The regulation of visitors conduction activity in the State System os Brazilian Conservation Units

Directory of Open Access Journals (Sweden)

Cristina Alves Nascimento

2016-08-01

Full Text Available Beyond to conserving biodiversity, conservation units must promote public use in contact with nature, assisting in increasing the economic resource of the area, approximating the society to nature and promoting their sustainable use. In Brazil, there are rules of the Ministry of Environment and Chico Mendes Institute for Biodiversity Conservation that regulate the conduction of visitors in federal conservation units. Remains to know how the activity is regulated in other spheres of the National Conservation Units System. Therefore, this article purpose to identify the legal basis for the conduction of visitors in the state conservation units and their adherence to guidelines of the Ministry of Environment. The methodology consisted in documentary research and data survey of the legal basis, done through visits to websites and sending e-mails to state management agencies. Adherence to the guidelines of the regulations was done through the evaluation to fulfillment or not from them. Legal basis were found in 18.5% of federal units of Brazil, being that only Espírito Santo and Rio de Janeiro meet almost all of the guideline. The conclusion was that there is a long way to go forward as the creation of rules and procedures that simultaneously encourage visitation accompanied to qualified conductors and biodiversity conservation. It is recommended greater efforts of state management agencies for the development of these legal basis, promoting improvements in desenvolviment of the activity and awareness of society.

Conserved properties of Drosophila Insomniac link sleep regulation and synaptic function.

Science.gov (United States)

Li, Qiuling; Kellner, David A; Hatch, Hayden A M; Yumita, Tomohiro; Sanchez, Sandrine; Machold, Robert P; Frank, C Andrew; Stavropoulos, Nicholas

2017-05-01

Sleep is an ancient animal behavior that is regulated similarly in species ranging from flies to humans. Various genes that regulate sleep have been identified in invertebrates, but whether the functions of these genes are conserved in mammals remains poorly explored. Drosophila insomniac (inc) mutants exhibit severely shortened and fragmented sleep. Inc protein physically associates with the Cullin-3 (Cul3) ubiquitin ligase, and neuronal depletion of Inc or Cul3 strongly curtails sleep, suggesting that Inc is a Cul3 adaptor that directs the ubiquitination of neuronal substrates that impact sleep. Three proteins similar to Inc exist in vertebrates-KCTD2, KCTD5, and KCTD17-but are uncharacterized within the nervous system and their functional conservation with Inc has not been addressed. Here we show that Inc and its mouse orthologs exhibit striking biochemical and functional interchangeability within Cul3 complexes. Remarkably, KCTD2 and KCTD5 restore sleep to inc mutants, indicating that they can substitute for Inc in vivo and engage its neuronal targets relevant to sleep. Inc and its orthologs localize similarly within fly and mammalian neurons and can traffic to synapses, suggesting that their substrates may include synaptic proteins. Consistent with such a mechanism, inc mutants exhibit defects in synaptic structure and physiology, indicating that Inc is essential for both sleep and synaptic function. Our findings reveal that molecular functions of Inc are conserved through ~600 million years of evolution and support the hypothesis that Inc and its orthologs participate in an evolutionarily conserved ubiquitination pathway that links synaptic function and sleep regulation.

CORECLUST: identification of the conserved CRM grammar together with prediction of gene regulation.

Science.gov (United States)

Nikulova, Anna A; Favorov, Alexander V; Sutormin, Roman A; Makeev, Vsevolod J; Mironov, Andrey A

2012-07-01

Identification of transcriptional regulatory regions and tracing their internal organization are important for understanding the eukaryotic cell machinery. Cis-regulatory modules (CRMs) of higher eukaryotes are believed to possess a regulatory 'grammar', or preferred arrangement of binding sites, that is crucial for proper regulation and thus tends to be evolutionarily conserved. Here, we present a method CORECLUST (COnservative REgulatory CLUster STructure) that predicts CRMs based on a set of positional weight matrices. Given regulatory regions of orthologous and/or co-regulated genes, CORECLUST constructs a CRM model by revealing the conserved rules that describe the relative location of binding sites. The constructed model may be consequently used for the genome-wide prediction of similar CRMs, and thus detection of co-regulated genes, and for the investigation of the regulatory grammar of the system. Compared with related methods, CORECLUST shows better performance at identification of CRMs conferring muscle-specific gene expression in vertebrates and early-developmental CRMs in Drosophila.

Restructuring and regulating district heating and cogeneration in transition economies

International Nuclear Information System (INIS)

Brendow, Klaus

2004-01-01

In summer 2004, the World Energy Council published a Study on 'Regulating district heating and cogeneration in central and eastern Europe'2, prepared by representatives from eleven economies in transition and two Nordic countries. The Task Force analysed twelve regulatory issues, country-by-country, on all internationally comparable basis. Regulatory progress on the road to more efficient, profitable, competitive and service-oriented heat supplies was described. Common concerns were identified: the need for independence of the regulator from policy and industry, improved coordination between central and local regulators and between environmental and energy authorities, access to grids, and a 'fair' sharing of CHP benefits among heat and electricity generation. Looking forward, the Task Force advocated a continued dialogue between decision makers, regulators, regulated industries and customers on: 1)the internalisation of DH/CHP benefits; 2)the future reduction of the density of regulation; 3) Joint implementation; 4)the compensation for public service obligations; 5)the elimination of old debt and stranded investments; 6) DH/CHP taxation; 7)privatisation; 8)the integration of DH/CHP in urban planning. A concluding WEC workshop in Moscow in March 2004 addressed recommendations to policy makers('Moscow Statement'). (Author)

Specific microRNAs Regulate Heat Stress Responses in Caenorhabditis elegans

DEFF Research Database (Denmark)

Nehammer, Camilla; Podolska, Agnieszka; Mackowiak, Sebastian D

2015-01-01

have identified additional functions for already known players (mir-71 and mir-239) as well as identifying mir-80 and the mir-229 mir-64-66 cluster as important regulators of the heat stress response in C. elegans. These findings uncover an additional layer of complexity to the regulation of stress...... to heat stress in Caenorhabditis elegans and show that a discrete subset of miRNAs is thermoregulated. Using in-depth phenotypic analyses of miRNA deletion mutant strains we reveal multiple developmental and post-developmental survival and behavioral functions for specific miRNAs during heat stress. We...

Conservative modelling of the moisture and heat transfer in building components under atmospheric excitation

DEFF Research Database (Denmark)

Janssen, Hans; Blocken, Bert; Carmeliet, Jan

2007-01-01

While the transfer equations for moisture and heat in building components are currently undergoing standardisation, atmospheric boundary conditions, conservative modelling and numerical efficiency are not addressed. In a first part, this paper adds a comprehensive description of those boundary...

Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators

Directory of Open Access Journals (Sweden)

Neal L. Millar

2012-01-01

Full Text Available Tendon disorders—tendinopathies—are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations. Whilst the molecular pathophysiology of tendinopathy remains difficult to interpret the disease process involving repetitive stress, and cellular load provides important mechanistic insight into the area of heat shock proteins which spans many disease processes in the autoimmune community. Heat shock proteins, also called damage-associated molecular patterns (DAMPs, are rapidly released following nonprogrammed cell death, are key effectors of the innate immune system, and critically restore homeostasis by promoting the reconstruction of the effected tissue. Our investigations have highlighted a key role for HSPs in tendion disease which may ultimately affect tissue rescue mechanisms in tendon pathology. This paper aims to provide an overview of the biology of heat shock proteins in soft tissue and how these mediators may be important regulators of inflammatory mediators and matrix regulation in tendinopathy.

Solar wind heat flux regulation by the whistler instability

International Nuclear Information System (INIS)

Gary, S.P.; Feldman, W.C.

1977-01-01

This paper studies the role of the whistler instability in the regulation of the solar wind heat flux near 1 AU. A comparison of linear and second-order theory with experimental results provides strong evidence that the whistler may at times contribute to the limitation of this heat flux

Energy conservation via heat transfer enhancement. Quarterly progress report, January 1-March 31, 1979

Energy Technology Data Exchange (ETDEWEB)

Bergles, A.E.; Junkhan, G.H.; Webb, R.L.

1979-06-01

This report for the first quarter of 1979 summarizes visits and contacts relative to the theory and practice of heat transfer enhancement. The Technical Literature File and Manufacturers' File were expanded, and the initial Patent Technology Information File was completed. Application studies on enhancement of waste heat recuperators and laminar internal flow heat transfer are described. A comprehensive bibliography on laminar flow enhancement is included. The Technology study on performance of internally finned tubes is complete. New data for the heat transfer and friction characteristics of internally finned tubes will be analyzed to develop rationally based correlations. An assessment of natural convection from rough surfaces was performed. Major effort was directed toward planning of the Research Workshop on Energy Conservation Through Enhanced Heat Transfer. The Workshop, scheduled for May 24 and May 25, 1979 in Chicago, will be co-sponsored by NSF.

Does electricity (and heat) network regulation have anything to learn from fixed line telecoms regulation?

International Nuclear Information System (INIS)

Pollitt, Michael

2010-01-01

The purpose of this paper is to examine the lessons from the recent history of telecoms deregulation for electricity (and by implication heat) network regulation. We do this in the context of Ofgem's RPI-X rate at 20 review of energy regulation in the UK, which considers whether RPI-X-based price regulation is fit for purpose after over 20 years of operation in energy networks. We examine the deregulation of fixed line telecoms in the UK and the lessons which it seems to suggest. We then apply the lessons to electricity networks in the context of a possible increase in distributed generation directly connected to local distribution networks. We conclude that there is the possibility of more parallels over time and suggest several implications of this for the regulation of electricity and heat networks. (author)

Plant elicitor peptides are conserved signals regulating direct and indirect antiherbivore defense

OpenAIRE

Huffaker, Alisa; Pearce, Gregory; Veyrat, Nathalie; Erb, Matthias; Turlings, Ted C. J.; Sartor, Ryan; Shen, Zhouxin; Briggs, Steven P.; Vaughan, Martha M.; Alborn, Hans T.; Teal, Peter E. A.; Schmelz, Eric A.

2013-01-01

Insect-induced defenses occur in nearly all plants and are regulated by conserved signaling pathways. As the first described plant peptide signal, systemin regulates antiherbivore defenses in the Solanaceae, but in other plant families, peptides with analogous activity have remained elusive. In the current study, we demonstrate that a member of the maize (Zea mays) plant elicitor peptide (Pep) family, ZmPep3, regulates responses against herbivores. Consistent with being a signal, expression o...

End users heat energy savings using thermostat regulation valves radiators, v. 16(64)

International Nuclear Information System (INIS)

Jakimovska, Emilija Misheva; Potsev, Eftim

2008-01-01

Billing the used heat energy offers the opportunity to motivate end users to use the heat energy rationally and to save the energy. Installing the thermostat valves on the radiators it is possible frequently to regulate the room temperature and to use the heat gains, obtaining comfortable climate in the apartments and saving the energy. Thermostat valves give the possibility to use the heat energy rationally and save the energy, and these way and users can regulate the heat energy consumption according to their own level of thermal comfort. (Author)

End users heat energy savings using thermostat regulation valves radiators, v. 16(63)

International Nuclear Information System (INIS)

Jakimovska, Emilija Misheva; Potsev, Eftim

2008-01-01

Billing the used heat energy offers the opportunity to motivate end users to use the heat energy rationally and to save the energy. Installing the thermostat valves on the radiators it is possible frequently to regulate the room temperature and to use the heat gains, obtaining comfortable climate in the apartments and saving the energy. Thermostat valves give the possibility to use the heat energy rationally and save the energy, and these way and users can regulate the heat energy consumption according to their own level of thermal comfort. (Author)

75 FR 20111 - Energy Conservation Program: Energy Conservation Standards for Residential Water Heaters, Direct...

Science.gov (United States)

2010-04-16

... Program: Energy Conservation Standards for Residential Water Heaters, Direct Heating Equipment, and Pool... heating equipment and pool heaters. Table I.1--Amended Energy Conservation Standards for Residential Water... for national energy and water conservation; and 7. Other factors the Secretary of Energy (Secretary...

Regulation models for district heating. Main report; Denmark; Reguleringsmodeller for fjernvarmen. Hovedrapport

Energy Technology Data Exchange (ETDEWEB)

2012-02-15

With regard to choice of model for the regulation of district heating prices the report points out that a detailed analysis of a cost+ model could be considered. Such an analysis could provide further definition of the extended right to recoup the investment for heating companies, the shaping of the possibility of recognition of opportunity costs and the fixed cost allocation, and the clarified definition of necessary costs. The report also suggests that a price cap regulation or a completely free pricing in the entire sector is hardly appropriate forms of regulation. The report's analysis clearly shows that the choice of price regulation in the heat sector has impact on the incentives in terms of investment, green conversion, etc. It also appears that the different regulatory models have very different advantages and disadvantages, and lessons learned from other sectors and abroad show that changing price regulation rules can be a difficult and lengthy process with unintended consequences along the way. (LN)

Forkhead Box M1 Is Regulated by Heat Shock Factor 1 and Promotes Glioma Cells Survival under Heat Shock Stress*

Science.gov (United States)

Dai, Bingbing; Gong, Aihua; Jing, Zhitao; Aldape, Kenneth D.; Kang, Shin-Hyuk; Sawaya, Raymond; Huang, Suyun

2013-01-01

The forkhead box M1 (FoxM1) is a key transcription factor regulating multiple aspects of cell biology. Prior studies have shown that FoxM1 is overexpressed in a variety of human tumors, including brain tumor, and plays a critical role in cancer development and progression. In this study we found that FoxM1 was up-regulated by heat shock factor 1 (HSF1) under heat shock stress condition in multiple cell lines. Knockdown of HSF1 with HSF1 siRNA or inhibition of HSF1 with a HSF1 inhibitor abrogated heat shock-induced expression of FoxM1. Genetic deletion of HSF1 in mouse embryo fibroblast cells also abolished heat shock stress-induced FoxM1 expression. Moreover, we showed that HSF1 directly bound to FoxM1 promoter and increased FoxM1 promoter activity. Furthermore, we demonstrated that FoxM1 was required for the G2-M phase progression through regulating Cdc2, Cdc20, and Cdc25B under a mild heat shock stress but enhanced cell survival under lethal heat shock stress condition. Finally, in human glioblastoma specimens, FoxM1 overexpression correlated with elevated HSF1 expression. Our results indicate that FoxM1 is regulated by HSF1 and is critical for HSF1-mediated heat shock response. We demonstrated a novel mechanism of stress resistance controlled by HSF1 and a new HSF-FoxM1 connection that mediates cellular thermotolerance. PMID:23192351

Emotion Regulation as the Foundation of Political Attitudes: Does Reappraisal Decrease Support for Conservative Policies?

Science.gov (United States)

Lee, Jooa Julia; Sohn, Yunkyu; Fowler, James H.

2013-01-01

Cognitive scientists, behavior geneticists, and political scientists have identified several ways in which emotions influence political attitudes, and psychologists have shown that emotion regulation can have an important causal effect on physiology, cognition, and subjective experience. However, no work to date explores the possibility that emotion regulation may shape political ideology and attitudes toward policies. Here, we conduct four studies that investigate the role of a particular emotion regulation strategy – reappraisal in particular. Two observational studies show that individual differences in emotion regulation styles predict variation in political orientations and support for conservative policies. In the third study, we experimentally induce disgust as the target emotion to be regulated and show that use of reappraisal reduces the experience of disgust, thereby decreasing moral concerns associated with conservatism. In the final experimental study, we show that use of reappraisal successfully attenuates the relationship between trait-level disgust sensitivity and support for conservative policies. Our findings provide the first evidence of a critical link between emotion regulation and political attitudes. PMID:24367583

Emotion regulation as the foundation of political attitudes: does reappraisal decrease support for conservative policies?

Directory of Open Access Journals (Sweden)

Jooa Julia Lee

Full Text Available Cognitive scientists, behavior geneticists, and political scientists have identified several ways in which emotions influence political attitudes, and psychologists have shown that emotion regulation can have an important causal effect on physiology, cognition, and subjective experience. However, no work to date explores the possibility that emotion regulation may shape political ideology and attitudes toward policies. Here, we conduct four studies that investigate the role of a particular emotion regulation strategy--reappraisal in particular. Two observational studies show that individual differences in emotion regulation styles predict variation in political orientations and support for conservative policies. In the third study, we experimentally induce disgust as the target emotion to be regulated and show that use of reappraisal reduces the experience of disgust, thereby decreasing moral concerns associated with conservatism. In the final experimental study, we show that use of reappraisal successfully attenuates the relationship between trait-level disgust sensitivity and support for conservative policies. Our findings provide the first evidence of a critical link between emotion regulation and political attitudes.

Heat flux expressions that satisfy the conservation laws in atomistic system involving multibody potentials

Energy Technology Data Exchange (ETDEWEB)

Fu, Yao, E-mail: Yao.Fu@colorado.edu; Song, Jeong-Hoon, E-mail: JH.Song@colorado.edu

2015-08-01

Heat flux expressions are derived for multibody potential systems by extending the original Hardy's methodology and modifying Admal & Tadmor's formulas. The continuum thermomechanical quantities obtained from these two approaches are easy to compute from molecular dynamics (MD) results, and have been tested for a constant heat flux model in two distinctive systems: crystalline iron and polyethylene (PE) polymer. The convergence criteria and affecting parameters, i.e. spatial and temporal window size, and specific forms of localization function are found to be different between the two systems. The conservation of mass, momentum, and energy are discussed and validated within this atomistic–continuum bridging.

Heat flux expressions that satisfy the conservation laws in atomistic system involving multibody potentials

International Nuclear Information System (INIS)

Fu, Yao; Song, Jeong-Hoon

2015-01-01

Heat flux expressions are derived for multibody potential systems by extending the original Hardy's methodology and modifying Admal & Tadmor's formulas. The continuum thermomechanical quantities obtained from these two approaches are easy to compute from molecular dynamics (MD) results, and have been tested for a constant heat flux model in two distinctive systems: crystalline iron and polyethylene (PE) polymer. The convergence criteria and affecting parameters, i.e. spatial and temporal window size, and specific forms of localization function are found to be different between the two systems. The conservation of mass, momentum, and energy are discussed and validated within this atomistic–continuum bridging

75 FR 12144 - Energy Conservation Program for Consumer Products: Energy Conservation Standards for Residential...

Science.gov (United States)

2010-03-15

.... 1. Consensus Agreement On January 26, 2010, the Air-Conditioning, Heating and Refrigeration... subsections. B. History of the Standards Rulemaking for Residential Furnaces 1. Background Energy conservation... recommending minimum energy conservation standards for residential central air conditioners, heat pumps, and...

Regulation of G-protein coupled receptor traffic by an evolutionary conserved hydrophobic signal.

Science.gov (United States)

Angelotti, Tim; Daunt, David; Shcherbakova, Olga G; Kobilka, Brian; Hurt, Carl M

2010-04-01

Plasma membrane (PM) expression of G-protein coupled receptors (GPCRs) is required for activation by extracellular ligands; however, mechanisms that regulate PM expression of GPCRs are poorly understood. For some GPCRs, such as alpha2c-adrenergic receptors (alpha(2c)-ARs), heterologous expression in non-native cells results in limited PM expression and extensive endoplasmic reticulum (ER) retention. Recently, ER export/retentions signals have been proposed to regulate cellular trafficking of several GPCRs. By utilizing a chimeric alpha(2a)/alpha(2c)-AR strategy, we identified an evolutionary conserved hydrophobic sequence (ALAAALAAAAA) in the extracellular amino terminal region that is responsible in part for alpha(2c)-AR subtype-specific trafficking. To our knowledge, this is the first luminal ER retention signal reported for a GPCR. Removal or disruption of the ER retention signal dramatically increased PM expression and decreased ER retention. Conversely, transplantation of this hydrophobic sequence into alpha(2a)-ARs reduced their PM expression and increased ER retention. This evolutionary conserved hydrophobic trafficking signal within alpha(2c)-ARs serves as a regulator of GPCR trafficking.

Guidelines and incentives for conservation development in local land-use regulations.

Science.gov (United States)

Reed, Sarah E; Hilty, Jodi A; Theobald, David M

2014-02-01

Effective conservation of biological diversity on private lands will require changes in land-use policy and development practice. Conservation development (CD) is an alternative form of residential development in which homes are built on smaller lots and clustered together and the remainder of the property is permanently protected for conservation purposes. We assessed the degree to which CD is permitted and encouraged by local land-use regulations in 414 counties in the western United States. Thirty-two percent of local planning jurisdictions have adopted CD ordinances, mostly within the past 10 years. CD ordinances were adopted in counties with human population densities that were 3.0 times greater and in counties with 2.5 times more land use at urban, suburban, and exurban densities than counties without CD ordinances. Despite strong economic incentives for CD (e.g., density bonuses, which allow for a mean of 66% more homes to be built per subdivision area), several issues may limit the effectiveness of CD for biological diversity conservation. Although most CD ordinances required a greater proportion of the site area be protected than in a typical residential development, just 13% (n = 17) of the ordinances required an ecological site analysis to identify and map features that should be protected. Few CD ordinances provided guidelines regarding the design and configuration of the protected lands, including specifying a minimum size for protected land parcels or encouraging contiguity with other protected lands within or near to the site. Eight percent (n =11) of CD ordinances encouraged consultation with a biological expert or compliance with a conservation plan. We recommend that conservation scientists help to improve the effectiveness of CD by educating planning staff and government officials regarding biological diversity conservation, volunteering for their local planning boards, or consulting on development reviews. © 2013 Society for Conservation

Energy conservation in flame-heated hearth furnaces in aluminium foundries. Pt. 1

Energy Technology Data Exchange (ETDEWEB)

Moser, R

1981-01-01

There are two fields for energy saving: The aluminium foundries obtain the electrolytic metal in liquid form and therefore also excessive heat. This must be used. The furnaces must be designed and operated so that they use as little energy as possible. Both subjects are investigated by considering 59 existing plants in Europe. They are compared regarding energy consumption and heat balance. A series of possibilities for improved use of fuel, such as improvement of the burner setting, automatic regulation of excess air and use of combustion with enriched oxygen supply are given.

Unraveling regulation of the small heat shock proteins by the heat shock factor HvHsfB2c in barley: its implications in drought stress response and seed development.

Science.gov (United States)

Reddy, Palakolanu Sudhakar; Kavi Kishor, Polavarapu B; Seiler, Christiane; Kuhlmann, Markus; Eschen-Lippold, Lennart; Lee, Justin; Reddy, Malireddy K; Sreenivasulu, Nese

2014-01-01

The rapid increase in heat shock proteins upon exposure to damaging stresses and during plant development related to desiccation events reveal their dual importance in plant development and stress tolerance. Genome-wide sequence survey identified 20 non-redundant small heat shock proteins (sHsp) and 22 heat shock factor (Hsf) genes in barley. While all three major classes (A, B, C) of Hsfs are localized in nucleus, the 20 sHsp gene family members are localized in different cell organelles like cytoplasm, mitochondria, plastid and peroxisomes. Hsf and sHsp members are differentially regulated during drought and at different seed developmental stages suggesting the importance of chaperone role under drought as well as seed development. In silico cis-regulatory motif analysis of Hsf promoters showed an enrichment with abscisic acid responsive cis-elements (ABRE), implying regulatory role of ABA in mediating transcriptional response of HvsHsf genes. Gene regulatory network analysis identified HvHsfB2c as potential central regulator of the seed-specific expression of several HvsHsps including 17.5CI sHsp. These results indicate that HvHsfB2c is co-expressed in the central hub of small Hsps and therefore it may be regulating the expression of several HvsHsp subclasses HvHsp16.88-CI, HvHsp17.5-CI and HvHsp17.7-CI. The in vivo relevance of binding specificity of HvHsfB2C transcription factor to HSE-element present in the promoter of HvSHP17.5-CI under heat stress exposure is confirmed by gel shift and LUC-reporter assays. Further, we isolated 477 bp cDNA from barley encoding a 17.5 sHsp polypeptide, which was predominantly upregulated under drought stress treatments and also preferentially expressed in developing seeds. Recombinant HvsHsp17.5-CI protein was expressed in E. coli and purified to homogeneity, which displayed in vitro chaperone activity. The predicted structural model of HvsHsp-17.5-CI protein suggests that the α-crystallin domain is evolutionarily highly

Unraveling regulation of the small heat shock proteins by the heat shock factor HvHsfB2c in barley: its implications in drought stress response and seed development.

Directory of Open Access Journals (Sweden)

Palakolanu Sudhakar Reddy

Full Text Available The rapid increase in heat shock proteins upon exposure to damaging stresses and during plant development related to desiccation events reveal their dual importance in plant development and stress tolerance. Genome-wide sequence survey identified 20 non-redundant small heat shock proteins (sHsp and 22 heat shock factor (Hsf genes in barley. While all three major classes (A, B, C of Hsfs are localized in nucleus, the 20 sHsp gene family members are localized in different cell organelles like cytoplasm, mitochondria, plastid and peroxisomes. Hsf and sHsp members are differentially regulated during drought and at different seed developmental stages suggesting the importance of chaperone role under drought as well as seed development. In silico cis-regulatory motif analysis of Hsf promoters showed an enrichment with abscisic acid responsive cis-elements (ABRE, implying regulatory role of ABA in mediating transcriptional response of HvsHsf genes. Gene regulatory network analysis identified HvHsfB2c as potential central regulator of the seed-specific expression of several HvsHsps including 17.5CI sHsp. These results indicate that HvHsfB2c is co-expressed in the central hub of small Hsps and therefore it may be regulating the expression of several HvsHsp subclasses HvHsp16.88-CI, HvHsp17.5-CI and HvHsp17.7-CI. The in vivo relevance of binding specificity of HvHsfB2C transcription factor to HSE-element present in the promoter of HvSHP17.5-CI under heat stress exposure is confirmed by gel shift and LUC-reporter assays. Further, we isolated 477 bp cDNA from barley encoding a 17.5 sHsp polypeptide, which was predominantly upregulated under drought stress treatments and also preferentially expressed in developing seeds. Recombinant HvsHsp17.5-CI protein was expressed in E. coli and purified to homogeneity, which displayed in vitro chaperone activity. The predicted structural model of HvsHsp-17.5-CI protein suggests that the α-crystallin domain is

Regulation and energy conservation. The case of combined heat and power in the European Union. Situation and prospects

International Nuclear Information System (INIS)

Hendriks, C.; Worrell, E.; Blok, K.; Velthuijsen, J.W.

1995-02-01

Policy measures to stimulate the proliferation of combined heat and power generation (CHP) have been motivated because of the energy efficiency potential. In this paper we investigate to what extent the penetration of CHP has taken place in the 12 member states of the European Union (EU-12). Also analyzed is the potential heat demand which can be covered by CHP, and the corresponding amount of capacity for each country. A short overview is given of the goals for CHP capacity for some of the EU-12 member states. We distinguish two different kinds of policy instruments: standard settings and economic instruments. Four different types of standard settings are given. We evaluate a specific standard setting which is applied in the Netherlands in the 1970's and early 1980's. The economic instruments are evaluated in terms of payback time. This payback period can be influenced by for instance an investment grant, tax on the emission of carbon dioxide, a raise of selling electricity to the public grid and lower the price for natural gas for CHP applications. Finally, we give some recommendations how EU policy may stimulate the application of CHP. In section 2 we describe the development of CHP from 1974 to 1990 in the EU-12 member states. and the intentions stated by the national governments. In section 3 we give an overview of the potential capacity of CHP. In section 4 we discuss the regulation instruments: standard settings and economical instruments. In section 5 we give some conclusions especially with regard to EU policy options. 23 refs

Hovering in the heat: effects of environmental temperature on heat regulation in foraging hummingbirds.

Science.gov (United States)

Powers, Donald R; Langland, Kathleen M; Wethington, Susan M; Powers, Sean D; Graham, Catherine H; Tobalske, Bret W

2017-12-01

At high temperature (greater than 40°C) endotherms experience reduced passive heat dissipation (radiation, conduction and convection) and increased reliance on evaporative heat loss. High temperatures challenge flying birds due to heat produced by wing muscles. Hummingbirds depend on flight for foraging, yet inhabit hot regions. We used infrared thermography to explore how lower passive heat dissipation during flight impacts body-heat management in broad-billed ( Cynanthus latirostris , 3.0 g), black-chinned ( Archilochus alexandri , 3.0 g), Rivoli's ( Eugenes fulgens , 7.5 g) and blue-throated ( Lampornis clemenciae , 8.0 g) hummingbirds in southeastern Arizona and calliope hummingbirds ( Selasphorus calliope , 2.6 g) in Montana. Thermal gradients driving passive heat dissipation through eye, shoulder and feet dissipation areas are eliminated between 36 and 40°C. Thermal gradients persisted at higher temperatures in smaller species, possibly allowing them to inhabit warmer sites. All species experienced extended daytime periods lacking thermal gradients. Broad-billed hummingbirds lacking thermal gradients regulated the mean total-body surface temperature at approximately 38°C, suggesting behavioural thermoregulation. Blue-throated hummingbirds were inactive when lacking passive heat dissipation and hence might have the lowest temperature tolerance of the four species. Use of thermal refugia permitted hummingbirds to tolerate higher temperatures, but climate change could eliminate refugia, forcing distributional shifts in hummingbird populations.

HSF1 and HSF3 cooperatively regulate the heat shock response in lizards.

Science.gov (United States)

Takii, Ryosuke; Fujimoto, Mitsuaki; Matsuura, Yuki; Wu, Fangxu; Oshibe, Namiko; Takaki, Eiichi; Katiyar, Arpit; Akashi, Hiroshi; Makino, Takashi; Kawata, Masakado; Nakai, Akira

2017-01-01

Cells cope with temperature elevations, which cause protein misfolding, by expressing heat shock proteins (HSPs). This adaptive response is called the heat shock response (HSR), and it is regulated mainly by heat shock transcription factor (HSF). Among the four HSF family members in vertebrates, HSF1 is a master regulator of HSP expression during proteotoxic stress including heat shock in mammals, whereas HSF3 is required for the HSR in birds. To examine whether only one of the HSF family members possesses the potential to induce the HSR in vertebrate animals, we isolated cDNA clones encoding lizard and frog HSF genes. The reconstructed phylogenetic tree of vertebrate HSFs demonstrated that HSF3 in one species is unrelated with that in other species. We found that the DNA-binding activity of both HSF1 and HSF3 in lizard and frog cells was induced in response to heat shock. Unexpectedly, overexpression of lizard and frog HSF3 as well as HSF1 induced HSP70 expression in mouse cells during heat shock, indicating that the two factors have the potential to induce the HSR. Furthermore, knockdown of either HSF3 or HSF1 markedly reduced HSP70 induction in lizard cells and resistance to heat shock. These results demonstrated that HSF1 and HSF3 cooperatively regulate the HSR at least in lizards, and suggest complex mechanisms of the HSR in lizards as well as frogs.

Water conservation benefits of urban heat mitigation: can cooling strategies reduce water consumption in California?

Science.gov (United States)

Vahmani, P.; Jones, A. D.

2017-12-01

Urban areas are at the forefront of climate mitigation and adaptation efforts given their high concentration of people, industry, and infrastructure. Many cities globally are seeking strategies to counter the consequences of both a hotter and drier climate. While urban heat mitigation strategies have been shown to have beneficial effects on health, energy consumption, and greenhouse gas emissions, their implications for water conservation have not been widely examined. Here we show that broad implementation of cool roofs, an urban heat mitigation strategy, not only results in significant cooling of air temperature, but also meaningfully decreases outdoor water consumption by reducing evaporative and irrigation water demands. Based on a suite of satellite-supported, multiyear regional climate simulations, we find that cool roof adoption has the potential to reduce outdoor water consumption across the major metropolitan areas in California by up to 9%. Irrigation water savings per capita, induced by cool roofs, range from 1.8 to 15.4 gallons per day across 18 counties examined. Total water savings in Los Angeles county alone is about 83 million gallons per day. While this effect is robust across the 15 years examined (2001-2015), including both drought and non-drought years, we find that cool roofs are most effective during the hottest days of the year, indicating that they could play an even greater role in reducing outdoor water use in a hotter future climate. We further show that this synergistic relationship between heat mitigation and water conservation is asymmetrical - policies that encourage direct reductions in irrigation water use can lead to substantial regional warming, potentially conflicting with heat mitigation efforts designed to counter the effects of the projected warming climate.

New market based price regulation on combined heat and power in Denmark

International Nuclear Information System (INIS)

Koch, Jesper; Nielsen, Marianne; Hansen, Anders B.; Lawaetz, Henrik

2003-01-01

Major economic risks can become reality when local co-generation plants (L-CHP ) meet the full market penetration with new market based price regulation. Co-generation produces more than 50% of the national electricity consumption and half of the production is generated from L-CHP. The new price regulation is assumed to take action in 2004. The paper will present an analysis of a market based price regulation on the L-CHP-sector. The paper will spotlight on L-CHP in district heating systems supplying heat for domestic purposes. When smaller and medium sized CHP sell electricity they are paid an average price of 46 Euro per MWh. The return of selling electricity shall primarily cover the expenditure of buying gas for electricity production and writing off investments cost of a CHP-plant. With the framework of today it is a fact that the plants (in average) are only slightly competitive compared to individual heat production plants. When CHP meet market conditions there is a high risk that electricity prices will be reduced significantly (prices of 20 - 30 Euro per MWh) for a longer period. Significantly reduced electricity prices will result in dramatically increased heat prices. If no action is taken there will be a potential risk that heat consumers in the smaller and medium sized cities together must pay an extra bill of 200 million Euro each year. It corresponds to an average increase of the heating bill of 300 - 500 Euro per year for an average house. This is far from acceptable. There will also be a high risk that companies with industrial CHP will permanently convert to heat only boiler and only use their CHP occasionally because CHP plants might not be cost-effective when electricity prices are low. These effects can cause a significant increase of the national CO 2 emission

Gene co-regulation is highly conserved in the evolution of eukaryotes and prokaryotes.

NARCIS (Netherlands)

Snel, B.; Noort, V. van; Huynen, M.A.

2004-01-01

Differences between species have been suggested to largely reside in the network of connections among the genes. Nevertheless, the rate at which these connections evolve has not been properly quantified. Here, we measure the extent to which co-regulation between pairs of genes is conserved over

Regulation of Heat Exchange across the Hornbill Beak: Functional Similarities with Toucans?

Science.gov (United States)

van de Ven, T M F N; Martin, R O; Vink, T J F; McKechnie, A E; Cunningham, S J

2016-01-01

Beaks are increasingly recognised as important contributors to avian thermoregulation. Several studies supporting Allen's rule demonstrate how beak size is under strong selection related to latitude and/or air temperature (Ta). Moreover, active regulation of heat transfer from the beak has recently been demonstrated in a toucan (Ramphastos toco, Ramphastidae), with the large beak acting as an important contributor to heat dissipation. We hypothesised that hornbills (Bucerotidae) likewise use their large beaks for non-evaporative heat dissipation, and used thermal imaging to quantify heat exchange over a range of air temperatures in eighteen desert-living Southern Yellow-billed Hornbills (Tockus leucomelas). We found that hornbills dissipate heat via the beak at air temperatures between 30.7°C and 41.4°C. The difference between beak surface and environmental temperatures abruptly increased when air temperature was within ~10°C below body temperature, indicating active regulation of heat loss. Maximum observed heat loss via the beak was 19.9% of total non-evaporative heat loss across the body surface. Heat loss per unit surface area via the beak more than doubled at Ta > 30.7°C compared to Ta hornbills, and thus had a larger potential for heat loss at lower air temperatures. Respiratory cooling (panting) thresholds were also lower in toucans compared to hornbills. Both beak vasodilation and panting threshold temperatures are potentially explained by differences in acclimation to environmental conditions and in the efficiency of evaporative cooling under differing environmental conditions. We speculate that non-evaporative heat dissipation may be a particularly important mechanism for animals inhabiting humid regions, such as toucans, and less critical for animals residing in more arid conditions, such as Southern Yellow-billed Hornbills. Alternatively, differences in beak morphology and hardness enforced by different diets may affect the capacity of birds to use

Application of the HN method to radiative heat transfer for a non-conservative slab

International Nuclear Information System (INIS)

Bulut, S.; Guelecyuez, M.C.

2008-01-01

The H N method is used to calculate the partial fluxes relevant to radiative transfer in a plane parallel medium for linearly anisotropic scattering with specularly and diffusely reflecting boundaries. The solutions are obtained for the non-conservative case. The numerical values of the heat flux functions at the boundaries of the medium are calculated for the two source functions. The numerical results and the convergence of the H N method are compared with earlier results. (orig.)

Heat Shock Protein 90 regulates encystation in Entamoeba

Directory of Open Access Journals (Sweden)

Meetali eSingh

2015-10-01

Full Text Available Enteric protozoan Entamoeba histolytica is a major cause of debilitating diarrheal infection worldwide with high morbidity and mortality. Even though the clinical burden of this parasite is very high, this infection is categorized as a neglected disease. Parasite is transmitted through feco-oral route and exhibit two distinct stages namely – trophozoites and cysts. Mechanism and regulation of encystation is not clearly understood. Previous studies have established the role of Heat shock protein 90 (Hsp90 in regulating stage transition in various protozoan parasites like Giardia, Plasmodium, Leishmania and Toxoplasma. Our study for the first time reports that Hsp90 plays a crucial role in life cycle of Entamoeba as well. We identify Hsp90 to be a negative regulator of encystation in Entamoeba. We also show that Hsp90 inhibition interferes with the process of phagocytosis in Entamoeba. Overall, we show that Hsp90 plays an important role in virulence and transmission of Entamoeba.

Differential regulation by heat stress of novel cytochrome P450 genes from the dinoflagellate symbionts of reef-building corals.

Science.gov (United States)

Rosic, Nedeljka N; Pernice, Mathieu; Dunn, Simon; Dove, Sophie; Hoegh-Guldberg, Ove

2010-05-01

Exposure to heat stress has been recognized as one of the major factors leading to the breakdown of the coral-alga symbiosis and coral bleaching. Here, we describe the presence of three new cytochrome P450 (CYP) genes from the reef-building coral endosymbiont Symbiodinium (type C3) and changes in their expression during exposure to severe and moderate heat stress conditions. Sequence analysis of the CYP C-terminal region and two conserved domains, the "PERF" and "heme-binding" domains, confirmed the separate identities of the CYP genes analyzed. In order to explore the effects of different heat stress scenarios, samples of the scleractinian coral Acropora millepora were exposed to elevated temperatures incrementally over an 18-h period (rapid thermal stress) and over a 120-h period (gradual thermal stress). After 18 h of gradual heating and incubation at 26 degrees C, the Symbiodinium CYP mRNA pool was approximately 30% larger, while a further 6 degrees C increase to a temperature above the average sea temperature (29 degrees C after 72 h) resulted in a 2- to 4-fold increase in CYP expression. Both rapid heat stress and gradual heat stress at 32 degrees C resulted in 50% to 90% decreases in CYP gene transcript abundance. Consequently, the initial upregulation of expression of CYP genes at moderately elevated temperatures (26 degrees C and 29 degrees C) was followed by a decrease in expression under the greater thermal stress conditions at 32 degrees C. These findings indicate that in the coral-alga symbiosis under heat stress conditions there is production of chemical stressors and/or transcriptional factors that regulate the expression of genes, such as the genes encoding cytochrome P450 monooxygenases, that are involved in the first line of an organism's chemical defense.

Energy conservation in buildings: a subject not to be swept under the carpet anymore

Energy Technology Data Exchange (ETDEWEB)

Kunde, W

1977-04-01

Energy shortages and price increases make the consumer conscious of having to show more concern for appropriate behavior, but conservation measures which are technically feasible and economically necessary cannot be obtained without legal regulations. Measures not only the gas supply companies have to deal with, but also the sanitary, heating and building industry are pointed out.

Regulation of Heat Exchange across the Hornbill Beak: Functional Similarities with Toucans?

Directory of Open Access Journals (Sweden)

T M F N van de Ven

Full Text Available Beaks are increasingly recognised as important contributors to avian thermoregulation. Several studies supporting Allen's rule demonstrate how beak size is under strong selection related to latitude and/or air temperature (Ta. Moreover, active regulation of heat transfer from the beak has recently been demonstrated in a toucan (Ramphastos toco, Ramphastidae, with the large beak acting as an important contributor to heat dissipation. We hypothesised that hornbills (Bucerotidae likewise use their large beaks for non-evaporative heat dissipation, and used thermal imaging to quantify heat exchange over a range of air temperatures in eighteen desert-living Southern Yellow-billed Hornbills (Tockus leucomelas. We found that hornbills dissipate heat via the beak at air temperatures between 30.7°C and 41.4°C. The difference between beak surface and environmental temperatures abruptly increased when air temperature was within ~10°C below body temperature, indicating active regulation of heat loss. Maximum observed heat loss via the beak was 19.9% of total non-evaporative heat loss across the body surface. Heat loss per unit surface area via the beak more than doubled at Ta > 30.7°C compared to Ta < 30.7°C and at its peak dissipated 25.1 W m-2. Maximum heat flux rate across the beak of toucans under comparable convective conditions was calculated to be as high as 61.4 W m-2. The threshold air temperature at which toucans vasodilated their beak was lower than that of the hornbills, and thus had a larger potential for heat loss at lower air temperatures. Respiratory cooling (panting thresholds were also lower in toucans compared to hornbills. Both beak vasodilation and panting threshold temperatures are potentially explained by differences in acclimation to environmental conditions and in the efficiency of evaporative cooling under differing environmental conditions. We speculate that non-evaporative heat dissipation may be a particularly important

Heat pipe based cold energy storage systems for datacenter energy conservation

International Nuclear Information System (INIS)

Singh, Randeep; Mochizuki, Masataka; Mashiko, Koichi; Nguyen, Thang

2011-01-01

system concept. -- Highlights: → The paper presents novel concept for datacenter thermal management using heat-pipe based energy conservation system utilizing cold ambient energy. → Two type of system: ice storage and cold water storage has been identified and discussed. → Ice storage or two-phase system can provide long term storage and can be used as datacenter emergency support system. → Cold water or single-phase system can be employed as precooler for coolant before it is cooled by electrical chiller. → These two types of storage approaches can help to minimize chiller electrical load thus saving electricity and associated cost.

Heat shock and plant leachates regulate seed germination of the endangered carnivorous plant Drosophyllum lusitanicum

Directory of Open Access Journals (Sweden)

S. Gómez-González

2018-01-01

Full Text Available In fire-prone ecosystems, many plant species have specialized mechanisms of seed dormancy that ensure a successful recruitment after fire. A well-documented mechanism is the germination stimulated by fire-related cues, such as heat shock and smoke. However, less is known about the role of inhibitory germination signals (e.g. allelopathy in regulating post-fire recruitment. Plant leachates derived from the unburned vegetation can enforce dormancy by means of allelopathic compounds, acting as a signal of unfavourable (highly competitive niche for germination in pyrophyte species. Here, we assessed the separate effects of heat shock and plant leachates on seed germination of Drosophyllum lusitanicum, an endangered carnivorous plant endemic to Mediterranean fire-prone heathlands. We performed a germination experiment in which seeds were subjected to three treatments: (1 5 min at 100 °C, (2 watering with plant leachate, and (3 control. Germination rate and seed viability was determined after 63 days. Heat shock stimulated seed germination in D. lusitanicum while plant leachates had inhibitory germination effects without reducing seed viability. Thus, both positive and negative signals could be involved in its successful post-fire recruitment. Fire would break seed dormancy and stimulate seed germination of D. lusitanicum through high temperatures, but also by eliminating allelochemical compounds from the soil. These results help to understand the population dynamics patterns found for D. lusitanicum in natural populations, and highlight the role of fire in the ecology and conservation of this endangered species. Seed dormancy imposed by plant-derived leachates as an adaptive mechanism should be considered more in fire ecology theory.

A new hydraulic regulation method on district heating system with distributed variable-speed pumps

International Nuclear Information System (INIS)

Wang, Hai; Wang, Haiying; Zhu, Tong

2017-01-01

Highlights: • A hydraulic regulation method was presented for district heating with distributed variable speed pumps. • Information and automation technologies were utilized to support the proposed method. • A new hydraulic model was developed for distributed variable speed pumps. • A new optimization model was developed based on genetic algorithm. • Two scenarios of a multi-source looped system was illustrated to validate the method. - Abstract: Compared with the hydraulic configuration based on the conventional central circulating pump, a district heating system with distributed variable-speed-pumps configuration can often save 30–50% power consumption on circulating pumps with frequency inverters. However, the hydraulic regulations on distributed variable-speed-pumps configuration could be more complicated than ever while all distributed pumps need to be adjusted to their designated flow rates. Especially in a multi-source looped structure heating network where the distributed pumps have strongly coupled and severe non-linear hydraulic connections with each other, it would be rather difficult to maintain the hydraulic balance during the regulations. In this paper, with the help of the advanced automation and information technologies, a new hydraulic regulation method was proposed to achieve on-site hydraulic balance for the district heating systems with distributed variable-speed-pumps configuration. The proposed method was comprised of a new hydraulic model, which was developed to adapt the distributed variable-speed-pumps configuration, and a calibration model with genetic algorithm. By carrying out the proposed method step by step, the flow rates of all distributed pumps can be progressively adjusted to their designated values. A hypothetic district heating system with 2 heat sources and 10 substations was taken as a case study to illustrate the feasibility of the proposed method. Two scenarios were investigated respectively. In Scenario I, the

1D momentum-conserving systems: the conundrum of anomalous versus normal heat transport

International Nuclear Information System (INIS)

Li, Yunyun; Li, Nianbei; Hänggi, Peter; Li, Baowen; Liu, Sha

2015-01-01

Transport and the spread of heat in Hamiltonian one dimensional momentum conserving nonlinear systems is commonly thought to proceed anomalously. Notable exceptions, however, do exist of which the coupled rotator model is a prominent case. Therefore, the quest arises to identify the origin of manifest anomalous energy and momentum transport in those low dimensional systems. We develop the theory for both, the statistical densities for momentum- and energy-spread and particularly its momentum-/heat-diffusion behavior, as well as its corresponding momentum/heat transport features. We demonstrate that the second temporal derivative of the mean squared deviation of the momentum spread is proportional to the equilibrium correlation of the total momentum flux. Subtracting the part which corresponds to a ballistic momentum spread relates (via this integrated, subleading momentum flux correlation) to an effective viscosity, or equivalently, to the underlying momentum diffusivity. We next put forward the intriguing hypothesis: normal spread of this so adjusted excess momentum density causes normal energy spread and alike normal heat transport (Fourier Law). Its corollary being that an anomalous, superdiffusive broadening of this adjusted excess momentum density in turn implies an anomalous energy spread and correspondingly anomalous, superdiffusive heat transport. This hypothesis is successfully corroborated within extensive molecular dynamics simulations over large extended time scales. Our numerical validation of the hypothesis involves four distinct archetype classes of nonlinear pair-interaction potentials: (i) a globally bounded pair interaction (the noted coupled rotator model), (ii) unbounded interactions acting at large distances (the coupled rotator model amended with harmonic pair interactions), (iii) the case of a hard point gas with unbounded square-well interactions and (iv) a pair interaction potential being unbounded at short distances while displaying an

1D momentum-conserving systems: the conundrum of anomalous versus normal heat transport

Science.gov (United States)

Li, Yunyun; Liu, Sha; Li, Nianbei; Hänggi, Peter; Li, Baowen

2015-04-01

Transport and the spread of heat in Hamiltonian one dimensional momentum conserving nonlinear systems is commonly thought to proceed anomalously. Notable exceptions, however, do exist of which the coupled rotator model is a prominent case. Therefore, the quest arises to identify the origin of manifest anomalous energy and momentum transport in those low dimensional systems. We develop the theory for both, the statistical densities for momentum- and energy-spread and particularly its momentum-/heat-diffusion behavior, as well as its corresponding momentum/heat transport features. We demonstrate that the second temporal derivative of the mean squared deviation of the momentum spread is proportional to the equilibrium correlation of the total momentum flux. Subtracting the part which corresponds to a ballistic momentum spread relates (via this integrated, subleading momentum flux correlation) to an effective viscosity, or equivalently, to the underlying momentum diffusivity. We next put forward the intriguing hypothesis: normal spread of this so adjusted excess momentum density causes normal energy spread and alike normal heat transport (Fourier Law). Its corollary being that an anomalous, superdiffusive broadening of this adjusted excess momentum density in turn implies an anomalous energy spread and correspondingly anomalous, superdiffusive heat transport. This hypothesis is successfully corroborated within extensive molecular dynamics simulations over large extended time scales. Our numerical validation of the hypothesis involves four distinct archetype classes of nonlinear pair-interaction potentials: (i) a globally bounded pair interaction (the noted coupled rotator model), (ii) unbounded interactions acting at large distances (the coupled rotator model amended with harmonic pair interactions), (iii) the case of a hard point gas with unbounded square-well interactions and (iv) a pair interaction potential being unbounded at short distances while displaying an

Price-structure of electricity and district-heating. A background study for energy conservation programme

International Nuclear Information System (INIS)

1994-01-01

The present report deals with the pricing and price-structure of electricity and district-heating with their effects on energy saving. It constitutes part of the groundwork for the new Government Energy Conservation Programme. The report describes principles for the pricing of electricity and district-heating in Finland, and gives some examples of tariffs in foreign countries, which are interesting from the point of view of energy saving. Different utilities apply quite similar pricing principles but there are big differences in price levels between the utilities. The difference in consumer prices can be almost 100 % in the case of electricity and over 150 % as concerns district-heating. The change in retail prices in the last ten years has not had a big general impact on the consumption of electricity or on energy saving. On the other hand, when the price increases of individual utilities are studied, the impact on energy saving at least in the short term can be seen. It seems that an increase of the fixed charges in relation to energy rates has been as a general trend after 1990. To promote energy saving the changing energy rates should be given special emphasis in determining electricity and district-heating tariffs. The opening of the electricity market means that the electricity suppliers face a new situation also when pricing their products. Customers and their expectations will play an increasingly role. (orig.)

Distinct Skeletal Muscle Gene Regulation from Active Contraction, Passive Vibration, and Whole Body Heat Stress in Humans.

Directory of Open Access Journals (Sweden)

Michael A Petrie

Full Text Available Skeletal muscle exercise regulates several important metabolic genes in humans. We know little about the effects of environmental stress (heat and mechanical stress (vibration on skeletal muscle. Passive mechanical stress or systemic heat stress are often used in combination with many active exercise programs. We designed a method to deliver a vibration stress and systemic heat stress to compare the effects with active skeletal muscle contraction.The purpose of this study is to examine whether active mechanical stress (muscle contraction, passive mechanical stress (vibration, or systemic whole body heat stress regulates key gene signatures associated with muscle metabolism, hypertrophy/atrophy, and inflammation/repair.Eleven subjects, six able-bodied and five with chronic spinal cord injury (SCI participated in the study. The six able-bodied subjects sat in a heat stress chamber for 30 minutes. Five subjects with SCI received a single dose of limb-segment vibration or a dose of repetitive electrically induced muscle contractions. Three hours after the completion of each stress, we performed a muscle biopsy (vastus lateralis or soleus to analyze mRNA gene expression.We discovered repetitive active muscle contractions up regulated metabolic transcription factors NR4A3 (12.45 fold, PGC-1α (5.46 fold, and ABRA (5.98 fold; and repressed MSTN (0.56 fold. Heat stress repressed PGC-1α (0.74 fold change; p < 0.05; while vibration induced FOXK2 (2.36 fold change; p < 0.05. Vibration similarly caused a down regulation of MSTN (0.74 fold change; p < 0.05, but to a lesser extent than active muscle contraction. Vibration induced FOXK2 (p < 0.05 while heat stress repressed PGC-1α (0.74 fold and ANKRD1 genes (0.51 fold; p < 0.05.These findings support a distinct gene regulation in response to heat stress, vibration, and muscle contractions. Understanding these responses may assist in developing regenerative rehabilitation interventions to improve muscle cell

The expression of miR-125b regulates angiogenesis during the recovery of heat-denatured HUVECs.

Science.gov (United States)

Zhou, Situo; Zhang, Pihong; Liang, Pengfei; Huang, Xiaoyuan

2015-06-01

In previous studies we found that miR-125b was down-regulated in denatured dermis of deep partial thickness burn patients. Moreover, miR-125b inhibited tumor-angiogenesis associated with the decrease of ERBB2 and VEGF expression in ovarian cancer cells and breast cancer cells, etc. In this study, we investigated the expression patterns and roles of miR-125b during the recovery of denatured dermis and heat-denatured human umbilical vein endothelial cells (HUVECs). Deep partial thickness burns in Sprague-Dawley rats and the heat-denatured cells (52°C, 35 s) were used for analysis. Western blot analysis and real-time PCR were applied to evaluate the expression of miR-125b and ERBB2 and VEGF. The ability of angiogenesis in heat-denatured HUVECs was analyzed by scratch wound healing and tube formation assay after pri-miR-125b or anti-miR-125b transfection. miR-125b expression was time-dependent during the recovery of heat-denatured dermis and HUVECs. Moreover, miR-125b regulated ERBB2 mRNA and Protein Expression and regulated angiogenesis association with regulating the expression of VEGF in heat-denatured HUVECs. Taken together our results show that the expression of miR-125b is time-dependent and miR-125b plays a regulatory role of angiogenesis during wound healing after burns. Copyright © 2014 Elsevier Ltd and ISBI. All rights reserved.

DEVELOPMENT OF THE HEAT PUMP MARKET IN POLAND IN RELATION TO NEW LEGAL REGULATIONS

Directory of Open Access Journals (Sweden)

Anna Wachowicz-Pyzik

2015-10-01

Full Text Available Heat pump market in Poland is one of the most dynamically developing branches of renewable energy sources (RES. Installations using different types of low-temperature heat pumps are becoming more and more popular especially among owners of detached houses. The article presents the characteristics of the heat pump market in Poland in recent years. Most important changes introduced on 20 February 2015 in the Act on Renewable Energy Sources (Journal of Laws 2015 pos. 478, were discussed. Also future prospects associated with increased use of heat pumps installations in the face of new regulations were analyzed.

