Preliminary description of hydrologic characteristics and contaminant transport potential of rocks in the Pasco Basin, south-central Washington

International Nuclear Information System (INIS)

Deju, R.A.; Fecht, K.R.

1979-03-01

This report aims at consolidating existing data useful in defining the hydrologic characteristics of the Pasco Basin within south-central Washington. It also aims at compiling the properties required to evaluate contaminant transport potential within individual subsurface strata in this basin. The Pasco Basin itself is a tract of semi-arid land covering about 2,000 square miles in south-central Washington. The regional geology of this basin is dominated by tholeiitic flood basalts of the Columbia Plateau. The surface hydrology of the basin is dominated by the Yakima, Snake, and Columbia rivers. Short-lived ephemeral streams may flow for a short period of time after a heavy rainfall or snowmelt. The subsurface hydrology of the Pasco Basin is characterized by an unconfined aquifer carrying the bulk of the water discharged within the basin. This aquifer overlies a series of confined aquifers carrying progressively smaller amounts of groundwater as a function of depth. The hydraulic properties of the various aquifers and non-water-bearing strata are characterized and reported. A summary of the basic properties is tabulated. The hydrochemical data obtained are summarized. The contaminant transport properties of the rocks in the Pasco Basin are analyzed with emphasis on the dispersion and sorption coefficients and the characteristics of the potential reactions between emplaced waste and the surrounding medium. Some basic modeling considerations of the hydrogeologic systems in the basin with a brief discussion of model input requirements and their relationship to available data are presented

29 CFR 18.612 - Writing used to refresh memory.

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Writing used to refresh memory. 18.612 Section 18.612 Labor... OFFICE OF ADMINISTRATIVE LAW JUDGES Rules of Evidence Witnesses § 18.612 Writing used to refresh memory. If a witness uses a writing to refresh memory for the purpose of testifying, either while testifying...

Information and Announcements Refresher Course on Advanced ...

Indian Academy of Sciences (India)

A Refresher Course on "Advanced Topics in Chemistry" for college / university teachers. The aim of the Refresher Course is to enrich the knowledge of teachers in the following proposed topics and enable them to teach the subject to graduate students effectively. (a) Solid State Chemistry and Nanomaterials.

Determination of Columbia River flow times from Pasco, Washington using radioactive tracers introduced by the Hanford reactors

Science.gov (United States)

Nelson, Jack L.; Perkins, R.W.; Haushild, W.L.

1966-01-01

Radioactive tracers introduced into the Columbia River in cooling water from the Hanford reactors were used to measure flow times downstream from Pasco, Washington, as far as Astoria, Oregon. The use of two tracer methods was investigated. One method used the decay of a steady release of Na24 (15-hour half-life) to determine flow times to various downstream locations, and flow times were also determined from the time required for peak concentration of instantaneous releases of I131 (8-day half-life) to reach these locations. Flow times determined from the simultaneous use of the two methods agreed closely. The measured flow times for the 224 miles from Pasco to Vancouver, Washington, ranged from 14.6 to 3.6 days, respectively, for discharges of 108,000 and 630,000 ft3/sec at Vancouver, Washington. A graphic relation for estimating flow times at discharges other than those measured and for several locations between Pasco and Vancouver was prepared from the data of tests made at four river discharges. Some limited data are also presented on the characteristics of dispersion of I131 in the Columbia River.

Science Academies' Refresher Course on Bioprospection of ...

Indian Academy of Sciences (India)

2017-11-22

Nov 22, 2017 ... A refresher course on 'Bioprospection of Bioresources: Land to Lab Approach' will be held at PG and Research Department of Botany, St. Joseph's College, Tiruchirappalli, Tamil Nadu for two weeks from 04–18 January,2018. The aim of the Refresher Course is to encourage the College teachers and ...

Work Programme 2010. Nordic Energy Regulators (NordREG)

Energy Technology Data Exchange (ETDEWEB)

2010-02-15

The Nordic regulators' cooperation through NordREG is based on a strong consensus and common understanding of the Nordic market. Through mutual efforts and contributions NordREG members identify areas of work that can create added value for the Nordic electricity market. NordREG works by exchanging information and views, mapping and analysing energy market issues and by delivering statements and reports for harmonisation and improvement. In this, the regulators aim at identifying areas where NordREG can take joint action to influence Nordic or European electricity market development. NordREGs key focus in 2010 is the work towards a common Nordic retail market and the emphasis is on promoting a legal and institutional framework that supports this goal

Sensory basis of refreshing perception: role of psychophysiological factors and food experience.

Science.gov (United States)

Labbe, D; Almiron-Roig, E; Hudry, J; Leathwood, P; Schifferstein, H N J; Martin, N

2009-08-04

Refreshing is a term often used to characterize certain types of foods and beverages. This review first explores what is known from sensory and consumer studies on refreshing perception in relation to food and beverage consumption. It then presents and discusses the similarities between sensory characteristics perceived as refreshing with those perceived during and after drinking water. In general, refreshing drinks and beverages seem to help alleviate symptoms experienced during water deprivation, including thirst, mouth dryness and mental fatigue. The role that learning may have in the construction of refreshing perception during each food experience is also discussed. The review showed that a refreshing value (perceived or expected) tends to be associated with foods sharing some characteristics with water in terms of their sensory profile (clear, cold, liquid); and that food experiences may induce associative learning about perceptions of existing or new products marketed as refreshing.

Configuration and debug of field programmable gate arrays using MATLAB[reg)/SIMULINK[reg

International Nuclear Information System (INIS)

Grout, I; Ryan, J; O'Shea, T

2005-01-01

Increasingly, the need to seamlessly link high-level behavioural descriptions of electronic hardware for modelling and simulation purposes to the final application hardware highlights the gap between the high-level behavioural descriptions of the required circuit functionality (considering here digital logic) in commonly used mathematical modelling tools, and the hardware description languages such as VHDL and Verilog-HDL. In this paper, the linking of a MATLAB[reg] model for digital algorithm for implementation on a programmable logic device for design synthesis from the MATLAB[reg] model into VHDL is discussed. This VHDL model is itself synthesised and downloaded to the target Field Programmable Gate Array, for normal operation and also for design debug purposes. To demonstrate this, a circuit architecture mapped from a SIMULINK[reg] model is presented. The rationale is for a seamless interface between the initial algorithm development and the target hardware, enabling the hardware to be debugged and compared to the simulated model from a single interface for use with by a non-expert in the programmable logic and hardware description language use

Expression of REG family genes in human inflammatory bowel diseases and its regulation

Directory of Open Access Journals (Sweden)

Chikatsugu Tsuchida

2017-12-01

Full Text Available The pathophysiology of inflammatory bowel disease (IBD reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg family members have been reported to be expressed in Crohn's disease (CD and ulcerative colitis (UC and to be involved as proliferative mucosal factors in IBD. However, expression of all REG family genes in IBD is still unclear. Here, we analyzed expression of all REG family genes (REG Iα, REG Iβ, REG III, HIP/PAP, and REG IV in biopsy specimens of UC and CD by real-time RT-PCR. REG Iα, REG Iβ, and REG IV genes were overexpressed in CD samples. REG IV gene was also overexpressed in UC samples. We further analyzed the expression mechanisms of REG Iα, REG Iβ, and REG IV genes in human colon cells. The expression of REG Iα was significantly induced by IL-6 or IL-22, and REG Iβ was induced by IL-22. Deletion analyses revealed that three regions (− 220 to − 211, − 179 to − 156, and − 146 to − 130 in REG Iα and the region (− 274 to− 260 in REG Iβ promoter were responsible for the activation by IL-22/IL-6. The promoters contain consensus transcription factor binding sequences for MZF1, RTEF1/TEAD4, and STAT3 in REG Iα, and HLTF/FOXN2F in REG Iβ, respectively. The introduction of siRNAs for MZF1, RTEF1/TEAD4, STAT3, and HLTF/FOXN2F abolished the transcription of REG Iα and REG Iβ. The gene activation mechanisms of REG Iα/REG Iβ may play a role in colon mucosal regeneration in IBD.

Evidence for spontaneous serial refreshing in verbal working memory?

Science.gov (United States)

Vergauwe, Evie; Langerock, Naomi; Cowan, Nelson

2018-04-01

Working memory (WM) keeps information temporarily accessible for ongoing cognition. One proposed mechanism to keep information active in WM is refreshing. This mechanism is assumed to operate by bringing memory items into the focus of attention, thereby serially refreshing the content of WM. We report two experiments in which we examine evidence for the spontaneous occurrence of serial refreshing in verbal WM. Participants had to remember series of red letters, while black probe letters were presented between these memory items, with each probe to be judged present in or absent from the list presented so far, as quickly as possible (i.e., the probe-span task). Response times to the probes were used to infer the status of the representations in WM and, in particular, to examine whether the content of the focus of attention changed over time, as would be expected if serial refreshing occurs spontaneously during inter-item pauses. In sharp contrast with this hypothesis, our results indicate that the last-presented memory item remained in the focus of attention during the inter-item pauses of the probe-span task. We discuss how these findings help to define the boundary conditions of spontaneous refreshing of verbal material in WM, and discuss implications for verbal WM maintenance and forgetting.

Refreshing memory traces: thinking of an item improves retrieval from visual working memory.

Science.gov (United States)

Souza, Alessandra S; Rerko, Laura; Oberauer, Klaus

2015-03-01

This article provides evidence that refreshing, a hypothetical attention-based process operating in working memory (WM), improves the accessibility of visual representations for recall. "Thinking of", one of several concurrently active representations, is assumed to refresh its trace in WM, protecting the representation from being forgotten. The link between refreshing and WM performance, however, has only been tenuously supported by empirical evidence. Here, we controlled which and how often individual items were refreshed in a color reconstruction task by presenting cues prompting participants to think of specific WM items during the retention interval. We show that the frequency with which an item is refreshed improves recall of this item from visual WM. Our study establishes a role of refreshing in recall from visual WM and provides a new method for studying the impact of refreshing on the amount of information we can keep accessible for ongoing cognition. © 2014 New York Academy of Sciences.

Refreshable Braille displays using EAP actuators

Science.gov (United States)

Bar-Cohen, Yoseph

2010-04-01

Refreshable Braille can help visually impaired persons benefit from the growing advances in computer technology. The development of such displays in a full screen form is a great challenge due to the need to pack many actuators in small area without interferences. In recent years, various displays using actuators such as piezoelectric stacks have become available in commercial form but most of them are limited to one line Braille code. Researchers in the field of electroactive polymers (EAP) investigated methods of using these materials to form full screen displays. This manuscript reviews the state of the art of producing refreshable Braille displays using EAP-based actuators.

Refreshable Braille Displays Using EAP Actuators

Science.gov (United States)

Bar-Cohen, Yoseph

2010-01-01

Refreshable Braille can help visually impaired persons benefit from the growing advances in computer technology. The development of such displays in a full screen form is a great challenge due to the need to pack many actuators in small area without interferences. In recent years, various displays using actuators such as piezoelectric stacks have become available in commercial form but most of them are limited to one line Braille code. Researchers in the field of electroactive polymers (EAP) investigated methods of using these materials to form full screen displays. This manuscript reviews the state of the art of producing refreshable Braille displays using EAP-based actuators..

Where to attend next: guiding refreshing of visual, spatial, and verbal representations in working memory.

Science.gov (United States)

Souza, Alessandra S; Vergauwe, Evie; Oberauer, Klaus

2018-04-23

One of the functions that attention may serve in working memory (WM) is boosting information accessibility, a mechanism known as attentional refreshing. Refreshing is assumed to be a domain-general process operating on visual, spatial, and verbal representations alike. So far, few studies have directly manipulated refreshing of individual WM representations to measure the WM benefits of refreshing. Recently, a guided-refreshing method was developed, which consists of presenting cues during the retention interval of a WM task to instruct people to refresh (i.e., attend to) the cued items. Using a continuous-color reconstruction task, previous studies demonstrated that the error in reporting a color varies linearly with the frequency with which it was refreshed. Here, we extend this approach to assess the WM benefits of refreshing different representation types, from colors to spatial locations and words. Across six experiments, we show that refreshing frequency modulates performance in all stimulus domains in accordance with the tenet that refreshing is a domain-general process in WM. The benefits of refreshing were, however, larger for visual-spatial than verbal materials. © 2018 New York Academy of Sciences.

Rapid Refresh (RAP) [13 km

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Refresh (RAP) numerical weather model took the place of the Rapid Update Cycle (RUC) on May 1, 2012. Run by the National Centers for Environmental...

Rapid Refresh (RAP) [20 km

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Refresh (RAP) numerical weather model took the place of the Rapid Update Cycle (RUC) on May 1, 2012. Run by the National Centers for Environmental...

Repository site definition in basalt: Pasco Basin, Washington

Energy Technology Data Exchange (ETDEWEB)

Guzowski, R.V.; Nimick, F.B.; Muller, A.B.

1982-03-01

Discussion of the regional setting, geology, hydrology, and geochemistry of the Pasco Basin are included in this report. Pasco basin is a structural and topographic basin of approximately 2000 mi/sup 2/ (5180 km/sup 2/) located within the Yakima Fold Belt Subprovince of the Columbia Plateau. The stratigraphic sequence within the basin consists of an undetermined thickness of lower Miocene and younger flood basalts with interbedded and overlying sedimentary units. This sequence rests upon a basement of probably diverse rock types that may range in age from precambrian through early Tertiary. Although a large amount of information is available on the hydrology of the unconfined aquifer system, ground-water flow within the basin is, in general, poorly understood. Recharge areas for the Mabton interbed and the Saddle Mountains Formation are the highlands surrounding the basin with the flow for these units toward Gable Butte - Gable Mountain and Lake Wallula. Gable Butte - Gable Mountain probably is a ground-water sink, although the vertical flow direction in this zone is uncertain. The amount of upward vertical leakage from the Saddle Mountains Formation into the overlying sediments or to the Columbia River is unknown. Units underlying the Mabton interbed may have a flow scheme similar to those higher units or a flow scheme dominated by interbasin flow. Upward vertical leakage either throughout the basin, dominantly to the Columbia River, or dominantly to Lake Wallula has been proposed for the discharge of the lower units. None of these proposals is verified. The lateral and vertical distribution of major and minor ions in solution, Eh and pH, and ion exchange between basalt and ground-water are not well defined for the basin. Changes in the redox potential from the level of the subsurface facility to the higher stratigraphic levels along with the numerous other factors influencing K/sub d/, result in a poor understanding of the retardation process.

Repository site definition in basalt: Pasco Basin, Washington

International Nuclear Information System (INIS)

Guzowski, R.V.; Nimick, F.B.; Muller, A.B.

1982-03-01

Discussion of the regional setting, geology, hydrology, and geochemistry of the Pasco Basin are included in this report. Pasco basin is a structural and topographic basin of approximately 2000 mi 2 (5180 km 2 ) located within the Yakima Fold Belt Subprovince of the Columbia Plateau. The stratigraphic sequence within the basin consists of an undetermined thickness of lower Miocene and younger flood basalts with interbedded and overlying sedimentary units. This sequence rests upon a basement of probably diverse rock types that may range in age from precambrian through early Tertiary. Although a large amount of information is available on the hydrology of the unconfined aquifer system, ground-water flow within the basin is, in general, poorly understood. Recharge areas for the Mabton interbed and the Saddle Mountains Formation are the highlands surrounding the basin with the flow for these units toward Gable Butte - Gable Mountain and Lake Wallula. Gable Butte - Gable Mountain probably is a ground-water sink, although the vertical flow direction in this zone is uncertain. The amount of upward vertical leakage from the Saddle Mountains Formation into the overlying sediments or to the Columbia River is unknown. Units underlying the Mabton interbed may have a flow scheme similar to those higher units or a flow scheme dominated by interbasin flow. Upward vertical leakage either throughout the basin, dominantly to the Columbia River, or dominantly to Lake Wallula has been proposed for the discharge of the lower units. None of these proposals is verified. The lateral and vertical distribution of major and minor ions in solution, Eh and pH, and ion exchange between basalt and ground-water are not well defined for the basin. Changes in the redox potential from the level of the subsurface facility to the higher stratigraphic levels along with the numerous other factors influencing K/sub d/, result in a poor understanding of the retardation process

Análisis de regímenes aduaneros

OpenAIRE

Maruri P., Cristina

2010-01-01

El presente documento contiene el análisis de cada Régimen Aduanero que las empresas en calidad de Exportadores e Importadores deben utilizar para un mejor manejo de sus actividades comerciales Internacionales. Los Regímenes Aduaneros se clasifican: Regímenes Comunes, Especiales, Particulares y de Excepción cada uno de ellos con subdivisión, sus definiciones, los requisitos y garantías que se debe cumplir de acuerdo a cada actividad empresarial. El documento cuenta también con ejemplo de Regí...

Calculus refresher

CERN Document Server

Klaf, A A

1956-01-01

This book is unique in English as a refresher for engineers, technicians, and students who either wish to brush up their calculus or find parts of calculus unclear. It is not an ordinary textbook. It is, instead, an examination of the most important aspects of integral and differential calculus in terms of the 756 questions most likely to occur to the technical reader. It provides a very easily followed presentation and may also be used as either an introductory or supplementary textbook. The first part of this book covers simple differential calculus, with constants, variables, functions, inc

Erosion potential from Missoula floods in the Pasco Basin, Washington

International Nuclear Information System (INIS)

Craig, R.G.; Hanson, J.P.

1985-12-01

Localities within the Pasco Basin preserve evidence of Missoula floods. Deposits are 46% sand-sized, 36% gravel-sized, and 18% finer than sand-sized. Mean thickness is 39 meters. High water marks at Wallula Gap require a discharge of approximately 12.5 Mcms. At Sentinel Gap, the slope-area method shows that the high water marks require a discharge of 34.6 Mcms. Since this discharge greatly exceeds any estimated for Missoula floods, there must have been backwater ponding from Wallula Gap. Projecting the slope of the water surface at the upper end of Wallula Gap to the downstream cross section at Gable Mountain leads to a discharge of 9.5 Mcms at Sentinel Gap. The HEC-6 steady state code and four sediment transport equations were applied. Assuming sand-sized particles, DuBoys function estimated 4 to 9 meters of scour. Yang's equation estimated 3 to 4 meters of scour. These are a minimum. A hydrograph synthesized for the boundaries of the Pasco Basin shows the maxima of the flood would occur after 90 h at Sentinel Gap, and at 114 h at Wallula Gap. The 200 areas will remain inundated for four days and six hours. With a quasi-dynamic sediment transport computation, HEC-6 scour estimates range from 0.61 meters to 0.915 meters. This is a minimum amount and erosion is highly variable suggesting reworking of sediment. The Meyer-Peter Meuller equations show less than 1 meter of net scour in the 200 areas. More extensive erosion was achieved during particular time steps of this analysis suggesting that sediment re-working would occur

Erosion potential from Missoula floods in the Pasco Basin, Washington

Energy Technology Data Exchange (ETDEWEB)

Craig, R.G.; Hanson, J.P.

1985-12-01

Localities within the Pasco Basin preserve evidence of Missoula floods. Deposits are 46% sand-sized, 36% gravel-sized, and 18% finer than sand-sized. Mean thickness is 39 meters. High water marks at Wallula Gap require a discharge of approximately 12.5 Mcms. At Sentinel Gap, the slope-area method shows that the high water marks require a discharge of 34.6 Mcms. Since this discharge greatly exceeds any estimated for Missoula floods, there must have been backwater ponding from Wallula Gap. Projecting the slope of the water surface at the upper end of Wallula Gap to the downstream cross section at Gable Mountain leads to a discharge of 9.5 Mcms at Sentinel Gap. The HEC-6 steady state code and four sediment transport equations were applied. Assuming sand-sized particles, DuBoys function estimated 4 to 9 meters of scour. Yang's equation estimated 3 to 4 meters of scour. These are a minimum. A hydrograph synthesized for the boundaries of the Pasco Basin shows the maxima of the flood would occur after 90 h at Sentinel Gap, and at 114 h at Wallula Gap. The 200 areas will remain inundated for four days and six hours. With a quasi-dynamic sediment transport computation, HEC-6 scour estimates range from 0.61 meters to 0.915 meters. This is a minimum amount and erosion is highly variable suggesting reworking of sediment. The Meyer-Peter Meuller equations show less than 1 meter of net scour in the 200 areas. More extensive erosion was achieved during particular time steps of this analysis suggesting that sediment re-working would occur.

oordrag van eiendomsreg in die vulgêre reg in die wes-romeinse ryk

African Journals Online (AJOL)

Mnr F Schutte

klassieke. Romeinse reg (250vC-27vC), klassieke Romeins reg (27vC-250nC), na-klassieke Romeinse reg. (250nC-1100nC). Sien verder ook Van Zyl Romeinse Privaatreg. 3 Die vulgêre reg het die klassieke reg in die tydperk tussen 350 en ...

New refresher training in the use of self-rescue masks

CERN Multimedia

HSE Unit

2012-01-01

Photos of the training session for self-rescue mask instructors held on 21 March 2012 – 10 new instructors followed the coursePhotos of the training session for self-rescue mask instructors held on 21 March 2012 – 10 new instructors followed the course   A refresher course in the use of self-rescue masks has been added to the CERN training catalogue. Sign up! More than 3500 people have followed the course since it was introduced in 2009. Taking account of the forthcoming long shutdown, requests for follow-up training from course participants and recent changes in the course content, the HSE Unit has decided to place a three-year limit on the validity of the initial training and to introduce a refresher course. The new refresher course is open to all personnel having completed the initial course at least 2 years ago. The course, "Recyclage Formation masque auto-sauveteur » / "Refresher course Self-Rescue Mask Training", (code No. 077...

BacillusRegNet

DEFF Research Database (Denmark)

Misirli, Goksel; Hallinan, Jennifer; Röttger, Richard

2014-01-01

As high-throughput technologies become cheaper and easier to use, raw sequence data and corresponding annotations for many organisms are becoming available. However, sequence data alone is not sufficient to explain the biological behaviour of organisms, which arises largely from complex molecular...... the associated BacillusRegNet website (http://bacillus.ncl.ac.uk)....

Interpretation of magnetotelluric data: Pasco Basin, south central Washington

International Nuclear Information System (INIS)

Orange, A.; Berkman, E.

1985-01-01

The purpose of this project was to review, evaluate, and interpret magnetotelluric (MT) data collected in support of the Basalt Waste Isolation Project. The integrated interpretation presented is related to regional and site-specific geology and associated borehole, gravity, and magnetic data. The MT interpretation procedure placed strong reliance on computer models based upon the inferred physical parameters of the subsurface materials and their anticipated variability. Much of the MT data is of poor quality by current standards; however, significant qualitative observations can be made. The quantification of these observations, including the procedures and assumption utilized, are discussed in detail. Problems related to ambiguities inherent in the MT method are discussed as related to the Pasco Basin MT data. 117 refs., 77 figs., 3 tabs

Effects of feed refreshing frequency on growth and carcass ...

African Journals Online (AJOL)

Sixty, two-month old male Awassi lambs were used in this study to investigate the effects of feed refreshing (FR) frequencies on their growth and carcass characteristics over a period of 65 days. Treatments were: Feed refreshing at 2 h (FR2), 4 h (FR4), 8 h (FR8), 12 h (FR12) and 24 h (FR24) intervals. The lambs were fed ...

REG4 independently predicts better prognosis in non-mucinous colorectal cancer.

Directory of Open Access Journals (Sweden)

Tuomas Kaprio

Full Text Available INTRODUCTION: Colorectal cancer (CRC is one of the world's three most common cancers and its incidence is rising. To identify patients who benefit from adjuvant therapy requires novel biomarkers. The regenerating islet-derived gene (REG 4 belongs to a group of small secretory proteins involved in cell proliferation and regeneration. Its up-regulated expression occurs in inflammatory bowel diseases also in gastrointestinal cancers. Reports on the association of REG4 expression with CRC prognosis have been mixed. Our aim was to investigate tumor REG4 expression in CRC patients and its coexpression with other intestinal markers. METHODS: Tumor expression of REG4 was evaluated by immunohistochemistry in 840 consecutive surgically treated CRC patients at Helsinki University Central Hospital. Expression of MUC1, MUC2, MUC5AC, synapthophysin, and chromogranin was evaluated in a subgroup of 220 consecutively operated CRC patients. REG4 expression with clinicopathological parameters, other intestinal markers, and the impact of REG4 expression on survival were assessed. RESULTS: REG4 expression associated with favorable clinicopathological parameters and with higher overall survival from non-mucinous CRC (p = 0.019. For such patients under 65, its expression was an independent marker of lower risk of death within 5 years that cancer; univariable hazard ratio (HR = 0.57; 95% confidence interval (CI (0.34-0.94; multivariable HR = 0.55; 95% CI (0.33-0.92. In non-mucinous CRC, REG4 associated with positive MUC2, MUC4, and MUC5AC expression. CONCLUSION: We show, to our knowledge for the first time, that REG4 IHC expression to be an independent marker of favorable prognosis in non-mucinous CRC. Our results contradict those from studies based on quantification of REG4 mRNA levels, a discrepancy warranting further studies.

Maintenance of memory for melodies: Articulation or attentional refreshing?

Science.gov (United States)

Nees, Michael A; Corrini, Ellen; Leong, Peri; Harris, Joanna

2017-12-01

Past research on the effects of articulatory suppression on working memory for nonverbal sounds has been characterized by discrepant findings, which suggests that multiple mechanisms may be involved in the rehearsal of nonverbal sounds. In two experiments we examined the potential roles of two theoretical mechanisms of verbal working memory-articulatory rehearsal and attentional refreshing-in the maintenance of memory for short melodies. In both experiments, participants performed a same-different melody comparison task. During an 8-s retention interval, interference tasks were introduced to suppress articulatory rehearsal, attentional refreshing, or both. In Experiment 1, only the conditions that featured articulatory suppression resulted in worse memory performance than in a control condition, and the suppression of both attentional refreshing and articulatory rehearsal concurrently did not impair memory more than articulatory suppression alone. Experiment 2 reproduced these findings and also confirmed that the locus of interference was articulatory and not auditory (i.e., the interference was not attributable to the sound of participants' own voices during articulatory suppression). Both experiments suggested that articulatory rehearsal played a role in the maintenance of melodies in memory, whereas attentional refreshing did not. We discuss potential theoretical implications regarding the mechanisms used for the rehearsal of nonverbal sounds in working memory.

Refresher Course on Animal Behaviour

Indian Academy of Sciences (India)

an insect, echolocation and foraging behaviour of bats, and human circadian rhythms. The Course Director will be Dr G Marimuthu and Dr Sripathi Kandula will be the Course. Coordinator. Teachers who wish to participate in this Refresher Course should submit their brief curriculum vitae (including name, date of birth, sex, ...

Refresher Course in Plant Genetic Engineering

Indian Academy of Sciences (India)

A Refresher Course in Plant Genetic Engineering for postgraduate College ... that the teachers can perform the same set of experiments in their respective College/ ... research. The teachers are encouraged to add a note on their 'expectations' ...

Refreshing Refreshable Braille Displays.

Science.gov (United States)

Russomanno, Alexander; O'Modhrain, Sile; Gillespie, R Brent; Rodger, Matthew W M

2015-01-01

The increased access to books afforded to blind people via e-publishing has given them long-sought independence for both recreational and educational reading. In most cases, blind readers access materials using speech output. For some content such as highly technical texts, music, and graphics, speech is not an appropriate access modality as it does not promote deep understanding. Therefore blind braille readers often prefer electronic braille displays. But, these are prohibitively expensive. The search is on, therefore, for a low-cost refreshable display that would go beyond current technologies and deliver graphical content as well as text. And many solutions have been proposed, some of which reduce costs by restricting the number of characters that can be displayed, even down to a single braille cell. In this paper, we demonstrate that restricting tactile cues during braille reading leads to poorer performance in a letter recognition task. In particular, we show that lack of sliding contact between the fingertip and the braille reading surface results in more errors and that the number of errors increases as a function of presentation speed. These findings suggest that single cell displays which do not incorporate sliding contact are likely to be less effective for braille reading.

CatReg Software for Categorical Regression Analysis (Jul 2012)

Science.gov (United States)

CatReg is a computer program, written in the R (r-project.org">http://cran.r-project.org) programming language, to support the conduct of exposure-response analyses by toxicologists and health scientists. CatReg can be used to perform categorical regressi...

CatReg Software for Categorical Regression Analysis (Feb 2011)

Science.gov (United States)

CatReg is a computer program, written in the R (r-project.org">http://cran.r-project.org) programming language, to support the conduct of exposure-response analyses by toxicologists and health scientists. CatReg can be used to perform categorical regressi...

