan, Rafael; Hanretty, Charles; Hardie, John; Hassall, Neil; Hersman, F.; Hicks, Kenneth; Hleiqawi, Ishaq; Holtrop, Maurik; Hyde, Charles; Ilieva, Yordanka; Ireland, David; Ishkhanov, Boris; Isupov, Evgeny; Ito, Mark; Jenkins, David; Jo, Hyon-Suk; Johnstone, John; Joo, Kyungseon; Juengst, Henry; Kalantarians, Narbe; Kellie, James; Khandaker, Mahbubul; Khetarpal, Puneet; Kim, Wooyoung; Klein, Andreas; Klein, Franz; Klimenko, Alexei; Kossov, Mikhail; Krahn, Zebulun; Kramer, Laird; Kubarovsky, Valery; Kuhn, Joachim; Kuhn, Sebastian; Kuleshov, Sergey; Lachniet, Jeff; Laget, Jean; Langheinrich, Jorn; Lawrence, David; Li, Ji; Livingston, Kenneth; Lu, Haiyun; MacCormick, Marion; Markov, Nikolai; Mattione, Paul; McAleer, Simeon; McKinnon, Bryan; McNabb, John; Mecking, Bernhard; Mehrabyan, Surik; Melone, Joseph; Mestayer, Mac; Meyer, Curtis; Mibe, Tsutomu; Mikhaylov, Konstantin; Minehart, Ralph; Mirazita, Marco; Miskimen, Rory; Mokeev, Viktor; Moriya, Kei; Morrow, Steven; Moteabbed, Maryam; Mueller, James; Munevar Espitia, Edwin; Mutchler, Gordon; Nadel-Turonski, Pawel; Niccolai, Silvia; Niculescu, Gabriel; Niculescu, Maria-Ioana; Niczyporuk, Bogdan; Niroula, Megh; Niyazov, Rustam; Nozar, Mina; Osipenko, Mikhail; Ostrovidov, Alexander; Park, Kijun; Pasyuk, Evgueni; Paterson, Craig; Pereira, Sergio; Pierce, Joshua; Pivnyuk, Nikolay; Pocanic, Dinko; Pogorelko, Oleg; Pozdnyakov, Sergey; Preedom, Barry; Price, John; Prok, Yelena; Protopopescu, Dan; Raue, Brian; Riccardi, Gregory; Ricco, Giovanni; Ripani, Marco; Ritchie, Barry; Ronchetti, Federico; Rosner, Guenther; Rossi, Patrizia; Sabatie, Franck; Salamanca, Julian; Salgado, Carlos; Santoro, Joseph; Sapunenko, Vladimir; Schumacher, Reinhard; Serov, Vladimir; Sharabian, Youri; Sharov, Dmitri; Shvedunov, Nikolay; Smith, Elton; Smith, Lee; Sober, Daniel; Sokhan, Daria; Stavinsky, Aleksey; Stepanyan, Stepan; Stepanyan, Samuel; Stokes, Burnham; Stoler, Paul; Strakovski, Igor; Strauch, Steffen; Taiuti, Mauro; Tedeschi, David; Tkabladze, Avtandil; Tkachenko, Svyatoslav; Todor, Luminita; Ungaro, Maurizio; Vineyard, Michael; Vlassov, Alexander; Watts, Daniel; Weinstein, Lawrence; Williams, Michael; Wolin, Elliott; Yegneswaran, Amrit; Zana, Lorenzo; Zhang, Bin; Zhang, Jixie; Zhao, Bo; Zhao, Zhiwen

    2008-07-01

    The light vector mesons ($\\rho$, $\\omega$, and $\\phi$) were produced in deuterium, carbon, titanium, and iron targets in a search for possible in-medium modifications to the properties of the $\\rho$ meson at normal nuclear densities and zero temperature. The vector mesons were detected with the CEBAF Large Acceptance Spectrometer (CLAS) via their decays to $e^{+}e^{-}$. The rare leptonic decay was chosen to reduce final-state interactions. A combinatorial background was subtracted from the invariant mass spectra using a well-established event-mixing technique. The $\\rho$ meson mass spectrum was extracted after the $\\omega$ and $\\phi$ signals were removed in a nearly model-independent way. Comparisons were made between the $\\rho$ mass spectra from the heavy targets ($A > 2$) with the mass spectrum extracted from the deuterium target. With respect to the $\\rho$-meson mass, we obtain a small shift compatible with zero. Also, we measure widths consistent with standard nuclear many-body eff

  1. Parathyroid hormone-related protein is not required for normal ductal or alveolar development in the post-natal mammary gland.