A conserved serine residue regulates the stability of Drosophila Salvador and human WW domain-containing adaptor 45 through proteasomal degradation

Energy Technology Data Exchange (ETDEWEB)

Wu, Di, E-mail: DiWu@mail.nankai.edu.cn; Wu, Shian

2013-04-19

Highlights: •Ser-17 is key for the stability of Drosophila Sav. •Ala mutation of Ser-17 promotes the proteasomal degradation of Sav. •Ser-17 residue is not the main target of Hpo-induced Sav stabilization. •Hpo-dependent and -independent mechanisms regulate Sav stability. •This mechanism is conserved in the homologue of Sav, human WW45. -- Abstract: The Hippo (Hpo) pathway is a conserved tumor suppressor pathway that controls organ size through the coordinated regulation of apoptosis and proliferation. Drosophila Salvador (Sav), which limits organ size, is a core component of the Hpo pathway. In this study, Ser-17 was shown to be important for the stability of Sav. Alanine mutation of Ser-17 promoted the proteasomal degradation of Sav. Destabilization and stabilization of the Sav protein mediated by alanine mutation of Ser-17 and by Hpo, respectively, were independent of each other. This implies that the stability of Sav is controlled by two mechanisms, one that is Ser-17-dependent and Hpo-independent, and another that is Ser-17-independent and Hpo-dependent. These dual mechanisms also regulated the human counterpart of Drosophila Sav, WW domain-containing adaptor 45 (WW45). The conservation of this regulation adds to its significance in normal physiology and tumorigenesis.

Genome-wide discovery and differential regulation of conserved and novel microRNAs in chickpea via deep sequencing.

Science.gov (United States)

Jain, Mukesh; Chevala, V V S Narayana; Garg, Rohini

2014-11-01

MicroRNAs (miRNAs) are essential components of complex gene regulatory networks that orchestrate plant development. Although several genomic resources have been developed for the legume crop chickpea, miRNAs have not been discovered until now. For genome-wide discovery of miRNAs in chickpea (Cicer arietinum), we sequenced the small RNA content from seven major tissues/organs employing Illumina technology. About 154 million reads were generated, which represented more than 20 million distinct small RNA sequences. We identified a total of 440 conserved miRNAs in chickpea based on sequence similarity with known miRNAs in other plants. In addition, 178 novel miRNAs were identified using a miRDeep pipeline with plant-specific scoring. Some of the conserved and novel miRNAs with significant sequence similarity were grouped into families. The chickpea miRNAs targeted a wide range of mRNAs involved in diverse cellular processes, including transcriptional regulation (transcription factors), protein modification and turnover, signal transduction, and metabolism. Our analysis revealed several miRNAs with differential spatial expression. Many of the chickpea miRNAs were expressed in a tissue-specific manner. The conserved and differential expression of members of the same miRNA family in different tissues was also observed. Some of the same family members were predicted to target different chickpea mRNAs, which suggested the specificity and complexity of miRNA-mediated developmental regulation. This study, for the first time, reveals a comprehensive set of conserved and novel miRNAs along with their expression patterns and putative targets in chickpea, and provides a framework for understanding regulation of developmental processes in legumes. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology.

What Can We Learn about Workplace Heat Stress Management from a Safety Regulator Complaints Database?

Science.gov (United States)

Hansen, Alana; Pisaniello, Dino; Varghese, Blesson; Rowett, Shelley; Hanson-Easey, Scott; Bi, Peng; Nitschke, Monika

2018-03-06

Heat exposure can be a health hazard for many Australian workers in both outdoor and indoor situations. With many heat-related incidents left unreported, it is often difficult to determine the underlying causal factors. This study aims to provide insights into perceptions of potentially unsafe or uncomfortably hot working conditions that can affect occupational health and safety using information provided by the public and workers to the safety regulator in South Australia (SafeWork SA). Details of complaints regarding heat exposure to the regulator's "Help Centre" were assembled in a dataset and the textual data analysed thematically. The findings showed that the majority of calls relate to indoor work environments such as kitchens, factories, and warehouses. The main themes identified were work environment, health effects, and organisational issues. Impacts of hot working conditions ranged from discomfort to serious heat-related illnesses. Poor management practices and inflexibility of supervisors featured strongly amongst callers' concerns. With temperatures predicted to increase and energy prices escalating, this timely study, using naturalistic data, highlights accounts of hot working conditions that can compromise workers' health and safety and the need for suitable measures to prevent heat stress. These could include risk assessments to assess the likelihood of heat stress in workplaces where excessively hot conditions prevail.

75 FR 21981 - Energy Conservation Program: Energy Conservation Standards for Residential Water Heaters, Direct...

Science.gov (United States)

2010-04-27

... DEPARTMENT OF ENERGY 10 CFR Part 430 [Docket Number EE-2006-BT-STD-0129] RIN 1904-AA90 Energy Conservation Program: Energy Conservation Standards for Residential Water Heaters, Direct Heating Equipment, and Pool Heaters Correction In rule document 2010-7611 beginning on page 20112 in the issue of Friday...

A review of building energy regulation and policy for energy conservation in developing countries

International Nuclear Information System (INIS)

Iwaro, Joseph; Mwasha, Abraham

2010-01-01

The rapid growth of energy use, worldwide, hfs raised concerns over problems of energy supply and exhaustion of energy resources. Most of the developed countries are implementing building energy regulations such as energy standards, codes etc., to reduce building energy consumption. The position of developing countries with respect to energy regulations implementation and enforcement is either poorly documented or not documented at all. In addition, there is a lack of consistent data, which makes it difficult to understand the underlying changes that affect energy regulation implementation in developing countries. In that respect, this paper investigates the progress of building energy regulations in developing countries and its implication for energy conservation and efficiency. The present status of building energy regulations in 60 developing countries around the world was analysed through a survey of building energy regulations using online survey. The study revealed the present progress made on building energy regulations in relation to implementation, development and compliance; at the same time the study recommends possible solutions to the barriers facing building energy regulation implementation in the developing world. - Research Highlights: →Progress and implications of energy regulations in developing countries. →Investigation assessed the progress made on energy regulations using online survey. →Energy regulation activities is progressively increasing in developing countries. →The study identified 25 developing countries without energy regulatory standards. →The study shows relationship between energy regulation and energy consumption.

Cloning, characterization, and heat stress-induced redistribution of a protein homologous to human hsp27 in the zebrafish Danio rerio

International Nuclear Information System (INIS)

Mao Li; Bryantsev, Anton L.; Chechenova, Maria B.; Shelden, Eric A.

2005-01-01

Hsp27 is a small heat shock protein (shsp) regulating stress tolerance and increasingly thought to play roles in tissue homeostasis and differentiation. The zebrafish Danio rerio is an important model for the study of developmental processes, but little is known regarding shsps in this animal. Here, we report the sequence, expression, regulation, and function of a zebrafish protein (zfHsp27) homologous to human Hsp27. zfHsp27 contains three conserved phosphorylatable serines and a cysteine important for regulation of apoptosis, but it lacks much of a C-terminal tail domain and shows low homology in two putative actin interacting domains that are features of mammalian Hsp27. zfHsp27 mRNA is most abundant in adult skeletal muscle and heart and is upregulated during early embryogenesis. zfHsp27 expressed in mammalian fibroblasts was phosphorylated in response to heat stress and anisomycin, and this phosphorylation was prevented by treatment with SB202190, an inhibitor of p38 MAPK. Expression of zfHsp27 and human Hsp27 in mammalian fibroblasts promoted a similar degree of tolerance to heat stress. zfHsp27 fusion proteins entered the nucleus and associated with the cytoskeleton of heat stressed cells in vitro and in zebrafish embryos. These results reveal conservation in regulation and function of mammalian and teleost Hsp27 proteins and define zebrafish as a new model for the study of Hsp27 function

Heat pumps and heat exchangers in cow and pig houses in the Nordic countries. Utilization potentials

Energy Technology Data Exchange (ETDEWEB)

Pedersen, S [Statens Jordbrugstekniske Forsoeg, Horsens, Denmark

1985-01-01

An assessment is made of how many heat pumps it may be possible to establish in animal buildings in the Danish, Swedish, Norwegian, Finnish, and Icelandic agriculture. This assessment is based on the present livestock structure. Furthermore information is given of the yearly oil conservation that theoretically can be obtained, provided heat pumps and heat exchangers are installed every where with a sufficient livestock basis. The largest energy conservation can be obtained by heat recovery in cow- and pig houses and by heat exchangers in production of piglets.

A laser pointer driven microheater for precise local heating and conditional gene regulation in vivo. Microheater driven gene regulation in zebrafish

Directory of Open Access Journals (Sweden)

Achermann Marc

2009-12-01

Full Text Available Abstract Background Tissue heating has been employed to study a variety of biological processes, including the study of genes that control embryonic development. Conditional regulation of gene expression is a particularly powerful approach for understanding gene function. One popular method for mis-expressing a gene of interest employs heat-inducible heat shock protein (hsp promoters. Global heat shock of hsp-promoter-containing transgenic animals induces gene expression throughout all tissues, but does not allow for spatial control. Local heating allows for spatial control of hsp-promoter-driven transgenes, but methods for local heating are cumbersome and variably effective. Results We describe a simple, highly controllable, and versatile apparatus for heating biological tissue and other materials on the micron-scale. This microheater employs micron-scale fiber optics and uses an inexpensive laser-pointer as a power source. Optical fibers can be pulled on a standard electrode puller to produce tips of varying sizes that can then be used to reliably heat 20-100 μm targets. We demonstrate precise spatiotemporal control of hsp70l:GFP transgene expression in a variety of tissue types in zebrafish embryos and larvae. We also show how this system can be employed as part of a new method for lineage tracing that would greatly facilitate the study of organogenesis and tissue regulation at any time in the life cycle. Conclusion This versatile and simple local heater has broad utility for the study of gene function and for lineage tracing. This system could be used to control hsp-driven gene expression in any organism simply by bringing the fiber optic tip in contact with the tissue of interest. Beyond these uses for the study of gene function, this device has wide-ranging utility in materials science and could easily be adapted for therapeutic purposes in humans.

Class IIa histone deacetylases are conserved regulators of circadian function.

Science.gov (United States)

Fogg, Paul C M; O'Neill, John S; Dobrzycki, Tomasz; Calvert, Shaun; Lord, Emma C; McIntosh, Rebecca L L; Elliott, Christopher J H; Sweeney, Sean T; Hastings, Michael H; Chawla, Sangeeta

2014-12-05

Class IIa histone deacetylases (HDACs) regulate the activity of many transcription factors to influence liver gluconeogenesis and the development of specialized cells, including muscle, neurons, and lymphocytes. Here, we describe a conserved role for class IIa HDACs in sustaining robust circadian behavioral rhythms in Drosophila and cellular rhythms in mammalian cells. In mouse fibroblasts, overexpression of HDAC5 severely disrupts transcriptional rhythms of core clock genes. HDAC5 overexpression decreases BMAL1 acetylation on Lys-537 and pharmacological inhibition of class IIa HDACs increases BMAL1 acetylation. Furthermore, we observe cyclical nucleocytoplasmic shuttling of HDAC5 in mouse fibroblasts that is characteristically circadian. Mutation of the Drosophila homolog HDAC4 impairs locomotor activity rhythms of flies and decreases period mRNA levels. RNAi-mediated knockdown of HDAC4 in Drosophila clock cells also dampens circadian function. Given that the localization of class IIa HDACs is signal-regulated and influenced by Ca(2+) and cAMP signals, our findings offer a mechanism by which extracellular stimuli that generate these signals can feed into the molecular clock machinery. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Conservation and Renewable Energy Program: Bibliography, 1988 edition

Energy Technology Data Exchange (ETDEWEB)

Vaughan, K.H. (comp.)

1988-04-01

The 831 references covering the period 1980 through Feb. 1988, are arranged under the following: analysis and evaluation, building equipment, building thermal envelope systems and materials, community systems and cogeneration, residential conservation service, retrofit, advanced heat engine ceramics, alternative fuels, microemulsion fuels, industrial chemical heat pumps, materials for waste heat utilization, energy conversion and utilization materials, tribology, emergency energy conservation,inventions, electric energy systems, thermal storage, biofuels production, biotechnology, solar technology, geothermal, and continuous chromatography in multicomponent separations. An author index is included.

Refrigeration Playbook. Heat Reclaim; Optimizing Heat Rejection and Refrigeration Heat Reclaim for Supermarket Energy Conservation

Energy Technology Data Exchange (ETDEWEB)

Reis, Chuck [CTA Architects Engineers, Boise, ID (United States); Nelson, Eric [CTA Architects Engineers, Boise, ID (United States); Armer, James [CTA Architects Engineers, Boise, ID (United States); Johnson, Tim [CTA Architects Engineers, Boise, ID (United States); Hirsch, Adam [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Doebber, Ian [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

2015-03-01

The purpose of this playbook and accompanying spreadsheets is to generalize the detailed CBP analysis and to put tools in the hands of experienced refrigeration designers to evaluate multiple applications of refrigeration waste heat reclaim across the United States. Supermarkets with large portfolios of similar buildings can use these tools to assess the impact of large-scale implementation of heat reclaim systems. In addition, the playbook provides best practices for implementing heat reclaim systems to achieve the best long-term performance possible. It includes guidance on operations and maintenance as well as measurement and verification.

Federal regulation of the pipeline industry: a summary review. [Effects on use of energy-conservation technology

Energy Technology Data Exchange (ETDEWEB)

Banks, W. F.

1977-05-31

The principal purposes of this report are: (1) identification of the jurisdiction areas of the Federal pipeline-regulating agencies, and (2) examination of the amenability of the regulatory system to the introduction of energy-conservative new technology into the pipeline industry. The history, scope, and agency structure of state and Federal regulation are recounted and some gaps, overlaps, and ambiguities are identified. The only significant inhibitory effects upon technological innovation are found to derive from the FPC and ICC limits upon profit, the 1941 Justice Department consent decree limiting dividends to shipper-owned pipelines, and the income tax rules governing recovery of investment credits and startup losses. Effects of these limits are explored by simulation studies using the Systems, Science and Software pipeline economic model (PEM). Two new concepts of regulation are proposed which would neutralize the inhibitory effect of the present regulatory system and would motivate pipeline operators to conserve energy: (1) use of a ''national equivalent value'' in the economic tradeoff analyses which justify entry of a technological innovation into the rate base (valuation), and (2) a ''valuation allowance'' which would reverse the presently often-existing situation and insure that the pipeline operator would realize a greater profit from saving energy than from wasting it.

Confinement and dynamical regulation in two-dimensional convective turbulence

DEFF Research Database (Denmark)

Bian, N.H.; Garcia, O.E.

2003-01-01

In this work the nature of confinement improvement implied by the self-consistent generation of mean flows in two-dimensional convective turbulence is studied. The confinement variations are linked to two distinct regulation mechanisms which are also shown to be at the origin of low......-frequency bursting in the fluctuation level and the convective heat flux integral, both resulting in a state of large-scale intermittency. The first one involves the control of convective transport by sheared mean flows. This regulation relies on the conservative transfer of kinetic energy from tilted fluctuations...

Hood River Conservation Project load analysis

Energy Technology Data Exchange (ETDEWEB)

Stovall, T.K.

1987-11-01

As a part of the Hood River Conservation Project (HRCP), 314 homes were monitored to measure electrical energy use. The total electrical load, space heating load, water heating load (in about 200 homes), wood-stove heat output (in about 100 homes), and indoor temperature were monitored. Data were collected for one full year before and one full year after these homes were retrofit with conservation measures. Local weather information was also collected on a 15-min basis. This data base was used to evaluate the load savings attributable to HRCP. Two methods of weather normalization were used and showed close agreement. The weather-normalized diversified residential load savings on the Pacific Power and Light system and Hood River area peak days were >0.5 kW/household. The average spring, summer, and fall savings were much smaller, <0.1 kW/household. The load factor for the diversified residential load decreased following the conservation retrofit actions. 11 refs., 40 figs., 13 tabs.

TG2 regulates the heat-shock response by the post-translational modification of HSF1.

Science.gov (United States)

Rossin, Federica; Villella, Valeria Rachela; D'Eletto, Manuela; Farrace, Maria Grazia; Esposito, Speranza; Ferrari, Eleonora; Monzani, Romina; Occhigrossi, Luca; Pagliarini, Vittoria; Sette, Claudio; Cozza, Giorgio; Barlev, Nikolai A; Falasca, Laura; Fimia, Gian Maria; Kroemer, Guido; Raia, Valeria; Maiuri, Luigi; Piacentini, Mauro

2018-05-11

Heat-shock factor 1 (HSF1) is the master transcription factor that regulates the response to proteotoxic stress by controlling the transcription of many stress-responsive genes including the heat-shock proteins. Here, we show a novel molecular mechanism controlling the activation of HSF1. We demonstrate that transglutaminase type 2 (TG2), dependent on its protein disulphide isomerase activity, triggers the trimerization and activation of HSF1 regulating adaptation to stress and proteostasis impairment. In particular, we find that TG2 loss of function correlates with a defect in the nuclear translocation of HSF1 and in its DNA-binding ability to the HSP70 promoter. We show that the inhibition of TG2 restores the unbalance in HSF1-HSP70 pathway in cystic fibrosis (CF), a human disorder characterized by deregulation of proteostasis. The absence of TG2 leads to an increase of about 40% in CFTR function in a new experimental CF mouse model lacking TG2. Altogether, these results indicate that TG2 plays a key role in the regulation of cellular proteostasis under stressful cellular conditions through the modulation of the heat-shock response. © 2018 The Authors.

76 FR 71835 - Energy Conservation Program: Energy Conservation Standards for Direct Heating Equipment

Science.gov (United States)

2011-11-18

..., Public Meeting Transcript, No. 14 at pp. 94-95) The Air- conditioning, Heating, and Refrigeration... realistic simulation of a wood burning fire in a wood burning fireplace, not to provide heat. (R.H. Peterson...

Effect of two plant growth regulators and illumination conditions in the germination of conserved seeds of Clitoria ternatea

Directory of Open Access Journals (Sweden)

Maribel Quintana

2013-04-01

Full Text Available The seeds viability lost in the seed legume bank of Research Institute of Pastures and Forages (IIPF led to the aim of the work it was to determine the effect of two plant growth regulators (gibberellic acid; GA3 and naphthalene acetic acid; ANA and illumination conditions on the germination of Clitoria ternatea SC-136 conserved seeds. One experiment was performed with two-factor completely randomized design with four replications Five different levels of growth regulators (factor A and two illumination conditions (factor B were evaluated. The variables measured were: total germination percentage (PTG and angular transformation, days to 50% PTG (G50 and the days between 10 and 90% PTG (G10-90. In addition, morphological variables were evaluated. It was found that the addition of plant growth regulators (GA3 and NAA was effective in increasing germination of Clitoria ternatea SC-136 conserved seeds, but not the illumination conditions tested. Combination GA3 (1 mg l-1 and NAA (0.1 mg l-1 to stimulate germination was recommended. Key words: GA3, germplasm, legume, NAA, photoperiod.

Electric energy utilization and conservation

International Nuclear Information System (INIS)

Tripathy, S.C.

1991-01-01

Various aspects of electric energy utilization and conservation are discussed. First chapter reviews thermodynamic aspects of energy conservation. Subsequent chapters describe possibilities and methods of energy conservation in thermal power plants, airconditioning and ventilation systems, electric lighting systems, electric heating systems in industries, and railway electrification. Chapter 8 describes various modes of energy storage and compares their economies. The next chapter discusses various facets of energy economics and the last chapter discusses the practical aspects of energy conservation in different industries and power utilities. (M.G.B.). 100 refs

Testing the effectiveness of an international conservation agreement: marketplace forensics and CITES caviar trade regulation.

Science.gov (United States)

Doukakis, Phaedra; Pikitch, Ellen K; Rothschild, Anna; DeSalle, Rob; Amato, George; Kolokotronis, Sergios-Orestis

2012-01-01

The international wildlife trade is a key threat to biodiversity. Temporal genetic marketplace monitoring can determine if wildlife trade regulation efforts such as the Convention on International Trade in Endangered Species (CITES) are succeeding. Protected under CITES effective 1997, sturgeons and paddlefishes, the producers of black caviar, are flagship CITES species. We test whether CITES has limited the amount of fraudulent black caviar reaching the marketplace. Using mitochondrial DNA-based methods, we compare mislabeling in caviar and meat purchased in the New York City area pre and post CITES listing. Our recent sampling of this market reveals a decrease in mislabeled caviar (2006-2008; 10%; n = 90) compared to pre-CITES implementation (1995-1996; 19%; n = 95). Mislabeled caviar was found only in online purchase (n = 49 online/41 retail). Stricter controls on importing and exporting as per CITES policies may be having a positive conservation effect by limiting the amount of fraudulent caviar reaching the marketplace. Sturgeons and paddlefishes remain a conservation priority, however, due to continued overfishing and habitat degradation. Other marine and aquatic species stand to benefit from the international trade regulation that can result from CITES listing.

Lariat sequencing in a unicellular yeast identifies regulated alternative splicing of exons that are evolutionarily conserved with humans.

Science.gov (United States)

Awan, Ali R; Manfredo, Amanda; Pleiss, Jeffrey A

2013-07-30

Alternative splicing is a potent regulator of gene expression that vastly increases proteomic diversity in multicellular eukaryotes and is associated with organismal complexity. Although alternative splicing is widespread in vertebrates, little is known about the evolutionary origins of this process, in part because of the absence of phylogenetically conserved events that cross major eukaryotic clades. Here we describe a lariat-sequencing approach, which offers high sensitivity for detecting splicing events, and its application to the unicellular fungus, Schizosaccharomyces pombe, an organism that shares many of the hallmarks of alternative splicing in mammalian systems but for which no previous examples of exon-skipping had been demonstrated. Over 200 previously unannotated splicing events were identified, including examples of regulated alternative splicing. Remarkably, an evolutionary analysis of four of the exons identified here as subject to skipping in S. pombe reveals high sequence conservation and perfect length conservation with their homologs in scores of plants, animals, and fungi. Moreover, alternative splicing of two of these exons have been documented in multiple vertebrate organisms, making these the first demonstrations of identical alternative-splicing patterns in species that are separated by over 1 billion y of evolution.

Prospects of engineering thermotolerance in crops through modulation of heat stress transcription factor and heat shock protein networks.

Science.gov (United States)

Fragkostefanakis, Sotirios; Röth, Sascha; Schleiff, Enrico; Scharf, Klaus-Dieter

2015-09-01

Cell survival under high temperature conditions involves the activation of heat stress response (HSR), which in principle is highly conserved among different organisms, but shows remarkable complexity and unique features in plant systems. The transcriptional reprogramming at higher temperatures is controlled by the activity of the heat stress transcription factors (Hsfs). Hsfs allow the transcriptional activation of HSR genes, among which heat shock proteins (Hsps) are best characterized. Hsps belong to multigene families encoding for molecular chaperones involved in various processes including maintenance of protein homeostasis as a requisite for optimal development and survival under stress conditions. Hsfs form complex networks to activate downstream responses, but are concomitantly subjected to cell-type-dependent feedback regulation through factor-specific physical and functional interactions with chaperones belonging to Hsp90, Hsp70 and small Hsp families. There is increasing evidence that the originally assumed specialized function of Hsf/chaperone networks in the HSR turns out to be a complex central stress response system that is involved in the regulation of a broad variety of other stress responses and may also have substantial impact on various developmental processes. Understanding in detail the function of such regulatory networks is prerequisite for sustained improvement of thermotolerance in important agricultural crops. © 2014 John Wiley & Sons Ltd.

Practical results of heat conservation in a housing estate scale-actions implemented by the Pradnik-Bialy-Zachod housing cooperative in Cracow

Energy Technology Data Exchange (ETDEWEB)

Piotrowski, L. [Pradnik-Bialy-Zachod Housing Cooperative, Cracow (Poland)

1995-12-31

There are 11,600,000 apartments occupied in Poland. More than 7,700,000 of these apartments are located in towns. Energy consumption for heating, ventilation and district hot water in residential housing reaches 40% of the national power balance. A portion of district heat distribution and relatively low energy efficiency is characteristic for Polish residential housing. Seventy five percent of apartments in towns are provided with central heating installations and 55% of the entire heat demand in Polish buildings is covered by district heating systems. The total installed heat power of these systems reaches 46,000 MW. The situation with regard to conservation in Polish residential housing is directly related to the legacy of central planning of the national economy and to the current phase of its re-organization to the market-oriented system. The standard value of the overall heat-transfer coefficient for external walls in Poland until 1980 was 1.16 W/m{sup 2}K; at present it is reduced to 0.55 W/m{sup 2}K. There are numerous reasons for the low energy efficiency in residential housing. These reasons are discussed.

Geothermal electricity generation and desalination: an integrated process design to conserve latent heat with operational improvements

KAUST Repository

Missimer, Thomas M.; Ng, Kim Choon; Thuw, Kyaw; Wakil Shahzad, Muhammad

2016-01-01

A new process combination is proposed to link geothermal electricity generation with desalination. The concept involves maximizing the utilization of harvested latent heat by passing the turbine exhaust steam into a multiple effect distillation system and then into an adsorption desalination system. Processes are fully integrated to produce electricity, desalted water for consumer consumption, and make-up water for the geothermal extraction system. Further improvements in operational efficiency are achieved by adding a seawater reverse osmosis system to the site to utilize some of the generated electricity and using on-site aquifer storage and recovery to maximize water production with tailoring of seasonal capacity requirements and to meet facility maintenance requirements. The concept proposed conserves geothermally harvested latent heat and maximizes the economics of geothermal energy development. Development of a fully renewable energy electric generation-desalination-aquifer storage campus is introduced within the framework of geothermal energy development. © 2016 The Author(s). Published by Taylor & Francis

Geothermal electricity generation and desalination: an integrated process design to conserve latent heat with operational improvements

KAUST Repository

Missimer, Thomas M.

2016-02-05

A new process combination is proposed to link geothermal electricity generation with desalination. The concept involves maximizing the utilization of harvested latent heat by passing the turbine exhaust steam into a multiple effect distillation system and then into an adsorption desalination system. Processes are fully integrated to produce electricity, desalted water for consumer consumption, and make-up water for the geothermal extraction system. Further improvements in operational efficiency are achieved by adding a seawater reverse osmosis system to the site to utilize some of the generated electricity and using on-site aquifer storage and recovery to maximize water production with tailoring of seasonal capacity requirements and to meet facility maintenance requirements. The concept proposed conserves geothermally harvested latent heat and maximizes the economics of geothermal energy development. Development of a fully renewable energy electric generation-desalination-aquifer storage campus is introduced within the framework of geothermal energy development. © 2016 The Author(s). Published by Taylor & Francis

New pre-heating system for natural gas pressure regulating stations

International Nuclear Information System (INIS)

Zullo, G.; Vertuani, C.; Borghesani, O.; Vignoli, F.

1999-01-01

Costs for running natural gas pressure regulating stations are mainly due to operation and maintenance of a natural gas preheating system, usually equipment with a hot water boiler or an armour-plated electric resistance immersed in a fluid. The article describe a system, considering a natural circulation boiler which uses steam/condensate (at 100 degrees C and 0,5 bar) as a thermal conductor, in thermodynamic balance and in absence of un condensable. This new boiler, already operating with satisfactory results in heating system for industrial buildings, does not require testing, notifications, periodical inspections by the competent authorities, constant monitoring by trained or patented staff. Besides, it allows easier installations procedures and running cost savings. The system, to be considered as static because it has no moving parts, is a good alternative to conventional forced hot water circulation or electric heating system [it

Identification of two evolutionarily conserved 5' cis-elements involved in regulating spatiotemporal expression of Nolz-1 during mouse embryogenesis.

Directory of Open Access Journals (Sweden)

Sunny Li-Yun Chang

Full Text Available Proper development of vertebrate embryos depends not only on the crucial funtions of key evolutionarily conserved transcriptional regulators, but also on the precisely spatiotemporal expression of these transcriptional regulators. The mouse Nolz-1/Znf503/Zfp503 gene is a mammalian member of the conserved zinc-finger containing NET family. The expression pattern of Nolz-1 in mouse embryos is highly correlated with that of its homologues in different species. To study the spatiotemporal regulation of Nolz-1, we first identified two evolutionarily conserved cis-elements, UREA and UREB, in 5' upstream regions of mouse Nolz-1 locus. We then generated UREA-LacZ and UREB-LacZ transgenic reporter mice to characterize the putative enhancer activity of UREA and UREB. The results indicated that both UREA and UREB contained tissue-specific enhancer activity for directing LacZ expression in selective tissue organs during mouse embryogensis. UREA directed LacZ expression preferentially in selective regions of developing central nervous system, including the forebrain, hindbrain and spinal cord, whereas UREB directed LacZ expression mainly in other developing tissue organs such as the Nolz-1 expressing branchial arches and its derivatives, the apical ectodermal ridge of limb buds and the urogenital tissues. Both UREA and UREB directed strong LacZ expression in the lateral plate mesoderm where endogenous Nolz-1 was also expressed. Despite that the LacZ expression pattern did not full recapitulated the endogenous Nolz-1 expression and some mismatched expression patterns were observed, co-expression of LacZ and Nolz-1 did occur in many cells of selective tissue organs, such as in the ventrolateral cortex and ventral spinal cord of UREA-LacZ embryos, and the urogenital tubes of UREB-LacZ embryos. Taken together, our study suggests that UREA and UREB may function as evolutionarily conserved cis-regulatory elements that coordinate with other cis-elements to regulate

Twin cities institutional issues study cogenerated hot water district heating

Energy Technology Data Exchange (ETDEWEB)

Sundberg, R. E.; Leas, R.; Kolb, J. O.

1979-01-01

Community district heating, utilizing hot water produced through electrical/thermal cogeneration, is seen as an integral part of Minnesota's Energy Policy and Conservation Plan. Several studies have been conducted which consider the technical and institutional issues affecting implementation of cogenerated district heating in the Minneapolis and St. Paul Metropolitan Area. The state of the technical art of cogenerated hot water district heating is assumed to be transferable from European experience. Institutional questions relating to such factors as the form of ownership, financing, operation, regulation, and product marketability cannot be transferred from the European experience, and have been the subject of an extensive investigation. The form and function of the Institutional Issues Study, and some of the preliminary conclusions and recommendations resulting from the study are discussed.

Distinct Skeletal Muscle Gene Regulation from Active Contraction, Passive Vibration, and Whole Body Heat Stress in Humans.

Science.gov (United States)

Petrie, Michael A; Kimball, Amy L; McHenry, Colleen L; Suneja, Manish; Yen, Chu-Ling; Sharma, Arpit; Shields, Richard K

2016-01-01

Skeletal muscle exercise regulates several important metabolic genes in humans. We know little about the effects of environmental stress (heat) and mechanical stress (vibration) on skeletal muscle. Passive mechanical stress or systemic heat stress are often used in combination with many active exercise programs. We designed a method to deliver a vibration stress and systemic heat stress to compare the effects with active skeletal muscle contraction. The purpose of this study is to examine whether active mechanical stress (muscle contraction), passive mechanical stress (vibration), or systemic whole body heat stress regulates key gene signatures associated with muscle metabolism, hypertrophy/atrophy, and inflammation/repair. Eleven subjects, six able-bodied and five with chronic spinal cord injury (SCI) participated in the study. The six able-bodied subjects sat in a heat stress chamber for 30 minutes. Five subjects with SCI received a single dose of limb-segment vibration or a dose of repetitive electrically induced muscle contractions. Three hours after the completion of each stress, we performed a muscle biopsy (vastus lateralis or soleus) to analyze mRNA gene expression. We discovered repetitive active muscle contractions up regulated metabolic transcription factors NR4A3 (12.45 fold), PGC-1α (5.46 fold), and ABRA (5.98 fold); and repressed MSTN (0.56 fold). Heat stress repressed PGC-1α (0.74 fold change; p muscle contraction. Vibration induced FOXK2 (p muscle contractions. Understanding these responses may assist in developing regenerative rehabilitation interventions to improve muscle cell development, growth, and repair.

Visible cost - invisible profit. The heating, ventilation and sanitary sector and the realization of energy conservation. Among politics, knowledge and practice

International Nuclear Information System (INIS)

Hubak, Marit

1998-01-01

In social research, technology has customarily been considered problem-generating. What is needed to turn new technology into a positive instrument in environmental work? To answer this question one must understand the interaction between politics, knowledge and practice that is important for dealing with the environmental challenges. It is a main objective of this book to contribute to this understanding by analysing how the building industry deals with the energy and environmental challenges that are commonly known as energy conservation. Specifically, the book deals with the heating, ventilation and sanitary sector since this is where most of the companies working with energy conservation are found. The discussion applies to Norway

43 CFR 427.1 - Water conservation.

Science.gov (United States)

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Water conservation. 427.1 Section 427.1... INTERIOR WATER CONSERVATION RULES AND REGULATIONS § 427.1 Water conservation. (a) In general. The Secretary shall encourage the full consideration and incorporation of prudent and responsible water conservation...

Structural and functional conservation of CLEC-2 with the species-specific regulation of transcript expression in evolution.

Science.gov (United States)

Wang, Lan; Ren, Shifang; Zhu, Haiyan; Zhang, Dongmei; Hao, Yuqing; Ruan, Yuanyuan; Zhou, Lei; Lee, Chiayu; Qiu, Lin; Yun, Xiaojing; Xie, Jianhui

2012-08-01

CLEC-2 was first identified by sequence similarity to C-type lectin-like molecules with immune functions and has been reported as a receptor for the platelet-aggregating snake venom toxin rhodocytin and the endogenous sialoglycoprotein podoplanin. Recent researches indicate that CLEC-2-deficient mice were lethal at the embryonic stage associated with disorganized and blood-filled lymphatic vessels and severe edema. In view of a necessary role of CLEC-2 in the individual development, it is of interest to investigate its phylogenetic homology and highly conserved functional regions. In this work, we reported that CLEC-2 from different species holds with an extraordinary conservation by sequence alignment and phylogenetic tree analysis. The functional structures including N-linked oligosaccharide sites and ligand-binding domain implement a structural and functional conservation in a variety of species. The glycosylation sites (N120 and N134) are necessary for the surface expression CLEC-2. CLEC-2 from different species possesses the binding activity of mouse podoplanin. Nevertheless, the expression of CLEC-2 is regulated with a species-specific manner. The alternative splicing of pre-mRNA, a regulatory mechanism of gene expression, and the binding sites on promoter for several key transcription factors vary between different species. Therefore, CLEC-2 shares high sequence homology and functional identity. However the transcript expression might be tightly regulated by different mechanisms in evolution.

Global transcriptome analysis of the heat shock response ofshewanella oneidensis

Energy Technology Data Exchange (ETDEWEB)

Gao, Haichun; Wang, Sarah; Liu, Xueduan; Yan, Tinfeng; Wu, Liyou; Alm, Eric; Arkin, Adam P.; Thompson, Dorothea K.; Zhou, Jizhong

2004-04-30

Shewanella oneidensis is an important model organism for bioremediation studies because of its diverse respiratory capabilities. However, the genetic basis and regulatory mechanisms underlying the ability of S. oneidensis to survive and adapt to various environmentally relevant stresses is poorly understood. To define this organism's molecular response to elevated growth temperatures, temporal gene expression profiles were examined in cells subjected to heat stress using whole-genome DNA microarrays for S. oneidensis MR-1. Approximately 15 percent (711) of the predicted S. oneidensis genes represented on the microarray were significantly up- or down-regulated (P < 0.05) over a 25-min period following shift to the heat shock temperature (42 C). As expected, the majority of S. oneidensis genes exhibiting homology to known chaperones and heat shock proteins (Hsps) were highly and transiently induced. In addition, a number of predicted genes encoding enzymes in glycolys is and the pentose cycle, [NiFe] dehydrogenase, serine proteases, transcriptional regulators (MerR, LysR, and TetR families), histidine kinases, and hypothetical proteins were induced in response to heat stress. Genes encoding membrane proteins were differentially expressed, suggesting that cells possibly alter their membrane composition or structure in response to variations in growth temperature. A substantial number of the genes encoding ribosomal proteins displayed down-regulated co-expression patterns in response to heat stress, as did genes encoding prophage and flagellar proteins. Finally, based on computational comparative analysis of the upstream promoter regions of S.oneidensis heat-inducible genes, a putative regulatory motif, showing high conservation to the Escherichia coli sigma 32-binding consensus sequence, was identified.

Underground nuclear power station using self-regulating heat-pipe controlled reactors

International Nuclear Information System (INIS)

Hampel, V.E.

1989-01-01

The author presents a nuclear reactor for generating electricity disposed underground at the bottom of a vertical hole that can be drilled using conventional drilling technology. The primary coolant of the reactor core is the working fluid in a plurality of thermodynamically coupled heat pipes emplaced in the hole between the heat source at the bottom of the hole and heat exchange means near the surface of the earth. Additionally, the primary coolant (consisting of the working fluid in the heat pipes in the reactor core) moderates neutrons and regulates their reactivity, thus keeping the power of the reactor substantially constant. At the end of its useful life, the reactor core may be abandoned in place. Isolation from the atmosphere in case of accident or for abandonment is provided by the operation of explosive closures and mechanical valves emplaced along the hole. This invention combines technology developed and tested for small, highly efficient, space-based nuclear electric power plants with the technology of fast-acting closure mechanisms developed and used for underground testing of nuclear weapons. This invention provides a nuclear power installation which is safe from the worst conceivable reactor accident, namely, the explosion of a nuclear weapon near the ground surface of a nuclear power reactor

Underground nuclear power station using self-regulating heat-pipe controlled reactors

Science.gov (United States)

Hampel, Viktor E.

1989-01-01

A nuclear reactor for generating electricity is disposed underground at the bottom of a vertical hole that can be drilled using conventional drilling technology. The primary coolant of the reactor core is the working fluid in a plurality of thermodynamically coupled heat pipes emplaced in the hole between the heat source at the bottom of the hole and heat exchange means near the surface of the earth. Additionally, the primary coolant (consisting of the working flud in the heat pipes in the reactor core) moderates neutrons and regulates their reactivity, thus keeping the power of the reactor substantially constant. At the end of its useful life, the reactor core may be abandoned in place. Isolation from the atmosphere in case of accident or for abandonment is provided by the operation of explosive closures and mechanical valves emplaced along the hole. This invention combines technology developed and tested for small, highly efficient, space-based nuclear electric power plants with the technology of fast-acting closure mechanisms developed and used for underground testing of nuclear weapons. This invention provides a nuclear power installation which is safe from the worst conceivable reactor accident, namely, the explosion of a nuclear weapon near the ground surface of a nuclear power reactor.

Testing the effectiveness of an international conservation agreement: marketplace forensics and CITES caviar trade regulation.

Directory of Open Access Journals (Sweden)

Phaedra Doukakis

Full Text Available BACKGROUND: The international wildlife trade is a key threat to biodiversity. Temporal genetic marketplace monitoring can determine if wildlife trade regulation efforts such as the Convention on International Trade in Endangered Species (CITES are succeeding. Protected under CITES effective 1997, sturgeons and paddlefishes, the producers of black caviar, are flagship CITES species. METHODOLOGY/PRINCIPAL FINDINGS: We test whether CITES has limited the amount of fraudulent black caviar reaching the marketplace. Using mitochondrial DNA-based methods, we compare mislabeling in caviar and meat purchased in the New York City area pre and post CITES listing. Our recent sampling of this market reveals a decrease in mislabeled caviar (2006-2008; 10%; n = 90 compared to pre-CITES implementation (1995-1996; 19%; n = 95. Mislabeled caviar was found only in online purchase (n = 49 online/41 retail. CONCLUSIONS/SIGNIFICANCE: Stricter controls on importing and exporting as per CITES policies may be having a positive conservation effect by limiting the amount of fraudulent caviar reaching the marketplace. Sturgeons and paddlefishes remain a conservation priority, however, due to continued overfishing and habitat degradation. Other marine and aquatic species stand to benefit from the international trade regulation that can result from CITES listing.

WAYS TO MANAGE HEATING INERTIA

Directory of Open Access Journals (Sweden)

E. V. Biloshytskyi

2017-08-01

Full Text Available Purpose. The research paper proposes to estimate the effect of heat inertia of the water heating system, in transient operation modes, on the temperature condition in the passenger car, as well as to offer technical solutions intended to reduce the heating system inertia effect and to maintain a stable temperature condition in the passenger car premises in transitional modes of the heating system. Methodology. The author developed the method for controlling the heat transfer of heating system pipes with the help of regulating casing. To control the heating system and the heat transfer of heating pipes, two types of temperature control sensors were used in the passenger car: certain sensors interacted with regulatory casings, while the others interacted with high-voltage tubular heating element control devices. To assess the efficiency of heat interchange regulation of heating pipes and the heating system control, with installed regulating casings, the operation of the heating system with regulating casings and two types of sensors was mathematically modelled. Mathematical modelling used the experimental test data. The results of experimental tests and mathematical modelling were compared. Findings. Currently in operated passenger cars, control of heating appliances is not constructively provided. Automatic maintenance of the set temperature in a passenger car is limited to switching on and off of high-voltage tubular heating elements. The use of regulating casings on heating pipes allows reducing the effects of heat inertia and maintaining stable thermal conditions in a passenger car, using the heating system as a heat accumulator, and also provides the opportunity to realize an individual control of air temperature in the compartment. Originality. For the first time, the paper studied the alternative ways of regulating the temperature condition in a passenger car. Using of the heating system as a heat accumulator. Practical value. The

Ventilation and air heating systems. 5. rev. and enlarged ed. Lueftung und Luftheizung

Energy Technology Data Exchange (ETDEWEB)

Ihle, C. (Bundesfachschule fuer Sanitaer-, Heizungs- und Klimatechnik, Karlsruhe (Germany))

1991-01-01

Higher demands on the air quality of flats, offices and assembly rooms make ventilation and air heating the subjects of increasing interest. Taking into account the ever more urgent need for energy conservation the book deals with all aspects of ventilation on the basis of the recent DIN standards, VDI sheets and regulations. It may be used as an instruction manual, professional reference book or as a guide to practice-oriented subject selection with a minimum of theoretical fundamentals. The book deals with ventilation and air heating systems, free ventilation, design fundamentals, exercised for ventilation and air heating systems, central and decentralized ventilation systems, practical examples, ducts and calculation of ducts, air distribution, fans, noise formation, noise pollution abatement and heat recovery. (BWI) With 472 figs., 91 tabs., 1 separate map.

A highly conserved amino acid in VP1 regulates maturation of enterovirus 71.

Directory of Open Access Journals (Sweden)

Yong-Xin Zhang

2017-09-01

Full Text Available Enterovirus 71 (EV71 is the major causative agent of hand, foot and mouth disease (HFMD in children, causing severe clinical outcomes and even death. Here, we report an important role of the highly conserved alanine residue at position 107 in the capsid protein VP1 (VP1A107 in the efficient replication of EV71. Substitutional mutations of VP1A107 significantly diminish viral growth kinetics without significant effect on viral entry, expression of viral genes and viral production. The results of mechanistic studies reveal that VP1A107 regulates the efficient cleavage of the VP0 precursor during EV71 assembly, which is required, in the next round of infection, for the transformation of the mature virion (160S into an intermediate or A-particle (135S, a key step of virus uncoating. Furthermore, the results of molecular dynamic simulations and hydrogen-bond networks analysis of VP1A107 suggest that flexibility of the VP1 BC loop or the region surrounding the VP1107 residue directly correlates with viral infectivity. It is possible that sufficient flexibility of the region surrounding the VP1107 residue favors VP0 conformational change that is required for the efficient cleavage of VP0 as well as subsequent viral uncoating and viral replication. Taken together, our data reveal the structural role of the highly conserved VP1A107 in regulating EV71 maturation. Characterization of this novel determinant of EV71 virulence would promote the study on pathogenesis of Enteroviruses.

Conservation of apple and pear juice concentrates. Synergic effect of heat and radiation

International Nuclear Information System (INIS)

Kaupert, N.L.; Lescano, H.G.; Kotliar, N.

1981-01-01

This paper aims at assessing the feasibility for conserving apple and pear-juice concentrates through the synergic action of heat and radiation. The material was packed in sterile 100-μm polyethylene bags and, after the treatment was applied, the resulting fractions were stored under room temperature (25 0 C+-1 0 C). The temperature applied to the samples before irradiation was 50 0 C during 10 minutes and the doses were 100, 200, 300 and 400 krad. For such purposes, a 60 Co 165-krad/h source was used, located in a mobile irradiator. Periodical microbiological, chemical and organoleptic controls of the food were performed on both control and on irradiated samples, with or without heat. A single alterating microorganism was isolated from all the samples, which was featured as Saccharomyces rouxii. Adopting the temperature as an application variable and the absorbed dose as a constant, the above osmophilic yeast is considerably more sensitive to radiations when it is suspended in a 50% sucrose solution, after the latter was submitted to a 50 0 C temperature treatment. It has been proved that 72.5 krad are needed to attain the reduction of a logarithmic cycle in the Saccharomyces rouxii population irradiated at room temperature, while 36 krad are needed if the sample has been previously heated to 50 0 C for 10 minutes. An attempt was made to apply the synergism of such process to the juice concentrate. Below 50 0 C associated with 400 krad gamma radiation, a total inactivation took place in the Saccharomyces rouxii during the 150 days under analysis. Colour changes were detected in the concentrate; however, the acceptability features for consumption remained at a normal value (level 5) in a hedonic scale of 7 points. (author)

Down-regulation of miR-181a can reduce heat stress damage in PBMCs of Holstein cows.

Science.gov (United States)

Chen, Kun-Lin; Fu, Yuan-Yuan; Shi, Min-Yan; Li, Hui-Xia

2016-09-01

Heat stress can weaken the immune system and even increase livestock's susceptibility to disease. MicroRNA (miR) is short non-coding RNA that functions in post-transcriptional regulation of gene expression and some phenotypes. Our recent study found that miR-181a is highly expressed in the serum of heat-stressed Holstein cows, but the potential function of miR-181a is still not clarified. In this study, peripheral blood mononuclear cells (PBMCs), isolated from Holstein cows' peripheral blood, were used to investigate the effects of miR-181a inhibitor on heat stress damage. Our results showed that significant apoptosis and oxidative damage were induced by heat stress in PBMCs. However, with apoptosis, the levels of reactive oxygen species (ROS) and content of malondialdehyde (MDA) were reduced, while the content of glutathione (GSH) and the activity of superoxide dismutase (SOD) were increased even under heat stress conditions after transfecting miR-181a inhibitors to PBMCs. Meanwhile, mRNA expression of bax and caspase-3 was significantly decreased, but mRNA expression of bcl-2 was increased in transfected PBMCs. In conclusion, our results demonstrated that down-regulation of miR-181a can reduce heat stress damage in PBMCs of Holstein cows.

Nitric oxide acts as a positive regulator to induce metamorphosis of the ascidian Herdmania momus.

Science.gov (United States)

Ueda, Nobuo; Degnan, Sandie M

2013-01-01

Marine invertebrates commonly have a biphasic life cycle in which the metamorphic transition from a pelagic larva to a benthic post-larva is mediated by the nitric oxide signalling pathway. Nitric oxide (NO) is synthesised by nitric oxide synthase (NOS), which is a client protein of the molecular chaperon heat shock protein 90 (HSP90). It is notable, then, that both NO and HSP90 have been implicated in regulating metamorphosis in marine invertebrates as diverse as urochordates, echinoderms, molluscs, annelids, and crustaceans. Specifically, the suppression of NOS activity by the application of either NOS- or HSP90-inhibiting pharmacological agents has been shown consistently to induce the initiation of metamorphosis, leading to the hypothesis that a negative regulatory role of NO is widely conserved in biphasic life cycles. Further, the induction of metamorphosis by heat-shock has been demonstrated for multiple species. Here, we investigate the regulatory role of NO in induction of metamorphosis of the solitary tropical ascidian, Herdmania momus. By coupling pharmacological treatments with analysis of HmNOS and HmHSP90 gene expression, we present compelling evidence of a positive regulatory role for NO in metamorphosis of this species, in contrast to all existing ascidian data that supports the hypothesis of NO as a conserved negative regulator of metamorphosis. The exposure of competent H. momus larvae to a NOS inhibitor or an NO donor results in an up-regulation of NOS and HSP90 genes. Heat shock of competent larvae induces metamorphosis in a temperature dependent manner, up to a thermal tolerance that approaches 35°C. Both larval/post-larval survival and the appearance of abnormal morphologies in H. momus post-larvae reflect the magnitude of up-regulation of the HSP90 gene in response to heat-shock. The demonstrated role of NO as a positive metamorphic regulator in H. momus suggests the existence of inter-specific adaptations of NO regulation in ascidian

Renewable energies heat act and government grants in Germany

International Nuclear Information System (INIS)

Nast, M.

2010-01-01

In Germany renewable energies in the heat market are promoted by the Renewable Energies Heat Act (EEWaermeG) and by government grants. Ultimately, these two instruments are not only about short-term market success, but rather about the perspectives of climate protection and resource conservation. The focus of this report is therefore on the long-term significance of the current design of government grants and EEWaermeG. We will introduce and discuss the quantitative goals and structural changes strived for as well as - on a slightly shorter time horizon - the quality assurance regulations which must accompany the steady and stable growth of renewable energies. In the process, we will elaborate in particular on heat pumps, which have recently been added to the government support programme, along with solar collectors. Some explanations regarding the structural relationships between EEWaermeG and government grants round off this contribution. (author)

Differential Regulation of Receptor Activation and Agonist Selectivity by Highly Conserved Tryptophans in the Nicotinic Acetylcholine Receptor Binding Site

OpenAIRE

Williams, Dustin K.; Stokes, Clare; Horenstein, Nicole A.; Papke, Roger L.

2009-01-01

We have shown previously that a highly conserved Tyr in the nicotinic acetylcholine receptor (nAChR) ligand-binding domain (LBD) (α7 Tyr188 or α4 Tyr195) differentially regulates the activity of acetylcholine (ACh) and the α7-selective agonist 3-(4-hydroxy,2-methoxybenzylidene)anabaseine (4OH-GTS-21) in α4β2 and α7 nAChR. In this study, we mutated two highly conserved LBD Trp residues in human α7 and α4β2 and expressed the receptors in Xenopus laevis oocytes. α7 Re...

Djhsp90s are crucial regulators during planarian regeneration and tissue homeostasis.

Science.gov (United States)

Dong, Zimei; Chu, Gengbo; Sima, Yingxu; Chen, Guangwen

2018-04-15

Heat shock protein 90 family members (HSP90s), as molecular chaperones, have conserved roles in the physiological processes of eukaryotes regulating cytoprotection, increasing host resistance and so on. However, whether HSP90s affect regeneration in animals is unclear. Planarians are emerging models for studying regeneration in vivo. Here, the roles of three hsp90 genes from planarian Dugesia japonica are investigated by WISH and RNAi. The results show that: (1) Djhsp90s expressions are induced by heat and cold shock, tissue damage and ionic liquid; (2) Djhsp90s mRNA are mainly distributed each side of the body in intact worms as well as blastemas in regenerative worms; (3) the worms show head regression, lysis, the body curling and the regeneration arrest or even failure after Djhsp90s RNAi; (4) Djhsp90s are involved in autophagy and locomotion of the body. The research results suggest that Djhsp90s are not only conserved in cytoprotection, but also involved in homeostasis maintenance and regeneration process by regulating different pathways in planarians. Copyright © 2018 Elsevier Inc. All rights reserved.

Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines

Directory of Open Access Journals (Sweden)

Govindarajan Kunde R

2011-05-01

Full Text Available Abstract Background The zebrafish is recognized as a versatile cancer and drug screening model. However, it is not known whether the estrogen-responsive genes and signaling pathways that are involved in estrogen-dependent carcinogenesis and human cancer are operating in zebrafish. In order to determine the potential of zebrafish model for estrogen-related cancer research, we investigated the molecular conservation of estrogen responses operating in both zebrafish and human cancer cell lines. Methods Microarray experiment was performed on zebrafish exposed to estrogen (17β-estradiol; a classified carcinogen and an anti-estrogen (ICI 182,780. Zebrafish estrogen-responsive genes sensitive to both estrogen and anti-estrogen were identified and validated using real-time PCR. Human homolog mapping and knowledge-based data mining were performed on zebrafish estrogen responsive genes followed by estrogen receptor binding site analysis and comparative transcriptome analysis with estrogen-responsive human cancer cell lines (MCF7, T47D and Ishikawa. Results Our transcriptome analysis captured multiple estrogen-responsive genes and signaling pathways that increased cell proliferation, promoted DNA damage and genome instability, and decreased tumor suppressing effects, suggesting a common mechanism for estrogen-induced carcinogenesis. Comparative analysis revealed a core set of conserved estrogen-responsive genes that demonstrate enrichment of estrogen receptor binding sites and cell cycle signaling pathways. Knowledge-based and network analysis led us to propose that the mechanism involving estrogen-activated estrogen receptor mediated down-regulation of human homolog HES1 followed by up-regulation cell cycle-related genes (human homologs E2F4, CDK2, CCNA, CCNB, CCNE, is highly conserved, and this mechanism may involve novel crosstalk with basal AHR. We also identified mitotic roles of polo-like kinase as a conserved signaling pathway with multiple entry

Influence of acute erythrocythemia on temperature regulation during exercise-heat stress

International Nuclear Information System (INIS)

Sawka, M.N.; Gonzalez, R.R.; Dennis, R.C.; Young, A.J.; Muza, S.R.; Martin, J.W.; Francesconi, R.P.; Pandolf, K.B.; Valeri, C.R.

1986-01-01

We studied the effects of acute erythrocythemia on temperature regulation responses during exercise in the heat. In a double blind study, 6 subjects (Ss) received a 700-ml solution of autologous red blood cells at a 60% Hct, and 3 Ss (control) received a 700-ml saline solution. All Ss attempted a Heat Stress Test (HST) two weeks prior to and 48-h post-transfusion during summer months. After 30 min of rest in a 20 0 C antechamber, the HST consisted of a 120-min exposure (two repeats of 15-min rest and 45-min treadmill walk) in a 35 0 C, 45% rh environment while euhydrated. Maximal oxygen uptake (VO 2 max) and red cell volume (RCV, 51 Cr) were measured approximately 24 h before each HST. For experimental Ss, an increase in RCV (11%, P 2 max (11%, P < 0.05) was found following transfusion, whereas, differences were not observed in the control Ss. During the HSTs for experimental Ss, metabolic rate as well as steady state rectal and esophageal temperatures were similar, but heat storage tended (P = 0.13) to be lower post-transfusion. Steady state local arm (R + C) was reduced (P < 0.05) with no change in total body sweating rate or local arm evaporative heat loss post-transfusion. For control Ss, thermoregulatory responses were generally not altered post-transfusion. Erythrocythemia may improve steady state sensible heat exchange by allowing a greater volume of blood to be directed to the cutaneous vasculature

Heat planning for fossil-fuel-free district heating areas with extensive end-use heat savings: A case study of the Copenhagen district heating area in Denmark

International Nuclear Information System (INIS)

Harrestrup, M.; Svendsen, S.

