WorldWideScience

Sample records for regeneratives vibrations analyzes

  1. Novel Regenerative Carbon Analyzer for Water Quality Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — One of the highest priorities of a regenerative life support system for manned space missions (to the Moon, Mars, and other remote locations) is to recover and...

  2. Buck-boost converter for simultaneous semi-active vibration control and energy harvesting for electromagnetic regenerative shock absorber

    Science.gov (United States)

    Li, Peng; Zhang, Chongxiao; Kim, Junyoung; Yu, Liangyao; Zuo, Lei

    2014-04-01

    Regenerative semi-active suspensions can capture the previously dissipated vibration energy and convert it to usable electrical energy for powering on-board electronic devices, while achieve both the better ride comfort and improved road handling performance at the same time when certain control is applied. To achieve this objective, the power electronics interface circuit connecting the energy harvester and the electrical loads, which can perform simultaneous vibration control and energy harvesting function is in need. This paper utilized a buck-boost converter for simultaneous semi-active vibration control and energy harvesting with electromagnetic regenerative shock absorber, which utilizes a rotational generator to converter the vibration energy to electricity. It has been found that when the circuit works in discontinuous current mode (DCM), the ratio between the input voltage and current is only related to the duty cycle of the switch pulse width modulation signal. Using this property, the buck-boost converter can be used to perform semi-active vibration control by controlling the load connected between the terminals of the generator in the electromagnetic shock absorber. While performing the vibration control, the circuit always draw current from the shock absorber and the suspension remain dissipative, and the shock absorber takes no additional energy to perform the vibration control. The working principle and dynamics of the circuit has been analyzed and simulations were performed to validate the concept.

  3. Analyzing wind turbine flow interaction through vibration data

    Science.gov (United States)

    Castellani, Francesco; D'Elia, Gianluca; Astolfi, Davide; Mucchi, Emiliano; Giorgio, Dalpiaz; Terzi, Ludovico

    2016-09-01

    Wind turbines commonly undergo non-stationary flow and, not rarely, even rather extreme phenomena. In particular, rough terrains represent a challenging testing ground, because of the combination of terrain-driven flow and wakes. It is therefore crucial to assess the impact of dynamic loads on the turbines. In this work, tower and drive-train vibrations are analyzed, from a subcluster of four turbines of a wind farm sited in a very complex terrain. The main outcome of the study is that it is possible to start from the analysis of wind conditions and interpret how wakes manifest in the vibrations of the turbines, both at structural level (tower vibrations) and at the drive-train level. This wind to gear approach therefore allows to build a connection between a flow phenomenon and a mechanical phenomenon (vibrations) and can be precious to assess loads in different working conditions.

  4. Analyzing a Vibrating Wire Transducer using Coupled Resonator Circuits

    Directory of Open Access Journals (Sweden)

    POP, S.

    2015-08-01

    Full Text Available This paper intends to be an approach on the vibrating wire transducer from the perspective of the necessary rules used for a correct measurement procedure. There are several studies which analyze the vibrating wire transducer as a mechanical system. However, a comparative time-domain analysis between the mechanical and the electrical model is lacking. The transducer analysis is based on a theoretical analysis of the equivalent circuit, on both excitation and response time intervals. The electrical model consists of two magnetic coupled resonating circuits. When connected to an excitation source, there will be an energy transfer from the coil to the wire. The maximum energy transfer will occur at the vibrating wire's frequency of resonance. Using the transient regime analysis, it has been proven that, in the response time interval - when the wire vibrates freely, the current through the circuit that models the wire describes the oscillating movement of the wire. A complex signal is obtained, that contains both coil's and wire's frequencies of resonance, strongly dependent with theirs parasitic elements. The mathematical analysis highlights the similarity between mechanical and electrical model and the procedures in order to determine the wire frequency of resonance from the output signal.

  5. System and method of analyzing vibrations and identifying failure signatures in the vibrations

    Science.gov (United States)

    Huang, Norden E. (Inventor); Salvino, Liming W. (Inventor)

    2008-01-01

    An apparatus, computer program product and method of analyzing structures. Intrinsic Mode Functions (IMFs) are extracted from the data and the most energetic IMF is selected. A spline is fit to the envelope for the selected IMF. The spline derivative is determined. A stability spectrum is developed by separating the positive and negative results into two different spectra representing stable (positive) and unstable (negative) damping factors. The stability spectrum and the non-linearity indicator are applied to the data to isolate unstable vibrations.

  6. Method of analyzing vibration characteristics of armature system of hermetically sealed electromagnetic relay

    Institute of Scientific and Technical Information of China (English)

    REN Wan-bin; CUI Li; LUO Fu-biao; ZHAI Guo-fu

    2007-01-01

    Published research is minimal on vibration characteristics of hermetically sealed electromagnetic relay (EMR) exposed to mechanical environment. The vibration characteristics of armature system, link contact system with electromagnetic system will cause EMR malfunction. The nonlinear dynamics model of armature systems was studied by considering electromagnetic attraction force and opposite mechanical force in this paper. Angular displacements of armature under different sinusoidal vibration conditions are solved in order to obtain the failure mode result from armature system. Vibration tests showed the presented analyzing method is suitable for EMR. The conclusions are instructive for increasing vibration resistance of armature systems of EMR, and are significant for reliability design of switch apparatus.

  7. [Research of working condition monitoring and analyzing system for rotating anode X-ray tube based on the vibration measurement].

    Science.gov (United States)

    Wu, Hao; Wang, Weidong; Yan, Yong; Zhang, Shuai; Zu, Hefei; Chen, Weibin

    2011-01-01

    A non-invasive detecting and analyzing method which used to monitor the working condition of rotating anode X-ray was proposed. Based on the NI development environment, accelerometer, 24-bit high resolution data acquisition card and personal computer were connected to construct the system for collecting the vibration signal of X-ray tube. Results demonstrate that the system could acquire and store the vibration data of X-ray tube quickly and efficiently. The characteristics of vibration, were extracted and processed, which proposed a new approach to detect the malfunction of rotating anode X-ray early and effectively.

  8. Analyzing and exemplify the phenomenon of lossing control in vibration experiment

    Institute of Scientific and Technical Information of China (English)

    Chang Shaoli; Ji Chunyang; Kuang Zhili

    2008-01-01

    With science and technology development,vibration testing as the most important item in reliability test is be-coming more and more important,at the same time,vibrate condition becoming more and more complicated,the phe-nomenon increases that the output of controller goes beyond controlling range so that destroy the specimen.In this pa-per,some skills such as how to set the parameters of force controller,where to place the sensor,which material to be chosen and which skills to be used while making jigs were introduced to avoid the just matter.At last,some examples were given to prove the validity of the method proposed.

  9. Regenerative endodontics.

    Science.gov (United States)

    Simon, S; Smith, A J

    2014-03-01

    Significant advances in our understanding of the biological processes involved in tooth development and repair at the cellular and molecular levels have underpinned the newly emerging area of regenerative endodontics. Development of treatment protocols based on exploiting the natural wound healing properties of the dental pulp and applying tissue engineering principles has allowed reporting of case series showing preservation of tissue vitality and apexogenesis. To review current case series reporting regenerative endodontics. Current treatment approaches tend to stimulate more reparative than regenerative responses in respect of the new tissue generated, which often does not closely resemble the physiological structure of dentine-pulp. However, despite these biological limitations, such techniques appear to offer significant promise for improved treatment outcomes. Improved biological outcomes will likely emerge from the many experimental studies being reported and will further contribute to improvements in clinical treatment protocols.

  10. Regenerative Endodontics.

    Science.gov (United States)

    Feigin, Kristina; Shope, Bonnie

    2017-09-01

    Regenerative endodontics has been defined as "biologically based procedure designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex." This is an exciting and rapidly evolving field of human endodontics for the treatment of immature permanent teeth with infected root canal systems. These procedures have shown to be able not only to resolve pain and apical periodontitis but continued root development, thus increasing the thickness and strength of the previously thin and fracture-prone roots. In the last decade, over 80 case reports, numerous animal studies, and series of regenerative endodontic cases have been published. However, even with multiple successful case reports, there are still some remaining questions regarding terminology, patient selection, and procedural details. Regenerative endodontics provides the hope of converting a nonvital tooth into vital one once again.

  11. Regenerative engineering

    CERN Document Server

    Laurencin, Cato T

    2013-01-01

    Regenerative Engineering: The Future of Medicine Saadiq F. El-Amin III , MD , PhD; Joylene W.L. Thomas, MD ; Ugonna N. Ihekweazu, MD ; Mia D. Woods, MS; and Ashim Gupta, MSCell Biology Gloria Gronowicz, PhD and Karen Sagomonyants, DMDStem Cells and Tissue Regeneration Kristen Martins-Taylor, PhD; Xiaofang Wang, MD , PhD; Xue-Jun Li, PhD; and Ren-He Xu, MD , PhDIntroduction to Materials Science Sangamesh G. Kumbar, PhD and Cato T. Laurencin, MD , PhDBiomaterials A. Jon Goldberg, PhD and Liisa T. Kuhn, PhDIn Vitro Assessment of Cell-Biomaterial Interactions Yong Wang, PhDHost Response to Biomate

  12. Method for analyzing electromagnetic-force-induced vibration and noise analysis; Denjiryoku reiki ni yoru dendoki no shindo hoshaon kaisekiho

    Energy Technology Data Exchange (ETDEWEB)

    Shiohata, K.; Nemoto, K.; Nagawa, Y.; Sakamoto, S.; Kobayashi, T.; Ito, M.; Koharagi, H. [Hitachi, Ltd, Tokyo (Japan)

    1998-11-01

    In this analysis method, electromagnetic force calculated by 2-dimensional analysis is transformed into external force for 3-dimensional structural-vibration analysis. And a modeling procedure for a vibrating structure is developed. Further, a space-modal-resonance criteria which relates electromagnetic force to structural-vibration or noise is introduced. In the structural-vibration analysis, the finite element method is used; and in the noise analysis, the boundary element method is used. Finally, vibration and noise of an induction motor are calculated using this criteria. Consequently, high-accuracy modeling is achieved and noise the calculated by the simulation almost coincides with that obtained by experiments. And it is clarified that the-space-modal resonance criteria is effective in numerical simulation. 11 refs., 9 figs., 3 tabs.

  13. Analyzing the nonlinear vibrational wave differential equation for the simplified model of Tower Cranes by Algebraic Method

    Science.gov (United States)

    Akbari, M. R.; Ganji, D. D.; Ahmadi, A. R.; Kachapi, Sayyid H. Hashemi

    2014-03-01

    In the current paper, a simplified model of Tower Cranes has been presented in order to investigate and analyze the nonlinear differential equation governing on the presented system in three different cases by Algebraic Method (AGM). Comparisons have been made between AGM and Numerical Solution, and these results have been indicated that this approach is very efficient and easy so it can be applied for other nonlinear equations. It is citable that there are some valuable advantages in this way of solving differential equations and also the answer of various sets of complicated differential equations can be achieved in this manner which in the other methods, so far, they have not had acceptable solutions. The simplification of the solution procedure in Algebraic Method and its application for solving a wide variety of differential equations not only in Vibrations but also in different fields of study such as fluid mechanics, chemical engineering, etc. make AGM be a powerful and useful role model for researchers in order to solve complicated nonlinear differential equations.

  14. [Regenerative approach for COPD].

    Science.gov (United States)

    Kubo, Hiroshi

    2011-10-01

    No treatment to cure of chronic obstructive pulmonary disease (COPD) is available. Regenerative medicine is one of promising areas for this intractable disease. Several reagents and growth factors are known to promote lung regeneration in small animal models. However, regenerative medicines for human lungs are not achieved yet. Recent advances in stem cell biology and tissue engineering have expanded our understanding of lung endogenous stem cells, and this new knowledge provides us with new ideas for future regenerative therapy for lung diseases. Although lungs are the most challenging organ for regenerative medicine, our cumulative knowledge of lung regeneration and of endogenous progenitor cells makes clear the possibilities for regenerative approach to COPD.

  15. Analyzing the vibrational response of an AFM cantilever in liquid with the consideration of tip mass by comparing the hydrodynamic and contact repulsive force models in higher modes

    Science.gov (United States)

    Korayem, Moharam Habibnejad; Nahavandi, Amir

    2017-04-01

    This paper investigates the vibration of a tapping-mode Atomic Force Microscope (AFM) cantilever covered with two whole piezoelectric layers in a liquid medium. The authors of this article have already modeled the vibration of a cantilever immersed in liquid over rough surfaces. Five new ideas have been considered for improving the results of the previous work. Mass and damping of a cantilever probe tip have been considered. Since the probe tip of an AFM cantilever has a mass, which can itself affect the natural frequency of vibration, the significance of this mass has been explored. Also, two hydrodynamic force models for analyzing the mass and damping added to a cantilever in liquid medium have been evaluated. In modeling the vibration of a cantilever in liquid, simplifications are made to the theoretical equations used in the modeling, which may make the obtained results different from those in the real case. So, two hydrodynamic force models are introduced and compared with each other. In addition to the already introduced DMT model, the JKR model has been proposed. The forces acting on a probe tip have attractive and repulsive effects. The attractive Van der Waals force can vary depending on the surface smoothness or roughness, and the repulsive contact force, which is independent of the type of surface roughness and usually varies with the hardness or softness of a surface. When the first mode is used in the vibration of an AFM cantilever, the changes of the existing physical parameters in the simulation do not usually produce a significant difference in the response. Thus, three cantilever vibration modes have been investigated. Finally, an analytical approach for obtaining the response of equations is presented which solves the resulting motion equation by the Laplace method and, thus, a time function is obtained for cantilever deflection is determined. Also, using the COMSOL software to model a cantilever in a liquid medium, the computed natural

  16. Prototype partial one-third octave band spectrum analyzer for acoustic, vibration and other wideband data for flight applications

    Science.gov (United States)

    1973-01-01

    The design refinement of a compact frequency analyzer for measurement and analysis on board flight vehicles is discussed. The analyzer has been constructed in a partial one-third octave band configuration with six filters and detectors spaced by the square root of 10 from 316 Hz to 100,000 Hz and a broadband detector channel. The analyzer has been tested over a temperature range of 40 to 120 F at a pressure of one atmosphere, and at a temperature of 75 F at an absolute pressure of 0.000001 torr, and has demonstrated at least 60 db of dynamic range.

  17. Regenerative Hydride Heat Pump

    Science.gov (United States)

    Jones, Jack A.

    1992-01-01

    Hydride heat pump features regenerative heating and single circulation loop. Counterflow heat exchangers accommodate different temperatures of FeTi and LaNi4.7Al0.3 subloops. Heating scheme increases efficiency.

  18. Regenerative Hydride Heat Pump

    Science.gov (United States)

    Jones, Jack A.

    1992-01-01

    Hydride heat pump features regenerative heating and single circulation loop. Counterflow heat exchangers accommodate different temperatures of FeTi and LaNi4.7Al0.3 subloops. Heating scheme increases efficiency.

  19. Advances in Regenerative medicine

    OpenAIRE

    2011-01-01

    PREFACE In order to better introduce this book, it is important to define regenerative medicine as this field is built through a combination of multiple elements including living cells, matrix to support the living cells (i.e. a scaffold), and cell communicators (or signaling systems) to stimulate the cells, and their surrounding environment to grow and develop into new tissue or organ. Indeed, regenerative medicine is an emerging multidisciplinary field involving biology, medicine, and ...

  20. The Parameters Optimizing Design of Double Suspension Arm Torsion Bar in the Electric Sight-Seeing Car by Random Vibration Analyzing Method

    Directory of Open Access Journals (Sweden)

    Shui-Ting Zhou

    2017-01-01

    Full Text Available This study is about the impact of the performance and the sensitivity analysis for parameters of the torsion bar suspension in the electric sight-seeing car, which the authors’ laboratory designed and which is used in the authors’ university. The suspension stiffness was calculated by using the virtual work principle, the vector algebra, and tensor of finite rotation methods and was verified by the ADAMS software. Based on the random vibration analysis method, the paper analyzed the dynamic tire load (DTL, suspension working space (SWS, and comfort performance parameters. For the purpose of decreasing the displacement of the suspension and limiting the frequency of impacting the stop block, the paper examined the three parameters and optimized the basic parameters of the torsion bar. The results show that the method achieves a great effect and contributes an accurate value for the general layout design.

  1. Regenerative superheated steam turbine cycles

    Science.gov (United States)

    Fuller, L. C.; Stovall, T. K.

    1980-01-01

    PRESTO computer program was developed to analyze performance of wide range of steam turbine cycles with special attention given to regenerative superheated steam turbine cycles. It can be used to model standard turbine cycles, including such features as process steam extraction, induction and feedwater heating by external sources, peaking, and high back pressure. Expansion line efficiencies, exhaust loss, leakages, mechanical losses, and generator losses are used to calculate cycle heat rate and generator output. Program provides power engineer with flexible aid for design and analysis of steam turbine systems.

  2. Summary of: Regenerative endodontics.

    Science.gov (United States)

    Clark, Stephen J

    2014-03-01

    Significant advances in our understanding of the biological processes involved in tooth development and repair at the cellular and molecular levels have underpinned the newly emerging area of regenerative endodontics. Development of treatment protocols based on exploiting the natural wound healing properties of the dental pulp and applying tissue engineering principles has allowed reporting of case series showing preservation of tissue vitality and apexogenesis. To review current case series reporting regenerative endodontics. Current treatment approaches tend to stimulate more reparative than regenerative responses in respect of the new tissue generated, which often does not closely resemble the physiological structure of dentine-pulp. However, despite these biological limitations, such techniques appear to offer significant promise for improved treatment outcomes. Improved biological outcomes will likely emerge from the many experimental studies being reported and will further contribute to improvements in clinical treatment protocols.

  3. Regenerative similariton laser

    Directory of Open Access Journals (Sweden)

    Thibault North

    2016-05-01

    Full Text Available Self-pulsating lasers based on cascaded reshaping and reamplification (2R are capable of initiating ultrashort pulses despite the accumulation of large amounts of nonlinearities in all-fiber resonators. The spectral properties of pulses in self-similar propagation are compatible with cascaded 2R regeneration by offset filtering, making parabolic pulses suitable for the design of a laser of this recently introduced class. A new type of regenerative laser giving birth to similaritons is numerically investigated and shows that this laser is the analog of regenerative sources based solely on self-phase modulation and offset filtering. The regenerative similariton laser does not suffer from instabilities due to excessive nonlinearities and enables ultrashort pulse generation in a simple cavity configuration.

  4. Cryogenic regenerative heat exchangers

    CERN Document Server

    Ackermann, Robert A

    1997-01-01

    An in-depth survey of regenerative heat exchangers, this book chronicles the development and recent commercialization of regenerative devices for cryogenic applications. Chapters cover historical background, concepts, practical applications, design data, and numerical solutions, providing the latest information for engineers to develop advanced cryogenic machines. The discussions include insights into the operation of a regenerator; descriptions of the cyclic and fluid temperature distributions in a regenerator; data for various matrix geometries and materials, including coarse and fine bronze, stainless steel-woven wire mesh screens, and lead spheres; and unique operating features of cryocoolers that produce deviations from ideal regenerator theory.

  5. Bioprinting in Regenerative Medicine

    Directory of Open Access Journals (Sweden)

    Manuela Monti

    2016-02-01

    Full Text Available Prof. Turksen is a very well known scientist in the stem cell biology field and he is also internationally known for his fundamental studies on claudin-6. In addition to his research activity he is editor for the Stem Cell Biology and Regenerative Medicine series (Humana Press and editor-in-chief of Stem Cell Reviews and Reports.....

  6. Regenerative photonic therapy: Review

    Science.gov (United States)

    Salansky, Natasha; Salansky, Norman

    2012-09-01

    After four decades of research of photobiomodulation phenomena in mammals in vitro and in vivo, a solid foundation is created for the use of photobiomodulation in regenerative medicine. Significant accomplishments are achieved in animal models that demonstrate opportunities for photo-regeneration of injured or pathological tissues: skin, muscles and nerves. However, the use of photobiomodulation in clinical studies leads to controversial results while negative or marginal clinical efficacy is reported along with positive findings. A thor ough analysis of requirements to the optical parameters (dosimetry) for high efficacy in photobimodulation led us to the conclusion that there are several misconceptions in the clinical applications of low level laser therapy (LLLT). We present a novel appr oach of regenerative photonic therapy (RPT) for tissue healing and regeneration that overcomes major drawbacks of LLLT. Encouraging clinical results on RPT efficacy are presented. Requirements for RPT approach and vision for its future development for tissue regeneration is discussed.

  7. Regenerative Endodontics: Burning Questions.

    Science.gov (United States)

    Smith, Anthony J; Cooper, Paul R

    2017-09-01

    Pulp regeneration and its clinical translation into regenerative endodontic procedures are receiving increasing research attention, leading to significant growth of the published scientific and clinical literature within these areas. Development of research strategies, which consider patient-, clinician-, and scientist-based outcomes, will allow greater focus on key research questions driving more rapid clinical translation. Three key areas of focus for these research questions should include cells, signaling, and infection/inflammation. A translational pathway is envisaged in which clinical approaches are increasingly refined to provide regenerative endodontic protocols that are based on a robust understanding of the physiological processes and events responsible for the normal secretion, structure, and biological behavior of pulpal tissue. Copyright © 2017 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  8. A Novel Energy-regenerative Active Suspension for Vehicles

    Institute of Scientific and Technical Information of China (English)

    ZHENG Xue-chun; YU Fan; ZHANG Yong-chao

    2008-01-01

    In order to regenerate electric power from the vibration excited by road unevenness, a novel energy- regenerative active suspension for vehicles was proposed with the description of its structure and its working principle with two modes switched in different operating conditions. Then, the novel active system was modeled and simulated to show the performance improvement in ride comfort in its electrical motor mode. Finally, the performance tests of the actuator prototype were carried out, which proves its capability for damping in its regenerative braking mode. The research results can provide useful guidance for the similar electrical active suspension design and development.

  9. Regenerative feedback resonant circuit

    Science.gov (United States)

    Jones, A. Mark; Kelly, James F.; McCloy, John S.; McMakin, Douglas L.

    2014-09-02

    A regenerative feedback resonant circuit for measuring a transient response in a loop is disclosed. The circuit includes an amplifier for generating a signal in the loop. The circuit further includes a resonator having a resonant cavity and a material located within the cavity. The signal sent into the resonator produces a resonant frequency. A variation of the resonant frequency due to perturbations in electromagnetic properties of the material is measured.

  10. Cytomics in regenerative medicine

    Science.gov (United States)

    Tárnok, Attila; Pierzchalski, Arkadiusz

    2008-02-01

    Cytomics is the high-content analysis of cell-systems [6, 78]. The area of Cytomics and Systems Biology received great attention during the last years as it harbours the promise to substantially impact on various fields of biomedicine, drug discovery, predictive medicine [6] and may have major potential for regenerative medicine. In regenerative medicine Cytomics includes process control of cell preparation and culturing using non-invasive detection techniques, quality control and standardization for GMP and GLP conformity and even prediction of cell fate based on sophisticated data analysis. Cytomics requires quantitative and stoichiometric single cell analysis. In some areas the leading cytometric techniques represent the cutting edge today. Many different applications/variations of multicolour staining were developed for flow- or slide-based cytometry (SBC) analysis of suspensions and sections to whole animal analysis [78]. SBC has become an important analytical technology in drug discovery, diagnosis and research and is an emerging technology for systems analysis [78]. It enables high-content high-throughput measurement of cell suspensions, cell cultures and tissues. In the last years various commercial SBC instruments were launched principally enabling to perform similar tasks. Standardisation as well as comparability of different instruments is a major challenge. Hyperspectral optical imaging may be implemented in SBC analysis for label free cell detection based on cellular autofluorescence [3]. All of these developments push the systemic approach of the analysis of biological specimens to enhance the outcome of regenerative medicine.

  11. 基于模糊理论的虚拟振动分析仪设计%Design of Virtual Vibration Analyzer Based on Fuzzy Theory

    Institute of Scientific and Technical Information of China (English)

    梁允魁; 胡元; 王常江

    2011-01-01

    介绍了用模糊理论建立虚拟仪器.以模糊理论为基础,确定隶属函数类型,模糊子集的个数,以及对应的隶属函数的参数,并将这些信息以字符串形式传递到Matlab的工作空间中,在Labview软件平台下,通过程序接口调用相应的Matlab程序,建立模糊系统.模糊系统根据硬件采集信号所得的数值来确定机器所处的状态,本设计以齿轮箱为例设计虚拟振动分析仪以检测齿轮箱的运动状态.%This paper introduces the use of the fuzzy theory to establish virtual instrument. Based on Fuzzy theory,the membership function type,the number of Fuzzy subsets and the corresponding parameters are determined. This information is passed as a character string to the Matlab workspace. In the Labview platform through the program interface, the appropriate Matlab program is called then the Fuzzy system is established. Based on the collection of hardware signal data, the state of machine is determined in Fuzzy system. The gear box is taken for example to design Virtual Vibration analyzer to detect the state of motion of gear box.

  12. Regenerative Medicine Build-Out

    OpenAIRE

    Terzic, Andre; Pfenning, Michael A.; Gregory J Gores; Harper, C. Michel

    2015-01-01

    Summary Regenerative technologies strive to boost innate repair processes and restitute normative impact. Deployment of regenerative principles into practice is poised to usher in a new era in health care, driving radical innovation in patient management to address the needs of an aging population challenged by escalating chronic diseases. There is urgency to design, execute, and validate viable paradigms for translating and implementing the science of regenerative medicine into tangible heal...

  13. Center for Neuroscience & Regenerative Medicine

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Neuroscience and Regenerative Medicine (CNRM) was established as a collaborative intramural federal program involving the U.S. Department of Defense...

  14. Regenerative adsorbent heat pump

    Science.gov (United States)

    Jones, Jack A. (Inventor)

    1991-01-01

    A regenerative adsorbent heat pump process and system is provided which can regenerate a high percentage of the sensible heat of the system and at least a portion of the heat of adsorption. A series of at least four compressors containing an adsorbent is provided. A large amount of heat is transferred from compressor to compressor so that heat is regenerated. The process and system are useful for air conditioning rooms, providing room heat in the winter or for hot water heating throughout the year, and, in general, for pumping heat from a lower temperature to a higher temperature.

  15. REGENERATIVE TRANSISTOR AMPLIFIER

    Science.gov (United States)

    Kabell, L.J.

    1958-11-25

    Electrical circults for use in computers and the like are described. particularly a regenerative bistable transistor amplifler which is iurned on by a clock signal when an information signal permits and is turned off by the clock signal. The amplifier porforms the above function with reduced power requirements for the clock signal and circuit operation. The power requirements are reduced in one way by employing transformer coupling which increases the collector circuit efficiency by eliminating the loss of power in the collector load resistor.

  16. Regenerative adsorption distillation system

    KAUST Repository

    Ng, Kim Choon

    2013-12-26

    There is provided a regenerative adsorption distillation system comprising a train of distillation effects in fluid communication with each other. The train of distillation effects comprises at least one intermediate effect between the first and last distillation effects of the train, each effect comprising a vessel and a condensing tube for flow of a fluid therein. The system further comprises a pair of adsorption-desorption beds in vapour communication with the last effect and at least one intermediate effect, wherein the beds contain an adsorbent that adsorbs vapour from the last effect and transmits desorbed vapour into at least one of the intermediate effect.

  17. Regenerative Medicine Build-Out.

    Science.gov (United States)

    Terzic, Andre; Pfenning, Michael A; Gores, Gregory J; Harper, C Michel

    2015-12-01

    Regenerative technologies strive to boost innate repair processes and restitute normative impact. Deployment of regenerative principles into practice is poised to usher in a new era in health care, driving radical innovation in patient management to address the needs of an aging population challenged by escalating chronic diseases. There is urgency to design, execute, and validate viable paradigms for translating and implementing the science of regenerative medicine into tangible health benefits that provide value to stakeholders. A regenerative medicine model of care would entail scalable production and standardized application of clinical grade biotherapies supported by comprehensive supply chain capabilities that integrate sourcing and manufacturing with care delivery. Mayo Clinic has rolled out a blueprint for discovery, translation, and application of regenerative medicine therapies for accelerated adoption into the standard of care. To establish regenerative medical and surgical service lines, the Mayo Clinic model incorporates patient access, enabling platforms and delivery. Access is coordinated through a designated portal, the Regenerative Medicine Consult Service, serving to facilitate patient/provider education, procurement of biomaterials, referral to specialty services, and/or regenerative interventions, often in clinical trials. Platforms include the Regenerative Medicine Biotrust and Good Manufacturing Practice facilities for manufacture of clinical grade products for cell-based, acellular, and/or biomaterial applications. Care delivery leverages dedicated interventional suites for provision of regenerative services. Performance is tracked using a scorecard system to inform decision making. The Mayo Clinic roadmap exemplifies an integrated organization in the discovery, development, and delivery of regenerative medicine within a growing community of practice at the core of modern health care. Regenerative medicine is at the vanguard of health care

  18. Regenerative Medicine Build-Out

    Science.gov (United States)

    Pfenning, Michael A.; Gores, Gregory J.; Harper, C. Michel

    2015-01-01

    Summary Regenerative technologies strive to boost innate repair processes and restitute normative impact. Deployment of regenerative principles into practice is poised to usher in a new era in health care, driving radical innovation in patient management to address the needs of an aging population challenged by escalating chronic diseases. There is urgency to design, execute, and validate viable paradigms for translating and implementing the science of regenerative medicine into tangible health benefits that provide value to stakeholders. A regenerative medicine model of care would entail scalable production and standardized application of clinical grade biotherapies supported by comprehensive supply chain capabilities that integrate sourcing and manufacturing with care delivery. Mayo Clinic has rolled out a blueprint for discovery, translation, and application of regenerative medicine therapies for accelerated adoption into the standard of care. To establish regenerative medical and surgical service lines, the Mayo Clinic model incorporates patient access, enabling platforms and delivery. Access is coordinated through a designated portal, the Regenerative Medicine Consult Service, serving to facilitate patient/provider education, procurement of biomaterials, referral to specialty services, and/or regenerative interventions, often in clinical trials. Platforms include the Regenerative Medicine Biotrust and Good Manufacturing Practice facilities for manufacture of clinical grade products for cell-based, acellular, and/or biomaterial applications. Care delivery leverages dedicated interventional suites for provision of regenerative services. Performance is tracked using a scorecard system to inform decision making. The Mayo Clinic roadmap exemplifies an integrated organization in the discovery, development, and delivery of regenerative medicine within a growing community of practice at the core of modern health care. Significance Regenerative medicine is at the

  19. Esophagus and regenerative medicine

    Institute of Scientific and Technical Information of China (English)

    Ricardo Londono; Blair A Jobe; Toshitaka Hoppo; Stephen F Badylak

    2012-01-01

    In addition to squamous cell carcinoma,the incidence of Barrett's esophagus with high-grade dysplasia and esophageal adenocarcinoma is rapidly increasing worldwide.Unfortunately,the current standard of care for esophageal pathology involves resection of the affected tissue,sometimes involving radical esophagectomy.Without exception,these procedures are associated with a high morbidity,compromised quality of life,and unacceptable mortality rates.Regenerative medicine approaches to functional tissue replacement include the use of biological and synthetic scaffolds to promote tissue remodeling and growth.In the case of esophageal repair,extracellular matrix (ECM) scaffolds have proven to be effective for the reconstruction of small patch defects,anastomosis reinforcement,and the prevention of stricture formation after endomucosal resection (EMR).More so,esophageal cancer patients treated with ECM scaffolds have shown complete restoration of a normal,functional,and disease-free epithelium after EMR.These studies provide evidence that a regenerative medicine approach may enable aggressive resection of neoplastic tissue without the need for radical esophagectomy and its associated complications.

  20. Giant hepatic regenerative nodules in Alagille syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Rapp, Jordan B. [Lewis Katz School of Medicine at Temple University, Department of Radiology, Temple University Hospital, Philadelphia, PA (United States); Bellah, Richard D.; Anupindi, Sudha A. [The Children' s Hospital of Philadelphia, Department of Radiology, Philadelphia, PA (United States); University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA (United States); Maya, Carolina [The Children' s Hospital of Philadelphia, Department of Radiology, Philadelphia, PA (United States); Pawel, Bruce R. [University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA (United States); The Children' s Hospital of Philadelphia, Department of Pathology and Laboratory Medicine, Philadelphia, PA (United States)

    2017-02-15

    Children with Alagille syndrome undergo surveillance radiologic examinations as they are at risk for developing cirrhosis and hepatocellular carcinoma. There is limited literature on the imaging of liver masses in Alagille syndrome. We report the ultrasound (US) and magnetic resonance imaging (MRI) appearances of incidental benign giant hepatic regenerative nodules in this population. To describe the imaging findings of giant regenerative nodules in patients with Alagille syndrome. A retrospective search of the hospital database was performed to find all cases of hepatic masses in patients with Alagille syndrome during a 10-year period. Imaging, clinical charts, laboratory data and available pathology were reviewed and analyzed and summarized for each patient. Twenty of 45 patients with confirmed Alagille syndrome had imaging studies. Of those, we identified six with giant focal liver masses. All six patients had large central hepatic masses that were remarkably similar on US and MRI, in addition to having features of cirrhosis. In each case, the mass was located in hepatic segment VIII and imaging showed the mass splaying the main portal venous branches at the hepatic hilum, as well as smaller portal and hepatic venous branches coursing through them. On MRI, signal intensity of the mass was isointense to liver on T1-weighted sequences in four of six patients, but hyperintense on T1 in two of six patients. In all six cases, the mass was hypointense on T2- weighted sequences. The mass post-contrast was isointense to adjacent liver in all phases in five the cases. Five out of six patients had pathological correlation demonstrating preserved ductal architecture confirming the final diagnosis of a regenerative nodule. Giant hepatic regenerative nodules with characteristic US and MR features can occur in patients with Alagille syndrome with underlying cirrhosis. Recognizing these lesions as benign giant hepatic regenerative nodules should, thereby, mitigate any need for

  1. Aarhus Regenerative Orthopaedics Symposium (AROS)

    DEFF Research Database (Denmark)

    Foldager, Casper B.; Bendtsen, Michael; Berg, Lise C.

    2016-01-01

    to musculoskeletal pain and disability. The Aarhus Regenerative Orthopaedics Symposium (AROS) 2015 was motivated by the need to address regenerative challenges in an ageing population by engaging clinicians, basic scientists, and engineers. In this position paper, we review our contemporary understanding of societal...

  2. Design and Implementation of a Regenerative Shock Absorber

    OpenAIRE

    Maravandi, Amir

    2015-01-01

    In this thesis, the development of a novel regenerative shock absorber sized for a passengercar suspension system is studied. In the first phase, DC and AC rotary machines along with charging circuits, to be used in the energy conversion stage of the proposed shock absorber are analyzed. In this analysis, the rotary damping coefficients provided by these systems are obtained following by experimental results.In the second phase, the development of a novel regenerative shock absorber in a proo...

  3. A review of the regenerative endodontic treatment procedure

    Directory of Open Access Journals (Sweden)

    Bin-Na Lee,

    2015-08-01

    Full Text Available Traditionally, apexification has been used to treat immature permanent teeth that have lost pulp vitality. This technique promotes the formation of an apical barrier to close the open apex so that the filling materials can be confined to the root canal. Because tissue regeneration cannot be achieved with apexification, a new technique called regenerative endodontic treatment was presented recently to treat immature permanent teeth. Regenerative endodontic treatment is a treatment procedure designed to replace damaged pulp tissue with viable tissue which restores the normal function of the pulp-dentin structure. After regenerative endodontic treatment, continued root development and hard tissue deposition on the dentinal wall can occur under ideal circumstances. However, it is difficult to predict the result of regenerative endodontic treatment. Therefore, the purpose of this study was to summarize multiple factors effects on the result of regenerative endodontic treatment in order to achieve more predictable results. In this study, we investigated the features of regenerative endodontic treatment in comparison with those of other pulp treatment procedures and analyzed the factors that have an effect on regenerative endodontic treatment.

  4. Active Magnetic Regenerative Liquefier

    Energy Technology Data Exchange (ETDEWEB)

    Barclay, John A. [Heracles Energy Corporation d.b.a. Prometheus Energy, Washington, DC (United States); Oseen-Send, Kathryn [Heracles Energy Corporation d.b.a. Prometheus Energy, Washington, DC (United States); Ferguson, Luke [Heracles Energy Corporation d.b.a. Prometheus Energy, Washington, DC (United States); Pouresfandiary, Jamshid [Heracles Energy Corporation d.b.a. Prometheus Energy, Washington, DC (United States); Cousins, Anand [Heracles Energy Corporation d.b.a. Prometheus Energy, Washington, DC (United States); Ralph, Heather [Heracles Energy Corporation d.b.a. Prometheus Energy, Washington, DC (United States); Hampto, Tom [Heracles Energy Corporation d.b.a. Prometheus Energy, Washington, DC (United States)

    2016-01-12

    This final report for the DOE Project entitled Active Magnetic Regenerative Liquefier (AMRL) funded under Grant DE-FG36-08GO18064 to Heracles Energy Corporation d.b.a. Prometheus Energy (Heracles/Prometheus) describes an active magnetic regenerative refrigerator (AMRR) prototype designed and built during the period from July 2008 through May 2011. The primary goal of this project was to make significant technical advances toward highly efficient liquefaction of hydrogen. Conventional hydrogen liquefiers at any scale have a maximum FOM of ~0.35 due primarily to the intrinsic difficulty of rapid, efficient compression of either hydrogen or helium working gases. Numerical simulation modeling of high performance AMRL designs indicates certain designs have promise to increase thermodynamic efficiency from a FOM of ~0.35 toward ~0.5 to ~0.6. The technical approach was the use of solid magnetic working refrigerants cycled in and out of high magnetic fields to build an efficient active regenerative magnetic refrigeration module providing cooling power for AMRL. A single-stage reciprocating AMRR with a design temperature span from ~290 K to ~120 K was built and tested with dual magnetic regenerators moving in and out of the conductively-cooled superconducting magnet subsystem. The heat transfer fluid (helium) was coupled to the process stream (refrigeration/liquefaction load) via high performance heat exchangers. In order to maximize AMRR efficiency a helium bypass loop with adjustable flow was incorporated in the design because the thermal mass of magnetic refrigerants is higher in low magnetic field than in high magnetic field. Heracles/Prometheus designed experiments to measure AMRR performance under a variety of different operational parameters such as cycle frequency, magnetic field strength, heat transfer fluid flow rate, amount of bypass flow of the heat transfer fluid while measuring work input, temperature span, cooling capability as a function of cold temperature

  5. Bimix antimicrobial scaffolds for regenerative endodontics.

    Science.gov (United States)

    Palasuk, Jadesada; Kamocki, Krzysztof; Hippenmeyer, Lauren; Platt, Jeffrey A; Spolnik, Kenneth J; Gregory, Richard L; Bottino, Marco C

    2014-11-01

    Eliminating and/or inhibiting bacterial growth within the root canal system has been shown to play a key role in the regenerative outcome. The aim of this study was to synthesize and determine in vitro both the antimicrobial effectiveness and cytocompatibility of bimix antibiotic-containing polydioxanone-based polymer scaffolds. Antibiotic-containing (metronidazole [MET] and ciprofloxacin [CIP]) polymer solutions (distinct antibiotic weight ratios) were spun into fibers as a potential mimic to the double antibiotic paste (DAP, a MET/CIP mixture). Fiber morphology, chemical characteristics, and tensile strength were evaluated by scanning electron microscopy, Fourier transform infrared spectroscopy, and tensile testing, respectively. Antimicrobial efficacy was tested over time (aliquot collection) against Enterococcus faecalis (Ef), Porphyromonas gingivalis (Pg), and Fusobacterium nucleatum (Fn). Similarly, cytotoxicity was evaluated in human dental pulp stem cells. Data were statistically analyzed (P regenerative endodontics. Copyright © 2014 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  6. The pharmacology of regenerative medicine.

    Science.gov (United States)

    Christ, George J; Saul, Justin M; Furth, Mark E; Andersson, Karl-Erik

    2013-07-01

    Regenerative medicine is a rapidly evolving multidisciplinary, translational research enterprise whose explicit purpose is to advance technologies for the repair and replacement of damaged cells, tissues, and organs. Scientific progress in the field has been steady and expectations for its robust clinical application continue to rise. The major thesis of this review is that the pharmacological sciences will contribute critically to the accelerated translational progress and clinical utility of regenerative medicine technologies. In 2007, we coined the phrase "regenerative pharmacology" to describe the enormous possibilities that could occur at the interface between pharmacology, regenerative medicine, and tissue engineering. The operational definition of regenerative pharmacology is "the application of pharmacological sciences to accelerate, optimize, and characterize (either in vitro or in vivo) the development, maturation, and function of bioengineered and regenerating tissues." As such, regenerative pharmacology seeks to cure disease through restoration of tissue/organ function. This strategy is distinct from standard pharmacotherapy, which is often limited to the amelioration of symptoms. Our goal here is to get pharmacologists more involved in this field of research by exposing them to the tools, opportunities, challenges, and interdisciplinary expertise that will be required to ensure awareness and galvanize involvement. To this end, we illustrate ways in which the pharmacological sciences can drive future innovations in regenerative medicine and tissue engineering and thus help to revolutionize the discovery of curative therapeutics. Hopefully, the broad foundational knowledge provided herein will spark sustained conversations among experts in diverse fields of scientific research to the benefit of all.

  7. Human dental pulp stem cell behavior using natural nanotolith/bacterial cellulose scaffolds for regenerative medicine.

    Science.gov (United States)

    Olyveira, Gabriel Molina; Acasigua, Gerson Arisoly Xavier; Costa, Ligia Maria Manzine; Scher, Cristiane Regina; Xavier Filho, Lauro; Pranke, Patricia Helena Lucas; Basmaji, Pierre

    2013-08-01

    Adhesion and Viability study with human dental pulp stem cell using natural nanotolith/bacterial cellulose scaffolds for regenerative medicine are presented at first time in this work. Nanotolith, are osteoinductors, i.e., they stimulate bone regeneration, enabling higher cells migration for bone tissue regeneration formation. This is mainly because nanotoliths are rich minerals present in the internal ear of bony fish. In addition, are part of a system which acts as a depth sensor and balance, acting as a sound vibrations detector and considered essential for the bone mineralization process, as in hydroxiapatites. Nanotoliths influence in bacterial cellulose was analyzed using transmission infrared spectroscopy (FTIR). Results shows that fermentation process and nanotoliths agglomeration decrease initial human dental pulp stem cell adhesion however tested bionanocomposite behavior has cell viability increase over time.

  8. Regenerative Therapy for Retinal Disorders

    Directory of Open Access Journals (Sweden)

    Narsis Daftarian

    2010-01-01

    Full Text Available Major advances in various disciplines of basic sciences including embryology, molecular and cell biology, genetics, and nanotechnology, as well as stem cell biology have opened new horizons for regenerative therapy. The unique characteristics of stem cells prompt a sound understanding for their use in modern regenerative therapies. This review article discusses stem cells, developmental stages of the eye field, eye field transcriptional factors, and endogenous and exogenous sources of stem cells. Recent studies and challenges in the application of stem cells for retinal pigment epithelial degeneration models will be summarized followed by obstacles facing regenerative therapy.

  9. Perivascular cells for regenerative medicine

    NARCIS (Netherlands)

    M. Crisan (Mihaela); M. Corselli (Mirko); W.C. Chen (William); B. Péault (Bruno)

    2012-01-01

    textabstractMesenchymal stem/stromal cells (MSC) are currently the best candidate therapeutic cells for regenerative medicine related to osteoarticular, muscular, vascular and inflammatory diseases, although these cells remain heterogeneous and necessitate a better biological characterization. We an

  10. STEM CELLS IN REGENERATIVE ENDODONTICS

    National Research Council Canada - National Science Library

    T Nivethithan; Manish Ranjan

    2017-01-01

    Endodontic treatment is helpful in saving millions of teeth each year, but at present the focus has shifted towards regenerative approaches as an ideal form of therapy to treat diseased or necrotic pulp tissues...

  11. Personalized Regenerative Medicine.

    Science.gov (United States)

    Arjmand, Babak; Goodarzi, Parisa; Mohamadi-Jahani, Fereshteh; Falahzadeh, Khadijeh; Larijani, Bagher

    2017-03-01

    Personalized medicine as a novel field of medicine refers to the prescription of specific therapeutics procedure for an individual. This approach has established based on pharmacogenetic and pharmacogenomic information and data. The terms precision and personalized medicines are sometimes applied interchangeably. However, there has been a shift from "personalized medicine" towards "precision medicine". Although personalized medicine emerged from pharmacogenetics, nowadays it covers many fields of healthcare. Accordingly, regenerative medicine and cellular therapy as the new fields of medicine use cell-based products in order to develop personalized treatments. Different sources of stem cells including mesenchymal stem cells, embryonic stem cells and induced pluripotent stem cells (iPSCs) have been considered in targeted therapies which could give many advantages. iPSCs as the novel and individual pluripotent stem cells have been introduced as the appropriate candidates for personalized cell therapies. Cellular therapies can provide a personalized approach. Because of person-to-person and population differences in the result of stem cell therapy, individualized cellular therapy must be adjusted according to the patient specific profile, in order to achieve best therapeutic results and outcomes. Several factors should be considered to achieve personalized stem cells therapy such as, recipient factors, donor factors, and the overall body environment in which the stem cells could be active and functional. In addition to these factors, the source of stem cells must be carefully chosen based on functional and physical criteria that lead to optimal outcomes.

  12. Thermally regenerative fuel cells

    Science.gov (United States)

    Ludwig, F. A.; Kindler, A.; McHardy, J.

    1991-10-01

    The three phase project was undertaken to investigate solventless ionic liquids as possible working fluids for a new type of thermally regenerative fuel cell (TRFC). The heart of the new device, invented at Hughes Aircraft Company in 1983, is an electrochemical concentration cell where acid and base streams react to produce electrical energy. Thermal energy is then used to decompose the resulting salts and regenerate the cell reactants. In principle, a TRFC can be matched to any source of thermal energy simply by selecting working fluids with the appropriate regeneration temperature. However, aqueous working fluids (the focus of previous studies) impose limitations on both the operating temperatures and the achievable energy densities. It was the need to overcome these limitations that prompted the present investigation. Specific aims were to identify possible working fluids for TRFC systems with both low and high regeneration temperatures. A major advantage of our aqueous-fluid TRFC systems has been the ability to use hydrogen electrodes. The low activation and mass transfer losses of these electrodes contribute substantially to overall system efficiency.

  13. The Pharmacology of Regenerative Medicine

    Science.gov (United States)

    Saul, Justin M.; Furth, Mark E.; Andersson, Karl-Erik

    2013-01-01

    Regenerative medicine is a rapidly evolving multidisciplinary, translational research enterprise whose explicit purpose is to advance technologies for the repair and replacement of damaged cells, tissues, and organs. Scientific progress in the field has been steady and expectations for its robust clinical application continue to rise. The major thesis of this review is that the pharmacological sciences will contribute critically to the accelerated translational progress and clinical utility of regenerative medicine technologies. In 2007, we coined the phrase “regenerative pharmacology” to describe the enormous possibilities that could occur at the interface between pharmacology, regenerative medicine, and tissue engineering. The operational definition of regenerative pharmacology is “the application of pharmacological sciences to accelerate, optimize, and characterize (either in vitro or in vivo) the development, maturation, and function of bioengineered and regenerating tissues.” As such, regenerative pharmacology seeks to cure disease through restoration of tissue/organ function. This strategy is distinct from standard pharmacotherapy, which is often limited to the amelioration of symptoms. Our goal here is to get pharmacologists more involved in this field of research by exposing them to the tools, opportunities, challenges, and interdisciplinary expertise that will be required to ensure awareness and galvanize involvement. To this end, we illustrate ways in which the pharmacological sciences can drive future innovations in regenerative medicine and tissue engineering and thus help to revolutionize the discovery of curative therapeutics. Hopefully, the broad foundational knowledge provided herein will spark sustained conversations among experts in diverse fields of scientific research to the benefit of all. PMID:23818131

  14. Monitoring and Analyzing of Vibration Signal from Grinding of Precision Balls Based on Virtual Instrument%基于虚拟仪器的精密球研磨加工的振动信号检测与分析

    Institute of Scientific and Technical Information of China (English)

    夏其表; 王洁; 许凤亚

    2011-01-01

    振动信号是反映精密球体研磨状态的重要途径.利用加速度计传感器、数据采集卡和LabVIEW,设计一套基于虚拟仪器的振动信号检测设备,对精密球在研磨加工过程中的振动信号进行测试,从时域、频域等多个角度进行分析.结果表明:利用精密球体研磨加工的振动信号能有效地监控整个研磨过程,实时反映球体研磨的状态和精度.%Vibration signal is one important approach which can reflect the state of ball lapping. The grinding vibration signals in the process of precision balls grinding were tested by one detection device built by data acquisition kard, accelerometer sensor and virtual instrument software. These signals were analyzed from time domain and frequency domain. The results indicate that grinding vibration signals can be used to monitor the process of ball grinding. The grinding state and precision of precision balls can be reflected realtime.

  15. Regenerative Endodontics for Adult Patients.

    Science.gov (United States)

    He, Ling; Kim, Sahng G; Gong, Qimei; Zhong, Juan; Wang, Sainan; Zhou, Xuedong; Ye, Ling; Ling, Junqi; Mao, Jeremy J

    2017-09-01

    The goal of endodontics is to save teeth. Since inception, endodontic treatments are performed to obturate disinfected root canals with inert materials such as gutta-percha. Although teeth can be saved after successful endodontic treatments, they are devitalized and therefore susceptible to reinfections and fractures. The American Association of Endodontists (AAE) has made a tremendous effort to revitalize disinfected immature permanent teeth in children and adolescents with diagnoses including pulp necrosis or apical periodontitis. The American Dental Association (ADA) in 2011 issued several clinical codes for regenerative endodontic procedures or apical revascularization in necrotic immature permanent teeth in children and adolescents. These AAE and ADA initiatives have stimulated robust interest in devising a multitude of tissue engineering approaches for dental pulp and dentin regeneration. Can the concept of regenerative endodontics be extended to revitalize mature permanent teeth with diagnoses including irreversible pulpitis and/or pulp necrosis in adults? The present article was written not only to summarize emerging findings to revitalize mature permanent teeth in adult patients but also to identify challenges and strategies that focus on realizing the goal of regenerative endodontics in adults. We further present clinical cases and describe the biological basis of potential regenerative endodontic procedures in adults. This article explores the frequently asked question if regenerative endodontic therapies should be developed for dental pulp and/or dentin regeneration in adults, who consist of the great majority of endodontic patients. Copyright © 2017 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  16. Regenerative strategies for craniofacial disorders

    Directory of Open Access Journals (Sweden)

    Catharine Bradford Garland

    2012-12-01

    Full Text Available Craniofacial disorders present markedly complicated problems in reconstruction because of the complex interactions of the multiple, simultaneously affected tissues. Regenerative medicine holds promise for new strategies to improve treatment of these disorders. This review addresses current areas of unmet need in craniofacial reconstruction and emphasizes how craniofacial tissues differ from their analogs elsewhere in the body. We present a problem-based approach to illustrate current treatment strategies for various craniofacial disorders, to highlight areas of need, and to suggest regenerative strategies for craniofacial bone, fat, muscle, nerve, and skin. For some tissues, current approaches offer excellent reconstructive solutions using autologous tissue or prosthetic materials. Thus, new regenerative approaches would need to offer major advantages in order to be adopted. In other tissues, the unmet need is great, and we suggest the greatest regenerative need is for muscle, skin, and nerve. The advent of composite facial tissue transplantation and the development of regenerative medicine are each likely to add important new paradigms to our treatment of craniofacial disorders.

  17. Constructing Periodic Phase Space Orbits from ab Initio Molecular Dynamics Trajectories to Analyze Vibrational Spectra: Case Study of the Zundel (H5O2(+)) Cation.

    Science.gov (United States)

    Dietrick, Scott M; Iyengar, Srinivasan S

    2012-12-11

    A method of analysis is introduced to probe the spectral features obtained from ab initio molecular dynamics simulations. Here, the instantaneous mass-weighted velocities are projected onto irreducible representations constructed from discrete time translation groups comprising operations that invoke the time-domain symmetries (or periodic phase space orbits) reflected in the spectra. The projected velocities are decomposed using singular value decomposition (SVD) to construct a set of "modes" pertaining to a given frequency domain. These modes now include all anharmonicities, as sampled during the dynamics simulations. In this approach, the underlying motions are probed in a manner invariant with respect to coordinate transformations, operations being performed along the time axis rather than coordinate axes, making the analysis independent of choice of reference frame. The method is used to probe the underlying motions responsible for the doublet at ∼1000 cm(-1) in the vibrational spectrum of the H5O2(+), Zundel cation. The associated analysis results are confirmed by projecting the Fourier transformed velocities onto the harmonic normal mode coordinates and a set of mass-weighted, symmetrized Jacobi coordinates. It is found that the two peaks of the doublet are described and differentiated by their respective contributions from the proton transfer, water-water stretch, and water wag coordinates, as these are defined. Temperature dependent effects are also briefly noted.

  18. Analyzing the Effect of Capillary Force on Vibrational Performance of the Cantilever of an Atomic Force Microscope in Tapping Mode with Double Piezoelectric Layers in an Air Environment.

    Science.gov (United States)

    Nahavandi, Amir; Korayem, Moharam Habibnejad

    2015-10-01

    The aim of this paper is to determine the effects of forces exerted on the cantilever probe tip of an atomic force microscope (AFM). These forces vary according to the separation distance between the probe tip and the surface of the sample being examined. Hence, at a distance away from the surface (farther than d(on)), these forces have an attractive nature and are of Van der Waals type, and when the probe tip is situated in the range of a₀≤ d(ts) ≤ d(on), the capillary force is added to the Van der Waals force. At a distance of d(ts) ≤ a₀, the Van der Waals and capillary forces remain constant at intermolecular distances, and the contact repulsive force repels the probe tip from the surface of sample. The capillary force emerges due to the contact of thin water films with a thickness of h(c) which have accumulated on the sample and probe. Under environmental conditions a layer of water or hydrocarbon often forms between the probe tip and sample. The capillary meniscus can grow until the rate of evaporation equals the rate of condensation. For each of the above forces, different models are presented. The smoothness or roughness of the surfaces and the geometry of the cantilever tip have a significant effect on the modeling of forces applied on the probe tip. Van der Waals and the repulsive forces are considered to be the same in all the simulations, and only the capillary force is altered in order to evaluate the role of this force in the AFM-based modeling. Therefore, in view of the remarkable advantages of the piezoelectric microcantilever and also the extensive applications of the tapping mode, we investigate vibrational motion of the piezoelectric microcantilever in the tapping mode. The cantilever mentioned is entirely covered by two piezoelectric layers that carry out both the actuation of the probe tip and the measuringof its position.

  19. Regenerative Endodontics by Cell Homing.

    Science.gov (United States)

    He, Ling; Zhong, Juan; Gong, Qimei; Cheng, Bin; Kim, Sahng G; Ling, Junqi; Mao, Jeremy J

    2017-01-01

    Apical revascularization (AR) and platelet-rich plasma have been used to restore dental pulp vitality in infected immature permanent teeth. Two regenerative therapies are cell transplantation and cell homing. This article updates and benchmarks these therapies with cell homing. A case report concluded that AR increased root length; however, quantitative and statistical assessments disproved this. Regenerative endodontic therapies require prospective clinical trials demonstrating safety and efficacy. These therapies are intrinsically susceptible to procedural and patient variations. Cell homing uses novel molecules that drive therapeutic efficacy, and may be less sensitive to procedural and patient variations. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Optical techniques in regenerative medicine

    CERN Document Server

    Morgan, Stephen P

    2013-01-01

    In regenerative medicine, tissue engineers largely rely on destructive and time-consuming techniques that do not allow in situ and spatial monitoring of tissue growth. Furthermore, once the therapy is implanted in the patient, clinicians are often unable to monitor what is happening in the body. To tackle these barriers, optical techniques have been developed to image and characterize many tissue properties, fabricate tissue engineering scaffolds, and characterize the properties of the scaffolds. Optical Techniques in Regenerative Medicine illustrates how to use optical imaging techniques and

  1. Regeneratively Cooled Porous Media Jacket

    Science.gov (United States)

    Mungas, Greg (Inventor); Fisher, David J. (Inventor); London, Adam Pollok (Inventor); Fryer, Jack Merrill (Inventor)

    2013-01-01

    The fluid and heat transfer theory for regenerative cooling of a rocket combustion chamber with a porous media coolant jacket is presented. This model is used to design a regeneratively cooled rocket or other high temperature engine cooling jacket. Cooling jackets comprising impermeable inner and outer walls, and porous media channels are disclosed. Also disclosed are porous media coolant jackets with additional structures designed to transfer heat directly from the inner wall to the outer wall, and structures designed to direct movement of the coolant fluid from the inner wall to the outer wall. Methods of making such jackets are also disclosed.

  2. Vibration of hydraulic machinery

    CERN Document Server

    Wu, Yulin; Liu, Shuhong; Dou, Hua-Shu; Qian, Zhongdong

    2013-01-01

    Vibration of Hydraulic Machinery deals with the vibration problem which has significant influence on the safety and reliable operation of hydraulic machinery. It provides new achievements and the latest developments in these areas, even in the basic areas of this subject. The present book covers the fundamentals of mechanical vibration and rotordynamics as well as their main numerical models and analysis methods for the vibration prediction. The mechanical and hydraulic excitations to the vibration are analyzed, and the pressure fluctuations induced by the unsteady turbulent flow is predicted in order to obtain the unsteady loads. This book also discusses the loads, constraint conditions and the elastic and damping characters of the mechanical system, the structure dynamic analysis, the rotor dynamic analysis and the system instability of hydraulic machines, including the illustration of monitoring system for the instability and the vibration in hydraulic units. All the problems are necessary for vibration pr...

  3. Regenerative Perspective in Modern Dentistry

    Directory of Open Access Journals (Sweden)

    Mihnea Ioan Nicolescu

    2016-04-01

    Full Text Available This review aims to trace the contour lines of regenerative dentistry, to offer an introductory overview on this emerging field to both dental students and practitioners. The crystallized depiction of the concept is a translational approach, connecting dental academics to scientific research and clinical utility. Therefore, this review begins by presenting the general features of regenerative medicine, and then gradually introduces the specific aspects of major dental subdomains, highlighting the progress achieved during the last years by scientific research and, in some cases, which has already been translated into clinical results. The distinct characteristics of stem cells and their microenvironment, together with their diversity in the oral cavity, are put into the context of research and clinical use. Examples of regenerative studies regarding endodontic and periodontal compartments, as well as hard (alveolar bone and soft (salivary glands related tissues, are presented to make the reader further acquainted with the topic. Instead of providing a conclusion, we will emphasize the importance for all dental community members, from young students to experienced dentists, of an early awareness rising regarding biomedical research progress in general and regenerative dentistry in particular.