    Directory of Open Access Journals (Sweden)

    Kata Boras-Granic

    Full Text Available PTHrP is necessary for the formation of the embryonic mammary gland and, in its absence, the embryonic mammary bud fails to form the neonatal duct system. In addition, PTHrP is produced by the breast during lactation and contributes to the regulation of maternal calcium homeostasis during milk production. In this study, we examined the role of PTHrP during post-natal mammary development. Using a PTHrP-lacZ transgenic mouse, we surveyed the expression of PTHrP in the developing post-natal mouse mammary gland. We found that PTHrP expression is restricted to the basal cells of the gland during pubertal development and becomes expressed in milk secreting alveolar cells during pregnancy and lactation. Based on the previous findings that overexpression of PTHrP in cap and myoepithelial cells inhibited ductal elongation during puberty, we predicted that ablation of native PTHrP expression in the post-natal gland would result in accelerated ductal development. To address this hypothesis, we generated two conditional models of PTHrP-deficiency specifically targeted to the postnatal mammary gland. We used the MMTV-Cre transgene to ablate the floxed PTHrP gene in both luminal and myoepithelial cells and a tetracycline-regulated K14-tTA;tetO-Cre transgene to target PTHrP expression in just myoepithelial and cap cells. In both models of PTHrP ablation, we found that mammary development proceeds normally despite the absence of PTHrP. We conclude that PTHrP signaling is not required for normal ductal or alveolar development.

  2. Parathyroid hormone-related protein is not required for normal ductal or alveolar development in the post-natal mammary gland.

    Science.gov (United States)

    Boras-Granic, Kata; VanHouten, Joshua; Hiremath, Minoti; Wysolmerski, John

    2011-01-01

    PTHrP is necessary for the formation of the embryonic mammary gland and, in its absence, the embryonic mammary bud fails to form the neonatal duct system. In addition, PTHrP is produced by the breast during lactation and contributes to the regulation of maternal calcium homeostasis during milk production. In this study, we examined the role of PTHrP during post-natal mammary development. Using a PTHrP-lacZ transgenic mouse, we surveyed the expression of PTHrP in the developing post-natal mouse mammary gland. We found that PTHrP expression is restricted to the basal cells of the gland during pubertal development and becomes expressed in milk secreting alveolar cells during pregnancy and lactation. Based on the previous findings that overexpression of PTHrP in cap and myoepithelial cells inhibited ductal elongation during puberty, we predicted that ablation of native PTHrP expression in the post-natal gland would result in accelerated ductal development. To address this hypothesis, we generated two conditional models of PTHrP-deficiency specifically targeted to the postnatal mammary gland. We used the MMTV-Cre transgene to ablate the floxed PTHrP gene in both luminal and myoepithelial cells and a tetracycline-regulated K14-tTA;tetO-Cre transgene to target PTHrP expression in just myoepithelial and cap cells. In both models of PTHrP ablation, we found that mammary development proceeds normally despite the absence of PTHrP. We conclude that PTHrP signaling is not required for normal ductal or alveolar development.

  3. A General Representation Theorem for Integrated Vector Autoregressive Processes

    DEFF Research Database (Denmark)

    Franchi, Massimo

    We study the algebraic structure of an I(d) vector autoregressive process, where d is restricted to be an integer. This is useful to characterize its polynomial cointegrating relations and its moving average representation, that is to prove a version of the Granger representation theorem valid...... for I(d) vector autoregressive processes...

  4. Constructions of vector output Boolean functions with high generalized nonlinearity

    Institute of Scientific and Technical Information of China (English)

    KE Pin-hui; ZHANG Sheng-yuan

    2008-01-01

    Carlet et al. recently introduced generalized nonlinearity to measure the ability to resist the improved correlation attack of a vector output Boolean function. This article presents a construction of vector output Boolean functions with high generalized nonlinearity using the sample space. The relation between the resilient order and generalized nonlinearity is also discussed.