2014-01-01

The Danish government plans to make the Danish energy system to be completely free of fossil fuels by 2050 and that by 2035 the energy supply for buildings and electricity should be entirely based on renewable energy sources. To become independent from fossil fuels, it is necessary to reduce the energy consumption of the existing building stock, increase energy efficiency, and convert the present heat supply from fossil fuels to renewable energy sources. District heating is a sustainable way of providing space heating and domestic hot water to buildings in densely populated areas. This paper is a theoretical investigation of the district heating system in the Copenhagen area, in which heat conservation is related to the heat supply in buildings from an economic perspective. Supplying the existing building stock from low-temperature energy resources, e.g. geothermal heat, might lead to oversized heating plants that are too expensive to build in comparison with the potential energy savings in buildings. Long-term strategies for the existing building stock must ensure that costs are minimized and that investments in energy savings and new heating capacity are optimized and carried out at the right time. - Highlights: • We investigate how much heating consumption needs to be reduced in a district heating area. • We examine fossil-fuel-free supply vs. energy conservations in the building stock. • It is slightly cost-beneficial to invest in energy renovation from today for a societal point of view. • It is economically beneficial for district heating companies to invest in energy renovations from today. • The cost per delivered heat unit is lower when energy renovations are carried out from today

Regulation of fruit and seed response to heat and drought by sugars as nutrients and signals

Directory of Open Access Journals (Sweden)

Yong-Hua eLiu

2013-08-01

Full Text Available A large body of evidence shows that sugars function both as nutrients and signals to regulate fruit and seed set under normal and stress conditions including heat and drought. Inadequate sucrose import to, and its degradation within, reproductive organs cause fruit and seed abortion under heat and drought. As nutrients, sucrose-derived hexoses provide carbon skeletons and energy for growth and development of fruits and seeds. Sugar metabolism can also alleviate the impact of stress on fruit and seed through facilitating biosynthesis of heat shock proteins (Hsps and non-enzymic antioxidants (e.g. glutathione, ascorbic acid, which collectively maintain the integrity of membranes and prevent programmed cell death (PCD through protecting proteins and scavenging reactive oxygen species (ROS. In parallel, sugars (sucrose, glucose and fructose, also exert signalling roles through cross-talk with hormone and ROS signalling pathways and by mediating cell division and PCD. At the same time, emerging data indicate that sugar-derived signalling systems, including trehalose-6 phosphate (T6P, sucrose non-fermenting related kinase-1 (SnRK and the target of rapamycin (TOR kinase complex also play important roles in regulating plant development through modulating nutrient and energy signalling and metabolic processes, especially under abiotic stresses where sugar availability is low. This review aims to evaluate recent progress of research on abiotic stress responses of reproductive organs focusing on roles of sugar metabolism and signalling and addressing the possible biochemical and molecular mechanism by which sugars regulate fruit and seed set under heat and drought.

Life cycle study. Carbon dioxide emissions lower in electric heating than in oil heating

Energy Technology Data Exchange (ETDEWEB)

Heikkinen, A.; Jaervinen, P.; Nikula, A.

1996-11-01

A primary objective of energy conservation is to cut carbon dioxide emissions. A comparative study on the various heating forms, based on the life cycle approach, showed that the carbon dioxide emissions resulting form heating are appreciably lower now that electric heating has become more common. The level of carbon dioxide emissions in Finland would have been millions of tonnes higher had oil heating been chosen instead of electric heating. (orig.)

Functional analysis of the conserved transcriptional regulator CfWor1 in Cladosporium fulvum reveals diverse roles in the virulence of plant pathogenic fungi

NARCIS (Netherlands)

Ökmen, B.; Collemare, J.; Griffiths, S.A.; Burgt, van der A.; Cox, R.; Wit, de P.J.G.M.

2014-01-01

Fungal Wor1-like proteins are conserved transcriptional regulators that are reported to regulate the virulence of several plant pathogenic fungi by affecting the expression of virulence genes. Here, we report the functional analysis of CfWor1, the homologue of Wor1 in Cladosporium fulvum. ¿cfwor1

Actual energy consumption in dwellings. The effect of energy performance regulations and occupant behaviour

Energy Technology Data Exchange (ETDEWEB)

Guerra Santin, O.

2010-10-19

Residential buildings have continuously improved in energy efficiency, partly as a consequence of the introduction of energy regulations in many countries. Although better thermal properties and systems efficiency have lowered energy consumption for space heating in recent decades, substantial differences in energy consumption in similar dwellings are still being observed. These differences in consumption are thought to be caused by differences in occupancy patterns, by quality of construction and by rebound effects. This research addresses the effect of energy performance regulations and occupant behavior on energy consumption for space and water heating in dwellings built after the introduction of the energy performance regulations in the Netherlands. The results of this research show that improving the energy efficiency of buildings alone is not enough to decrease that energy consumption. The large differences found in the use of dwellings indicate that, especially in energy efficient houses, occupant behavior provides an opportunity for further reductions in the energy consumption for space heating which could boost the efforts to conserve energy worldwide.

An underground nuclear power station using self-regulating heat-pipe controlled reactors

Science.gov (United States)

Hampel, V.E.

1988-05-17

A nuclear reactor for generating electricity is disposed underground at the bottom of a vertical hole that can be drilled using conventional drilling technology. The primary coolant of the reactor core is the working fluid in a plurality of thermodynamically coupled heat pipes emplaced in the hole between the heat source at the bottom of the hole and heat exchange means near the surface of the earth. Additionally, the primary coolant (consisting of the working fluid in the heat pipes in the reactor core) moderates neutrons and regulates their reactivity, thus keeping the power of the reactor substantially constant. At the end of its useful life, the reactor core may be abandoned in place. Isolation from the atmosphere in case of accident or for abandonment is provided by the operation of explosive closures and mechanical valves emplaced along the hole. This invention combines technology developed and tested for small, highly efficient, space-based nuclear electric power plants with the technology of fast- acting closure mechanisms developed and used for underground testing of nuclear weapons. This invention provides a nuclear power installation which is safe from the worst conceivable reactor accident, namely, the explosion of a nuclear weapon near the ground surface of a nuclear power reactor. 5 figs.

Making Heat Visible

Science.gov (United States)

Goodhew, Julie; Pahl, Sabine; Auburn, Tim; Goodhew, Steve

2015-01-01

Householders play a role in energy conservation through the decisions they make about purchases and installations such as insulation, and through their habitual behavior. The present U.K. study investigated the effect of thermal imaging technology on energy conservation, by measuring the behavioral effect after householders viewed images of heat escaping from or cold air entering their homes. In Study 1 (n = 43), householders who received a thermal image reduced their energy use at a 1-year follow-up, whereas householders who received a carbon footprint audit and a non-intervention control demonstrated no change. In Study 2 (n = 87), householders were nearly 5 times more likely to install draught proofing measures after seeing a thermal image. The effect was especially pronounced for actions that addressed an issue visible in the images. Findings indicate that using thermal imaging to make heat loss visible can promote energy conservation. PMID:26635418

Energy conservation according to the building codes of the National Board of Housing, Building and Planning; Energihushaallning enligt Boverkets byggregler

Energy Technology Data Exchange (ETDEWEB)

2009-10-15

To comply with international and national targets for energy use, the National Board has adopted rules setting the levels to be met in order to conserve energy in buildings. The rules for buildings are shown in Boverkets building regulations (BBR). The BBR lists comprehensive requirements in order to ensure that a building must not use more than a certain number of kilowatt hours per square meter and year. There are more detailed requirements for thermal insulation, heating, cooling and air conditioning installations, efficient use of electricity and installation of metering systems for monitoring of building energy. The latest version of the BBR came into force on February 1, 2009 and has more stringent requirements for the buildings heated by electricity or comfort cooling powered by electricity. This handbook presents comments and answers to questions about the new rules for energy conservation. It replaces our previous handbook 'Thermal calculations'

Heat planning for fossil-fuel-free district heating areas with extensive end-use heat savings

DEFF Research Database (Denmark)

Harrestrup, Maria; Svendsen, S.

2014-01-01

is a theoretical investigation of the district heating system in the Copenhagen area, in which heat conservation is related to the heat supply in buildings from an economic perspective. Supplying the existing building stock from low-temperature energy resources, e.g. geothermal heat, might lead to oversized......The Danish government plans to make the Danish energy system to be completely free of fossil fuels by 2050 and that by 2035 the energy supply for buildings and electricity should be entirely based on renewable energy sources. To become independent from fossil fuels, it is necessary to reduce...... the energy consumption of the existing building stock, increase energy efficiency, and convert the present heat supply from fossil fuels to renewable energy sources. District heating is a sustainable way of providing space heating and domestic hot water to buildings in densely populated areas. This paper...

Hypoxia-inducible factor 1 regulates heat and cold pain sensitivity and persistence.

Science.gov (United States)

Kanngiesser, Maike; Mair, Norbert; Lim, Hee-Young; Zschiebsch, Katja; Blees, Johanna; Häussler, Annett; Brüne, Bernhard; Ferreiròs, Nerea; Kress, Michaela; Tegeder, Irmgard

2014-06-01

The present study assessed the functions of the transcription factor hypoxia-inducible factor (HIF) in sensory neurons in models of acute, inflammatory, ischemic, and neuropathic pain. The alpha subunit, HIF1α, was specifically deleted in neurons of the dorsal root ganglia by mating HIF1α(fl/fl) mice with SNScre mice. SNS-HIF1α(-/-) mice were more sensitive to noxious heat and cold pain stimulation than were HIF1α(fl/fl) control mice. They also showed heightened first-phase nociceptive responses in the formalin and capsaicin tests with increased numbers of cFos-positive neurons in the dorsal horn, and intensified hyperalgesia in early phases after paw inflammation and hind limb ischemia/reperfusion. The behavioral cold and heat pain hypersensitivity was explained by increased calcium fluxes after transient receptor potential channel activation in primary sensory neurons of SNS-HIF1α(-/-) mice and lowered electrical activation thresholds of sensory fibers. SNS-HIF1α(-/-) mice however, developed less neuropathic pain after sciatic nerve injury, which was associated with an abrogation of HIF1-mediated gene up-regulation. The results suggest that HIF1α is protective in terms of acute heat and cold pain but in case of ongoing activation in injured neurons, it may promote the development of neuropathic pain. The duality of HIF1 in pain regulation may have an impact on the side effects of drugs targeting HIF1, which are being developed, for example, as anticancer agents. Specifically, in patients with cancer neuropathy, however, temporary HIF1 inhibition might provide a welcome combination of growth and pain reduction.

Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development.

Directory of Open Access Journals (Sweden)

Sushma Grellscheid

2011-12-01

Full Text Available Alternative splicing amplifies the information content of the genome, creating multiple mRNA isoforms from single genes. The evolutionarily conserved splicing activator Tra2β (Sfrs10 is essential for mouse embryogenesis and implicated in spermatogenesis. Here we find that Tra2β is up-regulated as the mitotic stem cell containing population of male germ cells differentiate into meiotic and post-meiotic cells. Using CLIP coupled to deep sequencing, we found that Tra2β binds a high frequency of exons and identified specific G/A rich motifs as frequent targets. Significantly, for the first time we have analysed the splicing effect of Sfrs10 depletion in vivo by generating a conditional neuronal-specific Sfrs10 knock-out mouse (Sfrs10(fl/fl; Nestin-Cre(tg/+. This mouse has defects in brain development and allowed correlation of genuine physiologically Tra2β regulated exons. These belonged to a novel class which were longer than average size and importantly needed multiple cooperative Tra2β binding sites for efficient splicing activation, thus explaining the observed splicing defects in the knockout mice. Regulated exons included a cassette exon which produces a meiotic isoform of the Nasp histone chaperone that helps monitor DNA double-strand breaks. We also found a previously uncharacterised poison exon identifying a new pathway of feedback control between vertebrate Tra2 proteins. Both Nasp-T and the Tra2a poison exon are evolutionarily conserved, suggesting they might control fundamental developmental processes. Tra2β protein isoforms lacking the RRM were able to activate specific target exons indicating an additional functional role as a splicing co-activator. Significantly the N-terminal RS1 domain conserved between flies and humans was essential for the splicing activator function of Tra2β. Versions of Tra2β lacking this N-terminal RS1 domain potently repressed the same target exons activated by full-length Tra2β protein.

Retrofit energy conservation in residential buildings in southern California

Science.gov (United States)

Turner, R. H.; Birur, G. C.; Daksla, C.

1982-01-01

The common energy conservation techniques (ECTs) that can be retrofit-installed into residential buildings are surveyed. The quantity of saved energy for heating and cooling attributable to each ECT is evaluated for three common modes of heating: natural gas heating at 60/therm; heating via heat pump at $1.20/therm; and electric resistance heating at $2.40/therm. In every case, a life cycle cost comparison is made between the long term revenue due to energy conservation and a safe and conventional alternative investment that might be available to the prudent homeowner. The comparison between investment in an ECT and the alternative investment is brought into perspective using the life cycle payback period and an economic Figure of Merit (FOM). The FOM allows for relative ranking between candidate ECTs. Because the entire spectrum of winter heating climates in California is surveyed, the decision maker can determine whether or not a considered ECT is recommended in a given climate, and under what conditions an ECT investment becomes attractive.

Low-temperature waste-heat recovery in the food and paper industries

Energy Technology Data Exchange (ETDEWEB)

Foell, W.K.; Lund, D.; Mitchell, J.W.; Ray, D.; Stevenson, R.; TenWolde, A.

1980-11-01

The potential of low-temperature waste-heat recovery technology is examined. An examination of barriers to impede waste-heat recovery is made and research programs are identified. Extensive information and data are presented in the following chapters: Waste Heat Recovery in the Wisconsin Food Industry; Waste Heat Recovery in the Wisconsin Pulp and Paper Industry; Industries' Economic Analysis of Energy Conservation Projects; Industrial Waste Heat Recovery (selection of heat-recovery heat exchangers for industrial applications, simplified procedure for selection of heat recovery heat exchangers for industrial applications, selection of heat pumps for industrial applications); Institutional Aspects of Industrial Energy Conservation (economic motivation for energy conservation and the industrial response, intrafirm idea channels and their sources, evaluation and approval of plant improvement projects, reported barriers to adopting waste heat recovery projects and recommendations for government involvement, and the final chapter is a summary with major conclusions given. Additional information is given in two appendices on the potential waste heat recovery in a cheese plant (calculation) and conditions for optimum exchanger size and break-even fuel cost. (MCW)

RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response.

Directory of Open Access Journals (Sweden)

Roelien A M Meijering

Full Text Available The heat shock response (HSR is an ancient and highly conserved program of stress-induced gene expression, aimed at reestablishing protein homeostasis to preserve cellular fitness. Cells that fail to activate or maintain this protective response are hypersensitive to proteotoxic stress. The HSR is mediated by the heat shock transcription factor 1 (HSF1, which binds to conserved heat shock elements (HSE in the promoter region of heat shock genes, resulting in the expression of heat shock proteins (HSP. Recently, we observed that hyperactivation of RhoA conditions cardiomyocytes for the cardiac arrhythmia atrial fibrillation. Also, the HSR is annihilated in atrial fibrillation, and induction of HSR mitigates sensitization of cells to this disease. Therefore, we hypothesized active RhoA to suppress the HSR resulting in sensitization of cells for proteotoxic stimuli.Stimulation of RhoA activity significantly suppressed the proteotoxic stress-induced HSR in HL-1 atrial cardiomyocytes as determined with a luciferase reporter construct driven by the HSF1 regulated human HSP70 (HSPA1A promoter and HSP protein expression by Western Blot analysis. Inversely, RhoA inhibition boosted the proteotoxic stress-induced HSR. While active RhoA did not preclude HSF1 nuclear accumulation, phosphorylation, acetylation, or sumoylation, it did impair binding of HSF1 to the hsp genes promoter element HSE. Impaired binding results in suppression of HSP expression and sensitized cells to proteotoxic stress.These results reveal that active RhoA negatively regulates the HSR via attenuation of the HSF1-HSE binding and thus may play a role in sensitizing cells to proteotoxic stimuli.

Solar Energy: Heat Storage.

Science.gov (United States)

Knapp, Henry H., III

This module on heat storage is one of six in a series intended for use as supplements to currently available materials on solar energy and energy conservation. Together with the recommended texts and references (sources are identified), these modules provide an effective introduction to energy conservation and solar energy technologies. The module…

A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans.

Science.gov (United States)

Walker, Amy K; Jacobs, René L; Watts, Jennifer L; Rottiers, Veerle; Jiang, Karen; Finnegan, Deirdre M; Shioda, Toshi; Hansen, Malene; Yang, Fajun; Niebergall, Lorissa J; Vance, Dennis E; Tzoneva, Monika; Hart, Anne C; Näär, Anders M

2011-11-11

Sterol regulatory element-binding proteins (SREBPs) activate genes involved in the synthesis and trafficking of cholesterol and other lipids and are critical for maintaining lipid homeostasis. Aberrant SREBP activity, however, can contribute to obesity, fatty liver disease, and insulin resistance, hallmarks of metabolic syndrome. Our studies identify a conserved regulatory circuit in which SREBP-1 controls genes in the one-carbon cycle, which produces the methyl donor S-adenosylmethionine (SAMe). Methylation is critical for the synthesis of phosphatidylcholine (PC), a major membrane component, and we find that blocking SAMe or PC synthesis in C. elegans, mouse liver, and human cells causes elevated SREBP-1-dependent transcription and lipid droplet accumulation. Distinct from negative regulation of SREBP-2 by cholesterol, our data suggest a feedback mechanism whereby maturation of nuclear, transcriptionally active SREBP-1 is controlled by levels of PC. Thus, nutritional or genetic conditions limiting SAMe or PC production may activate SREBP-1, contributing to human metabolic disorders. Copyright © 2011 Elsevier Inc. All rights reserved.

Analysis of heat transfer regulation and modification employing intermittently emplaced porous cavities

International Nuclear Information System (INIS)

Vafai, K.; Huang, P.C.

1994-01-01

The present work forms a fundamental investigation on the effects of using intermittently porous cavities for regulating and modifying the flow and temperature fields and therefore changing the skin friction and heat transfer characteristics of an external surface. A general flow model that accounts for the effects of the impermeable boundary and inertial effects is used to describe the flow inside the porous region. Solutions of the problem have been carried out using a finite-difference method through the use of a stream function-vorticity transformation. Various interesting characteristics of the flow and temperature fields in the composite layer are analyzed and discussed in detail. The effects of various governing dimensionless parameters, such as the Darcy number, Reynolds number, Prandtl number, the inertia parameter as well as the effects of pertinent geometric parameters are thoroughly explored. Furthermore, the interactive effects of the embedded porous substrates on skin friction and heat transfer characteristics of an external surface are analyzed. The configuration analyzed in this work provides an innovative approach in altering the frictional and heat transfer characteristics of an external surface. 27 refs., 12 figs., 1 tab

Implications Of Fuelwood Demandon Sustainable Forest Conservation Of The Sub-Sahara Africa

Directory of Open Access Journals (Sweden)

Sogbon Odunwole

2017-04-01

Full Text Available Forests contribute immensely to economic and social development through formal trade in timber environmental services non- timber forest products safety net spiritual and aesthetic value. Wood is a key source of energy that has been used for millennia for cooking boiling water lighting and heating. Today about 2.5billion people depend on biomass energy for cooking and heating with 87 of this energy being provided by wood. In sub-Saharan African more than 90 of the population relies on wood fire that is firewood and charcoal as their primary source of domestic energy. Over 80 of urban householders and small industries use charcoal and firewood as their source of energy. Despite their numerous importance Africas forest continue to decline rapidly due to increase in agricultural practices into forest lands population growth and urbanization increased poverty high dependence on natural resources for subsistence and income through forest. The study centred on the implications of fuel wood demand on forest conservation in sub-Sahara Africa - a regional focus on Akure metropolitan area Ondo State. The specific objectives of the paper were to identify firewood consumption pattern in Akure metropolitan area and factors responsible for increased fuelwood demand in the study area. The paper adopted direct observation oral interview and 0.05 of the study area as sample size for the study. The study observed lack of adequate alternative poor implementation and enforcement of government regulation on forestry poverty and poor awareness on the menace of forest depletion among others. The paper posited provision of alternative fuel with subsidy regular awareness campaign proper monitoring implementation and enforcement of forest regulations with a view to achieving sustainable conservation.

The effect of building regulations and energy conservation measures in domestic sector on national energy consumption

International Nuclear Information System (INIS)

Samo, S.R.; Akhund, M.A.; Brohi, K.M.

2004-01-01

In England, housing accounts for some 30% of total fuel consumption and a similar proportion of energy-related carbon dioxide (CO/sub 2/) emission. A study has been conducted to analyse the effect of the legislations and UK thermal building regulations on national energy consumption in housing. This research paper presents data on the percentage of dwelling stock, the energy consumption, energy cost and carbon dioxide (CO/sub 2/) emission in different types of dwellings, which comply different building regulations from 1965 to 1995. It was found that. 66% of the dwelling stock, which comply the building Regulations before 1965, consumes 73% of total energy used in housing. This dwelling stock is also responsible for 75% of carbon dioxide (CO/sub 2/) emission. Whereas currently only 4% of the dwelling stock complies the latest building regulations 1995 which consume 2 % of energy and produce a similar percentage of carbon dioxide (CO/sub 2/) emission in housing. Since the large portion of the dwelling stock is comprised of old dwellings, therefore the greatest potential for energy conservation measures can be found in improving these dwellings instead of constructing new dwellings. (author)

Econometric modelling of conservation

International Nuclear Information System (INIS)

Parker, J.C.; Seal, D.J.

1990-01-01

The issue of energy conservation in general, and conservation in the natural gas markets in particular, has recently had a much lower profile than in the past, when energy prices were significantly higher and energy costs composed a much larger proportion of industrial operating costs than today. The recent downward trend in energy prices has diverted attention away from this issue. In the face of expected significant real price increases, increasing pressure from environmental groups, and directives on the part of regulator authorities, conservation is once again becoming a topic of consideration in the energy industry. From the point of view of gas demand forecasting, conservation has received too little attention. The intentions of this paper are to establish the need for forecasting conservation in the natural gas utility sector, and to construct a model of industrial demand which incorporates conservation and is appropriate for use as a forecasting tool

Expression of the stress-response regulators CtsR and HrcA in the uropathogen Staphylococcus saprophyticus during heat shock.

Science.gov (United States)

Rossi, Ciro César; de Oliveira, Lorayne Lauria; de Carvalho Rodrigues, Deivid; Ürményi, Turán Peter; Laport, Marinella Silva; Giambiagi-deMarval, Marcia

2017-08-01

The uropathogen Staphylococcus saprophyticus is an ubiquitous bacterium but little is known about mechanisms that allow its persistence in diverse environments. Here we evaluated S. saprophyticus growth and survival during heat shock, the expression of stress response regulators ctsR and hrcA through qRT-PCR and heat shock protein synthesis through 35 S-Met metabolic labeling. S. saprophyticus does not tolerate temperatures much higher than the optimal 37 °C, as its growth is greatly affected at 42 °C, though viability is maintained up to 48 °C. At 42 °C, the expression of ctsR and hrcA repressor genes approximately triple when compared to 37 °C and continue to increase together with temperature till 48 °C. Expression of hrcA peaks after 20 min of heat shock and decreases significantly after 30 min, indicating that heat stress response regulated by this gene may last 20-30 min. An increase in temperature is accompanied by the synthesis of at least eight proteins, three of which are likely the chaperones DnaK, GroEL and ClpB. In silico analysis indicate that the groEL gene may be regulated by HrcA, clpB by CtsR and dnaK by both repressors. This is the first work to discuss heat stress response in S. saprophyticus and a step forward in the understanding of mechanisms that make this a widespread and emergent pathogen.

The role of the velocity gradient in laminar convective heat transfer through a tube with a uniform wall heat flux

International Nuclear Information System (INIS)

Wang Liangbi; Zhang Qiang; Li Xiaoxia

2009-01-01

This paper aims to contribute to a better understanding of convective heat transfer. For this purpose, the reason why thermal diffusivity should be placed before the Laplacian operator of the heat flux, and the role of the velocity gradient in convective heat transfer are analysed. The background to these analyses is that, when the energy conservation equation of convective heat transfer is used to explain convective heat transfer there are two points that are difficult for teachers to explain and for undergraduates to understand: thermal diffusivity is placed before the Laplacian operator of temperature; on the wall surface (the fluid side) the velocity is zero, a diffusion equation of temperature is gained from energy conservation equation, however, temperature cannot be transported. Consequently, the real physical meaning of thermal diffusivity is not clearly reflected in the energy conservation equation, and whether heat transfer occurs through a diffusion process or a convection process on the wall surface is not clear. Through a simple convective heat transfer case: laminar convective heat transfer in a tube with a uniform wall heat flux on the tube wall, this paper explains these points more clearly. The results declare that it is easier for teachers to explain and for undergraduates to understand these points when a description of heat transfer in terms of the heat flux is used. In this description, thermal diffusivity is placed before the Laplacian operator of the heat flux; the role of the velocity gradient in convective heat transfer appears, on the wall surface, the fact whether heat transfer occurs through a diffusion process or a convection process can be explained and understood easily. The results are not only essential for teachers to improve the efficiency of university-level physics education regarding heat transfer, but they also enrich the theories for understanding heat transfer

A Conserved Splicing Silencer Dynamically Regulates O-GlcNAc Transferase Intron Retention and O-GlcNAc Homeostasis

Directory of Open Access Journals (Sweden)

Sung-Kyun Park

2017-08-01

Full Text Available Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases. The enzymes O-GlcNAc transferase (OGT and O-GlcNAcase (OGA add and remove O-GlcNAc, but the mechanisms regulating their expression remain unclear. Here, we demonstrate that retention of the fourth intron of OGT is regulated in response to O-GlcNAc levels. We further define a conserved intronic splicing silencer (ISS that is necessary for OGT intron retention. Deletion of the ISS in colon cancer cells leads to increases in OGT, but O-GlcNAc homeostasis is maintained by concomitant increases in OGA protein. However, the ISS-deleted cells are hypersensitive to OGA inhibition in culture and in soft agar. Moreover, growth of xenograft tumors from ISS-deleted cells is compromised in mice treated with an OGA inhibitor. Thus, ISS-mediated regulation of OGT intron retention is a key component in OGT expression and maintaining O-GlcNAc homeostasis.

Utilising heat from nuclear waste for space heating

International Nuclear Information System (INIS)

Deacon, D.

1982-01-01

A heating unit utilising the decay heat from irradiated material comprises a storage envelope for the material associated with a heat exchange system, means for producing a flow of air over the heat exchange system to extract heat from the material, an exhaust duct capable of discharging the heated air to the atmosphere, and means for selectively diverting at least some of the heated air to effect the required heating. With the flow of air over the heat exchange system taking place by a natural thermosyphon process the arrangement is self regulating and inherently reliable. (author)

Energy-conserving mechanisms as adaptation to undernutrition and water deprivation in the African Zebu

International Nuclear Information System (INIS)

Finch, V.A.; King, J.M.

1982-01-01

In a study designed to simulate pastoral cattle management practices on marginal and rangelands in Kenya, the physiological adaptations for energy conservation were investigated in African Zebu cattle during a period of undernutrition and water deprivation. In experimental design, the food available to cattle was restricted to 50% of maintenance, watering reduced to every 2 d and distances walked increased from 8 to 16 km/d. Restricting food for nearly 3 months resulted in a 13-14% weight loss in cattle. A 2-day watering regime did not decrease food intake. Cattle that walked the longer distances lost slightly more weight but not significantly more. There was a significant overall reduction in water requirements. Slowing water turnover is seen as adaptive in a water-limited environment. The water turnover rate was determined using the tritiated water dilution technique. Higher solar intensities increased water turnover somewhat, as did extending walking distances. The resting metabolic rate of cattle on restricted food and water was reduced to 30% below that of well-fed and daily watered cattle. This reduction in metabolic requirements would result in conserving energy in dry seasons. Cattle became more thermolabile when offered smaller quantities of food. A heat debt was incurred at night and sweating rates were regulated at low levels during the day, resulting in heat storage. It is suggested that this is a mechanism by which energy is conserved through increasing thermogenesis to maintain body temperature within the normal range

Energy conservation in industry

International Nuclear Information System (INIS)

Pembleton, P.

1992-01-01

Energy Conservation in Industry is the first number in the Energy and Environmental Series of the Industrial and Technological Information Bank (INTIB). The Series supersedes the INECA Journal and reflects the broader information programme undertaken by INTIB. The present number of the Series contains contributions from three major international databases and five topic-specific sources, including three United Nations Organizations. The present publication consists of a recent technical report on a current topic: reducing energy loss in four industrial sectors and improving energy conservation through waste-heat recovery, followed by two sections containing abstracts of technical materials

Heat-shock proteins in stromal joint tissues: innocent bystanders or disease-initiating proteins?

Science.gov (United States)

Lambrecht, Stijn; Juchtmans, Nele; Elewaut, Dirk

2014-02-01

Heat-shock proteins (HSPs) are molecular chaperones that are highly conserved between species. In recent decades it has become clear that these proteins play an important role in the pathogenesis of inflammatory and degenerative joint diseases by (dys)regulating the immune system and by direct effects on the stromal tissues of the joint. In this review we discuss current insights into the expression pattern of HSPs in connective tissues, the direct biological role of HSPs in stromal tissues and the potential clinical applications.

What Can We Learn about Workplace Heat Stress Management from a Safety Regulator Complaints Database?

Directory of Open Access Journals (Sweden)

Alana Hansen

2018-03-01

Full Text Available Heat exposure can be a health hazard for many Australian workers in both outdoor and indoor situations. With many heat-related incidents left unreported, it is often difficult to determine the underlying causal factors. This study aims to provide insights into perceptions of potentially unsafe or uncomfortably hot working conditions that can affect occupational health and safety using information provided by the public and workers to the safety regulator in South Australia (SafeWork SA. Details of complaints regarding heat exposure to the regulator’s “Help Centre” were assembled in a dataset and the textual data analysed thematically. The findings showed that the majority of calls relate to indoor work environments such as kitchens, factories, and warehouses. The main themes identified were work environment, health effects, and organisational issues. Impacts of hot working conditions ranged from discomfort to serious heat-related illnesses. Poor management practices and inflexibility of supervisors featured strongly amongst callers’ concerns. With temperatures predicted to increase and energy prices escalating, this timely study, using naturalistic data, highlights accounts of hot working conditions that can compromise workers’ health and safety and the need for suitable measures to prevent heat stress. These could include risk assessments to assess the likelihood of heat stress in workplaces where excessively hot conditions prevail.

High intensity heat pulse problem

International Nuclear Information System (INIS)

Yalamanchili, R.

1977-01-01

The use of finite-difference methods for the solution of partial differential equations is common in both design and research and development because of the advance of computers. The numerical methods for the unsteady heat diffusion equation received most attention not only because of heat transfer problems but also happened to be the basis for any study of parabolic partial differential equations. It is common to test the heat equation first even the methods developed for complex nonlinear parabolic partial differential equations arising in fluid mechanics or convective heat transfer. It is concluded that the finite-element method is conservative in both stability and monoscillation characteristics than the finite-difference method but not as conservative as the method of weighted-residuals. Since the finite-element is unique because of Gurtin's variational principle and numerous finite-differences can be constructed, it is found that some finite-difference schemes are better than the finite-element scheme in accuracy also. Therefore, further attention is focused here on finite-difference schemes only. Various physical problems are considered in the field of heat transfer. These include: numerous problems in steady and unsteady heat conduction; heat pulse problems, such as, plasma torch; problems arising from machining operations, such as, abrasive cut-off and surface grinding. (Auth.)

Conserved upstream open reading frames in higher plants

Directory of Open Access Journals (Sweden)

Schultz Carolyn J

2008-07-01

Full Text Available Abstract Background Upstream open reading frames (uORFs can down-regulate the translation of the main open reading frame (mORF through two broad mechanisms: ribosomal stalling and reducing reinitiation efficiency. In distantly related plants, such as rice and Arabidopsis, it has been found that conserved uORFs are rare in these transcriptomes with approximately 100 loci. It is unclear how prevalent conserved uORFs are in closely related plants. Results We used a homology-based approach to identify conserved uORFs in five cereals (monocots that could potentially regulate translation. Our approach used a modified reciprocal best hit method to identify putative orthologous sequences that were then analysed by a comparative R-nomics program called uORFSCAN to find conserved uORFs. Conclusion This research identified new genes that may be controlled at the level of translation by conserved uORFs. We report that conserved uORFs are rare (

Macoilin, a conserved nervous system-specific ER membrane protein that regulates neuronal excitability.

Directory of Open Access Journals (Sweden)

Fausto Arellano-Carbajal

2011-03-01

Full Text Available Genome sequence comparisons have highlighted many novel gene families that are conserved across animal phyla but whose biological function is unknown. Here, we functionally characterize a member of one such family, the macoilins. Macoilins are characterized by several highly conserved predicted transmembrane domains towards the N-terminus and by coiled-coil regions C-terminally. They are found throughout Eumetazoa but not in other organisms. Mutants for the single Caenorhabditis elegans macoilin, maco-1, exhibit a constellation of behavioral phenotypes, including defects in aggregation, O₂ responses, and swimming. MACO-1 protein is expressed broadly and specifically in the nervous system and localizes to the rough endoplasmic reticulum; it is excluded from dendrites and axons. Apart from subtle synapse defects, nervous system development appears wild-type in maco-1 mutants. However, maco-1 animals are resistant to the cholinesterase inhibitor aldicarb and sensitive to levamisole, suggesting pre-synaptic defects. Using in vivo imaging, we show that macoilin is required to evoke Ca²(+ transients, at least in some neurons: in maco-1 mutants the O₂-sensing neuron PQR is unable to generate a Ca²(+ response to a rise in O₂. By genetically disrupting neurotransmission, we show that pre-synaptic input is not necessary for PQR to respond to O₂, indicating that the response is mediated by cell-intrinsic sensory transduction and amplification. Disrupting the sodium leak channels NCA-1/NCA-2, or the N-,P/Q,R-type voltage-gated Ca²(+ channels, also fails to disrupt Ca²(+ responses in the PQR cell body to O₂ stimuli. By contrast, mutations in egl-19, which encodes the only Caenorhabditis elegans L-type voltage-gated Ca²(+ channel α1 subunit, recapitulate the Ca²(+ response defect we see in maco-1 mutants, although we do not see defects in localization of EGL-19. Together, our data suggest that macoilin acts in the ER to regulate assembly or

Evolutionary Conservation of the Components in the TOR Signaling Pathways.

Science.gov (United States)

Tatebe, Hisashi; Shiozaki, Kazuhiro

2017-11-01

Target of rapamycin (TOR) is an evolutionarily conserved protein kinase that controls multiple cellular processes upon various intracellular and extracellular stimuli. Since its first discovery, extensive studies have been conducted both in yeast and animal species including humans. Those studies have revealed that TOR forms two structurally and physiologically distinct protein complexes; TOR complex 1 (TORC1) is ubiquitous among eukaryotes including animals, yeast, protozoa, and plants, while TOR complex 2 (TORC2) is conserved in diverse eukaryotic species other than plants. The studies have also identified two crucial regulators of mammalian TORC1 (mTORC1), Ras homolog enriched in brain (RHEB) and RAG GTPases. Of these, RAG regulates TORC1 in yeast as well and is conserved among eukaryotes with the green algae and land plants as apparent exceptions. RHEB is present in various eukaryotes but sporadically missing in multiple taxa. RHEB, in the budding yeast Saccharomyces cerevisiae , appears to be extremely divergent with concomitant loss of its function as a TORC1 regulator. In this review, we summarize the evolutionarily conserved functions of the key regulatory subunits of TORC1 and TORC2, namely RAPTOR, RICTOR, and SIN1. We also delve into the evolutionary conservation of RHEB and RAG and discuss the conserved roles of these GTPases in regulating TORC1.

Heat Pipes Reduce Engine-Exhaust Emissions

Science.gov (United States)

Schultz, D. F.

1986-01-01

Increased fuel vaporization raises engine efficiency. Heat-pipe technology increased efficiency of heat transfer beyond that obtained by metallic conduction. Resulted in both improved engine operation and reduction in fuel consumption. Raw material conservation through reduced dependence on strategic materials also benefit from this type of heat-pipe technology. Applications result in improved engine performance and cleaner environment.

Regulation as a political contest: the probability of conservation of a renewable resource

DEFF Research Database (Denmark)

Brandt, Urs Steiner

2017-01-01

How do the levels of extreme positions of various interest groups influence the conservation policies in the context of a renewable resource conservation contest? To answer this question, a model is provided where conservation policy is determined as a contest between two opposing interest groups......: one in favor of conservation and another in favor of non-conservation. The levels of extreme positions for the conservationalists are determined by their demands about the severity of the conservation strategy that needs to be implemented. For the non-conservation group, the level of extreme position...... is determined by how large the current harvest of the resource should be. The main driver of the model is that resource conservation is realized only if the conservation group wins the contest, which again depends on the relative gain the two contenders receive when winning the contest. The paper derives...

Insights into the Molecular Events That Regulate Heat-Induced Chilling Tolerance in Citrus Fruits.

Science.gov (United States)

Lafuente, María T; Establés-Ortíz, Beatriz; González-Candelas, Luis

2017-01-01

Low non-freezing temperature may cause chilling injury (CI), which is responsible for external quality deterioration in many chilling-sensitive horticultural crops. Exposure of chilling-sensitive citrus cultivars to non-lethal high-temperature conditioning may increase their chilling tolerance. Very little information is available about the molecular events involved in such tolerance. In this work, the molecular events associated with the low temperature tolerance induced by heating Fortune mandarin, which is very sensitive to chilling, for 3 days at 37°C prior to cold storage is presented. A transcriptomic analysis reveals that heat-conditioning has an important impact favoring the repression of genes in cold-stored fruit, and that long-term heat-induced chilling tolerance is an active process that requires activation of transcription factors involved in transcription initiation and of the WRKY family. The analysis also shows that chilling favors degradation processes, which affect lipids and proteins, and that the protective effect of the heat-conditioning treatment is more likely to be related to the repression of the genes involved in lipid degradation than to the modification of fatty acids unsaturation, which affects membrane permeability. Another major factor associated with the beneficial effect of the heat treatment on reducing CI is the regulation of stress-related proteins. Many of the genes that encoded such proteins are involved in secondary metabolism and in oxidative stress-related processes.

Insights into the Molecular Events That Regulate Heat-Induced Chilling Tolerance in Citrus Fruits

Directory of Open Access Journals (Sweden)

María T. Lafuente

2017-06-01

Full Text Available Low non-freezing temperature may cause chilling injury (CI, which is responsible for external quality deterioration in many chilling-sensitive horticultural crops. Exposure of chilling-sensitive citrus cultivars to non-lethal high-temperature conditioning may increase their chilling tolerance. Very little information is available about the molecular events involved in such tolerance. In this work, the molecular events associated with the low temperature tolerance induced by heating Fortune mandarin, which is very sensitive to chilling, for 3 days at 37°C prior to cold storage is presented. A transcriptomic analysis reveals that heat-conditioning has an important impact favoring the repression of genes in cold-stored fruit, and that long-term heat-induced chilling tolerance is an active process that requires activation of transcription factors involved in transcription initiation and of the WRKY family. The analysis also shows that chilling favors degradation processes, which affect lipids and proteins, and that the protective effect of the heat-conditioning treatment is more likely to be related to the repression of the genes involved in lipid degradation than to the modification of fatty acids unsaturation, which affects membrane permeability. Another major factor associated with the beneficial effect of the heat treatment on reducing CI is the regulation of stress-related proteins. Many of the genes that encoded such proteins are involved in secondary metabolism and in oxidative stress-related processes.

Cytoplasmic protein binding to highly conserved sequences in the 3' untranslated region of mouse protamine 2 mRNA, a translationally regulated transcript of male germ cells

International Nuclear Information System (INIS)

Kwon, Y.K.; Hecht, N.B.

1991-01-01

The expression of the protamines, the predominant nuclear proteins of mammalian spermatozoa, is regulated translationally during male germ-cell development. The 3' untranslated region (UTR) of protamine 1 mRNA has been reported to control its time of translation. To understand the mechanisms controlling translation of the protamine mRNAs, we have sought to identify cis elements of the 3' UTR of protamine 2 mRNA that are recognized by cytoplasmic factors. From gel retardation assays, two sequence elements are shown to form specific RNA-protein complexes. Protein binding sites of the two complexes were determined by RNase T1 mapping, by blocking the putative binding sites with antisense oligonucleotides, and by competition assays. The sequences of these elements, located between nucleotides + 537 and + 572 in protamine 2 mRNA, are highly conserved among postmeiotic translationally regulated nuclear proteins of the mammalian testis. Two closely linked protein binding sites were detected. UV-crosslinking studies revealed that a protein of about 18 kDa binds to one of the conserved sequences. These data demonstrate specific protein binding to a highly conserved 3' UTR of translationally regulated testicular mRNA

Profit by conserving energy in your restaurant

Energy Technology Data Exchange (ETDEWEB)

1981-01-01

This manual is aimed at the Canadian restaurant sector with a view of promoting sound energy conservation practices. Monitoring is recommended to identify energy consumption and measure results of a conservation effects. These efforts can be done with respect to selection, operation, and maintenance of restaurant equipment used in food preparation, HVAC systems, refrigeration, water heating, and lighting. Overall building design and planning of new installations are also considered. 27 figs.

Oil and gas conservation in Saskatchewan

International Nuclear Information System (INIS)

Sereda, M.A.

1997-01-01

The Saskatchewan's Oil and Gas Conservation Act provides legislative authority for the Oil and Gas Conservation Regulations, 1985. The main purposes of the Act are to maximize oil and gas recovery, to allow each owner the opportunity of obtaining his share of oil or gas and to protect the environment and prevent waste. The document under review described how this legislative intent is fulfilled through the spacing of wells, the setting of allowables, and approval of waterflood and enhanced recovery projects, while considering equitable drainage of oil and gas. Specific topics dealt with include: vertical well spacing, infill drilling, off-target drilling, horizontal well spacing, and allowables. The concepts of voluntary and statutory pooling as well as voluntary and statutory unitization were explained. Examples of waterflood and enhanced oil recovery projects were provided. The regulation relating to oil and gas conservation were first implemented in 1952 and evolved to their present form through a series of changes and amendments. The most significant changes to the regulations were made in 1991 when horizontal drilling needed to be accommodated. 1 tab

Numerical Modeling of Conjugate Heat Transfer in Fluid Network

Science.gov (United States)

Majumdar, Alok

2004-01-01

Fluid network modeling with conjugate heat transfer has many applications in Aerospace engineering. In modeling unsteady flow with heat transfer, it is important to know the variation of wall temperature in time and space to calculate heat transfer between solid to fluid. Since wall temperature is a function of flow, a coupled analysis of temperature of solid and fluid is necessary. In cryogenic applications, modeling of conjugate heat transfer is of great importance to correctly predict boil-off rate in propellant tanks and chill down of transfer lines. In TFAWS 2003, the present author delivered a paper to describe a general-purpose computer program, GFSSP (Generalized Fluid System Simulation Program). GFSSP calculates flow distribution in complex flow circuit for compressible/incompressible, with or without heat transfer or phase change in all real fluids or mixtures. The flow circuit constitutes of fluid nodes and branches. The mass, energy and specie conservation equations are solved at the nodes where as momentum conservation equations are solved at the branches. The proposed paper describes the extension of GFSSP to model conjugate heat transfer. The network also includes solid nodes and conductors in addition to fluid nodes and branches. The energy conservation equations for solid nodes solves to determine the temperatures of the solid nodes simultaneously with all conservation equations governing fluid flow. The numerical scheme accounts for conduction, convection and radiation heat transfer. The paper will also describe the applications of the code to predict chill down of cryogenic transfer line and boil-off rate of cryogenic propellant storage tank.

An analytical model for annular flow boiling heat transfer in microchannel heat sinks

International Nuclear Information System (INIS)

Megahed, A.; Hassan, I.

2009-01-01

An analytical model has been developed to predict flow boiling heat transfer coefficient in microchannel heat sinks. The new analytical model is proposed to predict the two-phase heat transfer coefficient during annular flow regime based on the separated model. Opposing to the majority of annular flow heat transfer models, the model is based on fundamental conservation principles. The model considers the characteristics of microchannel heat sink during annular flow and eliminates using any empirical closure relations. Comparison with limited experimental data was found to validate the usefulness of this analytical model. The model predicts the experimental data with a mean absolute error 8%. (author)

The Wheat NAC Transcription Factor TaNAC2L Is Regulated at the Transcriptional and Post-Translational Levels and Promotes Heat Stress Tolerance in Transgenic Arabidopsis.

Science.gov (United States)

Guo, Weiwei; Zhang, Jinxia; Zhang, Ning; Xin, Mingming; Peng, Huiru; Hu, Zhaorong; Ni, Zhongfu; Du, Jinkun

2015-01-01

Heat stress poses a serious threat to global crop production. In efforts that aim to mitigate the adverse effects of heat stress on crops, a variety of genetic tools are being used to develop plants with improved thermotolerance. The characterization of important regulators of heat stress tolerance provides essential information for this aim. In this study, we examine the wheat (Triticum aestivum) NAC transcription factor gene TaNAC2L. High temperature induced TaNAC2L expression in wheat and overexpression of TaNAC2L in Arabidopsis thaliana enhanced acquired heat tolerance without causing obvious alterations in phenotype compared with wild type under normal conditions. TaNAC2L overexpression also activated the expression of heat-related genes in the transgenic Arabidopsis plants, suggesting that TaNAC2L may improve heat tolerance by regulating the expression of stress-responsive genes. Notably, TaNAC2L is also regulated at the post-translational level and might be degraded via a proteasome-mediated pathway. Thus, this wheat transcription factor may have potential uses in enhancing thermotolerance in crops.

The Wheat NAC Transcription Factor TaNAC2L Is Regulated at the Transcriptional and Post-Translational Levels and Promotes Heat Stress Tolerance in Transgenic Arabidopsis.

Directory of Open Access Journals (Sweden)

Weiwei Guo

Full Text Available Heat stress poses a serious threat to global crop production. In efforts that aim to mitigate the adverse effects of heat stress on crops, a variety of genetic tools are being used to develop plants with improved thermotolerance. The characterization of important regulators of heat stress tolerance provides essential information for this aim. In this study, we examine the wheat (Triticum aestivum NAC transcription factor gene TaNAC2L. High temperature induced TaNAC2L expression in wheat and overexpression of TaNAC2L in Arabidopsis thaliana enhanced acquired heat tolerance without causing obvious alterations in phenotype compared with wild type under normal conditions. TaNAC2L overexpression also activated the expression of heat-related genes in the transgenic Arabidopsis plants, suggesting that TaNAC2L may improve heat tolerance by regulating the expression of stress-responsive genes. Notably, TaNAC2L is also regulated at the post-translational level and might be degraded via a proteasome-mediated pathway. Thus, this wheat transcription factor may have potential uses in enhancing thermotolerance in crops.

A Canonical DREB2-Type Transcription Factor in Lily Is Post-translationally Regulated and Mediates Heat Stress Response

Directory of Open Access Journals (Sweden)

Ze Wu

2018-03-01

Full Text Available Based on studies of monocot crops and eudicot model plants, the DREB2 class of AP2-type transcription factor has been shown to play crucial roles in various abiotic stresses, especially in the upstream of the heat stress response; however, research on DREB2s has not been reported in non-gramineous monocot plants. Here, we identified a novel DREB2 (LlDREB2B from lily (Lilium longiflorum, which was homologous to AtDREB2A of Arabidopsis, OsDREB2B of rice, and ZmDREB2A of maize. LlDREB2B was induced by heat, cold, salt, and mannitol stress, and its protein had transcriptional activity, was located in the nucleus, was able to bind to the dehydration-responsive element (DRE, and participated in the heat-responsive pathway of HsfA3. Overexpression of LlDREB2B in Arabidopsis activated expression of downstream genes and improved thermotolerance. LlDREB2B was not regulated by alternative splicing; functional transcripts accumulated under either normal or heat-stress conditions. A potential PEST sequence was predicted in LlDREB2B, but the stability of the LlDREB2B protein was not positively affected when the predicated PEST sequence was deleted. Further analysis revealed that the predicated PEST sequence lacked a SBC or SBC-like motif allowing interaction with BPMs and required for negative regulation. Nevertheless, LlDREB2B was still regulated at the post-translational level by interaction with AtDRIP1 and AtDRIP2 of Arabidopsis. In addition, LlDREB2B also interacted with AtRCD1 and LlRCD1 via a potential RIM motif located at amino acids 215–245. Taken together, our results show that LlDREB2B participated in the establishment of thermotolerance, and its regulation was different from that of the orthologs of gramineous and eudicot plants.

A Canonical DREB2-Type Transcription Factor in Lily Is Post-translationally Regulated and Mediates Heat Stress Response.

Science.gov (United States)

Wu, Ze; Liang, Jiahui; Zhang, Shuai; Zhang, Bing; Zhao, Qingcui; Li, Guoqing; Yang, Xi; Wang, Chengpeng; He, Junna; Yi, Mingfang

2018-01-01

Based on studies of monocot crops and eudicot model plants, the DREB2 class of AP2-type transcription factor has been shown to play crucial roles in various abiotic stresses, especially in the upstream of the heat stress response; however, research on DREB2s has not been reported in non-gramineous monocot plants. Here, we identified a novel DREB2 (LlDREB2B) from lily ( Lilium longiflorum ), which was homologous to AtDREB2A of Arabidopsis, OsDREB2B of rice, and ZmDREB2A of maize. LlDREB2B was induced by heat, cold, salt, and mannitol stress, and its protein had transcriptional activity, was located in the nucleus, was able to bind to the dehydration-responsive element (DRE), and participated in the heat-responsive pathway of HsfA3. Overexpression of LlDREB2B in Arabidopsis activated expression of downstream genes and improved thermotolerance. LlDREB2B was not regulated by alternative splicing; functional transcripts accumulated under either normal or heat-stress conditions. A potential PEST sequence was predicted in LlDREB2B, but the stability of the LlDREB2B protein was not positively affected when the predicated PEST sequence was deleted. Further analysis revealed that the predicated PEST sequence lacked a SBC or SBC-like motif allowing interaction with BPMs and required for negative regulation. Nevertheless, LlDREB2B was still regulated at the post-translational level by interaction with AtDRIP1 and AtDRIP2 of Arabidopsis. In addition, LlDREB2B also interacted with AtRCD1 and LlRCD1 via a potential RIM motif located at amino acids 215-245. Taken together, our results show that LlDREB2B participated in the establishment of thermotolerance, and its regulation was different from that of the orthologs of gramineous and eudicot plants.

Natural convection in heat-generating fluids

International Nuclear Information System (INIS)

Bol'shov, Leonid A; Kondratenko, Petr S; Strizhov, Valerii F

2001-01-01

Experimental and theoretical studies of convective heat transfer from a heat-generating fluid confined to a closed volume are reviewed. Theoretical results are inferred from analytical estimates based on the relevant conservation laws and the current understanding of the convective heat-transfer processes. Four basic and one asymptotic regime of heat transfer are identified depending on the heat generation rate. Limiting heat-transfer distribution patterns are found for the lower boundary. Heat transfer in a quasi-two-dimensional geometry is analyzed. Quasi-steady-state heat transfer from a cooling-down fluid without internal heat sources is studied separately. Experimental results and theoretical predictions are compared. (reviews of topical problems)

Energy conservation in new and older buildings

Energy Technology Data Exchange (ETDEWEB)

Ehm, H

1978-07-01

For buildings, the building permits of which had been asked for after 1.9.77, new regulations according to the heat protection term are to be observed. The possibility of restricting heat losses, the simplified manifestation for restricting the transmission heat consumption and details of the new demands and the special regulation for neighbouring buildings are reported. Furthermore, the demands for restricting heat losses due to leaks and for the purpose of ventilation, as well as at buildings with low internal temperatures and buildings for sport and gathering purposes, are dealt with. The simplified heat balance calculation represents a key to the problem solution. In detail it is shown how to make a proper selection of improvement measures.

Energetic retrofitting of industrial heat supply systems. Possibilities of enhancing the efficiency and energy conservation at large combustion engineering plants; Energetische Modernisierung industrieller Waermeversorgungssysteme. Moeglichkeiten der Effizienzsteigerung und der Energieeinsparung an grossen feuerungstechnischen Anlagen

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-12-15

In the contribution under consideration, the Deutsche Energie-Agentur GmbH (Berlin, Federal Republic of Germany) reports on an energetic modernization of industrial heat supply systems. Possibilities of an enhancement of the energetic efficiency and energy conservation at large combustion engineering plants are described. After an introduction to this theme, the author of this contribution provides an overview of the optimization of heat supply systems, and reports on the following aspects: Optimisation of the heat demand; energy efficient heat generation; heat recovery; energy efficient conversion technology and generation technology; associate partners for more energy efficiency in industry and commerce; best practice examples.

Heating a school by means of waste heat from an ice hall

International Nuclear Information System (INIS)

2001-01-01

As the first building in Norway, Gimle school in Halden can be heated by means of a special combination system that gives up waste heat from a nearby ice hall and earth heat. This system will reduce the expenses of the municipality with the equivalent of USD 30 000 per year, or 618 000 kWh. 308 000 kWh comes from the refrigeration plant of the ice hall and 310 000 kWh from the ground. Although the system is both environmentally friendly end energy conserving, financial state support has been refused

Urban district heating using nuclear heat - a survey

International Nuclear Information System (INIS)

Beresovski, T.; Oliker, I.

1979-01-01

The use of heat from nuclear power plants is of great interest in connection with projected future expansions of large urban district heating systems. Oil price escalation and air pollution from increased burning of fossil fuels are substantial incentivers for the adoption of nuclear heat and power plants. The cost of the hot water piping system from the nuclear plant to the city is a major factor in determining the feasibility of using nuclear heat. To achieve reasonable costs, the heat load should be at least 1500 MW(th), transport temperatures 125-200 0 C and distances preferably 50 km or less. Heat may be extracted from the turbines of conventional power reactors. Alternatively, some special-purpose smaller reactors are under development which are specially suited to production of heat with little or no power coproduct. Many countries are conducting studies of future expansions of district heating systems to use nuclear heat. Several countries are developing technology suitable for this application. Actual experience with the use of nuclear heat for district heating is currently being gained only in the USSR, however. While district heating appears to be a desirable technology at a time of increasing fossil-fuel costs, the use of nuclear heat will require siting of nuclear plants within transmission radius of cities. The institutional barries toward use of nuclear heating will have to be overcome before the energy conservation potential of this approach can be realized on a significant scale. (author)

Transectional heat transfer in thermoregulating bigeye tuna (Thunnus obesus) - a 2D heat flux model.