  4. Biomimetic microenvironments for regenerative endodontics.

    Science.gov (United States)

    Kaushik, Sagar N; Kim, Bogeun; Walma, Alexander M Cruz; Choi, Sung Chul; Wu, Hui; Mao, Jeremy J; Jun, Ho-Wook; Cheon, Kyounga

    2016-01-01

    Regenerative endodontics has been proposed to replace damaged and underdeveloped tooth structures with normal pulp-dentin tissue by providing a natural extracellular matrix (ECM) mimicking environment; stem cells, signaling molecules, and scaffolds. In addition, clinical success of the regenerative endodontic treatments can be evidenced by absence of signs and symptoms; no bony pathology, a disinfected pulp, and the maturation of root dentin in length and thickness. In spite of the various approaches of regenerative endodontics, there are several major challenges that remain to be improved: a) the endodontic root canal is a strong harbor of the endodontic bacterial biofilm and the fundamental etiologic factors of recurrent endodontic diseases, (b) tooth discolorations are caused by antibiotics and filling materials, (c) cervical root fractures are caused by endodontic medicaments, (d) pulp tissue is not vascularized nor innervated, and (e) the dentin matrix is not developed with adequate root thickness and length. Generally, current clinical protocols and recent studies have shown a limited success of the pulp-dentin tissue regeneration. Throughout the various approaches, the construction of biomimetic microenvironments of pulp-dentin tissue is a key concept of the tissue engineering based regenerative endodontics. The biomimetic microenvironments are composed of a synthetic nano-scaled polymeric fiber structure that mimics native pulp ECM and functions as a scaffold of the pulp-dentin tissue complex. They will provide a framework of the pulp ECM, can deliver selective bioactive molecules, and may recruit pluripotent stem cells from the vicinity of the pulp apex. The polymeric nanofibers are produced by methods of self-assembly, electrospinning, and phase separation. In order to be applied to biomedical use, the polymeric nanofibers require biocompatibility, stability, and biodegradability. Therefore, this review focuses on the development and application of the

  5. A 6-DOF vibration isolation system for hydraulic hybrid vehicles

    Science.gov (United States)

    Nguyen, The; Elahinia, Mohammad; Olson, Walter W.; Fontaine, Paul

    2006-03-01

    This paper presents the results of vibration isolation analysis for the pump/motor component of hydraulic hybrid vehicles (HHVs). The HHVs are designed to combine gasoline/diesel engine and hydraulic power in order to improve the fuel efficiency and reduce the pollution. Electric hybrid technology is being applied to passenger cars with small and medium engines to improve the fuel economy. However, for heavy duty vehicles such as large SUVs, trucks, and buses, which require more power, the hydraulic hybridization is a more efficient choice. In function, the hydraulic hybrid subsystem improves the fuel efficiency of the vehicle by recovering some of the energy that is otherwise wasted in friction brakes. Since the operation of the main component of HHVs involves with rotating parts and moving fluid, noise and vibration are an issue that affects both passengers (ride comfort) as well as surrounding people (drive-by noise). This study looks into the possibility of reducing the transmitted noise and vibration from the hydraulic subsystem to the vehicle's chassis by using magnetorheological (MR) fluid mounts. To this end, the hydraulic subsystem is modeled as a six degree of freedom (6-DOF) rigid body. A 6-DOF isolation system, consisting of five mounts connected to the pump/motor at five different locations, is modeled and simulated. The mounts are designed by combining regular elastomer components with MR fluids. In the simulation, the real loading and working conditions of the hydraulic subsystem are considered and the effects of both shock and vibration are analyzed. The transmissibility of the isolation system is monitored in a wide range of frequencies. The geometry of the isolation system is considered in order to sustain the weight of the hydraulic system without affecting the design of the chassis and the effectiveness of the vibration isolating ability. The simulation results shows reduction in the transmitted vibration force for different working cycles of

  6. Regenerative Endodontic Procedures: Clinical Outcomes.

    Science.gov (United States)

    Diogenes, Anibal; Ruparel, Nikita B

    2017-01-01

    Immature teeth are at risk for pulp necrosis, resulting in arrested root development and poor long-term prognosis. There is growing evidence that regenerative endodontic procedures promote desirable clinical outcomes. Despite significant advances in the field of regenerative endodontics and acceptable clinical outcomes, current evidence suggests that the tissues formed following currently used procedures do not completely recapitulate the former pulp-dentin complex. Further research is needed to identify prognostic factors and predictors of successful outcomes and to develop different treatment strategies to better predictably achieve all identified clinical outcomes, while favoring tissue formation that more closely resembles the pulp-dentin complex. Copyright © 2016. Published by Elsevier Inc.

  7. Regenerative endodontics: A way forward.

    Science.gov (United States)

    Diogenes, Anibal; Ruparel, Nikita B; Shiloah, Yoav; Hargreaves, Kenneth M

    2016-05-01

    Immature teeth are susceptible to infections due to trauma, anatomic anomalies, and caries. Traditional endodontic therapies for immature teeth, such as apexification procedures, promote resolution of the disease and prevent future infections. However, these procedures fail to promote continued root development, leaving teeth susceptible to fractures. Regenerative endodontic procedures (REPs) have evolved in the past decade, being incorporated into endodontic practice and becoming a viable treatment alternative for immature teeth. The authors have summarized the status of regenerative endodontics on the basis of the available published studies and provide insight into the different levels of clinical outcomes expected from these procedures. Substantial advances in regenerative endodontics are allowing a better understanding of a multitude of factors that govern stem cell-mediated regeneration and repair of the damaged pulp-dentin complex. REPs promote healing of apical periodontitis, continued radiographic root development, and, in certain cases, vitality responses. Despite the clinical success of these procedures, they appear to promote a guided endodontic repair process rather than a true regeneration of physiological-like tissue. Immature teeth with pulpal necrosis with otherwise poor prognosis can be treated with REPs. These procedures do not preclude the possibility of apexification procedures if attempts are unsuccessful. Therefore, REPs may be considered first treatment options for immature teeth with pulpal necrosis. Copyright © 2016 American Dental Association. Published by Elsevier Inc. All rights reserved.

  8. Regenerative endodontics: regeneration or repair?

    Science.gov (United States)

    Simon, Stéphane R J; Tomson, Phillip L; Berdal, Ariane

    2014-04-01

    Recent advances in biotechnology and translational research have made it possible to provide treatment modalities that protect the vital pulp, allow manipulation of reactionary and reparative dentinogenesis, and, more recently, permit revascularization of an infected root canal space. These approaches are referred to as regenerative procedures. The method currently used to determine the origin of the tissue secreted during the repair/regeneration process is largely based on the identification of cellular markers (usually proteins) left by cells that were responsible for this tissue production. The presence of these proteins in conjunction with other indicators of cellular behavior (especially biomineralization) and analysis of the structure of the newly generated tissue allow conclusions to be made of how it was formed. Thus far, it has not been possible to truly establish the biological mechanism controlling tertiary dentinogenesis. This article considers current therapeutic techniques to treat the dentin-pulp complex and contextualize them in terms of reparative and regenerative processes. Although it may be considered a semantic argument rather than a biological one, the definitions of regeneration and repair are explored to clarify our position in this era of regenerative endodontics. Copyright © 2014 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  9. Program ispitivanja i metodologija analize spektra vibracija brodske gasne turbine Proteus 52M/558 / The test programme and the methodology of analyzing the vibrations spectrum of a Proteus 52M/558 ship gas turbine

    Directory of Open Access Journals (Sweden)

    Predrag S. Dobratić

    2009-10-01

    Full Text Available The paper presents a programme for testing vibrations on a ship gas turbine, based on an analogy of testing and analysis of vibrations on aircraft and/or helicopter gas turbines. A particular attention is given to a choice of vibration parameters and to the analysis of the vibration spectrum as well as to the methods of estimation of criteria of vibration acceptability. The results of the measurement of the vibrations on a Proteus 52M/558 gas turbine installed on a RTOP-405 ship are shown. / U radu je prikazan program ispitivanja vibracija brodske gasne turbine, zasnovan na analogiji ispitivanja i analizi vibracija na avionskim i/ili helikopterskim gasnim turbinama. Posebna pažnja posvećena je izboru parametara vibracija, analizi spektra vibracija, kao i metodama procene kriterijuma prihvatljivosti vibracija. Na kraju rada prikazani su rezultati merenja vibracija na gasnoj turbini Proteus 52M/558 ugrađenoj na brodu RTOP-405.

  10. Regenerative Braking Algorithm for an ISG HEV Based on Regenerative Torque Optimization

    Institute of Scientific and Technical Information of China (English)

    XIAO Wen-yong; WANG Feng; ZHUO Bin

    2008-01-01

    A novel regenerative braking algorithm based on regenerative torque optimization with emulate engine compression braking (EECB) was proposed to make effective and maximum use of brake energy in order to improve fuel economy. The actual brake oil pressure of driving wheel which is reduced by the amount of the regenerative braking force is supplied from the electronic hydraulic brake system. Regenerative torque optimization maximizes the actual regenerative power recuperation by energy storage component, and EECB is a useful extended type of regenerative braking. The simulation results show that actual regenerative power recuperation for the novel regenerative braking algorithm is more than using conventional one, and life-span of brake disks is prolonged for the novel algorithm.

  11. A Study on Control Strategy of Regenerative Braking in the Hydraulic Hybrid Vehicle Based on ECE Regulations

    Directory of Open Access Journals (Sweden)

    Tao Liu

    2013-01-01

    Full Text Available This paper establishes a mathematic model of composite braking in the hydraulic hybrid vehicle and analyzes the constraint condition of parallel regenerative braking control algorithm. Based on regenerative braking system character and ECE (Economic Commission of Europe regulations, it introduces the control strategy of regenerative braking in parallel hydraulic hybrid vehicle (PHHV. Finally, the paper establishes the backward simulation model of the hydraulic hybrid vehicle in Matlab/simulink and makes a simulation analysis of the control strategy of regenerative braking. The results show that this strategy can equip the hydraulic hybrid vehicle with strong brake energy recovery power in typical urban drive state.

  12. Maximum Safety Regenerative Power Tracking for DC Traction Power Systems

    Directory of Open Access Journals (Sweden)

    Guifu Du

    2017-02-01

    Full Text Available Direct current (DC traction power systems are widely used in metro transport systems, with running rails usually being used as return conductors. When traction current flows through the running rails, a potential voltage known as “rail potential” is generated between the rails and ground. Currently, abnormal rises of rail potential exist in many railway lines during the operation of railway systems. Excessively high rail potentials pose a threat to human life and to devices connected to the rails. In this paper, the effect of regenerative power distribution on rail potential is analyzed. Maximum safety regenerative power tracking is proposed for the control of maximum absolute rail potential and energy consumption during the operation of DC traction power systems. The dwell time of multiple trains at each station and the trigger voltage of the regenerative energy absorbing device (READ are optimized based on an improved particle swarm optimization (PSO algorithm to manage the distribution of regenerative power. In this way, the maximum absolute rail potential and energy consumption of DC traction power systems can be reduced. The operation data of Guangzhou Metro Line 2 are used in the simulations, and the results show that the scheme can reduce the maximum absolute rail potential and energy consumption effectively and guarantee the safety in energy saving of DC traction power systems.

  13. Regenerative Engineering and Bionic Limbs

    Science.gov (United States)

    James, Roshan; Laurencin, Cato T.

    2015-01-01

    Amputations of the upper extremity are severely debilitating, current treatments support very basic limb movement, and patients undergo extensive physiotherapy and psychological counselling. There is no prosthesis that allows the amputees near-normal function. With increasing number of amputees due to injuries sustained in accidents, natural calamities and international conflicts, there is a growing requirement for novel strategies and new discoveries. Advances have been made in technological, material and in prosthesis integration where researchers are now exploring artificial prosthesis that integrate with the residual tissues and function based on signal impulses received from the residual nerves. Efforts are focused on challenging experts in different disciplines to integrate ideas and technologies to allow for the regeneration of injured tissues, recording on tissue signals and feed-back to facilitate responsive movements and gradations of muscle force. A fully functional replacement and regenerative or integrated prosthesis will rely on interface of biological process with robotic systems to allow individual control of movement such as at the elbow, forearm, digits and thumb in the upper extremity. Regenerative engineering focused on the regeneration of complex tissue and organ systems will be realized by the cross-fertilization of advances over the past thirty years in the fields of tissue engineering, nanotechnology, stem cell science, and developmental biology. The convergence of toolboxes crated within each discipline will allow interdisciplinary teams from engineering, science, and medicine to realize new strategies, mergers of disparate technologies, such as biophysics, smart bionics, and the healing power of the mind. Tackling the clinical challenges, interfacing the biological process with bionic technologies, engineering biological control of the electronic systems, and feed-back will be the important goals in regenerative engineering over the next

  14. Regenerative Engineering and Bionic Limbs.

    Science.gov (United States)

    James, Roshan; Laurencin, Cato T

    2015-03-01

    Amputations of the upper extremity are severely debilitating, current treatments support very basic limb movement, and patients undergo extensive physiotherapy and psychological counselling. There is no prosthesis that allows the amputees near-normal function. With increasing number of amputees due to injuries sustained in accidents, natural calamities and international conflicts, there is a growing requirement for novel strategies and new discoveries. Advances have been made in technological, material and in prosthesis integration where researchers are now exploring artificial prosthesis that integrate with the residual tissues and function based on signal impulses received from the residual nerves. Efforts are focused on challenging experts in different disciplines to integrate ideas and technologies to allow for the regeneration of injured tissues, recording on tissue signals and feed-back to facilitate responsive movements and gradations of muscle force. A fully functional replacement and regenerative or integrated prosthesis will rely on interface of biological process with robotic systems to allow individual control of movement such as at the elbow, forearm, digits and thumb in the upper extremity. Regenerative engineering focused on the regeneration of complex tissue and organ systems will be realized by the cross-fertilization of advances over the past thirty years in the fields of tissue engineering, nanotechnology, stem cell science, and developmental biology. The convergence of toolboxes crated within each discipline will allow interdisciplinary teams from engineering, science, and medicine to realize new strategies, mergers of disparate technologies, such as biophysics, smart bionics, and the healing power of the mind. Tackling the clinical challenges, interfacing the biological process with bionic technologies, engineering biological control of the electronic systems, and feed-back will be the important goals in regenerative engineering over the next

  15. Vibration energy harvesting from random force and motion excitations

    Science.gov (United States)

    Tang, Xiudong; Zuo, Lei

    2012-07-01

    A vibration energy harvester is typically composed of a spring-mass system with an electromagnetic or piezoelectric transducer connected in parallel with a spring. This configuration has been well studied and optimized for harmonic vibration sources. Recently, a dual-mass harvester, where two masses are connected in series by the energy transducer and a spring, has been proposed. The dual-mass vibration energy harvester is proved to be able to harvest more power and has a broader bandwidth than the single-mass configuration, when the parameters are optimized and the excitation is harmonic. In fact, some dual-mass vibration energy harvesters, such as regenerative vehicle suspensions and buildings with regenerative tuned mass dampers (TMDs), are subjected to random excitations. This paper is to investigate the dual-mass and single-mass vibration harvesters under random excitations using spectrum integration and the residue theorem. The output powers for these two types of vibration energy harvesters, when subjected to different random excitations, namely force, displacement, velocity and acceleration, are obtained analytically with closed-form expressions. It is also very interesting to find that the output power of the vibration energy harvesters under random excitations depends on only a few parameters in very simple and elegant forms. This paper also draws some important conclusions on regenerative vehicle suspensions and buildings with regenerative TMDs, which can be modeled as dual-mass vibration energy harvesters. It is found that, under white-noise random velocity excitation from road irregularity, the harvesting power from vehicle suspensions is proportional to the tire stiffness and road vertical excitation spectrum only. It is independent of the chassis mass, tire-wheel mass, suspension stiffness and damping coefficient. Under random wind force excitation, the power harvested from buildings with regenerative TMD will depends on the building mass only, not

  16. The imperative for regenerative agriculture.

    Science.gov (United States)

    Rhodes, Christopher J

    2017-03-01

    A review is made of the current state of agriculture, emphasising issues of soil erosion and dependence on fossil fuels, in regard to achieving food security for a relentlessly enlarging global population. Soil has been described as "the fragile, living skin of the Earth", and yet both its aliveness and fragility have all too often been ignored in the expansion of agriculture across the face of the globe. Since it is a pivotal component in a global nexus of soil-water-air-energy, how we treat the soil can impact massively on climate change - with either beneficial or detrimental consequences, depending on whether the soil is preserved or degraded. Regenerative agriculture has at its core the intention to improve the health of soil or to restore highly degraded soil, which symbiotically enhances the quality of water, vegetation and land-productivity. By using methods of regenerative agriculture, it is possible not only to increase the amount of soil organic carbon (SOC) in existing soils, but to build new soil. This has the effect of drawing down carbon from the atmosphere, while simultaneously improving soil structure and soil health, soil fertility and crop yields, water retention and aquifer recharge - thus ameliorating both flooding and drought, and also the erosion of further soil, since runoff is reduced. Since food production on a more local scale is found to preserve the soil and its quality, urban food production should be seen as a significant potential contributor to regenerative agriculture in the future, so long as the methods employed are themselves 'regenerative'. If localisation is to become a dominant strategy for dealing with a vastly reduced use of fossil fuels, and preserving soil quality - with increased food production in towns and cities - it will be necessary to incorporate integrated ('systems') design approaches such as permaculture and the circular economy (which minimise and repurpose 'waste') within the existing urban infrastructure. In

  17. Entropy Generation in Regenerative Systems

    Science.gov (United States)

    Kittel, Peter

    1995-01-01

    Heat exchange to the oscillating flows in regenerative coolers generates entropy. These flows are characterized by oscillating mass flows and oscillating temperatures. Heat is transferred between the flow and heat exchangers and regenerators. In the former case, there is a steady temperature difference between the flow and the heat exchangers. In the latter case, there is no mean temperature difference. In this paper a mathematical model of the entropy generated is developed for both cases. Estimates of the entropy generated by this process are given for oscillating flows in heat exchangers and in regenerators. The practical significance of this entropy is also discussed.

  18. 分析间歇雾化吸入联合振动排痰机治疗COPD的疗效%Intermittent inhalation therapy combined with vibration expectoration machine analyzes the effect of COPD patients

    Institute of Scientific and Technical Information of China (English)

    柏玉明; 崔平; 叶子

    2015-01-01

    ObjectiveTo analyze the intermittent inhalation therapy combined with vibration expectoration machine COPD patients results.MethodsRandomly selected in September 2011 July 2014 120 cases of COPD patients admitted to our hospital respiratory medicine as a research object, according to the digital method will be divided into a control group, 60 cases and 60 cases in treatment group and control group patients receiving traditional continued expectoration of inhalation joint vibration machine treatment, patients receiving intermittent inhalation joint vibration expectoration machine treatment, adverse reactions occurred two groups were compared, the expectoration effects and inhalation completion.ResultsThe patients treated with expectoration effect signiifcantly better than the control group of patients, the difference was signiifcant, with statistical signiifcance (P<0.05); patients treated with nebulized completion and poor atomization process occurs in the case of obvious reactions than the control group, a signiifcant difference between the groups, with statistical significance (P<0.05).ConclusionCombined intermittent inhalation therapy machine vibration expectoration COPD, expectoration signiifcant effect, reducing the incidence of adverse reactions, the patient was well tolerated, with a positive clinical value.%目的:分析间歇雾化吸入联合振动排痰机治疗慢性阻塞性肺疾病(COPD)的效果。方法随机选取2011年9月~2014年7月我院呼吸内科收治的120例COPD患者作为研究对象,按照数字法将其分为对照组60例和治疗组60例,对照组患者接受传统持续性雾化吸入联合振动排痰机治疗,治疗组患者接受间歇雾化吸入联合振动排痰机治疗,比较两组患者的不良反应发生情况、排痰效果以及雾化吸入完成情况。结果治疗组患者的排痰效果显著优于对照组患者,差异具有统计学意义(P<0.05);治疗组患者的雾化吸入完成

  19. Vibrations of rotating machinery

    CERN Document Server

    Matsushita, Osami; Kanki, Hiroshi; Kobayashi, Masao; Keogh, Patrick

    2017-01-01

    This book opens with an explanation of the vibrations of a single degree-of-freedom (dof) system for all beginners. Subsequently, vibration analysis of multi-dof systems is explained by modal analysis. Mode synthesis modeling is then introduced for system reduction, which aids understanding in a simplified manner of how complicated rotors behave. Rotor balancing techniques are offered for rigid and flexible rotors through several examples. Consideration of gyroscopic influences on the rotordynamics is then provided and vibration evaluation of a rotor-bearing system is emphasized in terms of forward and backward whirl rotor motions through eigenvalue (natural frequency and damping ratio) analysis. In addition to these rotordynamics concerning rotating shaft vibration measured in a stationary reference frame, blade vibrations are analyzed with Coriolis forces expressed in a rotating reference frame. Other phenomena that may be assessed in stationary and rotating reference frames include stability characteristic...

  20. Optimal performance of regenerative cryocoolers

    Science.gov (United States)

    de Boer, P. C. T.

    2011-02-01

    The key component of a regenerative cryocooler is its regenerative heat exchanger. This device is subject to losses due to imperfect heat transfer between the regenerator material and the gas, as well as due to viscous dissipation. The relative magnitudes of these losses can be characterized by the ratio of the Stanton number St to the Fanning friction factor f. Using available data for the ratio St/ f, results are developed for the optimal cooling rate and Carnot efficiency. The variations of pressure and temperature are taken to be sinusoidal in time, and to have small amplitudes. The results are applied to the case of the Stirling cryocooler, with flow being generated by pistons at both sides of the regenerator. The performance is found to be close to optimal at large ratio of the warm space volume to the regenerator void volume. The results are also applied to the Orifice Pulse Tube Refrigerator. In this case, optimal performance additionally requires a large ratio of the regenerator void volume to the cold space volume.

  1. Exergy analysis for combined regenerative Brayton and inverse Brayton cycles

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Zelong; Chen, Lingen; Sun, Fengrui [College of Naval Architecture and Power, Naval University of Engineering, Wuhan 430033 (China)

    2012-07-01

    This paper presents the study of exergy analysis of combined regenerative Brayton and inverse Brayton cycles. The analytical formulae of exergy loss and exergy efficiency are derived. The largest exergy loss location is determined. By taking the maximum exergy efficiency as the objective, the choice of bottom cycle pressure ratio is optimized by detailed numerical examples, and the corresponding optimal exergy efficiency is obtained. The influences of various parameters on the exergy efficiency and other performances are analyzed by numerical calculations.

  2. Changes in Regenerative Capacity through Lifespan

    Directory of Open Access Journals (Sweden)

    Maximina H. Yun

    2015-10-01

    Full Text Available Most organisms experience changes in regenerative abilities through their lifespan. During aging, numerous tissues exhibit a progressive decline in homeostasis and regeneration that results in tissue degeneration, malfunction and pathology. The mechanisms responsible for this decay are both cell intrinsic, such as cellular senescence, as well as cell-extrinsic, such as changes in the regenerative environment. Understanding how these mechanisms impact on regenerative processes is essential to devise therapeutic approaches to improve tissue regeneration and extend healthspan. This review offers an overview of how regenerative abilities change through lifespan in various organisms, the factors that underlie such changes and the avenues for therapeutic intervention. It focuses on established models of mammalian regeneration as well as on models in which regenerative abilities do not decline with age, as these can deliver valuable insights for our understanding of the interplay between regeneration and aging.

  3. Regenerative Electroless Etching of Silicon.

    Science.gov (United States)

    Kolasinski, Kurt W; Gimbar, Nathan J; Yu, Haibo; Aindow, Mark; Mäkilä, Ermei; Salonen, Jarno

    2017-01-09

    Regenerative electroless etching (ReEtching), described herein for the first time, is a method of producing nanostructured semiconductors in which an oxidant (Ox1 ) is used as a catalytic agent to facilitate the reaction between a semiconductor and a second oxidant (Ox2 ) that would be unreactive in the primary reaction. Ox2 is used to regenerate Ox1 , which is capable of initiating etching by injecting holes into the semiconductor valence band. Therefore, the extent of reaction is controlled by the amount of Ox2 added, and the rate of reaction is controlled by the injection rate of Ox2 . This general strategy is demonstrated specifically for the production of highly luminescent, nanocrystalline porous Si from the reaction of V2 O5 in HF(aq) as Ox1 and H2 O2 (aq) as Ox2 with Si powder and wafers.

  4. Regenerative Therapies for Diabetic Microangiopathy

    Directory of Open Access Journals (Sweden)

    Roberto Bassi

    2012-01-01

    Full Text Available Hyperglycaemia occurring in diabetes is responsible for accelerated arterial remodeling and atherosclerosis, affecting the macro- and the microcirculatory system. Vessel injury is mainly related to deregulation of glucose homeostasis and insulin/insulin-precursors production, generation of advanced glycation end-products, reduction in nitric oxide synthesis, and oxidative and reductive stress. It occurs both at extracellular level with increased calcium and matrix proteins deposition and at intracellular level, with abnormalities of intracellular pathways and increased cell death. Peripheral arterial disease, coronary heart disease, and ischemic stroke are the main causes of morbidity/mortality in diabetic patients representing a major clinical and economic issue. Pharmacological therapies, administration of growth factors, and stem cellular strategies are the most effective approaches and will be discussed in depth in this comprehensive review covering the regenerative therapies of diabetic microangiopathy.

  5. Towards personalized regenerative cell therapy

    DEFF Research Database (Denmark)

    Lin, Lin; Bolund, Lars; Luo, Yonglun

    2015-01-01

    Mesenchymal stem cells (MSCs) are adult stem cells with the capacity of self-renewal and multilineage differentiation, and can be isolated from several adult tissues. However, isolating MSCs from adult tissues for cell therapy is hampered by the invasive procedure, the rarity of the cells...... and their attenuated proliferation capacity when cultivated and expanded in vitro. Human MSCs derived from induced pluripotent stem cells (iPSC-MSCs) have now evolved as a promising alternative cell source for MSCs and regenerative medicine. Several groups, including ours, have reported successful derivation...... of functional iPSC-MSCs and applied these cells in MSC-based therapeutic testing. Still, the current experience and understanding of iPSC-MSCs with respect to production methods, safety and efficacy are primitive. In this review, we highlight the methodological progress in iPSC-MSC research, describing...

  6. Investigation of the Processing Parameters Impact on the Flexural Tool Vibrations While Drilling

    Directory of Open Access Journals (Sweden)

    I. I. Ivanov

    2015-01-01

    Full Text Available The paper considers an approach to analyze a dynamic stability of the drilling process in terms of tool flexibility. The proposed technique takes into consideration a regenerative effect leading to time delay in the dynamic system. This regenerative delay is the main source of arising dynamically unstable machining conditions. The paper describes a principle of emerging self-vibrations while cutting. It mentions the undesirable nature of transverse bending selfvibrations of tool, which cause a decreasing quality of the processed hole surface.The suggested approach consists in building a diagram of the drilling process stability for a tool model allowing only its flexural vibrations. The feature of the study is to describe tool dynamics using a finite element model based on the quadratic approximation of displacements for tool dynamics modeling. The assumption of an axial symmetry of drill geometry was discarded. The reduced model of tool was built taking into account two eigenvectors corresponding to tool bending. This model contains 2 degrees of freedom (DOF, which are, essentially, rotations of a drill tip. The technology of rigid multi-point constraints was used to connect those DOFs with solid finite element nodes. The system of delayed differential equations describing the reduced tool model dynamics was derived to estimate a dynamic stability of the drilling process. The Floquet theory is applied to build a stability diagram as a maximum multiplicator value versus a drill rotation rate. The presented diagram allows us to draw a conclusion that in the wide range of rotation frequencies transverse bending self- vibrations can be excited. The results obtained and the calculation technique may be used to choose the operation modes free from undesirable flexural self-vibrations of tool.The reported study was supported by RFBR within the framework of the research project ” mol_a”№ 14-08-31603 “Development of methods and algorithms for

  7. Improved Active Vibration Isolation Systems

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The control force, feedback gain, and actuator stroke of several active vibration isolation systems were analyzed based on a single-layer active vibration isolation system. The analysis shows that the feedback gain and actuator stroke cannot be selected independently and the active isolation system design must make a compromise between the feedback gain and actuator stroke. The performance of active isolation systems can be improved by the joint vibration reduction using an active vibration isolation system with an adaptive dynamic vibration absorber. The results show that the joint vibration reduction method can successfully avoid the compromise between the feedback gain and actuator stroke. The control force and the object vibration amplitude are also greatly reduced.

  8. Optimal thermoeconomic performance of an irreversible regenerative ferromagnetic Ericsson refrigeration cycle

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Zhichao [College of Physical Science and Technology, Xiamen University, Xiamen 361005 (China); Guo, Juncheng [College of Physics and Information Engineering, Fuzhou University, Fuzhou, 350116 China (China); Lin, Guoxing, E-mail: gxlin@xmu.edu.cn [College of Physical Science and Technology, Xiamen University, Xiamen 361005 (China); Chen, Jincan [College of Physical Science and Technology, Xiamen University, Xiamen 361005 (China)

    2016-07-01

    On the basis of the Langevin theory of classical statistical mechanics, the magnetization, entropy, and iso-field heat capacity of ferromagnetic materials are analyzed and their mathematical expressions are derived. An irreversible regenerative Ericsson refrigeration cycle by using a ferromagnetic material as the working substance is established, in which finite heat capacity rates of low and high temperature reservoirs, non-perfect regenerative heat of the refrigeration cycle, additional regenerative heat loss, etc. are taken into account. Based on the regenerative refrigeration cycle model, a thermoeconomic function is introduced as one objective function and optimized with respect to the temperatures of the working substance in the two iso-thermal processes. By means of numerical calculation, the effects of the effective factor of the heat exchangers in high/low temperature reservoir sides, efficiency of the regenerator, heat capacity rate of the low temperature reservoir, and applied magnetic field on the optimal thermoeconomic function as well as the corresponding cooling rate and coefficient of performance are revealed. The results obtained in this paper can provide some theoretical guidance for the optimal design of actual regenerative magnetic refrigerator cycle. - Highlights: • Thermodynamic performance of ferromagnetic material is analyzed. • An irreversible regenerative ferromagnetic Ericsson refrigeration cycle is set up. • The thermoeconomic objective function is introduced and optimized. • Impacts of the thermoeconomic and other parameters are discussed.

  9. Stem cell research and regenerative medicine in 2014: first year of regenerative medicine in Japan.

    Science.gov (United States)

    Okano, Hideyuki

    2014-09-15

    It is my great pleasure to announce that we were able to publish the Japan Issue in Stem Cells and Development, especially in this year 2014. This year, 2014, is said to be the First Year of Regenerative Medicine in Japan. This movement is likely to be based on the establishment of a new law system regarding regenerative medicine (an Act for Ensuring the Safety of Regenerative Medicine or the so-called Regenerative Medicine Law) and the partial revision of the Pharmaceutical Affairs Law (PAL). Both laws will come into effect in 2014 in this country. These new law systems are expected to have a great impact on the facilitation of R&D related to regenerative medicine and stem cell biology. In the present Japan Issue, some excellent stem cell research in this country will be introduced to celebrate the First Year of Regenerative Medicine in Japan.

  10. 3D Biomaterial Microarrays for Regenerative Medicine

    DEFF Research Database (Denmark)

    Gaharwar, Akhilesh K.; Arpanaei, Ayyoob; Andresen, Thomas Lars;

    2015-01-01

    Three dimensional (3D) biomaterial microarrays hold enormous promise for regenerative medicine because of their ability to accelerate the design and fabrication of biomimetic materials. Such tissue-like biomaterials can provide an appropriate microenvironment for stimulating and controlling stem...

  11. Applications of regenerative medicine in organ transplantation

    Directory of Open Access Journals (Sweden)

    Aditya Jain

    2015-01-01

    Full Text Available A worldwide shortage of organs for clinical implantation establishes the need to bring forward and test new technologies that will help in solving the problem. The concepts of regenerative medicine hold the potential for augmenting organ function or repairing damaged organ or allowing regeneration of deteriorated organs and tissue. Researchers are exploring possible regenerative medicine applications in organ transplantation so that coming together of the two fields can benefit each other. The present review discusses the strategies that are being implemented to regenerate or bio-engineer human organs for clinical purposes. It also highlights the limitations of the regenerative medicine that needs to be addressed to explore full potential of the field. A web-based research on MEDLINE was done using keywords "regenerative medicine," "tissue-engineering," "bio-engineered organs," "decellularized scaffold" and "three-dimensional printing." This review screened about 170 articles to get the desired knowledge update.

  12. Lattice Regenerative Cooling Methods (LRCM) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — ORBITEC proposes to develop and demonstrate a novel cooling concept called Lattice Regenerative Cooling Methods (LRCM) for future high thrust in-space propulsion...

  13. Regenerative Medicine for Neurological Disorders

    Directory of Open Access Journals (Sweden)

    Dong-Hyuk Park

    2010-01-01

    Full Text Available The annual meeting of the American Society for Neural Therapy and Repair (ASNTR has always introduced us to top-notch and up-to-date approaches for regenerative medicine related to neuroscience, ranging from stem cell–based therapy to novel drugs. The 16th ASNTR meeting focused on a variety of different topics, including the unknown pathogenesis or mechanisms of specific neurodegenerative diseases, stem cell biology, and development of novel alternative medicines or devices. Newly developed stem cells, such as amniotic epithelial stem cells and induced pluripotent stem cells, as well as well-known traditional stem cells, such as neural, embryonic, bone marrow mesenchymal, and human umbilical cord blood–derived stem cells, were reported. A number of commercialized stem cells were also covered at this meeting. Fetal neural tissues, such as ventral mesencephalon, striatum, and Schwann cells, were investigated for neurodegenerative diseases or spinal cord injury. A number of studies focused on novel methods for drug monitoring or graft tracking, and combination therapy with stem cells and medicine, such as cytokines or trophic factors. Finally, the National Institutes of Health guidelines for human stem cell research, clinical trials of commercialized stem cells without larger animal testing, and prohibition of medical tourism were big controversial issues that led to heated discussion.

  14. High power regenerative laser amplifier

    Science.gov (United States)

    Miller, J.L.; Hackel, L.A.; Dane, C.B.; Zapata, L.E.

    1994-02-08

    A regenerative amplifier design capable of operating at high energy per pulse, for instance, from 20-100 Joules, at moderate repetition rates, for instance from 5-20 Hertz is provided. The laser amplifier comprises a gain medium and source of pump energy coupled with the gain medium; a Pockels cell, which rotates an incident beam in response to application of a control signal; an optical relay system defining a first relay plane near the gain medium and a second relay plane near the rotator; and a plurality of reflectors configured to define an optical path through the gain medium, optical relay and Pockels cell, such that each transit of the optical path includes at least one pass through the gain medium and only one pass through the Pockels cell. An input coupler, and an output coupler are provided, implemented by a single polarizer. A control circuit coupled to the Pockels cell generates the control signal in timed relationship with the input pulse so that the input pulse is captured by the input coupler and proceeds through at least one transit of the optical path, and then the control signal is applied to cause rotation of the pulse to a polarization reflected by the polarizer, after which the captured pulse passes through the gain medium at least once more and is reflected out of the optical path by the polarizer before passing through the rotator again to provide an amplified pulse. 7 figures.

  15. Staged regenerative sorption heat pump

    Science.gov (United States)

    Jones, Jack A. (Inventor)

    1995-01-01

    A regenerative adsorbent heat pump process and system for cooling and heating a space. A sorbent is confined in a plurality of compressors of which at least four are first stage and at least four are second stage. The first stage operates over a first pressure region and the second stage over a second pressure region which is higher than the first. Sorbate from the first stage enters the second stage. The sorbate loop includes a condenser, expansion valve, evaporator and the compressors. A single sorbate loop can be employed for single-temperature-control such as air conditioning and heating. Two sorbate loops can be used for two-temperature-control as in a refrigerator and freezer. The evaporator temperatures control the freezer and refrigerator temperatures. Alternatively the refrigerator temperature can be cooled by the freezer with one sorbate loop. A heat transfer fluid is circulated in a closed loop which includes a radiator and the compressors. Low temperature heat is exhausted by the radiator. High temperature heat is added to the heat transfer fluid entering the compressors which are desorbing vapor. Heat is transferred from compressors which are sorbing vapor to the heat transfer fluid, and from the heat transfer fluid to the compressors which are desorbing vapor. Each compressor is subjected to the following phases, heating to its highest temperature, cooling down from its highest temperature, cooling to its lowest temperature, and warming up from its lowest temperature. The phases are repeated to complete a cycle and regenerate heat.

  16. A regenerative elastocaloric heat pump

    Science.gov (United States)

    Tušek, Jaka; Engelbrecht, Kurt; Eriksen, Dan; Dall'Olio, Stefano; Tušek, Janez; Pryds, Nini

    2016-10-01

    A large fraction of global energy use is for refrigeration and air-conditioning, which could be decarbonized if efficient renewable energy technologies could be found. Vapour-compression technology remains the most widely used system to move heat up the temperature scale after more than 100 years; however, caloric-based technologies (those using the magnetocaloric, electrocaloric, barocaloric or elastocaloric effect) have recently shown a significant potential as alternatives to replace this technology due to high efficiency and the use of green solid-state refrigerants. Here, we report a regenerative elastocaloric heat pump that exhibits a temperature span of 15.3 K on the water side with a corresponding specific heating power up to 800 W kg-1 and maximum COP (coefficient-of-performance) values of up to 7. The efficiency and specific heating power of this device exceeds those of other devices based on caloric effects. These results open up the possibility of using the elastocaloric effect in various cooling and heat-pumping applications.

  17. Recent considerations in regenerative endodontic treatment approaches

    Directory of Open Access Journals (Sweden)

    Hacer Aksel

    2014-09-01

    Conclusion: Although the regenerative treatment approaches have good clinical outcomes in the majority of case reports, the outcomes are unpredictable. Since the current clinical protocols for regenerative endodontics do not fully fulfill the triad of tissue engineering ((growth factors, scaffold and stem cells, further translational studies are required to achieve more pulp- and dentin-like tissue in the root canal system to achieve pulp regeneration.

  18. SEE SAW BASED REGENERATIVE POWER SYSTEM

    OpenAIRE

    Tribhuwan Singh; Shahzad Ali

    2016-01-01

    Research related to electrical vehicles is gaining importance due to the energy crisis. Using regenerative braking when braking, improves the efficiency of an electric vehicle as it recovers energy that could go to waste if mechanical brakes were used. A novel regenerative braking system for neighborhood electric vehicles was designed, prototyped and tested. The proposed system utilizes a seesaw system to capture energy whereas the conventional systems regenerate to the batteries. The user ha...

  19. Regenerative Medicine-Opportunities and Challenges

    Institute of Scientific and Technical Information of China (English)

    Zhengguo Wang

    2006-01-01

    In this paper, the definitions and contents of regenerative medicine, including tissue engineering, cell therapy, cytokine therapy and microecologic cure, were presented. And then, the prospects and difficulties for clinical application of these therapies were further mentioned. It indicated that the regenerative medicine came to a new era with full of opportunities and challenges. To face and seize this evanescent opportunity is worthy of detailed discussions.

  20. Current overview on challenges in regenerative endodontics

    Science.gov (United States)

    Bansal, Ramta; Jain, Aditya; Mittal, Sunandan

    2015-01-01

    Introduction: Regenerative endodontics provides hope of converting the non-vital tooth into vital once again. It focuses on substituting traumatized and pathological pulp with functional pulp tissue. Current regenerative procedures successfully produce root development but still fail to re-establish real pulp tissue and give unpredictable results. There are several drawbacks that need to be addressed to improve the quality and efficiency of the treatment. Aim: The aim of this review article is to discuss major priorities that ought to be dealt before applications of regenerative endodontics flourish the clinical practice. Materials and Methods: A web-based research on MEDLINE was done using filter terms Review, published in the last 10 years and Dental journals. Keywords used for research were “regenerative endodontics,” “dental stem cells,” “growth factor regeneration,” “scaffolds,” and “challenges in regeneration.” This review article screened about 150 articles and then the relevant information was compiled. Results: Inspite of the impressive growth in regenerative endodontic field, there are certain loopholes in the existing treatment protocols that might sometimes result in undesired and unpredictable outcomes. Conclusion: Considerable research and development efforts are required to improve and update existing regenerative endodontic strategies to make it an effective, safe, and biological mode to save teeth. PMID:25657518

  1. Current overview on challenges in regenerative endodontics.

    Science.gov (United States)

    Bansal, Ramta; Jain, Aditya; Mittal, Sunandan

    2015-01-01

    Regenerative endodontics provides hope of converting the non-vital tooth into vital once again. It focuses on substituting traumatized and pathological pulp with functional pulp tissue. Current regenerative procedures successfully produce root development but still fail to re-establish real pulp tissue and give unpredictable results. There are several drawbacks that need to be addressed to improve the quality and efficiency of the treatment. The aim of this review article is to discuss major priorities that ought to be dealt before applications of regenerative endodontics flourish the clinical practice. A web-based research on MEDLINE was done using filter terms Review, published in the last 10 years and Dental journals. Keywords used for research were "regenerative endodontics," "dental stem cells," "growth factor regeneration," "scaffolds," and "challenges in regeneration." This review article screened about 150 articles and then the relevant information was compiled. Inspite of the impressive growth in regenerative endodontic field, there are certain loopholes in the existing treatment protocols that might sometimes result in undesired and unpredictable outcomes. Considerable research and development efforts are required to improve and update existing regenerative endodontic strategies to make it an effective, safe, and biological mode to save teeth.

  2. Current overview on challenges in regenerative endodontics

    Directory of Open Access Journals (Sweden)

    Ramta Bansal

    2015-01-01

    Full Text Available Introduction: Regenerative endodontics provides hope of converting the non-vital tooth into vital once again. It focuses on substituting traumatized and pathological pulp with functional pulp tissue. Current regenerative procedures successfully produce root development but still fail to re-establish real pulp tissue and give unpredictable results. There are several drawbacks that need to be addressed to improve the quality and efficiency of the treatment. Aim: The aim of this review article is to discuss major priorities that ought to be dealt before applications of regenerative endodontics flourish the clinical practice. Materials and Methods: A web-based research on MEDLINE was done using filter terms Review, published in the last 10 years and Dental journals. Keywords used for research were "regenerative endodontics," "dental stem cells," "growth factor regeneration," "scaffolds," and "challenges in regeneration." This review article screened about 150 articles and then the relevant information was compiled. Results: Inspite of the impressive growth in regenerative endodontic field, there are certain loopholes in the existing treatment protocols that might sometimes result in undesired and unpredictable outcomes. Conclusion: Considerable research and development efforts are required to improve and update existing regenerative endodontic strategies to make it an effective, safe, and biological mode to save teeth.

  3. Regenerative Medicine Applications in Wound Care.

    Science.gov (United States)

    Ali Nilforoushzadeh, Mohammad; Mollapour Sisakht, Mahsa; Marcus Seifalian, Alexander; Amir Amirkhani, Mohammad; Reza Banafsheh, Hamid; Verdi, Javad; Sharifzad, Farzaneh; Taghiabadi, Ehsan

    2017-09-29

    During the last two decades, a number of studies have been published on different aspects of regenerative medicine in the field of dermatology. The following article aims at integrating all available information about regenerative dermatology, from the past to the present. In addition, we focused on most well-known application of regenerative medicine in dermatology field, wound healing, especially for burns and non-healing wounds based on available skin replacement in market. The present review focuses on providing an overview on available products in market and on-going clinical trials. These are valuable to get the picture of latest trends and also helpful for clinicians. In future, regenerative dermatology may encompass more effective and time-saving therapies for treating skin injuries and diseases. However, more clinical trials are required to establish standardized protocols and ascertain the safety, long-term effects, and efficacy of the novel therapeutic methods in regenerative dermatology. Despite several improvements in this field, extensive research is required for performing successful and precise clinical trials in future. Further improvements would enable the researchers to develop new products in this field. In this review, we have discussed the most recent breakthroughs in the field of regenerative dermatology. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  4. Waves & vibrations

    OpenAIRE

    Nicolas, Maxime

    2016-01-01

    Engineering school; This course is designed for students of Polytech Marseille, engineering school. It covers first the physics of vibration of the harmonic oscillator with damping and forcing, coupled oscillators. After a presentation of the wave equation, the vibration of strings, beams and membranes are studied.

  5. Research on cylindrical shell vibration reduction systems

    Institute of Scientific and Technical Information of China (English)

    XING Xiao-liang; WANG Min-qing

    2008-01-01

    Longitudinal and horizontal vibration must both be reduced in an effective vibration isolation system. We present a cylindrical shell vibration isolator as a dynamic system composed of four springs and dampers. Vibration is directly produced by the motion of machinery, and more is subsequently generated by harmonic frequencies within their structure. To test the effectiveness of our isolator, we first determined equations for the transmission of vibration from the machine to its cylindrical shell. Damping effects produced by the vibration parameters of our system are then analyzed.

  6. Regenerative Medicine and Stem Cells in Dermatology.

    Science.gov (United States)

    Moioli, Eduardo K; Bolotin, Diana; Alam, Murad

    2017-05-01

    Clinically relevant regenerative medicine is still in its early stages of development. Difficulties in regenerating large-scale and complex structures, the lack of safety data, and the paucity of clinical trials have slowed the process of technological advance. To familiarize the clinician with techniques available in the laboratory and experimental approaches being tested clinically. In addition, a layout is discussed for how dermatologists can lead the way in bringing regenerative medicine to clinical reality. This article reviews the relevant literature on regenerative medicine for dermatological applications and discusses findings and techniques in a clinically relevant context. Multiple cell-free and cell-based approaches for regenerating dermatologic tissues have been reported in the basic science and clinical literature. These are reviewed in the order of complexity. Incremental steps are needed to apply the principles of regenerative medicine to simple medical problems first. Such a stepwise approach would commence, for example, with creation of single-function tissues that could fill soft-tissue defects and proceed to the development of fully functional skin grafts. Likewise, cell-free approaches can build the foundation for the more technically demanding cell-based strategies that are likely necessary for achieving the ultimate goal of regenerative dermatology.

  7. Regenerative nanomedicine: current perspectives and future directions

    Directory of Open Access Journals (Sweden)

    Chaudhury K

    2014-09-01

    Full Text Available Koel Chaudhury, Vishu Kumar, Jayaprakash Kandasamy, Sourav RoyChoudhurySchool of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, IndiaAbstract: Nanotechnology has considerably accelerated the growth of regenerative medicine in recent years. Application of nanotechnology in regenerative medicine has revolutionized the designing of grafts and scaffolds which has resulted in new grafts/scaffold systems having significantly enhanced cellular and tissue regenerative properties. Since the cell–cell and cell-matrix interaction in biological systems takes place at the nanoscale level, the application of nanotechnology gives an edge in modifying the cellular function and/or matrix function in a more desired way to mimic the native tissue/organ. In this review, we focus on the nanotechnology-based recent advances and trends in regenerative medicine and discussed under individual organ systems including bone, cartilage, nerve, skin, teeth, myocardium, liver and eye. Recent studies that are related to the design of various types of nanostructured scaffolds and incorporation of nanomaterials into the matrices are reported. We have also documented reports where these materials and matrices have been compared for their better biocompatibility and efficacy in supporting the damaged tissue. In addition to the recent developments, future directions and possible challenges in translating the findings from bench to bedside are outlined.Keywords: regenerative medicine, nanomedicine, nanotechnology

  8. Exergy analysis for combined regenerative Brayton and inverse Brayton cycles

    Directory of Open Access Journals (Sweden)

    Zelong Zhang, Lingen Chen, Fengrui Sun

    2012-01-01

    Full Text Available This paper presents the study of exergy analysis of combined regenerative Brayton and inverse Brayton cycles. The analytical formulae of exergy loss and exergy efficiency are derived. The largest exergy loss location is determined. By taking the maximum exergy efficiency as the objective, the choice of bottom cycle pressure ratio is optimized by detailed numerical examples, and the corresponding optimal exergy efficiency is obtained. The influences of various parameters on the exergy efficiency and other performances are analyzed by numerical calculations.

  9. Good Vibrations

    OpenAIRE

    Panesar, Lucy

    2007-01-01

    Good Vibrations was a market research exercise conducted by Felicity (my alter-ego) and assistants to help develop marketing and packaging for an electro-therapeutic device (vibrator) used to treat hysteria and other female stress related disorders. It was a live art work commissioned by The Live Art Development Agency for East End Collaborations on 6th May 2007 and the South London Gallery for Bonkersfest on 2nd June 2007.

  10. Therapeutic potential of nanoceria in regenerative medicine

    Energy Technology Data Exchange (ETDEWEB)

    Das, Soumen [Univ. of Central Florida, Orlando, FL (United States); Chigurupati, Srinivasulu [U.S. Food and Drug Administration, Silver Spring, MD (United States); Dowding, Janet [Univ. of Central Florida, Orlando, FL (United States); Munusamy, Prabhakaran [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Baer, Donald R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); McGinnis, James F. [Univ. of Oklahoma Health Sciences Center, Oklahoma City, OK (United States); Mattson, Mark P. [National Inst. on Aging Intramural Research Program, Bethesda, MD (United States); Self, William [Univ. of Central Florida, Orlando, FL (United States); Seal, Sudipta [Univ. of Central Florida, Orlando, FL (United States)

    2014-11-01

    Tissue engineering and regenerative medicine aim to achieve functional restoration of tissue or cells damaged through disease, aging or trauma. Advancement of tissue engineering requires innovation in the field of 3D scaffolding, and functionalization with bioactive molecules. Nanotechnology offers advanced materials with patterned nano-morphologies for cell growth and different molecular substrates which can support cell survival and functions. Cerium oxide nanoparticles (nanoceria) can control intracellular as well as extracellular reactive oxygen and nitrogen species. Recent findings suggest that nanoceria can enhance long-term cell survival, enable cell migration and proliferation, and promote stem cell differentiation. Moreover, the self-regenerative property of nanoceria permits a small dose to remain catalytically active for extended time. This review summarizes the possibilities and applications of nanoceria in the field of tissue engineering and regenerative medicine.

  11. Vibration sensors

    Science.gov (United States)

    Gupta, Amita; Singh, Ranvir; Ahmad, Amir; Kumar, Mahesh

    2003-10-01

    Today, vibration sensors with low and medium sensitivities are in great demand. Their applications include robotics, navigation, machine vibration monitoring, isolation of precision equipment & activation of safety systems e.g. airbags in automobiles. Vibration sensors have been developed at SSPL, using silicon micromachining to sense vibrations in a system in the 30 - 200 Hz frequency band. The sensing element in the silicon vibration sensor is a seismic mass suspended by thin silicon hinges mounted on a metallized glass plate forming a parallel plate capacitor. The movement of the seismic mass along the vertical axis is monitored to sense vibrations. This is obtained by measuring the change in capacitance. The movable plate of the parallel plate capacitor is formed by a block connected to a surrounding frame by four cantilever beams located on sides or corners of the seismic mass. This element is fabricated by silicon micromachining. Several sensors in the chip sizes 1.6 cm x 1.6 cm, 1 cm x 1 cm and 0.7 cm x 0.7 cm have been fabricated. Work done on these sensors, techniques used in processing and silicon to glass bonding are presented in the paper. Performance evaluation of these sensors is also discussed.

  12. Vibrations and Stability

    DEFF Research Database (Denmark)

    Thomsen, Jon Juel

    dynamical phenomena that can be encountered in engineering and scientific practice. It progresses steadily from linear vibration theory over various levels of nonlinearity to bifurcation analysis, global dynamics and chaotic vibrations. It trains the student to analyze simple models, recognize nonlinear...... phenomena and work with advanced tools such as perturbation analysis and bifurcation analysis. Explaining theory in terms of relevant examples from real systems, this book is user-friendly and meets the increasing interest in non-linear dynamics in mechanical/structural engineering and applied mathematics...

  13. Regenerative potential of immature permanent teeth with necrotic pulps after different regenerative protocols.

    Science.gov (United States)

    Nagy, Mohamed M; Tawfik, Hosam E; Hashem, Ahmed Abdel Rahman; Abu-Seida, Ashraf M

    2014-02-01

    Regenerative endodontics is a promising alternative treatment for immature teeth with necrotic pulps. The present study was performed to assess the regenerative potential of young permanent immature teeth with necrotic pulp after the following treatment protocols: (1) a mineral trioxide aggregate (MTA) apical plug, (2) the regenerative endodontic protocol (blood clot scaffold), and (3) the regenerative endodontic protocol with a blood clot and an injectable scaffold impregnated with basic fibroblast growth factor. Immature necrotic permanent maxillary central incisors (n = 36) of patients 9-13 years old were divided into 3 groups according to the treatment protocol: the MTA group (MTA apical plug), the REG group (regenerative endodontic protocol [blood clot]), and the FGF group (regenerative endodontic protocol [blood clot + injectable scaffold]). Follow-up was done up to 18 months. Standardized radiographs were digitally evaluated for an increase in root length and thickness, a decrease in the apical diameter, and a change in periapical bone density. After a follow-up period of 18 months, most of the cases showed radiographic evidence of periapical healing. Groups 2 and 3 showed a progressive increase in root length and width and a decrease in apical diameter. The regenerative endodontic procedure allowed the continued development of roots in teeth with necrotic pulps. The use of artificial hydrogel scaffold and basic fibroblast growth factor was not essential for repair. Copyright © 2014 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  14. Platelet-rich plasma in regenerative medicine

    Directory of Open Access Journals (Sweden)

    Guhta Ra Hara and Thaha Basu

    2014-01-01

    Full Text Available Platelet-rich plasma (PRP contains at least seven growth factors including epidermal, plateletderived, transforming, vascular endothelial, fibroblast, insulin-like and keratinocyte growth factor. The therapeutic effect of PRP occurs because of the high concentration of these growth factors compared with those found in normal plasma. In recent years, PRP is widely used across many clinical fields, especially in regenerative medicine. This review aimed at presenting an overview of the applications of PRP in regenerative medicine. The mechanisms of PRP effects on healing are also stated in this review. [Biomed Res Ther 2014; 1(1.000: 25-31

  15. Energy-Regenerative Braking Control of Electric Vehicles Using Three-Phase Brushless Direct-Current Motors

    OpenAIRE

    Bo Long; Shin Teak Lim; Ji Hyoung Ryu; Kil To Chong

    2013-01-01

    Regenerative braking provides an effective way of extending the driving range of battery powered electric vehicles (EVs). This paper analyzes the equivalent power circuit and operation principles of an EV using regenerative braking control technology. During the braking period, the switching sequence of the power converter is controlled to inverse the output torque of the three-phase brushless direct-current (DC) motor, so that the braking energy can be returned to the battery. Compared with ...

  16. Advances in understanding tissue regenerative capacity and mechanisms in animals

    OpenAIRE

    Poss, Kenneth D.

    2010-01-01

    Questions about how and why tissue regeneration occurs capture the attention of countless biologists, biomedical engineers, and clinicians. Regenerative capacity differs greatly across organs and organisms, and a spectrum of model systems with different technical advantages and regenerative strategies are studied. Several key issues common to natural regenerative events are receiving new attention from improving models and approaches, including: the determination of regenerative capacity; the...

  17. Fuzzy Control Strategy of Battery Management for PHEV during Regenerative Braking

    Directory of Open Access Journals (Sweden)

    Zhumu Fu

    2014-01-01

    Full Text Available Based on analyzing the structure of Parallel Hybrid Electric Vehicle (PHEV and its operation during regenerative braking, a fuzzy control strategy of battery management is proposed. Firstly, the state of charging is estimated by establishing the mathematical relationship between open circuit voltage and the internal resistance model. Secondly, the fuzzy logic controller is designed in regenerative braking system. Finally, by modeling and simulation in ADVISOR, it is shown that the rate of energy recovery with the fuzzy control strategy is increased by 12.3, 18.3 and 7.6%, respectively in three different driving cycles, compared with the benchmark control strategy in the same driving cycles.

  18. Regenerative Burner System for Thermoelectric Power Sources.

    Science.gov (United States)

    1979-07-01

    wy aid id.nt lfy by block nsaib.r) • k’ all and (or • Thermoelectric ~t special Regenerative Burner Power Sources - 20. AS TRACT (Contlnu. on r...ELECTRIC POWER SOURCES C. Cuazgo~t , J. Angello, & A. Rerchshow.ki Power Source. Division US Army Electronic. Technology and Devices Laboratory

  19. Regenerative medicine: does Erythropoietin have a role?

    Science.gov (United States)

    Buemi, Michele; Lacquaniti, Antonio; Maricchiolo, Giulia; Bolignano, Davide; Campo, Susanna; Cernaro, Valeria; Sturiale, Alessio; Grasso, Giovanni; Buemi, Antoine; Allegra, Alessandro; Donato, Valentina; Genovese, Lucrezia

    2009-01-01

    Regenerative Medicine, a recent new medical domain, aims to develop new therapies through the stimulation of natural regenerative processes also in human beings. In this field, Erythropoietin (EPO) represents a significant subject of research. Several studies allow the assertion that EPO, in different concentrations, has protective effects mainly on the central nervous system, cardiovascular system and renal tissue. This action is carried out through one of few regenerative activities of human beings: angiogenesis. This mechanism, which involves endothelial stem cells and VEGF (Vascular Endothelial Growth Factor), has been experimentally demonstrated with Recombinant human erythropoietin (rHuEPO) and Darbepoetin, a long-acting EPO derivate. Furthermore, the demonstration of a cardiac production of EPO in Fugu rubripes and in Zebrafish has led cardiologists to "discover" Erythropoietin, postulating a hypothetical role in treatment of cardiovascular disease for this hormone. This is some of the experimental evidence which demonstrates that EPO can be in reason considered an important element of research of Regenerative Medicine and put in the network of drugs able to regenerate tissues and organs.

  20. Applications of regenerative medicine in organ transplantation

    Science.gov (United States)

    Jain, Aditya; Bansal, Ramta

    2015-01-01

    A worldwide shortage of organs for clinical implantation establishes the need to bring forward and test new technologies that will help in solving the problem. The concepts of regenerative medicine hold the potential for augmenting organ function or repairing damaged organ or allowing regeneration of deteriorated organs and tissue. Researchers are exploring possible regenerative medicine applications in organ transplantation so that coming together of the two fields can benefit each other. The present review discusses the strategies that are being implemented to regenerate or bio-engineer human organs for clinical purposes. It also highlights the limitations of the regenerative medicine that needs to be addressed to explore full potential of the field. A web-based research on MEDLINE was done using keywords “regenerative medicine,” “tissue-engineering,” “bio-engineered organs,” “decellularized scaffold” and “three-dimensional printing.” This review screened about 170 articles to get the desired knowledge update. PMID:26229352

  1. REGENERATIVE DESIGN PRACTICES IN NIGERIA: A CASE ...

    African Journals Online (AJOL)

    User

    2017-07-01

    Jul 1, 2017 ... of survey method of research, review of related literature, and ... A total of 207 questionnaires were retrieved and were analysed using descriptive statistics. ..... The regenerative approach to evaluate sustainability ..... Based on the analysis carried out in this research, the major findings are summarized as.

  2. Technical solutions to improve cardiac regenerative therapy

    NARCIS (Netherlands)

    van Slochteren, F.J.

    2014-01-01

    The therapeutic options for patients suffering from ischemic heart disease (IHD) are limited, and worldwide 23 million patients suffer from heart failure (HF). Therefore there is a strong need for alternative therapies for IHD. Since cardiac regenerative therapies have shown promising results in bas

  3. Optimal thermoeconomic performance of an irreversible regenerative ferromagnetic Ericsson refrigeration cycle

    Science.gov (United States)

    Xu, Zhichao; Guo, Juncheng; Lin, Guoxing; Chen, Jincan

    2016-07-01

    On the basis of the Langevin theory of classical statistical mechanics, the magnetization, entropy, and iso-field heat capacity of ferromagnetic materials are analyzed and their mathematical expressions are derived. An irreversible regenerative Ericsson refrigeration cycle by using a ferromagnetic material as the working substance is established, in which finite heat capacity rates of low and high temperature reservoirs, non-perfect regenerative heat of the refrigeration cycle, additional regenerative heat loss, etc. are taken into account. Based on the regenerative refrigeration cycle model, a thermoeconomic function is introduced as one objective function and optimized with respect to the temperatures of the working substance in the two iso-thermal processes. By means of numerical calculation, the effects of the effective factor of the heat exchangers in high/low temperature reservoir sides, efficiency of the regenerator, heat capacity rate of the low temperature reservoir, and applied magnetic field on the optimal thermoeconomic function as well as the corresponding cooling rate and coefficient of performance are revealed. The results obtained in this paper can provide some theoretical guidance for the optimal design of actual regenerative magnetic refrigerator cycle.