  5. Vector operations for modelling data-conversion procedures

    Energy Technology Data Exchange (ETDEWEB)

    Rivkin, M.N.

    1992-03-01

    This article presents a set of vector operations that permit effective modelling of operations from extended relational algebra for implementations of variable-construction procedures in data-conversion processors. Vector operations are classified, and test results are given for the ARIUS UP and other popular database management systems for PC`s. 10 refs., 5 figs.

  6. On the lifting and approximation theorem for nonsmooth vector fields

    CERN Document Server

    Bramanti, Marco; Pedroni, Marco

    2010-01-01

    We prove a version of Rothschild-Stein's theorem of lifting and approximation and some related results in the context of nonsmooth Hormander's vector fields for which the highest order commutators are only Holder continuous. The theory explicitly covers the case of one vector field having weight two while the others have weight one.

  7. Números, vectores y funciones

    OpenAIRE

    1992-01-01

    El texto Números, Vectores y Funciones que han elaborado los profesores Asociados Omar Evelio Ospina y Bernardo Acevedo, responden a esta necesidad con sobresalientes cualidades pedagógicas, entre las cuales se destacan el desarrollo detallado de los temas y la proliferación de ejercicios resueltos, lo cual genera un diálogo directo con el lector que puede así aprovechar totalmente su lectura. El material presentado es el fruto de un cuidadoso análisis de los autores, sobre las experiencias d...

  8. Vector polarimetry at MAMI

    Energy Technology Data Exchange (ETDEWEB)

    Nillius, Fabian; Aulenbacher, Kurt [Institut fuer Kernphysik, Johannes Gutenberg-Universitaet Mainz (Germany)

    2013-07-01

    Electron/photon tensor-correlation coefficients may allow to design a polarimeter that can measure all components of beam polarisation simultaneously (''vector polarimeter''). Besides its purpose as a beam diagnostic device this would also allow to test theoretical predictions for the correlation coefficients at energies between 1 and 3.5 MeV. As a first step we have set up a measurement of the helicity transfer to the photon as a function of energy which is based on the Compton absorption method. Apparative developments in order to measure photon emission asymmetries caused by transverse and longitudinal electron polarisation are presented.

  9. Vector-borne diseases

    DEFF Research Database (Denmark)

    More, Simon J.; Bicout, Dominique; Bøtner, Anette

    2017-01-01

    After a request from the Europea n Commission, EFSA’s Panel on Animal Health and Welfaresummarised the main characteristics of 36 vector-borne disease s (VBDs) in 36 web-based storymaps.The risk of introduction in the EU through movement of livestock or pets was assessed for eac h of the36 VBDs...... new information becomesavailable. Since this risk assessment was carried out for large regions in the EU for many VBD-agents,it should be considered as a first screening. If a more detailed risk assessment for a specificVBDiswished for on a national or subnational level, the EFSA...

  10. Relativistic Rotating Vector Model

    CERN Document Server

    Lyutikov, Maxim

    2016-01-01

    The direction of polarization produced by a moving source rotates with the respect to the rest frame. We show that this effect, induced by pulsar rotation, leads to an important correction to polarization swings within the framework of rotating vector model (RVM); this effect has been missed by previous works. We construct relativistic RVM taking into account finite heights of the emission region that lead to aberration, time-of-travel effects and relativistic rotation of polarization. Polarizations swings at different frequencies can be used, within the assumption of the radius-to-frequency mapping, to infer emission radii and geometry of pulsars.

  11. Vector potential photoelectron microscopy.

    Science.gov (United States)

    Browning, R

    2011-10-01

    A new class of electron microscope has been developed for the chemical microanalysis of a wide range of real world samples using photoelectron spectroscopy. Highly structured, three-dimensional samples, such as fiber mats and fracture surfaces can be imaged, as well as insulators and magnetic materials. The new microscope uses the vector potential field from a solenoid magnet as a spatial reference for imaging. A prototype instrument has demonstrated imaging of uncoated silk, magnetic steel wool, and micron-sized single strand tungsten wires.