CatReg Software for Categorical Regression Analysis (Nov 2006)

Science.gov (United States)

CatReg is a computer program, written in the R (r-project.org">http://cran.r-project.org) programming language, to support the conduct of exposure-response analyses by toxicologists and health scientists. CatReg can be used to perform categorical regressi...

Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer.

Directory of Open Access Journals (Sweden)

Yutaka Naito

Full Text Available REG4, which encodes Reg IV protein, is a member of the calcium-dependent lectin superfamily and potent activator of the epidermal growth factor receptor/Akt/activator protein-1 signaling pathway. Several human cancers overexpress Reg IV, and Reg IV expression is associated with intestinal phenotype differentiation. However, regulation of REG4 transcription remains unclear. In the present study, we investigated whether CDX2 regulates Reg IV expression in gastric cancer (GC cells. Expression of Reg IV and CDX2 was analyzed by Western blot and quantitative reverse transcription-polymerase chain reaction in 9 GC cell lines and 2 colon cancer cell lines. The function of the 5'-flanking region of the REG4 gene was characterized by luciferase assay. In 9 GC cell lines, endogenous Reg IV and CDX2 expression were well correlated. Using an estrogen receptor-regulated form of CDX2, rapid induction of Reg IV expression was observed in HT-29 cells. Reporter gene assays revealed an important role in transcription for consensus CDX2 DNA binding elements in the 5'-flanking region of the REG4 gene. Chromatin immunoprecipitation assays showed that CDX2 binds directly to the 5'-flanking region of REG4. These results indicate that CDX2 protein directly regulates Reg IV expression.

Is refreshing in working memory impaired in older age? Evidence from the retro-cue paradigm.

Science.gov (United States)

Loaiza, Vanessa M; Souza, Alessandra S

2018-04-10

Impairments in refreshing have been suggested as one source of working memory (WM) deficits in older age. Retro-cues provide an important method of investigating this question: a retro-cue guides attention to one WM item, thereby arguably refreshing it and increasing its accessibility compared with a no-cue baseline. In contrast to the refreshing deficit hypothesis, intact retro-cue benefits have been found in older adults. Refreshing, however, is assumed to boost not one but several WM representations when sequentially applied to them. Hence, intact refreshing requires the flexible switching of attention among WM items. So far, it remains an open question whether older adults show this flexibility. Here, we investigated whether older adults can use multiple cues to sequentially refresh WM representations. Younger and older adults completed a continuous-color delayed-estimation task, in which the number of retro-cues (0, 1, or 2) presented during the retention interval was manipulated. The results showed a similar retro-cue benefit for younger and older adults, even in the two-cue condition in which participants had to switch attention between items to refresh representations in WM. These findings suggest that the capacity to use cues to refresh information in visual WM may be preserved with age. © 2018 New York Academy of Sciences.

The Global Redox Responding RegB/RegA Signal Transduction System Regulates the Genes Involved in Ferrous Iron and Inorganic Sulfur Compound Oxidation of the Acidophilic Acidithiobacillus ferrooxidans

Directory of Open Access Journals (Sweden)

Danielle Moinier

2017-07-01

Full Text Available The chemical attack of ore by ferric iron and/or sulfuric acid releases valuable metals. The products of these reactions are recycled by iron and sulfur oxidizing microorganisms. These acidophilic chemolithotrophic prokaryotes, among which Acidithiobacillus ferrooxidans, grow at the expense of the energy released from the oxidation of ferrous iron and/or inorganic sulfur compounds (ISCs. In At. ferrooxidans, it has been shown that the expression of the genes encoding the proteins involved in these respiratory pathways is dependent on the electron donor and that the genes involved in iron oxidation are expressed before those responsible for ISCs oxidation when both iron and sulfur are present. Since the redox potential increases during iron oxidation but remains stable during sulfur oxidation, we have put forward the hypothesis that the global redox responding two components system RegB/RegA is involved in this regulation. To understand the mechanism of this system and its role in the regulation of the aerobic respiratory pathways in At. ferrooxidans, the binding of different forms of RegA (DNA binding domain, wild-type, unphosphorylated and phosphorylated-like forms of RegA on the regulatory region of different genes/operons involved in ferrous iron and ISC oxidation has been analyzed. We have shown that the four RegA forms are able to bind specifically the upstream region of these genes. Interestingly, the phosphorylation of RegA did not change its affinity for its cognate DNA. The transcriptional start site of these genes/operons has been determined. In most cases, the RegA binding site(s was (were located upstream from the −35 (or −24 box suggesting that RegA does not interfere with the RNA polymerase binding. Based on the results presented in this report, the role of the RegB/RegA system in the regulation of the ferrous iron and ISC oxidation pathways in At. ferrooxidans is discussed.

The Global Redox Responding RegB/RegA Signal Transduction System Regulates the Genes Involved in Ferrous Iron and Inorganic Sulfur Compound Oxidation of the Acidophilic Acidithiobacillus ferrooxidans

Science.gov (United States)

Moinier, Danielle; Byrne, Deborah; Amouric, Agnès; Bonnefoy, Violaine

2017-01-01

The chemical attack of ore by ferric iron and/or sulfuric acid releases valuable metals. The products of these reactions are recycled by iron and sulfur oxidizing microorganisms. These acidophilic chemolithotrophic prokaryotes, among which Acidithiobacillus ferrooxidans, grow at the expense of the energy released from the oxidation of ferrous iron and/or inorganic sulfur compounds (ISCs). In At. ferrooxidans, it has been shown that the expression of the genes encoding the proteins involved in these respiratory pathways is dependent on the electron donor and that the genes involved in iron oxidation are expressed before those responsible for ISCs oxidation when both iron and sulfur are present. Since the redox potential increases during iron oxidation but remains stable during sulfur oxidation, we have put forward the hypothesis that the global redox responding two components system RegB/RegA is involved in this regulation. To understand the mechanism of this system and its role in the regulation of the aerobic respiratory pathways in At. ferrooxidans, the binding of different forms of RegA (DNA binding domain, wild-type, unphosphorylated and phosphorylated-like forms of RegA) on the regulatory region of different genes/operons involved in ferrous iron and ISC oxidation has been analyzed. We have shown that the four RegA forms are able to bind specifically the upstream region of these genes. Interestingly, the phosphorylation of RegA did not change its affinity for its cognate DNA. The transcriptional start site of these genes/operons has been determined. In most cases, the RegA binding site(s) was (were) located upstream from the −35 (or −24) box suggesting that RegA does not interfere with the RNA polymerase binding. Based on the results presented in this report, the role of the RegB/RegA system in the regulation of the ferrous iron and ISC oxidation pathways in At. ferrooxidans is discussed. PMID:28747899

The LANDFIRE Refresh strategy: updating the national dataset

Science.gov (United States)

Nelson, Kurtis J.; Connot, Joel A.; Peterson, Birgit E.; Martin, Charley

2013-01-01

The LANDFIRE Program provides comprehensive vegetation and fuel datasets for the entire United States. As with many large-scale ecological datasets, vegetation and landscape conditions must be updated periodically to account for disturbances, growth, and natural succession. The LANDFIRE Refresh effort was the first attempt to consistently update these products nationwide. It incorporated a combination of specific systematic improvements to the original LANDFIRE National data, remote sensing based disturbance detection methods, field collected disturbance information, vegetation growth and succession modeling, and vegetation transition processes. This resulted in the creation of two complete datasets for all 50 states: LANDFIRE Refresh 2001, which includes the systematic improvements, and LANDFIRE Refresh 2008, which includes the disturbance and succession updates to the vegetation and fuel data. The new datasets are comparable for studying landscape changes in vegetation type and structure over a decadal period, and provide the most recent characterization of fuel conditions across the country. The applicability of the new layers is discussed and the effects of using the new fuel datasets are demonstrated through a fire behavior modeling exercise using the 2011 Wallow Fire in eastern Arizona as an example.

Schedule-dependent interaction of paclitaxel (taxol[reg]) and irradiation in vitro

International Nuclear Information System (INIS)

Plasswilm, Ludwig; Cordes, Nils

1996-01-01

Purpose/Objective: The optimal dose and schedule of paclitaxel in combination with irradiation has not been determined yet. The aim of our study was first to compare the in vitro cytotoxicity and enhancement of radiation sensitization as a function of single dose versus fractionated paclitaxel administration. Secondly the cytotoxicity of the solvent cremophor/ethanol alone was evaluated and compared to the effect of Taxol[reg]. Materials and Methods: A fibroblast cell line (B14) in exponential growth phase with a doubling time of approximately 12 hours was used. Untreated cells and cells treated with phosphate buffered saline (PBS) were plated and used as control. Single dose and fractionated irradiation of 0 to 20 Gy (2.2 Gy/min) was delivered to the cells. Cytotoxicity of Taxol[reg] was examined at concentrations varied from 2 to 50 nmol compared to aliquots of cremophor/ethanol. Single dose (1x10 nmol) versus fractionated (2 nmol/day, day 1 to day 5) administration of Taxol[reg] was investigated. The combination of Taxol[reg] plus irradiation as single dose and fractionated administration was accomplished with 10 nmol Taxol[reg] on day 1 plus 10 Gy irradiation on day 1 (single dose administration) versus Taxol[reg], 2 nmol/day, day 1 to day 5, plus irradiation, 2 Gy/day, day 1 to day 5 (fractionated administration). Taxol[reg] administration was always performed for a 3 hour period with a 1-hour and 9-hour interval between Taxol[reg] administration and irradiation. All experiments were repeated in the same schedule with single dose and fractional administration of cremophor/ethanol. The clonogenic assay was applied to determine cell survival. Flow cytometric measurements were performed to study cell cycle DNA distribution. Results: Untreated controls and PBS treated cells (single dose and fractionated schedule) demonstrate an average plating efficiency of 93%. Single dose Taxol[reg] (1x10 nmol) administration show an average clonogenic survival of 88% (cremophor

Orimulsion{reg_sign} new generation: New commercial tests results

Energy Technology Data Exchange (ETDEWEB)

Marruffo, F.; Sarmiento, W.

2000-07-01

The new generation of Orimulsion{reg_sign} has been tested since September 1998 and was released to the market on January 1999 by PDVSA-Bitor. Main results from plants will be treated in detail within this paper. Boiler performance has been considerably improved by fuel switching. Operation changes could be summarized as follows: (1) Better furnace wall heat absorption; (2) Lower backend temperature; and (3) Lower sootblowing frequency. In Fuel Oil designed units, the new Orimulsion{reg_sign} firing current performance is similar to Fuel Oil, which indicates a similarity in combustion characteristics between these two fuels. This permits the switching to Orimulsion{reg_sign} in these units with only very minor modification. When compared to its predecessor, the new generation of Orimulsion{reg_sign} has proven to be a better product also from the environmental point of view. Due to its completely new designed surfactant package and its new architecture, the following results have consistently been shown: (1) Lower SO{sub 3} emissions; (2) Less CO production; and (3) Lower particulate levels.

Science Academies' Refresher Course in Quantum Mechanics

Indian Academy of Sciences (India)

IAS Admin

2013-02-28

Feb 28, 2013 ... A Refresher Course in Quantum Mechanics for college/university teachers ... The Course will cover the basic and advanced topics of Quantum ... Module 1:- Principles of Quantum Mechanics (with associated mathematics), ...

Science Academies' Refresher Course in Experimental Physics

Indian Academy of Sciences (India)

IAS Admin

2016-02-20

Students who wish to participate in this Refresher Course should submit their completed application form (in the prescribed format) by email or by post address (insaku2016@gmail.com),. (gulnoor.dar@gmail.com) or Course ...

Coupling of Community Land Model with RegCM4 for Indian Summer Monsoon Simulation

Science.gov (United States)

Maurya, R. K. S.; Sinha, P.; Mohanty, M. R.; Mohanty, U. C.

2017-11-01

Three land surface schemes available in the regional climate model RegCM4 have been examined to understand the coupling between land and atmosphere for simulation of the Indian summer monsoon rainfall. The RegCM4 is coupled with biosphere-atmosphere transfer scheme (BATS) and the National Center for Atmospheric Research (NCAR) Community Land Model versions 3.5, and 4.5 (CLM3.5 and CLM4.5, respectively) and model performance is evaluated for recent drought (2009) and normal (2011) monsoon years. The CLM4.5 has a more distinct category of surface and it is capable of representing better the land surface characteristics. National Centers for Environmental Prediction (NCEP) and Department of Energy (DOE) reanalysis version 2 (NNRP2) datasets are considered as driving force to conduct the experiments for the Indian monsoon region (30°E-120°E; 30°S-50°N). The NNRP2 and India Meteorological Department (IMD) gridded precipitation data are used for verification analysis. The results indicate that RegCM4 simulations with CLM4.5 (RegCM4-CLM4.5) and CLM3.5 (RegCM4-CLM3.5) surface temperature (at 2 ms) have very low warm biases ( 1 °C), while with BATS (RegCM4-BATS) has a cold bias of about 1-3 °C in peninsular India and some parts of central India. Warm bias in the RegCM4-BATS is observed over the Indo-Gangetic plain and northwest India and the bias is more for the deficit year as compared to the normal year. However, the warm (cold) bias is less in RegCM4-CLM4.5 than other schemes for both the deficit and normal years. The model-simulated maximum (minimum) surface temperature and sensible heat flux at the surface are positively (negatively) biased in all the schemes; however, the bias is higher in RegCM4-BATS and lower in RegCM4-CLM4.5 over India. All the land surface schemes overestimated the precipitation in peninsular India and underestimated in central parts of India for both the years; however, the biases are less in RegCM4-CLM4.5 and more in RegCM4-CLM3.5 and Reg

xdamp Version 3: An IDL reg-sign-based data and image manipulation program

International Nuclear Information System (INIS)

Ballard, W.P.

1998-05-01

The original DAMP (DAta Manipulation Program) was written by Mark Hedemann of Sandia National Laboratories and used the CA-DISSPLA trademark (available from Computer Associates International, Inc., Garden City, NY) graphics package as its engine. It was used to plot, modify, and otherwise manipulate the one-dimensional data waveforms (data vs. time) from a wide variety of accelerators. With the waning of CA-DISSPLA and the increasing popularity of Unix reg-sign-based workstations, a replacement was needed. This package uses the IDL reg-sign software, available from Research Systems Incorporated in Boulder, Colorado, as the engine, and creates a set of widgets to manipulate the data in a manner similar to the original DAMP and earlier versions of xdamp. IDL is currently supported on a wide variety of Unix platforms such as IBM reg-sign workstations, Hewlett Packard workstations, SUN reg-sign workstations, Microsoft reg-sign Windows trademark computers, Macintosh reg-sign computers and Digital Equipment Corporation VMS reg-sign and Alpha reg-sign systems. Thus, xdamp is portable across many platforms. The author has verified operation, albeit with some minor IDL bugs, on personal computers using Windows 95 and Windows NT; IBM Unix platforms; and DEC alpha and VMS systems; HP 9000/700 series workstations; and Macintosh computers, both regular and PowerPC trademark versions. Version 3 adds the capability to manipulate images to the original xdamp capabilities

Long-term semantic representations moderate the effect of attentional refreshing on episodic memory.

Science.gov (United States)

Loaiza, Vanessa M; Duperreault, Kayla A; Rhodes, Matthew G; McCabe, David P

2015-02-01

The McCabe effect (McCabe, Journal of Memory and Language 58:480-494, 2008) refers to an advantage in episodic memory (EM) retrieval for memoranda studied in complex span versus simple span tasks, particularly for memoranda presented in earlier serial positions. This finding has been attributed to the necessity to refresh memoranda during complex span tasks that, in turn, promotes content-context binding in working memory (WM). Several frameworks have conceptualized WM as being embedded in long-term memory. Thus, refreshing may be less efficient when memoranda are not well-established in long-term semantic memory (SM). To investigate this, we presented words and nonwords in simple and complex span trials in order to manipulate the long-term semantic representations of the memoranda with the requirement to refresh the memoranda during WM. A recognition test was administered that required participants to make a remember-know decision for each memorandum recognized as old. The results replicated the McCabe effect, but only for words, and the beneficial effect of refreshing opportunities was exclusive to recollection. These results extend previous research by indicating that the predictive relationship between WM refreshing and long-term EM is specific to recollection and, furthermore, moderated by representations in long-term SM. This supports the predictions of WM frameworks that espouse the importance of refreshing in content-context binding, but also those that view WM as being an activated subset of and, therefore, constrained by the contents of long-term memory.

Espécies de Gorybia Pascoe (Coleoptera, Cerambycidae, Piezocerini ocorrentes na Bolívia

Directory of Open Access Journals (Sweden)

Maria Helena M. Galileo

2013-03-01

Full Text Available Species of Gorybia Pascoe (Coleoptera, Cerambycidae, Piezocerini occurring in Bolivia. The genus Gorybia (Cerambycinae, Piezocerini consists of 45 described species with seven species recorded from Bolivia. Nine new species are described herein from Bolivia: G. abnormalis sp. nov.; G. alveolata sp. nov.; G. asyka sp. nov.; G. florida sp. nov.; G. inarmata sp. nov.; G. longithorax sp. nov.; G. guenda sp. nov.; G. tuberosa sp. nov. and G. wappesi sp. nov. A key to the species now known to occur in Bolivia is included.

Science Academies' Refresher Course on Theoretical Structural ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 22; Issue 8. Science Academies' Refresher Course on Theoretical Structural Geology, Crystallography, Mineralogy, Thermodynamics, Experimental Petrology and Theoretical Geophysics. Information and Announcements Volume 22 Issue 8 August 2017 ...

Stadis{reg_sign} 450 in Merox-sweetened jet fuels

Energy Technology Data Exchange (ETDEWEB)

Henry, C.P. [DuPont, Deepwater, NJ (United States)

1995-05-01

Stadis{reg_sign} 450 has been used in aviation fuels since 1983, and in many cases is the additive of choice due to conductivity retention of treated fuels during distribution, and other characteristics. In the past several years, manufacture of Shell ASA-3 (the other aviation-approved static dissipator additive) has been discontinued; current stores are being drawn down and for some refiners conversion from ASA-3 to Stadis{reg_sign} 450 is underway. In fuels sweetened by hydrogen-treating, Stadis{reg_sign} 450 performs very well and there are few reported difficulties. Chemically sweetened fuels sometimes contain trace materials not removed by the sweetening process. When treated with Stadis{reg_sign} 450 some of these fuels have exhibited two behaviors which are being addressed: in one case, the formation of a precipitate which disarmed coalescers; in several other cases, reduced conductivity response and loss of conductivity during storage coupled with unusually large effects on the microseparatometer water separation properties. In late 1992, a Coordinating Research Council (CRC) Panel on Coalescer Deactivation was formed to address these problems. The results of DuPont and CRC efforts are discussed, along with actions taken and underway to eliminate these problems.

Science Academies' Refresher Course in Mathematics

Indian Academy of Sciences (India)

IAS Admin

2015-06-14

Jun 14, 2015 ... A two-week Refresher Course in Mathematics will be organized during 1–14 June 2015 at School of Mathematics,. SMVD University, Katra, Jammu & Kashmir in association with School of Innovation and Community Develop- ment, SMVDU. The aim of the Course is to display the beauty of “complex ...

Science Academies' Refresher Course on Quantum Mechanics

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 21; Issue 7. Science Academies' Refresher Course on Quantum Mechanics. Information and Announcements Volume 21 Issue 7 July 2016 pp 669-670. Fulltext. Click here to view fulltext PDF. Permanent link:

Science Academies' Refresher Course in Developmental Biology

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 20; Issue 8. Science Academies' Refresher Course in Developmental Biology. Information and Announcements Volume 20 Issue 8 August 2015 pp 756-756. Fulltext. Click here to view fulltext PDF. Permanent link:

Ethnobotany of pru, a traditional Cuban refreshment

NARCIS (Netherlands)

Volpato, G.; Godínez, D.

2004-01-01

Gouania polygama (Jacq.) Urban, Smilax domingensis Willd., and Pimenta dioica Merr., are three species widely used within Cuban ethnobotanical traditions and practices. Pru is a traditional refreshment and medicinal drink produced by their decoction and fermentation with sugar. It is claimed to have

Critical safety parameters: The logical approach to refresher training

International Nuclear Information System (INIS)

Johnson, A.R.; Pilkington, W.; Turner, S.

1991-01-01

Nuclear power plant managers must ensure that control room staff are able to perform effectively. This is of particular importance through the longer term after initial authorization. Traditionally refresher training has been based on delivery of fragmented training packages typically derived from the initial authorization training programs. Various approaches have been taken to provide a more integrated refresher training program. However, methods such as job and task analysis and subject matter expert derived training have tended to develop without a focused clear overall training objective. The primary objective of all control room staff training is to ensure a proper and safe response to all plant transients. At the Point Lepreau Nuclear Plant, this has defined the Critical Safety Parameter based refresher training program. The overall objective of the Critical Safety Parameter training program is to ensure that control room staff can monitor and control a discrete set of plant parameters. Maintenance of the selected parameters within defined boundaries assures adequate cooling of the fuel and containment of radioactivity. Control room staff need to be able to reliably respond correctly to plant transients under potentially high stress conditions,. utilizing the essential knowledge and skills to deal with such transients. The inference is that the knowledge and skills must be limited to that which can be reliably recalled. This paper describes how the Point Lepreau Nuclear Plant has developed a refresher training program on the basis of a limited number of Critical Safety Parameters. Through this approach, it has been possible to define the essential set of knowledge and skills which ensures a correct response to plant transients

Seasonal distribution of Ochetina uniformis (Pascoe, 1881 adults in flooded riceDistribuição sazonal de adultos de Ochetina uniformis (Pascoe, 1881 em área de arroz irrigado

Directory of Open Access Journals (Sweden)

Alessandro Fiorentini

2013-03-01

Full Text Available A Ochetina uniformis (Pascoe, 1881 (Coleoptera: Erirhinidae populational survey was performed in the country of Santa Maria, Rio Grande do Sul State, in a commercial flooded rice field, from June 2005 to July 2006. A stratified sampling was used, with 90 sampling units of 0.25 m x 0.25 m, recorded every other week at the time of sampling. The reduction of the population of O. uniformis was observed from July to January. There were some areas without insects, and areas with a high populational density; with species occurring aggregated. Adults of O. uniformis remain concentrated on the levees of the field, representing 44% of the total collected. The remaining population is distributed from the levees inwards, reaching values between 12.9 and 15.1%. There were no adults of O. uniformis outside the cultivated area. Desenvolveu-se um levantamento populacional de Ochetina uniformis (Pascoe, 1881 (Coleoptera: Erirhinidae no município de Santa Maria, Rio Grande do Sul, em lavoura comercial de arroz irrigado, no período de junho de 2005 a julho de 2006. Foi utilizada a amostragem estratificada, com 90 unidades amostrais, de 0,25 m x 0,25 m, verificadas quinzenalmente, no momento da amostragem. A redução da população de O. uniformis foi encontrada de julho a janeiro. Foram verificadas áreas sem insetos e outras apresentaram alta densidade populacional com ocorrência agregada da espécie. Os adultos de O. uniformis permanecem concentrados junto as taipas da lavoura, representando 44% do total coletado. O restante da população encontra-se distribuído a partir da taipa da lavoura, para o seu interior, atingindo valores entre 12,9 e 15,1% do total. Não foi constatada a presença de adultos de O. uniformis no exterior da área cultivada.

30 CFR 46.8 - Annual refresher training.

Science.gov (United States)

2010-07-01

... affect the miner's health or safety. (c) Refresher training must also address other health and safety...; information about the physical and health hazards of chemicals in the miner's work area, the protective... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING...

xdamp Version 6.100: An IDL(reg sign)-based data and image manipulation program

International Nuclear Information System (INIS)

Ballard, William Parker

2012-01-01

The original DAMP (DAta Manipulation Program) was written by Mark Hedemann of Sandia National Laboratories and used the CA-DISSPLA(trademark) (available from Computer Associates International, Inc., Garden City, NY) graphics package as its engine. It was used to plot, modify, and otherwise manipulate the one-dimensional data waveforms (data vs. time) from a wide variety of accelerators. With the waning of CA-DISSPLA and the increasing popularity of Unix(reg sign)-based workstations, a replacement was needed. This package uses the IDL(reg sign) software, available from Research Systems Incorporated, a Xerox company, in Boulder, Colorado, as the engine, and creates a set of widgets to manipulate the data in a manner similar to the original DAMP and earlier versions of xdamp. IDL is currently supported on a wide variety of Unix platforms such as IBM(reg sign) workstations, Hewlett Packard workstations, SUN(reg sign) workstations, Microsoft(reg sign) Windows(trademark) computers, Macintosh(reg sign) computers and Digital Equipment Corporation VMS(reg sign) and Alpha(reg sign) systems. Thus, xdamp is portable across many platforms. We have verified operation, albeit with some minor IDL bugs, on personal computers using Windows 7 and Windows Vista; Unix platforms; and Macintosh computers. Version 6 is an update that uses the IDL Virtual Machine to resolve the need for licensing IDL.

76 FR 10403 - Hewlett Packard (HP), Global Product Development, Engineering Workstation Refresh Team, Working...

Science.gov (United States)

2011-02-24

...), Global Product Development, Engineering Workstation Refresh Team, Working On-Site at General Motors..., Non-Information Technology Business Development Team and Engineering Application Support Team, working... Hewlett Packard, Global Product Development, Engineering Workstation Refresh Team, working on-site at...

Syllabus. 5. Halley radiological refresher course. Chest, musculoskeleton, G. I. and abdomen, urinary tract

International Nuclear Information System (INIS)

Dalla Palma, L.

1996-01-01

This volume brings together the papers which 33 radiologists, chosen among the leading European experts, presented at the Halley Project 1996 Refresher Course. The project started out under the aegis of the European Association of Radiology in 1992 with the aim of fostering the advancement of radiolgy in various countries of Eastern Europe: Bulgaria, the Czech Republic, Slovakia, Hungary, Poland and Romania. It was possible to set up, in 1992, 1993, 1994 and 1995, four faculties of experts in uroradiology, gastrointestinal and abdominal radiology, chest radiology and skeletal radiology. These four faculties then gave a refresher course on the four radiological subspecialities in the six nations mentioned above. This year, the fifth in the activities, the event was celebrated by inviting all the 33 speakers who took part in the four previous refresher courses to participate in a single refresher course which would review the four subspecialities in such a way as to update progress in each branch to 1996. This volume gathers together all the 33 lectures presented at this 5th Halley Refresher Course. They focus on the most up-to-date issues in radiology of the chest, gastrointestinal tract, skeleton and urinary tract. (orig./VHE)

Refresher training as an important factor affecting safety of atomic energy utilization facilities

International Nuclear Information System (INIS)

Kapralov, E.

2005-01-01

Refresher training appears to be one of the most important factors, affecting safety of atomic energy utilization facilities. To provide up-to-date refresher training programs and courses TC NRS implements best training practice based on the actual and perspective Russian national and international norms, regulations, standards and recommendations. (author)

Refresher Course on Geomatic Applications for Sustainable Water ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 6. Refresher Course on Geomatic Applications for Sustainable Water Resources and Environment. Information and Announcements Volume 14 Issue 6 June 2009 pp 630-630 ...

Science Academies' Refresher Course on Modern Genetics ...

Indian Academy of Sciences (India)

IAS Admin

The objective of this Refresher Course is to give the participants a hands-on training on genetics and molecular biology techniques; and the theory behind them. A variety of teaching methods such as lectures, interaction with renowned resource persons, discussion and laboratory work shall facilitate the learning process.

Topical safety analysis report for the transportation of the NUHOMS{reg_sign} dry shielded canister. Volume 2

Energy Technology Data Exchange (ETDEWEB)

None

1993-08-01

A thermal analyses for the 10CFR71 normal conditions of . transport and hypothetical accident conditions is presented for the conceptual NUHOMS{reg_sign} Transportation Cask and NUHOMS{reg_sign}-24P DSC system. The purpose of the thermal analyses presented herein is to demonstrate that the conceptual NUHOMS{reg_sign} Transportation Cask with the NUHOMS{reg_sign}-24P DSC provides suitable heat dissipation to maintain the heat removal capacity of the loaded NUHOMS{reg_sign} Transportation Cask. The thermal analyses results show that the maximum temperatures and pressures of the NUHOMS{reg_sign} Transportation Cask and the NUHOMS{reg_sign}-24P DSC are within their allowable material temperature and pressure limits.

Science Academies Refresher Course on Traditional and Modern

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 17; Issue 9. Science Academies Refresher Course on Traditional and Modern Approaches in Plant Taxonomy'. Information and Announcements Volume 17 Issue 9 September 2012 pp 921-921 ...