  4. Characteristics of Vibration Induced by Cavitation

    Institute of Scientific and Technical Information of China (English)

    WANG Guo-yu; TAO Lei; LIU Shu-yan; QIAN Jian-jun

    2005-01-01

    Cavitation-induced vibration characteristics and the relations between the vibration and cavitation are studied. Cavitation vibrations are measured around a model hollow-jet valve by an accelerometer under cavitating and non-cavitating conditions. The measurement data is analyzed by FFT method. The corresponding cavitating flow patterns are photographed by a high-speed camera with an xenon flash lamp. The frequency band of the vibration induced by cavitation is determined. To compare the vibration intensities under different cavitation conditions, a definition of vibration acceleration level is introduced based on power spectral density of the vibration. By the analysis of vibration, the definitions of characteristic cavitation number are suggested. According to these cavitation numbers, the cavitation process is divided into three stages, that is, incipient cavitation, subcavitation and supercavitation.

  5. Urban vibrations

    DEFF Research Database (Denmark)

    Morrison, Ann; Knudsen, L.; Andersen, Hans Jørgen

    2012-01-01

    In   this   paper   we   describe   a   field   study   conducted   with   a   wearable   vibration   belt   where   we   test   to   determine   the   vibration   intensity   sensitivity   ranges   on   a   large   diverse   group   of   participants   with   evenly   distributed  ages  and......   lab   studies   in   that   we   found   a   decreased   detection   rate   in   busy   environments.   Here   we   test   with   a   much   larger   sample   and   age   range,   and   contribute   with   the   first   vibration  sensitivity  testing  outside  the  lab  in  an  urban   public...

  6. Regenerative endodontic therapy: a data analysis of clinical protocols.

    Science.gov (United States)

    Kontakiotis, Evangelos G; Filippatos, Christos G; Tzanetakis, Giorgos N; Agrafioti, Anastasia

    2015-02-01

    The aim of the present study was to systematically analyze the protocols that have been used in regenerative endodontic therapy and to detect any variations in clinical procedures. An electronic search was executed in PubMed using appropriate Medical Subject Heading terms covering the period from January 1993 to May 2014. Additional publications from hand searching and the reference section of each relevant article enriched the article list. The relevance of each article was initially evaluated by scanning all titles and corresponding abstracts. The definite inclusion of each article in the study was determined by using specific criteria applied independently by 3 reviewers. Sixty relevant publications were finally included. The canal walls were not mechanically instrumented in 68% of the clinical articles. Sodium hypochlorite was included in 97% of the clinical studies either as the only irrigant or in combination with other irrigants. Antibiotic combination paste was used as the intracanal medicament in 80% of the clinical articles. Sodium hypochlorite, chlorhexidine, and EDTA were used in the final irrigation protocol in 75%, 4%, and 13% of the clinical studies, respectively. Neither the creation of a blood clot nor the use of platelet-rich plasma/platelet-rich fibrin was described in 13% of the clinical articles. Mineral trioxide aggregate was used as an intracanal coronal barrier in 85% of the relevant clinical studies. The variability of the clinical protocols applied during regenerative enododontic procedures is considerably high. A thorough analysis of regenerative protocols may constitute an additional source to provide useful clinical considerations for REPs. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  7. Exergy analyses of an endoreversible closed regenerative Brayton cycle CCHP plant

    Directory of Open Access Journals (Sweden)

    Bo Yang, Lingen Chen, Yanlin Ge, Fengrui Sun

    2014-01-01

    Full Text Available An endoreversible closed regenerative Brayton cycle CCHP (combined cooling, heating and power plant coupled to constant-temperature heat reservoirs is presented using finite time thermodynamics (FTT. The CCHP plant includes an endoreversible closed regenerative Brayton cycle, an endoreversible four-heat-reservoir absorption refrigerator and a heat recovery device of thermal consumer. The heat-resistance losses in the hot-, cold-, thermal consumer-, generator-, condenser-, evaporator- and absorber-side heat exchangers and regenerator are considered. The performance of the CCHP plant is studied from the exergetic perspective, and the analytical formulae about exergy output rate and exergy efficiency are derived. Through numerical calculations, the pressure ratio of regenerative Brayton cycle is optimized, the effects of heat conductance of regenerator and ratio of heat demanded by the thermal consumer to power output on dimensionless exergy output rate and exergy efficiency are analyzed.

  8. Vibrational spectroscopy

    Science.gov (United States)

    Umesh P. Agarwal; Rajai Atalla

    2010-01-01

    Vibrational spectroscopy is an important tool in modern chemistry. In the past two decades, thanks to significant improvements in instrumentation and the development of new interpretive tools, it has become increasingly important for studies of lignin. This chapter presents the three important instrumental methods-Raman spectroscopy, infrared (IR) spectroscopy, and...

  9. Vibrating minds

    CERN Document Server

    2009-01-01

    Ed Witten is one of the leading scientists in the field of string theory, the theory that describes elementary particles as vibrating strings. This week he leaves CERN after having spent a few months here on sabbatical. His wish is that the LHC will unveil supersymmetry.

  10. Analyzing Orientations

    Science.gov (United States)

    Ruggles, Clive L. N.

    Archaeoastronomical field survey typically involves the measurement of structural orientations (i.e., orientations along and between built structures) in relation to the visible landscape and particularly the surrounding horizon. This chapter focuses on the process of analyzing the astronomical potential of oriented structures, whether in the field or as a desktop appraisal, with the aim of establishing the archaeoastronomical "facts". It does not address questions of data selection (see instead Chap. 25, "Best Practice for Evaluating the Astronomical Significance of Archaeological Sites", 10.1007/978-1-4614-6141-8_25) or interpretation (see Chap. 24, "Nature and Analysis of Material Evidence Relevant to Archaeoastronomy", 10.1007/978-1-4614-6141-8_22). The main necessity is to determine the azimuth, horizon altitude, and declination in the direction "indicated" by any structural orientation. Normally, there are a range of possibilities, reflecting the various errors and uncertainties in estimating the intended (or, at least, the constructed) orientation, and in more formal approaches an attempt is made to assign a probability distribution extending over a spread of declinations. These probability distributions can then be cumulated in order to visualize and analyze the combined data from several orientations, so as to identify any consistent astronomical associations that can then be correlated with the declinations of particular astronomical objects or phenomena at any era in the past. The whole process raises various procedural and methodological issues and does not proceed in isolation from the consideration of corroborative data, which is essential in order to develop viable cultural interpretations.

  11. Energy regenerative suspension test for EEV and hybrid vehicle

    Science.gov (United States)

    Abdullah, M. A.; Jamil, J. F.; Muhammad, N. S.

    2015-12-01

    The world is demanding on the alternative fuel and reducing the fuel consumption of land transportation especially in the automotive industries. This paper emphasizes the development of the energy regenerative suspension system (EReSS) for energy efficient vehicle (EEV) or hybrid. The EReSS product is fabricated and tested on the laboratory and real vehicle. The test is conducted to test the function of the EReSS system on real vehicle. The test is done using the multimeter to record the reading of voltage produces by the EReSS system that is attached to the vehicle suspension system. The experiment starts by setting the parameters in the EReSS system which is the number of windings with a standard magnet. Road irregularity is one of the important parts of the experiment which is set to be various types of road condition and driving style. A domestic car model is selected for the EReSS test that the system can be installed. The test of the EReSS gives out the maximum output voltage of 5.6 V with 530 windings. Improvement on the material can increase the output voltage. The EReSS is function on the real vehicle by producing voltage by harvesting the kinetic energy from the suspension vibration.

  12. Regenerative medicine solutions in congenital diaphragmatic hernia.

    Science.gov (United States)

    De Coppi, Paolo; Deprest, Jan

    2017-06-01

    Congenital diaphragmatic hernia (CDH) remains a major challenge and associated mortality is still significant. Patients have benefited from current therapeutic options, but most severe cases are still associated to poor outcome. Regenerative medicine is emerging as a valid option in many diseases and clinical trials are currently happening for various conditions in children and adults. We report here the advancement in the field which will help both in the understanding of further CDH development and in offering new treatment options for the difficult situations such as repair of large diaphragmatic defects and lung hypoplasia. The authors believe that advancements in regenerative medicine may lead to increase of CDH patients׳ survival. Copyright © 2017. Published by Elsevier Inc.

  13. Regenerative Cooling for Liquid Rocket Engines

    Institute of Scientific and Technical Information of China (English)

    QiFeng

    1995-01-01

    Heat transfer in the thrust chamber is of great importance in the design of liquid propellant rocket engines.Regenerative cooling is and advanced method which can ensure not only the proper running but also higher performance of a rocket engine.The theoretical model is complicated,it relates to fluid bynamics,heat transfer,combustion.etc…,In this paper,a regenerative cooling model is presented.Effects such as radiation,heat transfer to environment,variable thermal properties and coking are included in the model.This model can be applied to all kinds of liquid propellant rocket engines as well as similar constructions.The modularized computer code is completed in the work.

  14. [Progress in stem cells and regenerative medicine].

    Science.gov (United States)

    Wang, Libin; Zhu, He; Hao, Jie; Zhou, Qi

    2015-06-01

    Stem cells have the ability to differentiate into all types of cells in the body and therefore have great application potential in regenerative medicine, in vitro disease modelling and drug screening. In recent years, stem cell technology has made great progress, and induced pluripotent stem cell technology revolutionizes the whole stem cell field. At the same time, stem cell research in our country has also achieved great progress and becomes an indispensable power in the worldwide stem cell research field. This review mainly focuses on the research progress in stem cells and regenerative medicine in our country since the advent of induced pluripotent stem cell technology, including induced pluripotent stem cells, transdifferentiation, haploid stem cells, and new gene editing tools.

  15. Regenerative cells for transplantation in hepatic failure.

    Science.gov (United States)

    Ishikawa, Tetsuya; Banas, Agnieszka; Teratani, Takumi; Iwaguro, Hideki; Ochiya, Takahiro

    2012-01-01

    Human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells have an enormous potential; however, their potential clinical application is being arrested due to various limitations such as teratoma formation followed by tumorigenesis, emergent usage, and the quality control of cells, as well as safety issues regarding long-term culture are also delaying their clinical application. In addition, human ES cells have two crucial issues: immunogenicity and ethical issues associated with their clinical application. The efficient generation of human iPS cells requires gene transfer, yet the mechanism underlying pluripotent stem cell induction has not yet been fully elucidated. Otherwise, although human adult regenerative cells including mesenchymal stem cells have a limited capacity for differentiation, they are nevertheless promising candidates for tissue regeneration in a clinical setting. This review highlights the use of regenerative cells for transplantation in hepatic failure.

  16. Regenerative endodontics: a state of the art.

    Science.gov (United States)

    Bansal, Rashmi; Bansal, Rajesh

    2011-01-01

    Scientific advances in the creation of restorative biomaterials, in vitro cell culture technology, tissue grafting, tissue engineering, molecular biology and the human genome project provide the basis for the introduction of new technologies into dentistry. Non-vital infected teeth have long been treated with root canal therapy (for mature root apex) and apexification (for immature root apex), or doomed to extraction. Although successful, current treatments fail to re-establish healthy pulp tissue in these teeth. But, what if the non-vital tooth could be made vital once again? That is the hope offered by regenerative endodontics, an emerging field focused on replacing traumatized and diseased pulp with functional pulp tissue. Restoration of vitality of non-vital tooth is based on tissue engineering and revascularization procedures. The purpose of this article is to review these biological procedures and the hurdles that must be overcome to develop regenerative endodontic procedures.

  17. Regenerative Endodontics: A Road Less Travelled

    Science.gov (United States)

    Bansal, Ramta; Mittal, Sunandan; Kumar, Tarun; Kaur, Dilpreet

    2014-01-01

    Although traditional approaches like root canal therapy and apexification procedures have been successful in treating diseased or infected root canals, but these modalities fail to re-establish healthy pulp tissue in treated teeth. Regeneration-based approaches aims to offer high levels of success by replacing diseased or necrotic pulp tissues with healthy pulp tissue to revitalize teeth. The applications of regenerative approaches in dental clinics have potential to dramatically improve patients’ quality of life. This review article offers a detailed overview of present regenerative endodontic approaches aiming to revitalize teeth and also outlines the problems to be dealt before this emerging field contributes to clinical treatment protocols. It conjointly covers the basic trilogy elements of tissue engineering. PMID:25478476

  18. Regenerative endodontics: A state of the art

    Directory of Open Access Journals (Sweden)

    Rashmi Bansal

    2011-01-01

    Full Text Available Scientific advances in the creation of restorative biomaterials, in vitro cell culture technology, tissue grafting, tissue engineering, molecular biology and the human genome project provide the basis for the introduction of new technologies into dentistry. Non-vital infected teeth have long been treated with root canal therapy (for mature root apex and apexification (for immature root apex, or doomed to extraction. Although successful, current treatments fail to re-establish healthy pulp tissue in these teeth. But, what if the non-vital tooth could be made vital once again? That is the hope offered by regenerative endodontics, an emerging field focused on replacing traumatized and diseased pulp with functional pulp tissue. Restoration of vitality of non-vital tooth is based on tissue engineering and revascularization procedures. The purpose of this article is to review these biological procedures and the hurdles that must be overcome to develop regenerative endodontic procedures.

  19. Regenerative endodontics: a road less travelled.

    Science.gov (United States)

    Bansal, Ramta; Jain, Aditya; Mittal, Sunandan; Kumar, Tarun; Kaur, Dilpreet

    2014-10-01

    Although traditional approaches like root canal therapy and apexification procedures have been successful in treating diseased or infected root canals, but these modalities fail to re-establish healthy pulp tissue in treated teeth. Regeneration-based approaches aims to offer high levels of success by replacing diseased or necrotic pulp tissues with healthy pulp tissue to revitalize teeth. The applications of regenerative approaches in dental clinics have potential to dramatically improve patients' quality of life. This review article offers a detailed overview of present regenerative endodontic approaches aiming to revitalize teeth and also outlines the problems to be dealt before this emerging field contributes to clinical treatment protocols. It conjointly covers the basic trilogy elements of tissue engineering.

  20. Regenerative Medicine from Protocol to Patient

    Directory of Open Access Journals (Sweden)

    Gustav Steinhoff

    2011-01-01

    Full Text Available The essentials of the upcoming and rapidly changing specialty of regenerative medicine, which has kindled high hopes among the clinical and scientific community as well as the society, are presented concisely in this book. Considering the multivariate sub-specialties within regenerative medicine, starting with cell biology and allied basic sciences through translational research to clinical application in various specialties of medicine, enormous efforts are mandatory to bring a comprehensive text book of this nature. The authors deserve kudos for this. This book comprehensively describes and reviews the current progress in stem cell research and regenerative medicine, in five main parts: (I Biology of Tissue Regeneration; (II Stem Cell Science and Technology; (III Tissue Engineering, Biomaterials and Nanotechnology; (IV Regenerative Therapies; and (V Regulation and Ethics. It fully covers all the major components in the field. Each chapter, written by the experts in the respective areas of work, throws light on the intricacies in detail, making this book immensely useful for students, clinicians and scientists interested in regenerative medicine. However, there is still scope for further refinement of some chapters. In Part II Stem Cell Science and Technology, three important stem cell types- muscle stem cells (satellite cells, stem cells from the skin and hair follicles, and stem cells from the gut epithelium-may be added as three individual chapters which probably the authors could consider for the next edition, as these cell types represent unique stem cells that have distinct properties and replenish specifically muscle, skin, hair, and gut epithelium respectively. In the chapter on cardiac stem cells, a table summarizing the properties of the four different types of cardiac stem cells described in the text may give readers more clear comparison of the pros and cons on these cells and know their properties better. The future direction

  1. Endometrial stem cells in regenerative medicine.

    Science.gov (United States)

    Verdi, Javad; Tan, Aaron; Shoae-Hassani, Alireza; Seifalian, Alexander M

    2014-01-01

    First described in 2004, endometrial stem cells (EnSCs) are adult stem cells isolated from the endometrial tissue. EnSCs comprise of a population of epithelial stem cells, mesenchymal stem cells, and side population stem cells. When secreted in the menstrual blood, they are termed menstrual stem cells or endometrial regenerative cells. Mounting evidence suggests that EnSCs can be utilized in regenerative medicine. EnSCs can be used as immuno-modulatory agents to attenuate inflammation, are implicated in angiogenesis and vascularization during tissue regeneration, and can also be reprogrammed into induced pluripotent stem cells. Furthermore, EnSCs can be used in tissue engineering applications and there are several clinical trials currently in place to ascertain the therapeutic potential of EnSCs. This review highlights the progress made in EnSC research, describing their mesodermal, ectodermal, and endodermal potentials both in vitro and in vivo.

  2. Induced pluripotent stem cells for regenerative medicine.

    Science.gov (United States)

    Hirschi, Karen K; Li, Song; Roy, Krishnendu

    2014-07-11

    With the discovery of induced pluripotent stem (iPS) cells, it is now possible to convert differentiated somatic cells into multipotent stem cells that have the capacity to generate all cell types of adult tissues. Thus, there is a wide variety of applications for this technology, including regenerative medicine, in vitro disease modeling, and drug screening/discovery. Although biological and biochemical techniques have been well established for cell reprogramming, bioengineering technologies offer novel tools for the reprogramming, expansion, isolation, and differentiation of iPS cells. In this article, we review these bioengineering approaches for the derivation and manipulation of iPS cells and focus on their relevance to regenerative medicine.

  3. Heat and Mass Transfer Enforcement of Vibrating Fluidized Bed

    Institute of Scientific and Technical Information of China (English)

    ChuZhide; YangJunhong; 等

    1994-01-01

    This paper briefly introduces the development of vibrating fluidized bed at home and abroad,elaborates the vibration properties of vibrating fluidized bed.the fluidizing velocity and pressure drop of the bed layer,it also deduces the non-steady state drying dynamic equations of vibrating fluidized bed,analyzes main factors which influence the drying rate and inquires into drying rules of fixed bed and vibrating fluidized bed.

  4. 直升机尾传动系统扭转振动建模与特性%Torsional vibration characteristics analyzing and modeling for helicopter tail drive system

    Institute of Scientific and Technical Information of China (English)

    朱自冰; 朱如鹏; 鲍和云

    2013-01-01

    The helicopter tail drive system was simplified to a series system with shaft section and equivalent disk.A equivalent dynamic analysis model with multiple degrees of freedom, in which the transmission error of meshing gear pair and meshing stiffness of tail-decelerated gear were included, was established for this simplified helicopter tail drive system.According to the torsional dynamics equation of helicopter tail drive system, the torsional vibration response of system was obtained, and the torsional vibration characteristics of the system with different torsional stiffness of the shaft and meshing stiffness of the gear were discussed.The following conclusions may be drawn from the analysis result.The torsional displacement of tail rotor is larger than the torsional displacement of driven gear of tail gearbox, namely the vibration response of output gear of tail gear box is larger than the input gear.The variation tendency is opposite of the torsional angle displacement between the equivalent disk connected to the horizontal shaft and oblique shaft respectively.The meshing stiffness has more influence on the system than the shaft torsional stiffness, it should be taken account into the modeling of helicopter tail drive system.%将直升机传动系统简化为轴段和当量圆盘的串联系统,建立了直升机尾传动系统扭转振动的等效多自由度动力学模型.模型中考虑了啮合齿轮对的综合啮合误差激励和尾减齿轮的啮合刚度,针对系统的扭转动力学方程,求得了系统的扭转振动响应,分析了直升机尾传动系统在轴的不同扭转刚度和齿轮的不同啮合刚度下的扭转振动的特性,结果表明:与尾斜轴相联的当量圆盘的扭转角位移始终比与水平轴相联的当量圆盘的扭转角位移的数值大,即与尾斜轴相联的尾减输出齿轮振动大于输入齿轮;当轴的扭转刚度变化时,水平轴相联的当量圆盘与尾斜轴相联的当量

  5. Culture Systems for Regenerative Kidney Therapy

    Science.gov (United States)

    2014-09-01

    regenerative medicine field, two key advances have demonstrated the feasibility of a cell -based therapy approach for renal replacement: i) Functional...kidney tissue from embryonic stem cells . This will allow us to generate patient- specific models of polycystic kidney disease, which affects many...the propagation of nephron progenitor cells derived either from embryonic mouse kidneys or human embryonic stem cells . We have used a combinatorial

  6. Nanostructured polymeric scaffolds for orthopaedic regenerative engineering.

    Science.gov (United States)

    Deng, Meng; James, Roshan; Laurencin, Cato T; Kumbar, Sangamesh G

    2012-03-01

    Successful regeneration necessitates the development of three-dimensional (3-D) tissue-inducing scaffolds that mimic the hierarchical architecture of native tissue extracellular matrix (ECM). Cells in nature recognize and interact with the surface topography they are exposed to via ECM proteins. The interaction of cells with nanotopographical features such as pores, ridges, groves, fibers, nodes, and their combinations has proven to be an important signaling modality in controlling cellular processes. Integrating nanotopographical cues is especially important in engineering complex tissues that have multiple cell types and require precisely defined cell-cell and cell-matrix interactions on the nanoscale. Thus, in a regenerative engineering approach, nanoscale materials/scaffolds play a paramount role in controlling cell fate and the consequent regenerative capacity. Advances in nanotechnology have generated a new toolbox for the fabrication of tissue-specific nanostructured scaffolds. For example, biodegradable polymers such as polyesters, polyphosphazenes, polymer blends and composites can be electrospun into ECM-mimicking matrices composed of nanofibers, which provide high surface area for cell attachment, growth, and differentiation. This review provides the fundamental guidelines for the design and development of nanostructured scaffolds for the regeneration of various tissue types in human upper and lower extremities such as skin, ligament, tendon, and bone. Examples focusing on the collective work of our laboratory in those areas are discussed to demonstrate the regenerative efficacy of this approach. Furthermore, preliminary strategies and significant challenges to integrate these individual tissues into one complex organ through regenerative engineering-based integrated graft systems are also discussed.

  7. Short wavelength regenerative amplifier free electron lasers

    OpenAIRE

    Dunning, D J; McNeil, B. W. J.; Thompson, N. R.

    2008-01-01

    In this paper we discuss extending the operating wavelength range of tunable Regenerative Amplifier FELs to shorter wavelengths than current design proposals, notably into the XUV regions of the spectrum and beyond where the reflectivity of broadband optics is very low. Simulation studies are presented which demonstrate the development of good temporal coherence in generic systems with a broadband radiation feedback of less than one part in ten thousand.

  8. Mesenchymal stem cells in regenerative rehabilitation.

    Science.gov (United States)

    Nurkovic, Jasmin; Dolicanin, Zana; Mustafic, Fahrudin; Mujanovic, Rifat; Memic, Mensur; Grbovic, Vesna; Skevin, Aleksandra Jurisic; Nurkovic, Selmina

    2016-06-01

    [Purpose] Regenerative medicine and rehabilitation contribute in many ways to a specific plan of care based on a patient's medical status. The intrinsic self-renewing, multipotent, regenerative, and immunosuppressive properties of mesenchymal stem cells offer great promise in the treatment of numerous autoimmune, degenerative, and graft-versus-host diseases, as well as tissue injuries. As such, mesenchymal stem cells represent a therapeutic fortune in regenerative medicine. The aim of this review is to discuss possibilities, limitations, and future clinical applications of mesenchymal stem cells. [Subjects and Methods] The authors have identified and discussed clinically and scientifically relevant articles from PubMed that have met the inclusion criteria. [Results] Direct treatment of muscle injuries, stroke, damaged peripheral nerves, and cartilage with mesenchymal stem cells has been demonstrated to be effective, with synergies seen between cellular and physical therapies. Over the past few years, several researchers, including us, have shown that there are certain limitations in the use of mesenchymal stem cells. Aging and spontaneous malignant transformation of mesenchymal stem cells significantly affect the functionality of these cells. [Conclusion] Definitive conclusions cannot be made by these studies because limited numbers of patients were included. Studies clarifying these results are expected in the near future.

  9. An animal model to study regenerative endodontics.

    Science.gov (United States)

    Torabinejad, Mahmoud; Corr, Robert; Buhrley, Matthew; Wright, Kenneth; Shabahang, Shahrokh

    2011-02-01

    A growing body of evidence is demonstrating the possibility for regeneration of tissues within the pulp space and continued root development in teeth with necrotic pulps and open apices. There are areas of research related to regenerative endodontics that need to be investigated in an animal model. The purpose of this study was to investigate ferret cuspid teeth as a model to investigate factors involved in regenerative endodontics. Six young male ferrets between the ages of 36-133 days were used in this investigation. Each animal was anesthetized and perfused with 10% buffered formalin. Block sections including the mandibular and maxillary cuspid teeth and their surrounding periapical tissues were obtained, radiographed, decalcified, sectioned, and stained with hematoxylin-eosin to determine various stages of apical closure in these teeth. The permanent mandibular and maxillary cuspid teeth with open apices erupted approximately 50 days after birth. Initial signs of closure of the apical foramen in these teeth were observed between 90-110 days. Complete apical closure was observed in the cuspid teeth when the animals were 133 days old. Based on the experiment, ferret cuspid teeth can be used to investigate various factors involved in regenerative endodontics that cannot be tested in human subjects. The most appropriate time to conduct the experiments would be when the ferrets are between the ages of 50 and 90 days. Copyright © 2011. Published by Elsevier Inc.

  10. Regenerative endodontics--Creating new horizons.

    Science.gov (United States)

    Dhillon, Harnoor; Kaushik, Mamta; Sharma, Roshni

    2016-05-01

    Trauma to the dental pulp, physical or microbiologic, can lead to inflammation of the pulp followed by necrosis. The current treatment modality for such cases is non-surgical root canal treatment. The damaged tissue is extirpated and the root canal system prepared. It is then obturated with an inert material such a gutta percha. In spite of advances in techniques and materials, 10%-15% of the cases may end in failure of treatment. Regenerative endodontics combines principles of endodontics, cell biology, and tissue engineering to provide an ideal treatment for inflamed and necrotic pulp. It utilizes mesenchymal stem cells, growth factors, and organ tissue culture to provide treatment. Potential treatment modalities include induction of blood clot for pulp revascularization, scaffold aided regeneration, and pulp implantation. Although in its infancy, successful treatment of damaged pulp tissue has been performed using principles of regenerative endodontics. This field is dynamic and exciting with the ability to shape the future of endodontics. This article highlights the fundamental concepts, protocol for treatment, and possible avenues for research in regenerative endodontics. © 2015 Wiley Periodicals, Inc.

  11. Design, Modeling, and Analysis of a Novel Hydraulic Energy-Regenerative Shock Absorber for Vehicle Suspension

    Directory of Open Access Journals (Sweden)

    Junyi Zou

    2017-01-01

    Full Text Available To reduce energy consumption or improve energy efficiency, the regenerative devices recently have drawn the public’s eyes. In this paper, a novel hydraulic energy-regenerative shock absorber (HERSA is developed for vehicle suspension to regenerate the vibration energy which is dissipated by conventional viscous dampers into heat waste. At first, the schematic of HERSA is presented and a mathematic model is developed to describe the characteristic of HERSA. Then the parametric sensitivity analysis of the vibration energy is expounded, and the ranking of their influences is k1≫m2>m1>k2≈cs. Besides, a parametric study of HERSA is adopted to research the influences of the key parameters on the characteristic of HERSA. Moreover, an optimization of HERSA is carried out to regenerate more power as far as possible without devitalizing the damping characteristic. To make the optimization results more close to the actual condition, the displacement data of the shock absorber in the road test is selected as the excitation in the optimization. The results show that the RMS of regenerated energy is up to 107.94 W under the actual excitation. Moreover it indicates that the HERSA can improve its performance through the damping control.

  12. Bi-Mix Antimicrobial Scaffolds for Regenerative Endodontics

    Science.gov (United States)

    Palasuk, Jadesada; Kamocki, Krzysztof; Hippenmeyer, Lauren; Platt, Jeffrey A.; Spolnik, Kenneth J.; Gregory, Richard L.; Bottino, Marco C.

    2014-01-01

    Introduction Eliminating and/or inhibiting bacterial growth within the root canal system have been shown to play a key role in the regenerative outcome. The aim of this study was to synthesize and determine in vitro both the antimicrobial effectiveness and cytocompatibility of bi-mix antibiotic-containing polydioxanone (PDS)-based polymer scaffolds. Methods Antibiotic-containing (metronidazole, MET and ciprofloxacin, CIP) polymer solutions (distinct antibiotic weight ratios) were spun into fibers as a potential mimic to the double antibiotic paste (DAP, a MET/CIP mixture). Fiber morphology, chemical characteristics, and tensile strength were evaluated by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and tensile testing, respectively. Antimicrobial efficacy was tested over time (aliquot collection) against Enterococcus faecalis (Ef), Porphyromonas gingivalis (Pg), and Fusobacterium nucleatum (Fn). Similarly, cytotoxicity was evaluated in human dental pulp stem cells (hDPSCs). Data were statistically analyzed (pendodontics. PMID:25201643

  13. Structure and Performance Analysis of Regenerative Electromagnetic Shock Absorber

    Directory of Open Access Journals (Sweden)

    Longxin Zhen

    2010-12-01

    Full Text Available This paper analyzed the structure and principle of a regenerative electromagnetic shock absorber in detail. The innovative shock absorber resembles linear generator in principle and can generate electric power through the relative reciprocating motion between coil assembly and permanent magnet assembly. At the same time, the damping can remove discomfort caused by road roughness. The regenerated electric power can be recovered through battery. Analysis of magnetic flux density of the permanent magnet array of the innovative shock absorber was performed using ANSYS software based on the structure parameters given in the paper,then the performance parameters of the shock absorber was determined . Analysis and calculation results prove the viability of this shock absorber.

  14. Localization theory of distributed fiber vibration sensor

    Institute of Scientific and Technical Information of China (English)

    Weimin Chen; Yuanyuan Xie; Peng Zhang; Lei Lin

    2009-01-01

    Based on Sagnac interferometer, a simple distributed optical fiber sensing system with sub-loop is pre-sented to monitor the vibration applied on the sensing fiber. By introducing a sub-loop, three output beams of interference with different delay time are gotten. Location of the vibration is analyzed through mathematical-physical equations. The vibration frequency, amplitude, and location are theoretically sim-ulated. The results agree well with the previous experiments.

  15. A Simulation Analysis on the Nonlinear Damping Characteristics of Electromagnetic Regenerative Suspension%电磁馈能悬架非线性阻尼特性仿真分析

    Institute of Scientific and Technical Information of China (English)

    刘松山; 王庆年; 王伟华

    2014-01-01

    A nonlinear damping characteristic for regenerative suspension based on the torque-speed char-acteristic of regenerative motor and traditional linear damping characteristic is proposed and the influences of opening speed and the initial speed of inadequate damping interval on vibration attenuation performance are analyzed. By an-alyzing the sprung mass acceleration response of single DOF linear suspension model, the effect of initial opening speed on vibration attenuation performance is obtained. For suppressing the peak acceleration response caused by entering constant damping interval, the relative speed transfer characteristic of linear suspension model is investiga-ted, with the adjustment coefficient for initial opening speed obtained. The results of simulation show that reasonable opening speed can greatly improve the transfer characteristic of regenerative damper, while the initial speed of inad-equate damping interval has no much effect on peak response for harmonic excitation.%提出了一种基于馈能电机转矩转速特性和传统线性阻尼特性的馈能悬架非线性阻尼特性,分析开启速度和阻尼不足区初始速度对减振性能的影响。通过对传统的单自由度线性悬架模型的簧载质量加速度响应分析,得出初始开启速度对其减振性能的影响。为了抑制进入恒阻尼区后导致的加速度响应峰值,对线性模型中的相对速度传递特性的研究,得出初始开启速度的调整系数。仿真结果表明,合理的开启速度能极大地改善馈能减振器的传递特性,阻尼不足区初始速度对谐波激励时的响应峰值影响并不大。

  16. Compressorless Gas Storage and Regenerative Hydrogen Purification Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Microwave regenerative sorption media gas storage/delivery techniques are proposed to address both compressed gas management and hydrogen purification requirements...

  17. Platelet rich fibrin - a novel acumen into regenerative endodontic therapy

    Directory of Open Access Journals (Sweden)

    Kavita Hotwani

    2014-02-01

    Full Text Available Research into regenerative dentistry has added impetus onto the field of molecular biology. It can be documented as a prototype shift in the therapeutic armamentarium for dental disease. Regenerative endodontic procedures are widely being added to the current armamentarium of pulp therapy procedures. The regenerative potential of platelets has been deliberated. A new family of platelet concentrates called the platelet rich fibrin (PRF has been recently used by several investigators and has shown application in diverse disciplines of dentistry. This paper is intended to add light on the various prospects of PRF and clinical insights to regenerative endodontic therapy.

  18. Platelet rich fibrin - a novel acumen into regenerative endodontic therapy.

    Science.gov (United States)

    Hotwani, Kavita; Sharma, Krishna

    2014-02-01

    Research into regenerative dentistry has added impetus onto the field of molecular biology. It can be documented as a prototype shift in the therapeutic armamentarium for dental disease. Regenerative endodontic procedures are widely being added to the current armamentarium of pulp therapy procedures. The regenerative potential of platelets has been deliberated. A new family of platelet concentrates called the platelet rich fibrin (PRF) has been recently used by several investigators and has shown application in diverse disciplines of dentistry. This paper is intended to add light on the various prospects of PRF and clinical insights to regenerative endodontic therapy.

  19. [Nodular regenerative hyperplasia associated with primary antiphospholipid syndrome].

    Science.gov (United States)

    Cadranel, J F; Demontis, R; Guettier, C; Bouraya, D; Dautreaux, M; Ghazali, A; Poux, J M; Coutarel, P; Devergie, B; Fievet, P

    1996-01-01

    Nodular regenerative hyperplasia of the liver is characterized by diffuse nodularity of the hepatic parenchyma without fibrotic septa. It may be related to venous or arterial obstruction in the portal tract. We report a case of primary antiphospholipid syndrome associated with nodular regenerative hyperplasia in a 45-year old woman. The patient had an ischemic stroke, associated with an acute arterial ischemia of the left leg. She had high titers of serum anticardiolipin antibodies. Nodular regenerative hyperplasia of the liver was histologically confirmed and was associated with anicteric cholestasis. This case provides additional evidence that a thrombotic mechanism may play a role in the pathogenesis of nodular regenerative hyperplasia of the liver.

  20. Regenerative Blower for EVA Suit Ventilation Fan

    Science.gov (United States)

    Izenson, Michael G.; Chen, Weibo; Paul, Heather L.

    2010-01-01

    Portable life support systems in future space suits will include a ventilation subsystem driven by a dedicated fan. This ventilation fan must meet challenging requirements for pressure rise, flow rate, efficiency, size, safety, and reliability. This paper describes research and development that showed the feasibility of a regenerative blower that is uniquely suited to meet these requirements. We proved feasibility through component tests, blower tests, and design analysis. Based on the requirements for the Constellation Space Suit Element (CSSE) Portable Life Support System (PLSS) ventilation fan, we designed the critical elements of the blower. We measured the effects of key design parameters on blower performance using separate effects tests, and used the results of these tests to design a regenerative blower that will meet the ventilation fan requirements. We assembled a proof-of-concept blower and measured its performance at sub-atmospheric pressures that simulate a PLSS ventilation loop environment. Head/flow performance and maximum efficiency point data were used to specify the design and operating conditions for the ventilation fan. We identified materials for the blower that will enhance safety for operation in a lunar environment, and produced a solid model that illustrates the final design. The proof-of-concept blower produced the flow rate and pressure rise needed for the CSSE ventilation subsystem while running at 5400 rpm, consuming only 9 W of electric power using a non-optimized, commercial motor and controller and inefficient bearings. Scaling the test results to a complete design shows that a lightweight, compact, reliable, and low power regenerative blower can meet the performance requirements for future space suit life support systems.

  1. Regenerative Electrode Interfaces for Neural Prostheses.

    Science.gov (United States)

    Thompson, Cort H; Zoratti, Marissa J; Langhals, Nicholas B; Purcell, Erin K

    2016-04-01

    Neural prostheses are electrode arrays implanted in the nervous system that record or stimulate electrical activity in neurons. Rapid growth in the use of neural prostheses in research and clinical applications has occurred in recent years, but instability and poor patency in the tissue-electrode interface undermines the longevity and performance of these devices. The application of tissue engineering strategies to the device interface is a promising approach to improve connectivity and communication between implanted electrodes and local neurons, and several research groups have developed new and innovative modifications to neural prostheses with the goal of seamless device-tissue integration. These approaches can be broadly categorized based on the strategy used to maintain and regenerate neurons at the device interface: (1) redesign of the prosthesis architecture to include finer-scale geometries and/or provide topographical cues to guide regenerating neural outgrowth, (2) incorporation of material coatings and bioactive molecules on the prosthesis to improve neuronal growth, viability, and adhesion, and (3) inclusion of cellular grafts to replenish the local neuron population or provide a target site for reinnervation (biohybrid devices). In addition to stabilizing the contact between neurons and electrodes, the potential to selectively interface specific subpopulations of neurons with individual electrode sites is a key advantage of regenerative interfaces. In this study, we review the development of regenerative interfaces for applications in both the peripheral and central nervous system. Current and future development of regenerative interfaces has the potential to improve the stability and selectivity of neural prostheses, improving the patency and resolution of information transfer between neurons and implanted electrodes.

  2. Clinical concepts for regenerative therapy in furcations.

    Science.gov (United States)

    Sanz, Mariano; Jepsen, Karin; Eickholz, Peter; Jepsen, Søren

    2015-06-01

    Furcation involvements present one of the greatest challenges in periodontal therapy because furcation-involved molar teeth respond less favorably to conventional periodontal therapy compared with noninvolved molar or nonmolar teeth. Various regenerative procedures have been proposed and applied with the aim of eliminating the furcation defect or reducing the furcation depth. An abundance of studies and several systematic reviews have established the effectiveness of membrane therapy (guided tissue regeneration) for buccal Class II furcation involvement of mandibular and maxillary molars compared with open flap surgery. Bone grafts/substitutes may enhance the results of guided tissue regeneration. However, complete furcation closure is not a predictable outcome. Limited data and no meta-analyses are available on the effects of enamel matrix proteins for furcation regeneration. Enamel matrix protein therapy has demonstrated clinical improvements in the treatment of buccal Class II furcation defects in mandibular molars; however, complete closure of the furcation lesion is achieved only in a minority of cases. Neither guided tissue regeneration nor enamel matrix protein therapy have demonstrated predictable results for approximal Class II and for Class III furcations. Promising preclinical data from furcation regeneration studies in experimental animals is available for growth factor- and differentiation factor-based technologies, but very limited data are available from human clinical studies. Although cell-based therapies have received considerable attention in regenerative medicine, their experimental evaluation in the treatment of periodontal furcation lesions is at a very early stage of development. In summary, the indications and the limitations for currently available treatment modalities for furcation defects are well established. New regenerative treatments are clearly needed to improve the predictability of a complete resolution of furcation defects.

  3. Cellular cardiac regenerative therapy in which patients?

    Science.gov (United States)

    Chachques, Juan C

    2009-08-01

    Cell-based myocardial regenerative therapy is undergoing experimental and clinical trials in order to limit the consequences of decreased contractile function and compliance of damaged ventricles owing to ischemic and nonischemic myocardial diseases. A variety of myogenic and angiogenic cell types have been proposed, such as skeletal myoblasts, mononuclear and mesenchymal bone marrow cells, circulating blood-derived progenitors, adipose-derived stromal cells, induced pluripotent stem cells, umbilical cord cells, endometrial mesenchymal stem cells, adult testis pluripotent stem cells and embryonic cells. Current indications for stem cell therapy concern patients who have had a left- or right-ventricular infarction or idiopathic dilated cardiomyopathies. Other indications and potential applications include patients with diabetic cardiomyopathy, Chagas heart disease (American trypanosomiasis), ischemic mitral regurgitation, left ventricular noncompacted myocardium and pediatric cardiomyopathy. Suitable sources of cells for cardiac implant will depend on the types of diseases to be treated. For acute myocardial infarction, a cell that reduces myocardial necrosis and augments vascular blood flow will be desirable. For heart failure, cells that replace or promote myogenesis, reverse apoptopic mechanisms and reactivate dormant cell processes will be useful. It is important to note that stem cells are not an alternative to heart transplantation; selected patients should be in an early stage of heart failure as the goal of this regenerative approach is to avoid or delay organ transplantation. Since the cell niche provides crucial support needed for stem cell maintenance, the most interesting and realistic perspectives include the association of intramyocardial cell transplantation with tissue-engineered scaffolds and multisite cardiac pacing in order to transform a passive regenerative approach into a 'dynamic cellular support', a promising method for the creation of

  4. Bioprinting is changing regenerative medicine forever.

    Science.gov (United States)

    Collins, Scott Forrest

    2014-12-01

    3D printing, or solid freeform fabrication, applied to regenerative medicine brings technologies from several industries together to help solve unique challenges in both basic science and tissue engineering. By more finely organizing cells and supporting structures precisely in 3D space, we will gain critical knowledge of cell-cell communications and cell-environment interactions. As we increase the scale, we will move toward complex tissue and organ structures where several cell phenotypes will functionally and structurally interact, thus recapitulating the form and function of native tissues and organs.

  5. MicroRNA Delivery for Regenerative Medicine

    OpenAIRE

    Peng, Bo; Chen, Yongming; Leong, Kam W.

    2015-01-01

    MicroRNA (miRNA) directs post-transcriptional regulation of a network of genes by targeting mRNA. Although relatively recent in development, many miRNAs direct differentiation of various stem cells including induced pluripotent stem cells (iPSCs), a major player in regenerative medicine. An effective and safe delivery of miRNA holds the key to translating miRNA technologies. Both viral and nonviral delivery systems have seen success in miRNA delivery, and each approach possesses advantages an...

  6. Regenerative nanotechnology in oral and maxillofacial surgery.

    Science.gov (United States)

    Shakib, Kaveh; Tan, Aaron; Soskic, Vukic; Seifalian, Alexander M

    2014-12-01

    Regenerative nanotechnology is at the forefront of medical research, and translational medicine is a challenge to both scientists and clinicians. Although there has been an exponential rise in the volume of research generated about it for both medical and surgical uses, key questions remain about its actual benefits. Nevertheless, some people think that therapeutics based on its principles may form the core of applied research for the future. Here we give an account of its current use in oral and maxillofacial surgery, and implications and challenges for the future.

  7. Regenerative Periodontal Therapy: History and Prospects

    Directory of Open Access Journals (Sweden)

    Arasay Calzada Bandomo

    2013-10-01

    Full Text Available Within the field of tissue engineering, in the area of periodontics, the use of matrices for guiding tissue proliferation has included the guided tissue regeneration procedures, which aims at new bone, cementum and desmodontium formation. The present literature review was conducted in order to provide a general and updated overview on the use of these procedures in periodontal therapy. It was concluded that guided tissue regeneration improve the periodontal therapeutic spectrum; that scientific literature supports its choice and, specially the use of membranes to facilitate the regenerative processes of the anomalies caused by periodontal disease and its sequelae.

  8. Biomaterials and Stem Cells in Regenerative Medicine

    CERN Document Server

    Ramalingam, Murugan; Best, Serena

    2012-01-01

    Work in the area of biomaterials and stem cell therapy has revealed great potential for many applications, from the treatment of localized defects and diseases to the repair and replacement of whole organs. Researchers have also begun to develop a better understanding of the cellular environment needed for optimal tissue repair and regeneration. Biomaterials and Stem Cells in Regenerative Medicine explores a range of applications for biomaterials and stem cell therapy and describes recent research on suitable cell scaffolds and substrates for tissue repair and reconstruction. Featuring contrib

  9. Modelling and Experimental Study on Active Energy-Regenerative Suspension Structure with Variable Universe Fuzzy PD Control

    Directory of Open Access Journals (Sweden)

    Jiang Liu

    2016-01-01

    Full Text Available A novel electromagnetic active suspension with an energy-regenerative structure is proposed to solve the suspension’s control consumption problem. For this new system, a 2-DOF quarter-car model is built, and dynamics performances are studied using the variable universe fuzzy theory and the PD control approach. A self-powered efficiency concept is defined to describe the regenerative structure’s contribution to the whole control consumption, and its influent factors are also discussed. Simulations are carried out using software Matlab/Simulink, and experiments are conducted on the B-class road. The results demonstrate that the variable universe fuzzy control can recycle more than 18 percent vibration energy and provide over 11 percent power for the control demand. Furthermore, the new suspension system offers a smaller body acceleration and decreases dynamic tire deflection compared to the passive ones, so as to improve both the ride comfort and the safety.

  10. Vibration transmissibility characteristics of smart spring vibration isolation system

    Institute of Scientific and Technical Information of China (English)

    倪德; 朱如鹏; 陆凤霞; 鲍和云; 付秋菊

    2014-01-01

    The objective of this work was to study the vibration transmissibility characteristics of the undamped and damped smart spring systems. The frequency response characteristics of them were analyzed by using the equivalent linearization technique, and the possible types of the system motion were distinguished by using the starting and ending frequencies. The influences of system parameters on the vibration transmissibility characteristics were discussed. The following conclusions may be drawn from the analysis results. The undamped smart spring system may simultaneously have one starting frequency and one ending frequency or only have one starting frequency, and the damped system may simultaneously have two starting frequencies and one ending frequency. There is an optimal control parameter to make the peak value of the vibration transmissibility curve of the system be minimum. When the mass ratio is far away from the stiffness ratio, the vibration transmissibility is small. The effect of the damping ratio on the system vibration transmissibility is significant while the control parameter is less than its optimal value. But the influence of the relative damping ratio on the vibration transmissibility is small.

  11. Engineering growth factors for regenerative medicine applications.

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Aaron C.; Briquez, Priscilla S.; Hubbell, Jeffrey A.; Cochran, Jennifer R.

    2016-01-15

    Growth factors are important morphogenetic proteins that instruct cell behavior and guide tissue repair and renewal. Although their therapeutic potential holds great promise in regenerative medicine applications, translation of growth factors into clinical treatments has been hindered by limitations including poor protein stability, low recombinant expression yield, and suboptimal efficacy. This review highlights current tools, technologies, and approaches to design integrated and effective growth factor-based therapies for regenerative medicine applications. The first section describes rational and combinatorial protein engineering approaches that have been utilized to improve growth factor stability, expression yield, biodistribution, and serum half-life, or alter their cell trafficking behavior or receptor binding affinity. The second section highlights elegant biomaterial-based systems, inspired by the natural extracellular matrix milieu, that have been developed for effective spatial and temporal delivery of growth factors to cell surface receptors. Although appearing distinct, these two approaches are highly complementary and involve principles of molecular design and engineering to be considered in parallel when developing optimal materials for clinical applications.

  12. Geoengineering in the Anthropocene through Regenerative Urbanism

    Directory of Open Access Journals (Sweden)

    Giles Thomson

    2016-10-01

    Full Text Available Human consumption patterns exceed planetary boundaries and stress on the biosphere can be expected to worsen. The recent “Paris Agreement” (COP21 represents a major international attempt to address risk associated with climate change through rapid decarbonisation. The mechanisms for implementation are yet to be determined and, while various large-scale geoengineering projects have been proposed, we argue a better solution may lie in cities. Large-scale green urbanism in cities and their bioregions would offer benefits commensurate to alternative geoengineering proposals, but this integrated approach carries less risk and has additional, multiple, social and economic benefits in addition to a reduction of urban ecological footprint. However, the key to success will require policy writers and city makers to deliver at scale and to high urban sustainability performance benchmarks. To better define urban sustainability performance, we describe three horizons of green urbanism: green design, that seeks to improve upon conventional development; sustainable development, that is the first step toward a net zero impact; and the emerging concept of regenerative urbanism, that enables biosphere repair. Examples of green urbanism exist that utilize technology and design to optimize urban metabolism and deliver net positive sustainability performance. If mainstreamed, regenerative approaches can make urban development a major urban geoengineering force, while simultaneously introducing life-affirming co-benefits to burgeoning cities.

  13. Extracellular Vesicles: potential roles in Regenerative Medicine

    Directory of Open Access Journals (Sweden)

    Olivier G de Jong

    2014-12-01

    Full Text Available Extracellular vesicles (EV consist of exosomes, which are released upon fusion of the multivesicular body with the cell membrane, and microvesicles, which are released directly from the cell membrane. EV can mediate cell-cell communication and are involved in many processes, including immune signaling, angiogenesis, stress response, senescence, proliferation, and cell differentiation. The vast amount of processes that EV are involved in and the versatility of manner in which they can influence the behavior of recipient cells make EV an interesting source for both therapeutic and diagnostic applications. Successes in the fields of tumor biology and immunology sparked the exploration of the potential of EV in the field of regenerative medicine. Indeed, EV are involved in restoring tissue and organ damage, and may partially explain the paracrine effects observed in stem cell based therapeutic approaches. The function and content of EV may also harbor information that can be used in tissue engineering, in which paracrine signaling is employed to modulate cell recruitment, differentiation, and proliferation. In this review, we discuss the function and role of EV in regenerative medicine and elaborate on potential applications in tissue engineering.

  14. Regenerative fuel cell systems R and D

    Energy Technology Data Exchange (ETDEWEB)

    Mitlitsky, F.; Myers, B.; Weisberg, A.H. [Lawrence Livermore National Lab., Livermore, CA (United States)

    1998-08-01

    Regenerative fuel cell (RFC) systems produce power and electrolytically regenerate their reactants using stacks of electrochemical cells. Energy storage systems with extremely high specific energy (> 400 Wh/kg) have been designed that use lightweight pressure vessels to contain the gases generated by reversible (unitized) regenerative fuel cells (URFCs). Progress is reported on the development, integration, and operation of rechargeable energy storage systems with such high specific energy. Lightweight pressure vessels that enable high specific energies have been designed with performance factors (burst pressure/internal volume/tank weight) > 50 km (2.0 million inches), and a vessel with performance factor of 40 km (1.6 million inches) was fabricated. New generations of both advanced and industry-supplied hydrogen tankage are under development. A primary fuel cell test rig with a single cell (46 cm{sup 2} active area) has been modified and operated reversibly as a URFC (for up to 2010 cycles on a single cell). This URFC uses bifunctional electrodes (oxidation and reduction electrodes reverse roles when switching from charge to discharge, as with a rechargeable battery) and cathode feed electrolysis (water is fed from the hydrogen side of the cell). Recent modifications also enable anode feed electrolysis (water is fed from the oxygen side of the cell). Hydrogen/halogen URFCs, capable of higher round-trip efficiency than hydrogen/oxygen URFCs, have been considered, and will be significantly heavier. Progress is reported on higher performance hydrogen/oxygen URFC operation with reduced catalyst loading.

  15. Scaffolds in regenerative endodontics: A review

    Directory of Open Access Journals (Sweden)

    Kinjal M Gathani

    2016-01-01

    Full Text Available Root canal therapy has enabled us to save numerous teeth over the years. The most desired outcome of endodontic treatment would be when diseased or nonvital pulp is replaced with healthy pulp tissue that would revitalize the teeth through regenerative endodontics. ′A search was conducted using the Pubmed and MEDLINE databases for articles with the criteria ′Platelet rich plasma′, ′Platelet rich fibrin′, ′Stem cells′, ′Natural and artificial scaffolds′ from 1982-2015′. Tissues are organized as three-dimensional structures, and appropriate scaffolding is necessary to provide a spatially correct position of cell location and regulate differentiation, proliferation, or metabolism of the stem cells. Extracellular matrix molecules control the differentiation of stem cells, and an appropriate scaffold might selectively bind and localize cells, contain growth factors, and undergo biodegradation over time. Different scaffolds facilitate the regeneration of different tissues. To ensure a successful regenerative procedure, it is essential to have a thorough and precise knowledge about the suitable scaffold for the required tissue. This article gives a review on the different scaffolds providing an insight into the new developmental approaches on the horizon.

  16. Scaffolds in regenerative endodontics: A review

    Science.gov (United States)

    Gathani, Kinjal M.; Raghavendra, Srinidhi Surya

    2016-01-01

    Root canal therapy has enabled us to save numerous teeth over the years. The most desired outcome of endodontic treatment would be when diseased or nonvital pulp is replaced with healthy pulp tissue that would revitalize the teeth through regenerative endodontics. ‘A search was conducted using the Pubmed and MEDLINE databases for articles with the criteria ‘Platelet rich plasma’, ‘Platelet rich fibrin’, ‘Stem cells’, ‘Natural and artificial scaffolds’ from 1982–2015’. Tissues are organized as three-dimensional structures, and appropriate scaffolding is necessary to provide a spatially correct position of cell location and regulate differentiation, proliferation, or metabolism of the stem cells. Extracellular matrix molecules control the differentiation of stem cells, and an appropriate scaffold might selectively bind and localize cells, contain growth factors, and undergo biodegradation over time. Different scaffolds facilitate the regeneration of different tissues. To ensure a successful regenerative procedure, it is essential to have a thorough and precise knowledge about the suitable scaffold for the required tissue. This article gives a review on the different scaffolds providing an insight into the new developmental approaches on the horizon. PMID:27857762

  17. Integrated regenerative fuel cell experimental evaluation

    Science.gov (United States)

    Martin, Ronald E.

    1990-01-01

    An experimental test program was conducted to investigate the performance characteristics of an integrated regenerative fuel cell (IRFC) concept. The IRFC consists of a separate fuel cell unit and electrolysis cell unit in the same structure, with internal storage of fuel cell product water and external storage of electrolysis cell produced hydrogen and oxygen. The fuel cell unit incorporates an enhanced Orbiter-type cell capable of improved performance at reduced weight. The electrolysis cell features a NiCo2O4 catalyst oxygen evolution eletrode with a porous Teflon cover to retard electrolyte loss. Six complete IRFC assemblies were assembled and performance tested at an operating temperature of 200 F (93.3 C) and reactant pressures up to 170 psia (117.2 n/cu cm) on IRFC No. 4. Anomalous pressure charge/discharge characteristics were encountered during performance evaluation. A reversible fuel cell incorporating a proprietary bi-functional oxygen electrode operated satisfactory at 200 F (93.3 C) at reactant pressures up to 50 psia (41.4 n/cu cm) as a regenerative fuel cell for one cycle, before developing an electrical short in the fuel cell mode. Electrolysis cell 300-hour endurance tests demonstrated the electrolyte retention capability of the electrode Teflon cover and the performance stability of the bi-functional oxygen electrode at high potential.

  18. Translational science in disinfection for regenerative endodontics.

    Science.gov (United States)

    Diogenes, Anibal R; Ruparel, Nikita B; Teixeira, Fabricio B; Hargreaves, Kenneth M

    2014-04-01

    The endodontic management of permanent immature teeth is fraught with challenges. Although treatment modalities for vital pulp therapy in these teeth provide long-term favorable outcome, the outcomes from the treatment of pulp necrosis and apical periodontitis are significantly less predictable. Immature teeth diagnosed with pulp necrosis have been traditionally treated with apexification or apexogenesis approaches. Unfortunately, these treatments provide little to no benefit in promoting continued root development. Regenerative endodontic procedures have emerged as an important alternative in treating teeth with otherwise questionable long-term prognosis because of thin, fragile dentinal walls and a lack of immunocompetency. These procedures rely heavily on root canal chemical disinfection of the root canal system. Traditionally, irrigants and medicaments have been chosen for their maximum antimicrobial effect without consideration for their effects on stem cells and the dentinal microenvironment. Translational research has been crucial to provide evidence for treatment modifications that aim to increase favorable outcome while steering away from common pitfalls in the currently used protocols. In this review, recent advances learned from translational research related to disinfection in regenerative endodontics are presented and discussed. Copyright © 2014 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  19. Scaffolds in regenerative endodontics: A review.

    Science.gov (United States)

    Gathani, Kinjal M; Raghavendra, Srinidhi Surya

    2016-09-01

    Root canal therapy has enabled us to save numerous teeth over the years. The most desired outcome of endodontic treatment would be when diseased or nonvital pulp is replaced with healthy pulp tissue that would revitalize the teeth through regenerative endodontics. 'A search was conducted using the Pubmed and MEDLINE databases for articles with the criteria 'Platelet rich plasma', 'Platelet rich fibrin', 'Stem cells', 'Natural and artificial scaffolds' from 1982-2015'. Tissues are organized as three-dimensional structures, and appropriate scaffolding is necessary to provide a spatially correct position of cell location and regulate differentiation, proliferation, or metabolism of the stem cells. Extracellular matrix molecules control the differentiation of stem cells, and an appropriate scaffold might selectively bind and localize cells, contain growth factors, and undergo biodegradation over time. Different scaffolds facilitate the regeneration of different tissues. To ensure a successful regenerative procedure, it is essential to have a thorough and precise knowledge about the suitable scaffold for the required tissue. This article gives a review on the different scaffolds providing an insight into the new developmental approaches on the horizon.

  20. PRMT7 Preserves Satellite Cell Regenerative Capacity.

    Science.gov (United States)

    Blanc, Roméo Sébastien; Vogel, Gillian; Chen, Taiping; Crist, Colin; Richard, Stéphane

    2016-02-16

    Regeneration of skeletal muscle requires the continued presence of quiescent muscle stem cells (satellite cells), which become activated in response to injury. Here, we report that whole-body protein arginine methyltransferase PRMT7(-/-) adult mice and mice conditionally lacking PRMT7 in satellite cells using Pax7-CreERT2 both display a significant reduction in satellite cell function, leading to defects in regenerative capacity upon muscle injury. We show that PRMT7 is preferentially expressed in activated satellite cells and, interestingly, PRMT7-deficient satellite cells undergo cell-cycle arrest and premature cellular senescence. These defects underlie poor satellite cell stem cell capacity to regenerate muscle and self-renew after injury. PRMT7-deficient satellite cells express elevated levels of the CDK inhibitor p21CIP1 and low levels of its repressor, DNMT3b. Restoration of DNMT3b in PRMT7-deficient cells rescues PRMT7-mediated senescence. Our findings define PRMT7 as a regulator of the DNMT3b/p21 axis required to maintain muscle stem cell regenerative capacity.

  1. Analysis of Regen Cooling in Rocket Combustors

    Science.gov (United States)

    Harper, Brent (Technical Monitor); Merkle, C. L.; Li, D.; Sankaran, V.

    2004-01-01

    The use of detailed CFD modeling for the description of cooling in rocket chambers is discussed. The overall analysis includes a complete three-dimensional analysis of the flow in the regenerative cooling passages, conjugate heat transfer in the combustor walls, and the effects of film cooling on the inside chamber. The results in the present paper omit the effects of film cooling and include only regen cooling and the companion conjugate heat transfer. The hot combustion gases are replaced by a constant temperature wall boundary condition. Load balancing for parallel cluster computations is ensured by using single-block unstructured grids for both fluids and solids, and by using a 'multiple physical zones' to account for differences in the number of equations. Validation of the method is achieved by comparing simple two-dimensional solutions with analytical results. Representative results for cooling passages are presents showing the effects of heat conduction in the copper walls with tube aspect ratios of 1.5:l.