  12. A Novel Approach to Asynchronous MVP Data Interpretation Based on Elliptical-Vectors

    Science.gov (United States)

    Kruglyakov, M.; Trofimov, I.; Korotaev, S.; Shneyer, V.; Popova, I.; Orekhova, D.; Scshors, Y.; Zhdanov, M. S.

    2014-12-01

    We suggest a novel approach to asynchronous magnetic-variation profiling (MVP) data interpretation. Standard method in MVP is based on the interpretation of the coefficients of linear relation between vertical and horizontal components of the measured magnetic field.From mathematical point of view this pair of linear coefficients is not a vector which leads to significant difficulties in asynchronous data interpretation. Our approach allows us to actually treat such a pair of complex numbers as a special vector called an ellipse-vector (EV). By choosing the particular definitions of complex length and direction, the basic relation of MVP can be considered as the dot product. This considerably simplifies the interpretation of asynchronous data. The EV is described by four real numbers: the values of major and minor semiaxes, the angular direction of the major semiaxis and the phase. The notation choice is motivated by historical reasons. It is important that different EV's components have different sensitivity with respect to the field sources and the local heterogeneities. Namely, the value of major semiaxis and the angular direction are mostly determined by the field source and the normal cross-section. On the other hand, the value of minor semiaxis and the phase are responsive to local heterogeneities. Since the EV is the general form of complex vector, the traditional Schmucker vectors can be explicitly expressed through its components.The proposed approach was successfully applied to interpretation the results of asynchronous measurements that had been obtained in the Arctic Ocean at the drift stations "North Pole" in 1962-1976.

  13. The Impact of Energy Substrates, Hormone Level and Subject-Related Factors on Physiologic Myocardial {sup 18}F-FDG Uptake in Normal Humans

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Juhye; Kong, Eunjung; Chun, Kyungah; Cho, Ihnho [Yeung-Nam Univ. Hoepital, Daegu (Korea, Republic of)

    2013-12-15

    In a whole-body {sup 18}F-FDG PET/CT, non-specific {sup 18}F-FDG uptake of the myocardium is a common finding and can be very variable, ranging from background activity to intense accumulation and inhomogeneity. We investigated the effect of energy substrates and plasma/serum hormones that may have an influence on myocardial {sup 18}F-FDG uptake. F-FDG PET/CT was performed on 100 normal volunteers from November 2007 to August 2008. Blood samples were taken just before {sup 18}F-FDG injection from all subjects. Myocardial {sup 18}F-FDG uptake was measured as the mean (SUVmean) and maximal (SUV{sub max}) standardized uptake value. The myocardium was delineated on the PET/CT image by a manual volume of interest (VOI).We analyzed the influence of age, sex, presence of diabetes, fasting duration, insulin, glucagon, fasting glucose, lactate, free fatty acid (FFA), epinephrine (EPi), norepinephrine (NEp), free triiodothyronine (T3), free thyroxine (T4), thyroid-stimulating hormone (TSH) and body mass index (BMI). Overall, 92 subjects (mean age 50.28±8.30, male 57) were enrolled. The average of myocardial SUVmean was 2.08 and of myocardial SUV{sub max} was 4.57, respectively and there was a strong linear correlation between SUVmean and SUV{sub max} (r =0.98). FFA and fasting duration showed significant negative correlation with myocardial {sup 18}F-FDG uptake, respectively (r =-0.40 in FFA; r =-0.41 in fasting duration). No significant relationships were observed between myocardial uptake and age, sex, presence of diabetics, insulin, glucagon, fasting glucose, lactate, EPi, NEp, free T3, free T4, TSH and BMI. Myocardial {sup 18}F-FDG uptake decreases with longer fasting duration and higher FFA level in normal humans. Modulating myocardial uptake could improve {sup 18}F-FDG PET/CT imaging for specific oncologic and cardiovascular indications.

