WorldWideScience

Sample records for regulating body water

  1. CHIP regulates aquaporin-2 quality control and body water homeostasis

    DEFF Research Database (Denmark)

    Wu, Qi; Moeller, Hanne B.; Stevens, Donté A.

    2018-01-01

    The importance of the kidney distal convoluted tubule (DCT) and cortical collecting duct (CCD) is highlighted by various water and electrolyte disorders that arise when the unique transport properties of these segments are disturbed. Despite this critical role, little is known about which proteins...... by vasopressin; interacts with aquaporin-2 (AQP2), Hsp70, and Hsc70; and can directly ubiquitylate the water channel AQP2 in vitro. shRNA knockdown of CHIP in CCD cells increased AQP2 protein t1/2 and reduced AQP2 ubiquitylation, resulting in greater levels of AQP2 andphosphorylatedAQP2.CHIP knockdown increased...... the plasma membrane abundance of AQP2 in these cells. Compared with wild-type controls, CHIP knockout mice or novel CRISPR/Cas9 mice without CHIPE3 ligase activity had greater AQP2 abundance and altered renal water handling, with decreased water intake and urine volume, alongside higher urine osmolality. We...

  2. Cold-water acclimation does not modify whole-body fluid regulation during subsequent cold-water immersion.

    Science.gov (United States)

    Stocks, J M; Patterson, M J; Hyde, D E; Jenkins, A B; Mittleman, K D; Taylor, N A S

    2004-06-01

    We investigated the impact of cold-water acclimation on whole-body fluid regulation using tracer-dilution methods to differentiate between the intracellular and extracellular fluid compartments. Seven euhydrated males [age 24.7 (8.7) years, mass 74.4 (6.4) kg, height 176.8 (7.8) cm, sum of eight skinfolds 107.4 (20.4) mm; mean (SD)] participated in a 14-day cold-water acclimation protocol, with 60-min resting cold-water stress tests [CWST; 18.1 (0.1) degrees C] on days 1, 8 and 15, and 90-min resting cold-water immersions [18.4 (0.4) degrees C] on intervening days. Subjects were immersed to the 4th intercostal space. Intracellular and extracellular fluid compartments, and plasma protein, electrolyte and hormone concentrations were investigated. During the first CWST, the intracellular fluid (5.5%) and plasma volumes were reduced (6.1%), while the interstitial fluid volume was simultaneously expanded (5.4%). This pattern was replicated on days 8 and 15, but did not differ significantly among test days. Acclimation did not produce significant changes in the pre-immersion distribution of total body water, or changes in plasma osmolality, total protein, electrolyte, atrial natriuretic peptide or aldosterone concentrations. Furthermore, a 14-day cold-water acclimation regimen did not elicit significant changes in body-fluid distribution, urine production, or the concentrations of plasma protein, electrolytes or the fluid-regulatory hormones. While acclimation trends were not evident, we have confirmed that fluid from extravascular cells is displaced into the interstitium during acute cold-water immersion, both before and after cold acclimation.

  3. About Body Water

    Science.gov (United States)

    ... Video) Thyroid Disease Additional Content Medical News About Body Water By James L. Lewis, III, MD, Attending ... here for the Professional Version Water Balance About Body Water Dehydration Overhydration Water accounts for about one ...

  4. Gravity and body mass regulation

    Science.gov (United States)

    Warren, L. E.; Horwitz, B. A.; Fuller, C. A.

    1997-01-01

    The effects of altered gravity on body mass, food intake, energy expenditure, and body composition are examined. Metabolic adjustments are reviewed in maintenance of energy balance, neural regulation, and humoral regulation are discussed. Experiments with rats indicate that genetically obese rats respond differently to hypergravity than lean rats.

  5. Bursting bodies of water

    DEFF Research Database (Denmark)

    Rasmussen, Mattias Borg

    2014-01-01

    A silent threat is growing below receding glaciers: lakes are formed as the tongues of the glaciers draw back up the mountain, and huge and growing bodies of water beneath them are contained only be weak moraine walls.......A silent threat is growing below receding glaciers: lakes are formed as the tongues of the glaciers draw back up the mountain, and huge and growing bodies of water beneath them are contained only be weak moraine walls....

  6. Histamine and the regulation of body weight

    DEFF Research Database (Denmark)

    Jørgensen, Emilie A; Knigge, Ulrich; Warberg, Jørgen

    2007-01-01

    Energy intake and expenditure is regulated by a complex interplay between peripheral and central factors. An exhaustive list of peptides and neurotransmitters taking part in this complex regulation of body weight exists. Among these is histamine, which acts as a central neurotransmitter. In the p......Energy intake and expenditure is regulated by a complex interplay between peripheral and central factors. An exhaustive list of peptides and neurotransmitters taking part in this complex regulation of body weight exists. Among these is histamine, which acts as a central neurotransmitter...

  7. Drinking Water Contaminants -- Standards and Regulations

    Science.gov (United States)

    ... and Research Centers Contact Us Share Drinking Water Contaminants – Standards and Regulations EPA identifies contaminants to regulate ... other partners to implement these SDWA provisions. Regulated Contaminants National Primary Drinking Water Regulations (NPDWRs) - table of ...

  8. Normotension, hypertension and body fluid regulation

    DEFF Research Database (Denmark)

    Bie, Peter; Evans, R G

    2017-01-01

    The fraction of hypertensive patients with essential hypertension (EH) is decreasing as the knowledge of mechanisms of secondary hypertension increases, but in most new cases of hypertension the pathophysiology remains unknown. Separate neurocentric and renocentric concepts of aetiology have...... activity are elevated in about 50% of cases; (iii) in EH as in normal conditions, mediators other than arterial blood pressure are the major determinants of renal sodium excretion; (iv) chronic hypertension is always associated with a shift in the pressure-natriuresis curve, but this may...... prevailed without much interaction. In this regard, several questions regarding the relationships between body fluid and blood pressure regulation are pertinent. Are all forms of EH associated with sympathetic overdrive or a shift in the pressure-natriuresis curve? Is body fluid homoeostasis normally driven...

  9. Body water, extracellular water, body potassium, and exchangeable sodium in body builders using anabolic steroids

    International Nuclear Information System (INIS)

    Wang, J.; Colt, E.D.W.; Pierson, R.N. Jr.

    1986-01-01

    Nine competitive male body builders aged 21 to 34 who were determined to take anabolic steroids were studied before and 6 to 10 weeks after a training cycle which included steroid administration. A control group of nine subjects matched in age and duration of competitive career, but using only natural training methods were studied on a single occasion while in training. Total body potassium (TBK) by 40 K, total body water (TBW) by 3 H 2 O dilution, extracellular water (ECW) by 35 SO 4 dilution and zero time extrapolation, and exchangeable sodium by 24 Na dilution were measured before and after training. Intracellular water (ICW) was calculated from TBW - ECW. Initially steroid users had a greater skeletal muscle mass than control subjects, and obtained a further weight gain on steroids, all in skeletal muscle, based on parallel increases in TBK and ICW. Other body composition measurements did not change significantly. A single steroid user became ill taking steroids, decreased potassium by 5%, and increased extracellular water, changes which may represent the effects of hepatic dysfunction which occurred while on anabolic steroids

  10. Creating prototypes for cooling urban water bodies

    NARCIS (Netherlands)

    Cortesoao, Joao; Klok, E.J.; Lenzholzer, Sanda; Jacobs, C.M.J.; Kluck, J.

    2017-01-01

    Abstract When addressing urban heat problems, climate- conscious urban design has been assuming that urban water bodies such as canals, ditches or ponds cool down their surroundings. Recent research shows that this is not necessarily the case and that urban water bodies may actually have a warming e

  11. Regulation Development for Drinking Water Contaminants

    Science.gov (United States)

    To explain what process and information underlies regulations including how the Safe Drinking Water Act applies to regulation development i.e. how does the drinking water law translate into regulations.

  12. Radiation Regulation Bodies in South Africa

    International Nuclear Information System (INIS)

    Mavunda, R.D.

    2010-01-01

    Tthere are two types Regulatory Bodies in South Africa: department of Health - Radiation Control (DoH) and National Nuclear Regulator (NNR). The function DoH include of Promotion and maintenance of health within the framework of National health plan, Protection against injury or disease caused by technological devises, Protection against injury or disease caused by radiation, Promote safe and legal use of such products. The National Nuclear Regulator authorizes Nuclear Installation License, Nuclear Vessel License, Certificate of Registration and Certificate of Exemption. Some of the Electronic Products include licensing electro-medical products, Import or manufactured License conditions, Radiation workers, Report forms, Use and Radio-nuclides. Nuclear Authorization is the process of granting, by the National Nuclear Regulator, a written approval to applicants or / and operating organizations to perform nuclear related activities as detailed in the scope of the authorization. International Trade Administration Commission of South Africa (ITAC) issue license for import and export of all products including electronic X-Ray products and Radio-nuclides

  13. Effects of evaporative cooling on the regulation of body water and milk production in crossbred Holstein cattle in a tropical environment

    Science.gov (United States)

    Chaiyabutr, N.; Chanpongsang, S.; Suadsong, S.

    2008-09-01

    The aim of this study was to determine how evaporative cooling modifies body function with respect to water metabolism and other variables relevant to milk synthesis in crossbred cattle. The study was conducted on two groups of 0.875HF:0.125RS crossbred Holstein cattle (87.5%) housed in an open-sided barn with a tiled roof (non-cooled animals) and in a close-sided barn under an evaporative cooling system (cooled animals). The maximum ambient temperature and relative humidity for the non-cooled group were 33°C and 61%, with the corresponding values for the evaporatively cooled barn being 28°C and 84%, respectively. The temperature humidity index (THI) of under non-cooled conditions was higher ( P glucose and triglyceride of cooled animals were not significantly different compared with values for non-cooled animals. No differences were seen in plasma hormonal levels for triiodotyronine (T3) and insulin-like growth factor-1 (IGF-1), but plasma cortisol and thyroxine (T4) levels tended to be lower in non-cooled animals. This study suggests that low cooling temperature accompanied by high humidity influences a galactopoietic effect, in part through increases in ECF, blood volume and plasma volume in association with an increase in DMI, which partitions the distribution of nutrients to the mammary gland for milk synthesis. Cooled animals were unable to maintain high milk yield as lactation advances even though a high level of body fluids was maintained during long-term cooled exposure. The decline in milk yield, coinciding with a decrease in net energy for lactation as lactation advances, could be attributed to a local change within the mammary gland.

  14. Operational Management System for Regulated Water Systems

    Science.gov (United States)

    van Loenen, A.; van Dijk, M.; van Verseveld, W.; Berger, H.

    2012-04-01

    Most of the Dutch large rivers, canals and lakes are controlled by the Dutch water authorities. The main reasons concern safety, navigation and fresh water supply. Historically the separate water bodies have been controlled locally. For optimizating management of these water systems an integrated approach was required. Presented is a platform which integrates data from all control objects for monitoring and control purposes. The Operational Management System for Regulated Water Systems (IWP) is an implementation of Delft-FEWS which supports operational control of water systems and actively gives advice. One of the main characteristics of IWP is that is real-time collects, transforms and presents different types of data, which all add to the operational water management. Next to that, hydrodynamic models and intelligent decision support tools are added to support the water managers during their daily control activities. An important advantage of IWP is that it uses the Delft-FEWS framework, therefore processes like central data collection, transformations, data processing and presentation are simply configured. At all control locations the same information is readily available. The operational water management itself gains from this information, but it can also contribute to cost efficiency (no unnecessary pumping), better use of available storage and advise during (water polution) calamities.

  15. Bacteriological physicochemical quality of recreational water bodies ...

    African Journals Online (AJOL)

    tinsae

    logical quality, and there are no guidelines (standards) towards the safe use and quality control of recreational water. Under this circumstances, it is neither possible to know the gravity of the problem, nor simple to manage the possible health related risks that are associated with the use of recreational water bodies.

  16. Mushroom bodies regulate habit formation in Drosophila.

    Science.gov (United States)

    Brembs, Björn

    2009-08-25

    To make good decisions, we evaluate past choices to guide later decisions. In most situations, we have the opportunity to simultaneously learn about both the consequences of our choice (i.e., operantly) and the stimuli associated with correct or incorrect choices (i.e., classically). Interestingly, in many species, including humans, these learning processes occasionally lead to irrational decisions. An extreme case is the habitual drug user consistently administering the drug despite the negative consequences, but we all have experience with our own, less severe habits. The standard animal model employs a combination of operant and classical learning components to bring about habit formation in rodents. After extended training, these animals will press a lever even if the outcome associated with lever-pressing is no longer desired. In this study, experiments with wild-type and transgenic flies revealed that a prominent insect neuropil, the mushroom bodies (MBs), regulates habit formation in flies by inhibiting the operant learning system when a predictive stimulus is present. This inhibition enables generalization of the classical memory and prevents premature habit formation. Extended training in wild-type flies produced a phenocopy of MB-impaired flies, such that generalization was abolished and goal-directed actions were transformed into habitual responses.

  17. New storm water regulations impact industry

    International Nuclear Information System (INIS)

    Gemar, C.

    1991-01-01

    In November 1990, new Environmental Protection Agency (EPA) regulations aimed at governing the discharge of storm water from industrial facilities became effective. Because some industrial runoff contains toxics and other pollutants, the EPA considers storm water a major source of water contamination. The new regulations will have a profound impact on the National Pollutant Discharge Elimination System (NPDES) permit requirements for industry. This paper summarizes the new storm water regulations, focusing on the requirements for industrial facilities. It also presents suggestions for compliance

  18. Regulating Readers' Bodies: A Discourse Analysis of Teachers' Body Talk

    Science.gov (United States)

    Lester, Jessica Nina; Gabriel, Rachael

    2017-01-01

    In this paper, we report findings from a discourse analysis study of reading instruction in eight primary/elementary school classrooms in the United States. Drawing upon discursive psychology, we specifically examined 96 hours of reading comprehension instruction, with a focus on how teachers talked about the body during the instruction and noted…

  19. Total body water and total body potassium in anorexia nervosa

    Energy Technology Data Exchange (ETDEWEB)

    Dempsey, D.T.; Crosby, L.O.; Lusk, E.; Oberlander, J.L.; Pertschuk, M.J.; Mullen, J.L.

    1984-08-01

    In the ill hospitalized patient with clinically relevant malnutrition, there is a measurable decrease in the ratio of the total body potassium to total body water (TBK/TBW) and a detectable increase in the ratio of total exchangeable sodium to total exchangeable potassium (Nae/Ke). To evaluate body composition analyses in anorexia nervosa patients with chronic uncomplicated semistarvation, TBK and TBW were measured by whole body K40 counting and deuterium oxide dilution in 10 females with stable anorexia nervosa and 10 age-matched female controls. The ratio of TBK/TBW was significantly (p less than 0.05) higher in anorexia nervosa patients than controls. The close inverse correlation found in published studies between TBK/TBW and Nae/Ke together with our results suggest that in anorexia nervosa, Nae/Ke may be low or normal. A decreased TBK/TBW is not a good indicator of malnutrition in the anorexia nervosa patient. The use of a decreased TBK/TBW ratio or an elevated Nae/Ke ratio as a definition of malnutrition may result in inappropriate nutritional management in the patient with severe nonstressed chronic semistarvation.

  20. Total body water and total body potassium in anorexia nervosa

    International Nuclear Information System (INIS)

    Dempsey, D.T.; Crosby, L.O.; Lusk, E.; Oberlander, J.L.; Pertschuk, M.J.; Mullen, J.L.

    1984-01-01

    In the ill hospitalized patient with clinically relevant malnutrition, there is a measurable decrease in the ratio of the total body potassium to total body water (TBK/TBW) and a detectable increase in the ratio of total exchangeable sodium to total exchangeable potassium (Nae/Ke). To evaluate body composition analyses in anorexia nervosa patients with chronic uncomplicated semistarvation, TBK and TBW were measured by whole body K40 counting and deuterium oxide dilution in 10 females with stable anorexia nervosa and 10 age-matched female controls. The ratio of TBK/TBW was significantly (p less than 0.05) higher in anorexia nervosa patients than controls. The close inverse correlation found in published studies between TBK/TBW and Nae/Ke together with our results suggest that in anorexia nervosa, Nae/Ke may be low or normal. A decreased TBK/TBW is not a good indicator of malnutrition in the anorexia nervosa patient. The use of a decreased TBK/TBW ratio or an elevated Nae/Ke ratio as a definition of malnutrition may result in inappropriate nutritional management in the patient with severe nonstressed chronic semistarvation

  1. Body Characteristics, Dietary Protein and Body Weight Regulation

    DEFF Research Database (Denmark)

    Ankarfeldt, Mikkel Zøllner; Ängquist, Lars; Stocks, Tanja

    2014-01-01

    between greater protein intake and weight gain. In both types of studies the results are based on average weight changes, and show considerable diversity in both directions. This study investigates whether the discrepancy in the evidence could be due to recruitment of overweight and obese individuals...... with greater body mass index and waist circumference were analyzed. Selecting subsets of large-scale observational cohort studies with similar characteristics as participants in clinical trials may reconcile the otherwise conflicting results....

  2. Regulating tritium in drinking water

    International Nuclear Information System (INIS)

    Fluke, R.

    1994-01-01

    This article incorporates an article by E. Koehl from an internal Ontario Hydro publication, and a letter from the Joint Committee of Health and Safety of the Royal Society of Canada and the Canadian Academy of Engineering, submitted to the Ontario Minister of the Environment and Energy. The Advisory Committee on Environmental Standards had recommended that the limit for tritium in Ontario drinking water be reduced from 40,000 to 100 Bq/L, with a further reduction to 20 in five years. Some facts and figures are adduced to show that the effect of tritium in drinking water in Ontario is negligible compared to the effect of background radiation. The risk from tritium to the people of Ontario is undetectably small, and the attempt to estimate this risk by linear extrapolation is extremely dubious. Regulation entails social and economic costs, and the government ought to ensure that the benefits exceed the costs. The costs translate into nothing less than wasted opportunity to save lives in other ways. 3 refs

  3. Brain nuclear receptors and body weight regulation

    Science.gov (United States)

    Neural pathways, especially those in the hypothalamus, integrate multiple nutritional, hormonal, and neural signals, resulting in the coordinated control of body weight balance and glucose homeostasis. Nuclear receptors (NRs) sense changing levels of nutrients and hormones, and therefore play essent...

  4. Cardiovascular regulation during body unweighting by lower body positive pressure.

    Science.gov (United States)

    Evans, Joyce M; Mohney, Lindsay; Wang, Siqi; Moore, Rachel K; Elayi, Samy-Claude; Stenger, Michael B; Moore, Fritz B; Knapp, Charles F

    2013-11-01

    We hypothesized that human cardiovascular responses to standing in reduced gravity environments, as on the Moon or Mars, could be modeled using a lower body positive pressure (LBPP) chamber. Heart rate, blood pressure, body segment fluid shifts, ECG, indexes of sympathetic, parasympathetic balance, and baroreflex control of the heart and periphery plus echocardiographic measures of cardiac function were recorded from seven men and seven women supine and standing at 100% (Earth), 40% (-Mars), and 20% (-Moon) bodyweights (BW). The fluid shifted from the chest was greater when standing at 100% BW than at 20% and 40% BW, while fluid pooled in the abdomen was similar at all BWs. Compared to moving from supine to standing at 100% BW, moving to 20% and 40% BW resulted in smaller decreases in stroke volume and pulse pressure, smaller increases in heart rate and smaller decreases in parasympathetic control of heart rate, baroreflex slope, numbers of blood pressure ramps, and much reduced indexes of sympathetic drive to the heart and periphery. However, peripheral vascular resistance, systolic pressure, and baroreflex effectiveness were elevated during 20% and 40% BW, compared to supine and standing at 100% BW. Standing at reduced bodyweight suppressed indexes of sympathetic control of heart rate and peripheral vasomotion. Regulatory responses indicated a combination of arterial and cardiopulmonary baroreflex control: mean heart rate, vasomotion, and baroreflex sensitivity appeared to be more under cardiopulmonary control while baroreflex effectiveness appeared to be driven more by the arterial baroreflex.

  5. Protection of Urban Water body Infrastructure - Policy Requirements

    Science.gov (United States)

    Neelakantan, T. R.; Ramakrishnan, K.

    2017-07-01

    Water body is an important infrastructure of urban landscape. Water bodies like tanks and ponds are constructed to harvest rainwater for local use. Such water bodies serve many environmental functions including flood and soil erosion control and are useful for irrigation, drinking water supply and groundwater recharge. A large number of water bodies recently have been lost due to anthropogenic activities and the remaining water bodies are under stress due to risk of degradation. There are many phases to solve or control the problem; starting from stopping the abuse, to restoration to monitoring and maintenance. In this situation, the existing urban and peri-urban water bodies are to be preserved and rehabilitated. In this study, policy requirements for the protection (preservation and rehabilitation) of water bodies are analyzed with special reference to Thanjavur city. Thanjavur city has many water bodies and moat around the Big-Temple and the palace, and stands as an evidence for water management in ancient days. These water bodies are to be protected and used properly for sustainable growth of the city. This paper envisages the following three: (a) need for evaluation of hydraulic and hydrologic properties of the water bodies for conserving rainwater and controlling flood water in the existing urban water bodies; (b) need for evaluation of potential of socio-environmental services by the water bodies, and (c) need for developing a relative importance index for protection of water bodies to prioritize the remedial actions.

  6. Future directions in water quality regulations

    International Nuclear Information System (INIS)

    Pontius, F.W.

    1997-01-01

    The Safe Drinking Water Act amendments of 1996 have imposed new requirements on the US Environmental Protection Agency (USEPA) to establish drinking water regulations. The regulatory process has been revised and now requires the use of sound science. Costs, benefits, and competing risks may also be considered. Current regulations for fluoride, volatile organic chemicals, total coliforms, surface water treatment, Phase 2 and Phase 5 synthetic organic and inorganic contaminants, and lead and copper remain basically unchanged. New deadlines are established for the regulation of arsenic, sulfate, radon, disinfectants and disinfection by-products, enhanced surface water treatment, and groundwater disinfection

  7. Renal renin secretion as regulator of body fluid homeostasis

    DEFF Research Database (Denmark)

    Damkjær, Mads; Isaksson, Gustaf L; Stubbe, Jane

    2013-01-01

    The renin-angiotensin system is essential for body fluid homeostasis and blood pressure regulation. This review focuses on the homeostatic regulation of the secretion of active renin in the kidney, primarily in humans. Under physiological conditions, renin secretion is determined mainly by sodium...

  8. Cardiovascular regulation during water immersion.

    Science.gov (United States)

    Park, K S; Choi, J K; Park, Y S

    1999-11-01

    Head-out water immersion at thermoneutral temperature (34-35 degrees C) increases cardiac output for a given O2 consumption, leading to a relative hyperperfusion of peripheral tissues. To determine if subjects immersed in water at a colder temperature show similar responses and to explore the significance of the hyperperfusion, cardiovascular functions were investigated (impedance cardiography) on 10 men at rest and while performing exercise on a leg cycle ergometer (delta M = approximately 95 W.m-2) in air and in water at 34.5 degrees C and 30 degrees C, respectively. In subjects resting in water, the cardiac output increased by approximately 50% compared to that in air, mainly due to a rise in stroke volume. The stroke volume change tended to be greater in 30 degrees C water than in 34.5 degrees C water, and this was due to a greater increase in cardiac preload, as indicated by a significantly greater left ventricular end-diastolic volume. Arterial systolic pressure rose slightly during water immersion. Arterial diastolic pressure remained unchanged in 34.5 degrees C water, but it rose in 30 degrees C water. The total peripheral resistance fell 37% in 34.5 degrees C water and 32% in 30 degrees C water. Both in air and in water, mild exercise increased the cardiac output, and this was mainly due to an increase in heart rate. Since, however, the stroke volume increased with water immersion, cardiac output at a given work load appeared to be significantly higher in water than in air. The arterial pressures did not decrease with water immersion, despite a marked reduction in total peripheral resistance. These results suggest that 1) during cold water immersion, peripheral vasoconstriction provides an additional increase in cardiac preload, leading to a further increase in the stroke volume compared to that of the thermoneutral water immersion, 2) the mechanism of cardiovascular adjustment during dynamic exercise is not changed by the persistent increase in cardiac

  9. Machine-learning methods in the classification of water bodies

    Directory of Open Access Journals (Sweden)

    Sołtysiak Marek

    2016-06-01

    Full Text Available Amphibian species have been considered as useful ecological indicators. They are used as indicators of environmental contamination, ecosystem health and habitat quality., Amphibian species are sensitive to changes in the aquatic environment and therefore, may form the basis for the classification of water bodies. Water bodies in which there are a large number of amphibian species are especially valuable even if they are located in urban areas. The automation of the classification process allows for a faster evaluation of the presence of amphibian species in the water bodies. Three machine-learning methods (artificial neural networks, decision trees and the k-nearest neighbours algorithm have been used to classify water bodies in Chorzów – one of 19 cities in the Upper Silesia Agglomeration. In this case, classification is a supervised data mining method consisting of several stages such as building the model, the testing phase and the prediction. Seven natural and anthropogenic features of water bodies (e.g. the type of water body, aquatic plants, the purpose of the water body (destination, position of the water body in relation to any possible buildings, condition of the water body, the degree of littering, the shore type and fishing activities have been taken into account in the classification. The data set used in this study involved information about 71 different water bodies and 9 amphibian species living in them. The results showed that the best average classification accuracy was obtained with the multilayer perceptron neural network.

  10. [Revision of the drinking water regulations].

    Science.gov (United States)

    Hauswirth, S

    2011-11-01

    The revision the Drinking Water Regulations will come into effect on 01.11.2011. Surveillance authorities and owners of drinking water supply systems had hoped for simplifications and reductions because of the new arrangements. According to the official statement for the revision the legislature intended to create more clarity, consider new scientific findings, to change regulations that have not been proved to close regulatory gaps, to deregulate and to increase the high quality standards. A detailed examination of the regulation text, however, raises doubts. The new classification of water supply systems requires different modalities of registration, water analyses and official observation, which will complicate the work of the authorities. In particular, the implementation of requirements of registration and examination for the owners of commercial and publicly-operated large hot-water systems in accordance with DVGW Worksheet W 551 requires more effort. According to the estimated 30 000 cases of legionellosis in Germany the need for a check of such systems for Legionella, however, is not called into question. Furthermore, the development of sampling plans and the monitoring of mobile water supply systems requires more work for the health authorities. © Georg Thieme Verlag KG Stuttgart · New York.

  11. Autonomous profiling device to monitor remote water bodies

    Digital Repository Service at National Institute of Oceanography (India)

    Madhan, R.; Dabholkar, N.A.; Navelkar, G.S.; Desa, E.; Afzulpurkar, S.; Mascarenhas, A.A.M.Q.; Prabhudesai, S.P.

    implications to human health, and requires frequent and effective monitoring, particularly during summer months (March–May) when water consumption is highest. These water bodies are frequently located in remote areas away from human habitation, making...

  12. [Leptin and the feedback regulation of body weight].

    Science.gov (United States)

    Wang, X; Ye, G; Sun, J

    1999-09-30

    Body weight may be controlled by a negative feedback loop. Recent studies have identified that the ob gene product, leptin, apparently and exclusively expressed in adipose tissue, is a part of the negative feedback loop. Leptin is proposed to act as an afferent signal in the negative feedback loop to hypothalamus that limiting food-intake, controlling energy homeostasis and regulating the mass of adipose tissue. The dificiency of or resistance to leptin causes severe obesity.

  13. European Communities (Drinking water) Regulations, 2000

    International Nuclear Information System (INIS)

    2000-12-01

    These Regulations were adopted as Statutory Instrument No. 439 of 2000 on 18 December 2000 and come in to operation on 1 January 2004. The regulations give effect to provisions of EU Council Directive 98/83/EC on the quality of water intended for human consumption.. They prescribe quality standards to be applied in relation to certain supplies of drinking water. S.I. 439 of 2000 stipulates that the radiation dose arising from one year's consumption of drinking water should not exceed 0.1 mSv. It further stipulates that the dose calculation should include contributions from all natural and artificial radionuclides with the exception of tritium, potassium-40, radon and radon decay products

  14. Regulation of Ketone Body Metabolism and the Role of PPARα

    Directory of Open Access Journals (Sweden)

    Maja Grabacka

    2016-12-01

    Full Text Available Ketogenesis and ketolysis are central metabolic processes activated during the response to fasting. Ketogenesis is regulated in multiple stages, and a nuclear receptor peroxisome proliferator activated receptor α (PPARα is one of the key transcription factors taking part in this regulation. PPARα is an important element in the metabolic network, where it participates in signaling driven by the main nutrient sensors, such as AMP-activated protein kinase (AMPK, PPARγ coactivator 1α (PGC-1α, and mammalian (mechanistic target of rapamycin (mTOR and induces hormonal mediators, such as fibroblast growth factor 21 (FGF21. This work describes the regulation of ketogenesis and ketolysis in normal and malignant cells and briefly summarizes the positive effects of ketone bodies in various neuropathologic conditions.

  15. Seasonal changes in total body water; body composition and water turnover in reindeer

    Directory of Open Access Journals (Sweden)

    Terje S. Larsen

    1985-05-01

    Full Text Available Total body water and water turnover were measured at different times throughout the year in 3 captive Norwegian reindeer, using a tritiated water dilution method (Holleman et al. 1982. Total body water (percent of body weight increased during late autumn and winter, from 59.1 ± 1.5 % in October to 72.5 ± 2.0 % in April. Using the equatation by Pace and Rathbun (1945 for predicting total body fat (% fat = 100 - % water/0.732, this increase in total body water indicates a concomitant reduction in body fat, from a maximum value of 18.9 ± 2.6 % (of body weight in October to a minimum of 0.9 ± 2.7 % in April. During summer, on the other hand, fat content increased at the expense of a reduced percentage of body water. Water turnover was low in winter (December - April, ranging between 30.8 ± 5.2and43.6 ± 13.5ml.d-'. kg-1, but increased nearly fourfold during summer (June-August with a maximum of 117.7 ± 5.9 ml.d-1. kg-1 in August. Positive correlations between water turnover and food intake and between water turnover and ambient temperature were found, the latter probably resulting from an incidental correlation between food intake and ambient temperature.Sesongmessige forandringer i totalt kroppsvann, kropps-sammensetning og vannomsetning hos reinsdyr.Abstract in Norwegian / Sammendrag: Totalt kroppsvann og vannomsetning av vann ble målt til forskjellige årstider i 3 norske reinsdyr ved hjelp av utvasking av tritiert vann (Holleman et al. 1982. Totalt kroppsvann (prosent av kroppsvekt økte utover høsten og vinteren, fra 59.1 ± 1.5 % i oktober til 72.5 ± 2.0 % i april. Ved hjelp av en ligning som er gitt av Pace og Rathbun (1945 for beregning av totalt kroppsfett (% fett = 100 - % vann/0.732, fant en at denne økningen i vanninnhold tilsvarte en samtidig reduksjon i fettinnhold, fra en maksimums-verdi på 18.9 ± 2.6 % av kroppsvekt i oktober til et minimum på 0.9 ± 2.7 % i april. Utover sommeren økte derimot innholdet av fett p

  16. Chemical regulation of body feather microbiota in a wild bird.

    Science.gov (United States)

    Jacob, Staffan; Sallé, Louis; Zinger, Lucie; Chaine, Alexis S; Ducamp, Christine; Boutault, Léa; Russell, Andrew F; Heeb, Philipp

    2018-04-01

    The microbiota has a broad range of impacts on host physiology and behaviour, pointing out the need to improve our comprehension of the drivers of host-microbiota composition. Of particular interest is whether the microbiota is acquired passively, or whether and to what extent hosts themselves shape the acquisition and maintenance of their microbiota. In birds, the uropygial gland produces oily secretions used to coat feathers that have been suggested to act as an antimicrobial defence mechanism regulating body feather microbiota. However, our comprehension of this process is still limited. In this study, we for the first time coupled high-throughput sequencing of the microbiota of both body feathers and the direct environment (i.e., the nest) in great tits with chemical analyses of the composition of uropygial gland secretions to examine whether host chemicals have either specific effects on some bacteria or nonspecific broad-spectrum effects on the body feather microbiota. Using a network approach investigating the patterns of co-occurrence or co-exclusions between chemicals and bacteria within the body feather microbiota, we found no evidence for specific promicrobial or antimicrobial effects of uropygial gland chemicals. However, we found that one group of chemicals was negatively correlated to bacterial richness on body feathers, and a higher production of these chemicals was associated with a poorer body feather bacterial richness compared to the nest microbiota. Our study provides evidence that chemicals produced by the host might function as a nonspecific broad-spectrum antimicrobial defence mechanism limiting colonization and/or maintenance of bacteria on body feathers, providing new insight about the drivers of the host's microbiota composition in wild organisms. © 2018 John Wiley & Sons Ltd.

  17. 18 CFR 410.1 - Basin regulations-Water Code and Administrative Manual-Part III Water Quality Regulations.

    Science.gov (United States)

    2010-04-01

    ... Code and Administrative Manual-Part III Water Quality Regulations. 410.1 Section 410.1 Conservation of... CODE AND ADMINISTRATIVE MANUAL-PART III WATER QUALITY REGULATIONS § 410.1 Basin regulations—Water Code and Administrative Manual—Part III Water Quality Regulations. (a) The Water Code of the Delaware River...

  18. Ingested water equilibrates isotopically with the body water pool of a shorebird with unrivaled water fluxes

    NARCIS (Netherlands)

    Visser, G.H.; Dekinga, A; Achterkamp, B.; Piersma, T.

    We investigated the applicability of H-2 to measure the amount of body water (TBW) and water fluxes in relation to diet type and level of food intake in a mollusk-eating shorebird, the Red Knot (Calidris canutus). Six birds were exposed to eight experimental indoor conditions. Average fractional H-2

  19. Cadm2 regulates body weight and energy homeostasis in mice

    Directory of Open Access Journals (Sweden)

    Xin Yan

    2018-02-01

    Full Text Available Objective: Obesity is strongly linked to genes regulating neuronal signaling and function, implicating the central nervous system in the maintenance of body weight and energy metabolism. Genome-wide association studies identified significant associations between body mass index (BMI and multiple loci near Cell adhesion molecule2 (CADM2, which encodes a mediator of synaptic signaling enriched in the brain. Here we sought to further understand the role of Cadm2 in the pathogenesis of hyperglycemia and weight gain. Methods: We first analyzed Cadm2 expression in the brain of both human subjects and mouse models and subsequently characterized a loss-of-function mouse model of Cadm2 for alterations in glucose and energy homeostasis. Results: We show that the risk variant rs13078960 associates with increased CADM2 expression in the hypothalamus of human subjects. Increased Cadm2 expression in several brain regions of Lepob/ob mice was ameliorated after leptin treatment. Deletion of Cadm2 in obese mice (Cadm2/ob resulted in reduced adiposity, systemic glucose levels, and improved insulin sensitivity. Cadm2-deficient mice exhibited increased locomotor activity, energy expenditure rate, and core body temperature identifying Cadm2 as a potent regulator of systemic energy homeostasis. Conclusions: Together these data illustrate that reducing Cadm2 expression can reverse several traits associated with the metabolic syndrome including obesity, insulin resistance, and impaired glucose homeostasis. Keywords: Cadm2/SynCAM2, Energy homeostasis, Insulin sensitivity, Genome-wide association studies, Leptin signaling

  20. Daily Water Requirements when Wearing Body Armor

    National Research Council Canada - National Science Library

    Montain, Scott

    2000-01-01

    .... This report presents the results of model simulations predicting the individual daily water requirements under a broad range of energy expenditures and weather conditions when wearing battle dress...

  1. Regulation of food intake and body weight by recombinant proghrelin.

    Science.gov (United States)

    Zhang, Weizhen; Majumder, Arundhati; Wu, Xiaobin; Mulholland, Michael W

    2009-12-01

    Ghrelin is a 28-amino-acid hormone derived from the endoproteolytic processing of its prehormone proghrelin. Although ghrelin has been reported to regulate food intake and body weight, it is still unknown whether proghrelin exercises any biological function. Here we show that recombinant proghrelin alters food intake and energy metabolism in mice. After intraperitoneal administration of recombinant proghrelin (100 nmol/kg body wt), cumulative food intake was significantly increased at days 1, 2, and 3 (6 +/- 0.3, 13 +/- 0.5, and 20 +/- 0.8 g vs. 5 +/- 0.2, 10 +/- 0.2, and 16 +/- 0.3 g of the control mice receiving normal saline, respectively, n = 6, P light photo period in mice treated with proghrelin increased significantly relative to the control (2.1 +/- 0.04 vs. 1.3 +/- 0.2 g, n = 6, P dark photo period was observed between mice treated with proghrelin and vehicle (4.2 +/- 0.6 vs. 4.3 +/- 0.6 g, n = 6, P > 0.05). This is associated with a decrease in body weight (0.42 +/- 0.04 g) for mice treated with proghrelin, whereas control animals gained body weight (0.31 +/- 0.04 g). Mice treated with proghrelin demonstrate a significant decrease in respiratory quotient, indicating an increase in fat consumption. Recombinant proghrelin is functionally active with effects on food intake and energy metabolism.

  2. Regulation of Body Temperature by the Nervous System.

    Science.gov (United States)

    Tan, Chan Lek; Knight, Zachary A

    2018-04-04

    The regulation of body temperature is one of the most critical functions of the nervous system. Here we review our current understanding of thermoregulation in mammals. We outline the molecules and cells that measure body temperature in the periphery, the neural pathways that communicate this information to the brain, and the central circuits that coordinate the homeostatic response. We also discuss some of the key unresolved issues in this field, including the following: the role of temperature sensing in the brain, the molecular identity of the warm sensor, the central representation of the labeled line for cold, and the neural substrates of thermoregulatory behavior. We suggest that approaches for molecularly defined circuit analysis will provide new insight into these topics in the near future. Copyright © 2018 Elsevier Inc. All rights reserved.

  3. FSA Panel on Di etetic Products, Nutrition and Allergie s (NDA); Scientific Opinion on the substantiation of a health claim related to Vitis vinifera L. seeds extract and “helps to drain the body in case of water accumulation” pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Nutrilinks Sarl, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim...... related to Vitis vinifera L. seeds extract and “helps to drain the body in case of water accumulation”. The Panel considers that the food constituent which is the subject of the health claim is sufficiently characterised. The claimed effect proposed by the applicant is “helps to drain the body in case......” was a beneficial physiological effect in the context of “a normal venous circulation in the legs”. The applicant acknowledged that this claim referred to the same physiological function of the body as another health claim application on Vitis vinifera L. seeds extract and maintenance of normal venous blood flow...

  4. Bacteriological physicochemical quality of recreational water bodies ...

    African Journals Online (AJOL)

    tinsae

    importance of the safety of recreational waters, a cross-sectional study at Addis ... of chlorine-resistant germs, and pool staff and swimmers ... and have different water system except that of site 2. ... available in excreta of warm blooded animal.

  5. Indices of quality surface water bodies in the planning of water resources

    Directory of Open Access Journals (Sweden)

    Rodríguez-Miranda, Juan Pablo

    2016-12-01

    Full Text Available This paper considers a review of the literature major and significant methods of quality indices of water applied in surface water bodies, used and proposed for assessing the significance of parameters of water quality in the assessment of surface water currents and they are usually used in making decisions for intervention and strategic prevention measures for those responsible for the conservation and preservation of watersheds where these water bodies belong. An exploratory methodology was applied to realize the conceptualization of each water quality index. As a result, it is observed that there are several important methods for determining the water quality index applied in surface water bodies.

  6. Phytoremediation of water bodies contaminated with radioactive heavy metal

    International Nuclear Information System (INIS)

    Yan Zhen; Yuan Shichao; Ling Hui; Xie Shuibo

    2012-01-01

    The sources of the radioactive heavy metal in the water bodies were analyzed. The factors that affect phyto remediation of water contaminated with radioactive heavy metal were discussed. The plant species, mechanism and major technology of phyto remediation of water contaminated with radioactive heavy metal were particularly introduced. The prospective study was remarked. (authors)

  7. Distortion of calculated whole-body hematocrit during lower-body immersion in water.

    Science.gov (United States)

    Knight, D R; Santoro, T; Bondi, K R

    1986-11-01

    We found a difference between the venous hematocrits of immersed and nonimmersed arms during immersion of the lower body in cold water but not during a comparable exposure to warm water. Fourteen healthy men were exposed to three different experimental conditions: arm immersion, body immersion, and control. The men always sat upright while both upper extremities hung vertically at their sides. During arm immersion, one forearm was completely immersed for 30 min in either cold water (28 degrees C, n = 7) or warm water (38 degrees C, n = 7). This cold-warm water protocol was repeated on separate days for exposure to the remaining conditions of body immersion (immersion of 1 forearm and all tissues below the xiphoid process) and control (no immersion). Blood samples were simultaneously drawn from cannulated veins in both antecubital fossae. Hematocrit difference (Hct diff) was measured by subtracting the nonimmersed forearm's hematocrit (Hct dry) from the immersed forearm's hematocrit (Hct wet). Hct diff was approximately zero when the men were exposed to the control condition and body immersion in warm water. In the remaining conditions, Hct wet dropped below Hct dry (P less than 0.01, 3-way analysis of variance). The decrements of Hct diff showed there were differences between venous hematocrits in immersed and nonimmersed regions of the body, indicating that changes of the whole-body hematocrit cannot be calculated from a large-vessel hematocrit soon after immersing the lower body in cold water.

  8. Chronobiological methods of human body self-regulation reserve evaluation

    Directory of Open Access Journals (Sweden)

    Sergey N. Zaguskin

    2013-05-01

    Full Text Available Aims Chronodiagnostical methods for evaluating reserve and unfavourable responses of human cardiac function and under prolonged stress load. Materials and methods 24-h ECG R–R interval recording of Holter-monitoring ECG recording and 1-h IPI and RespI recordings of healthy young and elderly subjects, post- MI patients, subjects suffered from chronic cerebral ischemia leading to a cognitive decline, healthy subjects following post-stress load, as well as R– R intervals recordings of the AHA ECG database of heart failure and AF. Chronodiagnostics, using non-linear symbolic dynamics method and redundancy quotient of ECG PI, RespI and R– R intervals; differential temperature survey to evaluate cellular immunity; biocontrolled laser therapy. Results Self-regulation reserve reduction of oxygen transfer body systems and increase in unfavourable response probability under stress load are accompanied by the amplitude and fluctuation increase of redundancy quotient in the ECG IPI, RespI and R–R intervals, as well as increase of hierarchical desynchronosis with dominating sympathicotonia and vagotonia, decrease in cellular immunity, reduction in rate spectrum of the ECG IPI and R–R intervals. Conclusion Symbolic dynamics method provides distinction between age-related and abnormal changes in hierarchy of cardiac rhythms. The amplitude and fluctuation increase of redundancy quotient indicates the increase of control intensity with oxygen transfer body systems and predicts the reduction of self-regulation reserve in cardiac rhythms and unfavourable response probability.

  9. Hormonal Contraception, Body Water Balance and Thermoreregulation

    Science.gov (United States)

    1999-10-01

    were independent of changes in plasma volume. We have begun testing the impact of OC P and OC E+P on osmotic regulation of AVP during hypertonic saline infusion, but have completed only three subjects so have no comment at this point.

  10. Use of total body electrical conductivity (TOBEC) to determine total body water

    International Nuclear Information System (INIS)

    Cochran, W.; Wong, W.; Sheng, H.P.; Klein, P.; Klish, W.

    1986-01-01

    Total body electrical conductivity (TOBEC) has been introduced as a safe and rapid method to estimate body composition in infants and adults. Recently, a second generation instrument that operates in a scanning mode has been developed. A study was undertaken to calibrate this new instrument and to assess the feasibility of its use in estimating total body water. Six healthy adults, 3 males and 3 females, ranging in age from 25 to 57 years, and in weight from 43.3 to 104.7 kg were analyzed. Simultaneously, determinations of total body water were made by standard dilutional techniques using H 2 18 O. A baseline plasma sample was obtained and 60 mg 18 O/kg was given orally as H 2 18 O. Five hr later, a postdose plasma sample was obtained. The 18 O/ 16 O ratio in the plasma samples was determined as CO 2 by gas-isotope-ratio mass spectrometry and used to calculate the H 2 18 O volume of distribution. The total body water values ranged from 26.35 to 58.02 and represented 51 to 58% of body weight. There was good linear correlation between the total body water measurement and its phase average (TOBEC number) with a linear correlation coefficient of 0.998. The standard error of the estimate was 0.98. In addition to estimating fat and fat-free mass, the TOBEC method also estimates total body water with excellent correlation to physical dilutions methods

  11. Regulatory Body Safety Culture in Non-nuclear HROs: Lessons for Nuclear Regulators

    International Nuclear Information System (INIS)

    Fleming, M.; Bowers, K.

    2016-01-01

    Regulator safety culture is a relatively new area of investigation, even though deficiencies in regulatory oversight have been identified in a number of public inquiries (e.g., Piper Alpha, Deep Water Horizon). More recently the IAEA report into the Fukushima disaster specifically identified the need for regulatory bodies to have a positive safety culture. While there are clear parallels between duty holder safety culture and regulator safety culture there are also likely to be differences. To date they have been no published studies investigating regulator safety culture. In order to develop a framework to understand regulator safety culture we conducted a literature review and interviewed safety culture subject matter experts from a range of HRO domains (e.g., offshore oil and gas). There was general consensus among participants that regulatory safety culture was an important topic that was worthy of further investigation. That there was general agreement that regulatory safety culture was multi-dimensional and that some of the elements of existing safety culture models applied to regulator culture (e.g., learning and leadership). The participants also identified unique dimensions of regulator safety culture including commitment to high standards and ethics, transparency and perceived role of the regulator. In this paper we will present the results of the interviews and present a model of regulator safety culture. This model will be contrasted with models being used in the nuclear industry. Implications for assessing regulatory safety culture will be discussed. (author)

  12. Data considerations for regulation of water contaminants

    International Nuclear Information System (INIS)

    Schoeny, Rita; Haber, Lynne; Dourson, Michael

    2006-01-01

    There are several pieces of legislation based on human health assessment that set the framework for U.S. EPA's regulation of water contaminants, such as bromate. The Safe Drinking Water Act, for example, specifies that the best available science be used in support of regulation of drinking water contaminants, and highlights that regulations must provide protection to sensitive human populations. Recent EPA guidance, including the 2005 Cancer Guidelines, emphasize analyzing data, and using defaults only in the absence of adequate data. This represents a major shift from the former practice of invoking default methodologies or values unless it was judged that there were sufficient data to depart from them. The Guidelines further present a framework for assessing data in order to determine if a mode of action (MOA) can be established, based on a modification of the Bradford-Hill criteria for causality. A similar approach is used by the International Programme on Chemical Safety (IPCS). To illustrate the application of the framework for evaluating animal tumors, three case studies are considered here. In the first example (chloroform carcinogenicity), sufficient data exist to identify the MOA in animals, and the data are used to illustrate the evaluation of the plausibility of the animal MOA in humans, taking into account toxicokinetics and toxicodynamics. In this case, the MOA was judged to be relevant to humans, and was used to determine the approach for the cancer quantitation. In the second example (naphthalene inhalation carcinogenicity), the key question is whether the weight of evidence (WOE) is sufficient to establish the MOA in animals. Atrazine-induced mammary tumors form the final example, illustrating the reasoning used to determine that the tumor MOA in animals was not considered relevant to humans; atrazine is therefore considered not likely to be a human carcinogen

  13. 21 CFR 880.5560 - Temperature regulated water mattress.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Temperature regulated water mattress. 880.5560... Therapeutic Devices § 880.5560 Temperature regulated water mattress. (a) Identification. A temperature regulated water mattress is a device intended for medical purposes that consists of a mattress of suitable...

  14. Modeling regulated water utility investment incentives

    Science.gov (United States)

    Padula, S.; Harou, J. J.

    2014-12-01

    This work attempts to model the infrastructure investment choices of privatized water utilities subject to rate of return and price cap regulation. The goal is to understand how regulation influences water companies' investment decisions such as their desire to engage in transfers with neighbouring companies. We formulate a profit maximization capacity expansion model that finds the schedule of new supply, demand management and transfer schemes that maintain the annual supply-demand balance and maximize a companies' profit under the 2010-15 price control process in England. Regulatory incentives for costs savings are also represented in the model. These include: the CIS scheme for the capital expenditure (capex) and incentive allowance schemes for the operating expenditure (opex) . The profit-maximizing investment program (what to build, when and what size) is compared with the least cost program (social optimum). We apply this formulation to several water companies in South East England to model performance and sensitivity to water network particulars. Results show that if companies' are able to outperform the regulatory assumption on the cost of capital, a capital bias can be generated, due to the fact that the capital expenditure, contrarily to opex, can be remunerated through the companies' regulatory capital value (RCV). The occurrence of the 'capital bias' or its entity depends on the extent to which a company can finance its investments at a rate below the allowed cost of capital. The bias can be reduced by the regulatory penalties for underperformances on the capital expenditure (CIS scheme); Sensitivity analysis can be applied by varying the CIS penalty to see how and to which extent this impacts the capital bias effect. We show how regulatory changes could potentially be devised to partially remove the 'capital bias' effect. Solutions potentially include allowing for incentives on total expenditure rather than separately for capex and opex and allowing

  15. Connection of position sensing circuit of regulating body

    International Nuclear Information System (INIS)

    Janosek, B.

    1988-01-01

    The source of position pulses is connected to the evaluation unit to which is also connected a display which in turn is connected to a numerical selection unit connected via a power output to the action drive unit. A feedback member is connected between the evaluation unit and the numerical selection unit. Changes in the position of the regulating body produces voltage in the position sensor proportional to the actual value of this change. Voltage pulses are led via a measuring amplifier to the evaluation unit. After amplification the pulses are compared with the value on the numerical selection unit connected in the feedback branch to the measuring amplifier which evaluates differential values of pulses shown on the display in form of instantaneous and required values. The required value is selected via the numerical unit. (J.B.). 1 fig

  16. Can tritiated water-dilution space accurately predict total body water in chukar partridges

    International Nuclear Information System (INIS)

    Crum, B.G.; Williams, J.B.; Nagy, K.A.

    1985-01-01

    Total body water (TBW) volumes determined from the dilution space of injected tritiated water have consistently overestimated actual water volumes (determined by desiccation to constant mass) in reptiles and mammals, but results for birds are controversial. We investigated potential errors in both the dilution method and the desiccation method in an attempt to resolve this controversy. Tritiated water dilution yielded an accurate measurement of water mass in vitro. However, in vivo, this method yielded a 4.6% overestimate of the amount of water (3.1% of live body mass) in chukar partridges, apparently largely because of loss of tritium from body water to sites of dissociable hydrogens on body solids. An additional source of overestimation (approximately 2% of body mass) was loss of tritium to the solids in blood samples during distillation of blood to obtain pure water for tritium analysis. Measuring tritium activity in plasma samples avoided this problem but required measurement of, and correction for, the dry matter content in plasma. Desiccation to constant mass by lyophilization or oven-drying also overestimated the amount of water actually in the bodies of chukar partridges by 1.4% of body mass, because these values included water adsorbed onto the outside of feathers. When desiccating defeathered carcasses, oven-drying at 70 degrees C yielded TBW values identical to those obtained from lyophilization, but TBW was overestimated (0.5% of body mass) by drying at 100 degrees C due to loss of organic substances as well as water

  17. Water-body preferences of dominant calanoid copepod species in ...

    African Journals Online (AJOL)

    The distribution of five dominant calanoid copepods was related to different water masses in the Angola-Benguela Front system. Five water bodies were identified by principal component analysis, on the basis of abiotic parameters such as temperature, salinity, dissolved oxygen, phosphate, silicate, nitrate and nitrite.

  18. Importance of body-water circulation for body-heat dissipation in hot-humid climates: a distinctive body-water circulation in swamp buffaloes

    Directory of Open Access Journals (Sweden)

    S. Chanpongsang

    2010-02-01

    Full Text Available Thermo-regulation in swamp buffaloes has been investigated as an adaptive system to hot-humid climates, and several distinctive physiological responses were noted. When rectal temperature increased in hot conditions, blood volume, blood flow to the skin surface and skin temperature markedly increased in buffaloes relatively to cattle. On the other hand, the correlation between blood volume and plasma concentration of arginine vasopressin (AVP was compared between buffaloes and cattle under dehydration. Although plasma AVP in cattle increased immediately for reducing urine volume against a decrease in blood volume as well as the response observed in most animal species, the increase in plasma AVP was delayed in buffaloes, even after a large decrease in blood volume. In buffaloes, a marked increase in blood volume facilitated the dissipation of excess heat from the skin surface during wallowing. In addition, the change in plasma AVP observed in buffaloes was consistent with that of other animals living in habitats with the high availability of water. These results suggest that the thermo-regulatory system in buffaloes accelerates body-water circulation internally and externally. This system may be adaptive for heat dissipation in hot-humid climates, where an abundance of water is common.

  19. Whole body cooling by immersion in water at moderate temperatures.

    Science.gov (United States)

    Marino, F; Booth, J

    1998-06-01

    This study investigated the potential use of whole body cooling by water immersion for lowering body temperatures prior to endurance exercise. Rectal temperature (Tre), mean skin temperature (Tsk), oxygen consumption (VO2), and ventilation (VE) were measured in 7 male and 3 female subjects who were immersed in a water bath for up to 60 min. Initial water temperature was 28.8+/-1.5 degrees C and decreased to 23.8+/-1.1 degrees C by the end of immersion. Pre-immersion Tre of 37.34+/-0.36 degrees C was not altered by 60 min water immersion but decreased to 36.64+/-0.34 degrees C at 3 min post immersion (p immersion. Reductions in Tre and Tsk resulted in reduced body heat content (Hc) of approximately 545 kJ (p immersion. VO2 and VE increased from pre-immersion values of 0.34+/-0.08 L x min(-1) and 6.2+/-1.4 L x min(-1) to 0.54+/-0.09 L x min(-) and 11.5+/-5.4 L x min(-1) at the end of immersion, respectively. Heart rate remained unchanged throughout immersion. These results indicate that whole body immersion in moderately cold water temperatures is an effective cooling maneuver for lowering body temperatures and body Hc in the absence of severe physiological responses generally associated with sudden cold stress.

  20. Keratinophilic fungi in various types of water bodies

    Directory of Open Access Journals (Sweden)

    Bazyli Czeczuga

    2014-08-01

    Full Text Available The keratinophilic fungi in various types of water bodies (slough. pond. beach pool. two lakes and two rivers were studied. Samples of water were collected every other month for bydrochemical analysis and once a month (1989-1990 in order to determine the fungus content. Human hair, snippings of finger-nails, chips of hoofs, feathers and snake exuviae were used as bait. Twenty-five species of keratinophilic fungi were found in various types of water bodies. Hyphochytrium catenoides, Aphanomyces stellatus, Leptolegniella caudala and Achlya oligacantha represent new records as koratinophilic fungi.

  1. A General Water Resources Regulation Software System in China

    Science.gov (United States)

    LEI, X.

    2017-12-01

    To avoid iterative development of core modules in water resource normal regulation and emergency regulation and improve the capability of maintenance and optimization upgrading of regulation models and business logics, a general water resources regulation software framework was developed based on the collection and analysis of common demands for water resources regulation and emergency management. It can provide a customizable, secondary developed and extensible software framework for the three-level platform "MWR-Basin-Province". Meanwhile, this general software system can realize business collaboration and information sharing of water resources regulation schemes among the three-level platforms, so as to improve the decision-making ability of national water resources regulation. There are four main modules involved in the general software system: 1) A complete set of general water resources regulation modules allows secondary developer to custom-develop water resources regulation decision-making systems; 2) A complete set of model base and model computing software released in the form of Cloud services; 3) A complete set of tools to build the concept map and model system of basin water resources regulation, as well as a model management system to calibrate and configure model parameters; 4) A database which satisfies business functions and functional requirements of general water resources regulation software can finally provide technical support for building basin or regional water resources regulation models.

  2. Providing Longitudinal Connection In Case Of Cross Sluicing On Water Bodies In Banat Hydrographic Area

    Directory of Open Access Journals (Sweden)

    Hoancă Diana

    2014-10-01

    Full Text Available On Banat Hydrographic Area level, there are a series of works which put hydrological pressures on bodies of water: accumulations, damming, water diversions, regulations, shore protection, etc. These works were created in order to ensure water demand, defend against floods, regulate discharges, and combat humidity excess. Speaking justly, they have an important socioeconomic role. Among the negative effects of longitudinal connection interruption of water bodies we can mention, the risk of not achieving the positive ecological potential of water bodies in accordance with the Water Framework Directive, the reduction of the aquatic biodiversity, the reduction or even extinction of certain aquatic species and the alteration of the flow process. Because the negative effects of the hydromorphological alterations, especially those due to the interruption of the longitudinal connection, have a significant impact on the aquatic biodiversity. At Banat Hydrographic Area level, a series of measures, have been identified for the rehabilitation of the affected water courses: the removal of the hydrotechnical constructions from the water body if they have lost their functional features, building of passages for the migration of the ichthyofauna, reconnecting of the affluents and the disconnected arms as well as other measures intended to bring things back to their natural state. The implementation of these measures is made according to the importance and the extent of their positive impact as opposed to the negative effect that might occur as a consequence of their application. Analyzing the measures aforementioned and taking into consideration the characteristics of the hydromorphological pressures on water bodies in Banat Hydrographic Area, a number of measures regarding control are supplied in this paper.

  3. Normotension, hypertension and body fluid regulation: brain and kidney.

    Science.gov (United States)

    Bie, P; Evans, R G

    2017-01-01

    The fraction of hypertensive patients with essential hypertension (EH) is decreasing as the knowledge of mechanisms of secondary hypertension increases, but in most new cases of hypertension the pathophysiology remains unknown. Separate neurocentric and renocentric concepts of aetiology have prevailed without much interaction. In this regard, several questions regarding the relationships between body fluid and blood pressure regulation are pertinent. Are all forms of EH associated with sympathetic overdrive or a shift in the pressure-natriuresis curve? Is body fluid homoeostasis normally driven by the influence of arterial blood pressure directly on the kidney? Does plasma renin activity, driven by renal nerve activity and renal arterial pressure, provide a key to stratification of EH? Our review indicates that (i) a narrow definition of EH is useful; (ii) in EH, indices of cardiovascular sympathetic activity are elevated in about 50% of cases; (iii) in EH as in normal conditions, mediators other than arterial blood pressure are the major determinants of renal sodium excretion; (iv) chronic hypertension is always associated with a shift in the pressure-natriuresis curve, but this may be an epiphenomenon; (v) plasma renin levels are useful in the analysis of EH only after metabolic standardization and then determination of the renin function line (plasma renin as a function of sodium intake); and (vi) angiotensin II-mediated hypertension is not a model of EH. Recent studies of baroreceptors and renal nerves as well as sodium intake and renin secretion help bridge the gap between the neurocentric and renocentric concepts. © 2016 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

  4. Considering an Affect Regulation Framework for Examining the Association Between Body Dissatisfaction and Positive Body Image in Black Older Adolescent Females: Does Body Mass Index Matter?

    Science.gov (United States)

    Butler-Ajibade, Phoebe; Robinson, Seronda A.

    2014-01-01

    The present study provided an initial evaluation of an affect regulation model describing the association between body dissatisfaction and two contemporary measures of positive body image among 247 Black college-bound older adolescent females. We further tested whether possessing a higher body mass index (BMI) would strengthen these associations. Self-reported height and weight were used to calculate BMI. Respondents also completed a culturally-sensitive figure rating scale along with assessments of body appreciation and body image flexibility. Results indicated a robust positive association between the two measures of positive body image; BMI was the strongest predictor of both body appreciation and body image flexibility with body size discrepancy (current minus ideal) contributing incremental variance to both models tested. Implications for improving our understanding of the association between positive and negative body image and bolstering positive body image to promote health-protective behaviors among Black young women at this developmental juncture are discussed. PMID:25079011

  5. Associations among eating regulation and body mass index, weight, and body fat in college students: the moderating role of gender.

    Science.gov (United States)

    Gropper, Sareen S; Arsiwalla, Dilbur D; Lord, Denali C; Huggins, Kevin W; Simmons, Karla P; Ulrich, Pamela V

    2014-04-01

    This study investigated associations between eating regulation behaviors and body mass index (BMI), weight, and percent body fat in male and female students over the first two years of college. Subjects included 328 college students (215 females and 113 males). Height and weight (via standard techniques), body composition (via bioelectrical impedance analysis), and eating regulation behaviors (using the Regulation of Eating Behavior Scale) were conducted two to three times during both the freshman and sophomore years. Significant associations between eating regulation and BMI, weight, and/or percent body fat were shown mostly in females. In females, higher BMI, weight, and/or percent body fat at the end of the second year of college were found in those with low levels of autonomous, intrinsic motivation, and identified regulation, and high levels of amotivation, while lower BMI, weight, and/or percent body fat were associated with high levels of autonomous, intrinsic motivation, and identified regulation, and low levels of amotivation. The findings that specific eating behaviors in females during the first two years of college influence BMI, weight, and/or percent body fat may be useful for inclusion in university programs focused on college student health to help decrease the risk of obesity and disordered eating/eating disorders in female college students. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Impact of highway construction on water bodies: a geospatial assessment.

    Science.gov (United States)

    Vijay, Ritesh; Kushwaha, Vikash K; Mardikar, Trupti; Labhasetwar, P K

    2017-08-01

    India has witnessed a massive infrastructure boom in the past few years. One of such projects is National Highway-7 (NH-7), a North-South highway connecting Kanyakumari, Tamil Nadu, to Varanasi, Uttar Pradesh, traversing many water bodies. The present study aims to assess the pre- and post-construction impact due to existing, new and widened NH-7 on the physical status of the water bodies, using remote sensing techniques. Satellite images spanning 22 years were procured and analysed for change detection in land use and land cover within the waterbodies. The study indicates that construction activities have led to transformation within the water bodies regarding reduction in area and inter-changing of land use and land cover classes, in turn leading to siltation and reduction of recharge.

  7. Water and the thermal evolution of carbonaceous chondrite parent bodies

    International Nuclear Information System (INIS)

    Grimm, R.E.; Mcsween, H.Y. Jr.

    1989-01-01

    Two hypotheses are proposed for the aqueous alteration of carbonaceous chondrites within their parent bodies, in which respectively the alteration occurs (1) throughout the parent body interior, or (2) in a postaccretional surface regolith; both models assume an initially homogeneous mixture of ice and rock that is heated through the decay of Al-26. Water is seen to exert a powerful influence on chondrite evolution through its role of thermal buffer, permitting substitution of a low temperature aqueous alteration for high temperature recrystallization. It is quantitatively demonstrated that liquid water may be introduced by either hydrothermal circulation, vapor diffusion from below, or venting due to fracture. 104 refs

  8. Dynamic regulation and dysregulation of the water channel aquaporin-2: a common cause of and promising therapeutic target for water balance disorders.

    Science.gov (United States)

    Noda, Yumi

    2014-08-01

    The human body is two-thirds water. The ability of ensuring the proper amount of water inside the body is essential for the survival of mammals. The key event for maintenance of body water balance is water reabsorption in the kidney collecting ducts, which is regulated by aquaporin-2 (AQP2). AQP2 is a channel that is exclusively selective for water molecules and never allows permeation of ions or other small molecules. Under normal conditions, AQP2 is restricted within the cytoplasm of the collecting duct cells. However, when the body is dehydrated and needs to retain water, AQP2 relocates to the apical membrane, allowing water reabsorption from the urinary tubule into the cell. Its impairments result in various water balance disorders including diabetes insipidus, which is a disease characterized by a massive loss of water through the kidney, leading to severe dehydration in the body. Dysregulation of AQP2 is also a common cause of water retention and hyponatremia that exacerbate the prognosis of congestive heart failure and hepatic cirrhosis. Many studies have uncovered the regulation mechanisms of AQP2 at the single-molecule level, the whole-body level, and the clinical level. In clinical practice, urinary AQP2 is a useful marker for body water balance (hydration status). Moreover, AQP2 is now attracting considerable attention as a potential therapeutic target for water balance disorders which commonly occur in many diseases.

  9. Water entry of cylindrical bodies with various aspect ratios

    Science.gov (United States)

    Kim, Nayoung; Park, Hyungmin

    2017-11-01

    We experimentally investigate the water entry of cylindrical bodies with different aspect ratio (1.0-8.0), focusing on the deformation of free surface and resulting phenomena over and under the surface. The experiment is performed using a high-speed imaging (upto 10000 fps) and PIV. The head and tail of bodies are hemispherical and the nose part is additionally roughened with a sandpaper to see the effect of roughness as well. The release height is also adjusted to change the impact velocity at the free surface (Reynolds number is order of 105). For smooth surface (without cavity formation), a thin liquid film rises up the body after impacting, gathers at the pole and forms a jet over the free surfaces. The jet is created in the form of a thick and thin jet. The thin jet is produced by a water film riding up the surface of an object, and a thick jet is produced by rising water from underwater as the object sinks. However, as the aspect ratio increases, the liquid film does not fully ride up the body and cannot close, so there is an empty space below the free surface. With roughness (with cavity), the liquid film is detached from the body and splash/dome is formed above the free surface. The splash height and its collapsing time decrease with increasing the aspect ratio. Supported by Grants (MPSS-CG-2016-02, NRF-2017R1A4A1015523) of the Korea government.

  10. Voyageurs National Park: Water-level regulation and effects on water quality and aquatic biology

    Science.gov (United States)

    Christensen, Victoria G.; Maki, Ryan P.; LeDuc, Jaime F.

    2018-01-01

    Following dam installations in the remote Rainy Lake Basin during the early 1900s, water-level fluctuations were considered extreme (1914–1949) compared to more natural conditions. In 1949, the International Joint Commission (IJC), which sets rules governing dam operation on waters shared by the United States and Canada, established the first rule curves to regulate water levels on these waterbodies. However, rule curves established prior to 2000 were determined to be detrimental to the ecosystem. Therefore, the IJC implemented an order in 2000 to change rule curves and to restore a more natural water regime. After 2000, measured chlorophyll-a concentrations in the two most eutrophic water bodies decreased whereas concentrations in oligotrophic lakes did not show significant water-quality differences. Fish mercury data were inconclusive, due to the variation in water levels and fish mercury concentrations, but can be used by the IJC as part of a long term data set.

  11. Simulation of heavy metal contamination of fresh water bodies: toxic ...

    African Journals Online (AJOL)

    Michael Horsfall

    www.bioline.org.br/ja. Simulation of heavy metal contamination of fresh water bodies: toxic effects in the ... 96 hours (though sampling was done at the 48th hour). Biochemical markers of ... silver, while enhancing the bioavailability of mercury in Ceriodaphnia ..... Biochemical and molecular disorders of bilirubin metabolism.

  12. Oblique water entry of a three dimensional body

    Directory of Open Access Journals (Sweden)

    Scolan Yves-Marie

    2014-12-01

    Full Text Available The problem of the oblique water entry of a three dimensional body is considered. Wagner theory is the theoretical framework. Applications are discussed for an elliptic paraboloid entering an initially flat free surface. A dedicated experimental campaign yields a data base for comparisons. In the present analysis, pressure, force and dynamics of the wetted surface expansion are assessed.

  13. Water quality monitoring for high-priority water bodies in the Sonoran Desert network

    Science.gov (United States)

    Terry W. Sprouse; Robert M. Emanuel; Sara A. Strorrer

    2005-01-01

    This paper describes a network monitoring program for “high priority” water bodies in the Sonoran Desert Network of the National Park Service. Protocols were developed for monitoring selected waters for ten of the eleven parks in the Network. Park and network staff assisted in identifying potential locations of testing sites, local priorities, and how water quality...

  14. Innate recognition of water bodies in echolocating bats.

    Science.gov (United States)

    Greif, Stefan; Siemers, Björn M

    2010-11-02

    In the course of their lives, most animals must find different specific habitat and microhabitat types for survival and reproduction. Yet, in vertebrates, little is known about the sensory cues that mediate habitat recognition. In free flying bats the echolocation of insect-sized point targets is well understood, whereas how they recognize and classify spatially extended echo targets is currently unknown. In this study, we show how echolocating bats recognize ponds or other water bodies that are crucial for foraging, drinking and orientation. With wild bats of 15 different species (seven genera from three phylogenetically distant, large bat families), we found that bats perceived any extended, echo-acoustically smooth surface to be water, even in the presence of conflicting information from other sensory modalities. In addition, naive juvenile bats that had never before encountered a water body showed spontaneous drinking responses from smooth plates. This provides the first evidence for innate recognition of a habitat cue in a mammal.