  2. PRMT7 Preserves Satellite Cell Regenerative Capacity

    Directory of Open Access Journals (Sweden)

    Roméo Sébastien Blanc

    2016-02-01

    Full Text Available Regeneration of skeletal muscle requires the continued presence of quiescent muscle stem cells (satellite cells, which become activated in response to injury. Here, we report that whole-body protein arginine methyltransferase PRMT7−/− adult mice and mice conditionally lacking PRMT7 in satellite cells using Pax7-CreERT2 both display a significant reduction in satellite cell function, leading to defects in regenerative capacity upon muscle injury. We show that PRMT7 is preferentially expressed in activated satellite cells and, interestingly, PRMT7-deficient satellite cells undergo cell-cycle arrest and premature cellular senescence. These defects underlie poor satellite cell stem cell capacity to regenerate muscle and self-renew after injury. PRMT7-deficient satellite cells express elevated levels of the CDK inhibitor p21CIP1 and low levels of its repressor, DNMT3b. Restoration of DNMT3b in PRMT7-deficient cells rescues PRMT7-mediated senescence. Our findings define PRMT7 as a regulator of the DNMT3b/p21 axis required to maintain muscle stem cell regenerative capacity.

  3. Vibrational stability of graphene

    Directory of Open Access Journals (Sweden)

    Yangfan Hu

    2013-05-01

    Full Text Available The mechanical stability of graphene as temperature rises is analyzed based on three different self-consistent phonon (SCP models. Compared with three-dimensional (3-D materials, the critical temperature Ti at which instability occurs for graphene is much closer to its melting temperature Tm obtained from Monte Carlo simulation (Ti ≃ 2Tm, K. V. Zakharchenko, A. Fasolino, J. H. Los, and M. I. Katsnelson, J. Phys. Condens. Matter 23, 202202. This suggests that thermal vibration plays a significant role in melting of graphene while melting for 3-D materials is often dominated by topologic defects. This peculiar property of graphene derives from its high structural anisotropy, which is characterized by the vibrational anisotropic coefficient (VAC, defined upon its Lindermann ratios in different directions. For any carbon based material with a graphene-like structure, the VAC value must be smaller than 5.4 to maintain its stability. It is also found that the high VAC value of graphene is responsible for its negative thermal expansion coefficient at low temperature range. We believe that the VAC can be regarded as a new criterion concerning the vibrational stability of any low-dimensional (low-D materials.

  4. Theory of vibration protection

    CERN Document Server

    Karnovsky, Igor A

    2016-01-01

    This text is an advancement of the theory of vibration protection of mechanical systems with lumped and distributed parameters. The book offers various concepts and methods of solving vibration protection problems, discusses the advantages and disadvantages of different methods, and the fields of their effective applications. Fundamental approaches of vibration protection, which are considered in this book, are the passive, parametric and optimal active vibration protection. The passive vibration protection is based on vibration isolation, vibration damping and dynamic absorbers. Parametric vibration protection theory is based on the Shchipanov-Luzin invariance principle. Optimal active vibration protection theory is based on the Pontryagin principle and the Krein moment method. The book also contains special topics such as suppression of vibrations at the source of their occurrence and the harmful influence of vibrations on humans. Numerous examples, which illustrate the theoretical ideas of each chapter, ar...

  5. Coupling between plate vibration and acoustic radiation

    Science.gov (United States)

    Frendi, Abdelkader; Maestrello, Lucio; Bayliss, Alvin

    1993-01-01

    A detailed numerical investigation of the coupling between the vibration of a flexible plate and the acoustic radiation is performed. The nonlinear Euler equations are used to describe the acoustic fluid while the nonlinear plate equation is used to describe the plate vibration. Linear, nonlinear, and quasi-periodic or chaotic vibrations and the resultant acoustic radiation are analyzed. We find that for the linear plate response, acoustic coupling is negligible. However, for the nonlinear and chaotic responses, acoustic coupling has a significant effect on the vibration level as the loading increases. The radiated pressure from a plate undergoing nonlinear or chaotic vibrations is found to propagate nonlinearly into the far field. However, the nonlinearity due to wave propagation is much weaker than that due to the plate vibrations. As the acoustic wave propagates into the far field, the relative difference in level between the fundamental and its harmonics and subharmonics decreases with distance.

  6. Stem cells: intellectual property issues in regenerative medicine.

    Science.gov (United States)

    Zachariades, Nicholas A

    2013-12-01

    The topic of stem cells for use in regenerative medicine, especially embryonic stem cells, inspires much debate, discussion, and outrage as it slices through the very core moral values of society. These social and moral issues have, in turn, resulted in government policies that have influenced the study of stem cells in regenerative medicine.

  7. State of the art: stem cells in equine regenerative medicine.

    Science.gov (United States)

    Lopez, M J; Jarazo, J

    2015-03-01

    According to Greek mythology, Prometheus' liver grew back nightly after it was removed each day by an eagle as punishment for giving mankind fire. Hence, contrary to popular belief, the concept of tissue and organ regeneration is not new. In the early 20th century, cell culture and ex vivo organ preservation studies by Alexis Carrel, some with famed aviator Charles Lindbergh, established a foundation for much of modern regenerative medicine. While early beliefs and discoveries foreshadowed significant accomplishments in regenerative medicine, advances in knowledge within numerous scientific disciplines, as well as nano- and micromolecular level imaging and detection technologies, have contributed to explosive advances over the last 20 years. Virtually limitless preparations, combinations and applications of the 3 major components of regenerative medicine, namely cells, biomaterials and bioactive molecules, have created a new paradigm of future therapeutic options for most species. It is increasingly clear, however, that despite significant parallels among and within species, there is no 'one-size-fits-all' regenerative therapy. Likewise, a panacea has yet to be discovered that completely reverses the consequences of time, trauma and disease. Nonetheless, there is no question that the promise and potential of regenerative medicine have forever altered medical practices. The horse is a relative newcomer to regenerative medicine applications, yet there is already a large body of work to incorporate novel regenerative therapies into standard care. This review focuses on the current state and potential future of stem cells in equine regenerative medicine.

  8. Electrolyte for batteries with regenerative solid electrolyte interface

    Energy Technology Data Exchange (ETDEWEB)

    Xiao, Jie; Lu, Dongping; Shao, Yuyan; Bennett, Wendy D.; Graff, Gordon L.; Liu, Jun; Zhang, Ji-Guang

    2017-08-01

    An energy storage device comprising: an anode; and a solute-containing electrolyte composition wherein the solute concentration in the electrolyte composition is sufficiently high to form a regenerative solid electrolyte interface layer on a surface of the anode only during charging of the energy storage device, wherein the regenerative layer comprises at least one solute or solvated solute from the electrolyte composition.

  9. Angular vibrations of cryogenically cooled double-crystal monochromators.

    Science.gov (United States)

    Sergueev, I; Döhrmann, R; Horbach, J; Heuer, J

    2016-09-01

    The effect of angular vibrations of the crystals in cryogenically cooled monochromators on the beam performance has been studied theoretically and experimentally. A simple relation between amplitude of the vibrations and size of the focused beam is developed. It is shown that the double-crystal monochromator vibrations affect not only the image size but also the image position along the optical axis. Several methods to measure vibrations with the X-ray beam are explained and analyzed. The methods have been applied to systematically study angular crystal vibrations at monochromators installed at the PETRA III light source. Characteristic values of the amplitudes of angular vibrations for different monochromators are presented.

  10. Torsional Vibration Analysis of an FR Driveline System

    Institute of Scientific and Technical Information of China (English)

    任少云; 朱正礼; 张建武

    2004-01-01

    Towing tractor drivelines are lightly damped non-linear systems. Interactions between components can cause dynamic behavors such as gear gap impact in gear transmissions, shuffle and clonk phenomena in driveline. The torsional vibration of driveline has an important effect on grand engineering vehicle vibration and noise. Through analyzing torsional vibration equations of driveline, torsional vibration model of driveline is developed by using Matlab/Simulink software, Shuffle and clonk phenomena are observed in torsional vibration. The modeling method of analysizing driveline torsional vibration can be used to research and improve similar engineering vehicle driveline behavors.

  11. Stem Cells Applications in Regenerative Medicine and Disease Therapeutics.

    Science.gov (United States)

    Mahla, Ranjeet Singh

    2016-01-01

    Regenerative medicine, the most recent and emerging branch of medical science, deals with functional restoration of tissues or organs for the patient suffering from severe injuries or chronic disease. The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by conventional medicines. The indefinite self-renewal and potential to differentiate into other types of cells represent stem cells as frontiers of regenerative medicine. The transdifferentiating potential of stem cells varies with source and according to that regenerative applications also change. Advancements in gene editing and tissue engineering technology have endorsed the ex vivo remodelling of stem cells grown into 3D organoids and tissue structures for personalized applications. This review outlines the most recent advancement in transplantation and tissue engineering technologies of ESCs, TSPSCs, MSCs, UCSCs, BMSCs, and iPSCs in regenerative medicine. Additionally, this review also discusses stem cells regenerative application in wildlife conservation.

  12. Evaluation strategy of regenerative braking energy for supercapacitor vehicle.

    Science.gov (United States)

    Zou, Zhongyue; Cao, Junyi; Cao, Binggang; Chen, Wen

    2015-03-01

    In order to improve the efficiency of energy conversion and increase the driving range of electric vehicles, the regenerative energy captured during braking process is stored in the energy storage devices and then will be re-used. Due to the high power density of supercapacitors, they are employed to withstand high current in the short time and essentially capture more regenerative energy. The measuring methods for regenerative energy should be investigated to estimate the energy conversion efficiency and performance of electric vehicles. Based on the analysis of the regenerative braking energy system of a supercapacitor vehicle, an evaluation system for energy recovery in the braking process is established using USB portable data-acquisition devices. Experiments under various braking conditions are carried out. The results verify the higher efficiency of energy regeneration system using supercapacitors and the effectiveness of the proposed measurement method. It is also demonstrated that the maximum regenerative energy conversion efficiency can reach to 88%.

  13. Reliability Analysis of Random Vibration Transmission Path Systems

    Directory of Open Access Journals (Sweden)

    Wei Zhao

    2017-01-01

    Full Text Available The vibration transmission path systems are generally composed of the vibration source, the vibration transfer path, and the vibration receiving structure. The transfer path is the medium of the vibration transmission. Moreover, the randomness of transfer path influences the transfer reliability greatly. In this paper, based on the matrix calculus, the generalized second moment technique, and the stochastic finite element theory, the effective approach for the transfer reliability of vibration transfer path systems was provided. The transfer reliability of vibration transfer path system with uncertain path parameters including path mass and path stiffness was analyzed theoretically and computed numerically, and the correlated mathematical expressions were derived. Thus, it provides the theoretical foundation for the dynamic design of vibration systems in practical project, so that most random path parameters can be considered to solve the random problems for vibration transfer path systems, which can avoid the system resonance failure.

  14. Researches on regenerative medicine——current state and prospect

    Institute of Scientific and Technical Information of China (English)

    WANG Zheng-guo; XIAO Kai

    2012-01-01

    Since 1980s,the rapid development of tissue engineering and stem cell research has pushed regenerative medicine to a new fastigium,and regenerative medicine has become a noticeable research field in the international biology and medicine.In China,about 100 million patients need repair and regeneration treatment every year,while the number is much larger in the world.Regenerative medicine could provide effective salvation for these patients.Both Chinese Academy of Sciences and Chinese Academy of Engineering have made roadmaps of 2010-2050 and 2011-2030 for regenerative medicine.The final goal of the two roadmaps is to make China go up to leading position in most research aspects of regenerative medicine.In accord with this strategy,the government and some enterprises have invested 3-5 billion RMB (0.5-0.8 billion USD)for the research on regenerative medicine.In order to push the translation of regenerative medicine forward - from bench to bedside,a strategic alliance has been established.and it includes 27 top-level research institutes,medical institutes,colleges,universities and enterprises in the field of stem cell and regeneration medicine.Recently the journal,Science,has published a special issue-Regenerative Medicine in China,consisting of 35 papers dealing with stem cell and regeneration,tissue engineering and regeneration,trauma and regeneration and bases for tissue repair and regenerative medicine.It is predicated that a greater breakthrough in theory and practice of regenerative medicine will be achieved in the near future (20 to 30 years).

  15. Genetic engineering for skeletal regenerative medicine.

    Science.gov (United States)

    Gersbach, Charles A; Phillips, Jennifer E; García, Andrés J

    2007-01-01

    The clinical challenges of skeletal regenerative medicine have motivated significant advances in cellular and tissue engineering in recent years. In particular, advances in molecular biology have provided the tools necessary for the design of gene-based strategies for skeletal tissue repair. Consequently, genetic engineering has emerged as a promising method to address the need for sustained and robust cellular differentiation and extracellular matrix production. As a result, gene therapy has been established as a conventional approach to enhance cellular activities for skeletal tissue repair. Recent literature clearly demonstrates that genetic engineering is a principal factor in constructing effective methods for tissue engineering approaches to bone, cartilage, and connective tissue regeneration. This review highlights this literature, including advances in the development of efficacious gene carriers, novel cell sources, successful delivery strategies, and optimal target genes. The current status of the field and the challenges impeding the clinical realization of these approaches are also discussed.

  16. Electrospinning of polysaccharides for regenerative medicine.

    Science.gov (United States)

    Lee, Kuen Yong; Jeong, Lim; Kang, Yun Ok; Lee, Seung Jin; Park, Won Ho

    2009-10-05

    Electrospinning techniques enable the production of continuous fibers with dimensions on the scale of nanometers from a wide range of natural and synthetic polymers. The number of recent studies regarding electrospun polysaccharides and their derivatives, which are potentially useful for regenerative medicine, is increasing dramatically. However, difficulties regarding the processibility of the polysaccharides (e.g., poor solubility and high surface tension) have limited their application. In this review, we summarize the characteristics of various polysaccharides such as alginate, cellulose, chitin, chitosan, hyaluronic acid, starch, dextran, and heparin, which are either currently being used or have potential to be used for electrospinning. The recent progress of nanofiber matrices electrospun from polysaccharides and their biomedical applications in tissue engineering, wound dressings, drug delivery, and enzyme immobilization are discussed.

  17. Analysis of room temperature magnetic regenerative refrigeration

    Energy Technology Data Exchange (ETDEWEB)

    Shir, F.; Mavriplis, C.; Bennett, L.H.; Torre, E.D. [George Washington University, Washington, DC (United States). Institute for Magnetics Research

    2005-06-01

    Results of a room temperature magnetic refrigeration test bed and an analysis using a computational model are presented. A detailed demonstration of the four sequential processes in the transient magnetocaloric regeneration process of a magnetic material is presented. The temperature profile during the transient approach to steady state operation was measured in detail. A 5 {sup o}C evolution of the difference of temperature between the hot end and the cold end of the magnetocaloric bed due to regeneration is reported. A model is developed for the heat transfer and fluid mechanics of the four sequential processes in each cycle of thermal wave propagation in the regenerative bed combined with the magnetocaloric effect. The basic equations that can be used in simulation of magnetic refrigeration systems are derived and the design parameters are discussed. (author)

  18. A regenerative approach towards mucosal fenestration closure.

    Science.gov (United States)

    Gandi, Padma; Anumala, Naveen; Reddy, Amarender; Chandra, Rampalli Viswa

    2013-06-06

    Mucosal fenestration is an opening or an interstice through the oral mucosa. A lesion which occurs with greater frequency than generally realised, its occurrence is attributed to a myriad of causes. Mucogingival procedures including connective tissue grafts, free gingival grafts and lateral pedicle grafts are generally considered to be the treatment of choice in the closure of a mucosal fenestration. More often, these procedures are performed in conjunction with other procedures such as periradicular surgery and with bone grafts. However, the concomitant use of gingival grafts and bone grafts in mucosal fenestrations secondary to infections in sites exhibiting severe bone loss is highly debatable. In this article, we report two cases of mucosal fenestrations secondary to trauma and their management by regenerative periodontal surgery with the placement of guided tissue regeneration membrane and bone graft. The final outcome was a complete closure of the fenestration in both the cases.

  19. Tissue Engineering in Regenerative Dental Therapy

    Directory of Open Access Journals (Sweden)

    Hiral Jhaveri-Desai

    2011-01-01

    Full Text Available Tissue engineering is amongst the latest exciting technologies having impacted the field of dentistry. Initially considered as a futuristic approach, tissue engineering is now being successfully applied in regenerative surgery. This article reviews the important determinants of tissue engineering and how they contribute to the improvement of wound healing and surgical outcomes in the oral region. Furthermore, we shall address the clinical applications of engineering involving oral and maxillofacial surgical and periodontal procedures along with other concepts that are still in experimental phase of development. This knowledge will aid the surgical and engineering researchers to comprehend the collaboration between these fields leading to extounding dental applications and to ever-continuing man-made miracles in the field of human science.

  20. Parametric Vibration and Vibration Reduction of Cables in Cable-stayed Space Latticed Structure

    Institute of Scientific and Technical Information of China (English)

    BAO Yan; ZHOU Dai; LIU Jie

    2008-01-01

    Mechanical model and vibration equation of a cable in cable-stayed sparse latticed structure (CSLS) under external axial excitation were founded. Determination of the mass lumps and natural frequencies supplied by the space latticed structure (SLS) was analyzed. Multiple scales method (MSM) was introduced to analyze the characteristics of cable's parametric vibration, and the precise time-integration method (PTIM) was used to solve vibration equation. The vibration behavior of a cable is closely relative to the frequency ratio of the cable and SLS. The cable's parametric vibration caused by the external axial excitation easily occurs if the frequency ratio of the cable and SLS is in a certain range, and the cable's vibration amplitude varies greatly even if the initial disturbance supplied by SLS changes a little. Furthermore, the mechanical model and vibration equation of the composite cable system consisting of main cables and assistant cables were studied. The parametric analysis such as the pre-tension level and arrangement of the assistant cables was carried out. Due to the assistant cables, the single-cable vibration mode can be transferred to the global vibration mode, and the stiffness and damping of the cable system are enhanced. The natural frequencies of the composite cable system with the curve line arrangement of assistant cables are higher than those with the straight-line arrangement and the former is more effective than the latter on the cable's vibration suppression.

  1. Eco-inventory for energy systems: Example regenerative energy systems; Oekoinventare fuer Energiesysteme: Beispiel regenerative Energiesysteme

    Energy Technology Data Exchange (ETDEWEB)

    Doka, G. [Inst. fuer Energietechnik, ETH, Zurich (Switzerland); Frischknecht, R. [Inst. fuer Energietechnik, ETH, Zurich (Switzerland); Hofstetter, P. [Inst. fuer Energietechnik, ETH, Zurich (Switzerland); Knoepfel, I. [Inst. fuer Energietechnik, ETH, Zurich (Switzerland); Suter, P. [Inst. fuer Energietechnik, ETH, Zurich (Switzerland); Walder, E. [Inst. fuer Energietechnik, ETH, Zurich (Switzerland); Dones, R. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1995-10-01

    The article describes the relevant process chains for the final energy supply from regenerative energy sources and the occurring environmental effects, such as emissions of noxious matter and consumption of resources. There is considered the electricity generation in photo-voltaic small-scale plants and water power plants. (orig.) [Deutsch] Der Beitrag beschreibt zur Endenergiebereitstellung aus regenerativen Energiequellen massgeblichen Prozessketten und die dabei auftretenden Umwelteinwirkungen, wie Schadstoffemissionen und Ressourcenverbraeuche. Betrachtet wird die Elektrizitaetserzeugung in photovoltaischen Kleinanlagen und Wasserkraftanlagen. (orig.)

  2. Heat cascading regenerative sorption heat pump

    Science.gov (United States)

    Jones, Jack A. (Inventor)

    1995-01-01

    A simple heat cascading regenerative sorption heat pump process with rejected or waste heat from a higher temperature chemisorption circuit (HTCC) powering a lower temperature physisorption circuit (LTPC) which provides a 30% total improvement over simple regenerative physisorption compression heat pumps when ammonia is both the chemisorbate and physisorbate, and a total improvement of 50% or more for LTPC having two pressure stages. The HTCC contains ammonia and a chemisorbent therefor contained in a plurality of canisters, a condenser-evaporator-radiator system, and a heater, operatively connected together. The LTPC contains ammonia and a physisorbent therefor contained in a plurality of compressors, a condenser-evaporator-radiator system, operatively connected together. A closed heat transfer circuit (CHTC) is provided which contains a flowing heat transfer liquid (FHTL) in thermal communication with each canister and each compressor for cascading heat from the HTCC to the LTPC. Heat is regenerated within the LTPC by transferring heat from one compressor to another. In one embodiment the regeneration is performed by another CHTC containing another FHTL in thermal communication with each compressor. In another embodiment the HTCC powers a lower temperature ammonia water absorption circuit (LTAWAC) which contains a generator-absorber system containing the absorbent, and a condenser-evaporator-radiator system, operatively connected together. The absorbent is water or an absorbent aqueous solution. A CHTC is provided which contains a FHTL in thermal communication with the generator for cascading heat from the HTCC to the LTAWAC. Heat is regenerated within the LTAWAC by transferring heat from the generator to the absorber. The chemical composition of the chemisorbent is different than the chemical composition of the physisorbent, and the absorbent. The chemical composition of the FHTL is different than the chemisorbent, the physisorbent, the absorbent, and ammonia.

  3. Vibration diagnostics of weak base embankments

    Institute of Scientific and Technical Information of China (English)

    Evgenij Ashpiz; Vladimir Kapustin; Svetlana Klepikova; Maxim Shirobokov

    2013-01-01

    In this paper the theoretical background was analyzed for vibration diagnostics method and experience in its application for weak base embankments. General schemes of survey and recommendations on hardware systems and further prospective development are outlined.

  4. Analyzing Carbohydrate-Based Regenerative Fuel Cells as a Power Source for Unmanned Aerial Vehicles

    Science.gov (United States)

    2008-03-01

    different researchers. As an example, one fuel cell was reported to have a 95% efficiency [ Weibel and Dodge, 1975] however, upon closer inspection...implants, in 19th IEEE International Conference on Mi- cro Electro Mechanical Systems, vol. 2006, pp. 934–937. Weibel , M. K., and C. Dodge (1975

  5. Vibration Characteristics of An Offshore Platform and Its Vibration Control

    Institute of Scientific and Technical Information of China (English)

    李华军; 王树青; 杨永春; 王燕

    2002-01-01

    A template offshore platform, located in the Bohai Bay of China, has exhibited excessive, unexpected vibration un-der mildly hostile sea conditions, which has affected the normal operation of the platform. Since the structure was de-signed to sustain more severe wave climate, the cause of the excessive vibration has been suspected to originate from othersources. The main objectives of this study are to investigate the causes of the excessive vibration, and to explore possibleremedies to solve the problem. In this paper, the vibration behavior of the offshore platform is analyzed by means of finiteelement (FE) modeling, field measurements and laboratory test. Results of analysis suggest that relative movement andimpact between the piles and the jacket legs exist, i.e. the piles and the jacket are not perfectly connected. The discon-nection of the piles and jacket weakens the overall stiffness of the platform, and therefore produces unexpected excessivevibration. In this study, measures for reducing the excessive vibration are proposed to control the response of the platform .

  6. Regenerative medicine through a crisis: social perception and the financial reality.

    Science.gov (United States)

    Brindley, David; Davie, Natasha

    2009-12-01

    The aim of this perspective piece is to highlight how the "social perception" and "financial reality" of regenerative medicine may act to hinder its evolution into the principal health-care option for the future. We also consider the role of the consumer and the need for increased public awareness. Furthermore, we consider the effects of the changing social attitudes toward the field, as well as taking into account the influence of current and future political thinking. From a financial viewpoint, we analyze the compatibility of the current venture capital model with regenerative medicine start-ups and explore approaches to ensure sufficient funding and support throughout all stages of product development, for example, the modularization of funding.

  7. A survey of dental residents' expectations for regenerative endodontics.

    Science.gov (United States)

    Manguno, Christine; Murray, Peter E; Howard, Cameron; Madras, Jonathan; Mangan, Stephen; Namerow, Kenneth N

    2012-02-01

    The objective was to survey a group of dental residents regarding their expectations for using regenerative endodontic procedures as part of future dental treatments. After institutional review board approval, the opinions of 32 dentists who were having postgraduate residency training to become specialists in a dental school were surveyed. The survey had 40 questions about professional status, ethical beliefs, judgment, and clinical practice. It was found that 83.9% of dentists had no continuing education or training in stem cells or regenerative endodontic procedures. Results showed that 96.8% of dentists are willing to receive training to be able to provide regenerative endodontic procedures for their patients. Of the total group, 49.1% of dentists already use membranes, scaffolds, or bioactive materials to provide dental treatment. It was determined that 47.3% of dentists agree that the costs of regenerative procedures should be comparable with current treatments. It was also found that 55.1% of dentists were unsure whether regenerative procedures would be successful. Dentists are supportive of using regenerative endodontic procedures in their dental practice, and they are willing to undergo extra training and to buy new technology to provide new procedures. Nevertheless, dentists also need more evidence for the effectiveness and safety of regenerative treatments before they will be recommended for most patients. Copyright © 2012. Published by Elsevier Inc.

  8. Source model for blasting vibration

    Institute of Scientific and Technical Information of China (English)

    DING; Hua(丁桦); ZHENG; Zhemin(郑哲敏)

    2002-01-01

    By analyzing and comparing the experimental data, the point source moment theory and the cavity theory, it is concluded that the vibrating signals away from the blasting explosive come mainly from the natural vibrations of the geological structures near the broken blasting area. The source impulses are not spread mainly by the inelastic properties (such as through media damping, as believed to be the case by many researchers) of the medium in the propagation pass, but by this structure. Then an equivalent source model for the blasting vibrations of a fragmenting blasting is proposed, which shows the important role of the impulse of the source's time function under certain conditions. For the purpose of numerical simulation, the model is realized in FEM, The finite element results are in good agreement with the experimental data.

  9. Biomolecule delivery to engineer the cellular microenvironment for regenerative medicine.

    Science.gov (United States)

    Bishop, Corey J; Kim, Jayoung; Green, Jordan J

    2014-07-01

    To realize the potential of regenerative medicine, controlling the delivery of biomolecules in the cellular microenvironment is important as these factors control cell fate. Controlled delivery for tissue engineering and regenerative medicine often requires bioengineered materials and cells capable of spatiotemporal modulation of biomolecule release and presentation. This review discusses biomolecule delivery from the outside of the cell inwards through the delivery of soluble and insoluble biomolecules as well as from the inside of the cell outwards through gene transfer. Ex vivo and in vivo therapeutic strategies are discussed, as well as combination delivery of biomolecules, scaffolds, and cells. Various applications in regenerative medicine are highlighted including bone tissue engineering and wound healing.

  10. Regenerative endodontics: barriers and strategies for clinical translation.

    Science.gov (United States)

    Mao, Jeremy J; Kim, Sahng G; Zhou, Jian; Ye, Ling; Cho, Shoko; Suzuki, Takahiro; Fu, Susan Y; Yang, Rujing; Zhou, Xuedong

    2012-07-01

    Regenerative endodontics has encountered substantial challenges toward clinical translation. The adoption by the American Dental Association of evoked pulp bleeding in immature permanent teeth is an important step for regenerative endodontics. However, there is no regenerative therapy for most endodontic diseases. Simple recapitulation of cell therapy and tissue engineering strategies that are under development for other organ systems has not led to clinical translation in regeneration endodontics. Recent work using novel biomaterial scaffolds and growth factors that orchestrate the homing of host endogenous cells represents a departure from traditional cell transplantation approaches and may accelerate clinical translation.

  11. New Regenerative Cycle for Vapor Compression Refrigeration

    Energy Technology Data Exchange (ETDEWEB)

    Mark J. Bergander

    2005-08-29

    The main objective of this project is to confirm on a well-instrumented prototype the theoretically derived claims of higher efficiency and coefficient of performance for geothermal heat pumps based on a new regenerative thermodynamic cycle as comparing to existing technology. In order to demonstrate the improved performance of the prototype, it will be compared to published parameters of commercially available geothermal heat pumps manufactured by US and foreign companies. Other objectives are to optimize the design parameters and to determine the economic viability of the new technology. Background (as stated in the proposal): The proposed technology closely relates to EERE mission by improving energy efficiency, bringing clean, reliable and affordable heating and cooling to the residential and commercial buildings and reducing greenhouse gases emission. It can provide the same amount of heating and cooling with considerably less use of electrical energy and consequently has a potential of reducing our nations dependence on foreign oil. The theoretical basis for the proposed thermodynamic cycle was previously developed and was originally called a dynamic equilibrium method. This theory considers the dynamic equations of state of the working fluid and proposes the methods for modification of T-S trajectories of adiabatic transformation by changing dynamic properties of gas, such as flow rate, speed and acceleration. The substance of this proposal is a thermodynamic cycle characterized by the regenerative use of the potential energy of two-phase flow expansion, which in traditional systems is lost in expansion valves. The essential new features of the process are: (1) The application of two-step throttling of the working fluid and two-step compression of its vapor phase. (2) Use of a compressor as the initial step compression and a jet device as a second step, where throttling and compression are combined. (3) Controlled ratio of a working fluid at the first and

  12. Iron serves as diffusion barrier in thermally regenerative galvanic cell

    Science.gov (United States)

    Crouthamel, C. E.

    1967-01-01

    Pure iron or iron-coated diaphragm provides a hydrogen diffusion electrode for a thermally regenerative galvanic cell. It allows the gas to diffuse through its interatomic spaces and resists the corrosive action of the cell environment.

  13. Advanced Space Power Systems (ASPS): Regenerative Fuel Cells (RFC) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of the regenerative fuel cell project element is to develop power and energy storage technologies that enable new capabilities for future human space...

  14. LOX/Methane Regeneratively-Cooled Rocket Engine Development Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Design, build, and test a 5,000 lbf thrust regeneratively cooled combustion chamber at JSC for a low pressure liquid oxygen/methane engine. The engine demonstrates...

  15. Electrolyzer for NASA Lunar Regenerative Fuel Cells Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Water electrolyzer stacks are a key component of regenerative fuel cells, designed to replace batteries as a means of storing electric energy on the lunar surface....

  16. Platelet-rich fibrin: a boon in regenerative endodontics.

    Science.gov (United States)

    Rebentish, Priyanka D; Umashetty, Girish; Kaur, Harpreet; Doizode, Trupthi; Kaslekar, Mithun; Chowdhury, Shouvik

    2016-12-01

    Research into regenerative dentistry has contributed momentum to the field of molecular biology. Periapical surgery aims at removing periapical pathology to achieve complete wound healing and regeneration of bone and periodontal tissue. Regenerative endodontic procedures are widely being added to the current armamentarium of pulp therapy procedures. The regenerative potential of platelets has been deliberated. Platelet-rich fibrin (PRF) is a wonderful tissue-engineering product and has recently gained much popularity due its promising results in wound healing bone induction. The features of this product are an attribute of platelets which, after cellular interactions, release growth factors and have shown application in diverse disciplines of dentistry. This paper is intended to shed light onto the various prospects of PRF and to provide clinical insight into regenerative endodontic therapy.

  17. Ultralightweight, Regeneratively Cooled Combustion Chamber for Mars Ascent Vehicles Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose a high-pressure, regeneratively-cooled combustion chamber that uses novel material selection for extreme reductions in mass. These materials are...

  18. Advancing pig cloning technologies towards application in regenerative medicine.

    Science.gov (United States)

    Nagashima, H; Matsunari, H; Nakano, K; Watanabe, M; Umeyama, K; Nagaya, M

    2012-08-01

    Regenerative medicine is expected to make a significant contribution by development of novel therapeutic treatments for intractable diseases and for improving the quality of life of patients. Many advances in regenerative medicine, including basic and translational research, have been developed and tested in experimental animals; pigs have played an important role in various aspects of this work. The value of pigs as a model species is being enhanced by the generation of specially designed animals through cloning and genetic modifications, enabling more sophisticated research to be performed and thus accelerating the clinical application of regenerative medicine. This article reviews the significant aspects of the creation and application of cloned and genetically modified pigs in regenerative medicine research and considers the possible future directions of the technology. We also discuss the importance of reproductive biology as an interface between basic science and clinical medicine.

  19. From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells.

    Science.gov (United States)

    Xiao, Li; Nasu, Masanori

    2014-01-01

    Adult mesenchymal stem cells (MSCs) and epithelial stem cells play essential roles in tissue repair and self-healing. Oral MSCs and epithelial stem cells can be isolated from adult human oral tissues, for example, teeth, periodontal ligament, and gingiva. Cocultivated adult oral epithelial stem cells and MSCs could represent some developmental events, such as epithelial invagination and tubular structure formation, signifying their potentials for tissue regeneration. Oral epithelial stem cells have been used in regenerative medicine over 1 decade. They are able to form a stratified cell sheet under three-dimensional culture conditions. Both experimental and clinical data indicate that the cell sheets can not only safely and effectively reconstruct the damaged cornea in humans, but also repair esophageal ulcer in animal models. Oral MSCs include dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHED), stem cells from apical papilla (SCAP), periodontal ligament stem cells (PDLSCs), and mesenchymal stem cells from gingiva (GMSCs). They are widely applied in both regenerative dentistry and medicine. DPSCs, SHED, and SCAP are able to form dentin-pulp complex when being transplanted into immunodeficient animals. They have been experimentally used for the regeneration of dental pulp, neuron, bone muscle and blood vessels in animal models and have shown promising results. PDLSCs and GMSCs are demonstrated to be ideal cell sources for repairing the damaged tissues of periodontal, muscle, and tendon. Despite the abovementioned applications of oral stem cells, only a few human clinical trials are now underway to use them for the treatment of certain diseases. Since clinical use is the end goal, their true regenerative power and safety need to be further examined.

  20. From regenerative dentistry to regenerative medicine: progress, challenges, and potential applications of oral stem cells

    Directory of Open Access Journals (Sweden)

    Xiao L

    2014-12-01

    Full Text Available Li Xiao,1 Masanori Nasu2 1Department of Pharmacology, 2Research Center, The Nippon Dental University, Tokyo, Japan Abstract: Adult mesenchymal stem cells (MSCs and epithelial stem cells play essential roles in tissue repair and self-healing. Oral MSCs and epithelial stem cells can be isolated from adult human oral tissues, for example, teeth, periodontal ligament, and gingiva. Cocultivated adult oral epithelial stem cells and MSCs could represent some developmental events, such as epithelial invagination and tubular structure formation, signifying their potentials for tissue regeneration. Oral epithelial stem cells have been used in regenerative medicine over 1 decade. They are able to form a stratified cell sheet under three-dimensional culture conditions. Both experimental and clinical data indicate that the cell sheets can not only safely and effectively reconstruct the damaged cornea in humans, but also repair esophageal ulcer in animal models. Oral MSCs include dental pulp stem cells (DPSCs, stem cells from exfoliated deciduous teeth (SHED, stem cells from apical papilla (SCAP, periodontal ligament stem cells (PDLSCs, and mesenchymal stem cells from gingiva (GMSCs. They are widely applied in both regenerative dentistry and medicine. DPSCs, SHED, and SCAP are able to form dentin–pulp complex when being transplanted into immunodeficient animals. They have been experimentally used for the regeneration of dental pulp, neuron, bone muscle and blood vessels in animal models and have shown promising results. PDLSCs and GMSCs are demonstrated to be ideal cell sources for repairing the damaged tissues of periodontal, muscle, and tendon. Despite the abovementioned applications of oral stem cells, only a few human clinical trials are now underway to use them for the treatment of certain diseases. Since clinical use is the end goal, their true regenerative power and safety need to be further examined.Keywords: oral mesenchymal stem cells, oral

  1. Soy Protein Scaffold Biomaterials for Tissue Engineering and Regenerative Medicine

    Science.gov (United States)

    Chien, Karen B.

    Developing functional biomaterials using highly processable materials with tailorable physical and bioactive properties is an ongoing challenge in tissue engineering. Soy protein is an abundant, natural resource with potential use for regenerative medicine applications. Preliminary studies show that soy protein can be physically modified and fabricated into various biocompatible constructs. However, optimized soy protein structures for tissue regeneration (i.e. 3D porous scaffolds) have not yet been designed. Furthermore, little work has established the in vivo biocompatibility of implanted soy protein and the benefit of using soy over other proteins including FDA-approved bovine collagen. In this work, freeze-drying and 3D printing fabrication processes were developed using commercially available soy protein to create porous scaffolds that improve cell growth and infiltration compared to other soy biomaterials previously reported. Characterization of scaffold structure, porosity, and mechanical/degradation properties was performed. In addition, the behavior of human mesenchymal stem cells seeded on various designed soy scaffolds was analyzed. Biological characterization of the cell-seeded scaffolds was performed to assess feasibility for use in liver tissue regeneration. The acute and humoral response of soy scaffolds implanted in an in vivo mouse subcutaneous model was also investigated. All fabricated soy scaffolds were modified using thermal, chemical, and enzymatic crosslinking to change properties and cell growth behavior. 3D printing allowed for control of scaffold pore size and geometry. Scaffold structure, porosity, and degradation rate significantly altered the in vivo response. Freeze-dried soy scaffolds had similar biocompatibility as freeze-dried collagen scaffolds of the same protein content. However, the soy scaffolds degraded at a much faster rate, minimizing immunogenicity. Interestingly, subcutaneously implanted soy scaffolds affected blood

  2. Regenerative Capacity of Macrophages for Remyelination

    Directory of Open Access Journals (Sweden)

    Khalil eRawji

    2016-05-01

    Full Text Available White matter injury, consisting of loss of axons, myelin and oligodendrocytes, is common in many neurological disorders and is believed to underlie several motor and sensory deficits. Remyelination is the process in which the insulative myelin sheath is restored to axons, thereby facilitating recovery from functional loss. Remyelination proceeds with oligodendrocyte precursor cells that differentiate into oligodendrocytes to synthesize the new myelin sheath after demyelination. This process is influenced by several factors, including trophic factors, inhibitory molecules in the lesion microenvironment, age of the subject, as well as the inflammatory response. Currently studied strategies that enhance remyelination consist of pharmacological approaches that directly induce oligodendrocyte precursor cell differentiation or using agents to neutralize the inhibitory microenvironment. Another strategy is to harness a reparative inflammatory response. This response, coordinated by central nervous system resident microglia and peripherally-derived infiltrating macrophages, has been shown to be important in the remyelination process. These innate immune cells perform important functions in remyelination, including the proteolysis and phagocytosis of inhibitory molecules present in the lesion microenvironment, the provision of trophic and metabolic factors to oligodendrocyte precursor cells, in addition to iron handling capacity. Additionally, an initial pro-inflammatory phase followed by a regulatory/anti-inflammatory phase has been shown to be important for oligodendrocyte precursor cell proliferation and differentiation, respectively. This review will discuss the beneficial roles of macrophages/microglia in remyelination and discuss therapeutic strategies to obtain the optimal regenerative macrophage phenotype for enhanced remyelination.

  3. Introduction to stem cells and regenerative medicine.

    Science.gov (United States)

    Kolios, George; Moodley, Yuben

    2013-01-01

    Stem cells are a population of undifferentiated cells characterized by the ability to extensively proliferate (self-renewal), usually arise from a single cell (clonal), and differentiate into different types of cells and tissue (potent). There are several sources of stem cells with varying potencies. Pluripotent cells are embryonic stem cells derived from the inner cell mass of the embryo and induced pluripotent cells are formed following reprogramming of somatic cells. Pluripotent cells can differentiate into tissue from all 3 germ layers (endoderm, mesoderm, and ectoderm). Multipotent stem cells may differentiate into tissue derived from a single germ layer such as mesenchymal stem cells which form adipose tissue, bone, and cartilage. Tissue-resident stem cells are oligopotent since they can form terminally differentiated cells of a specific tissue. Stem cells can be used in cellular therapy to replace damaged cells or to regenerate organs. In addition, stem cells have expanded our understanding of development as well as the pathogenesis of disease. Disease-specific cell lines can also be propagated and used in drug development. Despite the significant advances in stem cell biology, issues such as ethical controversies with embryonic stem cells, tumor formation, and rejection limit their utility. However, many of these limitations are being bypassed and this could lead to major advances in the management of disease. This review is an introduction to the world of stem cells and discusses their definition, origin, and classification, as well as applications of these cells in regenerative medicine.

  4. REGENERATIVE MEDICINE AS APPLIED TO GENERAL SURGERY

    Science.gov (United States)

    Orlando, Giuseppe; Wood, Kathryn J; De Coppi, Paolo; Baptista, Pedro M; Binder, Kyle W; Bitar, Khalil N; Breuer, Christopher; Burnett, Luke; Christ, George; Farney, Alan; Figliuzzi, Marina; Holmes, James H; Koch, Kenneth; Macchiarini, Paolo; Sani, Sayed-Hadi Mirmalek; Opara, Emmanuel; Remuzzi, Andrea; Rogers, Jeffrey; Saul, Justin M; Seliktar, Dror; Shapira-Schweitzer, Keren; Smith, Tom; Solomon, Daniel; Van Dyke, Mark; Yoo, James J; Zhang, Yuanyuan; Atala, Anthony; Stratta, Robert J; Soker, Shay

    2012-01-01

    The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues or organs in order to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery. The main challenges for investigators are threefold: Creation of an appropriate microenvironment ex vivo that is able to sustain cell physiology and function in order to generate the desired cells or body parts; identification and appropriate manipulation of cells that have the potential to generate parenchymal, stromal and vascular components on demand, both in vivo and ex vivo; and production of smart materials that are able to drive cell fate. PMID:22330032

  5. High power, high beam quality regenerative amplifier

    Science.gov (United States)

    Hackel, L.A.; Dane, C.B.

    1993-08-24

    A regenerative laser amplifier system generates high peak power and high energy per pulse output beams enabling generation of X-rays used in X-ray lithography for manufacturing integrated circuits. The laser amplifier includes a ring shaped optical path with a limited number of components including a polarizer, a passive 90 degree phase rotator, a plurality of mirrors, a relay telescope, and a gain medium, the components being placed close to the image plane of the relay telescope to reduce diffraction or phase perturbations in order to limit high peak intensity spiking. In the ring, the beam makes two passes through the gain medium for each transit of the optical path to increase the amplifier gain to loss ratio. A beam input into the ring makes two passes around the ring, is diverted into an SBS phase conjugator and proceeds out of the SBS phase conjugator back through the ring in an equal but opposite direction for two passes, further reducing phase perturbations. A master oscillator inputs the beam through an isolation cell (Faraday or Pockels) which transmits the beam into the ring without polarization rotation. The isolation cell rotates polarization only in beams proceeding out of the ring to direct the beams out of the amplifier. The diffraction limited quality of the input beam is preserved in the amplifier so that a high power output beam having nearly the same diffraction limited quality is produced.

  6. Translating Regenerative Biomaterials Into Clinical Practice.

    Science.gov (United States)

    Stace, Edward T; Dakin, Stephanie G; Mouthuy, Pierre-Alexis; Carr, Andrew J

    2016-01-01

    Globally health care spending is increasing unsustainably. This is especially true of the treatment of musculoskeletal (MSK) disease where in the United States the MSK disease burden has doubled over the last 15 years. With an aging and increasingly obese population, the surge in MSK related spending is only set to worsen. Despite increased funding, research and attention to this pressing health need, little progress has been made toward novel therapies. Tissue engineering and regenerative medicine (TERM) strategies could provide the solutions required to mitigate this mounting burden. Biomaterial-based treatments in particular present a promising field of potentially cost-effective therapies. However, the translation of a scientific development to a successful treatment is fraught with difficulties. These barriers have so far limited translation of TERM science into clinical treatments. It is crucial for primary researchers to be aware of the barriers currently restricting the progression of science to treatments. Researchers need to act prospectively to ensure the clinical, financial, and regulatory hurdles which seem so far removed from laboratory science do not stall or prevent the subsequent translation of their idea into a treatment. The aim of this review is to explore the development and translation of new treatments. Increasing the understanding of these complexities and barriers among primary researchers could enhance the efficiency of biomaterial translation. © 2015 Wiley Periodicals, Inc.

  7. Bioactive nanofibrous scaffolds for regenerative endodontics.

    Science.gov (United States)

    Bottino, M C; Kamocki, K; Yassen, G H; Platt, J A; Vail, M M; Ehrlich, Y; Spolnik, K J; Gregory, R L

    2013-11-01

    Here we report the synthesis, materials characterization, antimicrobial capacity, and cytocompatibility of novel antibiotic-containing scaffolds. Metronidazole (MET) or Ciprofloxacin/(CIP) was mixed with a polydioxanone (PDS)polymer solution at 5 and 25 wt% and processed into fibers. PDS fibers served as a control. Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), tensile testing, and high-performance liquid chromatography (HPLC) were used to assess fiber morphology, chemical structure, mechanical properties, and drug release, respectively. Antimicrobial properties were evaluated against those of Porphyromonas gingivalis/Pg and Enterococcus faecalis/Ef. Cytotoxicity was assessed in human dental pulp stem cells (hDPSCs). Statistics were performed, and significance was set at the 5% level. SEM imaging revealed a submicron fiber diameter. FTIR confirmed antibiotic incorporation. The tensile values of hydrated 25 wt% CIP scaffold were significantly lower than those of all other groups. Analysis of HPLC data confirmed gradual, sustained drug release from the scaffolds over 48 hrs. CIP-containing scaffolds significantly (p regenerative endodontics.

  8. Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes

    Science.gov (United States)

    Bruna, Flavia; Contador, David; Conget, Paulette; Erranz, Benjamín; Sossa, Claudia L.; Arango-Rodríguez, Martha L.

    2016-01-01

    Preclinical and clinical studies have shown that a therapeutic effect results from mesenchymal stromal cells (MSCs) transplant. No systematic information is currently available regarding whether donor age modifies MSC regenerative potential on cutaneous wound healing. Here, we evaluate whether donor age influences this potential. Two different doses of bone marrow MSCs (BM-MSCs) from young, adult, or old mouse donors or two doses of their acellular derivatives mesenchymal stromal cells (acd-MSCs) were intradermally injected around wounds in the midline of C57BL/6 mice. Every two days, wound healing was macroscopically assessed (wound closure) and microscopically assessed (reepithelialization, dermal-epidermal junction, skin appendage regeneration, granulation tissue, leukocyte infiltration, and density dermal collagen fibers) after 12 days from MSC transplant. Significant differences in the wound closure kinetic, quality, and healing of skin regenerated were observed in lesions which received BM-MSCs from different ages or their acd-MSCs compared to lesions which received vehicle. Nevertheless, our data shows that adult's BM-MSCs or their acd-MSCs were the most efficient for recovery of most parameters analyzed. Our data suggest that MSC efficacy was negatively affected by donor age, where the treatment with adult's BM-MSCs or their acd-MSCs in cutaneous wound promotes a better tissue repair/regeneration. This is due to their paracrine factors secretion. PMID:27247575

  9. The regenerative effect of catalyst fluidization under methanation conditions

    Energy Technology Data Exchange (ETDEWEB)

    Seemann, M.C.; Schildhauer, T.J.; Biollaz, S.M.A.; Stucki, S.; Wokaun, A. [Laboratory of Energy and Materials Cycles, Thermal Process Engineering, Paul Scherrer Institut, CH-5232 Villigen PSI (Switzerland)

    2006-09-25

    The regenerative effect of fluidization on catalysts in methanation reactors was shown by in situ measurements of the axial gas phase concentration profiles. The profiles prove strong carbon exchange processes between the catalyst and the gas phase. These exchange processes structure the bed into three zones: carbon deposition, predominantly by CO dissociation, at the inlet; predominant gasification of solid carbon species from the catalyst in the following zone, and predominant carbon deposition by methane dissociation in the upper part of the bed. By analyzing the carbon-balance, locally up to 20% excess carbon was found in the gas phase, mainly in form of methane. The excess methane decomposes again, forming less reactive carbon with a slow rate. Due to an intensive catalyst mixing, the build-up of unreactive carbon can be prevented by regeneration in the middle zone of the reactor. As these processes are influenced by the particle movement, conclusions about regions of up- and down-flow of the catalyst particles can be drawn. (author)

  10. Musculoskeletal Regenerative Engineering: Biomaterials, Structures, and Small Molecules

    OpenAIRE

    Roshan James; Laurencin, Cato T.

    2014-01-01

    Musculoskeletal tissues are critical to the normal functioning of an individual and following damage or degeneration they show extremely limited endogenous regenerative capacity. The future of regenerative medicine is the combination of advanced biomaterials, structures, and cues to re-engineer/guide stem cells to yield the desired organ cells and tissues. Tissue engineering strategies were ideally suited to repair damaged tissues; however, the substitution and regeneration of large tissue vo...

  11. Portable vibration exciter

    Science.gov (United States)

    Beecher, L. C.; Williams, F. T.

    1970-01-01

    Gas-driven vibration exciter produces a sinusoidal excitation function controllable in frequency and in amplitude. It allows direct vibration testing of components under normal loads, removing the possibility of component damage due to high static pressure.

  12. Control System Damps Vibrations

    Science.gov (United States)

    Kopf, E. H., Jr.; Brown, T. K.; Marsh, E. L.

    1983-01-01

    New control system damps vibrations in rotating equipment with help of phase-locked-loop techniques. Vibrational modes are controlled by applying suitable currents to drive motor. Control signals are derived from sensors mounted on equipment.

  13. Manufacturing road map for tissue engineering and regenerative medicine technologies.

    Science.gov (United States)

    Hunsberger, Joshua; Harrysson, Ola; Shirwaiker, Rohan; Starly, Binil; Wysk, Richard; Cohen, Paul; Allickson, Julie; Yoo, James; Atala, Anthony

    2015-02-01

    The Regenerative Medicine Foundation Annual Conference held on May 6 and 7, 2014, had a vision of assisting with translating tissue engineering and regenerative medicine (TERM)-based technologies closer to the clinic. This vision was achieved by assembling leaders in the field to cover critical areas. Some of these critical areas included regulatory pathways for regenerative medicine therapies, strategic partnerships, coordination of resources, developing standards for the field, government support, priorities for industry, biobanking, and new technologies. The final day of this conference featured focused sessions on manufacturing, during which expert speakers were invited from industry, government, and academia. The speakers identified and accessed roadblocks plaguing the field where improvements in advanced manufacturing offered many solutions. The manufacturing sessions included (a) product development toward commercialization in regenerative medicine, (b) process challenges to scale up manufacturing in regenerative medicine, and (c) infrastructure needs for manufacturing in regenerative medicine. Subsequent to this, industry was invited to participate in a survey to further elucidate the challenges to translation and scale-up. This perspective article will cover the lessons learned from these manufacturing sessions and early results from the survey. We also outline a road map for developing the manufacturing infrastructure, resources, standards, capabilities, education, training, and workforce development to realize the promise of TERM.

  14. Initiation of limb regeneration: the critical steps for regenerative capacity.

    Science.gov (United States)

    Yokoyama, Hitoshi

    2008-01-01

    While urodele amphibians (newts and salamanders) can regenerate limbs as adults, other tetrapods (reptiles, birds and mammals) cannot and just undergo wound healing. In adult mammals such as mice and humans, the wound heals and a scar is formed after injury, while wound healing is completed without scarring in an embryonic mouse. Completion of regeneration and wound healing takes a long time in regenerative and non-regenerative limbs, respectively. However, it is the early steps that are critical for determining the extent of regenerative response after limb amputation, ranging from wound healing with scar formation, scar-free wound healing, hypomorphic limb regeneration to complete limb regeneration. In addition to the accumulation of information on gene expression during limb regeneration, functional analysis of signaling molecules has recently shown important roles of fibroblast growth factor (FGF), Wnt/beta-catenin and bone morphogenic protein (BMP)/Msx signaling. Here, the routine steps of wound healing/limb regeneration and signaling molecules specifically involved in limb regeneration are summarized. Regeneration of embryonic mouse digit tips and anuran amphibian (Xenopus) limbs shows intermediate regenerative responses between the two extremes, those of adult mammals (least regenerative) and urodele amphibians (more regenerative), providing a range of models to study the various abilities of limbs to regenerate.

  15. Study on Integrated Thermal Cycle and Vibration Profile for HALT

    Institute of Scientific and Technical Information of China (English)

    TAO Jun-yong; CHU Wei-hua; CHEN Xun

    2009-01-01

    Focusing on electronic products, this paper establishes a finite element model for printed circuit board (PCB) assembling with enhanced ball grid array(EBGA)component under vibration environment. Based on this model, it studies relations between fatigue rate of solder joint and temperature, vibration frequency. Moreover, it analyzes propagation of micro-crack produced by thermal cycle under vibration stress. The results offer a method to optimize the thermal cycle and vibration integrated profile and to combine vibration test and thermal cycling for highly accelerated life test (HALT).

  16. Distinguishing clinical and imaging features of nodular regenerative hyperplasia and large regenerative nodules of the liver

    Energy Technology Data Exchange (ETDEWEB)

    Ames, J.T. [Departments of Radiology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania (United States); Federle, M.P., E-mail: federle@stanford.ed [Departments of Radiology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania (United States); Chopra, K. [Departments of Gastroenterology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania (United States)

    2009-12-15

    Aim: Nodular regenerative hyperplasia (NRH) and large regenerative nodules (LRN) are distinct types of hepatocellular nodules that have been confused in the radiology literature. However, distinction is critical because their clinical significance is quite different. Our purpose was to review the clinical and imaging findings in a series of patients with NRH and LRN in order to identify distinguishing clinical and imaging features. Materials and methods: This was a retrospective case series. The clinical and imaging features were compared in 36 patients with pathological proof of NRH and 23 patients with pathological evidence of LRN. Results: NRH and LRN have different predisposing factors and imaging findings. NRH is often associated with organ transplantation, myeloproliferative disease, or autoimmune processes. Livers with NRH typically do not have enhancing nodules; none of the present patients with NRH had enhancing liver masses. In contrast, LRN are often associated with Budd-Chiari syndrome. Enhancing liver masses were noted in 19 (83%) of the 23 patients with LRN. The p values for the comparisons were less than 0.001 for both enhancing liver masses and hepatic vein thrombosis. Conclusion: NRH and LRN can have distinct clinical presentations and imaging appearances. LRN often result in enhancing liver nodules, whereas NRH usually does not. Clinical and imaging information enables the distinction of LRN and NRH in many cases.

  17. Vibration Measurement with PULSE and DSPACE Equipment

    Directory of Open Access Journals (Sweden)

    Radim KLEČKA

    2009-06-01

    Full Text Available This contribution describes techniques and results of measurement with TIRA vibration generator. A method of experimental modal analysis allows next restore of vibration data. The goal is check validity of head expanders and screw connection. This process is based to using ME’scope environment. Another goal is check possibilities of dSPACE platform to vibration measurement. This task includes design of connection between dSPACE system and power amplifier, creating of graphical user interface and analyzing main configuration parameters to improve quality of drive signal.

  18. Windowed defocused photographic speckle vibration measurement

    CERN Document Server

    Diazdelacruz, Jose M

    2014-01-01

    The out-of-plane vibration of a rough surface causes an in-plane vibration of its speckle pattern when observed with a defocused optical photographic system. If the frequency of the oscillations is high enough, a time-averaged specklegram is recorded from which the amplitude of the vibration can be estimated. The statistical character of speckle distributions along with the pixel sampling and intensity analog-to-digital conversion inherent to electronic cameras degrade the accuracy of the amplitude measurement to an extent that is analyzed and experimentally tested in this paper. The relations limiting the mutually competing metrological features of a defocused speckle system are also deduced mathematically.

  19. Platelet derivatives in regenerative medicine: an update.

    Science.gov (United States)

    De Pascale, Maria Rosaria; Sommese, Linda; Casamassimi, Amelia; Napoli, Claudio

    2015-01-01

    Prior preclinical and clinical studies support the use of platelet-derived products for the treatment of soft and hard tissue lesions. These regenerative effects are controlled by autocrine and paracrine biomolecules including growth factors and cytokines contained in platelet alpha granules. Each growth factor is involved in a phase of the healing process, such as inflammation, collagen synthesis, tissue granulation, and angiogenesis collectively promoting tissue restitution. Platelet derivatives have been prepared as platelet-rich plasma, platelet gel, platelet-rich fibrin, and platelet eye drops. These products vary in their structure, growth factors, composition, and cytokine concentrations. Here, we review the current use of platelet-derived biological products focusing on the rationale for their use and the main requirements for their preparation. Variation in the apparent therapeutic efficacy may have resulted from a lack of reproducible, standardized protocols for preparation. Despite several individual studies showing favorable treatment effects, some randomized controlled trials as well as meta-analyses have found no constant clinical benefit from the application of platelet-derived products for prevention of tissue lesions. Recently, 3 published studies in dentistry showed an improvement in bone density. Seven published studies showed positive results in joint regeneration. Five published studies demonstrated an improvement in the wound healing, and an improvement of eye epithelial healing was observed in 2 reports. Currently, at least 14 ongoing clinical trials in phase 3 or 4 have been designed with large groups of treated patients (n > 100). Because the rationale of the therapy with platelet-derived compounds is still debated, a definitive insight can be acquired only when these large randomized trials will be completed.

  20. Analysis of sensitivity and errors in Maglev vibration test system

    Institute of Scientific and Technical Information of China (English)

    JIANG; Dong; LIU; Xukun; WANG; Deyu; YANG; Jiaxiang

    2016-01-01

    In order to improve work performance of M aglev vibration test systems,the relationships of operating parameters between different components and system were researched. The working principle of photoelectric displacement sensor was analyzed. The relationship between displacement of transducer and the infrared light area received by sensor was given. The method of expanding the dynamic range of vibrator was proposed,which makes dynamic range of Maglev vibrator doubled. By increasing the amplification of the amplifier,the sensitive photoelectric displacement sensor can be maintained. Two modes of operation of the controller were analyzed. Bilateral work of vibration test system designed can further improve the stability of the system.An object vibration was measured by Maglev vibration test system designed when different vibration exciter frequencies were loaded. Experiments showthat the output frequency measured by Maglev vibration test system and loaded are the same. Finally,the errors of test system were analyzed. These errors of vibration test system designed can meet the requirements of application. The results laid the foundation for the practical application of magnetic levitation vibration test system.

  1. Stem Cells Applications in Regenerative Medicine and Disease Therapeutics

    Directory of Open Access Journals (Sweden)

    Ranjeet Singh Mahla

    2016-01-01

    Full Text Available Regenerative medicine, the most recent and emerging branch of medical science, deals with functional restoration of tissues or organs for the patient suffering from severe injuries or chronic disease. The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by conventional medicines. The indefinite self-renewal and potential to differentiate into other types of cells represent stem cells as frontiers of regenerative medicine. The transdifferentiating potential of stem cells varies with source and according to that regenerative applications also change. Advancements in gene editing and tissue engineering technology have endorsed the ex vivo remodelling of stem cells grown into 3D organoids and tissue structures for personalized applications. This review outlines the most recent advancement in transplantation and tissue engineering technologies of ESCs, TSPSCs, MSCs, UCSCs, BMSCs, and iPSCs in regenerative medicine. Additionally, this review also discusses stem cells regenerative application in wildlife conservation.

  2. Stem cells have the potential to rejuvenate regenerative medicine research.

    Science.gov (United States)

    Eve, David J; Fillmore, Randolph; Borlongan, Cesar V; Sanberg, Paul R

    2010-10-01

    The increasing number of publications featuring the use of stem cells in regenerative processes supports the idea that they are revolutionizing regenerative medicine research. In an analysis of the articles published in the journal Cell Transplantation - The Regenerative Medicine Journal between 2008 and 2009, which reveals the topics and categories that are on the cutting edge of regenerative medicine research, stem cells are becoming increasingly relevant as the "runner-up" category to "neuroscience" related articles. The high volume of stem cell research casts a bright light on the hope for stem cells and their role in regenerative medicine as a number of reports deal with research using stem cells entering, or seeking approval for, clinical trials. The "methods and new technologies" and "tissue engineering" sections were almost equally as popular, and in part, reflect attempts to maximize the potential of stem cells and other treatments for the repair of damaged tissue. Transplantation studies were again more popular than non-transplantation, and the contribution of stem cell-related transplants was greater than other types of transplants. The non-transplantation articles were predominantly related to new methods for the preparation, isolation and manipulation of materials for transplant by specific culture media, gene therapy, medicines, dietary supplements, and co-culturing with other cells and further elucidation of disease mechanisms. A sizeable proportion of the transplantation articles reported on how previously new methods may have aided the ability of the cells or tissue to exert beneficial effects following transplantation.