Control of the dew point for refreshing ceiling

Energy Technology Data Exchange (ETDEWEB)

Abrach, R.; Nitz, T.

1996-03-01

The functioning of a refreshing ceiling, delivered in water, needs a global regulation which must take in consideration, the local, the building and its environment. Then efficiency and energy and investments economy are optimized. 11 figs., 3 tabs.

Science Academies' Refresher Course in Experimental Physics

Indian Academy of Sciences (India)

2017-12-18

Dec 18, 2017 ... laws and principles and yield reasonably accurate results. The Refresher Course is jointly spon- sored by the Indian Academy of Sciences, ... Selected participants will be provided local hospitality during the Course in addition to course material. Outstation participants will be given three-tier A/c train fare.

Science Academies' Refresher Course in Experimental Physics

Indian Academy of Sciences (India)

2017-12-18

Dec 18, 2017 ... A Refresher Course in Experimental Physics will be held at the Department of Physics, Panjab. University, Chandigarh held from 18 December 2017 to 2 January 2018 for the benefit of faculty involved in teaching undergraduate and postgraduate courses. The Course aims to familiarize the teachers with a ...

Identification of RegIV as a novel GLI1 target gene in human pancreatic cancer.

Directory of Open Access Journals (Sweden)

Feng Wang

2011-04-01

Full Text Available GLI1 is the key transcriptional factor in the Hedgehog signaling pathway in pancreatic cancer. RegIV is associated with regeneration, and cell growth, survival, adhesion and resistance to apoptosis. We aimed to study RegIV expression in pancreatic cancer and its relationship to GLI1.GLI1 and RegIV expression were evaluated in tumor tissue and adjacent normal tissues of pancreatic cancer patients and 5 pancreatic cancer cell lines by qRT-PCR, Western blot, and immunohistochemistry (IHC, and the correlation between them. The GLI1-shRNA lentiviral vector was constructed and transfected into PANC-1, and lentiviral vector containing the GLI1 expression sequence was constructed and transfected into BxPC-3. GLI1 and RegIV expression were evaluated by qRT-PCR and Western blot. Finally we demonstrated RegIV to be the target of GLI1 by chromatin immunoprecipitation (CHIP and electrophoretic mobility shift assays (EMSA.The results of IHC and qRT-PCR showed that RegIV and GLI1 expression was higher in pancreatic cancer tissues versus adjacent normal tissues (p<0.001. RegIV expression correlated with GLI1 expression in these tissues (R = 0.795, p<0.0001. These results were verified for protein (R = 0.939, p = 0.018 and mRNA expression (R = 0.959, p = 0.011 in 5 pancreatic cancer cell lines. RegIV mRNA and protein expression was decreased (94.7±0.3%, 84.1±0.5%; respectively when GLI1 was knocked down (82.1±3.2%, 76.7±2.2%; respectively by the RNAi technique. GLI1 overexpression in mRNA and protein level (924.5±5.3%, 362.1±3.5%; respectively induced RegIV overexpression (729.1±4.3%, 339.0±3.7%; respectively. Moreover, CHIP and EMSA assays showed GLI1 protein bound to RegIV promotor regions (GATCATCCA in pancreatic cancer cells.GLI1 promotes RegIV transcription by binding to the RegIV gene promoter in pancreatic cancer.

Sixty-first Science Academies' Refresher Course in Experimental ...

Indian Academy of Sciences (India)

IAS Admin

A Refresher Course in Experimental Physics will be held at the Department of Physics, School of ... With the aid of a low cost kit developed by ... highly successful and the experiments have been included in 80 institutions including universities,.

75 FR 54226 - Proposed Collection; Comment Request for Notice 98-52 and REG-108639-99

Science.gov (United States)

2010-09-03

... Notice 98-52 and REG- 108639-99 AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and... proposed rulemaking, REG-108639-99, Retirement Plans; Cash or Deferred Arrangements Under Section 401(k.... Regulation Project Number: REG-108639-99. Abstract: This notice provides guidance to plan administrators...

The effects of refreshing and elaboration on working memory performance, and their contributions to long-term memory formation.

Science.gov (United States)

Bartsch, Lea M; Singmann, Henrik; Oberauer, Klaus

2018-03-19

Refreshing and elaboration are cognitive processes assumed to underlie verbal working-memory maintenance and assumed to support long-term memory formation. Whereas refreshing refers to the attentional focussing on representations, elaboration refers to linking representations in working memory into existing semantic networks. We measured the impact of instructed refreshing and elaboration on working and long-term memory separately, and investigated to what extent both processes are distinct in their contributions to working as well as long-term memory. Compared with a no-processing baseline, immediate memory was improved by repeating the items, but not by refreshing them. There was no credible effect of elaboration on working memory, except when items were repeated at the same time. Long-term memory benefited from elaboration, but not from refreshing the words. The results replicate the long-term memory benefit for elaboration, but do not support its beneficial role for working memory. Further, refreshing preserves immediate memory, but does not improve it beyond the level achieved without any processing.

Science Academies' Refresher Course on Hydrology of Floods

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 22; Issue 10. Science Academies' Refresher Course on Hydrology of Floods. Information and Announcements Volume 22 Issue 10 October 2017 pp 978-978. Fulltext. Click here to view fulltext PDF. Permanent link:

Refresher Course on Mountain Hydrology and Climate Change

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 21; Issue 1. Refresher Course on Mountain Hydrology and Climate Change. Information and Announcements Volume 21 Issue 1 January 2016 pp 106-107. Fulltext. Click here to view fulltext PDF. Permanent link:

Characterization of a pneumatic balloon actuator for use in refreshable Braille displays.

Science.gov (United States)

Fan, Richard E; Feinman, Adam M; Wottawa, Christopher; King, Chih-Hung; Franco, Miguel L; Dutson, Erik P; Grundfest, Warren S; Culjat, Martin O

2009-01-01

Many existing refreshable Braille display technologies are costly or lack robust performance. A process has been developed to fabricate consistent and reliable pneumatic balloon actuators at low material cost, using a novel manufacturing process. This technique has been adapted for use in refreshable Braille displays that feature low power consumption, ease of manufacture and small form factor. A prototype refreshable cell, conforming to American Braille standards, was developed and tested. The cell was fabricated from molded PDMS to form balloon actuators with a spin-coated silicone film, and fast pneumatic driving elements and an electronic control system were developed to drive the Braille dots. Perceptual testing was performed to determine the feasibility of the approach using a single blind human subject. The subject was able to detect randomized Braille letters rapidly generated by the actuator with 100% character detection accuracy.

Science Academies' Refresher Course in Experimental Physics

Indian Academy of Sciences (India)

IAS Admin

The Course is particularly aimed at teachers (from University and Colleges in and around Mizoram, Aizawl) teaching at UG/PG level. College/University teachers having at least a Master's degree in Physics are eligible to apply. The UGC has also approved of 2-week Refresher Courses of good standing for promotion of ...

Waste Generation Overview Refresher, Course 21464

Energy Technology Data Exchange (ETDEWEB)

Simpson, Lewis Edward [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2016-12-13

This course, Waste Generation Overview Refresher (COURSE 21464), provides an overview of federal and state waste management regulations, as well as Los Alamos National Laboratory (LANL) policies and procedures for waste management operations. The course covers the activities involved in the cradle-to- grave waste management process and focuses on waste characterization, waste compatibility determinations and classification, and the storage requirements for temporary waste accumulation areas at LANL.

Fifty-Eighth Refresher Course in Experimental Physics

Indian Academy of Sciences (India)

IAS Admin

the MSc level. Refresher Courses in Experimental Physics held so far have been highly successful and the experiments have been included in the curricula of several universities in the South. Over one hundred kits have been sold and are used in universities and institutions in the country. The total number of seats in the ...

Science Academies Refresher Course on Traditional and Modern ...

Indian Academy of Sciences (India)

Admin

The National Academy of Sciences, India, Allahabad. In collaboration with. Botanical Garden & Herbarium, University of Agricultural Sciences, Bangalore from 15 to 29 November. 2012. A Refresher Course on Traditional and Modern Approaches in Plant Taxonomy for postgraduate college/university teachers and research ...

Improvements to TAO Ocean Observations as a Result of Refresh Technology

Science.gov (United States)

Grissom, K.; Petraitis, D. C.; Pounder, D.

2016-02-01

The Tropical Atmosphere Ocean (TAO) array has been a major observational component of El Nino Southern Oscillation (ENSO) and climate prediction research since its completion in 1994 by NOAA's Pacific Marine Environmental Laboratory (PMEL). In 2005 operational responsibility and control of the TAO array was transitioned from PMEL to the National Data Buoy Center (NDBC). As part of the transition, a project for TAO Technology Refresh was developed to address equipment obsolescence and the need for higher data throughput in real-time. Completed in 2014, the "TAO Refresh" array has met the requirements of the NOAA transition plan and added new capabilities and value. These new capabilities include a reduced latency of data and increased real-time resolution from one observation per sensor each day to 144+ observations per sensor each day. Also, improvements in NDBC data management practices resulted in the development of a new TAO Automated Statistical Quality-control (TASQ) system that provides a real-time automated quality-control method based upon 20 years of historical data. In addition, an active method for gathering actionable evidence and combating vandalism was achieved through the installation of cameras on TAO buoys. With these enhanced capabilities, the TAO Refresh array is better positioned to support timely analyses of the diurnal cycle and high frequency weather phenomena that affect climate. An added benefit of the Refresh technology is the reduced sampling error due to the temporal averaging. For example, during a recent week long vandalism event at a Refresh buoy we have found an average error of 0.24°C (±0.17) in the subsurface temperature daily average, with the maximum error of 0.67°C. Historically, due to the limitations of real-time communications, these errors were masked within the daily average. However, with today's satellite system we can retrieve the full-resolution time series in real-time and improve the quality of our data.

Reg Gene Expression in Periosteum after Fracture and Its In Vitro Induction Triggered by IL-6

Directory of Open Access Journals (Sweden)

Yasuaki Tohma

2017-10-01

Full Text Available The periosteum is a thin membrane that surrounds the outer surface of bones and participates in fracture healing. However, the molecular signals that trigger/initiate the periosteal reaction are not well established. We fractured the rat femoral bone at the diaphysis and fixed it with an intramedullary inserted wire, and the expression of regenerating gene (Reg I, which encodes a tissue regeneration/growth factor, was analyzed. Neither bone/marrow nor muscle showed Reg I gene expression before or after the fracture. By contrast, the periosteum showed an elevated expression after the fracture, thereby confirming the localization of Reg I expression exclusively in the periosteum around the fractured areas. Expression of the Reg family increased after the fracture, followed by a decrease to basal levels by six weeks, when the fracture had almost healed. In vitro cultures of periosteal cells showed no Reg I expression, but the addition of IL-6 significantly induced Reg I gene expression. The addition of IL-6 also increased the cell number and reduced pro-apoptotic gene expression of Bim. The increased cell proliferation and reduction in Bim gene expression were abolished by transfection with Reg I siRNA, indicating that these IL-6-dependent effects require the Reg I gene expression. These results indicate the involvement of the IL-6/Reg pathway in the osteogenic response of the periosteum, which leads to fracture repair.

Improved Retention of Chest Compression Psychomotor Skills With Brief "Rolling Refresher" Training.

Science.gov (United States)

Niles, Dana E; Nishisaki, Akira; Sutton, Robert M; Elci, Okan U; Meaney, Peter A; OʼConnor, Kathleen A; Leffelman, Jessica; Kramer-Johansen, Jo; Berg, Robert A; Nadkarni, Vinay

2017-08-01

High-quality cardiopulmonary resuscitation (CPR) is critical to improve survival from cardiac arrest. However, cardiopulmonary resuscitation knowledge and psychomotor skill proficiency are transient. We hypothesized that brief, in situ refresher training will improve chest compression (CC) psychomotor skill retention for bedside providers. Nurses completed a baseline skill evaluation of CC quality 6 months after traditional basic life support recertification. Data collected using ResusciAnne with SkillReporter included the following: CC depth, rate, complete release, and correct hand position. Total compliance was defined as 100% CC with depth of 50 mm or greater, rate of 100/min or greater, and more than 90% complete release. After the baseline evaluation, the subjects completed "Rolling Refresher" (RR) CC psychomotor training using audiovisual feedback every 2 to 3 months for 12 months until 30 seconds of CCs fulfilling total compliance criteria was achieved. Chest compression quality evaluations were repeated twice ("RR 6 month" and "RR 12 month" evaluation) after implementation of RR program. Thirty-seven providers enrolled and completed the baseline evaluation. Mean depth was 36.3 (9.7) mm, and 8% met criteria for depth, 35% for rate, and 5% for total compliance. After RRs were implemented, CC quality improved significantly at RR 6-month evaluation: odds ratio for meeting criteria were the following: depth of 35.1 (95% confidence interval = 2.5496, P = 0.009) and total compliance of 22.3 (95% confidence interval = 2.1239, P = 0.010). There was no difference in CC quality at RR 12-month versus RR 6-month evaluation. Retention of CC psychomotor skill quality is limited to 6 months after traditional basic life support recertification. Rolling Refresher CC training can significantly improve retention of CC psychomotor skills. Whether CC skills are improved, maintained, or deteriorate after 12 months of Refresher training and optimal frequency of Refreshers is

360 year temperature and precipitation record for the Pasco Basin derived from tree-ring data

International Nuclear Information System (INIS)

Cropper, J.P.; Fritts, H.C.

1986-08-01

Dendroclimatology, the study of past climatic variations by means of tree-ring analysis, is used to produce estimates of seasonal and annual temperature and precipitation from the 17th through 20th centuries. In this study these estimates, reconstructions, are derived in five different ways for regions that each include the Pasco Basin of south central Washington. The best of five sets of results were selected, based on the verification of the reconstructions with independent instrumental data. The reconstructed annual temperature of the Pasco Basin for the last three centuries was on the average 0.17 degrees Fahrenheit higher and had a standard deviation which was 4% larger than for the 20th century. The greatest reconstructed difference in the average temperature was in winter and the greatest reconstructed difference in the variance (standard deviation) was reconstructed in autumn. The average annual precipitation reconstructed for 1602 to 1900 was 0.32 inches higher than it has been in the 20th century. The change in average and standard deviation of reconstructed precipitation was greatest in autumn. Both the seasonal and annual reconstructions for temperature and precipitation exhibit large and persistent variations from the mean which are often most pronounced in the 17th century. Droughts were more common starting with the last half of the 17th century, with values that sometimes exceeded the 20th-century maximum amounts and duration. While there are some similarities among the four seasons and two variables, many differences between the seasonal reconstructions exist. 28 refs., 6 figs., 6 tabs

[Effectiveness and practicality of an internet-based asthma refresher course for children and adolescents].

Science.gov (United States)

Schmidt, A; Greuter, T; Möller, A; Steiß, J O

2014-04-01

The effectiveness and practicality of the "Luftikids" (www.luftikids.de) structured, internet-based asthma refresher course was evaluated in a pilot study with 53 patients (ages 8 - 14 years). All patients had previously participated in either an inpatient or outpatient asthma education program. This prospective study examined the effect of a 4-week refresher course on parameters such as asthma symptoms (coughing, dyspnea), the number of unscheduled doctor's visits, use of on-demand medications, number of days absent from school, and asthma monitoring using the Asthma Control Questionnaire (ACQ) and lung function tests. The duration of program use and the number of logins was used to investigate acceptance of the game format. Data were collected at the beginning of the study and at 4 - 6 months after the end of the online refresher course. Significant changes were shown with regard to the decrease in intensity of asthma symptoms such as coughing (p = 0.001) and dyspnea (p = 0.007), reduction in the number of unscheduled doctor's visits (p = 0.005), the use of on-demand medications (4.0 ± 6.5 vs. 1.5 ± 4.9, p = children and adolescents derived "much" to "very much" benefit. Only 7.5% reported no effect. Participation in the "Luftikids" internet-based asthma refresher course resulted in fewer asthma symptoms, a decrease in unscheduled doctor's visits, reduction in the use of on-demand medications, decrease in the number of days absent from school, and improved asthma knowledge. No effect in lung function could be demonstrated. The results support the effectiveness and good acceptance of an outpatient, internet-based asthma refresher course. Young asthma patients in particular can succeed with and be motivated by this form of refresher course. © Georg Thieme Verlag KG Stuttgart · New York.

Adaptive choice between articulatory rehearsal and attentional refreshing in verbal working memory.

Science.gov (United States)

Camos, Valérie; Mora, Gerome; Oberauer, Klaus

2011-02-01

Because both articulatory rehearsal and attentional refreshing aid in the maintenance of verbal information in the short term, the present study evaluated the adaptive use of these mechanisms, using a complex span paradigm. In Experiment 1, the phonological similarity of memory list words and the attentional demand of concurrent processing were manipulated. As was predicted, a phonological similarity effect (PSE) appeared only when the concurrent task was attention demanding, thus impairing the use of refreshing and encouraging rehearsal. To verify that PSE indicates the use of rehearsal, participants were instructed to use one of the two mechanisms in Experiments 2 and 3. In accordance wih Experiment 1, the PSE was observed only under rehearsal. Thus, adults could adaptively choose between the two mechanisms. When remembering phonologically confusable materials, they prefer refreshing in order to reduce the impact of phonological characteristics. When available attention is reduced, they favor a less attention-demanding mechanism, rehearsal.

Information and Announcements Refresher Course on Frontiers in ...

Indian Academy of Sciences (India)

This Refresher Course for teachers from graduate and post-graduate colleges and univer- sity departments aims at providing a unified view of modern inorganic chemistry and hands-on experience in doing a few selected exciting laboratory experiments. Emphasis will be given to unique interdisciplinary nature of inorganic ...

Science Academies' Refresher Course in Developmental Biology 16 ...

Indian Academy of Sciences (India)

IAS Admin

The objectives of this Refresher Course are to update the participants about the advances in the field of Developmental Biology; various small animal models used and give hands-on training on some modern biotechnological practices. A variety of teaching methods like lectures, discussion and laboratory work shall ...

Science Academies' Refresher Course on Modern and Ancient ...

Indian Academy of Sciences (India)

Sengupta, AvH Fellow, F.A.Sc., F.N.A (pulaksg@gmail.com). It may be noted that UGC regulations include Refresher Courses in API scores for career advancement. Applications are invited from teachers with experience in teaching undergraduate and postgraduate courses in Earth Science. Motivated research scholars ...

Reg proteins and their roles in inflammation and cancer of the human digestive system.

Science.gov (United States)

Zhao, Jie; Wang, Jingyu; Wang, Hao; Lai, Maode

2013-01-01

The regenerating gene (Reg) family is a group of small molecules that includes four members found in various species, although only three are found in human tissues. Their expression is stimulated by certain growth factors or cytokines. The Reg family plays different roles in proliferation, migration, and anti-apoptosis through activating different signaling pathways. Their dysexpression is closely associated with a number of human conditions and diseases such as inflammation and cancer, especially in the human digestive system. Clinically, upregulation of Reg proteins is usually demonstrated in histological sections and sera from cancer patients. Therefore, Reg proteins can predict the progression and prognosis of cancers, especially those of the digestive tract, and can also act as diagnostic markers and therapeutic targets.

Refresher Course in Theoretical Physics at St. Stephen's College ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 7; Issue 5. Refresher Course in Theoretical Physics at St. Stephen's College University of Delhi, Delhi. Information and Announcements Volume 7 Issue 5 May 2002 pp 103-103 ...

RegPredict: an integrated system for regulon inference in prokaryotes by comparative genomics approach

Energy Technology Data Exchange (ETDEWEB)

Novichkov, Pavel S.; Rodionov, Dmitry A.; Stavrovskaya, Elena D.; Novichkova, Elena S.; Kazakov, Alexey E.; Gelfand, Mikhail S.; Arkin, Adam P.; Mironov, Andrey A.; Dubchak, Inna

2010-05-26

RegPredict web server is designed to provide comparative genomics tools for reconstruction and analysis of microbial regulons using comparative genomics approach. The server allows the user to rapidly generate reference sets of regulons and regulatory motif profiles in a group of prokaryotic genomes. The new concept of a cluster of co-regulated orthologous operons allows the user to distribute the analysis of large regulons and to perform the comparative analysis of multiple clusters independently. Two major workflows currently implemented in RegPredict are: (i) regulon reconstruction for a known regulatory motif and (ii) ab initio inference of a novel regulon using several scenarios for the generation of starting gene sets. RegPredict provides a comprehensive collection of manually curated positional weight matrices of regulatory motifs. It is based on genomic sequences, ortholog and operon predictions from the MicrobesOnline. An interactive web interface of RegPredict integrates and presents diverse genomic and functional information about the candidate regulon members from several web resources. RegPredict is freely accessible at http://regpredict.lbl.gov.

The labelling of Nanocoll[reg] with [111In] for dual-isotope scanning

International Nuclear Information System (INIS)

Mitterhauser, Markus; Wadsak, Wolfgang; Key Mien, Leonhard-; Eidherr, Harald; Roka, Sebastian; Zettinig, Georg; Angelberger, Peter; Viernstein, Helmut; Kletter, Kurt; Dudczak, Robert

2003-01-01

Visualization and biopsy of sentinel lymph nodes play an important role in planning and controlling the therapy of breast cancer. Hitherto two methods--scintigraphy or gamma probe detection after injection of [ 99m Tc]-nanocolloids and visual detection after injection of patent blue dye--are used routinely. There are no conclusive publications elucidating such important parameters as injection site, injection method and colloidal parameters. The present work aims to label Nanocoll[reg] with [ 111 In] to provide an alternative method, a simultaneous one-compound dual-isotope application. Methods: [ 111 In]-Indiumchloride was buffered with acetate and transferred to the nanocolloid. The colloid labelling reaction was complete after 30 min and filtrated through 100 nm Nuclepore[reg] filters. Results: Incorporation yield of [ 111 In]-Indium into the nanocolloid was nearly quantitative, the step associated with the major loss of activity was the particle sizing with a mean yield of 55%. Conclusion: The presented method allows for the routine supply of [ 111 In]-nanocolloids. Size-filtered [ 111 In]-Nanocoll[reg] shows the same particle size range as [ 99m Tc]-Nanocoll[reg

Fourth Refresher Course in Materials Preparation and Measurement ...

Indian Academy of Sciences (India)

IAS Admin

2014-12-20

Dec 20, 2014 ... Refresher courses in Experimental Physics conducted by R Srinivasan have been very successful. Total number of seats in the Course will be about 25. The Course is essentially meant for teachers in universities and colleges, teaching Physics or. Materials Science. A few students studying MSc-I Physics ...

Science Academies' 82nd Refresher Course on Experimental Physics

Indian Academy of Sciences (India)

IAS Admin

A Refresher Course in Experimental Physics will be held at Department of Physics, ... the participants to gain hands on experience with set of new experiments developed as a low cost kit by the Indian Academy of Sciences, Bangalore, Indian ...

从FinTech到RegTech

Institute of Scientific and Technical Information of China (English)

孙国峰[1,2

2017-01-01

本文分析FinTech（金融科技）监管的必要性，并介绍了FinTech监管的国际经验，在此基础上提出了我国可以探索将人工智能应用于金融监管，即以RegTech（监管科技）应对FinTech的建议。

Science Academies Seventy-Fifth Refresher Course in Experimental ...

Indian Academy of Sciences (India)

IAS Admin

A Refresher Course in Experimental Physics will be held at Goa University, Goa from 10 to 25 May 2016 for the benefit of faculty involved in teaching undergraduate and postgraduate courses. Participants in this course will gain hands on experience with about twenty five out of forty experiments, with a low cost kit ...

Refresher Course on Lasers and Applications in Chemical Processes

Indian Academy of Sciences (India)

lasers, modes of laser, mode locking, Q-switching, nonlinear optical materials, electro- optic and magneto-optic materials. It will also include laboratory demonstration experi- ments in selected areas of fluorescence and pump-probe methods. Teachers who wish to participate in the Refresher Course should submit their brief.

Expression and Significance of the HIP/PAP and RegIIIγ Antimicrobial Peptides during Mammalian Urinary Tract Infection.

Directory of Open Access Journals (Sweden)

John David Spencer

Full Text Available Recent evidence indicates that antimicrobial peptides (AMPs serve key roles in defending the urinary tract against invading uropathogens. To date, the individual contribution of AMPs to urinary tract host defense is not well defined. In this study, we identified Regenerating islet-derived 3 gamma (RegIIIγ as the most transcriptionally up-regulated AMP in murine bladder transcriptomes following uropathogenic Escherichia coli (UPEC infection. We confirmed induction of RegIIIγ mRNA during cystitis and pyelonephritis by quantitative RT-PCR. Immunoblotting demonstrates increased bladder and urinary RegIIIγ protein levels following UPEC infection. Immunostaining localizes RegIIIγ protein to urothelial cells of infected bladders and kidneys. Human patients with UTI have increased urine concentrations of the orthologous Hepatocarcinoma-Intestine-Pancreas / Pancreatitis Associated Protein (HIP/PAP compared to healthy controls. Recombinant RegIIIγ protein does not demonstrate bactericidal activity toward UPEC in vitro, but does kill Staphylococcus saprophyticus in a dose-dependent manner. Kidney and bladder tissue from RegIIIγ knockout mice and wild-type mice contain comparable bacterial burden following UPEC and Gram-positive UTI. Our results demonstrate that RegIIIγ and HIP/PAP expression is induced during human and murine UTI. However, their specific function in the urinary tract remains uncertain.

Expression and Significance of the HIP/PAP and RegIIIγ Antimicrobial Peptides during Mammalian Urinary Tract Infection

Science.gov (United States)

Spencer, John David; Jackson, Ashley R.; Li, Birong; Ching, Christina B.; Vonau, Martin; Easterling, Robert S.; Schwaderer, Andrew L.; McHugh, Kirk M.; Becknell, Brian

2015-01-01

Recent evidence indicates that antimicrobial peptides (AMPs) serve key roles in defending the urinary tract against invading uropathogens. To date, the individual contribution of AMPs to urinary tract host defense is not well defined. In this study, we identified Regenerating islet-derived 3 gamma (RegIIIγ) as the most transcriptionally up-regulated AMP in murine bladder transcriptomes following uropathogenic Escherichia coli (UPEC) infection. We confirmed induction of RegIIIγ mRNA during cystitis and pyelonephritis by quantitative RT-PCR. Immunoblotting demonstrates increased bladder and urinary RegIIIγ protein levels following UPEC infection. Immunostaining localizes RegIIIγ protein to urothelial cells of infected bladders and kidneys. Human patients with UTI have increased urine concentrations of the orthologous Hepatocarcinoma-Intestine-Pancreas / Pancreatitis Associated Protein (HIP/PAP) compared to healthy controls. Recombinant RegIIIγ protein does not demonstrate bactericidal activity toward UPEC in vitro, but does kill Staphylococcus saprophyticus in a dose-dependent manner. Kidney and bladder tissue from RegIIIγ knockout mice and wild-type mice contain comparable bacterial burden following UPEC and Gram-positive UTI. Our results demonstrate that RegIIIγ and HIP/PAP expression is induced during human and murine UTI. However, their specific function in the urinary tract remains uncertain. PMID:26658437

An evaluation of a refresher training intervention for HIV lay ...

African Journals Online (AJOL)

Charles Msisuka a , Ikuma Nozaki b i-nozaki@it.ncgm.go.jpinozaki@hsph.harvard.edu, Kazuhiro Kakimoto c , Motoko Seko d & Mercy M S Ulaya e

Twenty-five lay counsellors were selected by District Health Office and participated in ... The workshop included: the opening, a pre-training exercise, lectures on quality ... We conclude that the refresher training was effective for improving the ...

Science Academies' 83rd Refresher Course on Experimental Physics

Indian Academy of Sciences (India)

IAS Admin

A Science Academies' Refresher Course in “Experimental Physics” will be held in the Department of Physics,. College of Arts, Science and Humanities, Mody University of Science and Technology, Lakshmangarh, District. Sikar (Rajasthan), from 29 December 2016 to 13 January 2017 for the benefit of faculty involved in ...

Japanese Non Resident Language Refresher Course; 210 Hour Course.

Science.gov (United States)

Defense Language Inst., Washington, DC.

This military intelligence unit refresher course in Japanese is designed for 210 hours of audiolingual instruction. The materials, prepared by the Defense Language Institute, are intended for students with considerable intensive training in spoken and written Japanese who are preparing for a military language assignment. [Not available in hard…

Refresher Course in Applications of Quantum Mechanics to 'Atoms ...