  15. Neuroendocrine regulation of salt and water metabolism

    Directory of Open Access Journals (Sweden)

    S.M. McCann

    1997-04-01

    Full Text Available Neurons which release atrial natriuretic peptide (ANPergic neurons have their cell bodies in the paraventricular nucleus and in a region extending rostrally and ventrally to the anteroventral third ventricular (AV3V region with axons which project to the median eminence and neural lobe of the pituitary gland. These neurons act to inhibit water and salt intake by blocking the action of angiotensin II. They also act, after their release into hypophyseal portal vessels, to inhibit stress-induced ACTH release, to augment prolactin release, and to inhibit the release of LHRH and growth hormone-releasing hormone. Stimulation of neurons in the AV3V region causes natriuresis and an increase in circulating ANP, whereas lesions in the AV3V region and caudally in the median eminence or neural lobe decrease resting ANP release and the response to blood volume expansion. The ANP neurons play a crucial role in blood volume expansion-induced release of ANP and natriuresis since this response can be blocked by intraventricular (3V injection of antisera directed against the peptide. Blood volume expansion activates baroreceptor input via the carotid, aortic and renal baroreceptors, which provides stimulation of noradrenergic neurons in the locus coeruleus and possibly also serotonergic neurons in the raphe nuclei. These project to the hypothalamus to activate cholinergic neurons which then stimulate the ANPergic neurons. The ANP neurons stimulate the oxytocinergic neurons in the paraventricular and supraoptic nuclei to release oxytocin from the neural lobe which circulates to the atria to stimulate the release of ANP. ANP causes a rapid reduction in effective circulating blood volume by releasing cyclic GMP which dilates peripheral vessels and also acts within the heart to slow its rate and atrial force of contraction. The released ANP circulates to the kidney where it acts through cyclic GMP to produce natriuresis and a return to normal blood volume

  16. 76 FR 16285 - Amendments to the Water Quality Regulations, Water Code and Comprehensive Plan To Update Water...

    Science.gov (United States)

    2011-03-23

    ... DELAWARE RIVER BASIN COMMISSION 18 CFR Part 410 Amendments to the Water Quality Regulations, Water Code and Comprehensive Plan To Update Water Quality Criteria for Toxic Pollutants in the Delaware... or ``Commission'') approved amendments to its Water Quality Regulations, Water Code and Comprehensive...

  17. Water-body use by Asian elephants in Southern Sri Lanka

    OpenAIRE

    Pastorini, J; Nishantha, H G; Janaka, H K; Isler, K; Prithiviraj, F

    2010-01-01

    We assessed water-body use by elephants through monitoring elephant signs around them. Elephant footprints and dung piles were recorded at 25 water bodies fortnightly for one year. Elephants preferred perennial water bodies and avoided those with temporary human dwellings. Human activities did not significantly affect elephant use of water bodies, suggesting low incidence of activities and behavioral adaptation to them by elephants. Elephant signs at perennial water bodies increased in the dr...

  18. Body composition and water metabolism in tropical ruminants using tritiated water

    International Nuclear Information System (INIS)

    Ranjhan, S.K.; Kalanidhi, A.P.; Gosh, T.K.; Singh, U.B.; Saxena, K.K.

    1982-01-01

    Experiment 1. Studies were conducted on Muzaffarnagri, Muzaffarnagri x Dorset and Muzaffarnagri x Suffolk breeds of sheep to determine the water turnover rates and body composition. The native Muzaffarnagri and crossbred animals did not differ significantly in body composition. The water turnover rates were not significantly different between breeds within the same season, but a significant difference was observed between the two seasons (winter and summer). Experiment 2. Nine animals, three each of crossbred cattle (Hariana x Holstein), buffalo and crossbred sheep (Muzaffarnagri x Suffolk), were used to determine the body composition by the indirect method in the two seasons. There was a reduction in the TOH space and total body water during the summer season in cattle and buffalo as compared with the winter season. Experiment 3. Four adult Barbari goats were used to study body composition by direct (slaughter) and indirect (isotope dilution) techniques. There was a significant correlation between corrected TOH space and total body water, fat and protein. Experiment 4. Twelve animals, three each of buffalo, crossbred cattle (Hariana x Holstein), crossbred sheep (Muzaffarnagri x Suffolk) and Barbari goats, were used to determine the water requirements during the two seasons (winter and summer) by the tritiated water (TOH) dilution technique. There were significant differences (P < 0.01) in the water requirement and water turnover between seasons and between species within a season. The lowest water turnover and water requirement were found in goats, followed by sheep, crossbred cattle and buffalo when expressed as ml/kgsup(0.82).d. The metabolic water production was 10% of the total water input in the case of buffalo and crossbred cattle, but it was more in sheep and goats in both seasons

  19. Neonatal body water turnover: a putative index of perinatal morbidity

    International Nuclear Information System (INIS)

    MacLennan, A.H.; Millington, G.; Grieve, A.; McIntosh, J.E.; Seamark, R.F.; Cox, L.W.

    1981-01-01

    The water metabolism of 46 newborn babies was determined during a 10 day period by means of an isotope dilution technique, and correlations were sought with the clinical assessment of the babies by multiple obstetric and pediatric clinical criteria. The babies, 48 to 72 hours of age, were given a single oral dose (2 ml/kg) of deuterated water (D 2 O), a nonradioactive tracer, and the urinary excretion rate was followed by means of infrared spectrophotometry. After a period of equilibration of the D 2 O with body water (20 hours), the rate of D2O clearance was found to be a single exponential decay process, thus allowing the fraction of total body water lost each hour (the rate constant) to be calculated for each baby. The median values of the rate constants X 10(4)(h-1) for 14 growth-retarded babies ws 104 (98% confidence limits, 97.8 to 122) compared with 76.3 (67.0 to 80.2) for 16 normal mature babies and 82.1 (73.4 to 90.6) for 16 normal premature babies. These data indicate that, compared with normal mature or normal premature babies, growth-retarded infants have a significantly (P less than 0.05) faster turnover of water during the first 10 days of postnatal life. Since there was little overlap in results between the normally grown and the retarded infants, the measurement of water turnover may provide a useful index of perinatal morbidity

  20. Tritium content in tissue free water of Japanese bodies

    Energy Technology Data Exchange (ETDEWEB)

    Ujeno, Y.; Yamamoto, K.; Aoki, T.; Kurihara, N.

    1986-01-01

    The tritium content of tissue free water was measured in fresh, non-diseased organs (brain, lungs, liver, kidneys and muscle) removed by forensic autopsy from 4 male and 4 female bodies. Tissue free water was extracted by freeze drying and distillation and tritium measured in the absence of background radon gas. A typical count was approximately 2.70 cpm. The mean tritium content of tissue free water in all the organs examined was 2.50 + - 0.67 Bq.1/sup -1/ (67.6 + -18.2 pCi1/sup -1/). This value was much lower than that obtained for tissues from Italian bodies: the value was, however, similar to that obtained for tap water (70.2 + -28.0 pCi.1/sup -1/), rain water (77.8 + - 47.4 pCi.1/sup -1/) and tissue free water of foods (55.6 + - 26.2 pCi.1/sup -1/).

  1. Labelled Substrate Assays of Anticholinesterase Activity in Hungarian Water Bodies

    International Nuclear Information System (INIS)

    Horváth, L.

    1981-01-01

    At Budapest the River Danube divides into two branches. The left branch called Soroksár-Danube is regulated by locks. The water level fluctuation on this quasi lake is only 50-60 cm. Along the 57 km long branch there are big industries, intensive agricultural areas and holiday resorts. The water is used among others for irrigation, for fishponds and for water sport. The pesticides applied on the neighbouring arable land and the insecticides used for mosquito controlling may pollute the water. Little is known about the fate of insecticides in water and about their impact on the aquatic biota. In June 1978 a monitoring programme of cholinesterase inhibiting pesticide residues was launched on a section of River Danube near to Budapest. Important purpose of the investigations was to test the labelled substrate enzyme inhibition assay as monitoring method for pesticide residues

  2. Labelled Substrate Assays of Anticholinesterase Activity in Hungarian Water Bodies

    Energy Technology Data Exchange (ETDEWEB)

    Horváth, L. [Institute of Isotopes of the Hungarian Academy of Sciences, Budapest (Hungary)

    1981-05-15

    At Budapest the River Danube divides into two branches. The left branch called Soroksár-Danube is regulated by locks. The water level fluctuation on this quasi lake is only 50-60 cm. Along the 57 km long branch there are big industries, intensive agricultural areas and holiday resorts. The water is used among others for irrigation, for fishponds and for water sport. The pesticides applied on the neighbouring arable land and the insecticides used for mosquito controlling may pollute the water. Little is known about the fate of insecticides in water and about their impact on the aquatic biota. In June 1978 a monitoring programme of cholinesterase inhibiting pesticide residues was launched on a section of River Danube near to Budapest. Important purpose of the investigations was to test the labelled substrate enzyme inhibition assay as monitoring method for pesticide residues.

  3. Regulation of glycogenolysis in the locust fat body during flight

    NARCIS (Netherlands)

    Marrewijk, W.J.A. van; Broek, A.Th.M. van den; Beenakkers, A.M.Th.

    1980-01-01

    Glycogen reserves in the fat body of Locusta migratoria decrease dramatically during the first two hours of flight. In fat body of rested locusts only 10% of glycogen phosphorylase occurs in the active form. The enzyme is activated significantly during flight, when up to one-third of the total

  4. Parasitic amoebae found in water bodies of Ukraine.

    Science.gov (United States)

    Patsyuk, Marina

    2017-12-01

    Two parasitic amoebian species are found in mollusks of the water bodies of Ukraine. Vahlkampfia sp. is found in hepatopankreas of Unio conus Spengler, 1793, and Acanthamoeba sp. is observed in mantle cavity of Viviparus viviparus Linnaeus, 1758. For these protist species, the mollusks are shown to be intermediate hosts where amoebae feed and reproduce. An experimental infection with Vahlkampfia sp. and Acanthamoeba sp. was not successful, no pathological changes in mollusks were observed. These amoebae are successfully cultured in fresh water and agar medium, hence we can safely consider them free-living. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Law 17.598 it founds as a desconcentrate body of the Executive Power, the Regulator Unit of energy and Water services (URSEA) and it determines aims and integration

    International Nuclear Information System (INIS)

    2002-01-01

    URSEA is created whose activities are executed in accordance with the following objectives: the extension and universalization of access to cruelty, promoting optimal levels of investment for the provision of services under the conditions set by the sectoral regulation, the protection of environment, security of supply adequate protection of the rights of users and consumers, promotion of competition in the provision, delivery egalitarian, free choice for users among different providers, based on clear information and time, the application tariffs that reflect economic costs as applicable.

  6. Re-designating water bodies in Denmark bypasses the Water Framework Directive objectives

    DEFF Research Database (Denmark)

    Baaner, Lasse

    2015-01-01

    Despite the initially ambitious provisions of the Water Framework Directive (WFD) when it first entered into force, thousands of kilometres of Danish watercourses have now lost their legal protection through the application of the WFD’s provisions concerning the designation of water bodies....... This article describes the designation process and concludes that it does not conform to the obligation carefully to assign an environmental objective to discrete and significant water bodies as set out in the WFD. Neither does it ensure the same level of protection that existed prior to the implementation...

  7. Re-designating water bodies in Denmark bypasses the Water Framework Directive objectives

    DEFF Research Database (Denmark)

    Baaner, Lasse

    2017-01-01

    Despite the initially ambitious provisions of the Water Framework Directive (WFD) when it first entered into force, thousands of kilometres of Danish watercourses have now lost their legal protection through the application of the WFD’s provisions concerning the designation of water bodies....... This article describes the designation process and concludes that it does not conform to the obligation carefully to assign an environmental objective to discrete and significant water bodies as set out in the WFD. Neither does it ensure the same level of protection that existed prior to the implementation...

  8. Bacterial diversity and ecological function in lake water bodies

    OpenAIRE

    Lijuan Ren; Dan He; Peng Xing; Yujing Wang; Qinglong Wu

    2013-01-01

    The healthy development of lake ecosystems is a global issue. Bacteria are not only an integral component of food webs, but also play a key role in controlling and regulating water quality in lake ecosystems. Hence, in order to provide some suggestions for maintaining the long-term and healthy development of lake ecosystems, this review discusses and analyses concepts and assessment of bacterial diversity, the distribution of bacteria communities, mechanisms of formation, and the ecological f...

  9. Regulation of body temperature by some Mesozoic marine reptiles.

    Science.gov (United States)

    Bernard, Aurélien; Lécuyer, Christophe; Vincent, Peggy; Amiot, Romain; Bardet, Nathalie; Buffetaut, Eric; Cuny, Gilles; Fourel, François; Martineau, François; Mazin, Jean-Michel; Prieur, Abel

    2010-06-11

    What the body temperature and thermoregulation processes of extinct vertebrates were are central questions for understanding their ecology and evolution. The thermophysiologic status of the great marine reptiles is still unknown, even though some studies have suggested that thermoregulation may have contributed to their exceptional evolutionary success as apex predators of Mesozoic aquatic ecosystems. We tested the thermal status of ichthyosaurs, plesiosaurs, and mosasaurs by comparing the oxygen isotope compositions of their tooth phosphate to those of coexisting fish. Data distribution reveals that these large marine reptiles were able to maintain a constant and high body temperature in oceanic environments ranging from tropical to cold temperate. Their estimated body temperatures, in the range from 35 degrees +/- 2 degrees C to 39 degrees +/- 2 degrees C, suggest high metabolic rates required for predation and fast swimming over large distances offshore.

  10. Regulation of Water in Plant Cells

    Science.gov (United States)

    Kowles, Richard V.

    2010-01-01

    Cell water relationships are important topics to be included in cell biology courses. Differences exist in the control of water relationships in plant cells relative to control in animal cells. One important reason for these differences is that turgor pressure is a consideration in plant cells. Diffusion and osmosis are the underlying factors…

  11. Prostaglandins - universal biological regulators in the human body (literature review

    Directory of Open Access Journals (Sweden)

    О. V. Tymoshchuk

    2018-02-01

    Full Text Available Recently, researchers of different industries pay great attention to the problem of prostaglandins. Objective: to study and systematize the basic questions of structure, biological action and metabolism of prostaglandins in the human body and using their analogues in pharmacy through the domestic and foreign literature data analysis. Prostaglandins – biologically active substances which are similar in effect to hormones, but are synthesized in cells of different tissues. Prostaglandins as universal cellular mediators are widely distributed in the body, synthesized in small amounts in almost all tissues, have both local and systemic effects. For each prostaglandin there is a target organ. On chemical structure they are small molecules related to eicosanoids - a group of fat-like substances (lipids. Depending on the chemical structure prostaglandins are divided into series (A, B, C, D, E, F, G, H, I and J and three groups (1–3; type F isomers are to be indicated by additional letters α and β. Prostaglandins have an extremely wide range of physiological effects in the body and have three main functions: supporting, molecular, neurotransmitter. Most prostaglandins interact with specific receptors of plasma membranes, but some prostaglandins (group A can act without receptors. There is no stock of prostaglandins in the body, their life cycle is short, and they are quickly produced in response to biological stimulants exposure, have their effect in extremely small quantity and are rapidly inactivated in the bloodstream. Due to the extremely rapid breakdown of prostaglandins in the body they work near their place of secretion. Preparations of prostaglandins and their derivatives are used in experimental and clinical medicine for abortion and induction of labor, treatment of stomach ulcers, asthma, certain heart diseases, congenital heart defects in newborns, glaucoma, atherosclerosis, rheumatic and neurological diseases, kidney diseases, diabetes

  12. "Body Work--Regulation of a Swimmer Body": An Autoethnography from an Australian Elite Swimmer

    Science.gov (United States)

    McMahon, Jenny; DinanThompson, Maree

    2011-01-01

    This paper contributes to studies on sociology and the body by exploring my bodily experiences as an Australian elite swimmer in an autoethnographic framework. More specifically, it focuses on the relationship between the regulatory practices of others on my body and my development of self-regulatory practices. The stories in this paper reveal…

  13. Eating Regulation Styles, Appearance Schemas, and Body Satisfaction Predict Changes in Body Fat for Emerging Adults

    Science.gov (United States)

    Morgan, Ali Zaremba; Keiley, Margaret K.; Ryan, Aubrey E.; Radomski, Juliana Groves; Gropper, Sareen S.; Connell, Lenda Jo; Simmons, Karla P.; Ulrich, Pamela V.

    2012-01-01

    Obesity and high body fat percentages are a major public health issue. The percentage of obese and overweight Americans has increased over the past 30 years. On average, overweight individuals with higher percent body fat than normal weight individuals are at increased risk for numerous negative outcomes both physically and mentally. A prime time…

  14. Considering an affect regulation framework for examining the association between body dissatisfaction and positive body image in Black older adolescent females: does body mass index matter?

    Science.gov (United States)

    Webb, Jennifer B; Butler-Ajibade, Phoebe; Robinson, Seronda A

    2014-09-01

    The present study provided an initial evaluation of an affect regulation model describing the association between body dissatisfaction and two contemporary measures of positive body image among 247 Black college-bound older adolescent females. We further tested whether possessing a higher body mass index (BMI) would strengthen these associations. Self-reported height and weight were used to calculate BMI. Respondents also completed a culturally-sensitive figure rating scale along with assessments of body appreciation and body image flexibility. Results indicated a robust positive association between the two measures of positive body image; BMI was the strongest predictor of both body appreciation and body image flexibility with body size discrepancy (current minus ideal) contributing incremental variance to both models tested. Implications for improving our understanding of the association between positive and negative body image and bolstering positive body image to promote health-protective behaviors among Black young women at this developmental juncture are discussed. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. CNS β3-adrenergic receptor activation regulates feeding behavior, white fat browning, and body weight.

    Science.gov (United States)

    Richard, Jennifer E; López-Ferreras, Lorena; Chanclón, Belén; Eerola, Kim; Micallef, Peter; Skibicka, Karolina P; Wernstedt Asterholm, Ingrid

    2017-09-01

    Pharmacological β 3 -adrenergic receptor (β 3 AR) activation leads to increased mitochondrial biogenesis and activity in white adipose tissue (WAT), a process commonly referred to as "browning", and transiently increased insulin release. These effects are associated with improved metabolic function and weight loss. It is assumed that this impact of β 3 AR agonists is mediated solely through activation of β 3 ARs in adipose tissue. However, β 3 ARs are also found in the brain, in areas such as the brain stem and the hypothalamus, which provide multisynaptic innervation to brown and white adipose depots. Thus, contrary to the current adipocentric view, the central nervous system (CNS) may also have the ability to regulate energy balance and metabolism through actions on central β 3 ARs. Therefore, this study aimed to elucidate whether CNS β 3 ARs can regulate browning of WAT and other aspects of metabolic regulation, such as food intake control and insulin release. We found that acute central injection of β 3 AR agonist potently reduced food intake, body weight, and increased hypothalamic neuronal activity in rats. Acute central β 3 AR stimulation was also accompanied by a transient increase in circulating insulin levels. Moreover, subchronic central β 3 AR agonist treatment led to a browning response in both inguinal (IWAT) and gonadal WAT (GWAT), along with reduced GWAT and increased BAT mass. In high-fat, high-sugar-fed rats, subchronic central β 3 AR stimulation reduced body weight, chow, lard, and sucrose water intake, in addition to increasing browning of IWAT and GWAT. Collectively, our results identify the brain as a new site of action for the anorexic and browning impact of β 3 AR activation. Copyright © 2017 the American Physiological Society.

  16. Antioxidant activity of water extracts from fruit body of Lentinus edodes enriched with selenium

    Directory of Open Access Journals (Sweden)

    Savić Milena D.

    2011-01-01

    Full Text Available Shiitake (Lentinus edodes belongs to medically important and delicious fungi. It is recognizable for its healing properties, excellent taste and rich aroma. According to the traditional Japanese and Chinese medicine, shiitake mushroom significantly increases the strength and vitality of the body. Shiitake contains immunostimulants, compounds that lower cholesterol, prevents clogging of blood vessels, regulates the pressure, balances blood sugar levels, regulates digestion, and improves the performance of respiratory organs by its antirheumatic and antiallergic activities. Shiitake is recommended to use as food, prevention and cure, usually in a form of a spice (dried and ground or tea. It can be consumed fresh, too. The objective of this study was to test the effect of enrichment in selenium on antioxidant, reducing and free radical scavenging activity of water extracts from fruit body of Lentinus edodes. The fungus was enhanced by adding organic selenium, zinc (II complex with the ligand 2.6-bis diacetylpyridine (selenosemicarbazon and inorganic compounds (Na2SeO3 of selenium in nutritional substrate where the fungus was grown. The total selenium content in fruit body was around 50 ppm for the sample enriched with selenium originating from organic sources, and 80 ppm for the sample enriched with selenium from inorganic sources. Samples were prepared by extraction of fruiting bodies in heated water. The results indicated that water extracts of whole fruit bodies, from both control and mushrooms supplemented with selenium, had quite good antioxidant activity. However, there was no significant difference between the samples supplemented with selenium content and those that were not.

  17. Regulation of body fat mass by the gut microbiota

    DEFF Research Database (Denmark)

    Schéle, Erik; Grahnemo, Louise; Anesten, Fredrik

    2016-01-01

    New insight suggests gut microbiota as a component in energy balance. However, the underlying mechanisms by which gut microbiota can impact metabolic regulation is unclear. A recent study from our lab shows, for the first time, a link between gut microbiota and energy balance circuitries...

  18. Spatial Variability of Wet Troposphere Delays Over Inland Water Bodies

    Science.gov (United States)

    Mehran, Ali; Clark, Elizabeth A.; Lettenmaier, Dennis P.

    2017-11-01

    Satellite radar altimetry has enabled the study of water levels in large lakes and reservoirs at a global scale. The upcoming Surface Water and Ocean Topography (SWOT) satellite mission (scheduled launch 2020) will simultaneously measure water surface extent and elevation at an unprecedented accuracy and resolution. However, SWOT retrieval accuracy will be affected by a number of factors, including wet tropospheric delay—the delay in the signal's passage through the atmosphere due to atmospheric water content. In past applications, the wet tropospheric delay over large inland water bodies has been corrected using atmospheric moisture profiles based on atmospheric reanalysis data at relatively coarse (tens to hundreds of kilometers) spatial resolution. These products cannot resolve subgrid variations in wet tropospheric delays at the spatial resolutions (of 1 km and finer) that SWOT is intended to resolve. We calculate zenith wet tropospheric delays (ZWDs) and their spatial variability from Weather Research and Forecasting (WRF) numerical weather prediction model simulations at 2.33 km spatial resolution over the southwestern U.S., with attention in particular to Sam Rayburn, Ray Hubbard, and Elephant Butte Reservoirs which have width and length dimensions that are of order or larger than the WRF spatial resolution. We find that spatiotemporal variability of ZWD over the inland reservoirs depends on climatic conditions at the reservoir location, as well as distance from ocean, elevation, and surface area of the reservoir, but that the magnitude of subgrid variability (relative to analysis and reanalysis products) is generally less than 10 mm.

  19. Increase of Total Body Water with Decrease of Body Mass while Running 100 km Nonstop--Formation of Edema?

    Science.gov (United States)

    Knechtle, Beat; Wirth, Andrea; Knechtle, Patrizia; Rosemann, Thomas

    2009-01-01

    We investigated whether ultraendurance runners in a 100-km run suffer a decrease of body mass and whether this loss consists of fat mass, skeletal muscle mass, or total body water. Male ultrarunners were measured pre- and postrace to determine body mass, fat mass, and skeletal muscle mass by using the anthropometric method. In addition,…

  20. Safe drinking water act: Amendments, regulations and standards

    International Nuclear Information System (INIS)

    Calabrese, E.J.; Gilbert, C.E.; Pastides, H.

    1989-01-01

    This book approaches the topic of safe drinking water by communicating how the EPA has responded to the mandates of Congress. Chapter 1 summarizes what is and will be involved in achieving safe drinking water. Chapter 2 describes the historical development of drinking water regulations. Chapter 3 summarizes the directives of the Safe Drinking Water Act Amendments of 1986. Chapters 4 through 9 discuss each phase of the regulatory program in turn. Specific problems associated with volatile organic chemicals, synthetic organics, inorganic chemicals, and microbiological contaminants are assessed in Chapter 4 and 5. The unique characteristics of radionuclides and their regulation are treated in Chapter 6. The disinfection process and its resultant disinfection by-products are presented in Chapter 7. The contaminant selection process and the additional contaminants to be regulated by 1989 and 1991 and in future years are discussed in Chapters 8 and 9. EPA's Office of Drinking Water's Health Advisory Program is explained in Chapter 10. The record of public water system compliance with the primary drinking water regulations is detailed in Chapter 11. Chapter 12 offers a nongovernmental perspective on the general quality of drinking water and how this is affected by a wide range of drinking water treatment technologies. Separate abstracts are processed for 5 chapters in this book for inclusion in the appropriate data bases

  1. Bromide space, total body water, and sick cell syndrome

    International Nuclear Information System (INIS)

    Schober, O.; Hundeshagen, H.; Lehr, L.

    1982-01-01

    Displacements of the bromide space (Br-82-C, as a marker for the extracellular fluid compartment) are caused by an enhanced anatomical space and/or increased permeability of cells to bromide. The ratio Br-82-C: total body water (TBW) was evaluated to be 0.83 +- 0.17 in critically ill patients (n = 38) compared with the normal value of 0.46 +- 0.04 (n = 10). Because of normal TBW in critically ill patients (TBW = 505 +- 68 ml/kg), an increased bromide penetration into cells seems to be responsible for the enlarged ratio Br-82-C: TBW. Taking into consideration measurements in patients with malabsorption (Br-82-C: TBW = 0.56 +- 0.13; n = 13) and carcinoma of the rectum and colon (Br-82-C: TBW = 0.66 +- 0.24; n = 18) we think that the bromide space is a good measurement of the effective extracellular water. (orig.)

  2. Climate change adaptation in regulated water utilities

    Science.gov (United States)

    Vicuna, S.; Melo, O.; Harou, J. J.; Characklis, G. W.; Ricalde, I.

    2017-12-01

    Concern about climate change impacts on water supply systems has grown in recent years. However, there are still few examples of pro-active interventions (e.g. infrastructure investment or policy changes) meant to address plausible future changes. Deep uncertainty associated with climate impacts, future demands, and regulatory constraints might explain why utility planning in a range of contexts doesn't explicitly consider climate change scenarios and potential adaptive responses. Given the importance of water supplies for economic development and the cost and longevity of many water infrastructure investments, large urban water supply systems could suffer from lack of pro-active climate change adaptation. Water utilities need to balance the potential for high regret stranded assets on the one side, with insufficient supplies leading to potentially severe socio-economic, political and environmental failures on the other, and need to deal with a range of interests and constraints. This work presents initial findings from a project looking at how cities in Chile, the US and the UK are developing regulatory frameworks that incorporate utility planning under uncertainty. Considering for example the city of Santiago, Chile, recent studies have shown that although high scarcity cost scenarios are plausible, pre-emptive investment to guard from possible water supply failures is still remote and not accommodated by current planning practice. A first goal of the project is to compare and contrast regulatory approaches to utility risks considering climate change adaptation measures. Subsequently we plan to develop and propose a custom approach for the city of Santiago based on lessons learned from other contexts. The methodological approach combines institutional assessment of water supply regulatory frameworks with simulation-based decision-making under uncertainty approaches. Here we present initial work comparing the regulatory frameworks in Chile, UK and USA evaluating

  3. Epigenetic Regulation of Carotid Body Oxygen Sensing: Clinical Implications.

    Science.gov (United States)

    Nanduri, Jayasri; Prabhakar, Nanduri R

    2015-01-01

    Recurrent apnea with intermittent hypoxia (IH) is a major clinical problem in infants born preterm. Recent epidemiological studies showed that adults who were born preterm exhibit increased incidence of sleep-disordered breathing and hypertension. Thus, apnea of prematurity predisposes individuals to autonomic dysfunction in adulthood. Experimental studies showed that adult rats exposed to IH as neonates exhibit augmented carotid body and adrenal chromaffin cells (AMC) response to hypoxia and irregular breathing with apneas and hypertension. The enhanced hypoxic sensitivity of the carotid body and AMC in adult rats exposed to neonatal IH was associated with increased oxidative stress, decreased expression of genes encoding anti-oxidant enzymes, and increased expression of pro-oxidant enzymes. Epigenetic mechanisms including DNA methylation leads to long-term changes in gene expression. The decreased expression of the Sod2 gene, which encodes the anti-oxidant enzyme, superoxide dismutase 2, was associated with DNA hypermethylation of a single CpG dinucleotide close to the transcription start site. Treating neonatal rats with decitabine, an inhibitor of DNA methylation, during IH exposure prevented the oxidative stress, enhanced hypoxic sensitivity, and autonomic dysfunction in adult rats. These findings suggest that epigenetic mechanisms, especially DNA methylation contributes to neonatal programming of hypoxic sensitivity and the ensuing autonomic dysfunction in adulthood.

  4. 76 FR 295 - Proposed Amendments to the Water Quality Regulations, Water Code and Comprehensive Plan To...

    Science.gov (United States)

    2011-01-04

    ... and development of water resources of the Delaware River Basin during the implementation of natural... states and Federal government work together to manage water resources in an integrated manner for the... new Article 7 of DRBC's Water Quality Regulations to protect the water resources of the Basin during...

  5. Influence of a water regulation event on the age of Yellow River water in the Bohai

    Science.gov (United States)

    Li, Zhen; Wang, Haiyan; Guo, Xinyu; Liu, Zhe; Gao, Huiwang; Zhang, Guiling

    2017-10-01

    Abrupt changes in freshwater inputs from large rivers usually imply regime shifts in coastal water environments. The influence of a water regulation event on the age of the Yellow River water in the Bohai was modeled using constituent-oriented age and residence time theory to better understand the change in the environmental function of the hydrodynamic field owing to human activities. The water ages in Laizhou Bay, the central basin, and the Bohai strait are sensitive to water regulation. The surface ages in those areas can decrease by about 300 days, particularly in July, and the age stratification is also strengthened. A water regulation event can result in declines in the water age in early July ahead of declines in the water age under climatological conditions (without the regulation event) by about 1 and 5 months in the central basin and Laizhou Bay, respectively. The change in the coastal circulation due to the water regulation event is the primary reason for the change in the Yellow River water age. The high Yellow River flow rate can enhance the density flow and, therefore, reduce the age of the Yellow River water. The subsequent impact of a single water regulation event can last about 1.0 to 4.0 years in different subregions.

  6. Spatial variation in water quality within the water bodies of a Peak District catchment and the contribution of moorland condition

    Science.gov (United States)

    Crouch, Tia; Walker, Jonathan

    2013-04-01

    Spatial variation in water quality within the water bodies of a Peak District catchment and the contribution of moorland condition Tia Crouch and Jonathan Walker (Moors for the Future Partnership) Upland locations are significant water supply sources providing over 70% of fresh water in Great Britain. However, the peatlands of the Peak District, Southern Pennines are highly contaminated with anthropogenically derived, atmospherically deposited pollutants, such as heavy metals. This is due to their location between the cities of Manchester and Sheffield, the centre of the 19th century English Industrial Revolution. These peatlands are also severely eroded; therefore erosion could be releasing these pollutants into the fluvial system, representing a threat to both aquatic ecosystems and drinking water supplies. These threats are regulated under the Water Framework Directive (WFD) and the Water Supply Regulations respectively. There are two aims of this project. The first aim is to identify spatial and temporal variability of water quality within the Bamford water treatment works (WTW) catchment. This was achieved by fortnightly spot sampling at eight of the tributaries into the reservoir system. The second aim is to assess the contribution of moorland condition to water quality within the Bamford WTW catchment. Similarly, this was achieved by fortnightly spot sampling at eight moorland streams, draining from a variety of peatland conditions (bare peat, restoration, intact and heather burn). Water samples were analysed for carbon (DOC, POC & TOC), pH, hardness and a suite of heavy metals, including copper, iron and zinc. In addition, stream temperature and stage height was recorded. Preliminary results highlight a number of issues within the Bamford WTW catchment: under the WFD streams are not achieving 'good' status for pH, copper and zinc, and under the Drinking Water Standards (DWS) streams are not achieving targets for aluminium, iron and colour. For example, the

  7. Association between body water status and acute mountain sickness.

    Directory of Open Access Journals (Sweden)

    Hannes Gatterer

    Full Text Available PURPOSE: The present study determined the association between body fluid variation and the development of acute mountain sickness (AMS in adults. METHODS: Forty-three healthy participants (26 males and 17 females, age: 26 ± 6 yr, height: 174 ± 9 cm, weight: 68 ± 12 kg were passively exposed at a FiO2 of 12.6% (simulated altitude hypoxia of 4500 m, PiO2 = 83.9 mmHg for 12-h. AMS severity was assessed using the Lake Louise Score (LLS. Food and drink intakes were consumed ad libitum and measured; all urine was collected. Before and after the 12-h exposure, body weight and plasma osmolality were measured and whole-body bioimpedance analysis was performed. RESULTS: The overall AMS incidence was 43% (38% males, 50% females. Participants who developed AMS showed lower fluid losses (3.0 ± 0.9 vs. 4.5 ± 2.0 ml/kg/h, p = 0.002, a higher fluid retention (1.9 ± 1.5 vs. 0.6 ± 0.8 ml/kg/h, p = 0.022, greater plasma osmolality decreases (-7 ± 7 vs. -2 ± 5 mOsm/kg, p = 0.028 and a larger plasma volume expansion (11 ± 10 vs. 1 ± 15%, p = 0.041 compared to participants not developing AMS. Net water balance (fluid intake--fluid loss and the amount of fluid loss were strong predictors whether getting sick or not (Nagelkerkes r(2 = 0.532. The LLS score was related to net water balance (r = 0.358, p = 0.018, changes in plasma osmolality (r = -0.325, p = 0.033 and sodium concentration (r = -0.305, p = 0.047. Changes in the impedance vector length were related to weight changes (r = -0.550, p<0.001, fluid intake (r = -0.533, p<0.001 and net water balance (r = -0.590, p<0.001. CONCLUSIONS: Participants developing AMS within 12 hours showed a positive net water balance due to low fluid loss. Thus measures to avoid excess fluid retention are likely to reduce AMS symptoms.

  8. Regulation of glycogenesis in bone marrow of irradiated body

    Energy Technology Data Exchange (ETDEWEB)

    Barkalaya, A I

    1976-02-01

    In connection with a stimulating effect of insulin on postradiation restoration of medullary hemopoiesis the authors studied the influence of insulin on glycogenesis of bone marrow in comparison with glycogenesis of the liver under the conditions of irradiation. As a result the experiment made on white mice the authors established that the level of glycogen in both tissues on the first two days after irradiation (750 R) increased. Later, the decrease of glycogen concentration was observed and its exhaustion was more marked. Insulin protected bone marrow and the liver from exhaustion of glycogen reserves and ensured a higher level of glycogen in the liver. It is supposed that the regulation mechanisms by means of insulin of glycogenesis in the bone marrow and the liver are mainly of the same type. The influence of insulin on carbohydrate metabolism in the bone marrow is likely to be of significance for postradiation hemopoiesis.

  9. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

    NARCIS (Netherlands)

    C.J. Willer (Cristen); E.K. Speliotes (Elizabeth); R.J.F. Loos (Ruth); S. Li (Shengxu); C.M. Lindgren (Cecilia); I.M. Heid (Iris); S.I. Berndt (Sonja); A.L. Elliott (Amanda); A.U. Jackson (Anne); C. Lamina (Claudia); G. Lettre (Guillaume); N. Lim (Noha); H.N. Lyon (Helen); S.A. McCarroll (Steven); K. Papadakis (Konstantinos); L. Qi (Lu); J.C. Randall (Joshua); R.M. Roccasecca; S. Sanna (Serena); P. Scheet (Paul); M.N. Weedon (Michael); E. Wheeler (Eleanor); J.H. Zhao (Jing Hua); L.C. Jacobs (Leonie); I. Prokopenko (Inga); N. Soranzo (Nicole); T. Tanaka (Toshiko); N.J. Timpson (Nicholas); P. Almgren (Peter); A.J. Bennett (Amanda); R.N. Bergman (Richard); S. Bingham (Sheila); L.L. Bonnycastle (Lori); M.J. Brown (Morris); N.P. Burtt (Noël); P.S. Chines (Peter); L. Coin (Lachlan); F.S. Collins (Francis); J. Connell (John); C. Cooper (Charles); G.D. Smith; E.M. Dennison (Elaine); P. Deodhar (Parimal); M.R. Erdos (Michael); K. Estrada Gil (Karol); D.M. Evans (David); L. Gianniny (Lauren); C. Gieger (Christian); C.J. Gillson (Christopher); C. Guiducci (Candace); R. Hackett (Rachel); D. Hadley (David); A.S. Hall (Alistair); A.S. Havulinna (Aki); J. Hebebrand (Johannes); A. Hofman (Albert); B. Isomaa (Bo); T. Johnson (Toby); P. Jousilahti (Pekka); Z. Jovanovic (Zorica); K-T. Khaw (Kay-Tee); P. Kraft (Peter); M. Kuokkanen (Mikko); J. Kuusisto (Johanna); J. Laitinen (Jaana); E. Lakatta (Edward); J. Luan; R.N. Luben (Robert); M. Mangino (Massimo); W.L. McArdle (Wendy); T. Meitinger (Thomas); A. Mulas (Antonella); P. Munroe (Patricia); N. Narisu (Narisu); A.R. Ness (Andrew); K. Northstone (Kate); S. O'Rahilly (Stephen); C. Purmann (Carolin); M.G. Rees (Matthew); M. Ridderstråle (Martin); S.M. Ring (Susan); F. Rivadeneira Ramirez (Fernando); A. Ruokonen (Aimo); M.S. Sandhu (Manjinder); J. Saramies (Jouko); L.J. Scott (Laura); A. Scuteri (Angelo); K. Silander (Kaisa); M.A. Sims (Matthew); K. Song (Kijoung); J. Stephens (Jonathan); S. Stevens (Suzanne); H.M. Stringham (Heather); Y.C.L. Tung (Loraine); T.T. Valle (Timo); P. Tikka-Kleemola (Päivi); K.S. Vimaleswaran (Karani); P. Vollenweider (Peter); G. Waeber (Gérard); C. Wallace (Chris); R.M. Watanabe (Richard); D. Waterworth (Dawn); N. Watkins (Nicholas); J.C.M. Witteman (Jacqueline); E. Zeggini (Eleftheria); G. Zhai (Guangju); M.C. Zillikens (Carola); D. Altshuler (David); M. Caulfield (Mark); S.J. Chanock (Stephen); I.S. Farooqi (Sadaf); L. Ferrucci (Luigi); J.M. Guralnik (Jack); A.T. Hattersley (Andrew); F.B. Hu (Frank); M.-R. Jarvelin (Marjo-Riitta); M. Laakso (Markku); V. Mooser (Vincent); K.K. Ong (Ken); W.H. Ouwehand (Willem); V. Salomaa (Veikko); N.J. Samani (Nilesh); T.D. Spector (Timothy); T. Tuomi (Tiinamaija); J. Tuomilehto (Jaakko); M. Uda (Manuela); A.G. Uitterlinden (André); P. Deloukas (Panagiotis); N.J. Wareham (Nick); T.M. Frayling (Timothy); L. Groop (Leif); R.B. Hayes (Richard); D. Hunter (David); K.L. Mohlke (Karen); L. Peltonen (Leena Johanna); D. Schlessinger (David); D.P. Strachan (David); H.E. Wichmann (Erich); M.I. McCarthy (Mark); M. Boehnke (Michael); I.E. Barroso (Inês); G.R. Abecasis (Gonçalo); J.N. Hirschhorn (Joel)

    2009-01-01

    textabstractCommon variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts

  10. The hole picture: risks, decision making, purpose, regulations, and the future of body piercing.

    Science.gov (United States)

    Armstrong, Myrna L; Koch, Jerome R; Saunders, Jana C; Roberts, Alden E; Owen, Donna C

    2007-01-01

    Can it be said that body piercing is ubiquitous, found across all socioeconomic groups? The major concentration is among adolescents and young adults 15 to 30 years old, in some studies, 50% of the population. Commonly identified physical risks are bleeding, tissue trauma, and bacterial infections; psychosocial risks are unhappiness, low self-esteem, and disappointment. The Health Belief Model is used to explain decision making; purposes for body piercing consistently center on personal expression (self-identity) and uniqueness. The international and US body piercing regulations are discussed, leading to the need for tracking complications globally and standardization of regulations. Proactive health education for clients and health providers remains a priority.

  11. Viscosity of interfacial water regulates ice nucleation

    International Nuclear Information System (INIS)

    Li, Kaiyong; Chen, Jing; Zhang, Qiaolan; Zhang, Yifan; Xu, Shun; Zhou, Xin; Cui, Dapeng; Wang, Jianjun; Song, Yanlin

    2014-01-01

    Ice formation on solid surfaces is an important phenomenon in many fields, such as cloud formation and atmospheric icing, and a key factor for applications in preventing freezing. Here, we report temperature-dependent nucleation rates of ice for hydrophilic and hydrophobic surfaces. The results show that hydrophilic surface presents a lower ice nucleation rate. We develop a strategy to extract the thermodynamic parameters, J 0 and Γ, in the context of classical nucleation theory. From the extracted J 0 and Γ, we reveal the dominant role played by interfacial water. The results provide an insight into freezing mechanism on solid surfaces

  12. Whole body immersion and hydromineral homeostasis: effect of water temperature.

    Science.gov (United States)

    Jimenez, Chantal; Regnard, Jacques; Robinet, Claude; Mourot, Laurent; Gomez-Merino, Danielle; Chennaoui, Mounir; Jammes, Yves; Dumoulin, Gilles; Desruelle, Anne-Virginie; Melin, Bruno

    2010-01-01

    This experiment was designed to assess the effects of prolonged whole body immersion (WBI) in thermoneutral and cold conditions on plasma volume and hydromineral homeostasis.10 navy "combat swimmers" performed three static 6-h immersions at 34 degrees C (T34), 18 degrees C (T18) and 10 degrees C (T10). Rectal temperature, plasma volume (PV) changes, plasma proteins, plasma and urine ions, plasma osmolality, renin, aldosterone and antidiuretic hormone (ADH) were measured. Results show that compared to pre-immersion levels, PV decreased throughout WBI sessions, the changes being markedly accentuated in cold conditions. At the end of WBI, maximal PV variations were -6.9% at T34, -14.3% at T18, and -16.3% at T10. Plasma osmolality did not change during and after T34 immersion, while hyperosmolality was present at the end of T18 immersion and began after only 1 h of T10 immersion. In the three temperature conditions, significant losses of water (1.6-1.7 l) and salt (6-8 g) occurred and were associated with similar increases in osmolar and free water clearances. Furthermore, T18 and T10 immersions increased the glomerular filtration rate. There was little or no change in plasma renin and ADH, while the plasma level of aldosterone decreased equally in the three temperature conditions. In conclusion, our data indicate that cold water hastened PV changes induced by immersion, and increased the glomerular filtration rate, causing larger accumulated water losses. The iso-osmotic hypovolemia may impede the resumption of baseline fluid balance. Results are very similar to those repeatedly described by various authors during head-out water immersion.

  13. Does body mass play a role in the regulation of food intake?

    Science.gov (United States)

    Speakman, John R; Stubbs, R James; Mercer, Julian G

    2002-11-01

    It is widely believed that body fatness (and hence total body mass) is regulated by a lipostatic feedback system. This system is suggested to involve at least one peripheral signalling compound, which signals to the brain the current size of body fat stores. In the brain the level of the signal is compared with a desirable target level, and food intake and energy expenditure are then regulated to effect changes in the size of body fat stores. There is considerable support for this theory at several different levels of investigation. Patterns of body-mass change in subjects forced into energy imbalance seem to demonstrate homeostasis, and long-term changes in body mass are minor compared with the potential changes that might result from energy imbalance. Molecular studies of signalling compounds have suggested a putative lipostatic signal (leptin) and a complex network of downstream processing events in the brain, polymorphisms of which lead to disruption of body-mass regulation. This network of neuropeptides provides a rich seam of potential pharmaceutical targets for the control of obesity. Despite this consistent explanation for the observed phenomena at several different levels of enquiry, there are alternative explanations. In the present paper we explore the possibility that the existence of lipostatic regulation of body fatness is an illusion generated by the links between body mass and energy expenditure and responses to energy imbalance that are independent of body mass. Using computer-based models of temporal patterns in energy balance we show that common patterns of change in body mass following perturbation can be adequately explained by this 'non-lipostatic' model. This model has some important implications for the interpretations that we place on the molecular events in the brain, and ultimately in the search for pharmaceutical agents for alleviation of obesity.

  14. Water phantom explorer regulated by computer

    Energy Technology Data Exchange (ETDEWEB)

    Daniel, G [Centre Henri Becquerel, 76 - Rouen (France); Sarrau, J M; Bouet, M [ERA CNRS, UER Sciences et Techniques de Rouen, 76 - Mont-Saint-Aignan (France)

    1983-01-01

    A water phantom device is meant to work directly with a Hewlett-Packard 9825 T small computer. The purpose of this work is to read the distribution of absorbed dose released into a perspex container of water with the help of a semiconductor detector which can move in the three dimensions of space. Above the container a second detector situated on the edge of the beam is used as a monitor. The execution of the programmes written in HPL (Hewlett-Packard Language) offers the possibility either to carry out a preprogrammed cycle of displacements and measures or to work in interacting mode. The collected measures (space, co-ordinates and dose measures) are visualized by a plotter and recorded on a cassette tape. The signals delivered by the detectors are amplified separately then a dividing circuit delivers a tension in proportion with the ratio of these two signals. This tension is independent of the dose rate fluctuations of the irradiation beam and can be read by the computer. The examples of study of photon and electron beams that are described hereafter are meant to show the interest of a command that can be programmed.

  15. Proposal of guidelines for structuring an independent regulation body for the Brazilian nuclear sector

    International Nuclear Information System (INIS)

    Nicoll Junior, Ricardo

    2016-01-01

    Regulatory bodies are responsible for regulation in various sectors of society. In Brazil, they work in various areas for the development of the country and have as main objective the social, economic and national development. The progress of new technologies in the nuclear field and their commercialization underscores the need for regulation according to international safety standards. The present research searches through an extensive review of the literature identify the international guidelines for regulatory bodies and make a comparative analysis between Brazil and five countries that have independent regulatory bodies in the nuclear sector. The purpose of the work is to contribute to the Brazilian public sectors, with an evaluation of the country's regulation in the perception of specialists and propose guidelines for the structuring of an independent regulatory body, respecting international agreements and the legislation in force in the country. (author)

  16. Comparison of total body water determinations in lactating women by anthropometry, water displacement, and deuterium isotope dilution

    International Nuclear Information System (INIS)

    Wong, W.; Butte, N.; Lee, L.; Garza, C.; Klein, P.

    1986-01-01

    To expand the limited data on the total body water in lactating women, the authors have determined total body water contents, in eight subjects from anthropometric measurements, water displacement, and isotope dilution of deuterium oxide. On the day of the study, their skinfold thicknesses were measured over the biceps and triceps muscles and at the suprailiac and subscapular areas. Their body densities were measured by water displacement. Deuterium oxide was administered orally at 100 mg/kg of body weight. One predose milk sample was collected from each subject. The milk samples were defatted by centrifugation and the milk water was reduced to hydrogen gas for hydrogen isotope ratio measurements by gas-isotope-ratio mass spectrometry. The results indicated that total body water in lactating women estimated from anthropometric measurements was 49.7 +/- 3.3% of body weight, by water displacement was 54.9 +/- 7.2%, and by isotope dilution was 50.8 +/- 3.7%

  17. Ghrelin in the regulation of body weight and metabolism.

    Science.gov (United States)

    Castañeda, T R; Tong, J; Datta, R; Culler, M; Tschöp, M H

    2010-01-01

    Ghrelin, a peptide hormone predominantly produced by the stomach, was isolated as the endogenous ligand for the growth hormone secretagogue receptor. Ghrelin is a potent stimulator of growth hormone (GH) secretion and is the only circulatory hormone known to potently enhance feeding and weight gain and to regulate energy homeostasis following central and systemic administration. Therapeutic intervention with ghrelin in catabolic situations may induce a combination of enhanced food intake, increased gastric emptying and nutrient storage, coupled with an increase in GH thereby linking nutrient partitioning with growth and repair processes. These qualities have fostered the idea that ghrelin-based compounds may have therapeutic utility in treating malnutrition and wasting induced by various sub-acute and chronic disorders. Conversely, compounds that inhibit ghrelin action may be useful for the prevention or treatment of metabolic syndrome components such as obesity, impaired lipid metabolism or insulin resistance. In recent years, the effects of ghrelin on glucose homeostasis, memory function and gastrointestinal motility have attracted considerable amount of attention and revealed novel therapeutic targets in treating a wide range of pathologic conditions. Furthermore, discovery of ghrelin O-acyltransferase has also opened new research opportunities that could lead to major understanding of ghrelin physiology. This review summarizes the current knowledge on ghrelin synthesis, secretion, mechanism of action and biological functions with an additional focus on potential for ghrelin-based pharmacotherapies. 2009 Elsevier Inc. All rights reserved.

  18. Physical Activity Plays an Important Role in Body Weight Regulation

    Directory of Open Access Journals (Sweden)

    Jean-Philippe Chaput

    2011-01-01

    Full Text Available Emerging literature highlights the need to incorporate physical activity into every strategy intended to prevent weight gain as well as to maintain weight loss over time. Furthermore, physical activity should be part of any plan to lose weight. The stimulus of exercise provides valuable metabolic adaptations that improve energy and macronutrient balance regulation. A tight coupling between energy intake and energy expenditure has been documented at high levels of physical exercise, suggesting that exercise may improve appetite control. The regular practice of physical activity has also been reported to reduce the risk of stress-induced weight gain. A more personalized approach is recommended when planning exercise programs in a clinical weight loss setting in order to limit the compensatory changes associated to exercise-induced weight loss. With modern environment promoting overeating and sedentary behavior, there is an urgent need for a concerted action including legislative measures to promote healthy active living in order to curb the current epidemic of chronic diseases.

  19. In-vivo determination of total body water and lean body mass in subjects by deuterium dilution

    Energy Technology Data Exchange (ETDEWEB)

    Blagojevic, N; Allen, B J; Baur, L; Gaskin, K

    1988-12-01

    Total body water (TBW) estimation is one of a number of basic techniques required for the determination of body composition in normal and malnourished subjects. When combined with total body nitrogen (TBN) analysis by prompt gamma neutron activation, an accurate compartmental model of in vivo body composition can be formed, providing valuable nutritional and other data. This study examines the role of TBW on its own in evaluating lean body mass. Total body water was studied in six male and five female subjects using deuterium oxide and a Fourier transform infrared spectrometer. The lean body mass calculated from the results was compared with the lean body mass deduced from established total body nitrogen measurements. A four-compartment model was also used to calculate lean body mass. Excellent agreement was shown between lean body mass derived from TBW, the four-compartment model and TBN. Hence, TBW can provide a fast, cost-efficient method for evaluating normal subjects. However, for disease-induced malnutrition, or highly developed athletes, both TBN and TBW measurements are essential to establish an accurate picture of their body composition. TBW measurements alone can monitor the hydration state of patients and as such have a useful diagnostic value.

  20. In-vivo determination of total body water and lean body mass in subjects by deuterium dilution

    International Nuclear Information System (INIS)

    Blagojevic, N.; Allen, B.J.; Baur, L.; Gaskin, K.

    1988-01-01

    Total body water (TBW) estimation is one of a number of basic techniques required for the determination of body composition in normal and malnourished subjects. When combined with total body nitrogen (TBN) analysis by prompt gamma neutron activation, an accurate compartmental model of in vivo body composition can be formed, providing valuable nutritional and other data. This study examines the role of TBW on its own in evaluating lean body mass. Total body water was studied in six male and five female subjects using deuterium oxide and a Fourier transform infrared spectrometer. The lean body mass calculated from the results was compared with the lean body mass deduced from established total body nitrogen measurements. A four-compartment model was also used to calculate lean body mass. Excellent agreement was shown between lean body mass derived from TBW, the four-compartment model and TBN. Hence, TBW can provide a fast, cost-efficient method for evaluating normal subjects. However, for disease-induced malnutrition, or highly developed athletes, both TBN and TBW measurements are essential to establish an accurate picture of their body composition. TBW measurements alone can monitor the hydration state of patients and as such have a useful diagnostic value

  1. 75 FR 41106 - Amendments to the Water Quality Regulations, Water Code and Comprehensive Plan to Update Water...

    Science.gov (United States)

    2010-07-15

    ... DELAWARE RIVER BASIN COMMISSION 18 CFR Part 410 Amendments to the Water Quality Regulations, Water Code and Comprehensive Plan to Update Water Quality Criteria for Toxic Pollutants in the Delaware... hold a public hearing to receive comments on proposed amendments to the Commission's Water Quality...

  2. Turnover of body water in relation to the hydric diet studied with tritiated water in Locusta migratoria migratorioides

    International Nuclear Information System (INIS)

    Buscarlet, L.A.; Proux, Jacques

    1975-01-01

    The elimination of triated water injected in a locust Locusta migratoria migratorioides is described by an exponential function of the cumulative water diet and fits a one-compartment model. This result shows that body water occupies a single pool the mass of which is kept constant by an equilibrium between the water diet and the water elimination rate [fr

  3. Worldwide Eutrophication of Water Bodies: Causes, Concerns, Controls

    Science.gov (United States)

    Prepas, E. E.; Charette, T.

    2003-12-01

    Eutrophication is the nutrient enrichment of waters that stimulates an array of symptomatic changes, that can include increased phytoplankton and rooted aquatic plant (macrophyte) production, fisheries and water quality deterioration, and other undesirable changes that interfere with water uses (Bartsch, 1972). The trophic state, or degree of fertility, of water bodies ranges from oligotrophic to mesotrophic to eutrophic with increasing supply of nutrients and organic matter ( Table 1). Eutrophication is most often the result of an elevated supply of nutrients, particularly nitrogen and phosphorus, to surface waters that results in enhanced production of primary producers, particularly phytoplankton and aquatic plants. Table 1. Mean annual values for the trophic classification system Total phosphorus (μg L-1)Chlorophyll a (μg L-1)Secchi disk depth (m) Ultra-oligotrophic12 Oligotrophic6 Mesotrophic10-352.5-86-3 Eutrophic35-1008-253-1.5 Hypertrophic>100>25fish kills, millions of dollars in losses to seafood-related industries, human memory loss, paralysis, and even death (Van den Hoeck et al., 1995; Silbergeld et al., 2000). Bloom-forming species of cyanobacteria can produce potent hepato-(liver) toxins termed microcystins that have been implicated in poisonings of domestic livestock, pets, wildlife, and susceptible humans ( Codd, 1995; Dunn, 1996). In addition, an accumulation of dead phytoplankton in bottom waters of eutrophic systems can lead to high decomposition rates by bacteria. Dissolved oxygen consumption by decomposers, combined with a barrier to gas exchange (thermocline or ice cover), can reduce (hypoxia) or eliminate (anoxia) dissolved oxygen in bottom waters. (A thermocline is the junction between an upper layer of warm, less dense water (the epilimnion) and a deeper layer of cold water (the hypolimnion). When this stratification is in place, the typically oxygen-rich waters of the epilimnion do not mix with the waters of the hypolimnion.) Oxygen

  4. Neonatal immune challenge does not affect body weight regulation in rats.

    Science.gov (United States)

    Spencer, Sarah J; Mouihate, Abdeslam; Galic, Michael A; Ellis, Shaun L; Pittman, Quentin J

    2007-08-01

    The perinatal environment plays a crucial role in programming many aspects of adult physiology. Myriad stressors during pregnancy, from maternal immune challenge to nutritional deficiency, can alter long-term body weight set points of the offspring. In light of the increasing concern over body weight issues, such as obesity and anorexia, in modern societies and accumulating evidence that developmental stressors have long-lasting effects on other aspects of physiology (e.g., fever, pain), we explored the role of immune system activation during neonatal development and its impact on body weight regulation in adulthood. Here we present a thorough evaluation of the effects of immune system activation (LPS, 100 microg/kg ip) at postnatal days 3, 7, or 14 on long-term body weight, adiposity, and body weight regulation after a further LPS injection (50 microg/kg ip) or fasting and basal and LPS-induced circulating levels of the appetite-regulating proinflammatory cytokine leptin. We show that neonatal exposure to LPS at various times during the neonatal period has no long-term effects on growth, body weight, or adiposity. We also observed no effects on body weight regulation in response to a short fasting period or a further exposure to LPS. Despite reductions in circulating leptin levels in response to LPS during the neonatal period, no long-term effects on leptin were seen. These results convincingly demonstrate that adult body weight and weight regulation are, unlike many other aspects of adult physiology, resistant to programming by a febrile-dose neonatal immune challenge.

  5. Increased salt consumption induces body water conservation and decreases fluid intake.

    Science.gov (United States)

    Rakova, Natalia; Kitada, Kento; Lerchl, Kathrin; Dahlmann, Anke; Birukov, Anna; Daub, Steffen; Kopp, Christoph; Pedchenko, Tetyana; Zhang, Yahua; Beck, Luis; Johannes, Bernd; Marton, Adriana; Müller, Dominik N; Rauh, Manfred; Luft, Friedrich C; Titze, Jens

    2017-05-01

    The idea that increasing salt intake increases drinking and urine volume is widely accepted. We tested the hypothesis that an increase in salt intake of 6 g/d would change fluid balance in men living under ultra-long-term controlled conditions. Over the course of 2 separate space flight simulation studies of 105 and 205 days' duration, we exposed 10 healthy men to 3 salt intake levels (12, 9, or 6 g/d). All other nutrients were maintained constant. We studied the effect of salt-driven changes in mineralocorticoid and glucocorticoid urinary excretion on day-to-day osmolyte and water balance. A 6-g/d increase in salt intake increased urine osmolyte excretion, but reduced free-water clearance, indicating endogenous free water accrual by urine concentration. The resulting endogenous water surplus reduced fluid intake at the 12-g/d salt intake level. Across all 3 levels of salt intake, half-weekly and weekly rhythmical mineralocorticoid release promoted free water reabsorption via the renal concentration mechanism. Mineralocorticoid-coupled increases in free water reabsorption were counterbalanced by rhythmical glucocorticoid release, with excretion of endogenous osmolyte and water surplus by relative urine dilution. A 6-g/d increase in salt intake decreased the level of rhythmical mineralocorticoid release and elevated rhythmical glucocorticoid release. The projected effect of salt-driven hormone rhythm modulation corresponded well with the measured decrease in water intake and an increase in urine volume with surplus osmolyte excretion. Humans regulate osmolyte and water balance by rhythmical mineralocorticoid and glucocorticoid release, endogenous accrual of surplus body water, and precise surplus excretion. Federal Ministry for Economics and Technology/DLR; the Interdisciplinary Centre for Clinical Research; the NIH; the American Heart Association (AHA); the Renal Research Institute; and the TOYOBO Biotechnology Foundation. Food products were donated by APETITO

  6. Regulations for the peat production water pollution control; Turvetuotannon vesiensuojeluohjeisto

    Energy Technology Data Exchange (ETDEWEB)

    Savolainen, M.; Heikkinen, K.; Ihme, R. [ed.] [VTT Communities and Infrastructure, Espoo (Finland)

    1996-12-31

    The regulations for peat production water pollution control include the latest information on anti-pollution constructions applicable to peat production including field ditches, sedimentation basins, overland flow areas, forest soil saturation, evaporation basins, chemicalization, detention of runoff and artificial flood plains. Information on subsurface drainage in peat mining is also given. The regulations deal with environmental viewpoints, planning of water protection and information on how to build, use and maintain anti-pollution constructions. Special attention is given to the soil conditions, because they play an important role in the building of different constructions. (orig.) (48 refs.)

  7. Regulations for the peat production water pollution control

    International Nuclear Information System (INIS)

    Savolainen, M.; Heikkinen, K.; Ihme, R.

    1996-01-01

    The regulations for peat production water pollution control include the latest information on anti-pollution constructions applicable to peat production including field ditches, sedimentation basins, overland flow areas, forest soil saturation, evaporation basins, chemicalization, detention of runoff and artificial flood plains. Information on subsurface drainage in peat mining is also given. The regulations deal with environmental viewpoints, planning of water protection and information on how to build, use and maintain anti-pollution constructions. Special attention is given to the soil conditions, because they play an important role in the building of different constructions. (orig.) (48 refs.)

  8. Emotion regulation moderates relationships between body image concerns and psychological symptomatology.

    Science.gov (United States)

    Hughes, Elizabeth K; Gullone, Eleonora

    2011-06-01

    The study investigated the moderating role of emotion regulation (ER) in relationships between body image concerns and psychological symptomatology. A community sample of 533 boys and girls (11-20 years) completed measures assessing body image thoughts and feelings, domain-specific and general ER strategies, drive for thinness, and bulimic, depressive and anxiety symptoms. Results indicated that ER moderated relationships between body image concerns and both bulimic and depressive symptoms, but not relationships between body image concerns and drive for thinness or anxiety symptoms. Adolescents who reported frequent body image concerns were more likely to have higher levels of bulimic symptoms if they tended to use avoidance and internal dysfunctional ER strategies. Furthermore, adolescents who reported frequent body image concerns were more likely to have higher levels of depressive symptoms if they used positive rational acceptance and internal functional strategies infrequently. Implications of the findings for prevention and intervention are discussed. Copyright © 2011 Elsevier Ltd. All rights reserved.

  9. Time to revisit arsenic regulations: comparing drinking water and rice.

    Science.gov (United States)

    Sauvé, Sébastien

    2014-05-17

    Current arsenic regulations focus on drinking water without due consideration for dietary uptake and thus seem incoherent with respect to the risks arising from rice consumption. Existing arsenic guidelines are a cost-benefit compromise and, as such, they should be periodically re-evaluated. Literature data was used to compare arsenic exposure from rice consumption relative to exposure arising from drinking water. Standard risk assessment paradigms show that arsenic regulations for drinking water should target a maximum concentration of nearly zero to prevent excessive lung and bladder cancer risks (among others). A feasibility threshold of 3 μg As l(-1) was determined, but a cost-benefit analysis concluded that it would be too expensive to target a threshold below 10 μg As l(-1). Data from the literature was used to compare exposure to arsenic from rice and rice product consumption relative to drinking water consumption. The exposure to arsenic from rice consumption can easily be equivalent to or greater than drinking water exposure that already exceeds standard risks and is based on feasibility and cost-benefit compromises. It must also be emphasized that many may disagree with the implications for their own health given the abnormally high cancer odds expected at the cost-benefit arsenic threshold. Tighter drinking water quality criteria should be implemented to properly protect people from excessive cancer risks. Food safety regulations must be put in place to prevent higher concentrations of arsenic in various drinks than those allowed in drinking water. Arsenic concentrations in rice should be regulated so as to roughly equate the risks and exposure levels observed from drinking water.

  10. Use of tritiated water for estimating body composition in grazing ewes

    International Nuclear Information System (INIS)

    Russel, A.J.F.; Foot, J.Z.; McFarlane, D.M.

    1982-01-01

    Tritiated water was used to estimate total body water, body composition and water turnover of non-pregnant, pregnant, non-lactating and lactating grazing sheep. Body composition was estimated from equilibrated and extrapolated values of tritiated water space. These methods both overestimated the total body water measured directly. Body fat could be predicted satisfactorily from tritiated water space within the physiological states of ewes, i.e. lactating, pregnant, etc., although for lactating ewes the error of prediction is greater. It appears inadvisable at this stage to use equations derived from all classes of ewes to estimate body fat in ewes of any one physiological state. Water turnover varied, with the physiological state being highest for lactating ewes. (author)

  11. P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance.

    Science.gov (United States)

    Loll-Krippleber, Raphael; Brown, Grant W

    2017-09-15

    mRNA-processing (P-) bodies are cytoplasmic granules that form in eukaryotic cells in response to numerous stresses to serve as sites of degradation and storage of mRNAs. Functional P-bodies are critical for the DNA replication stress response in yeast, yet the repertoire of P-body targets and the mechanisms by which P-bodies promote replication stress resistance are unknown. In this study we identify the complete complement of mRNA targets of P-bodies during replication stress induced by hydroxyurea treatment. The key P-body protein Lsm1 controls the abundance of HHT1, ACF4, ARL3, TMA16, RRS1 and YOX1 mRNAs to prevent their toxic accumulation during replication stress. Accumulation of YOX1 mRNA causes aberrant downregulation of a network of genes critical for DNA replication stress resistance and leads to toxic acetaldehyde accumulation. Our data reveal the scope and the targets of regulation by P-body proteins during the DNA replication stress response.P-bodies form in response to stress and act as sites of mRNA storage and degradation. Here the authors identify the mRNA targets of P-bodies during DNA replication stress, and show that P-body proteins act to prevent toxic accumulation of these target transcripts.

  12. Tritium water as a marker for the measurement of body water turnover rates in desert livestock, rodent and bird species

    International Nuclear Information System (INIS)

    Khan, M.S.; Ghosh, P.K.; Bohra, R.C.

    1990-01-01

    Tritiated water has been used for estimating body water turnover rates (BWTRs) in desert livestock, rodent and birds. BWTRs in relation to adaption of these animal species to desert environment have been discussed. (author). 5 refs., 2 tabs

  13. Water requirement and total body water estimation as affected by species, pregnancy and lactation using tritiated water

    International Nuclear Information System (INIS)

    Kamal, T.H.; El Banna, I.M.; Ayad, M.A.; Kotby, E.A.

    1978-01-01

    Radiotracer dilution technique was used to determine total body water (TBW) and the water turnover rate (WTR) estimate of water requirements in water buffaloe, Red Dannish cattle, fat tailed Osemi sheep and Camellus Dromedarius. Water buffaloes were found to have highest TBW, followed by camels, sheep and cattle in a descending order. The WTR ranking was highest for sheep followed by water buffaloe endurance to heat was found inseperable to high water usage, while in camels, an intericate water retention mechanism help animals to thrive in deserts. Fat tailled Osemi sheep and cattle failed to cope with high environmental temperature resulting in temporary dehydration. TBW was 17% and 6% higher in pregnant cattle and sheep than non-pregnant animals respectively, while there was no observed change in pregnant buffaloes. Water retention of pregnant cattle was associated with an appriciable increase in WTR, which was not noticable in buffaloe or sheep. Lactating buffaloe have had a higher TBW and WTR than lactating cattle. Milk yield per day during the period of measurement was higher in buffalo than cattle. Wallowing of buffalo in water pools during grazing, represents a behavioural adaptation for life in hot regions, aside of tendency for higher WTR with concomitant water retention

  14. Hypoxia regulates microRNA expression in the human carotid body

    International Nuclear Information System (INIS)

    Mkrtchian, Souren; Lee, Kian Leong; Kåhlin, Jessica; Ebberyd, Anette; Poellinger, Lorenz; Fagerlund, Malin Jonsson; Eriksson, Lars I.

    2017-01-01

    The carotid body (CB) is the key sensing organ for physiological oxygen levels in the body. Under conditions of low oxygen (hypoxia), the CB plays crucial roles in signaling to the cardiorespiratory center in the medulla oblongata for the restoration of oxygen homeostasis. How hypoxia regulates gene expression in the human CB remains poorly understood. While limited information on transcriptional regulation in animal CBs is available, the identity and impact of important post-transcriptional regulators such as non-coding RNAs, and in particular miRNAs are not known. Here we show using ex vivo experiments that indeed a number of miRNAs are differentially regulated in surgically removed human CB slices when acute hypoxic conditions were applied. Analysis of the hypoxia-regulated miRNAs shows that they target biological pathways with upregulation of functions related to cell proliferation and immune response and downregulation of cell differentiation and cell death functions. Comparative analysis of the human CB miRNAome with the global miRNA expression patterns of a large number of different human tissues showed that the CB miRNAome had a unique profile which reflects its highly specialized functional status. Nevertheless, the human CB miRNAome is most closely related to the miRNA expression pattern of brain tissues indicating that they may have the most similar developmental origins. - Highlights: • Hypoxia triggers differential expression of many miRNAs in the human carotid body. • This can lead to the upregulation of proliferation and immune response functions. • CB expression profile in the carotid body resembles the miRNA expression pattern in the brain. • miRNAs are involved in the regulation of carotid body functions including oxygen sensing.

  15. Hypoxia regulates microRNA expression in the human carotid body

    Energy Technology Data Exchange (ETDEWEB)

    Mkrtchian, Souren, E-mail: souren.mkrtchian@ki.se [Section for Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institute, SE-171 77 Stockholm (Sweden); Lee, Kian Leong, E-mail: csilkl@nus.edu.sg [Cancer Science Institute of Singapore, National University of Singapore, 117599 Singapore (Singapore); Kåhlin, Jessica [Section for Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institute, SE-171 77 Stockholm (Sweden); Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, SE-171 76 Stockholm (Sweden); Ebberyd, Anette [Section for Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institute, SE-171 77 Stockholm (Sweden); Poellinger, Lorenz [Cancer Science Institute of Singapore, National University of Singapore, 117599 Singapore (Singapore); Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm (Sweden); Fagerlund, Malin Jonsson; Eriksson, Lars I. [Section for Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institute, SE-171 77 Stockholm (Sweden); Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, SE-171 76 Stockholm (Sweden)

    2017-03-15

    The carotid body (CB) is the key sensing organ for physiological oxygen levels in the body. Under conditions of low oxygen (hypoxia), the CB plays crucial roles in signaling to the cardiorespiratory center in the medulla oblongata for the restoration of oxygen homeostasis. How hypoxia regulates gene expression in the human CB remains poorly understood. While limited information on transcriptional regulation in animal CBs is available, the identity and impact of important post-transcriptional regulators such as non-coding RNAs, and in particular miRNAs are not known. Here we show using ex vivo experiments that indeed a number of miRNAs are differentially regulated in surgically removed human CB slices when acute hypoxic conditions were applied. Analysis of the hypoxia-regulated miRNAs shows that they target biological pathways with upregulation of functions related to cell proliferation and immune response and downregulation of cell differentiation and cell death functions. Comparative analysis of the human CB miRNAome with the global miRNA expression patterns of a large number of different human tissues showed that the CB miRNAome had a unique profile which reflects its highly specialized functional status. Nevertheless, the human CB miRNAome is most closely related to the miRNA expression pattern of brain tissues indicating that they may have the most similar developmental origins. - Highlights: • Hypoxia triggers differential expression of many miRNAs in the human carotid body. • This can lead to the upregulation of proliferation and immune response functions. • CB expression profile in the carotid body resembles the miRNA expression pattern in the brain. • miRNAs are involved in the regulation of carotid body functions including oxygen sensing.