  3. Rethinking Regenerative Medicine: A Macrophage-Centered Approach

    Directory of Open Access Journals (Sweden)

    Bryan N Brown

    2014-11-01

    Full Text Available Regenerative medicine, a multi-disciplinary approach that seeks to restore form and function to damaged or diseased tissues and organs, has evolved significantly during the past decade. By adapting and integrating fundamental knowledge from cell biology, polymer science, and engineering, coupled with an increasing understanding of the mechanisms which underlie the pathogenesis of specific diseases, regenerative medicine has the potential for innovative and transformative therapies for heretofore unmet medical needs. However, the translation of novel technologies from the benchtop to animal models and clinical settings is non-trivial and requires an understanding of the mechanisms by which the host will respond to these novel therapeutic approaches. The role of the innate immune system, especially the role of macrophages, in the host response to regenerative medicine based strategies has recently received considerable attention. Macrophage phenotype and function have been suggested as critical and determinant factors in downstream functional outcomes. The constructive and regulatory, and in fact essential, role of macrophages in positive outcomes represents a significant departure from the classical paradigms of host-biomaterial interactions, which typically consider activation of the host immune system as undesirable. It appears desirable that emerging regenerative medicine approaches should not only accommodate, but promote, the involvement of the immune system to facilitate positive outcomes. Herein, we describe the current understanding of macrophage phenotype as it pertains to regenerative medicine and suggest that improvement of our understanding of context-dependent macrophage polarization will lead to concurrent improvement in outcomes.

  4. An Intelligent Regenerative Braking Strategy for Electric Vehicles

    Directory of Open Access Journals (Sweden)

    Zhibin Song

    2011-09-01

    Full Text Available Regenerative braking is an effective approach for electric vehicles (EVs to extend their driving range. A fuzzy-logic-based regenerative braking strategy (RBS integrated with series regenerative braking is developed in this paper to advance the level of energy-savings. From the viewpoint of securing car stability in braking operations, the braking force distribution between the front and rear wheels so as to accord with the ideal distribution curve are considered to prevent vehicles from experiencing wheel lock and slip phenomena during braking. Then, a fuzzy RBS using the driver’s braking force command, vehicle speed, battery SOC, battery temperature are designed to determine the distribution between friction braking force and regenerative braking force to improve the energy recuperation efficiency. The experimental results on an “LF620” prototype EV validated the feasibility and effectiveness of regenerative braking and showed that the proposed fuzzy RBS was endowed with good control performance. The maximum driving range of LF620 EV was improved by 25.7% compared with non-RBS conditions.

  5. Exergy Analysis and Second Law Efficiency of a Regenerative Brayton Cycle with Isothermal Heat Addition

    Directory of Open Access Journals (Sweden)

    Naser M. Jubeh

    2005-07-01

    Full Text Available Abstract: The effect of two heat additions, rather than one, in a gas turbine engine is analyzed from the second law of thermodynamics point of view. A regenerative Brayton cycle model is used for this study, and compared with other models of Brayton cycle. All fluid friction losses in the compressor and turbine are quantified by an isentropic efficiency term. The effect of pressure ratio, turbine inlet temperature, ambient temperature, altitude, and altitude with variable ambient temperature on irreversibility "exergy destroyed" and second law efficiency was investigated and compared for all models. The results are given graphically with the appropriate discussion and conclusion.

  6. Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds

    Directory of Open Access Journals (Sweden)

    Vanesa Andreu

    2015-08-01

    the beneficial or inert effects of those natural origin occurring materials, the scientific community leads towards the identification of the main active components involved and their mechanism of action during the corresponding healing, antimicrobial, or regenerative processes and in carrying out systematic and comparative controlled tests. Once those natural origin components have been identified and their efficacy validated through solid clinical trials, their combination within nanostructured dressings can open up new avenues in the fabrication of bioactive dressings with outstanding characteristics for wound care. The motivation of this work is to analyze the state of the art in the use of different essential oils, honey, cationic peptides, aloe vera, plant extracts, and other natural origin occurring materials as antimicrobial, anti-inflammatory and regenerative components with the aim of clarifying their potential clinical use in bioactive dressings. We conclude that, for those natural occurring materials, more clinical trials are needed to reach a sufficient level of evidence as therapeutic agents for wound healing management.

  7. Vibration Transmission in a Multi-Storey Lightweight Building

    DEFF Research Database (Denmark)

    Niu, Bin; Andersen, Lars Vabbersgaard; Kiel, Nikolaj

    2012-01-01

    This paper develops a parametric modelling and analysis approach to investigate the vibration transmission in lightweight buildings. The main focus of the research is to investigate the influence of geometry and configuration of the building on the vibration transmission. A building with a single...... to investigate the transmission of vibration. The influence of different excitation frequencies on the vibration transmission is studied and discussed. The vibration response in two different receiving rooms, one near the source and one far from the source, is illustrated and discussed for the various geometric...... in vibration transmission in a building. The influence on the flanking transmission of introducing a neighbouring room in the direction along the building or on top of the building is discussed. •The vibration transmission in buildings with different room sizes is analyzed and discussed. Based on the parameter...

  8. Thermal Vibrational Convection

    Science.gov (United States)

    Gershuni, G. Z.; Lyubimov, D. V.

    1998-08-01

    Recent increasing awareness of the ways in which vibrational effects can affect low-gravity experiments have renewed interest in the study of thermal vibrational convection across a wide range of fields. For example, in applications where vibrational effects are used to provide active control of heat and mass transfer, such as in heat exchangers, stirrers, mineral separators and crystal growth, a sound understanding of the fundamental theory is required. In Thermal Vibrational Convection, the authors present the theory of vibrational effects caused by a static gravity field, and of fluid flows which appear under vibration in fluid-filled cavities. The first part of the book discusses fluid-filled cavities where the fluid motion only appears in the presence of temperature non-uniformities, while the second considers those situations where the vibrational effects are caused by a non-uniform field. Throughout, the authors concentrate on consideration of high frequency vibrations, where averaging methods can be successfully applied in the study of the phenomena. Written by two of the pioneers in this field, Thermal Vibrational Convection will be of great interest to scientists and engineers working in the many areas that are concerned with vibration, and its effect on heat and mass transfer. These include hydrodynamics, hydro-mechanics, low gravity physics and mechanics, and geophysics. The rigorous approach adopted in presenting the theory of this fascinating and highly topical area will facilitate a greater understanding of the phenomena involved, and will lead to the development of more and better-designed experiments.

  9. Nonlinear Response of Vibrational Conveyers with Nonideal Vibration Exciter: Superharmonic and Subharmonic Resonance

    Directory of Open Access Journals (Sweden)

    H. Bayıroğlu

    2012-01-01

    Full Text Available Vibrational conveyers with a centrifugal vibration exciter transmit their load based on the jumping method. Common unbalanced-mass driver oscillates the trough. The motion is strictly related to the vibrational parameters. The transition over resonance of a vibratory system, excited by rotating unbalances, is important in terms of the maximum vibrational amplitude produced and the power demand on the drive for the crossover. The mechanical system is driven by the DC motor. In this study, the working ranges of oscillating shaking conveyers with nonideal vibration exciter have been analyzed analytically for superharmonic and subharmonic resonances by the method of multiple scales and numerically. The analytical results obtained in this study agree well with the numerical results.

  10. Analysis of vibration reduction level in an 8/6 switched reluctance machine by active vibration cancellation

    Institute of Scientific and Technical Information of China (English)

    Xu LIU; Zai-ping PAN; Z.Q. ZHU

    2010-01-01

    This paper proposes an analytical model for predicting the maximum vibration reduction level in a four-phase 8/6switched reluctance machine(SRM)by employing active vibration cancellation(AVC),one of the most effective and convenient methods for reducing the vibration and acoustic noise produced by SRMs.Based on the proposed method,the factors that influence the vibration reduction level are analyzed in detail.The relationships between vibration and noise reduction levels at resonance frequency and rotor speed are presented.Moreover,it is shown that a large damping factor will lead to smaller vibration reduction level with AVC while,in contrast,a large resonance frequency will increase the vibration reduction level.Both finite element analyses and experiments were carried out on a prototype 8/6 SRM to validate the proposed method.

  11. Nanotechnology and regenerative therapeutics in plastic surgery: The next frontier.

    Science.gov (United States)

    Tan, Aaron; Chawla, Reema; G, Natasha; Mahdibeiraghdar, Sara; Jeyaraj, Rebecca; Rajadas, Jayakumar; Hamblin, Michael R; Seifalian, Alexander M

    2016-01-01

    The rapid ascent of nanotechnology and regenerative therapeutics as applied to medicine and surgery has seen an exponential rise in the scale of research generated in this field. This is evidenced not only by the sheer volume of papers dedicated to nanotechnology but also in a large number of new journals dedicated to nanotechnology and regenerative therapeutics specifically to medicine and surgery. Aspects of nanotechnology that have already brought benefits to these areas include advanced drug delivery platforms, molecular imaging and materials engineering for surgical implants. Particular areas of interest include nerve regeneration, burns and wound care, artificial skin with nanoelectronic sensors and head and neck surgery. This study presents a review of nanotechnology and regenerative therapeutics, with focus on its applications and implications in plastic surgery.

  12. Nanotechnology and regenerative therapeutics in plastic surgery: The next frontier

    Science.gov (United States)

    Tan, Aaron; Chawla, Reema; Natasha, G; Mahdibeiraghdar, Sara; Jeyaraj, Rebecca; Rajadas, Jayakumar; Hamblin, Michael R.; Seifalian, Alexander M.

    2015-01-01

    Summary The rapid ascent of nanotechnology and regenerative therapeutics as applied to medicine and surgery has seen an exponential rise in the scale of research generated in this field. This is evidenced not only by the sheer volume of papers dedicated to nanotechnology but also in a large number of new journals dedicated to nanotechnology and regenerative therapeutics specifically to medicine and surgery. Aspects of nanotechnology that have already brought benefits to these areas include advanced drug delivery platforms, molecular imaging and materials engineering for surgical implants. Particular areas of interest include nerve regeneration, burns and wound care, artificial skin with nanoelectronic sensors and head and neck surgery. This study presents a review of nanotechnology and regenerative therapeutics, with focus on its applications and implications in plastic surgery. PMID:26422652

  13. Integrated thermal simulation of buildings and regenerative evaporative coolers

    Energy Technology Data Exchange (ETDEWEB)

    Rousseau, P.G.; Mathews, E.H.; Grobler, L.J. (Pretoria Univ. (South Africa). Centre for Experimental and Numerical Thermoflow)

    1994-01-01

    The thermal environment inside a building, fitted with a regenerative evaporative cooler, is influenced by the performance of the cooler. However, this performance is again influenced by the indoor air conditions. It means that the thermal performance of the building and the performance of the cooler cannot be separated. This paper proposes an innovative model for simulating the integrated thermal performance of buildings and regenerative evaporative coolers. The cooler model employs a standard single equation to characterize the performance of a cooler. Only the coefficients of this equation differs for different coolers. These coefficients are found from empirical performance data available from suppliers. The model was integrated with a comprehensive building thermal analysis program and verified successfully. This model now enables the designer to simulate any regenerative evaporative cooler connected to any building in any climatic region. The control strategy best suited for different off-design conditions can now also be investigated. (Author)

  14. Regenerative strategies for the treatment of knee joint disabilities

    CERN Document Server

    Reis, Rui

    2017-01-01

    This book presents regenerative strategies for the treatment of knee joint disabilities. The book is composed of four main sections totaling 19 chapters which review the current knowledge on the clinical management and preclinical regenerative strategies. It examines the role of different natural-based biomaterials as scaffolds and implants for addressing different tissue lesions in the knee joint. Section one provides an updated and comprehensive discussion on articular cartilage tissue regeneration. Section two focuses on the important contributions for bone and osteochondral tissue engineering. Section three overview the recent advances on meniscus repair/regeneration strategies. Finally, section four further discusses the current strategies for treatment of ligament lesions. Each chapter is prepared by world know expert on their fields, so we do firmly believe that the proposed book will be a reference in the area of biomaterials for regenerative medicine.

  15. A practitioner survey of opinions toward regenerative endodontics.

    Science.gov (United States)

    Epelman, Ingrid; Murray, Peter E; Garcia-Godoy, Franklin; Kuttler, Sergio; Namerow, Kenneth N

    2009-09-01

    The success of regenerative endodontic procedures requires practitioner acceptance, but little or no evidence is available. The purpose of this survey was to collect the opinions of attendee's of the 2008 Endodontic Board of Diplomates 2008 Summer Conference on the issue of regenerative endodontic procedures (REPs). After Nova Southeastern University institutional review board approval, 100 copies of a survey were circulated, and 56 completed surveys were returned anonymously. The survey found that 96% of participants thought that more regenerative therapies should be incorporated into treatments. Although only 14% of participants had used umbilical cord or stem cell banking for themselves or a relative, 63% thought that stem cell banking would be useful to regenerate dental tissues. Most (89%) of the participants would be willing to save teeth and dental tissues for stem cell banking. These results suggest that endodontic practitioners are supportive and optimistic about the future use of REPs.

  16. Genetically modified cells in regenerative medicine and tissue engineering.

    Science.gov (United States)

    Sheyn, Dima; Mizrahi, Olga; Benjamin, Shimon; Gazit, Zulma; Pelled, Gadi; Gazit, Dan

    2010-06-15

    Regenerative medicine appears to take as its patron, the Titan Prometheus, whose liver was able to regenerate daily, as the field attempts to restore lost, damaged, or aging cells and tissues. The tremendous technological progress achieved during the last decade in gene transfer methods and imaging techniques, as well as recent increases in our knowledge of cell biology, have opened new horizons in the field of regenerative medicine. Genetically engineered cells are a tool for tissue engineering and regenerative medicine, albeit a tool whose development is fraught with difficulties. Gene-and-cell therapy offers solutions to severe problems faced by modern medicine, but several impediments obstruct the path of such treatments as they move from the laboratory toward the clinical setting. In this review we provide an overview of recent advances in the gene-and-cell therapy approach and discuss the main hurdles and bottlenecks of this approach on its path to clinical trials and prospective clinical practice.

  17. [The prospects for the development of regenerative physical therapy].

    Science.gov (United States)

    Konchugova, T V; Bobrovnitskiĭ, I P; Orekhova, É M; Puzyreva, G A

    2014-01-01

    The review is concerned with the investigations into the influence of physiotherapeutic factors on the regeneration of the muscular, nervous, bone, and epidermal tissues; also, it analyses the publications pertaining to the influence of low-intensive physiotherapeutic modalities on the migration rate, proliferative activity, and differentiation of stem cells as well as physiological stability and viability of these cells following their transplantation. The currently available data give evidence of the possibility in principle of the combined application of physiotherapeutic factors and cellular technologies in regenerative medicine and the prospects opening for the development of the new direction of research in modern biomedicine, namely regenerative physical therapy. The importance of interdisciplinary basic and clinical investigations in this direction becomes especially evident in the light of the recent achievements and rapid progress in the development of modern regenerative medicine.

  18. Gene delivery in tissue engineering and regenerative medicine.

    Science.gov (United States)

    Fang, Y L; Chen, X G; W T, Godbey

    2015-11-01

    As a promising strategy to aid or replace tissue/organ transplantation, gene delivery has been used for regenerative medicine applications to create or restore normal function at the cell and tissue levels. Gene delivery has been successfully performed ex vivo and in vivo in these applications. Excellent proliferation capabilities and differentiation potentials render certain cells as excellent candidates for ex vivo gene delivery for regenerative medicine applications, which is why multipotent and pluripotent cells have been intensely studied in this vein. In this review, gene delivery is discussed in detail, along with its applications to tissue engineering and regenerative medicine. A definition of a stem cell is compared to a definition of a stem property, and both provide the foundation for an in-depth look at gene delivery investigations from a germ lineage angle.

  19. Vibration reduction in electric bus during acceleration and gear shifting

    Directory of Open Access Journals (Sweden)

    Jia-Shiun Chen

    2015-03-01

    Full Text Available Electric vehicles have replaced many gasoline vehicles in urban environments. The magnitude of vibrations and emissions from electric vehicles are less than those from conventional gasoline-powered vehicles. However, electric vehicles still have mechanical vibrations, such as those created by the power system. During vehicle acceleration, driveline vibration is very prominent. This work focuses on vehicle vibration caused by the electric powertrain in electric vehicles under rapid acceleration/deceleration and gear shifting. Since the dynamic response of an electric motor is rapid, driving torsional vibration arising from acceleration/deceleration and gear shifting is typically transmitted from driveline to vehicle’s body, adversely affecting a driver’s comfort. This work presents a novel effective control logic that reduces vibrations from an electric driveline system. This system controls the electric motor to suppress driveline torsional vibration transmitted to the driver’s seat, effectively reducing vertical vibrations and enhancing driver comfort. This work conducts simulations and hardware tests. In the development of the driveline and motor control logic, Adaptive Modeling Environment for Simulation analytical software is applied to create the driveline system model. To model structural vibrations, HyperMesh is used, and LS DYNA is applied to simulate free vibration and forced vibration. The analytical results for free vibration are compared with empirical data. The analytical results for driveline dynamics are applied as input for the finite element model to analyze forced vibration. Vibrations from the electric driveline move through the motor mount and frame to the driver’s seat track. The simulation results demonstrate this control logic strategy applied to an electric bus motor controller effectively reduces fluctuation in driveline torque during acceleration by up to 84.19% and during gear shifting by up to 44.96%. The

  20. Vibrating fuel grapple. [LMFBR

    Science.gov (United States)

    Chertock, A.J.; Fox, J.N.; Weissinger, R.B.

    A reactor refueling method is described which utilizes a vibrating fuel grapple for removing spent fuel assemblies from a reactor core. It incorporates a pneumatic vibrator in the grapple head which allows additional withdrawal capability without exceeding the allowable axial force limit. The only moving part in the vibrator is a steel ball, pneumatically driven by a gas, such as argon, around a track, with centrifugal force created by the ball being transmitted through the grapple to the assembly handling socket.

  1. Application study of complex control algorithm for regenerative furnace temperature

    Institute of Scientific and Technical Information of China (English)

    Lusheng GE

    2004-01-01

    Altemative switch combustion mode of air and gas is adopted on the two sides of the regenerative furnace, its temperature is in uncontrolled state in the switching process and the switch period is generally 3 ~ 5 min. Thus, the conventional bi-cross limited combustion control method is no longer applicable to the object. This paper makes use of neutral network algorithm to adjust the static operating point. On this basis, fuzzy control strategy is used for the furnace temperature control. The actual application result shows that the control strategy is effective to solve the problem of the combustion control for regenerative furnace.

  2. Temperature Distribution and Heat Saturating Time of Regenerative Heat Transfer

    Institute of Scientific and Technical Information of China (English)

    Li JIA; Ying MAO; Lixin YANG

    2006-01-01

    In this paper, heat transfer of the ceramic honeycomb regenerator was numerically simulated based on the computational fluid dynamics numerical analysis software CFX5. The longitudinal temperature distribution of regenerator and gas were obtained. The variation of temperature with time was discussed. In addition, the effects of some parameters such as switching time, gas temperature at the inlet of regenerator, height of regenerator and specific heat of the regenerative materials on heat saturating time were discussed. It provided primarily theoretic basis for further study of regenerative heat transfer mechanism.

  3. Regenerative endodontics and tissue engineering: what the future holds?

    Science.gov (United States)

    Goodis, Harold E; Kinaia, Bassam Michael; Kinaia, Atheel M; Chogle, Sami M A

    2012-07-01

    The work performed by researchers in regenerative endodontics and tissue engineering over the last decades has been superb; however, many questions remain to be answered. The basic biologic mechanisms must be elucidated that will allow the development of dental pulp and dentin in situ. Stress must be placed on the many questions that will lead to the design of effective, safe treatment options and therapies. This article discusses those questions, the answers to which may become the future of regenerative endodontics. The future remains bright, but proper support and patience are required.

  4. Regenerative polymeric bus architecture for board-level optical interconnects.

    Science.gov (United States)

    Bamiedakis, N; Hashim, A; Penty, R V; White, I H

    2012-05-21

    A scalable multi-channel optical regenerative bus architecture based on the use of polymer waveguides is presented for the first time. The architecture offers high-speed interconnection between electrical cards allowing regenerative bus extension with multiple segments and therefore connection of an arbitrary number of cards onto the bus. In a proof-of-principle demonstration, a 4-channel 3-card polymeric bus module is designed and fabricated on standard FR4 substrates. Low insertion losses (≤ -15 dB) and low crosstalk values (bus modules using a prototype 3R regenerator.

  5. Nodular regenerative hyperplasia rarely leads to liver transplantation : A 20-year cohort study in all Dutch liver transplant units

    NARCIS (Netherlands)

    Meijer, Berrie; Simsek, Melek; Blokzijl, Hans; de Man, Robert A.; Coenraad, Minneke J.; Dijkstra, Gerard; van Nieuwkerk, Carin M. J.; Mulder, Chris J. J.; de Boer, Nanne K. H.

    2017-01-01

    Background: Nodular regenerative hyperplasia is an uncommon liver condition associated with several autoimmune disorders and drugs. The clinical symptoms of nodular regenerative hyperplasia vary from asymptomatic to severe complications of portal hypertension (nodular regenerative hyperplasia-syndro

  6. Vibrations and stability of complex beam systems

    CERN Document Server

    Stojanović, Vladimir

    2015-01-01

     This book reports on solved problems concerning vibrations and stability of complex beam systems. The complexity of a system is considered from two points of view: the complexity originating from the nature of the structure, in the case of two or more elastically connected beams; and the complexity derived from the dynamic behavior of the system, in the case of a damaged single beam, resulting from the harm done to its simple structure. Furthermore, the book describes the analytical derivation of equations of two or more elastically connected beams, using four different theories (Euler, Rayleigh, Timoshenko and Reddy-Bickford). It also reports on a new, improved p-version of the finite element method for geometrically nonlinear vibrations. The new method provides more accurate approximations of solutions, while also allowing us to analyze geometrically nonlinear vibrations. The book describes the appearance of longitudinal vibrations of damaged clamped-clamped beams as a result of discontinuity (damage). It...

  7. Mechanical Vibrations of Thermally Actuated Silicon Membranes

    Directory of Open Access Journals (Sweden)

    Lynn Fuller

    2012-03-01

    Full Text Available A thermally-actuated micro-electro-mechanical (MEMS device based on a vibrating silicon membrane has been proposed as a viscosity sensor by the authors. In this paper we analyze the vibration mode of the sensor as it vibrates freely at its natural frequency. Analytical examination is compared to finite element analysis, electrical measurements and the results obtained through real-time dynamic optical surface profilometry. The vertical movement of the membrane due to the applied heat is characterized statically and dynamically. The natural vibration mode is determined to be the (1,1 mode and good correlation is found between the analytical predictions, the simulation analysis, the observed mechanical displacement and the electrical measurements.

  8. Long-range vibration sensor based on correlation analysis of optical frequency-domain reflectometry signals.

    Science.gov (United States)

    Ding, Zhenyang; Yao, X Steve; Liu, Tiegen; Du, Yang; Liu, Kun; Han, Qun; Meng, Zhuo; Chen, Hongxin

    2012-12-17

    We present a novel method to achieve a space-resolved long- range vibration detection system based on the correlation analysis of the optical frequency-domain reflectometry (OFDR) signals. By performing two separate measurements of the vibrated and non-vibrated states on a test fiber, the vibration frequency and position of a vibration event can be obtained by analyzing the cross-correlation between beat signals of the vibrated and non-vibrated states in a spatial domain, where the beat signals are generated from interferences between local Rayleigh backscattering signals of the test fiber and local light oscillator. Using the proposed technique, we constructed a standard single-mode fiber based vibration sensor that can have a dynamic range of 12 km and a measurable vibration frequency up to 2 kHz with a spatial resolution of 5 m. Moreover, preliminarily investigation results of two vibration events located at different positions along the test fiber are also reported.

  9. Vibrational properties of uracil

    Institute of Scientific and Technical Information of China (English)

    WANG Zhiping; ZHANG Fengshou; ZENG Xianghua; ZHOU Hongyu; GU Bin; CHENG Wei

    2006-01-01

    A semiempirical molecular dynamics model is developed to study the vibrational frequencies of uracil at very low kinetic temperature by using the Fourier transform of velocity autocorrelation function of trajectories of molecular dynamics simulations. The finite difference harmonic method is used to assign the vibrational frequency of each mode. The calculated frequencies are found to be in good agreement with experimental measurements. Moreover, we make up for the lost vibrational modes in experiments self-consistently. A total of 30 vibrational modes and their corresponding frequencies are reported.

  10. Effects of vibration measurement error on remote sensing image restoration

    Science.gov (United States)

    Sun, Xuan; Wei, Zhang; Zhi, Xiyang

    2016-10-01

    Satellite vibrations would lead to image motion blur. Since the vibration isolators cannot fully suppress the influence of vibrations, image restoration methods are usually adopted, and the vibration characteristics of imaging system are usually required as algorithm inputs for better restoration results, making the vibration measurement error strongly connected to the final outcome. If the measurement error surpass a certain range, the restoration may not be implemented successfully. Therefore it is important to test the applicable scope of restoration algorithms and control the vibrations within the range, on the other hand, if the algorithm is robust, then the requirements for both vibration isolator and vibration detector can be lowered and thus less financial cost is needed. In this paper, vibration-induced degradation is first analyzed, based on which the effects of measurement error on image restoration are further analyzed. The vibration-induced degradation is simulated using high resolution satellite images and then the applicable working condition of typical restoration algorithms are tested with simulation experiments accordingly. The research carried out in this paper provides a valuable reference for future satellite design which plan to implement restoration algorithms.

  11. PREFACE: Vibrations at surfaces Vibrations at surfaces

    Science.gov (United States)

    Rahman, Talat S.

    2011-12-01

    This special issue is dedicated to the phenomenon of vibrations at surfaces—a topic that was indispensible a couple of decades ago, since it was one of the few phenomena capable of revealing the nature of binding at solid surfaces. For clean surfaces, the frequencies of modes with characteristic displacement patterns revealed how surface geometry, as well as the nature of binding between atoms in the surface layers, could be different from that in the bulk solid. Dispersion of the surface phonons provided further measures of interatomic interactions. For chemisorbed molecules on surfaces, frequencies and dispersion of the vibrational modes were also critical for determining adsorption sites. In other words, vibrations at surfaces served as a reliable means of extracting information about surface structure, chemisorption and overlayer formation. Experimental techniques, such as electron energy loss spectroscopy and helium-atom-surface scattering, coupled with infra-red spectroscopy, were continually refined and their resolutions enhanced to capture subtleties in the dynamics of atoms and molecules at surfaces. Theoretical methods, whether based on empirical and semi-empirical interatomic potential or on ab initio electronic structure calculations, helped decipher experimental observations and provide deeper insights into the nature of the bond between atoms and molecules in regions of reduced symmetry, as encountered on solid surfaces. Vibrations at surfaces were thus an integral part of the set of phenomena that characterized surface science. Dedicated workshops and conferences were held to explore the variety of interesting and puzzling features revealed in experimental and theoretical investigations of surface vibrational modes and their dispersion. One such conference, Vibrations at Surfaces, first organized by Harald Ibach in Juelich in 1980, continues to this day. The 13th International Conference on Vibrations at Surfaces was held at the University of

  12. Regenerative thermal purification of waste air using the pebble heater technology; Regenerative Thermische Abluftreinigung mit der Pebble-Heater-Technologie

    Energy Technology Data Exchange (ETDEWEB)

    Stevanovic, D.; Kapp, R. [Applikations- und Technikzentrum fuer Energieverfahrens-, Umwelt- und Stroemungstechnik (ATZ-EVUS), Sulzbach-Rosenberg (Germany); Rueskamp, B. [Lufttechnik Bayeurth, Goldkronach (Germany)

    2001-05-01

    Regenerative thermal post-combustion systems are used for purification of different types of process gases. They are getting increasingly important as legal specifications are getting more rigid. Low-cost solutions are sought for in an attempt to keep the investment cost and operating cost at a low level. [German] Regenerative thermische Nachverbrennungsanlagen werden fuer die Abreinigung verschiedenartiger Prozessgase genutzt. Sie werden immer wichtiger, weil sie die inzwischen sehr strengen gesetzlichen Richtlinien erfuellen. Um Investitions- und Betriebskosten niedrig zu halten, wird auch hier nach kostenguenstigeren Loesungen gesucht. (orig.)

  13. Stem cell bioprinting for applications in regenerative medicine.

    Science.gov (United States)

    Tricomi, Brad J; Dias, Andrew D; Corr, David T

    2016-11-01

    Many regenerative medicine applications seek to harness the biologic power of stem cells in architecturally complex scaffolds or microenvironments. Traditional tissue engineering methods cannot create such intricate structures, nor can they precisely control cellular position or spatial distribution. These limitations have spurred advances in the field of bioprinting, aimed to satisfy these structural and compositional demands. Bioprinting can be defined as the programmed deposition of cells or other biologics, often with accompanying biomaterials. In this concise review, we focus on recent advances in stem cell bioprinting, including performance, utility, and applications in regenerative medicine. More specifically, this review explores the capability of bioprinting to direct stem cell fate, engineer tissue(s), and create functional vascular networks. Furthermore, the unique challenges and concerns related to bioprinting living stem cells, such as viability and maintaining multi- or pluripotency, are discussed. The regenerative capacity of stem cells, when combined with the structural/compositional control afforded by bioprinting, provides a unique and powerful tool to address the complex demands of tissue engineering and regenerative medicine applications.

  14. MicroRNAs in Tissue Engineering and Regenerative Medicine

    NARCIS (Netherlands)

    Krenning, Guido; Harmsen, Martin; Sen, Chandan

    2015-01-01

    The body has a large regenerative capacity to cope with the continuous adverse challenges of high-calorie diets, aging, inflammation, and wear and tear, as well as acute injuries such as myocardial infarction. However, if the amount of sustained damage exceeds the body’s repair capacity, regenerativ

  15. Conversion of a regenerative oxidizer into catalytic unit

    Energy Technology Data Exchange (ETDEWEB)

    Matros, Y.S.; Bunimovich, G.A.; Strots, V.O. [Matros Technologies, Chesterfield, MO (United States)] [and others

    1997-12-31

    Use of a VOC oxidation catalyst in the existing regenerative thermal oxidizers may greatly reduce fuel consumption and improve the oxidizer performance. This was demonstrated in a commercial 25,000 SCFM unit installed at a printing facility. The paper discusses the principles of the oxidizer retrofit design and test results obtained at various conditions of operation.

  16. Adipose-derived regenerative cells in patients with ischemic cardiomyopathy

    DEFF Research Database (Denmark)

    Perin, Emerson C; Sanz-Ruiz, Ricardo; Sánchez, Pedro L

    2014-01-01

    AIMS: Adipose-derived regenerative cells (ADRCs) can be isolated from liposuction aspirates and prepared as fresh cells for immediate administration in cell therapy. We performed the first randomized, placebo-controlled, double-blind trial to examine the safety and feasibility of the transendocar...

  17. Flash-lamp-pumped picosecond Nd:YAG regenerative amplifier

    Institute of Scientific and Technical Information of China (English)

    Bingyuan Zhang; Gang Li; Meng Chen; Guoju Wang; Yonggang Wang; Xiaoyu Ma

    2005-01-01

    @@ A flash-lamp-pumped Nd:YAG regenerative amplifier has been developed at 1.06 μm, seeded with 10-ps pulses from a diode-end-pumped and mode-locked Nd:YAG oscillator with homemade semiconductor saturable absorber mirror(SESAM).

  18. Regenerative memory in time-delayed neuromorphic photonic systems

    CERN Document Server

    Romeira, B; Figueiredo, José M L; Barland, S; Javaloyes, J

    2015-01-01

    We investigate a regenerative memory based upon a time-delayed neuromorphic photonic oscillator and discuss the link with temporal localized structures. Our experimental implementation is based upon a optoelectronic system composed of a nanoscale nonlinear resonant tunneling diode coupled to a laser that we link to the paradigm of neuronal activity, the FitzHugh-Nagumo model with delayed feedback.

  19. Emdogain in regenerative periodontal therapy. A review of the literature.

    NARCIS (Netherlands)

    Sculean, A.; Windisch, P.; Dori, F.; Keglevich, T.; Molnar, B.; Gera, I.

    2007-01-01

    The goal of regenerative periodontal therapy is the reconstitution of the lost periodontal structures (i.e. the new formation of root cementum, periodontal ligament and alveolar bone). Results from basic research have pointed to the important role of the enamel matrix protein derivative (EMD) in the

  20. Formation of human cementum following different modalities of regenerative therapy.

    NARCIS (Netherlands)

    Sculean, A.; Stavropoulos, A.; Berakdar, M.; Windisch, P.; Karring, T.; Brecx, M.

    2005-01-01

    The aim of the present study was to compare newly formed cementum following different types of regenerative therapy in humans. Eighteen patients, each displaying one advanced intrabony defect around teeth scheduled for extraction, were included in this study. The defects were treated with either gui

  1. Turning Regenerative Medicine Breakthrough Ideas and Innovations into Commercial Products.

    Science.gov (United States)

    Bayon, Yves; Vertès, Alain A; Ronfard, Vincent; Culme-Seymour, Emily; Mason, Chris; Stroemer, Paul; Najimi, Mustapha; Sokal, Etienne; Wilson, Clayton; Barone, Joe; Aras, Rahul; Chiesi, Andrea

    2015-12-01

    The TERMIS-Europe (EU) Industry committee intended to address the two main critical issues in the clinical/commercial translation of Advanced Therapeutic Medicine Products (ATMP): (1) entrepreneurial exploitation of breakthrough ideas and innovations, and (2) regulatory market approval. Since January 2012, more than 12,000 publications related to regenerative medicine and tissue engineering have been accepted for publications, reflecting the intense academic research activity in this field. The TERMIS-EU 2014 Industry Symposium provided a reflection on the management of innovation and technological breakthroughs in biotechnology first proposed to contextualize the key development milestones and constraints of allocation of financial resources, in the development life-cycle of radical innovation projects. This was illustrated with the biofuels story, sharing similarities with regenerative medicine. The transition was then ensured by an overview of the key identified challenges facing the commercialization of cell therapy products as ATMP examples. Real cases and testimonies were then provided by a palette of medical technologies and regenerative medicine companies from their commercial development of cell and gene therapy products. Although the commercial development of ATMP is still at the proof-of-concept stage due to technology risks, changing policies, changing markets, and management changes, the sector is highly dynamic with a number of explored therapeutic approaches, developed by using a large diversity of business models, both proposed by the experience, pitfalls, and successes of regenerative medicine pioneers, and adapted to the constraint resource allocation and environment in radical innovation projects.

  2. Erich Regener and the maximum in ionisation of the atmosphere

    CERN Document Server

    Carlson, P

    2014-01-01

    In the 1930s the German physicist Erich Regener (1881-1955) did important work on the measurement of the rate of production of ionisation deep under-water and in the atmosphere. He discovered, along with one of his students, Georg Pfotzer, the altitude at which the production of ionisation in the atmosphere reaches a maximum, often, but misleadingly, called the Pfotzer maximum. Regener was one of the first to estimate the energy density of cosmic rays, an estimate that was used by Baade and Zwicky to bolster their postulate that supernovae might be their source. Yet Regener's name is less recognised by present-day cosmic ray physicists than it should be largely because in 1937 he was forced to take early retirement by the National Socialists as his wife had Jewish ancestors. In this paper we briefly review his work on cosmic rays and recommend an alternative naming of the ionisation maximum. The influence that Regener had on the field through his son, his son-in-law, his grandsons and his students and through...

  3. Translational Approaches in Tissue Engineering and Regenerative Medicine

    CERN Document Server

    Mao, Jeremy J

    2007-01-01

    This landmark book identifies the current and forthcoming roadblocks to scientific research and technological development in stem cell research, tissue engineering, wound healing, and in-vivo animal models. The book is the first to focus on the translational aspect of tissue engineering and regenerative medicine and bridges the gap between laboratory discovery and clinical applications.

  4. Regenerative Snubber For GTO-Commutated SCR Inverter

    Science.gov (United States)

    Rippel, Wally E.; Edwards, Dean B.

    1992-01-01

    Proposed regenerative snubbing circuit substituted for dissipative snubbing circuit in inverter based on silicon controlled rectifiers (SCR's) commutated by gate-turn-off thyristor (GTO). Intended to reduce loss of power that occurs in dissipative snubber. Principal criteria in design: low cost, simplicity, and reliability.

  5. Mechanical cues in orofacial tissue engineering and regenerative medicine

    NARCIS (Netherlands)

    Brouwer, K.M.; Lundvig, D.M.S.; Middelkoop, E.; Wagener, F.A.D.T.G.; Hoff, J.W. Von den

    2015-01-01

    Cleft lip and palate patients suffer from functional, aesthetical, and psychosocial problems due to suboptimal regeneration of skin, mucosa, and skeletal muscle after restorative cleft surgery. The field of tissue engineering and regenerative medicine (TE/RM) aims to restore the normal physiology of

  6. Vibrational Schroedinger Cats

    Science.gov (United States)

    Kis, Z.; Janszky, J.; Vinogradov, An. V.; Kobayashi, T.

    1996-01-01

    The optical Schroedinger cat states are simple realizations of quantum states having nonclassical features. It is shown that vibrational analogues of such states can be realized in an experiment of double pulse excitation of vibrionic transitions. To track the evolution of the vibrational wave packet we derive a non-unitary time evolution operator so that calculations are made in a quasi Heisenberg picture.

  7. Vibration Theory, Vol. 3

    DEFF Research Database (Denmark)

    Nielsen, Søren R. K.

    The present textbook has been written based on previous lecture notes for a course on stochastic vibration theory that is being given on the 9th semester at Aalborg University for M. Sc. students in structural engineering. The present 4th edition of this textbook on linear stochastic vibration...

  8. [Vibration on agricultural tractors].

    Science.gov (United States)

    Peretti, Alessandro; Delvecchio, Simone; Bonomini, Francesco; di Bisceglie, Anita Pasqua; Colosio, Claudio

    2013-01-01

    In the article, details related to the diffusion of agricultural tractors in Italy are given and considerations about the effects of vibration on operators, the sources of vibration and suggestions to reduce them are presented. The acceleration values observed in Italy amongst 244 tractors and levels of worker exposure are shown by means of histograms. The relevant data variability is discussed.

  9. Picking up good vibrations

    NARCIS (Netherlands)

    Eijk, A.

    2010-01-01

    The methods that need to be employed to develop the better vibration guidelines to assess the integrity of a reciprocating compressor system are discussed. An R&D project of the European Forum of Reciprocating Compressors (EFRC) has been initiated to develop guidelines for vibrations in reciprocatin

  10. Vibration Theory, Vol. 3

    DEFF Research Database (Denmark)

    Nielsen, Søren R. K.

    The present textbook has been written based on previous lecture notes for a course on stochastic vibration theory that is being given on the 9th semester at Aalborg University for M. Sc. students in structural engineering. The present 2nd edition of this textbook on linear stochastic vibration th...

  11. Mechanical vibration and shock analysis, sinusoidal vibration

    CERN Document Server

    Lalanne, Christian

    2014-01-01

    Everything engineers need to know about mechanical vibration and shock...in one authoritative reference work! This fully updated and revised 3rd edition addresses the entire field of mechanical vibration and shock as one of the most important types of load and stress applied to structures, machines and components in the real world. Examples include everything from the regular and predictable loads applied to turbines, motors or helicopters by the spinning of their constituent parts to the ability of buildings to withstand damage from wind loads or explosions, and the need for cars to m

  12. SPE (tm) regenerative hydrogen/oxygen fuel cells for extraterrestrial surface and microgravity applications

    Science.gov (United States)

    Mcelroy, J. F.

    1990-01-01

    Viewgraphs on SPE regenerative hydrogen/oxygen fuel cells for extraterrestrial surface and microgravity applications are presented. Topics covered include: hydrogen-oxygen regenerative fuel cell energy storage system; electrochemical cell reactions; SPE cell voltage stability; passive water removal SPE fuel cell; fuel cell performance; SPE water electrolyzers; hydrophobic oxygen phase separator; hydrophilic/electrochemical hydrogen phase separator; and unitized regenerative fuel cell.

  13. Vibration control in accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Montag, C.

    2011-01-01

    In the vast majority of accelerator applications, ground vibration amplitudes are well below tolerable magnet jitter amplitudes. In these cases, it is necessary and sufficient to design a rigid magnet support structure that does not amplify ground vibration. Since accelerator beam lines are typically installed at an elevation of 1-2m above ground level, special care has to be taken in order to avoid designing a support structure that acts like an inverted pendulum with a low resonance frequency, resulting in untolerable lateral vibration amplitudes of the accelerator components when excited by either ambient ground motion or vibration sources within the accelerator itself, such as cooling water pumps or helium flow in superconducting magnets. In cases where ground motion amplitudes already exceed the required jiter tolerances, for instance in future linear colliders, passive vibration damping or active stabilization may be considered.

  14. Vibrational Spectroscopy of Biomembranes

    Science.gov (United States)

    Schultz, Zachary D.; Levin, Ira W.

    2011-07-01

    Vibrational spectroscopy, commonly associated with IR absorption and Raman scattering, has provided a powerful approach for investigating interactions between biomolecules that make up cellular membranes. Because the IR and Raman signals arise from the intrinsic properties of these molecules, vibrational spectroscopy probes the delicate interactions that regulate biomembranes with minimal perturbation. Numerous innovative measurements, including nonlinear optical processes and confined bilayer assemblies, have provided new insights into membrane behavior. In this review, we highlight the use of vibrational spectroscopy to study lipid-lipid interactions. We also examine recent work in which vibrational measurements have been used to investigate the incorporation of peptides and proteins into lipid bilayers, and we discuss the interactions of small molecules and drugs with membrane structures. Emerging techniques and measurements on intact cellular membranes provide a prospective on the future of vibrational spectroscopic studies of biomembranes.

  15. The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain

    Directory of Open Access Journals (Sweden)

    Kizil Caghan

    2012-07-01

    Full Text Available Abstract Background Unlike mammals, zebrafish exhibits extensive neural regeneration after injury in adult stages of its lifetime due to the neurogenic activity of the radial glial cells. However, the genes involved in the regenerative neurogenesis response of the zebrafish brain are largely unknown. Thus, understanding the underlying principles of this regeneration capacity of the zebrafish brain is an interesting research realm that may offer vast clinical ramifications. Results In this paper, we characterized the expression pattern of cxcr5 and analyzed the function of this gene during adult neurogenesis and regeneration of the zebrafish telencephalon. We found that cxcr5 was upregulated transiently in the RGCs and neurons, and the expression in the immune cells such as leukocytes was negligible during both adult neurogenesis and regeneration. We observed that the transgenic misexpression of cxcr5 in the ventricular cells using dominant negative and full-length variants of the gene resulted in altered proliferation and neurogenesis response of the RGCs. When we knocked down cxcr5 using antisense morpholinos and cerebroventricular microinjection, we observed outcomes similar to the overexpression of the dominant negative cxcr5 variant. Conclusions Thus, based on our results, we propose that cxcr5 imposes a proliferative permissiveness to the radial glial cells and is required for differentiation of the RGCs to neurons, highlighting novel roles of cxcr5 in the nervous system of vertebrates. We therefore suggest that cxcr5 is an important cue for ventricular cell proliferation and regenerative neurogenesis in the adult zebrafish telencephalon. Further studies on the role of cxcr5 in mediating neuronal replenishment have the potential to produce clinical ramifications in efforts for regenerative therapeutic applications for human neurological disorders or acute injuries.

  16. THEORETICAL MODEL OF VIBRATING OBJECT TRANSMITTING NOISE TOWARDS EXTERNAL SOUND

    Institute of Scientific and Technical Information of China (English)

    姚志远

    2002-01-01

    On the basic theory of modal method, the coupling relation between the vibration of objects and external sound was analyzed, the theoretical model solving the vibration and noise was provided, the corresponding calculation formula was given. The calculating results show out that this calculation formula is correct.

  17. Vibration Analysis of Digital Radiography System for Large Container Inspection

    Institute of Scientific and Technical Information of China (English)

    黄松岭; 李路明; 周立业; 向新程; 安继刚

    2003-01-01

    The cantilever vibration characteristics of a digital radiography system were analyzed to predict the effect of vibration on the performance of a mobile container inspection system. The static deformation,vibration mode and natural frequency of the cantilever of the digital radiography system were calculated with the ALGOR Finite Element System to verify the strength and rigidity of the cantilever. The maximum amplitude of the cantilever vibration occurs as it starts accelerating. The predictions show good agreement with test results, indicating that the finite element model of the cantilever structure accurately models the mechanical characteristics.

  18. Explicit Correlated Exciton-Vibrational Dynamics of the FMO Complex

    CERN Document Server

    Schulze, Jan

    2015-01-01

    The coupled exciton-vibrational dynamics of a 3-site FMO model is investigated using the numerically exact multilayer multiconfiguration time-dependent Hartree approach. Thereby the vibrational mode specific coupling to local electronic transitions is adapted from a discretized experimental spectral density. The solution of the resulting time-dependent Schr\\"odinger equation including three electronic and 450 vibrational degrees of freedom is analyzed in terms of excitonic populations and coherences. Emphasis is put onto the role of specific ranges of vibrational frequencies. It is observed that modes between 160 and 300 cm$^{-1}$ are responsible for the subpicosecond population and coherence decay.

  19. Analysis of torque transmitting behavior and wheel slip prevention control during regenerative braking for high speed EMU trains

    Science.gov (United States)

    Xu, Kun; Xu, Guo-Qing; Zheng, Chun-Hua

    2016-04-01

    The wheel-rail adhesion control for regenerative braking systems of high speed electric multiple unit trains is crucial to maintaining the stability, improving the adhesion utilization, and achieving deep energy recovery. There remain technical challenges mainly because of the nonlinear, uncertain, and varying features of wheel-rail contact conditions. This research analyzes the torque transmitting behavior during regenerative braking, and proposes a novel methodology to detect the wheel-rail adhesion stability. Then, applications to the wheel slip prevention during braking are investigated, and the optimal slip ratio control scheme is proposed, which is based on a novel optimal reference generation of the slip ratio and a robust sliding mode control. The proposed methodology achieves the optimal braking performance without the wheel-rail contact information. Numerical simulation results for uncertain slippery rails verify the effectiveness of the proposed methodology.

  20. The multilayer and wide-deck vibrating screen based on the innovative long-span vibration exciter

    Science.gov (United States)

    Zeng, Ming; Xu, Zonglin; Zhang, Jinnan; Zhang, Minghong

    2017-09-01

    The multilayer and wide-deck innovative single plasmid vibration screen is applicable to the petroleum drilling and the other relevant industries. The structural features and advantages of the components are illustrated, and the innovative long-span vibration exciter together with the steel rope saddle block flexible coupling is emphatically analyzed. Two engineering examples are provided to make the explanation.

  1. Dynamic Vibration Absorber with Negative Stiffness for Rotor System

    Directory of Open Access Journals (Sweden)

    Hongliang Yao

    2016-01-01

    Full Text Available To suppress the vibration of a rotor system, a vibration absorber combining negative stiffness with positive stiffness together is proposed in this paper. Firstly, the negative stiffness producing mechanism using ring type permanent magnets is presented and the characteristics of the negative stiffness are analyzed. Then, the structure of the absorber is proposed; the principles and nonlinear dynamic characteristics of the absorber-rotor system are studied numerically. Finally, experiments are carried out to verify the numerical conclusions. The results show that the proposed vibration absorber is effective to suppress the vibration of the rotor system, the nonlinearity of the negatives stiffness affects the vibration suppression effect little, and the negative stiffness can broaden the effective vibration control frequency range of the absorber.

  2. The Vibration of a Linear Carbon Chain in Carbon Nanotubes

    Directory of Open Access Journals (Sweden)

    Dongqing Ding

    2017-04-01

    Full Text Available An explicit solution for the vibration of a carbon chain inside carbon nanotubes (CNTs was obtained using continuum modeling of the van der Waals (vdW interactions between them. The effect of the initial tensile force and the amplitude of the carbon chain as well as the radii of the CNTs on the vibration frequency were analyzed in detail, respectively. Our analytical results show that the vibration frequency of the carbon chain in a (5,5 CNT could be around two orders of magnitude higher than that of an independent carbon chain without initial tensile force. For a given CNT radius, the vibration frequency nonlinearly increases with increasing amplitude and initial tensile force. The obtained analytical cohesive energy and vibration frequency are reasonable by comparison of present molecular dynamics (MD simulations. These findings will be a great help towards understanding the vibration property of a nanowire in nanotubes, and designing nanoelectromechanical devices.

  3. Experimental vibration level analysis of a Francis turbine

    Science.gov (United States)

    Bucur, D. M.; Dunca, G.; Cǎlinoiu, C.

    2012-11-01

    In this study the vibration level of a Francis turbine is investigated by experimental work in site. Measurements are carried out for different power output values, in order to highlight the influence of the operation regimes on the turbine behavior. The study focuses on the turbine shaft to identify the mechanical vibration sources and on the draft tube in order to identify the hydraulic vibration sources. Analyzing the vibration results, recommendations regarding the operation of the turbine, at partial load close to minimum values, in the middle of the operating domain or close to maximum values of electric power, can be made in order to keep relatively low levels of vibration. Finally, conclusions are drawn in order to present the real sources of the vibrations.

  4. Inverted Pendulum-type Personal Mobility Considering Human Vibration Sensitivity

    Directory of Open Access Journals (Sweden)

    Misaki Masuda

    2014-01-01

    Full Text Available An inverted pendulum-type PM (personal mobility has been attracting attention as a low-carbon vehicle. For many people who like to use the PM, ride comfort is important. However, ride comfort of PM has not been focused on in previous studies. The vibration is one of causes that make riders feel uncomfortable. The PM is unstable system and horizontal vibration may be caused by a stabilizing control. Additionally, vertical vibration may also be caused by road disturbances. This study analyzes the vibration of the rider’s head in these two directions when the PM runs on a road with disturbances in numerical simulations, and evaluates ride comfort with the frequency characteristics of the vibration. To consider human vibration sensitivity, the frequency weighting proposed in ISO 2631-1 is used as an evaluation standard. The improvement methods are proposed from both software and hardware, and it is confirmed that the proposed method can improve ride comfort.

  5. THz-SAR Vibrating Target Imaging via the Bayesian Method

    Directory of Open Access Journals (Sweden)

    Bin Deng

    2017-01-01

    Full Text Available Target vibration bears important information for target recognition, and terahertz, due to significant micro-Doppler effects, has strong advantages for remotely sensing vibrations. In this paper, the imaging characteristics of vibrating targets with THz-SAR are at first analyzed. An improved algorithm based on an excellent Bayesian approach, that is, the expansion-compression variance-component (ExCoV method, has been proposed for reconstructing scattering coefficients of vibrating targets, which provides more robust and efficient initialization and overcomes the deficiencies of sidelobes as well as artifacts arising from the traditional correlation method. A real vibration measurement experiment of idle cars was performed to validate the range model. Simulated SAR data of vibrating targets and a tank model in a real background in 220 GHz show good performance at low SNR. Rapidly evolving high-power terahertz devices will offer viable THz-SAR application at a distance of several kilometers.

  6. VIBRATION ANALYSIS OF TURBINE BASED ON FLUID-STRUCTURE COUPLING

    Institute of Scientific and Technical Information of China (English)

    LIU Demin; LIU Xiaobing

    2008-01-01

    The vibration of a Francis turbine is analyzed with the additional quality matrix method based on fluid-structure coupling (FSC). Firstly, the vibration frequency and mode of blade and runner in air and water are calculated. Secondly, the influences to runner frequency domain by large flow, small flow and design flow working conditions are compared. Finally the influences to runner modes by centrifugal forces under three rotating speeds of 400 r/min, 500 r/min and 600 r/min are compared. The centrifugal force and small flow working condition have greatly influence on the vibration of small runner. With the increase of centrifugal force, the vibration frequency of the runner is sharply increased. Some order frequencies are even close to the runner natural frequency in the air. Because the low frequency vibration will severely damage the stability of the turbine, low frequency vibration of units should be avoided as soon as possible.

  7. Analysis of torsional vibration in an electromechanical transmission system

    Directory of Open Access Journals (Sweden)

    Kai Chen

    2016-06-01

    Full Text Available Aiming at the torsional vibration in the electromechanical transmission system, this article introduces the active vibration method and analyzes the vibration characteristics on the condition of the external excitation, and then, the condition of the permanent magnetic synchronous motor parameter is obtained. In the braking energy recovery working condition, the permanent magnetic synchronous motor is operated in generator mode and is subjected to power control, this cause it to produce negative effect of damping. Negative effect of damping leads to the increasing torsional vibration. Then, the improved power control strategy is introduced to reduce the vibration. Computer simulations are used to demonstrate the active vibration method and the effectiveness of the proposed control strategy, which provides reference for the design of electromechanical systems in the hybrid electrical vehicles.

  8. Ideal thermodynamic processes of oscillatory-flow regenerative engines will go to ideal stirling cycle?

    Science.gov (United States)

    Luo, Ercang

    2012-06-01

    This paper analyzes the thermodynamic cycle of oscillating-flow regenerative machines. Unlike the classical analysis of thermodynamic textbooks, the assumptions for pistons' movement limitations are not needed and only ideal flowing and heat transfer should be maintained in our present analysis. Under such simple assumptions, the meso-scale thermodynamic cycles of each gas parcel in typical locations of a regenerator are analyzed. It is observed that the gas parcels in the regenerator undergo Lorentz cycle in different temperature levels, whereas the locus of all gas parcels inside the regenerator is the Ericson-like thermodynamic cycle. Based on this new finding, the author argued that ideal oscillating-flow machines without heat transfer and flowing losses is not the Stirling cycle. However, this new thermodynamic cycle can still achieve the same efficiency of the Carnot heat engine and can be considered a new reversible thermodynamic cycle under two constant-temperature heat sinks.

  9. Thermodynamic analysis for a regenerative gas turbine cycle in coking process

    Directory of Open Access Journals (Sweden)

    Zelong Zhang, Lingen Chen, Yanlin Ge, Fengrui Sun

    2014-01-01

    Full Text Available A regenerative gas turbine cycle driven by residual coke oven gas is proposed in this paper. The thermal efficiency and the work output (per ton of coke of the system are analyzed based on thermodynamics and the theory of gas turbine cycle. The influences of the gas release rate, the residual gas rate and the effectiveness of regenerator on the performance of the cycle are analyzed by using numerical examples. It is found that the work output increases with the increase of the residual gas rate while decreases with the increase of the gas release rate. The cycle with regenerator can reach higher thermal efficiency and bigger work output, which means that the coke oven gas is used more effectively. Moreover, there exist two optimal pressure ratios of compressor which lead the maximum thermal efficiency and the maximum specific work, respectively.

  10. Barrier Vibration Isolation to Work-Place Vibration and Its Influence on Uneven Subsidence of Pillar Foundation

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Aiming at practice, the wave propagation in soil has been comprehensively studied on the basis of FEM analyzing model being established. An investigation has also been performed on how to solve the problems of simulating transient vibration in actual foundation with FEM, and the result of calculating to the real transient vibration of actual foundation with FEM software ANSYS agrees with that of measuring. The vibration variation in the ground and the uneven subsidence of the factory houses' pillars, with and without barrier vibration isolation, are calculated by employing FEM. The results show that proper barrier isolation can diminish the ground vibration displacement but likely to magnify the dynamic stress and vibration frequency within a certain region, which would aggravate the uneven subsidence of the factory house pillars.

  11. Coherent vibrational dynamics

    CERN Document Server

    Lanzani, Guglielmo; De Silvestri, Sandro

    2007-01-01

    Vibrational spectroscopy is a powerful investigation tool for a wide class of materials covering diverse areas in physics, chemistry and biology. The continuous development in the laser field regarding ultrashort pulse generation has led to the possibility of producing light pulses that can follow vibrational motion coupled to the electronic transitions in molecules and solids in real time. Aimed at researchers and graduate students using vibrational spectroscopy, this book provides both introductory chapters as well as more advanced contents reporting on recent progress. It also provides a good starting point for scientists seeking a sound introduction to ultrafast optics and spectroscopic techniques.

  12. Recurrence plot analysis of nonlinear vibrational dynamics in H sub 3 sup + molecule

    CERN Document Server

    Babinec, P

    2003-01-01

    An ab initio classical trajectories obtained from the simulation of vibrational mode dynamics of H sub 3 sup + molecule were analyzed by Fourier transform and recurrence plot analysis. As has been found, at a particular value of energy supplied to vibrational modes (slightly above the zero point energy) the character of vibrational motion changes from regular to chaotic.

  13. Insurance systems and reimbursement concerning research and development of regenerative medicine in Japan.

    Science.gov (United States)

    Okada, Kiyoshi; Miyata, Toshio; Sawa, Yoshiki

    2017-03-01

    In Japan, the Act on the Safety of Regenerative Medicine and the Pharmaceuticals, Medical Devices and Other Therapeutic Products Act were enacted in November 2014, creating a new framework for clinical research and products related to regenerative medicine. Together with these regulatory frameworks, new insurance procedures were created for handling regenerative medicine in Japan. For developing regenerative medicine in Japan, understanding medical insurance greatly influences funding and venture success, particularly in the stages between clinical research and market launch. The study aimed to identify the issues and examples surrounding Japan's present medical insurance system, especially for regenerative medicine. We believe that building stronger insurance systems for regenerative medicine is essential for internationally aligning and harmonizing the progress of regenerative medicine.

  14. Vibration Accounts for the Lost Energy Abstract

    Institute of Scientific and Technical Information of China (English)

    王成龙; 王潇明; 王青

    2010-01-01

    @@ Many studies on how to improve the velocity of ball are ongoing. Here we attempt to analyze and model the vibration of the bat, which plays a vital role in determining the exit speed of the ball and confirming the location of the sweet spot of the bat.

  15. Influence of maximum decking charge on intensity of blasting vibration

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Based on the character of short-time non-stationary random signal, the relationship between the maximum decking charge and energy distribution of blasting vibration signals was investigated by means of the wavelet packet method. Firstly, the characteristics of wavelet transform and wavelet packet analysis were described. Secondly, the blasting vibration signals were analyzed by wavelet packet based on software MATLAB, and the change of energy distribution curve at different frequency bands were obtained. Finally, the law of energy distribution of blasting vibration signals changing with the maximum decking charge was analyzed. The results show that with the increase of decking charge, the ratio of the energy of high frequency to total energy decreases, the dominant frequency bands of blasting vibration signals tend towards low frequency and blasting vibration does not depend on the maximum decking charge.

  16. Vibrating wire alignment technique

    CERN Document Server

    Xiao-Long, Wang; lei, Wu; Chun-Hua, Li

    2013-01-01

    Vibrating wire alignment technique is a kind of method which through measuring the spatial distribution of magnetic field to do the alignment and it can achieve very high alignment accuracy. Vibrating wire alignment technique can be applied for magnet fiducialization and accelerator straight section components alignment, it is a necessary supplement for conventional alignment method. This article will systematically expound the international research achievements of vibrating wire alignment technique, including vibrating wire model analysis, system frequency calculation, wire sag calculation and the relation between wire amplitude and magnetic induction intensity. On the basis of model analysis this article will introduce the alignment method which based on magnetic field measurement and the alignment method which based on amplitude and phase measurement. Finally, some basic questions will be discussed and the solutions will be given.