  14. Normalization: A Preprocessing Stage

    OpenAIRE

    Patro, S. Gopal Krishna; Sahu, Kishore Kumar

    2015-01-01

    As we know that the normalization is a pre-processing stage of any type problem statement. Especially normalization takes important role in the field of soft computing, cloud computing etc. for manipulation of data like scale down or scale up the range of data before it becomes used for further stage. There are so many normalization techniques are there namely Min-Max normalization, Z-score normalization and Decimal scaling normalization. So by referring these normalization techniques we are ...

  15. The Effect of Normally Consumed Amounts of Sucrose or High Fructose Corn Syrup on Lipid Profiles, Body Composition and Related Parameters in Overweight/Obese Subjects

    Directory of Open Access Journals (Sweden)

    Joshua Lowndes

    2014-03-01

    Full Text Available The American Heart Association (AHA has advocated that women and men not consume more than 100 and 150 kcal/day, respectively, from added sugars. These levels are currently exceeded by over 90% of the adult population in the United States. Few data exist on longer-term metabolic effects when sucrose and High Fructose Corn Syrup (HFCS, the principal sources of added dietary sugars, are consumed at levels typical of the general population. Sixty five overweight and obese individuals were placed on a eucaloric (weight stable diet for 10-weeks, which incorporated sucrose- or HFCS-sweetened, low-fat milk at 10% or 20% of calories in a randomized, double-blinded study. All groups responded similarly (interaction p > 0.05. There was no change in body weight in any of the groups over the 10-week study, or in systolic or diastolic blood pressure. Likewise, there were no changes in total cholesterol, triglycerides, low-density lipoprotein (LDL, or apolipoprotein B (Apo B. We conclude that (1 when consumed as part of a eucaloric diet fructose—when given with glucose (as normally consumed does not promote weight gain or an atherogenic lipid profile even when consumed at two to four times the level recently recommended by the AHA. (2 There were no differences between HFCS and sucrose on these parameters.

  16. Amyloid deposition detected with florbetapir F 18 (18F-AV-45) is related to lower episodic memory performance in clinically normal older individuals

    Science.gov (United States)

    Sperling, Reisa A.; Johnson, Keith A.; Doraiswamy, P. Murali; Reiman, Eric M.; Fleisher, Adam S.; Sabbagh, Marwan; Sadowsky, Carl; Carpenter, Alan; Davis, Mat; Lu, Ming; Flitter, Matthew; Joshi, Abhinay; Clark, Christopher M.; Grundman, Michael; Mintun, Mark; Skovronsky, Daniel; Pontecorvo, Michael

    2012-01-01

    The objective of this study was to evaluate the relationship of amyloid burden, as assessed by florbetapir F 18 (18F-AV-45) amyloid PET, and cognition in healthy older control subjects (HC). Seventy-eight HC subjects were assessed with a brief cognitive test battery and PET imaging with florbetapir F 18. A standard uptake value ratio (SUVr) was computed for mean data from six cortical regions using a whole cerebellum reference region. Scans were also visually rated as amyloid positive (Aβ+) or amyloid negative (Aβ−) by three readers. Higher SUVr correlated with lower immediate memory (r=−0.33; p=0.003) and delayed recall scores (r=−0.25; p=0.027). Performance on immediate recall was also lower in the visually rated Aβ+ compared to Aβ− HC (p=0.04), with a similar trend observed in delayed recall (p=0.06). These findings support the hypothesis that higher amyloid burden is associated with lower memory performance among clinically normal older subjects. Longitudinal follow-up is ongoing to determine whether florbetapir F 18 may also predict subsequent cognitive decline. PMID:22878163

  17. The effect of normally consumed amounts of sucrose or high fructose corn syrup on lipid profiles, body composition and related parameters in overweight/obese subjects.