  16. Estimation of total body water by bioelectrical impedance analysis

    International Nuclear Information System (INIS)

    Kushner, R.F.; Schoeller, D.A.

    1986-01-01

    Total body water (TBW) measured by bioelectrical impedance analysis (BIA) was directly compared with deuterium-isotope dilution in a total of 58 subjects. First, sex-specific and group equations were developed by multiple regression analysis in (10 each) obese and nonobese men and women. Height/resistive impedance was the most significant variable used to predict deuterium-dilution space (D2O-TBW) and, combined with weight, yielded R = 0.99 and SE of estimate = 1.75 L. Equations predicted D2O-TBW equally well for obese and nonobese subjects. Second, the equations were prospectively tested in a heterogeneous group of 6 males and 12 females. Sex-specific equations predicted D2O-TBW with good correlation coefficients (0.96 and 0.93), total error (2.34 and 2.89 L), and a small difference between mean predicted and measured D2O-TBW (-1.4 +/- 2.05 and -0.48 +/- 2.83 L). BIA predicts D2O-TBW more accurately than weight, height, and/or age. A larger population is required to validate the applicability of our equations

  17. 76 FR 6727 - Proposed Amendments to the Water Quality Regulations, Water Code and Comprehensive Plan To...

    Science.gov (United States)

    2011-02-08

    ... location. Written comments will be accepted through the close of business on March 16, 2011. Locations: The... Regulations, Water Code and Comprehensive Plan To Provide for Regulation of Natural Gas Development Projects... proposed rule containing tentative dates and locations for public hearings on proposed amendments to its...

  18. Limit regulation system for pressurized water nuclear reactors

    International Nuclear Information System (INIS)

    Aleite, W.; Bock, H.W.

    1976-01-01

    Described is a limit regulation system for a pressurized water nuclear reactor in combination with a steam generating system connected to a turbine, the nuclear reactor having control rods as well as an operational regulation system and a protective system, which includes reactor power limiting means operatively associated with the control rods for positioning the same and having response values between operating ranges of the operational regulation system, on the one hand, and response values of the protective system, on the other hand, and a live steam-minimal pressure regulation system cooperating with the reactor power limiting means and operatively connected to a steam inlet valve to the turbine for controlling the same

  19. Estrogen receptor-a in medial amygdala neurons regulates body weight

    Science.gov (United States)

    Estrogen receptor–a (ERa) activity in the brain prevents obesity in both males and females. However, the ERa-expressing neural populations that regulate body weight remain to be fully elucidated. Here we showed that single-minded–1 (SIM1) neurons in the medial amygdala (MeA) express abundant levels ...

  20. Macrophages and fibroblasts : key regulators in wound healing, fibrosis and the foreign body reaction

    NARCIS (Netherlands)

    Ploeger, Diana

    2017-01-01

    Macrophages and fibroblasts are key regulators in wound healing, fibrosis and foreign body reaction (FBR). After injury macrophages migrate through the extracellular matrix (ECM) towards the wounded area, and adopt a M1 or M2 phenotype. M1 macrophages are associated with tissue injury and

  1. Environmental light and suprachiasmatic nucleus interact in the regulation of body temperature.

    NARCIS (Netherlands)

    Scheer, F.A.J.L.; Pirovano, C.; Someren, E.J.W. van; Buijs, R.M.

    2005-01-01

    The mammalian biological clock, located in the suprachiasmatic nucleus (SCN), is crucial for circadian rhythms in physiology and behavior. However, equivocal findings have been reported on its role in the circadian regulation of body temperature. The goal of the present studies was to investigate

  2. Development of fauna of water beetles (Coleoptera in waters bodies of a river valley – habitat factors, landscape and geomorphology

    Directory of Open Access Journals (Sweden)

    Pakulnicka Joanna

    2016-01-01

    Full Text Available The goal of the study was to identify the beetle fauna of a small lowland river valley against its spatial arrangement and the directions of beetle migrations between habitats, as well as to determine which environmental factors affect the characteristics of water beetle populations in a river valley's lentic water bodies. The field studies were carried out in various types of water bodies. 112 species of beetles with various ecological characteristics were identified. It was demonstrated that the diversity of water bodies in the valley is conducive to high local species richness. At the same time, the observed high degree of faunistic individualism may be regarded as a sign of poor symmetry in the directions of fauna propagation, particularly that of stagnobionts. The authors argue that high individualism is the consequence of poor hydrological contact between the water bodies due to topography and rare instances of high tide in the river, which, in turn, is the reason for active overflights remaining the main mean of migration between those water bodies. The factors restricting migration of fauna between the water bodies include certain landscape characteristics of the catchment which form topographical obstacles, mainly numerous and dense forest areas. The character of fauna in the respective types of water bodies is affected also by internal environmental factors, particularly the degree to which they are overgrown with macrophytes, type of bottom, type of mineral and organic matter as well as physical parameters of water, such as saturation, pH, temperature and biological oxygen demand.

  3. Harmful effects of wastewater disposal into water bodies: a case ...

    African Journals Online (AJOL)

    Improper disposal of waste water and the problems of addressing ... Abattoir wastes, industrial wastes from breweries, agricultural runoffs, and waste water from ... Ni and Pb make such water unsuitable for drinking, irrigation, aquatic life and ...

  4. Eutrophication and cyanobacteria in South Africa’s standing water bodies: A view from space

    CSIR Research Space (South Africa)

    Matthews, MW

    2015-05-01

    Full Text Available Satellite remote sensing can make a significant contribution to monitoring water quality in South African standing water bodies. Eutrophication, defined as enrichment by nutrients, and toxin-producing cyanobacteria (blue-green algae) blooms pose a...

  5. The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size.

    Science.gov (United States)

    Rideout, Elizabeth J; Narsaiya, Marcus S; Grewal, Savraj S

    2015-12-01

    Almost all animals show sex differences in body size. For example, in Drosophila, females are larger than males. Although Drosophila is widely used as a model to study growth, the mechanisms underlying this male-female difference in size remain unclear. Here, we describe a novel role for the sex determination gene transformer (tra) in promoting female body growth. Normally, Tra is expressed only in females. We find that loss of Tra in female larvae decreases body size, while ectopic Tra expression in males increases body size. Although we find that Tra exerts autonomous effects on cell size, we also discovered that Tra expression in the fat body augments female body size in a non cell-autonomous manner. These effects of Tra do not require its only known targets doublesex and fruitless. Instead, Tra expression in the female fat body promotes growth by stimulating the secretion of insulin-like peptides from insulin producing cells in the brain. Our data suggest a model of sex-specific growth in which body size is regulated by a previously unrecognized branch of the sex determination pathway, and identify Tra as a novel link between sex and the conserved insulin signaling pathway.

  6. The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size.

    Directory of Open Access Journals (Sweden)

    Elizabeth J Rideout

    2015-12-01

    Full Text Available Almost all animals show sex differences in body size. For example, in Drosophila, females are larger than males. Although Drosophila is widely used as a model to study growth, the mechanisms underlying this male-female difference in size remain unclear. Here, we describe a novel role for the sex determination gene transformer (tra in promoting female body growth. Normally, Tra is expressed only in females. We find that loss of Tra in female larvae decreases body size, while ectopic Tra expression in males increases body size. Although we find that Tra exerts autonomous effects on cell size, we also discovered that Tra expression in the fat body augments female body size in a non cell-autonomous manner. These effects of Tra do not require its only known targets doublesex and fruitless. Instead, Tra expression in the female fat body promotes growth by stimulating the secretion of insulin-like peptides from insulin producing cells in the brain. Our data suggest a model of sex-specific growth in which body size is regulated by a previously unrecognized branch of the sex determination pathway, and identify Tra as a novel link between sex and the conserved insulin signaling pathway.

  7. A scheme for regulating toxic substances to water quality of Chamsil upstream water system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kang Suk; Kim, Jee Hoon [Korea Environment Institute, Seoul (Korea)

    1998-12-01

    This study asserts to reflect a concept of toxicity thoroughly in the present water quality concept. It presents an appropriate solution to control toxic substances flowing into the Chamsil upstream water system. Although a regulation of toxic substances into major rivers in Korea other than Han river is also required urgently, it will be studied in future. It is expected that this study on Chamsil upstream would be a cornerstone for establishing a national regulation policy of toxic substances into water system. 28 refs., 1 fig., 36 tabs.

  8. Water turnover rate and total body water affected by different physiological factors under Egyptian environmental conditions

    International Nuclear Information System (INIS)

    Kamal, T.H.

    1982-01-01

    The tritiated water dilution technique was used to determine the total body water (TBW) and water turnover rate (WTR), which is assumed to be similar to water intake, in water buffalo, Red Danish cattle, fat-tailed Osemi sheep and crossed Nubian-Bedouin goats and camels (Camelus dromedarius). There was a significant (P < 0.05) effect of species on TBW and WTR. The combined data of buffalo, cattle and sheep revealed a significant (P < 0.05) effect of pregnancy on TBW, but not on WTR. The combined data of buffalo and cattle showed a significantly lower TBW (P < 0.01) and a higher WTR (P < 0.05) in lactating animals than in heifers. In buffalo WTR was on average 81% higher in summer grazing (SG) than in spring. It was also 118 and 20% higher in summer non-grazing (SNG), than in either spring or SG, respectively. The differences between treatments in heifers, pregnant and lactating, were significant (P<0.01), except between spring and SG in heifers. The TBW was on average 12% higher in SG than in spring. It was also 18 and 5% higher in SNG than in either spring or SG, respectively. The differences between treatments in heifers, pregnant and lactating, were significant, except between SG and SNG in heifers and lactating cows and between spring and SG in lactating cows. (author)

  9. A new approach to inventorying bodies of water, from local to global scale

    Directory of Open Access Journals (Sweden)

    Bartout, Pascal

    2015-12-01

    Full Text Available Having reliable estimates of the number of water bodies on different geographical scales is of great importance to better understand biogeochemical cycles and to tackle the social issues related to the economic and cultural use of water bodies. However, limnological research suffers from a lack of reliable inventories; the available scientific references are predominately based on water bodies of natural origin, large in size and preferentially located in previously glaciated areas. Artificial, small and randomly distributed water bodies, especially ponds, are usually not inventoried. Following Wetzel’s theory (1990, some authors included them in global inventories by using remote sensing or mathematical extrapolation, but fieldwork on the ground has been done on a very limited amount of territory. These studies have resulted in an explosive increase in the estimated number of water bodies, going from 8.44 million lakes (Meybeck 1995 to 3.5 billion water bodies (Downing 2010. These numbers raise several questions, especially about the methodology used for counting small-sized water bodies and the methodological treatment of spatial variables. In this study, we use inventories of water bodies for Sweden, Finland, Estonia and France to show incoherencies generated by the “global to local” approach. We demonstrate that one universal relationship does not suffice for generating the regional or global inventories of water bodies because local conditions vary greatly from one region to another and cannot be offset adequately by each other. The current paradigm for global estimates of water bodies in limnology, which is based on one representative model applied to different territories, does not produce sufficiently exact global inventories. The step-wise progression from the local to the global scale requires the development of many regional equations based on fieldwork; a specific equation that adequately reflects the actual relationship

  10. The Role of Adaptation in Body Load-Regulating Mechanisms During Locomotion

    Science.gov (United States)

    Ruttley, Tara; Holt, Christopher; Mulavara, Ajitkumar; Bloomberg, Jacob

    2010-01-01

    Body loading is a fundamental parameter that modulates motor output during locomotion, and is especially important for controlling the generation of stepping patterns, dynamic balance, and termination of locomotion. Load receptors that regulate and control posture and stance in locomotion include the Golgi tendon organs and muscle spindles at the hip, knee, and ankle joints, and the Ruffini endings and the Pacinian corpuscles in the soles of the feet. Increased body weight support (BWS) during locomotion results in an immediate reorganization of locomotor control, such as a reduction in stance and double support duration and decreased hip, ankle, and knee angles during the gait cycle. Previous studies on the effect during exposure to increased BWS while walking showed a reduction in lower limb joint angles and gait cycle timing that represents a reorganization of locomotor control. Until now, no studies have investigated how locomotor control responds after a period of exposure to adaptive modification in the body load sensing system. The goal of this research was to determine the adaptive properties of body load-regulating mechanisms in locomotor control during locomotion. We hypothesized that body load-regulating mechanisms contribute to locomotor control, and adaptive changes in these load-regulating mechanisms require reorganization to maintain forward locomotion. Head-torso coordination, lower limb movement patterns, and gait cycle timing were evaluated before and after a 30-minute adaptation session during which subjects walked on a treadmill at 5.4 km/hr with 40% body weight support (BWS). Before and after the adaptation period, head-torso and lower limb 3D kinematic data were obtained while performing a goal directed task during locomotion with 0% BWS using a video-based motion analysis system, and gait cycle timing parameters were collected by foot switches positioned under the heel and toe of the subjects shoes. Subjects showed adaptive modification in

  11. 75 FR 38710 - Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY

    Science.gov (United States)

    2010-07-06

    ...-AA08 Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY AGENCY: Coast... Regulation on the navigable waters of Huntington Bay, New York due to the annual Fran Schnarr Open Water... ``Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY'' in the Federal...

  12. Energy Density, Energy Intake, and Body Weight Regulation in Adults12345

    Science.gov (United States)

    Karl, J. Philip; Roberts, Susan B.

    2014-01-01

    The role of dietary energy density (ED) in the regulation of energy intake (EI) is controversial. Methodologically, there is also debate about whether beverages should be included in dietary ED calculations. To address these issues, studies examining the effects of ED on EI or body weight in nonelderly adults were reviewed. Different approaches to calculating dietary ED do not appear to alter the direction of reported relations between ED and body weight. Evidence that lowering dietary ED reduces EI in short-term studies is convincing, but there are currently insufficient data to determine long-term effectiveness for weight loss. The review also identified key barriers to progress in understanding the role of ED in energy regulation, in particular the absence of a standard definition of ED, and the lack of data from multiple long-term clinical trials examining the effectiveness of low-ED diet recommendations for preventing both primary weight gain and weight regain in nonobese individuals. Long-term clinical trials designed to examine the impact of dietary ED on energy regulation, and including multiple ED calculation methods within the same study, are still needed to determine the importance of ED in the regulation of EI and body weight. PMID:25398750

  13. Chironomidae (Diptera, Chironomidae) as biological indicators of water bodies ecological condition

    International Nuclear Information System (INIS)

    Bakhtin, M.M.; Sejsebaev, A.T.

    2002-01-01

    The paper presents data confirming that Chironomidae are good to be used as an indicative criterion when classifying lakes. It was found that their quantity and presence of certain species could serve as an index in assessment of water body ecological condition. Results of cytotaxonomic analysis helped to reveal the nature of Chironomini species diversity in STS water bodies. (author)

  14. Regulation of Caenorhabditis elegans body size and male tail development by the novel gene lon-8

    Directory of Open Access Journals (Sweden)

    Korswagen Hendrik C

    2007-03-01

    Full Text Available Abstract Background In C. elegans and other nematode species, body size is determined by the composition of the extracellular cuticle as well as by the nuclear DNA content of the underlying hypodermis. Mutants that are defective in these processes can exhibit either a short or a long body size phenotype. Several mutations that give a long body size (Lon phenotype have been characterized and found to be regulated by the DBL-1/TGF-β pathway, that controls post-embryonic growth and male tail development. Results Here we characterize a novel gene affecting body size. lon-8 encodes a secreted product of the hypodermis that is highly conserved in Rhabditid nematodes. lon-8 regulates larval elongation as well as male tail development. In both processes, lon-8 appears to function independently of the Sma/Mab pathway. Rather, lon-8 genetically interacts with dpy-11 and dpy-18, which encode cuticle collagen modifying enzymes. Conclusion The novel gene lon-8 encodes a secreted product of the hypodermis that controls body size and male ray morphology in C. elegans. lon-8 genetically interacts with enzymes that affect the composition of the cuticle.

  15. CARACTERISTICS OF THE LOWER DANUBE WATER BODIES BETWEEN PORTILE DE FIER

    Directory of Open Access Journals (Sweden)

    Elena ŢUCHIU

    2010-12-01

    Full Text Available The main goal of the Water Framework Directive (2000/60/EC Directive is the achievement of the “good status” of the water bodies, environmental objective which can be reached through elaboration and implementation of the River Basin Management Plan. According to the legal requirements, at the 22nd of December 2009, Romania has elaborated the first National Management Plan – synthesis of the River Basin Management Plans. This process assumes the types identification and water bodies delineation on the basis of some abiotic and biotic parameters, such: water category, abiotic and biotic typology, physical features, water status, pressures and their impacts, as well as protected areas. Therefore, for the lower Danube sector between Bazias and Isaccea 4 water bodies have been delineated: 2 reservoirs (Portile de Fier/Iron Gates and Ostrov and 2 river sectors (Ostrov – Chiciu, Chiciu – Isaccea. The procedure for assessment of the environmental objectives risk failing (on the basis of pressures and impacts has shown that all 4 water bodies have been identified at risk from the point of view of organic substances, nutrients, hazardous substances and hydro-morphological alterations. The Water Framework Directive defines the surface water status through: the ecological status - 5 classes (based on biological, hydro-morphological and physic-chemical elements and chemical status – 2 classes (based on priority substances. In present, the 4 water bodies identified on the lower Danube sector do not reach the good status, being designated as heavily modified water bodies.

  16. COMMERCIAL FISH HARVEST IN INLAND WATER BODIES OF GERMANY (A REVIEW

    Directory of Open Access Journals (Sweden)

    А. Didenko

    2016-10-01

    Full Text Available Purpose. To analyze scientific and statistical sources on commercial fishery in inland water bodies of Germany. To summarize German experience and identify specific features of this sector. Findings. Commercial fishery in Germany is carried out on 30% (≈250 000 hectares of inland water bodies of Germany. The main fishing regions are prealpine lakes in Bavaria, Lake Constance, lakes in Schleswig-Holstein, Mecklenburg-Western Pomerania federal states as well as lakes and rivers of Brandenburg and Berlin. Commercial fishing on rivers usually has a local importance and is practiced in regions with poorly developed industry. There were 670 commercial fishing organizations in 2014, where 932 people were employed. Each fishing license owner is allowed deploying simultaneously a clearly defined number of fishing gears depending on season. In addition, fishing nets are regulated not only based on their mesh size and length, but also height and the minimum thread diameter. The cardinal difference of German inland fishing is the absence of the periods of total ban on commercial fishing. There are only ban periods for fishing on certain fish species during their spawning seasons. These periods differ for federal states and are listed in the relevant regional fishing rules. The total fish catch in inland waters of Germany by commercial fishermen in 2014 was 3132 tons, much lower than the catches of anglers who caught 18 450 tons at the same year. Most of fish were caught by fishing organizations in the Brandenburg Federal State. Average fish productivity in 2014 was approx. 13 kg/ha (ranging from 10 to 20 kg/ha. Whitefish was the dominant species in catches in the Lake Constance and prealpine lakes of Bavaria, while cyprinids (roach, bream, silver bream, blue bream, etc. dominated in Northern Germany. The profit of commercial fish catch in 2014 was about 12.5 million euros. Among numerous activities aimed at preserving commercial fish populations, Germans

  17. Productivity growth and price regulation of Slovenian water distribution utilities

    Directory of Open Access Journals (Sweden)

    Jelena Zorić

    2010-06-01

    Full Text Available This paper aims to analyse the price regulation method and performance of thewater industry in Slovenia. A stochastic cost frontier model is employed to estimate and decompose the total factor productivity (TFP growth of water distribution utilities in the 1997-2003 period. The main goal is to find out whether the lack of proper incentives to improve performance has resulted in the low TFP growth of Slovenian water distribution utilities. The evidence suggests that cost inefficiencies are present in water utilities, which indicates considerable cost saving potential in the analysed industry. Technical change is found to have positively affected the TFP growth over time, while cost inefficiency levels remained essentially unchanged. Overall, the average annual TFP growth in the analysed period is estimated to be only slightly above zero, which is a relatively poor result. This can largely be contributed to the present institutional and regulatory setting that does not stimulate utilities to improve productivity. Therefore, the introduction of an independent regulatory agency and an incentive-based price regulation scheme should be seriously considered in order to enhance the performance of Slovenian water distribution utilities.

  18. Quantification of surface energy fluxes from a small water body using scintillometry and eddy covariance

    DEFF Research Database (Denmark)

    McGloin, Ryan; McGowan, Hamish; McJannet, David

    2014-01-01

    Accurate quantification of evaporation from small water storages is essential for water management and planning, particularly in water-scarce regions. In order to ascertain suitable methods for direct measurement of evaporation from small water bodies, this study presents a comparison of eddy......% greater than eddy covariance measurements. We suggest possible reasons for this difference and provide recommendations for further research for improving measurements of surface energy fluxes over small water bodies using eddy covariance and scintillometry. Key Points Source areas for Eddy covariance...... and scintillometry were on the water surface Reasonable agreement was shown between the sensible heat flux measurements Scintillometer estimates of latent heat flux were greater than eddy covariance...

  19. The precautionary principle in environmental regulations for drinking water

    International Nuclear Information System (INIS)

    Crawford-Brown, Douglas; Crawford-Brown, Sean

    2011-01-01

    The precautionary principle has been proposed as a means of providing increased safety for consumers of drinking water. While the principle has received increased attention over the past 2 decades, it remains rather poorly defined both in law and practice. Hence, the implications for application in risk-based decisions on water quality are not fully developed. This paper examines a series of philosophical, practical and decision-theoretic issues related to the application of the principle in such decisions, highlighting areas where at least the intent of the principle is already well embedded in environmental regulation through margins of safety, and identifying residual issues. A conclusion is drawn that full application of the principle may be driven forward both by programmes such as REACH in the EU, and by the emerging Water Framework Directive and multi-stakeholder approaches to climate change mitigation and adaptation.

  20. [Remote sensing monitoring and screening for urban black and odorous water body: A review.

    Science.gov (United States)

    Shen, Qian; Zhu, Li; Cao, Hong Ye

    2017-10-01

    Continuous improvement of urban water environment and overall control of black and odorous water body are not merely national strategic needs with the action plan for prevention and treatment of water pollution, but also the hot issues attracting the attention of people. Most previous researches concentrated on the study of cause, evaluation and treatment measures of this phenomenon, and there are few researches on the monitoring using remote sensing, which is often a strain to meet the national needs of operational monitoring. This paper mainly summarized the urgent research problems, mainly including the identification and classification standard, research on the key technologies, and the frame of remote sensing screening systems for the urban black and odorous water body. The main key technologies were concluded too, including the high spatial resolution image preprocessing and extraction technique for black and odorous water body, the extraction of water information in city zones, the classification of the black and odorous water, and the identification and classification technique based on satellite-sky-ground remote sensing. This paper summarized the research progress and put forward research ideas of monitoring and screening urban black and odorous water body via high spatial resolution remote sensing technology, which would be beneficial to having an overall grasp of spatial distribution and improvement progress of black and odorous water body, and provide strong technical support for controlling urban black and odorous water body.

  1. Overview of the current National Primary Drinking Water Regulations and regulation development process

    International Nuclear Information System (INIS)

    Cotruvo, J.A.; Regelski, M.

    1989-01-01

    The promulgation of the National Primary Drinking Water Regulations (NPDWR) follows specific steps. First, the Advance Notice of Proposed Rule Making (ANPRM) is published. Second, the EPA, as mandated by the SDWA Amendments, proposes maximum contaminant levels (MCLs), (enforceable standards) and maximum contaminant level goals (MCLGs) simultaneously. The Office of Drinking Water developed a six-phase schedule that has attempted to parallel the SDWA-specified deadlines: Phase I - Voltile organic chemicals - July 8, 1987; Phase II - Synthetic organic chemicals and inorganic chemicals - June 1989, microbials and surface water treatment - June 1989, and Lead/copper - December 1988; Phase III - Radionuclides - December 1988; Phase IV - Disinfectants and disinfection by-products - June 1989; Phase V - Other inorganic chemicals, synthetic organic chemicals, and pesticides - June 1989; and Phase VI - 25 additional chemicals - January 199. In selecting contaminants for regulation, the most relevant criteria are (1) potential health risk; (2) ability to detect a contaminant in the drinking water; and (3) occurrence or potential occurrence in drinking water. The EPA uses a three category approach for setting maximum contaminant level goals for carcinogens: Category I, strong evidence of carcinogenicity-zero; Category II, equivocal evidence - reference dose (RfD) approach or 0.00001 to 0.000001 cancer risk range; and Category III, inadequate or no evidence from animal studies - RfD approach. 10 refs., 5 tabs

  2. METHODS OF ESTIMATION TECHNOGENIC POLLUTION OF WATER BODIES IN URBANIZED TERRITORIES

    Directory of Open Access Journals (Sweden)

    Kurochkina Valentina Aleksandrovna

    2016-06-01

    Full Text Available In the article the authors consider the problem of the impact of man-caused load on river hydraulics processes and on the properties of river sediments that determine river channels evolution and general ecological state of water bodies. The interrelation between ecological state of water bodies, the quality of water in them and the level of contamination of sediments was determined. It is established that the conditions of long-term aquatic life as a whole and of water quality in particular directly depend on the contamination level of sediments. It is shown that the rate and volume of sediments accumulation, as well as contamination level of sediment layers, vary throughout the lifecycle of water body, which allows using sediments as the main indicator of the ecological state of water body reflecting the level of technogenic impact on aquatic ecosystems.

  3. Eutrophication and cyanobacteria in South Africa's standing water bodies: A view from space

    OpenAIRE

    Matthews, Mark W.; Bernard, Stewart

    2015-01-01

    Satellite remote sensing can make a significant contribution to monitoring water quality in South African standing water bodies. Eutrophication, defined as enrichment by nutrients, and toxin-producing cyanobacteria (blue-green algae) blooms pose a significant threat to the quality of South African surface water bodies. The status and trends of chlorophyll a (chl-a, a proxy for eutrophication), cyanobacterial blooms and cyanobacterial surface scum were determined for South Africa’s 50 largest ...

  4. Body weight regulation and obesity: dietary strategies to improve the metabolic profile.

    Science.gov (United States)

    Munsters, M J M; Saris, W H M

    2014-01-01

    This review discusses dietary strategies that may improve the metabolic profile and body weight regulation in obesity. Recent evidence demonstrated that long-term health effects seem to be more beneficial for low-glycemic index (GI) diets compared to high-protein diets. Still, these results need to be confirmed by other prospective cohort studies and long-term clinical trials, and the discrepancy between these study designs needs to be explored in more detail. Furthermore, the current literature is mixed with regard to the efficacy of increased meal frequency (or snacking) regimens in causing metabolic alterations, particularly in relation to body weight control. In conclusion, a growing body of evidence suggests that dietary strategies with the aim to reduce postprandial insulin response and increase fat oxidation, and that tend to restore metabolic flexibility, have a place in the prevention and treatment of obesity and associated metabolic disorders.

  5. Contributions of the Hippocampus and Medial Prefrontal Cortex to Energy and Body Weight Regulation

    Science.gov (United States)

    Davidson, T. L.; Chan, Kinho; Jarrard, Leonard E.; Kanoski, Scott E.; Clegg, Deborah J.; Benoit, Stephen C.

    2008-01-01

    The effects of selective ibotenate lesions of the complete hippocampus (CHip), the hippocampal ventral pole (VP), or the medial prefrontal cortex (mPFC) in male rats were assessed on several measures related to energy regulation (i.e., body weight gain, food intake, body adiposity, metabolic activity general behavioral activity, conditioned appetitive responding). The testing conditions were designed to minimize the nonspecific debilitating effects of these surgeries on intake and body weight. Rats with CHip and VP lesions exhibited significantly greater weight gain and food intake compared to controls. Furthermore, CHip-lesioned rats, but not rats with VP lesions, showed elevated metabolic activity, general activity in the dark phase of the light-dark cycle, and greater conditioned appetitive behavior, compared to control rats without these brain lesions. In contrast, rats with mPFC lesions were not different from controls on any of these measures. These results indicate that hippocampal damage interferes with energy and body weight regulation, perhaps by disrupting higher-order learning and memory processes that contribute to the control of appetitive and consummatory behavior. PMID:18831000

  6. Regulatory body core competencies: when should a regulator contract a TSO?

    International Nuclear Information System (INIS)

    Wieland, Patricia; Salati de Almeida, Ivan P.; Almeida, Claudio U.; Costa, Eduardo M.

    2008-01-01

    The main nuclear regulatory functions are authorization, safety review and assessment, inspection and enforcement and development of regulations and guides. Additionally, the following supplementary functions may be executed by the regulatory body: research and development, emergency response and international cooperation. In order to function properly, the regulatory body should also have the following support functions: general management, logistics, training, communication and information, information technology support, institutional relationship, internal controls and audits, ombudsman and legal support. Technical Support Organizations (TSOs) may assist the regulatory body in meeting the challenges in a rapid growing and changing environment. Specially when there is a temporary need for a wider technical expertise diversity, short time to finish a project or when the cost of developing and maintaining infrastructure of their own laboratories for analysis and research is too high and may deviate the focus on the regulator's mission. Decision on the 'size' of the regulatory body and on what can be contracted to a Technical Support Organization (TSO) depends on the resources and capabilities needed to fulfil the regulatory functions efficiently. It is important to establish the core competencies that must be at the regulatory body, keeping the focus on the regulatory goals and define the real need to contract a TSO, weighting the benefits and disadvantages. As a contribution to the definition of the regulatory core competencies, the paper discusses what is essential to be kept at the regulatory body and what can be delegated to a TSO; how to manage and control the work of the TSO; the cost effectiveness of contracting, sharing of tacit knowledge; how to handle eventual conflicts between the parties involved in the licensing process; contract types and risk evaluation, concerning the dependence on a TSO, eventual change of partners and the intellectual capital

  7. Differential Effects of Two Fermentable Carbohydrates on Central Appetite Regulation and Body Composition

    Science.gov (United States)

    Gibson, Glenn R.; Tuohy, Kieran M.; Sharma, Raj Kumar; Swann, Jonathan R.; Deaville, Eddie R.; Sleeth, Michele L.; Thomas, E. Louise; Holmes, Elaine; Bell, Jimmy D.; Frost, Gary

    2012-01-01

    Background Obesity is rising at an alarming rate globally. Different fermentable carbohydrates have been shown to reduce obesity. The aim of the present study was to investigate if two different fermentable carbohydrates (inulin and β-glucan) exert similar effects on body composition and central appetite regulation in high fat fed mice. Methodology/Principal Findings Thirty six C57BL/6 male mice were randomized and maintained for 8 weeks on a high fat diet containing 0% (w/w) fermentable carbohydrate, 10% (w/w) inulin or 10% (w/w) β-glucan individually. Fecal and cecal microbial changes were measured using fluorescent in situ hybridization, fecal metabolic profiling was obtained by proton nuclear magnetic resonance (1H NMR), colonic short chain fatty acids were measured by gas chromatography, body composition and hypothalamic neuronal activation were measured using magnetic resonance imaging (MRI) and manganese enhanced MRI (MEMRI), respectively, PYY (peptide YY) concentration was determined by radioimmunoassay, adipocyte cell size and number were also measured. Both inulin and β-glucan fed groups revealed significantly lower cumulative body weight gain compared with high fat controls. Energy intake was significantly lower in β-glucan than inulin fed mice, with the latter having the greatest effect on total adipose tissue content. Both groups also showed an increase in the numbers of Bifidobacterium and Lactobacillus-Enterococcus in cecal contents as well as feces. β- glucan appeared to have marked effects on suppressing MEMRI associated neuronal signals in the arcuate nucleus, ventromedial hypothalamus, paraventricular nucleus, periventricular nucleus and the nucleus of the tractus solitarius, suggesting a satiated state. Conclusions/Significance Although both fermentable carbohydrates are protective against increased body weight gain, the lower body fat content induced by inulin may be metabolically advantageous. β-glucan appears to suppress neuronal

  8. Differential effects of two fermentable carbohydrates on central appetite regulation and body composition.

    Directory of Open Access Journals (Sweden)

    Tulika Arora

    Full Text Available Obesity is rising at an alarming rate globally. Different fermentable carbohydrates have been shown to reduce obesity. The aim of the present study was to investigate if two different fermentable carbohydrates (inulin and β-glucan exert similar effects on body composition and central appetite regulation in high fat fed mice.Thirty six C57BL/6 male mice were randomized and maintained for 8 weeks on a high fat diet containing 0% (w/w fermentable carbohydrate, 10% (w/w inulin or 10% (w/w β-glucan individually. Fecal and cecal microbial changes were measured using fluorescent in situ hybridization, fecal metabolic profiling was obtained by proton nuclear magnetic resonance ((1H NMR, colonic short chain fatty acids were measured by gas chromatography, body composition and hypothalamic neuronal activation were measured using magnetic resonance imaging (MRI and manganese enhanced MRI (MEMRI, respectively, PYY (peptide YY concentration was determined by radioimmunoassay, adipocyte cell size and number were also measured. Both inulin and β-glucan fed groups revealed significantly lower cumulative body weight gain compared with high fat controls. Energy intake was significantly lower in β-glucan than inulin fed mice, with the latter having the greatest effect on total adipose tissue content. Both groups also showed an increase in the numbers of Bifidobacterium and Lactobacillus-Enterococcus in cecal contents as well as feces. β-Glucan appeared to have marked effects on suppressing MEMRI associated neuronal signals in the arcuate nucleus, ventromedial hypothalamus, paraventricular nucleus, periventricular nucleus and the nucleus of the tractus solitarius, suggesting a satiated state.Although both fermentable carbohydrates are protective against increased body weight gain, the lower body fat content induced by inulin may be metabolically advantageous. β-Glucan appears to suppress neuronal activity in the hypothalamic appetite centers. Differential

  9. Bioimpedance measurement of body water correlates with measured volume balance in injured patients.

    Science.gov (United States)

    Rosemurgy, A S; Rodriguez, E; Hart, M B; Kurto, H Z; Albrink, M H

    1993-06-01

    Bioimpedance technology is being used increasingly to determine drug volume of distribution, body water status, and nutrition repletion. Its accuracy in patients experiencing large volume flux is not established. To address this, we undertook this prospective study in 54 consecutive seriously injured adults who had emergency celiotomy soon after arrival in the emergency department. Bioimpedance measurements were obtained in the emergency department before the patient was transported to the operating room, on completion of celiotomy, and 24 hours and 48 hours after celiotomy. Bioimpedance measurements of body water were compared with measured fluid balance. If insensible losses are subtracted from measured fluid balance, the percentage of body weight, which is body water determined by bioimpedance, closely follows fluid flux. This study supports the use of bioimpedance measurements in determining total body water even during periods of surgery, blood loss, and vigorous resuscitation.

  10. Warts signaling controls organ and body growth through regulation of ecdysone

    DEFF Research Database (Denmark)

    Møller, Morten Erik; Nagy, Stanislav; Gerlach, Stephan Uwe

    2017-01-01

    Coordination of growth between individual organs and the whole body is essential during development to produce adults with appropriate size and proportions [1, 2]. How local organ-intrinsic signals and nutrient-dependent systemic factors are integrated to generate correctly proportioned organisms...... under different environmental conditions is poorly understood. In Drosophila, Hippo/Warts signaling functions intrinsically to regulate tissue growth and organ size [3, 4], whereas systemic growth is controlled via antagonistic interactions of the steroid hormone ecdysone and nutrient-dependent insulin....../insulin-like growth factor (IGF) (insulin) signaling [2, 5]. The interplay between insulin and ecdysone signaling regulates systemic growth and controls organismal size. Here, we show that Warts (Wts; LATS1/2) signaling regulates systemic growth in Drosophila by activating basal ecdysone production, which negatively...

  11. Heavy metals concentrations in water bodies around aquamarine ...

    African Journals Online (AJOL)

    Water samples from three streams in the mining area of Eggon Hill were analysed. The Physicochemical values obtained were compared with WHO permissible standards in drinking water. Except for Cu and Zn with levels within permissible limits, other heavy metals determined were found to have levels above the WHO ...

  12. Optimum operation of restoration techniques for eutrophic water bodies

    Science.gov (United States)

    Hagen, N. M.; Kleeberg, H.-B.

    1994-05-01

    Operating rules have been applied in water resources management for a long time in order to control and supply a required quantity (volume) of water. The operating rules have to guarantee the optimum management of the reservoir(s). The quality of the stored water has been satisfactory for the desired utilization up to the sixties. Due to the deterioration of reservoir water quality through human impacts, however, increased attention had to be paid since. Eutrophication of stagnant waters is still an unsolved problem. Through means of various restoration techniques, i.e., dilution/flushing or hypolimnetic withdrawal, the quality of the stored water can be improved. Continuous operation or appropriate time or depth variant operating rules are required to achieve this goal. The paper presents such rules for long-term operation. They have been established for the first time and can he represented in two or three-dimensional graphs depending on the number of included components (e.g., actual water storage and quality). The ‘quality operating rules’ take into account the dynamics of the processes in aquatic ecosystems. Simplifications with regard to application and acceptance (e.g., clarity) are developed and tested. The general validity and efficiency of the operating rules have been proved in a case study (a multi-purpose reservoir) and a fictitious lake.

  13. Isotope hydrogeochemical characteristics of water bodies in Munigou, Sichuan

    International Nuclear Information System (INIS)

    Li Hongye; Yin Guan; Yang Junyi; Fan Xiao

    2003-01-01

    Munigou is a part of Huanglong -Jiuzhaigou national scenic in northern Sichuan province. By using isotope geochemistry technique of natural water to analyze the data of δ D, δ 18 O, tritium contents, deuterium excess parameters (d-excess) and element chemical analyses, we discusses the recharge, runoff, discharge and hydraulic relationship between the precipitation, terrain surface water, groundwater and main spring in the Munigou area. Pearl spring and Jadeite spring are major spring resources in this spot. Pearl spring is a hot spring that recharged by the precipitation that sourced from an elevation of more than 3700 m. The part of precipitation infiltrate underground and return the earth's surface after it exchanged quantity of heat with deep hot fluid. So the Pearl spring can be exploited as hot spring; The Jadeite spring is typical acidic karst water cold spring. The velocity of flow of the water in the Jadeite spring's aquifer is slower than the Pearl spring's and the water has long detained time. The spring water has a good quality and important economical value for natural mineral water; Most of runoff in Munigou recharged by precipitation and shallow groundwater. This recharge have seasonal variation and important for scenic spot. These discussed problems in article have far-reaching meaning on evaluation the exploited potential of the Pearl spring and Jadeite spring and is important to protecting and developing the precious natural resource in Munigou area. And provides reference for the similar researches too. (authors)

  14. Novel energy-saving strategies to multiple stressors in birds: the ultradian regulation of body temperature.

    Science.gov (United States)

    Tattersall, Glenn J; Roussel, Damien; Voituron, Yann; Teulier, Loïc

    2016-09-28

    This study aimed to examine thermoregulatory responses in birds facing two commonly experienced stressors, cold and fasting. Logging devices allowing long-term and precise access to internal body temperature were placed within the gizzards of ducklings acclimated to cold (CA) (5°C) or thermoneutrality (TN) (25°C). The animals were then examined under three equal 4-day periods: ad libitum feeding, fasting and re-feeding. Through the analysis of daily as well as short-term, or ultradian, variations of body temperature, we showed that while ducklings at TN show only a modest decline in daily thermoregulatory parameters when fasted, they exhibit reduced surface temperatures from key sites of vascular heat exchange during fasting. The CA birds, on the other hand, significantly reduced their short-term variations of body temperature while increasing long-term variability when fasting. This phenomenon would allow the CA birds to reduce the energetic cost of body temperature maintenance under fasting. By analysing ultradian regulation of body temperature, we describe a means by which an endotherm appears to lower thermoregulatory costs in response to the combined stressors of cold and fasting. © 2016 The Author(s).

  15. Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium.

    Directory of Open Access Journals (Sweden)

    Narendranath Reddy Chintagari

    2010-02-01

    Full Text Available Lung surfactant reduces surface tension and maintains the stability of alveoli. How surfactant is released from alveolar epithelial type II cells is not fully understood. Vacuolar ATPase (V-ATPase is the enzyme responsible for pumping H(+ into lamellar bodies and is required for the processing of surfactant proteins and the packaging of surfactant lipids. However, its role in lung surfactant secretion is unknown. Proteomic analysis revealed that vacuolar ATPase (V-ATPase dominated the alveolar type II cell lipid raft proteome. Western blotting confirmed the association of V-ATPase a1 and B1/2 subunits with lipid rafts and their enrichment in lamellar bodies. The dissipation of lamellar body pH gradient by Bafilomycin A1 (Baf A1, an inhibitor of V-ATPase, increased surfactant secretion. Baf A1-stimulated secretion was blocked by the intracellular Ca(2+ chelator, BAPTA-AM, the protein kinase C (PKC inhibitor, staurosporine, and the Ca(2+/calmodulin-dependent protein kinase II (CaMKII, KN-62. Baf A1 induced Ca(2+ release from isolated lamellar bodies. Thapsigargin reduced the Baf A1-induced secretion, indicating cross-talk between lamellar body and endoplasmic reticulum Ca(2+ pools. Stimulation of type II cells with surfactant secretagogues dissipated the pH gradient across lamellar bodies and disassembled the V-ATPase complex, indicating the physiological relevance of the V-ATPase-mediated surfactant secretion. Finally, silencing of V-ATPase a1 and B2 subunits decreased stimulated surfactant secretion, indicating that these subunits were crucial for surfactant secretion. We conclude that V-ATPase regulates surfactant secretion via an increased Ca(2+ mobilization from lamellar bodies and endoplasmic reticulum, and the activation of PKC and CaMKII. Our finding revealed a previously unrealized role of V-ATPase in surfactant secretion.

  16. Proximity Interactions among Basal Body Components in Trypanosoma brucei Identify Novel Regulators of Basal Body Biogenesis and Inheritance

    Directory of Open Access Journals (Sweden)

    Hung Quang Dang

    2017-01-01

    Full Text Available The basal body shares similar architecture with centrioles in animals and is involved in nucleating flagellar axonemal microtubules in flagellated eukaryotes. The early-branching Trypanosoma brucei possesses a motile flagellum nucleated from the basal body that consists of a mature basal body and an adjacent pro-basal body. Little is known about the basal body proteome and its roles in basal body biogenesis and flagellar axoneme assembly in T. brucei. Here, we report the identification of 14 conserved centriole/basal body protein homologs and 25 trypanosome-specific basal body proteins. These proteins localize to distinct subdomains of the basal body, and several of them form a ring-like structure surrounding the basal body barrel. Functional characterization of representative basal body proteins revealed distinct roles in basal body duplication/separation and flagellar axoneme assembly. Overall, this work identified novel proteins required for basal body duplication and separation and uncovered new functions of conserved basal body proteins in basal body duplication and separation, highlighting an unusual mechanism of basal body biogenesis and inheritance in this early divergent eukaryote.

  17. Comparison of Appetite-regulating Hormones and Body Composition in Pediatric Patients in Predialysis Stage of Chronic Kidney Disease and Healthy Control Group

    Directory of Open Access Journals (Sweden)

    Mohammad Hassan Eftekhari

    2015-01-01

    Full Text Available Background: Protein-energy malnutrition (PEM is a common complication in pediatric patients with chronic kidney disease (CKD. Components incorporated in the regulation of appetite and body composition appear to be of the focus in renal insufficiency and may influence the CKD-associated PEM. The purpose of this study was to investigate plasma levels of appetite-regulating hormones and their correlation with the body composition variables in a pediatric in predialysis stage of CKD. Methods: Thirty children with CKD in predialysis stage were selected and compared with 30 healthy sex- and age-matched controls. Blood samples were collected in fasting. Serum total ghrelin, leptin, and obestatin levels were measured using enzyme immunometric assay methods. Anthropometric parameters measurement and body composition analysis were done using the bioelectric impedance analysis (BIA method. Results: Patients showed insignificant elevated total ghrelin (105.40±30.83 ng/l, leptin (5.32±1.17 ng/ml and obestatin (5.07±1.09 ng/ml levels in comparison with healthy participants. By using BIA, patients had significantly different Dry Lean Weight (P=0.048, Extra Cellular Water (P=0.045, Body Cell Mass (BCM (P=0.021, Basal Metabolic Rate (P=0.033 and Body Mass Index (P=0.029 compared with controls. Furthermore, the total body water was slightly and the ECW was significantly higher in CKD participants. There were significant negative correlation between obestatin and BCM (r=-0.40, P=0.03 and fat free mass index (FFMI (r=-0.40, P=0.029 in patients. Conclusion: It seems that our results are insufficient to clarify the role of appetite-regulating hormones in PEM in CKD patients. It is apparent that there are still many unknown parameters related to both appetite regulating and CKD-associated PEM.

  18. Anthropogenic change in water bodies in the southern part of the Silesian Upland

    Directory of Open Access Journals (Sweden)

    Machowski Robert

    2014-06-01

    Full Text Available The paper analyses the anthropogenic change in water bodies in the southern part of the Silesian Upland as exemplified by the town of Knurów. The assessment was based on topographic maps from the years 1827-1828, 1928-1936, 1960 and 1993, and on a 2011 orthophotomap. The cartographic materials used were processed as required for analysis purposes. Maps were calibrated in the Quantum GIS program on the basis of map corner coordinates and using the common points method. In Knurów, four main types of water bodies were distinguished with respect to their origins: reservoirs impounded by dams, flooded mineral workings, industrial water bodies and water bodies in subsidence basins and hollows. Historically, the first water bodies to appear were reservoirs impounded by dams, which dominated until the 1930s. They later fell into disuse and were completely dismantled. Water bodies in mineral workings formed in the early 20th century and were associated with the excavation of raw materials for producing bricks. The period of their greatest significance were the 1960s, when they constituted slightly more than 46% of water bodies in total and accounted for nearly 40% of overall surface area. At the end of the 19th and at the beginning of the 20th century, industrial reservoirs began to appear. Within the town of Knurów, those were sedimentation tanks that held mine water, washery effluent, backfill and cooling water, fire-fighting water pools and tanks, tanks at sewage treatment plants, industrial water tanks and others. Presently, these account for 41.4% (29 of the total number of water bodies and have a total surface area of 32.0 ha (25,2%. Within the study area, water bodies in subsidence basins and hollows only began to form in the second half of the 20th century. In 2011, such water bodies numbered 38 (54.3% and occupied an area of 90.4 ha (71.2%.

  19. Effect of ramadan fasting on body water status markers after a rugby sevens match.

    Science.gov (United States)

    Trabelsi, Khaled; Rebai, Haithem; El-Abed, Kais; Stannard, Stephen R; Khannous, Hamdi; Masmoudi, Liwa; Sahnoun, Zouheir; Hakim, Ahmed; Fellman, Nicole; Tabka, Zouhair

    2011-09-01

    To evaluate the effect of Ramadan fasting on body water status markers of rugby players at basal condition and following a simulation of rugby sevens match. TWELVE RECREATIONAL RUGBY SEVENS PLAYERS PLAYED THREE MATCHES: one day before Ramadan (before Ramadan), at the end of the first week of Ramadan (Beg-R) and at the end of Ramadan (End-R). Before and immediately after each match, body weight was determined and blood samples were taken for the measurement of body water status markers. Total body water was measured with an impedancemeter only before matches. At rest, an increase in hematocrit (+4.4%, P=0.03), hemoglobin (+3.4%, P=0.01) and plasma osmolarity (+2.8%, PRamadan. Total body water measured before Ramadan did not differ significantly from that of Ramadan. After the match, values of hematocrit and plasma osmolarity increased significantly at End-R (+1.4%, P=0.02; +3.1%, PRamadan. Although, hemoglobin measured after matches occurring during Ramadan did not differ from those of before Ramadan. In response to matches, the change of percentage of body water status markers did not differ during each period of the investigation. The present results show that Ramadan fasting induces dehydration at basal conditions. Also, rugby sevens match played during Ramadan did not exacerbate the magnitude of responses to matches of blood and body water status markers.

  20. Experimental justification of indicative microbiological values for the safety of water bodies in the recreation areas

    Directory of Open Access Journals (Sweden)

    Е.V. Drozdova

    2015-03-01

    Full Text Available The article provides the assessment of the microbiological values of water bodies if they are used for recreational purposes and distinguishes the epidemiologically significant parameters. In order to validate the indicative safety values taking into account the existing conditions of the recreational use of water we conducted the hygienic assessment of water in the water bodies used for recreational purposes under the indicative microbiological values (total microbial count, thermotolerant coliform bacteria, E. coli; enterococcus, spores of sulfite-reducing Clostridia; coliphages; Ps. aeruginosa and the content of pathogenic microorganisms; also the microbiological profile of water was identified. The obtained data will be used to improve the system for monitoring of water bodies in the recreation areas.

  1. Arsenic occurrence in water bodies in Kharaa river basin

    Directory of Open Access Journals (Sweden)

    Azzaya T

    2018-02-01

    Full Text Available Distribution of arsenic (As and its compound and related toxicology are serious concerns nowadays. Gold mining activity is one of the anthropogenic sources of environmental contamination regarding As and other heavy metals. In Mongolia, the most productive gold mining sites are placed in the Kharaa river basin. A hundred water samples were collected from river, spring and deep wells in this river basin. Along with total As and its species-As(III and As(V, examination of concentration levels of other key parameters, 21 heavy metals with pH, total hardness, electric conductivity, anion and cations, was also carried out. In respect to the permissible limit formulated by the Mongolian National Drinking water quality standard (MNS 0900:2005, As10 µg/l, the present study showed that most of samples were found no contamination. In Kharaa river basin, an average concentration of total As in surface water was 4.04 µg/l with wide range in 0.07−30.30 µg/l whereas it was 2.24 µg/l in groundwater. As analysis in surface water in licensed area of Gatsuurt gold mining showed a mean concentration with 24.90 µg/l presenting higher value than that of value in river basin by 6 orders of magnitude and it was 2 times higher than permissible level as well. In Boroo river nearby Boroo gold mining area, As concentration in water was ranged in 6.05−6.25 µg/l. Ammonia pollution may have present at estuary of Zuunmod river in Mandal sum with above the permissible level described in national water quality standard. Geological formation of the rocks and minerals affected to change of heavy metal concentration, especially As and uranium (U at spring water nearby Gatsuurt-Boroo improved road.

  2. 78 FR 10269 - National Primary Drinking Water Regulations: Revisions to the Total Coliform Rule

    Science.gov (United States)

    2013-02-13

    ... Illness CWS--Community Water System DBP--Disinfection Byproduct DWC--Drinking Water Committee EA--Economic... 141 and 142 National Primary Drinking Water Regulations: Revisions to the Total Coliform Rule; Final...-9684-8] RIN 2040-AD94 National Primary Drinking Water Regulations: Revisions to the Total Coliform Rule...

  3. 75 FR 13454 - Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY

    Science.gov (United States)

    2010-03-22

    ...-AA08 Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY AGENCY: Coast... navigable waters of Huntington Bay, New York due to the annual Fran Schnarr Open Water Championships. The..., ``Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY'' (Docket number USCG...

  4. What Happens Where the Water and the Rock Touch in Small Space Bodies

    Science.gov (United States)

    Byrne, P. K.; Regensburger, P. V.; Klimczak, C.; Bohnenstiehl, D. R.; Dombard, A. J.; Hauck, S. A., II

    2017-12-01

    There are several small space bodies that go around bigger worlds that might have a layer of water under a layer of ice. Lots of study has been done to understand the outside ice layer of these small space bodies, because the ice can tells us important things about the big water layer under it. Some of these small space bodies are very interesting because the right things for life—water, hot rock, and food—might be at the bottom of the water layer, where it touches the top of the next layer down, which is made of rock. But it is very hard to understand what this rock at the bottom of the water is like, because we can't see it. So, we are imagining what this rock is like by thinking about what the rock is like under the water layer on our own world. If hot rock comes out of the rock layer through cracks under the water, the cold of the water makes the hot rock go very cold very fast, and it makes funny rolls as it does so. This might happen on some small space bodies that are hot enough on the inside to make hot rock. We know that on our own world the rock layer under the water is wet to as far down as cracks can go, so it makes sense that this is true for small space bodies, too. We did some thinking about numbers and found out that the cracks can go a few ten hundred steps into the rock layer on small space bodies, but for bigger (well, not quite so small) space bodies, the cracks can go at least tens of ten hundred steps into the rock layer. This means that water goes into the rock layer this much, too. But get this: some small bodies are not really that small—one of them is bigger than the first world from the Sun! And on a few of these big (small) bodies, the layer of water is so heavy that the bottom of that water is pushed together from all sides and turns into a type of hot ice. This means that, for these big (small) worlds, the water can't get into the rock layer through cracks (since there is a layer of hot ice in the way), and so these bodies are

  5. Water Transport and the Evolution of CM Parent Bodies

    Science.gov (United States)

    Coker, Rob; Cohen, Barbara

    2014-01-01

    Meteorites have amino acids and hydrated minerals which constrain the peak temperature ranges they have experienced. CMs in particular have a narrow range (273-325K). Bulk fluid motion during hydration constrained to small scales (less than mm). Some asteroids are known to have hydrated minerals on their surfaces. It is presumed these two facts may be related. Problem: hydration only occurs (significantly) with liquid water; melting water only occurs early on in nebula (1-10 Myrs ANC); in nebula asteroid surface temperature very cold (approximately 150K). Can indigenous alteration produce CMs and/or surface hydration?

  6. Method and apparatus for recovering oil from an oil spill on the surface of a body of water

    International Nuclear Information System (INIS)

    Schweizer, R.W.; Patel, K.P.; Lau, P.Y.

    1991-01-01

    This patent describes a method of recovering a hydrophobic hydrocarbon oil from the surface of a body of water, the body of water having a water temperature, the oil having a specific gravity which is less than the specific gravity of the water in the body of water and a viscosity which is greater than approximately 80 centipoise at the water temperature. It comprises continuously withdrawing a feed oil-water mixture from the surface of the body of water; continuously adjusting the viscosity of the oil in the feed oil-water mixture to a level below approximately 80 centipoise to form an adjusted oil-water mixture; and continuously passing the adjusted oil-water mixture through an oil-water coalescer to separate the oil in the adjusted oil-water mixture from the water in the adjusted oil-water mixture

  7. Regulating 'unruly' bodies: work tasks, conflict and violence in Britain's night-time economy.

    Science.gov (United States)

    Monaghan, Lee F

    2002-09-01

    Security work in urban licensed premises is a risky occupation in Britain's fast expanding liminal night-time economy. Sociologically, little is known about this masculinist work, including those embodied strategies used by doorstaff or 'bouncers' to regulate 'unruly' bodies in and around commercial space. Using participant observational data generated in south-west Britain, this paper describes how the door supervisors' routine work tasks (largely comprising requests and demands) provide the conditions of possibility for hierarchical conflict and (near) violence between themselves and (potential) customers inside and at the entrances to licensed premises. Besides providing a thick description of this work and the phenomenology of physical violence, the paper supports recent theoretical arguments for an explicitly embodied sociology. Centrally, the paper maintains that bodies matter and that an empirical, interpretative sociology cannot ignore the corporeal dimensions of social life if it is to arrive at an adequate understanding of everynight tensions and conflict.

  8. Human ketone body production and utilization studied using tracer techniques: Regulation by free fatty acids, insulin, catecholamines, and thyroid hormones

    Energy Technology Data Exchange (ETDEWEB)

    Keller, U.; Lustenberger, M.; Mueller-Brand, J.G.; Gerber, P.P.; Stauffacher, W.

    1989-05-01

    Ketone body concentrations fluctuate markedly during physiological and pathological conditions. Tracer techniques have been developed in recent years to study production, utilization, and the metabolic clearance rate of ketone bodies. This review describes data on the roles of insulin, catecholamines, and thyroid hormones in the regulation of ketone body kinetics. The data indicate that insulin lowers ketone body concentrations by three independent mechanisms: first, it inhibits lipolysis, and thus lowers free fatty acid availability for ketogenesis; second, it restrains ketone body production within the liver; third, it enhances peripheral ketone body utilization. To assess these effects in humans in vivo, experimental models were developed to study insulin effects with controlled concentrations of free fatty acids, insulin, glucagon, and ketone bodies. Presently available data also support an important role of catecholamines in increasing ketone body concentrations. Evidence was presented that norepinephrine increases ketogenesis not only by stimulating lipolysis, and thus releasing free fatty acids, but also by increasing intrahepatic ketogenesis. Thyroid hormone availability was associated with lipolysis and ketogenesis. Ketone body concentrations after an overnight fast were only modestly elevated in hyperthyroidism resulting from increased peripheral ketone body clearance. There was a significant correlation between serum triiodothyronine levels and the ketone body metabolic clearance rate. Thus, ketone body homeostasis in human subjects resulted from the interaction of hormones such as insulin, catecholamines, and thyroid hormones regulating lipolysis, intrahepatic ketogenesis, and peripheral ketone body utilization. 58 references.

  9. Human ketone body production and utilization studied using tracer techniques: Regulation by free fatty acids, insulin, catecholamines, and thyroid hormones

    International Nuclear Information System (INIS)

    Keller, U.; Lustenberger, M.; Mueller-Brand, J.G.; Gerber, P.P.; Stauffacher, W.

    1989-01-01

    Ketone body concentrations fluctuate markedly during physiological and pathological conditions. Tracer techniques have been developed in recent years to study production, utilization, and the metabolic clearance rate of ketone bodies. This review describes data on the roles of insulin, catecholamines, and thyroid hormones in the regulation of ketone body kinetics. The data indicate that insulin lowers ketone body concentrations by three independent mechanisms: first, it inhibits lipolysis, and thus lowers free fatty acid availability for ketogenesis; second, it restrains ketone body production within the liver; third, it enhances peripheral ketone body utilization. To assess these effects in humans in vivo, experimental models were developed to study insulin effects with controlled concentrations of free fatty acids, insulin, glucagon, and ketone bodies. Presently available data also support an important role of catecholamines in increasing ketone body concentrations. Evidence was presented that norepinephrine increases ketogenesis not only by stimulating lipolysis, and thus releasing free fatty acids, but also by increasing intrahepatic ketogenesis. Thyroid hormone availability was associated with lipolysis and ketogenesis. Ketone body concentrations after an overnight fast were only modestly elevated in hyperthyroidism resulting from increased peripheral ketone body clearance. There was a significant correlation between serum triiodothyronine levels and the ketone body metabolic clearance rate. Thus, ketone body homeostasis in human subjects resulted from the interaction of hormones such as insulin, catecholamines, and thyroid hormones regulating lipolysis, intrahepatic ketogenesis, and peripheral ketone body utilization. 58 references

  10. Dry body weight: water and sodium removal targets in PD

    NARCIS (Netherlands)

    Krediet, Raymond T.

    2006-01-01

    BACKGROUND/AIMS: Cardiovascular mortality is high in peritoneal dialysis patients. This may be due to the presence of hypertension and fluid overload. Dietary intake of water and sodium are likely to be important, especially in anuric patients. METHODS: A review of the literature on assessment of

  11. Bubbles as a means for the deaeration of water bodies

    NARCIS (Netherlands)

    Zhang, Yuhang; Zhou, Gedi; Prosperetti, Andrea

    2017-01-01

    Occasional dissolved-air supersaturation - such as may occur, for instance, downstream of dams - is harmful to fish because it causes gas bubble disease. A counterintuitive but effective means of reducing dissolved air content is the injection of bubbles in the supersaturated water. The bubbles

  12. Whole body [O-15]water pharmacokinetics measured in blood

    NARCIS (Netherlands)

    Maguire, RP; Spyrou, NM; Leenders, KL

    A simple pharmacokinetic model to explain the time course of [0-15]water in human whole blood after bolus injection is described. The model has been derived from measurements in twelve healthy volunteers who were measured repeatedly, resulting in 67 datasets, made in the context of PET blood flow

  13. Intertidal beach sands as monitors for heavy metal pollution in coastal water bodies

    International Nuclear Information System (INIS)

    Lacerda, L.D. de; Pfeiffer, W.C.; Fiszman, M.

    Intertidal beach sands were investigated for their use as indicators of metal transport in a contaminated water body, Sepetiba Bay, Rio de Janeiro, Brazil, and are proposed as an alternative and rapid screening method to determine metal pollution status of coastal areas. The results showed that, at least for Cu, Cr, Zn and Pb, beach sands can be included in the existing environmental monitoring programs for heavy metal pollution in water bodies. (Author) [pt

  14. Body water distribution and risk of cardiovascular morbidity and mortality in a healthy population

    DEFF Research Database (Denmark)

    Knudsen, Nikoline Nygård; Kjærulff, Thora Majlund; Ward, Leigh Cordwin

    2014-01-01

    Early alterations in the cardiovascular structure and function may change normal body water distribution. The resulting fluid shifts may thus serve as an early marker for cardiovascular disease. However, studies examining this in healthy populations are absent.......Early alterations in the cardiovascular structure and function may change normal body water distribution. The resulting fluid shifts may thus serve as an early marker for cardiovascular disease. However, studies examining this in healthy populations are absent....

  15. Variation of Body Size in Rice Water Weevil (Coleoptera: Curculionidae) and Its Associations with Population Biology

    OpenAIRE

    Huang, Yunshan; Ao, Yan; Jiang, Mingxing; Way, Michael O

    2018-01-01

    Abstract Life history characteristics help us to determine the ability of invasive species to establish and thrive in an exotic environment. However, so far, there have been very few reports concerning geographic variation in the body size of invasive insects and the associations between body size variation and population biology. In this study, we surveyed the geographic variation in body size of an invasive agricultural pest, the rice water weevil Lissorhoptrus oryzophilus Kuschel (Coleopte...

  16. Fusion of radar and optical data for mapping and monitoring of water bodies

    Science.gov (United States)

    Jenerowicz, Agnieszka; Siok, Katarzyn

    2017-10-01

    Remote sensing techniques owe their great popularity to the possibility to obtain of rapid, accurate and information over large areas with optimal time, spatial and spectral resolutions. The main areas of interest for remote sensing research had always been concerned with environmental studies, especially water bodies monitoring. Many methods that are using visible and near- an infrared band of the electromagnetic spectrum had been already developed to detect surface water reservoirs. Moreover, the usage of an image obtained in visible and infrared spectrum allows quality monitoring of water bodies. Nevertheless, retrieval of water boundaries and mapping surface water reservoirs with optical sensors is still quite demanding. Therefore, the microwave data could be the perfect complement to data obtained with passive optical sensors to detect and monitor aquatic environment especially surface water bodies. This research presents the methodology to detect water bodies with open- source satellite imagery acquired with both optical and microwave sensors. The SAR Sentinel- 1 and multispectral Sentinel- 2 imagery were used to detect and monitor chosen reservoirs in Poland. In the research Level, 1 Sentinel- 2 data and Level 1 SAR images were used. SAR data were mainly used for mapping water bodies. Next, the results of water boundaries extraction with Sentinel-1 data were compared to results obtained after application of modified spectral indices for Sentinel- 2 data. The multispectral optical data can be used in the future for the evaluation of the quality of the reservoirs. Preliminary results obtained in the research had shown, that the fusion of data obtained with optical and microwave sensors allow for the complex detection of water bodies and could be used in the future quality monitoring of water reservoirs.

  17. Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body.

    Science.gov (United States)

    Lee, Yong S; Tresguerres, Martin; Hess, Kenneth; Marmorstein, Lihua Y; Levin, Lonny R; Buck, Jochen; Marmorstein, Alan D

    2011-12-02

    Glaucoma is a leading cause of blindness affecting as many as 2.2 million Americans. All current glaucoma treatment strategies aim to reduce intraocular pressure (IOP). IOP results from the resistance to drainage of aqueous humor (AH) produced by the ciliary body in a process requiring bicarbonate. Once secreted into the anterior chamber, AH drains from the eye via two pathways: uveoscleral and pressure-dependent or conventional outflow (C(t)). Modulation of "inflow" and "outflow" pathways is thought to occur via distinct, local mechanisms. Mice deficient in the bicarbonate channel bestrophin-2 (Best2), however, exhibit a lower IOP despite an increase in AH production. Best2 is expressed uniquely in nonpigmented ciliary epithelial (NPE) cells providing evidence for a bicarbonate-dependent communicative pathway linking inflow and outflow. Here, we show that bicarbonate-sensitive soluble adenylyl cyclase (sAC) is highly expressed in the ciliary body in NPE cells, but appears to be absent from drainage tissues. Pharmacologic inhibition of sAC in mice causes a significant increase in IOP due to a decrease in C(t) with no effect on inflow. In mice deficient in sAC IOP is elevated, and C(t) is decreased relative to wild-type mice. Pharmacologic inhibition of sAC did not alter IOP or C(t) in sAC-deficient mice. Based on these data we propose that the ciliary body can regulate C(t) and that sAC serves as a critical sensor of bicarbonate in the ciliary body regulating the secretion of substances into the AH that govern outflow facility independent of pressure.

  18. Role of GABA Release From Leptin Receptor-Expressing Neurons in Body Weight Regulation

    Science.gov (United States)

    Xu, Yuanzhong; O'Brien, William G.; Lee, Cheng-Chi; Myers, Martin G.

    2012-01-01

    It is well established that leptin regulates energy balance largely through isoform B leptin receptor-expressing neurons (LepR neurons) in the brain and that leptin activates one subset of LepR neurons (leptin-excited neurons) while inhibiting the other (leptin-inhibited neurons). However, the neurotransmitters released from LepR neurons that mediate leptin action in the brain are not well understood. Previous results demonstrate that leptin mainly acts on γ-aminobutyric acid (GABA)ergic neurons to reduce body weight, and that leptin activates proopiomelanocortin neuron activity by reducing GABA release onto these neurons, suggesting a body weight-promoting role for GABA released from leptin-inhibited neurons. To directly examine the role of GABA release from LepR neurons in body weight regulation, mice with disruption of GABA release specifically from LepR neurons were generated by deletion of vesicular GABA transporter in LepR neurons. Interestingly, these mice developed mild obesity on chow diet and were sensitive to diet-induced obesity, which were associated with higher food intake and lower energy expenditure. Moreover, these mice showed blunted responses in both food intake and body weight to acute leptin administration. These results demonstrate that GABA plays an important role in mediating leptin action. In combination with the previous studies that leptin reduces GABA release onto proopiomelanocortin neurons through leptin-inhibited neurons and that disruption of GABA release from agouti gene-related protein neurons, one subset of LepR-inhibited neurons, leads to a lean phenotype, our results suggest that, under our experimental conditions, GABA release from leptin-excited neuron dominates over leptin-inhibited ones. PMID:22334723

  19. Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, Jer-Yuan; Crawley, Suzanne; Chen, Michael; Ayupova, Dina A.; Lindhout, Darrin A.; Higbee, Jared; Kutach, Alan; Joo, William; Gao, Zhengyu; Fu, Diana; To, Carmen; Mondal, Kalyani; Li, Betty; Kekatpure, Avantika; Wang, Marilyn; Laird, Teresa; Horner, Geoffrey; Chan, Jackie; McEntee, Michele; Lopez, Manuel; Lakshminarasimhan, Damodharan; White, Andre; Wang, Sheng-Ping; Yao, Jun; Yie, Junming; Matern, Hugo; Solloway, Mark; Haldankar, Raj; Parsons, Thomas; Tang, Jie; Shen, Wenyan D.; Alice Chen, Yu; Tian, Hui; Allan, Bernard B.

    2017-09-27

    Under homeostatic conditions, animals use well-defined hypothalamic neural circuits to help maintain stable body weight, by integrating metabolic and hormonal signals from the periphery to balance food consumption and energy expenditure1,2. In stressed or disease conditions, however, animals use alternative neuronal pathways to adapt to the metabolic challenges of altered energy demand3. Recent studies have identified brain areas outside the hypothalamus that are activated under these ‘non-homeostatic’ conditions4,5,6, but the molecular nature of the peripheral signals and brain-localized receptors that activate these circuits remains elusive. Here we identify glial cell-derived neurotrophic factor (GDNF) receptor alpha-like (GFRAL) as a brainstem-restricted receptor for growth and differentiation factor 15 (GDF15). GDF15 regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses; we show that Gfral knockout mice are hyperphagic under stressed conditions and are resistant to chemotherapy-induced anorexia and body weight loss. GDF15 activates GFRAL-expressing neurons localized exclusively in the area postrema and nucleus tractus solitarius of the mouse brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitute part of the ‘emergency circuit’ that shapes feeding responses to stressful conditions7. GDF15 levels increase in response to tissue stress and injury, and elevated levels are associated with body weight loss in numerous chronic human diseases8,9. By isolating GFRAL as the receptor for GDF15-induced anorexia and weight loss, we identify a mechanistic basis for the non-homeostatic regulation of neural circuitry by a peripheral signal associated with tissue damage and stress. These findings provide opportunities to develop therapeutic agents for the treatment of disorders with altered energy demand.