Science.gov (United States)

Boye, Jess; Musyl, Michael; Brill, Richard; Malte, Hans

2009-11-01

We developed a 2D heat flux model to elucidate routes and rates of heat transfer within bigeye tuna Thunnus obesus Lowe 1839 in both steady-state and time-dependent settings. In modeling the former situation, we adjusted the efficiencies of heat conservation in the red and the white muscle so as to make the output of the model agree as closely as possible with observed cross-sectional isotherms. In modeling the latter situation, we applied the heat exchanger efficiencies from the steady-state model to predict the distribution of temperature and heat fluxes in bigeye tuna during their extensive daily vertical excursions. The simulations yielded a close match to the data recorded in free-swimming fish and strongly point to the importance of the heat-producing and heat-conserving properties of the white muscle. The best correspondence between model output and observed data was obtained when the countercurrent heat exchangers in the blood flow pathways to the red and white muscle retained 99% and 96% (respectively) of the heat produced in these tissues. Our model confirms that the ability of bigeye tuna to maintain elevated muscle temperatures during their extensive daily vertical movements depends on their ability to rapidly modulate heating and cooling rates. This study shows that the differential cooling and heating rates could be fully accounted for by a mechanism where blood flow to the swimming muscles is either exclusively through the heat exchangers or completely shunted around them, depending on the ambient temperature relative to the body temperature. Our results therefore strongly suggest that such a mechanism is involved in the extensive physiological thermoregulatory abilities of endothermic bigeye tuna.

Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria

Energy Technology Data Exchange (ETDEWEB)

Herrou, Julien; Willett, Jonathan W.; Czy; #380; , Daniel M.; Babnigg, Gyorgy; Kim, Youngchang; Crosson, Sean (UC)

2016-12-19

Brucella abortusσ^E1is an EcfG family sigma factor that regulates the transcription of dozens of genes in response to diverse stress conditions and is required for maintenance of chronic infection in a mouse model. A putative ATP-binding cassette transporter operon,bab1_0223-bab1_0226, is among the most highly activated gene sets in the σ^E1regulon. The proteins encoded by the operon resemble quaternary ammonium-compatible solute importers but are most similar in sequence to the broadly conserved YehZYXW system, which remains largely uncharacterized. Transcription ofyehZYXWis activated by the general stress sigma factor σ^SinEnterobacteriaceae, which suggests a functional role for this transport system in bacterial stress response across the classesAlphaproteobacteriaandGammaproteobacteria. We present evidence thatB. abortusYehZYXW does not function as an importer of known compatible solutes under physiological conditions and does not contribute to the virulence defect of a σ^E1-null strain. The solein vitrophenotype associated with genetic disruption of this putative transport system is reduced growth in the presence of high Li⁺ion concentrations. A crystal structure ofB. abortusYehZ revealed a class II periplasmic binding protein fold with significant structural homology toArchaeoglobus fulgidusProX, which binds glycine betaine. However, the structure

Solar-assisted heat pump – A sustainable system for low-temperature water heating applications

International Nuclear Information System (INIS)

Chaturvedi, S.K.; Gagrani, V.D.; Abdel-Salam, T.M.

2014-01-01

Highlights: • DX-SAHP water heaters systems are economical as well as energy conserving. • The economic analysis is performed using the life cycle cost (LCC) analysis. • LCC can be optimized with respect to the collector area at a specific temperature. • For high load temperature range a two stage heat pump system is more appropriate. - Abstract: Direct expansion solar assisted heat pump systems (DX-SAHP) have been widely used in many applications including water heating. In the DX-SAHP systems the solar collector and the heat pump evaporator are integrated into a single unit in order to transfer the solar energy to the refrigerant. The present work is aimed at studying the use of the DX-SAHP for low temperature water heating applications. The novel aspect of this paper involves a detailed long-term thermo-economic analysis of the energy conservation potential and economic viability of these systems. The thermal performance is simulated using a computer program that incorporates location dependent radiation, collector, economic, heat pump and load data. The economic analysis is performed using the life cycle cost (LCC) method. Results indicate that the DX-SAHP water heaters systems when compared to the conventional electrical water heaters are both economical as well as energy conserving. The analysis also reveals that the minimum value of the system life cycle cost is achieved at optimal values of the solar collector area as well as the compressor displacement capacity. Since the cost of SAHP system presents a barrier to mass scale commercialization, the results of the present study indicating that the SAHP life cycle cost can be minimized by optimizing the collector area would certainly be helpful in lowering, if not eliminating, the economic barrier to these systems. Also, at load temperatures higher than 70 °C, the performance of the single stage heat pump degrades to the extent that its cost and efficiency advantages over the electric only system are

A conserved inter-domain communication mechanism regulates the ATPase activity of the AAA-protein Drg1.

Science.gov (United States)

Prattes, Michael; Loibl, Mathias; Zisser, Gertrude; Luschnig, Daniel; Kappel, Lisa; Rössler, Ingrid; Grassegger, Manuela; Hromic, Altijana; Krieger, Elmar; Gruber, Karl; Pertschy, Brigitte; Bergler, Helmut

2017-03-17

AAA-ATPases fulfil essential roles in different cellular pathways and often act in form of hexameric complexes. Interaction with pathway-specific substrate and adaptor proteins recruits them to their targets and modulates their catalytic activity. This substrate dependent regulation of ATP hydrolysis in the AAA-domains is mediated by a non-catalytic N-terminal domain. The exact mechanisms that transmit the signal from the N-domain and coordinate the individual AAA-domains in the hexameric complex are still the topic of intensive research. Here, we present the characterization of a novel mutant variant of the eukaryotic AAA-ATPase Drg1 that shows dysregulation of ATPase activity and altered interaction with Rlp24, its substrate in ribosome biogenesis. This defective regulation is the consequence of amino acid exchanges at the interface between the regulatory N-domain and the adjacent D1 AAA-domain. The effects caused by these mutations strongly resemble those of pathological mutations of the AAA-ATPase p97 which cause the hereditary proteinopathy IBMPFD (inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia). Our results therefore suggest well conserved mechanisms of regulation between structurally, but not functionally related members of the AAA-family.

African wildlife conservation and the evolution of hunting institutions

Science.gov (United States)

't Sas-Rolfes, Michael

2017-11-01

Hunting regulation presents a significant challenge for contemporary global conservation governance. Motivated by various incentives, hunters may act legally or illegally, for or against the interests of conservation. Hunter incentives are shaped by the interactions between unevenly evolving formal and informal institutions, embedded in socio-ecological systems. To work effectively for conservation, regulatory interventions must take these evolving institutional interactions into account. Drawing on analytical tools from evolutionary institutional economics, this article examines the trajectory of African hunting regulation and its consequences. Concepts of institutional dynamics, fit, scale, and interplay are applied to case studies of rhinoceros and lion hunting to highlight issues of significance to conservation outcomes. These include important links between different forms of hunting and dynamic interplay with institutions of trade. The case studies reveal that inappropriate formal regulatory approaches may be undermined by adaptive informal market responses. Poorly regulated hunting may lead to calls for stricter regulations or bans, but such legal restrictions may in turn perversely lead to more intensified and organised illegal hunting activity, further undermining conservation objectives. I conclude by offering insights and recommendations to guide more effective future regulatory interventions and priorities for further research. Specifically, I advocate approaches that move beyond simplistic regulatory interventions toward more complex, but supportive, institutional arrangements that align formal and informal institutions through inclusive stakeholder engagement.

Conserving energy by eliminating waste

Energy Technology Data Exchange (ETDEWEB)

Jones, N. H.

1979-07-01

Some ways in which energy is wasted in industry are discussed and the losses involved are quantified. Reference is made to a particular loss in annealing furnaces; wasted energy in factory and lighting systems; heat generated by motors and lighting and by such processes as welding; unlagged hot pipework and most hot processes; and poor building envelope features. It is concluded that an industry should declare its intention of conservation at the highest possible level, identify conservation as a manufacturing target, and invest the responsibility in people for whom it is a full-time activity. (MCW)

Energy conservation by technical means: the control systems matter.; Energiesparen durch technische Hilfsmittel: auf die Regelkreise kommt es an.

Energy Technology Data Exchange (ETDEWEB)

Benecke, J. [Verein Deutscher Ingenieure (VDI), Muenchen (Germany)

2000-07-01

The new German regulation on energy conservation in buildings (draft) offers certain flexibility for choosing the quality of the building envelope (thermal resistance and air tightness) and of the HV equipment (AC not considered) in order to balance and minimize the yearly heating-energy demand. Up to now, there was little consideration given to control systems which are able to assist the inhabitants in using heating and ventilation efficiently. The performance of such systems is being discussed. (orig.) [German] In Deutschland betraegt der Anteil der Raumheizenergie am Endenergieverbrauch rund 35%; ihr Anteil am Endenergieverbrauch der Haushalte und Kleinverbraucher betraegt rund 76%. Die Vorgaben der bisherigen Waermeschutzverordnungen und der geplanten Energieeinsparverordnung veranschaulichen das Energieeinsparpotential, das durch effizientere Energienutzung im Gebaeudebereich erschlossen werden kann. (orig.)

Hydrological self-regulation of domed peatlands in south-east Asia and consequences for conservation and restoration

Directory of Open Access Journals (Sweden)

R. Dommain

2010-10-01

Full Text Available This article explores the hydrological constraints on the existence of forested peat domes (peat swamp forests in the humid tropics, the self-regulation mechanisms that enable them to persist and the implications for restoration of damaged domes. The most important requirement for the preservation of peat is permanent saturation by water. The variable input of precipitation must be translated into a constant water supply to the peat mound. In intact tropical peat swamp domes, water is stored above the peat surface in depressions between hummocks that surround tree trunks and between spreading buttress roots. This above-ground water store is analogous to the water stored in the loose upper layer of peat and vegetation in Sphagnum bogs. The horizontal differentiation of the peat swamp forest floor into hummocks with limited hydraulic conductivity and depressions with high storage capacity resembles the hummock-hollow patterning of these Sphagnum bogs. Hummocks and other surface elements functionally resemble V-notch weirs that regulate water availability. Buttressed trees play a key role in providing the structural elements for hydrological self-regulation. An additional level of regulation is found in the concentric zonation of forest types with increased presence of buttressed trees on steeper margins. Conservation and restoration efforts should take into account the inter-relationships between trees, water and peat and the hydrological feedbacks that operate as a consequence.

ROUNDTABLE - SESSION 2 EXPLOITATION, CONSERVATION AND LEGISLATION

Directory of Open Access Journals (Sweden)

EDSMAN L.

2004-01-01

Full Text Available The link between socioeconomics and conservation and the role of legislation in conservation work was discussed in the group with participants from nine European countries. Interest and knowledge among the general public, stakeholders and managers is the key to successful conservation of native crayfish species. Exploitation and conservation do not necessarily exclude each other. A controlled fishery, where it can be sustained, may be an essential tool for conservation by increasing the general awareness and involving more people in the task of protecting the native crayfish species. This strategy is mainly possible for the noble crayfish in the northern part of its distribution, where strong traditions connected to crayfish also exist. A balance between utilisation and overexploitation has to be found and local guidelines for sustainable exploitation produced. Media, the Internet and educational material aimed at schools and stakeholders are excellent ways of reaching a wide audience with information. Universal objectives, rules and regulations at the European level are desirable and the noble crayfish and the stone crayfish should be included in Annex II of the Habitat Directive. Based on this framework detailed regulations are best worked out at the national level, considering the specific crayfish situation in the country. Information about the legislation, the purpose of the legislation and the consequences when not obeying it should be distributed. Stricter regulation of the trade with live alien crayfish is vital because of the associated risk of introducing new diseases and species.

Heat shock instructs hESCs to exit from the self-renewal program through negative regulation of OCT4 by SAPK/JNK and HSF1 pathway.

Science.gov (United States)

Byun, Kyunghee; Kim, Taek-Kyun; Oh, Jeehyun; Bayarsaikhan, Enkhjargal; Kim, Daesik; Lee, Min Young; Pack, Chan-Gi; Hwang, Daehee; Lee, Bonghee

2013-11-01

Environmental factors affect self-renewal of stem cells by modulating the components of self-renewal networks. Heat shock, an environmental factor, induces heat shock factors (HSFs), which up-regulate stress response-related genes. However, the link of heat shock to self-renewal of stem cells has not been elucidated yet. Here, we present the direct link of heat shock to a core stem cell regulator, OCT4, in the self-renewal network through SAPK/JNK and HSF1 pathway. We first showed that heat shock initiated differentiation of human embryonic stem cells (hESCs). Gene expression analysis revealed that heat shock increased the expression of many genes involved in cellular processes related to differentiation of stem cells. We then examined the effects of HSFs induced by heat shock on core self-renewal factors. Among HSFs, heat shock induced mainly HSF1 in hESCs. The HSF1 repressed the expression of OCT4, leading to the differentiation of hESCs and the above differentiation-related gene expression change. We further examined the effects of the upstream MAP (mitogen-activated protein) kinases of HSF1 on the repression of OCT4 expression by HSF1. Among the MAP kinases, SAPK/JNK controlled predominantly the repression of the OCT4 expression by HSF1. The direct link of heat shock to the core self-renewal regulator through SAPK/JNK and HSF1 provides a fundamental basis for understanding the effect of heat and other stresses involving activation of HSF1 on the self-renewal program and further controlling differentiation of hESCs in a broad spectrum of stem cell applications using these stresses. © 2013.

Phase change based cooling for high burst mode heat loads with temperature regulation above the phase change temperature

Science.gov (United States)

The United States of America as represented by the United States Department of Energy

2009-12-15

An apparatus and method for transferring thermal energy from a heat load is disclosed. In particular, use of a phase change material and specific flow designs enables cooling with temperature regulation well above the fusion temperature of the phase change material for medium and high heat loads from devices operated intermittently (in burst mode). Exemplary heat loads include burst mode lasers and laser diodes, flight avionics, and high power space instruments. Thermal energy is transferred from the heat load to liquid phase change material from a phase change material reservoir. The liquid phase change material is split into two flows. Thermal energy is transferred from the first flow via a phase change material heat sink. The second flow bypasses the phase change material heat sink and joins with liquid phase change material exiting from the phase change material heat sink. The combined liquid phase change material is returned to the liquid phase change material reservoir. The ratio of bypass flow to flow into the phase change material heat sink can be varied to adjust the temperature of the liquid phase change material returned to the liquid phase change material reservoir. Varying the flowrate and temperature of the liquid phase change material presented to the heat load determines the magnitude of thermal energy transferred from the heat load.

Characterization of Bombyx mori mitochondrial transcription factor A, a conserved regulator of mitochondrial DNA.

Science.gov (United States)

Sumitani, Megumi; Kondo, Mari; Kasashima, Katsumi; Endo, Hitoshi; Nakamura, Kaoru; Misawa, Toshihiko; Tanaka, Hiromitsu; Sezutsu, Hideki

2017-04-15

In the present study, we initially cloned and characterized a mitochondrial transcription factor A (Tfam) homologue in the silkworm, Bombyx mori. Bombyx mori TFAM (BmTFAM) localized to mitochondria in cultured silkworm and human cells, and co-localized with mtDNA nucleoids in human HeLa cells. In an immunoprecipitation analysis, BmTFAM was found to associate with human mtDNA in mitochondria, indicating its feature as a non-specific DNA-binding protein. In spite of the low identity between BmTFAM and human TFAM (26.5%), the expression of BmTFAM rescued mtDNA copy number reductions and enlarged mtDNA nucleoids in HeLa cells, which were induced by human Tfam knockdown. Thus, BmTFAM compensates for the function of human TFAM in HeLa cells, demonstrating that the mitochondrial function of TFAM is highly conserved between silkworms and humans. BmTfam mRNA was strongly expressed in early embryos. Through double-stranded RNA (dsRNA)-based RNA interference (RNAi) in silkworm embryos, we found that the knockdown of BmTFAM reduced the amount of mtDNA and induced growth retardation at the larval stage. Collectively, these results demonstrate that BmTFAM is a highly conserved mtDNA regulator and may be a good candidate for investigating and modulating mtDNA metabolism in this model organism. Copyright © 2017 Elsevier B.V. All rights reserved.

Energy conservation for houses and its calculation methods

Energy Technology Data Exchange (ETDEWEB)

Lee, S H

1981-04-01

The concept of energy conservation of houses has been developed and began to be applied widely since the first oil crisis. Now we can say definitely that insulating a house is the most effective way of saving energy, and the renewable energy sources are useful only when the demand for space heating and hot water is minimized by insulating. If a house is well insulated, it will need a much smaller, simpler and cheaper heating system. So it will be less efficient to put a solar collector and wind generator on a poorly insulated house. Architects and engineers should have a certain level of practical knowledge of insulation for house to persuade customers using insulating materials and structure. Moreover, it is very essential to amend the existing building codes in order to facilitate this basic necessity. For instance, the Building Regulations of Denmark requires a U-value of 0.4 W/m/sup 2/ degC for heavy weight external wall. If the cavity wall has outer and inner leaf of just normal brick with internal finish of 20 mm cement mortar, which is a typical wall construction for houses in Korea, the thickness of insulation materials to the cavity can be calculated in order to fullfil the U-value of 0.4 W/m/sup 2/ degC in addition to the cavity of the external heavy wall: expanded polyurethane 58 mm, urea formaldehyde foam 67 mm, expanded polystyrene 78 mm, mineral wool 94 mm. The economic feasibility of solar heating system has been calculated. By applying 25% of the year inflation ratio for fuel cost, the result turns out economically comparable with solar heating systems.

Careers in the Renewable Energy and Conservation Professions and Trades.

Science.gov (United States)

Department of Energy, Washington, DC.

Many kinds of jobs can be found in the renewable energy and energy conservation industries. This pamphlet indicates that a large career potential exists within the solar and conservation professions and trades. These careers consist of individuals who design, build, or install solar heating or hot water systems, who implement energy conservation…

Safety provision during heating of coal downcast shafts with gas heat generators using degassed methane

Directory of Open Access Journals (Sweden)

В. Р. Алабьев

2017-06-01

Together with heat generators of mixed type the article also describes a working principle of heat generator of indirect action type, which to the fullest extent possible meets requirements of Russian Federation legislation and regulation for application of this heat generators in coal mines conditions. The article has a principal working scheme of heat unit layout using this type of generator. It is shown that after development of corresponding normative documents regulating processes of design, construction and operation of heating units using heaters of indirect action, their application in Russian coal mines will be possible without breaking Safety standards and rules.

Heat stress induced changes in metabolic regulators of donkeys from arid tracts in India

Directory of Open Access Journals (Sweden)

Kataria N.

2012-05-01

Full Text Available To find out heat stress induced changes in metabolic regulators of donkeys from arid tracts in India, blood samples were collected to harvest the serum during moderate and extreme hot ambiences. The metabolic enzymes determined were sorbitol dehydrogenase, malate dehydrogenase, glucose-6-phosphate dehydrogenase, glutamate dehydrogenase, ornithine carbamoyl transferase, gammaglutamayl transferase, 5’nucleotidase, glucose-6-phosphatase, arginase, and aldolase. The mean values of all the serum enzymes increased significantly (p≤0.05 during hot ambience as compared to respective values during moderate ambience. It was concluded that increased activity of all the enzymes in the serum was due to modulation of metabolic reactions to combat the effect of hot ambience on the animals. Activation of gluconeogenesis along with hexose monophosphate shunt and urea cycle probably helped the animals to combat the heat stress.

Sensing the Heat Stress by Mammalian Cells

OpenAIRE

Cates Jordan; Graham Garrett C; Omattage Natalie; Pavesich Elizabeth; Setliff Ian; Shaw Jack; Smith Caitlin; Lipan Ovidiu

2011-01-01

Abstract Background The heat-shock response network controls the adaptation and survival of the cell against environmental stress. This network is highly conserved and is connected with many other signaling pathways. A key element of the heat-shock network is the heat-shock transcription factor-1 (HSF), which is transiently activated by elevated temperatures. HSF translocates to the nucleus upon elevated temperatures, forming homotrimeric complexes. The HSF homotrimers bind to the heat shock ...

75 FR 52892 - Energy Conservation Program for Consumer Products: Test Procedures for Residential Water Heaters...

Science.gov (United States)

2010-08-30

... ``Energy Conservation Program for Consumer Products Other Than Automobiles,'' including residential water... final rule revising energy conservation standards for residential water heaters, direct heating.... EERE-2009-BT-TP-0013] RIN 1904-AB95 Energy Conservation Program for Consumer Products: Test Procedures...

Evolutionary conservation of regulatory elements in vertebrate HOX gene clusters

Energy Technology Data Exchange (ETDEWEB)

Santini, Simona; Boore, Jeffrey L.; Meyer, Axel

2003-12-31

Due to their high degree of conservation, comparisons of DNA sequences among evolutionarily distantly-related genomes permit to identify functional regions in noncoding DNA. Hox genes are optimal candidate sequences for comparative genome analyses, because they are extremely conserved in vertebrates and occur in clusters. We aligned (Pipmaker) the nucleotide sequences of HoxA clusters of tilapia, pufferfish, striped bass, zebrafish, horn shark, human and mouse (over 500 million years of evolutionary distance). We identified several highly conserved intergenic sequences, likely to be important in gene regulation. Only a few of these putative regulatory elements have been previously described as being involved in the regulation of Hox genes, while several others are new elements that might have regulatory functions. The majority of these newly identified putative regulatory elements contain short fragments that are almost completely conserved and are identical to known binding sites for regulatory proteins (Transfac). The conserved intergenic regions located between the most rostrally expressed genes in the developing embryo are longer and better retained through evolution. We document that presumed regulatory sequences are retained differentially in either A or A clusters resulting from a genome duplication in the fish lineage. This observation supports both the hypothesis that the conserved elements are involved in gene regulation and the Duplication-Deletion-Complementation model.

Geothermal energy of Slovakia - CO2 emissions reduction contribution potential (background study for conservative and non-conservative approach

Directory of Open Access Journals (Sweden)

Branislav Fričovský

2012-12-01

Full Text Available Total geothermal energy potential is estimated for 209 714 TJ per year or 6 650 MWth. Natural conditions define a use of thermalwaters for heat generation only. Accepting proportion of real achievable output of geothermal projects in the non-conservative scenarioat a rate of 1 861 MWth or 13 440 TJ per year, yearly carbon dioxide savings are up to reach 0,357 MtCO2.yr-1 or 12,5 of cumulativeMtCO2 in 35 years. By a contrast, introduction of conservative approach points to increase in a geothermal heat production from 145 to243 TJ per period or 6 944 TJ of cumulative 35 years production, with a real outcome of 0,45 MtCO2 cumulative carbon dioxidesavings, corresponding to yearly real savings from 9,4 .10-3 to 15,8 .10-3 MtCO2.

Regulating edible insects: the challenge of adressing food security, nature conservation, and the erosion of traditional food culture

DEFF Research Database (Denmark)

Halloran, Afton Marina Szasz; Vantomme, Paul; Hanboonsong, Y.

2015-01-01

Entomophagy is a common practice in many regions of the world but there are few examples of national regulations that govern insects for human consumption. Where entomophagy is not common, the current regulatory discourse focuses primarily on food safety and consumer protection. In countries where...... species, they do not appear explicitly in dietary guidelines. Although food safety is a major concern, it can undermine the importance of nature conservation, traditional food culture, food security, and potential economic development. Thus, entomophagy should be viewed holistically and development...

76 FR 60933 - Antarctic Conservation Act Permit Applications

Science.gov (United States)

2011-09-30

... NATIONAL SCIENCE FOUNDATION Antarctic Conservation Act Permit Applications AGENCY: National... Conservation Act of 1978. DATES: Interested parties are invited to submit written data, comments, or views with... Regulation for conduct of a flight from South America, over the South Pole, landing at Teniente Marsh Base...

Mathematical model for calculation of the heat-hydraulic modes of heating points of heat-supplying systems

Science.gov (United States)

Shalaginova, Z. I.

2016-03-01

The mathematical model and calculation method of the thermal-hydraulic modes of heat points, based on the theory of hydraulic circuits, being developed at the Melentiev Energy Systems Institute are presented. The redundant circuit of the heat point was developed, in which all possible connecting circuits (CC) of the heat engineering equipment and the places of possible installation of control valve were inserted. It allows simulating the operating modes both at central heat points (CHP) and individual heat points (IHP). The configuration of the desired circuit is carried out automatically by removing the unnecessary links. The following circuits connecting the heating systems (HS) are considered: the dependent circuit (direct and through mixing elevator) and independent one (through the heater). The following connecting circuits of the load of hot water supply (HWS) were considered: open CC (direct water pumping from pipelines of heat networks) and a closed CC with connecting the HWS heaters on single-level (serial and parallel) and two-level (sequential and combined) circuits. The following connecting circuits of the ventilation systems (VS) were also considered: dependent circuit and independent one through a common heat exchanger with HS load. In the heat points, water temperature regulators for the hot water supply and ventilation and flow regulators for the heating system, as well as to the inlet as a whole, are possible. According to the accepted decomposition, the model of the heat point is an integral part of the overall heat-hydraulic model of the heat-supplying system having intermediate control stages (CHP and IHP), which allows to consider the operating modes of the heat networks of different levels connected with each other through CHP as well as connected through IHP of consumers with various connecting circuits of local systems of heat consumption: heating, ventilation and hot water supply. The model is implemented in the Angara data

Heat generation and heating limits for the IRUS LLRW disposal facility

International Nuclear Information System (INIS)

Donders, R.E.; Caron, F.

1995-10-01

Heat generation from radioactive decay and chemical degradation must be considered when implementing low-level radioactive waste (LLRW) disposal. This is particularly important when considering the management of spent radioisotope sources. Heating considerations and temperature calculations for the proposed IRUS (Intrusion Resistant Underground Structure) near-surface disposal facility are presented. Heat transfer calculations were performed using a finite element code with realistic but somewhat conservative heat transfer parameters and environmental boundary conditions. The softening-temperature of the bitumen waste-form (38 deg C) was found to be the factor that limits the heat generation rate in the facility. This limits the IRUS heat rate, assuming a uniform source term, to 0.34 W/m 3 . If a reduced general heat-limit is considered, then some higher-heat packages can be accepted with restrictions placed on their location within the facility. For most LLRW, heat generation from radioactive decay and degradation are a small fraction of the IRUS heating limits. However, heating restrictions will impact on the disposal of higher-activity radioactive sources. High activity 60 Co sources will require decay-storage periods of about 70 years, and some 137 Cs will need to bed disposed of in facilities designed for higher-heat waste. (author). 21 refs., 8 tabs., 2 figs

Effect of vibrational stress and spaceflight on regulation of heat shock proteins hsp70 and hsp27 in human lymphocytes (Jurkat)

Science.gov (United States)

Cubano, L. A.; Lewis, M. L.

2001-01-01

Heat shock protein levels are increased in cells as a result of exposure to stress. To determine whether heat shock protein regulation could be used to evaluate stress in cells during spaceflight, the response of Jurkat cells to spaceflight and simulated space shuttle launch vibration was investigated by evaluating hsp70 and hsp27 gene expression. Gene expression was assessed by reverse transcription-polymerase chain reaction using mRNA extracted from vibrated, nonvibrated, space-flown, and ground control cells. Results indicate that mechanical stresses of vibration and low gravity do not up-regulate the mRNA for hsp70, although the gene encoding hsp27 is up-regulated by spaceflight but not by vibration. In ground controls, the mRNA for hsp70 and hsp27 increased with time in culture. We conclude that hsp70 gene expression is a useful indicator of stress related to culture density but is not an indicator of the stresses of launch vibration or microgravity. Up-regulation of hsp27 gene expression in microgravity is a new finding.

Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.

Directory of Open Access Journals (Sweden)

Yan Hao

2011-05-01

Full Text Available Elevation of the second messenger cGMP by nitric oxide (NO activates the cGMP-dependent protein kinase PKG, which is key in regulating cardiovascular, intestinal, and neuronal functions in mammals. The NO-cGMP-PKG signaling pathway is also a major therapeutic target for cardiovascular and male reproductive diseases. Despite widespread effects of PKG activation, few molecular targets of PKG are known. We study how EGL-4, the Caenorhabditis elegans PKG ortholog, modulates foraging behavior and egg-laying and seeks the downstream effectors of EGL-4 activity. Using a combination of unbiased forward genetic screen and proteomic analysis, we have identified a conserved SAEG-1/SAEG-2/HDA-2 histone deacetylase complex that is specifically recruited by activated nuclear EGL-4. Gene expression profiling by microarrays revealed >40 genes that are sensitive to EGL-4 activity in a SAEG-1-dependent manner. We present evidence that EGL-4 controls egg laying via one of these genes, Y45F10C.2, which encodes a novel protein that is expressed exclusively in the uterine epithelium. Our results indicate that, in addition to cytoplasmic functions, active EGL-4/PKG acts in the nucleus via a conserved Class I histone deacetylase complex to regulate gene expression pertinent to behavioral and physiological responses to cGMP. We also identify transcriptional targets of EGL-4 that carry out discrete components of the physiological response.

Potential regulation on the climatic effect of Tibetan Plateau heating by tropical air-sea coupling in regional models

Science.gov (United States)

Wang, Ziqian; Duan, Anmin; Yang, Song

2018-05-01

Based on the conventional weather research and forecasting (WRF) model and the air-sea coupled mode WRF-OMLM, we investigate the potential regulation on the climatic effect of Tibetan Plateau (TP) heating by the air-sea coupling over the tropical Indian Ocean and western Pacific. Results indicate that the TP heating significantly enhances the southwesterly monsoon circulation over the northern Indian Ocean and the South Asia subcontinent. The intensified southwesterly wind cools the sea surface mainly through the wind-evaporation-SST (sea surface temperature) feedback. Cold SST anomaly then weakens monsoon convective activity, especially that over the Bay of Bengal, and less water vapor is thus transported into the TP along its southern slope from the tropical oceans. As a result, summer precipitation decreases over the TP, which further weakens the TP local heat source. Finally, the changed TP heating continues to influence the summer monsoon precipitation and atmospheric circulation. To a certain extent, the air-sea coupling over the adjacent oceans may weaken the effect of TP heating on the mean climate in summer. It is also implied that considerations of air-sea interaction are necessary in future simulation studies of the TP heating effect.

Wound-Induced Polyploidization: Regulation by Hippo and JNK Signaling and Conservation in Mammals.

Science.gov (United States)

Losick, Vicki P; Jun, Albert S; Spradling, Allan C

2016-01-01

Tissue integrity and homeostasis often rely on the proliferation of stem cells or differentiated cells to replace lost, aged, or damaged cells. Recently, we described an alternative source of cell replacement- the expansion of resident, non-dividing diploid cells by wound-induced polyploidization (WIP). Here we show that the magnitude of WIP is proportional to the extent of cell loss using a new semi-automated assay with single cell resolution. Hippo and JNK signaling regulate WIP; unexpectedly however, JNK signaling through AP-1 limits rather than stimulates the level of Yki activation and polyploidization in the Drosophila epidermis. We found that polyploidization also quantitatively compensates for cell loss in a mammalian tissue, mouse corneal endothelium, where increased cell death occurs with age in a mouse model of Fuchs Endothelial Corneal Dystrophy (FECD). Our results suggest that WIP is an evolutionarily conserved homeostatic mechanism that maintains the size and synthetic capacity of adult tissues.

A review of state regulations that exceed those of the federal Resource Conservation and Recovery Act (RCRA)

International Nuclear Information System (INIS)

Coutant, C.C.; Heckman, C.L.

1988-04-01

This report identifies and provides information on state hazardous waste management programs and regulations in states where the US Department of Energy (DOE) has facilities. The objective is to describe for the DOE defense program and its contractors how state requirements are more stringent than the federal regulations under the Resource Conservation and Recovery Act (RCRA). DOE defense programs are located in 13 of the 50 states. Most of these states have regulations that are essentially equivalent to the federal RCRA requirements as they existed prior to the 1984 amendments, but their regulations are, in most instances, more stringment than the federal requirements. Differences are both substantive and procedural, and they are summarized and tabulated herein. All but three of these 13 states have been granted Final Authorization from the US Environmental Protection Agency (EPA) to operate their own hazardous waste management program in accord with the federal RCRA program prior to the 1984 amendments; two of the three others have some stage of Interim Authorization. EPA currently administers all of the provisions of the 1984 amendments, including requirements for corrective action under Sect. 3004(u). Two states, Colorado and Tennessee, have been granted revisions to their Final Authorizations delegating responsibility for the hazardous wastes. Responsible state agencies (with appropriate telephone numbers) are indicated, as are the relevant laws and current regulatory statutes

Statistically derived conservation equations for fluid particle flows

International Nuclear Information System (INIS)

Reyes, J.N. Jr.

1989-01-01

The behavior of water droplets in a heated nuclear fuel channel is of significant interest to nuclear reactor safety studies pertaining to loss-of-coolant accidents. This paper presents the derivation of the mass, momentum, and energy conservation equations for a distribution of fluid particles (bubbles or droplets) transported by a continuous fluid medium. When coupled with the appropriate closure equations, the conservation equations can be used to model nonequilibrium, two-phase, dispersed, fluid flow behavior

75 FR 70083 - Emergency Forest Restoration Program and Emergency Conservation Program

Science.gov (United States)

2010-11-17

... Restoration Program and Emergency Conservation Program AGENCY: Farm Service Agency, USDA. ACTION: Interim rule. SUMMARY: The Farm Service Agency (FSA) is amending regulations as required by the Food, Conservation, and... as follows: PART 701--EMERGENCY CONSERVATION PROGRAM, EMERGENCY FOREST RESTORATION PROGRAM, AND...

A bioinformatic survey of distribution, conservation, and probable functions of LuxR solo regulators in bacteria

Science.gov (United States)

Subramoni, Sujatha; Florez Salcedo, Diana Vanessa; Suarez-Moreno, Zulma R.

2015-01-01

LuxR solo transcriptional regulators contain both an autoinducer binding domain (ABD; N-terminal) and a DNA binding Helix-Turn-Helix domain (HTH; C-terminal), but are not associated with a cognate N-acyl homoserine lactone (AHL) synthase coding gene in the same genome. Although a few LuxR solos have been characterized, their distributions as well as their role in bacterial signal perception and other processes are poorly understood. In this study we have carried out a systematic survey of distribution of all ABD containing LuxR transcriptional regulators (QS domain LuxRs) available in the InterPro database (IPR005143), and identified those lacking a cognate AHL synthase. These LuxR solos were then analyzed regarding their taxonomical distribution, predicted functions of neighboring genes and the presence of complete AHL-QS systems in the genomes that carry them. Our analyses reveal the presence of one or multiple predicted LuxR solos in many proteobacterial genomes carrying QS domain LuxRs, some of them harboring genes for one or more AHL-QS circuits. The presence of LuxR solos in bacteria occupying diverse environments suggests potential ecological functions for these proteins beyond AHL and interkingdom signaling. Based on gene context and the conservation levels of invariant amino acids of ABD, we have classified LuxR solos into functionally meaningful groups or putative orthologs. Surprisingly, putative LuxR solos were also found in a few non-proteobacterial genomes which are not known to carry AHL-QS systems. Multiple predicted LuxR solos in the same genome appeared to have different levels of conservation of invariant amino acid residues of ABD questioning their binding to AHLs. In summary, this study provides a detailed overview of distribution of LuxR solos and their probable roles in bacteria with genome sequence information. PMID:25759807

A bioinformatic survey of distribution, conservation, and probable functions of LuxR solo regulators in bacteria.

Science.gov (United States)

Subramoni, Sujatha; Florez Salcedo, Diana Vanessa; Suarez-Moreno, Zulma R

2015-01-01

LuxR solo transcriptional regulators contain both an autoinducer binding domain (ABD; N-terminal) and a DNA binding Helix-Turn-Helix domain (HTH; C-terminal), but are not associated with a cognate N-acyl homoserine lactone (AHL) synthase coding gene in the same genome. Although a few LuxR solos have been characterized, their distributions as well as their role in bacterial signal perception and other processes are poorly understood. In this study we have carried out a systematic survey of distribution of all ABD containing LuxR transcriptional regulators (QS domain LuxRs) available in the InterPro database (IPR005143), and identified those lacking a cognate AHL synthase. These LuxR solos were then analyzed regarding their taxonomical distribution, predicted functions of neighboring genes and the presence of complete AHL-QS systems in the genomes that carry them. Our analyses reveal the presence of one or multiple predicted LuxR solos in many proteobacterial genomes carrying QS domain LuxRs, some of them harboring genes for one or more AHL-QS circuits. The presence of LuxR solos in bacteria occupying diverse environments suggests potential ecological functions for these proteins beyond AHL and interkingdom signaling. Based on gene context and the conservation levels of invariant amino acids of ABD, we have classified LuxR solos into functionally meaningful groups or putative orthologs. Surprisingly, putative LuxR solos were also found in a few non-proteobacterial genomes which are not known to carry AHL-QS systems. Multiple predicted LuxR solos in the same genome appeared to have different levels of conservation of invariant amino acid residues of ABD questioning their binding to AHLs. In summary, this study provides a detailed overview of distribution of LuxR solos and their probable roles in bacteria with genome sequence information.

A bioinformatic survey of distribution, conservation and probable functions of LuxR solo regulators in bacteria

Directory of Open Access Journals (Sweden)

Sujatha eSubramoni

2015-02-01

Full Text Available LuxR solo transcriptional regulators contain both an autoinducer binding domain (ABD; N-terminal and a DNA binding Helix-Turn-Helix domain (HTH; C-terminal, but are not associated with a cognate N-acyl homoserine lactone (AHL synthase coding gene in the same genome. Although a few LuxR solos have been characterized, their distributions as well as their role in bacterial signal perception and other processes are poorly understood. In this study we have carried out a systematic survey of distribution of all ABD containing LuxR transcriptional regulators (QS domain LuxRs available in the InterPro database (IPR005143, and identified those lacking a cognate AHL synthase. These LuxR solos were then analyzed regarding their taxonomical distribution, predicted functions of neighboring genes and the presence of complete AHL-QS systems in the genomes that carry them. Our analyses reveal the presence of one or multiple predicted LuxR solos in many proteobacterial genomes carrying QS domain LuxRs, some of them harboring genes for one or more AHL-QS circuits. The presence of LuxR solos in bacteria occupying diverse environments suggests potential ecological functions for these proteins beyond AHL and interkingdom signaling. Based on gene context and the conservation levels of invariant amino acids of ABD, we have classified LuxR solos into functionally meaningful groups or putative orthologs. Surprisingly, putative LuxR solos were also found in a few non-proteobacterial genomes which are not known to carry AHL-QS systems. Multiple predicted LuxR solos in the same genome appeared to have different levels of conservation of invariant amino acid residues of ABD questioning their binding to AHLs. In summary, this study provides a detailed overview of distribution of LuxR solos and their probable roles in bacteria with genome sequence information.

2-component heating systems

Energy Technology Data Exchange (ETDEWEB)

Radtke, W

1987-03-01

The knowledge accumulated only recently of the damage to buildings and the hazards of formaldehyde, radon and hydrocarbons has been inducing louder calls for ventilation, which, on their part, account for the fact that increasing importance is being attached to the controlled ventilation of buildings. Two-component heating systems provide for fresh air and thermal comfort in one. While the first component uses fresh air blown directly and controllably into the rooms, the second component is similar to the Roman hypocaustic heating systems, meaning that heated outer air is circulating under the floor, thus providing for hot surfaces and thermal comfort. Details concerning the two-component heating system are presented along with systems diagrams, diagrams of the heating system and tables identifying the respective costs. Descriptions are given of the two systems components, the fast heat-up, the two-component made, the change of air, heat recovery and control systems. Comparative evaluations determine the differences between two-component heating systems and other heating systems. Conclusive remarks are dedicated to energy conservation and comparative evaluations of costs. (HWJ).

Paradigms for parasite conservation.

Science.gov (United States)

Dougherty, Eric R; Carlson, Colin J; Bueno, Veronica M; Burgio, Kevin R; Cizauskas, Carrie A; Clements, Christopher F; Seidel, Dana P; Harris, Nyeema C

2016-08-01

Parasitic species, which depend directly on host species for their survival, represent a major regulatory force in ecosystems and a significant component of Earth's biodiversity. Yet the negative impacts of parasites observed at the host level have motivated a conservation paradigm of eradication, moving us farther from attainment of taxonomically unbiased conservation goals. Despite a growing body of literature highlighting the importance of parasite-inclusive conservation, most parasite species remain understudied, underfunded, and underappreciated. We argue the protection of parasitic biodiversity requires a paradigm shift in the perception and valuation of their role as consumer species, similar to that of apex predators in the mid-20th century. Beyond recognizing parasites as vital trophic regulators, existing tools available to conservation practitioners should explicitly account for the unique threats facing dependent species. We built upon concepts from epidemiology and economics (e.g., host-density threshold and cost-benefit analysis) to devise novel metrics of margin of error and minimum investment for parasite conservation. We define margin of error as the risk of accidental host extinction from misestimating equilibrium population sizes and predicted oscillations, while minimum investment represents the cost associated with conserving the additional hosts required to maintain viable parasite populations. This framework will aid in the identification of readily conserved parasites that present minimal health risks. To establish parasite conservation, we propose an extension of population viability analysis for host-parasite assemblages to assess extinction risk. In the direst cases, ex situ breeding programs for parasites should be evaluated to maximize success without undermining host protection. Though parasitic species pose a considerable conservation challenge, adaptations to conservation tools will help protect parasite biodiversity in the face of

[Regulation of heat shock gene expression in response to stress].

Science.gov (United States)

Garbuz, D G

2017-01-01

Heat shock (HS) genes, or stress genes, code for a number of proteins that collectively form the most ancient and universal stress defense system. The system determines the cell capability of adaptation to various adverse factors and performs a variety of auxiliary functions in normal physiological conditions. Common stress factors, such as higher temperatures, hypoxia, heavy metals, and others, suppress transcription and translation for the majority of genes, while HS genes are upregulated. Transcription of HS genes is controlled by transcription factors of the HS factor (HSF) family. Certain HSFs are activated on exposure to higher temperatures or other adverse factors to ensure stress-induced HS gene expression, while other HSFs are specifically activated at particular developmental stages. The regulation of the main mammalian stress-inducible factor HSF1 and Drosophila melanogaster HSF includes many components, such as a variety of early warning signals indicative of abnormal cell activity (e.g., increases in intracellular ceramide, cytosolic calcium ions, or partly denatured proteins); protein kinases, which phosphorylate HSFs at various Ser residues; acetyltransferases; and regulatory proteins, such as SUMO and HSBP1. Transcription factors other than HSFs are also involved in activating HS gene transcription; the set includes D. melanogaster GAF, mammalian Sp1 and NF-Y, and other factors. Transcription of several stress genes coding for molecular chaperones of the glucose-regulated protein (GRP) family is predominantly regulated by another stress-detecting system, which is known as the unfolded protein response (UPR) system and is activated in response to massive protein misfolding in the endoplasmic reticulum and mitochondrial matrix. A translational fine tuning of HS protein expression occurs via changing the phosphorylation status of several proteins involved in translation initiation. In addition, specific signal sequences in the 5'-UTRs of some HS

MATHEMATICAL MODELLING OF OPERATION HEAT NETWORKS IN VIEW OF HEAT LOSS

Directory of Open Access Journals (Sweden)

ZBARAZ L. I.

2016-08-01

Full Text Available Goal. In recent years, due to a significant rise in price of energy, the reduction of direct costs for heating becomes a priority. In the utilities especially important to optimization of energy heating system equipment. During transport of thermal energy in the distribution networks thermal losses occur along the length of the hydraulic pipes and the coolant pumping losses. These loss-dependence of the particular distribution network. Changing temperature and the hydraulic regime at the source necessary to achieve the minimum cost of transport for today acting tariffs for energy. Scientific novelty. The studies received law changes head to the source at the qualitative and quantitative methods of regulation. Results. A mathematical model of an extensive network of decentralized heat source heating, which are analyzed using different methods of regulating and found the best.

Interaction of regulation and innovation: Solar air heating collectors

OpenAIRE

Kramer, K.

2012-01-01

Solar Air Heating Collectors have still a very small share of 0.8% of the nominal installed capacity in the solar heating and cooling market (151.7 GWth) [1]. Although constituting a niche market, the potential of those kind of collectors to provide heat for industrial processes, processing food, room heating, air preheating, drying processes or air conditioning could be significant. However, the technical potentials of the various technological solutions are not easy to compare. Such a compa...

Numerical simulation of two phase flows in heat exchangers

International Nuclear Information System (INIS)

Grandotto Biettoli, M.

2006-04-01

The author gives an overview of his research activity since 1981. He first gives a detailed presentation of properties and equations of two-phase flows in heat exchangers, and of their mathematical and numerical investigation: semi-local equations (mass conservation, momentum conservation and energy conservation), homogenized conservation equations (mass, momentum and enthalpy conservation, boundary conditions), equation closures, discretization, resolution algorithm, computational aspects and applications. Then, he reports the works performed in the field of turbulent flows, hyperbolic methods, low Mach methods, the Neptune project, and parallel computing

77 FR 5403 - Conservation of Antarctic Animals and Plants

Science.gov (United States)

2012-02-03

... NATIONAL SCIENCE FOUNDATION 45 CFR Part 670 Conservation of Antarctic Animals and Plants AGENCY: National Science Foundation. ACTION: Final rule. SUMMARY: Pursuant to the Antarctic Conservation Act of 1978, The National Science Foundation (NSF) is amending its regulations to reflect newly designated...

Structural transitions in conserved, ordered Beclin 1 domains essential to regulating autophagy

Energy Technology Data Exchange (ETDEWEB)

Glover, Karen; Li, Yue; Mukhopadhyay, Shreya; Leuthner, Zoe; Chakravarthy, Srinivas; Colbert, Christopher L.; Sinha, Sangita C. (NDSU); (IIT)

2017-08-10

Beclin 1 (BECN1) is a key regulator of autophagy, a critical catabolic homeostasis pathway that involves sequestration of selected cytoplasmic components by multilayered vesicles called autophagosomes, followed by lysosomal fusion and degradation. BECN1 is a core component of class III phosphatidylinositol-3-kinase complexes responsible for autophagosome nucleation. Without heterologous binding partners, BECN1 forms an antiparallel homodimer via its coiled-coil domain (CCD). However, the last 16 CCD residues, composing an “overlap helix” (OH), have been crystallized in two mutually exclusive states: either as part of the CCD or packed against the C-terminal β-α repeated, autophagy-specific domain (BARAD). Here, using CD spectroscopy, isothermal titration calorimetry, and small-angle X-ray scattering, we show that in the homodimeric state, the OH transitions between these two different packing states, with the predominant state comprising the OH packed against the BARAD, contrary to expectations based on known BECN1 interactions with heterologous partners. We confirmed this observation by comparing the impact of mutating four residues that mediate packing of the OH against both the CCD and BARAD on structure and stability of the CCD, the OH+BARAD, and the two-domain CCD–BARAD. Last, we used cellular assays to demonstrate that mutation of these OH-interface residues abrogates starvation-induced up-regulation of autophagy but does not affect basal autophagy. In summary, we have identified a BECN1 helical region that transitions between packing as part of either one of two conserved domains (i.e. the CCD or the BARAD). Our findings have important implications for the relative stability of autophagy-inactive and autophagy-active BECN1 complexes.

Conservation, Preservation and Restoration in Nigerian Libraries.

Science.gov (United States)

Ojo-Igbinoba, M. E.

1991-01-01

Addresses problems involved with the conservation, preservation, and restoration of library materials in Nigeria. Topics discussed include insect pests; light, heat, and humidity; atmospheric pollution and dust; natural disasters including fire and floods; theft and vandalism; acidity of paper; binding and mending; and trained personnel. (15…

Study of the Effect of the Strategy of Heating on the Mudejar Church of Santa Maria in Ateca (Spain) for Preventive Conservation of the Altarpiece Surroundings

Science.gov (United States)

García-Diego, Fernando-Juan; Fernández-Navajas, Ángel; Beltrán, Pedro; Merello, Paloma

2013-01-01

The mudéjar church of Santa María (Ateca) is valuable for its architecture and the altarpiece contained inside. Ateca is a village with continental climate characterized by cold winters and hot summers. In this paper we are interested in analysing the effect of temperature and relative humidity (RH) changes produced by the heating system on the altarpiece. Therefore, a monitoring system of 15 temperature and 15 relative humidity sensors was installed with a recording frequency of a data point per minute. The main contribution of this paper is the quantitative study of the effect of the heating system on the thermo-hygrometric parameters using statistical techniques such as ANOVA, mean daily trajectories or bivariate plots, and the proposal of an innovative dynamic contour plot. As results, the heating system produces a substantial increase (decrease) of temperature (RH) causing an hourly variation of these physical parameters detrimental to the conservation of the altarpiece, especially in its higher areas. PMID:24064599

Large-signal, dynamic simulation of the slowpoke-3 nuclear heating reactor

International Nuclear Information System (INIS)

Tseng, C.M.; Lepp, R.M.

1983-07-01

A 2 MWt nuclear reactor, called SLOWPOKE-3, is being developed at the Chalk River Nuclear Laboratories (CRNL). This reactor, which is cooled by natural circulation, is designed to produce hot water for commercial space heating and perhaps generate some electricity in remote locations where the costs of alternate forms of energy are high. A large-signal, dynamic simulation of this reactor, without closed-loop control, was developed and implemented on a hybrid computer, using the basic equations of conservation of mass, energy and momentum. The natural circulation of downcomer flow in the pool was simulated using a special filter, capable of modelling various flow conditions. The simulation was then used to study the intermediate and long-term transient response of SLOWPOKE-3 to large disturbances, such as loss of heat sink, loss of regulation, daily load following, and overcooling of the reactor coolant. Results of the simulation show that none of these disturbances produce hazardous transients

Screening Analysis for EPACT-Covered Commercial HVAC and Water-Heating Equipment

Energy Technology Data Exchange (ETDEWEB)

Somasundaram, Sriram; Armstrong, Peter R.; Belzer, David B.; Gaines, Suzanne C.; Hadley, Donald L.; Katipumula, S.; Smith, David L.; Winiarski, David W.

2000-04-25

The Energy Policy and Conservation Act (EPCA) as amended by the Energy Policy Act of 1992 (EPACT) establishes that the U.S. Department of Energy (DOE) regulate efficiency levels of certain categories of commercial heating, cooling, and water-heating equip-ment. EPACT establishes the initial minimum efficiency levels for products falling under these categories, based on ASHRAE/IES Standard 90.1-1989 requirements. EPCA states that, if ASHRAE amends Standard 90.1-1989 efficiency levels, then DOE must establish an amended uniform national manufacturing standard at the minimum level specified in the amended Standard 90.1 and that it can establish higher efficiency levels if they would result in significant additional energy savings. Standard 90.1-1999 increases minimum efficiency levels for some of the equipment categories covered by EPCA 92. DOE conducted a screening analysis to determine the energy-savings potential for EPACT-covered products meet and exceeding these levels. This paper describes the methodology, data assumptions, and results of the analysis.

Basic feasibility study on energy conservation at Lianyuan Iron and Steel Group Co., Ltd.

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

For the purpose of conserving energy and reducing greenhouse effect gas emission, a feasibility study was carried out of the installation of energy conservation facilities at the steelworks of Lianyuan Iron and Steel Group Complex, Loudi City, Hunan Province, China. The installation of the following facilities was studied: coke dry quenching (CDQ) equipment, coal moisture control (CMC) equipment, sintering ignition furnace equipment, cooler exhaust heat recovery equipment, top pressure recovery turbine (TRT), and hot stove exhaust heat recovery equipment. As a result of the study, the energy conservation amount was 20,000 toe/y by CDQ, 2,530 toe/y by CMC, 900 toe/y by improvement of ignition furnace in the sintering process, 12,300 toe/y by sintering cooler, 13,200 toe/y by TRT, and 10,300 toe/y by hot stove exhaust heat recovery equipment. Further, the amount of greenhouse effect gas reduction was 61,022 t-CO2/y, 7,843 t-CO2/y, 2,896 t-CO2/y, 38,060 t-CO2/y, 55,295 t-CO2/y, and 40,621 t-CO2/y, respectively. In the estimation of effects vs. expenses, the sintering ignition furnace, sintering cooler exhaust heat recovery, and hot stove exhaust heat recovery indicated the comparatively favorable values. (NEDO)

Structure and function of small heat shock/alpha-crystallin proteins: established concepts and emerging ideas.

Science.gov (United States)

MacRae, T H

2000-06-01

Small heat shock/alpha-crystallin proteins are defined by conserved sequence of approximately 90 amino acid residues, termed the alpha-crystallin domain, which is bounded by variable amino- and carboxy-terminal extensions. These proteins form oligomers, most of uncertain quaternary structure, and oligomerization is prerequisite to their function as molecular chaperones. Sequence modelling and physical analyses show that the secondary structure of small heat shock/alpha-crystallin proteins is predominately beta-pleated sheet. Crystallography, site-directed spin-labelling and yeast two-hybrid selection demonstrate regions of secondary structure within the alpha-crystallin domain that interact during oligomer assembly, a process also dependent on the amino terminus. Oligomers are dynamic, exhibiting subunit exchange and organizational plasticity, perhaps leading to functional diversity. Exposure of hydrophobic residues by structural modification facilitates chaperoning where denaturing proteins in the molten globule state associate with oligomers. The flexible carboxy-terminal extension contributes to chaperone activity by enhancing the solubility of small heat shock/alpha-crystallin proteins. Site-directed mutagenesis has yielded proteins where the effect of the change on structure and function depends upon the residue modified, the organism under study and the analytical techniques used. Most revealing, substitution of a conserved arginine residue within the alpha-crystallin domain has a major impact on quaternary structure and chaperone action probably through realignment of beta-sheets. These mutations are linked to inherited diseases. Oligomer size is regulated by a stress-responsive cascade including MAPKAP kinase 2/3 and p38. Phosphorylation of small heat shock/alpha-crystallin proteins has important consequences within stressed cells, especially for microfilaments.