Indian Academy of Sciences (India)

IAS Admin

A Refresher Course in Applications of Quantum Mechanics to 'Atoms, Molecules and Radiation' will be held at the Indian Academy of Sciences, Bangalore from December 8 to 20. 2014. The Course is primarily aimed at teachers teaching quantum mechanics and/ or atomic and molecular physics at the UG / PG level.

Effects of Refresher Training on Job-Task Typewriting Performance.

Science.gov (United States)

Hagman, Joseph D.; Schendel, Joel D.

Two groups of 15 Administrative Specialists, 7lL Military Occupational Speciality (MOS), participated in four job-task refresher training sessions designed to enhance the typewriting of military correspondence. One group performed under a study training method which allowed use of a Correspondence Manual while arranging materials into the correct…

Science Academies' 93rd Refresher Course in Experimental Physics

Indian Academy of Sciences (India)

A Refresher Course in Experimental Physics will be held at the Department of Physics, Indian. Institute of Technology Patna, Bihta, India from November 07–22, 2017 for the benefit of faculty involved in teaching undergraduate and postgraduate courses. Participants in this course will gain hands-on experience with about ...

Science Academies' 93rd Refresher Course in Experimental Physics

Indian Academy of Sciences (India)

2017-09-30

Sep 30, 2017 ... A Refresher Course in Experimental Physics will be held at the Department of Physics, Indian. Institute of Technology Patna, Bihta, India from November 07–22, 2017 for the benefit of faculty involved in teaching undergraduate and postgraduate courses. Participants in this course will gain hands-on ...

Operator refresher training and requalification at Cernavoda NPP

International Nuclear Information System (INIS)

Timoftei, D.

2002-01-01

The paper presents the Operator's training program for refresher and requalification purposes, which were developed using the CANDU training full-scope simulator at Cernavoda NPP. First the purpose of both programs is described, and then more details on how these programs are delivered are given. The Refresher Training Program, part of the Operator Continuing Training Program, and the Requalification Training Program are periodically training given to the previously authorised operating personnel. The training and the evaluation are conducted both on an individual and on the team basis. Both programs are tailored according with Systematic Approach to Training concept. In addition to that the importance of the training on simulator arises from the fact that the training is mostly related to plant transients/accidents that in real life may never happens, but the operators should be always prepared for the worst. Continuing Training Program (CTP) applies to the authorized positions of Shift Supervisor (SS) and Control Room Operator (CRO) at CNE-PROD Cernavoda. Also, the program is establishing the criteria and the process, which will allow the authorised SS and CRO to maintain their authorised status. (author)

The influence of aging on attentional refreshing and articulatory rehearsal during working memory on later episodic memory performance.

Science.gov (United States)

Loaiza, Vanessa M; McCabe, David P

2013-01-01

We investigated age-related changes in two proposed mechanisms of maintenance in working memory, articulatory rehearsal, and attentional refreshing, by examining the consequences of manipulating the opportunity for each on delayed recall. Both experiments utilized modified operation span tasks to vary the opportunity for articulatory rehearsal (Experiment 1) and attentional refreshing opportunities (Experiment 2). In both experiments, episodic memory was tested for items that had been initially studied during the respective operation span task. Older adults' episodic memory benefited less from opportunities for refreshing than younger adults. In contrast, articulatory rehearsal opportunities did not influence episodic memory for either age group. The results suggest that attentional refreshing, and not articulatory rehearsal, is important during working memory in order to bind more accessible traces at later tests, which appears to be more deficient in older adults than younger adults.

The Influence of Age-Related Differences in Prior Knowledge and Attentional Refreshing Opportunities on Episodic Memory.

Science.gov (United States)

Loaiza, Vanessa M; Rhodes, Matthew G; Anglin, Julia

2015-09-01

The assumption that working memory (WM) is embedded within long-term memory suggests that the effectiveness of switching information between activated states in WM (i.e., attentional refreshing) may depend on whether that information is semantically relevant. Given that older adults often have greater general knowledge than younger adults, age-related deficits in episodic memory (EM) could be ameliorated by studying information that has existing semantic representations compared with unknown information. Younger and older adults completed a modified operation span task that varied the number of refreshing opportunities. The memoranda used were equally known to younger and older adults (neutral words; e.g., father), better known to older adults than younger adults (dated words; e.g., mirth), or unknown to both groups (unknown words; e.g., cobot). Results for immediate and delayed recall indicated an age-related improvement for dated memoranda and no age difference for unknown memoranda. Furthermore, refreshing opportunities predicted delayed recall of neutral memoranda more strongly for younger adults than older adults, whereas older adults' recall advantage for dated memoranda was explained by their prior knowledge and not refreshing opportunities. The results suggest that older adults' EM deficits could potentially be ameliorated by incorporating their superior knowledge to supplement relatively ineffective attentional refreshing in WM. © The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

An implementation of SAS reg-sign in an environmental information system

International Nuclear Information System (INIS)

James, T.; Zygmunt, B.C.

1994-01-01

This paper describes a software environmental database information system that uses SAS to process data and ORACLE reg-sign as the relational database management system (RDBMS). The hardware includes a network of UNIX-based servers and workstations. The relational database consists of large tables containing envionmental measurement data, as well as other smaller tables with reference, metadata and internal administrative information. The data come in a variety of formats and must be converted to conform to the system's standards. SAS/ACCESS reg-sign and PROC SQL are used extensively in the data processing

Magnetically-refreshable receptor platform structures for reusable nano-biosensor chips

International Nuclear Information System (INIS)

Yoo, Haneul; Cho, Dong-guk; Park, Juhun; Nam, Ki Wan; Cho, Young Tak; Chen, Xing; Hong, Seunghun; Lee, Dong Jun; Park, Jae Yeol

2016-01-01

We developed a magnetically-refreshable receptor platform structure which can be integrated with quite versatile nano-biosensor structures to build reusable nano-biosensor chips. This structure allows one to easily remove used receptor molecules from a biosensor surface and reuse the biosensor for repeated sensing operations. Using this structure, we demonstrated reusable immunofluorescence biosensors. Significantly, since our method allows one to place receptor molecules very close to a nano-biosensor surface, it can be utilized to build reusable carbon nanotube transistor-based biosensors which require receptor molecules within a Debye length from the sensor surface. Furthermore, we also show that a single sensor chip can be utilized to detect two different target molecules simply by replacing receptor molecules using our method. Since this method does not rely on any chemical reaction to refresh sensor chips, it can be utilized for versatile biosensor structures and virtually-general receptor molecular species. (paper)

RegTransBase - A Database Of Regulatory Sequences and Interactionsin a Wide Range of Prokaryotic Genomes

Energy Technology Data Exchange (ETDEWEB)

Kazakov, Alexei E.; Cipriano, Michael J.; Novichkov, Pavel S.; Minovitsky, Simon; Vinogradov, Dmitry V.; Arkin, Adam; Mironov, AndreyA.; Gelfand, Mikhail S.; Dubchak, Inna

2006-07-01

RegTransBase, a manually curated database of regulatoryinteractions in prokaryotes, captures the knowledge in publishedscientific literature using a controlled vocabulary. Although a number ofdatabases describing interactions between regulatory proteins and theirbinding sites are currently being maintained, they focus mostly on themodel organisms Escherichia coli and Bacillus subtilis, or are entirelycomputationally derived. RegTransBase describes a large number ofregulatory interactions reported in many organisms and contains varioustypes of experimental data, in particular: the activation or repressionof transcription by an identified direct regulator; determining thetranscriptional regulatory function of a protein (or RNA) directlybinding to DNA (RNA); mapping or prediction of binding site for aregulatory protein; characterization of regulatory mutations. Currently,the RegTransBase content is derived from about 3000 relevant articlesdescribing over 7000 experiments in relation to 128 microbes. It containsdata on the regulation of about 7500 genes and evidence for 6500interactions with 650 regulators. RegTransBase also contains manuallycreated position weight matrices (PWM) that can be used to identifycandidate regulatory sites in over 60 species. RegTransBase is availableat http://regtransbase.lbl.gov.

IMHEX{sup {reg_sign}} fuel cells progress toward commercialization

Energy Technology Data Exchange (ETDEWEB)

Scroppo, J.A.; Laurens, R.M.; Petraglia, V.J.

1995-12-31

The overall goal of M-C Power is the development and subsequent commercialization of Molten Carbonate Fuel Cell (MCFC) stacks. More specifically, MCFC`s Manifolded Heat Exchange (IMHEX{sup {reg_sign}}) plate design created by the Institute of Technology. In order to achieve the aforementioned goal, M-C Power assembled a formidable team of industry leaders. This group, refered to as the (IHMEX{sup {reg_sign}}) Team, has developed a strategy to move decisively through the stages of Technology Development and Product Design and Improvement through commercialization. This paper is to review the status of the overall commercialization program and activities. It will also provide an overview of the market entry product. Furthermore, we will evaluate the opportunities and benefits this product brings to a competitive power industry.

Stage-specific hypermutability of the regA locus of Volvox, a gene regulating the germ-soma dichotomy

International Nuclear Information System (INIS)

Kirk, D.L.; Baran, G.J.; Harper, J.F.; Huskey, R.J.; Huson, K.S.; Zagris, N.

1987-01-01

Mutation at the regA locus confers on somatic cells of Volvox (which otherwise undergo programmed death) ability to redifferentiate as reproductive cells. Stable mutations at the regA locus, but not at other loci, were induced at high frequency when embryos at one particular stage were exposed to either UV irradiation, novobiocin, nalidixic acid, bleomycin, 4-hydroxyaminoquinoline-1-oxide, 5-bromodeoxyuridine, or 5-fluorouracil. All treatments led to some mutations that were not expressed until the second generation after treatment. The sensitive period was after somatic and reproductive cells of the next generation had been set apart, but before they had undergone cytodifferentiation. Hypermutability occurs in presumptive reproductive cells (in which regA is normally not expressed) somewhat before regA normally acts in somatic cells. We postulate that hypermutability of regA in the reproductive cells at this time reflects a change of state that the locus undergoes as it is inactivated

Previsões climáticas sazonais sobre o Brasil: avaliação do RegCM3 aninhado no modelo global CPTEC/COLA Seasonal climatic forecast over Brazil: evaluation of the RegCM3 model nested to the CPTEC/COLA global model

Directory of Open Access Journals (Sweden)

Rubinei Dorneles Machado

2011-03-01

Full Text Available Este trabalho avalia o desempenho de previsões sazonais do modelo climático regional RegCM3, aninhado ao modelo global CPTEC/COLA. As previsões com o RegCM3 utilizaram 60 km de resolução horizontal num domínio que inclui grande parte da América do Sul. As previsões do RegCM3 e CPTEC/COLA foram avaliadas utilizando as análises de chuva e temperatura do ar do Climate Prediction Center (CPC e National Centers for Enviromental Prediction (NCEP, respectivamente. Entre maio de 2005 e julho de 2007, 27 previsões sazonais de chuva e temperatura do ar (exceto a temperatura do CPTEC/COLA, que possui 26 previsões foram avaliadas em três regiões do Brasil: Nordeste (NDE, Sudeste (SDE e Sul (SUL. As previsões do RegCM3 também foram comparadas com as climatologias das análises. De acordo com os índices estatísticos (bias, coeficiente de correlação, raiz quadrada do erro médio quadrático e coeficiente de eficiência, nas três regiões (NDE, SDE e SUL a chuva sazonal prevista pelo RegCM3 é mais próxima da observada do que a prevista pelo CPTEC/COLA. Além disto, o RegCM3 também é melhor previsor da chuva sazonal do que da média das observações nas três regiões. Para temperatura, as previsões do RegCM3 são superiores às do CPTEC/COLA nas áreas NDE e SUL, enquanto o CPTEC/COLA é superior no SDE. Finalmente, as previsões de chuva e temperatura do RegCM3 são mais próximas das observações do que a climatologia observada. Estes resultados indicam o potencial de utilização do RegCM3 para previsão sazonal, que futuramente deverá ser explorado através de previsão por conjunto.This study presents an assessment of seasonal forecasts from the regional climate model RegCM3 nested to the CPTEC/COLA global model. The used RegCM3 version is 60 km horizontal resolution over an area that includes large part of South America. RegCM3 and CPTEC/COLA forecasts were evaluated using the rainfall and air temperature analyses from Climate

Rosebud syncoal partnership SynCoal{sup {reg_sign}} demonstration technology development update

Energy Technology Data Exchange (ETDEWEB)

Sheldon, R.W. [Rosebud SynCoal Company, Billings, MT (United States); Heintz, S.J. [Department of Energy, Pittsburgh, PA (United States)

1995-12-01

Rosebud SynCoal{reg_sign} Partnership`s Advanced Coal Conversion Process (ACCP) is an advanced thermal coal upgrading process coupled with physical cleaning techniques to upgrade high moisture, low-rank coals to produce a high-quality, low-sulfur fuel. The coal is processed through two vibrating fluidized bed reactors where oxygen functional groups are destroyed removing chemically bound water, carboxyl and carbonyl groups, and volatile sulfur compounds. After thermal upgrading, the SynCoal{reg_sign} is cleaned using a deep-bed stratifier process to effectively separate the pyrite rich ash. The SynCoal{reg_sign} process enhances low-rank western coals with moisture contents ranging from 2555%, sulfur contents between 0.5 and 1.5 %, and heating values between 5,500 and 9,000 Btu/lb. The upgraded stable coal product has moisture contents as low as 1 %, sulfur contents as low as 0.3%, and heating values up to 12,000 Btu/lb.

Using fMRI to investigate a component process of reflection: prefrontal correlates of refreshing a just-activated representation.

Science.gov (United States)

Johnson, Marcia K; Raye, Carol L; Mitchell, Karen J; Greene, Erich J; Cunningham, William A; Sanislow, Charles A

2005-09-01

Using fMRI, we investigated the functional organization of prefrontal cortex (PFC) as participants briefly thought of a single just-experienced item (i.e., refreshed an active representation). The results of six studies, and a meta-analysis including previous studies, identified regions in left dorsolateral, anterior, and ventrolateral PFC associated in varying degrees with refreshing different types of information (visual and auditory words, drawings, patterns, people, places, or locations). In addition, activity increased in anterior cingulate with selection demands and in orbitofrontal cortex when a nonselected item was emotionally salient, consistent with a role for these areas in cognitive control (e.g., overcoming "mental rubbernecking"). We also found evidence that presenting emotional information disrupted an anterior component of the refresh circuit. We suggest that refreshing accounts for some neural activity observed in more complex tasks, such as working memory, long-term memory, and problem solving, and that its disruption (e.g., from aging or emotion) could have a broad impact.

Buscando sentido para a pesquisa e o ensino de regência verbal : uma abordagem funcional-cognitiva

OpenAIRE

Rodrigues, Tiago de Aguiar

2011-01-01

O conteúdo "regência verbal" tem sido trabalhado sistematicamente em sala de aula como uma simples repetição de regras. Para convencer os alunos a estudar regência, o professor os ensina a decorar uma lista infinda de verbos, com o argumento de que isso é necessário para obter sucesso nos concursos e vestibulares. Regência torna-se, então, sinônimo de decoreba, uma vez que, afora concursos e vestibulares, parece não ter outra finalidade. Assim, consolida-se um abismo entre a teoria escolar e ...

Two virtual astro refresher courses on the world-wide-web

International Nuclear Information System (INIS)

Goldwein, Joel W.

1997-01-01

Purpose/Objective: The Internet offers a novel venue for providing educational material to radiation oncologists. This exhibit demonstrates its utility for providing the complete content of two past ASTRO refresher courses. Materials and Methods: The audio recording, handout and slides from the 1995 ASTRO refresher course entitled 'Radiation Therapy for Pediatric Brain Tumors; Standards of Care, Current Clinical Trials and New Directions' and the 1996 ASTRO refresher course entitled 'Internet-based communications in Radiation Oncology' were digitized and placed on an Internet World-Wide-Web site. The Web address was posted on the refresher course handout and in the meeting book ('http://goldwein 1.xrt.upenn.edu/brain95.html' and 'http://goldwein 1.xrt.upenn.edu/astro96/'). The computer distributing this material is an Intel-based 486 DEC50 personal computer with a 50 Mhz processor running Windows NT 3.51 workstation. Software utilized to distribute the material is in the public domain and includes EWMAC's 'httpd', and Progressive Network's 'RealAudio Server' and 'Encoder'. The University's dedicated Internet connection is used to 'serve' this material. Results: The two approximately 100 minute lectures have been encoded into several 'RealAudio' files totaling 10 Megabytes in size. These files are accessible with moderate to excellent quality and speed utilizing as little as a 14.4k modem connection to the Internet. Use of 'streaming' technology provides a means for playing the audio files over the Internet after downloading only a small portion of the files. The time required to digitize the material has been approximately 40 hours, with most time related to digitizing slides from a Powerpoint presentation. Not all slides have been digitized as of this time. To date, approximately 400 accesses to this resource have been logged on the system. Seven electronic comment forms for the second course have all rated it as 'superior'. Pitfalls include the difficulty

RegRNA: an integrated web server for identifying regulatory RNA motifs and elements

OpenAIRE

Huang, Hsi-Yuan; Chien, Chia-Hung; Jen, Kuan-Hua; Huang, Hsien-Da

2006-01-01

Numerous regulatory structural motifs have been identified as playing essential roles in transcriptional and post-transcriptional regulation of gene expression. RegRNA is an integrated web server for identifying the homologs of regulatory RNA motifs and elements against an input mRNA sequence. Both sequence homologs and structural homologs of regulatory RNA motifs can be recognized. The regulatory RNA motifs supported in RegRNA are categorized into several classes: (i) motifs in mRNA 5′-untra...

A system for tracking braille readers using a Wii Remote and a refreshable braille display.

Science.gov (United States)

Aranyanak, Inthraporn; Reilly, Ronan G

2013-03-01

This article describes a cheap and easy-to-use finger-tracking system for studying braille reading. It provides improved spatial and temporal resolution over the current available solutions and can be used with either a refreshable braille display or braille-embossed paper. In conjunction with a refreshable braille display, the tracking system has the unique capacity to implement display-change paradigms derived from sighted reading research. This will allow researchers to probe skilled braille reading in significantly more depth than has heretofore been possible.

Feasibility of integrating other federal information systems into the Global Network of Environment and Technology, GNET{reg_sign}

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-05-01

The Global Environment and Technology Enterprise (GETE) of the Global Environment and Technology Foundation (GETF) has been tasked by the US Department of Energy`s (DOE), Federal Energy Technology Center (FETC) to assist in reducing DOE`s cost for the Global Network of Environment and Technology (GNET{reg_sign}). As part of this task, GETE is seeking federal partners to invest in GNET{reg_sign}. The authors are also seeking FETC`s commitment to serve as GNET`s federal agency champion promoting the system to potential agency partners. This report assesses the benefits of partnering with GNET{reg_sign} and provides recommendations for identifying and integrating other federally funded (non-DOE) environmental information management systems into GNET{reg_sign}.

CoryneRegNet 4.0 – A reference database for corynebacterial gene regulatory networks

Directory of Open Access Journals (Sweden)

Baumbach Jan

2007-11-01

Full Text Available Abstract Background Detailed information on DNA-binding transcription factors (the key players in the regulation of gene expression and on transcriptional regulatory interactions of microorganisms deduced from literature-derived knowledge, computer predictions and global DNA microarray hybridization experiments, has opened the way for the genome-wide analysis of transcriptional regulatory networks. The large-scale reconstruction of these networks allows the in silico analysis of cell behavior in response to changing environmental conditions. We previously published CoryneRegNet, an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks. Initially, it was designed to provide methods for the analysis and visualization of the gene regulatory network of Corynebacterium glutamicum. Results Now we introduce CoryneRegNet release 4.0, which integrates data on the gene regulatory networks of 4 corynebacteria, 2 mycobacteria and the model organism Escherichia coli K12. As the previous versions, CoryneRegNet provides a web-based user interface to access the database content, to allow various queries, and to support the reconstruction, analysis and visualization of regulatory networks at different hierarchical levels. In this article, we present the further improved database content of CoryneRegNet along with novel analysis features. The network visualization feature GraphVis now allows the inter-species comparisons of reconstructed gene regulatory networks and the projection of gene expression levels onto that networks. Therefore, we added stimulon data directly into the database, but also provide Web Service access to the DNA microarray analysis platform EMMA. Additionally, CoryneRegNet now provides a SOAP based Web Service server, which can easily be consumed by other bioinformatics software systems. Stimulons (imported from the database, or uploaded by the user can be analyzed in the context of known

RegA, an AraC-Like Protein, Is a Global Transcriptional Regulator That Controls Virulence Gene Expression in Citrobacter rodentium▿

Science.gov (United States)

Hart, Emily; Yang, Ji; Tauschek, Marija; Kelly, Michelle; Wakefield, Matthew J.; Frankel, Gad; Hartland, Elizabeth L.; Robins-Browne, Roy M.

2008-01-01

Citrobacter rodentium is an attaching and effacing pathogen which causes transmissible colonic hyperplasia in mice. Infection with C. rodentium serves as a model for infection of humans with enteropathogenic and enterohemorrhagic Escherichia coli. To identify novel colonization factors of C. rodentium, we screened a signature-tagged mutant library of C. rodentium in mice. One noncolonizing mutant had a single transposon insertion in an open reading frame (ORF) which we designated regA because of its homology to genes encoding members of the AraC family of transcriptional regulators. Deletion of regA in C. rodentium resulted in markedly reduced colonization of the mouse intestine. Examination of lacZ transcriptional fusions using promoter regions of known and putative virulence-associated genes of C. rodentium revealed that RegA strongly stimulated transcription of two newly identified genes located close to regA, which we designated adcA and kfcC. The cloned adcA gene conferred autoaggregation and adherence to mammalian cells to E. coli strain DH5α, and a kfc mutation led to a reduction in the duration of intestinal colonization, but the kfc mutant was far less attenuated than the regA mutant. These results indicated that other genes of C. rodentium whose expression required activation by RegA were required for colonization. Microarray analysis revealed a number of RegA-regulated ORFs encoding proteins homologous to known colonization factors. Transcription of these putative virulence determinants was activated by RegA only in the presence of sodium bicarbonate. Taken together, these results show that RegA is a global regulator of virulence in C. rodentium which activates factors that are required for intestinal colonization. PMID:18765720

RegA, an AraC-like protein, is a global transcriptional regulator that controls virulence gene expression in Citrobacter rodentium.

Science.gov (United States)

Hart, Emily; Yang, Ji; Tauschek, Marija; Kelly, Michelle; Wakefield, Matthew J; Frankel, Gad; Hartland, Elizabeth L; Robins-Browne, Roy M

2008-11-01

Citrobacter rodentium is an attaching and effacing pathogen which causes transmissible colonic hyperplasia in mice. Infection with C. rodentium serves as a model for infection of humans with enteropathogenic and enterohemorrhagic Escherichia coli. To identify novel colonization factors of C. rodentium, we screened a signature-tagged mutant library of C. rodentium in mice. One noncolonizing mutant had a single transposon insertion in an open reading frame (ORF) which we designated regA because of its homology to genes encoding members of the AraC family of transcriptional regulators. Deletion of regA in C. rodentium resulted in markedly reduced colonization of the mouse intestine. Examination of lacZ transcriptional fusions using promoter regions of known and putative virulence-associated genes of C. rodentium revealed that RegA strongly stimulated transcription of two newly identified genes located close to regA, which we designated adcA and kfcC. The cloned adcA gene conferred autoaggregation and adherence to mammalian cells to E. coli strain DH5alpha, and a kfc mutation led to a reduction in the duration of intestinal colonization, but the kfc mutant was far less attenuated than the regA mutant. These results indicated that other genes of C. rodentium whose expression required activation by RegA were required for colonization. Microarray analysis revealed a number of RegA-regulated ORFs encoding proteins homologous to known colonization factors. Transcription of these putative virulence determinants was activated by RegA only in the presence of sodium bicarbonate. Taken together, these results show that RegA is a global regulator of virulence in C. rodentium which activates factors that are required for intestinal colonization.

STARPOWER: An IMAX reg-sign Film on Fusion

International Nuclear Information System (INIS)

Kirsch, J.W.

1995-01-01

The Reuben H. Fleet Space Theater and Science Center and Four Square Productions, Inc. are producing STARPOWER, a new IMAX/OMNIMAX reg-sign film about thermonuclear fusion. The film's storyline will link our understanding of fusion as the power source of the stars with our current quest to develop a practical machine that uses fusion to produce electric power. The goal is to reach the world-wide audience of 40,000,000 people who visit IMAX/OMNIMAX reg-sign theaters each year, about half of which are in the United States and Canada. This document is the final report on a project to research and develop the concept. It was supported by grants from the Department of Energy (Museum Science Education Program), the International Space Theater Consortium (ISTC's Film Development Fund), and contributions by the Fleet Center and Four Square Productions. The report describes the development of the film's educational objectives, findings on the current state of fusion research, film treatments and marketing research for the project, preparation of the project prospectus, and planned next steps

Pilot test of Pickliq{reg_sign} process to determine energy and environmental benefits & economic feasibility

Energy Technology Data Exchange (ETDEWEB)

Olsen, D.R.

1997-07-13

Green Technology Group (GTG) was awarded Grant No. DE-FG01-96EE 15657 in the amount of $99,904 for a project to advance GTG`s Pickliq{reg_sign} Process in the Copper and Steel Industries. The use of the Pickliq{reg_sign} Process can significantly reduce the production of waste acids containing metal salts. The Pickliq{reg_sign} Process can save energy and eliminate hazardous waste in a typical copper rod or wire mill or a typical steel wire mill. The objective of this pilot project was to determine the magnitude of the economic, energy and environmental benefits of the Pickliq{reg_sign} Process in two applications within the metal processing industry. The effectiveness of the process has already been demonstrated at facilities cleaning iron and steel with sulfuric acid. 9207 companies are reported to use sulfuric and hydrochloric acid in the USA. The USEPA TRI statistics of acid not recycled in the US is 2.4 x 10{sup 9} lbs (net) for Hydrochloric Acid and 2.0 x 10{sup 9} lbs (net) for Sulfuric Acid. The energy cost of not reclaiming acid is 10.7 x 10{sup 6} BTU/ton for Hydrochloric Acid and 21.6 x 10{sup 6} BTU/Ton for Sulfuric Acid. This means that there is a very large market for the application of the Pickliq{reg_sign} Process and the widespread use of the process will bring significant world wide savings of energy to the environment.

NANoREG framework for the safety assessment of nanomaterials

OpenAIRE

Gottardo, Stefania; Alessandrelli, Maria; Amenta, Valeria; Atluri, Rambabu; Barberio, Grazia; Bekker, Cindy; Bergonzo, Philippe; Bleeker, Eric; Booth, Andy; Borges, Teresa; Buttol, Patrizia; Carlander, David; Castelli, Stefano; Chevillard, Sylvie

2017-01-01

The NANoREG framework addresses the need to ease the nanomaterials safety assessment in the REACH Regulation context. It offers forward-looking strategies: Safe-by-Design, a Nanospecific Prioritisation and Risk Assessment, and Life Cycle Assessment. It is intended for scientific experts, regulatory authorities and industry.

Description and evaluation of the Earth System Regional Climate Model (RegCM-ES)

Science.gov (United States)

Farneti, Riccardo; Sitz, Lina; Di Sante, Fabio; Fuentes-Franco, Ramon; Coppola, Erika; Mariotti, Laura; Reale, Marco; Sannino, Gianmaria; Barreiro, Marcelo; Nogherotto, Rita; Giuliani, Graziano; Graffino, Giorgio; Solidoro, Cosimo; Giorgi, Filippo

2017-04-01

The increasing availability of satellite remote sensing data, of high temporal frequency and spatial resolution, has provided a new and enhanced view of the global ocean and atmosphere, revealing strong air-sea coupling processes throughout the ocean basins. In order to obtain an accurate representation and better understanding of the climate system, its variability and change, the inclusion of all mechanisms of interaction among the different sub-components, at high temporal and spatial resolution, becomes ever more desirable. Recently, global coupled models have been able to progressively refine their horizontal resolution to attempt to resolve smaller-scale processes. However, regional coupled ocean-atmosphere models can achieve even finer resolutions and provide additional information on the mechanisms of air-sea interactions and feedbacks. Here we describe a new, state-of-the-art, Earth System Regional Climate Model (RegCM-ES). RegCM-ES presently includes the coupling between atmosphere, ocean, land surface and sea-ice components, as well as an hydrological and ocean biogeochemistry model. The regional coupled model has been implemented and tested over some of the COordinated Regional climate Downscaling Experiment (CORDEX) domains. RegCM-ES has shown improvements in the representation of precipitation and SST fields over the tested domains, as well as realistic representations of coupled air-sea processes and interactions. The RegCM-ES model, which can be easily implemented over any regional domain of interest, is open source making it suitable for usage by the large scientific community.