  20. Comparison between legal regulations on radiation protection issued by two governmental bodies

    International Nuclear Information System (INIS)

    Jonchev, L.

    1996-01-01

    Legal problems evolving from the equivalence of the rights and obligations of two Bulgarian governmental regulatory bodies: the Ministry of Health and the Committee on the Use of Atomic Energy for Peaceful Purposes (CUAEPP) are discussed. The adequate texts in the legal regulations showing some contradictory and conflicting topics are considered. Special attention is paid to the issues of licensing and regulatory responsibilities of both organizations as well as liquidation of accident consequences. Some proposals for elimination of the discrepancies in those documents are given. 8 refs. (author)

  1. GCN5 Regulates FGF Signaling and Activates Selective MYC Target Genes during Early Embryoid Body Differentiation

    Directory of Open Access Journals (Sweden)

    Li Wang

    2018-01-01

    Full Text Available Precise control of gene expression during development is orchestrated by transcription factors and co-regulators including chromatin modifiers. How particular chromatin-modifying enzymes affect specific developmental processes is not well defined. Here, we report that GCN5, a histone acetyltransferase essential for embryonic development, is required for proper expression of multiple genes encoding components of the fibroblast growth factor (FGF signaling pathway in early embryoid bodies (EBs. Gcn5−/− EBs display deficient activation of ERK and p38, mislocalization of cytoskeletal components, and compromised capacity to differentiate toward mesodermal lineage. Genomic analyses identified seven genes as putative direct targets of GCN5 during early differentiation, four of which are cMYC targets. These findings established a link between GCN5 and the FGF signaling pathway and highlighted specific GCN5-MYC partnerships in gene regulation during early differentiation.

  2. Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.

    Science.gov (United States)

    Nordström, Viola; Willershäuser, Monja; Herzer, Silke; Rozman, Jan; von Bohlen Und Halbach, Oliver; Meldner, Sascha; Rothermel, Ulrike; Kaden, Sylvia; Roth, Fabian C; Waldeck, Clemens; Gretz, Norbert; de Angelis, Martin Hrabě; Draguhn, Andreas; Klingenspor, Martin; Gröne, Hermann-Josef; Jennemann, Richard

    2013-01-01

    Hypothalamic neurons are main regulators of energy homeostasis. Neuronal function essentially depends on plasma membrane-located gangliosides. The present work demonstrates that hypothalamic integration of metabolic signals requires neuronal expression of glucosylceramide synthase (GCS; UDP-glucose:ceramide glucosyltransferase). As a major mechanism of central nervous system (CNS) metabolic control, we demonstrate that GCS-derived gangliosides interacting with leptin receptors (ObR) in the neuronal membrane modulate leptin-stimulated formation of signaling metabolites in hypothalamic neurons. Furthermore, ganglioside-depleted hypothalamic neurons fail to adapt their activity (c-Fos) in response to alterations in peripheral energy signals. Consequently, mice with inducible forebrain neuron-specific deletion of the UDP-glucose:ceramide glucosyltransferase gene (Ugcg) display obesity, hypothermia, and lower sympathetic activity. Recombinant adeno-associated virus (rAAV)-mediated Ugcg delivery to the arcuate nucleus (Arc) significantly ameliorated obesity, specifying gangliosides as seminal components for hypothalamic regulation of body energy homeostasis.

  3. Predicting hydrocarbon potential of an earth formation underlying a body of water

    International Nuclear Information System (INIS)

    Kaplan, I.R.; Demaison, G.J.

    1983-01-01

    A method for the on-site collection and examination of small concentrations of methane dissolved in water so as to predict hydrocarbon potential of an earth formation underlying a body of water, said formation being a source of said methane, comprises: (i) sampling the water; (ii) continuously vacuum separating said water into liquid and gas phases; (iii) quantitatively separating interfering gas species from methane; (iv) quantitatively oxidising said methane; (v) cryogenically trapping the resulting gaseous carbon dioxide and water vapor at a trapping station, and (vi) isotopically examining said trapped carbon dioxide and water vapour for carbon and deuterium distribution. (author)

  4. VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle.

    Science.gov (United States)

    Cantarero, Lara; Sanz-García, Marta; Vinograd-Byk, Hadar; Renbaum, Paul; Levy-Lahad, Ephrat; Lazo, Pedro A

    2015-06-12

    Cajal bodies (CBs) are nuclear organelles associated with ribonucleoprotein functions and RNA maturation. CBs are assembled on coilin, its main scaffold protein, in a cell cycle dependent manner. The Ser-Thr VRK1 (vaccinia-related kinase 1) kinase, whose activity is also cell cycle regulated, interacts with and phosphorylates coilin regulating assembly of CBs. Coilin phosphorylation is not necessary for its interaction with VRK1, but it occurs in mitosis and regulates coilin stability. Knockdown of VRK1 or VRK1 inactivation by serum deprivation causes a loss of coilin phosphorylation in Ser184 and of CBs formation, which are rescued with an active VRK1, but not by kinase-dead VRK1. The phosphorylation of coilin in Ser184 occurs during mitosis before assembly of CBs. Loss of coilin phosphorylation results in disintegration of CBs, and of coilin degradation that is prevented by proteasome inhibitors. After depletion of VRK1, coilin is ubiquitinated in nuclei, which is partly mediated by mdm2, but its proteasomal degradation occurs in cytosol and is prevented by blocking its nuclear export. We conclude that VRK1 is a novel regulator of CBs dynamics and stability in cell cycle by protecting coilin from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.

  5. Hierarchical clusters of phytoplankton variables in dammed water bodies

    Science.gov (United States)

    Silva, Eliana Costa e.; Lopes, Isabel Cristina; Correia, Aldina; Gonçalves, A. Manuela

    2017-06-01

    In this paper a dataset containing biological variables of the water column of several Portuguese reservoirs is analyzed. Hierarchical cluster analysis is used to obtain clusters of phytoplankton variables of the phylum Cyanophyta, with the objective of validating the classification of Portuguese reservoirs previewly presented in [1] which were divided into three clusters: (1) Interior Tagus and Aguieira; (2) Douro; and (3) Other rivers. Now three new clusters of Cyanophyta variables were found. Kruskal-Wallis and Mann-Whitney tests are used to compare the now obtained Cyanophyta clusters and the previous Reservoirs clusters, in order to validate the classification of the water quality of reservoirs. The amount of Cyanophyta algae present in the reservoirs from the three clusters is significantly different, which validates the previous classification.

  6. Development of Thresholds and Exceedance Probabilities for Influent Water Quality to Meet Drinking Water Regulations

    Science.gov (United States)

    Reeves, K. L.; Samson, C.; Summers, R. S.; Balaji, R.

    2017-12-01

    Drinking water treatment utilities (DWTU) are tasked with the challenge of meeting disinfection and disinfection byproduct (DBP) regulations to provide safe, reliable drinking water under changing climate and land surface characteristics. DBPs form in drinking water when disinfectants, commonly chlorine, react with organic matter as measured by total organic carbon (TOC), and physical removal of pathogen microorganisms are achieved by filtration and monitored by turbidity removal. Turbidity and TOC in influent waters to DWTUs are expected to increase due to variable climate and more frequent fires and droughts. Traditional methods for forecasting turbidity and TOC require catchment specific data (i.e. streamflow) and have difficulties predicting them under non-stationary climate. A modelling framework was developed to assist DWTUs with assessing their risk for future compliance with disinfection and DBP regulations under changing climate. A local polynomial method was developed to predict surface water TOC using climate data collected from NOAA, Normalized Difference Vegetation Index (NDVI) data from the IRI Data Library, and historical TOC data from three DWTUs in diverse geographic locations. Characteristics from the DWTUs were used in the EPA Water Treatment Plant model to determine thresholds for influent TOC that resulted in DBP concentrations within compliance. Lastly, extreme value theory was used to predict probabilities of threshold exceedances under the current climate. Results from the utilities were used to produce a generalized TOC threshold approach that only requires water temperature and bromide concentration. The threshold exceedance model will be used to estimate probabilities of exceedances under projected climate scenarios. Initial results show that TOC can be forecasted using widely available data via statistical methods, where temperature, precipitation, Palmer Drought Severity Index, and NDVI with various lags were shown to be important

  7. How close do we live to water? A global analysis of population distance to freshwater bodies.

    Directory of Open Access Journals (Sweden)

    Matti Kummu

    Full Text Available Traditionally, people have inhabited places with ready access to fresh water. Today, over 50% of the global population lives in urban areas, and water can be directed via tens of kilometres of pipelines. Still, however, a large part of the world's population is directly dependent on access to natural freshwater sources. So how are inhabited places related to the location of freshwater bodies today? We present a high-resolution global analysis of how close present-day populations live to surface freshwater. We aim to increase the understanding of the relationship between inhabited places, distance to surface freshwater bodies, and climatic characteristics in different climate zones and administrative regions. Our results show that over 50% of the world's population lives closer than 3 km to a surface freshwater body, and only 10% of the population lives further than 10 km away. There are, however, remarkable differences between administrative regions and climatic zones. Populations in Australia, Asia, and Europe live closest to water. Although populations in arid zones live furthest away from freshwater bodies in absolute terms, relatively speaking they live closest to water considering the limited number of freshwater bodies in those areas. Population distributions in arid zones show statistically significant relationships with a combination of climatic factors and distance to water, whilst in other zones there is no statistically significant relationship with distance to water. Global studies on development and climate adaptation can benefit from an improved understanding of these relationships between human populations and the distance to fresh water.

  8. Effects of immersion water temperature on whole-body fluid distribution in humans.

    Science.gov (United States)

    Stocks, J M; Patterson, M J; Hyde, D E; Jenkins, A B; Mittleman, K D; Taylor, N A S

    2004-09-01

    In this study, we quantified acute changes in the intracellular and extracellular fluid compartments during upright neutral- and cold-water immersion. We hypothesized that, during short-term cold immersion, fluid shifts would be wholly restricted to the extracellular space. Seven males were immersed 30 days apart: control (33.3 degrees SD 0.6 degrees C); and cold (18.1 degrees SD 0.3 degrees C). Posture was controlled for 4 h prior to a 60-min seated immersion. Significant reductions in terminal oesophageal (36.9 degrees +/- 0.1 degrees -36.3 degrees +/- 0.1 degrees C) and mean skin temperatures (30.3 degrees +/- 0.3 degrees -23.0 degrees +/- 0.3 degrees C) were observed during the cold, but not the control immersion. Both immersions elicited a reduction in intracellular fluid [20.17 +/- 6.02 mL kg(-1) (control) vs. 22.72 +/- 9.90 mL kg(-1)], while total body water (TBW) remained stable. However, significant plasma volume (PV) divergence was apparent between the trials at 60 min [12.5 +/- 1.0% (control) vs. 6.1 +/- 3.1%; P cold immersion, consistent with its role in PV regulation. We observed that, regardless of the direction of the PV change, both upright immersions elicited reductions in intracellular fluid. These observations have two implications. First, one cannot assume that PV changes reflect those of the entire extracellular compartment. Second, since immersion also increases interstitial fluid pressure, fluid leaving the interstitium must have been rapidly replaced by intracellular water.

  9. Effect of Ramadan Fasting on Body Water Status Markers after a Rugby Sevens Match

    OpenAIRE

    Trabelsi, Khaled; Rebai, Haithem; el-Abed, Kais; Stannard, Stephen R.; Khannous, Hamdi; Masmoudi, Liwa; Sahnoun, Zouheir; Hakim, Ahmed; Fellman, Nicole; Tabka, Zouhair

    2011-01-01

    Purpose To evaluate the effect of Ramadan fasting on body water status markers of rugby players at basal condition and following a simulation of rugby sevens match. Methods Twelve recreational rugby sevens players played three matches: one day before Ramadan (before Ramadan), at the end of the first week of Ramadan (Beg-R) and at the end of Ramadan (End-R). Before and immediately after each match, body weight was determined and blood samples were taken for the measurement of body water status...

  10. 78 FR 47241 - Amendments to the Water Quality Regulations, Water Code and Comprehensive Plan To Revise the...

    Science.gov (United States)

    2013-08-05

    ... DELAWARE RIVER BASIN COMMISSION 18 CFR Part 410 Amendments to the Water Quality Regulations, Water Code and Comprehensive Plan To Revise the Human Health Water Quality Criteria for PCBs in Zones 2... hold a public hearing to receive comments on proposed amendments to the Commission's Water Quality...

  11. To What Extent is Drinking Water Tested in Sub-Saharan Africa? A Comparative Analysis of Regulated Water Quality Monitoring

    OpenAIRE

    Rachel Peletz; Emily Kumpel; Mateyo Bonham; Zarah Rahman; Ranjiv Khush

    2016-01-01

    Water quality information is important for guiding water safety management and preventing water-related diseases. To assess the current status of regulated water quality monitoring in sub-Saharan Africa, we evaluated testing programs for fecal contamination in 72 institutions (water suppliers and public health agencies) across 10 countries. Data were collected through written surveys, in-person interviews, and analysis of microbial water quality testing levels. Though most institutions did no...

  12. Structural investigation of water-soluble polysaccharides extracted from the fruit bodies of Coprinus comatus

    NARCIS (Netherlands)

    Li, Bo; Dobruchowska, Justyna M.; Gerwig, Gerrit J.; Dijkhuizen, Lubbert; Kamerling, Johannis P.

    2013-01-01

    Water-soluble polysaccharide material, extracted from the stipes of the fruit bodies of Coprinus comatus by hot water, was fractionated by sequential weak anion-exchange and size-exclusion chromatography. The relevant fractions were subjected to structural analysis, including (D/L)

  13. The lateral hypothalamic area revisited: neuroanatomy, body weight regulation, neuroendocrinology and metabolism.

    Science.gov (United States)

    Bernardis, L L; Bellinger, L L

    1993-01-01

    This article reviews findings that have accumulated since the original description of the syndrome that follows destruction of the lateral hypothalamic area (LHA). These data comprise the areas of neuroanatomy, body weight regulation, neuroendocrinology, neurochemistry, and intermediary metabolism. Neurons in the LHA are the largest in the hypothalamus, and are topographically well organized. The LHA belongs to the parasympathetic area of the hypothalamus, and connects with all major parts of the brain and the major hypothalamic nuclei. Rats with LHA lesions regulate their body weight set point in a primary manner and not because of destruction of a "feeding center". The lower body weight is not due to finickiness. In the early stages of the syndrome, catabolism and running activity are enhanced, and so is the activity of the sympathetic nervous system (SNS) as shown by increased norepinephrine excretion that normalizes one mo later. The LHA plays a role in the feedback control of body weight regulation different from ventromedial (VMN) and dorsomedial (DMN). Tissue preparations from the LHA promote glucose utilization and insulin release. Although it does not belong to the classical hypothysiotropic area of the hypothalamus, the LHA does affect neuroendocrine secretions. No plasma data on growth hormone are available following electrolytic lesions LHA but electrical stimulation fails to elicit GH secretion. Nevertheless, antiserum raised against the 1-37 fragment of human GHRF stains numerous perikarya in the dorsolateral LHA. The plasma circadian corticosterone rhythm is disrupted in LHA lesioned rats, but this is unlikely due to destruction of intrinsic oscillators. Stimulation studies show a profound role of the LHA in glucose metabolism (glycolysis, glycogenesis, gluconeogenesis), this mechanism being cholinergic. Its role in lipolysis appears not to be critical. In general, stimulation of the VMN elicits opposite effects. Lesion studies in rats show altered

  14. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1.

    Directory of Open Access Journals (Sweden)

    Kevin T Jones

    2009-03-01

    Full Text Available The target of rapamycin (TOR kinase coordinately regulates fundamental metabolic and cellular processes to support growth, proliferation, survival, and differentiation, and consequently it has been proposed as a therapeutic target for the treatment of cancer, metabolic disease, and aging. The TOR kinase is found in two biochemically and functionally distinct complexes, termed TORC1 and TORC2. Aided by the compound rapamycin, which specifically inhibits TORC1, the role of TORC1 in regulating translation and cellular growth has been extensively studied. The physiological roles of TORC2 have remained largely elusive due to the lack of pharmacological inhibitors and its genetic lethality in mammals. Among potential targets of TORC2, the pro-survival kinase AKT has garnered much attention. Within the context of intact animals, however, the physiological consequences of phosphorylation of AKT by TORC2 remain poorly understood. Here we describe viable loss-of-function mutants in the Caenorhabditis elegans homolog of the TORC2-specific component, Rictor (CeRictor. These mutants display a mild developmental delay and decreased body size, but have increased lipid storage. These functions of CeRictor are not mediated through the regulation of AKT kinases or their major downstream target, the insulin-regulated FOXO transcription factor DAF-16. We found that loss of sgk-1, a homolog of the serum- and glucocorticoid-induced kinase, mimics the developmental, growth, and metabolic phenotypes of CeRictor mutants, while a novel, gain-of-function mutation in sgk-1 suppresses these phenotypes, indicating that SGK-1 is a mediator of CeRictor activity. These findings identify new physiological roles for TORC2, mediated by SGK, in regulation of C. elegans lipid accumulation and growth, and they challenge the notion that AKT is the primary effector of TORC2 function.

  15. Consideration on risk of drinking water. How was the regulation value in water decided?

    International Nuclear Information System (INIS)

    Murakami Michio

    2011-01-01

    This is an explanatory lecture record of the title subject, motivated by detection of radioactivity in tap water of Tokyo (I-131, 30 Bq/kg) in March 2011. The author explains the process of the detection in comparison with radioactivity in the vegetables and Fukushima spinach, and refers with temporary regulation values (March to April) of Cs-134, 137, U and Pu/transuranium elements as well as I-131 in drinking water and other foods. Also commented is that even water with satisfactorily less than the standard value cannot be said to be absolutely safe. Japan generally decides the standard value based on World Health Organization (WHO) guideline which assumes no threshold for radiation carcinogenesis. Relationship between low dose exposure in Hiroshima and carcinogenesis is obscure, of which situation is also similar in Chinese Guangdon where natural dose is always higher than other areas of the world. The regulation values above are derived from the index values decided by Nuclear Safety Committee of Japan (NSCJ) and Codex committee founded by FAO and WHO, and used at emergency, not at ordinary. Then explained are concept for calculation of regulation values, actual calculating equations of the value for water according to WHO, Codex and NSCJ, and of index values of I-131 and Cs by NSCJ. Exposure dose by I-131 in water and food in Tokyo is actually estimated in this paper to consider its risk (carcinogenic, 0.3/100 thousands people/year) by comparison with other matters like arsenic exposure (1.3) and traffic accident (deaths, 4.5). Lastly, the author warns with Sedgwick's words that Standards are devices to keep the lazy mind from thinking. (T.T.)

  16. Chemical composition of water hyacinth (Eichhronia Crassipes) a comparison indication of heavy metal pollution in egyptian water bodies. Vol. 4

    International Nuclear Information System (INIS)

    Abdel-sabour, M.F.; Abdel-Haleem, A.S.; Zohny, E.

    1996-01-01

    Water hyacinth is tested as an indicator for pollution in egyptian fresh surface waters. Chemical composition of water hyacinth as affected area of collection (water bodies) was studied and the suitability of this plant as a biological indicator for water pollution is discussed. Water hyacinth samples were collected three times per year for two years (1991-1993). Sample sites include one location in the river nile (at Helwan area), one site in Ismaillia canal, (at Mostrod industrial area), and one site in Abo-Zabal drain (at Abo-Zabal city). The concentration of 19 major major and trace elements in plant samples were determined by prompt gamma-ray neutron activation analysis. Results indicated that plant parts as well as location have a significant effect on elements content. Water hyacinth roots showed high affinity for accumulation of trace elements. 5 tabs

  17. Chemical composition of water hyacinth (Eichhronia Crassipes) a comparison indication of heavy metal pollution in egyptian water bodies. Vol. 4

    Energy Technology Data Exchange (ETDEWEB)

    Abdel-sabour, M F [Soil pollution unit, Soil and water Department. Nuclear Research Center, Atomic Energy Authority, Cairo (Egypt); Abdel-Haleem, A S [Hot Lab. Center, Atomic Energy Authority, Cairo (Egypt); Zohny, E [Physics Department, Faculty of Science, Cairo University, Beni-Sweif Branch, Cairo (Egypt)

    1996-03-01

    Water hyacinth is tested as an indicator for pollution in egyptian fresh surface waters. Chemical composition of water hyacinth as affected area of collection (water bodies) was studied and the suitability of this plant as a biological indicator for water pollution is discussed. Water hyacinth samples were collected three times per year for two years (1991-1993). Sample sites include one location in the river nile (at Helwan area), one site in Ismaillia canal, (at Mostrod industrial area), and one site in Abo-Zabal drain (at Abo-Zabal city). The concentration of 19 major major and trace elements in plant samples were determined by prompt gamma-ray neutron activation analysis. Results indicated that plant parts as well as location have a significant effect on elements content. Water hyacinth roots showed high affinity for accumulation of trace elements. 5 tabs.

  18. VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters.

    Science.gov (United States)

    Jethwa, Preeti H; Warner, Amy; Nilaweera, Kanishka N; Brameld, John M; Keyte, John W; Carter, Wayne G; Bolton, Neil; Bruggraber, Michael; Morgan, Peter J; Barrett, Perry; Ebling, Francis J P

    2007-08-01

    The Siberian hamster survives winter by decreasing food intake and catabolizing abdominal fat reserves, resulting in a sustained, profound loss of body weight. VGF gene expression is photoperiodically regulated in the hypothalamus with significantly higher expression in lean Siberian hamsters. The aim of this study was to investigate the role of VGF in regulating these seasonal cycles by determining the effects of a VGF-derived peptide (TLQP-21) on food intake and body weight. Acute intracerebroventricular administration of TLQP-21 decreased food intake, and chronic treatment caused a sustained reduction in food intake and body weight and decreased abdominal fat depots. Behavioral analysis revealed that TLQP-21 reduced meal size but not the frequency of feeding bouts, suggesting a primary action on satiety. Hamsters treated with TLQP-21 lost a similar amount of weight as a pair-fed group in which food intake was matched to that of the TLQP-21-treated group. Central or peripheral treatment with TLQP-21 did not produce a significant effect on resting metabolic rate. We conclude that the primary action of TLQP-21 is to decrease food intake rather than increase energy expenditure. TLQP-21 treatment caused a decrease in UCP-1 mRNA in brown adipose tissue, but hypothalamic expression of orexigenic and anorexigenic neuropeptide genes remained unchanged after TLQP-21 treatment, although compensatory increases in NPY and AgRP mRNA were observed in the pair-fed hamsters. The effects of TLQP-21 administration are similar to those in hamsters in short days, suggesting that increased VGF activity may contribute to the hypophagia that underlies the seasonal catabolic state.

  19. Analysis of mining-medicinal waters regulation. Possible treatments

    Directory of Open Access Journals (Sweden)

    María del Mar Corral Lledó

    2006-12-01

    Full Text Available The mineral waters have been a part of our lives for many centuries, since they are believe to be beneficial and to have therapeutic properties for the human health. This fact makes a key issue to provide an analyses od the current legislation on this issue ( Royal Decree-Law 743/1928, April 25th, that aproves the statute on exploitation of spring of mineral and medicinal water; Mining Law of 1973 and its regulations, in order to determine the treatments that may be applied to these watersm meanly in the case of Legionella appearance, or as preventive maesure of it. The results of this analysis shows that there is no limitation or prohibition in the treatments to what they may be subjected, as long as their physico-chemical characteristic remains altered. Contamination by Legionella bacterium, is nowadays an issue of concern, and that is reason why Public Health Authority has established the quidelines to apply for spas in order to avoid or fight a possible outbreak.

  20. Kindergarten Self-Regulation as a Predictor of Body Mass Index and Sports Participation in Fourth Grade Students

    Science.gov (United States)

    Piche, Genevieve; Fitzpatrick, Caroline; Pagani, Linda S.

    2012-01-01

    Identifying early precursors of body mass index (BMI) and sports participation represents an important concern from a public health perspective and can inform the development of preventive interventions. This article examines whether kindergarten child self-regulation, as measured by classroom engagement and behavioral regulation, predicts healthy…

  1. A new body for the regulation of radiation usage in Australia

    Energy Technology Data Exchange (ETDEWEB)

    Lokan, K.H. [Australian Radiation Laboratory, Yallambie, VIC, (Australia)

    1997-12-31

    The Australian government announced recently that it will establish an Australian Radiation and Nuclear Safety Agency ( ARPANSA ) by merging the activities of the Australian Radiation Laboratory and the Nuclear Safety Bureau and providing for the regulation of the Commonwealth`s own activities in the use of radiation and in nuclear activities. The new body will provide the nation with advice on all matters concerned with the safety of radiation and nuclear activities and will promote the development of uniform national regulatory approaches in which Commonwealth and the States and Territories would operate the control of radiation-related activities. To achieve this purpose, the new regulatory regime should aims to establish: a system of licensing of persons and organisations to possess, use, or sell sources of radiation; a system of registration of radiation and premises where radiation sources may be used; regulations which require compliance by those possessing, using or selling radiation sources; and exemptions from regulations and enforcement procedures where the hazard is so small as to be negligible.

  2. A new body for the regulation of radiation usage in Australia

    International Nuclear Information System (INIS)

    Lokan, K.H.

    1997-01-01

    The Australian government announced recently that it will establish an Australian Radiation and Nuclear Safety Agency ( ARPANSA ) by merging the activities of the Australian Radiation Laboratory and the Nuclear Safety Bureau and providing for the regulation of the Commonwealth's own activities in the use of radiation and in nuclear activities. The new body will provide the nation with advice on all matters concerned with the safety of radiation and nuclear activities and will promote the development of uniform national regulatory approaches in which Commonwealth and the States and Territories would operate the control of radiation-related activities. To achieve this purpose, the new regulatory regime should aims to establish: a system of licensing of persons and organisations to possess, use, or sell sources of radiation; a system of registration of radiation and premises where radiation sources may be used; regulations which require compliance by those possessing, using or selling radiation sources; and exemptions from regulations and enforcement procedures where the hazard is so small as to be negligible

  3. The Impact Analysis of Water Body Landscape Pattern on Urban Heat Island: A Case Study of Wuhan City

    Directory of Open Access Journals (Sweden)

    Bohan Yang

    2015-01-01

    Full Text Available Based on the LST and the landscape metrics of water body with remote sensing technique and spatial analysis, the relationship between the mean LST and the attributes of water body was revealed via Pearson’s correlation analysis and multiple stepwise regression analysis. Result showed that, in 32 class-based metrics we selected, the proportion of water body, average water body size, the isolation and fragmentation of water body, and other eight metrics have high correlation with the LST. As a resultant force, the quantity, shape, and spatial distribution of water body affect the forming of temperature. We found that the quantity and spatial pattern of city water body could be allocated reasonably to maximize its cooling effect.

  4. Body ion loss as a bioindicator of water quality impaired by coal mining

    International Nuclear Information System (INIS)

    Grippo, R.S.; Dunson, W.A.

    1994-01-01

    Protection of surface waters receiving discharges from coal mines is currently based on performance standards set by the EPA after passage of the Clean Water Act. These standards were technology-driven and reflect the Best Achievable Control Technology (BAT) available at the time of promulgation. Changes proposed as part of the upcoming reauthorization of the US Clean Water Act suggest that such technology-based standards may be reevaluated in light of more recent information on the toxicological effect of mine discharges on aquatic biota. The authors present here a physiological-based method for evaluating the site-specific toxicity of mine-derived discharges into receiving waters. They tested the usefulness of the body ion loss rate bioassay by exposing fathead minnows, brook charr and stoneflies to coal mine-impacted waters (elevated acidity and trace metals) in the field and to artificial mine water (AMW) in the laboratory. Body ion loss rate was significantly correlated with levels of mine pollution in the field. Body ion loss measured in AMW revealed strong interactions between metals and acid. Because the test animals exhibited differing levels of sensitivity to mine discharge, the selection of an appropriate organism for the body ion loss bioassay may vary depending on the (1) physical characteristics, (2) chemical characteristics and (3) pre-existing level of mine impact of the receiving waters

  5. Collaboration of representatives of the TUeVs and the Institute for Reactor Safety (IRS) in regulating bodies

    International Nuclear Information System (INIS)

    1976-03-01

    When compiling technical regulations or discussing the contents of technical regulations in regulating bodies, the representatives of the TUeVs and the IRS are to explain their points of view with arguments pertaining to the matter on hand. Reference to preceding agreements reached in internal bodies of the TUeVs or to directive decisions of the 'TUeV-Leitstelle Kerntechnik' alone cannot and must not replace a pertinent argumentation. If the majority of the body cannot agree with such a pertinent argumentation the representatives of TUeV/IRS are to ask for adjournment of the problem til the next session of the body in order to allow the counter-arguments to be thought over and to initiate new internal consulations of the TUeVs. (orig./HP) [de

  6. Discrete simulations of spatio-temporal dynamics of small water bodies under varied stream flow discharges

    Science.gov (United States)

    Daya Sagar, B. S.

    2005-01-01

    Spatio-temporal patterns of small water bodies (SWBs) under the influence of temporally varied stream flow discharge are simulated in discrete space by employing geomorphologically realistic expansion and contraction transformations. Cascades of expansion-contraction are systematically performed by synchronizing them with stream flow discharge simulated via the logistic map. Templates with definite characteristic information are defined from stream flow discharge pattern as the basis to model the spatio-temporal organization of randomly situated surface water bodies of various sizes and shapes. These spatio-temporal patterns under varied parameters (λs) controlling stream flow discharge patterns are characterized by estimating their fractal dimensions. At various λs, nonlinear control parameters, we show the union of boundaries of water bodies that traverse the water body and non-water body spaces as geomorphic attractors. The computed fractal dimensions of these attractors are 1.58, 1.53, 1.78, 1.76, 1.84, and 1.90, respectively, at λs of 1, 2, 3, 3.46, 3.57, and 3.99. These values are in line with general visual observations.

  7. Discrete simulations of spatio-temporal dynamics of small water bodies under varied stream flow discharges

    Directory of Open Access Journals (Sweden)

    B. S. Daya Sagar

    2005-01-01

    Full Text Available Spatio-temporal patterns of small water bodies (SWBs under the influence of temporally varied stream flow discharge are simulated in discrete space by employing geomorphologically realistic expansion and contraction transformations. Cascades of expansion-contraction are systematically performed by synchronizing them with stream flow discharge simulated via the logistic map. Templates with definite characteristic information are defined from stream flow discharge pattern as the basis to model the spatio-temporal organization of randomly situated surface water bodies of various sizes and shapes. These spatio-temporal patterns under varied parameters (λs controlling stream flow discharge patterns are characterized by estimating their fractal dimensions. At various λs, nonlinear control parameters, we show the union of boundaries of water bodies that traverse the water body and non-water body spaces as geomorphic attractors. The computed fractal dimensions of these attractors are 1.58, 1.53, 1.78, 1.76, 1.84, and 1.90, respectively, at λs of 1, 2, 3, 3.46, 3.57, and 3.99. These values are in line with general visual observations.

  8. The roles of the amygdala in the affective regulation of body, brain, and behaviour

    Science.gov (United States)

    Mirolli, Marco; Mannella, Francesco; Baldassarre, Gianluca

    2010-09-01

    Despite the great amount of knowledge produced by the neuroscientific literature on affective phenomena, current models tackling non-cognitive aspects of behaviour are often bio-inspired but rarely bio-constrained. This paper presents a theoretical account of affective systems centred on the amygdala (Amg). This account aims to furnish a general framework and specific pathways to implement models that are more closely related to biological evidence. The Amg, which receives input from brain areas encoding internal states, innately relevant stimuli, and innately neutral stimuli, plays a fundamental role in the motivational and emotional processes of organisms. This role is based on the fact that Amg implements the two associative processes at the core of Pavlovian learning (conditioned stimulus (CS)-unconditioned stimulus (US) and CS-unconditioned response (UR) associations), and that it has the capacity of modulating these associations on the basis of internal states. These functionalities allow the Amg to play an important role in the regulation of the three fundamental classes of affective responses (namely, the regulation of body states, the regulation of brain states via neuromodulators, and the triggering of a number of basic behaviours fundamental for adaptation) and in the regulation of three high-level cognitive processes (namely, the affective labelling of memories, the production of goal-directed behaviours, and the performance of planning and complex decision-making). Our analysis is conducted within a methodological approach that stresses the importance of understanding the brain within an evolutionary/adaptive framework and with the aim of isolating general principles that can potentially account for the wider possible empirical evidence in a coherent fashion.

  9. roposal on the Method of Regulating Ascending Kidney Water and Descending Heart Fire -through pharmacopuncture technique-

    Directory of Open Access Journals (Sweden)

    Ki Rok, Kwon

    2007-12-01

    Full Text Available Objectives : The purpose of this study is aimed at diagnosing and suggesting treatment plans for commonly seen clinical manifestation of heat symptom in the upper body and coldness in the lower body, also known as hot above, cold below syndrome. Methods : Various reasons attribute to the presence of hot above, cold below syndrome, but mainly contributed by blockage of normal Qi flow by abnormality of heart-kidney root, spleen-stomach axis, and liver-lung axis. Diagnosing these abnormalities and timely alleviation to the healthy state is presented in the study. Results : 1For heat in the upper body, Huang Lian Jie Du Tang(黃連解毒湯, CF, or JsD pharmacopuctures are injected on GB21, GB20. Qi stagnation in the thoracic area is treated with BUM injection on CV17. For impairment of transportation and transformation in the middle energizer, BUM pharmacopuncture is injected on CV12. Coldness in the lower energizer was relieved by bee venom or Sweet BV(Bee Venom free from enzymes on CV6. Conclusion : Above proposed methods of regulating water-fire were effective in treating hot above, cold below syndrome in clinical manifestations. But once the symptom subsides, treatment focused on eliminating innate cause should be rendered to achieve more successful results.

  10. [Differences of inherent optical properties of inland lake water body in typical seasons].

    Science.gov (United States)

    Sun, De-Yong; Li, Yun-Mei; Wang, Qiao; Le, Cheng-Fen; Huang, Chang-Chun; Wang, Li-Zhen

    2008-05-01

    Inherent optical property is one of the important properties of water body, which lays the foundation for the establishment of water color analytical models. By using quantity filter technology (QFT) and BB9 backscattering meter, the absorption coefficients of chromophoric dissolved organic matter (CDOM) and total suspended matters (TSM) and the backscattering coefficient of TSM in the water body at Meiliang Bay of Taihu Lake were measured in summer and winter. Based on the spectral comparison of the absorption and backscattering coefficients, their differences between the two seasons were demonstrated, and the reasons that caused these differences were also explored in the context of their relations to the changes in water quality. Consequently, water environment condition could be revealed by using the inherent optical property. The relationship between the backscattering coefficient and the TSM concentration was established, which could provide supporting coefficients to the analytical models to be developed.

  11. Extraction of Urban Water Bodies from High-Resolution Remote-Sensing Imagery Using Deep Learning

    Directory of Open Access Journals (Sweden)

    Yang Chen

    2018-05-01

    Full Text Available Accurate information on urban surface water is important for assessing the role it plays in urban ecosystem services in the context of human survival and climate change. The precise extraction of urban water bodies from images is of great significance for urban planning and socioeconomic development. In this paper, a novel deep-learning architecture is proposed for the extraction of urban water bodies from high-resolution remote sensing (HRRS imagery. First, an adaptive simple linear iterative clustering algorithm is applied for segmentation of the remote-sensing image into high-quality superpixels. Then, a new convolutional neural network (CNN architecture is designed that can extract useful high-level features of water bodies from input data in a complex urban background and mark the superpixel as one of two classes: an including water or no-water pixel. Finally, a high-resolution image of water-extracted superpixels is generated. Experimental results show that the proposed method achieved higher accuracy for water extraction from the high-resolution remote-sensing images than traditional approaches, and the average overall accuracy is 99.14%.

  12. Drugs: Between Regulated Bodies and Deviant Morals. Argentina, 1880-1960

    Directory of Open Access Journals (Sweden)

    Victoria Sánchez Antelo

    2018-01-01

    Full Text Available The article examines the ways in which the “phenomenon of drugs” was discussed, defined, and addressed in Argentina between 1880 and 1960. It focuses on two central themes: the local political debates regarding the uses, regulation, and penalization of drugs, and the manner in which the practices, subjects, and social contexts related to drugs are conceptualized from the perspective of psychopathology and local criminology. Despite the fact that they were influenced by the guidelines of international entities and currents of thought, both of these processes feature a specific local dynamic that results in policies aimed at the control of bodies and populations, as well as in moral systems of classification of subjects and practices.

  13. Identification of Water Bodies in a Landsat 8 OLI Image Using a J48 Decision Tree.

    Science.gov (United States)

    Acharya, Tri Dev; Lee, Dong Ha; Yang, In Tae; Lee, Jae Kang

    2016-07-12

    Water bodies are essential to humans and other forms of life. Identification of water bodies can be useful in various ways, including estimation of water availability, demarcation of flooded regions, change detection, and so on. In past decades, Landsat satellite sensors have been used for land use classification and water body identification. Due to the introduction of a New Operational Land Imager (OLI) sensor on Landsat 8 with a high spectral resolution and improved signal-to-noise ratio, the quality of imagery sensed by Landsat 8 has improved, enabling better characterization of land cover and increased data size. Therefore, it is necessary to explore the most appropriate and practical water identification methods that take advantage of the improved image quality and use the fewest inputs based on the original OLI bands. The objective of the study is to explore the potential of a J48 decision tree (JDT) in identifying water bodies using reflectance bands from Landsat 8 OLI imagery. J48 is an open-source decision tree. The test site for the study is in the Northern Han River Basin, which is located in Gangwon province, Korea. Training data with individual bands were used to develop the JDT model and later applied to the whole study area. The performance of the model was statistically analysed using the kappa statistic and area under the curve (AUC). The results were compared with five other known water identification methods using a confusion matrix and related statistics. Almost all the methods showed high accuracy, and the JDT was successfully applied to the OLI image using only four bands, where the new additional deep blue band of OLI was found to have the third highest information gain. Thus, the JDT can be a good method for water body identification based on images with improved resolution and increased size.

  14. C. elegans serine-threonine kinase KIN-29 modulates TGFβ signaling and regulates body size formation

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    Cohen Stephen

    2005-04-01

    Full Text Available Background In C. elegans there are two well-defined TGFβ-like signaling pathways. The Sma/Mab pathway affects body size morphogenesis, male tail development and spicule formation while the Daf pathway regulates entry into and exit out of the dauer state. To identify additional factors that modulate TGFβ signaling in the Sma/Mab pathway, we have undertaken a genetic screen for small animals and have identified kin-29. Results kin-29 encodes a protein with a cytoplasmic serine-threonine kinase and a novel C-terminal domain. The kinase domain is a distantly related member of the EMK (ELKL motif kinase family, which interacts with microtubules. We show that the serine-threonine kinase domain has in vitro activity. kin-29 mutations result in small animals, but do not affect male tail morphology as do several of the Sma/Mab signal transducers. Adult worms are smaller than the wild-type, but also develop more slowly. Rescue by kin-29 is achieved by expression in neurons or in the hypodermis. Interaction with the dauer pathway is observed in double mutant combinations, which have been seen with Sma/Mab pathway mutants. We show that kin-29 is epistatic to the ligand dbl-1, and lies upstream of the Sma/Mab pathway target gene, lon-1. Conclusion kin-29 is a new modulator of the Sma/Mab pathway. It functions in neurons and in the hypodermis to regulate body size, but does not affect all TGFβ outputs, such as tail morphogenesis.

  15. Simulation model of pollution spreading in the water bodies affected by mining mill

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    Kalinkina Natalia Mikhailovna

    2015-09-01

    Full Text Available Water bodies of the northern Karelia are polluted by liquid wastes of Kostomukshsky iron ore-dressing mill. The main components of these wastes are potassium ions. The processes of the potassium spreading in lake-river system of the River Kenty were studied using simulation modeling. For water bodies, where chemical observations were not carried out, the reconstruction of data was realized. The parameters of the model (constants of potassium transfer for seven lakes were calculated. These constants reflect the hydrological regime of water bodies and characterize high-speed transfer of potassium in the upstream and downstream, and low transfer rate - in the middle stream. It is shown that the vast majority of potassium (70% is carried out of the system Kenty and enters the lake Srednee Kuito

  16. An artificial water body provides habitat for an endangered estuarine seahorse species

    Science.gov (United States)

    Claassens, Louw

    2016-10-01

    Anthropogenic development, especially the transformation of natural habitats to artificial, is a growing concern within estuaries and coastal areas worldwide. Thesen Islands marina, an artificial water body, added 25 ha of new estuarine habitat to the Knysna Estuary in South Africa, home to the Knysna seahorse. This study aimed to answer: (I) Can an artificial water body provide suitable habitat for an endangered seahorse species? And if so (II) what characteristics of this new habitat are important in terms of seahorse utilization? Four major habitat types were identified within the marina canals: (I) artificial reno mattress (wire baskets filled with rocks); (II) Codium tenue beds; (III) mixed vegetation on sediment; and (IV) barren canal floor. Seahorses were found throughout the marina system with significantly higher densities within the reno mattress habitat. The artificial water body, therefore, has provided suitable habitat for Hippocampus capensis, a noteworthy finding in the current environment of coastal development and the increasing shift from natural to artificial.

  17. Why does it matter how we regulate the use of human body parts?

    Science.gov (United States)

    Goold, Imogen

    2014-01-01

    Human tissue and body parts have been used in one way or another for millennia. They have been preserved and displayed, both in museums and public shows. Real human hair is used for wigs, while some artists even use human tissue in their works. Blood, bone marrow, whole organs and a host of other structures and human substances are all transplanted into living persons to treat illness. New life can be created from gametes through in vitro fertilisation (IVF), while the creation of cell lines keeps tissue alive indefinitely. These uses create significant challenges for the legal system in the UK. The major challenge for the law is to balance the competing demands of those groups who have vested interests in human tissue-researchers, medical practitioners, patients, families, the community and the police, among many others. It must provide sufficient control to users of tissue, but also take account of the fact that our bodies hold psychological importance for us while we live and, after we die, for those we leave behind. To some degree the law has been successful, but we still lack a comprehensive, coherent approach to the regulation of human tissue. Partially as a reaction to this lack of a comprehensive approach, some commentators have turned to applying the concept of property to human tissue means to achieve regulatory outcomes they support.

  18. Alpha-lipoic acid reduces body weight and regulates triglycerides in obese patients with diabetes mellitus.

    Science.gov (United States)

    Okanović, Azra; Prnjavorac, Besim; Jusufović, Edin; Sejdinović, Rifat

    2015-08-01

    To determine an influence of alpha-lipoic acid to reduction of body weight and regulation of total cholesterol concentration, triglycerides and glucose serum levels in obese patients with diabetes mellitus type 2. A prospective study includes two groups of obese patients with diabetes mellitus and signs of peripheral polyneuropathia: examined group (30 patients; 15 females and 15 males), and control group (30 patients; 12 females and 18 males). All were treated with metformin (850-1700 mg/day). Examined patients were additionally treated with alpha-lipoic acid 600 mg/day during 20 weeks. Body mass index and concentrations of total cholesterol, triglycerides and glucose in serum were compared before and after the treatment. The group treated with 600 mg alpha-lipoic acid lost significantly more weight, and had lower triglyceride level than the control group. There were no significant differences in total cholesterol and glucose serum levels between the groups. Alpha-lipoic acid of 600 mg/day treatment have influenced weight and triglycerides loss in obese patients with diabetes mellitus type 2. It should be considered as an important additive therapy in obese patients with diabetes mellitus type 2. Copyright© by the Medical Assotiation of Zenica-Doboj Canton.

  19. Body weight and ADHD: examining the role of self-regulation.

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    Zia Choudhry

    Full Text Available Attention-Deficit/Hyperactivity Disorder (ADHD is a complex and heterogeneous childhood disorder that often coexists with other psychiatric and somatic disorders. Recently, a link between ADHD and body weight dysregulation has been reported and often interpreted as impaired self-regulation that is shared between the two conditions. The objective of this study is to investigate the relation between body weight/BMI and cognitive, emotional and motor characteristics in children with ADHD.284 ADHD children were stratified by weight status/BMI according to WHO classification and compared with regard to their neurocognitive characteristics, motivational style, and motor profile as assessed by a comprehensive battery of tests. All comparisons were adjusted for demographic characteristics of relevance including, socioeconomic status (SES.Both Obese and overweight ADHD children exhibited significantly lower SES compared to normal weight ADHD children. No significant differences were observed between the three groups with regards to their neurocognitive, emotional and motor profile.Our findings provide evidence that differences in weight/BMI are not accounted for by cognitive, motivational and motor profiles. Socio-economic characteristics are strongly associated with overweight and obesity in ADHD children and may inform strategies aimed at promoting healthier weight.

  20. iCub Whole-body Control through Force Regulation on Rigid Noncoplanar Contacts

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    Francesco eNori

    2015-03-01

    Full Text Available This paper details the implementation on the humanoid robot iCub of state-of-the-art algorithms for whole-body control. We regulate the forces between the robot and its surrounding environment to stabilize a desired robot posture. We assume that the forces and torques are exerted on rigid contacts. The validity of this assumption is guaranteed by constraining the contact forces and torques, e.g. the contact forces must belong to the associated friction cones. The implementation of this control strategy requires to estimate the external forces acting on the robot, and the internal joint torques. We then detail algorithms to obtain these estimations when using a robot with an iCub-like sensor set, i.e. distributed six-axis force-torque sensors and whole-body tactile sensors. A general theory for identifying the robot inertial parameters is also presented. From an actuation standpoint, we show how to implement a joint torque control in the case of DC brushless motors. In addition, the coupling mechanism of the iCub torso is investigated. The soundness of the entire control architecture is validated in a real scenario involving the robot iCub balancing and making contacts at both arms.

  1. Central and peripheral des-acyl ghrelin regulates body temperature in rats.

    Science.gov (United States)

    Inoue, Yoshiyuki; Nakahara, Keiko; Maruyama, Keisuke; Suzuki, Yoshiharu; Hayashi, Yujiro; Kangawa, Kenji; Murakami, Noboru

    2013-01-04

    In the present study using rats, we demonstrated that central and peripheral administration of des-acyl ghrelin induced a decrease in the surface temperature of the back, and an increase in the surface temperature of the tail, although the effect of peripheral administration was less marked than that of central administration. Furthermore, these effects of centrally administered des-acyl ghrelin could not be prevented by pretreatment with [D-Lys3]-GHRP-6 GH secretagogue receptor 1a (GHS-R1a) antagonists. Moreover, these actions of des-acyl ghrelin on body temperature were inhibited by the parasympathetic nerve blocker methylscopolamine but not by the sympathetic nerve blocker timolol. Using immunohistochemistry, we confirmed that des-acyl ghrelin induced an increase of cFos expression in the median preoptic nucleus (MnPO). Additionally, we found that des-acyl ghrelin dilated the aorta and tail artery in vitro. These results indicate that centrally administered des-acyl ghrelin regulates body temperature via the parasympathetic nervous system by activating neurons in the MnPO through interactions with a specific receptor distinct from the GHS-R1a, and that peripherally administered des-acyl ghrelin acts on the central nervous system by passing through the blood-brain barrier, whereas it exerts a direct action on the peripheral vascular system. Copyright © 2012 Elsevier Inc. All rights reserved.

  2. The effective dose and pattern of soybean extract administration to regulate body weight of laboratory rats

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    Meilinah Hidayat

    2016-07-01

    the intake of protein and suppress appetite for short-term. Detam 1 variety is a high-quality soybean according to the Minister of Agriculture of Indonesia. Soybean protein extract Detam 1 by Deak method contains high levels of β conglycinin. The purpose of this study was to determine the effective dose of protein extract Detam 1 soybean Deak Method (PEDSDM in reducing food intake, regulate body weight, and plasma CCK level for 14 and 28 days at various dosage and pattern of treatment on male Wistar rats. Methods: There were eleven groups of treatment (n = 3, administrated with extracts at 5 mg/1x/day, 10 mg/1x/day, 20 mg/1x/day, 2.5 mg/2x/day, 5 mg/2x/day, 10 mg/2x/day and 1.7mg/3x/day, 3.4mg/3x/day, 6.7 mg/3x/day, negative control group (distilled water and positive control group (Sibutramine. Food intake (g, weight loss (g and measurement of plasma Cholecystokinin levels by ELISA (ng /ml Results: The results showed that the highest percentage decrease in food intake is: group 3.4mg /3x/ day (p <0.05, inhibition weight gain for 14 days: group 10 mg /1x/ day, for 28 days: group 1.7 mg/3x/day (p <0.05, increased plasma Cholecystokinin levels: group 20 mg /1x/day (p <0.05. Conclusions: The effective dose and pattern administrating the rats for 14 days is extract of 10 mg once a day in the morning, for 28 days is 1.7 mg three times a day. (Health Science Journal of Indonesia 2016;7:17-26 Keywords: Soybean var Detam 1 -effective dose - body weight - Cholecystokinin 

  3. Water level influences on body condition of Geophagus brasiliensis (Perciformes: Cichlidae in a Brazilian oligotrophic reservoir

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    Alejandra Filippo Gonzalez Neves dos Santos

    Full Text Available Effects of water level fluctuations on body condition of Geophagus brasiliensis were studied in a 30 km² Brazilian oligotrophic reservoir. Physiological condition (K and gonadosomatic index (GSI were compared according to water level (low and high. Females' best conditions were associated to higher resources availability during high water, since gonad development did not change between low and high water. Males' condition did not change between water levels, while the highest gonad development occurred in low water. Females presented higher reproductive investment than males, which allocated most of energy for somatic development. This strategy could be a mechanism to undergo the stress caused by oligotrophic characteristics of the reservoir enhanced during low water level.

  4. Comparative analysis of doses to aquatic biota in water bodies impacted by radioactive contamination

    International Nuclear Information System (INIS)

    Kryshev, A.I.; Sazykina, T.G.

    2012-01-01

    Comparative analysis of doses to the reference species of freshwater biota was performed for the following water bodies in Russia or former USSR: Chernobyl NPPs cooling pond, Lakes Uruskul and Berdenish located in the Eastern Urals Radioactive Trace, Techa River, Yenisei River. It was concluded that the doses to biota were considerably different in the acute and chronic periods of radioactive contamination. The most vulnerable part of all considered aquatic ecosystems was benthic trophic chain. A numerical scale on the “dose rate – effects” relationships for fish was formulated. Threshold dose rates above which radiation effects can be expected in fish were evaluated to be the following: 1 mGy d −1 for appearance of the first morbidity effects in fish; 5 mGy d −1 for the first negative effects on reproduction system; 10 mGy d −1 for the first effects on life shortening of fish. The results of dose assessment to biota were compared with the scale “dose rate – effects” and the literature data on the radiobiological effects observed in the considered water bodies. It was shown that in the most contaminated water bodies the dose rates were high enough to cause the radiobiological effects in fish. - Highlights: ► Comparative analysis of dose rates to biota in different water bodies was performed. ► A numerical scale on the dose rates – effects relationships for fish was formulated. ► Results of assessment of exposure to biota were compared with the dose rates – effects scale. ► In the most contaminated water bodies the doses were high enough to cause radiobiological effects in fish. ► Current dose rates to biota in all considered water bodies are below the safety level of 1 mGy/day.

  5. A conserved role for syndecan family members in the regulation of whole-body energy metabolism.

    Directory of Open Access Journals (Sweden)

    Maria De Luca

    2010-06-01

    syndecan family members play a key role in the regulation of body metabolism.

  6. Certain requirements to surface water quality and monitoring of water bodies in the EU

    OpenAIRE

    Storchak T. V.; Pogonysheva I. A.; Ryabukha A. V.; Arishev A. I.

    2018-01-01

    Water pollution has become a pressing issues in the European Union. EU Water protection legislature plays major role in the development of national policies in many of the EU countries. EU is currently implementing Water Framework Directive. The Directive demonstrates an innovative approach to water resources management based on river basins. According to the Directive, EU countries take a responsibility to prevent further deterioration and make effort to restore and improve the state of wate...

  7. The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body.

    Directory of Open Access Journals (Sweden)

    Christal A Worthen

    2014-03-01

    Full Text Available Fine tuning of body iron is required to prevent diseases such as iron-overload and anemia. The putative iron-sensor, transferrin receptor 2 (TfR2, is expressed in the liver and mutations in this protein result in the iron-overload disease Type III hereditary hemochromatosis (HH. With the loss of functional TfR2, the liver produces about two-fold less of the peptide hormone hepcidin, which is responsible for negatively regulating iron uptake from the diet. This reduction in hepcidin expression leads to the slow accumulation of iron in the liver, heart, joints, and pancreas and subsequent cirrhosis, heart disease, arthritis, and diabetes. TfR2 can bind iron-loaded transferrin in the bloodstream, and hepatocytes treated with transferrin respond with a two-fold increase in hepcidin expression through stimulation of the BMP-signaling pathway. Loss of functional TfR2 or its binding partner, the original HH protein (HFE, results in a loss of this transferrin-sensitivity. While much is known about the trafficking and regulation of TfR2, the mechanism of its transferrin-sensitivity through the BMP-signaling pathway is still not known.

  8. When land breezes collide: Converging diurnal winds over small bodies of water

    OpenAIRE

    Gille, ST; Llewellyn Smith, SG

    2014-01-01

    © 2013 Royal Meteorological Society. Over enclosed and semi-enclosed bodies of water, the land-breeze/sea-breeze circulation is expected to be modified by the presence of opposing coastlines. These effects are studied using satellite scatterometer surface wind observations from the QuikSCAT and ADEOS-2 tandem mission from April-October 2003. Winds are studied for six bodies of water: the Red Sea, the Gulf of California, the Mediterranean, the Adriatic Sea, the Black Sea and the Caspian Sea. T...

  9. Radionuclide transport in the "sediments - water - plants" system of the water bodies at the Semipalatinsk test site.

    Science.gov (United States)

    Aidarkhanova, A K; Lukashenko, S N; Larionova, N V; Polevik, V V

    2018-04-01

    This paper provides research data on levels and character of radionuclide contamination distribution in the «sediments- water - plants » system of objects of the Semipalatinsk test site (STS). As the research objects there were chosen water bodies of man-made origin which located at the territory of "Experimental Field", "Balapan", "Telkem" and "Sary-Uzen" testing sites. For research the sampling of bottom sediments, water, lakeside and water plants was taken. Collected samples were used to determine concentration of anthropogenic radionuclides 90 Sr, 239+240 Pu, 241 Am, 137 Cs. The distribution coefficient (K d ) was calculated as the ratio of the content of radionuclides in the sediments to the content in water, and the concentration ratio (F V ) was calculated as the ratio of radionuclide content in plants to the content in sediments or soil. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. Infrared and Raman Spectroscopy of Liquid Water through "First-Principles" Many-Body Molecular Dynamics.

    Science.gov (United States)

    Medders, Gregory R; Paesani, Francesco

    2015-03-10

    Vibrational spectroscopy is a powerful technique to probe the structure and dynamics of water. However, deriving an unambiguous molecular-level interpretation of the experimental spectral features remains a challenge due to the complexity of the underlying hydrogen-bonding network. In this contribution, we present an integrated theoretical and computational framework (named many-body molecular dynamics or MB-MD) that, by systematically removing uncertainties associated with existing approaches, enables a rigorous modeling of vibrational spectra of water from quantum dynamical simulations. Specifically, we extend approaches used to model the many-body expansion of interaction energies to develop many-body representations of the dipole moment and polarizability of water. The combination of these "first-principles" representations with centroid molecular dynamics simulations enables the simulation of infrared and Raman spectra of liquid water under ambient conditions that, without relying on any ad hoc parameters, are in good agreement with the corresponding experimental results. Importantly, since the many-body energy, dipole, and polarizability surfaces employed in the simulations are derived independently from accurate fits to correlated electronic structure data, MB-MD allows for a systematic analysis of the calculated spectra in terms of both electronic and dynamical contributions. The present analysis suggests that, while MB-MD correctly reproduces both the shifts and the shapes of the main spectroscopic features, an improved description of quantum dynamical effects possibly combined with a dissociable water potential may be necessary for a quantitative representation of the OH stretch band.

  11. Water Quality Dynamics of Urban Water Bodies during Flooding in Can Tho City, Vietnam

    Directory of Open Access Journals (Sweden)

    Hong Quan Nguyen

    2017-04-01

    Full Text Available Water pollution associated with flooding is one of the major problems in cities in the global South. However, studies of water quality dynamics during flood events are not often reported in literature, probably due to difficult conditions for sampling during flood events. Water quality parameters in open water (canals, rivers, and lakes, flood water on roads and water in sewers have been monitored during the extreme fluvial flood event on 7 October 2013 in the city of Can Tho, Vietnam. This is the pioneering study of urban flood water pollution in real time in Vietnam. The results showed that water quality is very dynamic during flooding, especially at the beginning of the event. In addition, it was observed that the pathogen and contaminant levels in the flood water are almost as high as in sewers. The findings show that population exposed to flood water runs a health risk that is nearly equal to that of being in contact with sewer water. Therefore, the people of Can Tho not only face physical risk due to flooding, but are also exposed to health risks.

  12. Study of Chironomidae Natural Populations of the Former Semipalatinsk Test Site Water Bodies

    International Nuclear Information System (INIS)

    Aimanova, K.G.; Blinov, A.G.; Kiknadze, I.I.; Bakhtin, M.M.; Seisebaev, A.T.; Rakhimbaeva, K.T.

    1998-01-01

    The open water bodies as a component of the biosphere serve as the accumulators of artificial radionuclides generated during the nuclear explosions; therefore their radioactive contamination needs to be registered. The assessment of the environmental radioactive contamination consequences for the natural populations of organisms living in water bodies is of particular importance. Chironomini (Diptera, Chironomidae) play an important role as they are a significant component of water and air biocenoses and provide the self-cleaning of water bodies and food chains of industrial fish and bird. Chironomini have been chosen to be a model for the UNESCO International Program titled 'Man and Biosphere' and are used as the biologic indicator for ecological studies of anthropogenic influence on water bodies. The study of Chironomini natural mutagenic process and its alteration due to the radioactive contamination of water bodies is of extreme scientific interest and can serve as the indicator of the scale of genetic damage of water organisms. This work presents the data on natural populations of Chironomini of former STS water bodies: Shagan Lake, Balapan Lake, the artificial water body on the Karazhyra Coal Field, the backwater near the Shagan River, Balykty col Lake, etc. The analysis of morphology and caryotype of Camptochironomus sp. S (S - larvae have been sampled from the Semipalatinsk Test Site) showed that this is a new species as compared to studied species (C. tentans, C. pallidivittatus) of Camptochironomus subfamily. The caryotype Camptochironomus sp. S differs sharply from the caryotypes of other Camptochironomus species due to its strong hetero chromatization of centromeric discs. The immediate molecular analysis of genome DNA of Camptochironomus sp. S larvae sampled from Shagan Lake was performed: the total DNA of larvae of this species was obtained, nucleonic sequences of genes of cytochrome B (Cyt B) and cytochrome I (COI) were determined using methods of

  13. Carbamazepine as a Possible Anthropogenic Marker in Water: Occurrences, Toxicological Effects, Regulations and Removal by Wastewater Treatment Technologies

    Directory of Open Access Journals (Sweden)

    Faisal I. Hai

    2018-01-01

    Full Text Available Carbamazepine (CBZ, a pharmaceutical compound, has been proposed as an anthropogenic marker to assess water quality due to its persistence in conventional treatment plants and widespread presence in water bodies. This paper presents a comprehensive literature review on sources and occurrences of CBZ in water bodies, as well as toxicological effects and regulations of the drug. Given the documented side effects of CBZ on the human body when taken medicinally, its careful monitoring in water is recommended. CBZ residues in drinking water may provide a pathway to embryos and infants via intrauterine exposure or breast-feeding, which may cause congenital malformations and/or neurodevelopmental problems over long term exposure. An in-depth technical assessment of the conventional and advanced treatment technologies revealed the inadequacy of the standalone technologies. Compared to conventional activated sludge and membrane bioreactor processes, effective removal of CBZ can be achieved by nanofiltration and reverse osmosis membranes. However, recent studies have revealed that harsh chemical cleaning, as required to mitigate membrane fouling, can often reduce the long-term removal efficiency. Furthermore, despite the efficient performance of activated carbon adsorption and advanced oxidation processes, a few challenges such as cost of chemicals and regeneration of activated carbon need to be carefully considered. The limitations of the individual technologies point to the advantages of combined and hybrid systems, namely, membrane bioreactor coupled with nanofiltration, adsorption or advanced oxidation process.

  14. Analysis of key thresholds leading to upstream dependencies in global transboundary water bodies

    Science.gov (United States)

    Munia, Hafsa Ahmed; Guillaume, Joseph; Kummu, Matti; Mirumachi, Naho; Wada, Yoshihide

    2017-04-01

    Transboundary water bodies supply 60% of global fresh water flow and are home to about 1/3 of the world's population; creating hydrological, social and economic interdependencies between countries. Trade-offs between water users are delimited by certain thresholds, that, when crossed, result in changes in system behavior, often related to undesirable impacts. A wide variety of thresholds are potentially related to water availability and scarcity. Scarcity can occur because of the country's own water use, and that is potentially intensified by upstream water use. In general, increased water scarcity escalates the reliance on shared water resources, which increases interdependencies between riparian states. In this paper the upstream dependencies of global transboundary river basins are examined at the scale of sub-basin areas. We aim to assess how upstream water withdrawals cause changes in the scarcity categories, such that crossing thresholds is interpreted in terms of downstream dependency on upstream water availability. The thresholds are defined for different types of water availability on which a sub-basin relies: - reliable local runoff (available even in a dry year), - less reliable local water (available in the wet year), - reliable dry year inflows from possible upstream area, and - less reliable wet year inflows from upstream. Possible upstream withdrawals reduce available water downstream, influencing the latter two water availabilities. Upstream dependencies have then been categorized by comparing a sub-basin's scarcity category across different water availability types. When population (or water consumption) grows, the sub-basin satisfies its needs using less reliable water. Thus, the factors affecting the type of water availability being used are different not only for each type of dependency category, but also possibly for every sub- basin. Our results show that, in the case of stress (impacts from high use of water), in 104 (12%) sub- basins out of

  15. Residual volume on land and when immersed in water: effect on percent body fat.

    Science.gov (United States)

    Demura, Shinichi; Yamaji, Shunsuke; Kitabayashi, Tamotsu

    2006-08-01

    There is a large residual volume (RV) error when assessing percent body fat by means of hydrostatic weighing. It has generally been measured before hydrostatic weighing. However, an individual's maximal exhalations on land and in the water may not be identical. The aims of this study were to compare residual volumes and vital capacities on land and when immersed to the neck in water, and to examine the influence of the measurement error on percent body fat. The participants were 20 healthy Japanese males and 20 healthy Japanese females. To assess the influence of the RV error on percent body fat in both conditions and to evaluate the cross-validity of the prediction equation, another 20 males and 20 females were measured using hydrostatic weighing. Residual volume was measured on land and in the water using a nitrogen wash-out technique based on an open-circuit approach. In water, residual volume was measured with the participant sitting on a chair while the whole body, except the head, was submerged . The trial-to-trial reliabilities of residual volume in both conditions were very good (intraclass correlation coefficient > 0.98). Although residual volume measured under the two conditions did not agree completely, they showed a high correlation (males: 0.880; females: 0.853; P body fat computed using residual volume measured in both conditions was very good for both sexes (males: r = 0.902; females: r = 0.869, P body fat: -3.4 to 2.2% for males; -6.3 to 4.4% for females). We conclude that if these errors are of no importance, residual volume measured on land can be used when assessing body composition.

  16. Water ages of 20 groundwater bodies and its relevance for the implementation of the European Water Framework Directive

    Science.gov (United States)

    Kralik, Martin; Brielmann, Heike; Humer, Franko; Grath, Johannes; Sültenfuß, Jürgen; Philippitsch, Rudolf

    2015-04-01

    The 'Mean Residence Time' (MRT) of groundwater is required to develop reliable hydrogeological concepts of groundwater bodies as a prerequisite for a qualified monitoring and risk assessment. MRTs from monitoring wells help to assess if groundwater bodies are 'at risk' or 'not at risk' failing to meet good groundwater quantitative and chemical status according to the Water Framework Directive and therefore not being able to use the groundwater as drinking water or industrial water resource. A combination of 18O/2H, 3H, 3H/3He and in some cases additional CFC, SF6, 85Kr and 35S measurements allow to calculate reliable MRTs in 20 groundwater bodies covering 13% (approx.10719 km2) of the Austrian territory. Altogether 401 groundwater wells and springs from the existing groundwater monitoring network were analysed for δ18O (n=1500), 3H (n=800) and 3He (n=327) since 2006. Considering both the fact that monitoring wells may have multiple or long well screens and the inherent uncertainties of groundwater age dating techniques, age estimations were classified into 5 categories of short ( 50years) mean residence times for each monitoring site. Subsequently, median values of the MRT categories were assigned to each investigated groundwater body. These are valuable information to fix extraction rates, to set measures to improve the land use and groundwater protection and to validate hydrogeological concepts. Generally, MRTs of groundwater bodies increase from shallow Alpine groundwater bodies over deeper Alpine valley-aquifers to longer MRTs in the Pannonian climate range in the east of Austria.

  17. Water temperature, body mass and fasting heat production of pacu (Piaractus mesopotamicus).

    Science.gov (United States)

    Aguilar, Fredy A A; Cruz, Thaline M P DA; Mourão, Gerson B; Cyrino, José Eurico P

    2017-01-01

    Knowledge on fasting heat production (HEf) of fish is key to develop bioenergetics models thus improving feeding management of farmed species. The core of knowledge on HEf of farmed, neotropical fish is scarce. This study assessed the effect of body mass and water temperature on standard metabolism and fasting heat production of pacu, Piaractus mesopotamicus, an omnivore, Neotropical fresh water characin important for farming and fisheries industries all through South American continent. An automated, intermittent flow respirometry system was used to measure standard metabolic rate (SMR) of pacu (17 - 1,050 g) at five water temperatures: 19, 23, 26, 29 and 33 °C. Mass specific SMR increased with increasing water temperature but decreased as function of body mass. The allometric exponent for scaling HEf was 0.788, and lied in the range recorded for all studied warm-water fish. The recorded van't Hoff factor (Q10) for pacu (2.06) shows the species low response to temperature increases. The model HEf = 0.04643×W0.7882×T1.837 allows to predict HEf (kJ d-1) from body mass (W, kg) and water temperature (T, °C), and can be used in bioenergetical models for the species.

  18. Pythium species in 13 various types of water bodies of N-E Poland

    Directory of Open Access Journals (Sweden)

    Bazyli Czeczuga

    2014-01-01

    Full Text Available Pythium species and environmental factors in various types of water bodies (2 springs, 2 rivers, 3 ponds and 6 different trophic lakes were studied. Samples of water were collected every two months (springs, rivers, ponds and every three months (lakes in the years 1996-1999 for hydrochemical analysis and in order to determine the Pythium species content. From springs rivers and ponds collected were also ice blocks for determinations of presence of Pythium species. Buckwheatand hemp-seeds, cellophane and snake exuviae were used as bait. Forty-five species of Pythium were found in various types of water bodies. Pythium acanthicum, P. complectens, P. complens, P. diameson, P. dissimile, P. elongatum, P. lucens, P. megalacanthum, P. nagae, P. oedochilum, P. oryzae, P. palingenes, P. periilum and P. polysporum were recorded for the first time in Poland. The largest mean number of species was observed in spring Cypisek, a bit fewer in spring Jaroszówka and lake Białe (oligotrophic-like waters. The lowest mean number of Pythium species was noted in pond Akcent and Pałacowy (polytrophic waters. In all types of water bodies the higest mean number of species was found in winter, and the lowest in summer.

  19. Water temperature, body mass and fasting heat production of pacu (Piaractus mesopotamicus

    Directory of Open Access Journals (Sweden)

    FREDY A.A. AGUILAR

    Full Text Available ABSTRACT Knowledge on fasting heat production (HEf of fish is key to develop bioenergetics models thus improving feeding management of farmed species. The core of knowledge on HEf of farmed, neotropical fish is scarce. This study assessed the effect of body mass and water temperature on standard metabolism and fasting heat production of pacu, Piaractus mesopotamicus, an omnivore, Neotropical fresh water characin important for farming and fisheries industries all through South American continent. An automated, intermittent flow respirometry system was used to measure standard metabolic rate (SMR of pacu (17 - 1,050 g at five water temperatures: 19, 23, 26, 29 and 33 °C. Mass specific SMR increased with increasing water temperature but decreased as function of body mass. The allometric exponent for scaling HEf was 0.788, and lied in the range recorded for all studied warm-water fish. The recorded van't Hoff factor (Q10 for pacu (2.06 shows the species low response to temperature increases. The model HEf = 0.04643×W0.7882×T1.837 allows to predict HEf (kJ d-1 from body mass (W, kg and water temperature (T, °C, and can be used in bioenergetical models for the species.