A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction

Science.gov (United States)

Tsai, Kuang-Lei; Sato, Shigeo; Tomomori-Sato, Chieri; Conaway, Ronald C.; Conaway, Joan W.; Asturias, Francisco J.

2013-01-01

The CDK8 kinase module (CKM) is a conserved, dissociable Mediator subcomplex whose component subunits were genetically linked to the RNA polymerase II (RNAPII) carboxy-terminal domain (CTD) and individually recognized as transcriptional repressors before Mediator was identified as a preeminent complex in eukaryotic transcription regulation. We used macromolecular electron microscopy and biochemistry to investigate the subunit organization, structure, and Mediator interaction of the Saccharomyces cerevisiae CKM. We found that interaction of the CKM with Mediator’s Middle module interferes with CTD-dependent RNAPII binding to a previously unknown Middle module CTD-binding site targeted early on in a multi-step holoenzyme formation process. Taken together, our results reveal the basis for CKM repression, clarify the origin of the connection between CKM subunits and the CTD, and suggest that a combination of competitive interactions and conformational changes that facilitate holoenzyme formation underlie the Mediator mechanism. PMID:23563140

Energy conservation in coal conversion. Final report, September 15, 1977--September 1, 1978. Selected case studies and conservation methodologies

Energy Technology Data Exchange (ETDEWEB)

Purcupile, J.C.

1978-09-01

The purpose of this study is to apply the methodologies developed in the Energy Conservation in Coal Conversion August, 1977 Progress Report - Contract No. EY77S024196 - to an energy efficient, near-term coal conversion process design, and to develop additional, general techniques for studying energy conservation and utilization in coal conversion processes. The process selected for study was the Ralph M. Parsons Company of Pasadena, California ''Oil/Gas Complex, Conceptual Design/Economic Analysis'' as described in R and D Report No. 114 - Interim Report No. 4, published March, 1977, ERDA Contract No. E(49-18)-1975. Thirteen papers representing possible alternative methods of energy conservation or waste heat utilization have been entered individually into EDB and ERA. (LTN)

Effects of the regulating energy levy and energy tariffs on the cost effectiveness of energy efficient production of heat and cold

International Nuclear Information System (INIS)

2000-01-01

With respect to the title subject collective and stand-alone systems for house and office buildings were analyzed. For houses a high-efficiency boiler as reference system, and individual micro-cogeneration unit, an individual electric heat pump with a collective aquifer as heat source, an individual gas heat pump with outside air as a heat source, a collective cogeneration system, and a collective energy plant with cogeneration and an electric heat pump. For office buildings a high-efficiency boiler and a cooling machine as a reference system, an individual electric heat pump with an individual aquifer as a heat source, cold storage, collective cogeneration, and a collective energy plant with cogeneration and an electric heat pump. Also an overview is given of the changes that are taking place in the tariffs for natural gas, e.g. the use of so-called Commodity Services. Finally, the impact on prices of natural gas and electricity of the fact that the tax-free threshold of the regulating energy levy (REB, abbreviated in Dutch) will disappear is investigated. 5 refs

Optimization of Heat Exchangers

International Nuclear Information System (INIS)

Catton, Ivan

2010-01-01

The objective of this research is to develop tools to design and optimize heat exchangers (HE) and compact heat exchangers (CHE) for intermediate loop heat transport systems found in the very high temperature reator (VHTR) and other Generation IV designs by addressing heat transfer surface augmentation and conjugate modeling. To optimize heat exchanger, a fast running model must be created that will allow for multiple designs to be compared quickly. To model a heat exchanger, volume averaging theory, VAT, is used. VAT allows for the conservation of mass, momentum and energy to be solved for point by point in a 3 dimensional computer model of a heat exchanger. The end product of this project is a computer code that can predict an optimal configuration for a heat exchanger given only a few constraints (input fluids, size, cost, etc.). As VAT computer code can be used to model characteristics (pumping power, temperatures, and cost) of heat exchangers more quickly than traditional CFD or experiment, optimization of every geometric parameter simultaneously can be made. Using design of experiment, DOE and genetric algorithms, GE, to optimize the results of the computer code will improve heat exchanger design.

The Fourier law in a momentum-conserving chain

NARCIS (Netherlands)

Giardinà, C.; Kurchan, J.

2005-01-01

We introduce a family of models for heat conduction with and without momentum conservation. They are analytically solvable in the high temperature limit and can also be efficiently simulated. In all cases the Fourier law is verified in one dimension.

Conservation heating for a museum environment in a monumental building

NARCIS (Netherlands)

Neuhaus, E.; Schellen, H.L.

2007-01-01

For the conservation of an important museum collection in a historic building a better controlled indoor climate may be necessary. One of the most important factors is controlling relative humidity. Museum collections often are part of the interior of a historic building. In most cases the

Heat storage in Asian elephants during submaximal exercise: behavioral regulation of thermoregulatory constraints on activity in endothermic gigantotherms.

Science.gov (United States)

Rowe, M F; Bakken, G S; Ratliff, J J; Langman, V A

2013-05-15

Gigantic size presents both opportunities and challenges in thermoregulation. Allometric scaling relationships suggest that gigantic animals have difficulty dissipating metabolic heat. Large body size permits the maintenance of fairly constant core body temperatures in ectothermic animals by means of gigantothermy. Conversely, gigantothermy combined with endothermic metabolic rate and activity likely results in heat production rates that exceed heat loss rates. In tropical environments, it has been suggested that a substantial rate of heat storage might result in a potentially lethal rise in core body temperature in both elephants and endothermic dinosaurs. However, the behavioral choice of nocturnal activity might reduce heat storage. We sought to test the hypothesis that there is a functionally significant relationship between heat storage and locomotion in Asian elephants (Elephas maximus), and model the thermoregulatory constraints on activity in elephants and a similarly sized migratory dinosaur, Edmontosaurus. Pre- and post-exercise (N=37 trials) measurements of core body temperature and skin temperature, using thermography were made in two adult female Asian elephants at the Audubon Zoo in New Orleans, LA, USA. Over ambient air temperatures ranging from 8 to 34.5°C, when elephants exercised in full sun, ~56 to 100% of active metabolic heat production was stored in core body tissues. We estimate that during nocturnal activity, in the absence of solar radiation, between 5 and 64% of metabolic heat production would be stored in core tissues. Potentially lethal rates of heat storage in active elephants and Edmontosaurus could be behaviorally regulated by nocturnal activity.

Industrial waste heat utilization for low temperature district heating

International Nuclear Information System (INIS)

Fang, Hao; Xia, Jianjun; Zhu, Kan; Su, Yingbo; Jiang, Yi

2013-01-01

Large quantities of low grade waste heat are discharged into the environment, mostly via water evaporation, during industrial processes. Putting this industrial waste heat to productive use can reduce fossil fuel usage as well as CO 2 emissions and water dissipation. The purpose of this paper is to propose a holistic approach to the integrated and efficient utilization of low-grade industrial waste heat. Recovering industrial waste heat for use in district heating (DH) can increase the efficiency of the industrial sector and the DH system, in a cost-efficient way defined by the index of investment vs. carbon reduction (ICR). Furthermore, low temperature DH network greatly benefits the recovery rate of industrial waste heat. Based on data analysis and in-situ investigations, this paper discusses the potential for the implementation of such an approach in northern China, where conventional heat sources for DH are insufficient. The universal design approach to industrial-waste-heat based DH is proposed. Through a demonstration project, this approach is introduced in detail. This study finds three advantages to this approach: (1) improvement of the thermal energy efficiency of industrial factories; (2) more cost-efficient than the traditional heating mode; and (3) CO 2 and pollutant emission reduction as well as water conservation. -- Highlights: •We review situation of industrial waste heat recovery with a global perspective. •We present a way to analyze the potential to utilize industrial waste heat for DH. •Northern China has huge potential for using low-grade industrial waste heat for DH. •A demonstration project is introduced using the universal approach we propose. •It proves huge benefits for factories, heat-supply companies and the society

Italian energy conservation laws: Implementation problems

International Nuclear Information System (INIS)

Anon.

1993-01-01

Italian energy conservation Law No. 9 was designed to reduce Italy's worrisome 82% dependency on foreign energy supplies by encouraging the development and use of renewable energy sources, fuel diversification and auto-production/cogeneration by private industry. Law No. 10 was intended to promote energy conservation initiatives especially with regard to the efficient use of energy for space heating in public buildings. Both of these legal incentives have encountered great difficulties in implementation due to the inability of the Government to provide the necessary timely and sufficient start-up funds, as well as, due to the excessive bureaucratism that was built into the administrative procedures

The stress-induced heat shock protein 70.3 expression is regulated by a dual-component mechanism involving alternative polyadenylation and HuR.

Science.gov (United States)

Kraynik, Stephen M; Gabanic, Andrew; Anthony, Sarah R; Kelley, Melissa; Paulding, Waltke R; Roessler, Anne; McGuinness, Michael; Tranter, Michael

2015-06-01

Heat shock protein 70.3 (Hsp70.3) expression increases in response to cellular stress and plays a cytoprotective role. We have previously shown that Hsp70.3 expression is controlled through coordinated post-transcriptional regulation by miRNAs and alternative polyadenylation (APA), and APA-mediated shortening of the Hsp70.3 3'-UTR facilitates increased protein expression. A stress-induced increase in Hsp70.3 mRNA and protein expression is accompanied by alternative polyadenylation (APA)-mediated truncation of the 3'UTR of the Hsp70.3 mRNA transcript. However, the role that APA plays in stress-induced expression of Hsp70.3 remains unclear. Our results show that APA-mediated truncation of the Hsp70.3 3'UTR increases protein expression through enhanced polyribosome loading. Additionally, we demonstrate that the RNA binding protein HuR, which has been previously shown to play a role in mediating APA, is necessary for heat shock mediated increase in Hsp70.3 mRNA and protein. However, it is somewhat surprising to note that HuR does not play a role in APA of the Hsp70.3 mRNA, and these two regulatory events appear to be mutually exclusive regulators of Hsp70.3 expression. These results not only provide important insight to the regulation of stress response genes following heat shock, but also contribute an enhanced understanding of how alternative polyadenylation contributes to gene regulation. Copyright © 2015 Elsevier B.V. All rights reserved.

Energy conservation measures adopted at Heavy Water Plant, Manuguru

International Nuclear Information System (INIS)

Gupta, R.V.; Venugopal, M.

1997-01-01

The importance of conservation of energy is well recognised all over the world as the world reserves of fossil fuels will eventually run out depending on the rate of their use. This paper deals with various energy conservation schemes adopted at Heavy Water Plant, Manuguru (HWPM). Most energy conservation measures offer large financial saving with very short pay back periods. This fact has been well recognised by the management of HWPM as well as Heavy Water Board and their wholehearted and enthusiastic approach to energy conservation and energy management yielded very good results in reducing the operating cost. The process of energy conservation is not a one time exercise. Persistent efforts are on to identify the areas like condition of heat exchangers, margins in control valves, steam and condensate leakages etc. for further reduction in energy consumption

Development of platform to compare different wall heat transfer packages for system analysis codes

International Nuclear Information System (INIS)

Kim, Min-Gil; Lee, Won Woong; Lee, Jeong Ik; Shin, Sung Gil

2016-01-01

System thermal hydraulic (STH) analysis code is used for analyzing and evaluating the safety of a designed nuclear system. The system thermal hydraulic analysis code typically solves mass, momentum and energy conservation equations for multiple phases with sets of selected empirical constitutive equations to close the problem. Several STH codes are utilized in academia, industry and regulators, such as MARS-KS, SPACE, RELAP5, COBRA-TF, TRACE, and so on. Each system thermal hydraulic code consists of different sets of governing equations and correlations. However, the packages and sets of correlations of each code are not compared quantitatively yet. Wall heat transfer mode transition maps of SPACE and MARS-KS have a little difference for the transition from wall nucleate heat transfer mode to wall film heat transfer mode. Both codes have the same heat transfer packages and correlations in most region except for wall film heat transfer mode. Most of heat transfer coefficients calculated for the range of selected variables of SPACE are the same with those of MARS-KS. For the intervals between 500K and 540K of wall temperature, MARS-KS selects the wall film heat transfer mode and Bromley correlation but SPACE select the wall nucleate heat transfer mode and Chen correlation. This is because the transition from nucleate boiling to film boiling of MARS-KS is earlier than SPACE. More detailed analysis of the heat transfer package and flow regime package will be followed in the near future

Impact of local empowerment on conservation practices in a highly developed country

OpenAIRE

Engen, Sigrid; Hausner, Vera Helene

2017-01-01

Source at http://dx.doi.org/10.1111/conl.12369 Community-based conservation, where local decision makers are responsible for balancing conservation and development, is often preferred to exclusion- ary conservation that prioritizes use-limitation through strict regulation. Un- raveling the evidence for conservation impact of different governance regimes is challenging. Focusing on conservation practices before and after a reform can provide an early indication of behaviora...

Heat pipes as perspective base elements of heat recovery in heat supply and ventilating systems

Directory of Open Access Journals (Sweden)

Matveev Andrey

2017-01-01

Full Text Available Thermotechnical characteristics of heat pipes are considered as high-efficient heat-transfer devices, which can provide energy-saving technologies for heat supply and ventilating systems and for different branches of industry. Thermotechnical and working (”performance capability” characteristics of heat pipes are investigated. By ”performance capability” of heat pipes and heat-transfer devices on heat pipes we mean the system state, where it can perform set functions and keep parameter values (thermal power, conductivity, thermal resistance, heat-transfer coefficient, temperature level and differential, etc. within the regulations of standardized specifications. The article presents theoretical and experimental methods of «gaslock» length determination on noncondensable gases during long-lasting tests of ammonia heat pipes made of aluminum shape АS – КRА 7.5 – R1 (alloy АD – 31. The paper gives results of research of thermotechnical characteristics of heat pipes in horizontal and vertical states (separate and as a set part while using different systems of thermal insulation. The obtained results of thermotechnical and resource tests show the advantages of ammonia heat pipes as basic elements for heat exchanger design in heating and ventilation systems.

Conservation of AtTZF1, AtTZF2 and AtTZF3 homolog gene regulation by salt stress in evolutionarily distant plant species

Directory of Open Access Journals (Sweden)

Fabio eD'Orso

2015-06-01

Full Text Available Arginine-rich tandem zinc-finger proteins (RR-TZF participate in a wide range of plant developmental processes and adaptive responses to abiotic stress, such as cold, salt and drought. This study investigates the conservation of the genes AtTZF1-5 at the level of their sequences and expression across plant species. The genomic sequences of the two RR-TZF genes TdTZF1-A and TdTZF1-B were isolated in durum wheat and assigned to chromosomes 3A and 3B, respectively. Sequence comparisons revealed that they encode proteins that are highly homologous to AtTZF1, AtTZF2 and AtTZF3. The expression profiles of these RR-TZF durum wheat and Arabidopsis proteins support a common function in the regulation of seed germination and responses to abiotic stress. In particular, analysis of plants with attenuated and overexpressed AtTZF3 indicate that AtTZF3 is a negative regulator of seed germination under conditions of salt stress. Finally, comparative sequence analyses establish that the RR-TZF genes are encoded by lower plants, including the bryophyte Physcomitrella patens and the alga Chlamydomonas reinhardtii. The regulation of the Physcomitrella AtTZF1-2-3-like genes by salt stress strongly suggests that a subgroup of the RR-TZF proteins has a function that has been conserved throughout evolution.

Energy Conservation Analysis and Control of Hybrid Active Semiactive Suspension with Three Regulating Damping Levels

Directory of Open Access Journals (Sweden)

Long Chen

2016-01-01

Full Text Available Active suspension has not been popularized for high energy consumption. To address this issue, this paper introduces the concept of a new kind of suspension. The linear motor is considered to be integrated into an adjustable shock absorber to form the hybrid active semiactive suspension (HASAS. To realize the superiority of HASAS, its energy consumption and regeneration mechanisms are revealed. And the system controller which is composed of linear quadratic regulator (LQR controller, mode decision and switch controller, and the sliding mode control based thrust controller is developed. LQR controller is designed to maintain the suspension control objectives, while mode decision and switch controller decides the optimal damping level to tune motor thrust. The thrust controller ensures motor thrust tracking. An adjustable shock absorber with three regulating levels to be used in HASAS is trial produced and tested to obtain its working characteristics. Finally, simulation analysis is made with the experimental three damping characteristics. The impacts of adjustable damping on the motor force and energy consumption are investigated. Simulation results demonstrate the advantages of HASAS in energy conservation with various suspension control objectives. Even self-powered active control and energy regenerated to the power source can be realized.

Heat transfer analysis of underground U-type heat exchanger of ground source heat pump system.

Science.gov (United States)

Pei, Guihong; Zhang, Liyin

2016-01-01

Ground source heat pumps is a building energy conservation technique. The underground buried pipe heat exchanging system of a ground source heat pump (GSHP) is the basis for the normal operation of an entire heat pump system. Computational-fluid-dynamics (CFD) numerical simulation software, ANSYS-FLUENT17.0 have been performed the calculations under the working conditions of a continuous and intermittent operation over 7 days on a GSHP with a single-well, single-U and double-U heat exchanger and the impact of single-U and double-U buried heat pipes on the surrounding rock-soil temperature field and the impact of intermittent operation and continuous operation on the outlet water temperature. The influence on the rock-soil temperature is approximately 13 % higher for the double-U heat exchanger than that of the single-U heat exchanger. The extracted energy of the intermittent operation is 36.44 kw·h higher than that of the continuous mode, although the running time is lower than that of continuous mode, over the course of 7 days. The thermal interference loss and quantity of heat exchanged for unit well depths at steady-state condition of 2.5 De, 3 De, 4 De, 4.5 De, 5 De, 5.5 De and 6 De of sidetube spacing are detailed in this work. The simulation results of seven working conditions are compared. It is recommended that the side-tube spacing of double-U underground pipes shall be greater than or equal to five times of outer diameter (borehole diameter: 180 mm).

Dynamic behavior of district heating systems

International Nuclear Information System (INIS)

Kunz, J.

1994-01-01

The goal of this study is to develop a simulation model of a hot water system taking into account the time dependent phenomena which are important for the operational management of such a system. A state of the art literature review has shown that there is no such model considering all parts from the generation of the heat at the plant to its consumption in the connected buildings so far. First, an exhaustive list of all dynamic phenomena occurring in district heating systems has been drawn and analyzed. Considering this list, this thesis proposes that a model which satisfies the criteria listed above can be developed by superposing four sub-models which are a dynamic model of the heat generation plant, a steady state model of the hydraulic calculation of the distribution network, a dynamic model of the thermal behavior of the network and a dynamic model of the heat consumers. The development of the four sub-models starts from the fundamental conservation equations for fluid systems, i.e. the conservation of mass, momentum and energy. The transformations of those general equations into simple calculation formulas show and justify the hypotheses made in the modeling process. The heat generation plant model itself is a set of sub-models: the models for steam boilers, hot water boilers and heat accumulators which take account of the dynamic evolution of the water temperature by a simple form of the energy conservation equation, as well as the steady state models for circulation pumps and pressurizers. Since the velocities in the network pipes are small, a consideration of steady states is adopted. A network model allowing to calculate the hydraulic variables in every point is adopted from the graph theory. The pressures and flow rates in the network are calculated at discrete time steps and they are considered to be constant for the duration between the time steps. (author) figs., tabs., refs

Electricity Market Optimization of Heat Pump Portfolio

DEFF Research Database (Denmark)

Biegel, Benjamin; Andersen, Palle; Pedersen, Tom S.

2013-01-01

We consider a portfolio of domestic heat pumps controlled by an aggregator. The aggregator is able to adjust the consumption of the heat pumps without affecting the comfort in the houses and uses this ability to shift the main consumption to hours with low electricity prices. Further......, the aggregator is able to place upward and downward regulating bids in the regulating power market based on the consumption flexibility. A simulation is carried out based on data from a Danish domestic heat pump project, historical spot prices, regulating power prices, and spot price predictions. The simulations...

41 CFR 101-25.112 - Energy conservation policy.

Science.gov (United States)

2010-07-01

... Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 25-GENERAL 25.1... procurement and property management documents reflect the policy set forth in paragraph (b) of this section... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Energy conservation...

The implications of RCRA [Resource Conservation and Recovery Act] regulation for the disposal of transuranic and high-level waste

International Nuclear Information System (INIS)

Sigmon, C.F.; Sharples, F.E.; Smith, E.D.

1988-01-01

In May of 1987 the Department of Energy (DOE) published a rule interpreting the definition of ''byproduct'' under the Atomic Energy Act. This byproduct rule clarified the role of the Resource Conservation and Recovery Act (RCRA) in the regulation of DOE's radioactive waste management activities. According to the rule, only the radioactive portion of DOE's mixed radioactive and hazardous waste (mixed waste), including mixed transuranic (TRU) and high-level waste (HLW), is exempt from RCRA under the byproduct exemption. The portion of a waste that is hazardous as defined by RCRA is subject to full regulation under RCRA. Because the radioactive and hazardous portions of m any, if not most, DOE wastes are likely to be inseparable, the rule in effect makes most mixed wastes subject to dual regulation. The potential application of RCRA to facilities such as the Waste Isolation Pilot Plant (WIPP) and the HLW repository creates unique challenges for both the DOE and regulatory authorities. Strategies must be developed to assure compliance with RCRA without either causing excessive administrative burdens or abandoning the goal of minimizing radiation exposure. This paper will explore some of the potential regulatory options for and recent trends in the regulation of TRU and HLW under RCRA

The Energy Conservation Guide 98/99; ENOEK guiden 99

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-07-01

Norwegians have the world's largest electricity consumption per capita. This booklet aims to advice house owners on efficient use of energy. The main sections discuss the concept of energy conservation in general, heating, stoves and fireplaces, central heating, insulation and sealing, windows, hot water, water saving, lighting, domestic appliances, ventilation, outdoor facilities, and finally gives some tips on investments and profitability and how to obtain expert advice. The booklet is profusely illustrated.

Solar thermal heating and cooling. A bibliography with abstracts

Science.gov (United States)

Arenson, M.

1979-01-01

This bibliographic series cites and abstracts the literature and technical papers on the heating and cooling of buildings with solar thermal energy. Over 650 citations are arranged in the following categories: space heating and cooling systems; space heating and cooling models; building energy conservation; architectural considerations, thermal load computations; thermal load measurements, domestic hot water, solar and atmospheric radiation, swimming pools; and economics.

Conserved Transcriptional Regulatory Programs Underlying Rice and Barley Germination

Science.gov (United States)

Lin, Li; Tian, Shulan; Kaeppler, Shawn; Liu, Zongrang; An, Yong-Qiang (Charles)

2014-01-01

Germination is a biological process important to plant development and agricultural production. Barley and rice diverged 50 million years ago, but share a similar germination process. To gain insight into the conservation of their underlying gene regulatory programs, we compared transcriptomes of barley and rice at start, middle and end points of germination, and revealed that germination regulated barley and rice genes (BRs) diverged significantly in expression patterns and/or protein sequences. However, BRs with higher protein sequence similarity tended to have more conserved expression patterns. We identified and characterized 316 sets of conserved barley and rice genes (cBRs) with high similarity in both protein sequences and expression patterns, and provided a comprehensive depiction of the transcriptional regulatory program conserved in barley and rice germination at gene, pathway and systems levels. The cBRs encoded proteins involved in a variety of biological pathways and had a wide range of expression patterns. The cBRs encoding key regulatory components in signaling pathways often had diverse expression patterns. Early germination up-regulation of cell wall metabolic pathway and peroxidases, and late germination up-regulation of chromatin structure and remodeling pathways were conserved in both barley and rice. Protein sequence and expression pattern of a gene change quickly if it is not subjected to a functional constraint. Preserving germination-regulated expression patterns and protein sequences of those cBRs for 50 million years strongly suggests that the cBRs are functionally significant and equivalent in germination, and contribute to the ancient characteristics of germination preserved in barley and rice. The functional significance and equivalence of the cBR genes predicted here can serve as a foundation to further characterize their biological functions and facilitate bridging rice and barley germination research with greater confidence. PMID

Translation Initiation from Conserved Non-AUG Codons Provides Additional Layers of Regulation and Coding Capacity

Directory of Open Access Journals (Sweden)

Ivaylo P. Ivanov

2017-06-01

Full Text Available Neurospora crassa cpc-1 and Saccharomyces cerevisiae GCN4 are homologs specifying transcription activators that drive the transcriptional response to amino acid limitation. The cpc-1 mRNA contains two upstream open reading frames (uORFs in its >700-nucleotide (nt 5′ leader, and its expression is controlled at the level of translation in response to amino acid starvation. We used N. crassa cell extracts and obtained data indicating that cpc-1 uORF1 and uORF2 are functionally analogous to GCN4 uORF1 and uORF4, respectively, in controlling translation. We also found that the 5′ region upstream of the main coding sequence of the cpc-1 mRNA extends for more than 700 nucleotides without any in-frame stop codon. For 100 cpc-1 homologs from Pezizomycotina and from selected Basidiomycota, 5′ conserved extensions of the CPC1 reading frame are also observed. Multiple non-AUG near-cognate codons (NCCs in the CPC1 reading frame upstream of uORF2, some deeply conserved, could potentially initiate translation. At least four NCCs initiated translation in vitro. In vivo data were consistent with initiation at NCCs to produce N-terminally extended N. crassa CPC1 isoforms. The pivotal role played by CPC1, combined with its translational regulation by uORFs and NCC utilization, underscores the emerging significance of noncanonical initiation events in controlling gene expression.

Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans.

Directory of Open Access Journals (Sweden)

Michelle D Leach

Full Text Available Eukaryotic cells have evolved mechanisms to sense and adapt to dynamic environmental changes. Adaptation to thermal insults, in particular, is essential for their survival. The major fungal pathogen of humans, Candida albicans, is obligately associated with warm-blooded animals and hence occupies thermally buffered niches. Yet during its evolution in the host it has retained a bona fide heat shock response whilst other stress responses have diverged significantly. Furthermore the heat shock response is essential for the virulence of C. albicans. With a view to understanding the relevance of this response to infection we have explored the dynamic regulation of thermal adaptation using an integrative systems biology approach. Our mathematical model of thermal regulation, which has been validated experimentally in C. albicans, describes the dynamic autoregulation of the heat shock transcription factor Hsf1 and the essential chaperone protein Hsp90. We have used this model to show that the thermal adaptation system displays perfect adaptation, that it retains a transient molecular memory, and that Hsf1 is activated during thermal transitions that mimic fever. In addition to providing explanations for the evolutionary conservation of the heat shock response in this pathogen and the relevant of this response to infection, our model provides a platform for the analysis of thermal adaptation in other eukaryotic cells.

Effect of patchouli alcohol on the regulation of heat shock-induced oxidative stress in IEC-6 cells.

Science.gov (United States)

Liu, Xiaoxi; Jiang, Linshu; Liu, Fenghua; Chen, Yuping; Xu, Lei; Li, Deyin; Ma, Yunfei; Li, Huanrong; Xu, Jianqin

2016-08-01

Purpose Patchouli alcohol (PA) is used to treat gastrointestinal dysfunction. The purpose of this study was to ascertain the function of PA in the regulated process of oxidative stress in rat intestinal epithelial cells (IEC-6). Materials and methods Oxidative stress was stimulated by exposing IEC-6 cells to heat shock (42 °C for 3 h). IEC-6 cells in treatment groups were pretreated with various concentrations of PA (10, 40, and 80 ng/mL) for 3 h before heat shock. Results Heat shock caused damage to the morphology of IEC-6 cells, and increased reactive oxygen species (ROS) level and malondialdehyde (MDA) content. Moreover, mRNA and protein expression by target genes related to oxidative stress in heat shock were also altered. Specifically, the mRNA expression by HSP70, HSP90, GSH-px, NRF2 nd HO-1were all increased, and Nrf2 and Keap1 protein expression were increased after heat shock. However, pretreatment with PA weakened the level of damage to the cellular morphology, and decreased the MDA content caused by heat shock, indicating PA had cytoprotective activities. Pretreatment with PA at high dose significantly increased generation of intracellular ROS. Compared with the heat shock group alone, PA pretreatment significantly decreased the mRNA expression by HSP70, HSP90, SOD, CAT, GSH-px, KEAP1 and HO-1. Furthermore, the high dose of PA significantly increased Nrf2 protein expression, while both the intermediate and high dose of PA significantly increased HO-1 protein expression. Conclusion Heat-shock-induced oxidative stress in IEC-6 cells, and PA could alleviate the Nrf2-Keap1 cellular oxidative stress responses.

Geothermal heating saves energy

International Nuclear Information System (INIS)

Romsaas, Tor

2003-01-01

The article reviews briefly a pioneer project for a construction area of 200000 m''2 with residences, business complexes, a hotel and conference centre and a commercial college in Oslo. The energy conservation potential is estimated to be about 60-70 % compared to direct heating with oil, gas or electricity as sources. There will also be substantial reduction in environmentally damaging emissions. The proposed energy central combines geothermal energy sources with heat pump technology, utilises water as energy carrier and uses terrestrial wells for energy storage. A cost approximation is presented

Proceedings of the 8. Brazilian congress on energy: energy policy, regulation and sustainable development. v. 2: energy planning and policy, energy conservation and rational use

International Nuclear Information System (INIS)

1999-01-01

The theme energy policy, regulation and sustainable development chosen for the 8. Brazilian congress on energy to be held in Rio de Janeiro from 30 November of 1999 to 02 December of 1999, specifically means the contribution of energy to a satisfactory quality of life for everyone. Within such a context, the congress technical programme theme has been structured around six different divisions: energy, environment and development; energy sector regulation; energy policy and planning; technology innovation; energy conservation; and renewable energy sources and rural areas energy supply

Holographic heat current as Noether current

Science.gov (United States)

Liu, Hai-Shan; Lü, H.; Pope, C. N.

2017-09-01

We employ the Noether procedure to derive a general formula for the radially conserved heat current in AdS planar black holes with certain transverse and traceless perturbations, for a general class of gravity theories. For Einstein gravity, the general higher-order Lovelock gravities and also a class of Horndeski gravities, we derive the boundary stress tensor and show that the resulting boundary heat current matches precisely the bulk Noether current.

An always reliable energy source. 100 years unexploited: Heat from wastewater in the pump station Mannheim Ochsenpferch; Eine stets zuverlaessige Energiequelle. 100 Jahre ungenutzt. Waerme aus Abwasser im Pumpwerk Mannheim-Ochsenpferch

Energy Technology Data Exchange (ETDEWEB)

Koenig, Klaus W.

2012-12-15

Energy price increases, financial supports as well as exacerbated regulation on energy conservation increasingly makes the heat from waste water attractive and ensures a rapidly increasing number of projects. The pump station Ochsenpferch is the first reference object in Mannheim (Federal Republic of Germany). This pump station is a public station according to a standard being established in 2019 presumably.

Modeling and impacts of the latent heat of phase change and specific heat for phase change materials

Science.gov (United States)

Scoggin, J.; Khan, R. S.; Silva, H.; Gokirmak, A.

2018-05-01

We model the latent heats of crystallization and fusion in phase change materials with a unified latent heat of phase change, ensuring energy conservation by coupling the heat of phase change with amorphous and crystalline specific heats. We demonstrate the model with 2-D finite element simulations of Ge2Sb2Te5 and find that the heat of phase change increases local temperature up to 180 K in 300 nm × 300 nm structures during crystallization, significantly impacting grain distributions. We also show in electrothermal simulations of 45 nm confined and 10 nm mushroom cells that the higher amorphous specific heat predicted by this model increases nucleation probability at the end of reset operations. These nuclei can decrease set time, leading to variability, as demonstrated for the mushroom cell.

Model for Determining Geographical Distribution of Heat Saving Potentials in Danish Building Stock

DEFF Research Database (Denmark)

Petrovic, Stefan; Karlsson, Kenneth Bernard

2014-01-01

Since the global oil crisis in the 1970s, Denmark has followed a path towards energy independency by continuously improving its energy efficiency and energy conservation. Energy efficiency was mainly tackled by introducing a high number of combined heat and power plants in the system, while energy...... conservation was predominantly approached by implementing heat saving measures. Today, with the goal of 100% renewable energy within the power and heat sector by the year 2035, reductions in energy demand for space heating and the preparation of domestic hot water remain at the top of the agenda in Denmark....... A highly detailed model for determining heat demand, possible heat savings and associated costs in the Danish building stock is presented. Both scheduled and energy-saving renovations until year 2030 have been analyzed. The highly detailed GIS-based heat atlas for Denmark is used as a container for storing...

Module-based analysis of robustness tradeoffs in the heat shock response system.

Directory of Open Access Journals (Sweden)

Hiroyuki Kurata

2006-07-01

Full Text Available Biological systems have evolved complex regulatory mechanisms, even in situations where much simpler designs seem to be sufficient for generating nominal functionality. Using module-based analysis coupled with rigorous mathematical comparisons, we propose that in analogy to control engineering architectures, the complexity of cellular systems and the presence of hierarchical modular structures can be attributed to the necessity of achieving robustness. We employ the Escherichia coli heat shock response system, a strongly conserved cellular mechanism, as an example to explore the design principles of such modular architectures. In the heat shock response system, the sigma-factor sigma32 is a central regulator that integrates multiple feedforward and feedback modules. Each of these modules provides a different type of robustness with its inherent tradeoffs in terms of transient response and efficiency. We demonstrate how the overall architecture of the system balances such tradeoffs. An extensive mathematical exploration nevertheless points to the existence of an array of alternative strategies for the existing heat shock response that could exhibit similar behavior. We therefore deduce that the evolutionary constraints facing the system might have steered its architecture toward one of many robustly functional solutions.

Competition within the energy sector and State regulation

International Nuclear Information System (INIS)

Larsen, A.; Jess Olsen, O.

1995-10-01

It is presumed that energy markets will be liberalized. Questions discussed are how the Danish electricity and gas sectors are to be re-regulated in order to ensure that this goal is reached in the most satisfactory manner (cheaper energy supply under competitive conditions) and whether there will be a conflict between the goal of liberalization and the environmental goals of clean technology and energy conservation. It is suggested that a compulsory splitting up of the two regional power associations in Denmark should not be necessary. Transmission and distribution must continue to be regulated as these are natural monopolies not compatible with competition. District heating will still be a monopoly and its prices must be closely regulated to prevent soaring. The opening up of the European gas market to competition will threaten Danish energy utilities. The increasing compulsory use of natural gas in cogeneration plants to politically determined high prices is not sustainable under competitive conditions. Energy saving activities should not be affected. Energy surcharges are attractive measures on a liberalized market. The regulation of competition ought to be incorporated explicitly as a restriction in the Ministry of Energy's energy policy regulation. Energy utilities could be excluded from participation in price setting. International regulation of competition will demand a clarification of the separation of regulatory competence between the member states and the European Commission. It will also be necessary to adjust the Danish regulation of the electricity sector to the future Scandinavian system. (AB) 77 refs

Profiling conserved biological pathways in Autosomal Dominant Polycystic Kidney Disorder (ADPKD) to elucidate key transcriptomic alterations regulating cystogenesis: A cross-species meta-analysis approach.

Science.gov (United States)

Chatterjee, Shatakshee; Verma, Srikant Prasad; Pandey, Priyanka

2017-09-05

Initiation and progression of fluid filled cysts mark Autosomal Dominant Polycystic Kidney Disease (ADPKD). Thus, improved therapeutics targeting cystogenesis remains a constant challenge. Microarray studies in single ADPKD animal models species with limited sample sizes tend to provide scattered views on underlying ADPKD pathogenesis. Thus we aim to perform a cross species meta-analysis to profile conserved biological pathways that might be key targets for therapy. Nine ADPKD microarray datasets on rat, mice and human fulfilled our study criteria and were chosen. Intra-species combined analysis was performed after considering removal of batch effect. Significantly enriched GO biological processes and KEGG pathways were computed and their overlap was observed. For the conserved pathways, biological modules and gene regulatory networks were observed. Additionally, Gene Set Enrichment Analysis (GSEA) using Molecular Signature Database (MSigDB) was performed for genes found in conserved pathways. We obtained 28 modules of significantly enriched GO processes and 5 major functional categories from significantly enriched KEGG pathways conserved in human, mice and rats that in turn suggest a global transcriptomic perturbation affecting cyst - formation, growth and progression. Significantly enriched pathways obtained from up-regulated genes such as Genomic instability, Protein localization in ER and Insulin Resistance were found to regulate cyst formation and growth whereas cyst progression due to increased cell adhesion and inflammation was suggested by perturbations in Angiogenesis, TGF-beta, CAMs, and Infection related pathways. Additionally, networks revealed shared genes among pathways e.g. SMAD2 and SMAD7 in Endocytosis and TGF-beta. Our study suggests cyst formation and progression to be an outcome of interplay between a set of several key deregulated pathways. Thus, further translational research is warranted focusing on developing a combinatorial therapeutic

TaHsfA6f is a transcriptional activator that regulates a suite of heat stress protection genes in wheat (Triticum aestivum L.) including previously unknown Hsf targets.

Science.gov (United States)

Xue, Gang-Ping; Drenth, Janneke; McIntyre, C Lynne

2015-02-01

Heat stress is a significant environmental factor adversely affecting crop yield. Crop adaptation to high-temperature environments requires transcriptional reprogramming of a suite of genes involved in heat stress protection. This study investigated the role of TaHsfA6f, a member of the A6 subclass of heat shock transcription factors, in the regulation of heat stress protection genes in Triticum aestivum (bread wheat), a poorly understood phenomenon in this crop species. Expression analysis showed that TaHsfA6f was expressed constitutively in green organs but was markedly up-regulated during heat stress. Overexpression of TaHsfA6f in transgenic wheat using a drought-inducible promoter resulted in up-regulation of heat shock proteins (HSPs) and a number of other heat stress protection genes that included some previously unknown Hsf target genes such as Golgi anti-apoptotic protein (GAAP) and the large isoform of Rubisco activase. Transgenic wheat plants overexpressing TaHsfA6f showed improved thermotolerance. Transactivation assays showed that TaHsfA6f activated the expression of reporter genes driven by the promoters of several HSP genes (TaHSP16.8, TaHSP17, TaHSP17.3, and TaHSP90.1-A1) as well as TaGAAP and TaRof1 (a co-chaperone) under non-stress conditions. DNA binding analysis revealed the presence of high-affinity TaHsfA6f-binding heat shock element-like motifs in the promoters of these six genes. Promoter truncation and mutagenesis analyses identified TaHsfA6f-binding elements that were responsible for transactivation of TaHSP90.1-A1 and TaGAAP by TaHsfA6f. These data suggest that TaHsfA6f is a transcriptional activator that directly regulates TaHSP, TaGAAP, and TaRof1 genes in wheat and its gene regulatory network has a positive impact on thermotolerance. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology.

Pleiotropic Regulation of Virulence Genes in Streptococcus mutans by the Conserved Small Protein SprV.

Science.gov (United States)

Shankar, Manoharan; Hossain, Mohammad S; Biswas, Indranil

2017-04-15

Streptococcus mutans , an oral pathogen associated with dental caries, colonizes tooth surfaces as polymicrobial biofilms known as dental plaque. S. mutans expresses several virulence factors that allow the organism to tolerate environmental fluctuations and compete with other microorganisms. We recently identified a small hypothetical protein (90 amino acids) essential for the normal growth of the bacterium. Inactivation of the gene, SMU.2137, encoding this protein caused a significant growth defect and loss of various virulence-associated functions. An S. mutans strain lacking this gene was more sensitive to acid, temperature, osmotic, oxidative, and DNA damage-inducing stresses. In addition, we observed an altered protein profile and defects in biofilm formation, bacteriocin production, and natural competence development, possibly due to the fitness defect associated with SMU.2137 deletion. Transcriptome sequencing revealed that nearly 20% of the S. mutans genes were differentially expressed upon SMU.2137 deletion, thereby suggesting a pleiotropic effect. Therefore, we have renamed this hitherto uncharacterized gene as sprV ( s treptococcal p leiotropic r egulator of v irulence). The transcript levels of several relevant genes in the sprV mutant corroborated the phenotypes observed upon sprV deletion. Owing to its highly conserved nature, inactivation of the sprV ortholog in Streptococcus gordonii also resulted in poor growth and defective UV tolerance and competence development as in the case of S. mutans Our experiments suggest that SprV is functionally distinct from its homologs identified by structure and sequence homology. Nonetheless, our current work is aimed at understanding the importance of SprV in the S. mutans biology. IMPORTANCE Streptococcus mutans employs several virulence factors and stress resistance mechanisms to colonize tooth surfaces and cause dental caries. Bacterial pathogenesis is generally controlled by regulators of fitness that are

Design of power auto-regulating system's high reliability controller for 200 MW nuclear heating reactor

International Nuclear Information System (INIS)

An Zhencai; Liu Longzhi; Chen Yuan

1996-01-01

The paper mainly introduces power auto-regulating system's high reliability controller for 200 MW Nuclear Heating Reactor. The controller is implemented with excellent performance 16 bit single chip microcomputer 8097. Master controller and 10 digit samplers are blocked. Each and every block's hardware is identical. These blocks communicate each other through 8 bit BUS and operate synchronously by united clock and reset signal and are designed with three redundancies. The identity comparison principle through two-out-of three is also introduced. The test proves that designing scheme is feasible

Annotated directory of energy conservation programs

Energy Technology Data Exchange (ETDEWEB)

Claxton, J.D.; McDougall, G.H.G.; Ritchie, J.R.B. (eds.)

1980-01-01

Summaries of 34 consumer energy conservation programs in Canada and the USA are listed. Areas of focus are: (1) home heating and cooling; (2) household appliances; (3) private transportation; and (4) community involvement. Each summary contains information on the program objectives, operating details, results to date, costs and benefits, and source of funding. The key contact person is identified and background literature references are given. ((MJJ)

Crystal Structure of the HEAT Domain from the Pre-mRNA Processing Factor Symplekin

Energy Technology Data Exchange (ETDEWEB)

Kennedy, Sarah A.; Frazier, Monica L.; Steiniger, Mindy; Mast, Ann M.; Marzluff, William F.; Redinbo, Matthew R.; (UNC)

2010-09-30

The majority of eukaryotic pre-mRNAs are processed by 3'-end cleavage and polyadenylation, although in metazoa the replication-dependent histone mRNAs are processed by 3'-end cleavage but not polyadenylation. The macromolecular complex responsible for processing both canonical and histone pre-mRNAs contains the {approx} 1160-residue protein Symplekin. Secondary-structural prediction algorithms identified putative HEAT domains in the 300 N-terminal residues of all Symplekins of known sequence. The structure and dynamics of this domain were investigated to begin elucidating the role Symplekin plays in mRNA maturation. The crystal structure of the Drosophila melanogaster Symplekin HEAT domain was determined to 2.4 {angstrom} resolution with single-wavelength anomalous dispersion phasing methods. The structure exhibits five canonical HEAT repeats along with an extended 31-amino-acid loop (loop 8) between the fourth and fifth repeat that is conserved within closely related Symplekin sequences. Molecular dynamics simulations of this domain show that the presence of loop 8 dampens correlated and anticorrelated motion in the HEAT domain, therefore providing a neutral surface for potential protein-protein interactions. HEAT domains are often employed for such macromolecular contacts. The Symplekin HEAT region not only structurally aligns with several established scaffolding proteins, but also has been reported to contact proteins essential for regulating 3'-end processing. Together, these data support the conclusion that the Symplekin HEAT domain serves as a scaffold for protein-protein interactions essential to the mRNA maturation process.

Not changes in membrane fluidity but proteotoxic stress triggers heat shock protein expression in Chlamydomonas reinhardtii.

Science.gov (United States)

Rütgers, Mark; Muranaka, Ligia Segatto; Schulz-Raffelt, Miriam; Thoms, Sylvia; Schurig, Juliane; Willmund, Felix; Schroda, Michael

2017-12-01

A conserved reaction of all organisms exposed to heat stress is an increased expression of heat shock proteins (HSPs). Several studies have proposed that HSP expression in heat-stressed plant cells is triggered by an increased fluidity of the plasma membrane. Among the main lines of evidence in support of this model are as follows: (a) the degree of membrane lipid saturation was higher in cells grown at elevated temperatures and correlated with a lower amplitude of HSP expression upon a temperature upshift, (b) membrane fluidizers induce HSP expression at physiological temperatures, and (c) membrane rigidifier dimethylsulfoxide dampens heat-induced HSP expression. Here, we tested whether this holds also for Chlamydomonas reinhardtii. We show that heat-induced HSP expression in cells grown at elevated temperatures was reduced because they already contained elevated levels of cytosolic HSP70A/90A that apparently act as negative regulators of heat shock factor 1. We find that membrane rigidifier dimethylsulfoxide impaired translation under heat stress conditions and that membrane fluidizer benzyl alcohol not only induced HSP expression but also caused protein aggregation. These findings support the classical model for the cytosolic unfolded protein response, according to which HSP expression is induced by the accumulation of unfolded proteins. Hence, the membrane fluidity model should be reconsidered. © 2017 John Wiley & Sons Ltd.

A concept of passive safety pressurized water reactor system with inherent matching nature of core heat generation and heat removal

International Nuclear Information System (INIS)

Murao, Yoshio; Araya, Fumimasa; Iwamura, Takamichi; Okumura, Keisuke

1995-01-01

The reduction of manpower in operation and maintenance by simplification of the system are essential to improve the safety and the economy of future light water reactors. At the Japan Atomic Energy Research Institute (JAERI), a concept of a simplified passive safety reactor system JPSR was developed for this purpose and in the concept minimization of developing work and conservation of scale-up capability in design were considered. The inherent matching nature of core heat generation and heat removal rate is introduced by the core with high reactivity coefficient for moderator density and low reactivity coefficient for fuel temperature (Doppler effect) and once-through steam generators (SGs). This nature makes the nuclear steam supply system physically-slave for the steam and energy conversion system by controlling feed water mass flow rate. The nature can be obtained by eliminating chemical shim and adopting in-vessel control rod drive mechanism (CRDM) units and a low power density core. In order to simplify the system, a large pressurizer, canned pumps, passive residual heat removal systems with air coolers as a final heat sink and passive coolant injection system are adopted and the functions of volume and boron concentration control and seal water supply are eliminated from the chemical and volume control system (CVCS). The emergency diesel generators and auxiliary component cooling system of 'safety class' for transferring heat to sea water as a final heat sink in emergency are also eliminated. All of systems are built in the containment except for the air coolers of the passive residual heat removal system. The analysis of the system revealed that the primary coolant expansion in 100% load reduction in 60 s can be mitigated in the pressurizer without actuating the pressure relief valves and the pressure in 50% load change in 30 s does not exceed the maximum allowable pressure in accidental conditions in regardless of pressure regulation. (author)

Design heating test section HeaTiNG-02

International Nuclear Information System (INIS)

Riswan Djambiar; Sagino; Dedy Haryanto; Joko Prasetio Witoko

2013-01-01

HeaTiNG-02 is a component test loop BETA which serves as a heater in conducting experimental heat transfer processes in two-phase flow in narrow slit-shaped plate, considering this phenomenon is one of the conditions postulated accident scenarios a NPP type PWR. To produce heat for the heating component takes the AC power the source voltage can be set from 0 Volts to 220 Volts with no more than a maximum power of 25 KVA. To obtain the thermal conditions on HeaTiNG-02 heating wire dimensions need to be determined and the corresponding voltage so that it will an expected power. Determination of the dimensions of the heater wire through calculations using electricity formulations. Retrieved draft heater test BETA (UUB) HeaTiNG-02 use material super kanthal (FeCuAl) in diameter (Ø) = 2 mm and wire length 3770 mm. Voltage regulators with a maximum power of 25 kVA with a minimum voltage of 0 volts and a maximum of 220 volts. Heater is used as the base to form refractory stone trench. (author)

Cooling energy efficiency and classroom air environment of a school building operated by the heat recovery air conditioning unit

International Nuclear Information System (INIS)

Wang, Yang; Zhao, Fu-Yun; Kuckelkorn, Jens; Liu, Di; Liu, Li-Qun; Pan, Xiao-Chuan

2014-01-01

The recently-built school buildings have adopted novel heat recovery ventilator and air conditioning system. Heat recovery efficiency of the heat recovery facility and energy conservation ratio of the air conditioning unit were analytically modeled, taking the ventilation networks into account. Following that, school classroom displacement ventilation and its thermal stratification and indoor air quality indicated by the CO 2 concentration have been numerically modeled concerning the effects of delivering ventilation flow rate and supplying air temperature. Numerical results indicate that the promotion of mechanical ventilation rate can simultaneously boost the dilution of indoor air pollutants and the non-uniformity of indoor thermal and pollutant distributions. Subsequent energy performance analysis demonstrates that classroom energy demands for ventilation and cooling could be reduced with the promotion of heat recovery efficiency of the ventilation facility, and the energy conservation ratio of the air conditioning unit decreases with the increasing temperatures of supplying air. Fitting correlations of heat recovery ventilation and cooling energy conservation have been presented. - Highlights: • Low energy school buildings and classroom environment. • Heat recovery facility operating with an air conditioning unit. • Displacement ventilation influenced by the heat recovery efficiency. • Energy conservation of cooling and ventilation through heat recovery. • Enhancement of classroom environment with reduction of school building energy

Energy conservation and the residential and commercial sector

Science.gov (United States)

1975-01-01

A detailed analysis of energy conservation actions relevant to the residential and commercial sector has led to the conclusion that the potential for savings is great. The task will not be easy, however, since many of the actions require significant life style changes that are difficult to accomplish. Furthermore, many of the conservation actions cited as instant solutions to the energy crisis are those with only mid to long term potential, such as solar energy or heat pumps. Three significant conservation approaches are viable: adjusting price structure, mandating actions, and educating consumers. The first two appear to be the most feasible. But they are not without a price. Higher utility bills adversely affect the poor and the elderly on fixed incomes. Likewise, strict mandatory measures can be quite distasteful. But the effect of alternatives, such as voluntary savings accomplished through education processes, is minimal in a nation without a true conservation ethic.

Regulation of the heat shock response under anoxia in the turtle, Trachemys scripta elegans.

Science.gov (United States)

Krivoruchko, Anastasia; Storey, Kenneth B

2010-03-01

The effects of 20 h of anoxic submergence in cold water and 5 h of aerobic recovery on the heat shock response were analyzed in four organs of the anoxia-tolerant turtle Trachemys scripta elegans. Immunoblotting was used to analyze levels of active and inactive forms of the heat shock transcription factor 1 (HSF1), nuclear translocation of HSF1, and the levels of six heat shock proteins (HSPs). PCR was also used to retrieve the turtle HSF1 nucleotide sequence; its deduced amino acid sequence showed 97% identity with chicken HSF1. White skeletal muscle showed a strong fivefold increase in the amount of active HSF1 under anoxic conditions as well as an 80% increase in nuclear localization. This was accompanied by upregulation of five HSPs by 1.8- to 2.9-fold: Hsp25, Hsp40, Hsp70, Hsc70, and Hsp90, the latter two remained elevated after 5 h of aerobic recovery. Kidney and liver showed little change in active HSF1 content during anoxia and recovery, but a significant increase in the nuclear localization of HSF1 during anoxia. This supported enhanced expression of three HSPs in kidney (Hsp40, Hsc70, and Hsp90) and four in liver (Hsp40, Hsp60, Hsp70, Hsc70). Heart displayed a strong increase in active HSF1 during anoxia and recovery (6.6- to 6.8-fold higher than control) and increased nuclear localization but heart HSP levels did not rise. The data demonstrate organ-specific regulation of HSPs during anoxia exposure and aerobic recovery in T. s. elegans and suggest that the heat shock response is an important aspect of cytoprotection during facultative anaerobiosis, particularly with regard to underwater hibernation of turtles in cold water.

Balancing of solar heating options

NARCIS (Netherlands)

Veltkamp, W.B.; van Koppen, C.W.J.; Ouden, den C.

1984-01-01

In the field of energy conservation many options are presently competing. This study aims at providing more rational criteria for selection between these options.The options considered are; insulation of the walls, regeneration of the heat in the waste air, double glazing, attached sunspace at the

Danish heat atlas as a support tool for energy system models

DEFF Research Database (Denmark)

Petrovic, Stefan; Karlsson, Kenneth Bernard

2014-01-01

In the past four decades following the global oil crisis in 1973, Denmark has implemented remarkable changes in its energy sector, mainly due to the energy conservation measures on the demand side and the energy efficiency improvements on the supply side. Nowadays, the capital intensive infrastru......In the past four decades following the global oil crisis in 1973, Denmark has implemented remarkable changes in its energy sector, mainly due to the energy conservation measures on the demand side and the energy efficiency improvements on the supply side. Nowadays, the capital intensive...... infrastructure investments, such as the expansion of district heating networks and the introduction of significant heat saving measures require highly detailed decision-support tool. A Danish heat atlas provides highly detailed database with extensive information about more than 2.5 million buildings in Denmark...... society after 2050. The present paper shows how a Danish heat atlas can be used for providing inputs to energy system models, especially related to the analysis of heat saving measures within building stock and expansion of district heating networks. As a result, marginal cost curves are created...

Energy conservation and fuel substitution in Ube Kosan

Energy Technology Data Exchange (ETDEWEB)

1982-01-01

After describing various changes in the Ube Kosan of Japan, an account is given of the history of the energy changeover and conservation being promoted by this company, together with details of the results of these measures and the company structures involved. Topics mentioned include imports of coal, the changeover to coal as a heat source in the production of cement and for the company's private power generation, the establishment of a coal centre, the organization of the drive towards energy conservation, the adoption of the SAVE technique, feedstock substitution, and the state of development of new processes.

Conservation voltage regulation (CVR) applied to energy savings by voltage-adjusting equipment through AMI

Science.gov (United States)

Lan, B.-R.; Chang, C.-A.; Huang, P.-Y.; Kuo, C.-H.; Ye, Z.-J.; Shen, B.-C.; Chen, B.-K.

2017-11-01

Conservation voltage reduction (CVR) includes peak demand reduction, energy conservation, carbon emission reduction, and electricity bill reduction. This paper analyzes the energy-reduction of Siwei Feeders with applying CVR, which are situated in Penghu region and equipped with smart meters. Furthermore, the applicable voltage reduction range for the feeders will be explored. This study will also investigate how the CVR effect and energy conservation are improved with the voltage control devices integrated. The results of this study can serve as a reference for the Taiwan Power Company to promote and implement voltage reduction and energy conservation techniques. This study is expected to enhance the energy-reduction performance of the Penghu Low Carbon Island Project.