  17. Vibration enhanced quantum transport

    CERN Document Server

    Semião, F L; Milburn, G J

    2009-01-01

    In this paper, we study the role of a collective vibrational motion in the phenomenon of electronic energy transfer (EET) between chromophores with different electronic transition frequencies. Previous experimental work on EET in conjugated polymer samples has suggested that the common structural framework of the macromolecule introduce correlations in the energy gap fluctuations which cause coherent EET. We present a simple model describing the coupling between the chromophores and a common vibrational mode, and find that vibration can indeed lead to an enhancement in the transport of excitations across the quantum network. Furthermore, in our model phase information is partially retained in the transfer process from a donor to an acceptor, as experimentally demonstrated in the conjugated polymer system. Consequently, this mechanism of vibration enhanced quantum transport might find applications in quantum information transfer of qubit states or entanglement.

  18. NIF Ambient Vibration Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Noble, C.R.; Hoehler, M.S., S.C. Sommer

    1999-11-29

    LLNL has an ongoing research and development project that includes developing data acquisition systems with remote wireless communication for monitoring the vibrations of large civil engineering structures. In order to establish the capability of performing remote sensing over an extended period of time, the researchers needed to apply this technology to a real structure. The construction of the National Ignition Facility provided an opportunity to test the data acquisition system on a large structure to monitor whether the facility is remaining within the strict ambient vibration guidelines. This document will briefly discuss the NIF ambient vibration requirements and summarize the vibration measurements performed during the Spring and Summer of 1999. In addition, a brief description of the sensors and the data acquisition systems will be provided in Appendix B.

  19. NIF Ambient Vibration Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Noble, C.R.; Hoehler, M.S., S.C. Sommer

    1999-11-29

    LLNL has an ongoing research and development project that includes developing data acquisition systems with remote wireless communication for monitoring the vibrations of large civil engineering structures. In order to establish the capability of performing remote sensing over an extended period of time, the researchers needed to apply this technology to a real structure. The construction of the National Ignition Facility provided an opportunity to test the data acquisition system on a large structure to monitor whether the facility is remaining within the strict ambient vibration guidelines. This document will briefly discuss the NIF ambient vibration requirements and summarize the vibration measurements performed during the Spring and Summer of 1999. In addition, a brief description of the sensors and the data acquisition systems will be provided in Appendix B.

  20. 2008 Vibrational Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Philip J. Reid

    2009-09-21

    The conference focuses on using vibrational spectroscopy to probe structure and dynamics of molecules in gases, liquids, and interfaces. The goal is to bring together a collection of researchers who share common interests and who will gain from discussing work at the forefront of several connected areas. The intent is to emphasize the insights and understanding that studies of vibrations provide about a variety of systems.

  1. Derivation and application of pluripotent stem cells for regenerative medicine.

    Science.gov (United States)

    Wang, Jiaqiang; Zhou, Qi

    2016-06-01

    Pluripotent stem cells (PSCs) are cells that can differentiate into any type of cells in the body, therefore have valuable promise in regenerative medicine of cell replacement therapies and tissue/organ engineering. PSCs can be derived either from early embryos or directly from somatic cells by epigenetic reprogramming that result in customized cells from patients. Here we summarize the methods of deriving PSCs, the various types of PSCs generated with different status, and their versatile applications in both clinical and embryonic development studies. We also discuss an intriguing potential application of PSCs in constructing tissues/organs in large animals by interspecies chimerism. All these emerging findings are likely to contribute to the breakthroughs in biological research and the prosperous prospects of regenerative medicine.

  2. Regenerative medicine using dental pulp stem cells for liver diseases

    Science.gov (United States)

    Ohkoshi, Shogo; Hara, Hajime; Hirono, Haruka; Watanabe, Kazuhiko; Hasegawa, Katsuhiko

    2017-01-01

    Acute liver failure is a refractory disease and its prognosis, if not treated using liver transplantation, is extremely poor. It is a good candidate for regenerative medicine, where stem cell-based therapies play a central role. Mesenchymal stem cells (MSCs) are known to differentiate into multiple cell lineages including hepatocytes. Autologous cell transplant without any foreign gene induction is feasible using MSCs, thereby avoiding possible risks of tumorigenesis and immune rejection. Dental pulp also contains an MSC population that differentiates into hepatocytes. A point worthy of special mention is that dental pulp can be obtained from deciduous teeth during childhood and can be subsequently harvested when necessary after deposition in a tooth bank. MSCs have not only a regenerative capacity but also act in an anti-inflammatory manner via paracrine mechanisms. Promising efficacies and difficulties with the use of MSC derived from teeth are summarized in this review. PMID:28217369

  3. Differentiation of pluripotent stem cells for regenerative medicine.

    Science.gov (United States)

    Li, Ke; Kong, Yan; Zhang, Mingliang; Xie, Fei; Liu, Peng; Xu, Shaohua

    2016-02-26

    A long-standing goal in regenerative medicine is to obtain scalable functional cells on demand to replenish cells lost in various conditions, including relevant diseases, injuries, and aging. As an unlimited cell source, pluripotent stem cells (PSCs) are invaluable for regenerative medicine, because they have the potential to give rise to any cell type in an organism. For therapeutic purposes, it is important to develop specific approach to directing PSC differentiation towards desired cell types efficiently. Through directed differentiation, PSCs could give rise to scalable, clinically relevant cells for in vivo transplantation, as well as for studying diseases in vitro and discovering drugs to treat them. Over the past few years, significant progress has been made in directing differentiation of PSCs into a variety of cell types. In this review, we discuss recent progress in directed differentiation of PSCs, clinical translation of PSC-based cell replacement therapies, and remaining challenges.

  4. Stem cells: a promising source for vascular regenerative medicine.

    Science.gov (United States)

    Rammal, Hassan; Harmouch, Chaza; Lataillade, Jean-Jacques; Laurent-Maquin, Dominique; Labrude, Pierre; Menu, Patrick; Kerdjoudj, Halima

    2014-12-15

    The rising and diversity of many human vascular diseases pose urgent needs for the development of novel therapeutics. Stem cell therapy represents a challenge in the medicine of the twenty-first century, an area where tissue engineering and regenerative medicine gather to provide promising treatments for a wide variety of diseases. Indeed, with their extensive regeneration potential and functional multilineage differentiation capacity, stem cells are now highlighted as promising cell sources for regenerative medicine. Their multilineage differentiation involves environmental factors such as biochemical, extracellular matrix coating, oxygen tension, and mechanical forces. In this review, we will focus on human stem cell sources and their applications in vascular regeneration. We will also discuss the different strategies used for their differentiation into both mature and functional smooth muscle and endothelial cells.

  5. Study of the minimum refrigeration temperature of regenerative cryocoolers

    Science.gov (United States)

    Chen, Guangming; Chen, Guobang; Yu, Jianping

    Based on the principles of thermodynamics, the relation between the isentropic expansion coefficient μs and the isobaric specific heat Cp has been found. The values of μs at different temperatures and pressures are calculated. From theoretical and experimental values of Cp of helium in the supercritical area, the minimum refrigeration temperature which may be reached by traditional regenerative cryocoolers is theoretically demonstrated. It is pointed out that this boundary is just the lambda line of helium. In order to obtain temperatures lower than the lambda line, a new type of regenerative cryocooler which can work in the helium II region is proposed. The working principle, schematic diagram and theoretical refrigeration temperature of this new cryocooler are discussed.

  6. The Conduction of Heat through Cryogenic Regenerative Heat Exchangers

    Science.gov (United States)

    Superczynski, W. F.; Green, G. F.

    2006-04-01

    The need for improved regenerative cryocooler efficiency may require the replacement of conventional matrices with ducts. The ducts can not be continuous in the direction of temperature gradient when using conventional materials to prevent unacceptable conduction losses. However, this discontinuity creates a complex geometry to model and determine conduction losses. Chesapeake Cryogenics, Inc. has designed, fabricated and tested an apparatus for measuring the heat conduction through regenerative heat exchangers implementing different matrices. Data is presented for stainless steel photo etched disk, phophorus-bronze embossed ribbon coils and screens made of both stainless steel and phosphorus-bronze. The heat conduction was measured with the regenerators evacuated and pressurized with helium gas. In this test apparatus, helium gas presence increased the heat leak significantly. A description of the test apparatus, instrumentation, experimental methods and data analysis are presented.

  7. Spacecraft Radiator Freeze Protection Using a Regenerative Heat Exchanger

    Science.gov (United States)

    Ungar, Eugene K.; Schunk, Richard G.

    2011-01-01

    An active thermal control system architecture has been modified to include a regenerative heat exchanger (regenerator) inboard of the radiator. Rather than using a radiator bypass valve a regenerative heat exchanger is placed inboard of the radiators. A regenerator cold side bypass valve is used to set the return temperature. During operation, the regenerator bypass flow is varied, mixing cold radiator return fluid and warm regenerator outlet fluid to maintain the system setpoint. At the lowest heat load for stable operation, the bypass flow is closed off, sending all of the flow through the regenerator. This lowers the radiator inlet temperature well below the system set-point while maintaining full flow through the radiators. By using a regenerator bypass flow control to maintain system setpoint, the required minimum heat load to avoid radiator freezing can be reduced by more than half compared to a radiator bypass system.

  8. [Ethical, legal and social issues on regenerative medicine].

    Science.gov (United States)

    Tsukata, Yukiyoshi

    2004-08-01

    There should have been it for the purpose of the severe handling opening meatus for done study after "The law concerning regulation relating to human cloning techniques and other similar techniques" paid its attention to medical utility of "specified embryo", and having forbidden transplantation to prenatal. There is a problem and asks a law and consistency with "The guidelines for handling of specified embryo" it and, despite the duration, does not get skill. If an ES cell, tissue stem cell and human clone embryo can cry in subject of study as the Trinity, it is not possible for those availability and evaluation of safety. Study of regenerative medicine does not consist last if does not use a cell having gamete, germ, an embryo and the specific character which said. We attention to utility of regenerative medicine and takes a national strategic part, correspondence supporting development of steady study is demanded. The result is reduced to its elements in the future by society.

  9. A Vibration Control Method for the Flexible Arm Based on Energy Migration

    OpenAIRE

    Yushu Bian; Zhihui Gao; Ming Fan

    2015-01-01

    A vibration control method based on energy migration is proposed to decrease vibration response of the flexible arm undergoing rigid motion. A type of vibration absorber is suggested and gives rise to the inertial coupling between the modes of the flexible arm and the absorber. By analyzing 1 : 2 internal resonance, it is proved that the internal resonance can be successfully created and the exchange of vibration energy is existent. Due to the inertial coupling, the damping enhancement effect...

  10. Linear Analysis for Performance of Dual Mass Flywheel with Centrifugal Pendulum Vibration Absorbers System

    Directory of Open Access Journals (Sweden)

    Guangming Zhao

    2013-05-01

    Full Text Available In this study we have offered an investigation of DMF-CPVAs setup for isolating torsional vibration from engine. The simplified mathematical model of DMF-CPVAs setup is built based on the linear theory, the performance of the setup is analyzed, and the result shows that using CPVAs on the DMF leads to an advantage of isolation vibration, instead of just damping vibrations at a specific frequency, could dampen vibrations over a range of frequencies.

  11. Therapeutic modulation of growth factors and cytokines in regenerative medicine.

    Science.gov (United States)

    Ioannidou, Effie

    2006-01-01

    Regeneration that takes place in the human body is limited throughout life. Therefore, when organs are irreparably damaged, they are usually replaced with an artificial device or donor organ. The term "regenerative medicine" covers the restoration or replacement of cells, tissues, and organs. Stem cells play a major role in regenerative medicine by providing the way to repopulate organs damaged by disease. Stem cells have the ability to self renew and to regenerate cells of diverse lineages within the tissue in which they reside. Stem cells could originate from embryos or adult tissues. Growth factors are proteins that may act locally or systemically to affect the growth of cells in several ways. Various cell activities, including division, are influenced by growth factors. Cytokines are a family of low-molecular-weight proteins that are produced by numerous cell types and are responsible for regulating the immune response, inflammation, tissue remodeling and cellular differentiation. Target cells of growth factors and cytokines are mesenchymal, epithelial and endothelial cells. These molecules frequently have overlapping activities and can act in an autocrine or paracrine fashion. A complex network of growth factors and cytokines guides cellular differentiation and regeneration in all organs and tissues. The aim of this paper is to review the role of growth factors and cytokines in different organs or systems and explore their therapeutic application in regenerative medicine. The role of stem cells combined with growth factors and cytokines in the regeneration of vascular and hematopoietic, neural, skeletal, pancreatic, periodontal, and mucosal tissue is reviewed. There is evidence that supports the use of growth factors and cytokines in the treatment of neurological diseases, diabetes, cardiovascular disease, periodontal disease, cancer and its complication, oral mucositis. After solving the ethical issues and establishing clear and reasonable regulations

  12. Stem Cell, Regenerative Medicine and Cancer | Center for Cancer Research

    Science.gov (United States)

    Of the estimated trillion cells that build up our bodies, only a little number can self-renew and give rise to many different cell types. These unspecialized cells are called stem cells. Stem cell division and differentiation is fundamental to the development of the mature organism. Stem cells have recently attracted significant attention largely due to their potential medical benefits in the fields of therapeutic cloning and regenerative medicine.

  13. Preventing Vision Loss from Blast Injuries with Regenerative Biomaterial

    Science.gov (United States)

    2013-08-01

    biomaterial derived from the silk protein fibroin from the Bombyx mori silkworm . This will be the first ophthalmic product that utilizes regenerative silk...the Bombyx mori silkworm cocoon is not toxic and non-immunogenic when placed within the body (1). It is also known that silk fibroin possesses anti...which dissolve silkworm cocoons into an aqueous protein solution (10). The variability in producing silk solution has been a significant challenge for

  14. Carbon nanotube torsional springs for regenerative braking systems

    Science.gov (United States)

    Liu, Sanwei; Martin, Corbin; Lashmore, David; Schauer, Mark; Livermore, Carol

    2015-10-01

    The modeling and demonstration of large stroke, high energy density and high power density torsional springs based on carbon nanotube (CNT) yarns is reported, as well as their application as energy-storing actuators for regenerative braking systems. An originally untwisted CNT yarn is cyclically loaded and unloaded in torsion, with the maximum rotation angle increasing incrementally until failure. The measured average extractable energy density values are 2.9 kJ kg-1  ±  1.2 kJ kg-1 and 3.4 kJ kg-1  ±  0.4 kJ kg-1 for 1-ply CNT yarns and 2-ply CNT yarns, respectively. Additionally, a regenerative braking system is demonstrated to capture the kinetic energy of a wheel and store it as elastic energy in twisted CNT yarns. When the yarn’s twist is released, the stored energy reaccelerates the wheel. The measured energy and mean power densities of the CNT yarns in the simple regenerative braking setup are on average 3.3 kJ kg-1 and 0.67 kW kg-1, respectively, with maximum measured values of up to 4.7 kJ kg-1 and 1.2 kW kg-1, respectively. A slightly lower energy density of up to 1.2 kJ kg-1 and a 0.29 kW kg-1 mean power density are measured for CNT yarns in a more complex setup that mimics a unidirectional rotating regenerative braking mechanism.

  15. Hydrogen-Oxygen PEM Regenerative Fuel Cell Energy Storage System

    Science.gov (United States)

    Bents, David J.; Scullin, Vincent J.; Chang, Bei-Jiann; Johnson, Donald W.; Garcia, Christopher P.

    2005-01-01

    An introduction to the closed cycle hydrogen-oxygen polymer electrolyte membrane (PEM) regenerative fuel cell (RFC), recently constructed at NASA Glenn Research Center, is presented. Illustrated with explanatory graphics and figures, this report outlines the engineering motivations for the RFC as a solar energy storage device, the system requirements, layout and hardware detail of the RFC unit at NASA Glenn, the construction history, and test experience accumulated to date with this unit.

  16. The clinical use of regenerative therapy in COPD

    OpenAIRE

    Lipsi R; Rogliani P; Calzetta L; Segreti A; Cazzola M

    2014-01-01

    Roberto Lipsi,1 Paola Rogliani,1 Luigino Calzetta,2 Andrea Segreti,1 Mario Cazzola1 1Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 2Department of Pulmonary Rehabilitation, San Raffaele Pisana Hospital, Istituti di Ricovero e Cura a Carattere Scientifico, Rome, Italy Abstract: Regenerative or stem cell therapy is an emerging field of treatment based on stimulation of endogenous resident stem cells or administration of exogenous stem cells to treat disea...

  17. A Review of Tooth Discoloration after Regenerative Endodontic Therapy.

    Science.gov (United States)

    Kahler, Bill; Rossi-Fedele, Giampiero

    2016-04-01

    The American Association of Endodontists clinical considerations for regenerative therapy (April 2015) advise of the risk of the possible adverse effect of staining of teeth. It is widely acknowledged that before these guidelines were developed there was no standardized protocol for regenerative therapy, and different approaches using different materials have been reported. The purpose of this review was to undertake a systematic review of published cases to determine the incidence of reported discoloration and examine whether there was any particular association with any material. A PubMed search was performed using key words for regenerative endodontic therapy consistent with prior published systematic reviews. There were 80 studies identified with 379 teeth treated. Many of the studies did not report on the presence or absence of discoloration. It was noted that there was a strong association of discoloration with the use of triple antibiotic paste containing minocycline; however, discoloration was also noted when other materials were used. Unfortunately, bleaching of stained teeth was not predictably achieved in some studies. The use of triple antibiotic paste with minocycline as the intracanal medicament should be reconsidered. Either calcium hydroxide or the double antibiotic paste of metronidazole and ciprofloxacin may limit discoloration. Mineral trioxide aggregate was also associated with discoloration. However, there is little evidence of an alternative superior material as a coronal barrier. Because discoloration is a patient-orientated outcome, further research should document and identify the incidence of discoloration in regenerative endodontic treatment. Copyright © 2016 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  18. The Study of Regenerative Growth and Transdetermination in Drosophila melanogaster

    OpenAIRE

    2013-01-01

    Why some tissues can regenerate, while other cannot is a fundamental question for regenerative medicine. The ability to regenerate at least some tissues is widespread across diverse animals. Some, such as Hydra and planaria can regenerate the majority of their body, while urodele amphibians such as salamanders can regenerate the spinal cord in their tails and also a complete limb. Humans can regenerate tissues such as the liver, muscle and skin. There are diverse mechanisms of regenerations, ...

  19. SULFUR DIOXIDE - SULFUR TRIOXIDE REGENERATIVE FUEL CELL RESEARCH

    Science.gov (United States)

    The thermodynamics and electrolytic characteristics are discussed of an SO2-SO3 regenerative, closed-cycle fuel cell , and summarizes the electrolytic...electrochemical, and phase separation research conducted during a study program to determine the practicability of such a fuel cell . The...experimental results obtained were at such wide variance with the theoretical concept that it became apparent that a fuel cell of this type is not feasible. (Author)

  20. Dedifferentiated fat cells: A cell source for regenerative medicine

    OpenAIRE

    Jumabay, Medet; Boström, Kristina I.

    2015-01-01

    The identification of an ideal cell source for tissue regeneration remains a challenge in the stem cell field. The ability of progeny cells to differentiate into other cell types is important for the processes of tissue reconstruction and tissue engineering and has clinical, biochemical or molecular implications. The adaptation of stem cells from adipose tissue for use in regenerative medicine has created a new role for adipocytes. Mature adipocytes can easily be isolated from adipose cell su...

  1. Empty sky : 9/11 and performing regenerative violence

    OpenAIRE

    Genna, Raimondo

    2010-01-01

    "Empty Sky: 9/11 and Performing Regenerative Violence" explores theatrical depictions of violence and trauma following the events of 11 September 2001 and their relationships to American myth and identity. In the aftermath of the terrorist attack of 9/11, many in the media, from politicians and pundits to journalists and fictional characters in popular television, discussed the epistemological rupture of the event, stating that the world had changed forever and that everything was now differe...

  2. Introducing regenerative design and circularity into architectural and engineering curriculum

    OpenAIRE

    Attia, Shady

    2016-01-01

    Looking today to the challenges for planning and design of sustainable built environment including, carbon emissions, climate change, human health, water problems, biodiversity, scarcity of resources, depletion of fossil fuel, population growth and urbanization; sustainable architecture will play a key role for the sustainable development of society as a whole. In the context of an architectural design studio, this paper presents the experience of introducing the concept of regenerative desig...

  3. Noise and vibration in friction systems

    CERN Document Server

    Sergienko, Vladimir P

    2015-01-01

    The book analyzes the basic problems of oscillation processes and theoretical aspects of noise and vibration in friction systems. It presents generalized information available in literature data and results of the authors in vibroacoustics of friction joints, including car brakes and transmissions. The authors consider the main approaches to abatement of noise and vibration in non-stationary friction processes. Special attention is paid to materials science aspects, in particular to advanced composite materials used to improve the vibroacoustic characteristics of tribopairs The book is intended for researchers and technicians, students and post-graduates specializing in mechanical engineering, maintenance of machines and transport means, production certification, problems of friction and vibroacoustics.

  4. Regenerative medicine in Europe: global competition and innovation governance.

    Science.gov (United States)

    Hogarth, Stuart; Salter, Brian

    2010-11-01

    Leading European nations with strong biotech sectors, such as the UK and Germany, are investing heavily in regenerative medicine, seeking competitive advantage in this emerging sector. However, in the broader biopharmaceutical sector, the EU is outperformed by the USA on all metrics, reflecting longstanding problems: limited venture capital finance, a fragmented patent system, and relatively weak relations between academia and industry. The current global downturn has exacerbated these difficulties. The crisis comes at a time when the EU is reframing its approach to the governance of innovation and renewing its commitment to the goal of making Europe the leading player in the global knowledge economy. If the EU is to gain a competitive advantage in the regenerative medicine sector then it must coordinate a complex multilevel governance framework that encompasses the EU, member states and regional authorities. This article takes stock of Europe's current competitive position within the global bioeconomy, drawing on a variety of metrics in the three intersecting spheres of innovation governance: science, market and society. These data then provide a platform for reviewing the problems of innovation governance faced by the EU and the strategic choices that have to be confronted in the regenerative medicine sector.

  5. Human dental pulp stem cells: Applications in future regenerative medicine.

    Science.gov (United States)

    Potdar, Pravin D; Jethmalani, Yogita D

    2015-06-26

    Stem cells are pluripotent cells, having a property of differentiating into various types of cells of human body. Several studies have developed mesenchymal stem cells (MSCs) from various human tissues, peripheral blood and body fluids. These cells are then characterized by cellular and molecular markers to understand their specific phenotypes. Dental pulp stem cells (DPSCs) are having a MSCs phenotype and they are differentiated into neuron, cardiomyocytes, chondrocytes, osteoblasts, liver cells and β cells of islet of pancreas. Thus, DPSCs have shown great potentiality to use in regenerative medicine for treatment of various human diseases including dental related problems. These cells can also be developed into induced pluripotent stem cells by incorporation of pluripotency markers and use for regenerative therapies of various diseases. The DPSCs are derived from various dental tissues such as human exfoliated deciduous teeth, apical papilla, periodontal ligament and dental follicle tissue. This review will overview the information about isolation, cellular and molecular characterization and differentiation of DPSCs into various types of human cells and thus these cells have important applications in regenerative therapies for various diseases. This review will be most useful for postgraduate dental students as well as scientists working in the field of oral pathology and oral medicine.

  6. Adipose Tissue-Derived Stem Cells in Regenerative Medicine.

    Science.gov (United States)

    Frese, Laura; Dijkman, Petra E; Hoerstrup, Simon P

    2016-07-01

    In regenerative medicine, adult stem cells are the most promising cell types for cell-based therapies. As a new source for multipotent stem cells, human adipose tissue has been introduced. These so called adipose tissue-derived stem cells (ADSCs) are considered to be ideal for application in regenerative therapies. Their main advantage over mesenchymal stem cells derived from other sources, e.g. from bone marrow, is that they can be easily and repeatable harvested using minimally invasive techniques with low morbidity. ADSCs are multipotent and can differentiate into various cell types of the tri-germ lineages, including e.g. osteocytes, adipocytes, neural cells, vascular endothelial cells, cardiomyocytes, pancreatic β-cells, and hepatocytes. Interestingly, ADSCs are characterized by immunosuppressive properties and low immunogenicity. Their secretion of trophic factors enforces the therapeutic and regenerative outcome in a wide range of applications. Taken together, these particular attributes of ADSCs make them highly relevant for clinical applications. Consequently, the therapeutic potential of ADSCs is enormous. Therefore, this review will provide a brief overview of the possible therapeutic applications of ADSCs with regard to their differentiation potential into the tri-germ lineages. Moreover, the relevant advancements made in the field, regulatory aspects as well as other challenges and obstacles will be highlighted.

  7. Arrayed cellular environments for stem cells and regenerative medicine.

    Science.gov (United States)

    Titmarsh, Drew M; Chen, Huaying; Wolvetang, Ernst J; Cooper-White, Justin J

    2013-02-01

    The behavior and composition of both multipotent and pluripotent stem cell populations are exquisitely controlled by a complex, spatiotemporally variable interplay of physico-chemical, extracellular matrix, cell-cell interaction, and soluble factor cues that collectively define the stem cell niche. The push for stem cell-based regenerative medicine models and therapies has fuelled demands for increasingly accurate cellular environmental control and enhanced experimental throughput, driving an evolution of cell culture platforms away from conventional culture formats toward integrated systems. Arrayed cellular environments typically provide a set of discrete experimental elements with variation of one or several classes of stimuli across elements of the array. These are based on high-content/high-throughput detection, small sample volumes, and multiplexing of environments to increase experimental parameter space, and can be used to address a range of biological processes at the cell population, single-cell, or subcellular level. Arrayed cellular environments have the capability to provide an unprecedented understanding of the molecular and cellular events that underlie expansion and specification of stem cell and therapeutic cell populations, and thus generate successful regenerative medicine outcomes. This review focuses on recent key developments of arrayed cellular environments and their contribution and potential in stem cells and regenerative medicine.

  8. Fusion and regenerative therapies: is immortality really recessive?

    Science.gov (United States)

    Stolzing, Alexandra; Hescheler, Jürgen; Sethe, Sebastian

    2007-12-01

    Harnessing cellular fusion as a potential tool for regenerative therapy has been under tentative investigation for decades. A look back the history of fusion experiments in gerontology reveals that whereas some studies indicate that aging-related changes are conserved in fused cells, others have demonstrated that fusion can be used as a tool to revoke cellular senescence and induce tissue regeneration. Recent findings about the role of fusion processes in tissue homeostasis, replenishment, and repair link insights from fusion studies of previous decades with modern developments in stem cell biology and regenerative medicine. We suggest that age-associated loss of regenerative capacity is associated with a decline of effectiveness in stem cell fusion. We project how studies into the fusion of stem cells with tissue cells, or the fusion between activator stem cells and patient cells might help in the development of applications that "rejuvenate" certain target cells, thereby strategically reinstating a regeneration cascade. The outlook is concluded with a discussion of the next research milestones and the potential hazards of fusion therapies.

  9. Clinical Application of Vascular Regenerative Therapy for Peripheral Artery Disease

    Directory of Open Access Journals (Sweden)

    Hiroshi Suzuki

    2013-01-01

    Full Text Available Prognosis of peripheral artery disease (PAD, especially critical limb ischemia, is very poor despite the development of endovascular therapy and bypass surgery. Many patients result in leg amputation and, therefore, vascular regenerative therapy is expected in this field. Gene therapy using vascular endothelial growth factor is the first step of vascular regenerative therapy, but did not confirm effectiveness in a large-scale randomized comparative study. Based on animal experiments, bone marrow mononuclear cells (MNCs, peripheral blood MNCs were used as the cell source for regenerative therapy. Those cells were confirmed to be effective to decrease rest pain and ulcer size, but its effect was not fully satisfied. Mesenchymal stem cells (MSCs are expected as an effective cell source for vascular regeneration and clinical studies are ongoing, because the cells are able to differentiate into various cell types and produce a significant amount of vascular growth factors. Of vascular regeneration therapy, peripheral MNCs and bone marrow MNCs were recognized as advanced medical technology but do not attain to the standard therapy. However, clinical use of MSCs have already started, and induced pluripotent stem cells are surely promising tool for vascular regeneration therapy although further basic studies are required for clinical application.

  10. Leptin Effects on the Regenerative Capacity of Human Periodontal Cells

    Directory of Open Access Journals (Sweden)

    Marjan Nokhbehsaim

    2014-01-01

    Full Text Available Obesity is increasing throughout the globe and characterized by excess adipose tissue, which represents a complex endocrine organ. Adipose tissue secrets bioactive molecules called adipokines, which act at endocrine, paracrine, and autocrine levels. Obesity has recently been shown to be associated with periodontitis, a disease characterized by the irreversible destruction of the tooth-supporting tissues, that is, periodontium, and also with compromised periodontal healing. Although the underlying mechanisms for these associations are not clear yet, increased levels of proinflammatory adipokines, such as leptin, as found in obese individuals, might be a critical pathomechanistic link. The objective of this study was to examine the impact of leptin on the regenerative capacity of human periodontal ligament (PDL cells and also to study the local leptin production by these cells. Leptin caused a significant downregulation of growth (TGFβ1, and VEGFA and transcription (RUNX2 factors as well as matrix molecules (collagen, and periostin and inhibited SMAD signaling under regenerative conditions. Moreover, the local expression of leptin and its full-length receptor was significantly downregulated by inflammatory, microbial, and biomechanical signals. This study demonstrates that the hormone leptin negatively interferes with the regenerative capacity of PDL cells, suggesting leptin as a pathomechanistic link between obesity and compromised periodontal healing.

  11. Aerospace and maritime applications for solid oxide regenerative fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Sridhar, K.R.; McElroy, J. [Ion America Corporation, Sunnyvale, CA (United States)

    2005-07-01

    Solid Oxide Regenerative Fuel Cells (SORFC's) have been demonstrated for over 1000 hours of operation at degradation rates as low as 0.5% per 1000 hours for current densities as high as 300mA/cm2. Efficiency levels (fuel cell power out vs. electrolysis power in) have been demonstrated as high as 70% at 300mA/cm2. These attributes now make the SORFC a leading candidate for many applications not previously considered viable for the regenerative fuel cell approach. The SORFC has several distinct advantages in comparison with the familiar PEM regenerative fuel cell. Among the advantages are; oxidant electrode reversibility, water independence with open oxidant chambers, ability to operate at very low oxidant pressures, near unity current efficiency, and ability to electrolyze carbon dioxide as well as water. Additionally, a single SORFC stack can accomplish all of the above. With the aforementioned demonstrations and technical advantages various aerospace and maritime applications have become very attractive for the SORFC. At high altitude in the earth's atmosphere the SORFC can breathe the rare air with only a small performance penalty. In the space arena the SORFC can produce CO and oxygen from the Martian atmospheric carbon dioxide and alternately produce electricity from those reactant stores. In nuclear submarines the SORFC can produce pure oxygen by electrolysis of expired carbon dioxide and alternately produce electricity. In Unmanned Underwater Vehicles (UUVs) the SORFC can enable the desired range because of the very high energy density. (orig.)

  12. Ultrastructural study of the chromatoid body in planarian regenerative cells

    Energy Technology Data Exchange (ETDEWEB)

    Hori, I. (Kanazawa Medical Univ., Ishikawa (Japan))

    1982-04-01

    The present paper deals with the ultrastructural changes of chromatoid bodies in planarian regenerative cells under normal and experimental conditions. A close relationship was usually observed between chromatoid bodies and pore regions of the nuclear envelope in these cells. The chromatoid bodies continued to decrease in size during cytodifferentiation of regenerative cells, though they did not disappear entirely throughout the regeneration processes. Cytochemistry and (/sup 3/H)uridine autoradiography have shown that the chromatoid body contains RNA. The typical morphological effect of actinomycin D became apparent in three organelles, i.e., nucleolus, polysome and chromatoid body. Ultrastructural changes in nucleoli were observed to occur after actinomycin treatment (20 ..mu..g/ml). The exposure to a higher dose of actinomycin (50 ..mu..g/ml) caused a decay of chromatoid bodies while nuclear envelopes retained numerous pores. Both the nucleoli and the chromatoid bodies disappeared in the sequential stages. Within the cytoplasm of such cells disintegration of a polysomal pattern was correlated with the disappearance of chromatoid bodies. The significance of the planarian chromatoid body is discussed in relation to differentiation of the regenerative cells.

  13. Energy-Regenerative Braking Control of Electric Vehicles Using Three-Phase Brushless Direct-Current Motors

    Directory of Open Access Journals (Sweden)

    Bo Long

    2013-12-01

    Full Text Available Regenerative braking provides an effective way of extending the driving range of battery powered electric vehicles (EVs. This paper analyzes the equivalent power circuit and operation principles of an EV using regenerative braking control technology. During the braking period, the switching sequence of the power converter is controlled to inverse the output torque of the three-phase brushless direct-current (DC motor, so that the braking energy can be returned to the battery. Compared with the presented methods, this technology can achieve several goals: energy recovery, electric braking, ultra-quiet braking and extending the driving range. Merits and drawbacks of different braking control strategy are further elaborated. State-space model of the EVs under energy-regenerative braking operation is established, considering that parameter variations are unavoidable due to temperature change, measured error, un-modeled dynamics, external disturbance and time-varying system parameters, a sliding mode robust controller (SMRC is designed and implemented. Phase current and DC-link voltage are selected as the state variables, respectively. The corresponding control law is also provided. The proposed control scheme is compared with a conventional proportional-integral (PI controller. A laboratory EV for experiment is setup to verify the proposed scheme. Experimental results show that the drive range of EVs can be improved about 17% using the proposed controller with energy-regeneration control.

  14. Regenerative Medicine in Rotator Cuff Injuries

    Directory of Open Access Journals (Sweden)

    Pietro Randelli

    2014-01-01

    Full Text Available Rotator cuff injuries are a common source of shoulder pathology and result in an important decrease in quality of patient life. Given the frequency of these injuries, as well as the relatively poor result of surgical intervention, it is not surprising that new and innovative strategies like tissue engineering have become more appealing. Tissue-engineering strategies involve the use of cells and/or bioactive factors to promote tendon regeneration via natural processes. The ability of numerous growth factors to affect tendon healing has been extensively analyzed in vitro and in animal models, showing promising results. Platelet-rich plasma (PRP is a whole blood fraction which contains several growth factors. Controlled clinical studies using different autologous PRP formulations have provided controversial results. However, favourable structural healing rates have been observed for surgical repair of small and medium rotator cuff tears. Cell-based approaches have also been suggested to enhance tendon healing. Bone marrow is a well known source of mesenchymal stem cells (MSCs. Recently, ex vivo human studies have isolated and cultured distinct populations of MSCs from rotator cuff tendons, long head of the biceps tendon, subacromial bursa, and glenohumeral synovia. Stem cells therapies represent a novel frontier in the management of rotator cuff disease that required further basic and clinical research.

  15. Regenerative Medicine in Rotator Cuff Injuries

    Science.gov (United States)

    Randelli, Pietro; Ragone, Vincenza; Menon, Alessandra; Cabitza, Paolo; Banfi, Giuseppe

    2014-01-01

    Rotator cuff injuries are a common source of shoulder pathology and result in an important decrease in quality of patient life. Given the frequency of these injuries, as well as the relatively poor result of surgical intervention, it is not surprising that new and innovative strategies like tissue engineering have become more appealing. Tissue-engineering strategies involve the use of cells and/or bioactive factors to promote tendon regeneration via natural processes. The ability of numerous growth factors to affect tendon healing has been extensively analyzed in vitro and in animal models, showing promising results. Platelet-rich plasma (PRP) is a whole blood fraction which contains several growth factors. Controlled clinical studies using different autologous PRP formulations have provided controversial results. However, favourable structural healing rates have been observed for surgical repair of small and medium rotator cuff tears. Cell-based approaches have also been suggested to enhance tendon healing. Bone marrow is a well known source of mesenchymal stem cells (MSCs). Recently, ex vivo human studies have isolated and cultured distinct populations of MSCs from rotator cuff tendons, long head of the biceps tendon, subacromial bursa, and glenohumeral synovia. Stem cells therapies represent a novel frontier in the management of rotator cuff disease that required further basic and clinical research. PMID:25184132

  16. Vibrationally Resolved Electron Transfer Rates in Solution

    Science.gov (United States)

    Spears, Kenneth G.

    2002-03-01

    We have re-examined our earlier report of electron transfer in the [Co(Cp)_2|V(CO)_6] radical-pair using ultrafast infrared transient absorption spectroscopy in room temperature solutions. The radical-pair is created from the [Co(Cp)_2^+|V(CO)_6^-] ion-pair by ultrafast visible charge-transfer excitation. Transient absorption experiments with ps time constants. A small ET component with a 75 ps time constant is due to some separation and reformation of the radical-pairs. Transient absorption experiments monitoring the recovery of the ion-pair state shows that both fast components are due to ET rather than some other vibrational relaxation (VR) process in the radical state. We analyze the visible charge-transfer band and assign the two fast ET decay times to two ion-pair contact geometries with absorption origins different by about 1250 ± 350 cm-1. For excitation at 800 and 700 nm the 700 fs ET lifetime depends on the vibrational quantum state of the nontotally symmetric CO stretch in the V(CO)6 radical, where the lifetime decreases by 10% for the first vibrational quantum and 45% for the second quantum. There is no quantum effect for the second ion-pair geometry with a 5 ps ET lifetime. Standard ET rate models cannot explain the rate dependence upon vibrational quantum state for a nontotally symmetric vibration, and it may arise from a breakdown of the Condon approximation. We also report rates for IVR of CO stretching modes and for VR of low frequency vibrations. At excitation wavelengths of 620 and 555 nm there is sufficient internal vibrational energy in low-frequency vibrations to cause geometric inter-conversion between energetically similar Jahn-Teller geometries in the V(CO)6 radical. This process creates a 200 fs rise time for the V(CO)6 radical species to assume a stable geometry, which requires VR of low frequency vibrations to the solvent. These results demonstrate that earlier ET measurements from our group on the same molecule had insufficient time

  17. Simulation and test for hydraulic electromagnetic energy-regenerative shock absorber%液电式馈能减振器外特性仿真与试验

    Institute of Scientific and Technical Information of China (English)

    张晗; 过学迅; 徐琳; 张杰

    2014-01-01

    With the rising concerns of global environmental issues, energy saving in automobiles becomes an important subject. In order to achieve the purpose of vibration reduction, the traditional passive shock absorber converts the vehicle vibration energy to thermal energy, and then the thermal energy is released into the air. However, the energy-regenerative shock absorber could harvest this part of the energy. This paper presents a vehicular hydraulic electromagnetic energy-regenerative shock absorber (HESA) which is designed for acquiring the vibration energy caused by road irregularity. It is composed of a hydraulic cylinder, two check valves, two accumulators, a hydraulic motor, a generator, and hydraulic lines. When the vehicle is subjected to vertical vibration, the oil in the HESA flows to the hydraulic motor through a hydraulic line, then the rotating hydraulic motor drives a generator to produce electricity. In order to consider the vibration reduction performance of the HESA, the damping characteristic was analyzed in detail. Through theoretical analysis, the damping force mathematical model of the HESA was deduced, and the calculation program was written in MATLAB, based on the HESA damping force mathematical model. The indicator diagram characteristic and speed characteristic of the HESA under the working condition of a sinusoidal displacement input of 1.67Hz was obtained from simulation tests, which was designed according to a national absorber test procedure. A test bench was constructed to verify the results of a simulation. The comparison between the bench test data and simulation data showed that the value of a compression travel damping force was smaller than the rebound travel’s, and the peak value of the simulation data was identical with the value in test data. The simulation speed characteristic curve of the HESA was compared with the bench test data. However, there were some distortions in the test indicator diagram characteristic curve because

  18. VLTI-UT vibrations effort and performances

    Science.gov (United States)

    Poupar, Sébastien; Haguenauer, Pierre; Alonso, Jaime; Schuhler, Nicolas; Henriquez, Juan-Pablo; Berger, Jean-Philippe; Bourget, Pierre; Brillant, Stephane; Castillo, Roberto; Gitton, Philippe; Gonte, Frederic; Di Lieto, Nicola; Lizon, Jean-Louis; Merand, Antoine; Woillez, Julien

    2014-07-01

    The ESO Very Large Telescope Interferometer (VLTI) using the Unit Telescope (UT) was strongly affected by vibrations since the first observations. Investigation by ESO on that subject had started in 2007, with a considerable effort since mid 2008. An important number of investigations on various sub-systems (On telescope: Guiding, Passive supports, Train Coude, insulation of electronics cabinets; On Instruments: dedicated campaign on each instruments with a special attention on the ones equipped with Close Cycle Cooler) were realized. Vibrations were not only recorded and analyzed using the usual accelerometers but also using on use sub-systems as InfRared Image Sensor (IRIS) and Multiple Applications Curvature Adaptive Optics (MACAO) and using a specific tool developed for vibrations measurements Mirror vibrAtion Metrology systeM for the Unit Telescope (MAMMUT). Those tools and systems have been used in order to improve the knowledge on telescope by finding sources. The sources whenever it was possible were damped. As known for years, instruments are still the principal sources of vibrations, for the majority of the UT. A special test in which 2 UTs instruments were completely shut down was realized to determine the minimum Optical Path Length (OPL) achievable. Vibrations is now a part of the instruments interface document and during the installation of any new instrument (KMOS) or system (AOF) a test campaign is realized. As a result some modifications (damping of CCC) can be asked in case of non-compliance. To ensure good operational conditions, levels of vibrations are regularly recorded to control any environmental change.

  19. Analysis of real-time vibration data

    Science.gov (United States)

    Safak, E.

    2005-01-01

    In recent years, a few structures have been instrumented to provide continuous vibration data in real time, recording not only large-amplitude motions generated by extreme loads, but also small-amplitude motions generated by ambient loads. The main objective in continuous recording is to track any changes in structural characteristics, and to detect damage after an extreme event, such as an earthquake or explosion. The Fourier-based spectral analysis methods have been the primary tool to analyze vibration data from structures. In general, such methods do not work well for real-time data, because real-time data are mainly composed of ambient vibrations with very low amplitudes and signal-to-noise ratios. The long duration, linearity, and the stationarity of ambient data, however, allow us to utilize statistical signal processing tools, which can compensate for the adverse effects of low amplitudes and high noise. The analysis of real-time data requires tools and techniques that can be applied in real-time; i.e., data are processed and analyzed while being acquired. This paper presents some of the basic tools and techniques for processing and analyzing real-time vibration data. The topics discussed include utilization of running time windows, tracking mean and mean-square values, filtering, system identification, and damage detection.

  20. Distributed electric absorbers of beam vibrations

    Science.gov (United States)

    dell'lsola, Francesco; Del Vescovo, Dionisio; Maurini, Corrado

    2003-07-01

    Several electric vibration absorbers based on distributed piezoelectric control of beam vibrations are studied. The damping devices are conceived by interconnecting with different modular electric networks an array of piezoelectric transducers uniformly distributed on a beam. Five different vibration absorbers made of five different network interconnecting topologies are considered and their damping performances are analyzed and compared. The analysis is based on homogenized models of modular piezo-electromechanical systems. The optimal parameters of these absorbers are found by adopting the criterion of critical damping of waves with a single wave number. We show that: i) there is an interconnecting network providing an optimal multimodal damping; ii) the performances required to the electr(on)ic components can be significantly decreased by increasing the number (and decreasing the dimensions) of the piezoelectric transducers.

  1. Vibration Based Sun Gear Damage Detection

    Science.gov (United States)

    Hood, Adrian; LaBerge, Kelsen; Lewicki, David; Pines, Darryll

    2013-01-01

    Seeded fault experiments were conducted on the planetary stage of an OH-58C helicopter transmission. Two vibration based methods are discussed that isolate the dynamics of the sun gear from that of the planet gears, bearings, input spiral bevel stage, and other components in and around the gearbox. Three damaged sun gears: two spalled and one cracked, serve as the focus of this current work. A non-sequential vibration separation algorithm was developed and the resulting signals analyzed. The second method uses only the time synchronously averaged data but takes advantage of the signal/source mapping required for vibration separation. Both algorithms were successful in identifying the spall damage. Sun gear damage was confirmed by the presence of sun mesh groups. The sun tooth crack condition was inconclusive.

  2. Nanometer Vibration Control by Computer Feedback

    Science.gov (United States)

    McLeod, Kevin; Schramm, Steven; McKenna, Janis; Mattison, Thomas

    2008-05-01

    The International Linear Collider is a planned electron-positron accelerator at the 500 GeV scale. Colliding nanometer sized beams requires control of vibrations of the final focusing magnets at the nanometer level. We are investigating position measurement with laser interferometry and position control with piezoelectric actuators using state-vector feedback in a near-real-time Linux computing environment. A custom driver for a commercial ADC-DAC card has the interferometer reconstruction and feedback algorithms inside an interrupt handler running at 10 kHz. Linux user applications interact with the driver for interferometer alignment and calibration, measurement of excitation of internal modes by the piezo, and measurement of external vibration spectrum. Other applications analyze the internal and external vibration modes, and calculate state-vector feedback gains. Graphical interface is provided by tcl/tk. Code development is in C with standard GNU tools, using a recursive generic makefile.

  3. Vibration-type particle separation device with piezoceramic vibrator

    Science.gov (United States)

    Ooe, Katsutoshi; Doi, Akihiro

    2008-12-01

    During hemanalysis, it is necessary to separate blood cells from whole blood. Many blood separation methods, for example, centrifugation and filtering, are in practical use. However, the use of these methods involves problems from the perspectives of processing speed and processing volume. We develop new types of blood separation devices that use piezo-ceramic vibrators. The first device uses a capillary. One end of the capillary is fixed to the device frame, and the other is fixed to a piezo-ceramic vibrator. The vibrator transmits bending waves to the capillary. This device can process only a small amount of solution; therefore, it is not suitable for hemanalysis. In order to solve this problem, we developed a second device; this device has a pair of thin glass plates with a small gap as a substitute for the capillary used in the first device. These devices are based on the fact that particles heavier than water move toward transverse velocity antinodes while those lighter than water move toward velocity nodes. In this report, we demonstrate the highspeed separation of silica microbeads and 50-vol% glycerol water by using these devices. The first device can separate the abovementioned solution within 3 min while the second can separate it within 1 min. Both devices are driven by a rectangular wave of 15 to 20 Vpp. Furthermore, it has been confirmed that red blood cells are separated from diluted whole blood using the first device within approximately 1 min. These devices have transparency, so they can compose as the analysis system with the chemical analyzer easily.

  4. Vibration Isolation for Parallel Hydraulic Hybrid Vehicles

    Directory of Open Access Journals (Sweden)

    The M. Nguyen

    2008-01-01

    Full Text Available In recent decades, several types of hybrid vehicles have been developed in order to improve the fuel economy and to reduce the pollution. Hybrid electric vehicles (HEV have shown a significant improvement in fuel efficiency for small and medium-sized passenger vehicles and SUVs. HEV has several limitations when applied to heavy vehicles; one is that larger vehicles demand more power, which requires significantly larger battery capacities. As an alternative solution, hydraulic hybrid technology has been found effective for heavy duty vehicle because of its high power density. The mechanical batteries used in hydraulic hybrid vehicles (HHV can be charged and discharged remarkably faster than chemical batteries. This feature is essential for heavy vehicle hybridization. One of the main problems that should be solved for the successful commercialization of HHV is the excessive noise and vibration involving with the hydraulic systems. This study focuses on using magnetorheological (MR technology to reduce the noise and vibration transmissibility from the hydraulic system to the vehicle body. In order to study the noise and vibration of HHV, a hydraulic hybrid subsystem in parallel design is analyzed. This research shows that the MR elements play an important role in reducing the transmitted noise and vibration to the vehicle body. Additionally, locations and orientations of the isolation system also affect the efficiency of the noise and vibration mitigation. In simulations, a skyhook control algorithm is used to achieve the highest possible effectiveness of the MR isolation system.

  5. Broadband seismic effects from train vibrations

    Science.gov (United States)

    Fuchs, Florian; Bokelmann, Götz

    2017-04-01

    Seismologists rarely study train induced vibrations which are mainly regarded an unwanted source of noise for classical seismological applications such as earthquake monitoring. A few seismological studies try to utilize train vibrations however as active sources, e.g. for subsurface imaging, but they do not focus on the characteristics of the train signal itself. Most available studies on train induced vibrations take an engineering approach and aim at better understanding the generation and short-distance propagation of train induced vibrations, mainly for mitigation and construction purposes. They mostly rely on numerical simulations and/or short-period or accelerometer recordings obtained directly on the train track or up to few hundred meters away and almost no studies exist with seismic recordings further away from the track. In some of these previous studies sharp and equidistant peaks are present in the vibration spectrum of heavy freight trains, but they do not attempt to explain them. Here we show and analyze various train vibration signals obtained from a set of seismic broadband stations installed in the context of the temporary, large-scale regional seismic network AlpArray. The geometrical restrictions of this seismic network combined with budget and safety considerations resulted in a number of broad-band instruments deployed in the vicinity of busy railway lines. On these stations we observe very characteristic seismic signals associated with different types of trains, typically showing pronounced equidistant spectral lines over a wide frequency range. In this study we analyze the nature of such signals and discuss if they are generated by a source effect or by wave propagation effects in near-surface soil layers.

  6. Hydrogenation reaction characteristics and properties of its hydrides for magnetic regenerative material HoCu2

    Institute of Scientific and Technical Information of China (English)

    金滔; 吴梦茜; 黄迦乐; 汤珂; 陈立新

    2016-01-01

    The hydrogenation reaction characteristics and the properties of its hydrides for the magnetic regenerative material HoCu2 (CeCu2-type) of a cryocooler were investigated. The XRD testing reveals that the hydrides of HoCu2 were a mixture of Cu, unknown hydride I, and unknown hydride II. Based on the PCT (pressure−concentration−temperature) curves under different reaction temperatures, the relationships among reaction temperature, equilibrium pressure, and maximum hydrogen absorption capacity were analyzed and discussed. The enthalpy changeΔH and entropy changeΔS as a result of the whole hydrogenation process were also calculated from the PCT curves. The magnetization and volumetric specific heat capacity of the hydride were also measured by SQUID magnetometer and PPMS, respectively.

  7. Analyzing Peace Pedagogies

    Science.gov (United States)

    Haavelsrud, Magnus; Stenberg, Oddbjorn

    2012-01-01

    Eleven articles on peace education published in the first volume of the Journal of Peace Education are analyzed. This selection comprises peace education programs that have been planned or carried out in different contexts. In analyzing peace pedagogies as proposed in the 11 contributions, we have chosen network analysis as our method--enabling…

  8. Dynamic simulation on effect of flame arrangement on thermal process of regenerative reheating furnace

    Institute of Scientific and Technical Information of China (English)

    OU Jian-ping; MA Ai-chun; ZHAN Shu-hua; ZHOU Jie-min; XIAO Ze-qiang

    2007-01-01

    By analyzing the characteristics of combustion and billet heating process, a 3-D transient computer fluid dynamic simulation system based on commercial software CFX4.3 and some self-programmed codes were developed to simulate the thermal process in a continuous heating furnace using high temperature air combustion technology. The effects of different switching modes on injection entrancement of multi burners, combustion and billet heating process in furnace were analyzed numerically, and the computational results were compared with on-site measurement, which verified the practicability of this numerical simulation system.The results indicate that the flow pattern and distribution of temperature in regenerative reheating furnace with partial same-side-switching combustion mode are favorable to satisfy the high quality requirements of reheating, in which the terminal heating temperature of billets is more than 1 460 K and the temperature difference between two nodes is not more than 10 K. But since the surface average temperature of billets apart from heating zone is only about 1 350 K and continued heating is needed in soaking zone, the design and operation of current state are still needed to be optimized to improve the temperature schedule of billet heating. The distribution of velocity and temperature in regenerative reheating furnace with same-side-switching combustion mode cannot satisfy the even and fast heating process. The terminal heating temperature of billets is lower than that of the former case by 30 K. The distribution of flow and temperature can be improved by using cross-switching combustion mode, whose terminal temperature of billets is about 1 470 K with small temperature difference within 10 K.

  9. A Vibration Control Method for the Flexible Arm Based on Energy Migration

    Directory of Open Access Journals (Sweden)

    Yushu Bian

    2015-01-01

    Full Text Available A vibration control method based on energy migration is proposed to decrease vibration response of the flexible arm undergoing rigid motion. A type of vibration absorber is suggested and gives rise to the inertial coupling between the modes of the flexible arm and the absorber. By analyzing 1 : 2 internal resonance, it is proved that the internal resonance can be successfully created and the exchange of vibration energy is existent. Due to the inertial coupling, the damping enhancement effect is revealed. Via the inertial coupling, vibration energy of the flexible arm can be dissipated by not only the damping of the vibration absorber but also its own enhanced damping, thereby effectively decreasing vibration. Through numerical simulations and analyses, it is proven that this method is feasible in controlling nonlinear vibration of the flexible arm undergoing rigid motion.

  10. Development of a Semi-Active Electromagnetic Vibration Absorber and Its Experimental Study.

    Science.gov (United States)

    Liu, Xueguang; Feng, Xiaoxiao; Shi, Ye; Wang, Ye; Shuai, Zhijun

    2013-10-01

    In this work, a semiactive electromagnetic vibration absorber has been developed based on a proposed electromagnetic stiffness adjustable spring model, which presents a new solution for adjusting stiffness in the field of vibration absorber devices. Simulation study on the electromagnetic spring has been performed to determine the structural parameter of the semiactive vibration absorber. An experimental rig is also built up to investigate its practical vibration control effectiveness. Firstly, the finite element model of the test bench is used to analyze its vibration characteristics. Then, the vibration reduction effect is predicted through the simulation analysis, from which the optimal control positions are found. Finally, the experimental studies are also conducted, and the results show that this semiactive electromagnetic vibration absorber has a frequency adjustment range from 21 Hz to 25 Hz, in which considerable vibration reduction from 5 dB to 10 dB can be achieved.

  11. Vibration control of ELTs

    Science.gov (United States)

    Pott, J.-U.

    2011-09-01

    MPIA is the PI institute of the MCAO-supported Fizeau imager LINC-NIRVANA at the LBT, and a partner of the E-ELT first light NIR imager MICADO (both SCAO and MCAO assisted). LINC-NIRVANA is a true pathfinder for future ELT-AO imagers both in terms of size and technology. I will present our vibration control strategies, involving accelerometer based real-time vibration measurements, feedforward and feedback optical path control, predictive filtering, vibration sensitive active control of actuators, and the development of a dynamical model of the entire telescope. Our experiences, made with LINC-NIRVANA, will be fed into the MICADO structural AO design to reach highest on-sky sensitivity.

  12. Vibration suppression for laminated composite plates with arbitrary boundary conditions

    Science.gov (United States)

    Li, J.; Narita, Y.

    2013-11-01

    An analysis of vibration suppression for laminated composite plates subject to active constrained layer damping under various boundary conditions is presented. Piezoelectric-fiber-reinforced composites (PFRCs) are used as active actuators, and the effect of PFRC patches on vibration control is reported here. An analytical approach is expanded to analyze the vibration of laminated composites with arbitrary boundary conditions. By using Hamilton's principle and the Rayleigh-Ritz method, the equation of motion for the resulting electromechanical coupling system is derived. A velocity feedback control rule is employed to obtain an effective active damping in the vibration control. The orientation effect of piezoelectric fibers in the PFRC patches on the suppression of forced vibrations is also investigated.

  13. Axial vibration analysis of nanocones based on nonlocal elasticity theory

    Institute of Scientific and Technical Information of China (English)

    Shu-Qi Guo; Shao-Pu Yang

    2012-01-01

    Carbon nanocones have quite fascinating electronic and structural properties,whose axial vibration is seldom investigated in previous studies.In this paper,based on a nonlocal elasticity theory,a nonuniform rod model is applied to investigate the small-scale effect and the nonuniform effect on axial vibration of nanocones.Using the modified Wentzel-Brillouin-Kramers (WBK) method,an asymptotic solution is obtained for the axial vibration of general nonuniform nanorods.Then,using similar procedure,the axial vibration of nanocones is analyzed for nonuniform parameters,mode number and nonlocal parameters.Explicit expressions are derived for mode frequencies of clamped-clamped and clamped-free boundary conditions.It is found that axial vibration frequencies are highly overestimated by the classical rod model because of ignorance of the effect of small length scale.

  14. Design of a nonlinear torsional vibration absorber

    Science.gov (United States)

    Tahir, Ammaar Bin

    larger than that in the latter. A nonlinear absorber design has been proposed comprising of thin beams as elastic elements. The geometric configuration of the proposed design has been shown to provide cubic stiffness nonlinearity in torsion. The values of design variables, namely the strength of nonlinearity alpha and torsional stiffness kalpha, were obtained by optimizing dimensions and material properties of the beams for a maximum vibration energy dissipation in the nonlinear absorber. A parametric study has also been conducted to analyze the effect of the magnitude of excitation provided to the system on the performance of a nonlinear absorber. It has been shown that the nonlinear absorber turns out to be more effective in terms of energy dissipation as compared to a linear absorber with an increase in the excitation level applied to the system.

  15. The Intermodulation Lockin Analyzer

    CERN Document Server

    Tholen, Erik A; Forchheimer, Daniel; Schuler, Vivien; Tholen, Mats O; Hutter, Carsten; Haviland, David B

    2011-01-01

    Nonlinear systems can be probed by driving them with two or more pure tones while measuring the intermodulation products of the drive tones in the response. We describe a digital lock-in analyzer which is designed explicitly for this purpose. The analyzer is implemented on a field-programmable gate array, providing speed in analysis, real-time feedback and stability in operation. The use of the analyzer is demonstrated for Intermodulation Atomic Force Microscopy. A generalization of the intermodulation spectral technique to arbitrary drive waveforms is discussed.

  16. Analyzing in the present

    DEFF Research Database (Denmark)

    Revsbæk, Line; Tanggaard, Lene

    2015-01-01

    The article presents a notion of “analyzing in the present” as a source of inspiration in analyzing qualitative research materials. The term emerged from extensive listening to interview recordings during everyday commuting to university campus. Paying attention to the way different parts...... the interdependency between researcher and researched. On this basis, we advocate an explicit “open-state-of mind” listening as a key aspect of analyzing qualitative material, often described only as a matter of reading transcribed empirical materials, reading theory, and writing. The article contributes...

  17. Vibrations and waves

    CERN Document Server

    Kaliski, S

    2013-01-01

    This book gives a comprehensive overview of wave phenomena in different media with interacting mechanical, electromagnetic and other fields. Equations describing wave propagation in linear and non-linear elastic media are followed by equations of rheological models, models with internal rotational degrees of freedom and non-local interactions. Equations for coupled fields: thermal, elastic, electromagnetic, piezoelectric, and magneto-spin with adequate boundary conditions are also included. Together with its companion volume Vibrations and Waves. Part A: Vibrations this work provides a wealth

  18. Vibrational spectroscopy of resveratrol

    Science.gov (United States)

    Billes, Ferenc; Mohammed-Ziegler, Ildikó; Mikosch, Hans; Tyihák, Ernő

    2007-11-01

    In this article the authors deal with the experimental and theoretical interpretation of the vibrational spectra of trans-resveratrol (3,5,4'-trihydroxy- trans-stilbene) of diverse beneficial biological activity. Infrared and Raman spectra of the compound were recorded; density functional calculations were carried out resulting in the optimized geometry and several properties of the molecule. Based on the calculated force constants, a normal coordinate analysis yielded the character of the vibrational modes and the assignment of the measured spectral bands.