  20. Sprectroradiometric characteristics of inland water bodies infestated by Oscillatoria rubescens algae

    Science.gov (United States)

    Ciraolo, Giuseppe; La Loggia, Goffredo; Maltese, Antonino

    2010-10-01

    In December 2006 blooms of Oscillatoria rubescens were found in the reservoir Prizzi in Sicily. Oscillatoria is a genus of filamentous alga comprising approximately 6 species, between these the O. rubescens is sadly famous since this organism produces microcystins which are powerful hepatotoxins. Firstly found in Europe in 1825 on Geneva lake, recently (2006) those algae has been find out in Pozzillo, Nicoletti e Ancipa reservoirs (Enna Province), as well as in Prizzi (Palermo Province) and Garcia reservoirs (Trapani Province). Toxins produced by those bacteria (usually called microcystine LR-1 and LR-2) are highly toxic since they can activate oncogenes cells causing cancer pathologies on liver and gastrointestinal tract. Even if water treatment plants should ensure the provision of safe drinking water from surface waters contaminated with those toxic algae blooms, the contamination of reservoirs used for civil and agricultural supply highlights human health risks. International literature suggests a threshold value of 0.01 μgl-1 to avoid liver cancer using water coming from contaminated water bodies for a long period. Since O. rubescens activities is strongly related to phosphate and nitrogen compounds as well as to temperature and light transmission within water, the paper presents the comparison between optical properties of the water of an infested reservoir and those of a reservoir characterized by clear water. Field campaigns were carried out in February-March 2008 in order to quantify the spectral transparencies of two water bodies through the calculation of the diffuse attenuation coefficient, measuring underwater downwelling irradiance at different depths as well as water spectral reflectance. Results show that diffuse attenuation coefficient is reduced by approximately 15% reducing light penetration in the water column; coherently reflectance spectral signature generally decreases, exhibiting a characteristic peak around 703 nm not present in

  1. Indexes of the common reed's seed vitality from water-bodies of the Chernobyl exclusive zone

    International Nuclear Information System (INIS)

    Yavnuk, A.A.; Shevtsova, N.L.; Gudkov, D.I.; Levchenko, Ya.I.

    2010-01-01

    Investigation of the common reed's seed vitality (vegetation of 2009) from flood-plain water-bodies with different level of radionuclide contamination was carried out. Decrease in indexes of seed's vitality and abnormalities in seed dynamic sprouting was noticed. Dose-response relationship of germination, germinating force, survival rate of seeds of plants was determined. (authors)

  2. Sensitivity to Disgust and Perceptions of Natural Bodies of Water and Watercraft Activities

    Science.gov (United States)

    Robert D. Bixler; Gwynn Powell

    2003-01-01

    A written 7-item self-report scale on sensitivity to disgust and participation in watercraft activities was administered to 450 seasonal park employees. Correlations indicate that nonparticipation in seven different watercraft sports was weakly related with reactions of disgust to contact with natural bodies of water (rpbis...

  3. Effects of whole body cryotherapy and cold water immersion on knee skin temperature

    OpenAIRE

    Costello, J. T.; Donnelly, A. E.; Karki, A.; Selfe, J.

    2014-01-01

    This study sought to a) compare and contrast the effect of 2 commonly used cryotherapy treatments, 4 min of −110°C whole body cryotherapy and 8°C cold water immersion, on knee skin temperature and b) establish whether either protocol was capable of achieving a skin temperature (

  4. SOME INSIGHTS REGARDING CREATIVE ACCOUNTING IN ROMANIAN ACCOUNTING ENVIRONMENT - REGULATORS, FINANCIAL AUDITORS AND PROFESSIONAL BODIES OPINION

    Directory of Open Access Journals (Sweden)

    Grosanu Adrian

    2011-07-01

    Full Text Available This empirical study reports the results of a survey designed to explore the existence and magnitude of creative accounting practices in the Romanian accounting environment using as a reference point the opinion of some of the top representative accounting professionals like: financial auditors, regulators and professional bodies representatives of the Chamber of Financial Auditors of Romania and also representative of the Body of Expert and Licensed Accountants of Romania. Since the existence of creative accounting practices are connected in accounting with issues of vulnerability and in some cases panic getting to know its magnitude can be regarded of higher importance. In this respect we were interested to see if our respondents can document its existence and magnitude based on their experience. In order to achieve this goal our methodology employed neutral and direct interviews based on closed questions questionnaire. The results of our empirical study documented that the credibility of accounting profession in the Romanian accounting environment is not affected by items like creative accounting since all our respondents asserted that is not facile to employ creative accounting schemes in the practice of accounting. One particular question was concerned about the ease of detection of creative accounting practices. In this respect we interrogated our respondents and all had similar opinions that in order to detect those practice skilled professionals are needed and more than that the desire to engage in this demarche since it is not specified particularly in the law.When it comes to creative accounting schemes that our respondents could identify in their day to day work they shared similar views: items like profit overstatement and profit undervaluation, income tax and leasing can be included frequently in those schemes. On the other hand practices of creative accounting that include goodwill, provisions and developments costs are not found

  5. Distribution and Ecology of Cyanobacteria in the Rocky Littoral of an English Lake District Water Body, Devoke Water

    Directory of Open Access Journals (Sweden)

    Allan Pentecost

    2014-12-01

    Full Text Available Cyanobacteria were sampled along two vertical and two horizontal transects in the littoral of Devoke Water, English Lake District. Profiles of cyanobacterium diversity and abundance showed that both attained a maximum close to the water line, but declined rapidly 20–40 cm above it. The distribution of individual species with height together with species and site ordinations showed that several taxa occurred in well-defined zones. A narrow “black zone” in the supralittoral was colonised mainly by species of Calothrix, Dichothrix and Gloeocapsa with pigmented sheaths. There was no evidence of lateral variation of species around the lake, but the height of the black zone correlated positively with wind exposure. The flora of Devoke Water is that of a base-poor mountain lake with some elements of a lowland, more alkaline water-body.

  6. Effects of municipal sewage on the sessile and planctonic bacterial flora of bodies of surface water

    International Nuclear Information System (INIS)

    Lorch, H.J.; Ottow, J.C.G.

    1992-01-01

    For the evaluation of the useability of bacteria as biological indicators of the water state, sections of a flowing body of water (Erms, Schwaebische Alb) with different pollutant levels were investigated between August '82 and July '85. In flowing waves (current biological indicators), the population densities of saprophytes, coliform buds and sporophytes were determined as well as the total number of bacteria number and the morphology of the bacteria. The upgrowth on artificial (glass) and natural (water plants) substrates (integrating biological indicators) was examined with the aid of light microscope and scanning electron microscope in order to measure the long-term influence of different nutrient conditions on the microflora. (orig.) [de

  7. Sensorimotor body-environment interaction serves to regulate emotional experience and exploratory behavior

    Directory of Open Access Journals (Sweden)

    Martin Dobricki

    2016-10-01

    Full Text Available Almost all living species regularly explore environments that they experience as pleasant, aversive, arousing or frightening. We postulate that such exploratory behavior and emotional experience both are regulated based on the interdependent perception of one’s body and stimuli that collectively define a spatial context such as a cliff. Here we examined this by testing if the interaction of the sensory input on one’s gait and the sensory input on the spatial context is modulating both the emotional experience of the environment and its exploration through head motion. To this end, we asked healthy humans to explore a life-sized Virtual Reality simulation of a forest glade by physically walking around in this environment on two narrow rectangular platforms connected by a plank. The platforms and the plank were presented such that they were either placed on ground or on the top of two high bridge piers. Hence, the forest glade was presented either as a “ground” or as a “height” context. Within these two spatial contexts the virtual plank was projected either on the rigid physical floor or onto a bouncy physical plank. Accordingly, the gait of our participants while they crossed the virtual plank was either “smooth” or “bouncy.” We found that in the height context bouncy gait compared to smooth gait increased the orientation of the head below the horizon and intensified the experience of the environment as negative. Whereas, within the ground context bouncy gait increased the orientation of the head towards and above the horizon and made that the environment was experienced as positive. Our findings suggest that the brain of healthy humans is using the interaction of the sensory input on their gait and the sensory input on the spatial context to regulate both the emotional experience of the environment and its exploration through head motion. Keywords: Neuroscience, Psychology

  8. Local Commune Administration as a Regulator of the Local Water Supply and Sewage Disposal Services Market

    OpenAIRE

    Małysko, Jacek

    2012-01-01

    In this article the author discusses problems related to the regulation of water and sewage disposal services market. In the beginning he describes the processes of water supply and sewage disposal taken by the local commune administration as a natural monopoly. Next he characterizes the structure of this market in Poland. Then he presents the role of local commune administration as a regulator. The author concludes by evaluating the existing Polish system of regulating wate...

  9. The Historical Distribution of Main Malaria Foci in Spain as Related to Water Bodies

    Directory of Open Access Journals (Sweden)

    Arturo Sousa

    2014-08-01

    Full Text Available The possible connectivity between the spatial distribution of water bodies suitable for vectors of malaria and endemic malaria foci in Southern Europe is still not well known. Spain was one of the last countries in Western Europe to be declared free of malaria by the World Health Organization (WHO in 1964. This study combines, by means of a spatial-temporal analysis, the historical data of patients and deceased with the distribution of water bodies where the disease-transmitting mosquitos proliferate. Therefore, data from historical archives with a Geographic Information System (GIS, using the Inverse Distance Weighted (IDW interpolation method, was analyzed with the aim of identifying regional differences in the distribution of malaria in Spain. The reasons, why the risk of transmission is concentrated in specific regions, are related to worse socioeconomic conditions (Extremadura, the presence of another vector (Anopheles labranchiae besides A. atroparvus (Levante or large areas of water bodies in conditions to reproduce theses vectors (La Mancha and Western Andalusia. In the particular case of Western Andalusia, in 1913, the relatively high percentage of 4.73% of the surface, equal to 202362 ha, corresponds to wetlands and other unhealthy water bodies. These wetlands have been reduced as a result of desiccation policies and climate change such as the Little Ice Age and Global Climate Change. The comprehension of the main factors of these wetland changes in the past can help us interpret accurately the future risk of malaria re-emergence in temperate latitudes, since it reveals the crucial role of unhealthy water bodies on the distribution, endemicity and eradication of malaria in southern Europe.

  10. Procedure manual: protocol for regulation of petroleum hydrocarbons in water under the special waste and contaminated sites regulation

    International Nuclear Information System (INIS)

    Evans, P.; Partridge, E.

    2002-05-01

    This document details the regulation governing numerical standards for petroleum hydrocarbons in water under the special waste and contaminated sites regulations of British Columbia. Groundwater containing benzene, toluene, ethylbenzene or xylenes in excess of the leachate standards is exempted from the regulatory regime of the Special Waste Regulation. The document contains a description of the conditions that apply to the management of petroleum hydrocarbons in water at contaminated sites. Some definitions are included, followed by an overview of the regulation. The third section deals with authorization and mandatory conditions, while additional requirements that might apply are enumerated in section four. This protocol directly affects the Environmental Management, and the Environmental Protection Regional Operations organizations. 1 tab

  11. EFFECTS TO MODIFY THE CALORIC CONTENT OF WATER ON BODY WEIGHT, WATER, FOOD AND CALORIES CONSUMPTION IN RATS

    Directory of Open Access Journals (Sweden)

    ALMA GABRIELA MARTÍNEZ

    2006-05-01

    Full Text Available Six albino rats were divided in two experimental groups and one control. The experiment began withfifteen days of free access; subsequently experimental groups maintained available three concentrationsof glucose: high, middle and low. First group received high-middle-low-high-middle-low sequence andsecond group received low-middle-high-low-middle-high sequence during six days. Control group notreceived glucose concentrations. Caloric concentration of food never changed. Results suggest thatmodification of caloric concentration in water affects feeding behavior. Nevertheless, water with glucoseconsumption did not change body weight.

  12. Rrol of Zinc Cystenine in the Regulation of Metallothionnein Induction in whole body gamma irradiation rats

    International Nuclear Information System (INIS)

    Azab, Kh. Sh.; Zaharn, A.M.; Noaman, E.

    2004-01-01

    The antioxidant competence of metallothionein (MT) in cellular injury lunched by free radicals released in view of ionizing radiation has been proposed. The present work was conducted to elucidate the role of Zinc cysteine in the regulation of metallothionein induction in whole body gamma irradiated rats. cysteine was delivered to rats via intraperitoneal (i.p) injection at a concentration of 25-mg/kg body weight/day for two successive 2 days. The second injection was 30- min. pre irradiation. Whole body γ- irradiation at dose level 6.5 Gy induced significant increase in the levels of metallothionein in all investigated tissues (serum, liver and kidney) accompanied with significant increase in the levels of Zn in the liver. Cu concentrations increased in serum and kidney and decreased significantly in liver tissues. Data of lipid peroxidation demonstrated significant increase in TBARS as compared with control valuws in serum, liver and kidney. Iron was decreased significantly in serum and liver but a significant increase was recorded in kidney at 7 days after irradiation. Ca increased significantly in the liver only as compared with control rats. In addition, K concentration increased significantly in serum, liver and kidney while, P increased in serum and liver when compared with control values. The administration of zinc cysteine pre-irradiation induces significant increases in liver metallothionin from irradiated rat's value. It is only serum show significant decrease in level of MT from the irradiated rat's value on the 1st day post irradiation. However, the changes observed in the levels of Zn, Cu, Iron and Ca, K and P are less manifested when compared with values of irradiated animals. The reduction in the levels of TBARS was obvious comparing with irradiated rat's data. The amelioration occurred in the levels of Zn, Cu, Fe, Ca, P and K when, zinc cysteine administrated before irradiation postulate the positive role zinc cysteine in the adjustment of

  13. Environmental monitoring and assessment of the water bodies of a pre-construction urban wetland.

    Science.gov (United States)

    Zuo, Shengpeng; Wan, Kun; Zhou, Shoubiao; Ye, Liangtao; Ma, Sumin

    2014-11-01

    It is planned that the Dayanghan Wetland in China will be transformed into a national park but little is known about its current water quality and pollution status. Thus, we monitored the physical and chemical characteristics of the Dayanghan Wetland, which showed that the water quality was generally good. However, the chemical oxygen demand was more than double the reference value, which may be attributable to previous tillage for vegetable crops and other farmlands. In addition, nickel and chromium caused low-level pollution in the water bodies of the Dayanghan Wetland. The mean trophic level index and nutrient quality index were 39.1 and 2.69, respectively. Both indices suggest that the water bodies of the Dayanghan Wetland are in a mesotrophic state and that no eutrophication has occurred. The study would provide a precise report on the status of environmental quality of the water bodies of a typical pre-construction wetland for the administration and decision of the local government and the planning agent.

  14. The influence of the community of water macrophytes on regulation ...

    African Journals Online (AJOL)

    Natural waterplant communities may help prevent the introduction of pollutants. We explore the role of macrophytes in ameliorating the waters of the Kuibyshev reservoir littoral zones through investigating plant and zooplankton communities. We suggest that water vegetation can play a sanative role to improve water quality ...

  15. Contaminant transport modelling in tidal influenced water body for low level liquid waste discharge out

    International Nuclear Information System (INIS)

    Singh, Sanjay; Naidu, Velamala Simhadri

    2018-01-01

    Low level liquid waste is generated from nuclear reactor operation and reprocessing of spent fuel. This waste is discharged into the water body after removing bulk of its radioactivity. Dispersion of contaminant mainly depends on location of outfall and hydrodynamics of water body. For radiological impact assessment, in most of the analytical formulations, source term is taken as continuous release. However, this may not be always true as the water level is influenced by tidal movement and the selected outfall may come under intertidal zone in due course of the tidal cycle. To understand these phenomena, a case study has been carried out to evaluate hydrodynamic characteristics and dilution potential of outfall located in inter-tidal zone using numerical modelling

  16. Microbial processes in the Kanda Bay, a meromictic water body artifically separated from the White Sea.

    Science.gov (United States)

    Savvichev, A S; Demidenko, N A; Krasnova, E D; Kalmatskaya, O V; Kharcheva, A N; Ivanov, M V

    2017-05-01

    Sings of meromixis are found by means of microbiological and biogeochemical investigations in the southernn part of the Kanda Bay, an artificial water body separated front the White Sea with a railway dam. The concentration of oxygen in the bottom layer attained 1.9 mmol/L, intensity of the process of microbial sulfate reduction, 3.0 μmol of sulfur/(L day). The concentration of dissolved methane, 3.7 μmol/L. Isotopic composition of carbon in methane (δ 13 C (CH 4 ) =-79.2‰) indicates to its microbial genesis. At present, Kanda Bay is a sole in Russia man-made marine water body for which there are data on the rate of microbial processes responsible for formation of bottom water layer containing hydrogen sulfide and methane.

  17. [Drinking water regulations in Ukraine and infectious morbidity rate with water pathway of transmission of causative agents].

    Science.gov (United States)

    Surmasheva, E V; Korchak, G I; Mikhienkova, A I; Nikonova, N A; Rosada, M A

    2013-01-01

    These are presented drinking water regulations in Ukraine on microbiological indices in the new state document "Hygienic Drinking water regulations intended for human consumption" (State sanitary regulations and standards (GsanPiN) 2.2.4-171-10). There is reported an analysis of both the open waterbodies water quality and water for centralized water supply in 2007-2011 and 1992-1996 also on sanitary-bacteriological indices for performance of comparative retrospective analysis. There has been shown water quality degradation for open waterbodies, the main sources of water supply for population. Against this background, a marked improvement of drinking water quality has been noted, the number of non-standard samples decreased to 3.6 % compared with 8.8% in the preceding 15 years. This index correlates with a decrease in the number of outbreaks of infections transmitted by water. There was noted unsatisfactory registration of viral infections with water pathway of transmission and the increase in morbidity rate of gastroenterocolitides of unknown etiology that may include acute viral intestinal infections. Expediency to keep "fermentation of glucose" test in bacteriological examination of water in the identification scheme of general coliforms has been substantiated.

  18. Cotton photosynthetic regulation through nutrient and water availability

    Science.gov (United States)

    Photosynthesis is an extremely complicated process that is fundamental to supporting plant growth. It is regulated by multiple internal and external factors. Three factors regulating photosynthesis over which cotton producers can exert some influence are the levels of nitrogen, potassium, and soil...

  19. The lower body muscle activation of intermediate to experienced kayakers when navigating white water.

    Science.gov (United States)

    Murtagh, Misha; Brooks, Darrell; Sinclair, Jonathan; Atkins, Stephen

    2016-11-01

    In white-water kayaking, the legs play a vital part in turning, stabilising and bracing actions. To date, there has been no reported information on neuromuscular activation of the legs in an authentic white-water environment. The aim of the current study was to identify lower body muscle activation, using 'in-boat' electromyography (EMG), whilst navigating a white-water run. Ten experienced male kayakers (age 31.5 ± 12.5 yr, intermediate to advanced experience) completed three successful runs of an international standard white-water course (grade 3 rapids), targeting right and left sides of the course, in a zigzag formation. Surface EMG (sEMG) outputs were generated, bilaterally, for the rectus femoris (RF), vastus lateralis, biceps femoris and gastrocnemius, expressed as a percentage of a dynamic maximal voluntary contraction (dMVC). Only RF showed significantly higher activation than any muscle on the left side of the body, and only on the left side of the course (P = .004; ETA(2) = 0.56). Other results showed no significant difference between muscle activation in the right and left legs during each run, nor when assessed at either the right or left side of the course (P > .05). These findings indicate that contralateral symmetry in lower limb muscle activation is evident during white-water kayaking. This symmetry may provide a stable base to allow more asymmetrical upper body and trunk movements to be fully optimised. Lower body symmetry development should be considered useful in targeted training programmes for white-water kayakers.

  20. DISCO Interacting Protein 2 regulates axonal bifurcation and guidance of Drosophila mushroom body neurons.

    Science.gov (United States)

    Nitta, Yohei; Yamazaki, Daisuke; Sugie, Atsushi; Hiroi, Makoto; Tabata, Tetsuya

    2017-01-15

    Axonal branching is one of the key processes within the enormous complexity of the nervous system to enable a single neuron to send information to multiple targets. However, the molecular mechanisms that control branch formation are poorly understood. In particular, previous studies have rarely addressed the mechanisms underlying axonal bifurcation, in which axons form new branches via splitting of the growth cone. We demonstrate that DISCO Interacting Protein 2 (DIP2) is required for precise axonal bifurcation in Drosophila mushroom body (MB) neurons by suppressing ectopic bifurcation and regulating the guidance of sister axons. We also found that DIP2 localize to the plasma membrane. Domain function analysis revealed that the AMP-synthetase domains of DIP2 are essential for its function, which may involve exerting a catalytic activity that modifies fatty acids. Genetic analysis and subsequent biochemical analysis suggested that DIP2 is involved in the fatty acid metabolization of acyl-CoA. Taken together, our results reveal a function of DIP2 in the developing nervous system and provide a potential functional relationship between fatty acid metabolism and axon morphogenesis. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Body composition impacts appetite regulation in middle childhood. A prospective study of Norwegian community children.

    Science.gov (United States)

    Steinsbekk, Silje; Llewellyn, Clare H; Fildes, Alison; Wichstrøm, Lars

    2017-05-30

    Research suggests a role for both fat mass and muscle mass in appetite regulation, but the longitudinal relationships between them have not yet been examined in children. The present study therefore aimed to explore the prospective relationships between fat mass, muscle mass and the appetitive traits food responsiveness and satiety responsiveness in middle childhood. Food responsiveness and satiety responsiveness were measured using the parent-reported Children's Eating Behavior Questionnaire in a representative sample of Norwegian 6 year olds, followed up at 8 and 10 years of age (n = 807). Body composition was measured by bioelectrical impedance. Applying a structural equation modeling framework we found that higher fat mass predicted greater increases in food responsiveness over time, whereas greater muscle mass predicted decreases in satiety responsiveness. This pattern was consistent both from ages 6 to 8 and from ages 8 to 10 years. Our study is the first to reveal that fat mass and muscle mass predict distinct changes in different appetitive traits over time. Replication of findings in non-European populations are needed, as are studies of children in other age groups. Future studies should also aim to reveal the underlying mechanisms.

  2. Not Good, but Not All Bad: Dehydration Effects on Body Fluids, Organ Masses, and Water Flux through the Skin of Rhinella schneideri (Amphibia, Bufonidae).

    Science.gov (United States)

    Anderson, Rodolfo C O; Bovo, Rafael P; Eismann, Carlos E; Menegario, Amauri A; Andrade, Denis V

    Because of their permeable skin, terrestrial amphibians are constantly challenged by the potential risk of dehydration. However, some of the physiological consequences associated with dehydration may affect aspects that are themselves relevant to the regulation of water balance. Accordingly, we examined the effects of graded levels of dehydration on the rates of evaporative water loss and water absorption through the skin in the terrestrial Neotropical toad, Rhinella schneideri. Concomitantly, we monitored the effects of dehydration on the mass of visceral organs; hematocrit and hemoglobin content; plasma osmolality; and plasma concentration of urea, sodium, chloride, and potassium. We found that dehydration caused an increase in the concentration of body fluids, as indicated by virtually all the parameters examined. There was a proportional change in the relative masses of visceral organs, except for the liver and kidneys, which exhibited a decrease in their relative masses greater than the whole-body level of dehydration. Changes-or the preservation-of relative organ masses during dehydration may be explained by organ-specific physiological adjustments in response to the functional stress introduced by the dehydration itself. As dehydration progressed, evaporative water loss diminished and water reabsorption increased. In both cases, the increase in body fluid concentration associated with the dehydration provided the osmotic driver for these changes in water flux. Additionally, dehydration-induced alterations on the cutaneous barrier may also have contributed to the decrease in water flux. Dehydration, therefore, while posing a considerable challenge on the water balance regulation of anurans, paradoxically facilitates water conservation and absorption.

  3. A global, 30-m resolution land-surface water body dataset for 2000

    Science.gov (United States)

    Feng, M.; Sexton, J. O.; Huang, C.; Song, D. X.; Song, X. P.; Channan, S.; Townshend, J. R.

    2014-12-01

    Inland surface water is essential to terrestrial ecosystems and human civilization. The distribution of surface water in space and its change over time are related to many agricultural, environmental and ecological issues, and are important factors that must be considered in human socioeconomic development. Accurate mapping of surface water is essential for both scientific research and policy-driven applications. Satellite-based remote sensing provides snapshots of Earth's surface and can be used as the main input for water mapping, especially in large areas. Global water areas have been mapped with coarse resolution remotely sensed data (e.g., the Moderate Resolution Imaging Spectroradiometer (MODIS)). However, most inland rivers and water bodies, as well as their changes, are too small to map at such coarse resolutions. Landsat TM (Thematic Mapper) and ETM+ (Enhanced Thematic Mapper Plus) imagery has a 30m spatial resolution and provides decades of records (~40 years). Since 2008, the opening of the Landsat archive, coupled with relatively lower costs associated with computing and data storage, has made comprehensive study of the dynamic changes of surface water over large even global areas more feasible. Although Landsat images have been used for regional and even global water mapping, the method can hardly be automated due to the difficulties on distinguishing inland surface water with variant degrees of impurities and mixing of soil background with only Landsat data. The spectral similarities to other land cover types, e.g., shadow and glacier remnants, also cause misidentification. We have developed a probabilistic based automatic approach for mapping inland surface water bodies. Landsat surface reflectance in multiple bands, derived water indices, and data from other sources are integrated to maximize the ability of identifying water without human interference. The approach has been implemented with open-source libraries to facilitate processing large

  4. Fluctuating water depths affect American alligator (Alligator mississippiensis) body condition in the Everglades, Florida, USA

    Science.gov (United States)

    Brandt, Laura A.; Beauchamp, Jeffrey S.; Jeffery, Brian M.; Cherkiss, Michael S.; Mazzotti, Frank J.

    2016-01-01

    Successful restoration of wetland ecosystems requires knowledge of wetland hydrologic patterns and an understanding of how those patterns affect wetland plant and animal populations.Within the Everglades, Florida, USA restoration, an applied science strategy including conceptual ecological models linking drivers to indicators is being used to organize current scientific understanding to support restoration efforts. A key driver of the ecosystem affecting the distribution and abundance of organisms is the timing, distribution, and volume of water flows that result in water depth patterns across the landscape. American alligators (Alligator mississippiensis) are one of the ecological indicators being used to assess Everglades restoration because they are a keystone species and integrate biological impacts of hydrological operations through all life stages. Alligator body condition (the relative fatness of an animal) is one of the metrics being used and targets have been set to allow us to track progress. We examined trends in alligator body condition using Fulton’s K over a 15 year period (2000–2014) at seven different wetland areas within the Everglades ecosystem, assessed patterns and trends relative to restoration targets, and related those trends to hydrologic variables. We developed a series of 17 a priori hypotheses that we tested with an information theoretic approach to identify which hydrologic factors affect alligator body condition. Alligator body condition was highest throughout the Everglades during the early 2000s and is approximately 5–10% lower now (2014). Values have varied by year, area, and hydrology. Body condition was positively correlated with range in water depth and fall water depth. Our top model was the “Current” model and included variables that describe current year hydrology (spring depth, fall depth, hydroperiod, range, interaction of range and fall depth, interaction of range and hydroperiod). Across all models, interaction

  5. Body characteristics, [corrected] dietary protein and body weight regulation. Reconciling conflicting results from intervention and observational studies?

    Directory of Open Access Journals (Sweden)

    Mikkel Z Ankarfeldt

    Full Text Available Physiological evidence indicates that high-protein diets reduce caloric intake and increase thermogenic response, which may prevent weight gain and regain after weight loss. Clinical trials have shown such effects, whereas observational cohort studies suggest an association between greater protein intake and weight gain. In both types of studies the results are based on average weight changes, and show considerable diversity in both directions. This study investigates whether the discrepancy in the evidence could be due to recruitment of overweight and obese individuals into clinical trials.Data were available from the European Diet, Obesity and Genes (DiOGenes post-weight-loss weight-maintenance trial and the Danish Diet, Cancer and Health (DCH cohort. Participants of the DCH cohort were matched with participants from the DiOGenes trial on gender, diet, and body characteristics. Different subsets of the DCH-participants, comparable with the trial participants, were analyzed for weight maintenance according to the randomization status (high or low protein of the matched trial participants.Trial participants were generally heavier, had larger waist circumference and larger fat mass than the participants in the entire DCH cohort. A better weight maintenance in the high-protein group compared to the low protein group was observed in the subgroups of the DCH cohort matching body characteristics of the trial participants.This modified observational study, minimized the differences between the RCT and observational data with regard to dietary intake, participant characteristics and statistical analysis. Compared with low protein diet the high protein diet was associated with better weight maintenance when individuals with greater body mass index and waist circumference were analyzed. Selecting subsets of large-scale observational cohort studies with similar characteristics as participants in clinical trials may reconcile the otherwise conflicting

  6. Effect of Aggression Regulation on Eating Disorder Pathology : RCT of a Brief Body and Movement Oriented Intervention

    NARCIS (Netherlands)

    Boerhout, Cees; Swart, Marte; Van Busschbach, Jooske T.; Hoek, Hans W.

    ObjectiveThe objective of the study is to evaluate the effect of a brief body and movement oriented intervention on aggression regulation and eating disorder pathology for individuals with eating disorders. MethodIn a first randomized controlled trial, 40 women were allocated to either the

  7. Detection of Water Bodies from AVHRR Data—A TIMELINE Thematic Processor

    Directory of Open Access Journals (Sweden)

    Andreas J. Dietz

    2017-01-01

    Full Text Available The assessment of water body dynamics is not only in itself a topic of strong demand, but the presence of water bodies is important information when it comes to the derivation of products such as land surface temperature, leaf area index, or snow/ice cover mapping from satellite data. For the TIMELINE project, which aims to derive such products for a long time series of Advanced Very High Resolution Radiometer (AVHRR data for Europe, precise water masks are therefore not only an important stand-alone product themselves, they are also an essential interstage information layer, which has to be produced automatically after preprocessing of the raw satellite data. The respective orbit segments from AVHRR are usually more than 2000 km wide and several thousand km long, thus leading to fundamentally different observation geometries, including varying sea surface temperatures, wave patterns, and sediment and algae loads. The water detection algorithm has to be able to manage these conditions based on a limited amount of spectral channels and bandwidths. After reviewing and testing already available methods for water body detection, we concluded that they cannot fully overcome the existing challenges and limitations. Therefore an extended approach was implemented, which takes into account the variations of the reflectance properties of water surfaces on a local to regional scale; the dynamic local threshold determination will train itself automatically by extracting a coarse-scale classification threshold, which is refined successively while analyzing subsets of the orbit segment. The threshold is then interpolated by fitting a minimum curvature surface before additional steps also relying on the brightness temperature are included to reduce possible misclassifications. The classification results have been validated using Landsat and Moderate Resolution Imaging Spectroradiometer (MODIS data and proven an overall accuracy of 93.4%, with the majority of

  8. Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man.

    Science.gov (United States)

    Hallschmid, Manfred; Benedict, Christian; Born, Jan; Fehm, Horst-Lorenz; Kern, Werner

    2004-10-30

    Maintaining a stable body weight set-point is assumed to rely on a homeostatic central nervous system (CNS) regulation of body fat with the particular involvement of hypothalamic pathways. The peripheral adiposity signals insulin and leptin convey information on the amount of energy stored as body fat to the arcuate nucleus of the hypothalamus, where anabolic/orexigenic and catabolic/anorexigenic pathways interact to regulate food intake and energy expenditure. One of the most prominent orexigenic messengers is neuropeptide Y (NPY), whereas melanocortins, including alpha-melanocyte-stimulating hormone (alpha-MSH), are essential for inducing anorexigenic effects. The melanocortin receptor 4 (MC4-R) plays the most important role in mediating catabolic effects of alpha-MSH. In this review, we present a series of own studies on NPY, insulin and MSH/ACTH4-10, an MC4-R agonist. The studies were all based on the intranasal route of administration which enables a direct access of the peptides to hypothalamic functions. NPY acutely attenuated electrocortical signs of meal-related satiety. Prolonged intranasal administration of insulin as well as of MSH induced weight loss in healthy human subjects. However, overweight subjects did not lose body fat after MSH administration. The results corroborate in humans the significance of all three messengers for the central nervous regulation of adiposity and might contribute to the future development of medical strategies against body-weight-related disorders.

  9. The daily radon dose in body organs caused by drinking milk and water

    International Nuclear Information System (INIS)

    Mansoureh Mansour Bahmani; Mohammad Reza Rezaie; Elham Rezvan Nejad; Hassan Reza Dehghan

    2014-01-01

    Milk is considered as the richest nutrition, being used by people. When drinking milk or water the radon gas will transfer from air to them rapidly. Since milk is majorly composed of water, probably radon existence in livestock consumable water could be the main cause of its presence in milk. Different portion of milk changed by radon gamma ray and consumption of radon included water or milk has its effects on the human body. For investigation the effect of radon in water or milk on human organs, this study has been done in two phases with MCNPX software. In the first phase, the dose rate of absorbed gamma ray by different portion of milk which is indoctrinated by 1 Bq/m 3 of radon during a day is calculated. Moreover, the effects shown by milk and its components in radon gamma spectrum, which is demonstrator of milk absorption spectrum, are also surveyed. In the second phase as well, according to the human body phantom, the absorbed gamma dose caused by daily consumption of indoctrinated water or milk with 1 Bq/m 3 radon is calculated. The production rate of free radicals in milk and its different components are derived according to escape data of MCNPX code. (author)

  10. CHARACTERIZATION OF SALMONELLA SPECIES FROM WATER BODIES IN DAR-ES-SALAAM CITY, TANZANIA

    Directory of Open Access Journals (Sweden)

    Eliningaya Kweka

    2013-03-01

    Full Text Available Background: Water-borne diseases are the most common cause of illness and death among the poor population from developing countries. The majority of the people are inadequately aware that aquatic environment is a major source of salmonellosis. Dar es Salaam city is among the cities with most of its population live in squatter. Typhoid fever ranks second with 14.3% of all notifiable disease cases in the city. The city experience water scarcity which forces water wells and rivers to become the main sources of water for domestic use and livestock. This study therefore, characterized Salmonella strains from different water bodies of city as possible sources for enteric diseases endemicity. Methods: The Salmonella Chromogenic Agar (SC Agar and Kligler Iron Agar (KIA media were used for isolation and enumeration of the strains. The inoculated cultures were incubated at 370C for 24 hours. Salmonella colonies were confirmed by magenta colorations and hydrogen sulfide production on SC Agar and KIA Agar, respectively. The Analytical Profile Index 20 Enterobacteriaceae kit (API 20E kit was used to identify Salmonella species. Results: Based on the API 20E kit, the identified Salmonella species from different water bodies were Salmonella ser. paratyphi A (96.9%, Salmonella cholelaesuis spp choleraesuis (99.5% and Salmonella typhi (99.9%. Conclusion: This study shows that shallow wells and rivers which are mainly used by the city dwellers were highly contaminated with Salmonella and were more contaminated than deep wells and marine water bodies. This warrants further investigation on the disease mapping in the urban and peri-urban areas.

  11. Characterization of Salmonella species from water bodies in Dar-Es-Salaam city, Tanzania

    Directory of Open Access Journals (Sweden)

    Eliningaya Kweka

    2013-01-01

    Full Text Available Background: Water-borne diseases are the most common cause of illness and death among the poor population from developing countries. The majority of the people are inadequately aware that aquatic environment is a major source of salmonellosis. Dar es Salaam city is among the cities with most of its population live in squatter. Typhoid fever ranks second with 14.3% of all notifiable disease cases in the city. The city experience water scarcity which forces water wells and rivers to become the main sources of water for domestic use and livestock. This study therefore, characterized Salmonella strains from different water bodies of city as possible sources for enteric diseases endemicity. Methods: The Salmonella Chromogenic Agar (SC Agar and Kligler Iron Agar (KIA media were used for isolation and enumeration of the strains. The inoculated cultures were incubated at 370C for 24 hours. Salmonella colonies were confirmed by magenta colorations and hydrogen sulfide production on SC Agar and KIA Agar, respectively. The Analytical Profile Index 20 Enterobacteriaceae kit (API 20E kit was used to identify Salmonella species. Results: Based on the API 20E kit, the  identified Salmonella species from different water bodies were Salmonella ser. paratyphi A (96.9%, Salmonella cholelaesuis spp choleraesuis (99.5% and Salmonella typhi (99.9%. Conclusion: This study shows that shallow wells and rivers which are mainly used by the city dwellers were highly contaminated with Salmonella and were more contaminated than deep wells and marine water bodies. This warrants further investigation on the disease mapping in the urban and peri-urban areas.

  12. Bioimpedance index for measurement of total body water in severely malnourished children

    DEFF Research Database (Denmark)

    Girma, Tsinuel; Kæstel, Pernille; Workeneh, Netsanet

    2016-01-01

    BACKGROUND & OBJECTIVES: Restoration of body composition indicates successful management of severe acute malnutrition (SAM). Bioimpedance (BI) index (height(2)/resistance) is used to predict total body water (TBW) but its performance in SAM, especially with oedema, requires further investigation....... SUBJECTS/METHODS: Children with SAM (mid-arm circumference ...Hzs. Pre- and post-deuterium dose saliva samples were analysed using isotope-ratio mass spectrometry. TBW was regressed on H(2)/Z. Xc and R were height (H)-indexed, and Xc/H plotted against R/H. RESULTS: Thirty five children (16 non-oedematous and 19 oedematous) with median (interquartile range) age of 42...

  13. Regulation of body fluid and salt homeostasis--from observations in space to new concepts on Earth.

    Science.gov (United States)

    Gerzer, R; Heer, M

    2005-08-01

    The present manuscript summarizes recent discoveries that were made by studying salt and fluid homeostasis in weightlessness. These data indicate that 1. atrial natriuretic peptide appears not to play an important role in natriuresis in physiology, 2. the distribution of body fluids appears to be tightly coupled with hunger and thirst regulation, 3. intrathoracic pressure may be an important co-regulator of body fluid homeostasis, 4. a so far unknown low-affinity, high capacity osmotically inactive sodium storage mechanism appears to be present in humans that is acting through sodium/hydrogen exchange on glycosaminoglycans and might explain the pathophysiology, e.g., of salt sensitive hypertension. The surprising and unexpected data underline that weightlessness is an excellent tool to investigate the physiology of our human body: If we knew it, we should be able to predict changes that occur when gravity is absent. But, as data from space demonstrate, we do not.

  14. The use of biomarkers as integrative tools for transitional water bodies monitoring in the Water Framework Directive context - A holistic approach in Minho river transitional waters.

    Science.gov (United States)

    Capela, R; Raimundo, J; Santos, M M; Caetano, M; Micaelo, C; Vale, C; Guimarães, L; Reis-Henriques, M A

    2016-01-01

    The Water Framework Directive (WFD) provides an important legislative opportunity to promote and implement an integrated approach for the protection of inland surface waters, transitional waters, coastal waters and groundwaters. The transitional waters constitute a central piece as they are usually under high environmental pressure and by their inherent characteristics present monitoring challenges. Integrating water quality monitoring with biological monitoring can increase the cost-effectiveness of monitoring efforts. One way of doing this is with biomarkers, which effectively integrate physical-chemical status and biological quality elements, dealing holistically with adverse consequences on the health of water bodies. The new Marine Strategy Framework Directive (MSFD) already incorporates the biomarker approach. Given the recent activities of OSPAR and HELCOM to harmonize existing monitoring guidelines between MSFD and WFD the use of similar methodologies should be fostered. To illustrate the potential of the biomarker approach, juveniles of flounder (Platichthys flesus) were used to evaluate the quality of the Minho river-estuary water bodies. The use of juveniles instead of adults eliminates several confounding factors such changes on the biological responses associated with reproduction. Here, a panel of well-established biomarkers, EROD, AChE, SOD, CAT, GST, LPO, ENA and FACs (1-Hydroxyrene) were selected and measured along with a gradient of different physical conditions, and integrated with trace elements characterization on both biota and sediments. In general, a clear profile along the water bodies was found, with low seasonal and spatial variation, consistent with a low impacted area. Overall, the results support the use of both the battery of biomarkers and the use of juvenile flounders in the monitoring of the water quality status within the WFD. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies.

    Science.gov (United States)

    Selimkhanov, Jangir; Thompson, W Clayton; Patterson, Terrell A; Hadcock, John R; Scott, Dennis O; Maurer, Tristan S; Musante, Cynthia J

    2016-01-01

    The purpose of this work is to develop a mathematical model of energy balance and body weight regulation that can predict species-specific response to common pre-clinical interventions. To this end, we evaluate the ability of a previously published mathematical model of mouse metabolism to describe changes in body weight and body composition in rats in response to two short-term interventions. First, we adapt the model to describe body weight and composition changes in Sprague-Dawley rats by fitting to data previously collected from a 26-day caloric restriction study. The calibrated model is subsequently used to describe changes in rat body weight and composition in a 23-day cannabinoid receptor 1 antagonist (CB1Ra) study. While the model describes body weight data well, it fails to replicate body composition changes with CB1Ra treatment. Evaluation of a key model assumption about deposition of fat and fat-free masses shows a limitation of the model in short-term studies due to the constraint placed on the relative change in body composition components. We demonstrate that the model can be modified to overcome this limitation, and propose additional measurements to further test the proposed model predictions. These findings illustrate how mathematical models can be used to support drug discovery and development by identifying key knowledge gaps and aiding in the design of additional experiments to further our understanding of disease-relevant and species-specific physiology.

  16. Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies.

    Directory of Open Access Journals (Sweden)

    Jangir Selimkhanov

    Full Text Available The purpose of this work is to develop a mathematical model of energy balance and body weight regulation that can predict species-specific response to common pre-clinical interventions. To this end, we evaluate the ability of a previously published mathematical model of mouse metabolism to describe changes in body weight and body composition in rats in response to two short-term interventions. First, we adapt the model to describe body weight and composition changes in Sprague-Dawley rats by fitting to data previously collected from a 26-day caloric restriction study. The calibrated model is subsequently used to describe changes in rat body weight and composition in a 23-day cannabinoid receptor 1 antagonist (CB1Ra study. While the model describes body weight data well, it fails to replicate body composition changes with CB1Ra treatment. Evaluation of a key model assumption about deposition of fat and fat-free masses shows a limitation of the model in short-term studies due to the constraint placed on the relative change in body composition components. We demonstrate that the model can be modified to overcome this limitation, and propose additional measurements to further test the proposed model predictions. These findings illustrate how mathematical models can be used to support drug discovery and development by identifying key knowledge gaps and aiding in the design of additional experiments to further our understanding of disease-relevant and species-specific physiology.

  17. Monitoring of heavy metals in selected Water Supply Systems in Poland, in relation to current regulations

    Science.gov (United States)

    Szuster-Janiaczyk, Agnieszka; Zeuschner, Piotr; Noga, Paweł; Skrzypczak, Marta

    2018-02-01

    The study presents an analysis of water quality monitoring in terms of the content of heavy metals, which is conducted in three independent water supply systems in Poland. The analysis showed that the monitoring of heavy metals isn't reliable - both the quantity of tested water samples and the location of the monitoring points are the problem. The analysis of changes in water quality from raw water to tap water was possible only for one of the analysed systems and indicate a gradual deterioration of water quality, although still within acceptable limits of legal regulations.

  18. Body mass, energy intake, and water consumption of rats and humans during space flight

    Science.gov (United States)

    Wade, C. E.; Miller, M. M.; Baer, L. A.; Moran, M. M.; Steele, M. K.; Stein, T. P.

    2002-01-01

    Alteration of metabolism has been suggested as a major limiting factor to long-term space flight. In humans and primates, a negative energy balance has been reported. The metabolic response of rats to space flight has been suggested to result in a negative energy balance. We hypothesized that rats flown in space would maintain energy balance as indicated by maintenance of caloric intake and body mass gain. Further, the metabolism of the rat would be similar to that of laboratory-reared animals. We studied the results from 15 space flights lasting 4 to 19 d. There was no difference in average body weight (206 +/- 13.9 versus 206 +/- 14.8 g), body weight gain (5.8 +/- 0.48 versus 5.9 +/- 0.56 g/d), caloric intake (309 +/- 21.0 versus 309 +/- 20.1 kcal/kg of body mass per day), or water intake (200 +/- 8.6 versus 199 +/- 9.3 mL/kg of body mass per day) between flight and ground control animals. Compared with standard laboratory animals of similar body mass, no differences were noted. The observations suggested that the negative balance observed in humans and non-human primates may be due to other factors in the space-flight environment.

  19. Evaluation of nuclear magnetic resonance spectroscopy for determination of deuterium abundance in body fluids: application to measurement of total-body water in human infants

    International Nuclear Information System (INIS)

    Rebouche, C.J.; Pearson, G.A.; Serfass, R.E.; Roth, C.W.; Finley, J.W.

    1987-01-01

    Nuclear magnetic resonance (NMR) spectroscopy was used to quantitate abundance of 2H in body water of human infants. This method provides precise measurement of total-body water without the extensive sample preparation requirements of previously described methods for determination of 2H content in body fluids. 2H2O (1 g/kg body weight) was administered to infants and saliva and urine were collected for up to 5 h. An internal standard was added directly to the fluid specimen and 2H enrichment in water was measured by NMR spectroscopy. Working range of deuterium abundance was 0.04-0.32 atom %. Coefficients of variation for saliva samples at 0.20 atom % 2H was 1.97%. 2H content in urine and saliva water reached a plateau by 4 h after administration, and amounts in the two fluids were virtually identical. Mean total-body water determination for six infants was 58.3 +/- 5.8% of body weight (range 53-66%)

  20. The principles of good regulation in the water sector

    NARCIS (Netherlands)

    Lavrijssen, Saskia; Vitez, Blanka

    2015-01-01

    In March 2014, the OECD issued a report in which it indicated that the Netherlands “has an excellent track record on water management in several areas” The OECD mentions for example that the Netherlands has developed a “strong economy and robust water industry”, this despite that 55% of the

  1. Environmental impacts of Sheba tannery (Ethiopia effluents on the surrounding water bodies

    Directory of Open Access Journals (Sweden)

    Abraha Gebrekidan

    2009-08-01

    Full Text Available The levels of hexavalent chromium from direct and treated Sheba tannery effluents, downstream river and spring water samples and upstream river water samples were determined spectrophotometrically by the s-diphenylcarbazide method at 540 nm. Temporal and representative samples were collected from the untreated tannery effluent (S1, sedimentation pond (S2, chromium oxidation pond (S3, downstream river (S4, downstream spring (S5 and 5 kms upstream river (S6. The mean levels of hexavalent chromium in S1, S2, S3, S4, S5 and S6 were 10.54, 9.15, 7.82, 0.58, 0.54 and 0.015 mg/L, respectively. The levels of hexavalent chromium in the downstream river and spring water samples exceed the World Health Organization (WHO permissible limit of total chromium in drinking waters (0.05 mg/L as opposed to the levels in the upstream waters. The increased concentrations of Cr(VI in the water samples indicate the possible environmental pollution of the downstream water bodies by the Sheba tannery effluents. In view of the toxicity and related environmental hazards, the levels of hexavalent chromium from the Sheba tannery effluents must be reduced to a permissible limit before discharging into the down stream waters being used for domestic purposes by the nearby communities.

  2. When neuroscience gets wet and hardcore: neurocognitive markers obtained during whole body water immersion.

    Science.gov (United States)

    Schneider, Stefan; Cheung, Jeffrey J H; Frick, Hosea; Krehan, Sebastian; Micke, Florian; Sauer, Marc; Dalecki, Marc; Dern, Sebastian

    2014-10-01

    Neutral buoyancy facilities are used to prepare astronauts and cosmonauts for extra vehicular activities e.g. on-board of the International Space Station. While previous studies indicated a decrease in cognitive performance in an under water setting, they have only provided behavioural data. This study aimed to review whether recording of electro cortical activity by the use of electroencephalography (EEG) is possible in an under water setting and if so, to identify the influence of water immersion at a depth of 4 m on neurocognitive markers. Ten male subjects performed a cognitive choice-reaction times (RT) task that progressed through five levels of increasing difficulty on land and when submerged 4 m under water. N200 latency and amplitude in the occipital and frontal areas were measured, and baseline cortical activity was measured during rest in both conditions. Neither RT nor amplitude or latency of the N200 showed any significant changes between the land and the under water conditions. Also theta, alpha and beta frequencies showed no differences between the two conditions. The data provided in this study demonstrate the possibility of recording EEG even under the extreme conditions of full body water immersion. The lack of cognitive impairment in RT and N200 in the under water condition may be explained by the fact that only experienced divers participated in the study. As a proof of principle, this study generates many new experimental possibilities that will improve our understanding of cognitive processes under water.

  3. Regulation of body temperature and nociception induced by non-noxious stress in rat.

    Science.gov (United States)

    Vidal, C; Suaudeau, C; Jacob, J

    1984-04-09

    The effects of 3 different non-noxious stressors on body temperature (Tb) were investigated in the rat: (1) loose restraint in cylinders, (2) removal of the rats from cylinders, exposure to a novel environment and replacement in cylinders, a stressor called here 'novelty', and (3) gentle holding of the rats by the nape of the neck. Loose restraint and 'novelty' produced hyperthermia. On the contrary, holding induced hypothermia. Hypophysectomy (HX) reduced basal Tb, abolished restraint hyperthermia and reduced both 'novelty' hyperthermia and holding hypothermia. Dexamethasone ( DEXA ) had no effect upon either restraint or novelty hyperthermia but reduced the hypothermia. Naloxone (Nx) produced a slight fall in basal Tb accounting for its reduction of restraint and 'novelty' hyperthermias ; it did not affect holding hypothermia. The inhibitory effects of HX suggest a participation of the pituitary in the hyperthermias ; the neurointermediate lobe would be involved as the hyperthermias were not affected by DEXA , which is known to block the stress-induced release of pituitary secretions from the anterior lobe but not from the neurointermediate lobe. In contrast, substances from the anterior lobe might participate in hypothermia due to holding since it is reduced by HX and DEXA . As to the effects of Nx, endogenous opioids would not be significantly involved in the thermic effects of the stressors used in this study; they might play, if any, only a minor role in the regulation of basal Tb. These results are compared with those previously obtained on nociception using the same non-noxious stressors. It emerges that, depending on the stressor, different types of association between thermoregulation and nociception may occur, i.e. hyperthermia with analgesia, hyperthermia with hyperalgesia and hypothermia with hyperalgesia.

  4. Flume experiments on wind induced flow in static water bodies in the presence of protruding vegetation

    Science.gov (United States)

    Banerjee, Tirtha; Muste, Marian; Katul, Gabriel

    2015-02-01

    The problem of wind-induced flow in inland waters is drawing significant research attention given its relevance to a plethora of applications in wetlands including treatment designs, pollution reduction, and biogeochemical cycling. The present work addresses the role of wind induced turbulence and waves within an otherwise static water body in the presence of rigid and flexible emergent vegetation through flume experimentation and time series analysis. Because no prior example of Particle Imaging Velocimetry (PIV) experiments involving air-water and flexible oscillating components have been found in the literature, a spectral analysis framework is needed and proposed here to guide the analysis involving noise, wave and turbulence separation. The experiments reveal that wave and turbulence effects are simultaneously produced at the air-water interface and the nature of their coexistence is found to vary with different flow parameters including water level, mean wind speed, vegetation density and its flexibility. For deep water levels, signature of fine-scaled inertial turbulence is found at deeper layers of the water system. The wave action appears stronger close to the air-water interface and damped by the turbulence deeper inside the water system. As expected, wave action is found to be dominated in a certain frequency range driven by the wind forcing, while it is also diffused to lower frequencies by means of (wind-induced) oscillations in vegetation. Regarding the mean water velocity, existence of a counter-current flow and its switching to fully forward flow in the direction of the wind under certain combinations of flow parameters were studied. The relative importance of wave and turbulence to the overall energy, degree of anisotropy in the turbulent energy components, and turbulent momentum transport at different depths from the air-water interface and flow combinations were then quantified. The flume experiments reported here differ from previous laboratory

  5. Case study on rehabilitation of a polluted urban water body in Yangtze River Basin.

    Science.gov (United States)

    Wu, Juan; Cheng, Shuiping; Li, Zhu; Guo, Weijie; Zhong, Fei; Yin, Daqiang

    2013-10-01

    In the past three decades, the fast development of economy and urbanization has caused increasingly severe pollutions of urban water bodies in China. Consequently, eutrophication and deterioration of aquatic ecosystem, which is especially significant for aquatic vegetation, inevitably became a pervasive problem across the Yangtze River Basin. To rehabilitate the degraded urban water bodies, vegetation replanting is an important issue to improve water quality and to rehabilitate ecosystem. As a case study, a representative polluted urban river, Nanfeihe River, in Hefei City, Anhui Province, was chosen to be a rehabilitation target. In October 2009 and May 2010, 13 species of indigenous and prevalent macrophytes, including seven species emergent, one species floating leaved, and five species submersed macrophytes, were planted along the bank slopes and in the river. Through 1.5 years' replanting practice, the water quality and biodiversity of the river had been improved. The concentrations of total nitrogen (TN), total phosphorus (TP), and ammonia nitrogen (NH4 (+)-N) declined by 46.0, 39.5, and 60.4 %, respectively. The species of macrophytes increased from 14 to 60, and the biodiversity of phytoplankton rose significantly in the river (purban waters restoration in the middle-downstream area of Yangtze River Base.

  6. Revitalization model of tapioca industry through environmental awareness reinforcement for minimizing water body contamination

    Science.gov (United States)

    Banowati, E.; Indriyanti, D. R.; Juhadi

    2018-03-01

    Tapioca industry in Margoyoso District is a household industry which positively contributes to the growth of the region's economy as it is able to absorb 6,61% of productive age populationor absorb 3,300 workers.On the other hand, the industry impacts contamination of river water in the form of pollutants dissolved materials and particulates into water bodies so that the quality of water decreases even does not work anymore in accordance with the allocation for irrigation or run off of agriculture. The purpose of this research is to: strengthen environmental awareness; calculate the success of the reinforcement action and minimize water body contamination. The research was conducted in two villages of tapioca industry center in Margoyoso district - Pati Regency Administration Area. The determination coefficient of R Square is 0.802 which indicates a successful effort of 80.2%. Regression equation Y = 34.097 + 0.608 X. Industrial entrepreneur's concern increased on 8.45 from total indicator or position to 70.72 so that the gradual effort showed success to minimize water contamination of Suwatu River. The business community of tapioca should build installation of wastewater treatment.

  7. Low species richness of non-biting midges (Diptera: Chironomidae) in Neotropical artificial urban water bodies

    DEFF Research Database (Denmark)

    Hamerlik, Ladislav; Jacobsen, Dean; Brodersen, Klaus Peter

    2011-01-01

    Chironomid assemblages of 22 artificial water bodies, mainly fountains, in two South American cities were surveyed. We found surprisingly low diversities, with a total of 11 taxa, averaging two taxa per site. The typical fountain assemblages mainly consisted of common species that have a wide...... distribution pattern and are tolerant to organic pollution. Also taxa independent of the natural aquatic sources, such as tap-water and semi-terrestrial species were represented. There was no significant difference between the taxa richness of the two S. American regions, however, the assemblage structures...

  8. Studies on the physico-chemical parameters of Omi water body of ...

    African Journals Online (AJOL)

    In Omi water body, the physico-chemical parameters such as dissolved oxygen ranged from 1.4 to 4.8 mg/L; pH, 6.7 to 7.2; temperature, 26.5 to 31.5°C; alkalinity, 24.2 to 25.4 ppm; conductivity, 23.0 to 28.3 Ohms/cm; turbidity 0.11 to 0.15 m; and free carbon dioxide from 3.5 to 4.5 mg/L. Dissolved oxygen, pH and water ...

  9. A Novel Approach to Extract Water Body from ASAR Dual-Polarized Data

    International Nuclear Information System (INIS)

    Ma, Jianwei; Song, Xiaoning; Leng, Pei; Zhou, Fangcheng; Li, Shuang; Li, Xiaotao

    2014-01-01

    SAR (Synthetic Aperture Radar) has become a useful and efficient method for monitoring flood extent due to its capability of 24-hour and all weather observation. In this paper, a novel approach is proposed to extract water bodies from ASAR dual-polarized images. Firstly, a new SAR image was created from ASAR Dual-Polarized data using a discrete wavelet transformation (DWT) fusion method. Then, a modified Otsu threshold method was used to extract water bodies of Poyang Lake with the new fused image. Next, this image was compared with the one extracted from ETM+ data. The result showed that the fused image was feasible and more accurate. Besides, it could reduce the influences of shadow and noise. Moreover, the approach could be conducted automatically, which is very important under urgent condition for flood monitoring

  10. Satellite monitoring at high spatial resolution of water bodies used for irrigation purposes

    Science.gov (United States)

    Baup, F.; Flanquart, S.; Marais-Sicre, C.; Fieuzal, R.

    2012-04-01

    In a changing climate context, with an increase of the need for food, it becomes increasingly important to improve our knowledge for monitoring agricultural surfaces by satellite for a better food management and to reduce the waste of natural resources (water storages and shortages, irrigation management, increase of soil and water salinity, soil erosion, threats on biodiversity). The main objective of this study is to evaluate the potentialities of multi-spectral and multi-resolution satellites for monitoring the temporal evolution of water bodies surfaces (mainly used for irrigation purposes). This analysis is based on the use of a series of images acquired between the years 2003 and 2011. The year 2010 is considered as a reference, with 110 acquisitions performed during the MCM'10 campaign (Multispectral Crop Monitoring 2010, http://www.cesbio.ups-tlse.fr/us/mcm.html). Those images are provided by 8 satellites (optical, thermal and RADAR) such as ALOS, TERRASAR-X, RADARSAT-2, FORMOSAT-2, SPOT-2, SPOT-4, SPOT-5, LANDSAT-5. The studied area is situated in the South-West of Toulouse in France; in a region governed by a temperate climate. The irrigated cultures represent almost 12% of the cultivated surface in 2009. The method consists in estimating the water bodies surfaces by using a generic approach suitable for all images, whatever the wavelength (optical, infrared, RADAR). The supervised parallelepiped classification allows discriminating four types of surfaces coverage: forests, water expanses, crops and bare soils. All RADAR images are filtered (Gamma) to reduce speckle effects and false detections of water bodies. In the context if the "South-West" project of the CESBIO laboratory, two spatial coverages are analyzed: SPOT 4 (4800km2) and FORMOSAT 2 (576km2). At these scales, 154 and 38 water bodies are identify. They respectively represent 4.85 km2 (0.10% of the image cover) and 2.06 km2 (0.36% of the image cover). Statistical analyses show that 8% of lakes

  11. Potential of a novel airborne hydrographic laser scanner for capturing shallow water bodies

    Science.gov (United States)

    Mandlburger, G.; Pfennigbauer, M.; Steinbacher, F.; Pfeifer, N.

    2012-04-01

    In this paper, we present the general design of a hydrographic laser scanner (prototype instrument) manufactured by the company Riegl Laser Measurement Systems in cooperation with the University of Innsbruck, Unit of Hydraulic Engineering. The instrument utilizes very short laser pulses (1 ns) in the green wavelength domain (λ=532 nm) capable of penetrating the water column. The backscattered signal is digitized in a waveform recorder at high frequency enabling sophisticated waveform processing, both, online during the flight and in post processing. In combination with a traditional topographic airborne laser scanner (λ=1500 nm) mounted on the same platform a complete hydrographic and topographic survey of the riparian foreland, the water surface and river bed can be carried out in a single campaign. In contrast to existing bathymetric LiDAR systems, the presented system uses only medium pulse energy but a high pulse repetition rate of up to 250 kHz and, thus, focuses on a detailed description of shallow water bodies under clear water conditions. Different potential fields of applications of the instrument (hydraulic modelling, hydro-morphology, hydro-biology, ecology, river restoration and monitoring) are discussed and the results of first real-world test flights in Austria and Germany are presented. It is shown that: (i) the high pulse repetition rate enables a point density on the ground of the water body of 10-20 pts/m2, (ii) the short laser pulses together with waveform processing enable a discrimination between water and ground reflections at a water depth of less than 25 cm, (iii) the combination of a topographic and hydrographic laser scanner enable the acquisition of the geometry data for hydraulic modeling in a single survey, thus, providing a much more homogeneous data basis compared to traditional techniques, and (iv) the high point density and the ranging accuracy of less than 10 cm enable a detailed and precise description of the river bed

  12. Interoceptive Awareness Skills for Emotion Regulation: Theory and Approach of Mindful Awareness in Body-Oriented Therapy (MABT

    Directory of Open Access Journals (Sweden)

    Cynthia J. Price

    2018-05-01

    Full Text Available Emotion regulation involves a coherent relationship with the self, specifically effective communication between body, mind, and feelings. Effective emotion regulation involves the ability to accurately detect and evaluate cues related to physiological reactions to stressful events, accompanied by appropriate regulation strategies that temper and influence the emotional response. There is compelling evidence demonstrating links between poor or disrupted awareness of sensory information, or interoceptive awareness, and difficulties with emotion regulation. This paper presents a framework, based on psychological and neurobiological research, for understanding how interoceptive awareness facilitates regulation and an integrated sense of self, and thus contributes to health and well-being. A mind-body therapeutic approach called mindful awareness in body-oriented therapy (MABT, uniquely designed to teach fundamental skills of interoceptive awareness, is described. MABT develops the distinct interoceptive awareness capacities of identifying, accessing, and appraising internal bodily signals that are identified in physiological models as the critical components of interoception for emotion regulation. The explanatory model is that the development of these key interoceptive capacities improves sensory (physical and emotional awareness, reduces distress, and improves regulation. Strategies for teaching and learning interoceptive awareness are not well-developed in mindfulness or psychotherapeutic approaches, particularly important for people who may have difficulty attending to interoceptive awareness due to stress, chronic pain or trauma. To address this issue, MABT provides an individualized protocol for scaffolding interoceptive awareness through a combination of psychoeducation and somatic approaches explicitly addressing difficulties with interoceptive processing. Clinical vignettes are included to provide exemplars of this approach and to highlight

  13. Boundary layer transition observations on a body of revolution with surface heating and cooling in water

    Science.gov (United States)

    Arakeri, V. H.

    1980-04-01

    Boundary layer flow visualization in water with surface heat transfer was carried out on a body of revolution which had the predicted possibility of laminar separation under isothermal conditions. Flow visualization was by in-line holographic technique. Boundary layer stabilization, including elimination of laminar separation, was observed to take place on surface heating. Conversely, boundary layer destabilization was observed on surface cooling. These findings are consistent with the theoretical predictions of Wazzan et al. (1970).

  14. SPH for impact force and ricochet behavior of water-entry bodies

    Science.gov (United States)

    Omidvar, Pourya; Farghadani, Omid; Nikeghbali, Pooyan

    The numerical modeling of fluid interaction with a bouncing body has many applications in scientific and engineering application. In this paper, the problem of water impact of a body on free-surface is investigated, where the fixed ghost boundary condition is added to the open source code SPHysics2D1 to rectify the oscillations in pressure distributions with the repulsive boundary condition. First, after introducing the methodology of SPH and the option of boundary conditions, the still water problem is simulated using two types of boundary conditions. It is shown that the fixed ghost boundary condition gives a better result for a hydrostatics pressure. Then, the dam-break problem, which is a bench mark test case in SPH, is simulated and compared with available data. In order to show the behavior of the hydrostatics forces on bodies, a fix/floating cylinder is placed on free surface looking carefully at the force and heaving profile. Finally, the impact of a body on free-surface is successfully simulated for different impact angles and velocities.

  15. Regulation of water resources for sustaining global future socioeconomic development

    Science.gov (United States)

    Chen, J.; SHI, H.; Sivakumar, B.

    2016-12-01

    With population projections indicating continued growth during this century, socio-economic problems (e.g., water, food, and energy shortages) will be most likely to occur, especially if proper planning, development, and management strategies are not adopted. In the present study, firstly, we explore the vital role of dams in promoting economic growth through analyzing the relationship between dams and Gross Domestic Product (GDP) at both global and national scales. Secondly, we analyze the current situation of global water scarcity based on the data representing water resources availability, dam development, and the level of economic development. Third, with comprehensive consideration of population growth as the major driving force, water resources availability as the basic supporting factor, and topography as the important constraint, this study addresses the question of dam development in the future and predicts the locations of future dams around the world.

  16. Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans

    Science.gov (United States)

    Olszewski, Pawel K.; Rozman, Jan; Jacobsson, Josefin A.; Rathkolb, Birgit; Strömberg, Siv; Hans, Wolfgang; Klockars, Anica; Alsiö, Johan; Risérus, Ulf; Becker, Lore; Hölter, Sabine M.; Elvert, Ralf; Ehrhardt, Nicole; Gailus-Durner, Valérie; Fuchs, Helmut; Fredriksson, Robert; Wolf, Eckhard; Klopstock, Thomas; Wurst, Wolfgang; Levine, Allen S.; Marcus, Claude; Hrabě de Angelis, Martin; Klingenspor, Martin; Schiöth, Helgi B.; Kilimann, Manfred W.

    2012-01-01

    Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes perinatal death. Here, we report that heterozygous KO mice haploinsufficient for Nbea have higher body weight due to increased adipose tissue mass. In several feeding paradigms, heterozygous KO mice consumed more food than wild-type (WT) controls, and this consumption was primarily driven by calories rather than palatability. Expression analysis of feeding-related genes in the hypothalamus and brainstem with real-time PCR showed differential expression of a subset of neuropeptide or neuropeptide receptor mRNAs between WT and Nbea+/− mice in the sated state and in response to food deprivation, but not to feeding reward. In humans, we identified two intronic NBEA single-nucleotide polymorphisms (SNPs) that are significantly associated with body-mass index (BMI) in adult and juvenile cohorts. Overall, data obtained in mice and humans suggest that variation of Nbea abundance or activity critically affects body weight, presumably by influencing the activity of feeding-related neural circuits. Our study emphasizes the importance of neural mechanisms in body weight control and points out NBEA as a potential risk gene in human obesity. PMID:22438821

  17. Determination of the Relative Sediment Concentration in Water Bodies Using Remote Sensing Methodology

    Directory of Open Access Journals (Sweden)

    Germán Vargas Cuervo

    2017-01-01

    Full Text Available Studies for the determination of the relative concentration of sediments (RCS in bodies of water such as rivers, marshes and river deltas require specialized equipment, field work and laboratory analyses of samples, all with high economic costs. Remote sensing, in regions of the optical electromagnetic spectrum, particularly in the visible range between 0.4 and 0.6 µm, shows radiometric contrasts associated with the relative concentration of sediments in water bodies. This work presents an analysis of the principal spectral, spatial and radiometric properties or characteristics of remote sensors for the determination of the relative concentration of sediments in bodies of water, a methodological process for its cartography at a given time or an established period of time. This cartography is based on digital processing of images rather than direct measurements in the field. Lastly, applications are presented for the delta coast of the southwestern area of the Colombian Caribbean between Barranquilla and Punta Piedra and in the lacustrine area of the Guajaro Reservoir and the Jobo and Capote Wetlands in the upper Canal del Dique, Colombia.

  18. Evaluation of significantly modified water bodies in Vojvodina by using multivariate statistical techniques

    Directory of Open Access Journals (Sweden)

    Vujović Svetlana R.

    2013-01-01

    Full Text Available This paper illustrates the utility of multivariate statistical techniques for analysis and interpretation of water quality data sets and identification of pollution sources/factors with a view to get better information about the water quality and design of monitoring network for effective management of water resources. Multivariate statistical techniques, such as factor analysis (FA/principal component analysis (PCA and cluster analysis (CA, were applied for the evaluation of variations and for the interpretation of a water quality data set of the natural water bodies obtained during 2010 year of monitoring of 13 parameters at 33 different sites. FA/PCA attempts to explain the correlations between the observations in terms of the underlying factors, which are not directly observable. Factor analysis is applied to physico-chemical parameters of natural water bodies with the aim classification and data summation as well as segmentation of heterogeneous data sets into smaller homogeneous subsets. Factor loadings were categorized as strong and moderate corresponding to the absolute loading values of >0.75, 0.75-0.50, respectively. Four principal factors were obtained with Eigenvalues >1 summing more than 78 % of the total variance in the water data sets, which is adequate to give good prior information regarding data structure. Each factor that is significantly related to specific variables represents a different dimension of water quality. The first factor F1 accounting for 28 % of the total variance and represents the hydrochemical dimension of water quality. The second factor F2 accounting for 18% of the total variance and may be taken factor of water eutrophication. The third factor F3 accounting 17 % of the total variance and represents the influence of point sources of pollution on water quality. The fourth factor F4 accounting 13 % of the total variance and may be taken as an ecological dimension of water quality. Cluster analysis (CA is an

  19. A global bioheat model with self-tuning optimal regulation of body temperature using Hebbian feedback covariance learning.