Energy conservation in mechanical industry; Maitrise de l`energie dans les industries mecaniques

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-12-31

The workshop is composed of 12 communications on the theme of energy consumption, conservation and management in industry, and more especially in metal industry: evaluation of the energy savings potential in the French industry; official energy diagnosis procedure in buildings; the French national gas utility policy for energy conservation and economical performance in industry; energy conservation with speed variators for electric motors; energy audits and energy metering for conservation objectives. Examples of energy efficient systems or energy audits in various industrial sectors (compressed air, industrial buildings, heat treatments, curing...) are also presented. The electric power quality EDF`s contract is also discussed

77 FR 74559 - Energy Conservation Program for Consumer Products: Test Procedures for Residential Water Heaters...

Science.gov (United States)

2012-12-17

... Conservation Program for Consumer Products: Test Procedures for Residential Water Heaters, Direct Heating... Energy (DOE) is amending its test procedures for residential water heaters, direct heating equipment (DHE... necessary for residential water heaters, because the existing test procedures for those products already...

76 FR 56347 - Energy Conservation Program for Consumer Products: Test Procedures for Residential Water Heaters...

Science.gov (United States)

2011-09-13

... Conservation Program for Consumer Products: Test Procedures for Residential Water Heaters, Direct Heating... proposed to amend, where appropriate, its test procedures for residential water heaters, direct heating... notes that the test procedure and metric for residential water heaters currently address and incorporate...

District heating

International Nuclear Information System (INIS)

Hansen, L.

1993-01-01

The environmental risks and uncertainties of a high-energy future are disturbing and give rise to several reservations concerning the use of fossil fuels. A number of technologies will help to reduce atmospheric pollution. In Denmark special importance is attached to the following: Energy conservation. Efficient energy conversion. Renewable energy sources. District heating, combined production of heat and power. Many agree that district heating (DH), produced by the traditional heat-only plant, and combined heat and power (CHP) have enormous potential when considering thermal efficiency and lowered environmental impacts: The basic technology of each is proven, it would be relatively simple to satisfy a substantial part of the energy demand, and their high efficiencies mean reduced pollution including greenhouse gas emissions. This is especially important in high population density areas - the obviously preferred sites for such energy generation. Compared with individual heating DH can provide a community with an operationally efficient and most often also an economically competitive heat supply. This is particularly true under the circumstances where the DH system is supplied from CHP plants. Their use results in very substantial improvements in overall efficiency. Further environmental improvements arise from the reduced air pollution obtainable in reasonably large CHP plants equipped with flue gas cleaning to remove particles, sulphur dioxide, and nitrogen acids. As a consequence of these considerations, DH plays an important role in fulfilling the space and water heating demand in many countries. This is especially the case in Denmark where this technology is utilised to a very great extent. Indeed, DH is one of the reasons why Denmark has relatively good air quality in the cities. (au)

Theoretical insight into the heat shock response (HSR) regulation in Lactobacillus casei and L. rhamnosus.

Science.gov (United States)

Rossi, Franca; Zotta, Teresa; Iacumin, Lucilla; Reale, Anna

2016-08-07

The understanding of the heat shock response (HSR) in lactobacilli from a regulatory point of view is still limited, though an increased knowledge on the regulation of this central stress response can lead to improvements in the exploitation of these health promoting microorganisms. Therefore the aim of this in silico study, that is the first to be carried out for members of the Lactobacillus genus, was predicting how HSR influences cell functions in the food associated and probiotic species Lactobacillus casei and Lactobacillus rhamnosus. To this purpose, thirteen whole genomes of these bacteria were analyzed to identify which genes involved in HSR are present. It was found that all the genomes share 25 HSR related genes, including those encoding protein repair systems, HSR repressors, HrcA and CtsR, and the positive regulators of HSR, alternative σ factors σ(32) and σ(24). Two genes encoding a σ(70)/σ(24) factor and a Lon protease, respectively, were found only in some genomes. The localization of the HSR regulators binding sites in genomes was analyzed in order to identify regulatory relationships driving HSR in these lactobacilli. It was observed that the binding site for the HrcA repressor is found upstream of the hrcA-grpE-dnaK-dnaJ and groES-groEL gene clusters, of two hsp genes, clpE, clpL and clpP, while the CtsR repressor binding site precedes the ctsR-clpC operon, clpB, clpE and clpP. Therefore the ClpE-ClpP protease complex is dually regulated by HrcA and CtsR. Consensus sequences for the promoters recognized by the HSR alternative σ factors were defined for L. casei and L. rhamnosus and were used in whole genome searches to identify the genes that are possibly regulated by these transcription factors and whose expression level is expected to increases in HSR. The results were validated by applying the same procedure of promoter consensus generation and whole genome search to an additional 11 species representative of the main Lactobacillus

A conserved WW domain-like motif regulates invariant chain-dependent cell-surface transport of the NKG2D ligand ULBP2

DEFF Research Database (Denmark)

Uhlenbrock, Franziska Katharina; van Andel, Esther; Andresen, Lars

2015-01-01

that the NKG2D ligand ULBP2 traffics over an invariant chain (Ii)-dependent pathway to the cell surface. This study set out to elucidate how Ii regulates ULBP2 cell-surface transport: We discovered conserved tryptophan (Trp) residues in the primary protein sequence of ULBP1-6 but not in the related MICA....../B. Substitution of Trp to alanine resulted in cell-surface inhibition of ULBP2 in different cancer cell lines. Moreover, the mutated ULBP2 constructs were retained and not degraded inside the cell, indicating a crucial role of this conserved Trp-motif in trafficking. Finally, overexpression of Ii increased...... surface expression of wt ULBP2 while Trp-mutants could not be expressed, proposing that this Trp-motif is required for an Ii-dependent cell-surface transport of ULBP2. Aberrant soluble ULBP2 is immunosuppressive. Thus, targeting a distinct protein module on the ULBP2 sequence could counteract...

Genome-Scale Co-Expression Network Comparison across Escherichia coli and Salmonella enterica Serovar Typhimurium Reveals Significant Conservation at the Regulon Level of Local Regulators Despite Their Dissimilar Lifestyles

Science.gov (United States)

Zarrineh, Peyman; Sánchez-Rodríguez, Aminael; Hosseinkhan, Nazanin; Narimani, Zahra; Marchal, Kathleen; Masoudi-Nejad, Ali

2014-01-01

Availability of genome-wide gene expression datasets provides the opportunity to study gene expression across different organisms under a plethora of experimental conditions. In our previous work, we developed an algorithm called COMODO (COnserved MODules across Organisms) that identifies conserved expression modules between two species. In the present study, we expanded COMODO to detect the co-expression conservation across three organisms by adapting the statistics behind it. We applied COMODO to study expression conservation/divergence between Escherichia coli, Salmonella enterica, and Bacillus subtilis. We observed that some parts of the regulatory interaction networks were conserved between E. coli and S. enterica especially in the regulon of local regulators. However, such conservation was not observed between the regulatory interaction networks of B. subtilis and the two other species. We found co-expression conservation on a number of genes involved in quorum sensing, but almost no conservation for genes involved in pathogenicity across E. coli and S. enterica which could partially explain their different lifestyles. We concluded that despite their different lifestyles, no significant rewiring have occurred at the level of local regulons involved for instance, and notable conservation can be detected in signaling pathways and stress sensing in the phylogenetically close species S. enterica and E. coli. Moreover, conservation of local regulons seems to depend on the evolutionary time of divergence across species disappearing at larger distances as shown by the comparison with B. subtilis. Global regulons follow a different trend and show major rewiring even at the limited evolutionary distance that separates E. coli and S. enterica. PMID:25101984

Constructing regulation and regulating for energy efficient construction

Energy Technology Data Exchange (ETDEWEB)

Shove, Elizabeth [Lancaster University (United Kingdom). Centre for the Study of Environmental Change

1998-07-01

This project considers the process of formulating energy-related building regulation in the light of the revisions to Part L (Conservation of Fuel and Power) of the Building Regulations for England and Wales. Details are given of the main objectives of the research, namely, the examination of the roles of the UK government, local government and pressure groups in shaping energy efficiency standards, the impacts of environmental regulations, the limits of energy-related regulation, environmental regulation of the building sector, and the features of energy related building control. This control is compared with current practice in other European countries. The methodology of the project involving the review of governmental documents and interviews is described. (UK)

Novel views on the extraction of energy from wind. Heat generation and terrain concentration

Energy Technology Data Exchange (ETDEWEB)

Corten, G.P. [ECN Wind, Petten (Netherlands)

2001-09-01

First it will be shown that an actuator disk operating in wind turbine mode extracts more energy from the fluid than can be transferred into useful energy. At the Lanchester-Betz limit the decrease of the kinetic energy in the wind is converted by 2/3 into useful power and by 1/3 into heat. Behind the wind turbine the outer flow and the flow that has passed the actuator disk will mix. In this process momentum is conserved but part of the kinetic energy will dissipate in heat via viscous shear. Second we will explain that the classic site calibration in complex terrain has no physical basis. The concentration will depend on the wind direction and this implies that a turbine (pitch- or stall regulated) is expected to have multiple power levels depending on the wind direction under such circumstances. These multiple power levels are expected in particular below rated wind speed. This analysis is put forward in appendix A. 10 refs.

48 CFR 536.570-11 - Heat.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Heat. 536.570-11 Section... OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 536.570-11 Heat. Insert the clause at 552.236-80, Heat, in solicitations and contracts if construction, dismantling...

Prinsip Umum Penatalaksanaan Cedera Olahraga Heat Stroke

OpenAIRE

Ade Tobing, Saharun Iso

2016-01-01

Exercises that are conducted in an extreme heat environment can cause heat injury. Heatinjury is associated with disturbance to temperature regulation and cardiovascular systems. Heatstroke is the most severe type of heat injury. Heat stroke is associated with high morbidity andmortality numbers, particularly if therapy treatment is delayed. In general, heat stroke is caused bytwo things, namely increase in heat production and decrease in heat loss.Heat stroke signs include: (1) rectal temper...

The roles of KCa, KATP, and KV channels in regulating cutaneous vasodilation and sweating during exercise in the heat.

Science.gov (United States)

Louie, Jeffrey C; Fujii, Naoto; Meade, Robert D; McNeely, Brendan D; Kenny, Glen P

2017-05-01

We recently showed the varying roles of Ca 2+ -activated (K Ca ), ATP-sensitive (K ATP ), and voltage-gated (K V ) K + channels in regulating cholinergic cutaneous vasodilation and sweating in normothermic conditions. However, it is unclear whether the respective contributions of these K + channels remain intact during dynamic exercise in the heat. Eleven young (23 ± 4 yr) men completed a 30-min exercise bout at a fixed rate of metabolic heat production (400 W) followed by a 40-min recovery period in the heat (35°C, 20% relative humidity). Cutaneous vascular conductance (CVC) and local sweat rate were assessed at four forearm skin sites perfused via intradermal microdialysis with: 1 ) lactated Ringer solution (control); 2 ) 50 mM tetraethylammonium (nonspecific K Ca channel blocker); 3 ) 5 mM glybenclamide (selective K ATP channel blocker); or 4 ) 10 mM 4-aminopyridine (nonspecific K V channel blocker). Responses were compared at baseline and at 10-min intervals during and following exercise. K Ca channel inhibition resulted in greater CVC versus control at end exercise ( P = 0.04) and 10 and 20 min into recovery (both P exercise (all P ≤ 0.04), and 10 min into recovery ( P = 0.02). No differences in CVC were observed with K V channel inhibition during baseline ( P = 0.15), exercise (all P ≥ 0.06), or recovery (all P ≥ 0.14). With the exception of K V channel inhibition augmenting sweating during baseline ( P = 0.04), responses were similar to control with all K + channel blockers during each time period (all P ≥ 0.07). We demonstrated that K Ca and K ATP channels contribute to the regulation of cutaneous vasodilation during rest and/or exercise and recovery in the heat. Copyright © 2017 the American Physiological Society.

Counter of Energy Conservation and Emission Reduction for the Public in China

Energy Technology Data Exchange (ETDEWEB)

Wujun Wen; Xiaowen Liu; Geng Xu (Research Center for Sustainable Development of Shandong Province, Shandong Normal Univ., Jinan Shandong 250014 (China)). e-mail: wenwj@sdnu.edu.cn

2009-05-15

The Ministry of Science and Technology of China organized experts to develop the Internet-based software Counter of Energy Conservation and Emission Reduction to directly measure energy conservation and emission reduction potentials in people's daily lives. Research and testing of the software have been completed, and the software is available to the public on the Internet. The Counter of Energy Conservation and Emission Reduction software is being promoted with the aim of stimulating the public's enthusiasm for energy conservation and emission reduction. The software is of great significance in energy conservation and emission reduction education oriented to elementary and middle school students and community residents, thus changing the lagged public participation of Chinese citizens in energy conservation and emission reduction. The counter can calculate people's energy conservation and emission reduction potential in six aspects of daily life. The user can know his or her value of energy conservation and emission reduction in each aspect by clicking the options in keeping with his or her true daily routines. The user can also know the amounts of energy conservation and emission reduction as well as the potential energy conservation and emission reduction of the whole nation by clicking the Effect Calculation Button. Family life areas mainly include the methods and habits of water use, the use of energy conservation cookers, methods of saving paper, the use of environmental protection products, the habit of home appliance use, and the methods of washing clothing, especially the use of the washing machine with the function of energy conservation. Housing includes the building materials, the heating and cooling systems, the temperature control measures, and the lighting, etc. Heating and cooling times for the house by air conditioner should be reduced. Architects can do a great deal by using energy-efficient building materials and designing houses

Analysis of a waste-heat boiler by CFD simulation

Energy Technology Data Exchange (ETDEWEB)

Yang, Yongziang; Jokilaakso, A. [Helsinki Univ. of Technology, Otaniemi (Finland)

1996-12-31

Waste-heat boilers play important roles in the continuous operation of a smelter and in the conservation of energy. However, the fluid flow and heat transfer behaviour has not been well studied, concerning the boiler performance and design. This presentation describes simulated gas flow and heat transfer of a waste-heat boiler in the Outokumpu copper flash smelting process. The governing transport equations for the conservation of mass, momentum and enthalpy were solved with a commercial CFD-code PHOENICS. The standard k-{epsilon} turbulence model and a composite-flux radiation model were used in the computations. The computational results show that the flow is strongly recirculating and distinctly three-dimensional in most part of the boiler, particularly in the radiation section. The predicted flow pattern and temperature distribution were in a good agreement with laboratory models and industrial measurements. The results provide detailed information of flow pattern, the temperature distribution and gas cooling efficiency. The CFD proved to be a useful tool in analysing the boiler operation. (author)

Analysis of a waste-heat boiler by CFD simulation

Energy Technology Data Exchange (ETDEWEB)

Yang, Yongziang; Jokilaakso, A [Helsinki Univ. of Technology, Otaniemi (Finland)

1997-12-31

Waste-heat boilers play important roles in the continuous operation of a smelter and in the conservation of energy. However, the fluid flow and heat transfer behaviour has not been well studied, concerning the boiler performance and design. This presentation describes simulated gas flow and heat transfer of a waste-heat boiler in the Outokumpu copper flash smelting process. The governing transport equations for the conservation of mass, momentum and enthalpy were solved with a commercial CFD-code PHOENICS. The standard k-{epsilon} turbulence model and a composite-flux radiation model were used in the computations. The computational results show that the flow is strongly recirculating and distinctly three-dimensional in most part of the boiler, particularly in the radiation section. The predicted flow pattern and temperature distribution were in a good agreement with laboratory models and industrial measurements. The results provide detailed information of flow pattern, the temperature distribution and gas cooling efficiency. The CFD proved to be a useful tool in analysing the boiler operation. (author)

Identification of a conserved set of upregulated genes in mouse skeletal muscle hypertrophy and regrowth.

Science.gov (United States)

Chaillou, Thomas; Jackson, Janna R; England, Jonathan H; Kirby, Tyler J; Richards-White, Jena; Esser, Karyn A; Dupont-Versteegden, Esther E; McCarthy, John J

2015-01-01

The purpose of this study was to compare the gene expression profile of mouse skeletal muscle undergoing two forms of growth (hypertrophy and regrowth) with the goal of identifying a conserved set of differentially expressed genes. Expression profiling by microarray was performed on the plantaris muscle subjected to 1, 3, 5, 7, 10, and 14 days of hypertrophy or regrowth following 2 wk of hind-limb suspension. We identified 97 differentially expressed genes (≥2-fold increase or ≥50% decrease compared with control muscle) that were conserved during the two forms of muscle growth. The vast majority (∼90%) of the differentially expressed genes was upregulated and occurred at a single time point (64 out of 86 genes), which most often was on the first day of the time course. Microarray analysis from the conserved upregulated genes showed a set of genes related to contractile apparatus and stress response at day 1, including three genes involved in mechanotransduction and four genes encoding heat shock proteins. Our analysis further identified three cell cycle-related genes at day and several genes associated with extracellular matrix (ECM) at both days 3 and 10. In conclusion, we have identified a core set of genes commonly upregulated in two forms of muscle growth that could play a role in the maintenance of sarcomere stability, ECM remodeling, cell proliferation, fast-to-slow fiber type transition, and the regulation of skeletal muscle growth. These findings suggest conserved regulatory mechanisms involved in the adaptation of skeletal muscle to increased mechanical loading. Copyright © 2015 the American Physiological Society.

Simulation and energy analysis of distributed electric heating system

Science.gov (United States)

Yu, Bo; Han, Shenchao; Yang, Yanchun; Liu, Mingyuan

2018-02-01

Distributed electric heating system assistssolar heating systemby using air-source heat pump. Air-source heat pump as auxiliary heat sourcecan make up the defects of the conventional solar thermal system can provide a 24 - hour high - efficiency work. It has certain practical value and practical significance to reduce emissions and promote building energy efficiency. Using Polysun software the system is simulated and compared with ordinary electric boiler heating system. The simulation results show that upon energy request, 5844.5kW energy is saved and 3135kg carbon - dioxide emissions are reduced and5844.5 kWhfuel and energy consumption is decreased with distributed electric heating system. Theeffect of conserving energy and reducing emissions using distributed electric heating systemis very obvious.

Regulation and Measurement of the Heat Generated by Automatic Tooth Preparation in a Confined Space.

Science.gov (United States)

Yuan, Fusong; Zheng, Jianqiao; Sun, Yuchun; Wang, Yong; Lyu, Peijun

2017-06-01

The aim of this study was to assess and regulate heat generation in the dental pulp cavity and circumambient temperature around a tooth during laser ablation with a femtosecond laser in a confined space. The automatic tooth preparing technique is one of the traditional oral clinical technology innovations. In this technique, a robot controlled an ultrashort pulse laser to automatically complete the three-dimensional teeth preparing in a confined space. The temperature control is the main measure for protecting the tooth nerve. Ten tooth specimens were irradiated with a femtosecond laser controlled by a robot in a confined space to generate 10 teeth preparation. During the process, four thermocouple sensors were used to record the pulp cavity and circumambient environment temperatures with or without air cooling. A statistical analysis of the temperatures was performed between the conditions with and without air cooling (p heat generated in the pulp cavity was lower than the threshold for dental pulp damage. These results indicate that femtosecond laser ablation with air cooling might be an appropriate method for automatic tooth preparing.

The social implications of using drones for biodiversity conservation.

Science.gov (United States)

Sandbrook, Chris

2015-11-01

Unmanned aerial vehicles, or 'drones', appear to offer a flexible, accurate and affordable solution to some of the technical challenges of nature conservation monitoring and law enforcement. However, little attention has been given to their possible social impacts. In this paper, I review the possible social impacts of using drones for conservation, including on safety, privacy, psychological wellbeing, data security and the wider understanding of conservation problems. I argue that negative social impacts are probable under some circumstances and should be of concern for conservation for two reasons: (1) because conservation should follow good ethical practice; and (2) because negative social impacts could undermine conservation effectiveness in the long term. The paper concludes with a call for empirical research to establish whether the identified social risks of drones occur in reality and how they could be mitigated, and for self-regulation of drone use by the conservation sector to ensure good ethical practice and minimise the risk of unintended consequences.

Redox Activation of the Universally Conserved ATPase YchF by Thioredoxin 1.

Science.gov (United States)

Hannemann, Liya; Suppanz, Ida; Ba, Qiaorui; MacInnes, Katherine; Drepper, Friedel; Warscheid, Bettina; Koch, Hans-Georg

2016-01-20

YchF/Ola1 are unconventional members of the universally conserved GTPase family because they preferentially hydrolyze ATP rather than GTP. These ATPases have been associated with various cellular processes and pathologies, including DNA repair, tumorigenesis, and apoptosis. In particular, a possible role in regulating the oxidative stress response has been suggested for both bacterial and human YchF/Ola1. In this study, we analyzed how YchF responds to oxidative stress and how it potentially regulates the antioxidant response. Our data identify a redox-regulated monomer-dimer equilibrium of YchF as a key event in the functional cycle of YchF. Upon oxidative stress, the oxidation of a conserved and surface-exposed cysteine residue promotes YchF dimerization, which is accompanied by inhibition of the ATPase activity. No dimers were observed in a YchF mutant lacking this cysteine. In vitro, the YchF dimer is dissociated by thioredoxin 1 (TrxA) and this stimulates the ATPase activity. The physiological significance of the YchF-thioredoxin 1 interaction was demonstrated by in vivo cross-linking, which validated this interaction in living cells. This approach also revealed that both the ATPase domain and the helical domain of YchF are in contact with TrxA. YchF/Ola1 are the first redox-regulated members of the universally conserved GTPase family and are inactivated by oxidation of a conserved cysteine residue within the nucleotide-binding motif. Our data provide novel insights into the regulation of the so far ill-defined YchF/Ola1 family of proteins and stipulate their role as negative regulators of the oxidative stress response.

BPA's Eighth Annual Energy Conservation Management Conference : Proceedings.

Energy Technology Data Exchange (ETDEWEB)

Energy Conservation Management Conference (8th : 1981); United States. Bonneville Power Administration.

1981-01-01

The five-year energy conservation program at Bonneville Power Administration (BPA) is described at the conference. An overview of the program is presented. Topics covered in panel discussions include: how utilities can work effectively with weatherization contractors, homebuilders, energy auditors, and weatherization material suppliers; mechanisms for implementing conservation programs in the commercial sector; experiences gained in existing residential weatherization programs; and streamlining relationships between consumers, utilities, and BPA in providing services and getting feedback. The planning, programming, technical assistance, and engineering thrusts of BPA's conservation programs are discussed. Indoor air quality, renewable energy, and the regulator's role in relationships to energy conservation are discussed. Passive solar programs, DOE initiatives in solar and conservation for buildings, conservation potential in the commercial and industrial sectors, and current conservation research and development are also discussed. (MCW)

Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated

Directory of Open Access Journals (Sweden)

Down Thomas A

2010-09-01

Full Text Available Abstract Background DNA methylation can regulate gene expression by modulating the interaction between DNA and proteins or protein complexes. Conserved consensus motifs exist across the human genome ("predicted transcription factor binding sites": "predicted TFBS" but the large majority of these are proven by chromatin immunoprecipitation and high throughput sequencing (ChIP-seq not to be biological transcription factor binding sites ("empirical TFBS". We hypothesize that DNA methylation at conserved consensus motifs prevents promiscuous or disorderly transcription factor binding. Results Using genome-wide methylation maps of the human heart and sperm, we found that all conserved consensus motifs as well as the subset of those that reside outside CpG islands have an aggregate profile of hyper-methylation. In contrast, empirical TFBS with conserved consensus motifs have a profile of hypo-methylation. 40% of empirical TFBS with conserved consensus motifs resided in CpG islands whereas only 7% of all conserved consensus motifs were in CpG islands. Finally we further identified a minority subset of TF whose profiles are either hypo-methylated or neutral at their respective conserved consensus motifs implicating that these TF may be responsible for establishing or maintaining an un-methylated DNA state, or whose binding is not regulated by DNA methylation. Conclusions Our analysis supports the hypothesis that at least for a subset of TF, empirical binding to conserved consensus motifs genome-wide may be controlled by DNA methylation.

Sequence conservation and combinatorial complexity of Drosophila neural precursor cell enhancers

Directory of Open Access Journals (Sweden)

Kuzin Alexander

2008-08-01

Full Text Available Abstract Background The presence of highly conserved sequences within cis-regulatory regions can serve as a valuable starting point for elucidating the basis of enhancer function. This study focuses on regulation of gene expression during the early events of Drosophila neural development. We describe the use of EvoPrinter and cis-Decoder, a suite of interrelated phylogenetic footprinting and alignment programs, to characterize highly conserved sequences that are shared among co-regulating enhancers. Results Analysis of in vivo characterized enhancers that drive neural precursor gene expression has revealed that they contain clusters of highly conserved sequence blocks (CSBs made up of shorter shared sequence elements which are present in different combinations and orientations within the different co-regulating enhancers; these elements contain either known consensus transcription factor binding sites or consist of novel sequences that have not been functionally characterized. The CSBs of co-regulated enhancers share a large number of sequence elements, suggesting that a diverse repertoire of transcription factors may interact in a highly combinatorial fashion to coordinately regulate gene expression. We have used information gained from our comparative analysis to discover an enhancer that directs expression of the nervy gene in neural precursor cells of the CNS and PNS. Conclusion The combined use EvoPrinter and cis-Decoder has yielded important insights into the combinatorial appearance of fundamental sequence elements required for neural enhancer function. Each of the 30 enhancers examined conformed to a pattern of highly conserved blocks of sequences containing shared constituent elements. These data establish a basis for further analysis and understanding of neural enhancer function.

Man-machine interface design of real-time hardware-in-loop simulation system for power regulation of nuclear heating reactor

International Nuclear Information System (INIS)

Ni Xiaoli; Huang Xiaojin; Dong Zhe

2009-01-01

It is necessary to set up real-time hardware-in-loop simulation system for power regulation of nuclear heating reactor (NHR) because it is used in the load following instance such as seawater desalination and energy source. As the experiment data are so large that it is hard to be real-time all in one computer and to save and show the data.With the distributed configuration, the system was set up having a legible and intuitionist man-machine interface, speeding the model calculation computer and meeting the requirements of power regulation of NHR. Screen clear and concise, easy command input and results output make the system easier to verify. (authors)

Heat shock factors HsfB1 and HsfB2b are involved in the regulation of Pdf1.2 expression and pathogen resistance in Arabidopsis.

Science.gov (United States)

Kumar, Mukesh; Busch, Wolfgang; Birke, Hannah; Kemmerling, Birgit; Nürnberger, Thorsten; Schöffl, Friedrich

2009-01-01

In order to assess the functional roles of heat stress-induced class B-heat shock factors in Arabidopsis, we investigated T-DNA knockout mutants of AtHsfB1 and AtHsfB2b. Micorarray analysis of double knockout hsfB1/hsfB2b plants revealed as strong an up-regulation of the basal mRNA-levels of the defensin genes Pdf1.2a/b in mutant plants. The Pdf expression was further enhanced by jasmonic acid treatment or infection with the necrotrophic fungus Alternaria brassicicola. The single mutant hsfB2b and the double mutant hsfB1/B2b were significantly improved in disease resistance after A. brassicicola infection. There was no indication for a direct interaction of Hsf with the promoter of Pdf1.2, which is devoid of perfect HSE consensus Hsf-binding sequences. However, changes in the formation of late HsfA2-dependent HSE binding were detected in hsfB1/B2b plants. This suggests that HsfB1/B2b may interact with class A-Hsf in regulating the shut-off of the heat shock response. The identification of Pdf genes as targets of Hsf-dependent negative regulation is the first evidence for an interconnection of Hsf in the regulation of biotic and abiotic responses.

Verification of calculational models of heat exchange crisis and overcrisis heat transfer, used in the KORSAR code

International Nuclear Information System (INIS)

Bezrukov, Yu.A.; Shchekoldin, V.I.

2002-01-01

On the basis of the Gidropress OKB (Special Design Bureau) experimental data bank one verified the KORSAR code design models and correlations as to heat exchange crisis and overcrisis heat transfer as applied to the WWER reactor normal and emergency conditions. The VI.006.000 version of KORSAR code base calculations is shown to describe adequately the conducted experiments and to deviate insignificantly towards the conservative approach. So it may be considered as one of the codes ensuring more precise estimation [ru

Fiscal 1999 feasibility study on energy conservation at Novo-oil refinery in Ufa City

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-31

An energy conservation plan was examined for Novo oil refinery of Bashneftechim Company in Ufa City, Bashkortstan, Russia for the purpose of making the plan tied to the COP3 joint implementation. The objective units in the study include an atmospheric and vacuum distillation unit with throughput of 7.8 million tons/year, a visbreaker and a vacuum gas oil hydrodesulfurization unit (for feedstock of FCC in Lenin Refinery), and a catalytic cracking unit, for example. Energy conservation measures are improvement and revamping of heating furnace to control excess air ratio in furnace, installation of air pre-heater or heat recovery boiler to recover heat from exhaust gas of heating furnace, additional installation of heat exchangers to recover heat from product oils, and efficiency improvement of overall operation by modernization of instrumentation and controlling equipment. The policy is not complete rebuilding of the facilities but utilizing the existing facilities by improving energy efficiency as far as possible. The study shows that investment for energy saving will be recovered within 3-6 years in many cases while total investment is estimated to be 1.5-3.0 billion yen. Total reduction of fuel consumption will be 500-800 million yen. Yearly reduction of CO2 emission will amount to 0.29 million tons (23%). (NEDO)

News from heat-pump research - Large-scale heat pumps, components, heat pumps and solar heating; News aus der Waermepumpen-Forschung - Gross-Waermepumpen, Komponenten, Waermepumpe und Solar

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-06-15

These proceedings summarise the presentations made at the 16{sup th} annual meeting held by the Swiss Federal Office of Energy's Heat Pump Research Program in Burgdorf, Switzerland. The proceedings include contributions on large-scale heat pumps, components and the activities of the heat pump promotion society. A summary of targets and trends in energy research in general is presented and an overview of the heat pump market in 2009 and future perspectives is given. International work within the framework of the International Energy Agency's heat pump group is reviewed, including solar - heat pump combinations. Field-monitoring and the analysis of large-scale heat pumps are discussed and the importance of the use of correct concepts in such installations is stressed. Large-scale heat pumps with carbon dioxide as working fluid are looked at, as are output-regulated air/water heat pumps. Efficient system solutions with heat pumps used both to heat and to cool are discussed. Deep geothermal probes and the potential offered by geothermal probes using carbon dioxide as a working fluid are discussed. The proceedings are rounded off with a list of useful addresses.

29 CFR 1919.36 - Heat treatment.

Science.gov (United States)

2010-07-01

... 29 Labor 7 2010-07-01 2010-07-01 false Heat treatment. 1919.36 Section 1919.36 Labor Regulations...) GEAR CERTIFICATION Certification of Vessels: Tests and Proof Loads; Heat Treatment; Competent Persons § 1919.36 Heat treatment. (a) The annealing of wrought iron gear required by this part shall be...

48 CFR 552.236-80 - Heat.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Heat. 552.236-80 Section... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 552.236-80 Heat. As prescribed in 536.570-11, insert the following clause: Heat (APR 1984) Unless otherwise specified or unless already...

The Heating Curve Adjustment Method

NARCIS (Netherlands)

Kornaat, W.; Peitsman, H.C.

1995-01-01

In apartment buildings with a collective heating system usually a weather compensator is used for controlling the heat delivery to the various apartments. With this weather compensator the supply water temperature to the apartments is regulated depending on the outside air temperature. With

Direct numerical simulations of fluid flow, heat transfer and phase changes

Science.gov (United States)

Juric, D.; Tryggvason, G.; Han, J.

1997-01-01

Direct numerical simulations of fluid flow, heat transfer, and phase changes are presented. The simulations are made possible by a recently developed finite difference/front tracking method based on the one-field formulation of the governing equations where a single set of conservation equations is written for all the phases involved. The conservation equations are solved on a fixed rectangular grid, but the phase boundaries are kept sharp by tracking them explicitly by a moving grid of lower dimension. The method is discussed and applications to boiling heat transfer and the solidification of drops colliding with a wall are shown.

Energy conservation in French industry and at Rhone-Poulenc

Energy Technology Data Exchange (ETDEWEB)

Mongon, A.

1979-07-01

Thirteen examples are given to illustrate France's energy conservation program. The examples show the most efficient way of energy sources management, the application of the process optimization's method, and the use of control equipment for process and heating. The details on how energy is used rationally at Rhone-Poulenc are presented.

29 CFR 1919.80 - Heat treatment.

Science.gov (United States)

2010-07-01

... 29 Labor 7 2010-07-01 2010-07-01 false Heat treatment. 1919.80 Section 1919.80 Labor Regulations...) GEAR CERTIFICATION Certification of Shore-Based Material Handling Devices § 1919.80 Heat treatment. (a) Wherever heat treatment of any loose gear is recommended by the manufacturer, it shall be carried out in...

Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation of hERG1 channels and of the VEGF-A pathway

Directory of Open Access Journals (Sweden)

La Torre Agostino

2010-09-01

Full Text Available Abstract Background Treatment strategies for Retinoblastoma (RB, the most common primary intraocular tumor in children, have evolved over the past few decades and chemoreduction is currently the most popular treatment strategy. Despite success, systemic chemotherapeutic treatment has relevant toxicity, especially in the pediatric population. Antiangiogenic therapy has thus been proposed as a valuable alternative for pediatric malignancies, in particolar RB. Indeed, it has been shown that vessel density correlates with both local invasive growth and presence of metastases in RB, suggesting that angiogenesis could play a pivotal role for both local and systemic invasive growth in RB. We present here two cases of sporadic, bilateral RB that did not benefit from the conservative treatment and we provide evidence that the VEGF-A pathway is significantly up-regulated in both RB cases along with an over expression of hERG1 K+ channels. Case presentation Two patients showed a sporadic, bilateral RB, classified at Stage II of the Reese-Elsworth Classification. Neither of them got benefits from conservative treatment, and the two eyes were enucleated. In samples from both RB cases we studied the VEGF-A pathway: VEGF-A showed high levels in the vitreous, the vegf-a, flt-1, kdr, and hif1-α transcripts were over-expressed. Moreover, both the transcripts and proteins of the hERG1 K+ channels turned out to be up-regulated in the two RB cases compared to the non cancerous retinal tissue. Conclusions We provide evidence that the VEGF-A pathway is up-regulated in two particular aggressive cases of bilateral RB, which did not experience any benefit from conservative treatment, showing the overexpression of the vegf-a, flt-1, kdr and hif1-α transcripts and the high secretion of VEGF-A. Moreover we also show for the first time that the herg1 gene transcripts and protein are over expressed in RB, as occurs in several aggressive tumors. These results further stress

Heat shock protein 70 negatively regulates the heat-shock-induced suppression of the IκB/NF-κB cascade by facilitating IκB kinase renaturation and blocking its further denaturation

International Nuclear Information System (INIS)

Lee, Kyoung-Hee; Lee, Choon-Taek; Kim, Young Whan; Han, Sung Koo; Shim, Young-Soo; Yoo, Chul-Gyu

2005-01-01

Heat shock (HS) treatment has been previously shown to suppress the IκB/nuclear factor-κB (NF-κB) cascade by denaturing, and thus inactivating IκB kinase (IKK). HS is characterized by the induction of a group of heat shock proteins (HSPs). However, their role in the HS-induced suppression of the IκB/NF-κB cascade is unclear. Adenovirus-mediated HSP70 overexpression was found not to suppress the TNF-α-induced activation of the IκB/NF-κB pathway, thus suggesting that HSP70 is unlikely to suppress this pathway. When TNF-α-induced activation of the IκB/NF-κB pathway was regained 24 h after HS, HSP70 was found to be highly up-regulated. Moreover, blocking HSP70 induction delayed TNF-α-induced IκBα degradation and the resolubilization of IKK. In addition, HSP70 associated physically with IKK, suggesting that HSP70 is involved in the recovery process via molecular chaperone effect. Adenovirus-mediated HSP70 overexpression prior to HS blocked the IκBα stabilizing effect of HS by suppressing IKK insolubilization. Moreover, the up-regulation of endogenous HSP70 by preheating, suppressed this subsequent HS-induced IKK insolubilization, and this effect was abrogated by blocking HSP70 induction. These findings indicate that HSP70 accumulates during HS and negatively regulates the HS-induced suppression of the IκB/NF-κB cascade by facilitating the renaturation of IKK and blocking its further denaturation

The Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9.

Directory of Open Access Journals (Sweden)

Ignacio Perez de la Cruz

2014-02-01

Full Text Available Loss-of-function mutations in the Caenorhabditis elegans gene sup-18 suppress the defects in muscle contraction conferred by a gain-of-function mutation in SUP-10, a presumptive regulatory subunit of the SUP-9 two-pore domain K(+ channel associated with muscle membranes. We cloned sup-18 and found that it encodes the C. elegans ortholog of mammalian iodotyrosine deiodinase (IYD, an NADH oxidase/flavin reductase that functions in iodine recycling and is important for the biosynthesis of thyroid hormones that regulate metabolism. The FMN-binding site of mammalian IYD is conserved in SUP-18, which appears to require catalytic activity to function. Genetic analyses suggest that SUP-10 can function with SUP-18 to activate SUP-9 through a pathway that is independent of the presumptive SUP-9 regulatory subunit UNC-93. We identified a novel evolutionarily conserved serine-cysteine-rich region in the C-terminal cytoplasmic domain of SUP-9 required for its specific activation by SUP-10 and SUP-18 but not by UNC-93. Since two-pore domain K(+ channels regulate the resting membrane potentials of numerous cell types, we suggest that the SUP-18 IYD regulates the activity of the SUP-9 channel using NADH as a coenzyme and thus couples the metabolic state of muscle cells to muscle membrane excitability.

Energy conservation through heat recovery steam generators at Engro Chemical Pakistan Ltd

International Nuclear Information System (INIS)

Qadir, A.; Akbar, K.N.

2002-01-01

With the deregulation of the nitrogenous fertilizer industry in Pakistan in 1986, the scenario changed for major energy conservation projects. In addition the government also started escalating the prices of natural gas. At this point they reactivated their major energy conservations projects. The plant was designed prior to the energy crisis period at the point when energy consumption was not a very major consideration. As a result, many of the energy conserving features built into subsequent plants were not included. On the gas turbine side, several changes were required in order to allow that the installation of the HRSG's. The gas turbine had to be upgraded to allow air flow due to the increased back pressure following installation of the HRSG's. Also with the uprate, the gas turbine control system had to be upgraded. The off take ducks for the HRSGs also required a design modification on the gas turbine exhaust to allow for a flanged connection, and the silencers in the exhaust duct had to be removed. The savings of natural gas was as per projections. Presently, with auxiliary firing, the HRSG's are producing 140,000 pph of steam. Their site total gas consumption has reduced by 10.6% or approximately 4 to 4.4 million CFD. In addition, the HRGS's have also provided significant ease of operation and flexibility. Of the three offsite boilers, two have been shut down and only one is operational. (A.B.)

Training program for energy conservation in new building construction. Volume III. Energy conservation technology for plan examiners and code administrators. Energy Conservation Technology Series 200

Energy Technology Data Exchange (ETDEWEB)

None

1977-12-01

Under the sponsorship of the United States Department of Energy, a Model Code for Energy Conservation in New Building Construction has been developed by those national organizations primarily concerned with the development and promulgation of model codes. The technical provisions are based on ASHRAE Standard 90-75 and are intended for use by state and local officials. The subject of regulation of new building construction to assure energy conservation is recognized as one in which code officials have not had previous exposure. It was also determined that application of the model code would be made at varying levels by officials with both a specific requirement for knowledge and a differing degree of prior training in the state-of-the-art. Therefore, a training program and instructional materials were developed for code officials to assist them in the implementation and enforcement of energy efficient standards and codes. The training program for Energy Conservation Tehnology for Plan Examiners and Code Administrators (ECT Series 200) is presented.

18 CFR 410.1 - Basin regulations-Water Code and Administrative Manual-Part III Water Quality Regulations.

Science.gov (United States)

2010-04-01

... Code and Administrative Manual-Part III Water Quality Regulations. 410.1 Section 410.1 Conservation of... CODE AND ADMINISTRATIVE MANUAL-PART III WATER QUALITY REGULATIONS § 410.1 Basin regulations—Water Code and Administrative Manual—Part III Water Quality Regulations. (a) The Water Code of the Delaware River...

Understanding the lessons and limitations of conservation and development.

Science.gov (United States)

Oldekop, Johan A; Bebbington, Anthony J; Brockington, Dan; Preziosi, Richard F

2010-04-01

The lack of concrete instances in which conservation and development have been successfully merged has strengthened arguments for strict exclusionist conservation policies. Research has focused more on social cooperation and conflict of different management regimes and less on how these factors actually affect the natural environments they seek to conserve. Consequently, it is still unknown which strategies yield better conservation outcomes? We conducted a meta-analysis of 116 published case studies on common resource management regimes from Africa, south and central America, and southern and Southeast Asia. Using ranked sociodemographic, political, and ecological data, we analyzed the effect of land tenure, population size, social heterogeneity, as well as internally devised resource-management rules and regulations (institutions) on conservation outcome. Although land tenure, population size, and social heterogeneity did not significantly affect conservation outcome, institutions were positively associated with better conservation outcomes. There was also a significant interaction effect between population size and institutions, which implies complex relationships between population size and conservation outcome. Our results suggest that communities managing a common resource can play a significant role in conservation and that institutions lead to management regimes with lower environmental impacts.

Flotillin-1 is an evolutionary-conserved memory-related protein up-regulated in implicit and explicit learning paradigms.

Science.gov (United States)

Monje, Francisco J; Divisch, Isabella; Demit, Marvie; Lubec, Gert; Pollak, Daniela D

2013-06-01

Studies of synaptic plasticity using the marine mollusk Aplysia californica as model system have been successfully used to identify proteins involved in learning and memory. The importance of molecular elements regulated by the learning- related neurotransmitter serotonin in Aplysia can then be explored in rodent models and finally tested for their relevance for human physiology and pathology. Herein, 2-DE gel-based electrophoresis has been used to investigate protein level changes after treatment with serotonin in Aplysia abdominal ganglia. Twenty-one proteins have been found to be regulated by serotonin, and protein level changes of actin depolymerizing factor (ADF), deleted in azoospermia associated protein (DAZAP-1), and Flotillin-1 have been verified by Western blotting. Flotillin-1, a member of the flotillin/reggie family of scaffolding proteins, has been previously found to be involved in neuritic branching and synapse formation in hippocampal neurons in vitro. However, its importance for hippocampal- dependent learning and memory in the mouse has not been examined. Here, elevated levels of Flotillin-1 in hippocampal tissue of mice trained in the Morris water maze confirmed the relevance of Flotillin-1 for memory-related processes in a mammalian system. Thus, a translational approach-from invertebrates to rodents-led to the identification of Flotillin-1 as evolutionary-conserved memory-related protein.

Environmental issues and competitiveness of district heating systems

International Nuclear Information System (INIS)

Kypreos, S.

1991-01-01

The advantages of district heating systems are evaluated in competition to individual heating for the Swiss markets. The preservation of the environmental quality on the national (clean air concept) and global scale (Toronto recommendation) is formulated as constraint of the energy system. The implications of these constraints for the economic competition of district heating is evaluated. The study estimates the evolution of energy demand in the heating markets and shortly describes the technical possibilities in satisfying demand by a set of conventional heating systems, systems using renewable energy sources, energy conservation measures and district heating systems based on conventional or nuclear energy sources. The main conclusion is that small capacity nuclear district heating systems, if acceptable, could enhance the flexibility of the Swiss energy system in respect to CO 2 control. (author) 3 figs., 4 tabs., 9 refs

Mitochondrial regulation of cell death: a phylogenetically conserved control

Directory of Open Access Journals (Sweden)

Lorenzo Galluzzi

2016-02-01

Full Text Available Mitochondria are fundamental for eukaryotic cells as they participate in critical catabolic and anabolic pathways. Moreover, mitochondria play a key role in the signal transduction cascades that precipitate many (but not all regulated variants of cellular demise. In this short review, we discuss the differential implication of mitochondria in the major forms of regulated cell death.

Arabidopsis VASCULAR-RELATED UNKNOWN PROTEIN1 Regulates Xylem Development and Growth by a Conserved Mechanism That Modulates Hormone Signaling1[W][OPEN

Science.gov (United States)

Grienenberger, Etienne; Douglas, Carl J.

2014-01-01

Despite a strict conservation of the vascular tissues in vascular plants (tracheophytes), our understanding of the genetic basis underlying the differentiation of secondary cell wall-containing cells in the xylem of tracheophytes is still far from complete. Using coexpression analysis and phylogenetic conservation across sequenced tracheophyte genomes, we identified a number of Arabidopsis (Arabidopsis thaliana) genes of unknown function whose expression is correlated with secondary cell wall deposition. Among these, the Arabidopsis VASCULAR-RELATED UNKNOWN PROTEIN1 (VUP1) gene encodes a predicted protein of 24 kD with no annotated functional domains but containing domains that are highly conserved in tracheophytes. Here, we show that the VUP1 expression pattern, determined by promoter-β-glucuronidase reporter gene expression, is associated with vascular tissues, while vup1 loss-of-function mutants exhibit collapsed morphology of xylem vessel cells. Constitutive overexpression of VUP1 caused dramatic and pleiotropic developmental defects, including severe dwarfism, dark green leaves, reduced apical dominance, and altered photomorphogenesis, resembling brassinosteroid-deficient mutants. Constitutive overexpression of VUP homologs from multiple tracheophyte species induced similar defects. Whole-genome transcriptome analysis revealed that overexpression of VUP1 represses the expression of many brassinosteroid- and auxin-responsive genes. Additionally, deletion constructs and site-directed mutagenesis were used to identify critical domains and amino acids required for VUP1 function. Altogether, our data suggest a conserved role for VUP1 in regulating secondary wall formation during vascular development by tissue- or cell-specific modulation of hormone signaling pathways. PMID:24567189

Shifting liberal and conservative attitudes using moral foundations theory.

Science.gov (United States)

Day, Martin V; Fiske, Susan T; Downing, Emily L; Trail, Thomas E

2014-12-01

People's social and political opinions are grounded in their moral concerns about right and wrong. We examine whether five moral foundations--harm, fairness, ingroup, authority, and purity--can influence political attitudes of liberals and conservatives across a variety of issues. Framing issues using moral foundations may change political attitudes in at least two possible ways: (a) Entrenching: Relevant moral foundations will strengthen existing political attitudes when framing pro-attitudinal issues (e.g., conservatives exposed to a free-market economic stance) and (b) Persuasion: Mere presence of relevant moral foundations may also alter political attitudes in counter-attitudinal directions (e.g., conservatives exposed to an economic regulation stance). Studies 1 and 2 support the entrenching hypothesis. Relevant moral foundation-based frames bolstered political attitudes for conservatives (Study 1) and liberals (Study 2). Only Study 2 partially supports the persuasion hypothesis. Conservative-relevant moral frames of liberal issues increased conservatives' liberal attitudes. © 2014 by the Society for Personality and Social Psychology, Inc.

Caffeine Induces the Stress Response and Up-Regulates Heat Shock Proteins in Caenorhabditis elegans.

Science.gov (United States)

Al-Amin, Mohammad; Kawasaki, Ichiro; Gong, Joomi; Shim, Yhong-Hee

2016-02-01

Caffeine has both positive and negative effects on physiological functions in a dose-dependent manner. C. elegans has been used as an animal model to investigate the effects of caffeine on development. Caffeine treatment at a high dose (30 mM) showed detrimental effects and caused early larval arrest. We performed a comparative proteomic analysis to investigate the mode of action of high-dose caffeine treatment in C. elegans and found that the stress response proteins, heat shock protein (HSP)-4 (endoplasmic reticulum [ER] chaperone), HSP-6 (mitochondrial chaperone), and HSP-16 (cytosolic chaperone), were induced and their expression was regulated at the transcriptional level. These findings suggest that high-dose caffeine intake causes a strong stress response and activates all three stress-response pathways in the worms, including the ER-, mitochondrial-, and cytosolic pathways. RNA interference of each hsp gene or in triple combination retarded growth. In addition, caffeine treatment stimulated a food-avoidance behavior (aversion phenotype), which was enhanced by RNAi depletion of the hsp-4 gene. Therefore, up-regulation of hsp genes after caffeine treatment appeared to be the major responses to alleviate stress and protect against developmental arrest.

Heat shock modulates the subcellular localization, stability, and activity of HIPK2

International Nuclear Information System (INIS)

Upadhyay, Mamta; Bhadauriya, Pratibha; Ganesh, Subramaniam

2016-01-01

The homeodomain-interacting protein kinase-2 (HIPK2) is a highly conserved serine/threonine kinase and is involved in transcriptional regulation. HIPK2 is a highly unstable protein, and is kept at a low level under normal physiological conditions. However, exposure of cells to physiological stress – such as hypoxia, oxidative stress, or UV damage – is known to stabilize HIPK2, leading to the HIPK2-dependent activation of p53 and the cell death pathway. Therefore HIPK2 is also known as a stress kinase and as a stress-activated pro-apoptotic factor. We demonstrate here that exposure of cells to heat shock results in the stabilization of HIPK2 and the stabilization is mediated via K63-linked ubiquitination. Intriguingly, a sub-lethal heat shock (42 °C, 1 h) results in the cytoplasmic localization of HIPK2, while a lethal heat shock (45 °C, 1 h) results in its nuclear localization. Cells exposed to the lethal heat shock showed significantly higher levels of the p53 activity than those exposed to the sub-lethal thermal stress, suggesting that both the level and the nuclear localization are essential for the pro-apoptotic activity of HIPK2 and that the lethal heat shock could retain the HIPK2 in the nucleus to promote the cell death. Taken together our study underscores the importance of HIPK2 in stress mediated cell death, and that the HIPK2 is a generic stress kinase that gets activated by diverse set of physiological stressors.

Heat shock modulates the subcellular localization, stability, and activity of HIPK2

Energy Technology Data Exchange (ETDEWEB)

Upadhyay, Mamta; Bhadauriya, Pratibha; Ganesh, Subramaniam, E-mail: sganesh@iitk.ac.in

2016-04-15

The homeodomain-interacting protein kinase-2 (HIPK2) is a highly conserved serine/threonine kinase and is involved in transcriptional regulation. HIPK2 is a highly unstable protein, and is kept at a low level under normal physiological conditions. However, exposure of cells to physiological stress – such as hypoxia, oxidative stress, or UV damage – is known to stabilize HIPK2, leading to the HIPK2-dependent activation of p53 and the cell death pathway. Therefore HIPK2 is also known as a stress kinase and as a stress-activated pro-apoptotic factor. We demonstrate here that exposure of cells to heat shock results in the stabilization of HIPK2 and the stabilization is mediated via K63-linked ubiquitination. Intriguingly, a sub-lethal heat shock (42 °C, 1 h) results in the cytoplasmic localization of HIPK2, while a lethal heat shock (45 °C, 1 h) results in its nuclear localization. Cells exposed to the lethal heat shock showed significantly higher levels of the p53 activity than those exposed to the sub-lethal thermal stress, suggesting that both the level and the nuclear localization are essential for the pro-apoptotic activity of HIPK2 and that the lethal heat shock could retain the HIPK2 in the nucleus to promote the cell death. Taken together our study underscores the importance of HIPK2 in stress mediated cell death, and that the HIPK2 is a generic stress kinase that gets activated by diverse set of physiological stressors.

Refrigeration waste heat recovery

Energy Technology Data Exchange (ETDEWEB)

1983-03-01

UK Super A Stores was built in 1972 and is part of a small indoor shopping complex linked together by a heated mall. The store has a public floor area of approximately 1,232 m{sup 2} (13,261 ft.{sup 2}) and sells the usual variety of food produce including a large selection of frozen foods. There are five lengths of refrigerated display cabinets with a total area of approximately 78 m{sup 2}. There are also some frozen food storage rooms at the back of the store. This report provides a description of a waste heat recovery system within a medium sized food store. It details how the waste heat that is produced by the conventional frozen food display cabinets, can be reused by the store's space heating system. Recommended uses for this waste heat include: diverting to the loading bays which would make the reheat coil unnecessary, diverting to the front of the shop, and heating the adjacent shopping mall. The CREDA (Conservation and Renewable Energy Demonstration Assistance) program contributed $17,444 towards the total project cost of $30,444. The project was initiated by the store owner, who is now realizing a lower annual fuel consumption, with the resulting financial savings. 11 figs., 1 tab.

76 FR 27986 - Funding for the Conservation Loan Program; Farm Loan Programs

Science.gov (United States)

2011-05-13

... for the Conservation Loan Program; Farm Loan Programs AGENCY: Farm Service Agency, USDA. ACTION... or guaranteed loan applications for the Conservation Loan (CL) Program because of lack of program... provisions to the existing direct and guaranteed loan regulations found in 7 CFR parts 761, 762, 764, 765...

Energy conservation in the earth's crust and climate change.

Science.gov (United States)

Mu, Yao; Mu, Xinzhi

2013-02-01

Among various matters which make up the earth's crust, the thermal conductivity of coal, oil, and oil-gas, which are formed over a long period of geological time, is extremely low. This is significant to prevent transferring the internal heat of the earth to the thermal insulation of the surface, cooling the surface of the earth, stimulating biological evolution, and maintaining natural ecological balance as well. Fossil energy is thermal insulating layer in the earth's crust. Just like the function of the thermal isolation of subcutaneous fatty tissue under the dermis of human skin, it keeps the internal heat within the organism so it won't be transferred to the skin's surface and be lost maintaining body temperature at low temperatures. Coal, oil, oil-gas, and fat belong to the same hydrocarbons, and the functions of their thermal insulation are exactly the same. That is to say, coal, oil, and oil-gas are just like the earth's "subcutaneous fatty tissue" and objectively formed the insulation protection on earth's surface. This paper argues that the human large-scale extraction of fossil energy leads to damage of the earth's crust heat-resistant sealing, increasing terrestrial heat flow, or the heat flow as it is called, transferring the internal heat of the earth to Earth's surface excessively, and causing geotemperature and sea temperature to rise, thus giving rise to global warming. The reason for climate warming is not due to the expansion of greenhouse gases but to the wide exploitation of fossil energy, which destroyed the heat insulation of the earth's crust, making more heat from the interior of the earth be released to the atmosphere. Based on the energy conservation principle, the measurement of the increase of the average global temperature that was caused by the increase of terrestrial heat flow since the Industrial Revolution is consistent with practical data. This paper illustrates "pathogenesis" of climate change using medical knowledge. The

Neurotoxicity induced by arsenic in Gallus Gallus: Regulation of oxidative stress and heat shock protein response.