Reflective Lesson Planning in Refresher Training Programs for Experienced Physics Teachers.

Science.gov (United States)

Chung, C. M.; And Others

1995-01-01

Reports on a refresher training program that introduces experienced physics teachers to a reflective lesson-planning model and a more constructivist approach to physics teaching. Three instructional strategies developed by participants in the program and the corresponding suggestions made by their peers are presented and analyzed. (29 references)…

CoryneRegNet: an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks.

Science.gov (United States)

Baumbach, Jan; Brinkrolf, Karina; Czaja, Lisa F; Rahmann, Sven; Tauch, Andreas

2006-02-14

The application of DNA microarray technology in post-genomic analysis of bacterial genome sequences has allowed the generation of huge amounts of data related to regulatory networks. This data along with literature-derived knowledge on regulation of gene expression has opened the way for genome-wide reconstruction of transcriptional regulatory networks. These large-scale reconstructions can be converted into in silico models of bacterial cells that allow a systematic analysis of network behavior in response to changing environmental conditions. CoryneRegNet was designed to facilitate the genome-wide reconstruction of transcriptional regulatory networks of corynebacteria relevant in biotechnology and human medicine. During the import and integration process of data derived from experimental studies or literature knowledge CoryneRegNet generates links to genome annotations, to identified transcription factors and to the corresponding cis-regulatory elements. CoryneRegNet is based on a multi-layered, hierarchical and modular concept of transcriptional regulation and was implemented by using the relational database management system MySQL and an ontology-based data structure. Reconstructed regulatory networks can be visualized by using the yFiles JAVA graph library. As an application example of CoryneRegNet, we have reconstructed the global transcriptional regulation of a cellular module involved in SOS and stress response of corynebacteria. CoryneRegNet is an ontology-based data warehouse that allows a pertinent data management of regulatory interactions along with the genome-scale reconstruction of transcriptional regulatory networks. These models can further be combined with metabolic networks to build integrated models of cellular function including both metabolism and its transcriptional regulation.

Bicarbonate-mediated transcriptional activation of divergent operons by the virulence regulatory protein, RegA, from Citrobacter rodentium.

Science.gov (United States)

Yang, Ji; Hart, Emily; Tauschek, Marija; Price, G Dean; Hartland, Elizabeth L; Strugnell, Richard A; Robins-Browne, Roy M

2008-04-01

Regulation of virulence gene expression plays a central role in the pathogenesis of enteric bacteria as they encounter diverse environmental conditions in the gastrointestinal tract of their hosts. In this study, we investigated environmental regulation of two putative virulence determinants adcA and kfc by RegA, an AraC/XylS-like regulator, from Citrobacter rodentium, and identified bicarbonate as the environmental signal which induced transcription of adcA and kfc through RegA. Primer extension experiments showed that adcA and kfc were divergently transcribed from sigma(70) promoters. In vivo and in vitro experiments demonstrated that bicarbonate facilitated and stabilized the binding of RegA to an operator located between the two promoters. The interaction of RegA with its DNA target resulted in the formation of a nucleosome-like structure, which evidently displaced the histone-like proteins, H-NS and StpA, from the adcA and kfc promoter regions, leading to transcriptional derepression. In addition, our results indicated that RegA also behaved as a Class I activator by directly stimulating transcription initiation by RNA polymerase. This is the first report to describe the molecular mechanism by which an environmental chemical stimulates transcription of virulence-associated genes of an enteric pathogen through an AraC/XlyS-like activator.

A new bistable electroactive polymer for prolonged cycle lifetime of refreshable Braille displays

Science.gov (United States)

Ren, Zhi; Niu, Xiaofan; Chen, Dustin; Hu, Wei; Pei, Qibing

2014-03-01

ABSTRACT: Bistable electroactive polymers (BSEP) amalgamating electrically induced large-strain actuation and shape memory effect present a unique opportunity for refreshable Braille displays. A new BSEP material with long-chain crosslinkers to achieve prolonged cycle lifetime of refreshable Braille displays is reported here. The modulus of the BSEP material decreases by more than three orders of magnitude from a rigid, plastic state to a rubbery state when heated above the polymer's glass transition temperature. In its rubbery state, the polymer film can be electrically actuated to buckle convexly when a high voltage is applied across a circular active area. Modifying the concentration of long-chain crosslinkers in the polymer allows not only for fine-tuning of the polymer's glass transition temperature and elasticity in the rubbery state, but also enhancement of the actuation stability. For a raised height of 0.4 mm by a Braille dot with a 1.3 mm diameter, actuation can be repeated over 2000 cycles at 70°C in the rubbery state. The actuated dome shape can be fixed by cooling the polymer below the glass transition temperature. This refreshable rigid-to-rigid actuation simultaneously provides large-strain actuation and large force support. Devices capable of displaying Braille characters over a page-size area consisting of 324 Braille cells have been fabricated.

The efficacy of Xialine[reg] in patients with xerostomia resulting from radiotherapy for head and neck cancer: a pilot-study

International Nuclear Information System (INIS)

Jellema, Anke Petra; Langendijk, Hans; Bergenhenegouwen, Lester; Reijden, Willy van der; Leemans, Rene; Smeele, Ludy; Slotman, Berend J.

2001-01-01

Changes in subjective sensations due to xerostomia before and after administration of Xialine [reg] , a xanthan gum-based saliva substitute, were evaluated in 30 patients with radiation-induced xerostomia using the QLQ-H and N35. Xerostomia in general decreased with both Xialine [reg] and placebo to almost the same degree. A trend was seen for Xialine [reg] to improve problems with speech and senses

CoryneRegNet: An ontology-based data warehouse of corynebacterial transcription factors and regulatory networks

Directory of Open Access Journals (Sweden)

Czaja Lisa F

2006-02-01

Full Text Available Abstract Background The application of DNA microarray technology in post-genomic analysis of bacterial genome sequences has allowed the generation of huge amounts of data related to regulatory networks. This data along with literature-derived knowledge on regulation of gene expression has opened the way for genome-wide reconstruction of transcriptional regulatory networks. These large-scale reconstructions can be converted into in silico models of bacterial cells that allow a systematic analysis of network behavior in response to changing environmental conditions. Description CoryneRegNet was designed to facilitate the genome-wide reconstruction of transcriptional regulatory networks of corynebacteria relevant in biotechnology and human medicine. During the import and integration process of data derived from experimental studies or literature knowledge CoryneRegNet generates links to genome annotations, to identified transcription factors and to the corresponding cis-regulatory elements. CoryneRegNet is based on a multi-layered, hierarchical and modular concept of transcriptional regulation and was implemented by using the relational database management system MySQL and an ontology-based data structure. Reconstructed regulatory networks can be visualized by using the yFiles JAVA graph library. As an application example of CoryneRegNet, we have reconstructed the global transcriptional regulation of a cellular module involved in SOS and stress response of corynebacteria. Conclusion CoryneRegNet is an ontology-based data warehouse that allows a pertinent data management of regulatory interactions along with the genome-scale reconstruction of transcriptional regulatory networks. These models can further be combined with metabolic networks to build integrated models of cellular function including both metabolism and its transcriptional regulation.

Spent nuclear fuel application of CORE reg-sign systems engineering software

International Nuclear Information System (INIS)

Grimm, R.J.

1996-01-01

The DOE has adopted a systems engineering approach for the successful completion of the Spent Nuclear Fuel (SNF) Program mission. The DOE has utilized systems engineering principles to develop the SNF program guidance documents and has held several systems engineering workshops to develop the functional hierarchies of both the programmatic and technical side of the SNF program. The sheer size and complexity of the SNF program has led to problems that the Westinghouse Savannah River Company (WSRC) is working to manage through the use of systems engineering software. WSRC began using CORE reg-sign, an off the shelf PC based software package, to assist DOE in management of the SNF program. This paper details the successful use of the CORE reg-sign systems engineering software to date and the proposed future activities

The Reg1-interacting proteins, Bmh1, Bmh2, Ssb1, and Ssb2, have roles in maintaining glucose repression in Saccharomyces cerevisiae.

Science.gov (United States)

Dombek, Kenneth M; Kacherovsky, Nataly; Young, Elton T

2004-09-10

In Saccharomyces cerevisiae, a type 1 protein phosphatase complex composed of the Glc7 catalytic subunit and the Reg1 regulatory subunit represses expression of many glucose-regulated genes. Here we show that the Reg1-interacting proteins Bmh1, Bmh2, Ssb1, and Ssb2 have roles in glucose repression. Deleting both BMH genes causes partially constitutive ADH2 expression without significantly increasing the level of Adr1 protein, the major activator of ADH2 expression. Adr1 and Bcy1, the regulatory subunit of cAMP-dependent protein kinase, are both required for this effect indicating that constitutive expression in Deltabmh1Deltabmh2 cells uses the same activation pathway that operates in Deltareg1 cells. Deletion of both BMH genes and REG1 causes a synergistic relief from repression, suggesting that Bmh proteins also act independently of Reg1 during glucose repression. A two-hybrid interaction with the Bmh proteins was mapped to amino acids 187-232, a region of Reg1 that is conserved in different classes of fungi. Deleting this region partially releases SUC2 from glucose repression. This indicates a role for the Reg1-Bmh interaction in glucose repression and also suggests a broad role for Bmh proteins in this process. An in vivo Reg1-Bmh interaction was confirmed by copurification of Bmh proteins with HA(3)-TAP-tagged Reg1. The nonconventional heat shock proteins Ssb1 and Ssb2 are also copurified with HA(3)-TAP-tagged Reg1. Deletion of both SSB genes modestly decreases repression of ADH2 expression in the presence of glucose, suggesting that Ssb proteins, perhaps through their interaction with Reg1, play a minor role in glucose repression.

The Regional Earth System Model (RegESM) using RegCM4 coupled with the MITgcm ocean model: First assessments over the MED-CORDEX domain

Science.gov (United States)

Mariotti, Laura; Utku Turunçoǧlu, Ufuk; Farneti, Riccardo; Sannino, Gianmaria; Vittoria Struglia, Maria; Carillo, Adriana; Giorgi, Filippo

2016-04-01

In the framework of global climate studies, there is an increasingly growing concern about the vulnerability of the Mediterranean region, where high population density and intense exploitation activities pose severe questions on the sustainability of terrestrial water management, both for the present and the future. Ocean modeling studies suggest that the Mediterranean thermohaline circulation could be weakened in conditions of global greenhouse warming, an event which would undoubtedly affect regional climate, possibly triggering global feedback processes. Experiments with the atmosphere-ocean coupled system confirmed that a good comprehension of Mediterranean processes requires the explicit inclusion of the feedbacks between the atmospheric and the oceanic components, thus achieving a complete, fully coupled description of the Mediterranean hydrological cycle, at the same time gaining new insights in our current ability to reproduce the atmospheric hydrological processes and to close the hydrological balance. These issues are addressed by the upgraded PROTHEUS system which was jointly developed by ENEA and ICTP. Here we present a first evaluation of the performances of the new PROTHEUS system (called PROTHEUS 2.0) composed by the regional climate model RegCM4 (Giorgi et al. 2012) coupled with both the ocean model MITgcm (Marshall J. et al. 1997a,b) and the HD river model (Max-Planck's HD model; Hagemann and Dümenil, 1998) using RegESM (Regional Earth System Model) as a driver. The three-component (atmosphere, ocean and river routing) fully coupled model exchanges sea surface temperature (SST) from the ocean to the atmospheric model, surface wind stress, energy and freshwater fluxes from the atmosphere to the ocean model, surface and sub-surface runoff from the atmospheric component to the river routing model (Max-Planck's HD model; Hagemann and Dümenil, 1998). In order to have water conservation within the system, the river routing component sends the

RegPrecise 3.0--a resource for genome-scale exploration of transcriptional regulation in bacteria.

Science.gov (United States)

Novichkov, Pavel S; Kazakov, Alexey E; Ravcheev, Dmitry A; Leyn, Semen A; Kovaleva, Galina Y; Sutormin, Roman A; Kazanov, Marat D; Riehl, William; Arkin, Adam P; Dubchak, Inna; Rodionov, Dmitry A

2013-11-01

Genome-scale prediction of gene regulation and reconstruction of transcriptional regulatory networks in prokaryotes is one of the critical tasks of modern genomics. Bacteria from different taxonomic groups, whose lifestyles and natural environments are substantially different, possess highly diverged transcriptional regulatory networks. The comparative genomics approaches are useful for in silico reconstruction of bacterial regulons and networks operated by both transcription factors (TFs) and RNA regulatory elements (riboswitches). RegPrecise (http://regprecise.lbl.gov) is a web resource for collection, visualization and analysis of transcriptional regulons reconstructed by comparative genomics. We significantly expanded a reference collection of manually curated regulons we introduced earlier. RegPrecise 3.0 provides access to inferred regulatory interactions organized by phylogenetic, structural and functional properties. Taxonomy-specific collections include 781 TF regulogs inferred in more than 160 genomes representing 14 taxonomic groups of Bacteria. TF-specific collections include regulogs for a selected subset of 40 TFs reconstructed across more than 30 taxonomic lineages. Novel collections of regulons operated by RNA regulatory elements (riboswitches) include near 400 regulogs inferred in 24 bacterial lineages. RegPrecise 3.0 provides four classifications of the reference regulons implemented as controlled vocabularies: 55 TF protein families; 43 RNA motif families; ~150 biological processes or metabolic pathways; and ~200 effectors or environmental signals. Genome-wide visualization of regulatory networks and metabolic pathways covered by the reference regulons are available for all studied genomes. A separate section of RegPrecise 3.0 contains draft regulatory networks in 640 genomes obtained by an conservative propagation of the reference regulons to closely related genomes. RegPrecise 3.0 gives access to the transcriptional regulons reconstructed in

Comparison of plastic and orfit[reg] masks for patient head fixation during radiotherapy: precision and costs

International Nuclear Information System (INIS)

Weltens, Caroline; Kesteloot, Katrien; Vandevelde, Guy; Van den Bogaert, Walter

1995-01-01

Purpose: Two widely used immobilization systems for head fixation during radiotherapy treatment for ear-nose-throat (ENT) tumors are evaluated. Methods and Materials: Masks made of poly vinyl-chloride (plastuc) are compared to thermoplastic masks (Orfit[reg]) with respect to the accuracy of the treatment setup and the costs. For both types of material, a cut-out (windows corresponding to treatment fields) and a full mask (not cut out) are considered. Forty-three patients treated for ENT tumors were randomized into four groups, to be fixed by one of the following modalities: cut-out plastic mask (12 patients), full plastic mask (11 patients), cut-out Orfit[reg] mask (10 patients), and full Orfit[reg] mask (10 patients). Results: Reproducibility of the treatment setup was assessed by calculating the deviations from the mean value for each individual patient and was demonstrated to be identical for all subgroups: no differences were demonstrated between the plastic (s = 2.1 mm) and the Orfit[reg] (s = 2.1 mm) group nor between the cut-out (s = 2.0 mm) and not cut-out (s = 2.1 mm) group. The transfer chain from simulator to treatment unit was checked by comparing portal images to their respective simulation image, and no differences between the four subgroups (s = ±3.5 mm) could be detected. A methodology was described to compare the costs of both types of masks, and illustrated with the data for a department. It was found that Orfit[reg] masks are a cheaper alternative than plastic masks; they require much less investment expenses and the workload and material cost of the first mask for each patient is also lower. Cut-out masks are more expensive than full masks, because of the higher workload and the additional material required for second and third masks that are required in case of field modifications. Conclusions: No substantial difference in patient setup accuracy between both types of masks was detected, and cutting out the masks had no impact on the fixing

Spent nuclear fuel application of CORE reg-sign systems engineering software

International Nuclear Information System (INIS)

Grimm, R.J.

1996-01-01

The Department of Energy (DOE) has adopted a systems engineering approach for the successful completion of the Spent Nuclear Fuel (SNF) Program mission. The DOE has utilized systems engineering principles to develop the SNF Program guidance documents and has held several systems engineering workshops to develop the functional hierarchies of both the programmatic and technical side of the SNF Program. The sheer size and complexity of the SNF Program, however, has led to problems that the Westinghouse Savannah River Company (WSRC) is working to manage through the use of systems engineering software. WSRC began using CORE reg-sign, an off-the-shelf PC based software package, to assist the DOE in management of the SNF program. This paper details the successful use of the CORE reg-sign systems engineering software to date and the proposed future activities

Influence of refreshment/activation cycles and temperature rise on the reaction rate of sodium hypochlorite with bovine dentine during ultrasonic activated irrigation.

Science.gov (United States)

Macedo, R G; Verhaagen, B; Wesselink, P R; Versluis, M; van der Sluis, L W M

2014-02-01

To evaluate the effect of multiple refreshment/activation cycles and temperature on the reaction rate of sodium hypochlorite (NaOCl) with bovine dentine during ultrasonic activated irrigation (UAI) under laboratory conditions. The root canal walls of 24 standardized root canals in bovine incisors were exposed to a standardized volume of NaOCl at different temperatures (24 °C and 38 °C) and exposure times (20, 60 and 180 s). The irrigant was refreshed and ultrasonically activated four times for 20 s followed by a 40 s rest interval, with no refreshment and no activation as the controls. The reaction rate was determined by measuring the amount of active chlorine in the NaOCl solution before and after being exposed to dentine during the specific experimental conditions. Calorimetry was used to measure the electrical-to-sonochemical conversion efficiency during ultrasonic activation. Refreshment, activation and exposure time all increased the reaction rate of NaOCl (P reaction rate of NaOCl (P > 0.125). The reaction rate of NaOCl with dentine is enhanced by refreshment, ultrasonic activation and exposure time. Temperature rise of irrigant during ultrasonic activation was not sufficient to alter the reaction rate. © 2013 International Endodontic Journal. Published by John Wiley & Sons Ltd.

Method for improving the use of PASCO brand spectrophotometer using DataStudio program applied to radiometric surveys for LAFTLA

International Nuclear Information System (INIS)

Bolanos Rodriguez, Gary

2008-01-01

Escuela de Ingenieria Electrica at the Universidad de Costa Rica has developed a procedure for the improved use of a PASCO brand Spectrophotometer of the Laboratorio de Fotonica y Tecnologia Laser Aplicada. The program has used DataStudio for the application in radiometric surveys in LAFTLA. Important conclusions have been obtained by the assembly of optical experiments, software and data collection and analysis, such as the behavior of a emitting source radiation known as black body and its relation to the temperature, wavelength and intensity of light. The user guide has been detailed exposing calibrations of the sensors, the definition of constants needed for obtaining parameters and assembly and commissioning of the equipment. (author) [es

The regional climate model RegCM3 performances over several regions and climate regimes

Science.gov (United States)

Coppola, E.; Rauscher, S.; Gao, X.; Giorgi, F.; Im, E. S.; Mariotti, L.; Seth, A.; Sylla, M. B.

2009-04-01

Regional Climate models are more and more needed to provide high resolution regional climate information in climate impact studies. Water availability in a future scenario is the main request of policy makers for adaptation and mitigation purposes. However precipitation changes are unlikely to be as spatially coherent as temperature changes and they are closely related to the regional model itself. In addition model skill varies regionally. An example of several ICTP regional climate model (RegCM3) simulations is reported over China, Korea, Africa, Central and Southern America, Europe and Australia. Over China, Australia, and Korea the regional model improves the simulation compared to the driving GCM when compared with CRU observations. In China, for example, the higher resolution of the regional model inhibits the penetration of the monsoon precipitation front from the southern slope of the Himalaya onto the Tibetan Plateau. In Korea the nested domain simulation (20 km) shows an encouraging performance with regard to capturing extreme precipitation episodes and the finer spatial distribution reflects the detailed geography of the Korean Peninsula. Over South America, RegCM captures the annual cycle of precipitation over Northeast Brazil and the South American Monsoon region, although the monsoon onset occurs too early in the model. Precipitation over the Amazon is not well captured, with too little precipitation associated with weak easterlies and reduced moisture transport into the interior of the continent. RegCM simulates the annual cycle of precipitation over Central America and the Caribbean fairly well; in particular, the complex spatial distribution of the Mid-Summer Drought, a decrease in precipitation that occurs during the middle of the rainy season in July and August, is better captured by RegCM than by the GCM. In addition, RegCM simulates the strength and position of the Caribbean low level jet, a mesoscale feature related to precipitation anomalies

Rosebud SynCoal Partnership, SynCoal{reg_sign} demonstration technology update

Energy Technology Data Exchange (ETDEWEB)

Sheldon, R.W. [Rosebud SynCoal Partnership, Billings, MT (United States)

1997-12-31

An Advanced Coal Conversion Process (ACCP) technology being demonstrated in eastern Montana (USA) at the heart of one of the world`s largest coal deposits is providing evidence that the molecular structure of low-rank coals can be altered successfully to produce a unique product for a variety of utility and industrial applications. The product is called SynCoal{reg_sign} and the process has been developed by the Rosebud SynCoal Partnership (RSCP) through the US Department of Energy`s multi-million dollar Clean Coal Technology Program. The ACCP demonstration process uses low-pressure, superheated gases to process coal in vibrating fluidized beds. Two vibratory fluidized processing stages are used to heat and convert the coal. This is followed by a water spray quench and a vibratory fluidized stage to cool the coal. Pneumatic separators remove the solid impurities from the dried coal. There are three major steps to the SynCoal{reg_sign} process: (1) thermal treatment of the coal in an inert atmosphere, (2) inert gas cooling of the hot coal, and (3) removal of ash minerals. When operated continuously, the demonstration plant produces over 1,000 tons per day (up to 300,000 tons per year) of SynCoal{reg_sign} with a 2% moisture content, approximately 11,800b Btu/lb and less than 1.0 pound of SO{sub 2} per million Btu. This product is obtained from Rosebud Mine sub-bituminous coal which starts with 25% moisture, 8,600 Btu/lb and approximately 1.6 pounds of SO{sub 2} per million Btu.

Recent development in crystal growth of large-diameter Y-QMG (reg sign) bulk superconductors; Y kei ogata QMG (reg sign) baruku koonchodendotai no kaihatsu jokyo

Energy Technology Data Exchange (ETDEWEB)

Fujimoto, T.; Morita, M. [Nippon Steel Corporation, Tokyo (Japan); Masahashi, N. [Tohoku University, Miyagi (Japan). Institute for Materials Research

1999-11-25

The current status of large-diameter Y-Ba-Cu-O OMG(reg sign) bulk superconductors is described. 75 mm-diameter QMG(reg sign) samples with fairly concentric trapped-magnetic-flux-density distributions have been successfully grown. In addition, a record-high value of the magnetic levitation force, 171 kgf, measured at 77 K using a 90 mm-diameter Nd-Fe-B magnet has been obtained for a 100 mm-diameter sample. The crystal orientation of subgrains in the sample was determined using Electron Back-Scattering Diffraction as well as using a conventional optical apparatus including a He-Ne-laser. For the sample grown under normal process conditions, the maximum value of the [001]-axis misorientation angles at the subgrain-boundaries we obtained in the c-substructure region is 2.9 degree. However, in the a/b-substructure regions, the misorientation angles are larger, and the maximum value obtained is 6.6 degree, exceeding the critical angle at which a significant reduction of the critical current density occurs in Y123 thin films due to the weak-link problem. (author)

A refreshing beverage from mature coconut water blended with lemon juice

OpenAIRE

Chauhan, O. P.; Archana, B. S.; Singh, Asha; Raju, P. S.; Bawa, A. S.

2012-01-01

Coconut water obtained from the mature coconuts was blended with lemon juice to develop a refreshing beverage. The levels of total soluble solids (°Brix) in the coconut beverage and lemon juice (%), were optimized using response surface methodology and considering pH, CIE L* value and sensory attributes (colour, aroma, taste, consistency and overall acceptability) as responses. A number total of 14 experiments were carried out following Central Composite Rotatable Design (CCRD) keeping 6 expe...

CANDU reg-sign -- A Canadian energy system

International Nuclear Information System (INIS)

Sejnoha, R.

1994-01-01

Uranium is one of Canada's important natural resources. It is perhaps not surprising that a country with such an abundance of uranium developed its own inexpensive, safe, and environmentally friendly system of energy generation, based on uranium: CANDU reg-sign (CANada-Deuterium-Uranium, a registered trademark of AECL). The objective of this paper is to describe briefly the main features of the CANDU system and explain methods used to assure the compatibility with the requirements for a clean and safe environment. The paper describes the CANDU reactor, and discusses storage of spent fuel, reactor performance, normal operating conditions, safety under accident conditions, and quality assurance in design, manufacturing, and operation

Effectiveness of an educational video as an instrument to refresh and reinforce the learning of a nursing technique: a randomized controlled trial.

Science.gov (United States)

Salina, Loris; Ruffinengo, Carlo; Garrino, Lorenza; Massariello, Patrizia; Charrier, Lorena; Martin, Barbara; Favale, Maria Santina; Dimonte, Valerio

2012-05-01

The Undergraduate Nursing Course has been using videos for the past year or so. Videos are used for many different purposes such as during lessons, nurse refresher courses, reinforcement, and sharing and comparison of knowledge with the professional and scientific community. The purpose of this study was to estimate the efficacy of the video (moving an uncooperative patient from the supine to the lateral position) as an instrument to refresh and reinforce nursing techniques. A two-arm randomized controlled trial (RCT) design was chosen: both groups attended lessons in the classroom as well as in the laboratory; a month later while one group received written information as a refresher, the other group watched the video. Both groups were evaluated in a blinded fashion. A total of 223 students agreed to take part in the study. The difference observed between those who had seen the video and those who had read up on the technique turned out to be an average of 6.19 points in favour of the first (P video were better able to apply the technique, resulting in a better performance. The video, therefore, represents an important tool to refresh and reinforce previous learning.

Mineralized breccia clasts: a window into hidden porphyry-type mineralization underlying the epithermal polymetallic deposit of Cerro de Pasco (Peru)

Science.gov (United States)

Rottier, Bertrand; Kouzmanov, Kalin; Casanova, Vincent; Bouvier, Anne-Sophie; Baumgartner, Lukas P.; Wälle, Markus; Fontboté, Lluís

2018-01-01

Cerro de Pasco (Peru) is known for its large epithermal polymetallic (Zn-Pb-Ag-Cu-Bi) mineralization emplaced at shallow level, a few hundred meters below the paleo-surface, at the border of a large diatreme-dome complex. Porphyry-style veins crosscutting hornfels and magmatic rock clasts are found in the diatreme breccia and in quartz-monzonite porphyry dikes. Such mineralized veins in clasts allow investigation of high-temperature porphyry-style mineralization developed in the deep portions of magmatic-hydrothermal systems. Quartz in porphyry-style veins contains silicate melt inclusions as well as fluid and solid mineral inclusions. Two types of high-temperature (> 600 °C) quartz-molybdenite-(chalcopyrite)-(pyrite) veins are found in the clasts. Early, thin (1-2 mm), and sinuous HT1 veins are crosscut by slightly thicker (up to 2 cm) and more regular HT2 veins. The HT1 vein quartz hosts CO2- and sulfur-rich high-density vapor inclusions. Two subtypes of the HT1 veins have been defined, based on the nature of mineral inclusions hosted in quartz: (i) HT1bt veins with inclusions of K-feldspar, biotite, rutile, and minor titanite and (ii) HT1px veins with inclusions of actinolite, augite, titanite, apatite, and minor rutile. Using an emplacement depth of the veins of between 2 and 3 km (500 to 800 bar), derived from the diatreme breccia architecture and the supposed erosion preceding the diatreme formation, multiple mineral thermobarometers are applied. The data indicate that HT1 veins were formed at temperatures > 700 °C. HT2 veins host assemblages of polyphase brine inclusions, generally coexisting with low-density vapor-rich inclusions, trapped at temperatures around 600 °C. Rhyolitic silicate melt inclusions found in both HT1 and HT2 veins represent melt droplets transported by the ascending hydrothermal fluids. LA-ICP-MS analyses reveal a chemical evolution coherent with the crystallization of an evolved rhyolitic melt. Quartz from both HT1 and HT2 veins

Topical safety analysis report for the transportation of the NUHOMS reg-sign dry shielded canister

International Nuclear Information System (INIS)

1993-08-01

This Topical Safety Analysis Report (SAR) describes the design and the generic transportation licensing basis for utilizing the NUTECH HORIZONTAL MODULAR STORAGE (NUHOMS reg-sign) system dry shielded canister (DSC) containing twenty-four pressurized water reactor (PWR) spent fuel assemblies (SFA) in conjunction with a conceptually designed Transportation Cask. This SAR documents the design qualification of the NUHOMS reg-sign DSC as an integral part of a 10CFR71 Fissile Material Class III, Type B(M) Transportation Package. The package consists of the canister and a conceptual transportation cask (NUHOMS reg-sign Transportation Cask) with impact limiters. Engineering analysis is performed for the canister to confirm that the existing canister design complies with 10CFR71 transportation requirements. Evaluations and/or analyses is performed for criticality safety, shielding, structural, and thermal performance. Detailed engineering analysis for the transportation cask will be submitted in a future SAR requesting 10CFR71 certification of the complete waste package. Transportation operational considerations describe various operational aspects of the canister/transportation cask system. operational sequences are developed for canister transfer from storage to the transportation cask and interfaces with the cask auxiliary equipment for on- and off-site transport

Impact of the reg1 mutation glycocen accumulation and glucose consumption rates in Saccharomyces cerevisiae cells based on a macrokinetic model

Directory of Open Access Journals (Sweden)

Rocha-Leão M.H.M.