    Science.gov (United States)

    Ong, M L; Ng, E Y K

    2005-12-01

    In the lower brain, body temperature is continually being regulated almost flawlessly despite huge fluctuations in ambient and physiological conditions that constantly threaten the well-being of the body. The underlying control problem defining thermal homeostasis is one of great enormity: Many systems and sub-systems are involved in temperature regulation and physiological processes are intrinsically complex and intertwined. Thus the defining control system has to take into account the complications of nonlinearities, system uncertainties, delayed feedback loops as well as internal and external disturbances. In this paper, we propose a self-tuning adaptive thermal controller based upon Hebbian feedback covariance learning where the system is to be regulated continually to best suit its environment. This hypothesis is supported in part by postulations of the presence of adaptive optimization behavior in biological systems of certain organisms which face limited resources vital for survival. We demonstrate the use of Hebbian feedback covariance learning as a possible self-adaptive controller in body temperature regulation. The model postulates an important role of Hebbian covariance adaptation as a means of reinforcement learning in the thermal controller. The passive system is based on a simplified 2-node core and shell representation of the body, where global responses are captured. Model predictions are consistent with observed thermoregulatory responses to conditions of exercise and rest, and heat and cold stress. An important implication of the model is that optimal physiological behaviors arising from self-tuning adaptive regulation in the thermal controller may be responsible for the departure from homeostasis in abnormal states, e.g., fever. This was previously unexplained using the conventional "set-point" control theory.

  20. On the variability of the Priestley-Taylor coefficient over water bodies

    Science.gov (United States)

    Assouline, Shmuel; Li, Dan; Tyler, Scott; Tanny, Josef; Cohen, Shabtai; Bou-Zeid, Elie; Parlange, Marc; Katul, Gabriel G.

    2016-01-01

    Deviations in the Priestley-Taylor (PT) coefficient αPT from its accepted 1.26 value are analyzed over large lakes, reservoirs, and wetlands where stomatal or soil controls are minimal or absent. The data sets feature wide variations in water body sizes and climatic conditions. Neither surface temperature nor sensible heat flux variations alone, which proved successful in characterizing αPT variations over some crops, explain measured deviations in αPT over water. It is shown that the relative transport efficiency of turbulent heat and water vapor is key to explaining variations in αPT over water surfaces, thereby offering a new perspective over the concept of minimal advection or entrainment introduced by PT. Methods that allow the determination of αPT based on low-frequency sampling (i.e., 0.1 Hz) are then developed and tested, which are usable with standard meteorological sensors that filter some but not all turbulent fluctuations. Using approximations to the Gram determinant inequality, the relative transport efficiency is derived as a function of the correlation coefficient between temperature and water vapor concentration fluctuations (RTq). The proposed approach reasonably explains the measured deviations from the conventional αPT = 1.26 value even when RTq is determined from air temperature and water vapor concentration time series that are Gaussian-filtered and subsampled to a cutoff frequency of 0.1 Hz. Because over water bodies, RTq deviations from unity are often associated with advection and/or entrainment, linkages between αPT and RTq offer both a diagnostic approach to assess their significance and a prognostic approach to correct the 1.26 value when using routine meteorological measurements of temperature and humidity.

  1. To What Extent is Drinking Water Tested in Sub-Saharan Africa? A Comparative Analysis of Regulated Water Quality Monitoring

    Directory of Open Access Journals (Sweden)

    Rachel Peletz

    2016-03-01

    Full Text Available Water quality information is important for guiding water safety management and preventing water-related diseases. To assess the current status of regulated water quality monitoring in sub-Saharan Africa, we evaluated testing programs for fecal contamination in 72 institutions (water suppliers and public health agencies across 10 countries. Data were collected through written surveys, in-person interviews, and analysis of microbial water quality testing levels. Though most institutions did not achieve the testing levels specified by applicable standards or World Health Organization (WHO Guidelines, 85% of institutions had conducted some microbial water testing in the previous year. Institutions were more likely to meet testing targets if they were suppliers (as compared to surveillance agencies, served larger populations, operated in urban settings, and had higher water quality budgets (all p < 0.05. Our results indicate that smaller water providers and rural public health offices will require greater attention and additional resources to achieve regulatory compliance for water quality monitoring in sub-Saharan Africa. The cost-effectiveness of water quality monitoring should be improved by the application of risk-based water management approaches. Efforts to strengthen monitoring capacity should pay greater attention to program sustainability and institutional commitment to water safety.

  2. To What Extent is Drinking Water Tested in Sub-Saharan Africa? A Comparative Analysis of Regulated Water Quality Monitoring.

    Science.gov (United States)

    Peletz, Rachel; Kumpel, Emily; Bonham, Mateyo; Rahman, Zarah; Khush, Ranjiv

    2016-03-02

    Water quality information is important for guiding water safety management and preventing water-related diseases. To assess the current status of regulated water quality monitoring in sub-Saharan Africa, we evaluated testing programs for fecal contamination in 72 institutions (water suppliers and public health agencies) across 10 countries. Data were collected through written surveys, in-person interviews, and analysis of microbial water quality testing levels. Though most institutions did not achieve the testing levels specified by applicable standards or World Health Organization (WHO) Guidelines, 85% of institutions had conducted some microbial water testing in the previous year. Institutions were more likely to meet testing targets if they were suppliers (as compared to surveillance agencies), served larger populations, operated in urban settings, and had higher water quality budgets (all p water providers and rural public health offices will require greater attention and additional resources to achieve regulatory compliance for water quality monitoring in sub-Saharan Africa. The cost-effectiveness of water quality monitoring should be improved by the application of risk-based water management approaches. Efforts to strengthen monitoring capacity should pay greater attention to program sustainability and institutional commitment to water safety.

  3. Carbamazepine and diclofenac: removal in wastewater treatment plants and occurrence in water bodies.

    Science.gov (United States)

    Zhang, Yongjun; Geissen, Sven-Uwe; Gal, Carmen

    2008-11-01

    In the aquatic environment, pharmaceuticals have been widely found. Among them, carbamazepine and diclofenac were detected at the highest frequency. To evaluate the worldwide environmental impacts of both drugs, their global consumption volumes are estimated, based on the dose per capita. The metabolites of these pharmaceuticals are also of environmental concerns, especially trans-10,11-dihydro-10,11- dihydroxycarbamazepine (CBZ-diol) which probably has a similar concentration in water bodies to that of its parent drug. The removal efficiencies and mechanisms of both drugs in the wastewater treatment plants (WWTPs) are discussed with the actual state of knowledge. The occurrences of both drugs are examined in various water bodies including WWTP effluents, surface waters, groundwater and drinking water. Their chemical, physical and pharmacological properties are also addressed in context, which can largely influence their environmental behaviors. The ecotoxicological studies of both drugs imply that they do not easily cause acute toxic effects at their environmental concentrations. However their chronic effects need cautious attention.

  4. Growth hormone and prolactin responses during partial and whole body warm-water immersions.

    Science.gov (United States)

    Koska, J; Rovensky, J; Zimanova, T; Vigas, M

    2003-05-01

    To elucidate the role of core and skin thermoreceptors in the release of growth hormone (GH) and prolactin (PRL), a sequence of two experiments using whole-body (head-out) and partial (one forearm) hot water immersions was performed. Experiment 1: Nine healthy men were exposed to head-out and partial water immersions (25 min, 38-39 degrees C). Head-out immersion increased the core temperature (38.0 +/- 0.1 vs. 36.7 +/- 0.1 degrees C, P immersion the core temperature was slightly elevated (36.8 +/- 0.1 vs. 36.6 +/- 0.1, P immersed one forearm once in 39 degrees C and once in 38 degrees C water. The measurements were performed in 5-min intervals. The GH concentration increased gradually from the beginning of the immersions (min 10; 39 degrees C: 1.9 +/- 1.0 vs. 0.6 +/- 0.3 ng mL(-1), P Immersion in 38 degrees C water did not induce core temperature changes. Peripheral thermoreceptors are involved in GH release when the body is exposed to elevated environmental temperature while a substantial elevation of core temperature is a precondition of PRL release.

  5. Unintended consequences of regulating drinking water in rural Canadian communities: examples from Atlantic Canada.

    Science.gov (United States)

    Kot, Megan; Castleden, Heather; Gagnon, Graham A

    2011-09-01

    Studies that explore social capital and political will [corrected] in the context of safe drinking water provision in [corrected] Canada are limited. This paper presents findings from a study that examines the capacity of rural Canadian communities to attain regulatory compliance for drinking water. Interviews were conducted with water operators and managers in ten rural communities across Atlantic Canada to identify the burden of compliance arising from the implementation of, and adherence to, drinking water regulations. This research identifies the operator as being particularly burdened by regulatory compliance, often resulting in negative consequences including job stress and a strained relationship with the community they serve. Findings indicate that while regulations are vital to ensuring safe drinking water, not all communities have the resources in place to rise to the challenge of compliance. As a result, some communities are being negatively impacted by these regulations, rather than benefit from their intended positive effect. Copyright © 2011 Elsevier Ltd. All rights reserved.

  6. Ambition, Regulation and Reality. Complex use of land and water resources in Luwu, South Sulawesi, Indonesia

    NARCIS (Netherlands)

    Roth, D.

    2003-01-01

    In this book I present three case studies of the complex regulation of use of land and water resources in Luwu. Attention to the role of legalcomplexity -the existence of different sources and definitions of normative-legal regulation in

  7. Ambition, Regulation and Reality. Complex use of land and water resources in Luwu, South Sulawesi, Indonesia

    NARCIS (Netherlands)

    Roth, D.

    2003-01-01

    In this book I present three case studies of the complex regulation of use of land and water resources in Luwu. Attention to the role of legalcomplexity -the existence of different sources and definitions of normative-legal regulation in

  8. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production

    DEFF Research Database (Denmark)

    Shimazu, Tadahiro; Hirschey, Matthew D; Hua, Lan

    2010-01-01

    with SIRT3 and in vivo by overexpression of SIRT3. Deacetylation of HMGCS2 lysines 310, 447, and 473 by incubation with wild-type SIRT3 or by mutation to arginine enhances its enzymatic activity. Molecular dynamics simulations show that in silico deacetylation of these three lysines causes conformational...... changes of HMGCS2 near the active site. Mice lacking SIRT3 show decreased β-hydroxybutyrate levels during fasting. Our findings show SIRT3 regulates ketone body production during fasting and provide molecular insight into how protein acetylation can regulate enzymatic activity....

  9. Application of the regulations on pressurized components or light water reactor primary coolant circuits

    International Nuclear Information System (INIS)

    Barthelemy, F.; Menjon, G.

    1977-01-01

    This paper describes the philosophy and the provisions of the Order of 26 February 1974 concerning application of the regulations on pressurized components for light water reactor steam supply systems. The aim is to show how these regulations which differ from other regulations on pressurized components and is more detailed on many points, is applied in practice in France in the various stages of the design, construction and operation of PWRs. (NEA) [fr

  10. Effects of whole body cryotherapy and cold water immersion on knee skin temperature.

    Science.gov (United States)

    Costello, J T; Donnelly, A E; Karki, A; Selfe, J

    2014-01-01

    This study sought to (a) compare and contrast the effect of 2 commonly used cryotherapy treatments, 4 min of -110 °C whole body cryotherapy and 8 °C cold water immersion, on knee skin temperature and (b) establish whether either protocol was capable of achieving a skin temperature (cryotherapy (19.0±0.9 °C) compared to cold water immersion (20.5±0.6 °C). However, from 10 to 60 min post, the average, minimum and maximum skin temperatures were lower (p<0.05) following the cold water treatment. Finally, neither protocol achieved a skin temperature believed to be required to elicit an analgesic effect. © Georg Thieme Verlag KG Stuttgart · New York.

  11. Apparatus for use in predicting hydrocarbon potential of an earth formation underlying a body of water

    International Nuclear Information System (INIS)

    Demaison, G.J.; Kaplan, I.R.

    1984-01-01

    In a relatively quick, convenient and highly accurate technique for the determination of a carbonaceous gas, normally methane, contained in water samples collected at depth from a body of water overlying an earth formation to predict the hydrocarbon-containing potential of the earth formation, carbonaceous gaseous constituents liberated from the water are carried via an air stream to flow into and through an isotope trapping network where collection in microlitre amounts occurs. The isotope capture apparatus comprises a box-like structure formed from a series of panel members, front panel member intersecting the bottom panel member near the centre of the latter and carrying interconnected gas trapping and stripping sections, the structure also comprising a detachable lid connectable by means, for protection of sections. (author)

  12. Regulation of the peripheral body temperature by foods: a temperature decrease induced by the Japanese persimmon (kaki, Diospyros kaki).

    Science.gov (United States)

    Hibino, Gaku; Nadamoto, Tomonori; Fujisawa, Fumiko; Fushiki, Tohru

    2003-01-01

    We investigated whether the ingestion of the Japanese persimmon (kaki, Diospyros kaki) could lower the human peripheral body temperature. It was found that the temperatures recorded at the foot and wrist were depressed after kaki consumption compared to after the same amount of water consumption. The effects of ingesting freeze-dried kaki and eating a cookie (as its nutritional counterpart) containing the same amount of carbohydrate, protein, fat, and water were compared. A similar temperature-reducing effect of kaki was observed. The recovery of finger temperature after soaking the finger in ice-cooled water was also studied. The temperature recovery was delayed after kaki consumption. It was thus quantitatively demonstrated that ingesting kaki indeed had the effect of lowering (or repressing the rise) of the peripheral human body temperature, as has been traditionally believed in China for many hundreds of years.

  13. Depression and synaptic zinc regulation in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia.

    Science.gov (United States)

    Whitfield, David R; Vallortigara, Julie; Alghamdi, Amani; Hortobágyi, Tibor; Ballard, Clive; Thomas, Alan J; O'Brien, John T; Aarsland, Dag; Francis, Paul T

    2015-02-01

    Depression is a common symptom in dementia with Lewy bodies (DLB), Parkinson disease dementia (PDD), and Alzheimer disease (AD), yet its molecular basis remains unclear and current antidepressants do not appear to be effective. Cerebral zinc has been implicated in depression and synaptic dysfunction. We investigated the relationship between synaptic zinc regulation (for which zinc transporter 3 [ZnT3] is responsible) and depression in a large clinicopathologic study. We examined brains from people with PDD (N = 29), DLB (N = 27), and AD (N = 15) and comparison subjects without depression or dementia (N = 24). Individuals were categorized according to the presence and severity of depression (on a scale of 0-3) based on standardized assessments during life (principally Neuropsychiatric Inventory). Western blotting was used to determine ZnT3 levels in Brodmann area 9 (BA9), and regression analysis was used to determine the relationship between ZnT3 and depression. Reductions in ZnT3 in BA9 were significantly associated with elevated depression scores in the study cohort (β = -0.351, df = 93, t = -3.318 p = 0.0004). This association remained when only individuals with DLB, PDD, and no dementia or depression were examined (β = -0.347, df = 78, t = -3.271, p = 0.002) or only individuals with AD and no dementia or depression were examined (β = -0.433, df = 37, t = -2.924, p = 0.006). Although decreased zinc levels have been implicated in the genesis of depression in animal models and in major depressive disorder in humans, this study provides the first evidence of a role for zinc in depression in people with dementia and highlights zinc metabolism as a therapeutic target. Copyright © 2015 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

  14. Change of body height is regulated by thyroid hormone during metamorphosis in flatfishes and zebrafish.

    Science.gov (United States)

    Xu, Juan; Ke, Zhonghe; Xia, Jianhong; He, Fang; Bao, Baolong

    2016-09-15

    Flatfishes with more body height after metamorphosis should be better adapted to a benthic lifestyle. In this study, we quantified the changes in body height during metamorphosis in two flatfish species, Paralichthys olivaceus and Platichthys stellatus. The specific pattern of cell proliferation along the dorsal and ventral edge of the body to allow fast growth along the dorsal/ventral axis might be related to the change of body height. Thyroid hormone (T4 and T3) and its receptors showed distribution or gene expression patterns similar to those seen for the cell proliferation. 2-Mercapto-1-methylimidazole, an inhibitor of endogenous thyroid hormone synthesis, inhibited cell proliferation and decreased body height, suggesting that the change in body shape was dependent on the local concentration of thyroid hormone to induce cell proliferation. In addition, after treatment with 2-mercapto-1-methylimidazole, zebrafish larvae were also shown to develop a slimmer body shape. These findings enrich our knowledge of the role of thyroid hormone during flatfish metamorphosis, and the role of thyroid hormone during the change of body height during post-hatching development should help us to understand better the biology of metamorphosis in fishes. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. The Pituitary Gland and Age-Dependent Regulation of Body Composition

    NARCIS (Netherlands)

    van Beek, Andre P.; Wolffenbuttel, Bruce H. R.; Runge, Evelien; Trainer, Peter J.; Jonsson, Peter J.; Koltowska-Haggstrom, Maria

    Context: The prevalence of obesity is increased in hypopituitarism. In the general population, body mass index (BMI) and waist circumference increase with advancing age. It remains uncertain whether age-related changes in pituitary function contribute to the changes in body composition associated

  16. Possible effects of regulating hydroponic water temperature on plant ...

    African Journals Online (AJOL)

    Water temperature can affect many physiological processes during plant growth and development. Temperatures below or above optimum levels may influence plant metabolic activities positively or negatively. This may include accumulation of different metabolites such as phenolic compounds, reactive oxygen species ...

  17. Effect of selective withdrawal on the annual thermal regime of a deep water body

    International Nuclear Information System (INIS)

    Bocharov, O.B.; Zinov'ev, A.T.

    1993-01-01

    The construction of any large hydraulic structure leads to the occurrence of new ecosystems in the upper and lower pools of the hydro development. A study of scenarios of the development of these ecosystems and an investigation of the possibilities of minimizing the negative ecological consequences of waterpower engineering by means of mathematical modeling in many respects determine the quality of developing the scientific and technical project. For high-head hydroelectric stations, an effective tool for controlling the water quality in the upper and lower pools is the withdrawal of water form different horizons of the upper pool reservoir. Temperature stratification of a deep sluggish water body is modeled in a one-dimensional vertical approximation with the use of an improved method of describing fluid outflow. The effect of selective withdrawal on the annual thermal regime and temperature of the outflowing water was studied. The results obtained permit estimating the effect of selective withdrawal on the thermal regime of the upper pool of the planned hydro development and temperature of the water being discharged into the lower pool on the possibility, in principle, of the water temperature in the lower pool approaching the natural both in winter and summer

  18. Water and the Interior Structure of Terrestrial Planets and Icy Bodies

    Science.gov (United States)

    Monteux, J.; Golabek, G. J.; Rubie, D. C.; Tobie, G.; Young, E. D.

    2018-02-01

    Water content and the internal evolution of terrestrial planets and icy bodies are closely linked. The distribution of water in planetary systems is controlled by the temperature structure in the protoplanetary disk and dynamics and migration of planetesimals and planetary embryos. This results in the formation of planetesimals and planetary embryos with a great variety of compositions, water contents and degrees of oxidation. The internal evolution and especially the formation time of planetesimals relative to the timescale of radiogenic heating by short-lived 26Al decay may govern the amount of hydrous silicates and leftover rock-ice mixtures available in the late stages of their evolution. In turn, water content may affect the early internal evolution of the planetesimals and in particular metal-silicate separation processes. Moreover, water content may contribute to an increase of oxygen fugacity and thus affect the concentrations of siderophile elements within the silicate reservoirs of Solar System objects. Finally, the water content strongly influences the differentiation rate of the icy moons, controls their internal evolution and governs the alteration processes occurring in their deep interiors.

  19. Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight

    Directory of Open Access Journals (Sweden)

    Saira Hameed

    2017-06-01

    Full Text Available The obesity epidemic is a significant global health issue. Improved understanding of the mechanisms that regulate appetite and body weight will provide the rationale for the design of anti-obesity therapies. Thyroid hormones play a key role in metabolic homeostasis through their interaction with thyroid hormone receptors (TRs, which function as ligand-inducible transcription factors. The TR-beta isoform (TRβ is expressed in the ventromedial hypothalamus (VMH, a brain area important for control of energy homeostasis. Here, we report that selective knockdown of TRβ in the VMH of adult mice results in severe obesity due to hyperphagia and reduced energy expenditure. The observed increase in body weight is of a similar magnitude to murine models of the most extreme forms of monogenic obesity. These data identify TRβ in the VMH as a major physiological regulator of food intake and energy homeostasis.

  20. Economic Estimation of the Losses Caused by Surface Water Pollution Accidents in China From the Perspective of Water Bodies' Functions.

    Science.gov (United States)

    Yao, Hong; You, Zhen; Liu, Bo

    2016-01-22

    The number of surface water pollution accidents (abbreviated as SWPAs) has increased substantially in China in recent years. Estimation of economic losses due to SWPAs has been one of the focuses in China and is mentioned many times in the Environmental Protection Law of China promulgated in 2014. From the perspective of water bodies' functions, pollution accident damages can be divided into eight types: damage to human health, water supply suspension, fishery, recreational functions, biological diversity, environmental property loss, the accident's origin and other indirect losses. In the valuation of damage to people's life, the procedure for compensation of traffic accidents in China was used. The functional replacement cost method was used in economic estimation of the losses due to water supply suspension and loss of water's recreational functions. Damage to biological diversity was estimated by recovery cost analysis and damage to environmental property losses were calculated using pollutant removal costs. As a case study, using the proposed calculation procedure the economic losses caused by the major Songhuajiang River pollution accident that happened in China in 2005 have been estimated at 2263 billion CNY. The estimated economic losses for real accidents can sometimes be influenced by social and political factors, such as data authenticity and accuracy. Besides, one or more aspects in the method might be overestimated, underrated or even ignored. The proposed procedure may be used by decision makers for the economic estimation of losses in SWPAs. Estimates of the economic losses of pollution accidents could help quantify potential costs associated with increased risk sources along lakes/rivers but more importantly, highlight the value of clean water to society as a whole.

  1. Behavioral responses and fluid regulation in male rats after combined dietary sodium deficiency and water deprivation.

    Science.gov (United States)

    Lucia, Kimberly J; Curtis, Kathleen S

    2018-02-01

    Most investigators use a single treatment such as water deprivation or dietary sodium deficiency to evaluate thirst or sodium appetite, which underlie behavioral responses to body fluid challenges. The goal of the present experiments was to assess the effects of combined treatments in driving behaviors. Therefore, we evaluated the effect of combined overnight water deprivation and dietary sodium deficiency on water intake and salt intake by adult male rats in 2-bottle (0.5M NaCl and water) tests. Overnight water deprivation alone increased water intake, and 10days of dietary sodium deficiency increased 0.5M NaCl intake, with a secondary increase in water intake. During combined water deprivation and dietary sodium deficiency, water intake was enhanced and 0.5M NaCl was reduced, but not eliminated, suggesting that physiologically relevant behavioral responses persist. Nonetheless, the pattern of fluid intake was altered by the combined treatments. We also assessed the effect of these behaviors on induced deficits in body sodium and fluid volume during combined treatments and found that, regardless of treatment, fluid ingestion partially repleted the induced deficits. Finally, we examined urine volume and sodium excretion during dietary sodium deficiency with or without overnight water deprivation and found that, whether or not rats were water deprived, and regardless of water consumption, sodium excretion was minimal. Thus, the combination of water deprivation and dietary sodium deficiency appears to arouse drives that stimulate compensatory behavioral responses. These behaviors, in conjunction with physiological adaptations to the treatments, underlie body sodium and volume repletion in the face of combined water deprivation and dietary sodium deficiency. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice.

    Science.gov (United States)

    Laperrousaz, Elise; Moullé, Valentine S; Denis, Raphaël G; Kassis, Nadim; Berland, Chloé; Colsch, Benoit; Fioramonti, Xavier; Philippe, Erwann; Lacombe, Amélie; Vanacker, Charlotte; Butin, Noémie; Bruce, Kimberley D; Wang, Hong; Wang, Yongping; Gao, Yuanqing; Garcia-Caceres, Cristina; Prévot, Vincent; Tschöp, Matthias H; Eckel, Robert H; Le Stunff, Hervé; Luquet, Serge; Magnan, Christophe; Cruciani-Guglielmacci, Céline

    2017-07-01

    Regulation of energy balance involves the participation of many factors, including nutrients, among which are circulating lipids, acting as peripheral signals informing the central nervous system of the energy status of the organism. It has been shown that neuronal lipoprotein lipase (LPL) participates in the control of energy balance by hydrolysing lipid particles enriched in triacylglycerols. Here, we tested the hypothesis that LPL in the mediobasal hypothalamus (MBH), a well-known nucleus implicated in the regulation of metabolic homeostasis, could also contribute to the regulation of body weight and glucose homeostasis. We injected an adeno-associated virus (AAV) expressing Cre-green fluorescent protein into the MBH of Lpl-floxed mice (and wild-type mice) to specifically decrease LPL activity in the MBH. In parallel, we injected an AAV overexpressing Lpl into the MBH of wild-type mice. We then studied energy homeostasis and hypothalamic ceramide content. The partial deletion of Lpl in the MBH in mice led to an increase in body weight compared with controls (37.72 ± 0.7 g vs 28.46 ± 0.12, p < 0.001) associated with a decrease in locomotor activity. These mice developed hyperinsulinaemia and glucose intolerance. This phenotype also displayed reduced expression of Cers1 in the hypothalamus as well as decreased concentration of several C18 species of ceramides and a 3-fold decrease in total ceramide intensity. Conversely, overexpression of Lpl specifically in the MBH induced a decrease in body weight. Our study shows that LPL in the MBH is an important regulator of body weight and glucose homeostasis.

  3. Regulating water pollution in China and the European Union in terms of agricultural pollution

    NARCIS (Netherlands)

    Dai, Liping

    2015-01-01

    Regulatory instruments, are the most commonly used policy instruments in both China and the EU. This article explores how China and the EU establish their water quality objectives by regulation and how they design implementation strategies, with a particular focus of agricultural water pollution

  4. Griswold Tempered Water Flow Regulator Valves Used as Anti-Siphon Valves

    International Nuclear Information System (INIS)

    MISKA, C.

    2000-01-01

    FCV-1*22 and 1*23 are Griswold constant flow regulators used as anti-siphon valves in the tempered water system, they fail closed but valve cartridge orifice allows minimum flow to prevent loss of water from the MCO/CASK annulus

  5. Fact sheet: National primary drinking water regulations for lead and copper

    International Nuclear Information System (INIS)

    1991-05-01

    The Fact Sheet contains a summary of what the regulations will do, establish, and provide; regulatory impact in regards to benefits and costs; treatment technique requirements; tap water monitoring for lead and copper; water quality monitoring (other than lead and copper); monitoring schedules, regulatory schedules for large, medium-sized, and small systems

  6. A role for stomata in regulating water use efficiency in Populus x ...

    African Journals Online (AJOL)

    A role for stomata in regulating water use efficiency in Populus x euramericana and characterization of a related gene, PdERECTA. P Guo, X Xia, WL Yin. Abstract. The physiological mechanism of water use efficiency (WUE) remains elucidated, especially in poplar. We studied WUEi (instantaneous leaf transpiration ...

  7. Tightening water quality regulations produces an innovative separation technology

    International Nuclear Information System (INIS)

    Welther, P.B.; Broussard, P.C.

    1994-01-01

    The impact of the recent proposed changes in the water quality standards for offshore producing platforms is having a far reaching effect on the oil and gas industry. At a time when oil companies are cutting back their work forces and reducing capital outlays in order to stay competitive in the market, water treatment equipment manufacturing companies are aggressively seeking innovative and cost effective solutions to meet the environmental requirements. Necessity drives advancements in technology, so Monosep Corporation has accepted the challenge to improve induced gas flotation technology and to develop enhanced gravity separation. This system of improved gas flotation and enhanced gravity separation can be used to consistently meet the proposed new guideline of an ''oil and grease'' maximum monthly average of 29 mg/l (milligrams per liter) in the discharged water from offshore platforms. The results demonstrated in the field suggest that adding enhanced gravity separation upstream of existing gas flotation units can improve performance sufficient to meet the Proposed stricter discharge limits. For platforms that do not have efficient gas flotation units, the old units can be replaced or modified to include the new features improved gas flotation technology like the Veirsep. For those few platforms are having difficulty meeting the current discharge requirements, both a new improved gas flotation unit, as well as a more sophisticated upstream gravity separator like the Cyclosep, may need to be installed. Chemical additives are sometimes a required necessity, but must be used sparingly due to the potential for creating soluble oil problems

  8. Conserved microRNA miR-8 in fat body regulates innate immune homeostasis in Drosophila.

    Science.gov (United States)

    Choi, In Kyou; Hyun, Seogang

    2012-05-01

    Antimicrobial peptides (AMPs) constitute a major arm of the innate immune system across diverse organisms. In Drosophila, septic injury by microbial pathogens rapidly induces the production of the AMPs in fat body via well elucidated pathways such as Toll and IMD. However, several epithelial tissues were reported to locally express AMPs without septic injury via poorly characterized ways. Here, we report that microRNA miR-8 regulates the levels of AMPs basally expressed in Drosophila. The levels of AMPs such as Drosomycin and Diptericin are significantly increased in miR-8 null animals in non-pathogen stimulated conditions. Analysis of various larval tissues revealed that the increase of Drosomycin is fat body specific. Supporting this observation, re-introduction of miR-8 only in the fat body restored the altered AMP expression in miR-8 null flies. Although loss of miR-8 impedes PI3K in the fat body, inhibition of PI3K does not phenocopy the AMP expression of miR-8 null flies, indicating that miR-8 regulates AMP independently of PI3K. Together, our findings suggest a role of miR-8 in systemic immune homeostasis in generally non-pathogenic conditions in flies. Copyright © 2011 Elsevier Ltd. All rights reserved.

  9. Skeletal stiffening in an amphibious fish out of water is a response to increased body weight.

    Science.gov (United States)

    Turko, Andy J; Kültz, Dietmar; Fudge, Douglas; Croll, Roger P; Smith, Frank M; Stoyek, Matthew R; Wright, Patricia A

    2017-10-15

    Terrestrial animals must support their bodies against gravity, while aquatic animals are effectively weightless because of buoyant support from water. Given this evolutionary history of minimal gravitational loading of fishes in water, it has been hypothesized that weight-responsive musculoskeletal systems evolved during the tetrapod invasion of land and are thus absent in fishes. Amphibious fishes, however, experience increased effective weight when out of water - are these fishes responsive to gravitational loading? Contrary to the tetrapod-origin hypothesis, we found that terrestrial acclimation reversibly increased gill arch stiffness (∼60% increase) in the amphibious fish Kryptolebias marmoratus when loaded normally by gravity, but not under simulated microgravity. Quantitative proteomics analysis revealed that this change in mechanical properties occurred via increased abundance of proteins responsible for bone mineralization in other fishes as well as in tetrapods. Type X collagen, associated with endochondral bone growth, increased in abundance almost ninefold after terrestrial acclimation. Collagen isoforms known to promote extracellular matrix cross-linking and cause tissue stiffening, such as types IX and XII collagen, also increased in abundance. Finally, more densely packed collagen fibrils in both gill arches and filaments were observed microscopically in terrestrially acclimated fish. Our results demonstrate that the mechanical properties of the fish musculoskeletal system can be fine-tuned in response to changes in effective body weight using biochemical pathways similar to those in mammals, suggesting that weight sensing is an ancestral vertebrate trait rather than a tetrapod innovation. © 2017. Published by The Company of Biologists Ltd.

  10. Prolonged whole body immersion in cold water: hormonal and metabolic changes.

    Science.gov (United States)

    Smith, D J; Deuster, P A; Ryan, C J; Doubt, T J

    1990-03-01

    To characterize metabolic and hormonal responses during prolonged whole body immersion, 16 divers wearing dry suits completed four immersions in 5 degrees C water during each of two 5-day air saturation dives at 6.1 meters of sea water. One immersion began in the AM (1000 h) and one began in the PM (2200 h) to evaluate diurnal variations. Venous blood samples were obtained before and after completion of each immersion. Cortisol and ACTH levels demonstrated diurnal variation, with larger increases occurring after PM immersions. A greater than three-fold postimmersion increase occurred in norepinephrine (NE). There were significant increases in triiodothyronine (T3) uptake and epinephrine, but no change in T3, thyroxine, thyrotrophic hormone, and dopamine. Postimmersion free fatty acid levels increased 409% from preimmersion levels; glucose levels declined, and lactate increased significantly. Only changes in NE correlated significantly with changes in rectal temperature. In summary, when subjects are immersed in cold water for prolonged periods, with a slow rate of body cooling afforded by thermal protection and intermittent exercise, hormonal and metabolic changes occur that are similar in direction and magnitude to short-duration unprotected exposures. Except for cortisol and ACTH, none of the other measured variables exhibited diurnal alterations.

  11. Simultaneous occurrence of nitrates and sulfonamide antibiotics in two ground water bodies of Catalonia (Spain)

    Science.gov (United States)

    García-Galán, M. a. Jesús; Garrido, Teresa; Fraile, Josep; Ginebreda, Antoni; Díaz-Cruz, M. Silvia; Barceló, Damià

    2010-03-01

    SummaryIn the present work the occurrence of 19 selected sulfonamides, including one acetylated metabolite, was investigated in ground water samples taken from two ground water bodies in Catalonia (Plana de Vic and La Selva). Both include areas designated as nitrate vulnerable zones, according to Directive 91/676/EEC. A fully automated analytical methodology based on on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry (on-line SPE-LC-MS/MS) was developed for this purpose. The high selectivity and sensitivity achieved (limits of detection between 0.005 and 0.8 ng/L) permitted to demonstrate the ubiquity of these antibiotics in both ground water bodies. Results showed a wide range of concentrations, from 0.01 ng/L up to 3460.57 ng/L. Since sulfonamides are related to livestock veterinary practices, they can be used as a specific indicator of manure contamination. However, the presence of sulfonamides appeared not to be directly related to the concentration of nitrates, as it is reflected on the low correlation coefficients found.

  12. Alternatives to isotope ratio mass spectrometry for the measurement of deuterium content of body water

    International Nuclear Information System (INIS)

    Bluck, L.J.C.

    2000-01-01

    The measurement of breast milk intake using the isotope dilution techniques is now well established. The methodology involves the administration of a bolus of tracer followed by observation of the kinetics of its passage though the system. For example in the popular 'dose to the mother' method a dose of labeled water is administered to the mother, and over the following days samples of body fluids are taken and the concentration of tracer determined in order to establish the rate of loss of tracer from her body. Likewise samples are taken from the breast fed infant in order to determine the rates of tracer intake and subsequent loss. Deuterium is the tracer of choice for these experiments since it is non-radioactive, and therefore suitable for use in these vulnerable subject groups, and also because of its relative cheapness. Conventionally isotope ratio mass spectrometry (IRMS) has been used for the determination of the amount of deuterium in the body fluids. However this methodology is expensive (an instrument might typically cost US$ 150,000), and it requires a considerable amount of dedicated technical expertise for its operation. Consequently such instrumentation is not widely available, and this has limited the number and scope of studies using this technique. Recently there have been reports of possible alternative technologies for the determination of deuterium in body water which appear attractive because of the wider general availability of the equipment required. It is the purpose of this report to assess these reported methods for their suitability for breast milk intake measurements

  13. Correlations between cyanobacterial density and bacterial transformation to the viable but nonculturable (VBNC) state in four freshwater water bodies.

    Science.gov (United States)

    Chen, Huirong; Shen, Ju; Pan, Gaoshan; Liu, Jing; Li, Jiancheng; Hu, Zhangli

    2015-10-01

    Nutrient concentrations, phytoplankton density and community composition, and the viable but nonculturable (VBNC) state of heterotrophic bacteria were investigated in three connected reservoirs and a small isolated lake in South China to study the relationship between biotic and abiotic factors and the VBNC state in bacteria. Nutrient concentrations in the reservoirs increased in the direction of water flow, whereas Wenshan Lake was more eutrophic. Cyanobacterial blooms occurred in all four water bodies, with differing seasonal trends and dominant species. In Xili and Tiegang Reservoirs, the VBNC ratio (percent of VBNC state bacteria over total viable bacteria) was high for most of the year and negatively correlated with cyanobacterial density. Laboratory co-culture experiments were performed with four heterotrophic bacterial species isolated from Wenshan Lake (Escherichia coli, Klebsiella peneumoniae, Bacillus megaterium and Bacillus cereus) and the dominant cyanobacterial species (Microcystis aeruginosa). For the first three bacterial species, the presence of M. aeruginosa induced the VBNC state and the VBNC ratio was positively correlated with M. aeruginosa density. However, B. cereus inhibited M. aeruginosa growth. These results demonstrate that cyanobacteria could potentially regulate the transformation to the VBNC state of waterborne bacteria, and suggest a role for bacteria in cyanobacterial bloom initiation and termination.

  14. Studies on body composition of crossbred lambs determined by tritiated water with 50:50 roughage: concentrate ratio

    International Nuclear Information System (INIS)

    Hyder Ali, Md.; Saxena, K.K.; Shukla, V.P.; Ranjhan, S.K.

    1977-01-01

    Six Muzzaffarnagri x Dorset and six Muzzaffarnagri x Suffolk crossbred lambs were fed 50 : 50 roughage : concentrate ratio having ME of 2.1 Mcal/kg of ratio until they attained 25 kg body weight. Body composition of all the lambs was determined at 25 kg body weight by direct (slaughter method) and indirect (TOH technique) methods. The average corrected TOH space expressed on percent of body weight was found to be 70.48 +- 0.82 and average total body water estimated by desiccation, expressed on percent of body weight, was observed as 69.8 +- 1.08. Body composition of Muzzaffarnagri x Suffolk and Muzzaffarnagri x Dorset crossbred lambs was determined and expressed on empty body weight. The moisture content in Muzzaffarnagri x Dorset crossbred lambs was significantly higher (p<0.05) than in Muzzaffarnagri x Suffolk crossbred lambs but fat and protein contents were not significantly different in the two processes. (author)

  15. Dynamic monitoring of compliant bodies impacting the water surface through local strain measurements

    Science.gov (United States)

    Panciroli, Riccardo; Biscarini, Chiara; Jannelli, Elio; Ubertini, Filippo; Ubertini, Stefano

    2016-04-01

    The understanding and the experimental characterization of the evolution of impulsive loading is crucial in several fields in structural, mechanical and ocean engineering, naval architecture and aerospace. In this regards, we developed an experimental methodology to reconstruct the deformed shape of compliant bodies subjected to impulsive loadings, as those encountered in water entry events, starting from a finite number of local strain measurements performed through Fiber Bragg Gratings. The paper discusses the potential applications of the proposed methodology for: i) real-time damage detection and structural health monitoring, ii) fatigue assessment and iii) impulsive load estimation.

  16. SUMOylation regulates the nuclear mobility of CREB binding protein and its association with nuclear bodies in live cells

    International Nuclear Information System (INIS)

    Ryan, Colm M.; Kindle, Karin B.; Collins, Hilary M.; Heery, David M.

    2010-01-01

    The lysine acetyltransferase CREB binding protein (CBP) is required for chromatin modification and transcription at many gene promoters. In fixed cells, a large proportion of CBP colocalises to PML or nuclear bodies. Using live cell imaging, we show here that YFP-tagged CBP expressed in HEK293 cells undergoes gradual accumulation in nuclear bodies, some of which are mobile and migrate towards the nuclear envelope. Deletion of a short lysine-rich domain that contains the major SUMO acceptor sites of CBP abrogated its ability to be SUMO modified, and prevented its association with endogenous SUMO-1/PML speckles in vivo. This SUMO-defective CBP showed enhanced ability to co-activate AML1-mediated transcription. Deletion mapping revealed that the SUMO-modified region was not sufficient for targeting CBP to PML bodies, as C-terminally truncated mutants containing this domain showed a strong reduction in accumulation at PML bodies. Fluorescence recovery after photo-bleaching (FRAP) experiments revealed that YFP-CBPΔ998-1087 had a retarded recovery time in the nucleus, as compared to YFP-CBP. These results indicate that SUMOylation regulates CBP function by influencing its shuttling between nuclear bodies and chromatin microenvironments.

  17. SUMOylation regulates the nuclear mobility of CREB binding protein and its association with nuclear bodies in live cells

    Energy Technology Data Exchange (ETDEWEB)

    Ryan, Colm M.; Kindle, Karin B.; Collins, Hilary M. [Gene Regulation Group, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD (United Kingdom); Heery, David M., E-mail: david.heery@nottingham.ac.uk [Gene Regulation Group, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD (United Kingdom)

    2010-01-01

    The lysine acetyltransferase CREB binding protein (CBP) is required for chromatin modification and transcription at many gene promoters. In fixed cells, a large proportion of CBP colocalises to PML or nuclear bodies. Using live cell imaging, we show here that YFP-tagged CBP expressed in HEK293 cells undergoes gradual accumulation in nuclear bodies, some of which are mobile and migrate towards the nuclear envelope. Deletion of a short lysine-rich domain that contains the major SUMO acceptor sites of CBP abrogated its ability to be SUMO modified, and prevented its association with endogenous SUMO-1/PML speckles in vivo. This SUMO-defective CBP showed enhanced ability to co-activate AML1-mediated transcription. Deletion mapping revealed that the SUMO-modified region was not sufficient for targeting CBP to PML bodies, as C-terminally truncated mutants containing this domain showed a strong reduction in accumulation at PML bodies. Fluorescence recovery after photo-bleaching (FRAP) experiments revealed that YFP-CBP{Delta}998-1087 had a retarded recovery time in the nucleus, as compared to YFP-CBP. These results indicate that SUMOylation regulates CBP function by influencing its shuttling between nuclear bodies and chromatin microenvironments.

  18. Selected regulation of gastrointestinal acid-base secretion and tissue metabolism for the diamondback water snake and Burmese python.

    Science.gov (United States)

    Secor, Stephen M; Taylor, Josi R; Grosell, Martin

    2012-01-01

    Snakes exhibit an apparent dichotomy in the regulation of gastrointestinal (GI) performance with feeding and fasting; frequently feeding species modestly regulate intestinal function whereas infrequently feeding species rapidly upregulate and downregulate intestinal function with the start and completion of each meal, respectively. The downregulatory response with fasting for infrequently feeding snakes is hypothesized to be a selective attribute that reduces energy expenditure between meals. To ascertain the links between feeding habit, whole-animal metabolism, and GI function and metabolism, we measured preprandial and postprandial metabolic rates and gastric and intestinal acid-base secretion, epithelial conductance and oxygen consumption for the frequently feeding diamondback water snake (Nerodia rhombifer) and the infrequently feeding Burmese python (Python molurus). Independent of body mass, Burmese pythons possess a significantly lower standard metabolic rate and respond to feeding with a much larger metabolic response compared with water snakes. While fasting, pythons cease gastric acid and intestinal base secretion, both of which are stimulated with feeding. In contrast, fasted water snakes secreted gastric acid and intestinal base at rates similar to those of digesting snakes. We observed no difference between fasted and fed individuals for either species in gastric or intestinal transepithelial potential and conductance, with the exception of a significantly greater gastric transepithelial potential for fed pythons at the start of titration. Water snakes experienced no significant change in gastric or intestinal metabolism with feeding. Fed pythons, in contrast, experienced a near-doubling of gastric metabolism and a tripling of intestinal metabolic rate. For fasted individuals, the metabolic rate of the stomach and small intestine was significantly lower for pythons than for water snakes. The fasting downregulation of digestive function for pythons is

  19. Abundance and diversity of Odonata in temporary water bodies of Coimbatore and Salem districts in Tamil Nadu

    Directory of Open Access Journals (Sweden)

    R. Arulprakash

    2010-07-01

    Full Text Available Odonata diversity was assessed in 13 temporary water bodies of Coimbatore and Salem districts in Tamil Nadu. Assessment revealed the presence of 21 species of Odonata (14 species of Anisoptera and seven species of Zygoptera belonging to 17 genera under four families. Libellulidae (Anisoptera was represented by the maximum number of species and individuals. Pantala flavescens (Libellulidae was the most abundant among 21 species. Among the temporary water bodies, the maximum number of individuals as well as species was recorded from Utkulam tank (Coimbatore district. Odonata diversity was higher in Kamalapuram tanks 1 and 2 (Salem district and lower in Ukkadam tank (Coimbatore District. Diplacodes trivialis (Rambur, Orthetrum sabina (Drury and Pantala flavescens (Fabricius were identified as temporary water body specialists because of their presence in all the 13 temporary water bodies sampled.

  20. Diagnostic-Photographic Determination of Drag/Lift/Torque Coefficients of High Speed Rigid Body in Water Column

    National Research Council Canada - National Science Library

    Chu, Peter C; Fan, Chenwu; Gefken, Paul R

    2008-01-01

    Prediction of rigid body falling through water column with a high speed (such as Mk-84 bomb) needs formulas for drag/lift and torque coefficients, which depend on various physical processes such as supercavitation and bubbles...

  1. [Retaining and transformation of incoming soil N from highland to adjacent terrestrial water body in riparian buffer zone].

    Science.gov (United States)

    Wang, Qing-cheng; Yu, Hong-li; Yao, Qin; Han, Zhuang-xing; Qiao, Shu-liang

    2007-11-01

    Highland soil nitrogen can enter adjacent water body via erosion and leaching, being one of the important pollutants in terrestrial water bodies. Riparian buffer zone is a transitional zone between highland and its adjacent water body, and a healthy riparian buffer zone can retain and transform the incoming soil N through physical, biological, and biochemical processes. In this paper, the major pathways through which soil nitrogen enters terrestrial water body and the mechanisms the nitrogen was retained and transformed in riparian buffer zone were introduced systematically, and the factors governing the nitrogen retaining and transformation were analyzed from the aspects of hydrological processes, soil characters, vegetation features, and human activities. The problems existing in riparian buffer zone study were discussed, and some suggestions for the further study in China were presented.

  2. Probing the electronic structure of liquid water with many-body perturbation theory

    Science.gov (United States)

    Pham, Tuan Anh; Zhang, Cui; Schwegler, Eric; Galli, Giulia

    2014-03-01

    We present a first-principles investigation of the electronic structure of liquid water based on many-body perturbation theory (MBPT), within the G0W0 approximation. The liquid quasiparticle band gap and the position of its valence band maximum and conduction band minimum with respect to vacuum were computed and it is shown that the use of MBPT is crucial to obtain results that are in good agreement with experiment. We found that the level of theory chosen to generate molecular dynamics trajectories may substantially affect the electronic structure of the liquid, in particular, the relative position of its band edges and redox potentials. Our results represent an essential step in establishing a predictive framework for computing the relative position of water redox potentials and the band edges of semiconductors and insulators. Work supported by DOE/BES (Grant No. DE-SC0008938). Work at LLNL was performed under Contract DE-AC52-07NA27344.

  3. Commented list of rare and protected vascular plants of inland water bodies of Estonia

    Directory of Open Access Journals (Sweden)

    Helle Mäemets

    2016-10-01

    Full Text Available This presented overview of rare and protected hydrophytes, emergent plants and hygrophytes of inland water bodies of Estonia includes 60 species. In the commented list are indicated their position in the state protection categories I–III (last version in 2014, and under the Red List of Estonia (last version in 2008; marked are Natura 2000 species of the European Union. Most typical habitats for these rare species are: I. soft-water oligotrophic and semidystrophic lakes; II. mesotrophic lakes with Najas (Caulinia flexilis and Potamogeton rutilus; III. alkaline fens and wet meadows; IV. brackish or freshwater coastal lagoons; V. undamaged river stretches; VI. open shallow littoral of the largest lakes of Peipsi (Pskovsko-Chudskoe and of Võrtsjärv. Main threats of these habitats are briefly concerned, as well as the problem of conservation value of hybrids, based on the example of Sparganium species.

  4. Use of quality assurance criteria in the work of the regulating body: Cuban experience

    International Nuclear Information System (INIS)

    Sarabia Molina, I.

    1998-01-01

    This paper shows experiences obtained by CNSN, a competent organization in charge of radiological nuclear security and accounting and control of nuclear materials in the Republic of Cuba. It analyses quality assurance criteria while carrying out functions and responsibilities entrusted to it by the regulation in force. This paper also shows main advantages and disadvantages derived from the use of quality assurance methods in the regulation and control as well as on its evolution in time and also in the near future

  5. Drinking water regulations under the Safe Drinking Water Act. Fact sheet

    International Nuclear Information System (INIS)

    1990-12-01

    The fact sheet describes the requirements covered under the 1986 amendments to the Safe Drinking Water Act. Levels of various contaminants (including radio nuclides) are explained. Also discussed are the Surface Water Treatment Rule and the Total Coliforms Rule

  6. Impacts of operation of CVP regulating reservoirs on water temperature

    International Nuclear Information System (INIS)

    Vail, L.W.

    1996-01-01

    The Western Area Power Administration (Western) markets and transmits electric power throughout 15 western states. Western's Sierra Nevada Customer Service Region (Sierra Nevada Region) markets approximately 1,480 megawatts (MW) of firm power (and 100 MW of seasonal peaking capacity) from the Central Valley Project (CVP) and other sources and markets available nonfirm power from the Washoe Project. Western's mission is to sell and deliver electricity generated from CVP powerplants. The hydroelectric facilities of the CVP are operated by the Bureau of Reclamation (Reclamation). Reclamation manages and releases water in accordance with the various acts authorizing specific projects and with enabling legislation. Western's capacity and energy sales must be in conformance with the laws that govern its sale of electrical power. Further, Western's hydropower operations at each facility must comply with minimum and maximum flows and other constraints set by Reclamation, the U.S. Fish and Wildlife Service, or other agencies, acting in accord with law or policy

  7. Patterns, structures and regulations of domestic water cycle systems in China

    Science.gov (United States)

    Chu, Junying; Wang, Hao; Wang, Jianhua; Qin, Dayong

    2010-05-01

    management efforts typically fail in China, because the approach is generally narrowly-focused and fragmented. This paper put forward a total-process control framework following the water and pollutants (or nutrients) flows along the dualistic domestic water cycle process. Five key objectives of domestic water cycle system regulation are identified including water use safety, water use equity, water saving, wastewater reduction and nutrient recycling. Comprehensive regulatory framework regarding administrative, economic, technical and social measures is recommended to promote sustainable domestic water usage and demand management. Considering the relatively low affordability in rural area, economic measures should be mainly applied in urban domestic water systems and metropolitan domestic water systems. Engineering or technological measures which are suitable to the three domestic water cycle systems are discussed respectively.

  8. Longitudinal measurements of total body water and body composition in healthy volunteers by online breath deuterium measurement and other near-subject methods

    Czech Academy of Sciences Publication Activity Database

    Engel, B.; Španěl, Patrik; Smith, D.; Diskin, A. M.; Davis, S. J.

    2005-01-01

    Roč. 2, č. 3 (2005), s. 99-106 ISSN 1479-456X R&D Projects: GA ČR(CZ) GA203/00/0632 Institutional research plan: CEZ:AV0Z40400503 Keywords : total body water * deuterium isotope dilution * FA-MS * bio-impendance Subject RIV: CF - Physical ; Theoretical Chemistry

  9. Coliform and Metal Contamination in Lago de Colina, a Recreational Water Body in Chihuahua State, Mexico

    Science.gov (United States)

    Rubio-Arias, Hector; Rey, Nora I.; Quintana, Rey M.; Nevarez, G. Virginia; Palacios, Oskar

    2011-01-01

    Lago de Colina (Colina Lake) is located about 180 km south of the city of Chihuahua (Mexico), and during the Semana Santa (Holy Week) vacation period its recreational use is high. The objective of this study was to quantify coliform and heavy metal levels in this water body before and after the Holy Week vacation period in 2010. Twenty sampling points were randomly selected and two water samples were collected at each point near the surface (0.30 m) and at 1 m depth. After the Holy Week vacation the same twenty points were sampled at the same depths. Therefore, a total 80 water samples were analyzed for fecal and total coliforms and levels of the following metals: Al, As, B, Ca, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, Se, Si and Zn. It was hypothesized that domestic tourism contaminated this water body, and as a consequence, could have a negative impact on visitor health. An analysis of variance (ANOVA) study was performed for each element and its interactions considering a factorial design where factor A was sample date and factor B was sample depth. Fecal coliforms were only detected at eight sampling points in the first week, but after Holy Week, both fecal and total coliforms were detected at most sampling points. The concentrations of Al, B, Na, Ni and Se were only statistically different for factor A. The levels of Cr, Cu, K and Mg was different for both date and depth, but the dual factor interaction was not significant. The amount of Ca and Zn was statistically different due to date, depth and their interaction. No significant differences were found for any factor or the interaction for the elements As, Fe and Mn. Because of the consistent results, it is concluded that local tourism is contaminating the recreational area of Colina Lake, Chihuahua, Mexico. PMID:21776236

  10. Coliform and Metal Contamination in Lago de Colina, a Recreational Water Body in Chihuahua State, Mexico

    Directory of Open Access Journals (Sweden)

    Hector Rubio-Arias

    2011-06-01

    Full Text Available Lago de Colina (Colina Lake is located about 180 km south of the city of Chihuahua (Mexico, and during the Semana Santa (Holy Week vacation period its recreational use is high. The objective of this study was to quantify coliform and heavy metal levels in this water body before and after the Holy Week vacation period in 2010. Twenty sampling points were randomly selected and two water samples were collected at each point near the surface (0.30 m and at 1 m depth. After the Holy Week vacation the same twenty points were sampled at the same depths. Therefore, a total 80 water samples were analyzed for fecal and total coliforms and levels of the following metals: Al, As, B, Ca, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, Se, Si and Zn. It was hypothesized that domestic tourism contaminated this water body, and as a consequence, could have a negative impact on visitor health. An analysis of variance (ANOVA study was performed for each element and its interactions considering a factorial design where factor A was sample date and factor B was sample depth. Fecal coliforms were only detected at eight sampling points in the first week, but after Holy Week, both fecal and total coliforms were detected at most sampling points. The concentrations of Al, B, Na, Ni and Se were only statistically different for factor A. The levels of Cr, Cu, K and Mg was different for both date and depth, but the dual factor interaction was not significant. The amount of Ca and Zn was statistically different due to date, depth and their interaction. No significant differences were found for any factor or the interaction for the elements As, Fe and Mn. Because of the consistent results, it is concluded that local tourism is contaminating the recreational area of Colina Lake, Chihuahua, Mexico.

  11. Coliform and metal contamination in Lago de Colina, a recreational water body in Chihuahua State, Mexico.

    Science.gov (United States)

    Rubio-Arias, Hector; Rey, Nora I; Quintana, Rey M; Nevarez, G Virginia; Palacios, Oskar

    2011-06-01

    Lago de Colina (Colina Lake) is located about 180 km south of the city of Chihuahua (Mexico), and during the Semana Santa (Holy Week) vacation period its recreational use is high. The objective of this study was to quantify coliform and heavy metal levels in this water body before and after the Holy Week vacation period in 2010. Twenty sampling points were randomly selected and two water samples were collected at each point near the surface (0.30 m) and at 1 m depth. After the Holy Week vacation the same twenty points were sampled at the same depths. Therefore, a total 80 water samples were analyzed for fecal and total coliforms and levels of the following metals: Al, As, B, Ca, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, Se, Si and Zn. It was hypothesized that domestic tourism contaminated this water body, and as a consequence, could have a negative impact on visitor health. An analysis of variance (ANOVA) study was performed for each element and its interactions considering a factorial design where factor A was sample date and factor B was sample depth. Fecal coliforms were only detected at eight sampling points in the first week, but after Holy Week, both fecal and total coliforms were detected at most sampling points. The concentrations of Al, B, Na, Ni and Se were only statistically different for factor A. The levels of Cr, Cu, K and Mg was different for both date and depth, but the dual factor interaction was not significant. The amount of Ca and Zn was statistically different due to date, depth and their interaction. No significant differences were found for any factor or the interaction for the elements As, Fe and Mn. Because of the consistent results, it is concluded that local tourism is contaminating the recreational area of Colina Lake, Chihuahua, Mexico.

  12. Modeling the movement and equilibrium of water in the body of ruminants in relation to estimating body composition by deuterium oxide dilution

    International Nuclear Information System (INIS)

    Arnold, R.N.

    1986-01-01

    Deuterium oxide (D 2 O) dilution was evaluated for use in estimating body composition of ruminants. Empty body composition of cattle could not be accurately estimated by two- or three-compartment models when solved on the basis of clearance of D 2 O from blood. A 29-compartment blood-flow model was developed from measured blood flow rates and water volumes of tissues of sheep. The rates of equilibration of water in tissues that were simulated by the blood-flow model were much faster than actual rates measured in sheep and cattle. The incorporation of diffusion hindrances for movement of water into tissues enabled the blood flow model to simulate the measured equilibration rates in tissues, but the values of the diffusion coefficients were different for each tissue. The D 2 O-disappearance curve for blood simulated by the blood-flow model with diffusion limitations was comprised for four exponential components. The tissues and gastrointestinal tract contents were placed into five groups based upon the rate of equilibration. Water in the organs of the body equilibrated with water in blood within 3 min. Water in visceral fat, head, and some of the gastrointestinal tract tissues equilibrated within 8 to 16 min. Water in skeletal muscle, fat, and bone and the contents of some segments of the gastrointestinal tract equilibrated within 30 to 36 min. Water in the tissues and contents of the cecum and upper-large intestine equilibrated within 160 to 200 min. Water in ruminal tissue and contents equilibrated within 480 min

  13. Bacteriological quality of creeks and marine water bodies in North Goa: Ecosystem upkeep perspectives for tourism-related activities

    Digital Repository Service at National Institute of Oceanography (India)

    Ramaiah, N.; Sadhasivan, A.; Iyer, S.R.

    and other hygienic purposes). However, it may be used for gardening and flushing water closets. Keeping 100 colifarms per litre as the maximum permissible limit for 'using' natural water bodies, it becomes imperative to refer to Kazi and Nairy (2002... be needless to emphasize that increased amenities of sewage treatment plants, sanitation, and hygiene will not only reduce current levels of sewage discharge but also safeguard natural aquatic bodies, both surficial and underground. Social, economic, and 227...

  14. Pancreatic polypeptide is involved in the regulation of body weight in pima Indian male subjects

    DEFF Research Database (Denmark)

    Koska, Juraj; DelParigi, Angelo; de Courten, Barbora

    2004-01-01

    Pancreatic polypeptide (PP) is released from the pancreas in response to a meal. In humans, low-circulating PP levels have been observed in obesity, and administration of pharmacological doses of PP has been shown to decrease food intake. The aim of the present study was to investigate whether low...... circulating PP is associated with weight gain in Pima Indians. Plasma PP concentrations were measured after an overnight fast and 30 min after a standardized mixed meal in 33 nondiabetic male subjects who had a follow-up visit 4.9 +/- 2.5 years later. Cross-sectionally, fasting and postprandial PP levels were...... negatively associated with body size and adiposity. Prospectively, the change in PP response to the meal was negatively associated with the change in body weight (r = -0.53, P = 0.002). In contrast, a high fasting PP level was positively associated with change in body weight (r = 0.45, P = 0...

  15. Evaluation of the correlations for predicting evaporative loss from water body

    International Nuclear Information System (INIS)

    Yilmaz, T.P.; Aybar, H.S.

    1999-01-01

    Water evaporation (evaporation from here on) is a natural phenomenon that is important for system design and system safety in many engineering branches. Indeed, evaporative heat and mass loss are observed and calculated in very diverse situations, such as irrigation plants, water purification plants, cooling ponds, lakes, dams, swimming pools, health spas, management of liquid wastes as in evaporation pools, and spent fuel pools in nuclear power plants. There are a number of correlations obtained from experimental studies that predict the evaporative heat and mass loss from a water body. This study aims to summarize and to compare the existing evaporation correlations to determine the upper and lower bounding correlations for use in various thermal-hydraulic analyses of systems. Currently and widely used, six correlations found in the literature have been selected and tested using the major parameters of evaporation such as water temperature, air relative humidity, air velocity, and temperature. The comparison test cases show that ASHRAE (1991) and Ryan et al. (1974) equations result in the highest evaporative loss, while the Brady et al. (1969) equation provides the lowest evaporative loss in most conditions. Engineering designers may sometimes need the upper bound value of evaporative loss or sometimes the lower bound value for a conservative calculation. The authors conclude that using a single equation does not provide the conservative calculation for every situation and show which correlation gives the lower or upper bound for different conditions

  16. Physicochemical properties of macrogol ointment and emulsion ointment blend developed for regulation of water absorption.

    Science.gov (United States)

    Noda, Yasuhiro; Watanabe, Kazuya; Sanagawa, Akimasa; Sobajima, Yu; Fujii, Satoshi

    2011-10-31

    Pressure ulcers can form with excess pressure and shearing stress on skin tissue. Because pressure ulcer is often accompanies by exudates, selection of appropriate topical emulsion ointment is difficult. Blended ointments consisting of emulsion base and water-soluble base are clinically used for adjustment of wound moist environment. Because regulating the amount of wound exudates can enhance treatment efficacy, two new blended ointments were developed. LY-SL blended ointment consisted of lysozyme hydrochloride water-in-oil (w/o) emulsion (LY-cream) and sulfadiazine macrogol (polyethylene glycol) ointment (SL-pasta). TR-SL blended ointment consisted of tretinoin tocoferil oil-in-water (o/w) emulsion (TR-cream) and SL-pasta (TR-SL). LY-SL and TR-SL were applied to Franz diffusion cell with cellulose membranes for the evaluation of water absorption characteristics at 32 °C. Water absorption rate constants (mg/cm(2)/min(0.5)) were 12.5, 16.3 and 34.6 for LY-cream, TR-cream and SL-pasta, respectively. Water absorption rate constants for LY-SL and TR-SL (SL-pasta 70%) exhibited intermediate values of 21.2 and 27.2, as compared to each ointment alone, respectively. Because amount of water absorbed was linearly related to square root of time, it was suggested that water-absorbable macrogol was surrounded by oily ingredients forming matrix structure. This diffusion-limited structure may regulate water absorption capacity. This is the first report of physicochemical properties of macrogol ointment and emulsion ointment blend developed for regulation of water absorption. The blended ointment can properly regulate amount of exudates in wounds and may be useful for treatment of pressure ulcers. Copyright © 2011 Elsevier B.V. All rights reserved.

  17. Method of retrieving an object buried in the bottom of a body of water

    Energy Technology Data Exchange (ETDEWEB)

    van Steveninck, J

    1975-05-14

    In this method of retrieving an object buried in the bottom of a body of water, the object to be retrieved has a number of openings or nozzles, with the aid of at least some of which the object has been buried by fluidization in the bottom of a body of water, for example a fluidization device for burying a pipeline or a fluidization anchor. The method consists of supplying a gas to the buried object, allowing the gas to pass to and through openings or nozzles on the object in such a manner that the gas will be introduced into, and will refluidize the bottom material above the object, and raising the object. Experiments have shown that in this manner fluidization can be reestablished immediately, due to the low density and the low viscosity of the gas, whereafter the object due to the low resistance of the refluidized bottom material is easy to raise to the surface, even after the fluidization has been interrupted for a long period of time. Preferably, the gas used is air, since air is readily available; however, other gases can be used, if desired. (7 claims)

  18. Creatine Supplementation Increases Total Body Water in Soccer Players: a Deuterium Oxide Dilution Study.

    Science.gov (United States)

    Deminice, R; Rosa, F T; Pfrimer, K; Ferrioli, E; Jordao, A A; Freitas, E

    2016-02-01

    This study aimed to evaluate changes in total body water (TBW) in soccer athletes using a deuterium oxide dilution method and bioelectrical impedance (BIA) formulas after 7 days of creatine supplementation. In a double-blind controlled manner, 13 healthy (under-20) soccer players were divided randomly in 2 supplementation groups: Placebo (Pla, n=6) and creatine supplementation (CR, n=7). Before and after the supplementation period (0.3 g/kg/d during 7 days), TBW was determined by deuterium oxide dilution and BIA methods. 7 days of creatine supplementation lead to a large increase in TBW (2.3±1.0 L) determined by deuterium oxide dilution, and a small but significant increase in total body weight (1.0±0.4 kg) in Cr group compared to Pla. The Pla group did not experience any significant changes in TBW or body weight. Although 5 of 6 BIA equations were sensitive to determine TBW changes induced by creatine supplementation, the Kushner et al. 16 method presented the best concordance levels when compared to deuterium dilution method. In conclusion, 7-days of creatine supplementation increased TBW determined by deuterium oxide dilution or BIA formulas. BIA can be useful to determine TBW changes promoted by creatine supplementation in soccer athletes, with special concern for formula choice. © Georg Thieme Verlag KG Stuttgart · New York.

  19. Reproductive toxicity of a mixture of regulated drinking-water disinfection by-products in a multigenerational rat bioassay

    Science.gov (United States)

    BACKGROUND:Trihalomethanes (THMs) and haloaretic acids (HAAs) are regulated disinfection by-products (DBPs); their joint reproductive toxicity in drinking water is unknown.OBJECTIVE: We aimed to evaluate a drinking water mixture of the four regulated THMs and five regulated HAAs ...

  20. Effect of Aggression Regulation on Eating Disorder Pathology: RCT of a Brief Body and Movement Oriented Intervention.

    Science.gov (United States)

    Boerhout, Cees; Swart, Marte; Van Busschbach, Jooske T; Hoek, Hans W

    2016-03-01

    The objective of the study is to evaluate the effect of a brief body and movement oriented intervention on aggression regulation and eating disorder pathology for individuals with eating disorders. In a first randomized controlled trial, 40 women were allocated to either the aggression regulation intervention plus supportive contact or a control condition of supportive contact only. The intervention was delivered by a psychomotor therapist. Participants completed questionnaires on anger coping and eating disorder pathology. Independent samples t-tests were performed on the difference between pre-treatment and post-treatment scores. Twenty-nine participants completed questionnaires at pre-intervention and post-intervention. The intervention resulted in a significantly greater improvement of anger coping, as well as of eating disorder pathology. Results indicate that body and movement-oriented aggression regulation may be a viable add-on for treating eating disorders. It tackles a difficult to treat emotion which may have a role in blocking the entire process of treating eating disorders. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association.

  1. A whole-body model for glycogen regulation reveals a critical role for substrate cycling in maintaining blood glucose homeostasis.

    Directory of Open Access Journals (Sweden)

    Ke Xu

    2011-12-01

    Full Text Available Timely, and sometimes rapid, metabolic adaptation to changes in food supply is critical for survival as an organism moves from the fasted to the fed state, and vice versa. These transitions necessitate major metabolic changes to maintain energy homeostasis as the source of blood glucose moves away from ingested carbohydrates, through hepatic glycogen stores, towards gluconeogenesis. The integration of hepatic glycogen regulation with extra-hepatic energetics is a key aspect of these adaptive mechanisms. Here we use computational modeling to explore hepatic glycogen regulation under fed and fasting conditions in the context of a whole-body model. The model was validated against previous experimental results concerning glycogen phosphorylase a (active and glycogen synthase a dynamics. The model qualitatively reproduced physiological changes that occur during transition from the fed to the fasted state. Analysis of the model reveals a critical role for the inhibition of glycogen synthase phosphatase by glycogen phosphorylase a. This negative regulation leads to high levels of glycogen synthase activity during fasting conditions, which in turn increases substrate (futile cycling, priming the system for a rapid response once an external source of glucose is restored. This work demonstrates that a mechanistic understanding of the design principles used by metabolic control circuits to maintain homeostasis can benefit from the incorporation of mathematical descriptions of these networks into "whole-body" contextual models that mimic in vivo conditions.

  2. The temperature control and water quality regulation for steam generator secondary side hydrostatic test

    International Nuclear Information System (INIS)

    Xiao Bo; Liu Dongyong

    2014-01-01

    The secondary side hydrostatic test for the steam generator of M310 unit is to verify the pressure tightness of steam generator secondary side tube sheet and related systems. As for the importance of the steam generator, the water temperature and water quality of hydrostatic test has strict requirements. The discussion on the water temperature control and water quality regulation for the secondary loop hydrostatic test of Fuqing Unit 1 contribute greatly to the guiding work for the preparation of the steam generator pressure test for M310 unit. (authors)

  3. Phytoplankton diversity and their succession in water bodies of the Lednice park during 2002 season

    Directory of Open Access Journals (Sweden)

    Zohreh Ramezanpoor

    2004-01-01

    Full Text Available Phytoplankton communities of three water bodies in the Lednice park were studied from 22nd April till 1st October 2002. These water bodies are the Zámecký pond, Růžový pond and the Dyje River, which is water source of both ponds.Phytoplankton samples were taken every two weeks between 8 - 9 am. Collected phytoplankton samples were preserved with 4% formalin solution and Lugol solution (JJK and transported to the laboratory. They were determined and counted using inverted microscope. Water temperature, pH and dissolved oxygen were measured in the field using digital portable instruments. Total of 317 phytoplankton species were determined in this study.Heavy algal bloom was observed in the Zámecký pond in mid-summer coinciding with increase in water temperature. Fish diseases and partial mortality occurred during the period of algal bloom and unpleasant smell was dominant feature. A light algal bloom was also observed in the Růžový pond and the Dyje River nearly by the end of summer.The main algae species responsible for blue-green algae bloom were Anabaena flos-aquae, Microcystis aeruginosa, M. ichtyoblabe, M. flos-aquae and M. wesenbergii. Dissolved oxygen values varied between 3.4 - 19.5 mg l-1, pH ranged from 7.6 - 9.7. Secchi depth varied from 0- 65 cm in the Zámecký pond, 15-45 cm in the Růžový pond and 35-65 cm in the Dyje River. Concentration of total phosphate, nitrate and chlorophyll-a in the Dyje River before drainage into the Zámecký and Růžový pond verified heavy nutrient load (Total-P = 0.3, NO3- = 12 mg.l-1 of the river. Although the Dyje River is main water source for both ponds, presence of relatively different phytoplankton communities in these two ponds suggest that probably different nutrient sources might be responsible for differences in phytoplankton communities and eutrophication patterns in the Zámecký pond as compared to the Růžový pond.