Science.gov (United States)

Zhao, Panpan; Guo, Ying; Zhang, Wen; Chai, Hongliang; Xing, Houjuan; Xing, Mingwei

2017-01-01

Arsenic, a naturally occurring heavy metal pollutant, is one of the functioning risk factors for neurological toxicity in humans. However, little is known about the effects of arsenic on the nervous system of Gallus Gallus. To investigate whether arsenic induce neurotoxicity and influence the oxidative stress and heat shock proteins (Hsps) response in chickens, seventy-two 1-day-old male Hy-line chickens were treated with different doses of arsenic trioxide (As 2 O 3 ). The histological changes, antioxidant enzyme activity, and the expressions of Hsps were detected. Results showed slightly histology changes were obvious in the brain tissues exposure to arsenic. The activities of Glutathione peroxidase (GSH-Px) and catalase (CAT) were decreased compared to the control, whereas the malondialdehyde (MDA) content was increased gradually along with increase in diet-arsenic. The mRNA levels of Hsps and protein expressions of Hsp60 and Hsp70 were up-regulated. These results suggested that sub-chronic exposure to arsenic induced neurotoxicity in chickens. Arsenic exposure disturbed the balance of oxidants and antioxidants. Increased heat shock response tried to protect chicken brain tissues from tissues damage caused by oxidative stress. The mechanisms of neurotoxicity induced by arsenic include oxidative stress and heat shock protein response in chicken brain tissues. Copyright © 2016 Elsevier Ltd. All rights reserved.

15 CFR 971.502 - Conservation of resources.

Science.gov (United States)

2010-01-01

... ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR COMMERCIAL RECOVERY PERMITS Resource Development... restrictions relating to conservation of resources, he will employ a balancing process in the consideration of... potential use of any waste, the environmental effects of the recovery activities, economic and resource data...

Microeconomics and the demand for space heating

Energy Technology Data Exchange (ETDEWEB)

Fisk, D.J.

1977-12-01

The techniques of economic utility theory are combined with the technical equations for heat loss from a dwelling to give insight into the variation of consumer demand for space heating. A theoretical relationship is established between the performance of the occupied dwelling as the external temperature falls and the short-run income elasticity of energy demand. The analysis is applied to studies of UK heating practice in the 1950s and the implied indifference map for thermal comfort deduced. This indifference map is found to show a considerable economic propensity to absorb some of the potential savings from energy conservation measurements in higher internal temperatures. The effect found is sufficiently large to have consequences for future energy planning if it were still present in the UK domestic sector. The analysis highlights a number of points that should aid the interpretation of field experiments on domestic energy consumption. In particular, it is shown that unless great care is taken to separate out the technical and economic origins of internal temperature variation, the results of field studies on the effectiveness of conservation techniques may only be of shortlived value.

Heating of roads. Heat consumption and heat output as a function of climate, construction, demands on surface conditions and principle of heat supply. Uppvaermning av vaegar

Energy Technology Data Exchange (ETDEWEB)

Magnusson, R

1977-01-01

In this work analytical formulas for calculation of temperatures in a heated roadbed are given. The heat flux from a heated surface has been studied. The methods for snowclearence on different types of roads have been investigated. The construction work has been studied. The analytical formulas have been evaluated by comparison between calculated temperatures and temperatures measured in field and laboratory. The heat transfer coefficients in those formulas have been developed empirically by tests in laboratory and field. Surfaces with different types of traffic are divided into three classes according to the demands for snow removal. The construction work has been divided into cost elements. This has given a basis for calculating the economic effects of alternative designs. By this work has been developed a method useful on one hand for calculation of the optimum principle of regulation of the supply of heat and on the other hand for the design of the heat installations in the road.

Preliminary guidelines for electricity distributor conservation and demand management activities : a guide for conservation and demand management investment

International Nuclear Information System (INIS)

2004-01-01

In May 2004, electricity distributors in Ontario were asked to submit deferral accounts to the Ontario Energy Board to track expenditures on conservation and demand management initiatives. The deferral accounts must be established before the distributor could recover the costs through the next installment of the allowable return on equity in March 2004. The Board will determine the appropriateness of the actual expenditures. These guidelines offer short-term assistance to distributors in establishing conservation and demand management plans and initiatives. The following specific measures may be supported by the Board: energy efficiency; operational changes to smart control systems; load management measures which facilitate interruptible and dispatchable loads, dual fuel applications, thermal storage and demand response; fuel switching measures; programs targeted to low income and hard to reach consumers; and, distributed energy options such as tri-generation, cogeneration, ground source heat pumps, wind and biomass systems. These guidelines described the regulatory treatment of conservation and demand management investments along with cost effectiveness, allocation of costs, monitoring, evaluation, and implementation. 1 appendix

Heat generation by a wind turbine

Energy Technology Data Exchange (ETDEWEB)

Corten, G.P. [ECN Wind, Petten (Netherlands)

2001-01-01

It will be shown that an actuator disk operating in wind turbine mode extracts more energy from the fluid than can be transferred into useful energy. At the Lanchester-Betz limit the decrease of the kinetic energy in the wind is converted by 2 /3 into useful power and by 1 /3 into heat. Behind the wind turbine the outer flow and the flow that has passed the actuator disk will mix. In this process momentum is conserved but part of the kinetic energy will dissipate in heat via viscous shear. 7 refs.

Energy conservation behavioural intention: attitudes, subjective norm and self-efficacy

Science.gov (United States)

Lee, J. W. C.; Tanusia, A.

2016-08-01

This paper examines the influence of attitude towards energy conservation at home, the attitude in the campus, subjective norm, and self-efficacy on energy conservation behavioural intention among students in a private university using the Theory of Planned Behaviour (TPB). Data was collected from about 194 students using a questionnaire developed from current literature on TPB. Data analysis using Smart PLS version 3.2.4 found that attitude towards energy conservation at home has an indirect significant influence on attitude towards energy conservation behavioural intention via the mediating effect of attitude towards energy conservation in the campus. Self-efficacy and subjective norm are also positively related to energy conservation intention. The study also indicates the suitability of the TPB in predicting behavioural intention through attitudes, subjective norms, and self-efficacy. Results suggest that energy education is vital in creating a positive attitude towards energy conservation while facilities managers in institutions need to formulate appropriate policies and regulations to inculcate the right attitude and behaviour towards energy saving.

Global environmental benefits of industrial heat pumps (fiscal 1993); 1993 nendo koon heat pumping gijutsu ni yoru chikyu ondanka keigen koka ni kansuru chosa kenkyu hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-03-01

An investigational study was conducted aiming at making a quantitative grasp of effects of the spread of industrial heat pumps on energy conservation and greenhouse gas reduction and at promoting the spread. Finally, the following eight countries joined this international joint research: Canada, France, Japan, Holland, Norway, Sweden, the U.K. and the U.S. Each country share the work and expenses for the research with each other. Japan made investigational researches on the application of heat pumps to processes of the chemical industry, oil refining industry, food industry, paper/pulp industry, and dyeing/weaving industry, and on the effects of greenhouse gas reduction. As procedures taken, values up to 2010 were estimated of energy prices in each country, energy supply/demand, rates of the heat source configuration for electric power supply, etc., the heat flow of the above-mentioned process was made clear, and analyses were conducted of annual profits, energy consumption, and depreciation period in the case of adopting heat pumps. Moreover, the energy conservation amount and greenhouse effect gas reduction amount were estimated based on the result of the analyses. 69 figs., 196 tabs.

Large break LOCA uncertainty evaluation and comparison with conservative calculation

International Nuclear Information System (INIS)

Glaeser, H.G.

2004-01-01

The first formulation of the USA Code of Federal Regulations (CFR) 10CFR50 with applicable sections specific to NPP licensing requirements was released 1976. Over a decade later 10CFR 50.46 allowed the use of BE codes instead of conservative code models but uncertainties have to be identified and quantified. Guidelines were released that described interpretations developed over the intervening years that are applicable. Other countries established similar conservative procedures and acceptance criteria. Because conservative methods were used to calculate the peak values of key parameters, such as peak clad temperature (PCT), it was always acknowledged that a large margin, between the 'conservative' calculated value and the 'true' value, existed. Beside USA, regulation in other countries, like Germany, for example, allowed that the state of science and technology is applied in licensing. I.e. the increase of experimental evidence and progress in code development during time could be used. There was no requirement to apply a pure evaluation methodology with licensed assumptions and frozen codes. The thermal-hydraulic system codes became more and more best-estimate codes based on comprehensive validation. This development was and is possible because the rules and guidelines provide the necessary latitude to consider further development of safety technology. Best estimate codes are allowed to be used in licensing in combination with conservative initial and boundary conditions. However, uncertainty quantification is not required. Since some of the initial and boundary conditions are more conservative compared with those internationally used (e.g. 106% reactor power instead 102%, a single failure plus a non-availability due to preventive maintenance is assumed, etc.) it is claimed that the uncertainties of code models are covered. Since many utilities apply for power increase, calculation results come closer to some licensing criteria. The situation in German licensing

Expression analysis of a heat-inducible, Myo-inositol-1-phosphate synthase (MIPS) gene from wheat and the alternatively spliced variants of rice and Arabidopsis.

Science.gov (United States)

Khurana, Neetika; Chauhan, Harsh; Khurana, Paramjit

2012-01-01

Molecular dissection and a deeper analysis of the heat stress response mechanism in wheat have been poorly understood so far. This study delves into the molecular basis of action of TaMIPS, a heat stress-inducible enzyme that was identified through PCR-select subtraction technology, which is named here as TaMIPS2. MIPS (L-Myo-inositol-phosphate synthase) is important for the normal growth and development in plants. Expression profiling showed that TaMIPS2 is expressed during different developing seed stages upon heat stress. Also, the transcript levels increase in unfertilized ovaries and significant amounts are present during the recovery period providing evidence that MIPS is crucial for its role in heat stress recovery and flower development. Alternatively spliced forms from rice and Arabidopsis were also identified and their expression analysis revealed that apart from heat stress, some of the spliced variants were also inducible by drought, NaCl, Cold, ABA, BR, SA and mannitol. In silico promoter analysis revealed various cis-elements that could contribute for the differential regulation of MIPS in different plant systems. Phylogenetic analysis indicated that MIPS are highly conserved among monocots and dicots and TaMIPS2 grouped specifically with monocots. Comparative analyses was undertaken by different experimental approaches, i.e., semi-quantitative RT-PCR, quantitative RT-PCR, Genevestigator as a reference expression tool and motif analysis to predict the possible function of TaMIPS2 in regulating the different aspects of plant development under abiotic stress in wheat.

Curli Fibers Are Highly Conserved between Salmonella typhimurium and Escherichia coli with Respect to Operon Structure and Regulation

Science.gov (United States)

Römling, Ute; Bian, Zhao; Hammar, Mårten; Sierralta, Walter D.; Normark, Staffan

1998-01-01

Mouse-virulent Salmonella typhimurium strains SR-11 and ATCC 14028-1s express curli fibers, thin aggregative fibers, at ambient temperature on plates as judged by Western blot analysis and electron microscopy. Concomitantly with curli expression, cells develop a rough and dry colony morphology and bind the dye Congo red (called the rdar morphotype). Cloning and characterization of the two divergently transcribed operons required for curli biogenesis, csgBA(C) and csgDEFG, from S. typhimurium SR-11 revealed the same gene order and flanking genes as in Escherichia coli. The divergence of the curli region between S. typhimurium and E. coli at the nucleotide level is above average (22.4%). However, a high level of conservation at the protein level, which ranged from 86% amino acid homology for the fiber subunit CsgA to 99% homology for the lipoprotein CsgG, implies functional constraints on the gene products. Consequently, S. typhimurium genes on low-copy-number plasmids were able to complement respective E. coli mutants, although not always to wild-type levels. rpoS and ompR are required for transcriptional activation of (at least) the csgD promoter. The high degree of conservation at the protein level and the identical regulation patterns in E. coli and S. typhimurium suggest similar roles of curli fibers in the same ecological niche in the two species. PMID:9457880

Genome-wide identification and analysis of biotic and abiotic stress regulation of small heat shock protein (HSP20) family genes in bread wheat.

Science.gov (United States)

Muthusamy, Senthilkumar K; Dalal, Monika; Chinnusamy, Viswanathan; Bansal, Kailash C

2017-04-01

Small Heat Shock Proteins (sHSPs)/HSP20 are molecular chaperones that protect plants by preventing protein aggregation during abiotic stress conditions, especially heat stress. Due to global climate change, high temperature is emerging as a major threat to wheat productivity. Thus, the identification of HSP20 and analysis of HSP transcriptional regulation under different abiotic stresses in wheat would help in understanding the role of these proteins in abiotic stress tolerance. We used sequences of known rice and Arabidopsis HSP20 HMM profiles as queries against publicly available wheat genome and wheat full length cDNA databases (TriFLDB) to identify the respective orthologues from wheat. 163 TaHSP20 (including 109 sHSP and 54 ACD) genes were identified and classified according to the sub-cellular localization and phylogenetic relationship with sequenced grass genomes (Oryza sativa, Sorghum bicolor, Zea mays, Brachypodium distachyon and Setaria italica). Spatio-temporal, biotic and abiotic stress-specific expression patterns in normalized RNA seq and wheat array datasets revealed constitutive as well as inductive responses of HSP20 in different tissues and developmental stages of wheat. Promoter analysis of TaHSP20 genes showed the presence of tissue-specific, biotic, abiotic, light-responsive, circadian and cell cycle-responsive cis-regulatory elements. 14 TaHSP20 family genes were under the regulation of 8 TamiRNA genes. The expression levels of twelve HSP20 genes were studied under abiotic stress conditions in the drought- and heat-tolerant wheat genotype C306. Of the 13 TaHSP20 genes, TaHSP16.9H-CI showed high constitutive expression with upregulation only under salt stress. Both heat and salt stresses upregulated the expression of TaHSP17.4-CI, TaHSP17.7A-CI, TaHSP19.1-CIII, TaACD20.0B-CII and TaACD20.6C-CIV, while TaHSP23.7-MTI was specifically induced only under heat stress. Our results showed that the identified TaHSP20 genes play an important role under

Stable solutions of nonlocal electron heat transport equations

International Nuclear Information System (INIS)

Prasad, M.K.; Kershaw, D.S.

1991-01-01

Electron heat transport equations with a nonlocal heat flux are in general ill-posed and intrinsically unstable, as proved by the present authors [Phys. Fluids B 1, 2430 (1989)]. A straightforward numerical solution of these equations will therefore lead to absurd results. It is shown here that by imposing a minimal set of constraints on the problem it is possible to arrive at a globally stable, consistent, and energy conserving numerical solution

Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling.

Science.gov (United States)

Carvajal-Gonzalez, Jose Maria; Roman, Angel-Carlos; Mlodzik, Marek

2016-03-29

Planar cell polarity (PCP) signalling is a well-conserved developmental pathway regulating cellular orientation during development. An evolutionarily conserved pathway readout is not established and, moreover, it is thought that PCP mediated cellular responses are tissue-specific. A key PCP function in vertebrates is to regulate coordinated centriole/cilia positioning, a function that has not been associated with PCP in Drosophila. Here we report instructive input of Frizzled-PCP (Fz/PCP) signalling into polarized centriole positioning in Drosophila wings. We show that centrioles are polarized in pupal wing cells as a readout of PCP signalling, with both gain and loss-of-function Fz/PCP signalling affecting centriole polarization. Importantly, loss or gain of centrioles does not affect Fz/PCP establishment, implicating centriolar positioning as a conserved PCP-readout, likely downstream of PCP-regulated actin polymerization. Together with vertebrate data, these results suggest a unifying model of centriole/cilia positioning as a common downstream effect of PCP signalling from flies to mammals.

Biomass fuels in district heating systems. Final report. Biobrensel i fjernvarmesystem. Sluttrapport

Energy Technology Data Exchange (ETDEWEB)

Otterstad, B.

1987-02-01

The report deals with an energy conservation project on district heating. The project gives a cost comparison between a biomass fuelled system for the local water heating/electric power supply and the development of hydroelectric power. The computer program ESENTRAL is used in the simulation. 3 drawings.

Implementation of heat production and storage technology and devices in power systems

International Nuclear Information System (INIS)

Romanovsky, G.; Mutale, J.

2012-01-01

Implementation of heat storage devices and technologies at power generation plants is a promising way to provide more efficient use of natural energy resources. Heat storage devices can partly replace conventional heating technologies (such as direct use of fossil fuels) during peak energy demand or in the situations where heat and electricity supply and demand do not coincide and to obtain low cost heat energy which can be further transmitted to industrial, commercial and domestic consumers. This paper presents the innovative Heat Production and Storage Device and its application at conventional, nuclear and renewable power generation plants for optimization and balancing of electricity grids. The Heat Production and Storage Device is a vessel type induction-immersion heat production and storage device which produces pre-heated water under pressure for heat energy conservation. Operation of this device is based on simultaneous and/or sequential action of an inductor and an immersion heater and can be easily connected to the electricity network as a single or a three phase unit. Heat energy accumulated by the Heat Production and Storage Device can be utilized in different industrial technological processes during periods of high energy prices. - Highlights: ► Heat Production and Storage Device for energy conservation within low load hours. ► Simultaneous and/or sequential operation of the inductor and immersion heater. ► Transform the energy of low frequency electrical current (50 Hz) into heat energy. ► Connection to the electricity network either in single or three phase unit. ► Heat Production and Storage Device will enhance the economic value of the system.

Paradigm shifts in fish conservation: moving to the ecosystem services concept.

Science.gov (United States)

Cowx, I G; Portocarrero Aya, M

2011-12-01

Various factors constrain the existence and development of inland fishes and fisheries, such as pollution, habitat degradation, alien invasive species, local user conflicts, low social priority and inadequate research and funding. In many cases, however, degradation of the environment and loss of aquatic habitat are the predominant concerns for the conservation of freshwater aquatic biota. The need for concerted effort to prevent and reduce environmental degradation, as well as protection of freshwater fishes and fisheries as renewable common pool resources or entities in their own right, are the greatest challenges facing the conservation of fishes in inland waters. Unfortunately, traditional conservation practices such as regulation of exploitation, protected areas and habitat restoration have failed to arrest the alarming increase in number of threatened freshwater fish species worldwide. This paper examines the shifting paradigm of fisheries management from rule-based regulation, through fishery enhancement towards the ecosystem approach to fisheries, with reference to inland waters, and how the emerging concept of ecosystem services coupled with traditional fish conservation management practices, institutional restructuring and integrated management planning should provide a more sustainable thrust to formulation and promotion of fish conservation initiatives. © 2011 The Authors. Journal of Fish Biology © 2011 The Fisheries Society of the British Isles.

46 CFR 153.430 - Heat transfer systems; general.

Science.gov (United States)

2010-10-01

... 46 Shipping 5 2010-10-01 2010-10-01 false Heat transfer systems; general. 153.430 Section 153.430... Temperature Control Systems § 153.430 Heat transfer systems; general. Each cargo cooling system required by... separated from all other cooling and heating systems; and (c) Allow manual regulation of the system's heat...

Heat Transport in Gapped Spin-Chain Systems

International Nuclear Information System (INIS)

Shimshoni, E.

2006-01-01

Full Text: We study the contribution of magnetic excitations to the heat transport in gapped spin-chain systems. These systems are characterized by a substantially enhanced heat conductivity, which can be traced back to the existence of weakly violated conservation laws. We focus particularly on the behavior of clean two-leg spin ladder compounds, where one-dimensional exotic spin excitations are coupled to three-dimensional phonons. We show that the contributions of the two types of heat carriers can not be easily disentangled. Depending on the ratios of spin gaps and the Debye energy, the heat conductivity can be either exponentially increasing or exponentially decreasing as a function of temperature (T). In addition, the magnetic contribution to the total heat conductivity may be either positive or negative. We discuss its T-dependence in various possible regimes, and note that in most regimes it is dominated by spin-phonon drag: the two types of heat carriers have almost the

Nonlinear Conservation Laws and Finite Volume Methods

Science.gov (United States)

Leveque, Randall J.

Introduction Software Notation Classification of Differential Equations Derivation of Conservation Laws The Euler Equations of Gas Dynamics Dissipative Fluxes Source Terms Radiative Transfer and Isothermal Equations Multi-dimensional Conservation Laws The Shock Tube Problem Mathematical Theory of Hyperbolic Systems Scalar Equations Linear Hyperbolic Systems Nonlinear Systems The Riemann Problem for the Euler Equations Numerical Methods in One Dimension Finite Difference Theory Finite Volume Methods Importance of Conservation Form - Incorrect Shock Speeds Numerical Flux Functions Godunov's Method Approximate Riemann Solvers High-Resolution Methods Other Approaches Boundary Conditions Source Terms and Fractional Steps Unsplit Methods Fractional Step Methods General Formulation of Fractional Step Methods Stiff Source Terms Quasi-stationary Flow and Gravity Multi-dimensional Problems Dimensional Splitting Multi-dimensional Finite Volume Methods Grids and Adaptive Refinement Computational Difficulties Low-Density Flows Discrete Shocks and Viscous Profiles Start-Up Errors Wall Heating Slow-Moving Shocks Grid Orientation Effects Grid-Aligned Shocks Magnetohydrodynamics The MHD Equations One-Dimensional MHD Solving the Riemann Problem Nonstrict Hyperbolicity Stiffness The Divergence of B Riemann Problems in Multi-dimensional MHD Staggered Grids The 8-Wave Riemann Solver Relativistic Hydrodynamics Conservation Laws in Spacetime The Continuity Equation The 4-Momentum of a Particle The Stress-Energy Tensor Finite Volume Methods Multi-dimensional Relativistic Flow Gravitation and General Relativity References

Soil physical properties regulate lethal heating during burning of woody residues

Science.gov (United States)

Matt Busse; Carol Shestak; Ken Hubbert; Eric Knapp

2010-01-01

Temperatures well in excess of the lethal threshold for roots (60°C) have been measured in forest soils when woody fuels are burned. Whether this heat pulse is strongly moderated by soil moisture or soil texture is not fully understood, however. We measured soil heat profi les during 60 experimental burns, identifying changes in maximum soil temperature and heat...

Energy conservation and cost benefits in the dairy processing industry

Energy Technology Data Exchange (ETDEWEB)

None

1982-01-01

Guidance is given on measuring energy consumption in the plant and pinpointing areas where energy-conservation activities can return the most favorable economics. General energy-conservation techniques applicable to most or all segments of the dairy processing industry, including the fluid milk segment, are emphasized. These general techniques include waste heat recovery, improvements in electric motor efficiency, added insulation, refrigeration improvements, upgrading of evaporators, and increases in boiler efficiency. Specific examples are given in which these techniques are applied to dairy processing plants. The potential for energy savings by cogeneration of process steam and electricity in the dairy industry is also discussed. Process changes primarily applicable to specific milk products which have resulted in significant energy cost savings at some facilities or which promise significant contributions in the future are examined. A summary checklist of plant housekeeping measures for energy conservation and guidelines for economic evaluation of conservation alternatives are provided. (MHR)

Conservation of Charge and Conservation of Current

OpenAIRE

Eisenberg, Bob

2016-01-01

Conservation of current and conservation of charge are nearly the same thing: when enough is known about charge movement, conservation of current can be derived from conservation of charge, in ideal dielectrics, for example. Conservation of current is enforced implicitly in ideal dielectrics by theories that conserve charge. But charge movement in real materials like semiconductors or ionic solutions is never ideal. We present an apparently universal derivation of conservation of current and ...

Integrated multiscale simulation of combined heat and power based district heating system

International Nuclear Information System (INIS)

Li, Peifeng; Nord, Natasa; Ertesvåg, Ivar Ståle; Ge, Zhihua; Yang, Zhiping; Yang, Yongping

2015-01-01

Highlights: • Simulation of power plant, district heating network and heat users in detail and integrated. • Coupled calculation and analysis of the heat and pressure losses of the district heating network. • District heating is not preferable for very low heat load due to relatively high heat loss. • Lower design supply temperatures of the district heating network give higher system efficiency. - Abstract: Many studies have been carried out separately on combined heat and power and district heating. However, little work has been done considering the heat source, the district heating network and the heat users simultaneously, especially when it comes to the heating system with large-scale combined heat and power plant. For the purpose of energy conservation, it is very important to know well the system performance of the integrated heating system from the very primary fuel input to the terminal heat users. This paper set up a model of 300 MW electric power rated air-cooled combined heat and power plant using Ebsilon software, which was validated according to the design data from the turbine manufacturer. Then, the model of heating network and heat users were developed based on the fundamental theories of fluid mechanics and heat transfer. Finally the combined heat and power based district heating system was obtained and the system performances within multiscale scope of the system were analyzed using the developed Ebsilon model. Topics with regard to the heat loss, the pressure drop, the pump power consumption and the supply temperatures of the district heating network were discussed. Besides, the operational issues of the integrated system were also researched. Several useful conclusions were drawn. It was found that a lower design primary supply temperature of the district heating network would give a higher seasonal energy efficiency of the integrated system throughout the whole heating season. Moreover, it was not always right to relate low design

Economic evaluation of investment in electricity conservation

International Nuclear Information System (INIS)

Becker, Nir; Fishman, Yaron; Lavee, Doron

2008-01-01

The paper presents an economic study of the potential for energy conservation in Israel. We analyze energy conservation policies targeted at the household sector, focusing on the economic feasibility of scrapping old household electrical appliances, and considering the effect of such policies at both the household and the macro-economic level. The results of our analysis show that the appliance that provides the most potential conservation is the air conditioner (used for both heating and cooling). A scrapping program for old air conditioners passes a cost benefit analysis (CBA) even when external benefits are excluded from the calculation. When external benefits are included, scrapping programs for both washing machines and dishwashers pass the test as well. According to our findings, the annual economic benefit of a program involving the scrapping of 100,000 air conditioners, 45,000 washing machines and 15,000 dishwashers per annum over 10 years ranges from 246 million New Israeli Shekels (NIS) in the first year of implementation to 693 million in the tenth year. Most of the savings are derived from the scrapping of air conditioners

Human developmental enhancers conserved between deuterostomes and protostomes.

Directory of Open Access Journals (Sweden)

Shoa L Clarke

Full Text Available The identification of homologies, whether morphological, molecular, or genetic, is fundamental to our understanding of common biological principles. Homologies bridging the great divide between deuterostomes and protostomes have served as the basis for current models of animal evolution and development. It is now appreciated that these two clades share a common developmental toolkit consisting of conserved transcription factors and signaling pathways. These patterning genes sometimes show common expression patterns and genetic interactions, suggesting the existence of similar or even conserved regulatory apparatus. However, previous studies have found no regulatory sequence conserved between deuterostomes and protostomes. Here we describe the first such enhancers, which we call bilaterian conserved regulatory elements (Bicores. Bicores show conservation of sequence and gene synteny. Sequence conservation of Bicores reflects conserved patterns of transcription factor binding sites. We predict that Bicores act as response elements to signaling pathways, and we show that Bicores are developmental enhancers that drive expression of transcriptional repressors in the vertebrate central nervous system. Although the small number of identified Bicores suggests extensive rewiring of cis-regulation between the protostome and deuterostome clades, additional Bicores may be revealed as our understanding of cis-regulatory logic and sample of bilaterian genomes continue to grow.

Increasing participation in incentive programs for biodiversity conservation.

Science.gov (United States)

Sorice, Michael G; Oh, Chi-Ok; Gartner, Todd; Snieckus, Mary; Johnson, Rhett; Donlan, C Josh

2013-07-01

Engaging private landowners in conservation activities for imperiled species is critical to maintaining and enhancing biodiversity. Market-based approaches can incentivize conservation behaviors on private lands by shifting the benefit-cost ratio of engaging in activities that result in net conservation benefits for target species. In the United States and elsewhere, voluntary conservation agreements with financial incentives are becoming an increasingly common strategy. While the influence of program design and delivery of voluntary conservation programs is often overlooked, these aspects are critical to achieving the necessary participation to attain landscape-scale outcomes. Using a sample of family-forest landowners in the southeast United States, we show how preferences for participation in a conservation program to protect an at-risk species, the gopher tortoise (Gopherus polyphemus), are related to program structure, delivery, and perceived efficacy. Landowners were most sensitive to programs that are highly controlling, require permanent conservation easements, and put landowners at risk for future regulation. Programs designed with greater levels of compensation and that support landowners' autonomy to make land management decisions can increase participation and increase landowner acceptance of program components that are generally unfavorable, like long-term contracts and permanent easements. There is an inherent trade-off between maximizing participation and maximizing the conservation benefits when designing a conservation incentive program. For conservation programs targeting private lands to achieve landscape-level benefits, they must attract a critical level of participation that creates a connected mosaic of conservation benefits. Yet, programs with attributes that strive to maximize conservation benefits within a single agreement (and reduce risks of failure) are likely to have lower participation, and thus lower landscape benefits. Achieving

SSH analysis of endosperm transcripts and characterization of heat stress regulated expressed sequence tags in bread wheat

Directory of Open Access Journals (Sweden)

Suneha Goswami

2016-08-01

Full Text Available Heat stress is one of the major problems in agriculturally important cereal crops, especially wheat. Here, we have constructed a subtracted cDNA library from the endosperm of HS-treated (42°C for 2 h wheat cv. HD2985 by suppression subtractive hybridization (SSH. We identified ~550 recombinant clones ranging from 200 to 500 bp with an average size of 300 bp. Sanger’s sequencing was performed with 205 positive clones to generate the differentially expressed sequence tags (ESTs. Most of the ESTs were observed to be localized on the long arm of chromosome 2A and associated with heat stress tolerance and metabolic pathways. Identified ESTs were BLAST search using Ensemble, TriFLD and TIGR databases and the predicted CDS were translated and aligned with the protein sequences available in pfam and InterProScan 5 databases to predict the differentially expressed proteins (DEPs. We observed eight different types of post-translational modifications (PTMs in the DEPs corresponds to the cloned ESTs—147 sites with phosphorylation, 21 sites with sumoylation, 237 with palmitoylation, 96 sites with S-nitrosylation, 3066 calpain cleavage sites, and 103 tyrosine nitration sites, predicted to sense the heat stress and regulate the expression of stress genes. Twelve DEPs were observed to have transmembrane helixes (TMH in their structure, predicted to play the role of sensors of HS. Quantitative Real-Time PCR of randomly selected ESTs showed very high relative expression of HSP17 under HS; up-regulation was observed more in wheat cv. HD2985 (thermotolerant, as compared to HD2329 (thermosusceptible during grain-filling. The abundance of transcripts was further validated through northern blot analysis. The ESTs and their corresponding DEPs can be used as molecular marker for screening or targeted precision breeding program. PTMs identified in the DEPs can be used to elucidate the thermotolerance mechanism of wheat – a novel step towards the development of �

Drying apparatus with catalytic combustion of the exhaust gases and with heat recovery

Energy Technology Data Exchange (ETDEWEB)

Betz, E C

1975-11-20

The invention applies to a drying kiln whose charge is dried by a heating gas flow. In order to conserve energy, the thermal energy is transferred back from the catalytically oxydized exhaust gas flow to the heating gas flow. This is done by means of a heat exchanger which contains a heat transfer liquid whose pressure is set to make its boiling temperature the same as the maximum permissible heating gas temperature. The fuel supply to the heating gas burner is controlled by a temperature sensor across a control mechanism.

Rankine cycle waste heat recovery system

Science.gov (United States)

Ernst, Timothy C.; Nelson, Christopher R.

2014-08-12

This disclosure relates to a waste heat recovery (WHR) system and to a system and method for regulation of a fluid inventory in a condenser and a receiver of a Rankine cycle WHR system. Such regulation includes the ability to regulate the pressure in a WHR system to control cavitation and energy conversion.

Consumer energy conservation options - professional and consumer perspectives

Energy Technology Data Exchange (ETDEWEB)

Ritchie, B.J.R.; Claxton, J.D.; McDougall, G.H.G.

1980-01-01

The objectives of this study were to: identify government policies for reducing Canadian consumption of home heating fuel, electricity, and gasoline; assess probable effectiveness of different policy alternatives as a means of reducing consumer energy consumption; and measure the acceptability to Canadian consumers of the different policy alternatives. Interviews were conducted with energy conservation professionals to identify and evaluate existing energy conservation programs, and interviews were conducted with consumers who had evaluated selected programs previously reviewed by the professionals. Information was also gathered on energy conservation activities of consumers surveyed. A directory of 34 energy conservation programs was also compiled. Some of the conclusions reached in this report are as follows. There is a need for an information system to gather data on existing conservation programs in order to increase the knowledge of relevant parties as to the outcomes of operating programs. This would help evaluation and improvement of current programs and suggest new program possibilities. The professionals rated six of the 34 programs highly, including the Energuide and the Canadian Home Insulation Program (CHIP). Retrofitting programs for houses are recommended for continuation and expansion, with some consideration given to linking these kinds of programs with home audit programs. In the private transport sector, any new conservation programs should be thoroughly tested on a small scale before widespread implementation, as evidence indicates that certain programs favorably evaluated by professionals may not be received favorably by consumers. 3 refs., 24 tabs.

Alberta`s petroleum industry and the Conservation Board

Energy Technology Data Exchange (ETDEWEB)

Breen, D.H.

1993-12-31

The history of Alberta`s petroleum industry and Energy Resources Conservation Board (ERCB) was told. The conservation movement in Alberta was tracked from 1908 to the founding of the Petroleum and Natural Gas Conservation Board in 1938. Failure of Alberta`s first proration, and the Turner Valley `waste` gas conservation movement occurred during this period. The Leduc discovery and effects of the new regulatory environment on its development were discussed. The natural gas export debate, and the expansion of Alberta`s crude oil market were recounted in detail. The organization and regulation of field development which occurred during the period from 1948 to 1959 was presented. Past actions of the Petroleum and Natural Gas Conservation Board reviewed from today`s perspective. The petroleum industry and the ERCB were said to have been jointly responsible for the creation of a prosperous and confident new Alberta, moving it further and further away from the Canadian economic and political mainstream,, and reinforcing the sense of alienation that began to develop during the preceding agrarian decades. 53 figs., 48 tabs.

Post-Newtonian conservation laws in rigid quasilocal frames

International Nuclear Information System (INIS)

McGrath, Paul L; Chanona, Melanie; Epp, Richard J; Mann, Robert B; Koop, Michael J

2014-01-01

In recent work we constructed completely general conservation laws for energy (McGrath et al 2012 Class. Quantum Grav. 29 215012) and linear and angular momentum (Epp et al 2013 Class. Quantum Grav. 30 195019) of extended systems in general relativity based on the notion of a rigid quasilocal frame (RQF). We argued at a fundamental level that these RQF conservation laws are superior to conservation laws based on the local stress–energy–momentum tensor of matter because (1) they do not rely on spacetime symmetries and (2) they properly account for both matter and gravitational effects. Moreover, they provide simple, exact, operational expressions for fluxes of gravitational energy and linear and angular momentum. In this paper we derive the form of these laws in a general first post-Newtonian (1PN) approximation, and then apply these approximate laws to the problem of gravitational tidal interactions. We obtain formulas for tidal heating and tidal torque that agree with the literature, but without resorting to the use of pseudotensors. We describe the physical mechanism of these tidal interactions not in the traditional terms of a Newtonian gravitational force, but in terms of a much simpler and universal mechanism that is an exact, quasilocal manifestation of the equivalence principle in general relativity. As concrete examples, we look at the tidal heating of Jupiter’s moon Io and angular momentum transfer in the Earth–Moon system that causes a gradual spin-down of the Earth and recession of the Moon. In both examples we find agreement with observation. (paper)

Thermal conductance and basal metabolic rate are part of a coordinated system for heat transfer regulation

Science.gov (United States)

Naya, Daniel E.; Spangenberg, Lucía; Naya, Hugo; Bozinovic, Francisco

2013-01-01

Thermal conductance measures the ease with which heat leaves or enters  an organism's body. Although the analysis of this physiological variable in relation to climatic and ecological factors can be traced to studies by Scholander and colleagues, only small advances have occurred ever since. Here, we analyse the relationship between minimal thermal conductance estimated during summer (Cmin) and several ecological, climatic and geographical factors for 127 rodent species, in order to identify the exogenous factors that have potentially affected the evolution of thermal conductance. In addition, we evaluate whether there is compensation between Cmin and basal metabolic rate (BMR)—in such a way that a scale-invariant ratio between both variables is equal to one—as could be expected from the Scholander–Irving model of heat transfer. Our major findings are (i) annual mean temperature is the best single predictor of mass-independent Cmin. (ii) After controlling for the effect of body mass, there is a strong positive correlation between log10 (Cmin) and log10 (BMR). Further, the slope of this correlation is close to one, indicating an almost perfect compensation between both physiological variables. (iii) Structural equation modelling indicated that Cmin values are adjusted to BMR values and not the other way around. Thus, our results strongly suggest that BMR and thermal conductance integrate a coordinated system for heat regulation in endothermic animals and that summer conductance values are adjusted (in an evolutionary sense) to track changes in BMRs. PMID:23902915

Thermal conductance and basal metabolic rate are part of a coordinated system for heat transfer regulation.

Science.gov (United States)

Naya, Daniel E; Spangenberg, Lucía; Naya, Hugo; Bozinovic, Francisco

2013-09-22

Thermal conductance measures the ease with which heat leaves or enters an organism's body. Although the analysis of this physiological variable in relation to climatic and ecological factors can be traced to studies by Scholander and colleagues, only small advances have occurred ever since. Here, we analyse the relationship between minimal thermal conductance estimated during summer (Cmin) and several ecological, climatic and geographical factors for 127 rodent species, in order to identify the exogenous factors that have potentially affected the evolution of thermal conductance. In addition, we evaluate whether there is compensation between Cmin and basal metabolic rate (BMR)-in such a way that a scale-invariant ratio between both variables is equal to one-as could be expected from the Scholander-Irving model of heat transfer. Our major findings are (i) annual mean temperature is the best single predictor of mass-independent Cmin. (ii) After controlling for the effect of body mass, there is a strong positive correlation between log10 (Cmin) and log10 (BMR). Further, the slope of this correlation is close to one, indicating an almost perfect compensation between both physiological variables. (iii) Structural equation modelling indicated that Cmin values are adjusted to BMR values and not the other way around. Thus, our results strongly suggest that BMR and thermal conductance integrate a coordinated system for heat regulation in endothermic animals and that summer conductance values are adjusted (in an evolutionary sense) to track changes in BMRs.

KCNQ channels show conserved ethanol block and function in ethanol behaviour.

Directory of Open Access Journals (Sweden)

Sonia Cavaliere

Full Text Available In humans, KCNQ2/3 channels form an M-current that regulates neuronal excitability, with mutations in these channels causing benign neonatal familial convulsions. The M-current is important in mechanisms of neural plasticity underlying associative memory and in the response to ethanol, with KCNQ controlling the release of dopamine after ethanol exposure. We show that dKCNQ is broadly expressed in the nervous system, with targeted reduction in neuronal KCNQ increasing neural excitability and KCNQ overexpression decreasing excitability and calcium signalling, consistent with KCNQ regulating the resting membrane potential and neural release as in mammalian neurons. We show that the single KCNQ channel in Drosophila (dKCNQ has similar electrophysiological properties to neuronal KCNQ2/3, including conserved acute sensitivity to ethanol block, with the fly channel (IC(50 = 19.8 mM being more sensitive than its mammalian ortholog (IC(50 = 42.1 mM. This suggests that the role of KCNQ in alcohol behaviour can be determined for the first time by using Drosophila. We present evidence that loss of KCNQ function in Drosophila increased sensitivity and tolerance to the sedative effects of ethanol. Acute activation of dopaminergic neurons by heat-activated TRP channel or KCNQ-RNAi expression produced ethanol hypersensitivity, suggesting that both act via a common mechanism involving membrane depolarisation and increased dopamine signalling leading to ethanol sedation.

Model for Determining Geographical Distribution of Heat Saving Potentials in Danish Building Stock

Directory of Open Access Journals (Sweden)

Stefan Petrovic

2014-02-01

Full Text Available Since the global oil crisis in the 1970s, Denmark has followed a path towards energy independency by continuously improving its energy efficiency and energy conservation. Energy efficiency was mainly tackled by introducing a high number of combined heat and power plants in the system, while energy conservation was predominantly approached by implementing heat saving measures. Today, with the goal of 100% renewable energy within the power and heat sector by the year 2035, reductions in energy demand for space heating and the preparation of domestic hot water remain at the top of the agenda in Denmark. A highly detailed model for determining heat demand, possible heat savings and associated costs in the Danish building stock is presented. Both scheduled and energy-saving renovations until year 2030 have been analyzed. The highly detailed GIS-based heat atlas for Denmark is used as a container for storing data about physical properties for 2.5 million buildings in Denmark. Consequently, the results of the analysis can be represented on a single building level. Under the assumption that buildings with the most profitable heat savings are renovated first, the consequences of heat savings for the economy and energy system have been quantified and geographically referenced. The possibilities for further improvements of the model and the application to other geographical regions have been discussed.

A new method to calculate pressure drop and shell-side heat transfer coefficient in a shell-and-tube heat exchanger

International Nuclear Information System (INIS)

Baptista Filho, B.D.; Konuk, A.A.

1981-01-01

A new method to calculate pressure drop (Δp) and shell-side heat transfer coefficient (h sub(c)) in a shell-and-tube heat exchanger with segmental baffles is presented. The method is based on the solution of the equations of conservation of mass and momentum between two baffles. The calculated distributions of pressure and velocities given respectively, Δp and h sub(c). The values of Δp and h sub(c) are correlated for a given geometry whit the shell side fluid properties and flow rate. The calculated and experimental results agree very well for a U-Tube heat exchanger. (Author) [pt

The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception.

Science.gov (United States)

Nagy, Vanja; Cole, Tiffany; Van Campenhout, Claude; Khoung, Thang M; Leung, Calvin; Vermeiren, Simon; Novatchkova, Maria; Wenzel, Daniel; Cikes, Domagoj; Polyansky, Anton A; Kozieradzki, Ivona; Meixner, Arabella; Bellefroid, Eric J; Neely, G Gregory; Penninger, Josef M

2015-01-01

PR homology domain-containing member 12 (PRDM12) belongs to a family of conserved transcription factors implicated in cell fate decisions. Here we show that PRDM12 is a key regulator of sensory neuronal specification in Xenopus. Modeling of human PRDM12 mutations that cause hereditary sensory and autonomic neuropathy (HSAN) revealed remarkable conservation of the mutated residues in evolution. Expression of wild-type human PRDM12 in Xenopus induced the expression of sensory neuronal markers, which was reduced using various human PRDM12 mutants. In Drosophila, we identified Hamlet as the functional PRDM12 homolog that controls nociceptive behavior in sensory neurons. Furthermore, expression analysis of human patient fibroblasts with PRDM12 mutations uncovered possible downstream target genes. Knockdown of several of these target genes including thyrotropin-releasing hormone degrading enzyme (TRHDE) in Drosophila sensory neurons resulted in altered cellular morphology and impaired nociception. These data show that PRDM12 and its functional fly homolog Hamlet are evolutionary conserved master regulators of sensory neuronal specification and play a critical role in pain perception. Our data also uncover novel pathways in multiple species that regulate evolutionary conserved nociception.

Feasibility study on energy conservation and environmental improvement at Pakistan Steel

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

Feasibility study on energy conservation and environmental improvement was carried out with the aim of considering the realization of the CDM (clean development mechanism) project for reduction of global warming gas emissions and contributing to the environmental improvement and economic growth in Pakistan. In the study, projects on the following were studied: coke oven coal moisture control (CMC), sinter cooler waste heat recovery, blast furnace hot stove waste heat recovery, blast furnace pulverized coal injection (PCI), blast furnace top pressure recovery turbine (TRT), hot strip mill reheating furnace regenerative type burner, coke oven environmental improvement, and blast furnace cast house dust collection. As a result of the study, the implementation of the following three projects was regarded as promising in terms of energy conservation and economical effects: blast furnace pulverized coal injection, blast furnace top pressure recovery turbine and hot strip mill reheating furnace regenerative type burner. Further, the reduction in poisonous gas by the coke oven environmental improvement project was made a top priority. In Pakistan, the price of energy is kept low, and therefore, effects of energy conservation projects are not very much expected. However, the PCI project has an effect of substitution of low-priced domestic coal for imported coal. (NEDO)

Low-temperature heating systems and public administration

Energy Technology Data Exchange (ETDEWEB)

Boerner, H

1981-06-01

The even temperature distribution and comfortable climate in rooms heated by low-temperature heating systems is mostly due to one of the preconditions of this type of heating system namely, efficient thermal insulation of the rooms. Thermal insulation is already required as part of the pertinent legal regulations but it is also in the interest of the builder-owner as it will, in the long run, greatly reduce the heating cost.

Algorithms and programs for solution of static and dynamic characteristics of counterflow heat exchangers with dissociating coolant

International Nuclear Information System (INIS)

Nitej, N.V.; Sharovarov, G.A.

1982-01-01

The method of estimation of counterflow heat exchanger characteristics is presented. Mathematical description of the processes is presented by the mass, energy and pulse conservation equations for both coolants and energy conservation equation for the wall which devides them. In the presence of chemical reactions the system is supplemented by equations, characterizing the kinetics of their progress. The methods of numerical solution of static and dynamic problems have been chosen, and the computer programs on the Fortran language have been developed. The schemes of solution of both problems are so constructed, that the conservation equations are placed in the main program, and such characteristics of the coolants as properties, heat transfer and friction coefficients, the mechanism of chemical reaction are concentrated in the subprogram unit. This allows to create the single method of solution with the flow of single-phase and two-phase coolants of abovecritical and supercritical paramters. The evaluation results of three heat exchangers are given: with heating of N 2 O 4 gas phase by heat of flue gas; with cooling of N 2 O 4 supercritical parameters by water; regenerator on N 2 O 4

Mediator Recruitment to Heat Shock Genes Requires Dual Hsf1 Activation Domains and Mediator Tail Subunits Med15 and Med16*

Science.gov (United States)

Kim, Sunyoung; Gross, David S.

2013-01-01

The evolutionarily conserved Mediator complex is central to the regulation of gene transcription in eukaryotes because it serves as a physical and functional interface between upstream regulators and the Pol II transcriptional machinery. Nonetheless, its role appears to be context-dependent, and the detailed mechanism by which it governs the expression of most genes remains unknown. Here we investigate Mediator involvement in HSP (heat shock protein) gene regulation in the yeast Saccharomyces cerevisiae. We find that in response to thermal upshift, subunits representative of each of the four Mediator modules (Head, Middle, Tail, and Kinase) are rapidly, robustly, and selectively recruited to the promoter regions of HSP genes. Their residence is transient, returning to near-background levels within 90 min. Hsf1 (heat shock factor 1) plays a central role in recruiting Mediator, as indicated by the fact that truncation of either its N- or C-terminal activation domain significantly reduces Mediator occupancy, whereas removal of both activation domains abolishes it. Likewise, ablation of either of two Mediator Tail subunits, Med15 or Med16, reduces Mediator recruitment to HSP promoters, whereas deletion of both abolishes it. Accompanying the loss of Mediator, recruitment of RNA polymerase II is substantially diminished. Interestingly, Mediator antagonizes Hsf1 occupancy of non-induced promoters yet facilitates enhanced Hsf1 association with activated ones. Collectively, our observations indicate that Hsf1, via its dual activation domains, recruits holo-Mediator to HSP promoters in response to acute heat stress through cooperative physical and/or functional interactions with the Tail module. PMID:23447536

Conservation science in developing countries: an inside perspective on the struggles in sea turtle research and conservation in Venezuela

Energy Technology Data Exchange (ETDEWEB)

Buitrago, Joaquin [Estacion de Investigaciones Marinas de Margarita, Fundacion La Salle de Ciencias Naturales, Apartado 144, Porlamar, Isla Margarita (Venezuela)], E-mail: jbuitrago@edimar.org; Guada, Hedelvy J. [Centro de Investigacion y Conservacion de Tortugas Marinas CICTMAR, Red de Conservacion de Tortugas Marinas en el Gran Caribe, WIDECAST, Apdo. 50.789, Caracas 1050-A (Venezuela); Doyle, Emma [5 Woodvale Close, St. Ives, N.S.W. 2075 (Australia)

2008-10-15

Human exploitation of sea turtles in Venezuela dates back at least 800 years and continues to the present day. The first concerns about the status of sea turtle populations arose in the 1970s, and the projects from this early era were a tagging program, beach evaluation and in situ nest protection. Since then, efforts to develop a sea turtle research and conservation sector in Venezuela have resulted in a number of successes and rather more failures. Among the achievements is a course 'Sea Turtle Biology and Conservation Techniques', which has now been run for 15 years and has educated several hundred participants and enabled the establishment of a valuable professional network, and the publication of the Venezuelan 'Sea Turtle Recovery Action Plan' in 2000. But Venezuela shares with other developing countries some crucial shortcomings which have restricted the success of conservation and research efforts. Whilst regulations relating to protected areas and natural resource use have proliferated, enforcement is weak. Community-based projects and environmental education programs exist, but levels of participation are low. A large number of conservation approaches have been applied, including head-starting and nest translocation to hatcheries, but their value as conservation tools remains unproven. Research has increased, but its impact on decision-making is not significant. Taking an insider's perspective on the challenges to date in sea turtle research and conservation in Venezuela reveals much about the reality facing conservation scientists in developing countries and the forces that shape and can potentially derail research and conservation efforts.

Conservation science in developing countries: an inside perspective on the struggles in sea turtle research and conservation in Venezuela

International Nuclear Information System (INIS)

Buitrago, Joaquin; Guada, Hedelvy J.; Doyle, Emma

2008-01-01

Human exploitation of sea turtles in Venezuela dates back at least 800 years and continues to the present day. The first concerns about the status of sea turtle populations arose in the 1970s, and the projects from this early era were a tagging program, beach evaluation and in situ nest protection. Since then, efforts to develop a sea turtle research and conservation sector in Venezuela have resulted in a number of successes and rather more failures. Among the achievements is a course 'Sea Turtle Biology and Conservation Techniques', which has now been run for 15 years and has educated several hundred participants and enabled the establishment of a valuable professional network, and the publication of the Venezuelan 'Sea Turtle Recovery Action Plan' in 2000. But Venezuela shares with other developing countries some crucial shortcomings which have restricted the success of conservation and research efforts. Whilst regulations relating to protected areas and natural resource use have proliferated, enforcement is weak. Community-based projects and environmental education programs exist, but levels of participation are low. A large number of conservation approaches have been applied, including head-starting and nest translocation to hatcheries, but their value as conservation tools remains unproven. Research has increased, but its impact on decision-making is not significant. Taking an insider's perspective on the challenges to date in sea turtle research and conservation in Venezuela reveals much about the reality facing conservation scientists in developing countries and the forces that shape and can potentially derail research and conservation efforts

Combined heat and power in the City

Energy Technology Data Exchange (ETDEWEB)

Crafter, A. [Corporation of London (United Kingdom). Dept. of Technical Services

2002-03-01

This article reports on the development of a large-scale combined heat and power community energy scheme within the City of London. Supported by the Corporation of London and using its own buildings to provide the heating and cooling loads, the scheme has established a power plant close to Smithfield Meat Market and supplies district heating and chilled water for air conditioning to its own properties and some private customers in the nearby districts. Details are given of the power plant which is sited in a conservation area with limited access, the use of absorption chillers to produce the chilled water, the estimated amount of carbon dioxide emissions saved, and the financial benefits of the scheme.

Thermodynamic performance analysis and algorithm model of multi-pressure heat recovery steam generators (HRSG) based on heat exchangers layout

International Nuclear Information System (INIS)

Feng, Hongcui; Zhong, Wei; Wu, Yanling; Tong, Shuiguang

2014-01-01

Highlights: • A general model of multi-pressure HRSG based on heat exchangers layout is built. • The minimum temperature difference is introduced to replace pinch point analysis. • Effects of layout on dual pressure HRSG thermodynamic performances are analyzed. - Abstract: Changes of heat exchangers layout in heat recovery steam generator (HRSG) will modify the amount of waste heat recovered from flue gas; this brings forward a desire for the optimization of the design of HRSG. In this paper the model of multi-pressure HRSG is built, and an instance of a dual pressure HRSG under three different layouts of Taihu Boiler Co., Ltd. is discussed, with specified values of inlet temperature, mass flow rate, composition of flue gas and water/steam parameters as temperature, pressure etc., steam mass flow rate and heat efficiency of different heat exchangers layout of HRSG are analyzed. This analysis is based on the laws of thermodynamics and incorporated into the energy balance equations for the heat exchangers. In the conclusion, the results of the steam mass flow rate, heat efficiency obtained for three heat exchangers layout of HRSGs are compared. The results show that the optimization of heat exchangers layout of HRSGs has a great significance for waste heat recovery and energy conservation

49 CFR 179.200-11 - Postweld heat treatment.

Science.gov (United States)

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Postweld heat treatment. 179.200-11 Section 179.200-11 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... Postweld heat treatment. When specified in § 179.201-1, after welding is complete, postweld heat treatment...

Visible cost - invisible profit. The heating, ventilation and sanitary sector and the realization of energy conservation. Among politics, knowledge and practice; Synlig kostnad - skjult gevinst. VVS-bransjen og realisering av ENOEK. Mellom politikk, kunnskap og praksis

Energy Technology Data Exchange (ETDEWEB)

Hubak, Marit

1998-07-01

In social research, technology has customarily been considered problem-generating. What is needed to turn new technology into a positive instrument in environmental work? To answer this question one must understand the interaction between politics, knowledge and practice that is important for dealing with the environmental challenges. It is a main objective of this book to contribute to this understanding by analysing how the building industry deals with the energy and environmental challenges that are commonly known as energy conservation. Specifically, the book deals with the heating, ventilation and sanitary sector since this is where most of the companies working with energy conservation are found. The discussion applies to Norway0.

Near-term viability of solar heat applications for the federal sector

Science.gov (United States)

Williams, T. A.