2003-01-01

Full Text Available In S. cerevisiae, catabolite repression controls glycogen accumulation and glucose consumption. Glycogen is responsible for stress resistance, and its accumulation in derepression conditions results in a yeast with good quality. In yeast cells, catabolite repression also named glucose effect takes place at the transcriptional levels, decreasing enzyme respiration and causing the cells to enter a fermentative metabolism, low cell mass yield and yeast with poor quality. Since glucose is always present in molasses the glucose effect occurs in industrial media. A quantitative characterization of cell growth, substrate consumption and glycogen formation was undertaken based on an unstructured macrokinetic model for a reg1/hex2 mutant, capable of the respiration while growing on glucose, and its isogenic repressible strain (REG1/HEX2. The results show that the estimated value to maximum specific glycogen accumulation rate (muG,MAX is eight times greater in the reg1/hex2 mutant than its isogenic strain, and the glucose affinity constant (K SS is fifth times greater in reg1/hex2 mutant than in its isogenic strain with less glucose uptake by the former channeling glucose into cell mass growth and glycogen accumulation simultaneously. This approach may be one more tool to improve the glucose removal in yeast production. Thus, disruption of the REG1/HEX2 gene may constitute an important strategy for producing commercial yeast.

On the ability of RegCM4 to simulate surface solar radiation patterns over Europe: An assessment using satellite-based observations

Science.gov (United States)

Alexandri, Georgia; Georgoulias, Aristeidis K.; Zanis, Prodromos; Tsikerdekis, Athanasios; Katragkou, Eleni; Kourtidis, Konstantinos; Meleti, Charikleia

2015-04-01

We assess here the ability of RegCM4 to simulate the surface solar radiation (SSR) patterns over the European domain. For the needs of this work, a decadal (1999-2009) simulation was implemented at a horizontal resolution of 50km using the first year as a spin-up. The model is driven by emissions from CMIP5 while ERA-interim data were used as lateral boundary conditions. The RegCM4 SSR fields were validated against satellite-based SSR observations from Meteosat First Generation (MFG) and Meteosat Second Generation (MSG) sensors (CM SAF SIS product). The RegCM4 simulations slightly overestimate SSR compared to CM SAF over Europe with the bias being +1.54% in case of MFG (2000-2005) and +3.34% in case of MSG (2006-2009). SSR from RegCM4 is much closer to SSR from CM SAF over land (bias of -1.59% for MFG and +0.66% for MSG) than over ocean (bias of +7.20% for MFG and 8.07% for MSG). In order to understand the reasons of this bias, we proceeded to a detailed assessment of various parameters that define the SSR levels (cloud fractional cover - CFC, cloud optical thickness - COT, cloud droplet effective radius - Re, aerosol optical thickness - AOD, asymmetry factor - ASY, single scattering albedo - SSA, water vapor - WV and surface albedo - ALB). We validated the simulated CFC, COT and Re from RegCM4 against satellite-based observations from MSG and we found that RegCM4 significantly underestimates CFC and Re, and overestimates COT over Europe. The aerosol-related parameters from RegCM4 were compared with values from the aerosol climatology taken into account within CM SAF SSR estimates. AOD is significantly underestimated in our simulations which leads to a positive SSR bias. The RegCM4 WV and ALB were compared with WV values from ERA-interim and ALB climatological observations from CERES which are also taken into account within CM SAF SSR estimates. Finally, with the use of a radiative transfer model (SBDART) we manage to quantify the relative contribution of each of

HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease.

Science.gov (United States)

Ward, Lucas D; Kellis, Manolis

2016-01-04

More than 90% of common variants associated with complex traits do not affect proteins directly, but instead the circuits that control gene expression. This has increased the urgency of understanding the regulatory genome as a key component for translating genetic results into mechanistic insights and ultimately therapeutics. To address this challenge, we developed HaploReg (http://compbio.mit.edu/HaploReg) to aid the functional dissection of genome-wide association study (GWAS) results, the prediction of putative causal variants in haplotype blocks, the prediction of likely cell types of action, and the prediction of candidate target genes by systematic mining of comparative, epigenomic and regulatory annotations. Since first launching the website in 2011, we have greatly expanded HaploReg, increasing the number of chromatin state maps to 127 reference epigenomes from ENCODE 2012 and Roadmap Epigenomics, incorporating regulator binding data, expanding regulatory motif disruption annotations, and integrating expression quantitative trait locus (eQTL) variants and their tissue-specific target genes from GTEx, Geuvadis, and other recent studies. We present these updates as HaploReg v4, and illustrate a use case of HaploReg for attention deficit hyperactivity disorder (ADHD)-associated SNPs with putative brain regulatory mechanisms. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Advanced Recyclable Media System reg-sign. Innovative technology summary report

International Nuclear Information System (INIS)

1998-12-01

The objective of the Large-Scale Demonstration Project (LSDP) is to select and demonstrate potentially beneficial technologies at the Argonne National Laboratory East's (ANL) Chicago Pile-5 (CP-5) Research Reactor. The purpose of the LSDP is to demonstrate that using innovative and improved deactivation and decommissioning (D and D) technologies from various sources can result in significant benefits, such as decreased cost and increased health and safety, as compared with baseline D and D technologies. This report describes a demonstration of the Advanced Recyclable Media System reg-sign technology which was employed by Surface Technology Systems, Inc. to remove coatings from a concrete floor. This demonstration is part of the CP-5 LSDP sponsored by the US Department of Energy (DOE) Office of Science and Technology Deactivation and Decommissioning Focus Area (DDFA). The Advanced Recyclable Media System reg-sign (ARMS) technology is an open blast technology which uses a soft recyclable media. The patented ARMS Engineered Blast Media consists of a fiber-reinforced polymer matrix which can be manufactured in various grades of abrasiveness. The fiber media can be remade and/or reused up to 20 times and can clean almost any surface (e.g., metal, wood, concrete, lead) and geometry including corners and the inside of air ducts

Dose area product evaluations with Gafchromic[reg] XR-R films and a flat-bed scanner

International Nuclear Information System (INIS)

Rampado, O; Garelli, E; Deagostini, S; Ropolo, R

2006-01-01

Gafchromic[reg] XR-R films are a useful tool to evaluate entrance skin dose in interventional radiology. Another dosimetric quantity of interest in diagnostic and interventional radiology is the dose area product (DAP). In this study, a method to evaluate DAP using Gafchromic[reg] XR-R films and a flat-bed scanner was developed and tested. Film samples were exposed to an x-ray beam of 80 kVp over a dose range of 0-10 Gy. DAP measurements with films were obtained from the digitalization of a film sample positioned over the x-ray beam window during the exposure. DAP values obtained with this method were compared for 23 cardiological interventional procedures with DAP values displayed by the equipment. The overall one-sigma dose measurement uncertainty depended on the absorbed dose, with values below 6% for doses above 1 Gy. A maximum discrepancy of 16% was found, which is of the order of the differences in the DAP measurements that may occur with different calibration procedures. Based on the results presented, after an accurate calibration procedure and a thorough inspection of the relationship between the actual dose and the direct measured quantity (net optical density or net pixel value variation), Gafchromic[reg] XR-R films can be used to assess the DAP. (note)

Dose area product evaluations with Gafchromic[reg] XR-R films and a flat-bed scanner

Energy Technology Data Exchange (ETDEWEB)

Rampado, O; Garelli, E; Deagostini, S; Ropolo, R [Struttura Complessa Fisica Sanitaria, Azienda Ospedaliera San Giovanni Battista, Corso Bramante 88, 10126 Turin (Italy)

2006-12-07

Gafchromic[reg] XR-R films are a useful tool to evaluate entrance skin dose in interventional radiology. Another dosimetric quantity of interest in diagnostic and interventional radiology is the dose area product (DAP). In this study, a method to evaluate DAP using Gafchromic[reg] XR-R films and a flat-bed scanner was developed and tested. Film samples were exposed to an x-ray beam of 80 kVp over a dose range of 0-10 Gy. DAP measurements with films were obtained from the digitalization of a film sample positioned over the x-ray beam window during the exposure. DAP values obtained with this method were compared for 23 cardiological interventional procedures with DAP values displayed by the equipment. The overall one-sigma dose measurement uncertainty depended on the absorbed dose, with values below 6% for doses above 1 Gy. A maximum discrepancy of 16% was found, which is of the order of the differences in the DAP measurements that may occur with different calibration procedures. Based on the results presented, after an accurate calibration procedure and a thorough inspection of the relationship between the actual dose and the direct measured quantity (net optical density or net pixel value variation), Gafchromic[reg] XR-R films can be used to assess the DAP. (note)

Removal of contaminants from equipment and debris and waste minimization using TechXtract{reg_sign} technology

Energy Technology Data Exchange (ETDEWEB)

Bonem, M.W. [EET, Inc., Bellaire, TX (United States)

1997-10-01

Under this Program Research and Development Agreement (PRDA), EET, Inc., is extending its proprietary TechXtract{reg_sign} chemical decontamination technology into an effective, economical, integrated contaminant removal system. This integrated system will consist of a series of decontamination baths using the TechXtract{reg_sign} chemical formulas, followed by a waste treatment process that will remove the contaminants from the spent chemicals. Sufficient decontamination will result so that materials can be released without restriction after they have been treated, even those materials that have traditionally been considered to be {open_quotes}undecontaminable.{close_quotes} The secondary liquid waste will then be treated to separate any hazardous and radioactive contaminants, so that the spent chemicals and wastewater can be discharged through conventional, permitted outlets. The TechXtract{reg_sign} technology is a unique process that chemically extracts hazardous contaminants from the surface and substrate of concrete, steel, and other solid materials. This technology has been used successfully to remove contaminants as varied as PCBs, radionuclides, heavy metals, and hazardous organics. The process` advantage over other alternatives is its effectiveness in safe and consistent extraction of subsurface contamination. TechXtract{reg_sign} is a proprietary process developed, owned, and provided by EET, Inc. The objective of the PRDA is to demonstrate on a full-scale basis an economical system for decontaminating equipment and debris, with further treatment of secondary waste streams to minimize waste volumes. Contaminants will be removed from the contaminated items to levels where they can be released for unrestricted use. The entire system will be designed with maximum flexibility and automation in mind.

Removal of contaminants from equipment and debris and waste minimization using TechXtract reg-sign technology

International Nuclear Information System (INIS)

Bonem, M.W.

1997-01-01

Under this Program Research and Development Agreement (PRDA), EET, Inc., is extending its proprietary TechXtract reg-sign chemical decontamination technology into an effective, economical, integrated contaminant removal system. This integrated system will consist of a series of decontamination baths using the TechXtract reg-sign chemical formulas, followed by a waste treatment process that will remove the contaminants from the spent chemicals. Sufficient decontamination will result so that materials can be released without restriction after they have been treated, even those materials that have traditionally been considered to be open-quotes undecontaminable.close quotes The secondary liquid waste will then be treated to separate any hazardous and radioactive contaminants, so that the spent chemicals and wastewater can be discharged through conventional, permitted outlets. The TechXtract reg-sign technology is a unique process that chemically extracts hazardous contaminants from the surface and substrate of concrete, steel, and other solid materials. This technology has been used successfully to remove contaminants as varied as PCBs, radionuclides, heavy metals, and hazardous organics. The process' advantage over other alternatives is its effectiveness in safe and consistent extraction of subsurface contamination. TechXtract reg-sign is a proprietary process developed, owned, and provided by EET, Inc. The objective of the PRDA is to demonstrate on a full-scale basis an economical system for decontaminating equipment and debris, with further treatment of secondary waste streams to minimize waste volumes. Contaminants will be removed from the contaminated items to levels where they can be released for unrestricted use. The entire system will be designed with maximum flexibility and automation in mind

RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity

Directory of Open Access Journals (Sweden)

Elias Abdou

2017-05-01

Full Text Available For aerobic human pathogens, adaptation to hypoxia is a critical factor for the establishment of persistent infections, as oxygen availability is low inside the host. The two-component system RegB/A of Brucella suis plays a central role in the control of respiratory systems adapted to oxygen deficiency, and in persistence in vivo. Using an original “in vitro model of persistence” consisting in gradual oxygen depletion, we compared transcriptomes and proteomes of wild-type and ΔregA strains to identify the RegA-regulon potentially involved in the set-up of persistence. Consecutive to oxygen consumption resulting in growth arrest, 12% of the genes in B. suis were potentially controlled directly or indirectly by RegA, among which numerous transcriptional regulators were up-regulated. In contrast, genes or proteins involved in envelope biogenesis and in cellular division were repressed, suggesting a possible role for RegA in the set-up of a non-proliferative persistence state. Importantly, the greatest number of the RegA-repressed genes and proteins, including aceA encoding the functional IsoCitrate Lyase (ICL, were involved in energy production. A potential consequence of this RegA impact may be the slowing-down of the central metabolism as B. suis progressively enters into persistence. Moreover, ICL is an essential determinant of pathogenesis and long-term interactions with the host, as demonstrated by the strict dependence of B. suis on ICL activity for multiplication and persistence during in vivo infection. RegA regulates gene or protein expression of all functional groups, which is why RegA is a key regulator of B. suis in adaptation to oxygen depletion. This function may contribute to the constraint of bacterial growth, typical of chronic infection. Oxygen-dependent activation of two-component systems that control persistence regulons, shared by several aerobic human pathogens, has not been studied in Brucella sp. before. This work

The Determination of a Useful Frequency for Refreshing Memories for Procedures among a Collegiate Population.

Science.gov (United States)

Zambon, Franco

This study sought to determine a useful frequency for refreshing students' memories of complex procedures that involved a formal computer language. Students were required to execute the Microsoft Disc Operating System (MS-DOS) commands for "copy,""backup," and "restore." A total of 126 college students enrolled in six…

Control of CydB and GltA1 expression by the SenX3 RegX3 two component regulatory system of Mycobacterium tuberculosis.

Directory of Open Access Journals (Sweden)

Gretta Roberts

Full Text Available Two component regulatory systems are used widely by bacteria to coordinate changes in global gene expression profiles in response to environmental signals. The SenX3-RegX3 two component system of Mycobacterium tuberculosis has previously been shown to play a role in virulence and phosphate-responsive control of gene expression. We demonstrate that expression of SenX3-RegX3 is controlled in response to growth conditions, although the absolute changes are small. Global gene expression profiling of a RegX3 deletion strain and wild-type strain in different culture conditions (static, microaerobic, anaerobic, as well as in an over-expressing strain identified a number of genes with changed expression patterns. Among those were genes previously identified as differentially regulated in aerobic culture, including ald (encoding alanine dehydrogenase cyd,encoding a subunit of the cytochrome D ubiquinol oxidase, and gltA1, encoding a citrate synthase. Promoter activity in the upstream regions of both cydB and gltA1 was altered in the RegX3 deletion strain. DNA-binding assays confirmed that RegX3 binds to the promoter regions of ald, cydB and gltA1 in a phosphorylation-dependent manner. Taken together these data suggest a direct role for the SenX-RegX3 system in modulating expression of aerobic respiration, in addition to its role during phosphate limitation.

RELACIÓN ENTRE LA ANEMIA GESTACIONAL EN LA ALTURA DETECTADO EN EL I TRIMESTRE Y LOS RESULTADOS PERINATALES. HOSPITAL DANIEL ALCIDES CARRIÓN PASCO. AÑO 2015

OpenAIRE

Rios Bernardo, Cledy Ruperta

2017-01-01

Objetivo: Determinar la relación entre la anemia gestacional en la altura detectado en el I trimestre y los resultados perinatales. Hospital Daniel Alcides Carrión – Pasco. Año 2015. Método de Estudio: Deductivo; diseño descriptivo de nivel relacional, tipo retrospectivo, de cohorte transversal; la población estudiada estuvo constituida por 44 gestantes. Resultados: 1. La edad más frecuente 18 años, el 86% procedente de la zonas distritales, con estudios de secundaria en el 64% y 73% co...

Bistable electroactive polymer for refreshable Braille display with improved actuation stability

Science.gov (United States)

Niu, Xiaofan; Brochu, Paul; Stoyanov, Hristiyan; Yun, Sung Ryul; Pei, Qibing

2012-04-01

Poly(t-butyl acrylate) is a bistable electroactive polymer (BSEP) capable of rigid-to-rigid actuation. The BSEP combines the large-strain actuation of dielectric elastomers with shape memory property. We have introduced a material approach to overcome pull-in instability in poly(t-butyl acrylate) that significantly improves the actuation lifetime at strains greater than 100%. Refreshable Braille display devices with size of a smartphone screen have been fabricated to manifest a potential application of the BSEP. We will report the testing results of the devices by a Braille user.

Simulation and spatiotemporal pattern of air temperature and precipitation in Eastern Central Asia using RegCM.

Science.gov (United States)

Meng, Xianyong; Long, Aihua; Wu, Yiping; Yin, Gang; Wang, Hao; Ji, Xiaonan

2018-02-26

Central Asia is a region that has a large land mass, yet meteorological stations in this area are relatively scarce. To address this data issues, in this study, we selected two reanalysis datasets (the ERA40 and NCEP/NCAR) and downscaled them to 40 × 40 km using RegCM. Then three gridded datasets (the CRU, APHRO, and WM) that were extrapolated from the observations of Central Asian meteorological stations to evaluate the performance of RegCM and analyze the spatiotemporal distribution of precipitation and air temperature. We found that since the 1960s, the air temperature in Xinjiang shows an increasing trend and the distribution of precipitation in the Tianshan area is quite complex. The precipitation is increasing in the south of the Tianshan Mountains (Southern Xinjiang, SX) and decreasing in the mountainous areas. The CRU and WM data indicate that precipitation in the north of the Tianshan Mountains (Northern Xinjiang, NX) is increasing, while the APHRO data show an opposite trend. The downscaled results from RegCM are generally consistent with the extrapolated gridded datasets in terms of the spatiotemporal patterns. We believe that our results can provide useful information in developing a regional climate model in Central Asia where meteorological stations are scarce.

Realization of an accelerator for environmental refreshment in case of soil; Fukyugata kasokuki ni yoru kankyo sosei eno koka

Energy Technology Data Exchange (ETDEWEB)

Isogai, H [Electrotechnical Laboratory, Tsukuba (Japan)

1997-11-25

Learning from a history of the earth of ancient times, the paper studies effects of refreshing environment and soil or making them natural and harmless mostly using primitive bacteria, and develops element technology which is industrially accelerating. The spread type accelerator working only by solar energy was installed and operated for experiment. As indices of refreshment effects, a study was comparatively made between a sugar degree of sweet potato and a yield shown in the number of potatotimesunit weight. An EM propagation garbage layer is formed, and the two sections were installed of a site of the actual installation of the spread type accelerator and a site naturally left alone. Other effects of weather, temperature and humidity which are external factors and general fertilization are offset as common modes, and a consideration was so made that only refreshment effects of primitive bacteria can be relatively compared. Acceleration effects in using accelerator for growing sweet potato could be quantitatively confirmed. As to sugar degree, because the last study was made in the beginning of summer, the underground temperature was high enough. Even only EM effects were fully effective. This time, the weather was much colder, and it was found to be a must to use accelerator. 2 figs.

Topical safety analysis report for the transportation of the NUHOMS{reg_sign} dry shielded canister. Volume 1

Energy Technology Data Exchange (ETDEWEB)

None

1993-08-01

This Topical Safety Analysis Report (SAR) describes the design and the generic transportation licensing basis for utilizing the NUTECH HORIZONTAL MODULAR STORAGE (NUHOMS{reg_sign}) system dry shielded canister (DSC) containing twenty-four pressurized water reactor (PWR) spent fuel assemblies (SFA) in conjunction with a conceptually designed Transportation Cask. This SAR documents the design qualification of the NUHOMS{reg_sign} DSC as an integral part of a 10CFR71 Fissile Material Class III, Type B(M) Transportation Package. The package consists of the canister and a conceptual transportation cask (NUHOMS{reg_sign} Transportation Cask) with impact limiters. Engineering analysis is performed for the canister to confirm that the existing canister design complies with 10CFR71 transportation requirements. Evaluations and/or analyses is performed for criticality safety, shielding, structural, and thermal performance. Detailed engineering analysis for the transportation cask will be submitted in a future SAR requesting 10CFR71 certification of the complete waste package. Transportation operational considerations describe various operational aspects of the canister/transportation cask system. operational sequences are developed for canister transfer from storage to the transportation cask and interfaces with the cask auxiliary equipment for on- and off-site transport.

REG4 Is Highly Expressed in Mucinous Ovarian Cancer: A Potential Novel Serum Biomarker.

Directory of Open Access Journals (Sweden)

Laura Lehtinen

Full Text Available Preoperative diagnostics of ovarian neoplasms rely on ultrasound imaging and the serum biomarkers CA125 and HE4. However, these markers may be elevated in non-neoplastic conditions and may fail to identify most non-serous epithelial cancer subtypes. The objective of this study was to identify histotype-specific serum biomarkers for mucinous ovarian cancer. The candidate genes with mucinous histotype specific expression profile were identified from publicly available gene-expression databases and further in silico data mining was performed utilizing the MediSapiens database. Candidate biomarker validation was done using qRT-PCR, western blotting and immunohistochemical staining of tumor tissue microarrays. The expression level of the candidate gene in serum was compared to the serum CA125 and HE4 levels in a patient cohort of prospectively collected advanced ovarian cancer. Database searches identified REG4 as a potential biomarker with specificity for the mucinous ovarian cancer subtype. The specific expression within epithelial ovarian tumors was further confirmed by mRNA analysis. Immunohistochemical staining of ovarian tumor tissue arrays showed distinctive cytoplasmic expression pattern only in mucinous carcinomas and suggested differential expression between benign and malignant mucinous neoplasms. Finally, an ELISA based serum biomarker assay demonstrated increased expression only in patients with mucinous ovarian cancer. This study identifies REG4 as a potential serum biomarker for histotype-specific detection of mucinous ovarian cancer and suggests serum REG4 measurement as a non-invasive diagnostic tool for postoperative follow-up of patients with mucinous ovarian cancer.

Descriptions of wells penetrating the Wanapum Basalt Formation in the Pasco Basin area, Washington. Volume 1. Well records and driller's logs for wells in Townships 7 north through 12 north

International Nuclear Information System (INIS)

Summers, W.K.; Weber, P.A.

1978-04-01

About 7000 wells have been drilled in the Pasco Basin, of which about 4000 are on the Hanford Reservation. Information on these wells ranges from depth of the well to a complete driller's log and casing record. This report presents the data available on 268 wells that were drilled into basalts deeper than the Mabton Interbed, or its equivalent. Thus, these are the wells which are open in basalt flows that are at least 15 million years old. 3 figures, 2 tables

Uma proposta de dicionário de regência verbal português-espanhol para aprendizes brasileiros de espanhol

OpenAIRE

Aline Noimann

2015-01-01

Esta tese apresenta as bases para a elaboração de um protótipo de dicionário de regência verbal para alunos brasileiros estudantes de Espanhol como Língua Estrangeira e se insere na área de Estudos da Linguagem, mais especificamente na linha de pesquisa Lexicografia, Terminologia e Tradução: relações textuais. O objetivo geral desta tese é o de estabelecer os princípios e o protótipo para a elaboração de um dicionário de regência verbal Português-Espanhol para alunos brasileiros estudantes de...

77 FR 11997 - Consumer and Governmental Affairs Bureau Seeks To Refresh the Record Regarding Misuse of Internet...

Science.gov (United States)

2012-02-28

... and other electronic messaging services, now serve as adequate or preferred alternatives to IP Relay... Relay Service AGENCY: Federal Communications Commission. ACTION: Proposed rule. SUMMARY: In this... refresh the record regarding misuse of Internet Protocol relay service. Further comments are requested to...

Regional climate projection based on RCP scenarios in the CORDEX East Asia Domain Using RegCM4

Science.gov (United States)

Suh, M. S.; Oh, S. G.; Cha, D. H.; Kang, H. S.

2012-04-01

Regional climate projection data is essential to the adaptation and risk management for the expected climate change. In this stduy, we reproduced regional climate over CORDEX East Asia for 72 years from 1979 to 2050 with 50-km resolution using the latest regional climate model version 4, RegCM4, driven by HadGEM2-AO with about 135-km resolution under Intergovernmental Panel on Climate Change (IPCC) Representative Concentration Pathway (RCP) 8.5/4.5. Simulation skills of RegCM4 for the present climate (1980-2005, spin up time: 1979) over CORDEX East Asia are evaluated with CRU-TS (Climate Research Unit Time-Series) 3.0 and GPCP (Global Precipitation Climatology Project). And KMA ground observation data are also used for the detailed assessment of RegCM4 over South Korea. The evaluation results showed that RegCM4 reasonalbly simulated the spatial distribution, and inter-annual and seasonal variations of surface air temperature. However, it showed a non-negligible systemartic biases in the precipitation. In particular, the rainband accompanied by the seasonal march of East Asian summer monsoon was simulated too southward, below 30° N comparing to the GPCP. As a reulst, summer precipitation over South Korea and Japan island was significantly underestimated. Under RCP8.5 (RCP4.5) scenario, annual mean temperature over the CORDEX East Asia is expected to increase by + 1.6 oC(+1.4oC) above the present level (1980-2005) by the end of the future simulation period. Most of the regions (South-Korea, South-China, North-China, India, Japan, Mongolia) show the increaseing trend of surface air temperature. On the other hand, the future changes of precipitation are not systemaic at the most of regions and seasons. More detailed results including projected regional climate change will be discussed in the presentation.

Comparative Study of a Real-Time PCR Assay Targeting senX3-regX3 versus Other Molecular Strategies Commonly Used in the Diagnosis of Tuberculosis.

Directory of Open Access Journals (Sweden)

Rocio Sanjuan-Jimenez

Full Text Available Nucleic acid amplification tests are increasingly used for the rapid diagnosis of tuberculosis. We undertook a comparative study of the efficiency and diagnostic yield of a real-time PCR senX3-regX3 based assay versus the classical IS6110 target and the new commercial methods.This single-blind prospective comparative study included 145 consecutive samples: 76 from patients with culture-confirmed tuberculosis (86.8% pulmonary and 13.2% extrapulmonary tuberculosis: 48.7% smear-positive and 51.3% smear-negative and 69 control samples (24 from patients diagnosed with non-tuberculous mycobacteria infections and 45 from patients with suspected tuberculosis which was eventually ruled out. All samples were tested by two CE-marked assays (Xpert®MTB/RIF and AnyplexTM plus MTB/NTM and two in-house assays targeting senX3-regX3 and the IS6110 gene.The detection limit ranged from 1.00E+01 fg for Anyplex, senX3-regX3 and IS6110 to 1.00E+04 fg for Xpert. All three Xpert, senX3-regX3 and IS6110 assays detected all 37 smear-positive cases. Conversely, Anyplex was positive in 34 (91.9% smear-positive cases. In patients with smear-negative tuberculosis, differences were observed between the assays; Xpert detected 22 (56.41% of the 39 smear-negative samples, Anyplex 24 (61.53%, senX3-regX3 28 (71.79% and IS6110 35 (89.74%. Xpert and senX3-regX3 were negative in all control samples; however, the false positive rate was 8.7% and 13% for Anyplex and IS6110, respectively. The overall sensitivity was 77.6%, 85.7%, 77.3% and 94.7% and the specificity was 100%, 100%, 90.8% and 87.0% for the Xpert, senX3-regX3, Anyplex and IS6110 assays, respectively.Real-time PCR assays targeting IS6110 lack the desired specificity. The Xpert MTB/RIF and in-house senX3-regX3 assays are both sensitive and specific for the detection of MTBC in both pulmonary and extrapulmonary samples. Therefore, the real time PCR senX3-regX3 based assay could be a useful and complementary tool in the

Math for scientists refreshing the essentials

CERN Document Server

Maurits, Natasha

2017-01-01

Accessible and comprehensive, this guide is an indispensable tool for anyone in the sciences – new and established researchers, students and scientists – looking either to refresh their math skills or to prepare for the broad range of math, statistical and data-related challenges they are likely to encounter in their work or studies. In addition to helping scientists improve their knowledge of key mathematical concepts, this unique book will help readers: ·                     Read mathematical symbols ·                     Understand formulas, data or statistical information ·                     Determine medication equivalents ·                     Analyze neuroimaging  Mathematical concepts are presented alongside illustrative and useful real-world scien­tific examples and are further clarified through practical pen-and-paper exercises. Whether you are a student encountering high-level mathematics in your research or...