  4. Maternal status regulates cortical responses to the body odor of newborns

    Directory of Open Access Journals (Sweden)

    Johan N Lundström

    2013-09-01

    Full Text Available Studies in non-human mammals have identified olfactory signals as prime mediators of mother-infant bonding and they have been linked with maternal attitudes and behavior in our own species as well. However, although the neuronal network processing infant cues has been studied for visual and auditory signals; to date, no such information exists for chemosensory signals. We contrasted the cerebral activity underlying the processing of infant odor properties in 15 women newly given birth for the first time and 15 women not given birth while smelling the body odor of unfamiliar 2 day-old newborn infants. Maternal status-dependent activity was demonstrated in the thalamus when exposed to the body odor of a newly born infant. Subsequent regions of interest analyses indicated that dopaminergic neostriatal areas are active in maternal-dependent responses. Taken together, these data suggests that body odors from 2 day-old newborns elicit activation in reward-related cerebral areas in women, regardless of their maternal status. These tentative data suggests that certain body odors might act as a catalyst for bonding mechanisms and highlights the need for future research on odor-dependent mother-infant bonding using parametric designs controlling for biological saliency and general odor perception effects.

  5. Regulated and Liberated Bodies of Schoolgirls in a Finnish Short Film from the 1950s

    Science.gov (United States)

    Nieminen, Marjo

    2018-01-01

    This article focuses on the bodies of schoolgirls as visualised and represented in a short film of Finnish secondary schools for girls in the 1950s. The film, "Oma tyttökouluni" ("My Own Girls' School") was released in 1957 and was screened in cinemas in advance of feature films. Although the short film was made in a…

  6. Improvements in X-band transmitter phase stability through Klystron body temperature regulation

    Science.gov (United States)

    Perez, R. M.

    1992-01-01

    This article describes the techniques used and experimental results obtained in improving transmitter stability by control of the klystron body temperature. Related work in the measurement of klystron phase control parameters (pushing factors) is also discussed. The contribution of wave guide temperature excursions to uplink phase stability is presented. Suggestions are made as to the direction of future work in this area.

  7. Glutamate mediates the function of melanocortin receptor 4 on sim1 neurons in body weight regulation

    Science.gov (United States)

    The melanocortin receptor 4 (MC4R) is a well-established mediator of body weight homeostasis. However, the neurotransmitter(s) that mediate MC4R function remain largely unknown; as a result, little is known about the second-order neurons of the MC4R neural pathway. Single-minded 1 (Sim1)-expressing ...

  8. Prolonged whole-body cold water immersion: fluid and ion shifts.

    Science.gov (United States)

    Deuster, P A; Smith, D J; Smoak, B L; Montgomery, L C; Singh, A; Doubt, T J

    1989-01-01

    To characterize fluid and ion shifts during prolonged whole-body immersion, 16 divers wearing dry suits completed four whole-body immersions in 5 degrees C water during each of two 5-day air saturation dives at 6.1 msw. One immersion was conducted at 1000 (AM) and one at 2200 (PM) so that diurnal variations could be evaluated. Fifty-four hours separated the immersions, which lasted up to 6 h; 9 days separated each air saturation dive. Blood was collected before and after immersion; urine was collected for 12 h before, during, and after immersion for a total of 24 h. Plasma volume decreased significantly and to the same extent (approximately 17%) during both AM and PM immersions. Urine flow increased by 236.1 +/- 38.7 and 296.3 +/- 52.0%, urinary excretion of Na increased by 290.4 +/- 89.0 and 329.5 +/- 77.0%, K by 245.0 +/- 73.4 and 215.5 +/- 44.6%, Ca by 211.0 +/- 31.4 and 241.1 +/- 50.4%, Mg by 201.4 +/- 45.9 and 165.3 +/- 287%, and Zn by 427.8 +/- 93.7 and 301.9 +/- 75.4% during AM and PM immersions, respectively, compared with preimmersion. Urine flow and K excretion were significantly higher during the AM than PM. In summary, when subjects are immersed in cold water for prolonged periods, combined with a slow rate of body cooling afforded by thermal protection and enforced intermittent exercise, there is diuresis, decreased plasma volume, and increased excretions of Na, K, Ca, Mg, and Zn.

  9. The regulation of diffuse pollution in the European Union: science, governance and water resource management

    Directory of Open Access Journals (Sweden)

    Sarah Hendry

    2012-11-01

    Full Text Available Reducing diffuse pollution is a perpetuating problem for environmental regulators. This paper will consider novel ways to regulate its impacts on the aquatic environment, with particular reference to rural landuse. It will look at the relationship between science, policy and law, and the contributions of integrated water resources management and governance at regional, national and river basin scales. Regulatory frameworks for water in the European Union will be explored, along with their implementation nationally in Scotland and at catchment scale in the Tweed river basin. It will conclude that regulation has a role to play, but that it is necessary to take a visionary holistic and integrated approach, nesting regulation within a governance framework that involves all stakeholders and takes full account of developing science and socio-economic drivers to meet environmental objectives.

  10. Datasets related to in-land water for limnology and remote sensing applications: distance-to-land, distance-to-water, water-body identifier and lake-centre co-ordinates.

    Science.gov (United States)

    Carrea, Laura; Embury, Owen; Merchant, Christopher J

    2015-11-01

    Datasets containing information to locate and identify water bodies have been generated from data locating static-water-bodies with resolution of about 300 m (1/360 ∘ ) recently released by the Land Cover Climate Change Initiative (LC CCI) of the European Space Agency. The LC CCI water-bodies dataset has been obtained from multi-temporal metrics based on time series of the backscattered intensity recorded by ASAR on Envisat between 2005 and 2010. The new derived datasets provide coherently: distance to land, distance to water, water-body identifiers and lake-centre locations. The water-body identifier dataset locates the water bodies assigning the identifiers of the Global Lakes and Wetlands Database (GLWD), and lake centres are defined for in-land waters for which GLWD IDs were determined. The new datasets therefore link recent lake/reservoir/wetlands extent to the GLWD, together with a set of coordinates which locates unambiguously the water bodies in the database. Information on distance-to-land for each water cell and the distance-to-water for each land cell has many potential applications in remote sensing, where the applicability of geophysical retrieval algorithms may be affected by the presence of water or land within a satellite field of view (image pixel). During the generation and validation of the datasets some limitations of the GLWD database and of the LC CCI water-bodies mask have been found. Some examples of the inaccuracies/limitations are presented and discussed. Temporal change in water-body extent is common. Future versions of the LC CCI dataset are planned to represent temporal variation, and this will permit these derived datasets to be updated.

  11. European perspectives on regional estimates of standing water bodies and the relevance of man-made ponds

    Science.gov (United States)

    Terasmaa, Jaanus; Bartout, Pascal; Marzecova, Agata; Touchart, Laurent; Koff, Tiiu; Choffel, Quentin; Kapanen, Galina; Maleval, Véronique; Millot, Camille; Qsair, Zoubida; Vandel, Egert

    2015-04-01

    Until recently, the small water bodies have been disregarded in the environmental management and protection policies. For example, the European Water Framework Directive 2000/60/EC proposes the threshold surface area of water bodies for typology and reporting as 50 ha. The inventories on state level or scientific studies took into account smaller water bodies (e.g. third higher than officially registered inventories. Also, in Estonia, the water bodies with a surface area below 1 ha are almost 50 times more abundant than those above 1 ha and 92% of all standing water bodies are smaller than 0.2 ha. Using the OpenStreetMap database we will discuss the differences between global inventories and EU-level analysis. We will show the alternative regional estimates of water bodies with the surface size threshold limit 0.01 ha which will illustrate the quantitative importance of very small often man-made ponds, which are however, abundant cultural heritage in many parts of Europe. Secondly, by comparing detailed national inventories compiled for France and Estonia, we will introduce usefulness of the the 'local to global' approach in which the local databases may significantly strengthen the precision of the regional (EU) level analysis. Overall, we will disss that all standing water bodies - including small and man-made ponds - play an important role in ecosystem services and require careful management to avoid hydrological and environmental deterioration. References: Verpoorter et al. (2014) Geophysical Research Letters, 41. Bartout & Touchart,(2013) Annales de Géographie, 691. Downing et al., (2006) Limnology and Oceanography, 51(5). Kuusisto & Raatikainen, (1988) Terra, 102. Meybeck, (1995) in Lerman et al., Physics and chemistry of lakes. Rjanžin, (2005) Priroda, 4.

  12. Water body and riparian buffer strip characteristics in a vineyard area to support aquatic pesticide exposure assessment.

    Science.gov (United States)

    Ohliger, Renja; Schulz, Ralf

    2010-10-15

    The implementation of a geodata-based probabilistic pesticide exposure assessment for surface waters in Germany offers the opportunity to base the exposure estimation on more differentiated assumptions including detailed landscape characteristics. Since these characteristics can only be estimated using field surveys, water body width and depth, hydrology, riparian buffer strip width, ground vegetation cover, existence of concentrated flow paths, and riparian vegetation were characterised at 104 water body segments in the vineyard region Palatinate (south-west Germany). Water body segments classified as permanent (n=43) had median values of water body width and depth of 0.9m and 0.06m, respectively, and the determined median width:depth ratio was 15. Thus, the deterministic water body model (width=1m; depth=0.3m) assumed in regulatory exposure assessment seems unsuitable for small water bodies in the study area. Only 25% of investigated buffer strips had a dense vegetation cover (>70%) and allow a laminar sheet flow as required to include them as an effective pesticide runoff reduction landscape characteristic. At 77 buffer strips, bordering field paths and erosion rills leading into the water body were present, concentrating pesticide runoff and consequently decreasing buffer strip efficiency. The vegetation type shrubbery (height>1.5m) was present at 57 (29%) investigated riparian buffer strips. According to their median optical vegetation density of 75%, shrubberies may provide a spray drift reduction of 72±29%. Implementing detailed knowledge in an overall assessment revealed that exposure via drift might be 2.4 and via runoff up to 1.6 fold higher than assumed by the deterministic approach. Furthermore, considering vegetated buffer strips only by their width leads to an underestimation of exposure by a factor of as much as four. Our data highlight that the deterministic model assumptions neither represent worst-case nor median values and therefore cannot

  13. Water bodies typology system: a Chilean case of scientific stakeholders and policy makers dialogue

    Directory of Open Access Journals (Sweden)

    Rodrigo Fuster

    2012-12-01

    Full Text Available The aim of this project was to obtain a scientists-validated Typology System, which would allow to classify the surface waters bodies in Chile and, therefore, to facilitate the environmental institutional water management in the country. For this, during the years 2009 and 2011, a Typology System for the surface freshwater bodies was developed for Chile based on the methodology described by the Water Framework Directive of the European Union, which was adapted to local features through the knowledge of limnologist experts in the country, as well as policy makers' experience and their management requirements . In a first stage, national ecoregions were developed and abiotic variables were defined to compose the Typology System. The resulted Typology System for lakes and rivers was generated following an a priori and top down approach to difference biocenosis, based on geomorphologic, hydrologic and physic criteria. In a second stage, the proposed Typology System was validated by experts and policy makers, in which process new arrangements were included in the system. The working methodology used for both stages was bibliographic review, interviews to local experts in biocenosis and workshops. It is specially highlighted the participative processes and discussions in which all the agents involved were present, all of which resulted in the creation of a valid system from a scientific point of view and a product that is applicable to the necessities of the environmental institutions of the country. This work represents a successful experience in the improvement of the communication between scientists and politicians in Chile, which is a relevant factor for the elaboration of more efficient and effective environmental policies, integrating not only management and economic issues, but also more technical aspects that can influence in the final success of any long term strategy. For this reason, the replication of this kind of experiences, as well as

  14. [100 years of drinking water regulation. Retrospective review, current situation and prospects].

    Science.gov (United States)

    Rakhmanin, Yu A; Krasovsky, G N; Egorova, N A; Mikhailova, R I

    2014-01-01

    There is considered the history of the development of legislative requirements to the regulation of the quality of drinking water in different countries and international organizations during the period from 1912 to the present time. In terms of comparative analysis there is analyzed the current state of regulatory frameworks of the Russian Federation, WHO, EU, Finland, the UK, Singapore, Australia, Japan, China, Nigeria, the United States and Canada in the field of providing favorable conditions of population drinking water use. There has been noted the significant progress in standardization of the content of the biogenic elements and chemical pollution of drinking water in the absence of uniform requirements to the composition and properties of drinking water globally, that is bound to the need to take into account the national peculiarities of drinking water supply within the separate countries. As promising directions for improving regulation of drinking water quality there are noted: the development of new standards for prioritized water pollution, periodic review ofstandards after appearance of the new scientific data on the biological action of substances, the use of the concept of risk, the harmonization of the normative values and the assessment of the possibility of introduction into the practice the one more criterion of profitableness of population water use--the bioenergetic state of the water.

  15. Co-regulation of water and K(+) transport in sunflower plants during water stress recovery.

    Science.gov (United States)

    Benlloch, Manuel; Benlloch-González, María

    2016-06-01

    16-day-old sunflower (Helianthus annuus L.) plants were subjected to deficit irrigation for 12 days. Following this period, plants were rehydrated for 2 days to study plant responses to post-stress recovery. The moderate water stress treatment applied reduced growth in all plant organs and the accumulation of K(+) in the shoot. After the rehydration period, the stem recovered its growth and reached a similar length to the control, an effect which was not observed in either root or leaves. Moreover, plant rehydration after water stress favored the accumulation of K(+) in the apical zone of the stem and expanding leaves. In the roots of plants under water stress, watering to field capacity, once the plants were de- topped, rapidly favored K(+) and water transport in the excised roots. This quick and short-lived response was not observed in roots of plants recovered from water stress for 2 days. These results suggest that the recovery of plant growth after water stress is related to coordinated water and K(+) transport from the root to the apical zone of the ​​stem and expanding leaves. This stimulation of K(+) transport in the root and its accumulation in the cells of the growing zones of the ​​stem must be one of the first responses induced in the plant during water stress recovery. Copyright © 2016 Elsevier GmbH. All rights reserved.

  16. Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet

    International Nuclear Information System (INIS)

    Jang, Woo Young; Bae, Ki Beom; Kim, Sung Hyun; Yu, Dong Hun; Kim, Hei Jung; Ji, Young Rae; Park, Seo Jin; Park, Si Jun; Kang, Min-Cheol; Jeong, Ja In; Park, Sang-Joon; Lee, Sang Gyu; Lee, Inkyu; Kim, Myoung Ok; Yoon, Duhak; Ryoo, Zae Young

    2014-01-01

    Highlights: • The expression of Jazf1 in the liver suppressed lipid accumulation. • Jazf1 significantly increases transcription of fatty acid synthase. • Jazf1 plays a critical role in the regulation of energy and lipid homeostasis. • Jazf1 associates the development of metabolic disorder. • Jazf1 may provide a new therapeutic target in the management of metabolic disorder. - Abstract: Jazf1 is a 27 kDa nuclear protein containing three putative zinc finger motifs that is associated with diabetes mellitus and prostate cancer; however, little is known about the role that this gene plays in regulation of metabolism. Recent evidence indicates that Jazf1 transcription factors bind to the nuclear orphan receptor TR4. This receptor regulates PEPCK, the key enzyme involved in gluconeogenesis. To elucidate Jazf1’s role in metabolism, we fed a 60% fat diet for up to 15 weeks. In Jazf1 overexpression mice, weight gain was found to be significantly decreased. The expression of Jazf1 in the liver also suppressed lipid accumulation and decreased droplet size. These results suggest that Jazf1 plays a critical role in the regulation of lipid homeostasis. Finally, Jazf1 may provide a new therapeutic target in the management of obesity and diabetes

  17. Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Woo Young; Bae, Ki Beom; Kim, Sung Hyun; Yu, Dong Hun; Kim, Hei Jung; Ji, Young Rae; Park, Seo Jin; Park, Si Jun; Kang, Min-Cheol; Jeong, Ja In [School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701 (Korea, Republic of); Park, Sang-Joon [College of Veterinary Medicine, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701 (Korea, Republic of); Lee, Sang Gyu [School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701 (Korea, Republic of); Lee, Inkyu [School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 700-842 (Korea, Republic of); Kim, Myoung Ok [School of Animal BT Sciences, Sangju Campus, Kyungpook National University, 386 Gajang-dong, Sangju, Gyeongsangbuk-do 742-211 (Korea, Republic of); Yoon, Duhak, E-mail: dhyoon@knu.ac.kr [School of Animal BT Sciences, Sangju Campus, Kyungpook National University, 386 Gajang-dong, Sangju, Gyeongsangbuk-do 742-211 (Korea, Republic of); Ryoo, Zae Young, E-mail: jaewoong64@hanmail.net [School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701 (Korea, Republic of)

    2014-02-14

    Highlights: • The expression of Jazf1 in the liver suppressed lipid accumulation. • Jazf1 significantly increases transcription of fatty acid synthase. • Jazf1 plays a critical role in the regulation of energy and lipid homeostasis. • Jazf1 associates the development of metabolic disorder. • Jazf1 may provide a new therapeutic target in the management of metabolic disorder. - Abstract: Jazf1 is a 27 kDa nuclear protein containing three putative zinc finger motifs that is associated with diabetes mellitus and prostate cancer; however, little is known about the role that this gene plays in regulation of metabolism. Recent evidence indicates that Jazf1 transcription factors bind to the nuclear orphan receptor TR4. This receptor regulates PEPCK, the key enzyme involved in gluconeogenesis. To elucidate Jazf1’s role in metabolism, we fed a 60% fat diet for up to 15 weeks. In Jazf1 overexpression mice, weight gain was found to be significantly decreased. The expression of Jazf1 in the liver also suppressed lipid accumulation and decreased droplet size. These results suggest that Jazf1 plays a critical role in the regulation of lipid homeostasis. Finally, Jazf1 may provide a new therapeutic target in the management of obesity and diabetes.

  18. Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat

    NARCIS (Netherlands)

    Mul, J.D.; van Boxtel, R.; Bergen, D.J.; Brans, M.A.; Brakkee, J.H.; Toonen, P.W.; Garner, K.M.; Adan, R.A.; Cuppen, E.

    2012-01-01

    Obesity is caused by an imbalance between energy intake and expenditure and has become a major health-care problem in western society. The central melanocortin system plays a crucial role in the regulation of feeding and energy expenditure, and functional loss of melanocortin receptor 4 (MC4R) is

  19. Distinct Skeletal Muscle Gene Regulation from Active Contraction, Passive Vibration, and Whole Body Heat Stress in Humans.

    Science.gov (United States)

    Petrie, Michael A; Kimball, Amy L; McHenry, Colleen L; Suneja, Manish; Yen, Chu-Ling; Sharma, Arpit; Shields, Richard K

    2016-01-01

    Skeletal muscle exercise regulates several important metabolic genes in humans. We know little about the effects of environmental stress (heat) and mechanical stress (vibration) on skeletal muscle. Passive mechanical stress or systemic heat stress are often used in combination with many active exercise programs. We designed a method to deliver a vibration stress and systemic heat stress to compare the effects with active skeletal muscle contraction. The purpose of this study is to examine whether active mechanical stress (muscle contraction), passive mechanical stress (vibration), or systemic whole body heat stress regulates key gene signatures associated with muscle metabolism, hypertrophy/atrophy, and inflammation/repair. Eleven subjects, six able-bodied and five with chronic spinal cord injury (SCI) participated in the study. The six able-bodied subjects sat in a heat stress chamber for 30 minutes. Five subjects with SCI received a single dose of limb-segment vibration or a dose of repetitive electrically induced muscle contractions. Three hours after the completion of each stress, we performed a muscle biopsy (vastus lateralis or soleus) to analyze mRNA gene expression. We discovered repetitive active muscle contractions up regulated metabolic transcription factors NR4A3 (12.45 fold), PGC-1α (5.46 fold), and ABRA (5.98 fold); and repressed MSTN (0.56 fold). Heat stress repressed PGC-1α (0.74 fold change; p muscle contraction. Vibration induced FOXK2 (p muscle contractions. Understanding these responses may assist in developing regenerative rehabilitation interventions to improve muscle cell development, growth, and repair.

  20. Spatial-temporal particularities of the ecological status of surface water bodies and pollution sources from Siret river basin

    Directory of Open Access Journals (Sweden)

    Dan DĂSCĂLIȚA

    2011-06-01

    Full Text Available The ecological status of surface water bodies from Siret River Basin is monitored systematically and spatial in accordance with the requirements of European Directives in the water area. Analysis temporary and spatial of qualitative and quantitative status of surface waters (rivers, lakes is achieved according to the specificities of each body of water resulting from physical and geographical conditions, climatic and hydromorphological regimes of river basin and from human activities.In order to know of those features, there are needed specific monitoring systems of water bodies. The parametersunderlying the assessment of ecological status of rivers and lakes are monitored systematically and temporary: daily, monthly, quarterly, annually, according to these characteristics. In this context, the daily variations in environmental condition, expresses the current status of surface waters. Monthly changes are correlated with climate change and characterize the seasonal variations. On annual basis are identified the mean, minimum and maximum for each parameter and the trends (increase, decrease, regularity, periodicity, changes, etc.. Based on this information, extensive to multiannual level, itcan achieve medium and long term forecasts and it might be issued the concepts and strategies for maintaining a balance and sustainable development of water resources.In this paper we have presented some issues related to the synthesis of spatial-temporal ecological status of water bodies managed by Administration of Siret Water Basin(ABAS. Results of studies on the ecological status of water bodies have been presented for the year 2009. Also, in this paper it was presented an evolution of the quantities ofpollutants from wastewater discharged in surface receptors and their purification by water users from of activity of ABAS area in 1999-2009 periods.

  1. Groundwater recharge in suburban areas of Hanoi, Vietnam: effect of decreasing surface-water bodies and land-use change

    Science.gov (United States)

    Kuroda, Keisuke; Hayashi, Takeshi; Do, An Thuan; Canh, Vu Duc; Nga, Tran Thi Viet; Funabiki, Ayako; Takizawa, Satoshi

    2017-05-01

    Over-exploited groundwater is expected to remain the predominant source of domestic water in suburban areas of Hanoi, Vietnam. In order to evaluate the effect on groundwater recharge, of decreasing surface-water bodies and land-use change caused by urbanization, the relevant groundwater systems and recharge pathways must be characterized in detail. To this end, water levels and water quality were monitored for 3 years regarding groundwater and adjacent surface-water bodies, at two typical suburban sites in Hanoi. Stable isotope (δ18O, δD of water) analysis and hydrochemical analysis showed that the water from both aquifers and aquitards, including the groundwater obtained from both the monitoring wells and the neighboring household tubewells, was largely derived from evaporation-affected surface-water bodies (e.g., ponds, irrigated farmlands) rather than from rivers. The water-level monitoring results suggested distinct local-scale flow systems for both a Holocene unconfined aquifer (HUA) and Pleistocene confined aquifer (PCA). That is, in the case of the HUA, lateral recharge through the aquifer from neighboring ponds and/or irrigated farmlands appeared to be dominant, rather than recharge by vertical rainwater infiltration. In the case of the PCA, recharge by the above-lying HUA, through areas where the aquitard separating the two aquifers was relatively thin or nonexistent, was suggested. As the decrease in the local surface-water bodies will likely reduce the groundwater recharge, maintaining and enhancing this recharge (through preservation of the surface-water bodies) is considered as essential for the sustainable use of groundwater in the area.

  2. Regulation of the water level in the steam generator using modal control

    International Nuclear Information System (INIS)

    Benoit, Guy.

    1981-11-01

    The nuclear power reactors type P.W.R. (900 MWe) have three steam generators (S.G.). The problem of the water level in the S.G. is analogous to that for a system with non-minimum phase. This causes a serious trouble for the stability of the regulation, which is actually realized by using the PID regulator. The first part of this study is devoted to construct a mathematical model which represents the S.G. This model is simulated on a digital computer, which order is six. The validity of this model is checked using actual measured signals which have been collected from the BUGEY III power reactor. In the second part, the mathematical representation for simulating the regulation of the level in the S.G. using the modal control is given. The simulation of the actual system is given in the third part. This actual system is composed from the S.G. as well as the PI and PID for regulating the water level. As results from this study, it can be concluded that, the modal control improves the regulation of the water level. The accuracy of the steam flow measurement at low rate is poor. So, the actual regulating system using the measurements has a reduced performance performance. The control modal which is represented in this study overcome this problem [fr

  3. The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes.

    Science.gov (United States)

    Blázquez, C; Woods, A; de Ceballos, M L; Carling, D; Guzmán, M

    1999-10-01

    The possible role of the AMP-activated protein kinase (AMPK), a highly conserved stress-activated kinase, in the regulation of ketone body production by astrocytes was studied. AMPK activity in rat cortical astrocytes was three times higher than in rat cortical neurons. AMPK in astrocytes was shown to be functionally active. Thus, incubation of astrocytes with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a cell-permeable activator of AMPK, stimulated both ketogenesis from palmitate and carnitine palmitoyltransferase I. This was concomitant to a decrease of intracellular malonyl-CoA levels and an inhibition of acetyl-CoA carboxylase/fatty acid synthesis and 3-hydroxy-3-methylglutaryl-CoA reductase/cholesterol synthesis. Moreover, in microdialysis experiments AICAR was shown to stimulate brain ketogenesis markedly. The effect of chemical hypoxia on AMPK and the ketogenic pathway was studied subsequently. Incubation of astrocytes with azide led to a remarkable drop of fatty acid beta-oxidation. However, activation of AMPK during hypoxia compensated the depression of beta-oxidation, thereby sustaining ketone body production. This effect seemed to rely on the cascade hypoxia --> increase of the AMP/ATP ratio --> AMPK stimulation --> acetyl-CoA carboxylase inhibition --> decrease of malonyl-CoA concentration --> carnitine palmitoyltransferase I deinhibition --> enhanced ketogenesis. Furthermore, incubation of neurons with azide blunted lactate oxidation, but not 3-hydroxybutyrate oxidation. Results show that (a) AMPK plays an active role in the regulation of ketone body production by astrocytes, and (b) ketone bodies produced by astrocytes during hypoxia might be a substrate for neuronal oxidative metabolism.

  4. The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature

    Science.gov (United States)

    Alawi, Khadija M.; Aubdool, Aisah A.; Liang, Lihuan; Wilde, Elena; Vepa, Abhinav; Psefteli, Maria-Paraskevi; Brain, Susan D.; Keeble, Julie E.

    2015-01-01

    Transient receptor potential vanilloid 1 (TRPV1) is involved in sensory nerve nociceptive signaling. Recently, it has been discovered that TRPV1 receptors also regulate basal body temperature in multiple species from mice to humans. In the present study, we investigated whether TRPV1 modulates basal sympathetic nervous system (SNS) activity. C57BL6/J wild-type (WT) mice and TRPV1 knockout (KO) mice were implanted with radiotelemetry probes for measurement of core body temperature. AMG9810 (50 mg/kg) or vehicle (2% DMSO/5% Tween 80/10 ml/kg saline) was injected intraperitoneally. Adrenoceptor antagonists or vehicle (5 ml/kg saline) was injected subcutaneously. In WT mice, the TRPV1 antagonist, AMG9810, caused significant hyperthermia, associated with increased noradrenaline concentrations in brown adipose tissue. The hyperthermia was significantly attenuated by the β-adrenoceptor antagonist propranolol, the mixed α-/β-adrenoceptor antagonist labetalol, and the α1-adrenoceptor antagonist prazosin. TRPV1 KO mice have a normal basal body temperature, indicative of developmental compensation. d-Amphetamine (potent sympathomimetic) caused hyperthermia in WT mice, which was reduced in TRPV1 KO mice, suggesting a decreased sympathetic drive in KOs. This study provides new evidence that TRPV1 controls thermoregulation upstream of the SNS, providing a potential therapeutic target for sympathetic hyperactivity thermoregulatory disorders.—Alawi, K. M., Aubdool, A. A., Liang, L., Wilde, E., Vepa, A., Psefteli, M.-P., Brain, S. D., Keeble, J. E. The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature. PMID:26136480

  5. Trials and tribulations of a new regulation: coal bed methane water well testing

    Energy Technology Data Exchange (ETDEWEB)

    Lintott, D.; Swyngedouw, C.; Schneider, E. [Norwest Labs, Edmonton, AB (Canada); Lintott, D.; Swyngedouw, C.; Schneider, E. [Bodycote Testing Group, Toronto, ON (Canada)

    2006-07-01

    As of January 2006, coalbed methane (CBM) activity in Alberta was at 3600 producing wells with the potential for 25,000 to 50,000 wells. Coalbed methane risks and regulations were discussed. Regulatory initiatives, politics of coalbed methane, and a regulatory timeline was provided and the trials of a new regulation were presented. Other topics of discussion included: methane sampling and analysis; dissolved methane in water; gas isotopes; routine water potability; microbiology testing; and, sulfate reducing bacteria (SRB)/iron-related bacteria (IRB) method validation. The results of the microbial testing were presented. Although relatively few positive coliforms in wells were analyzed, most wells demonstrated positive presence for iron and sulfate bacteria. It was recommended that further research be conducted to evaluate the water sulfide concentration/turbidity, along with other parameters with presence and concentration of SRB and IRB bacteria as an indication of poor water quality. refs., tabs.

  6. Body water handling in response to hypertonic-saline induced diuresis in fasting northern elephant seal pups (Mirounga angustirostris)

    Science.gov (United States)

    Ortiz, Rudy M.; Wade, Charles E.; Ortiz, C. Leo

    2003-01-01

    During natural fasting conditions in postweaned northern elephant seal (NES) (Mirounga angustirostris) pups, urinary water loss is minimized and percent total body water (TBW) is maintained constant. However, following infusion of hypertonic saline, glomerular filtration rate (GFR) and urine output increased in fasting pups. Therefore, we quantified the magnitude of the hypernatremia-induced diuresis relative to the animal's total body water (TBW) pool and the percentage of filtered water reabsorbed. Following a 24 h control period, naturally fasting NES pups (n=7) were infused (4 ml min(-1)) with hypertonic saline (16.7%) at a dose of 3 mmol NaCl kg(-1) body mass. Total body water was estimated prior to infusion by tritium dilution, GFR was estimated by standard creatinine clearance, and urine output (V) was measured for 24 h during the control and post infusion periods. Percentage of filtered water reabsorbed was calculated as (1-(V/GFR))x100. Twenty-four hours following the infusion, GFR (control: 69+/-12 ml min(-1) and post-infusion: 118+/-19 ml min(-1); mean+/-S.E.) increased 77+/-28% above control and the percentage of filtered water reabsorbed was decreased 0.4+/-0.1%. The increase in urine output (control: 218+/-47 ml d(-1) and post-infusion: 883+/-92 ml d(-1)) accounted for 1.7+/-0.2% of the pups' TBW. The hypernatremia-induced diuresis was accompanied by the loss of body water indicating the lack of water retention. Although the 77% increase in GFR was only associated with a 0.4% decrease in the percentage of filtered water reabsorbed, this decrease was significant enough to result in a 4-fold increase in urine output. Despite the observed diuresis, fasting NES pups appear to possess an efficient water recycling mechanism requiring only a small percentage of body water to excrete an excess salt load. This water recycling mechanism may allow pups to avoid negative perturbations in body water as they initiate feeding in a marine environment following the

  7. Numerical modeling of thermal regime in inland water bodies with field measurement data

    Science.gov (United States)

    Gladskikh, D.; Sergeev, D.; Baydakov, G.; Soustova, I.; Troitskaya, Yu.

    2018-01-01

    Modification of the program complex LAKE, which is intended to compute the thermal regimes of inland water bodies, and the results of its validation in accordance with the parameters of lake part of Gorky water reservoir are reviewed in the research. The modification caused changing the procedure of input temperature profile assignment and parameterization of surface stress on air-water boundary in accordance with the consideration of wind influence on mixing process. Also the innovation consists in combined methods of gathering meteorological parameters from files of global meteorological reanalysis and data of hydrometeorological station. Temperature profiles carried out with CTD-probe during expeditions in the period 2014-2017 were used for validation of the model. The comparison between the real data and the numerical results and its assessment based on time and temperature dependences in control points, correspondence of the forms of the profiles and standard deviation for all performed realizations are provided. It is demonstrated that the model reproduces the results of field measurement data for all observed conditions and seasons. The numerical results for the regimes with strong mixing are in the best quantitative and qualitative agreement with the real profiles. The accuracy of the forecast for the ones with strong stratification near the surface is lower but all specificities of the forms are correctly reproduced.

  8. Body cooling in human males by cold-water immersion after vigorous exercise.

    Science.gov (United States)

    McDonald, A; Goode, R C; Livingstone, S D; Duffin, J

    1984-03-01

    Five male subjects were immersed to neck level in a whole-body water calorimeter (water temperature 19 degrees C) on two occasions. One immersion was preceded by 30 min of exercise on a treadmill at 80% of the subjects' maximum heart rate, while the other was preceded by no exercise (control). Ventilation, oxygen consumption, hand-grip strength, and heat loss (measured by calorimetry) results showed no significant differences between resting and exercise trials. Minute ventilation and oxygen consumption increased during the immersion but the magnitude of the increase varied among subjects. There was a significant decrease is isometric hand-grip strength after 30 min of immersion. Rectal temperatures fell faster (0.031 degree C +/- 0.004 degree C/min) for exercised subjects than for controls (0.019 degree C +/- 0.005 degree C/min) between 10 and 45 min of immersion (P less than 0.01). It appears that vigorous preimmersion exercise may shorten survival time in cold water due to an increase in cooling rate.

  9. Distinct Skeletal Muscle Gene Regulation from Active Contraction, Passive Vibration, and Whole Body Heat Stress in Humans.

    Directory of Open Access Journals (Sweden)

    Michael A Petrie

    Full Text Available Skeletal muscle exercise regulates several important metabolic genes in humans. We know little about the effects of environmental stress (heat and mechanical stress (vibration on skeletal muscle. Passive mechanical stress or systemic heat stress are often used in combination with many active exercise programs. We designed a method to deliver a vibration stress and systemic heat stress to compare the effects with active skeletal muscle contraction.The purpose of this study is to examine whether active mechanical stress (muscle contraction, passive mechanical stress (vibration, or systemic whole body heat stress regulates key gene signatures associated with muscle metabolism, hypertrophy/atrophy, and inflammation/repair.Eleven subjects, six able-bodied and five with chronic spinal cord injury (SCI participated in the study. The six able-bodied subjects sat in a heat stress chamber for 30 minutes. Five subjects with SCI received a single dose of limb-segment vibration or a dose of repetitive electrically induced muscle contractions. Three hours after the completion of each stress, we performed a muscle biopsy (vastus lateralis or soleus to analyze mRNA gene expression.We discovered repetitive active muscle contractions up regulated metabolic transcription factors NR4A3 (12.45 fold, PGC-1α (5.46 fold, and ABRA (5.98 fold; and repressed MSTN (0.56 fold. Heat stress repressed PGC-1α (0.74 fold change; p < 0.05; while vibration induced FOXK2 (2.36 fold change; p < 0.05. Vibration similarly caused a down regulation of MSTN (0.74 fold change; p < 0.05, but to a lesser extent than active muscle contraction. Vibration induced FOXK2 (p < 0.05 while heat stress repressed PGC-1α (0.74 fold and ANKRD1 genes (0.51 fold; p < 0.05.These findings support a distinct gene regulation in response to heat stress, vibration, and muscle contractions. Understanding these responses may assist in developing regenerative rehabilitation interventions to improve muscle cell

  10. Regulation of Water Balance of the Plant from the Different Geo-Environmental Locations

    OpenAIRE

    Astghik R. Sukiasyan

    2016-01-01

    Under the drought stress condition, the plants would grow slower. Temperature is one of the most important abiotic factors which suppress the germination processes. However, the processes of transpiration are regulated directly by the cell water, which followed to an increase in volume of vacuoles. During stretching under the influence of water pressure, the cell goes into the state of turgor. In our experiments, lines of the semi-dental sweet maize of Armenian population from various zones o...

  11. Radioactivity in drinking water: regulations, monitoring results and radiation protection issues

    Directory of Open Access Journals (Sweden)

    Cristina Nuccetelli

    2012-12-01

    Full Text Available INTRODUCTION: Drinking waters usually contain several natural radionuclides: tritium, radon, radium, uranium isotopes, etc. Their concentrations vary widely since they depend on the nature of the aquifer, namely, the prevailing lithology and whether there is air in it or not. AIMS: In this work a broad overview of the radioactivity in drinking water is presented: national and international regulations, for limiting the presence of radioactivity in waters intended for human consumption; results of extensive campaigns for monitoring radioactivity in drinking waters, including mineral bottled waters, carried out throughout the world in recent years; a draft of guidelines for the planning of campaigns to measure radioactivity in drinking water proposed by the Environmental Protection Agency (ARPA of Lombardia.

  12. Weight self-regulation process in adolescence: the relationship between control weight attitudes, behaviors and body weight status

    Directory of Open Access Journals (Sweden)

    Jordi ePich

    2015-05-01

    Full Text Available Adolescents’ self-control weight behaviors were assessed (n= 1961; 12-17 years old; 2007-2008 in the Balearic Islands, Spain. The study analyzed the relationships between body weight status, body image and self-weight concern, and actual attempts to lose weight by restrained eating and/or increased exercising. In terms of regulatory focus theory (RFT, we considered that efforts to lose or to maintain weight (successful or failed would be motivated either by a promotion focus (to show an attractive body, a prevention focus (to avoid social rejection of fatness, or both. Results showed that 41% of overweight boys and 25% of obese boys stated that they had never made any attempt to lose weight, and 13% and 4% in females. Around half of overweight boys and around a quarter of obese boys stated that they were Not at all concerned about weight gain, and girls’ percentages decreased to 13% and 11% respectively. By contrast 57% of normal weight girls monitored their weight and stated that they had tried to slim at least once. Weight self-regulation in females attempted to combine diet and exercise, while boys relied almost exclusively on exercise. Apparent lack of consciousness of body weight status among overweight boys, and more important, subsequent absence of behaviors to reduce their weight clearly challenges efforts to prevent obesity. We argue that several causes may be involved in this outcome, including unconscious emotional (self-defense and cognitive (dissonance mechanisms driven by perceived social stigmatization of obesity. The active participation of social values of male and female body image (strong vs. pretty and the existence of social habituation to overweight are suggested. A better knowledge of psychosocial mechanisms underlying adolescent weight self-control may improve obesity epidemics.

  13. Is the regulation against potentially doped bodies in a fitness context socially sustainable?

    DEFF Research Database (Denmark)

    Thualagant, Nicole

    2015-01-01

    in an enhancement culture and, thus, in a logic of corporeal optimisation, users of the fitness centres develop different strategies in order to optimise their bodies, often with a desire for ‘more’ or ‘better’ performative health. Second, the actual policy is contradicting one of the basic values promulgated...... by the clubs offering sport for all; namely, the value of community and the sense of fellowship and shared values these clubs are believed to produce in a local community. By implementing a perspective on social sustainability this paper will explore how a focus on this particular social valorisation...

  14. The effect of direct heating and cooling of heat regulation centers on body temperature

    Science.gov (United States)

    Barbour, H. G.

    1978-01-01

    Experiments were done on 28 rabbits in which puncture instruments were left in the brain for 1-2 days until the calori-puncture hyperthermia had passed and the body temperature was again normal. The instrument remaining in the brain was then used as a galvanic electrode and a second fever was produced, this time due to the electrical stimulus. It was concluded that heat is a centrally acting antipyretic and that cold is a centrally acting stimulus which produces hyperpyrexia cold-induced fever.

  15. Identifying factors linked to the occurrence of alien gastropods in isolated woodland water bodies

    Science.gov (United States)

    Spyra, Aneta; Strzelec, Małgorzata

    2014-03-01

    Biological invasions are a significant component of human-caused global change and is widely regarded as one of the main threats to natural biodiversity. Isolated anthropogenic water bodies created in the areas that are deprived of natural freshwater habitats allow the survival and reproduction of alien species on newly settled sites. They are often small with water level fluctuations causing frequent environmental disturbances. The colonisation success may be the result of the rate of their degradation. The aims of the study were to determine the environmental conditions that affect the existence of alien species of gastropods in this type of aquatic environment and to examine whether the occurrence of non-native species affects the community structure of the native species. This study made it possible to group woodland ponds according to the occurrence of the three invasive species in snail communities and discuss the environmental conditions present in these pond types. Analysis of water properties emphasised the distinctiveness of the selected pond types. In ponds of the Potamopyrgus antipodarum type, we found the highest values of some parameters mainly hardness, conductivity, and content of calcium and chlorides, in contrast with the Physella acuta type, which were characterised by the lowest values except for phosphates and nitrites. In the Ferrissia fragilis type, we found the highest nitrate content. Data on the occurrence of alien species in different water environments play an important role in actions which are taken to prevent new invasions and spread of non-native species as well as to reduce future impacts of invaders.

  16. Areal changes of lentic water bodies within an agricultural basin of the Argentinean pampas. Disentangling land management from climatic causes.

    Science.gov (United States)

    Booman, Gisel Carolina; Calandroni, Mirta; Laterra, Pedro; Cabria, Fabián; Iribarne, Oscar; Vázquez, Pablo

    2012-12-01

    Wetland loss is a frequent concern for the environmental management of rural landscapes, but poor disentanglement between climatic and land management causes frequently constrains both proper diagnoses and planning. The aim of this study is to address areal changes induced by non-climatic factors on lentic water bodies (LWB) within an agricultural basin of the Argentinean Pampas, and the human activities that might be involved. The LWB of the Mar Chiquita basin (Buenos Aires province, Argentina) were mapped using Landsat images from 1998-2008 and then corrected for precipitation variability by considering the regional hydrological status on each date. LWB areal changes were statistically and spatially analyzed in relation to land use changes, channelization of streams, and drainage of small SWB in the catchment areas. We found that 12 % of the total LWB in the basin had changed (P climatic causes. During the evaluated decade, 30 % of the LWB that changed size had decreased while 70 % showed steady increases in area. The number of altered LWB within watersheds lineally increased or decreased according to the proportion of grasslands replaced by sown pastures, or the proportion of sown pastures replaced by crop fields, respectively. Drainage and channelization do not appear to be related to the alteration of LWB; however some of these hydrologic modifications may predate 1998, and thus earlier effects cannot be discarded. This study shows that large-scale changes in land cover (e.g., grasslands reduction) can cause a noticeable loss of hydrologic regulation at the catchment scale within a decade.

  17. Reduced precipitation over large water bodies in the Brazilian Amazon shown from TRMM data

    Science.gov (United States)

    Paiva, Rodrigo Cauduro Dias; Buarque, Diogo Costa; Clarke, Robin T.; Collischonn, Walter; Allasia, Daniel Gustavo

    2011-02-01

    Tropical Rainfall Measurement Mission (TRMM) data show lower rainfall over large water bodies in the Brazilian Amazon. Mean annual rainfall (P), number of wet days (rainfall > 2 mm) (W) and annual rainfall accumulated over 3-hour time intervals (P3hr) were computed from TRMM 3B42 data for 1998-2009. Reduced rainfall was marked over the Rio Solimões/Amazon, along most Amazon tributaries and over the Balbina reservoir. In a smaller test area, a heuristic argument showed that P and W were reduced by 5% and 6.5% respectively. Allowing for TRMM 3B42 spatial resolution, the reduction may be locally greater. Analyses of diurnal rainfall patterns showed that rainfall is lowest over large rivers during the afternoon, when most rainfall is convective, but at night and early morning the opposite occurs, with increased rainfall over rivers, although this pattern is less marked. Rainfall patterns reported from studies of smaller Amazonian regions therefore exist more widely.

  18. Effects of 17β-estradiol on emissions of greenhouse gases in simulative natural water body.

    Science.gov (United States)

    Ruan, Aidong; Zhao, Ying; Liu, Chenxiao; Zong, Fengjiao; Yu, Zhongbo

    2015-05-01

    Environmental estrogens are widely spread across the world and are increasingly thought of as serious contaminators. The present study looks at the influence of different concentrations of 17β-estradiol on greenhouse gas emissions (CO2 , CH4 , and N2 O) in simulated systems to explore the relationship between environmental estrogen-pollution and greenhouse gas emissions in natural water bodies. The present study finds that 17β-estradiol pollution in simulated systems has significant promoting effects on the emissions of CH4 and CO2 , although no significant effects on N2 O emissions. The present study indicates that 17β-estradiol has different effects on the different elements cycles; the mechanism of microbial ecology is under review. © 2015 SETAC.

  19. Hybrid Wing Body Model Identification Using Forced-Oscillation Water Tunnel Data

    Science.gov (United States)

    Murphy, Patrick C.; Vicroy, Dan D.; Kramer, Brian; Kerho, Michael

    2014-01-01

    Static and dynamic testing of the NASA 0.7 percent scale Hybrid Wing Body (HWB) configuration was conducted in the Rolling Hills Research Corporation water tunnel to investigate aerodynamic behavior over a large range of angle-of-attack and to develop models that can predict aircraft response in nonlinear unsteady flight regimes. This paper reports primarily on the longitudinal axis results. Flow visualization tests were also performed. These tests provide additional static data and new dynamic data that complement tests conducted at NASA Langley 14- by 22-Foot Subsonic Tunnel. HWB was developed to support the NASA Environmentally Responsible Aviation Project goals of lower noise, emissions, and fuel burn. This study also supports the NASA Aviation Safety Program efforts to model and control advanced transport configurations in loss-of-control conditions.

  20. Beneficial Autoimmunity at Body Surfaces – Immune Surveillance and Rapid Type 2 Immunity Regulate Tissue Homeostasis and Cancer

    Science.gov (United States)

    Dalessandri, Tim; Strid, Jessica

    2014-01-01

    Epithelial cells (ECs) line body surface tissues and provide a physicochemical barrier to the external environment. Frequent microbial and non-microbial challenges such as those imposed by mechanical disruption, injury or exposure to noxious environmental substances including chemicals, carcinogens, ultraviolet-irradiation, or toxins cause activation of ECs with release of cytokines and chemokines as well as alterations in the expression of cell-surface ligands. Such display of epithelial stress is rapidly sensed by tissue-resident immunocytes, which can directly interact with self-moieties on ECs and initiate both local and systemic immune responses. ECs are thus key drivers of immune surveillance at body surface tissues. However, ECs have a propensity to drive type 2 immunity (rather than type 1) upon non-invasive challenge or stress – a type of immunity whose regulation and function still remain enigmatic. Here, we review the induction and possible role of type 2 immunity in epithelial tissues and propose that rapid immune surveillance and type 2 immunity are key regulators of tissue homeostasis and carcinogenesis. PMID:25101088

  1. Beneficial autoimmunity at body surfaces - immune surveillance and rapid type 2 immunity regulate tissue homeostasis and cancer.

    Science.gov (United States)

    Dalessandri, Tim; Strid, Jessica

    2014-01-01

    Epithelial cells (ECs) line body surface tissues and provide a physicochemical barrier to the external environment. Frequent microbial and non-microbial challenges such as those imposed by mechanical disruption, injury or exposure to noxious environmental substances including chemicals, carcinogens, ultraviolet-irradiation, or toxins cause activation of ECs with release of cytokines and chemokines as well as alterations in the expression of cell-surface ligands. Such display of epithelial stress is rapidly sensed by tissue-resident immunocytes, which can directly interact with self-moieties on ECs and initiate both local and systemic immune responses. ECs are thus key drivers of immune surveillance at body surface tissues. However, ECs have a propensity to drive type 2 immunity (rather than type 1) upon non-invasive challenge or stress - a type of immunity whose regulation and function still remain enigmatic. Here, we review the induction and possible role of type 2 immunity in epithelial tissues and propose that rapid immune surveillance and type 2 immunity are key regulators of tissue homeostasis and carcinogenesis.

  2. Free Energy Landscapes of Alanine Oligopeptides in Rigid-Body and Hybrid Water Models.

    Science.gov (United States)

    Nayar, Divya; Chakravarty, Charusita

    2015-08-27

    Replica exchange molecular dynamics is used to study the effect of different rigid-body (mTIP3P, TIP4P, SPC/E) and hybrid (H1.56, H3.00) water models on the conformational free energy landscape of the alanine oligopeptides (acAnme and acA5nme), in conjunction with the CHARMM22 force field. The free energy landscape is mapped out as a function of the Ramachandran angles. In addition, various secondary structure metrics, solvation shell properties, and the number of peptide-solvent hydrogen bonds are monitored. Alanine dipeptide is found to have similar free energy landscapes in different solvent models, an insensitivity which may be due to the absence of possibilities for forming i-(i + 4) or i-(i + 3) intrapeptide hydrogen bonds. The pentapeptide, acA5nme, where there are three intrapeptide backbone hydrogen bonds, shows a conformational free energy landscape with a much greater degree of sensitivity to the choice of solvent model, though the three rigid-body water models differ only quantitatively. The pentapeptide prefers nonhelical, non-native PPII and β-sheet populations as the solvent is changed from SPC/E to the less tetrahedral liquid (H1.56) to an LJ-like liquid (H3.00). The pentapeptide conformational order metrics indicate a preference for open, solvent-exposed, non-native structures in hybrid solvent models at all temperatures of study. The possible correlations between the properties of solvent models and secondary structure preferences of alanine oligopeptides are discussed, and the competition between intrapeptide, peptide-solvent, and solvent-solvent hydrogen bonding is shown to be crucial in the relative free energies of different conformers.

  3. Water pollution - control of pollution regulations: water pollution from abandoned mines; pre-notification of mine abandonment consultation paper and draft regulations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-01

    The paper contains proposals to specify the content of the pre-abandonment notices which UK mine operators will be required to give in the future. The proposals are designed to enhance the Environment Agency`s ability to tackle water pollution from abandoned mines. They set out the precise contents of the notification, which mine operators will have to send to the Agency at least six months in advance of any intended abandonment. The regulations will cover coal and non-coal mines. Estimated compliance costs to business have been drawn up following consultation with the Department of Trade and Industry, the Health and Safety Executive, the Coal Authority and the Environment Agency. The regulations are due in late spring 1998.

  4. Regulation of hypothalamic neuronal sensing and food intake by ketone bodies and fatty acids.

    Science.gov (United States)

    Le Foll, Christelle; Dunn-Meynell, Ambrose A; Miziorko, Henri M; Levin, Barry E

    2014-04-01

    Metabolic sensing neurons in the ventromedial hypothalamus (VMH) alter their activity when ambient levels of metabolic substrates, such as glucose and fatty acids (FA), change. To assess the relationship between a high-fat diet (HFD; 60%) intake on feeding and serum and VMH FA levels, rats were trained to eat a low-fat diet (LFD; 13.5%) or an HFD in 3 h/day and were monitored with VMH FA microdialysis. Despite having higher serum levels, HFD rats had lower VMH FA levels but ate less from 3 to 6 h of refeeding than did LFD rats. However, VMH β-hydroxybutyrate (β-OHB) and VMH-to-serum β-OHB ratio levels were higher in HFD rats during the first 1 h of refeeding, suggesting that VMH astrocyte ketone production mediated their reduced intake. In fact, using calcium imaging in dissociated VMH neurons showed that ketone bodies overrode normal FA sensing, primarily by exciting neurons that were activated or inhibited by oleic acid. Importantly, bilateral inhibition of VMH ketone production with a 3-hydroxy-3-methylglutaryl-CoA synthase inhibitor reversed the 3- to 6-h HFD-induced inhibition of intake but had no effect in LFD-fed rats. These data suggest that a restricted HFD intake regimen inhibits caloric intake as a consequence of FA-induced VMH ketone body production by astrocytes.

  5. Behavioural consequences of an 8 Gy total body irradiation in mice: Regulation by interleukin-4

    International Nuclear Information System (INIS)

    Van der Meeren, A.; Lebaron-Jacobs, L.

    2001-01-01

    The effects of an 8 Gy γ total body irradiation (TBI) on exploration and locomotion activities as well as temperature were studied in C57BL6/J mice. Survival, body weight, and blood cell counts were also assessed in irradiated mice treated with placebo or interleukin (IL)-4. The efficacy of IL-4 treatment on improvement in exploration activity was evaluated. The study was carried out from 3 h to 30 days following exposure. Our results showed a biphasic response to irradiation concerning the exploration activity of mice. Irradiated mice had reduced activity as early as 3 h after exposure, with recovery of activity within 24 h. The exploration activity again decreased 4 days after irradiation and the recovery occurred slowly after day 17. IL-4 ameliorated the exploration status in mice in both phases. The locomotion activity was studied using a telemetry apparatus. A similar pattern to that of the exploration data was observed, with a minimal activity observed between days 13 and 17. A radiation-induced hypothermia was also noticed over the same time period. (author)

  6. Behavioural consequences of an 8 Gy total body irradiation in mice: Regulation by interleukin-4

    Energy Technology Data Exchange (ETDEWEB)

    Van der Meeren, A.; Lebaron-Jacobs, L. [Inst. de Protection et de Surete Nucleaire, Dept. de Protection de la sante de l' Homme et de Dosimetrie, Section Autonome de Radiobiologie Appliquee a la Medecine, IPSN, Fontenay-aux-Roses (France)

    2001-02-01

    The effects of an 8 Gy {gamma} total body irradiation (TBI) on exploration and locomotion activities as well as temperature were studied in C57BL6/J mice. Survival, body weight, and blood cell counts were also assessed in irradiated mice treated with placebo or interleukin (IL)-4. The efficacy of IL-4 treatment on improvement in exploration activity was evaluated. The study was carried out from 3 h to 30 days following exposure. Our results showed a biphasic response to irradiation concerning the exploration activity of mice. Irradiated mice had reduced activity as early as 3 h after exposure, with recovery of activity within 24 h. The exploration activity again decreased 4 days after irradiation and the recovery occurred slowly after day 17. IL-4 ameliorated the exploration status in mice in both phases. The locomotion activity was studied using a telemetry apparatus. A similar pattern to that of the exploration data was observed, with a minimal activity observed between days 13 and 17. A radiation-induced hypothermia was also noticed over the same time period. (author)

  7. Water ethics - a substitute for over-regulation of a scarce resource

    DEFF Research Database (Denmark)

    Harremoës, Poul

    2002-01-01

    is problematic and no easy solutions are in sight, but attention and awareness are essential. The ethical community has been expanded from a human dimension to include an ecological dimension, which aggravates the dilemma. There have been too many surprises in water quality development, due to unforeseen......” and more recently by “economical instruments”. Water ethics is an important, but frequently ignored element in regulation. Equity in availability and applicability of water is the important ethical issue at all levels, from local community to the global scale. The distribution of rights and duties...

  8. Chlorination or monochloramination: Balancing the regulated trihalomethane formation and microbial inactivation in marine aquaculture waters

    KAUST Repository

    Sanawar, Huma; Xiong, Yanghui; Alam, Aftab; Croue, Jean-Philippe; Hong, Pei-Ying

    2017-01-01

    at the lowest tested concentration of chlorine (1mg/L) and contact time (1h). Comparatively, regulated THMs concentration was only detectable at 30μg/L level in one of the three sets of monochloraminated marine aquaculture waters. The average log reduction

  9. Analysis of the natural factors of biological productivity of water bodies in the different landscapes of Karelia

    Directory of Open Access Journals (Sweden)

    Tekanova Elena Valentinovna

    2017-06-01

    Full Text Available Abiotic environmental factors of biological productivity were studied in seven lakes with low water exchange and a few inflows in different landscapes of Karelia (Russia. Lakes are not exposed to human impact. An indicator of the biological productivity is the phytoplankton photosynthesis rate calculated on the concentration of phosphorus in water. The water bodies vary from oligotrophic to mesotrophic according to their trophic level. Cluster and component analysis of chemicals was carried out, hydrological, morphometric and landscape characteristics of the lakes were also determined. It was shown that in the absence of anthropogenic influence the availability of phosphorus and trophic level of the studied lakes in the humid zone are determined by the water exchange, effluent per unit of water column, color of water and landscape features. The most productive water bodies are located on the fluvioglacial and moraine plains dominated by podsolic soils, which have a good flashing regime and soluble humus substances. These lakes are distinguished by a larger inflow of phosphorus forming a part of humus substances originated from the water-collecting area per unit of water column. Oligotrophic lakes are located in moraine and selga landscapes dominated by podbours and brown soils with a lot of humus slightly transformed. These lakes are characterized by less water exchange and drainage factor, and, accordingly, low values of phosphorus input and water color.

  10. Fatigue is a brain-derived emotion that regulates the exercise behavior to ensure the protection of whole body homeostasis

    Directory of Open Access Journals (Sweden)

    Timothy David Noakes

    2012-04-01

    Full Text Available An influential book written by A. Mosso in the late 19th century proposed that fatigue that at first sight might appear an imperfection of our body, is on the contrary one of its most marvellous perfections. The fatigue increasing more rapidly than the amount of work done saves us from the injury which lesser sensibility would involve for the organism so that muscular fatigue also is at bottom an exhaustion of the nervous system.It has taken more than a century to confirm Mosso’s idea that both the brain and the muscles alter their function during exercise and that fatigue is predominantly an emotion, part of a complex regulation, the goal of which is to protect the body from harm. Mosso’s ideas were supplanted in the English literature by those of A.V. Hill who believed that fatigue was the result of biochemical changes in the exercising limb muscles - peripheral fatigue - to which the central nervous system makes no contribution. The past decade has witnessed the growing realization that this brainless model cannot explain exercise performance. This article traces the evolution of our modern understanding of how the CNS regulates exercise specifically to insure that each exercise bout terminates whilst homeostasis is retained in all bodily systems. The brain uses the symptoms of fatigue as key regulators to insure that the exercise is completed before harm develops. These sensations of fatigue are unique to each individual and are illusionary since their generation is largely independent of the real biological state of the athlete at the time they develop. The model predicts that attempts to understand fatigue and to explain superior human athletic performance purely on the basis of the body’s known physiological and metabolic responses to exercise must fail since subconscious and conscious mental decisions made by winners and losers, in both training and competition, are the ultimate determinants of both fatigue and athletic performance.

  11. Environmental factors related to water level regulation - a comparative study in northern Finland

    International Nuclear Information System (INIS)

    Hellsten, S.K.

    1997-01-01

    The environmental conditions of the littoral zone were studied in the regulated Lake Ontojaervi and the unregulated Lake Lentua in northern Finland. The general aims of the study were to analyse the environmental factors related to water level regulation in the littoral zone and to produce information for assessing the effects of hydroelectric development in northern lakes. The study was basically carried out by comparing the littoral environments of the two study lakes. The most visible effects of water level regulation were related to the raised water level, which yielded erosion of sandy shores at the beginning of the regulation. Another effect of lake regulation was the altered fluctuation of the water level, which led to bottom instability and increased the size of the frozen and ice penetration zones. The effect of ice penetration was also easy to recognize on the shores of Lake Ontojaervi, where the surface sediment was frozen to a greater depth and across wider areas than in Lake Lentua. Below the freezing zone, the ice just pressed down on the sediment. The shores of Lake Ontojaervi were steeper than those of Lake Lentua, which affected the distribution of bottom types, with sandy bottoms being more common in Lake Lentua than in Lake Ontojaervi. The factors related to site exposure included effective fetch and the shape of the shoreline. The sedimentation level correlated only with the slope and was not predicted by the fetch or shape. The vertical reduction of light was estimated on the basis of water colour. The main environmental factors from the two lakes were used in a discriminant analysis to predict the bottom type distribution of the littoral (r 2 = 0.41). (orig.) 66 refs

  12. Environmental factors related to water level regulation - a comparative study in northern Finland

    Energy Technology Data Exchange (ETDEWEB)

    Hellsten, S K [VTT Communities and Infrastructure. Water Engineering and Ecotechnology, Oulu (Finland)

    1998-12-31

    The environmental conditions of the littoral zone were studied in the regulated Lake Ontojaervi and the unregulated Lake Lentua in northern Finland. The general aims of the study were to analyse the environmental factors related to water level regulation in the littoral zone and to produce information for assessing the effects of hydroelectric development in northern lakes. The study was basically carried out by comparing the littoral environments of the two study lakes. The most visible effects of water level regulation were related to the raised water level, which yielded erosion of sandy shores at the beginning of the regulation. Another effect of lake regulation was the altered fluctuation of the water level, which led to bottom instability and increased the size of the frozen and ice penetration zones. The effect of ice penetration was also easy to recognize on the shores of Lake Ontojaervi, where the surface sediment was frozen to a greater depth and across wider areas than in Lake Lentua. Below the freezing zone, the ice just pressed down on the sediment. The shores of Lake Ontojaervi were steeper than those of Lake Lentua, which affected the distribution of bottom types, with sandy bottoms being more common in Lake Lentua than in Lake Ontojaervi. The factors related to site exposure included effective fetch and the shape of the shoreline. The sedimentation level correlated only with the slope and was not predicted by the fetch or shape. The vertical reduction of light was estimated on the basis of water colour. The main environmental factors from the two lakes were used in a discriminant analysis to predict the bottom type distribution of the littoral (r{sup 2} = 0.41). (orig.) 66 refs.

  13. Adipose tissue (P)RR regulates insulin sensitivity, fat mass and body weight.

    Science.gov (United States)

    Shamansurova, Zulaykho; Tan, Paul; Ahmed, Basma; Pepin, Emilie; Seda, Ondrej; Lavoie, Julie L

    2016-10-01

    We previously demonstrated that the handle-region peptide, a prorenin/renin receptor [(P)RR] blocker, reduces body weight and fat mass and may improve insulin sensitivity in high-fat fed mice. We hypothesized that knocking out the adipose tissue (P)RR gene would prevent weight gain and insulin resistance. An adipose tissue-specific (P)RR knockout (KO) mouse was created by Cre-loxP technology using AP2-Cre recombinase mice. Because the (P)RR gene is located on the X chromosome, hemizygous males were complete KO and had a more pronounced phenotype on a normal diet (ND) diet compared to heterozygous KO females. Therefore, we challenged the female mice with a high-fat diet (HFD) to uncover certain phenotypes. Mice were maintained on either diet for 9 weeks. KO mice had lower body weights compared to wild-types (WT). Only hemizygous male KO mice presented with lower total fat mass, higher total lean mass as well as smaller adipocytes compared to WT mice. Although food intake was similar between genotypes, locomotor activity during the active period was increased in both male and female KO mice. Interestingly, only male KO mice had increased O2 consumption and CO2 production during the entire 24-hour period, suggesting an increased basal metabolic rate. Although glycemia during a glucose tolerance test was similar, KO males as well as HFD-fed females had lower plasma insulin and C-peptide levels compared to WT mice, suggesting improved insulin sensitivity. Remarkably, all KO animals exhibited higher circulating adiponectin levels, suggesting that this phenotype can occur even in the absence of a significant reduction in adipose tissue weight, as observed in females and, thus, may be a specific effect related to the (P)RR. (P)RR may be an important therapeutic target for the treatment of obesity and its associated complications such as type 2 diabetes.

  14. Dietary change, energy balance and body weight regulation among migrating students.

    Science.gov (United States)

    Reeves, S L; Henry, C J

    2000-11-01

    This study was conducted to examine how subjects modulate their food intake and energy balance when they migrate from a low energy density food intake pattern to one of high energy density. It was hypothesised that an increase in the energy density of food consumed would result in increased body weight of the migrating subjects unless food intake and energy balance could be modulated. Food selection, food intake, basal metabolic rate (BMR) and anthropometric measurements were made on 53 female and 56 male newly arrived overseas students. All subjects were from Malaysia, but the data was collected at Oxford Brookes University where the subjects were studying. Food intake using 3-day food diaries and food frequency questionnaires (FFQs). BMR and anthropometric measurements including body weight were measured on arrival in the UK and after 3 and 6 months' stay. Student's t-tests and analysis of variance (ANOVA) were used to compare the data. A significant difference (P foods consumed in Malaysia and after 3 and 6 months in the UK. There was also a significant decrease (P food selection due mainly to the lack of availability of certain foods in UK supermarkets. No significant differences were found in the BMR and anthropometric measurements made at the start of the study and later assessments. It appears that Malaysian students are able to remain in energy balance and are weight stable at least during the first 6 months of residence in the UK, despite the wider choice of energy dense food available. This suggests that at least in the short term, subjects are able to modulate their food intake in response to changes in the energy densities and free choice of food.

  15. Operator decision support system for integrated wastewater management including wastewater treatment plants and receiving water bodies.

    Science.gov (United States)

    Kim, Minsoo; Kim, Yejin; Kim, Hyosoo; Piao, Wenhua; Kim, Changwon

    2016-06-01

    An operator decision support system (ODSS) is proposed to support operators of wastewater treatment plants (WWTPs) in making appropriate decisions. This system accounts for water quality (WQ) variations in WWTP influent and effluent and in the receiving water body (RWB). The proposed system is comprised of two diagnosis modules, three prediction modules, and a scenario-based supporting module (SSM). In the diagnosis modules, the WQs of the influent and effluent WWTP and of the RWB are assessed via multivariate analysis. Three prediction modules based on the k-nearest neighbors (k-NN) method, activated sludge model no. 2d (ASM2d) model, and QUAL2E model are used to forecast WQs for 3 days in advance. To compare various operating alternatives, SSM is applied to test various predetermined operating conditions in terms of overall oxygen transfer coefficient (Kla), waste sludge flow rate (Qw), return sludge flow rate (Qr), and internal recycle flow rate (Qir). In the case of unacceptable total phosphorus (TP), SSM provides appropriate information for the chemical treatment. The constructed ODSS was tested using data collected from Geumho River, which was the RWB, and S WWTP in Daegu City, South Korea. The results demonstrate the capability of the proposed ODSS to provide WWTP operators with more objective qualitative and quantitative assessments of WWTP and RWB WQs. Moreover, the current study shows that ODSS, using data collected from the study area, can be used to identify operational alternatives through SSM at an integrated urban wastewater management level.

  16. USING LANDSAT IMAGES IN MAPPING AND MONITORING WATER BODIES IN MĂGURA BASIN

    Directory of Open Access Journals (Sweden)

    MEREUȚĂ M.

    2015-03-01

    Full Text Available The work is part of a wider range of interdisciplinary studies undertaken in Măgura catchment, a right-side tributary of Bahlui River. The Măgura River flows from the massif Great Hill-Hârlău. Before the year 2000 there were 11 lakes, and today are only 4. The purpose of this project is to determine the accuracy of the simple techniques in digital image processing for mapping and monitoring lakes and wetlands. Landsat 7 ETM + and Landsat 8 OLI TIRS data sets are used. The paper highlights the bands’ thematic classification accuracy using minimum technical and digital (software resources. The water bodies’ delineated boundaries of each digital classification procedure were compared with the limits obtained by digitizing the topographical plans (1973 and aerial images (2008. The comparisons show that the Landsat data can be used to map accurately the water bodies. It is a simple method of determining the silting degree, especially for lakes with an area of at least 1 ha. Măgura basin has a high archaeological potential (prehistory up to the modern period, part of the national and international cultural heritage. Creating a GIS database, in order to analyze the human-environment relationship, began by studying the hydrological variables. This factor has an important role in the society’s development, both prehistoric and current.

  17. Objective classification of ecological status in marine water bodies using ecotoxicological information and multivariate analysis.

    Science.gov (United States)

    Beiras, Ricardo; Durán, Iria

    2014-12-01

    Some relevant shortcomings have been identified in the current approach for the classification of ecological status in marine water bodies, leading to delays in the fulfillment of the Water Framework Directive objectives. Natural variability makes difficult to settle fixed reference values and boundary values for the Ecological Quality Ratios (EQR) for the biological quality elements. Biological responses to environmental degradation are frequently of nonmonotonic nature, hampering the EQR approach. Community structure traits respond only once ecological damage has already been done and do not provide early warning signals. An alternative methodology for the classification of ecological status integrating chemical measurements, ecotoxicological bioassays and community structure traits (species richness and diversity), and using multivariate analyses (multidimensional scaling and cluster analysis), is proposed. This approach does not depend on the arbitrary definition of fixed reference values and EQR boundary values, and it is suitable to integrate nonlinear, sensitive signals of ecological degradation. As a disadvantage, this approach demands the inclusion of sampling sites representing the full range of ecological status in each monitoring campaign. National or international agencies in charge of coastal pollution monitoring have comprehensive data sets available to overcome this limitation.

  18. Research on evaluation methods for water regulation ability of dams in the Huai River Basin

    Science.gov (United States)

    Shan, G. H.; Lv, S. F.; Ma, K.