  19. Vibrational Collapse of Hexapod Packings

    Science.gov (United States)

    Zhao, Yuchen; Ding, Jingqiu; Barés, Jonathan; Dierichs, Karola; Behringer, Robert

    2016-11-01

    Columns made of convex noncohesive grains like sand collapse after being released from a confining container. However, structures built from concave grains can be stable without external support. Previous research show that the stability of the columns depends on column diameter and height, by observing column stability after carefully lifting their confinement tubes. Thinner and taller columns collapse with higher probability. While the column stability weakly depends on packing density, it strongly depends on inter-particle friction. Experiments that cause the column to collapse also reveal similar trends, as more effort (such as heavier loading or shearing) is required to destabilize columns that are intrinsically more stable. In the current experiments, we invesitage the effect of vibration on destructing a column. Short columns collapse following the relaxation dynamics of disorder systems, which coincides with similar experiments on staple packings. However, tall columns collapse faster at the beginning, in addition to the relaxation process coming after. Using high-speed imaging, we analyze column collapse data from different column geometries. Ongoing work is focusing on characterizing the stability of hexapod packings to vibration. We thanks NSF-DMR-1206351 and the William M. Keck Foundation.

  20. Analyzing binding data.

    Science.gov (United States)

    Motulsky, Harvey J; Neubig, Richard R

    2010-07-01

    Measuring the rate and extent of radioligand binding provides information on the number of binding sites, and their affinity and accessibility of these binding sites for various drugs. This unit explains how to design and analyze such experiments.

  1. Analog multivariate counting analyzers

    CERN Document Server

    Nikitin, A V; Armstrong, T P

    2003-01-01

    Characterizing rates of occurrence of various features of a signal is of great importance in numerous types of physical measurements. Such signal features can be defined as certain discrete coincidence events, e.g. crossings of a signal with a given threshold, or occurrence of extrema of a certain amplitude. We describe measuring rates of such events by means of analog multivariate counting analyzers. Given a continuous scalar or multicomponent (vector) input signal, an analog counting analyzer outputs a continuous signal with the instantaneous magnitude equal to the rate of occurrence of certain coincidence events. The analog nature of the proposed analyzers allows us to reformulate many problems of the traditional counting measurements, and cast them in a form which is readily addressed by methods of differential calculus rather than by algebraic or logical means of digital signal processing. Analog counting analyzers can be easily implemented in discrete or integrated electronic circuits, do not suffer fro...

  2. Miniature mass analyzer

    CERN Document Server

    Cuna, C; Lupsa, N; Cuna, S; Tuzson, B

    2003-01-01

    The paper presents the concept of different mass analyzers that were specifically designed as small dimension instruments able to detect with great sensitivity and accuracy the main environmental pollutants. The mass spectrometers are very suited instrument for chemical and isotopic analysis, needed in environmental surveillance. Usually, this is done by sampling the soil, air or water followed by laboratory analysis. To avoid drawbacks caused by sample alteration during the sampling process and transport, the 'in situ' analysis is preferred. Theoretically, any type of mass analyzer can be miniaturized, but some are more appropriate than others. Quadrupole mass filter and trap, magnetic sector, time-of-flight and ion cyclotron mass analyzers can be successfully shrunk, for each of them some performances being sacrificed but we must know which parameters are necessary to be kept unchanged. To satisfy the miniaturization criteria of the analyzer, it is necessary to use asymmetrical geometries, with ion beam obl...

  3. Multivariate Analysis of Ladle Vibration

    Science.gov (United States)

    Yenus, Jaefer; Brooks, Geoffrey; Dunn, Michelle

    2016-08-01

    The homogeneity of composition and uniformity of temperature of the steel melt before it is transferred to the tundish are crucial in making high-quality steel product. The homogenization process is performed by stirring the melt using inert gas in ladles. Continuous monitoring of this process is important to make sure the action of stirring is constant throughout the ladle. Currently, the stirring process is monitored by process operators who largely rely on visual and acoustic phenomena from the ladle. However, due to lack of measurable signals, the accuracy and suitability of this manual monitoring are problematic. The actual flow of argon gas to the ladle may not be same as the flow gage reading due to leakage along the gas line components. As a result, the actual degree of stirring may not be correctly known. Various researchers have used one-dimensional vibration, and sound and image signals measured from the ladle to predict the degree of stirring inside. They developed online sensors which are indeed to monitor the online stirring phenomena. In this investigation, triaxial vibration signals have been measured from a cold water model which is a model of an industrial ladle. Three flow rate ranges and varying bath heights were used to collect vibration signals. The Fast Fourier Transform was applied to the dataset before it has been analyzed using principal component analysis (PCA) and partial least squares (PLS). PCA was used to unveil the structure in the experimental data. PLS was mainly applied to predict the stirring from the vibration response. It was found that for each flow rate range considered in this study, the informative signals reside in different frequency ranges. The first latent variables in these frequency ranges explain more than 95 pct of the variation in the stirring process for the entire single layer and the double layer data collected from the cold model. PLS analysis in these identified frequency ranges demonstrated that the latent

  4. Comparison of imaging characteristics between hepatic benign regenerative nodules and hepatocellular carcinomas associated with Budd-Chiari syndrome by contrast enhanced ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Ruifang, E-mail: zhangruifang999@hotmail.com [Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, 1 Eastern Jianshe Road, Zhengzhou, Henan Province 450052 (China); Qin, Shicheng, E-mail: qsc@zzu.edu.cn [Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, 1 Eastern Jianshe Road, Zhengzhou, Henan Province 450052 (China); Zhou, Yuanyuan, E-mail: yuanyuanzhou288@126.com [Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, 1 Eastern Jianshe Road, Zhengzhou, Henan Province 450052 (China); Song, Yi, E-mail: twinkle_song@126.com [Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, 1 Eastern Jianshe Road, Zhengzhou, Henan Province 450052 (China); Sun, Lulu, E-mail: sunluyytr@163.com [Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, 1 Eastern Jianshe Road, Zhengzhou, Henan Province 450052 (China)

    2012-11-15

    Purpose: To compare different imaging characteristics between hepatic benign regenerative nodules and hepatocellular carcinomas (HCCs) associated with Budd-Chiari syndrome (BCS) by contrast enhanced ultrasound (CEUS). Materials and methods: A total of 32 chronic BCS patients (mean age, 42 years; age range, 18-59 years) with hepatic nodules who underwent CEUS were retrospectively studied. All patients had no the history of viral hepatitis. There were 23 patients with benign regenerative nodules (22 {+-} 9 mm; range, 8-42 mm) and 9 patients with HCCs (63 {+-} 21 mm; range, 26-90 mm). Lesion characteristics, including number, size, vascularization on color Doppler flow imaging, echogenicity, peripheral hypoechoic rim, and enhancement patterns in arterial, portal, and late phases on CEUS, were analyzed. Results: There were significant differences in number and size of the lesions between two groups. No significant differences were observed in vascularity, echogenicity, and peripheral hypoechoic rim. Overall, there were significant differences in enhancement patterns in arterial, portal, and late phases between them on CEUS. Of 23 patients with benign regenerative nodules, 16 (70%) were center-to-periphery hyperenhanced and 7 patients (30%) were homogeneously hyperenhanced in arterial phase; the majority were homogeneously hyperenhanced in portal and late phases. Of 9 patients with HCCs, 8 (89%) were heterogeneously hyperenhanced in arterial phase and most of them were hypoenhanced in portal and late phases. Conclusion: CEUS imaging characteristics of benign regenerative nodules radically differ from that of HCCs in BCS patients.

  5. Analyzing Microarray Data.

    Science.gov (United States)

    Hung, Jui-Hung; Weng, Zhiping

    2017-03-01

    Because there is no widely used software for analyzing RNA-seq data that has a graphical user interface, this protocol provides an example of analyzing microarray data using Babelomics. This analysis entails performing quantile normalization and then detecting differentially expressed genes associated with the transgenesis of a human oncogene c-Myc in mice. Finally, hierarchical clustering is performed on the differentially expressed genes using the Cluster program, and the results are visualized using TreeView.

  6. Design of mechanical components for vibration reduction in an atomic force microscope.

    Science.gov (United States)

    Kim, Chulsoo; Jung, Jongkyu; Youm, Woosub; Park, Kyihwan

    2011-03-01

    Vibration is a key factor to be considered when designing the mechanical components of a high precision and high speed atomic force microscope (AFM). It is required to design the mechanical components so that they have resonant frequencies higher than the external and internal vibration frequencies. In this work, the mechanical vibration in a conventional AFM system is analyzed by considering its mechanical components, and a vibration reduction is then achieved by reconfiguring the mechanical components. To analyze the mechanical vibration, a schematic of the lumped model of the AFM system is derived and the vibrational influences of the AFM components are experimentally examined. Based on this vibration analysis, a reconfigured AFM system is proposed and its effects are compared to a conventional system through a series of simulations and experiments.

  7. Vibration Propagation in Spider Webs

    Science.gov (United States)

    Hatton, Ross; Otto, Andrew; Elias, Damian

    Due to their poor eyesight, spiders rely on web vibrations for situational awareness. Web-borne vibrations are used to determine the location of prey, predators, and potential mates. The influence of web geometry and composition on web vibrations is important for understanding spider's behavior and ecology. Past studies on web vibrations have experimentally measured the frequency response of web geometries by removing threads from existing webs. The full influence of web structure and tension distribution on vibration transmission; however, has not been addressed in prior work. We have constructed physical artificial webs and computer models to better understand the effect of web structure on vibration transmission. These models provide insight into the propagation of vibrations through the webs, the frequency response of the bare web, and the influence of the spider's mass and stiffness on the vibration transmission patterns. Funded by NSF-1504428.

  8. Aquaculture in bio-regenerative life support systems (BLSS): Considerations

    Science.gov (United States)

    Gonzales, John M.

    2009-04-01

    A significant amount of research has been invested into understanding the effects of including fish culture in bio-regenerative life support systems (BLSS) for long duration space habitation. While the benefits of fish culture as a sub-process for waste treatment and food production continue to be identified, other pressing issues arise that affect the overall equivalent system mass associated with fish culture in a BLSS. This paper is meant to provide insight into several issues affecting fish culture in a BLSS that will require attention in the future if fish meant for consumption are to be cultured in a BLSS.

  9. NASA Lewis Evaluation of Regenerative Fuel Cell (RFC) Systems

    Science.gov (United States)

    Hagedorn, N. H.; Gonzalez-Sanabria, O. D; Kohout, L. L.

    1986-01-01

    Evaluation of two regenerative fuel cell (RFC) systems was begun in-house, and under contracts and grants. The passive hydrogen-oxygen RFC offers the possibility of a high-energy density, long-life storage system for geosynchronous Earth orbit missions. The hydrogen-bromine RFC offers the combination of high efficiency and moderate energy density that could ideally suit low Earth orbit missions if successfully developed. Either or both of these systems would be attractive additions to the storage options available to designers of future missions.

  10. Analysing regenerative potential in zebrafish models of congenital muscular dystrophy.

    Science.gov (United States)

    Wood, A J; Currie, P D

    2014-11-01

    The congenital muscular dystrophies (CMDs) are a clinically and genetically heterogeneous group of muscle disorders. Clinically hypotonia is present from birth, with progressive muscle weakness and wasting through development. For the most part, CMDs can mechanistically be attributed to failure of basement membrane protein laminin-α2 sufficiently binding with correctly glycosylated α-dystroglycan. The majority of CMDs therefore arise as the result of either a deficiency of laminin-α2 (MDC1A) or hypoglycosylation of α-dystroglycan (dystroglycanopathy). Here we consider whether by filling a regenerative medicine niche, the zebrafish model can address the present challenge of delivering novel therapeutic solutions for CMD. In the first instance the readiness and appropriateness of the zebrafish as a model organism for pioneering regenerative medicine therapies in CMD is analysed, in particular for MDC1A and the dystroglycanopathies. Despite the recent rapid progress made in gene editing technology, these approaches have yet to yield any novel zebrafish models of CMD. Currently the most genetically relevant zebrafish models to the field of CMD, have all been created by N-ethyl-N-nitrosourea (ENU) mutagenesis. Once genetically relevant models have been established the zebrafish has several important facets for investigating the mechanistic cause of CMD, including rapid ex vivo development, optical transparency up to the larval stages of development and relative ease in creating transgenic reporter lines. Together, these tools are well suited for use in live-imaging studies such as in vivo modelling of muscle fibre detachment. Secondly, the zebrafish's contribution to progress in effective treatment of CMD was analysed. Two approaches were identified in which zebrafish could potentially contribute to effective therapies. The first hinges on the augmentation of functional redundancy within the system, such as upregulating alternative laminin chains in the candyfloss

  11. Revisiting the relationship between regenerative ability and aging

    Directory of Open Access Journals (Sweden)

    Seifert Ashley W

    2013-01-01

    Full Text Available Abstract Contrary to the longstanding view that newts (Notophthalamus viridescens, but not axolotls (Ambystoma mexicanum, can regenerate a lens, a recent report in BMC Biology by Panagiotis Tsonis and colleagues shows axolotls indeed possess this ability during early larval stages. In contrast, they show that zebrafish never posses this ability, even as embryos. This underscores the importance of comparing regenerative ability across species and reinforces the need to consider organ regeneration in the context of evolution, development, and aging. See research article: http://www.biomedcentral.com/1741-7007/10/103

  12. Nonhuman Primate Induced Pluripotent Stem Cells in Regenerative Medicine

    Directory of Open Access Journals (Sweden)

    Yuehong Wu

    2012-01-01

    Full Text Available Among the various species from which induced pluripotent stem cells have been derived, nonhuman primates (NHPs have a unique role as preclinical models. Their relatedness to humans and similar physiology, including central nervous system, make them ideal for translational studies. We review here the progress made in deriving and characterizing iPS cell lines from different NHP species. We focus on iPS cell lines from the marmoset, a small NHP in which several human disease states can be modeled. The marmoset can serve as a model for the implementation of patient-specific autologous cell therapy in regenerative medicine.

  13. Rebuilding a broken heart: lessons from developmental and regenerative biology.

    Science.gov (United States)

    Kuyumcu-Martinez, Muge N; Bressan, Michael C

    2016-11-01

    In May 2016, the annual Weinstein Cardiovascular Development and Regeneration Conference was held in Durham, North Carolina, USA. The meeting assembled leading investigators, junior scientists and trainees from around the world to discuss developmental and regenerative biological approaches to understanding the etiology of congenital heart defects and the repair of diseased cardiac tissue. In this Meeting Review, we present several of the major themes that were discussed throughout the meeting and highlight the depth and range of research currently being performed to uncover the causes of human cardiac diseases and develop potential therapies. © 2016. Published by The Company of Biologists Ltd.

  14. Stem cells: A potential regenerative future in dentistry

    Directory of Open Access Journals (Sweden)

    Sumit Narang

    2012-01-01

    Full Text Available In recent years, the field of dentistry has embossed its presence by taking major leaps in research and further bringing it into practice. The most valuable ongoing research in regenerative dentistry is the study on stem cells. It was instituted that stem cells grow rapidly and have the potential to form specialized dentin, bone, and neuronal cells. These neuronal cells can be used for dental therapies and can provide better treatment options for patients. The stem cells based therapies could help in new advances in treating damaged teeth, inducing bone regeneration and treating neural injury as well.

  15. Emerging nanotechnology approaches in tissue engineering and regenerative medicine

    OpenAIRE

    Kim ES; Ahn EH; Dvir T; Kim DH

    2014-01-01

    Eung-Sam Kim,1,2 Eun Hyun Ahn,3,4 Tal Dvir,5,6 Deok-Ho Kim1,4,71Department of Bioengineering, University of Washington, Seattle, WA, USA; 2Department of Biological Sciences, Chonnam National University, Gwangju, Korea; 3Department of Pathology, 4Institute of Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, USA; 5Department of Molecular Microbiology and Biotechnology, 6Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israe...

  16. A Possible Regenerative, Molten-Salt, Thermoelectric Fuel Cell

    Science.gov (United States)

    Greenberg, Jacob; Thaller, Lawrence H.; Weber, Donald E.

    1964-01-01

    Molten or fused salts have been evaluated as possible thermoelectric materials because of the relatively good values of their figures of merit, their chemical stability, their long liquid range, and their ability to operate in conjunction with a nuclear reactor to produce heat. In general, molten salts are electrolytic conductors; therefore, there will be a transport of materials and subsequent decomposition with the passage of an electric current. It is possible nonetheless to overcome this disadvantage by using the decomposition products of the molten-salt electrolyte in a fuel cell. The combination of a thermoelectric converter and a fuel cell would lead to a regenerative system that may be useful.

  17. Precision manufacturing for clinical-quality regenerative medicines.

    Science.gov (United States)

    Williams, David J; Thomas, Robert J; Hourd, Paul C; Chandra, Amit; Ratcliffe, Elizabeth; Liu, Yang; Rayment, Erin A; Archer, J Richard

    2012-08-28

    Innovations in engineering applied to healthcare make a significant difference to people's lives. Market growth is guaranteed by demographics. Regulation and requirements for good manufacturing practice-extreme levels of repeatability and reliability-demand high-precision process and measurement solutions. Emerging technologies using living biological materials add complexity. This paper presents some results of work demonstrating the precision automated manufacture of living materials, particularly the expansion of populations of human stem cells for therapeutic use as regenerative medicines. The paper also describes quality engineering techniques for precision process design and improvement, and identifies the requirements for manufacturing technology and measurement systems evolution for such therapies.

  18. Long life Regenerative Fuel Cell technology development plan

    Science.gov (United States)

    Littman, Franklin D.; Cataldo, Robert L.; Mcelroy, James F.; Stedman, Jay K.

    1992-01-01

    This paper summarizes a technology roadmap for completing advanced development of a Proton Exchange Membrane (PEM) Regenerative Fuel Cell (RFC) to meet long life (20,000 hrs at 50 percent duty cycle) mobile or portable power system applications on the surface of the moon and Mars. Development of two different sized RFC power system modules is included in this plan (3 and 7.5 kWe). A conservative approach was taken which includes the development of a Ground Engineering System, Qualification Unit, and Flight Unit. This paper includes a concept description, technology assessment, development issues, development tasks, and development schedule.

  19. Beam screen regenerative heating cryogenic impact and feasibility

    CERN Document Server

    Tavian, Laurent

    2003-01-01

    Desorbtion of gas (H2, CO, CO2...) trapped on the beam screen wall is envisaged by regenerative heating to temperature varying between 40 K and 90 K depending on the gas species. This new requirement has direct consequences on the cold mass heat loads, on the heating capacity needed to reach the regeneration conditions, as well as on the heater and piping configuration. This note presents different configuration schemes, studies the cryogenic feasibility with existing limitations and gives the impact on the cryogenic system in terms of additional equipment and corresponding extra costs.

  20. Modeling and analysis of the transient vibration of camshaft in multi-cylinder diesel engine

    OpenAIRE

    Jie Guo; Wenping Zhang; Xinyu Zhang

    2015-01-01

    The dynamics and vibrations of camshaft excited by multi-follower elements are modeled and analyzed. A pushrod valve train system from a four-cylinder diesel engine is selected as the case study. The camshaft is modeled to analyze the interactions of multi-follower elements. Both the camshaft angular vibration and bending vibration are taken into consideration. Each follower element is simplified as a multi-mass system. The lumped masses are connected by the spring elements and the damping el...

  1. Piezoelectric generator based on torsional modes for power harvesting from angular vibrations

    Institute of Scientific and Technical Information of China (English)

    CHEN Zi-guang; HU Yuan-tai; YANG Jia-shi

    2007-01-01

    Torsional vibration of a circular piezoelectric shell of polarized ceramics mounted on a rotationally vibrating base is analyzed. The shell is properly electroded and connected to a circuit such that an electric output is generated. The structure analyzed represents a piezoelectric generator for converting mechanical energy from angular vibrations to electrical energy. Analytical expressions and numerical results for the output voltage, current, power, efficiency and power density are given.

  2. Efficacy and safety of regenerative cell therapy for pulmonary arterial hypertension in animal models: a preclinical systematic review protocol.

    Science.gov (United States)

    Suen, Colin M; Zhai, Alex; Lalu, Manoj M; Welsh, Christopher; Levac, Brendan M; Fergusson, Dean; McIntyre, Lauralyn; Stewart, Duncan J

    2016-05-25

    Pulmonary arterial hypertension (PAH) is a rare disease (15 cases per million) that is characterized by widespread loss of the pulmonary microcirculation and elevated pulmonary vascular resistance leading to pathological right ventricular remodeling and ultimately right heart failure. Regenerative cell therapies (i.e., therapies involving cells with stem or progenitor-like properties) could potentially restore the effective lung microcirculation and provide a curative therapy for PAH. Preclinical evidence suggests that regenerative cell therapy using endothelial progenitor cells or mesenchymal stem cells may be beneficial in the treatment of PAH. These findings have led to the completion of a small number of human clinical trials, albeit with modest effect compared to animal studies. The objective of this systematic review is to compare the efficacy and safety of regenerative cell therapies in preclinical models of PAH as well as assess study quality to inform future clinical studies. We will include preclinical studies of PAH in which a regenerative cell type was administered and outcomes compared to a disease control. The primary outcome will be pulmonary hemodynamics as assessed by measurement of right ventricular systolic pressure and/or mean pulmonary arterial pressure. Secondary outcomes will include mortality, survival, right ventricular remodeling, pulmonary vascular resistance, cardiac output, cardiac index, pulmonary acceleration time, tricuspid annular systolic excursion, and right ventricular wall thickness. Electronic searches of MEDLINE and EMBASE databases will be constructed and reviewed by the Peer Review of Electronic Search Strategies (PRESS) process. Search results will be screened independently in duplicate. Data from eligible studies will be extracted, pooled, and analyzed using random effects models. Risk of bias will be assessed using the SYstematic Review Centre for Laboratory animal Experimentation (SYRCLE) risk of bias tool, and

  3. Frequency-Dependent Attenuation of Blasting Vibration Waves

    Science.gov (United States)

    Zhou, Junru; Lu, Wenbo; Yan, Peng; Chen, Ming; Wang, Gaohui

    2016-10-01

    The dominant frequency, in addition to the peak particle velocity, is a critical factor for assessing adverse effects of the blasting vibration on surrounding structures; however, it has not been fully considered in blasting design. Therefore, the dominant frequency-dependent attenuation mechanism of blast-induced vibration is investigated in the present research. Starting with blasting vibration induced by a spherical charge propagating in an infinite viscoelastic medium, a modified expression of the vibration amplitude spectrum was derived to reveal the frequency dependency of attenuation. Then, ground vibration induced by more complex and more commonly used cylindrical charge that propagates in a semi-infinite viscoelastic medium was analyzed by numerical simulation. Results demonstrate that the absorptive property of the medium results in the frequency attenuation versus distance, whereas a rapid drop or fluctuation occurs during the attenuation of ground vibration. Fluctuation usually appears at moderate to far field, and the dominant frequency generally decreases to half the original value when rapid drop occurs. The decay rate discrepancy between different frequency components and the multimodal structure of vibration spectrum lead to the unsmooth frequency-dependent attenuation. The above research is verified by two field experiments. Furthermore, according to frequency-based vibration standards, frequency drop and fluctuation should be considered when evaluating blast safety. An optimized piecewise assessment is proposed for more accurate evaluation: With the frequency drop point as the breakpoint, the assessment is divided into two independent sections along the propagating path.

  4. Evaluation of Bus Vibration Comfort Based on Passenger Crowdsourcing Mode

    Directory of Open Access Journals (Sweden)

    Hong Zhao

    2016-01-01

    Full Text Available Vibration comfort is an important factor affecting the quality of service (QoS of bus. In order to make people involved in supervising bus’s vibration comfort and improve passengers’ riding experience, a novel mode of passenger crowdsourcing is introduced. In this paper, comfort degree of bus vibration is calculated from bus’s vibration signals collected by passengers’ smartphones and sent through WiFi to the Boa web server which shows the vibration comfort on the LCD deployed in bus and maybe trigger alarm lamp when the vibration is beyond the threshold. Three challenges here have been overcome: firstly, space coordinate transformation algorithm is used to solve the constant drift of signals collected; secondly, a low-pass filter is designed to isolate gravity from signals real-timely via limited computing resources; thirdly, an embedded evaluation system is developed according to the calculation procedure specified by criterion ISO 2631-1997. Meanwhile, the model proposed is tested in a practical running environment, the vibration data in whole travel are recorded and analyzed offline. The results show that comfort degree of vibration obtained from the experimental system is identical with the truth, and this mode is proved to be effective.

  5. General principles of vibrational spectroscopies

    NARCIS (Netherlands)

    Weckhuysen, B.M.; Schoonheydt, R.A.

    2000-01-01

    Atoms in molecules and solids do not remain in fixed relative positions, but vibrate about some mean position. This vibrational motion is quantized and at room temperature, most of the molecules in a given sample are in their lowest vibrational state. Absorption of electromagnetic radiation with

  6. Vibration characteristics of ultrasonic complex vibration for hole machining

    Science.gov (United States)

    Asami, Takuya; Miura, Hikaru

    2012-05-01

    Complex vibration sources that use diagonal slits as a longitudinal-torsional vibration converter have been applied to ultrasonic motors, ultrasonic rock drilling, and ultrasonic welding. However, there are few examples of the application of these sources to ultrasonic machining in combination with an abrasive. Accordingly, a new method has been developed for machining of holes in brittle materials by using the ultrasonic longitudinal and torsional vibration of a hollow-type stepped horn with a diagonal slit vibration converter. In this paper, we compared vibration of a uniform rod and a hollow-type stepped horn, both with diagonal slits, when the conditions of the diagonal slits are constant.

  7. Vibration Sensitive Keystroke Analysis

    NARCIS (Netherlands)

    Lopatka, M.; Peetz, M.-H.; van Erp, M.; Stehouwer, H.; van Zaanen, M.

    2009-01-01

    We present a novel method for performing non-invasive biometric analysis on habitual keystroke patterns using a vibration-based feature space. With the increasing availability of 3-D accelerometer chips in laptop computers, conventional methods using time vectors may be augmented using a distinct fe

  8. Development of vibrating insoles

    NARCIS (Netherlands)

    Hijmans, J.M.; Geertzen, J.H.B.; Schokker, B.; Postema, K.

    2007-01-01

    The objective of this study was to describe the development of vibrating insoles. Insoles, providing a subsensory mechanical noise signal to the plantar side of the feet, may improve balance in healthy young and older people and in patients with stroke or diabetic neuropathy. This study describes th

  9. Total organic carbon analyzer

    Science.gov (United States)

    Godec, Richard G.; Kosenka, Paul P.; Smith, Brian D.; Hutte, Richard S.; Webb, Johanna V.; Sauer, Richard L.

    The development and testing of a breadboard version of a highly sensitive total-organic-carbon (TOC) analyzer are reported. Attention is given to the system components including the CO2 sensor, oxidation reactor, acidification module, and the sample-inlet system. Research is reported for an experimental reagentless oxidation reactor, and good results are reported for linearity, sensitivity, and selectivity in the CO2 sensor. The TOC analyzer is developed with gravity-independent components and is designed for minimal additions of chemical reagents. The reagentless oxidation reactor is based on electrolysis and UV photolysis and is shown to be potentially useful. The stability of the breadboard instrument is shown to be good on a day-to-day basis, and the analyzer is capable of 5 sample analyses per day for a period of about 80 days. The instrument can provide accurate TOC and TIC measurements over a concentration range of 20 ppb to 50 ppm C.

  10. The effects of vibration-reducing gloves on finger vibration.

    Science.gov (United States)

    Welcome, Daniel E; Dong, Ren G; Xu, Xueyan S; Warren, Christopher; McDowell, Thomas W

    2014-01-01

    Vibration-reducing (VR) gloves have been used to reduce the hand-transmitted vibration exposures from machines and powered hand tools but their effectiveness remains unclear, especially for finger protection. The objectives of this study are to determine whether VR gloves can attenuate the vibration transmitted to the fingers and to enhance the understanding of the mechanisms of how these gloves work. Seven adult male subjects participated in the experiment. The fixed factors evaluated include hand force (four levels), glove condition (gel-filled, air bladder, no gloves), and location of the finger vibration measurement. A 3-D laser vibrometer was used to measure the vibrations on the fingers with and without wearing a glove on a 3-D hand-arm vibration test system. This study finds that the effect of VR gloves on the finger vibration depends on not only the gloves but also their influence on the distribution of the finger contact stiffness and the grip effort. As a result, the gloves increase the vibration in the fingertip area but marginally reduce the vibration in the proximal area at some frequencies below 100 Hz. On average, the gloves reduce the vibration of the entire fingers by less than 3% at frequencies below 80 Hz but increase at frequencies from 80 to 400 Hz. At higher frequencies, the gel-filled glove is more effective at reducing the finger vibration than the air bladder-filled glove. The implications of these findings are discussed.

  11. Analyzing radioligand binding data.

    Science.gov (United States)

    Motulsky, Harvey; Neubig, Richard

    2002-08-01

    Radioligand binding experiments are easy to perform, and provide useful data in many fields. They can be used to study receptor regulation, discover new drugs by screening for compounds that compete with high affinity for radioligand binding to a particular receptor, investigate receptor localization in different organs or regions using autoradiography, categorize receptor subtypes, and probe mechanisms of receptor signaling, via measurements of agonist binding and its regulation by ions, nucleotides, and other allosteric modulators. This unit reviews the theory of receptor binding and explains how to analyze experimental data. Since binding data are usually best analyzed using nonlinear regression, this unit also explains the principles of curve fitting with nonlinear regression.

  12. Advances in hematology analyzers.

    Science.gov (United States)

    DeNicola, Dennis B

    2011-05-01

    The complete blood count is one of the basic building blocks of the minimum database in veterinary medicine. Over the past 20 years, there has been a tremendous advancement in the technology of hematology analyzers and their availability to the general practitioner. There are 4 basic methodologies that can be used to generate data for a complete blood count: manual methods, quantitative buffy coat analysis, automated impedance analysis, and flow cytometric analysis. This article will review the principles of these methodologies, discuss some of their advantages and disadvantages, and describe some of the hematology analyzers that are available for the in-house veterinary laboratory.

  13. Active vibration control of structures undergoing bending vibrations

    Science.gov (United States)

    Pla, Frederic G. (Inventor); Rajiyah, Harindra (Inventor)

    1995-01-01

    An active vibration control subassembly for a structure (such as a jet engine duct or a washing machine panel) undergoing bending vibrations caused by a source (such as the clothes agitator of the washing machine) independent of the subassembly. A piezoceramic actuator plate is vibratable by an applied electric AC signal. The plate is connected to the structure such that vibrations in the plate induced by the AC signal cause canceling bending vibrations in the structure and such that the plate is compressively pre-stressed along the structure when the structure is free of any bending vibrations. The compressive prestressing increases the amplitude of the canceling bending vibrations before the critical tensile stress level of the plate is reached. Preferably, a positive electric DC bias is also applied to the plate in its poling direction.

  14. Research on Effects of Blast Casting Vibration and Vibration Absorption of Presplitting Blasting in Open Cast Mine

    Directory of Open Access Journals (Sweden)

    Li Ma

    2016-01-01

    Full Text Available The impact energy produced by blast casting is able to break and cast rocks, yet the strong vibration effects caused at the same time would threaten the safety of mines. Based on the theory of Janbu’s Limit Equilibrium Method (LEM, pseudo-static method has been incorporated to analyze the influence of dynamic loads of blasting on slope stability. The horizontal loads produced by blast vibrations cause an increase in sliding forces, and this leads to a lower slope stability coefficient. When the tensile stresses of the two adjacent blast holes are greater than the tensile strength of rock mass, the radical oriented cracks are formed, which is the precondition for the formation of presplit face. Thus, the formula for calculating the blast hole spacing of presplit blasting can be obtained. Based on the analysis of the principles of vibration tester and vibration pick-up in detecting blast vibrations, a detection scheme of blast vibration is worked out by taking the blast area with precrack rear and non-precrack side of the detection object. The detection and research results of blast vibration show that presplit blasting can reduce the attenuation coefficient of stress wave by half, and the vibration absorption ratio could reach 50.2%; the impact of dynamic loads on the end-wall slope stability coefficient is 1.98%, which proves that presplit blasting plays an important role in shock absorption of blast casting.

  15. Methods to Analyze Bone Regenerative Response to Different rhBMP-2 Doses in Rabbit Craniofacial Defects

    Science.gov (United States)

    2014-02-28

    overnight and sterilized using ethylene oxide (EtO) (AN74i; Andersen Products, Haw River, NC) prior to rhBMP-2 loading. Sterility was verified using a...dose effects ranged between 6 and 8 for the imaging methods while histomorphometric analysis would require 25 animals per group to detect similar...supraphysiological doses of the protein. These high doses result in a high cost of therapy and po- tentially multiple adverse effects in clinical use

  16. Vibration Behaviour of Single Walled Carbon Nanotube using Finite Element

    Directory of Open Access Journals (Sweden)

    Ashirbad Swain

    2013-12-01

    Full Text Available The flexural vibration of single walled carbon nanotube has analyzed by finite element method. Timoshenko beam element formulation has been used for this purpose. Axial deformation has also been taken into account apart from shear deformation for formulation of the element. Results from multi-scale modeling for free vibration analysis have been found to be in good agreement with the literatures available. Effects of chirality and aspect ratio on vibration characteristics are presented. More over effect of initial axial strain or stress on natural frequency have been analysed and found to have significant effect on the natural frequency of the nanotube.

  17. Vibrating Liquefaction Experiment and Mechanism Study in Saturated Granular Media

    Institute of Scientific and Technical Information of China (English)

    Li Jianhua; Xu Ming; Ju Haiyan; Zhao Jiangqian; Huang Hongyuan; Sun Yezhi

    2006-01-01

    By the vibrating liquefaction experiment of tailings and fine-ores of iron, it is observed and noted that the change of pore water pressure when the vibrating liquefaction takes place. Based on relevant suppositions, the equation of wave propagation in saturated granular media is obtained. This paper postulates the potential vector equation and the velocity expression of three kinds of body waves under normal conditions.Utilizing the wave theory and the experimental results, the influence of three body waves on pore water pressure and granules has been analyzed in detail. This revealed the rapid increment mechanism of pore water pressure and the wave mechanism of vibrating liquefaction.

  18. Chatter Suppression with Ultrasonic Elliptical Vibration Based on Energy Principle

    Institute of Scientific and Technical Information of China (English)

    MA Chun-xiang; E Shamoto; T Moriwaki

    2005-01-01

    A new method is proposed to suppress chatter, in which the ultrasonic elliptical vibration is added on the cutting tool edge. It results in the fact that the rake face of tool is separated from the chip and the direction of the frictional force between the rake face and the chip is reversed in each cycle of elliptical vibration cutting. The experimental investigations show that the chatter can be suppressed effectively by adding ultrasonic elliptical vibration on the cutting tool edge. In order to make clear the reason of chatter suppression, the mechanism of chatter suppression is analyzed theoretically from the viewpoint of energy.

  19. Vibration velocity and frequency of underwater short-hole blasting

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Based on the measuring data of underwater blasting vibrationand the regression analysis results of these data, two formulae usually used of blasting vibration velocity were compared. Factors that canaffect blasting vibration and frequency were summarized and analyzed.It is thought that the effect of the number of freedom face and burden direction on blasting vibration should be considered during blastingdesign. Based on the relevant research results and the regression results of these data, a formula to calculate under water blasting frequency was put forward.

  20. Three-dimensional bioprinting in tissue engineering and regenerative medicine.

    Science.gov (United States)

    Gao, Guifang; Cui, Xiaofeng

    2016-02-01

    With the advances of stem cell research, development of intelligent biomaterials and three-dimensional biofabrication strategies, highly mimicked tissue or organs can be engineered. Among all the biofabrication approaches, bioprinting based on inkjet printing technology has the promises to deliver and create biomimicked tissue with high throughput, digital control, and the capacity of single cell manipulation. Therefore, this enabling technology has great potential in regenerative medicine and translational applications. The most current advances in organ and tissue bioprinting based on the thermal inkjet printing technology are described in this review, including vasculature, muscle, cartilage, and bone. In addition, the benign side effect of bioprinting to the printed mammalian cells can be utilized for gene or drug delivery, which can be achieved conveniently during precise cell placement for tissue construction. With layer-by-layer assembly, three-dimensional tissues with complex structures can be printed using converted medical images. Therefore, bioprinting based on thermal inkjet is so far the most optimal solution to engineer vascular system to the thick and complex tissues. Collectively, bioprinting has great potential and broad applications in tissue engineering and regenerative medicine. The future advances of bioprinting include the integration of different printing mechanisms to engineer biphasic or triphasic tissues with optimized scaffolds and further understanding of stem cell biology.

  1. PLATELET RICH FIBRIN: A PROMISING INNOVATION IN REGENERATIVE THERAPY

    Directory of Open Access Journals (Sweden)

    Arun

    2015-04-01

    Full Text Available Platelets can play a crucial role in regenerative therapy as they are reservoirs of growth factors and cytokines which are the key factors for regeneration of the bone and maturation of the soft tissue. Platelet - rich fibr in (PRF was first described by Choukroun et al. in France. It has been referred to as a second - generation platelet concentrate, which has been shown to have several advantages over traditionally prepared PRP. Platelet - rich fibrin (PRF is autologous plate let concentrates prepared from patient’s own blood. It is a natural fibrin - based biomaterial prepared from an anticoagulant - free blood harvest without any artificial biochemical modification that allows obtaining fibrin membranes enriched with platelets a nd growth factors. Evidence from the literature suggests the potential role of PRF in regeneration and tissue engineering. The slow polymerisation during centrifugation and fibrin - based structure makes PRF a better healing biomaterial than PRP and other fi brin adhesives. The purpose of this review article is to describe the novel second - generation platelet concentrate PRF, which is an improvement over the traditionally prepared PRP for use in regenerative dentistry.

  2. Bioluminescence regenerative cycle (BRC) system for nucleic acid quantification assays

    Science.gov (United States)

    Hassibi, Arjang; Lee, Thomas H.; Davis, Ronald W.; Pourmand, Nader

    2003-07-01

    A new label-free methodology for nucleic acid quantification has been developed where the number of pyrophosphate molecules (PPi) released during polymerization of the target nucleic acid is counted and correlated to DNA copy number. The technique uses the enzymatic complex of ATP-sulfurylase and firefly luciferase to generate photons from PPi. An enzymatic unity gain positive feedback is also implemented to regenerate the photon generation process and compensate any decay in light intensity by self regulation. Due to this positive feedback, the total number of photons generated by the bioluminescence regenerative cycle (BRC) can potentially be orders of magnitude higher than typical chemiluminescent processes. A system level kinetic model that incorporates the effects of contaminations and detector noise was used to show that the photon generation process is in fact steady and also proportional to the nucleic acid quantity. Here we show that BRC is capable of detecting quantities of DNA as low as 1 amol (10-18 mole) in 40μlit aqueous solutions, and this enzymatic assay has a controllable dynamic range of 5 orders of magnitude. The sensitivity of this technology, due to the excess number of photons generated by the regenerative cycle, is not constrained by detector performance, but rather by possible PPi or ATP (adenosine triphosphate) contamination, or background bioluminescence of the enzymatic complex.

  3. Promissory identities: Sociotechnical representations & innovation in regenerative medicine.

    Science.gov (United States)

    Gardner, John; Higham, Ruchi; Faulkner, Alex; Webster, Andrew

    2017-02-01

    The field of regenerative medicine (RM) is championed as a potential source of curative treatments and economic wealth, and initiatives have been launched in several countries to facilitate innovation within the field. As a way of examining the social dimensions of innovation within regenerative medicine, this paper explores the sociotechnical representations of RM technologies in the UK, and the tensions, affordances and complexities these representations present for actors within the field. Specifically, the paper uses the Science and Technology Studies-inspired notions of 'technology identity' and 'development space' to examine how particular technologies are framed and positioned by actors, and how these positionings subsequently shape innovation pathways. Four developing RM technologies are used as case studies: bioengineered tracheas; autologous chondrocyte implantation; T-cell therapies; and a 'point-of-care' cell preparation device. Using these case studies we argue that there are particular identity aspects that have powerful performative effects and provide momentum to innovation projects, and we argue that there are particular stakeholders in the UK RM landscape who appear to have considerable power in shaping these technology identities and thus innovation pathways.

  4. Amniotic fluid-derived stem cells in regenerative medicine research.

    Science.gov (United States)

    Joo, Sunyoung; Ko, In Kap; Atala, Anthony; Yoo, James J; Lee, Sang Jin

    2012-02-01

    The stem cells isolated from amniotic fluid present an exciting possible contribution to the field of regenerative medicine and amniotic fluid-derived stem (AFS) cells have significant potential for research and therapeutic applications. AFS cells are multipotent, showing the ability to differentiate into cell types from all three embryonic germ layers. They express both embryonic and adult stem cell markers, expand extensively without feeder cells, double in 36 h, and are not tumorigenic. The AFS cells can be maintained for over 250 population doublings and preserve their telomere length and a normal karyotype. They differentiate easily into specific cell lineages and do not require human embryo tissue for their isolation, thus avoiding the current controversies associated with the use of human embryonic stem (ES) cells. The discovery of the AFS cells has been recent, and a great deal of work remains to be performed on the characterization and use of these cells. This review describes the various differentiated lineages that AFS cells can form and the future of these promising new stem cells in regenerative medicine research.

  5. Implications of mesenchymal stem cells in regenerative medicine.

    Science.gov (United States)

    Kariminekoo, Saber; Movassaghpour, Aliakbar; Rahimzadeh, Amirbahman; Talebi, Mehdi; Shamsasenjan, Karim; Akbarzadeh, Abolfazl

    2016-05-01

    Mesenchymal stem cells (MSCs) are a population of multipotent progenitors which reside in bone marrow, fat, and some other tissues and can be isolated from various adult and fetal tissues. Self-renewal potential and multipotency are MSC's hallmarks. They have the capacity of proliferation and differentiation into a variety of cell lineages like osteoblasts, condrocytes, adipocytes, fibroblasts, cardiomyocytes. MSCs can be identified by expression of some surface molecules like CD73, CD90, CD105, and lack of hematopoietic specific markers including CD34, CD45, and HLA-DR. They are hopeful tools for regenerative medicine for repairing injured tissues. Many studies have focused on two significant features of MSC therapy: (I) systemically administered MSCs home to sites of ischemia or injury, and (II) MSCs can modulate T-cell-mediated immunological responses. MSCs express chemokine receptors and ligands involved in cells migration and homing process. MSCs induce immunomedulatory effects on the innate (dendritic cells, monocyte, natural killer cells, and neutrophils) and the adaptive immune system cells (T helper-1, cytotoxic T lymphocyte, and B lymphocyte) by secreting soluble factors like TGF-β, IL-10, IDO, PGE-2, sHLA-G5, or by cell-cell interaction. In this review, we discuss the main applications of mesenchymal stem in Regenerative Medicine and known mechanisms of homing and Immunomodulation of MSCs.

  6. Induced pluripotent stem cells and their implication for regenerative medicine.

    Science.gov (United States)

    Csobonyeiova, Maria; Polak, Stefan; Koller, Jan; Danisovic, Lubos

    2015-06-01

    In 2006 Yamanaka's group showed that stem cells with properties similar to embryonic stem cells could be generated from mouse fibroblasts by introducing four genes. These cells were termed induced pluripotent stem cells (iPSCs). Because iPSCs avoid many of ethical concerns associated with the use of embryonic material, they have great potential in cell-based regenerative medicine. They are suitable also for other various purposes, including disease modelling, personalized cell therapy, drug or toxicity screening and basic research. Moreover, in the future, there might become possible to generate organs for human transplantation. Despite these progresses, several studies have raised the concern for genetic and epigenetic abnormalities of iPSCs that could contribute to immunogenicity of some cells differentiated from iPSCs. Recent methodological improvements are increasing the ease and efficacy of reprogramming, and reducing the genomic modification. However, to minimize or eliminate genetic alternations in the derived iPSC line creation, factor-free human iPSCs are necessary. In this review we discuss recent possibilities of using iPSCs for clinical applications and new advances in field of their reprogramming methods. The main goal of present article was to review the current knowledge about iPSCs and to discuss their potential for regenerative medicine.

  7. Cardiovascular disease: primary prevention, disease modulation and regenerative therapy.

    LENUS (Irish Health Repository)

    Sultan, Sherif

    2012-10-01

    Cardiovascular primary prevention and regeneration programs are the contemporary frontiers in functional metabolic vascular medicine. This novel science perspective harnesses our inherent ability to modulate the interface between specialized gene receptors and bioavailable nutrients in what is labeled as the nutrient-gene interaction. By mimicking a natural process through the conveyance of highly absorbable receptor specific nutrients, it is feasible to accelerate cell repair and optimize mitochondrial function, thereby achieving cardiovascular cure. We performed a comprehensive review of PubMed, EMBASE and Cochrane Review databases for articles relating to cardiovascular regenerative medicine, nutrigenomics and primary prevention, with the aim of harmonizing their roles within contemporary clinical practice. We searched in particular for large-scale randomized controlled trials on contemporary cardiovascular pharmacotherapies and their specific adverse effects on metabolic pathways which feature prominently in cardiovascular regenerative programs, such as nitric oxide and glucose metabolism. Scientific research on \\'cardiovascular-free\\' centenarians delineated that low sugar and low insulin are consistent findings. As we age, our insulin level increases. Those who can decelerate the rapidity of this process are prompting their cardiovascular rejuvenation. It is beginning to dawn on some clinicians that contemporary treatments are not only failing to impact on our most prevalent diseases, but they may be causing more damage than good. Primary prevention programs are crucial elements for a better outcome. Cardiovascular primary prevention and regeneration programs have enhanced clinical efficacy and quality of life and complement our conventional endovascular practice.

  8. Johnson Space Center's Regenerative Life Support Systems Test Bed

    Science.gov (United States)

    Barta, D. J.; Henninger, D. L.

    1996-01-01

    The Regenerative Life Support Systems (RLSS) Test Bed at NASA's Johnson Space Center is an atmospherically closed, controlled environment facility for human testing of regenerative life support systems using higher plants in conjunction with physicochemical life support systems. The facility supports NASA's Advanced Life Support (ALS) Program. The facility is comprised of two large scale plant growth chambers, each with approximately 11 m^2 growing area. The root zone in each chamber is configurable for hydroponic or solid media plant culture systems. One of the two chambers, the Variable Pressure Growth Chamber (VPGC), is capable of operating at lower atmospheric pressures to evaluate a range of environments that may be used in a planetary surface habitat; the other chamber, the Ambient Pressure Growth Chamber (APGC) operates at ambient atmospheric pressure. The air lock of the VPGC is currently being outfitted for short duration (1 to 15 day) human habitation at ambient pressures. Testing with and without human subjects will focus on 1) integration of biological and physicochemical air and water revitalization systems; 2) effect of atmospheric pressure on system performance; 3) planetary resource utilization for ALS systems, in which solid substrates (simulated planetary soils or manufactured soils) are used in selected crop growth studies; 4) environmental microbiology and toxicology; 5) monitoring and control strategies; and 6) plant growth systems design. Included are descriptions of the overall design of the test facility, including discussions of the atmospheric conditioning, thermal control, lighting, and nutrient delivery systems.

  9. High Energy Density Regenerative Fuel Cell Systems for Terrestrial Applications

    Science.gov (United States)

    Burke, Kenneth A.

    1999-01-01

    Regenerative Fuel Cell System (RFCS) technology for energy storage has been a NASA power system concept for many years. Compared to battery-based energy storage systems, RFCS has received relatively little attention or resources for development because the energy density and electrical efficiency were not sufficiently attractive relative to advanced battery systems. Even today, RFCS remains at a very low technology readiness level (TRL of about 2 indicating feasibility has been demonstrated). Commercial development of the Proton Exchange Membrane (PEM) fuel cells for automobiles and other terrestrial applications and improvements in lightweight pressure vessel design to reduce weight and improve performance make possible a high energy density RFCS energy storage system. The results from this study of a lightweight RFCS energy storage system for a remotely piloted, solar-powered, high altitude aircraft indicate an energy density up to 790 w-h/kg with electrical efficiency of 53.4% is attainable. Such an energy storage system would allow a solar-powered aircraft to carry hundreds of kilograms of payload and remain in flight indefinitely for use in atmospheric research, earth observation, resource mapping. and telecommunications. Future developments in the areas of hydrogen and oxygen storage, pressure vessel design, higher temperature and higher- pressure fuel cell operation, unitized regenerative fuel cells, and commercial development of fuel cell technology will improve both the energy density and electrical efficiency of the RFCS.

  10. Stem cell biology and regenerative medicine for neonatal lung diseases.

    Science.gov (United States)

    Kang, Martin; Thébaud, Bernard

    2017-09-18

    Lung diseases remain one of the main causes of morbidity and mortality in neonates. Cell therapy and regenerative medicine have the potential to revolutionize the management of life-threatening and debilitating lung diseases that currently lack effective treatments. Over the past decade, the repair capabilities of stem/progenitor cells has been harnessed to prevent/rescue lung damage in experimental neonatal lung diseases. Mesenchymal stromal cells and amnion epithelial cells exert pleiotropic effects and represent ideal therapeutic cells for bronchopulmonary dysplasia, a multifactorial disease. Endothelial progenitor cells are optimally suited to promote lung vascular growth and attenuate pulmonary hypertension in infants with congenital diaphragmatic hernia or a vascular bronchopulmonary dysplasia phenotype. Induced pluripotent stem cells (iPSCs) are one of the most exciting breakthroughs of the past decade. Patient-specific iPSCs can be derived from somatic cells and differentiated into any cell type. iPSCs can be capitalized upon to develop personalized regenerative cell products for surfactant protein deficiencies-lethal lung disorders without treatment-that affect a single gene in a single cell type and thus lend themselves to phenotype-specific cell replacement. While the clinical translation has begun, more needs to be learned about the biology of these repair cells to make this translation successful.Pediatric Research accepted article preview online, 18 September 2017. doi:10.1038/pr.2017.232.

  11. The clinical use of regenerative therapy in COPD

    Directory of Open Access Journals (Sweden)

    Lipsi R

    2014-12-01

    Full Text Available Roberto Lipsi,1 Paola Rogliani,1 Luigino Calzetta,2 Andrea Segreti,1 Mario Cazzola1 1Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 2Department of Pulmonary Rehabilitation, San Raffaele Pisana Hospital, Istituti di Ricovero e Cura a Carattere Scientifico, Rome, Italy Abstract: Regenerative or stem cell therapy is an emerging field of treatment based on stimulation of endogenous resident stem cells or administration of exogenous stem cells to treat diseases or injury and to replace malfunctioning or damaged tissues. Current evidence suggests that in the lung, these cells may participate in tissue homeostasis and regeneration after injury. Animal and human studies have demonstrated that tissue-specific stem cells and bone marrow-derived cells contribute to lung tissue regeneration and protection, and thus administration of exogenous stem/progenitor cells or humoral factors responsible for the activation of endogenous stem/progenitor cells may be a potent next-generation therapy for chronic obstructive pulmonary disease. The use of bone marrow-derived stem cells could allow repairing and regenerate the damaged tissue present in chronic obstructive pulmonary disease by means of their engraftment into the lung. Another approach could be the stimulation of resident stem cells by means of humoral factors or photobiostimulation. Keywords: chronic obstructive pulmonary disease, stem cells, regenerative therapy, all-trans retinoic acid, photobiostimulation

  12. Regenerative Endodontic Procedures: A Perspective from Stem Cell Niche Biology.

    Science.gov (United States)

    Marí-Beffa, Manuel; Segura-Egea, Juan José; Díaz-Cuenca, Aránzazu

    2017-01-01

    Endodontics uses cell therapy strategies to treat pulpal and periapical diseases. During these therapies, surgeons aim to reconstruct the natural microenvironments that regulate the activity of dental stem cells. We searched for more than 400 articles in PubMed using key words from regenerative endodontics and dental stem cell biology. In 268 articles, we reviewed what factors may influence histologic results after preclinical dental treatments that use regenerative endodontic procedures after pulpectomy. Several factors, such as the origin of stem cells, the biomimicry of scaffolds used, and the size of lesions, are considered to influence the histologic appearance of the regenerated pulp-dentin complex after treatments. Information is accumulating on transcription factors that generate the pulp-dentin complex and survival/trophic factors that would benefit niche recovery and histologic results. In this article, we discuss the noninterchangeability of stem cells, the influence of dentin-entrapped molecule release on pulp regeneration and survival of stem cells, and the need of positional markers to assess treatments histologically. The ex vivo amplification of appropriate dental stem cells, the search for scaffolds storing the molecular diversity entrapped in the dentin, and the use of positional transcription factors as histologic markers are necessary to improve future preclinical experiments. Copyright © 2016 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  13. The hematopoietic system in the context of regenerative medicine.

    Science.gov (United States)

    Porada, Christopher D; Atala, Anthony J; Almeida-Porada, Graça

    2016-04-15

    Hematopoietic stem cells (HSC) represent the prototype stem cell within the body. Since their discovery, HSC have been the focus of intensive research, and have proven invaluable clinically to restore hematopoiesis following inadvertent radiation exposure and following radio/chemotherapy to eliminate hematologic tumors. While they were originally discovered in the bone marrow, HSC can also be isolated from umbilical cord blood and can be "mobilized" peripheral blood, making them readily available in relatively large quantities. While their ability to repopulate the entire hematopoietic system would already guarantee HSC a valuable place in regenerative medicine, the finding that hematopoietic chimerism can induce immunological tolerance to solid organs and correct autoimmune diseases has dramatically broadened their clinical utility. The demonstration that these cells, through a variety of mechanisms, can also promote repair/regeneration of non-hematopoietic tissues as diverse as liver, heart, and brain has further increased their clinical value. The goal of this review is to provide the reader with a brief glimpse into the remarkable potential HSC possess, and to highlight their tremendous value as therapeutics in regenerative medicine.

  14. Extracellular Matrix Scaffolds for Tissue Engineering and Regenerative Medicine.

    Science.gov (United States)

    Yi, Sheng; Ding, Fei; Gong, Leiiei; Gu, Xiaosong

    2017-01-01

    The extracellular matrix is produced by the resident cells in tissues and organs, and secreted into the surrounding medium to provide biophysical and biochemical support to the surrounding cells due to its content of diverse bioactive molecules. Recently, the extracellular matrix has been used as a promising approach for tissue engineering. Emerging studies demonstrate that extracellular matrix scaffolds are able to create a favorable regenerative microenvironment, promote tissue-specific remodeling, and act as an inductive template for the repair and functional reconstruction of skin, bone, nerve, heart, lung, liver, kidney, small intestine, and other organs. In the current review, we will provide a critical overview of the structure and function of various types of extracellular matrix, the construction of three-dimensional extracellular matrix scaffolds, and their tissue engineering applications, with a focus on translation of these novel tissue engineered products to the clinic. We will also present an outlook on future perspectives of the extracellular matrix in tissue engineering and regenerative medicine. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  15. Regenerative Medicine: Novel Approach in Burn Wound Healing

    Directory of Open Access Journals (Sweden)

    Zare

    2015-06-01

    Full Text Available Context Burn wounds of the skin require a long period to healing, which very often is incomplete, with functional and esthetic consequences for the patients. Stem cells in the traumatized tissue represent the promoters of the healing process and are a primary focus for regenerative medicine, which aims to find and use the triggers for the activation of stem cells of sin tissue. Evidence Acquisition At present, tissue engineering, composite epithelial autografts, multipotent stem cells and combined gene delivery with stem cell therapy are the approaches used in regenerative medicine. Alongside, the development of 3D scaffolds or matrices is a promising adjunct, as studies investigate the multiple uses of these supports for wound repair. Results Application of cells to the burn wound could be performed, either by the bedside, as a non-invasive procedure, or in the operating room, with the use of a matrix, scaffold or dermal substitute. Cell spraying, although under use in clinical setting, is not yet supported by conclusive data. Magnetic resonance imaging, optical imaging and positron emission tomography are currently used to assess the viability and location of stem cells, after transplantation. Conclusions Stem cell therapies in wound care may lessen the morbidities associated with wound healing. An ideal method for the effective administration of stem cells for burn patients has not yet been elucidated. Further comparison of the local and systemic effects in burn patients, associated with each route of stem cell delivery, needs to be performed.

  16. Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis

    Directory of Open Access Journals (Sweden)

    Michael G. Poulos

    2013-09-01

    Full Text Available The bone marrow (BM microenvironment is composed of multiple niche cells that, by producing paracrine factors, maintain and regenerate the hematopoietic stem cell (HSC pool (Morrison and Spradling, 2008. We have previously demonstrated that endothelial cells support the proper regeneration of the hematopoietic system following myeloablation (Butler et al., 2010; Hooper et al., 2009; Kobayashi et al., 2010. Here, we demonstrate that expression of the angiocrine factor Jagged-1, supplied by the BM vascular niche, regulates homeostatic and regenerative hematopoiesis through a Notch-dependent mechanism. Conditional deletion of Jagged-1 in endothelial cells (Jag1(ECKO mice results in a profound decrease in hematopoiesis and premature exhaustion of the adult HSC pool, whereas quantification and functional assays demonstrate that loss of Jagged-1 does not perturb vascular or mesenchymal compartments. Taken together, these data demonstrate that the instructive function of endothelial-specific Jagged-1 is required to support the self-renewal and regenerative capacity of HSCs in the adult BM vascular niche.

  17. Therapeutic Potential of Mesenchymal Stem Cells in Regenerative Medicine

    Directory of Open Access Journals (Sweden)

    Devang M. Patel

    2013-01-01

    Full Text Available Mesenchymal stem cells (MSCs are stromal cells that have the ability to self-renew and also exhibit multilineage differentiation into both mesenchymal and nonmesenchymal lineages. The intrinsic properties of these cells make them an attractive candidate for clinical applications. MSCs are of keen interest because they can be isolated from a small aspirate of bone marrow or adipose tissues and can be easily expanded in vitro. Moreover, their ability to modulate immune responses makes them an even more attractive candidate for regenerative medicine as allogeneic transplant of these cells is feasible without a substantial risk of immune rejection. MSCs secrete various immunomodulatory molecules which provide a regenerative microenvironment for a variety of injured tissues or organ to limit the damage and to increase self-regulated tissue regeneration. Autologous/allogeneic MSCs delivered via the bloodstream augment the titers of MSCs that are drawn to sites of tissue injury and can accelerate the tissue repair process. MSCs are currently being tested for their potential use in cell and gene therapy for a number of human debilitating diseases and genetic disorders. This paper summarizes the current clinical and nonclinical data for the use of MSCs in tissue repair and potential therapeutic role in various diseases.

  18. Johnson Space Center's Regenerative Life Support Systems Test Bed.

    Science.gov (United States)

    Barta, D J; Henninger, D L

    1996-01-01

    The Regenerative Life Support Systems (RLSS) Test Bed at NASA's Johnson Space Center is an atmospherically closed, controlled environment facility for human testing of regenerative life support systems using higher plants in conjunction with physicochemical life support systems. The facility supports NASA's Advanced Life Support (ALS) Program. The facility is comprised of two large scale plant growth chambers, each with approximately 11 m2 growing area. The root zone in each chamber is configurable for hydroponic or solid media plant culture systems. One of the two chambers, the Variable Pressure Growth Chamber (VPGC), is capable of operating at lower atmospheric pressures to evaluate a range of environments that may be used in a planetary surface habitat; the other chamber, the Ambient Pressure Growth Chamber (APGC) operates at ambient atmospheric pressure. The air lock of the VPGC is currently being outfitted for short duration (1 to 15 day) human habitation at ambient pressures. Testing with and without human subjects will focus on 1) integration of biological and physicochemical air and water revitalization systems; 2) effect of atmospheric pressure on system performance; 3) planetary resource utilization for ALS systems, in which solid substrates (simulated planetary soils or manufactured soils) are used in selected crop growth studies; 4) environmental microbiology and toxicology; 5) monitoring and control strategies; and 6) plant growth systems design. Included are descriptions of the overall design of the test facility, including discussions of the atmospheric conditioning, thermal control, lighting, and nutrient delivery systems.