Remediation of groundwater containing radionuclides and heavy metals using ion exchange and the AlgaSORB reg-sign biosorbent system

International Nuclear Information System (INIS)

Feiler, H.D.; Darnall, D.W.

1991-01-01

Bio-Recovery Systems, Inc. (BRS) studied the application of an immobilized algal biomass, termed AlgaSORB reg-sign, which has high affinity for heavy metal ions to DOE-contaminated groundwaters. The material can be packed into columns similar to commercial ion exchange resins. Dilute solutions containing heavy metals are passed through columns where metals are absorbed by the AlgaSORB reg-sign resins. Once saturated, metal ions can be stripped from the resin biomass in a highly concentrated solution. Groundwaters contaminated with heavy metal ions from three different Department of Energy (DOE) sites: Savannah River, Hanford and the Oak Ridge Y-12 Plant were studied. The objective was to perform bench-scale treatability studies to establish treatment protocols and to optimize an AlgaSORB reg-sign/ion exchange technology system to remove and recover toxic metal ions from these contaminated groundwaters. The specialty ion exchange/AlgaSORB reg-sign resins tested in these studies show promise for selectively removing chromium, mercury and uranium from contaminated groundwater at DOE sites. The data show that effluents which satisfy the allowable metal ion limits are possible and most likely achievable. The use of these highly selective resins also offer advantages in terms of cost/benefit, risk and scheduling. Their high selectivity allows for high capacity and opportunities for recovery of removed constituents due to high pollutant concentration possible (3 to 4 orders of magnitude). Ion exchange is a proven technology which is easily automated and can be cost-effective, depending on the application

Design ampersand operational experience of the NUHOMS reg-sign-24P spent fuel storage system

International Nuclear Information System (INIS)

McConaghy, W.J.; Lehnert, R.A.; Rasmussen, R.W.

1991-01-01

The NUHOMS reg-sign Spent Fuel Storage System provides a safe and economical method for the dry storage of spent fuel assemblies either at an at-reactor Independent Spent Fuel Storage Installation (ISFSI) or at a centralized away-from-reactor (AFR) storage facility. The system consists of three major safety related components: a dry shielded canister (DSC) which provides a high integrity containment boundary and a controlled storage environment for the fuel; a reinforced concrete horizontal storage module (HSM) which houses the stored DSC and provides radiation shielding, protection against natural phenomena, and an efficient means for decay heat removal; and a transfer cask which provides for the safe shielded transfer of the DSC from the plant spent fuel pool to the HSM. The NUHOMS reg-sign system is designed and licensed to the requirements of 10 CFR 72 and ANS/ANSI 57.9 for ISFSIs

Expression of Gast, Cckbr, Reg1α genes in rat duodenal epithelial cells upon long-term gastric hypoacidity and after a multiprobiotic administration

Directory of Open Access Journals (Sweden)

Dranitsina A. S.

2014-11-01

Full Text Available Aim. Determination of the Cckbr, Gast and Reg1α genes expression in rat duodenal epithelial cells upon long- term hypoacidity and with the administration of the multiprobiotic Symbiter. Methods. The experiments were carried out on white non-strain male rats. The hypoacidic state was induced through intraperitoneal injection of omeprazole for 28 days. The level of genes expression was determined by semi-quantitative analysis with RT-PCR Results. The elevation of mRNA levels of the Cckbr and Gast genes in rat duodenal villus and crypt epitheliocytes, the increased expression of the Reg1A gene in crypt epithelial cells were shown as well as the appearance of the Reg1a gene expression in villus epitheliocytes upon hypoacidic conditions were shown. The content of mRNAs of the above mentioned genes decreased or remained at the control level upon the treatment of hypoacidic rats with the multiprobiotic Symbiter. Conclusions. Long-term gastric hypoacidity is accompanied by the changes in expression of the Cckbr, Gast and Reg1a genes in rat duodenum, whereas upon administration of the multiprobiotic Symbiter the pattern of studied gene expression did not changed in the most cases.

DC-transport properties of QMG(reg sign) current-limiting elements; QMG(reg sign) genryusoshi no chokuryutuden tokusei

Energy Technology Data Exchange (ETDEWEB)

Morita, M.; Tokunaga, Y. [Nippon Steel Corporation, Tokyo (Japan); Miura, D.; Ito, D. [Tokyo Metroporitan University, Tokyo (Japan)

1999-11-25

The V-I properties of YBCO bulk superconductor (QMG(reg sign) :YBa{sub 2}Cu{sub 3}O{sub 7-x} single-crystal containing Y{sub 2}BaCuO{sub 5} particles) were measured using a single rectangular pule current at 77 and 87 K to obtain basic data for super-normal transition. Because of its high J{sub c} property, QMG is a promising bulk material for resistive-type HTC-FCL application. I-shaped QMG rods having cross sections of 0.5 x 1.0 mm were prepared to measure voltage due to pule current. The plots of ln V vs ln I yielded a straight line with a gradient ranging from 5 to 7. By changing the amplitude and length of pulses, the time from the start of sending electricity till the occurrence of quenching was obtained for various amplitudes of pulse current. In this experiment, it is considered that quenching did not occur in the whole rod but only in a small part of it. (author)

Clinical experience with the MammoSite[reg] radiation therapy system for brachytherapy of breast cancer: Results from an international phase II trial

International Nuclear Information System (INIS)

Niehoff, Peter; Polgar, Csaba; Ostertag, Horst; Major, Tibor; Sulyok, Zoltan; Kimmig, Bernhard; Kovacs, Gyoergy

2006-01-01

Background and purpose: In a prospective multi-center phase II trial, we investigated the MammoSite[reg] Radiation Therapy System, a new device for delivering intracavitary brachytherapy following breast conserving surgery. The MammoSite[reg] is a dual lumen, closed ended catheter with a small, spherical inflatable balloon and a port for connecting a remote afterloader to the central lumen. We analyzed the surgical procedure and placement of the MammoSite[reg], treatment planning and radiation delivery complications and cosmesis, as well the comfort for the patients. Patients and methods: Between 2002 and 2004 a total of 32 patients (pts) were implanted using the MammoSite[reg]. The reference isodose was defined 1 cm from the balloon surface. We analyzed the post-implant anatomic position of the applicator and the geometric form of the balloon via ultrasound, CT and X-ray, related side effects, cosmetic outcome and patient quality of life. Results: Twenty-three out of 32 patients (72%) were eligible for MammoSite[reg] intracavitary brachytherapy. Twenty-eight percentage had to be excluded because of different reasons. Eleven patients were treated with primary brachytherapy with a total dose of 34 Gy (2x3.4 Gy) and 12 had a boost with a mean dose of 13.3 Gy (range: 7.5-15 Gy; 2x2.5 Gy) combined with EBRT and doses ranged between 46 and 50 Gy. In three cases a balloon rupture occurred. We observed two abscesses within 3 months of implantation and serious seroma development in 10 patients (39%). Skin related side effects were erythema in 21 patients (91%), hyperpigmentation in 13 patients (56%) and teleangiectasia in six patients (26%) after mean follow-up 20 months. Conclusions: The MammoSite[reg] Radiation Therapy System is a feasible treatment modality for intracavitary brachytherapy of breast cancer after breast conserving surgery. The advantage of the system is only one applicator is necessary for the delivery of a fractionated radiotherapy. In addition, patient

BagReg: Protein inference through machine learning.

Science.gov (United States)

Zhao, Can; Liu, Dao; Teng, Ben; He, Zengyou

2015-08-01

Protein inference from the identified peptides is of primary importance in the shotgun proteomics. The target of protein inference is to identify whether each candidate protein is truly present in the sample. To date, many computational methods have been proposed to solve this problem. However, there is still no method that can fully utilize the information hidden in the input data. In this article, we propose a learning-based method named BagReg for protein inference. The method firstly artificially extracts five features from the input data, and then chooses each feature as the class feature to separately build models to predict the presence probabilities of proteins. Finally, the weak results from five prediction models are aggregated to obtain the final result. We test our method on six public available data sets. The experimental results show that our method is superior to the state-of-the-art protein inference algorithms. Copyright © 2015 Elsevier Ltd. All rights reserved.

Photothermally Driven Refreshable Microactuators Based on Graphene Oxide Doped Paraffin.

Science.gov (United States)

Hou, Sichao; Wang, Miao; Guo, Shouwu; Su, Ming

2017-08-09

Actuators based on phase change materials (paraffin) can simultaneously produce large stroke length and large force due to thermal expansion, but the low thermal conductivity of paraffin requires high power input and long actuation time. The graphene oxide (GO) doped paraffin dynamic actuator addresses the key challenges in the design of thermal phase change actuators: Thermal conductivity and light absorbing are increased, and the response time is reduced compared to the standard phase change actuator designed with metal heating resistors. The thermal properties of GO-paraffin composites with varied loading amount are characterized to confirm the optimal loading amount of 1.0%. A multicell phase change actuator was integrated into a digital micromirror controlled optical system. A series of photothermally driven refreshable patterns were generated and confirmed with infrared imaging.

The Development of Memory Maintenance: Children's Use of Phonological Rehearsal and Attentional Refreshment in Working Memory Tasks

Science.gov (United States)

Tam, Helen; Jarrold, Christopher; Baddeley, Alan D.; Sabatos-DeVito, Maura

2010-01-01

Past research suggests that children begin to phonologically rehearse at around 7 years of age. Less is known regarding the development of refreshment, an attention-based maintenance mechanism. Therefore, the use of these two maintenance methods by 6- and 8-year-olds was assessed using memory span tasks that varied in their opportunities for…

The development of memory maintenance: children's use of phonological rehearsal and attentional refreshment in working memory tasks.

Science.gov (United States)

Tam, Helen; Jarrold, Christopher; Baddeley, Alan D; Sabatos-DeVito, Maura

2010-11-01

Past research suggests that children begin to phonologically rehearse at around 7 years of age. Less is known regarding the development of refreshment, an attention-based maintenance mechanism. Therefore, the use of these two maintenance methods by 6- and 8-year-olds was assessed using memory span tasks that varied in their opportunities for maintenance activity. Experiment 1 showed that nonverbal processing impaired both groups' performance to similar extents. Experiment 2 employed phonologically similar or dissimilar memory items and compared the effects of verbal versus nonverbal processing on recall. Both groups showed evidence of phonological maintenance under nonverbal processing but not under verbal processing. Furthermore, nonverbal processing again impaired recall. Verbal processing was also more detrimental to performance in 8-year-olds than in 6-year-olds. Together, the results suggest that nonverbal processing impairs recall by obstructing refreshment and that developmental change in maintenance between 6 and 8 years of age consists primarily of an increase in phonological rehearsal. Copyright (c) 2010 Elsevier Inc. All rights reserved.

Identification of Columbia River basalt flows from deep cores in the Pasco Basin based on trace element abundances

International Nuclear Information System (INIS)

Fruchter, J.S.; Rancitelli, L.A.

1976-01-01

Samples of basalt from three deep core holes drilled in the Pasco Basin, Washington (DDH-3, DH-4, DH-5) were analyzed by instrumental neutron activation (INAA) for up to fifteen trace and major elements. These analyses were used to assign each basalt flow to one of a series of previously defined chemical types of the Columbia River Basalt Group. All of the flows except the two flows at the bottom of well DDH-3 were clearly assignable to one of the defined chemical types. These two flows apparently represent new, as yet undefined chemical types. Average values and standard deviations for compositions of each of the chemical types found in the three wells are presented along with two-element variation diagrams for the geochemically important pair La-Cr, La-Fe, La-Th and La-Sc. The assignment of the flows to known chemical types accomplished in this study was very helpful in relating the basalts in the core holes to stratigraphically defined basalt flows in surface sections. A correlation diagram relating the flows in the core holes to one another on the basis of chemical type is presented

A Saccharomyces cerevisiae mitochondrial DNA fragment activates Reg1p-dependent glucose-repressible transcription in the nucleus.

Science.gov (United States)

Santangelo, G M; Tornow, J

1997-12-01

As part of an effort to identify random carbon-source-regulated promoters in the Saccharomyces cerevisiae genome, we discovered that a mitochondrial DNA fragment is capable of directing glucose-repressible expression of a reporter gene. This fragment (CR24) originated from the mitochondrial genome adjacent to a transcription initiation site. Mutational analyses identified a GC cluster within the fragment that is required for transcriptional induction. Repression of nuclear CR24-driven transcription required Reg1p, indicating that this mitochondrially derived promoter is a member of a large group of glucose-repressible nuclear promoters that are similarly regulated by Reg1p. In vivo and in vitro binding assays indicated the presence of factors, located within the nucleus and the mitochondria, that bind to the GC cluster. One or more of these factors may provide a regulatory link between the nucleus and mitochondria.

Distinct cell clusters touching islet cells induce islet cell replication in association with over-expression of Regenerating Gene (REG protein in fulminant type 1 diabetes.

Directory of Open Access Journals (Sweden)

Kaoru Aida

Full Text Available BACKGROUND: Pancreatic islet endocrine cell-supporting architectures, including islet encapsulating basement membranes (BMs, extracellular matrix (ECM, and possible cell clusters, are unclear. PROCEDURES: The architectures around islet cell clusters, including BMs, ECM, and pancreatic acinar-like cell clusters, were studied in the non-diabetic state and in the inflamed milieu of fulminant type 1 diabetes in humans. RESULT: Immunohistochemical and electron microscopy analyses demonstrated that human islet cell clusters and acinar-like cell clusters adhere directly to each other with desmosomal structures and coated-pit-like structures between the two cell clusters. The two cell-clusters are encapsulated by a continuous capsule composed of common BMs/ECM. The acinar-like cell clusters have vesicles containing regenerating (REG Iα protein. The vesicles containing REG Iα protein are directly secreted to islet cells. In the inflamed milieu of fulminant type 1 diabetes, the acinar-like cell clusters over-expressed REG Iα protein. Islet endocrine cells, including beta-cells and non-beta cells, which were packed with the acinar-like cell clusters, show self-replication with a markedly increased number of Ki67-positive cells. CONCLUSION: The acinar-like cell clusters touching islet endocrine cells are distinct, because the cell clusters are packed with pancreatic islet clusters and surrounded by common BMs/ECM. Furthermore, the acinar-like cell clusters express REG Iα protein and secrete directly to neighboring islet endocrine cells in the non-diabetic state, and the cell clusters over-express REG Iα in the inflamed milieu of fulminant type 1 diabetes with marked self-replication of islet cells.

Effects of reducing blood pressure on renal outcomes in patients with type 2 diabetes: Focus on SGLT2 inhibitors and EMPA-REG OUTCOME.

Science.gov (United States)

Scheen, A J; Delanaye, P

2017-04-01

Empagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, has enabled remarkable reductions in cardiovascular and all-cause mortality as well as in renal outcomes in patients with type 2 diabetes (T2D) and a history of cardiovascular disease in the EMPA-REG OUTCOME. These results have been attributed to haemodynamic rather than metabolic effects, in part due to the osmotic/diuretic action of empagliflozin and the reduction in arterial blood pressure (BP). The present narrative review includes the results of meta-analyses of trials evaluating the effects on renal outcomes of lowering BP in patients with T2D, with a special focus on the influence of baseline and achieved systolic BP, and compares the renal outcome results of the EMPA-REG OUTCOME with those of other major trials with inhibitors of the renin-angiotensin system in patients with T2D and the preliminary findings with other SGLT2 inhibitors, and also evaluates post hoc analyses from the EMPA-REG OUTCOME of special interest as regards the BP-lowering hypothesis and renal function. While systemic BP reduction associated to empagliflozin therapy may have contributed to the renal benefits reported in EMPA-REG OUTCOME, other local mechanisms related to kidney homoeostasis most probably also played a role in the overall protection observed in the trial. Copyright © 2017. Published by Elsevier Masson SAS.

NordREG report on the price peaks in the Nordic wholesale market during winter 2009-2010. Final report

Energy Technology Data Exchange (ETDEWEB)

2011-01-15

In winter 2009-2010, prices peaked on three days. The high prices that were experienced in the majority of the Nord Pool Spot price areas initiated a study on the reasons that led to the price spikes and on the possible measures to develop the Nordic market arrangements to avoid such situations in the future. The analysis of the winter 2009-2010 events revealed that there were a number of primary causes for the occurrence of the price peaks and no single individual cause could be pinpointed to bear the key responsibility. The fact that the weather was cold all over the Nordic area in conjunction with the low availability for the Swedish nuclear generation capacity, however, could be indicated as the key underlying causes. The analysis also showed that the way the Nordic transmission capacity is allocated can be listed as an additional factor complementing to the occurrence of the price peaks. Thus, NordREG concluded that a review of the methods of calculating and allocating transmission capacity for the market should be carried out. As a part of this, an analysis that addresses the delimitation of bidding areas and maintenance planning of the transmission network infrastructure should be prepared as well. The flexibility on the demand side has not been very large in the Nordic region. However, the background study prepared by Gaia Consulting showed that even small degree of increased price elasticity could substantially cut the price peaks. This could be seen as an improvement potential of the trading system reflecting the present inability of the market participants to react on the price signals the market place provides. Therefore, NordREG sees that facilitating the appearance of a real price elastic behaviour of the users of electricity can be regarded as one of the key fixes for the problem. Furthermore, NordREG proposes that a consultancy study on how to promote demand flexibility in the Nordic market in a coherent way should be prepared. A further area for

Projecte d’una instal•lació solar fotovoltaica per a un sistema de bombes de reg

OpenAIRE

Batllori Alvarez, Eduard

2009-01-01

Instal.lació d’una explotació agrícola amb funcionament per energia solar fotovoltaica a Torregrossa (Tarragona). Disseny i definició de les parts necessàries que conformaran la instal•lació solar fotovoltaica que subministrarà energia elèctrica a les bombes de reg

Projecte d’una instal•lació solar fotovoltaica per a un sistema de bombes de reg

OpenAIRE

Batllori Alvarez, Eduard

2010-01-01

Instal.lació d’una explotació agrícola amb funcionament per energia solar fotovoltaica a Torregrossa (Tarragona). Disseny i definició de les parts necessàries que conformaran la instal•lació solar fotovoltaica que subministrarà energia elèctrica a les bombes de reg

Evaluation of Boulder, CO, SmartRegs Ordinance and Better Buildings Program

Energy Technology Data Exchange (ETDEWEB)

Arena, L.; Vijayakumar, G.

2012-04-01

Under the SmartRegs ordinance in the city of Boulder, Colorado, all rental properties in the city must achieve an energy efficiency level comparable to a HERS Index of approximately 120 points or lower by the year 2019. The City of Boulder received a $12 million grant from the DOE's Better Buildings initiative to create and incentivize their EnergySmart Program. In this report, the Consortium for Advanced Residential Buildings (CARB) describes its work with the program, including energy audits of rental properties, developing training programs for insulators and inspectors, and conducting interviews with property owners.

Evaluation of Boulder, CO,SmartRegs Ordinance and Better Buildings Program

Energy Technology Data Exchange (ETDEWEB)

Arena, L. [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States); Vijayakumar, G. [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States)

2012-04-01

Under the SmartRegs ordinance in the city of Boulder, Colorado, all rental properties in the city must achieve an energy efficiency level comparable to a HERS Index of approximately 120 points or lower by the year 2019. The City of Boulder received a $12 million grant from the DOE’s Better Buildings initiative to create and incentivize their EnergySmart Program. In this report, the Consortium for Advanced Residential Buildings (CARB) describes its work with the program, including energy audits of rental properties, developing training programs for insulators and inspectors, and conducting interviews with property owners.

Best convective parameterization scheme within RegCM4 to downscale CMIP5 multi-model data for the CORDEX-MENA/Arab domain

Science.gov (United States)

Almazroui, Mansour; Islam, Md. Nazrul; Al-Khalaf, A. K.; Saeed, Fahad

2016-05-01

A suitable convective parameterization scheme within Regional Climate Model version 4.3.4 (RegCM4) developed by the Abdus Salam International Centre for Theoretical Physics, Trieste, Italy, is investigated through 12 sensitivity runs for the period 2000-2010. RegCM4 is driven with European Centre for Medium-Range Weather Forecasts (ECMWF) ERA-Interim 6-hourly boundary condition fields for the CORDEX-MENA/Arab domain. Besides ERA-Interim lateral boundary conditions data, the Climatic Research Unit (CRU) data is also used to assess the performance of RegCM4. Different statistical measures are taken into consideration in assessing model performance for 11 sub-domains throughout the analysis domain, out of which 7 (4) sub-domains give drier (wetter) conditions for the area of interest. There is no common best option for the simulation of both rainfall and temperature (with lowest bias); however, one option each for temperature and rainfall has been found to be superior among the 12 options investigated in this study. These best options for the two variables vary from region to region as well. Overall, RegCM4 simulates large pressure and water vapor values along with lower wind speeds compared to the driving fields, which are the key sources of bias in simulating rainfall and temperature. Based on the climatic characteristics of most of the Arab countries located within the study domain, the drier sub-domains are given priority in the selection of a suitable convective scheme, albeit with a compromise for both rainfall and temperature simulations. The most suitable option Grell over Land and Emanuel over Ocean in wet (GLEO wet) delivers a rainfall wet bias of 2.96 % and a temperature cold bias of 0.26 °C, compared to CRU data. An ensemble derived from all 12 runs provides unsatisfactory results for rainfall (28.92 %) and temperature (-0.54 °C) bias in the drier region because some options highly overestimate rainfall (reaching up to 200 %) and underestimate

Comparative effects of split Orimulsion reg-sign, fuel oil number-sign 6 and Lago Medio Crude oil over functional variables of an estuarine community

International Nuclear Information System (INIS)

Quilici, A.; Rodriguez-Grau, J.; Vasquez, P.; Infante, C.; Schiazza, J. La; Briceno, H.; Pereira, N.

1995-01-01

This study evaluates the effects, on comparative bases, of three different kinds of hydrocarbon products, on physiological and dynamic parameters of a mangrove community (located East of Venezuela), by experimentally monitoring changes on those parameters using Laguncularia racemosa as a bioindicator mangrove species. Orimulsion reg-sign has been introduced recently in the World market; and it is, in essence, an emulsion produced from bitumen mixed with water and stabilized with a surfactant. Results indicate that litter disappearance rate, a parameter directly related to nutrient cycling and dynamics, is not altered by the split Orimulsion reg-sign, when compared to controls; while the other hydrocarbon products tested, seem to exert an impact over this parameter. In addition, Orimulsion reg-sign, is less retained in mangrove sediments compared with the other two products, as indicated by the remaining percent mean of total hydrocarbon soil content sampled on the same consecutive dates. Nonetheless, the photosynthetic capacity of leaves as well as soil respiratory rates, monitored at treatment and control plots, were not affected by any of the products tested. In conclusion, L. racemosa, in terms of its photosynthetic capacity, is not directly affected by any of the hydrocarbon products tested, nor does there seem to be an effect on soil respiration; however, Orimulsion reg-sign, in contrast to the other products, does not seem to be causing an impact with regard to litter dynamics

Study on the Influence of Refreshment/Activation Cycles and Irrigants on Mechanical Cleaning Efficiency During Ultrasonic Activation of the Irrigant

NARCIS (Netherlands)

van der Sluis, Lucas W. M.; Vogels, Maikel P. J. M.; Verhaagen, Bram; Macedo, Ricardo; Wesselink, Paul R.

Introduction: The aims of this study were to evaluate dentin debris removal from the root canal during ultrasonic activation of sodium hypochlorite (2% and 10%), carbonated water, and distilled water and to determine the influence of 3 ultrasonic refreshment/activation cycles of the irrigant by

Study on the influence of refreshment/activation cycles and irrigants on mechanical cleaning efficiency during ultrasonic activation of the irrigant

NARCIS (Netherlands)

van der Sluis, L.W.M.; Vogels, M.P.J.M.; Verhaagen, B.; Macedo, R.; Wesselink, P.R.

2010-01-01

Introduction: The aims of this study were to evaluate dentin debris removal from the root canal during ultrasonic activation of sodium hypochlorite (2% and 10%), carbonated water, and distilled water and to determine the influence of 3 ultrasonic refreshment/activation cycles of the irrigant by

Study on the Influence of Refreshment/Activation Cycles and Irrigants on Mechanical Cleaning Efficiency During Ultrasonic Activation of the Irrigant

NARCIS (Netherlands)

van der Sluis, Lucas W.M.; Vogels, Maikel P.J.M.; Verhaagen, B.; Macedo, Ricardo; Wesselink, Paul R.

2010-01-01

Introduction The aims of this study were to evaluate dentin debris removal from the root canal during ultrasonic activation of sodium hypochlorite (2% and 10%), carbonated water, and distilled water and to determine the influence of 3 ultrasonic refreshment/activation cycles of the irrigant by using

The use of dilute calogen[reg] as a fat density oral contrast medium in upper abdominal computed tomography, compared with the use of water and positive oral contrast media

International Nuclear Information System (INIS)

Ramsay, Duncan W.; Markham, Derrian H.; Morgan, Bruno; Rodgers, Peter M.; Liddicoat, Amanda J.

2001-01-01

AIM: Oral contrast media are commonly given prior to computed tomography (CT) examination of the upper abdomen. Although positive oral contrast media are normally used, there is increasing interest in using negative agents such as water and less commonly fat density products. The aim of this study was to compare a positive oral contrast medium, water, and a diluted emulsion of arachis oil (Calogen[reg], a fat density food supplement) for assessment of the upper abdomen. MATERIALS AND METHODS: Seventy-one patients referred for upper abdominal CT were randomized to receive either 500 ml water, 2% sodium diatrizoate or a dilute suspension of Calogen[reg]. The CT images were scored independently by three radiologists. Distension and anatomical identification was assessed for the stomach, duodenum and jejunum; with anatomical identification recorded for the pancreas, retroperitoneum, liver, gallbladder and spleen. RESULTS: Dilute Calogen[reg] produced a significant improvement (P < 0.01) in distension and anatomical visualization of the stomach and proximal duodenum. Only minimal differences were demonstrated between the three contrast media for visualization of more distal small bowel or identification of the other upper abdominal viscera. Significantly more artifacts were caused by positive contrast media than with the Calogen[reg] mixture. CONCLUSION: A dilute suspension of Calogen[reg] as an oral contrast medium is recommended when disease is suspected within the stomach or proximal duodenum. Ramsay, D.W. et al. (2001)

Factores asociados al cumplimiento del control de crecimiento y desarrollo del niño menor de un año en establecimientos de salud de Amazonas, Loreto y Pasco

Directory of Open Access Journals (Sweden)

Elena Gonzales-Achuy

Full Text Available Objetivos. Identificar los factores asociados al cumplimiento del control de crecimiento y desarrollo (CRED del niño menor de 1 año, en establecimientos de salud del Ministerio de Salud (MINSA de Amazonas, Loreto y Pasco, Perú, de enero a diciembre de 2012. Materiales y métodos. Estudio de casos-controles pareados. Se definió como caso al niño que no completó 11 controles CRED hasta cumplir 11 meses de edad, y como control, aquel niño con 11 controles CRED para la misma edad. La relación entre cada factor con el cumplimiento del CRED se estableció mediante la prueba de McNemar (p<0,05 y como medida de fuerza de asociación el odds ratio (OR para muestras pareadas (IC 95%. Resultados. Siete factores, luego del control de diversas variables, están asociados significativamente al cumplimiento de los controles CRED. El factor común, en las tres regiones, fue que se dejó de atender alguna vez al niño; lo que se asoció, de tres a cinco veces, con la chance de no cumplir los controles CRED en Loreto y Pasco, mientras que en Amazonas se presentó un efecto opuesto (OR 0,58; IC 95% 0,41-0,81. Conclusiones. Existen factores relacionados con el cumplimiento del CRED en niños menores de un año que varían según región. Uno de los principales obstáculos identificados son las múltiples funciones que deben desarrollar los profesionales que laboran en CRED, por lo que se pierden oportunidades de atención al niño; en tal sentido debe garantizarse la dotación suficiente de personal e inculcar permanentemente el buen trato que debe brindarse a los pacientes.