    2016-08-01

    Water environment protection is a global and urgent problem that requires correct and precise evaluation. Evaluation methods have been studied for many years; however, there is a lack of research on the methods of assessing the water regulation ability of dams. Currently, evaluating the ability of dams has become a practical and significant research orientation because of the global water crisis, and the lack of effective ways to manage a dam's regulation ability has only compounded this. This paper firstly constructs seven evaluation factors and then develops two evaluation approaches to implement the factors according to the features of the problem. Dams of the Yin Shang ecological control section in the Huai He River basin are selected as an example to demonstrate the method. The results show that the evaluation approaches can produce better and more practical suggestions for dam managers.

  19. REDUCTION OF HERBICIDE AND WATER STRESS IN SPRING BARLEY BY REGULATORS OF POLYAMINE BIOSYNTHESIS

    Directory of Open Access Journals (Sweden)

    Pavol Trebichalský

    2014-02-01

    Full Text Available The experiment was carried out under artificial light of fluorescent lamps starting with 60 % full water capacity which was afterwards decreased on 40 % and finally the plants of barley were not watered. 30 plants of this cereal after plant emergence were thinned on 22 pieces. Experiment was treated by triazine herbicide, as well as its mixtures of regulators of polyamine synthesis: γ-aminobutyric acid, 1.3-propylenediamine dihydrochloride and salicyl acid. Solo application of triazine herbicide during water stress had negative balance on formation of root and above ground biomass. Addition of regulators of polyamine synthesis had positive effects on mentioned parameters, but not in comparison to control variant. These stress factors were eliminated most significantly only the application of GABA (100 g.ha-1 in mixture with herbicide.

  20. Local flow regulation and irrigation raise global human water consumption and footprint.

    Science.gov (United States)

    Jaramillo, Fernando; Destouni, Georgia

    2015-12-04

    Flow regulation and irrigation alter local freshwater conditions, but their global effects are highly uncertain. We investigated these global effects from 1901 to 2008, using hydroclimatic observations in 100 large hydrological basins. Globally, we find consistent and dominant effects of increasing relative evapotranspiration from both activities, and decreasing temporal runoff variability from flow regulation. The evapotranspiration effect increases the long-term average human consumption of fresh water by 3563 ± 979 km(3)/year from 1901-1954 to 1955-2008. This increase raises a recent estimate of the current global water footprint of humanity by around 18%, to 10,688 ± 979 km(3)/year. The results highlight the global impact of local water-use activities and call for their relevant account in Earth system modeling. Copyright © 2015, American Association for the Advancement of Science.

  1. Wdr18 is required for Kupffer's vesicle formation and regulation of body asymmetry in zebrafish.

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    Wei Gao

    Full Text Available Correct specification of the left-right (L-R axis is important for organ morphogenesis. Conserved mechanisms involving cilia rotation inside node-like structures and asymmetric Nodal signaling in the lateral plate mesoderm (LPM, which are important symmetry-breaking events, have been intensively studied. In zebrafish, the clustering and migration of dorsal forerunner cells (DFCs is critical for the formation of the Kuppfer's vesicle (KV. However, molecular events underlying DFC clustering and migration are less understood. The WD-repeat proteins function in a variety of biological processes, including cytoskeleton assembly, intracellular trafficking, mRNA splicing, transcriptional regulation and cell migration. However, little is known about the function of WD-repeat proteins in L-R asymmetry determination. Here, we report the identification and functional analyses of zebrafish wdr18, a novel gene that encodes a WD-repeat protein that is highly conserved among vertebrate species. wdr18 was identified from a Tol2 transposon-mediated enhancer trap screen. Follow-up analysis of wdr18 mRNA expression showed that it was detected in DFCs or the KV progenitor cells and later in the KV at early somitogenesis stages. Morpholino knockdown of wdr18 resulted in laterality defects in the visceral organs, which were preceded by the mis-expression of Nodal-related genes, including spaw and pitx2. Examination of morphants at earlier stages revealed that the KV had fewer and shorter cilia which are immotile and a smaller cavity. We further investigated the organization of DFCs in wdr18 morphant embryos using ntl and sox17 as specific markers and found that the clustering and migration of DFC was altered, leading to a disorganized KV. Finally, through a combination of wdr18 and itgb1b morpholino injections, we provided evidence that wdr18 and itgb1b genetically interact in the laterality determination process. Thus, we reveal a new and essential role for WD

  2. Experience of regulatory body functioning in energy industry of Ukraine: Prospects for future development of state regulation of energy

    International Nuclear Information System (INIS)

    Oruskaya, M.

    2002-01-01

    Materials collected (presented) in the paper introduce to (familiarise) the audience with the main forms, methods and phases of the state regulation of energy industry in Ukraine in the period of transition to market economy. Special attention was paid to the following aspects: 1. Necessity and history of establishment of special regulatory body in Ukraine - The National Electricity Regulatory Commission (NERC); 2. The main tasks and authorities of NERC according to the Ukraine Law on Energy Sector; 3. Regulation mechanisms of the main processes in the energy industry used by the Commission on the current level of energy sector development and economic results of its introduction; 4. Problems with functioning of the wholesale energy market specifically as the main component of the Ukraine energy industry and trends of future development (improvement of energy industry's financial situation, intensification of competition between energy producers and suppliers, improvement of tariff and investment policies, etc.); 5. Necessity and ways of future improvement of the standards and legal basis for regulation in Ukraine. (author)

  3. Role of algae in water quality regulation in NPP water reservoirs

    International Nuclear Information System (INIS)

    Klenus, V.G.; Kuz'menko, M.I.; Nasvit, O.I.

    1985-01-01

    Investigations, carried out in Chernobyl NPP water reservoir, show that sewage water inflow, being not sufficiently purified, enriched by mineral and organic substances, is accompanied by a considerable increase of algae productivity. The algae play a determining role in accumulation of radionuclides and their transformation into bottom depositions. Comparative investigation of accumulation intensity in alga cells 12 C and 14 C gives evidence that the rate of radioactive nuclide inclusions is practically adequate to the rate of inclusions of their stable analogues. Bacterial destruction of organic contaminations occurs more intensively under aerobic conditions, which are mainly provided due to photosynthetizing activity of algae

  4. Effect of increased intake of skimmed milk, casein, whey or water on body composition and leptin in overweight adolescents

    DEFF Research Database (Denmark)

    Larnkjær, Anni; Arnberg, Karina; Michaelsen, Kim F.

    2015-01-01

    BACKGROUNDS: Dairy proteins may support muscle protein synthesis and improve satiety in adults. However, there are limited studies using exact measures of body composition, especially in adolescents. OBJECTIVES: This study investigates the effect of milk proteins and water on body composition...... and leptin in overweight adolescents. METHODS: Subjects (n = 193) aged 12-15 years were randomized to drink 1 L d(-1) of skimmed milk, whey, casein (all milk-based drinks 35 g protein L(-1) ) or water for 12 weeks. Twenty participants dropped out. A pre-test control group of 32 adolescents was examined 12...... weeks before start of intervention. Outcomes included leptin and dual-energy X-ray absorptiometry scanning. The effects of the milk-based drinks on body composition and leptin were compared with baseline, pre-test control and water. RESULTS: Lean mass index (LMI) increased compared to baseline (all 95...

  5. Code of practice for the temporary diversion of water from hydrostatic testing of pipelines: Water Act - Water (Ministerial) Regulation No. 205

    International Nuclear Information System (INIS)

    1999-01-01

    A series of administrative procedures are described in this regulation regarding the temporary diversion of water for hydrostatic testing of pipelines in Alberta. These include the notification and timing of the release of water, where the test will occur and the possible effect of water release on the environment. The requirements of a hydrostatic test plan are described in point form. In accordance with the regulation, a person responsible for the testing must ensure that the testing does not cause a significant adverse effect on the aquatic environment or on any household user. Should this occur, all adverse effects on the aquatic environment should be fully mitigated. The reporting schedule and record keeping information are also covered. 2 tabs., 1 figs

  6. Adipose tissue (PRR regulates insulin sensitivity, fat mass and body weight

    Directory of Open Access Journals (Sweden)

    Zulaykho Shamansurova

    2016-10-01

    Full Text Available Objective: We previously demonstrated that the handle-region peptide, a prorenin/renin receptor [(PRR] blocker, reduces body weight and fat mass and may improve insulin sensitivity in high-fat fed mice. We hypothesized that knocking out the adipose tissue (PRR gene would prevent weight gain and insulin resistance. Methods: An adipose tissue-specific (PRR knockout (KO mouse was created by Cre-loxP technology using AP2-Cre recombinase mice. Because the (PRR gene is located on the X chromosome, hemizygous males were complete KO and had a more pronounced phenotype on a normal diet (ND diet compared to heterozygous KO females. Therefore, we challenged the female mice with a high-fat diet (HFD to uncover certain phenotypes. Mice were maintained on either diet for 9 weeks. Results: KO mice had lower body weights compared to wild-types (WT. Only hemizygous male KO mice presented with lower total fat mass, higher total lean mass as well as smaller adipocytes compared to WT mice. Although food intake was similar between genotypes, locomotor activity during the active period was increased in both male and female KO mice. Interestingly, only male KO mice had increased O2 consumption and CO2 production during the entire 24-hour period, suggesting an increased basal metabolic rate. Although glycemia during a glucose tolerance test was similar, KO males as well as HFD-fed females had lower plasma insulin and C-peptide levels compared to WT mice, suggesting improved insulin sensitivity. Remarkably, all KO animals exhibited higher circulating adiponectin levels, suggesting that this phenotype can occur even in the absence of a significant reduction in adipose tissue weight, as observed in females and, thus, may be a specific effect related to the (PRR. Conclusions: (PRR may be an important therapeutic target for the treatment of obesity and its associated complications such as type 2 diabetes. Keywords: (Prorenin receptor, Renin-angiotensin system, Adipose

  7. Visfatin Triggers Anorexia and Body Weight Loss through Regulating the Inflammatory Response in the Hypothalamic Microglia

    Directory of Open Access Journals (Sweden)

    Thai Hien Tu

    2017-01-01

    Full Text Available Visfatin is an adipokine that is secreted from adipose tissue, and it is involved in a variety of physiological processes. In particular, visfatin has been implicated in metabolic diseases, such as obesity and type 2 diabetes, which are directly linked to systemic inflammation. However, the potential impacts of visfatin on the hypothalamic control of energy homeostasis, which is involved in microglial inflammation, have not fully been investigated. In this study, we found that treatment with exogenous recombinant visfatin protein led to the activation of the inflammatory response in a microglial cell line. In addition, we observed that central administration of visfatin led to the activation of microglia in the hypothalamus. Finally, we found that visfatin reduced food intake and body weight through activating POMC neurons in association with microglia activation in mice. These findings indicate that elevation of central visfatin levels may be associated with homeostatic feeding behavior in response to metabolic shifts, such as increased adiposity following inflammatory processes in the hypothalamus.

  8. Counterregulation of insulin by leptin as key component of autonomic regulation of body weight

    Science.gov (United States)

    Borer, Katarina T

    2014-01-01

    A re-examination of the mechanism controlling eating, locomotion, and metabolism prompts formulation of a new explanatory model containing five features: a coordinating joint role of the (1) autonomic nervous system (ANS); (2) the suprachiasmatic (SCN) master clock in counterbalancing parasympathetic digestive and absorptive functions and feeding with sympathetic locomotor and thermogenic energy expenditure within a circadian framework; (3) interaction of the ANS/SCN command with brain substrates of reward encompassing dopaminergic projections to ventral striatum and limbic and cortical forebrain. These drive the nonhomeostatic feeding and locomotor motivated behaviors in interaction with circulating ghrelin and lateral hypothalamic neurons signaling through melanin concentrating hormone and orexin-hypocretin peptides; (4) counterregulation of insulin by leptin of both gastric and adipose tissue origin through: potentiation by leptin of cholecystokinin-mediated satiation, inhibition of insulin secretion, suppression of insulin lipogenesis by leptin lipolysis, and modulation of peripheral tissue and brain sensitivity to insulin action. Thus weight-loss induced hypoleptimia raises insulin sensitivity and promotes its parasympathetic anabolic actions while obesity-induced hyperleptinemia supresses insulin lipogenic action; and (5) inhibition by leptin of bone mineral accrual suggesting that leptin may contribute to the maintenance of stability of skeletal, lean-body, as well as adipose tissue masses. PMID:25317239

  9. The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions.

    Science.gov (United States)

    Gambarte Tudela, Julian; Capmany, Anahi; Romao, Maryse; Quintero, Cristian; Miserey-Lenkei, Stephanie; Raposo, Graca; Goud, Bruno; Damiani, Maria Teresa

    2015-08-15

    Given their obligate intracellular lifestyle, Chlamydia trachomatis ensure that they have access to multiple host sources of essential lipids by interfering with vesicular transport. These bacteria hijack Rab6-, Rab11- and Rab14-controlled trafficking pathways to acquire sphingomyelin from the Golgi complex. Another important source of sphingolipids, phospholipids and cholesterol are multivesicular bodies (MVBs). Despite their participation in chlamydial inclusion development and bacterial replication, the molecular mechanisms mediating the interaction between MVBs and chlamydial inclusions remain unknown. In the present study, we demonstrate that Rab39a labels a subset of late endocytic vesicles - mainly MVBs - that move along microtubules. Moreover, Rab39a is actively recruited to chlamydial inclusions throughout the pathogen life cycle by a bacterial-driven process that depends on the Rab39a GTP- or GDP-binding state. Interestingly, Rab39a participates in the delivery of MVBs and host sphingolipids to maturing chlamydial inclusions, thereby promoting inclusion growth and bacterial development. Taken together, our findings indicate that Rab39a favours chlamydial replication and infectivity. This is the first report showing that a late endocytic Rab GTPase is involved in chlamydial infection development. © 2015. Published by The Company of Biologists Ltd.

  10. Specialist-generalist model of body temperature regulation can be applied at the intraspecific level.

    Science.gov (United States)

    Przybylska, Anna S; Boratyński, Jan S; Wojciechowski, Michał S; Jefimow, Małgorzata

    2017-07-01

    According to theoretical predictions, endothermic homeotherms can be classified as either thermal specialists or thermal generalists. In high cost environments, thermal specialists are supposed to be more prone to using facultative heterothermy than generalists. We tested this hypothesis at the intraspecific level using male laboratory mice (C57BL/cmdb) fasted under different thermal conditions (20 and 10°C) and for different time periods (12-48 h). We predicted that variability of body temperature ( T b ) and time spent with T b below normothermy would increase with the increase of environmental demands (duration of fasting and cold). To verify the above prediction, we measured T b and energy expenditure of fasted mice. We did not record torpor bouts but we found that variations in T b and time spent in hypothermia increased with environmental demands. In response to fasting, mice also decreased their energy expenditure. Moreover, animals that showed more precise thermoregulation when fed had more variable T b when fasted. We postulate that the prediction of the thermoregulatory generalist-specialist trade-off can be applied at the intraspecific level, offering a valid tool for identifying mechanistic explanations of the differences in animal responses to variations in energy supply. © 2017. Published by The Company of Biologists Ltd.

  11. Urea, creatinine, uric acid, and phosphate spaces and their relationship to total body water during chronic hemodialysis

    International Nuclear Information System (INIS)

    Ericsson, F.; Odar-Cederloef, I.E.; Eriksson, C.G.; Lindgren, S.; Kjellstrand, C.M.

    1988-01-01

    The authors determined total body water (TBW) with tritium in 11 patients on chronic hemodialysis and compared this space to that estimated by 60% of body weight, and removal spaces of urea, creatinine, uric acid, and phosphate (PO 4 ). The latter spaces were determined by dividing the total amount of substance (measured in total dialysate) by pre- minus post-dialysis concentrations. Body water X 0.6 was more than 10% less than the tritium space, and showed a maximal variation of 10 liters, or 24%. The removal space of urea was 80% of the tritium space, but correlated closely with it. The difference between total body water and urea removal space was variable and dependent on fluid excess (edema) in the patients. Creatinine, uric acid, and phosphate removal spaces were highly variable and not correlated to total body water. The authors suggest that actual measured TBW should be used, rather than estimations using BW X 0.6, for V in K X T/V, where K = clearance, T = duration of dialysis, and V = the removal space of urea. Furthermore, one may need to introduce a correction factor for urea removal space over TBW in the equation to allow better quantification of dialysis in edematous patients and during very fast dialyses

  12. IL-8 signaling is up-regulated in alcoholic hepatitis and DDC fed mice with Mallory Denk Bodies (MDBs) present.

    Science.gov (United States)

    Liu, Hui; French, Barbara A; Nelson, Tyler J; Li, Jun; Tillman, Brittany; French, Samuel W

    2015-10-01

    Chemokines and their receptors are involved in oncogenesis and in tumor progression, invasion, and metastasis. Various chemokines also promote cell proliferation and resistance to apoptosis of stressed cells. The chemokine CXCL8, also known as interleukin-8 (IL-8), is a proinflammatory molecule that has functions within the tumor microenvironment. Deregulation of IL-8 signaling is shown to play pivotal roles in tumorigenesis and progression. Mallory-Denk Bodies (MDBs) are prevalent in various liver diseases including alcoholic hepatitis (AH) and are formed in mice livers by feeding DDC. By comparing AH livers where MDBs had formed with normal livers, there were significant changes of IL-8 signaling by RNA sequencing (RNA-Seq) analyses. Real-time PCR analysis of CXCR2 further shows a 6-fold up-regulation in AH livers and a 26-fold up-regulation in the livers of DDC re-fed mice. IL-8 mRNA was also significantly up-regulated in AH livers and DDC re-fed mice livers. This indicates that CXCR2 and IL-8 may be crucial for liver MDB formation. MDB containing balloon hepatocytes in AH livers had increased intensity of staining of the cytoplasm for both CXCR2 and IL-8. Overexpression of IL-8 leads to an increase of the mitogen activated protein kinase (MAPK) cascade and exacerbates the inflammatory cycle. These observations constitute a demonstration of the altered regulation of IL-8 signaling in the livers of AH and mice fed DDC where MDBs formed, providing further insight into the mechanism of MDB formation mediated by IL-8 signaling in AH. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. Lake and wetland ecosystem services measuring water storage and local climate regulation

    Science.gov (United States)

    Wong, Christina P.; Jiang, Bo; Bohn, Theodore J.; Lee, Kai N.; Lettenmaier, Dennis P.; Ma, Dongchun; Ouyang, Zhiyun

    2017-04-01

    Developing interdisciplinary methods to measure ecosystem services is a scientific priority, however, progress remains slow in part because we lack ecological production functions (EPFs) to quantitatively link ecohydrological processes to human benefits. In this study, we tested a new approach, combining a process-based model with regression models, to create EPFs to evaluate water storage and local climate regulation from a green infrastructure project on the Yongding River in Beijing, China. Seven artificial lakes and wetlands were established to improve local water storage and human comfort; evapotranspiration (ET) regulates both services. Managers want to minimize the trade-off between water losses and cooling to sustain water supplies while lowering the heat index (HI) to improve human comfort. We selected human benefit indicators using water storage targets and Beijing's HI, and the Variable Infiltration Capacity model to determine the change in ET from the new ecosystems. We created EPFs to quantify the ecosystem services as marginal values [Δfinal ecosystem service/Δecohydrological process]: (1) Δwater loss (lake evaporation/volume)/Δdepth and (2) Δsummer HI/ΔET. We estimate the new ecosystems increased local ET by 0.7 mm/d (20.3 W/m2) on the Yongding River. However, ET rates are causing water storage shortfalls while producing no improvements in human comfort. The shallow lakes/wetlands are vulnerable to drying when inflow rates fluctuate, low depths lead to higher evaporative losses, causing water storage shortfalls with minimal cooling effects. We recommend managers make the lakes deeper to increase water storage, and plant shade trees to improve human comfort in the parks.

  14. Dissection of Molecular Mechanisms Regulating Protein Body Formation in Maize Endosperm - DE-FG03-95-ER20183

    International Nuclear Information System (INIS)

    Larkins, Brian A.

    2003-01-01

    Dissection of Molecular Mechanisms Regulating Protein Body Formation in Maize Endosperm - DE-FG03-95-ER20183 Final Technical Report and Patent Summary Dr. Brian A. Larkins, Department of Plant Sciences, University of Arizona, Tucson, AZ 85721 Endosperm texture is an important quality trait in maize, as it influences the shipping characteristics of the grain, its susceptibility to insects, the yield of grits from dry milling, energy costs during wet milling, and the baking and digestibility properties of the flour. There appears to be a causal relationship between kernel hardness and the formation of zein-containing protein bodies, as mutations affecting protein body number and structure are associated with a soft, starchy kernel. In this project we used a variety of approaches to better understand this relationship and investigate the molecular and biochemical changes associated with starchy endosperm mutants. We characterized the distribution of zein mRNAs on endosperm rough endoplasmic reticulum (RER) membranes and the interactions between zein proteins, as each of these could influence the structure of protein bodies. Based on in situ hybridization, mRNAs encoding the 22-kD alpha- and 27-kD gamma-zeins are randomly distributed on RER; hence, mRNA targeting does not appear to influence the formation of protein bodies. Investigation of the interactions between zein proteins (alpha, beta, gamma, delta) with the yeast two-hybrid system showed that interactions between the 19- and 22-alpha-zeins are relatively weak, although each of them interacted strongly with the 10-kD delta-zein. Strong interactions were detected between the alpha- and delta-zeins and the 16-kD gamma- and 15-kD beta-zeins; however, the 50-kD and 27-kD gamma-zeins did not interact detectably with the alpha- and delta-zein proteins. The NH2- and COOH-terminal domains of the 22-kD alpha-zein were found to interact most strongly with the 15-kD beta- and 16-kD gamma-zeins, suggesting the 16-kD and 15

  15. Comparison of permutationally invariant polynomials, neural networks, and Gaussian approximation potentials in representing water interactions through many-body expansions

    Science.gov (United States)

    Nguyen, Thuong T.; Székely, Eszter; Imbalzano, Giulio; Behler, Jörg; Csányi, Gábor; Ceriotti, Michele; Götz, Andreas W.; Paesani, Francesco

    2018-06-01

    The accurate representation of multidimensional potential energy surfaces is a necessary requirement for realistic computer simulations of molecular systems. The continued increase in computer power accompanied by advances in correlated electronic structure methods nowadays enables routine calculations of accurate interaction energies for small systems, which can then be used as references for the development of analytical potential energy functions (PEFs) rigorously derived from many-body (MB) expansions. Building on the accuracy of the MB-pol many-body PEF, we investigate here the performance of permutationally invariant polynomials (PIPs), neural networks, and Gaussian approximation potentials (GAPs) in representing water two-body and three-body interaction energies, denoting the resulting potentials PIP-MB-pol, Behler-Parrinello neural network-MB-pol, and GAP-MB-pol, respectively. Our analysis shows that all three analytical representations exhibit similar levels of accuracy in reproducing both two-body and three-body reference data as well as interaction energies of small water clusters obtained from calculations carried out at the coupled cluster level of theory, the current gold standard for chemical accuracy. These results demonstrate the synergy between interatomic potentials formulated in terms of a many-body expansion, such as MB-pol, that are physically sound and transferable, and machine-learning techniques that provide a flexible framework to approximate the short-range interaction energy terms.

  16. PAT Design Strategy for Energy Recovery in Water Distribution Networks by Electrical Regulation

    Directory of Open Access Journals (Sweden)

    Helena M. Ramos

    2013-01-01

    Full Text Available In the management of water distribution networks, large energy savings can be yielded by exploiting the head drop due to the network pressure control strategy, i.e., for leak reductions. Hydropower in small streams is already exploited, but technical solutions combining efficiency and economic convenience are still required. In water distribution networks, an additional design problem comes out from the necessity of ensuring a required head drop under variable operating conditions, i.e., head and discharge variations. Both a hydraulic regulation (HR—via a series-parallel hydraulic circuit- and an electrical regulation (ER—via inverter- are feasible solutions. A design procedure for the selection of a production device in a series-parallel hydraulic circuit has been recently proposed. The procedure, named VOS (Variable Operating Strategy, is based on the overall plant efficiency criteria and is applied to a water distribution network where a PAT (pump as a turbine is used in order to produce energy. In the present paper the VOS design procedure has been extended to the electrical regulation and a comparison between HR and ER efficiency and flexibility within a water distribution network is shown: HR was found more flexible than ER and more efficient. Finally a preliminary economic study has been carried out in order to show the viability of both systems, and a shorter payback period of the electromechanical equipment was found for HR mode.

  17. The Relationship Between Symptoms of Eating Disorders and Worry About Body Image, Attachment Styles, and Cognitive Emotion Regulation Strategies Among Students of Ahvaz Jundishapur University of Medical Sciences

    Directory of Open Access Journals (Sweden)

    Davodi

    2016-02-01

    Full Text Available Background There are different assumptions about the factors responsible for the genesis and maintenance of eating disorders. Each of the two main types of eating disorders results from a complex interaction of emotional and psychological factors. Objectives The purpose of the current research was to study the relationship between symptoms of eating disorders and worry about body image, attachment styles, and cognitive emotion regulation strategies, among a sample of students at Ahvaz Jundishapur University. Materials and Methods The study sample consisted of students of Ahvaz Jundishapur University of Medical Sciences, 2011 - 2012. The research participants were selected with use of multistage random sample from various colleges. Our research tools were the eating attitudes questionnaire (EAT-26, the Worry about body image questionnaire, the attachment styles questionnaire, and a questionnaire on cognitive emotion regulation strategies. Pearson correlation and stepwise regression methods, with inter and stepwise methods, were used during data analysis. Results The results of this research indicated that worry about body image, an avoidant attachment style, negative cognitive emotion regulation strategies, and secure attachment style in regression equation remained significant (P < 0.0001. Results also showed that worry about body image, an anxious attachment style, an avoidant attachment style, and negative cognitive emotion regulation strategies were significant in the regression equation, predicting 19% of the variance in the eating disorder symptoms. Conclusions Concerns about body image, an avoidant attachment style, and cognitive strategies to regulate negative emotions were the strongest predictors for eating disorder symptoms. Based on current research findings, an avoidance attachment style, concerns about body image, and negative emotion regulation cognitive strategies increase eating disorder symptoms in students. Because attachment

  18. Genomic profiling of neutrophil transcripts in Asian Qigong practitioners: a pilot study in gene regulation by mind-body interaction.

    Science.gov (United States)

    Li, Quan-Zhen; Li, Ping; Garcia, Gabriela E; Johnson, Richard J; Feng, Lili

    2005-02-01

    The great similarity of the genomes of humans and other species stimulated us to search for genes regulated by elements associated with human uniqueness, such as the mind-body interaction. DNA microarray technology offers the advantage of analyzing thousands of genes simultaneously, with the potential to determine healthy phenotypic changes in gene expression. The aim of this study was to determine the genomic profile and function of neutrophils in Falun Gong (FLG, an ancient Chinese Qigong) practitioners, with healthy subjects as controls. Six (6) Asian FLG practitioners and 6 Asian normal healthy controls were recruited for our study. The practitioners have practiced FLG for at least 1 year (range, 1-5 years). The practice includes daily reading of FLG books and daily practice of exercises lasting 1-2 hours. Selected normal healthy controls did not perform Qigong, yoga, t'ai chi, or any other type of mind-body practice, and had not followed any conventional physical exercise program for at least 1 year. Neutrophils were isolated from fresh blood and assayed for gene expression, using microarrays and RNase protection assay (RPA), as well as for function (phagocytosis) and survival (apoptosis). The changes in gene expression of FLG practitioners in contrast to normal healthy controls were characterized by enhanced immunity, downregulation of cellular metabolism, and alteration of apoptotic genes in favor of a rapid resolution of inflammation. The lifespan of normal neutrophils was prolonged, while the inflammatory neutrophils displayed accelerated cell death in FLG practitioners as determined by enzyme-linked immunosorbent assay. Correlating with enhanced immunity reflected by microarray data, neutrophil phagocytosis was significantly increased in Qigong practitioners. Some of the altered genes observed by microarray were confirmed by RPA. Qigong practice may regulate immunity, metabolic rate, and cell death, possibly at the transcriptional level. Our pilot study

  19. Canine body composition quantification using 3 tesla fat-water MRI.

    Science.gov (United States)

    Gifford, Aliya; Kullberg, Joel; Berglund, Johan; Malmberg, Filip; Coate, Katie C; Williams, Phillip E; Cherrington, Alan D; Avison, Malcolm J; Welch, E Brian

    2014-02-01

    To test the hypothesis that a whole-body fat-water MRI (FWMRI) protocol acquired at 3 Tesla combined with semi-automated image analysis techniques enables precise volume and mass quantification of adipose, lean, and bone tissue depots that agree with static scale mass and scale mass changes in the context of a longitudinal study of large-breed dogs placed on an obesogenic high-fat, high-fructose diet. Six healthy adult male dogs were scanned twice, at weeks 0 (baseline) and 4, of the dietary regiment. FWMRI-derived volumes of adipose tissue (total, visceral, and subcutaneous), lean tissue, and cortical bone were quantified using a semi-automated approach. Volumes were converted to masses using published tissue densities. FWMRI-derived total mass corresponds with scale mass with a concordance correlation coefficient of 0.931 (95% confidence interval = [0.813, 0.975]), and slope and intercept values of 1.12 and -2.23 kg, respectively. Visceral, subcutaneous and total adipose tissue masses increased significantly from weeks 0 to 4, while neither cortical bone nor lean tissue masses changed significantly. This is evidenced by a mean percent change of 70.2% for visceral, 67.0% for subcutaneous, and 67.1% for total adipose tissue. FWMRI can precisely quantify and map body composition with respect to adipose, lean, and bone tissue depots. The described approach provides a valuable tool to examine the role of distinct tissue depots in an established animal model of human metabolic disease. Copyright © 2013 Wiley Periodicals, Inc.

  20. 33 CFR 165.1313 - Security zone regulations, tank ship protection, Puget Sound and adjacent waters, Washington

    Science.gov (United States)

    2010-07-01

    ... Areas Thirteenth Coast Guard District § 165.1313 Security zone regulations, tank ship protection, Puget... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security zone regulations, tank ship protection, Puget Sound and adjacent waters, Washington 165.1313 Section 165.1313 Navigation and...

  1. 77 FR 23120 - Special Local Regulations; Lowcountry Splash Open Water Swim, Wando River and Cooper River, Mount...

    Science.gov (United States)

    2012-04-18

    ...-AA08 Special Local Regulations; Lowcountry Splash Open Water Swim, Wando River and Cooper River, Mount... establishing special local regulations on the waters of the Wando River and Cooper River in Mount Pleasant... River and Cooper River along the shoreline of Mount Pleasant, South Carolina. The Lowcountry Splash...

  2. Ambition, Regulation and Reality. Complex use of land and water resources in Luwu, South Sulawesi, Indonesia

    OpenAIRE

    Roth, D.

    2003-01-01

    In this book I present three case studies of the complex regulation of use of land and water resources in Luwu. Attention to the role of legalcomplexity -the existence of different sources and definitions of normative-legal regulation in the same socio-political space - is an important conceptual point of departure of this study. Each of the three case study sections contains specific conclusions pertaining to the issues involved. The last chapter of the book (chapter 11) is primarily a refle...

  3. The Hydraulic Mission and the Mexican Hydrocracy: Regulating and Reforming the Flows of Water and Power

    Directory of Open Access Journals (Sweden)

    Philippus Wester

    2009-10-01

    Full Text Available In Mexico, the hydraulic mission, the centralisation of water control, and the growth of the federal hydraulic bureaucracy (hydrocracy recursively shaped and reinforced each other during the 20th century. The hydraulic mission entails that the state, embodied in an autonomous hydrocracy, takes the lead in water resources development to capture as much water as possible for human uses. The hydraulic mission was central to the formation of Mexico’s hydrocracy, which highly prized its autonomy. Bureaucratic rivals, political transitions, and economic developments recurrently challenged the hydrocracy’s degree of autonomy. However, driven by the argument that a single water authority should regulate and control the nation’s waters, the hydrocracy consistently managed to renew its, always precarious, autonomy at different political moments in the country’s history. The legacy of the hydraulic mission continues to inform water reforms in Mexico, and largely explains the strong resilience of the Mexican hydrocracy to 'deep' institutional change and political transitions. While the emphasis on infrastructure has lessened, the hydrocracy has actively renewed its control over water decisions and budgets and has played a remarkably constant, hegemonic role in defining and shaping Mexico’s water laws, policies and institutions.

  4. Automated Recognition of Vegetation and Water Bodies on the Territory of Megacities in Satellite Images of Visible and IR Bands

    Science.gov (United States)

    Mozgovoy, Dmitry k.; Hnatushenko, Volodymyr V.; Vasyliev, Volodymyr V.

    2018-04-01

    Vegetation and water bodies are a fundamental element of urban ecosystems, and water mapping is critical for urban and landscape planning and management. A methodology of automated recognition of vegetation and water bodies on the territory of megacities in satellite images of sub-meter spatial resolution of the visible and IR bands is proposed. By processing multispectral images from the satellite SuperView-1A, vector layers of recognized plant and water objects were obtained. Analysis of the results of image processing showed a sufficiently high accuracy of the delineation of the boundaries of recognized objects and a good separation of classes. The developed methodology provides a significant increase of the efficiency and reliability of updating maps of large cities while reducing financial costs. Due to the high degree of automation, the proposed methodology can be implemented in the form of a geo-information web service functioning in the interests of a wide range of public services and commercial institutions.

  5. The use of bioelectrical impedance analysis to estimate total body water in young children with cerebral palsy.

    Science.gov (United States)

    Bell, Kristie L; Boyd, Roslyn N; Walker, Jacqueline L; Stevenson, Richard D; Davies, Peter S W

    2013-08-01

    Body composition assessment is an essential component of nutritional evaluation in children with cerebral palsy. This study aimed to validate bioelectrical impedance to estimate total body water in young children with cerebral palsy and determine best electrode placement in unilateral impairment. 55 young children with cerebral palsy across all functional ability levels were included. Height/length was measured or estimated from knee height. Total body water was estimated using a Bodystat 1500MDD and three equations, and measured using the gold standard, deuterium dilution technique. Comparisons were made using Bland Altman analysis. For children with bilateral impairment, the Fjeld equation estimated total body water with the least bias (limits of agreement): 0.0 L (-1.4 L to 1.5 L); the Pencharz equation produced the greatest: 2.7 L (0.6 L-4.8 L). For children with unilateral impairment, differences between measured and estimated total body water were lowest on the unimpaired side using the Fjeld equation 0.1 L (-1.5 L to 1.6 L)) and greatest for the Pencharz equation. The ability of bioelectrical impedance to estimate total body water depends on the equation chosen. The Fjeld equation was the most accurate for the group, however, individual results varied by up to 18%. A population specific equation was developed and may enhance the accuracy of estimates. Australian New Zealand Clinical Trials Registry (ANZCTR) number: ACTRN12611000616976. Copyright © 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  6. Carbon sequestration and water flow regulation services in mature Mediterranean Forest

    Science.gov (United States)

    Beguería, S.; Ovando, P.

    2015-12-01

    We develop a forestland use and management model that integrates spatially-explicit biophysical and economic data, to estimate the expected pattern of climate regulation services through carbon dioxide (CO2) sequestration in tree and shrubs biomass, and water flow regulation. We apply this model to examine the potential trade-offs and synergies in the supply of CO2 sequestration and water flow services in mature Mediterranean forest, considering two alternative forest management settings. A forest restoration scenario through investments in facilitating forest regeneration, and a forestry activity abandonment scenario as result of unprofitable forest regeneration investment. The analysis is performed for different discount rates and price settings for carbon and water. The model is applied at the farm level in a group of 567 private silvopastoral farms across Andalusia (Spain), considering the main forest species in this region: Quercus ilex, Q. suber, Pinus pinea, P. halepensis, P. pinaster and Eucalyptus sp., as well as for tree-less shrubland and pastures. The results of this research are provided by forest land unit, vegetation, farm and for the group of municipalities where the farms are located. Our results draw attention to the spatial variability of CO2 and water flow regulation services, and point towards a trade-off between those services. The pattern of economic benefits associated to water and carbon services fluctuates according to the assumptions regarding price levels and discounting rates, as well as in connection to the expected forest management and tree growth models, and to spatially-explicit forest attributes such as existing tree and shrubs inventories, the quality of the sites for growing different tree species, soil structure or the climatic characteristics. The assumptions made regarding the inter-temporal preferences and relative prices have a large effect on the estimated economic value of carbon and water services. These results

  7. The polyketide synthase gene pks4 is essential for sexual development and regulates fruiting body morphology in Sordaria macrospora.

    Science.gov (United States)

    Schindler, Daniel; Nowrousian, Minou

    2014-07-01

    Filamentous ascomycetes have long been known as producers of a variety of secondary metabolites, many of which have toxic effects on other organisms. However, the role of these metabolites in the biology of the fungi that produce them remains in most cases enigmatic. A major group of fungal secondary metabolites are polyketides. They are chemically diverse, but have in common that their chemical scaffolds are synthesized by polyketide synthases (PKSs). In a previous study, we analyzed development-dependent expression of pks genes in the filamentous ascomycete Sordaria macrospora. Here, we show that a deletion mutant of the pks4 gene is sterile, producing only protoperithecia but no mature perithecia, whereas overexpression of pks4 leads to enlarged, malformed fruiting bodies. Thus, correct expression levels of pks4 are essential for wild type-like perithecia formation. The predicted PKS4 protein has a domain structure that is similar to homologs in other fungi, but conserved residues of a methyl transferase domain present in other fungi are mutated in PKS4. Expression of several developmental genes is misregulated in the pks4 mutant. Surprisingly, the development-associated app gene is not downregulated in the mutant, in contrast to all other previously studied mutants with a block at the protoperithecial stage. Our data show that the polyketide synthase gene pks4 is essential for sexual development and plays a role in regulating fruiting body morphology. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.

    Science.gov (United States)

    Chen, Jun; Joshi, Shailen K; DiDomenico, Stanley; Perner, Richard J; Mikusa, Joe P; Gauvin, Donna M; Segreti, Jason A; Han, Ping; Zhang, Xu-Feng; Niforatos, Wende; Bianchi, Bruce R; Baker, Scott J; Zhong, Chengmin; Simler, Gricelda H; McDonald, Heath A; Schmidt, Robert G; McGaraughty, Steve P; Chu, Katharine L; Faltynek, Connie R; Kort, Michael E; Reilly, Regina M; Kym, Philip R

    2011-05-01

    Despite the increasing interest in TRPA1 channel as a pain target, its role in cold sensation and body temperature regulation is not clear; the efficacy and particularly side effects resulting from channel blockade remain poorly understood. Here we use a potent, selective, and bioavailable antagonist to address these issues. A-967079 potently blocks human (IC(50): 51 nmol/L, electrophysiology, 67 nmol/L, Ca(2+) assay) and rat TRPA1 (IC(50): 101 nmol/L, electrophysiology, 289 nmol/L, Ca(2+) assay). It is >1000-fold selective over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes, and G-protein-coupled receptors. Oral dosing of A-967079 produces robust drug exposure in rodents, and exhibits analgesic efficacy in allyl isothiocyanate-induced nocifensive response and osteoarthritic pain in rats (ED(50): 23.2 mg/kg, p.o.). A-967079 attenuates cold allodynia produced by nerve injury but does not alter noxious cold sensation in naive animals, suggesting distinct roles of TRPA1 in physiological and pathological states. Unlike TRPV1 antagonists, A-967079 does not alter body temperature. It also does not produce locomotor or cardiovascular side effects. Collectively, these data provide novel insights into TRPA1 function and suggest that the selective TRPA1 blockade may present a viable strategy for alleviating pain without untoward side effects. Copyright © 2011 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  9. Sources of variation in estimates of lean body mass by creatinine kinetics and by methods based on body water or body mass index in patients on continuous peritoneal dialysis.

    Science.gov (United States)

    Tzamaloukas, Antonios H; Murata, Glen H; Piraino, Beth; Raj, Dominic S C; VanderJagt, Dorothy J; Bernardini, Judith; Servilla, Karen S; Sun, Yijuan; Glew, Robert H; Oreopoulos, Dimitrios G

    2010-03-01

    We identified factors that account for differences between lean body mass computed from creatinine kinetics (LBM(cr)) and from either body water (LBM(V)) or body mass index (LBM(BMI)) in patients on continuous peritoneal dialysis (CPD). We compared the LBM(cr) and LBM(V) or LBM(BMI) in hypothetical subjects and actual CPD patients. We studied 439 CPD patients in Albuquerque, Pittsburgh, and Toronto, with 925 clearance studies. Creatinine production was estimated using formulas derived in CPD patients. Body water (V) was estimated from anthropometric formulas. We calculated LBM(BMI) from a formula that estimates body composition based on body mass index. In hypothetical subjects, LBM values were calculated by varying the determinants of body composition (gender, diabetic status, age, weight, and height) one at a time, while the other determinants were kept constant. In actual CPD patients, multiple linear regression and logistic regression were used to identify factors associated with differences in the estimates of LBM (LBM(cr)LBM(V), or LBM(cr)LBM(BMI)). We sought predictors of the differences LBM(V) - LBM(cr) and LBM(BMI) - LBM(cr). Both LBM(V) (regardless of formula used to estimate V) and LBM(BMI) exceeded LBM(cr) in hypothetical subjects with average body compositions. The sources of differences between LBM estimates in this group involved differences in the coefficients assigned to gender, age, height, weight, presence or absence of diabetes, and serum creatinine concentration. In CPD patients, mean LBM(V) or LBM(BMI) exceeded mean LBM(cr) by 6.2 to 6.9 kg. For example, the LBM(V) obtained from one anthropometric formula was 50.4+/-10.4 kg and the LBM(cr) was 44.1+/-13.6 kg (P LBM(cr)>LBM(V). The differences in determinants of body composition between groups with high versus low LBM(cr) were similar in hypothetical and actual CPD patients. Multivariate analysis in actual CPD patients identified serum creatinine, height, age, gender, weight, and body mass

  10. THERMAL CONDUCTANCE IN AQUATIC BIRDS IN RELATION TO THE DEGREE OF WATER CONTACT, BODY-MASS, AND BODY-FAT - ENERGETIC IMPLICATIONS OF LIVING IN A STRONG COOLING ENVIRONMENT

    NARCIS (Netherlands)

    DEVRIES, J; VANEERDEN, MR

    1995-01-01

    Thermal conductance of carcasses of 14 aquatic bird species was determined by the warming constant technique. The effect on thermal conductance of body mass, age sex, fat deposits, and the degree of contact with water were studied. Only body mass and the degree of submergence in water had an effect.

  11. An experimental study on the excitation of large volume airguns in a small volume body of water

    International Nuclear Information System (INIS)

    Wang, Baoshan; Yang, Wei; Yuan, Songyong; Ge, Hongkui; Chen, Yong; Guo, Shijun; Xu, Ping

    2010-01-01

    A large volume airgun array is effective in generating seismic waves, which is extensively used in large volume bodies of water such as oceans, lakes and reservoirs. So far, the application of large volume airguns is subject to the distribution of large volume bodies of water. This paper reports an attempt to utilize large volume airguns in a small body of water as a seismic source for seismotectonic studies. We carried out a field experiment in Mapaoquan pond, Fangshan district, Beijing, during the period 25–30 May 2009. Bolt LL1500 airguns, each with volumes of 2000 in 3 , the largest commercial airguns available today, were used in this experiment. We tested the excitation of the airgun array with one or two guns. The airgun array was placed 7–11 m below the water's surface. The near- and far-field seismic motions induced by the airgun source were recorded by a 100 km long seismic profile composed of 16 portable seismometers and a 100 m long strong motion seismograph profile, respectively. The following conclusions can be drawn from this experiment. First, it is feasible to excite large volume airguns in a small volume body of water. Second, seismic signals from a single shot of one airgun can be recognized at the offset up to 15 km. Taking advantage of high source repeatability, we stacked records from 128 shots to enhance the signal-to-noise ratio, and direct P-waves can be easily identified at the offset ∼50 km in stacked records. Third, no detectable damage to fish or near-field constructions was caused by the airgun shots. Those results suggest that large volume airguns excited in small bodies of water can be used as a routinely operated seismic source for mid-scale (tens of kilometres) subsurface explorations and monitoring under various running conditions

  12. The tracer function of isotope composition and deuterium excess parameter of water bodies on prospecting for geothermal water: taking the prospecting for geothermal water in Sanjianshui, Sichuan for example

    International Nuclear Information System (INIS)

    Yang Bo; Yin Guan

    2003-01-01

    Based on the isotope composition features of water bodies in Sanjiashui area, this paper use the theory of deuterium excess parameter (d) to discuss and cause of formulation, recharge source, removed patch, detained time and dynamics feature on ground water. These discussed problems have far-reaching meaning on evaluating the size of geothermal water, exploited potential of thermal spring and find new thermal spring in neighboring area. We analyze the relation of d and tritium content (T) on different water bodies in Sanjianshui area and draw some conclusions. Firstly, all water bodies in Sanjianshui origin from precipitation. Secondly, precipitation of northwest mountain area that have long removed patch and long detained time is the recharge resource of groundwater in basin. In addition, we demonstrate the possibility of existence of geothermal water in several positions of Sanjianshui area. (authors)

  13. Revisiting a many-body model for water based on a single polarizable site: from gas phase clusters to liquid and air/liquid water systems.

    Science.gov (United States)

    Réal, Florent; Vallet, Valérie; Flament, Jean-Pierre; Masella, Michel

    2013-09-21

    We present a revised version of the water many-body model TCPE [M. Masella and J.-P. Flament, J. Chem. Phys. 107, 9105 (1997)], which is based on a static three charge sites and a single polarizable site to model the molecular electrostatic properties of water, and on an anisotropic short range many-body energy term specially designed to accurately model hydrogen bonding in water. The parameters of the revised model, denoted TCPE/2013, are here developed to reproduce the ab initio energetic and geometrical properties of small water clusters (up to hexamers) and the repulsive water interactions occurring in cation first hydration shells. The model parameters have also been refined to reproduce two liquid water properties at ambient conditions, the density and the vaporization enthalpy. Thanks to its computational efficiency, the new model range of applicability was validated by performing simulations of liquid water over a wide range of temperatures and pressures, as well as by investigating water liquid/vapor interfaces over a large range of temperatures. It is shown to reproduce several important water properties at an accurate enough level of precision, such as the existence liquid water density maxima up to a pressure of 1000 atm, the water boiling temperature, the properties of the water critical point (temperature, pressure, and density), and the existence of a "singularity" temperature at about 225 K in the supercooled regime. This model appears thus to be particularly well-suited for characterizing ion hydration properties under different temperature and pressure conditions, as well as in different phases and interfaces.

  14. Water Services in the Buenos Aires Metropolitan Area: How Does State Regulation Work?

    Directory of Open Access Journals (Sweden)

    Mariela Verónica Rocca

    2014-08-01

    Full Text Available This article deals with the State regulation of drinking water and sanitation services in the Metropolitan Area of Buenos Aires. Its main objective is to identify the continuities and ruptures in State regulation during the transition from private management (1993-2006 to renationalisation and State management (2006 onwards. The concept of “State capacities” (both administrative and relational is used to assess regulatory performance. For the administrative capacities, the correspondence between the design and resources of the agencies, as well as the differences between their formal functions and actual practices, is examined. For the relational capacities, the policies of the National Government and its interaction with both the water and sanitation companies and the regulatory and control agencies are considered. The analysis is based on official documents, legislation and statistics, company balance sheets and reports, newspaper articles and semi-structured interviews.

  15. EFFECTS OF CARVEDILOL AND METOPROLOL ON VEGETATIVE REGULATION OF HEART AND MICROCIRCULATION IN PATIENTS WITH HYPERTENSION AND HIGH BODY MASS

    Directory of Open Access Journals (Sweden)

    A. R. Kiselev

    2016-01-01

    Full Text Available Aim. To study effects of carvedilol and metoprolol on vegetative regulation of heart and microcirculatory vessels in patients with arterial hypertension (HT of 1-2 degrees and high body mass/obesity.Material and methods. Patients with HT of 1-2 degrees (n=25; aged 51±8 y.o. were included in the study. Registration of 0,1 Hz-fluctuations in heart rhythm variability and microcirculation change was performed during passive orthostatic test at spontaneous breath (duration of each test stage 10 min. Synchronization of 0,1 Hz-rhythms was estimated by calculation of phases difference and a numerical measure of synchronization. Frequency estimations of heart rhythm variability spectrum were performed in high and low frequency ranges additionaly.Results. Carvedilol and metoprolol have the comparable antihypertensive effect and influence on vegetative regulation of cardiovascular system in patients with HT. Both drugs have negative influence on synchronization of 0,1 Hz-rhythms in initially high systolic blood pressure level (>150 mm Hg.Conclusion. Carvedilol and metoprolol have comparable influence on synchronization of 0,1 Hz-rhythms in cardiovascular system.

  16. Hydrological and Meteorological Role of Forests: Implications for the Regulation of Water and Energy Balances

    Science.gov (United States)

    Salazar, J. F.; Villegas, J. C.; Bettin, D. M.; Molina, R.; Henao, J. J.; Rodríguez, E.; Rendón, A.; Hoyos, I.; Poveda, G.

    2016-12-01

    In last decades, there has been increasing debate about the hydrological and meteorological role of forests, particularly regarding its role in the regulation of the energy and water balances. Here we summarize results from an ongoing research program studying this problem. First, we introduce the notion of ecohydrological scaling to show the existence of two alternative states of regulated or unregulated streamflows in the main tributaries of the Amazon river basin. The transition between both states is associated with the loss of forest cover, with a potential critical threshold at around 40% forest loss in the Amazon. These results imply that large-scale forest loss can force the entire Amazon basin system beyond a critical threshold where its natural streamflow regulation is lost. More generally, our proposed framework provides insights for a physical interpretation of the scaling relations in river basins, as well as foundations and tools to develop early warnings of critical transitions in river basins. Second, we show that long-term rainfall-streamflow ratios converge to low values with low spatial variability in forested basins of the world, independent of location, climatic regime, basin size or forest type. We interpret this as evidence that high forest cover provides long-term regulation of the water balance. Third, we examine the linkage between the presence of tropical forests in South America and the long-term spatial distribution of continental precipitation, and found evidence suggesting that the Amazon forests enhance the atmospheric rivers flowing inland from the Atlantic ocean, particularly during the austral and boreal summers. The associated effects on precipitation may be highly relevant for water availability in river basins located downstream such atmospheric rivers, such as the La Plata and the Orinoco river basins. Finally, we explore the linkage between forest-induced temperature inversions and the vertical transport of atmospheric

  17. CONTRIBUTION TO THE KNOWLEDGE OF THE AVIFAUNA IN MARIA LIZAMBA AND ASSOCIATED BODIES OF WATER

    Directory of Open Access Journals (Sweden)

    Axel Fuentes-Moreno

    2011-11-01

    Full Text Available The state of Veracruz, Mexico has many water bodies which are used by both men and birds. This study surveyed the avifauna of the lagoons Maria Lizamba, la Piedra, and small sections of the rivers Camaron and Estanzuela in Tierra Blanca, Veracruz. During February 2010 visual surveys of these aquatic habitats were conducted by walking and motorboat, including vegetated areas and surrounding villages. Species were identified by comparing to field guides both visually using binoculars and identification of songs and calls. Forty nine species were documented and comprised 25 families. The most diverse families were the Ardeidae with 7 and Icteridae 6 species respectively. Sixteen families were represented by only a single species. We found 14 species of migratory birds and we found three species (Cathartes burrovianus, Psarocolius montezuma and Campylorhynchus rufinucha rufinucha considered to be at risk status according to the Mexican list of endangered and threatened species (NOM-059-SEMARNAT-2010. The avifauna was similar to that of the Alvarado Lagoon System, with between 17 % and 22 % of the species recently recorded there. The areas surrounding Maria Lizamba are used by numerous species of birds, however many species were aquatic and wintering migratory birds.

  18. Fungal Contaminants in Drinking Water Regulation? A Tale of Ecology, Exposure, Purification and Clinical Relevance

    Directory of Open Access Journals (Sweden)

    Monika Novak Babič

    2017-06-01

    Full Text Available Microbiological drinking water safety is traditionally monitored mainly by bacterial parameters that indicate faecal contamination. These parameters correlate with gastro-intestinal illness, despite the fact that viral agents, resulting from faecal contamination, are usually the cause. This leaves behind microbes that can cause illness other than gastro-intestinal and several emerging pathogens, disregarding non-endemic microbial contaminants and those with recent pathogenic activity reported. This white paper focuses on one group of contaminants known to cause allergies, opportunistic infections and intoxications: Fungi. It presents a review on their occurrence, ecology and physiology. Additionally, factors contributing to their presence in water distribution systems, as well as their effect on water quality are discussed. Presence of opportunistic and pathogenic fungi in drinking water can pose a health risk to consumers due to daily contact with water, via several exposure points, such as drinking and showering. The clinical relevance and influence on human health of the most common fungal contaminants in drinking water is discussed. Our goal with this paper is to place fungal contaminants on the roadmap of evidence based and emerging threats for drinking water quality safety regulations.

  19. Fungal Contaminants in Drinking Water Regulation? A Tale of Ecology, Exposure, Purification and Clinical Relevance

    Science.gov (United States)

    Novak Babič, Monika; Gunde-Cimerman, Nina; Vargha, Márta; Tischner, Zsófia; Magyar, Donát; Veríssimo, Cristina; Sabino, Raquel; Viegas, Carla; Meyer, Wieland; Brandão, João

    2017-01-01

    Microbiological drinking water safety is traditionally monitored mainly by bacterial parameters that indicate faecal contamination. These parameters correlate with gastro-intestinal illness, despite the fact that viral agents, resulting from faecal contamination, are usually the cause. This leaves behind microbes that can cause illness other than gastro-intestinal and several emerging pathogens, disregarding non-endemic microbial contaminants and those with recent pathogenic activity reported. This white paper focuses on one group of contaminants known to cause allergies, opportunistic infections and intoxications: Fungi. It presents a review on their occurrence, ecology and physiology. Additionally, factors contributing to their presence in water distribution systems, as well as their effect on water quality are discussed. Presence of opportunistic and pathogenic fungi in drinking water can pose a health risk to consumers due to daily contact with water, via several exposure points, such as drinking and showering. The clinical relevance and influence on human health of the most common fungal contaminants in drinking water is discussed. Our goal with this paper is to place fungal contaminants on the roadmap of evidence based and emerging threats for drinking water quality safety regulations.

  20. Body composition and hydration status changes in male and female open-water swimmers during an ultra-endurance event.

    Science.gov (United States)

    Weitkunat, Tim; Knechtle, Beat; Knechtle, Patrizia; Rüst, Christoph Alexander; Rosemann, Thomas

    2012-01-01

    Body mass changes during ultra-endurance performances have been described for running, cycling and for swimming in a heated pool. The present field study of 20 male and 11 female open-water swimmers investigated the changes in body composition and hydration status during an ultra-endurance event. Body mass, both estimated fat mass and skeletal muscle mass, haematocrit, plasma sodium concentration ([Na+]) and urine specific gravity were determined. Energy intake, energy expenditure and fluid intake were estimated. Males experienced significant reductions in body mass (-0.5 %) and skeletal muscle mass (-1.1 %) (P 0.05). Changes in percent body fat, fat mass, and fat-free mass were heterogeneous and did not reach statistical significance (P > 0.05) between gender groups. Fluid intake relative to plasma volume was higher in females than in males during the ultra-endurance event. Compared to males, females' average increase in haematocrit was 3.3 percentage points (pp) higher, urine specific gravity decrease 0.1 pp smaller, and plasma [Na+] 1.3 pp higher. The observed patterns of fluid intake, changes in plasma volume, urine specific gravity, and plasma [Na+] suggest that, particularly in females, a combination of fluid shift from blood vessels to interstitial tissue, facilitated by skeletal muscle damage, as well as exercise-associated hyponatremia had occurred. To summarise, changes in body composition and hydration status are different in male compared to female open-water ultra-endurance swimmers.

  1. Assessing Many-Body Effects of Water Self-Ions. I: OH-(H2O) n Clusters.

    Science.gov (United States)

    Egan, Colin K; Paesani, Francesco

    2018-04-10

    The importance of many-body effects in the hydration of the hydroxide ion (OH - ) is investigated through a systematic analysis of the many-body expansion of the interaction energy carried out at the CCSD(T) level of theory, extrapolated to the complete basis set limit, for the low-lying isomers of OH - (H 2 O) n clusters, with n = 1-5. This is accomplished by partitioning individual fragments extracted from the whole clusters into "groups" that are classified by both the number of OH - and water molecules and the hydrogen bonding connectivity within each fragment. With the aid of the absolutely localized molecular orbital energy decomposition analysis (ALMO-EDA) method, this structure-based partitioning is found to largely correlate with the character of different many-body interactions, such as cooperative and anticooperative hydrogen bonding, within each fragment. This analysis emphasizes the importance of a many-body representation of inductive electrostatics and charge transfer in modeling OH - hydration. Furthermore, the rapid convergence of the many-body expansion of the interaction energy also suggests a rigorous path for the development of analytical potential energy functions capable of describing individual OH - -water many-body terms, with chemical accuracy. Finally, a comparison between the reference CCSD(T) many-body interaction terms with the corresponding values obtained with various exchange-correlation functionals demonstrates that range-separated, dispersion-corrected, hybrid functionals exhibit the highest accuracy, while GGA functionals, with or without dispersion corrections, are inadequate to describe OH - -water interactions.

  2. Substituting sugar-sweetened beverages with water or milk is inversely associated with body fatness development from childhood to adolescence

    DEFF Research Database (Denmark)

    Zheng, Miaobing; Rangan, Anna; Olsen, Nanna Julie

    2015-01-01

    OBJECTIVE: The aim of this study was to examine the association between different types of beverage intake and substitution of sugar-sweetened beverages (SSBs) by water, milk, or 100% fruit juice in relation to 6-y change in body fatness. METHODS: A cohort of 9-y-old children (N = 358) who...... participated in the Danish part of the European Youth Heart Study was followed for development of body fatness over 6 y. Multivariate linear regression was used to examine the associations between beverage intake at baseline and change in body fatness (body mass index z score [BMIz]), waist circumference (WC......), and sum of four skinfolds (Σ4SF) over 6 y with adjustment for potential confounders. Substitution models were used to evaluate various beverages as alternatives to SSBs. RESULTS: SSB intake at age 9 y, but not intake of other beverages, was directly associated with subsequent 6-y changes in BMIz (β = 0...

  3. Down-regulation of POLYGALACTURONASE1 alters firmness, tensile strength and water loss in apple (Malus x domestica) fruit.

    Science.gov (United States)

    Atkinson, Ross G; Sutherland, Paul W; Johnston, Sarah L; Gunaseelan, Kularajathevan; Hallett, Ian C; Mitra, Deepali; Brummell, David A; Schröder, Roswitha; Johnston, Jason W; Schaffer, Robert J

    2012-08-02

    While there is now a significant body of research correlating apple (Malus x domestica) fruit softening with the cell wall hydrolase ENDO-POLYGALACTURONASE1 (PG1), there is currently little knowledge of its physiological effects in planta. This study examined the effect of down regulation of PG1 expression in 'Royal Gala' apples, a cultivar that typically has high levels of PG1, and softens during fruit ripening. PG1-suppressed 'Royal Gala' apples harvested from multiple seasons were firmer than controls after ripening, and intercellular adhesion was higher. Cell wall analyses indicated changes in yield and composition of pectin, and a higher molecular weight distribution of CDTA-soluble pectin. Structural analyses revealed more ruptured cells and free juice in pulled apart sections, suggesting improved integrity of intercellular connections and consequent cell rupture due to failure of the primary cell walls under stress. PG1-suppressed lines also had reduced expansion of cells in the hypodermis of ripe apples, resulting in more densely packed cells in this layer. This change in morphology appears to be linked with reduced transpirational water loss in the fruit. These findings confirm PG1's role in apple fruit softening and suggests that this is achieved in part by reducing cellular adhesion. This is consistent with previous studies carried out in strawberry but not with those performed in tomato. In apple PG1 also appears to influence other fruit texture characters such as juiciness and water loss.

  4. 78 FR 33700 - Special Local Regulations for Marine Events, Pleasantville Aquatics 15th Annual 5K Open Water...

    Science.gov (United States)

    2013-06-05

    ...-AA08 Special Local Regulations for Marine Events, Pleasantville Aquatics 15th Annual 5K Open Water Swim... Waterway for the Pleasantville Aquatics 15th Annual 5K Open Water Swim. The Captain of the Port, Sector..., Pleasantville Aquatics 15th Annual 5K Open Water Swim, Intracoastal Waterway; Atlantic City, NJ. (a) Location...

  5. Tribocorrosion in pressurized high temperature water: a mass flow model based on the third body approach

    Energy Technology Data Exchange (ETDEWEB)

    Guadalupe Maldonado, S.

    2014-07-01

    Pressurized water reactors (PWR) used for power generation are operated at elevated temperatures (280-300 °C) and under higher pressure (120-150 bar). In addition to these harsh environmental conditions some components of the PWR assemblies are subject to mechanical loading (sliding, vibration and impacts) leading to undesirable and hardly controllable material degradation phenomena. In such situations wear is determined by the complex interplay (tribocorrosion) between mechanical, material and physical-chemical phenomena. Tribocorrosion in PWR conditions is at present little understood and models need to be developed in order to predict component lifetime over several decades. The goal of this project, carried out in collaboration with the French company AREVA NP, is to develop a predictive model based on the mechanistic understanding of tribocorrosion of specific PWR components (stainless steel control assemblies, stellite grippers). The approach taken here is to describe degradation in terms of electro-chemical and mechanical material flows (third body concept of tribology) from the metal into the friction film (i.e. the oxidized film forming during rubbing on the metal surface) and from the friction film into the environment instead of simple mass loss considerations. The project involves the establishment of mechanistic models for describing the single flows based on ad-hoc tribocorrosion measurements operating at low temperature. The overall behaviour at high temperature and pressure in investigated using a dedicated tribometer (Aurore) including electrochemical control of the contact during rubbing. Physical laws describing the individual flows according to defined mechanisms and as a function of defined physical parameters were identified based on the obtained experimental results and from literature data. The physical laws were converted into mass flow rates and solved as differential equation system by considering the mass balance in compartments

  6. Cold Water Mediates Greater Reductions in Limb Blood Flow than Whole Body Cryotherapy.

    Science.gov (United States)

    Mawhinney, Chris; Low, David A; Jones, Helen; Green, Daniel J; Costello, Joseph T; Gregson, Warren

    2017-06-01

    Cold-water immersion (CWI) and whole body cryotherapy (WBC) are widely used recovery methods in an attempt to limit exercise-induced muscle damage, soreness, and functional deficits after strenuous exercise. The aim of this study was to compare the effects of ecologically valid CWI and WBC protocols on postexercise lower limb thermoregulatory, femoral artery, and cutaneous blood flow responses. Ten males completed a continuous cycle exercise protocol at 70% maximal oxygen uptake until a rectal temperature of 38°C was attained. Participants were then exposed to lower-body CWI (8°C) for 10 min, or WBC (-110°C) for 2 min, in a randomized crossover design. Rectal and thigh skin, deep, and superficial muscle temperatures, thigh, and calf skin blood flow (laser Doppler flowmetry), superficial femoral artery blood flow (duplex ultrasound), and arterial blood pressure were measured before, and for 40 min post, cooling interventions. Greater reductions in thigh skin (CWI, -5.9°C ± 1.8°C; WBC, 0.2°C ± 0.5°C; P < 0.001) and superficial (CWI, -4.4°C ± 1.3°C; WBC, -1.8°C ± 1.1°C; P < 0.001) and deep (CWI, -2.9°C ± 0.8°C; WBC, -1.3°C ± 0.6°C; P < 0.001) muscle temperatures occurred immediately after CWI. Decreases in femoral artery conductance were greater after CWI (CWI, -84% ± 11%; WBC, -59% ± 21%, P < 0.02) and thigh (CWI, -80% ± 5%; WBC, -59% ± 14%, P < 0.001), and calf (CWI, -73% ± 13%; WBC, -45% ± 17%, P < 0.001) cutaneous vasoconstriction was greater after CWI. Reductions in rectal temperature were similar between conditions after cooling (CWI, -0.6°C ± 0.4°C; WBC, -0.6°C ± 0.3°C; P = 0.98). Greater reductions in blood flow and tissue temperature were observed after CWI in comparison with WBC. These novel findings have practical and clinical implications for the use of cooling in the recovery from exercise and injury.

  7. Controlling of water collection ability by an elasticity-regulated bioinspired fiber.

    Science.gov (United States)

    Wang, Sijie; Feng, Shile; Hou, Yongping; Zheng, Yongmei

    2015-03-01

    A special artificial spider silk is presented which is fabricated by using both an elastic polymer and a fiber, and the water collection behavior is investigated. Through exerting tension in varying degree, the length of the three-phase contact line (TCL) and the area of spindle knot can be regulated readily, which makes a great contribution to the improvement of collecting efficiency and water-hanging ability. The water-hanging ability can be predicted at a given stretching ratio according to the given expression of the TCL. As a result, liquid capture or release of distinct measure can be achieved via exerting tension. This research is helpful to design smart materials for developing applications in fogwater collection, dehumidification, high-efficiency humidity control, and controllable adhesion. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Oxygen isotope fractionation between bird eggshell calcite and body water: application to fossil eggs from Lanzarote (Canary Islands)

    Science.gov (United States)

    Lazzerini, Nicolas; Lécuyer, Christophe; Amiot, Romain; Angst, Delphine; Buffetaut, Eric; Fourel, François; Daux, Valérie; Betancort, Juan Francisco; Flandrois, Jean-Pierre; Marco, Antonio Sánchez; Lomoschitz, Alejandro

    2016-10-01

    Oxygen and carbon isotope compositions of fossil bird eggshell calcite (δ18Ocalc and δ13Ccalc) are regularly used to reconstruct paleoenvironmental conditions. However, the interpretation of δ18Ocalc values of fossil eggshells has been limited to qualitative variations in local climatic conditions as oxygen isotope fractionations between calcite, body fluids, and drinking water have not been determined yet. For this purpose, eggshell, albumen water, and drinking water of extant birds have been analyzed for their oxygen and carbon isotope compositions. Relative enrichments in 18O relative to 16O between body fluids and drinking water of +1.6 ± 0.9 ‰ for semi-aquatic birds and of +4.4 ± 1.9 ‰ for terrestrial birds are observed. Surprisingly, no significant dependence to body temperature on the oxygen isotope fractionation between eggshell calcite and body fluids is observed, suggesting that bird eggshells precipitate out of equilibrium. Two empirical equations relating the δ18Ocalc value of eggshell calcite to the δ18Ow value of ingested water have been established for terrestrial and semi-aquatic birds. These equations have been applied to fossil eggshells from Lanzarote in order to infer the ecologies of the Pleistocene marine bird Puffinus sp. and of the enigmatic giant birds from the Pliocene. Both δ13Ccalc and δ18Ocalc values of Puffinus eggshells point to a semi-aquatic marine bird ingesting mostly seawater, whereas low δ13Ccalc and high δ18Ocalc values of eggshells from the Pliocene giant bird suggest a terrestrial lifestyle. This set of equations can help to quantitatively estimate the origin of waters ingested by extinct birds as well as to infer either local environmental or climatic conditions.

  9. The temporal dynamics of zooplankton communities of different types of water bodies within Ichniansky National Park

    Directory of Open Access Journals (Sweden)

    Z. V. Burian

    2017-05-01

    Full Text Available In recent decades, the influence of anthropogenic impact on aquatic ecosystems has increased. This has led to a restructuring of aquatic ecosystems and affected the structural and functional organization of groups of aquatic organisms, causing qualitative and quantitative changes. Particular attention is drawn to the different types of water bodies of protected areas like IchnyanskyNational Park, which is located in Ichnyansky district of Chernihiv region. This park is a newly created one, so the reduction in intensity of anthropogenic pressure can be traced within its waters. Zooplankton plays an important role in the functioning of trophic networks because it transfers energy from producers and primary consumers to young fish and planktonophagous fish. Therefore, three main groups of zooplankton were chosen as the object of study: rotifers (class Eurotatoria, cladocerans (class Branchiopoda, order Cladocera, different age stages of copepods (class Copepoda, and also ostracods (Class Ostracoda. The zooplankton used as research material was collected in the daytime in spring (April, summer (late July – early August and autumn (late September – early October in the years 2015–2016 from ten experimental stations. During this period 81 species of zooplankton were recorded within heterogeneous reservoirs of IchnianskyNational Park. Monogonont rotifers (subclass Monogononta included 35 species (43% of all species and bdelloid rotifers (subclass Bdelloidea, cladocerns, comprised 28 species (35%, and copepods included 18 species (22%. The faunal range of zooplankton over different years and seasons was characterized by the predominance of the rotator complex in spring, rotator-cladocerans and cladocerans in summer, and of the cladocerans complex in autumn. This was due to the formation during spring and summer of favourable conditions in the waters for filter feeders, which consist generally of rotifers and cladocerans. In autumn the water

  10. Adaptive Regulation of the Northern California Reservoir System for Water, Energy, and Environmental Management

    Science.gov (United States)

    Georgakakos, A. P.; Kistenmacher, M.; Yao, H.; Georgakakos, K. P.

    2014-12-01

    The 2014 National Climate Assessment o