1991-12-01

Solar thermal technologies are capable of providing heat across a wide range of temperatures, making them potentially attractive for meeting energy requirements for industrial process heat applications and institutional heating. The energy savings that could be realized by solar thermal heat are quite large, potentially several quads annually. Although technologies for delivering heat at temperatures above 100 C currently exist within industry, only a fairly small number of commercial systems have been installed to date. The objective of this paper is to investigate and discuss the prospects for near term solar heat sales to federal facilities as a mechanism for providing an early market niche to the aid the widespread development and implementation of the technology. The specific technical focus is on mid-temperature (100 to 350 C) heat demands that could be met with parabolic trough systems. Federal facilities have several features relative to private industry that may make them attractive for solar heat applications relative to other sectors. Key features are specific policy mandates for conserving energy, a long term planning horizon with well defined decision criteria, and prescribed economic return criteria for conservation and solar investments that are generally less stringent than the investment criteria used by private industry. Federal facilities also have specific difficulties in the sale of solar heat technologies that are different from those of other sectors, and strategies to mitigate these difficulties will be important. For the baseline scenario developed in this paper, the solar heat application was economically competitive with heat provided by natural gas. The system levelized energy cost was $5.9/MBtu for the solar heat case, compared to $6.8/MBtu for the life cycle fuel cost of a natural gas case. A third-party ownership would also be attractive to federal users, since it would guarantee energy savings and would not need initial federal funds.

PN solutions of radiative heat transfer in a slab with reflective boundaries

International Nuclear Information System (INIS)

Atalay, M.A.

2006-01-01

The spherical harmonics method is used to obtain solution for the radiative heat transfer equation for a slab with reflective boundaries. An absorbing, emitting, non-isothermal, gray medium is considered with linearly anisotropic scattering. Under the condition of the thermal equilibrium, the slab boundaries are subjected to specular and diffuse reflection. The analytical form of solutions is obtained for both conservative and non-conservative cases. The accuracy of the method was verified by benchmark comparisons against the solutions of an earlier work performed by the normal-mode expansion technique. The present predictions of heat flux were found to be in good agreement with the benchmark data. a

Consideration of heat transfer performance of helium-gas/water coolers in HENDEL

International Nuclear Information System (INIS)

Inagaki, Yoshiyuki; Miyamoto, Yoshiaki

1986-10-01

The helium engineering loop (HENDEL) has four helium-gas/water coolers, where the cooling water flows in the tubes and the helium gas flows on the shell side. Their cooling performance depends on mainly the heat transfer of helium gas on the shell side. This report describes the operational data of the coolers and the consideration of the heat transfer performance which is important for the design of coolers. It becomes clear that Donohue's equation is close to the operational data and conservative for the segmental baffle type cooler and preduction by Fishenden-Saunders or Zukauskas' equation is conservation for the step-up baffle type cooler. (author)

Assessment of the industrial energy-conservation program. Final report of the Committee on Assessment of the Industrial Energy Conservation Program

Energy Technology Data Exchange (ETDEWEB)

None

1982-01-01

Industrial operations in the United States account for some 37% of the nation's consumptions of energy. It has been estimated that this figure will increase to 50% by 1990 unless appropriate industrial energy conservation measures are adopted. However, such measures are difficult to implement in spite of the potential of various existing, emerging, and advanced technologies that can be applied to the problem. Specifically, the application of many industrial energy conservation measures entails high economic, technological, and institutional risks and uncertainties that constrain industries from adopting such measures. Accordingly, in 1975 the federal government started a program designed to mitigate these risks and uncertainties via government-industry partnership arrangements in the interests of national energy conservation. An important element of this program is the Industrial Energy Conservation Program in the Federal Department of Energy (DOE). In June 1980, DOE asked the National Materials Advisory Board, a unit of the National Academy of Sciences-National Research Council, to form a study committee to assess the effectiveness of the Industrial Energy Conservation Program. The committee concluded that federal support embodied in the DOE program, present and planned, is important to conserving additional industrial energy. However, the committee also concluded that the program needs various improvements in project selection and management and in transfer of results to industry. The committee's findings and recommendations and the results of the deliberation of the committee's three panels, a special report on heat and power, and a report on the visit by four members of the committee to Japan are presented.

Institutional stakeholders’ views on jaguar conservation issues in central Brazil

Directory of Open Access Journals (Sweden)

Yennie K. Bredin

2015-01-01

Full Text Available Large carnivore management is typically a source of heated controversy worldwide and, in the Americas, jaguars (Panthera onca are at the centre of many human–wildlife conflicts. Although findings suggest that social, rather than economic, factors are important reasons for why humans kill jaguars, few studies focus on stakeholder attitudes towards jaguar conservation beyond quantifying livestock depredation. Yet insights from other large carnivore conflicts demonstrate the importance of the political landscape and stakeholder attitudes in carnivore conservation. To explore the extent to which stakeholder views about jaguar conservation aligned with institutional arrangements, we conducted a stakeholder analysis among personnel working for key institutions in central Brazil. Using Q methodology, we identified three stakeholder perspectives focusing on: A jaguars’ intrinsic right to exist; B wider ecocentric values; and C contesting jaguar-focused conservation. The three institutional stakeholder groups all accepted the jaguar’s fundamental right to exist and agreed that it was important to establish protected areas for jaguars. Yet, institutional stakeholder views diverged regarding the desired distribution of jaguars in Brazil, hunting policies, and the effects of hunting and development projects on jaguar conservation. These differences and their underlying motivations are important to consider for successful jaguar conservation strategies in Brazil.

Study of condensation heat transfer following a main steam line break inside containment

Energy Technology Data Exchange (ETDEWEB)

Cho, J.H.; Elia, F.A. Jr.; Lischer, D.J. [Stone & Webster Engineering Corporation, Boston, MA (United States)

1995-09-01

An alternative model for calculating condensation heat transfer following a main stream line break (MSLB) accident is proposed. The proposed model predictions and the current regulatory model predictions are compared to the results of the Carolinas Virginia Tube Reactor (CVTR) test. The very conservative results predicted by the current regulatory model result from: (1) low estimate of the condensation heat transfer coefficient by the Uchida correlation and (2) neglecting the convective contribution to the overall heat transfer. Neglecting the convection overestimates the mass of steam being condensed and does not permit the calculation of additional convective heat transfer resulting from superheated conditions. In this study, the Uchida correlation is used, but correction factors for the effects of convection an superheat are derived. The proposed model uses heat and mass transfer analogy methods to estimate to convective fraction of the total heat transfer and bases the steam removal rate on the condensation heat transfer portion only. The results predicted by the proposed model are shown to be conservative and more accurate than those predicted by the current regulatory model when compared with the results of the CVTR test. Results for typical pressurized water reactors indicate that the proposed model provides a basis for lowering the equipment qualification temperature envelope, particularly at later times following the accident.

Barriers to the adoption of energy-conserving technologies in the textile industry

Energy Technology Data Exchange (ETDEWEB)

Evans, A.R.; Zussman, S.K.

1979-09-01

An overview of the textile industry and a discussion of energy-conserving technologies currently available at the pilot-demonstration stage are presented. Existing and potential barriers to the adoption of these technologies in the textile industry identified are: economic; technical acceptance; conflict between commitments of capital for compliance with environmental and health regulations and for investment in energy conservation measures; and a lack of information and technical expertise. Possible measures to eliminate barriers to the implementation of energy-conserving technologies are discussed. (MCW)

Sustainability of three modified soil conservation methods in agriculture area

Science.gov (United States)

Setiawan, M. A.; Sara, F. H.; Christanto, N.; Sartohadi, J.; Samodra, G.; Widicahyono, A.; Ardiana, N.; Widiyati, C. N.; Astuti, E. M.; Martha, G. K.; Malik, R. F.; Sambodo, A. P.; Rokhmaningtyas, R. P.; Swastanto, G. A.; Gomez, C.

2018-04-01

Recent innovations in soil conservation methods do not present any breakthrough. Providing more attractive soil conservation methods from the farmer’s perspective is however still of critical importance. Contributing to this soil research gap we attempt to evaluate the sustainable use of three modified conservation methods, namely JALAPA (Jala Sabut Kelapa - geotextile made of coconut fibres), wood sediment trap, and polybag system compared to traditional tillage without conservation method. This research provides both qualitative and quantitative analysis on the performance of each conservation measures. Therefore, in addition to the total sediment yield value and investment cost – as quantitative analysis, we also evaluate qualitatively the indicator of soil loss, installation, maintenance, and the durability of conservation medium. Those criteria define the sustainability use of each conservation method. The results show that JALAPA is the most effective method for controlling soil loss, but it also requires the most expensive cost for installation. However, our finding confirms that geotextile is sensitive to sun heating by which the coconut fibre can become dry and shrink. Wood sediment trap is the cheapest and easiest to install; however it is easily damaged by termite. Polybag method results in the highest productivity, but requires more time during the first installation. In terms of the farmer’s perspective, soil conservation using polybag system was the most accepted technique due to its high benefits; even if it is less effective at reducing soil loss compared to JALAPA.

Heat-resistant mechanism of transgenic rape by 45Ca isotope tracer

International Nuclear Information System (INIS)

Xu Falun; Yang Yuanyou; Liu Ning; Liao Jiali; Yang Jijun; Tang Jun; Liu Zhibin; Yang Yi

2012-01-01

The Ca 2+ uptake differences of the rape with heat-resistant gene and the general rape were investigated by 45 Ca isotope tracer. The results showed that the rape with heat-resistant gene can strengthen the regulation of calcium absorption. The calcium regulation ability of the heat-resistant genes may be able to play in the rape aspect of the mechanism of resistance. (authors)

Conserved structure and expression of hsp70 paralogs in teleost fishes

DEFF Research Database (Denmark)

Metzger, David C.H.; Hansen, Jakob Hemmer; Schulte, Patricia M.

2016-01-01

present in the F. heteroclitus genome. Comparison of expression patterns in F. heteroclitus and Gasterosteus aculeatus demonstrates that hsp70-2 has a higher fold increase than hsp70-1 following heat shock in gill but not in muscle tissue, revealing a conserved difference in expression patterns between...

Energy and Architecture: The Solar and Conservation Potential. Worldwatch Paper 40.

Science.gov (United States)

Flavin, Christopher

This monograph explores how architecture is influenced by and is responding to the global energy dilemma. Emphasis is placed on conservation techniques (using heavy insulation) and on passive solar construction (supplying most of a building's heating, cooling, and lighting requirements by sunlight). The basic problem is that architecture, like…

Electric heating of religious buildings; Chauffage des lieux de culte par l`electricite

Energy Technology Data Exchange (ETDEWEB)

Jicquel, J M; Collober, M; Veyrat, O [Electricite de France, 92 - Clamart (France). Direction des Etudes et Recherches

1997-06-01

This paper reports on in-situ measurements performed in churches which allow to retain interesting solutions for electric heating. Churches are characterized by an important thermal inertia, a huge volume, an intermittency of use (some few hours a week) and by thermal, physical and chemical constraints for the good preservation of works of art and general esthetics of the building, in particular in the case of listed historical monuments. The installation of heating systems in such monuments requires authorizations from the historical monuments, the sacred art and the safety commissions. This paper summarizes the regulations and recommendations concerning: the thermal insulation, the heating regulation and programming, the ventilation, the fire safety, the electrical installation and the lighting. Then, the available electric powered heating systems are reviewed and described in details (principle, dimension, regulation, domain of use, installation): radiant short-infrared emitters, heating moquettes and heating pews. The choice criteria for a given heating system are analyzed according to the different constraints of the building (size, architecture, regulations, comfort, consumption costs) and finally the advantages of electric power heating are listed (no combustion products, low temperature stratification, aesthetics, silence and service life). (J.S.)

29 CFR 1919.16 - Heat treatment.

Science.gov (United States)

2010-07-01

... 29 Labor 7 2010-07-01 2010-07-01 false Heat treatment. 1919.16 Section 1919.16 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) GEAR CERTIFICATION Certification of Vessels' Cargo Gear § 1919.16 Heat treatment. (a) All chains (other...

Energy R and D programme: energy conservation research. Survey of results (1975-1979) and compilation of selected new projects (1979-1983)

Energy Technology Data Exchange (ETDEWEB)

Zegers, P [ed.

1981-01-01

Results obtained in the European Communities Energy Conservation Research and Development (R and D) Program are presented. Energy Conservation R and D was executed in the following subsectors: improved insulation of buildings; use of heat pumps; urban transport; residual heat recovery; materials recycling; production of energy from waste; industrial processes; and storage of secondary energy. Summaries are presented for information gained from the research projects. Then, separate abstracts for all final reports (96), contract numbers, and the authors are given. (MCW)

Energy literacy, awareness, and conservation behavior of residential households

International Nuclear Information System (INIS)

Brounen, Dirk; Kok, Nils; Quigley, John M.

2013-01-01

The residential sector accounts for one-fifth of global energy consumption, resulting from the requirements to heat, cool, and light residential dwellings. It is therefore not surprising that energy efficiency in the residential market has gained importance in recent years. In this paper, we examine awareness, literacy and behavior of households with respect to their residential energy expenditures. Using a detailed survey of 1721 Dutch households, we measure the extent to which consumers are aware of their energy consumption and whether they have taken measures to reduce their energy costs. Our results show that “energy literacy” and awareness among respondents is low: just 56% of the respondents are aware of their monthly charges for energy consumption, and 40% do not appropriately evaluate investment decisions in energy efficient equipment. We document that demographics and consumer attitudes towards energy conservation, but not energy literacy and awareness, have direct effects on behavior regarding heating and cooling of the home. The impact of a moderating factor, measured by thermostat settings, ultimately results in strong variation in the energy consumption of private consumers. - Highlights: • We use a detailed survey of 1,721 Dutch households to measure awareness and conservation behavior in energy consumption. • Energy literacy and awareness among residential households is low. • 40 percent of the sample does not appropriately evaluate investment decisions in energy efficient equipment • Demographics and consumer attitudes affect behavior regarding heating and cooling of a home

Identification of let-7-regulated oncofetal genes

DEFF Research Database (Denmark)

Boyerinas, Benjamin; Park, Sun-Mi; Shomron, Noam

2008-01-01

-regulated at the end of embryonic development. Let-7 is often down-regulated early during cancer development, suggesting that let-7-regulated oncofetal genes (LOG) may become reexpressed in cancer cells. Using comparative bioinformatics, we have identified 12 conserved LOGs that include HMGA2 and IMP-1/CRD-BP. IMP-1...

78 FR 22036 - Proposed Collection; Comment Request for Regulation Project

Science.gov (United States)

2013-04-12

... fair market value of the underlying property before and after the donation and (2) the conservation... qualified conservation contributions (Sec. 1.170A-14). DATES: Written comments should be received on or... INFORMATION: Title: Qualified Conservation Contributions. OMB Number: 1545-0763. Regulation Project Number: TD...

Establishment of Passive Energy Conservation Measure and Economic Evaluation of Fenestration System in Nonresidential Building of Korea

Directory of Open Access Journals (Sweden)

Bo-Eun Choi

2017-01-01

Full Text Available ECO2 (building energy efficiency rating program and passive energy conservation measures (ECMs were established as a basic study for targeted methodologies and decision support systems development in Korea to meet national regulations. The primary energy consumption and economic evaluation of nonresidential buildings was performed. Passive ECMs were classified as planning and performance elements. The planning elements are the window-to-wall ratio (WWR and horizontal shading angle. The performance elements are the thermal transmittance (U-value of the walls, roof, and floor and the U-value and solar heat gain coefficient (SHGC of windows. This study focused on the window-to-wall ratio and the U-value and solar heat gain coefficient of windows. An economic efficiency database for the constructed alternatives was built; the target building was set and the Passive ECM List for the target building was derived. The energy consumption evaluation and economic evaluation were performed for each of the constructed alternatives, and a methodology for guiding energy efficiency decisions was proposed based on the performance evaluation results, and the optimal Passive ECM List for the target building was derived.

Influence of heat cost allocation on occupants' control of indoor environment in 56 apartments

DEFF Research Database (Denmark)

Andersen, Søren; Andersen, Rune Korsholm; Olesen, Bjarne W.

2016-01-01

-structured interviews showed a strong influence of the heat cost allocation plan on the occupants' control strategies. Occupants whose heating bills were based on floor area focused on a healthy and comfortable indoor environment. Occupants whose heating bills were based on meter readings focused on energy conservation...... of this paper was to study the indoor environment in buildings with collective and individual heat cost allocation plans, to investigate how the heat cost allocation influenced occupant behaviour and how occupants controlled the indoor environment. The effects of the heat cost allocation type were studied...

Prize-winning energy conservation house equipped with air collectors at Bad Vilbel

Energy Technology Data Exchange (ETDEWEB)

Urbanek, A.

An energy conservation house is the winner out of a total of 60 designs and is displayed at the prefabricated-house exhibition at Bad Vilbel. Similar to Socrates' building in antiquity, this house constitutes a triangle both perpendicularly and horizontally opening its largest possible surface to the South. Any 'residual heat' needed for the Northern roof planted over, is supplied by the air collectors either directly or by means of a high-performance heat pump via heating of the controlled feed air through a novel air floor heating installation while removing energy, too, from the exhaust air through heat recovery. In a survey supported by photos of models and buildings, lay-out plans and connector diagrams of energy supply, technical details of the heat protection concept (aerated concrete for walls, ceilings, roofing structures) and the energy concept with air collectors are described along with a discussion of heat pump operation, the novel air floor heating system and the solar cycle control system. Every room has a miniature heat exchanger allocated in the central unit so that re-heated air can be demanded via the separate room thermostat depending on reflow-air temperature.

Second Law Analysis in Convective Heat and Mass Transfer

Directory of Open Access Journals (Sweden)

A. Ben Brahim

2006-02-01

Full Text Available This paper reports the numerical determination of the entropy generation due to heat transfer, mass transfer and fluid friction in steady state for laminar double diffusive convection, in an inclined enclosure with heat and mass diffusive walls, by solving numerically the mass, momentum, species conservation and energy balance equations, using a Control Volume Finite-Element Method. The influences of the inclination angle, the thermal Grashof number and the buoyancy ratio on total entropy generation were investigated. The irreversibilities localization due to heat transfer, mass transfer and fluid friction is discussed for three inclination angles at a fixed thermal Grashof number.

The potential demand for bioenergy in residential heating applications (bio-heat) in the UK based on a market segment analysis

International Nuclear Information System (INIS)

Jablonski, S.; Pantaleo, A.; Bauen, A.; Pearson, P.; Panoutsou, C.; Slade, R.

2008-01-01

How large is the potential demand for bio-heat in the UK? Whilst most research has focused on the supply of biomass for energy production, an understanding of the potential demand is crucial to the uptake of heat from bioenergy. We have designed a systematic framework utilising market segmentation techniques to assess the potential demand for biomass heat in the UK. First, the heat market is divided into relevant segments, characterised in terms of their final energy consumption, technological and fuel supply options. Second, the key technical, economic and organisational factors that affect the uptake of bioenergy in each heat segment are identified, classified and then analysed to reveal which could be strong barriers, which could be surmounted easily, and for which bioenergy heat represents an improvement compared to alternatives. The defined framework is applied to the UK residential sector. We identify provisionally the most promising market segments for bioenergy heat, and their current levels of energy demand. We find that, depending on the assumptions, the present potential demand for bio-heat in the UK residential sector ranges between 3% (conservative estimate) and 31% (optimistic estimate) of the total energy consumed in the heat market. (author)

Design and functionality of a segmented heat-storage prototype utilizing stable supercooling of sodium acetate trihydrate in a solar heating system

DEFF Research Database (Denmark)

Englmair, Gerald; Moser, Christoph; Furbo, Simon

2018-01-01

acetate trihydrate composites to conserve the latent heat of fusion for long-term heat storage. A control strategy directed heat from a solar collector array to either the PCM storage or a water buffer storage. Several PCM units had to be charged in parallel when the solar collector output peaked at 16 k......A solar heating system with 22.4m2 of solar collectors, a heat storage prototype consisting of four 200 kg phase-change material (PCM) storage units, and a 735 L water tank was designed to improve solar heat supply in single-family houses. The PCM storage utilized stable supercooling of sodium......W. A single unit was charged with 27.4 kWh of heat within four hours on a sunny day, and the PCM temperature increased from 20 °C to 80 °C. The sensible heat from a single PCM unit was transferred to the water tank starting with about 32 kW of thermal power after it had fully melted at 80 °C. A mechanical...

Efficiency gains in Danish district heating. Is there anything to learn from benchmarking?

DEFF Research Database (Denmark)

Munksgaard, Jesper; Pade, Lise-Lotte; Fristrup, P.

2005-01-01

Facing a market structure of independent heating systems and cost-of-service regulation the regulator considers ways to create incentives for increasing efficiency in heat production.One way is to implement benchmark regulation. The aim of this paper is twofold: (1) To investigate the potential f...

Energy audit and conservation opportunities for pyroprocessing unit of a typical dry process cement plant

International Nuclear Information System (INIS)

Kabir, G.; Abubakar, A.I.; El-Nafaty, U.A.

2010-01-01

Cement production process has been highly energy and cost intensive. The cement plant requires 8784 h per year of the total operating hours to produce 640,809 tonnes of clinker. To achieve effective and efficient energy management scheme, thermal energy audit analysis was employed on the pyroprocessing unit of the cement plant. Fuel combustion generates the bulk of the thermal energy for the process, amounting to 95.48% (4164.02 kJ/kg cl ) of the total thermal energy input. Thermal efficiency of the unit stands at 41%, below 50-54% achieved in modern plants. The exhaust gases and kiln shell heat energy losses are in significant quantity, amounting to 27.9% and 11.97% of the total heat input respectively. To enhance the energy performance of the unit, heat losses conservation systems are considered. Waste heat recovery steam generator (WHRSG) and Secondary kiln shell were studied. Power and thermal energy savings of 42.88 MWh/year and 5.30 MW can be achieved respectively. Financial benefits for use of the conservation methods are substantial. Environmental benefit of 14.10% reduction in Greenhouse gases (GHG) emissions could be achieved.

Energy audit and conservation opportunities for pyroprocessing unit of a typical dry process cement plant

Energy Technology Data Exchange (ETDEWEB)

Kabir, G.; Abubakar, A.I.; El-Nafaty, U.A. [Chemical Engineering Programme, Abubakar Tafawa Balewa University, P. M. B. 0248, Bauchi (Nigeria)

2010-03-15

Cement production process has been highly energy and cost intensive. The cement plant requires 8784 h per year of the total operating hours to produce 640,809 tonnes of clinker. To achieve effective and efficient energy management scheme, thermal energy audit analysis was employed on the pyroprocessing unit of the cement plant. Fuel combustion generates the bulk of the thermal energy for the process, amounting to 95.48% (4164.02 kJ/kg{sub cl}) of the total thermal energy input. Thermal efficiency of the unit stands at 41%, below 50-54% achieved in modern plants. The exhaust gases and kiln shell heat energy losses are in significant quantity, amounting to 27.9% and 11.97% of the total heat input respectively. To enhance the energy performance of the unit, heat losses conservation systems are considered. Waste heat recovery steam generator (WHRSG) and Secondary kiln shell were studied. Power and thermal energy savings of 42.88 MWh/year and 5.30 MW can be achieved respectively. Financial benefits for use of the conservation methods are substantial. Environmental benefit of 14.10% reduction in Greenhouse gases (GHG) emissions could be achieved. (author)

TRPA1 channels in Drosophila and honey bee ectoparasitic mites share heat sensitivity and temperature-related physiological functions

Directory of Open Access Journals (Sweden)

Guangda Peng

2016-10-01

Full Text Available The transient receptor potential cation channel, subfamily A, member 1 (TRPA1 is conserved between many arthropods, and in some has been shown to function as a chemosensor for noxious compounds. Activation of arthropod TRPA1 channels by temperature fluctuations has been tested in only a few insect species, and all of them were shown to be activated by heat. The recent identification of chemosensitive TRPA1 channels from two honey bee ectoparasitic mite species (VdTRPA1 and TmTRPA1 have provided an opportunity to study the temperature-dependent activation and the temperature-associated physiological functions of TRPA1 channels in non-insect arthropods. We found that both mite TRPA1 channels are heat sensitive and capable of rescuing the temperature-related behavioral defects of a Drosophila melanogaster trpA1 mutant. These results suggest that heat-sensitivity of TRPA1 could be conserved between many arthropods despite its amino acid sequence diversity. Nevertheless, the ankyrin repeats (ARs 6 and 7 are well-conserved between six heat-sensitive arthropod TRPA1 channels and have critical roles for the heat activation of VdTRPA1.

Research and demonstration facilities for energy conservation and solar heating in the home

Science.gov (United States)

Newman, J. O.; Godbey, L. C.; Davis, M. A.; Ezell, D. O.; Allen, W. H.

1981-10-01

The design, testing and evaluation of two prototype solar holes are discussed. The first prototype is a greenhouse-residence designed with 6-in. wall cavities (to increase insulation thickness), a 381 sq. ft. solar collector used primarily for space heating, and a greenhouse that was utilized as a solar collector for growing vegetables. The house does feature a domestic hot water preheating system and an electrical resistance back-up heating system. The second prototype is an earth-insulated house designed primarily to study the physical features of the house in relation to the soil around it and the thermal interaction between the soil and the house environment. This house features a high temperature air collector that is used for domestic water heating. A special effort was made to have adequate daylight in the solar-earth house. A special study was conducted on the geometric configuration of the rock storage and the methods of admitting air to the rock storage.

Heat Coulomb blockade of one ballistic channel

Science.gov (United States)

Sivre, E.; Anthore, A.; Parmentier, F. D.; Cavanna, A.; Gennser, U.; Ouerghi, A.; Jin, Y.; Pierre, F.

2018-02-01

Quantum mechanics and Coulomb interaction dictate the behaviour of small circuits. The thermal implications cover fundamental topics from quantum control of heat to quantum thermodynamics, with prospects of novel thermal machines and an ineluctably growing influence on nanocircuit engineering. Experimentally, the rare observations thus far include the universal thermal conductance quantum and heat interferometry. However, evidence for many-body thermal effects paving the way to markedly different heat and electrical behaviours in quantum circuits remains wanting. Here we report on the observation of the Coulomb blockade of electronic heat flow from a small metallic circuit node, beyond the widespread Wiedemann-Franz law paradigm. We demonstrate this thermal many-body phenomenon for perfect (ballistic) conduction channels to the node, where it amounts to the universal suppression of precisely one quantum of conductance for the transport of heat, but none for electricity. The inter-channel correlations that give rise to such selective heat current reduction emerge from local charge conservation, in the floating node over the full thermal frequency range (laws for thermal transport in nanocircuits.

Advanced Supermarket Refrigeration/Heat Recovery Systems. Country Report, Denmark

DEFF Research Database (Denmark)

Knudsen, Hans-Jørgen Høgaard; Christensen, K. G.

Annex 26 is the first international project under the IEA Heat Pump Programme that links refrigeration and heat pump technology. Recovering heat from advanced supermarket refrigeration systems for space and water heating seems obvious and is beneficial for owners and operators. Because the great...... number of supermarkets that offer frozen and chilled food and further growth of this sector may be expected, the amount of energy used for refrigeration is enormous and will likely increase in the near future. Annex 26 analysed several advanced supermarket refrigeration systems and came to remarkable...... conclusions as far energy conservation and TEWI reduction is concerned. The conclusion justify that advanced supermarket systems with heat recovery should receive great attention and support. And there is still further research needed in several areas. The Annex also included a thorough system analyses...

Heating and dehumidification in production greenhouses at northern latitudes

NARCIS (Netherlands)

Kempkes, F.; Zwart, De H.F.; Munoz, P.; Montero, J.I.; Baptista, F.J.; Giuffrida, F.; Gilli, Celine; Stepowska, Agnieszka; Stanghellini, C.

2017-01-01

The majority of greenhouses in northern latitudes are heated, in the winter mainly for temperature control and year round to control humidity. Heating is accepted by most organic regulations in different countries; if heating efficiently and the energy source is predominantly renewable energy,

Scheduling of radio-controlled heating load

International Nuclear Information System (INIS)

Fox, B.; McCartney, A.I.; McCann, B.M.

1998-01-01

An economic loading program has been adapted to enable it to obtain an optimum heat-load profile to meet the forecast heat requirement. The heat load is represented by a 'generator' whose load is constrained to be negative. The incremental cost of this unit is a heat energy price. This is adjusted to obtain a heat profile containing the requisite energy. The profile is then used by a dynamic programming algorithm to derive a commitment pattern for each block. A case study is presented which shows that the procedure can minimise heat energy cost. It is also shown that use of the proposed method results in less generator load cycling. This reduced regulation duty should improve reliability. (author)

Genetic and epigenetic control of plant heat responses

Directory of Open Access Journals (Sweden)

Junzhong eLiu

2015-04-01

Full Text Available Plants have evolved sophisticated genetic and epigenetic regulatory systems to respond quickly to unfavorable environmental conditions such as heat, cold, drought, and pathogen infections. In particular, heat greatly affects plant growth and development, immunity and circadian rhythm, and poses a serious threat to the global food supply. According to temperatures exposing, heat can be usually classified as warm ambient temperature (about 22-27℃, high temperature (27-30℃ and extremely high temperature (37-42℃, also known as heat stress for the model plant Arabidopsis thaliana. The genetic mechanisms of plant responses to heat have been well studied, mainly focusing on elevated ambient temperature-mediated morphological acclimation and acceleration of flowering, modulation of plant immunity and circadian clock by high temperatures, and thermotolerance to heat stress. Recently, great progress has been achieved on epigenetic regulation of heat responses, including DNA methylation, histone modifications, histone variants, ATP-dependent chromatin remodeling, histone chaperones, small RNAs, long non-coding RNAs and other undefined epigenetic mechanisms. These epigenetic modifications regulate the expression of heat-responsive genes and function to prevent heat-related damage. This review focuses on recent progresses regarding the genetic and epigenetic control of heat responses in plants, and pays more attention to the role of the major epigenetic mechanisms in plant heat responses. Further research perspectives are also discussed.

Profit by conserving energy in your restaurant. Economies d'energie et profits a la carte

Energy Technology Data Exchange (ETDEWEB)

1981-01-01

This manual is aimed at the Canadian restaurant sector with a view of promoting sound energy conservation practices. Monitoring is recommended to identify energy consumption and measure results of a conservation effects. These efforts can be done with respect to selection, operation, and maintenance of restaurant equipment used in food preparation, HVAC systems, refrigeration, water heating, and lighting. Overall building design and planning of new installations are also considered. 27 figs.

A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.

Directory of Open Access Journals (Sweden)

Joshua Wollam

Full Text Available Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel means to influence health and life span. In C. elegans, bile acid-like steroids called the dafachronic acids (DAs regulate developmental timing and longevity through the conserved nuclear hormone receptor DAF-12, a homolog of mammalian sterol-regulated receptors LXR and FXR. Using metabolic genetics, mass spectrometry, and biochemical approaches, we identify new activities in DA biosynthesis and characterize an evolutionarily conserved short chain dehydrogenase, DHS-16, as a novel 3-hydroxysteroid dehydrogenase. Through regulation of DA production, DHS-16 controls DAF-12 activity governing longevity in response to signals from the gonad. Our elucidation of C. elegans bile acid biosynthetic pathways reveals the possibility of novel ligands as well as striking biochemical conservation to other animals, which could illuminate new targets for manipulating longevity in metazoans.

Thermal control system. [removing waste heat from industrial process spacecraft

Science.gov (United States)

Hewitt, D. R. (Inventor)

1983-01-01

The temperature of an exothermic process plant carried aboard an Earth orbiting spacecraft is regulated using a number of curved radiator panels accurately positioned in a circular arrangement to form an open receptacle. A module containing the process is insertable into the receptacle. Heat exchangers having broad exterior surfaces extending axially above the circumference of the module fit within arcuate spacings between adjacent radiator panels. Banks of variable conductance heat pipes partially embedded within and thermally coupled to the radiator panels extend across the spacings and are thermally coupled to broad exterior surfaces of the heat exchangers by flanges. Temperature sensors monitor the temperature of process fluid flowing from the module through the heat exchanges. Thermal conduction between the heat exchangers and the radiator panels is regulated by heating a control fluid within the heat pipes to vary the effective thermal length of the heat pipes in inverse proportion to changes in the temperature of the process fluid.

Highly conserved non-coding sequences are associated with vertebrate development.

Directory of Open Access Journals (Sweden)

Adam Woolfe

2005-01-01

Full Text Available In addition to protein coding sequence, the human genome contains a significant amount of regulatory DNA, the identification of which is proving somewhat recalcitrant to both in silico and functional methods. An approach that has been used with some success is comparative sequence analysis, whereby equivalent genomic regions from different organisms are compared in order to identify both similarities and differences. In general, similarities in sequence between highly divergent organisms imply functional constraint. We have used a whole-genome comparison between humans and the pufferfish, Fugu rubripes, to identify nearly 1,400 highly conserved non-coding sequences. Given the evolutionary divergence between these species, it is likely that these sequences are found in, and furthermore are essential to, all vertebrates. Most, and possibly all, of these sequences are located in and around genes that act as developmental regulators. Some of these sequences are over 90% identical across more than 500 bases, being more highly conserved than coding sequence between these two species. Despite this, we cannot find any similar sequences in invertebrate genomes. In order to begin to functionally test this set of sequences, we have used a rapid in vivo assay system using zebrafish embryos that allows tissue-specific enhancer activity to be identified. Functional data is presented for highly conserved non-coding sequences associated with four unrelated developmental regulators (SOX21, PAX6, HLXB9, and SHH, in order to demonstrate the suitability of this screen to a wide range of genes and expression patterns. Of 25 sequence elements tested around these four genes, 23 show significant enhancer activity in one or more tissues. We have identified a set of non-coding sequences that are highly conserved throughout vertebrates. They are found in clusters across the human genome, principally around genes that are implicated in the regulation of development

Discovery of cis-elements between sorghum and rice using co-expression and evolutionary conservation

Directory of Open Access Journals (Sweden)

Haberer Georg

2009-06-01

Full Text Available Abstract Background The spatiotemporal regulation of gene expression largely depends on the presence and absence of cis-regulatory sites in the promoter. In the economically highly important grass family, our knowledge of transcription factor binding sites and transcriptional networks is still very limited. With the completion of the sorghum genome and the available rice genome sequence, comparative promoter analyses now allow genome-scale detection of conserved cis-elements. Results In this study, we identified thousands of phylogenetic footprints conserved between orthologous rice and sorghum upstream regions that are supported by co-expression information derived from three different rice expression data sets. In a complementary approach, cis-motifs were discovered by their highly conserved co-occurrence in syntenic promoter pairs. Sequence conservation and matches to known plant motifs support our findings. Expression similarities of gene pairs positively correlate with the number of motifs that are shared by gene pairs and corroborate the importance of similar promoter architectures for concerted regulation. This strongly suggests that these motifs function in the regulation of transcript levels in rice and, presumably also in sorghum. Conclusion Our work provides the first large-scale collection of cis-elements for rice and sorghum and can serve as a paradigm for cis-element analysis through comparative genomics in grasses in general.

Effects of Governance on Availability of Land for Agriculture and Conservation in Brazil.

Science.gov (United States)

Sparovek, Gerd; Barretto, Alberto Giaroli de Oliveira Pereira; Matsumoto, Marcelo; Berndes, Göran

2015-09-01

The 2012 revision of the Brazilian Forest Act changed the relative importance of private and public governance for nature conservation and agricultural production. We present a spatially explicit land-use model for Brazilian agricultural production and nature conservation that considers the spatial distribution of agricultural land suitability, technological and management options, legal command, and control frameworks including the Atlantic Forest Law, the revised Forest Act, and the Amazonian land-titling, "Terra Legal," and also market-driven land use regulations. The model is used to analyze land use allocation under three scenarios with varying priorities among agricultural production and environmental protection objectives. In all scenarios, the legal command and control frameworks were the most important determinants of conservation outcomes, protecting at least 80% of the existing natural vegetation. Situations where such frameworks are not expected to be effective can be identified and targeted for additional conservation (beyond legal requirements) through voluntary actions or self-regulation in response to markets. All scenarios allow for a substantial increase in crop production, using an area 1.5-2.7 times the current cropland area, with much of new cropland occurring on current pastureland. Current public arrangements that promote conservation can, in conjunction with voluntary schemes on private lands where conversion to agriculture is favored, provide important additional nature conservation without conflicting with national agricultural production objectives.

Stretched flow of Oldroyd-B fluid with Cattaneo-Christov heat flux

Directory of Open Access Journals (Sweden)

T. Hayat

Full Text Available The objective of present attempt is to analyse the flow and heat transfer in the flow of an Oldroyd-B fluid over a non-linear stretching sheet having variable thickness. Characteristics of heat transfer are analyzed with temperature dependent thermal conductivity and heat source/sink. Cattaneo-Christov heat flux model is considered rather than Fourier’s law of heat conduction in the present flow analysis. Thermal conductivity varies with temperature. Resulting partial differential equations through laws of conservation of mass, linear momentum and energy are converted into ordinary differential equations by suitable transformations. Convergent series solutions for the velocity and temperature distributions are developed and discussed. Keywords: Oldroyd-B fluid, Variable sheet thickness, Cattaneo-Christov heat flux model, Heat source/sink, Temperature dependent thermal conductivity

CO2 reduction through energy conservation

International Nuclear Information System (INIS)

1991-05-01

A study was carried out of the potential to economically reduce carbon dioxide emissions through energy conservation in the petroleum and natural gas industry. The study examined current and projected emissions levels, cogeneration at gas plants, flaring, economics, regulation, reporting requirements, implementation, and research and development. Economically attractive energy conservation measures can reduce oil and gas industry, exclusive of Athabasca oil sands operations, CO 2 emissions by 6-7%. The energy conservation options identified range from field energy awareness committees through to equipment retrofits and replacement. At ca 3 million tonnes/y, these reductions will not offset the increases in oil and gas related CO 2 emissions anticipated by producers and Alberta government agencies. There will be increasing emphasis on in-situ bitumen production, more energy intensive light crude oil production and increasing natural gas sales, increasing energy inputs in excess of reductions. Cogeneration of electricity for utility company distribution and for internally required steam at gas plants and in-situ production sites is not economic due to low electricity prices. 8 tabs

Modeling the Performance of Water-Zeolite 13X Adsorption Heat Pump

Science.gov (United States)

Kowalska, Kinga; Ambrożek, Bogdan

2017-12-01

The dynamic performance of cylindrical double-tube adsorption heat pump is numerically analysed using a non-equilibrium model, which takes into account both heat and mass transfer processes. The model includes conservation equations for: heat transfer in heating/cooling fluids, heat transfer in the metal tube, and heat and mass transfer in the adsorbent. The mathematical model is numerically solved using the method of lines. Numerical simulations are performed for the system water-zeolite 13X, chosen as the working pair. The effect of the evaporator and condenser temperatures on the adsorption and desorption kinetics is examined. The results of the numerical investigation show that both of these parameters have a significant effect on the adsorption heat pump performance. Based on computer simulation results, the values of the coefficients of performance for heating and cooling are calculated. The results show that adsorption heat pumps have relatively low efficiency compared to other heat pumps. The value of the coefficient of performance for heating is higher than for cooling

MicroRNA160 Modulates Plant Development and Heat Shock Protein Gene Expression to Mediate Heat Tolerance in Arabidopsis

Directory of Open Access Journals (Sweden)

Jeng-Shane Lin

2018-02-01

Full Text Available Global warming is causing a negative impact on plant growth and adversely impacts on crop yield. MicroRNAs (miRNAs are critical in regulating the expression of genes involved in plant development as well as defense responses. The effects of miRNAs on heat-stressed Arabidopsis warrants further investigation. Heat stress increased the expression of miR160 and its precursors but considerably reduced that of its targets, ARF10, ARF16, and ARF17. To study the roles of miR160 during heat stress, transgenic Arabidopsis plants overexpressing miR160 precursor a (160OE and artificial miR160 (MIM160, which mimics an inhibitor of miR160, were created. T-DNA insertion mutants of miR160 targets were also used to examine their tolerances to heat stress. Results presented that overexpressing miR160 improved seed germination and seedling survival under heat stress. The lengths of hypocotyl elongation and rachis were also longer in 160OE than the wild-type (WT plants under heat stress. Interestingly, MIM160 plants showed worse adaption to heat. In addition, arf10, arf16, and arf17 mutants presented similar phenotypes to 160OE under heat stress to advance abilities of thermotolerance. Moreover, transcriptome and qRT-PCR analyses revealed that HSP17.6A, HSP17.6II, HSP21, and HSP70B expression levels were regulated by heat in 160OE, MIM160, arf10, arf16, and arf17 plants. Hence, miR160 altered the expression of the heat shock proteins and plant development to allow plants to survive heat stress.

Enhancing forest tenure reforms through more responsive regulations

Directory of Open Access Journals (Sweden)

Anne M Larson

2012-01-01

Full Text Available Forest tenure reforms have offered new opportunities for communities to obtain formal rights to forests and forest benefits, but at the same time a variety of limitations are placed on livelihood options. This article draws on several case studies of reforms in Africa, Asia and Latin America to analyse the regulations accompanying reforms. It identifies three types of regulations, namely rules that limit areas available to local communities; rules that delineate conservation areas and impose related limits on use; and bureaucratic requirements for permits and management plans, which restrict the commercial use and marketing of valuable forest products. It discusses problems with these regulations, and proposes a simple framework for identifying ways to promote regulations that work for forest conservation but are more responsive to the needs of communities and forests.

High qualitative and quantitative conservation of alternative splicing in Caenorhabditis elegans and Caenorhabditis briggsae

DEFF Research Database (Denmark)

Rukov, Jakob Lewin; Irimia, Manuel; Mørk, Søren

2007-01-01

Alternative splicing (AS) is an important contributor to proteome diversity and is regarded as an explanatory factor for the relatively low number of human genes compared with less complex animals. To assess the evolutionary conservation of AS and its developmental regulation, we have investigated...... the qualitative and quantitative expression of 21 orthologous alternative splice events through the development of 2 nematode species separated by 85-110 Myr of evolutionary time. We demonstrate that most of these alternative splice events present in Caenorhabditis elegans are conserved in Caenorhabditis briggsae....... Moreover, we find that relative isoform expression levels vary significantly during development for 78% of the AS events and that this quantitative variation is highly conserved between the 2 species. Our results suggest that AS is generally tightly regulated through development and that the regulatory...

Effect of mineral matter on coal self-heating rate

Energy Technology Data Exchange (ETDEWEB)

B. Basil Beamish; Ahmet Arisoy [University of Queensland, Brisbane, Qld. (Australia). School of Engineering

2008-01-15

Adiabatic self-heating tests have been conducted on subbituminous coal cores from the same seam profile, which cover a mineral matter content range of 11.2-71.1%. In all cases the heat release rate does not conform to an Arrhenius kinetic model, but can best be described by a third order polynomial. Assessment of the theoretical heat sink effect of the mineral matter in each of the tests reveals that the coal is less reactive than predicted using a simple energy conservation equation. There is an additional effect of the mineral matter in these cases that cannot be explained by heat sink alone. The disseminated mineral matter in the coal is therefore inhibiting the oxidation reaction due to physicochemical effects. 14 refs., 5 figs., 5 tabs.

Long-duration conservation of a nuclear power plant unit under construction

International Nuclear Information System (INIS)

Brun, C.; Long, A.; Saurin, P.; Liquette, A.

1994-01-01

The experience described is that of the Chooz B1 NPP unit, which had to be put into a state of conservation for one and one-half years with the reactor coolant system and auxiliary systems having been completely erected and internally cleaned. Erection of the secondary systems had been 80% completed. The dry conservation technique was adopted for all of the fluid systems and components, except for the injection and leakoff lines of the four reactor coolant pump no. 1 seals, for which wet conservation was employed. For the buildings themselves, Electricite de France (EdF) took measures to facilitate conservation, including ventilation and heating, limiting the entry of atmospheric air, and evacuating the dehumidifier regeneration air to the atmosphere via a collector and a fan. This conservation required the installation of 20 dry air generators, which enabled continuously circulating dry air through the systems and components. Monthly or bimonthly relative humidity checks, depending on the systems, were carried out. The results of these checks showed that the relative humidity remained below 50% throughout the NPP unit conservation period. For the steam generators, in addition to dry air circulation, humidity detectors as well as corrosion test coupons were installed on the tube sheet. (authors). 5 figs

Feasibility improvement project of a district heat supply system in Dalian, China

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

Investigations and discussions have been given on energy saving possibilities at two medium-sized heat and power supplying plants in the city of Dalian in China. The project will improve the operation methods of the heat and power plants so that the energy cost can be minimized, and attempt to improve the boiler heat efficiency and save the energy by means of heat recovery and utilization. The draft modification plan for energy conservation has planned operation optimization for energy conservation, control of boiler operation under variable pressure, modification of the external boiler heat converter, use of inverters for the large capacity motors for boilers, and recovery of heat from the boiler blow-down water. In the analysis, models were structured from the operation data, and the effects of applying the energy saving measures were derived from simulation. As a result, the energy saving effect was found to be about 13,000 tons at the Chunhai plant and about 7,000 tons at the Pulandian plant annually (converted to oil). The reduction in greenhouse gas emission was found to be about 40,000 tons at the Chunhai plant and about 20,000 tons at the Pulandian plant annually. The number of years for investment payback is about 4.1 years at the Chunhai plant, and about 4.9 years at the Pulandian plant, wherein good profitability can be estimated. (NEDO)

Underground storage of heat

International Nuclear Information System (INIS)

Despois, J.; Nougarede, F.

1976-01-01

The interest laying in heat storage is envisaged taking account of the new energy context, with a view to optimizing the use of production means of heat sources hardly modulated according to the demand. In such a way, a natural medium, without any constructions cost but only an access cost is to be used. So, porous and permeable rocky strata allowing the use of a pressurized water flow as a transfer fluid are well convenient. With such a choice high temperatures (200 deg C) may be obtained, that are suitable for long transmissions. A mathematical model intended for solving the conservation equations in the case of heat storage inside a confined water layer is discussed. An approach of the operating conditions of storage may involve either a line-up arrangement (with the hot drilling at the center, the cold drillings being aligned on both sides) or a radial arrangement (with cold drillings at the peripheral edge encircling the hot drilling at the center of the layer). The three principal problems encountered are: starting drilling, and the circuit insulation and control [fr

Principles of the Energy Conservation Bill

International Nuclear Information System (INIS)

Zeman, J.

1995-01-01

The paper describes 21 principles of the draft Energy Conservation Bill. The principles lay down fundamental responsibilities of the government, the municipalities, business entities, citizens and power plants in the field of economical energy management. Included are principles to minimize energy consumption and to stimulate a reasonable energy management, the role of the energy distribution network, responsibilities of the central load dispatching center, and power plant output regulation schemes. (J.B.)

Heat networks in France in 2014. Heat networks: which price for the consumer?

International Nuclear Information System (INIS)

Reynaud, Didier; Gong, Zheng; Moreau, Sylvain; Bottin, Anne; Reperant, Patricia

2016-04-01

A first document publishes and comments various statistics regarding heat networks in France in 2014: distribution in terms of quantity of supplied heat, main urban units, distribution in terms of urban unit size and in terms of community type (land, isolated town, outskirts, centre town). It also indicates the types, percentages and evolution of energies consumed in these heat networks, the shares of fossil and renewable energies, and the distribution of networks in terms of energy type. Some regional data are briefly commented (energy shares in each region, number of primary housing connected to an urban heating network). This publication also indicates methodological aspects and the definitions of the main components and characteristics of a heat network. Notably based on some of these data, the second document comments the price of heat supplied in these heat networks in 2014 as these prices are not regulated and depend on agreements between clients and providers. These prices are analysed in terms of linear thermal density, of heat quantity supplied by delivery point, of sector (industry, housing, office building), of rate of renewable energy, and of operator status (public service delegation or private ownership)

German Energiewende and the heating market – Impact and limits of policy

International Nuclear Information System (INIS)

Bauermann, Klaas

2016-01-01

The German Energiewende envisages achieving a climate-neutral building stock in 2050 by means of two major pillars of regulation. First, residential buildings should consume 80% less primary energy and second; the remaining energy demand should be covered primarily with renewables. This paper simulates the future German heating market under different policy scenarios in order to evaluate the impact and limits of recent and conceivable policies. The investigation is based upon a dual model approach, linking a residential heating model to a discrete choice model. The major finding is that current regulations are not suitable for the achievement of governmental targets. Scenario calculations show that additional carbon emission reductions, triggered by the current regulatory regime, are falling short of expectations. In terms of economic efficiency, all calculated policy alternatives outperform the regulation currently in place. This allows to draw the conclusion that carbon emission reductions can be achieved without a major increase in cost. The model results highlight two policy implications. First, a rising mandatory share of renewables in the heating market is needed for target achievement and can be cost effectively. Second, renewable obligations for heating systems must include the existing building stock to achieve the postulated political targets. - Highlights: •The residential heating market accounts for major share of carbon emissions. •The disregard of the building stock weakens the impact of recent regulation. •Current regulation preserves a heating market dominated by fossil fuels. •A significant renewable share can be achieved through direct regulation. •Alternative policy leads to emission reductions without major increases in costs.

Feasibility study on rehabilitation and improvement of thermal power plants, district heating and heat supply system in Botosani City

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

Discussions have been given on the improvement and modification project intended of saving energies and reducing greenhouse gas emission in the Botosani district heating and heat supplying facilities in Romania. Thirty years have elapsed since the building of the Botosani district heating and heat supplying facilities, whereas noticeable energy loss has occurred due to aged deterioration, such as thermal efficiency decrease, performance decrease, and hot water leakage due to piping corrosion. The present project is intended to improve the heat production and power generation facility efficiencies, and reduce the heat loss in heat transportation and distribution to less than 5%. The improvements will be implemented by replacing and rehabilitating the existing boilers, replacing the turbine generators, and replacing the transportation and distribution pipelines and heat exchangers. As a result of the discussions, the present project is estimated to result in annual fuel conservation of 35,820 tons of crude oil equivalent, and annual reduction of the greenhouse gas emission of 110,835 t-CO2. The total amount of the initial investment for the project would be 11.369 billion yen, and the payback period would be 12 years. The project will produce profit of 31.358 billion yen in 20 years, thus the project is financially feasible. (NEDO)

77 FR 12830 - Pershing County Water Conservation District; Notice of Intent To File License Application, Filing...

Science.gov (United States)

2012-03-02

... Water Conservation District; Notice of Intent To File License Application, Filing of Pre-Application.... Submitted by: Pershing County Water Conservation District (Pershing County). e. Name of Project: Humboldt... the Commission's regulations. h. Potential Applicant Contact: Bennie Hodges, Pershing County Water...

A Calculation of Nuclear Heating by Activation Product of Structure Materials for the In-core Irradiation Hole in the HANARO

International Nuclear Information System (INIS)

Noh, Tae Yang; Park, B. G.; Kim, M. S.

2016-01-01

Only delayed gamma heating is considered in this paper. Contribution of the delayed gamma heating is expected to be negligible for the reactor power. For the neutron irradiation, however, the contribution of delayed gamma heating is not negligible issue, and it should be evaluated for safety analysis. Additionally, in the case of temperature-sensitive irradiation targets, the delayed gamma heating should be evaluated precisely. For the HANARO, the delayed gamma heating has been evaluated by modifying the library data of the calculation code or by assuming the heating to be conservative value based on prompt gamma heating. For the method of modifying the library data, however, it should be able to estimate isotopes which contribute to heat generation exactly. And furthermore, it should be concerned to determine modified emission yield of gamma-rays depending on the half-life. For the method of assuming conservative value, it is hard to determine whether the assumed heating value is enough conservative or not. In this study, a methodology for evaluation of nuclear heating by structure materials irradiated for a long time is established with the ORIGEN and MCNP codes. And this method is applied to determine the nuclear heating of the RI capsule in the IR2 irradiation hole in the HANARO. In this paper, the methodology for evaluation of heat generation by irradiated structure materials was established by using the ORIGEN and MCNP codes. From this result, the contribution by farther structures was expected to be negligible. Meanwhile, heat generation by delayed gamma-ray was calculated less than 0.03% of heat generation by prompt radiations. The result of this study indicates that there are some remaining issues for the real situation of the neutron irradiation at HANARO.

Peak Load Regulation and Cost Optimization for Microgrids by Installing a Heat Storage Tank and a Portable Energy System

Directory of Open Access Journals (Sweden)

Hong Zhang

2018-04-01

Full Text Available With the rapid growth of electricity demands, many traditional distributed networks cannot cover their peak demands, especially in the evening. Additionally, with the interconnection of distributed electrical and thermal grids, system operational flexibility and energy efficiency can be affected as well. Therefore, by adding a portable energy system and a heat storage tank to the traditional distributed system, this paper proposes a newly defined distributed network to deal with the aforementioned problems. Simulation results show that by adding a portable energy system, fossil fuel energy consumption and daily operation cost can be reduced by 8% and 28.29%, respectively. Moreover, system peak load regulating capacity can be significantly improved. However, by introducing the portable energy system to the grid, system uncertainty can be increased to some extent. Therefore, chance constrained programming is proposed to control the system while considering system uncertainty. By applying Particle Swarm Optimization—Monte Carlo to solve the chance constrained programming, results show that power system economy and uncertainty can be compromised by selecting appropriate confidence levels α and β. It is also reported that by installing an extra heat storage tank, combined heat and power energy efficiency can be significantly improved and the installation capacity of the battery can be reduced.

DNA damage-responsive Drosophila melanogaster gene is also induced by heat shock

International Nuclear Information System (INIS)

Vivino, A.A.; Smith, M.D.; Minton, K.W.

1986-01-01

A gene isolated by screening Drosophila melanogaster tissue culture cells for DNA damage regulation was also found to be regulated by heat shock. After UV irradiation or heat shock, induction is at the transcriptional level and results in the accumulation of a 1.0-kilobase polyadenylated transcript. The restriction map of the clone bears no resemblance to the known heat shock genes, which are shown to be uninduced by UV irradiation

Fractional single-phase-lagging heat conduction model for describing anomalous diffusion

Directory of Open Access Journals (Sweden)

T.N. Mishra

2016-03-01

Full Text Available The fractional single-phase-lagging (FSPL heat conduction model is obtained by combining scalar time fractional conservation equation to the single-phase-lagging (SPL heat conduction model. Based on the FSPL heat conduction model, anomalous diffusion within a finite thin film is investigated. The effect of different parameters on solution has been observed and studied the asymptotic behavior of the FSPL model. The analytical solution is obtained using Laplace transform method. The whole analysis is presented in dimensionless form. Numerical examples of particular interest have been studied and discussed in details.

Evolutionary conservation of TORC1 components, TOR, Raptor, and LST8, between rice and yeast.