  19. Intrinsic regenerative mechanisms of central nervous system neurons.

    Science.gov (United States)

    Muramatsu, Rieko; Ueno, Masaki; Yamashita, Toshihide

    2009-10-01

    Injuries to the adult central nervous system (CNS), such as spinal cord injury and brain contusion, can cause permanent functional deficits if axonal connections are broken. Spontaneous functional recovery rarely occurs. It has been widely accepted that the extracellular environment of the CNS inhibits neuronal regeneration. However, it should be noted that another reason for injured neurons failing to regenerate is their weak intrinsic ability to do so. The regeneration of injured neurons is a process involving many intracellular phenomena, including cytoskeletal changes, gene and protein expression, and changes in the responsiveness to extracellular cues. The capacity of injured neurons to regenerate is modulated to some extent by changes in the expression of intracellular signaling molecules such as glycogen synthase kinase-3beta and cyclic adenosine 3',5'-monophosphate. Knowledge of these effects has guided the development of animal models for regenerative therapies of CNS injury. Enhancing the intrinsic regenerative machinery of injured axons in the adult CNS is a potentially powerful strategy for treating patients with a CNS injury.

  20. Renal stem cell reprogramming: Prospects in regenerative medicine

    Institute of Scientific and Technical Information of China (English)

    Elvin; E; Morales; Rebecca; A; Wingert

    2014-01-01

    Stem cell therapy is a promising future enterprise for renal replacement in patients with acute and chronic kidney disease, conditions which affect millions worldwide and currently require patients to undergo lifelong medical treatments through dialysis and/or organ transplant. Reprogramming differentiated renal cells harvested from the patient back into a pluripotent state would decrease the risk of tissue rejection and provide a virtually unlimited supply of cells for regenerative medicine treatments, making it an exciting area of current research in nephrology. Among the major hurdles that need to be overcome before stem cell therapy for the kidney can be applied in a clinical setting are ensuring the fidelity and relative safety of the reprogrammed cells, as well as achieving feasible efficiency in the reprogramming processes that are utilized. Further, improved knowledge about the genetic control of renal lineage development is vital to identifying predictable and efficient reprogramming approaches, such as the expression of key modulators or the regulation of geneactivity through small molecule mimetics. Here, we discuss several recent advances in induced pluripotent stem cell technologies. We also explore strategies that have been successful in renal progenitor generation, and explore what these methods might mean for the development of cell-based regenerative therapies for kidney disease.

  1. Regenerative medicine: advances in new methods and technologies.

    Science.gov (United States)

    Park, Dong-Hyuk; Eve, David J

    2009-11-01

    The articles published in the journal Cell Transplantation - The Regenerative Medicine Journal over the last two years reveal the recent and future cutting-edge research in the fields of regenerative and transplantation medicine. 437 articles were published from 2007 to 2008, a 17% increase compared to the 373 articles in 2006-2007. Neuroscience was still the most common section in both the number of articles and the percentage of all manuscripts published. The increasing interest and rapid advance in bioengineering technology is highlighted by tissue engineering and bioartificial organs being ranked second again. For a similar reason, the methods and new technologies section increased significantly compared to the last period. Articles focusing on the transplantation of stem cell lineages encompassed almost 20% of all articles published. By contrast, the non-stem cell transplantation group which is made up primarily of islet cells, followed by biomaterials and fetal neural tissue, etc. comprised less than 15%. Transplantation of cells pre-treated with medicine or gene transfection to prolong graft survival or promote differentiation into the needed phenotype, was prevalent in the transplantation articles regardless of the kind of cells used. Meanwhile, the majority of non-transplantation-based articles were related to new devices for various purposes, characterization of unknown cells, medicines, cell preparation and/or optimization for transplantation (e.g. isolation and culture), and disease pathology.

  2. Design Analysis And Applications Of A Regenerative Bicycle Ergometer

    Directory of Open Access Journals (Sweden)

    Chukwuneke J. L.

    2015-08-01

    Full Text Available Man needs to do some form of physical work in other to remain healthy this work is similar to the work done by any machine or equipment and thus should be channeled to give useful output but rather it is usually dissipated into the environment in form of heat. The regenerative bicycle ergometer takes advantage of the greater power generated by the limbs and arms thus conserves converts and stores the energy dissipated by the rider with an ideal mechanical advantage of 7.6 it strategically uses simple mechanisms to magnify its work and then converts this mechanical energy into electrical energy by the use of a dynamo with a speed ratio of 108.5 and a transmission efficiency of 89 the rider pedals 27rpm to obtain the dynamos rated input of 2600rpm giving an output of 12.6volts. The regenerative bicycle ergometer is designed and constructed to perform all the core functions of a bicycle ergometer having an allowable load of 116.5kg and a maximum resistance of 65.33N which is equivalent to a mass of 6.66kg. The energy converted is stored in a 12volts battery making its use flexible clean and meeting the energy demands of man.

  3. Analyzing Stereotypes in Media.

    Science.gov (United States)

    Baker, Jackie

    1996-01-01

    A high school film teacher studied how students recognized messages in film, examining how film education could help students identify and analyze racial and gender stereotypes. Comparison of students' attitudes before and after the film course found that the course was successful in raising students' consciousness. (SM)

  4. Analyzing Workforce Education. Monograph.

    Science.gov (United States)

    Texas Community & Technical Coll. Workforce Education Consortium.

    This monograph examines the issue of task analysis as used in workplace literacy programs, debating the need for it and how to perform it in a rapidly changing environment. Based on experiences of community colleges in Texas, the report analyzes ways that task analysis can be done and how to implement work force education programs more quickly.…

  5. Lateral vibration behavior analysis and TLD vibration absorption design of the soft yoke single-point mooring system

    Science.gov (United States)

    Lyu, Bai-cheng; Wu, Wen-hua; Yao, Wei-an; Du, Yu

    2017-06-01

    Mooring system is the key equipment of FPSO safe operation. The soft yoke mooring system is regarded as one of the best shallow water mooring strategies and widely applied to the oil exploitation in the Bohai Bay in China and the Gulf of Mexico. Based on the analysis of numerous monitoring data obtained by the prototype monitoring system of one FPSO in the Bohai Bay, the on-site lateral vibration behaviors found on the site of the soft yoke subject to wave load were analyzed. ADAMS simulation and model experiment were utilized to analyze the soft yoke lateral vibration and it was determined that lateral vibration was resonance behaviors caused by wave excitation. On the basis of the soft yoke longitudinal restoring force being guaranteed, a TLD-based vibration damper system was constructed and the vibration reduction experiments with multi-tank space and multi-load conditions were developed. The experimental results demonstrated that the proposed TLD vibration reduction system can effectively reduce lateral vibration of soft yoke structures.

  6. GENERATOR VIBRATION FAULT DIAGNOSIS METHOD BASED ON ROTOR VIBRATION AND STATOR WINDING PARALLEL BRANCHES CIRCULATING CURRENT CHARACTERISTICS

    Institute of Scientific and Technical Information of China (English)

    Wan Shuting; Li Heming; Li Yonggang; Tang Guiji

    2005-01-01

    Rotor vibration characteristics are first analyzed, which are that the rotor vibration of fundamental frequency will increase due to rotor winding inter-turn short circuit fault, air-gap dynamic eccentricity fault, or imbalance fault, and the vibration of the second frequency will increase when the air-gap static eccentricity fault occurs. Next, the characteristics of the stator winding parallel branches circulating current are analyzed, which are that the second harmonics circulating current will increase when the rotor winding inter-turn short circuit fault occurs, and the fundamental circulating current will increase when the air-gap eccentricity fault occurs, neither being strongly affected by the imbalance fault. Considering the differences of the rotor vibration and circulating current characteristics caused by different rotor faults, a method of generator vibration fault diagnosis, based on rotor vibration and circulating current characteristics, is developed. Finally, the rotor vibration and circulating current of a type SDF-9 generator is measured in the laboratory to verify the theoretical analysis presented above.

  7. 汽车电动轮再生制动试验台的开发%Development of Automobile Electric Wheel Regenerative Braking Test Bench

    Institute of Scientific and Technical Information of China (English)

    徐奇; 贺萍; 韩承伟; 颜伏伍; 杜常青

    2015-01-01

    为研究轮毂电机驱动电动汽车再生制动的性能,基于DC/DC变换器和超级电容搭建了电动汽车再生制动系统,并设计开发了汽车电动轮再生制动试验台。对再生制动过程中制动力的调节进行理论分析,确立了通过调节DC/DC变换器输出电流的方法来调控再生制动力的控制方案。使用Matlab/Simulink对恒流再生制动过程进行建模仿真,并在试验台上进行再生制动实验,实验结果与仿真结果相吻合,表明所开发的电动轮再生制动试验台能实现制动能量回收的研究目标。%To study the regenerative braking performance of electric vehicle driven by hub motor , the electric vehicle regen-erative braking system based on DC/DC and super capacitor was constructed .And an automobile electric wheel regenerative bra-king test bench was designed and developed .The regenerative braking force adjustment during recovered braking was theoretically analyzed.The scheme of control regenerative braking force by the methods of adjusting the DC /DC output current was estab-lished.Using MATLAB/SIMULINK, the process of constant current recovery braking was simulated .And regenerative braking test was done on electric wheel comprehensive performance test bed .Through contrasting the simulation results and the experi-mental results, it can be found that the two trends are consistent with each other .The results show that the test bench can achieve the research goal of the braking energy recovery .

  8. Animal Communications Through Seismic Vibrations

    Energy Technology Data Exchange (ETDEWEB)

    Hill, Peggy (University of Tulsa)

    2001-05-02

    Substrate vibration has been important to animals as a channel of communication for millions of years, but our literature on vibration in this context of biologically relevant information is only decades old. The jaw mechanism of the earliest land vertebrates allowed them to perceive substrate vibrations as their heads lay on the ground long before airborne sounds could be heard. Although the exact mechanism of vibration production and the precise nature of the wave produced are not always understood, recent development of affordable instrumentation to detect and measure vibrations has allowed researchers to answer increasingly sophisticated questions about how animals send and receive vibration signals. We now know that vibration provides information used in predator defense, prey detection, recruitment to food, mate choice, intrasexual competition, and maternal/brood social interactions in a variety of insect orders, spiders, crabs, scorpions, chameleons, frogs, golden moles, mole rats, kangaroos rats, wallabies, elephants and bison.

  9. Maladie des vibrations

    Science.gov (United States)

    Shen, Shixin (Cindy); House, Ronald A.

    2017-01-01

    Résumé Objectif Permettre aux médecins de famille de comprendre l’épidémiologie, la pathogenèse, les symptômes, le diagnostic et la prise en charge de la maladie des vibrations, une maladie professionnelle importante et courante au Canada. Sources d’information Une recherche a été effectuée sur MEDLINE afin de relever les recherches et comptes rendus portant sur la maladie des vibrations. Une recherche a été effectuée sur Google dans le but d’obtenir la littérature grise qui convient au contexte canadien. D’autres références ont été tirées des articles relevés. Message principal La maladie des vibrations est une maladie professionnelle répandue touchant les travailleurs de diverses industries qui utilisent des outils vibrants. La maladie est cependant sous-diagnostiquée au Canada. Elle compte 3 éléments : vasculaire, sous la forme d’un phénomène de Raynaud secondaire; neurosensoriel; et musculosquelettique. Aux stades les plus avancés, la maladie des vibrations entraîne une invalidité importante et une piètre qualité de vie. Son diagnostic exige une anamnèse minutieuse, en particulier des antécédents professionnels, un examen physique, des analyses de laboratoire afin d’éliminer les autres diagnostics, et la recommandation en médecine du travail aux fins d’investigations plus poussées. La prise en charge consiste à réduire l’exposition aux vibrations, éviter les températures froides, abandonner le tabac et administrer des médicaments. Conclusion Pour assurer un diagnostic rapide de la maladie des vibrations et améliorer le pronostic et la qualité de vie, les médecins de famille devraient connaître cette maladie professionnelle courante, et pouvoir obtenir les détails pertinents durant l’anamnèse, recommander les patients aux cliniques de médecine du travail et débuter les demandes d’indemnisation de manière appropriée. PMID:28292812

  10. Note: Vibration suppression using tunable vibration absorber based on stiffness variable magneto-rheological gel

    Science.gov (United States)

    Shin, Beom-Cheol; Yoon, Jung-Hwan; Kim, Young-Keun; Kim, Kyung-Soo

    2015-10-01

    This paper proposes a novel adaptive tunable vibration absorber (TVA) based on a smart material the magnetorheological gel (MRG) to achieve a wide range of tonal vibration suppression on the primary system to protect any connected sensitive device. The vibration suppression performance of the MRG TVA was analyzed by conducting a modal test of the primary system under different magnetic fields. The experiment verified that the proposed MRG TVA can be controlled to produce 379% of stiffness change or 115% of tuning frequency under just 200 mT magnetic field. The proposed MRG TVA was found to possess a wider tuning frequency range than the TVA based on other smart material such as magnetorheological elastomer.

  11. 78 FR 43889 - Synergizing Efforts in Standards Development for Cellular Therapies and Regenerative Medicine...

    Science.gov (United States)

    2013-07-22

    ... Therapies and Regenerative Medicine Products; Public Workshop AGENCY: Food and Drug Administration, HHS... Development for Cellular Therapies and Regenerative Medicine Products.'' The purpose of the public workshop is to bring together a broad range of stakeholders to discuss current and future standards...

  12. Adaptation and validation of the REGEN expert system for the Central Appalachians

    Science.gov (United States)

    Lance A. Vickers; Thomas R. Fox; David L. Loftis; David A. Boucugnani

    2011-01-01

    REGEN is an expert system that predicts future species composition at the onset of stem exclusion using preharvest stand conditions. To extend coverage into hardwood stands of the Central Appalachians, we developed REGEN knowledge bases for four site qualities (xeric, subxeric, submesic, mesic) based on relevant literature and expert opinion. Data were collected from...

  13. Predicting Forest Regeneration in the Central Appalachians Using the REGEN Expert System

    Science.gov (United States)

    Lance A. Vickers; Thomas R. Fox; David L. Loftis; David A. Boucugnani

    2011-01-01

    REGEN is an expert system designed by David Loftis to predict the future species composition of dominant and codominant stems in forest stands at the onset of stem exclusion following a proposed harvest. REGEN predictions are generated using competitive rankings for advance reproduction along with other existing stand conditions. These parameters are contained within...

  14. Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine

    NARCIS (Netherlands)

    Harink, M.B.M.; Gac, le S.; Truckenmüller, R.K.; Blitterswijk, van C.A.; Habibovic, P.

    2013-01-01

    The aim of regenerative medicine is to restore or establish normal function of damaged tissues or organs. Tremendous efforts are placed into development of novel regenerative strategies, involving (stem) cells, soluble factors, biomaterials or combinations thereof, as a result of the growing need ca

  15. Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine

    NARCIS (Netherlands)

    Harink, Björn; le Gac, Severine; Truckenmüller, R.K.; van Blitterswijk, Clemens; Habibovic, Pamela

    2013-01-01

    The aim of regenerative medicine is to restore or establish normal function of damaged tissues or organs. Tremendous efforts are placed into development of novel regenerative strategies, involving (stem) cells, soluble factors, biomaterials or combinations thereof, as a result of the growing need

  16. Vehicle state estimator based regenerative braking implementation on an electric vehicle to improve lateral vehicle stability

    NARCIS (Netherlands)

    Jansen, S.T.H.; Boekel, J.J.P. van; Iersel, S.S. van; Besselink, I.J.M.; Nijmeijer, H.

    2013-01-01

    The driving range of electric vehicles can be extended using regenerative braking. Regenerative braking uses the elctric drive system, and therefore only the driven wheels, for decelerating the vehicle. Braking on one axle affects the stability of the vehicle, especially for road conditions with

  17. PhosphoSiteAnalyzer

    DEFF Research Database (Denmark)

    Bennetzen, Martin V; Cox, Jürgen; Mann, Matthias

    2012-01-01

    an algorithm to retrieve kinase predictions from the public NetworKIN webpage in a semiautomated way and applies hereafter advanced statistics to facilitate a user-tailored in-depth analysis of the phosphoproteomic data sets. The interface of the software provides a high degree of analytical flexibility...... and is designed to be intuitive for most users. PhosphoSiteAnalyzer is a freeware program available at http://phosphosite.sourceforge.net ....

  18. Magnetoresistive emulsion analyzer.

    Science.gov (United States)

    Lin, Gungun; Baraban, Larysa; Han, Luyang; Karnaushenko, Daniil; Makarov, Denys; Cuniberti, Gianaurelio; Schmidt, Oliver G

    2013-01-01

    We realize a magnetoresistive emulsion analyzer capable of detection, multiparametric analysis and sorting of ferrofluid-containing nanoliter-droplets. The operation of the device in a cytometric mode provides high throughput and quantitative information about the dimensions and magnetic content of the emulsion. Our method offers important complementarity to conventional optical approaches involving ferrofluids, and paves the way to the development of novel compact tools for diagnostics and nanomedicine including drug design and screening.

  19. Collisional deactivation of highly vibrationally excited pyrazine

    Science.gov (United States)

    Miller, Laurie A.; Barker, John R.

    1996-07-01

    The collisional deactivation of vibrationally excited pyrazine (C4N2H4) in the electronic ground state by 19 collider gases was studied using the time-resolved infrared fluorescence (IRF) technique. The pyrazine was photoexcited with a 308 nm laser and its vibrational deactivation was monitored following rapid radiationless transitions to produce vibrationally excited molecules in the electronic ground state. The IRF data were analyzed by a simple approximate inversion method, as well as with full collisional master equation simulations. The average energies transferred in deactivating collisions (d) exhibit a near-linear dependence on vibrational energy at lower energies and less dependence at higher energies. The deactivation of ground state pyrazine was found to be similar to that of ground state benzene [J. R. Barker and B. M. Toselli, Int. Rev. Phys. Chem. 12, 305 (1990)], but it is strikingly different from the deactivation of triplet state pyrazine [T. J. Bevilacqua and R. B. Weisman, J. Chem. Phys. 98, 6316 (1993)].

  20. IPv6 Protocol Analyzer

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    With the emerging of next generation Intemet protocol (IPv6), it is expected to replace the current version of Internet protocol (IPv4) that will be exhausted in the near future. Besides providing adequate address space, some other new features are included into the new 128 bits of IP such as IP auto configuration, quality of service, simple routing capability, security, mobility and multicasting. The current protocol analyzer will not be able to handle IPv6 packets. This paper will focus on developing protocol analyzer that decodes IPv6 packet. IPv6 protocol analyzer is an application module,which is able to decode the IPv6 packet and provide detail breakdown of the construction of the packet. It has to understand the detail construction of the IPv6, and provide a high level abstraction of bits and bytes of the IPv6 packet.Thus it increases network administrators' understanding of a network protocol,helps he/she in solving protocol related problem in a IPv6 network environment.

  1. MRI tracking of SPIO labelled stem cells in a true regenerative environment, the regenerating limb of the axolotl

    DEFF Research Database (Denmark)

    Lauridsen, Henrik; Foldager, Casper Bindzus; Hagensen, Mette

    are generally restricted by their limited regenerative potential. Conversely, excellent animal models for regenerative studies exist in lower vertebrates such as the urodele amphibians (salamanders and newts), exemplified in the iconic Mexican axolotl (Ambystoma mexicanum) capable of regenerating whole limbs...

  2. Regenerative cell therapy and pharmacotherapeutic intervention in heart failure Part 2 : Pharmacological targets, agents and intervention perspectives

    NARCIS (Netherlands)

    Qian, C.; Schoemaker, R. G.; van Gilst, W. H.; Yu, B.; Roks, A. J. M.

    2008-01-01

    Regenerative medicine represents a promising perspective on therapeutic angiogenesis in patients with cardiovascular disease, including heart failure. However, previous or ongoing clinical trials show ambiguous outcomes with respect to the benefit of regenerative therapy by means of bone marrow stem

  3. Regenerative cell therapy and pharmacotherapeutic intervention in heart failure Part 2 : Pharmacological targets, agents and intervention perspectives

    NARCIS (Netherlands)

    Qian, C.; Schoemaker, R. G.; van Gilst, W. H.; Yu, B.; Roks, A. J. M.

    2008-01-01

    Regenerative medicine represents a promising perspective on therapeutic angiogenesis in patients with cardiovascular disease, including heart failure. However, previous or ongoing clinical trials show ambiguous outcomes with respect to the benefit of regenerative therapy by means of bone marrow stem

  4. Engineering model system study for a regenerative fuel cell: Study report

    Science.gov (United States)

    Chang, B. J.; Schubert, F. H.; Kovach, A. J.; Wynveen, R. A.

    1984-01-01

    Key design issues of the regenerative fuel cell system concept were studied and a design definition of an alkaline electrolyte based engineering model system or low Earth orbit missions was completed. Definition of key design issues for a regenerative fuel cell system include gaseous reactant storage, shared heat exchangers and high pressure pumps. A power flow diagram for the 75 kW initial space station and the impact of different regenerative fuel cell modular sizes on the total 5 year to orbit weight and volume are determined. System characteristics, an isometric drawing, component sizes and mass and energy balances are determined for the 10 kW engineering model system. An open loop regenerative fuel cell concept is considered for integration of the energy storage system with the life support system of the space station. Technical problems and their solutions, pacing technologies and required developments and demonstrations for the regenerative fuel cell system are defined.

  5. Hydroelastic Vibrations of Ships

    DEFF Research Database (Denmark)

    Jensen, Jørgen Juncher; Folsø, Rasmus

    2002-01-01

    A formula for the necessary hull girder bending stiffness required to avoid serious springing vibrations is derived. The expression takes into account the zero crossing period of the waves, the ship speed and main dimensions. For whipping vibrations the probability of exceedance for the combined...... wave- and whipping induced bending moment is derived under the assumption that the maximum peak value in a whipping sequence occurs simultaneously with a peak in sagging wave-induced bending moment, but that the magnitudes of these two peaks are statistically independent. The expression can be written...... as the usual Rayleigh distribution for the wave response multiplied by a factor independent of the significant wave height. Finally, the springing and whipping predictions are compared with model test results....

  6. Laser induced structural vibration

    Science.gov (United States)

    Koss, L. L.; Tobin, R. C.

    1983-01-01

    A technique is described for exciting structural vibration by using a focussed laser beam to vaporize material from a target attached to the structure. The rapid ejection of material results in an impulsive reaction to the target which is transmitted to the structure. The method has been studied with a Nd: glass laser, operated in the long pulse mode, in combination with a bismuth target attached in turn to a ballistic pendulum and cantilever beam. The specific mechanical energy was found to be proportional to the laser pulse energy raised to a power in the range 2.5-2.9. The highest efficiency of energy transfer achieved for the first vibrational mode of the cantilever was about 2 millipercent for the maximum laser pulse energy used, 1.5 J, the signal to noise ratio then being about 40 dB.

  7. Articular cartilage repair and the evolving role of regenerative medicine

    Directory of Open Access Journals (Sweden)

    Pieter K Bos

    2010-10-01

    Full Text Available Pieter K Bos1, Marloes L van Melle1, Gerjo JVM van Osch1,21Department of Orthopaedic Surgery, Erasmus MC, Rotterdam, the Netherlands; 2Department of Otorhinolaryngology, Erasmus MC, Rotterdam, the NetherlandsAbstract: Among the growing applications of regenerative medicine, clinical articular cartilage repair has now been used for 2 decades and forms a successful example of translational medicine. Cartilage is characterized by a limited intrinsic repair capacity following injury. Articular cartilage defects cause symptoms, are not spontaneously repaired, and are generally believed to result in early osteoarthritis. Marrow stimulation techniques, osteochondral transplantation, and cell-based therapies, such as autologous chondrocyte implantation (ACI and use of mesenchymal stem cells (MSCs, are used for tissue regeneration, symptom relief, and prevention of further joint degeneration. The exact incidence of cartilage defects and the natural outcome of joints with these lesions are unclear. Currently available cartilage repair techniques are designed for defect treatment in otherwise healthy joints and limbs, mostly in young adults. The natural history studies presented in this review estimated that the prevalence of cartilage lesions in this patient group ranges from 5% to 11%. The background and results from currently available randomized clinical trials of the three mostly used cartilage repair techniques are outlined in this review. Osteochondral transplantation, marrow stimulation, and ACI show improvement of symptoms with an advantage for cell-based techniques, but only a suggestion that risk for joint degeneration can be reduced. MSCs, characterized by their good proliferative capacity and the potential to differentiate into different mesenchymal lineages, form an attractive alternative cell source for cartilage regeneration. Moreover, MSCs provide a regenerative microenvironment by the secretion of bioactive factors. This trophic activity

  8. ``HYTEC''—A thermally regenerative fuel cell

    Science.gov (United States)

    Roy, Prodyot; Salamah, Samir A.; Maldonado, Jerry; Narkiewicz, Regina S.

    1993-01-01

    HYTEC (Hydrogen Thermo-Electrochemical Converter) is a thermally regenerative fuel cell for direct conversion of heat into electricity. The principles of basic cell operation involve ionic transport of hydrogen through a hydride-ion (H-) conducting, molten electrolyte, and reaction with alkali metals, oxygen, or air. In order to operate HYTEC in a thermally regenerative mode, pure Li and Na, or a mixture of Li/Na alloy, is used for reaction with hydrogen, to form metal hydride which is subsequently decomposed to metal and hydrogen at higher temperatures. The reactants are then separated and redirected to the electrochemical cell. In the cell the molten, H--conducting electrolyte is immobilized between two thin hydrogen-permeable, solid, metallic electrodes which also act as current collectors. The H2 gas first diffuses through the cathode electrode and forms a hydride ion (H+e→H-) at the cathode-electrolyte interface. The H- ion subsequently migrated through the electrolyte under a chemical potential gradient created by the presence of the alkali metal in the anode chamber. The H- ion releases the electron to form hydrogen atoms (H-→H+e) at the anode-electrolyte interface. The hydrogen atom diffuses through the anode electrode and reacts with the alkali metal to form metal hydride. The electron released passes through the load circuit to complete the cycle. In the regeneration scheme, the fuel cell is operated at temperature T1. The metal hydride formed at the anode is pumped to the decomposition chamber through a recuperator. The metal hydride is decomposed at a higher temperature, T2, by an external heat source. The H2 gas is separated from the alkali metal by a H2-permeable, solid, metallic membrane and fed into the anode chamber of the cell. The hydrogen-depleted alkali metal is directed to the cathode chamber of the cell, via the recuperator, to complete the cycle. To date, electrochemical feasibility of the concept has been experimentally demonstrated. A

  9. Nanotechnology-based approaches for regenerative medicine and biosensing

    Science.gov (United States)

    Solanki, Aniruddh P.

    The recent emergence of nanotechnology has set high expectations in many fields of science, especially in biology and medicine. Nanotechnology-based approaches are expected to solve key questions in the emerging field of regenerative medicine. Regenerative medicine essentially deals with regeneration of cells, ultimately leading to the formation of tissues and organs. For this purpose, stem cells, embryonic stem cells or adult stem cells, are thought to be ideal resources. However, many challenges need to be addressed before the full therapeutic potential of stem cells can be harnessed. Controlling the differentiation of stem cells into cells of a specific lineage is extremely vital and challenging. Addressing this challenge, in this work, novel nanotechnology-based approaches for controlling the differentiation of neural stem cells (NSCs) into neurons has been presented. Regeneration of damaged neurons, due to traumatic injuries or degenerative diseases, is extremely challenging. For this purpose, NSCs can be used as resources that can differentiate into neurons, thus having great potential in solving needs of many patients suffering from such conditions. For controlling the differentiation of stem cells, soluble cues (comprising of small molecules and biomolecules) and insoluble cues (cell-cell interactions and cell-microenvironment interactions) play a very important role. The delivery of soluble cues, such as genetic material, into stem cells is extremely challenging. The initial part of this work presents the use of nanomaterials for efficiently delivering soluble cues such as small molecules and small interfering RNA (siRNA) into NSCs for controlling their differentiation into neurons. However, for regenerative purposes, it is preferred that least amounts of the delivery vehicle be used. Thus, the following part of the thesis presents the development and applications of nanotechnology-based approaches for enhancing the differentiation of NSCs into neurons

  10. An In Vitro Assay to Study Induction of the Regenerative State in Sensory Neurons

    Science.gov (United States)

    Frey, E.; Valakh, V.; Karney-Grobe, S.; Shi, Y.; Milbrandt, J.; DiAntonio, A.

    2014-01-01

    After injury, peripheral neurons activate a pro-regenerative program that facilitates axon regeneration. While many regeneration-associated genes have been identified, the mechanism by which injury activates this program is less well understood. Furthermore, identifying pharmacological methods to induce a pro-regenerative state could lead to novel treatments to repair the injured nervous system. Therefore, we have developed an in vitro assay to study induction of the pro-regenerative state following injury or pharmacological treatment. First, we took advantage of the observation that dissociating and culturing sensory neurons from dorsal root ganglia activates a pro-regenerative program. We show that cultured neurons activate transcription factors and upregulate regeneration-associated genes common to the pro-regenerative program within the first hours after dissection. In a paradigm similar to pre-conditioning, neurons injured by dissociation display enhanced neurite outgrowth when replated as early as 12 hours after being removed from the animal. Furthermore, stimulation of the pro-regenerative state improves growth on inhibitory substrates and requires DLK/JNK signaling, both hallmarks of the pro-regeneration response in vivo. Finally, we modified this assay in order to identify new methods to activate the pro-regenerative state in an effort to mimic the pre-conditioning effect. We report that after several days in culture, neurons down-regulate many molecular hallmarks of injury and no longer display enhanced neurite outgrowth after replating. Hence, these neurons are functionally naïve and are a useful tool for identifying methods to induce the pro-regenerative state. We show that both injury and pre-treatment with forskolin reactivate the pro-regenerative state in this paradigm. Hence, this assay is useful for identifying pharmacological agents that induce the pro-regenerative state in the absence of injury. PMID:25447942

  11. SOME PROBLEMS CONCERNING FREE NON-LINEAR VIBRATIONS OF BEAM STRUCTURES

    Directory of Open Access Journals (Sweden)

    S. V. Bosakov

    2008-01-01

    Full Text Available The paper analyzes an influence of physical non-linearity material account on vibrations of single beams with various support fixing. The authors also analyze power criteria for existing stable periodic vibrations and dependence of vibration period on initial power is determined in the paper. Accurate values of an amplitude and non-linear bending vibration period of beams have been also determined as a conservative system with due account of initial conditions. A number of examples are given that clearly illustrate the obtained solutions and show an influence rate of the mentioned effects on amplitude-frequency characteristics of non-linear systems. 

  12. Analyzing Chinese Financial Reporting

    Institute of Scientific and Technical Information of China (English)

    SABRINA; ZHANG

    2008-01-01

    If the world’s capital markets could use a harmonized accounting framework it would not be necessary for a comparison between two or more sets of accounting standards. However,there is much to do before this becomes reality.This article aims to pres- ent a general overview of China’s General Accepted Accounting Principles(GAAP), U.S.General Accepted Accounting Principles and International Financial Reporting Standards(IFRS),and to analyze the differ- ences among IFRS,U.S.GAAP and China GAAP using fixed assets as an example.

  13. Mineral/Water Analyzer

    Science.gov (United States)

    1983-01-01

    An x-ray fluorescence spectrometer developed for the Viking Landers by Martin Marietta was modified for geological exploration, water quality monitoring, and aircraft engine maintenance. The aerospace system was highly miniaturized and used very little power. It irradiates the sample causing it to emit x-rays at various energies, then measures the energy levels for sample composition analysis. It was used in oceanographic applications and modified to identify element concentrations in ore samples, on site. The instrument can also analyze the chemical content of water, and detect the sudden development of excessive engine wear.

  14. Vibration Induced Microfluidic Atomization

    Science.gov (United States)

    Yeo, Leslie; Qi, Aisha; Friend, James

    2008-11-01

    We demonstrate rapid generation of micron aerosol droplets in a microfluidic device in which a fluid drop is exposed to surface vibration as it sits atop a piezoelectric substrate. Little, however, is understood about the processes by which these droplets form due to the complex hydrodynamic processes that occur across widely varying length and time scales. Through experiments, scaling theory and numerical modelling, we elucidate the interfacial destabilization mechanisms that lead to droplet formation. Droplets form due to the axisymmetric break-up of cylindrical liquid jets ejected as a consequence of interfacial destabilization. Their 10 μm size correlates with the jet radius and the instability wavelength, both determined from a viscous-capillary dominant force balance and confirmed through a numerical solution. With the exception of drops that spread into thin films with thicknesses on the order of the boundary layer dimension, the free surface is always observed to vibrate at the capillary-viscous resonance frequency despite the surface vibration frequency being several orders larger. This is contrary to common assumptions used in deriving subharmonic models resulting in a Mathieu equation, which has commonly led to spurious predictions in the droplet size.

  15. Pickin’ up good vibrations

    CERN Multimedia

    Katarina Anthony

    2015-01-01

    In preparation for the civil engineering work on the HL-LHC, vibration measurements were carried out at the LHC’s Point 1 last month. These measurements will help evaluate how civil engineering work could impact the beam, and will provide crucial details about the site’s geological make-up before construction begins.   A seismic truck at Point 1 generated wave-like vibrations measured by EN/MME. From carrying out R&D to produce state-of-the-art magnets to developing innovative, robust materials capable of withstanding beam impact, the HL-LHC is a multi-faceted project involving many groups and teams across CERN’s departments. It was in this framework that the project management mandated CERN's Mechanical and Materials Engineering (EN/MME) group to measure the propagation of vibrations around Point 1. Their question: can civil engineering work for the HL-LHC – the bulk of which is scheduled for LS2 – begin while the LHC is running? Alth...

  16. A Study on the Construction Plan for Vibration Analysis System of HANARO Rotating Machinery

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Jeong Soo; Yoon, Doo Byung; Lee, Jung Hee; Jung, Hoan Sung

    2005-10-15

    The objective of this study is to establish a construction plan for vibration analysis system of HANARO's rotating machinery. To achieve this purpose, as a first step, the references related to the vibration analysis system for the rotating machinery were investigated. In addition, to verify the possibility of condition monitoring of the pumps, vibration signals obtained from the vibration monitoring system were analyzed. The results show that using the accelerometers mounted on the bearing locations of the pumps can monitor the current status of the pump such as unbalance, misalignment, and bearing condition. Based on the results of this study, the construction plans for the vibration analysis system of HANARO have been established. The hardware of the vibration analysis system will be installed by the end of this year. It is expected that the developed vibration analysis system can be utilized for the realization of the preventive maintenance of the HANARO rotating machinery.

  17. Analyzing Aeroelasticity in Turbomachines

    Science.gov (United States)

    Reddy, T. S. R.; Srivastava, R.

    2003-01-01

    ASTROP2-LE is a computer program that predicts flutter and forced responses of blades, vanes, and other components of such turbomachines as fans, compressors, and turbines. ASTROP2-LE is based on the ASTROP2 program, developed previously for analysis of stability of turbomachinery components. In developing ASTROP2- LE, ASTROP2 was modified to include a capability for modeling forced responses. The program was also modified to add a capability for analysis of aeroelasticity with mistuning and unsteady aerodynamic solutions from another program, LINFLX2D, that solves the linearized Euler equations of unsteady two-dimensional flow. Using LINFLX2D to calculate unsteady aerodynamic loads, it is possible to analyze effects of transonic flow on flutter and forced response. ASTROP2-LE can be used to analyze subsonic, transonic, and supersonic aerodynamics and structural mistuning for rotors with blades of differing structural properties. It calculates the aerodynamic damping of a blade system operating in airflow so that stability can be assessed. The code also predicts the magnitudes and frequencies of the unsteady aerodynamic forces on the airfoils of a blade row from incoming wakes. This information can be used in high-cycle fatigue analysis to predict the fatigue lives of the blades.

  18. Field Deployable DNA analyzer

    Energy Technology Data Exchange (ETDEWEB)

    Wheeler, E; Christian, A; Marion, J; Sorensen, K; Arroyo, E; Vrankovich, G; Hara, C; Nguyen, C

    2005-02-09

    This report details the feasibility of a field deployable DNA analyzer. Steps for swabbing cells from surfaces and extracting DNA in an automatable way are presented. Since enzymatic amplification reactions are highly sensitive to environmental contamination, sample preparation is a crucial step to make an autonomous deployable instrument. We perform sample clean up and concentration in a flow through packed bed. For small initial samples, whole genome amplification is performed in the packed bed resulting in enough product for subsequent PCR amplification. In addition to DNA, which can be used to identify a subject, protein is also left behind, the analysis of which can be used to determine exposure to certain substances, such as radionuclides. Our preparative step for DNA analysis left behind the protein complement as a waste stream; we determined to learn if the proteins themselves could be analyzed in a fieldable device. We successfully developed a two-step lateral flow assay for protein analysis and demonstrate a proof of principle assay.

  19. Analyzing the platelet proteome.

    Science.gov (United States)

    García, Angel; Zitzmann, Nicole; Watson, Steve P

    2004-08-01

    During the last 10 years, mass spectrometry (MS) has become a key tool for protein analysis and has underpinned the emerging field of proteomics. Using high-throughput tandem MS/MS following protein separation, it is potentially possible to analyze hundreds to thousands of proteins in a sample at a time. This technology can be used to analyze the protein content (i.e., the proteome) of any cell or tissue and complements the powerful field of genomics. The technology is particularly suitable for platelets because of the absence of a nucleus. Cellular proteins can be separated by either gel-based methods such as two-dimensional gel electrophoresis or one-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis followed by liquid chromatography (LC) -MS/MS or by multidimensional LC-MS/MS. Prefractionation techniques, such as subcellular fractionations or immunoprecipitations, can be used to improve the analysis. Each method has particular advantages and disadvantages. Proteomics can be used to compare the proteome of basal and diseased platelets, helping to reveal information on the molecular basis of the disease.

  20. Numerical simulation and study of the double regenerative ladle heater with BFG%双蓄热式钢包烘烤器的数值模拟及分析

    Institute of Scientific and Technical Information of China (English)

    刘竹昕; 张卫军

    2014-01-01

    以北兴特钢的高炉煤气双蓄热式钢包烘烤器为背景,采用ANSYS数值模拟预测烘烤情况,分析双蓄热式钢包烘烤器优点,并得出入口射流角度20°左右最佳。%Based on the double regenerative ladle heater with BFG in Beixing special steel factory , a-dopted ANSYS to forecast baking conditions , analyzed the advantage of double regenerative ladle heater and the best entrance angle of jet was 20°.

  1. Improved momentum exchange theory for incompressible regenerative turbomachines

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, I.S.; Chung, M.K. [Korea Advanced Inst. of Science and Technology, Daejon (Korea). Dept. of Mechanical Engineering; Park, M.R. [Korea Inst. of Machinery and Materials, Daejon (Korea)

    2005-11-15

    On the basis of the momentum exchange theory, an improved mathematical model is developed to analyse the complicated helical flow in regenerative turbomachines and to suggest a systematic way to design such kind of machines. The helical flow in the machines is resolved into a peripheral component and a circulatory component, and a theoretically sound method is proposed to calculate the circulatory flow velocity and slip factor, which are closely related to the machine performance. To implement the present method, the concepts of a circulatory pivot and an effectiveness of the circulatory flow are introduced. The circulatory flow loss was successfully estimated by introducing a bend-combination factor by adding four right angle bends losses. It was found that the overall head rise and the hydraulic efficiency can be accurately predicted by the proposed model equation and the present loss models. Development of the static pressure along the peripheral direction could be predicted satisfactorily. (author)

  2. Stem Cell Banking for Regenerative and Personalized Medicine.

    Science.gov (United States)

    Harris, David T

    2014-02-26

    Regenerative medicine, tissue engineering and gene therapy offer the opportunity to treat and cure many of today's intractable afflictions. These approaches to personalized medicine often utilize stem cells to accomplish these goals. However, stem cells can be negatively affected by donor variables such as age and health status at the time of collection, compromising their efficacy. Stem cell banking offers the opportunity to cryogenically preserve stem cells at their most potent state for later use in these applications. Practical stem cell sources include bone marrow, umbilical cord blood and tissue, and adipose tissue. Each of these sources contains stem cells that can be obtained from most individuals, without too much difficulty and in an economical fashion. This review will discuss the advantages and disadvantages of each stem cell source, factors to be considered when contemplating banking each stem cell source, the methodology required to bank each stem cell source, and finally, current and future clinical uses of each stem cell source.

  3. Regenerative oscillation and four-wave mixing in graphene optoelectronics

    CERN Document Server

    Gu, Tingyi; Yang, Xiaodong; McMillian, James F; van der Zander, Arend; Yu, Min-bing; Lo, Guo-Qiang; Kwong, Dim-Lee; Hone, James; Wong, Chee-Wei

    2012-01-01

    The unique linear and massless band structure of graphene, in a purely two-dimensional Dirac fermionic structure, have led to intense research spanning from condensed matter physics to nanoscale device applications covering the electrical, thermal, mechanical and optical domains. Here we report three consecutive first-observations in graphene-silicon hybrid optoelectronic devices: (1) ultralow power resonant optical bistability; (2) self-induced regenerative oscillations; and (3) coherent four-wave mixing, all at a few femtojoule cavity recirculating energies. These observations, in comparison with control measurements with solely monolithic silicon cavities, are enabled only by the dramatically-large and chi(3) nonlinearities in graphene and the large Q/V ratios in wavelength-localized photonic crystal cavities. These results demonstrate the feasibility and versatility of hybrid two-dimensional graphene-silicon nanophotonic devices for next-generation chip-scale ultrafast optical communications, radio-freque...

  4. The matrix reloaded: the evolution of regenerative hydrogels

    Directory of Open Access Journals (Sweden)

    Esmaiel Jabbari

    2016-05-01

    Full Text Available Cell-laden hydrogels can regenerate lost, damaged or malfunctioning tissues. Clinical success of such hydrogels is strongly dependent on the ability to tune their chemical, physico-mechanical, and biological properties to a specific application. In particular, mimicking the intricate arrangement of cell-interactive ligands of natural tissues is crucial to proper tissue function. Natural extracellular matrix elements represent a unique source for generating such interactions. A plethora of extracellular matrix-based approaches have been explored to augment the regenerative potential of hydrogels. These efforts include the development of matrix-like hydrogels, hydrogels containing matrix-like molecules, hydrogels containing decellularized matrix, hydrogels derived from decellularized matrix, and decellularized tissues as reimplantable matrix hydrogels. Here we review the evolution, strengths and weaknesses of these developments from the perspective of creating tissue regenerating hydrogels.

  5. Transient Regenerative Potential of the Neonatal Mouse Heart

    Science.gov (United States)

    Porrello, Enzo R.; Mahmoud, Ahmed I.; Simpson, Emma; Hill, Joseph A.; Richardson, James A.; Olson, Eric N.; Sadek, Hesham A.

    2011-01-01

    Certain fish and amphibians retain a robust capacity for cardiac regeneration throughout life, but the same is not true of the adult mammalian heart. Whether the capacity for cardiac regeneration is absent in mammals or whether it exists and is switched off early after birth has been unclear. We found that the hearts of 1-day-old neonatal mice can regenerate after partial surgical resection, but this capacity is lost by 7 days of age. This regenerative response in 1-day-old mice was characterized by cardiomyocyte proliferation with minimal hypertrophy or fibrosis, thereby distinguishing it from repair processes. Genetic fate mapping indicated that the majority of cardiomyocytes within the regenerated tissue originated from preexisting cardiomyocytes. Echocardiography performed 2 months after surgery revealed that the regenerated ventricular apex had normal systolic function. Thus, for a brief period after birth, the mammalian heart appears to have the capacity to regenerate. PMID:21350179

  6. The clinical use of regenerative therapy in COPD.

    Science.gov (United States)

    Lipsi, Roberto; Rogliani, Paola; Calzetta, Luigino; Segreti, Andrea; Cazzola, Mario

    2014-01-01

    Regenerative or stem cell therapy is an emerging field of treatment based on stimulation of endogenous resident stem cells or administration of exogenous stem cells to treat diseases or injury and to replace malfunctioning or damaged tissues. Current evidence suggests that in the lung, these cells may participate in tissue homeostasis and regeneration after injury. Animal and human studies have demonstrated that tissue-specific stem cells and bone marrow-derived cells contribute to lung tissue regeneration and protection, and thus administration of exogenous stem/progenitor cells or humoral factors responsible for the activation of endogenous stem/progenitor cells may be a potent next-generation therapy for chronic obstructive pulmonary disease. The use of bone marrow-derived stem cells could allow repairing and regenerate the damaged tissue present in chronic obstructive pulmonary disease by means of their engraftment into the lung. Another approach could be the stimulation of resident stem cells by means of humoral factors or photobiostimulation.

  7. Treatment Options: Biological Basis of Regenerative Endodontic Procedures

    Science.gov (United States)

    Hargreaves, Kenneth M.; Diogenes, Anibal; Teixeira, Fabricio B.

    2013-01-01

    Dental trauma occurs frequently in children and often can lead to pulpal necrosis. The occurrence of pulpal necrosis in the permanent but immature tooth represents a challenging clinical situation since the thin and often short roots increase the risk of subsequent fracture. Current approaches for treating the traumatized immature tooth with pulpal necrosis do not reliably achieve the desired clinical outcomes, consisting of healing of apical periodontitis, promotion of continued root development and restoration of the functional competence of pulpal tissue. An optimal approach for treating the immature permanent tooth with a necrotic pulp would be to regenerate functional pulpal tissue. This review summarizes the current literature supporting a biological rationale for considering regenerative endodontic treatment procedures in treating the immature permanent tooth with pulp necrosis. PMID:23439043

  8. Regenerative flywheel energy storage system. Volume 1: Executive summary

    Science.gov (United States)

    1980-06-01

    The development, fabrication, and test of a regenerative flywheel energy storage and recovery system for a battery/flywheel electric vehicle of the 3000 pound class are described. The vehicle propulsion system was simulated on a digital computer in order to determine the optimum system operating strategies and to establish a calculated range improvement over a nonregenerative, all electric vehicle. Fabrication of the inductor motor, the flywheel, the power conditioner, and the system control are described. Test results of the system operating over the SAE J227a Schedule D driving cycle are given and are compared to the calculated value. The flywheel energy storage system consists of a solid rotor, synchronous, inductor type, flywheel drive machine electrically coupled to a dc battery electric propulsion system through a load commutated inverter. The motor/alternator unit is coupled mechanically to a small steel flywheel which provides a portion of the vehicle's accelerating energy and regenerates the vehicle's braking energy.

  9. Error-rate performance analysis of opportunistic regenerative relaying

    KAUST Repository

    Tourki, Kamel

    2011-09-01

    In this paper, we investigate an opportunistic relaying scheme where the selected relay assists the source-destination (direct) communication. In our study, we consider a regenerative opportunistic relaying scheme in which the direct path can be considered unusable, and takes into account the effect of the possible erroneously detected and transmitted data at the best relay. We first derive the exact statistics of each hop, in terms of probability density function (PDF). Then, the PDFs are used to determine accurate closed form expressions for end-to-end bit-error rate (BER) of binary phase-shift keying (BPSK) modulation where the detector may use maximum ration combining (MRC) or selection combining (SC). Finally, we validate our analysis by showing that performance simulation results coincide with our analytical results over linear network (LN) architecture and considering Rayleigh fading channels. © 2011 IEEE.

  10. New results on performance analysis of opportunistic regenerative relaying

    KAUST Repository

    Tourki, Kamel

    2013-12-01

    In this paper, we investigate an opportunistic relaying scheme where the selected relay assists the source-destination (direct) communication. In our study, we consider a regenerative opportunistic relaying scheme in which the direct path may be unusable, and takes into account the effect of the possible erroneously detected and transmitted data at the selected relay. We first derive the signal-to-noise (SNR) statistics for each hop, which are used to determine accurate closed form expressions for end-to-end bit-error rate (BER) of binary phase-shift keying (BPSK) modulation and end-to-end outage probability for a transmission rate R over Rayleigh fading channels. Furthermore, we evaluate the asymptotical performance and deduce the diversity order. Finally, we validate our analysis by showing that performance simulation results coincide with our analytical results over linear network architecture. © 2013 Elsevier B.V.

  11. A Regenerative Prediction Algorithm for Indian Rainfall Prediction

    Directory of Open Access Journals (Sweden)

    SEEMA MAHAJAN

    2013-11-01

    Full Text Available Rainfall forecasting is critical for the crop planning and water management strategies. Proposed study presents a novel approach for modelling time series precipitation data. The 51 years of Indian rainfall data is used for the development of the model. We use nonlinear predictive code based on 11th order with 240 coefficients. Coefficients are optimized using gradient descendent algorithm. Algorithm is tested using 40 years of rainfall training data. Prediction error tested outside training period is found less than1% for few months. Prediction period is extended to one year by including progressive predicted values in input samples using regenerative feedback algorithm. This model is applied for different training and testing periods with average error of 2% to 10%.

  12. Regenerative surgery: tissue engineering in general surgical practice.

    Science.gov (United States)

    Wong, Victor W; Wan, Derrick C; Gurtner, Geoffrey C; Longaker, Michael T

    2012-10-01

    Tissue engineering is a broad interdisciplinary field that aims to develop complex tissue and organ constructs through a combination of cell-, biomaterial-, and molecular-based approaches. This approach has the potential to transform the surgical treatment for diseases including trauma, cancer, and congenital malformations. A fundamental knowledge of key concepts in regenerative medicine is imperative for surgeons to maintain a leading role in developing and implementing these technologies. Researchers have started to elucidate the biologic mechanisms that maintain organ homeostasis throughout life, indicating that humans may have the latent capacity to regenerate complex tissues. By exploiting this intrinsic potential of the body, we can move even closer to developing functional, autologous replacement parts for a wide range of surgical diseases.

  13. Chitosan and fish collagen as biomaterials for regenerative medicine.

    Science.gov (United States)

    Hayashi, Yoshihiko; Yamada, Shizuka; Yanagi Guchi, Kajiro; Koyama, Zenya; Ikeda, Takeshi

    2012-01-01

    This chapter focuses and reviews on the characteristics and biomedical application of chitosan and collagen from marine products and advantages and disadvantages of regeneration medicine. The understanding of the production processes of chitosan and collagen and the conformation of these biomaterials are indispensable for promoting the theoretical and practical availability. The initial inflammatory reactions associated with chitosan application to hard and soft tissues need to be controlled before it can be considered for clinical application as scaffold. Further, as chitosan takes too long for biodegradation in vivo, generally it is not suitable for the scaffold for degenerative medicine in especially dental pulp tissue. The collagen extract from the scales of tropical fish has been reported to have a degeneration temperature of 35°C. The properties of biocompatibility and biodegradation of fish atelocollagen are suitable for the scaffold in regenerative medicine.

  14. Multiple regenerative techniques for class II furcation defect

    Directory of Open Access Journals (Sweden)

    Pushpendra Kumar Verma

    2012-01-01

    Full Text Available Regeneration of the periodontium is a major goal in the treatment of teeth affected by periodontitis. Periodontal regeneration is quite challenging, especially when it is in the furcation area. There are several techniques used alone or in combination, considered to achieve periodontal regeneration, including bone grafts or substitutes, guided tissue regeneration, root surface modification, and biological mediators. Many factors may account for variability in the response to regenerative therapy in class II furcation. This case report describes the management of a buccal class II furcation defect, with the help of surgical intervention, including the guided tissue regeneration (GTR membrane and bone graft materials. This combined treatment resulted in a healthy periodontium, with radiographic evidence of alveolar bone gain. This case report demonstrates that proper diagnosis, followed by removal of the etiological factors and utilizing combined treatment modalities, restored health and function of the tooth with severe attachment loss, at the 18-month follow-up.

  15. Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications

    Directory of Open Access Journals (Sweden)

    Anna Gilpin

    2017-01-01

    Full Text Available As the gap between donors and patients in need of an organ transplant continues to widen, research in regenerative medicine seeks to provide alternative strategies for treatment. One of the most promising techniques for tissue and organ regeneration is decellularization, in which the extracellular matrix (ECM is isolated from its native cells and genetic material in order to produce a natural scaffold. The ECM, which ideally retains its inherent structural, biochemical, and biomechanical cues, can then be recellularized to produce a functional tissue or organ. While decellularization can be accomplished using chemical and enzymatic, physical, or combinative methods, each strategy has both benefits and drawbacks. The focus of this review is to compare the advantages and disadvantages of these methods in terms of their ability to retain desired ECM characteristics for particular tissues and organs. Additionally, a few applications of constructs engineered using decellularized cell sheets, tissues, and whole organs are discussed.

  16. Reduction of Train-induced Vibrations by using Barriers

    Directory of Open Access Journals (Sweden)

    Giovanni Leonardi

    2014-05-01

    Full Text Available The problem of the ground-borne vibration caused by high speed trains has received considerable attention in recent years, due to the effects of vibration on buildings, in terms of physical damage and on population, in terms of discomfort. The problem has become more significant with the increase of speed and weight of trains, which results in heavier loads on the tracks. Therefore, there is the necessity to find a method, which allows investigating the propagation of vibration waves in the soil. This study aims to study the train-induced ground vibration and the mitigation effects of barriers using a Finite Element Method (FEM model. Two different types of barriers were evaluated considering their stiffness and a benchmark model without mitigation measures was also analyzed to evaluate the effectiveness of the considered barriers. The results of the proposed elaborations have been finalized to the assessment of the incidence of the barrier on the vibration state induced from the passage of a high speed trains and the following conclusions can be made: concrete seems to provide a significative reduction of the vibration. The proposed method can be successfully applied to a preliminary analysis of the influence of different types of barriers on the dynamic properties of vibration waves in the soil.

  17. Dynamics of Multistage Gear Transmission with Effects of Gearbox Vibrations

    Science.gov (United States)

    Choy, F. K.; Tu, Y. K.; Zakrajsek, J. J.; Townsend, Dennis P.

    1990-01-01

    A comprehensive approach is presented in analyzing the dynamic behavior of multistage gear transmission systems with the effects of gearbox induced vibrations and mass imbalances of the rotor. The modal method, with undamped frequencies and planar mode shapes, is used to reduce the degrees of freedom of the gear system for time-transient dynamic analysis. Both the lateral and torsional vibration modes of each rotor-bearing-gear stage as well as the interstage vibrational characteristics are coupled together through localized gear mesh tooth interactions. In addition, gearbox vibrations are also coupled to the rotor-bearing-gear system dynamics through bearing support forces between the rotor and the gearbox. Transient and steady state dynamics of lateral and torsional vibrations of the geared system are examined in both time and frequency domains to develop interpretations of the overall modal dynamic characteristics under various operating conditions. A typical three-stage geared system is used as an example. Effects of mass imbalance and gearbox vibrations on the system dynamic behavior are presented in terms of modal excitation functions for both lateral and torsional vibrations. Operational characteristics and conclusions are drawn from the results presented.

  18. Attenuation of cryocooler induced vibration in spaceborne infrared payloads

    Science.gov (United States)

    Veprik, A.; Twitto, A.

    2014-01-01

    Recent advancement of operational responsive space programs calls for a development of compact, reliable, low power and vibration free cryogenic cooling for sophisticated infrared payloads. The refrigeration in a typical closed cycle split Stirling linear cryocooler is achieved by a cyclic compression and expansion of a gaseous working agent due to a synchronized reciprocation of electro-dynamically and pneumatically actuated compressor and expander pistons. Attenuation of the cryocooler induced vibration usually relies on the concept of actively assisted momentum cancellation. In a typical dual-piston compressor this objective is achieved by actively synchronizing the motion of oppositely moving piston assemblies; a typical single-piston expander may be counterbalanced by a motorized counter-balancer. The above approach produces complexity, weight, size, high incurred costs and affects reliability. The authors analyze the case of passive attenuation the vibration export induced by the split Stirling linear cryocooler comprised of inline mounted single-piston compressor and expander. Placement of all the moving components onto a common axis results in a single axis consolidation of vibration export and enables use of single tuned dynamic absorber and low frequency vibration mount. From theoretical analysis and full-scale testing, the performance of such vibration protection arrangement is similar to known systems of active vibration cancellation.

  19. Modality-Specific Axonal Regeneration: Towards selective regenerative neural interfaces

    Directory of Open Access Journals (Sweden)

    Parisa eLotfi

    2011-10-01

    Full Text Available Regenerative peripheral nerve interfaces have been proposed as viable alternatives for the natural control of robotic prosthetic devices. However, sensory and motor axons at the neural interface are of mixed submodality types, which difficult the specific recording from motor axons and the eliciting of precise sensory modalities through selective stimulation. Here we evaluated the possibility of using type-specific neurotrophins to preferentially entice the regeneration of defined axonal populations from transected peripheral nerves into separate compartments. Segregation of mixed sensory fibers from dorsal root ganglion neurons was evaluated in vitro by compartmentalized diffusion delivery of nerve growth factor (NGF and neurotrophin-3 (NT-3, to preferentially entice the growth of TrkA+ nociceptive and TrkC+ proprioceptive subsets of sensory neurons, respectively. The average axon length in the NGF channel increased 2.5 fold compared to that in saline or NT-3, whereas the number of branches increased 3 fold in the NT-3 channels. These results were confirmed using a 3-D Y-shaped in vitro assay showing that the arm containing NGF was able to entice a 5-fold increase in axonal length of unbranched fibers. To address if such segregation can be enticed in vivo, a Y-shaped tubing was used to allow regeneration of the transected adult rat sciatic nerve into separate compartments filled with either NFG or NT-3. A significant increase in the number of CGRP+ pain fibers were attracted towards the sural nerve, while N-52+ large diameter axons were observed in the tibial and NT-3 compartments. This study demonstrates the guided enrichment of sensory axons in specific regenerative chambers, and supports the notion that neurotrophic factors can be used to segregate sensory and perhaps motor axons in separate peripheral interfaces.

  20. Development of a Microwave Regenerative Sorbent-Based Hydrogen Purifier

    Science.gov (United States)

    Wheeler, Richard R., Jr.; Dewberry, Ross H.; McCurry, Bryan D.; Abney, Morgan B.; Greenwood, Zachary W.

    2016-01-01

    This paper describes the design and fabrication of a Microwave Regenerative Sorbent-based Hydrogen Purifier (MRSHP). This unique microwave powered technology was developed for the purification of a hydrogen stream produced by the Plasma Pyrolysis Assembly (PPA). The PPA is a hydrogen recovery (from methane) post processor for NASA's Sabatier-based carbon dioxide reduction process. Embodied in the Carbon dioxide Reduction Assembly (CRA), currently aboard the International Space Station (ISS), the Sabatier reaction employs hydrogen to catalytically recover oxygen, in the form of water, from respiratory carbon dioxide produced by the crew. This same approach is base-lined for future service in the Air Revitalization system on extended missions into deep space where resupply is not practical. Accordingly, manned exploration to Mars may only become feasible with further closure of the air loop as afforded by the greater hydrogen recovery permitted by the PPA with subsequent hydrogen purification. By utilizing the well-known high sorbate loading capacity of molecular sieve 13x, coupled with microwave dielectric heating phenomenon, MRSHP technology is employed as a regenerative filter for a contaminated hydrogen gas stream. By design, freshly regenerated molecular sieve 13x contained in the MRSHP will remove contaminants from the effluent of a 1-CM scale PPA for several hours prior to breakthrough. By reversing flow and pulling a relative vacuum the MRSHP prototype then uses 2.45 GHz microwave power, applied through a novel coaxial antenna array, to rapidly heat the sorbent bed and drive off the contaminants in a short duration vacuum/thermal contaminant desorption step. Finally, following rapid cooling via room temperature cold plates, the MRSHP is again ready to serve as a hydrogen filter.