    Science.gov (United States)

    Lowndes, Joshua; Sinnett, Stephanie; Pardo, Sabrina; Nguyen, Von T; Melanson, Kathleen J; Yu, Zhiping; Lowther, Britte E; Rippe, James M

    2014-01-01

    The American Heart Association (AHA) has advocated that women and men not consume more than 100 and 150 kcal/day, respectively, from added sugars. These levels are currently exceeded by over 90% of the adult population in the United States. Few data exist on longer-term metabolic effects when sucrose and High Fructose Corn Syrup (HFCS), the principal sources of added dietary sugars, are consumed at levels typical of the general population. Sixty five overweight and obese individuals were placed on a eucaloric (weight stable) diet for 10-weeks, which incorporated sucrose- or HFCS-sweetened, low-fat milk at 10% or 20% of calories in a randomized, double-blinded study. All groups responded similarly (interaction p > 0.05). There was no change in body weight in any of the groups over the 10-week study, or in systolic or diastolic blood pressure. Likewise, there were no changes in total cholesterol, triglycerides, low-density lipoprotein (LDL), or apolipoprotein B (Apo B). We conclude that (1) when consumed as part of a eucaloric diet fructose--when given with glucose (as normally consumed) does not promote weight gain or an atherogenic lipid profile even when consumed at two to four times the level recently recommended by the AHA. (2) There were no differences between HFCS and sucrose on these parameters.

  18. Expression of serine/threonine protein-kinases and related factors in normal monkey and human retinas: the mechanistic understanding of a CDK2 inhibitor induced retinal toxicity.

    Science.gov (United States)

    Saturno, Grazia; Pesenti, Manuela; Cavazzoli, Cristiano; Rossi, Anna; Giusti, Anna M; Gierke, Berthold; Pawlak, Michael; Venturi, Miro

    2007-12-01

    Protein-kinase inhibitors are among the most advanced compounds in development using the new drug discovery paradigm of developing small-molecule drugs against specific molecular targets in cancer. After treatment with a cyclin dependent kinase CDK2 inhibitor in monkey, histopathological analysis of the eye showed specific cellular damage in the photoreceptor layer. Since this CDK2 inhibitor showed activity also on other CDKs, in order to investigate the mechanism of toxicity of this compound, we isolated cones and rods from the retina of normal monkey and humans by Laser Capture Microdissection. Using Real-Time PCR we first measured the expression of cyclin dependent protein-kinases (CDK)1, 2, 4, 5, Glycogen synthase kinase 3beta (GSK3beta) and microtubule associated protein TAU. We additionally verified the presence of these proteins in monkey eye sections by immuno-histochemistry and immunofluorescence analysis and afterwards quantified GSK3beta, phospho-GSK3beta and TAU by Reverse Phase Protein Microarrays. With this work we demonstrate how complementary gene expression and protein-based technologies constitute a powerful tool for the understanding of the molecular mechanism of a CDK2 inhibitor induced toxicity. Moreover, this investigative approach is helpful to better understand and characterize the mechanism of species-specific toxicities and further support a rational, molecular mechanism-based safety assessment in humans.

  19. PMSVM: An Optimized Support Vector Machine Classification Algorithm Based on PCA and Multilevel Grid Search Methods

    Directory of Open Access Journals (Sweden)

    Yukai Yao

    2015-01-01

    Full Text Available We propose an optimized Support Vector Machine classifier, named PMSVM, in which System Normalization, PCA, and Multilevel Grid Search methods are comprehensively considered for data preprocessing and parameters optimization, respectively. The main goals of this study are to improve the classification efficiency and accuracy of SVM. Sensitivity, Specificity, Precision, and ROC curve, and so forth, are adopted to appraise the performances of PMSVM. Experimental results show that PMSVM has relatively better accuracy and remarkable higher efficiency compared with traditional SVM algorithms.

  20. Extended vector-tensor theories

    Science.gov (United States)

    Kimura, Rampei; Naruko, Atsushi; Yoshida, Daisuke

    2017-01-01

    Recently, several extensions of massive vector theory in curved space-time have been proposed in many literatures. In this paper, we consider the most general vector-tensor theories that contain up to two derivatives with respect to metric and vector field. By imposing a degeneracy condition of the Lagrangian in the context of ADM decomposition of space-time to eliminate an unwanted mode, we construct a new class of massive vector theories where five degrees of freedom can propagate, corresponding to three for massive vector modes and two for massless tensor modes. We find that the generalized Proca and the beyond generalized Proca theories up to the quartic Lagrangian, which should be included in this formulation, are degenerate theories even in curved space-time. Finally, introducing new metric and vector field transformations, we investigate the properties of thus obtained theories under such transformations.