Application of EAP materials toward a refreshable Braille display

Science.gov (United States)

Di Spigna, N.; Chakraborti, P.; Yang, P.; Ghosh, T.; Franzon, P.

2009-03-01

The development of a multiline, refreshable Braille display will assist with the full inclusion and integration of blind people into society. The use of both polyvinylidene fluoride (PVDF) film planar bending mode actuators and silicone dielectric elastomer cylindrical tube actuators have been investigated for their potential use in a Braille cell. A liftoff process that allows for aggressive scaling of miniature bimorph actuators has been developed using standard semiconductor lithography techniques. The PVDF bimorphs have been demonstrated to provide enough displacement to raise a Braille dot using biases less than 1000V and operating at 10Hz. In addition, silicone tube actuators have also been demonstrated to achieve the necessary displacement, though requiring higher voltages. The choice of electrodes and prestrain conditions aimed at maximizing axial strain in tube actuators are discussed. Characterization techniques measuring actuation displacement and blocking forces appropriate for standard Braille cell specifications are presented. Finally, the integration of these materials into novel cell designs and the fabrication of a prototype Braille cell are discussed.

Acceleration (Deceleration Model Supporting Time Delays to Refresh Data

Directory of Open Access Journals (Sweden)

José Gerardo Carrillo González

2018-04-01

Full Text Available This paper proposes a mathematical model to regulate the acceleration (deceleration applied by self-driving vehicles in car-following situations. A virtual environment is designed to test the model in different circumstances: (1 the followers decelerate in time if the leader decelerates, considering a time delay of up to 5 s to refresh data (vehicles position coordinates required by the model, (2 with the intention of optimizing space, the vehicles are grouped in platoons, where 3 s of time delay (to update data is supported if the vehicles have a centre-to-centre spacing of 20 m and a time delay of 1 s is supported at a spacing of 6 m (considering a maximum speed of 20 m/s in both cases, and (3 an algorithm is presented to manage the vehicles’ priority at a traffic intersection, where the model regulates the vehicles’ acceleration (deceleration and a balance in the number of vehicles passing from each side is achieved.

Reappraisal of the diuretic effect of empagliflozin in the EMPA-REG OUTCOME trial: Comparison with classic diuretics.

Science.gov (United States)

Scheen, A J

2016-09-01

Empagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, has been associated with a remarkable reduction in cardiovascular and all-cause mortality in patients with type 2 diabetes and antecedents of cardiovascular disease. This effect was attributed to a diuretic (haemodynamic) rather than metabolic (antiatherogenic) effect. The aim of this review is to offer arguments that either support or challenge this 'diuretic hypothesis'. The literature was scrutinized to: (1) examine the diuretic effects of SGLT2 inhibitors vs. hydrochlorothiazide as the reference diuretic; (2) analyze the effects of classic diuretics on cardiovascular outcomes and mortality in diabetic patients; and (3) reconsider some of the specific analyses of the EMPA-REG OUTCOME trial possibly related to a diuretic effect. The diuretic effect of empagliflozin has so far been poorly investigated, although SGLT2 inhibitors have actions distinct from those of classic diuretics. The effects of thiazide-like diuretics on cardiovascular and overall mortality have been limited in diabetic patients with hypertension, whereas the effects of mineralocorticoid receptor antagonists in subgroups of diabetic patients with heart failure were more impressive, but still largely inferior to those reported in EMPA-REG, where relative reductions in mortality with empagliflozin were observed in diabetic patients with or without heart failure, arterial hypertension, renal impairment or diuretic background therapy. Although the diuretic hypothesis was put forward to explain the remarkable reduction in mortality with empagliflozin in EMPA-REG, the available results do not support a major contribution of this mechanism, unless the specific diuretic effect of SGLT2 inhibitors turns out to be markedly different from those of classic diuretics. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Effects of reducing blood pressure on cardiovascular outcomes and mortality in patients with type 2 diabetes: Focus on SGLT2 inhibitors and EMPA-REG OUTCOME.

Science.gov (United States)

Scheen, André J

2016-11-01

Empagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, has shown a remarkable reduction in cardiovascular and all-cause mortality in patients with type 2 diabetes (T2D) and antecedents of cardiovascular disease in the EMPA-REG OUTCOME trial. This effect has been attributed to a hemodynamic rather than a metabolic effect, partly due to the osmotic/diuretic effect of empagliflozin and to the reduction in arterial blood pressure. The present review will: (1) summarize the results of specific studies having tested the blood pressure lowering effects of SGLT2 inhibitors; (2) describe the results of meta-analyses of trials having evaluated the effects on mortality and cardiovascular outcomes of lowering blood pressure in patients with T2D, with a special focus on baseline and target blood pressures; (3) compare the cardiovascular outcome results in EMPA-REG OUTCOME versus other major trials with antihypertensive agents in patients with T2D; and (4) evaluate post-hoc analyses from EMPA-REG OUTCOME, especially subgroups of patients of special interest regarding the blood pressure lowering hypothesis. Although BP reduction associated to empagliflozin therapy may partly contribute to the benefits reported in EMPA-REG OUTCOME, other mechanisms most probably play a greater role in the overall CV protection and reduction in mortality observed in this trial. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Closing the knowledge gap on cardiovascular disease in type 2 diabetes: the EMPA-REG OUTCOME trial and beyond

Directory of Open Access Journals (Sweden)

Elif A Oral

2016-09-01

Full Text Available Type 2 diabetes mellitus (T2DM is associated with marked cardiovascular (CV morbidity and mortality, including heartfailure (HF. Until recently, an oral glucose-lowering agent that improved hyperglycemia as well as provided CV benefits in patients with T2DM and cardiovascular disease (CVD was lacking. The newest class of glucose-lowering agents, sodium glucose cotransporter 2 (SGLT2 inhibitors, includes canagliflozin, dapagliflozin, and empagliflozin. Prior to the release of the LEADER trial results, the recent EMPA-REG OUTCOME study was the only dedicated CV trial to demonstrate a reduction in major adverse cardiac events, CV mortality, and all-cause mortality and a reduction in hospitalization for HF with empagliflozin, given on top of standard-of-care therapy in patients with T2DM and CVD. This paper summarizes the results from EMPA-REG OUTCOME and discusses their significance and clinical implications.

Influence of refreshment/activation cycles and temperature rise on the reaction rate of sodium hypochlorite with bovine dentine during ultrasonic activated irrigation

NARCIS (Netherlands)

Macedo, R.G.; Verhaagen, B.; Wesselink, P.R.; Versluis, Michel; van der Sluis, L.W.M.

2014-01-01

Aim To evaluate the effect of multiple refreshment/activation cycles and temperature on the reaction rate of sodium hypochlorite (NaOCl) with bovine dentine during ultrasonic activated irrigation (UAI) under laboratory conditions. Methodology The root canal walls of 24 standardized root canals in

OPTIMASI OLSR ROUTING PROTOCOL PADA JARINGAN WIRELESS MESH DENGAN ADAPTIVE REFRESHING TIME INTERVAL DAN ENHANCE MULTI POINT RELAY SELECTING ALGORITHM

Directory of Open Access Journals (Sweden)

Faosan Mapa

2014-01-01

Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Wireless Mesh Network (WMN adalah suatu konektivitas jaringan yang self-organized, self-configured dan multi-hop. Tujuan dari WMN adalah menawarkan pengguna suatu bentuk jaringan nirkabel yang dapat dengan mudah berkomunikasi dengan jaringan konvensional dengan kecepatan tinggi dan dengan cakupan yang lebih luas serta biaya awal yang minimal. Diperlukan suatu desain protokol routing yang efisien untuk WMN yang secara adaptif dapat mendukung mesh routers dan mesh clients. Dalam tulisan ini, diusulkan untuk mengoptimalkan protokol OLSR, yang merupakan protokol routing proaktif. Digunakan heuristik yang meningkatkan protokol OLSR melalui adaptive refreshing time interval dan memperbaiki metode MPR selecting algorithm. Suatu analisa dalam meningkatkan protokol OLSR melalui adaptive refreshing time interval dan memperbaiki algoritma pemilihan MPR menunjukkan kinerja yang signifikan dalam hal throughput jika dibandingkan dengan protokol OLSR yang asli. Akan tetapi, terdapat kenaikan dalam hal delay. Pada simulasi yang dilakukan dapat disimpulkan bahwa OLSR dapat dioptimalkan dengan memodifikasi pemilihan node MPR berdasarkan cost effective dan penyesuaian waktu interval refreshing hello message sesuai dengan keadaan

Innovative remote monitoring of plant health for environmental applications: A joint effort between EPCOT{reg_sign} and the DOE

Energy Technology Data Exchange (ETDEWEB)

Robitaille, H. [Walt Disney World Resort, Lake Buena Vista, FL (United States); Capelle, G.; Di Benedetto, J. [Special Technologies Lab., Santa Barbara, CA (United States)] [and others

1996-12-31

In September of 1994, the US Department of Energy (DOE), Environmental Management, Office of Science and Technology for (OST) and Epcot{reg_sign} in the WALT DISNEY WORLD{reg_sign} Resort (Epcot) signed an agreement to cooperate on the research, development, and public communication and display of environmental technologies. Although Epcot and OST have distinctive missions, certain areas of their respective research and development efforts are common, including the integration of remote sensors with robotics platforms, airborne surveys for environmental characterization and monitoring, and ground based measurements of vegetation stress. The first area of cooperative R&D pursued under the agreement is the evaluation of laser-induced fluorescence imaging (LIFI), a technology developed by OST and proven effective for uranium detection. This paper describes the efforts being conducted under the Epcot-OST agreement and presents initial results. An appendix describing LIFI technology is also included.

Raster Scan Computer Image Generation (CIG) System Based On Refresh Memory

Science.gov (United States)

Dichter, W.; Doris, K.; Conkling, C.

1982-06-01

A full color, Computer Image Generation (CIG) raster visual system has been developed which provides a high level of training sophistication by utilizing advanced semiconductor technology and innovative hardware and firmware techniques. Double buffered refresh memory and efficient algorithms eliminate the problem of conventional raster line ordering by allowing the generated image to be stored in a random fashion. Modular design techniques and simplified architecture provide significant advantages in reduced system cost, standardization of parts, and high reliability. The major system components are a general purpose computer to perform interfacing and data base functions; a geometric processor to define the instantaneous scene image; a display generator to convert the image to a video signal; an illumination control unit which provides final image processing; and a CRT monitor for display of the completed image. Additional optional enhancements include texture generators, increased edge and occultation capability, curved surface shading, and data base extensions.

Comparison of High-Fidelity Simulation Versus Didactic Instruction as a Reinforcement Intervention in a Comprehensive Curriculum for Radiology Trainees in Learning Contrast Reaction Management: Does It Matter How We Refresh?

Science.gov (United States)

Picard, Melissa; Curry, Nancy; Collins, Heather; Soma, LaShonda; Hill, Jeanne

2015-10-01

Simulation-based training has been shown to be a useful adjunct to standard didactic lecture in teaching residents appropriate management of adverse contrast reactions. In addition, it has been suggested that a biannual refresher is needed; however, the type of refresher education has not been assessed. This was a prospective study involving 31 radiology residents across all years in a university program. All residents underwent standard didactic lecture followed by high-fidelity simulation-based training. At approximately 6 months, residents were randomized into a didactic versus simulation group for a refresher. At approximately 9 months, all residents returned to the simulation center for performance testing. Knowledge and confidence assessments were obtained from all participants before and after each phase. Performance testing was obtained at each simulation session and scored based on predefined critical actions. There was significant improvement in knowledge (P didactic and simulation-based training. There was no statistical difference between the simulation and didactic groups in knowledge or confidence at any phase of the study. There was no significant difference in tested performance between the groups in either performance testing session. This study suggests that a curriculum consisting of an annual didactic lecture combined with simulation-based training followed by a didactic refresher at 6 months is an effective and efficient (both cost-effective and time-effective) method of educating radiology residents in the management of adverse contrast reactions. Copyright © 2015 AUR. Published by Elsevier Inc. All rights reserved.

Dissociating rehearsal and refreshing in the maintenance of verbal information in 8-year-old children

Science.gov (United States)

Mora, Gérome; Camos, Valérie

2015-01-01

Recent models of working memory suggest that two systems are involved in verbal working memory: one is dedicated to the maintenance of phonological representations through verbal rehearsal, while the other would maintain multimodal representations through attentional refreshing (Camos et al., 2009; Baddeley, 2012). Previous studies provided evidence on the existence of these two maintenance systems, on their independence, and how they affect recall performance in adults. However, only one study had already explored the relationships between these two systems in children ( Tam et al., 2010). The aim of the present study was to further examine how the two systems account for working memory performance in children. Eight-year-old children performed complex span tasks in which the availability of either the rehearsal or the refreshing was impeded by a concurrent articulation or an attention-demanding task, respectively. Moreover, the phonological similarity of the memoranda was manipulated. Congruently with studies showing that older children can used these maintenance systems, impeding any of the two systems reduced recall performance. Moreover, the manipulation of the two mechanisms did not interact, as previously observed in adults. This suggests that the two maintenance mechanisms are independent in 8-year-old children as they are in adults. However, the results concerning the phonological similarity effect (PSE) differed from what is observed in adults. Whereas the PSE relies only on the availability of rehearsal in adults, a more complex pattern appeared in children: the concurrent articulation as well as the concurrent task modulated the emergence of the PSE. PMID:25667577

Dissociating Rehearsal and Refreshing in the Maintenance of Verbal Information in 8-Year-Old Children

Directory of Open Access Journals (Sweden)

Gérome eMora

2015-01-01

Full Text Available Recent models of working memory suggest that two systems are involved in verbal working memory: one is dedicated to the maintenance of phonological representations through verbal rehearsal, while the other would maintain multimodal representations through attentional refreshing (Baddeley, 2012; Camos et al., 2009. Previous studies provided evidence on the existence of these two maintenance systems, on their independence, and how they affect recall performance in adults. However, only one study had already explored the relationships between these two systems in children (Tam et al., 2010. The aim of the present study was to further examine how the two systems account for working memory performance in children. Eight-year-old children performed complex span tasks in which the availability of either the rehearsal or the refreshing was impeded by a concurrent articulation or an attention-demanding task, respectively. Moreover, the phonological similarity of the memoranda was manipulated. Congruently with studies showing that older children can used these maintenance systems, impeding any of the two systems reduced recall performance. Moreover, the manipulation of the two mechanisms did not interact, as previously observed in adults. This suggests that the two maintenance mechanisms are independent in 8-year-old children as they are in adults. However, the results concerning the phonological similarity effect differed from what is observed in adults. Whereas the phonological similarity effect relies only on the availability of rehearsal in adults, a more complex pattern appeared in children: the concurrent articulation as well as the concurrent task modulated the emergence of the phonological similarity effect.

Dissociating rehearsal and refreshing in the maintenance of verbal information in 8-year-old children.

Science.gov (United States)

Mora, Gérome; Camos, Valérie

2015-01-01

Recent models of working memory suggest that two systems are involved in verbal working memory: one is dedicated to the maintenance of phonological representations through verbal rehearsal, while the other would maintain multimodal representations through attentional refreshing (Camos et al., 2009; Baddeley, 2012). Previous studies provided evidence on the existence of these two maintenance systems, on their independence, and how they affect recall performance in adults. However, only one study had already explored the relationships between these two systems in children ( Tam et al., 2010). The aim of the present study was to further examine how the two systems account for working memory performance in children. Eight-year-old children performed complex span tasks in which the availability of either the rehearsal or the refreshing was impeded by a concurrent articulation or an attention-demanding task, respectively. Moreover, the phonological similarity of the memoranda was manipulated. Congruently with studies showing that older children can used these maintenance systems, impeding any of the two systems reduced recall performance. Moreover, the manipulation of the two mechanisms did not interact, as previously observed in adults. This suggests that the two maintenance mechanisms are independent in 8-year-old children as they are in adults. However, the results concerning the phonological similarity effect (PSE) differed from what is observed in adults. Whereas the PSE relies only on the availability of rehearsal in adults, a more complex pattern appeared in children: the concurrent articulation as well as the concurrent task modulated the emergence of the PSE.

Image registration of BANG[reg] gel dose maps for quantitative dosimetry verification

International Nuclear Information System (INIS)

Meeks, Sanford L.; Bova, Frank J.; Maryanski, Marek J.; Kendrick, Lance A.; Ranade, Manisha K.; Buatti, John M.; Friedman, William A.

1999-01-01

Background: The BANG[reg] (product symbol SGEL, MGS Research Inc., Guilford, CT) polymer gel has been shown to be a valuable dosimeter for determining three-dimensional (3D) dose distributions. Because the proton relaxation rate (R2) of the gel changes as a function of absorbed dose, MR scans of the irradiated gel can be used to generate 3D dose maps. Previous work with the gel, however, has not relied on precise localization of the measured dose distribution. This has limited its quantitative use, as no precise correlation exists with the planned distribution. This paper reports on a technique for providing this correlation, thus providing a quality assurance tool that includes all of the steps of imaging, treatment planning, dose calculation, and treatment localization. Methods and Materials: The BANG[reg] gel formulation was prepared and poured into spherical flasks (15.3-cm inner diameter). A stereotactic head ring was attached to each flask. Three magnetic resonance imaging (MRI) and computed tomography (CT) compatible fiducial markers were placed on the flask, thus defining the central axial plane. A high-resolution CT scan was obtained of each flask. These images were transferred to a radiosurgery treatment-planning program, where treatment plans were developed. The gels were irradiated using our systems for stereotactic radiosurgery or fractionated stereotactic radiotherapy. The gels were MR imaged, and a relative 3D dose map was created from an R2 map of these images. The dose maps were transferred to an image-correlation program, and then fused to the treatment-planning CT scan through a rigid body match of the MRI/CT-compatible fiducial markers. The fused dose maps were imported into the treatment-planning system for quantitative comparison with the calculated treatment plans. Results: Calculated and measured isodose surfaces agreed to within 2 mm at the worst points within the in-plane dose distributions. This agreement is excellent, considering that

Road map towards a common harmonised Nordic end-user market. NordREG report 5 - 2013

Energy Technology Data Exchange (ETDEWEB)

NONE

2013-07-01

The purpose of this road map is to describe the overall process to harmonise the Nordic electricity end-user markets. The main target groups for the road map are the Nordic governments, legislators and the electricity industry. The road map will continuously be updated as the project progresses, at least once a year. It describes the recommendations already made by NordREG, as well as indicates up-coming recommendations. One important part of the Nordic harmonisation process is the monitoring of the progress of the project. It will be communicated through national implementation monitoring overviews, which will describe the state of play for each recommendation made by NordREG. The road map highlights the importance of national commitment by different stakeholders, authorities and governments in order to successfully harmonise the Nordic end-user markets. This commitment is absolutely essential. The goal for 2015 is to harmonise some of the legislation, rules and processes that constitute barriers for suppliers to establish their business in other Nordic countries. In order to achieve this goal, NordREG is working towards defining responsibilities in the customer interface of the supplier centric model and the way of billing the customers. Another important task is related to development of an efficient way of communication among a large number of Nordic electricity companies. By 2015 the end-user markets should be harmonised to the extent that the most critical prerequisites have been achieved. But it is important to bear in mind that there are still many more steps to be taken also after 2015. The harmonisation process between the Nordic retail markets is a process that will continue for the foreseeable future. Since there is no supranational organisation or institution (like in the EU), it means that any future development of the Nordic retail market will have to be continuously coordinated between the Nordic countries to ensure that the markets maintain the

A prospective randomised controlled trial to determine the early and late reactions after the use of iopamidol 340 (NiopamTM) and iomeprol 350 (Iomeron[reg]) in cardiac catheterisation

International Nuclear Information System (INIS)

Vijayalakshmi, Kunadian; Kunadian, Babu; Wright, Robert A.; Hall, James A.; Stewart, Michael J.; Davies, Adrian; Sutton, Andrew; Belder, Mark A. de

2007-01-01

A new generation of intravascular contrast agents, the non-ionic monomers have safety profiles that are superior to those of older ionic compounds. There are, however, significant differences between these agents. Aim: The aim of this study was to determine the incidence of early ( 24 h to 7 days) reactions to two non-ionic contrast agents currently used during cardiac catheterisation: iopamidol 340 (Niopam TM Bracco UK Ltd.) and iomeprol 350 (Iomeron[reg] Bracco UK Ltd.). Methods: This was a prospective, randomised, double blinded trial. One thousand nine hundred and eighty-five patients undergoing cardiac catheterisation received one of the following contrast agents on a weekly basis: iopamidol 340 (Niopam TM ) and iomeprol 350 (Iomeron[reg]). Reactions that were possibly related to the contrast agents were recorded on predefined data collection forms during the first 24 h of the procedure (early reaction) and after 24 h to 7 days (late reaction) by means of a questionnaire. Results: The baseline characteristics were matched in both the groups. There was no significant difference in the incidence of heat sensation experienced between the two groups (p = 0.1). Early non-heat reactions occurred in 2.7% of patients receiving iopamidol 340 (Niopam TM ) and 4% of those receiving iomeprol 350 (Iomeron[reg]) (p = 0.1). Significant electrocardiographic changes were recorded in 1.7% of patients who received iopamidol 340 (Niopam TM ), and 1% of those who received iomeprol 350 (Iomeron[reg]) (p = 0.2). Bradycardia occurred more frequently in the iopamidol 350 group (0.8%) compared to the iomeprol 350 group (0.1%) p = 0.02. Late reactions occurred in 16.2% of those receiving iopamidol 340 (Niopam TM ) and 21.7% of those receiving iomeprol 350 (Iomeron[reg] (p = 0.02). A total of 23 (3.7%) patients in the iopamidol group and 39 (6.2%) patients in the iomeprol group reported nausea, p = 0.01. Conclusions: The incidence of early adverse reactions was similar with the two non

Simulation of Optical Properties and Direct and Indirect Radiative Effects of Smoke Aerosols Over Marine Stratocumulus Clouds During Summer 2008 in California With the Regional Climate Model RegCM

Science.gov (United States)

Mallet, M.; Solmon, F.; Roblou, L.; Peers, F.; Turquety, S.; Waquet, F.; Jethva, H.; Torres, O.

2017-10-01

The regional climate model RegCM has been modified to better account for the climatic effects of biomass-burning particles. Smoke aerosols are represented by new tracers with consistent radiative and hygroscopic properties to simulate the direct radiative forcing (DRF), and a new parameterization has been integrated for relating the droplet number concentration to the aerosol concentration for marine stratocumulus clouds (Sc). RegCM has been tested during the summer of 2008 over California, when extreme concentration of smoke, together with the presence of Sc, is observed. This work indicates that significant aerosol optical depth (AOD) ( 1-2 at 550 nm) is related to the intense 2008 fires. Compared to Ozone Monitoring Instrument (OMI) and Moderate Resolution Imaging Spectroradiometer, the regional pattern of RegCM AOD is well represented although the magnitude is lower than satellite observations. Comparisons with Polarization and Directionality of Earth Reflectances (POLDER) above-clouds aerosol optical depth (ACAOD) show the ability of RegCM to simulate realistic ACAOD during the transport of smoke above the Pacific Ocean. The simulated single scattering albedo is 0.90 (at 550 nm) near biomass-burning sources, consistent with OMI and POLDER, and smoke leads to shortwave heating rates 1.5-2°K d-1. RegCM is not able to correctly resolve the daily patterns in cloud properties notably due to its coarse horizontal resolutions. However, the changes in the sign of the DRF at top of atmosphere (TOA) (negative to positive) from clear-sky to all-sky conditions is well simulated. Finally, the "aerosol-cloud" parameterization allows simulating an increase of the cloud optical depth for significant concentrations, leading to large perturbations of radiative fluxes at TOA.

Hydrology of the coastal springs ground-water basin and adjacent parts of Pasco, Hernando, and Citrus Counties, Florida

Science.gov (United States)

Knochenmus, Lari A.; Yobbi, Dann K.

2001-01-01

The coastal springs in Pasco, Hernando, and Citrus Counties, Florida consist of three first-order magnitude springs and numerous smaller springs, which are points of substantial ground-water discharge from the Upper Floridan aquifer. Spring flow is proportional to the water-level altitude in the aquifer and is affected primarily by the magnitude and timing of rainfall. Ground-water levels in 206 Upper Floridan aquifer wells, and surface-water stage, flow, and specific conductance of water from springs at 10 gaging stations were measured to define the hydrologic variability (temporally and spatially) in the Coastal Springs Ground-Water Basin and adjacent parts of Pasco, Hernando, and Citrus Counties. Rainfall at 46 stations and ground-water withdrawals for three counties, were used to calculate water budgets, to evaluate long-term changes in hydrologic conditions, and to evaluate relations among the hydrologic components. Predictive equations to estimate daily spring flow were developed for eight gaging stations using regression techniques. Regression techniques included ordinary least squares and multiple linear regression techniques. The predictive equations indicate that ground-water levels in the Upper Floridan aquifer are directly related to spring flow. At tidally affected gaging stations, spring flow is inversely related to spring-pool altitude. The springs have similar seasonal flow patterns throughout the area. Water-budget analysis provided insight into the relative importance of the hydrologic components expected to influence spring flow. Four water budgets were constructed for small ground-water basins that form the Coastal Springs Ground-Water Basin. Rainfall averaged 55 inches per year and was the only source of inflow to the Basin. The pathways for outflow were evapotranspiration (34 inches per year), runoff by spring flow (8 inches per year), ground-water outflow from upward leakage (11 inches per year), and ground-water withdrawal (2 inches per year

Modelo climático de los páramos de la Cordillera Oriental colombiana aplicado a regímenes de temperatura del suelo

Directory of Open Access Journals (Sweden)

Carlos Enrique Castro Méndez

2016-06-01

Full Text Available La aplicación (con criterios consistentes de los regímenes de temperatura del suelo, no había sido necesaria y decisiva, hasta ahora, ya que se consideraba suficiente esta información de carácter descriptivo. La temperatura asignada al suelo provenía de la reclasificación directa del clima ambiental al edáfico con valores medios anuales dados a cada franja altitudinal hace más de 200 años, esto no es acorde con los cambios, que desde la geografía biofísica, se han percibido en el ambiente. Se propone un modelo climático, basado en isotermas del suelo, para determinar los regímenes de temperatura a partir de información bajo coberturas vegetales y del suelo, para cada vertiente montañosa en particular. Se encontraron gradientes de temperatura (ºC/100 m de 0,73 y 0,61 en la vertiente occidental y oriental, respectivamente. La temperatura del suelo fue 1.9 ºC mayor que la del aire y se delimitaron los regímenes térmicos del suelo cryico, isofrígido e isomésico.

Influence of glyphosate and its formulation (Roundup[reg]) on the toxicity and bioavailability of metals to Ceriodaphnia dubia

Energy Technology Data Exchange (ETDEWEB)

Tsui, Martin T.K. [Department of Biology, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong (China); Department of Biology, Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong (China); Wang Wenxiong [Department of Biology, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong (China); Chu, L.M. [Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong (China)]. E-mail: leemanchu@cuhk.edu.hk

2005-11-15

This study examined the toxicological interaction between glyphosate (or its formulation, Roundup[reg]) and several heavy metals to a freshwater cladoceran, Ceriodaphnia dubia. We demonstrated that all binary combinations of Roundup[reg] and metals (Cd, Cu, Cr, Ni, Pb, Se and Zn) exhibited 'less than additive' mixture toxicity, with 48-h LC50 toxic unit>1. Addition of glyphosate alone could significantly reduce the acute toxicity of Ag, Cd, Cr, Cu, Ni, Pb and Zn (but not Hg and Se). The ratio between glyphosate and metal ions was important in determining the mitigation of metal toxicity by glyphosate. A bioaccumulation study showed that in the presence of glyphosate the uptake of some metals (e.g. Ag) was halted but that of others (e.g. Hg) was increased significantly. Therefore, our study strongly suggests that glyphosate and its commercial formulations can control the toxicity as well as the bioavailability of heavy metals in aquatic ecosystems where both groups of chemicals can co-occur. - Glyphosate can control the toxicity and bioavailability of many heavy metals in the aquatic environment.

Influence of glyphosate and its formulation (Roundup[reg]) on the toxicity and bioavailability of metals to Ceriodaphnia dubia

International Nuclear Information System (INIS)

Tsui, Martin T.K.; Wang Wenxiong; Chu, L.M.

2005-01-01

This study examined the toxicological interaction between glyphosate (or its formulation, Roundup[reg]) and several heavy metals to a freshwater cladoceran, Ceriodaphnia dubia. We demonstrated that all binary combinations of Roundup[reg] and metals (Cd, Cu, Cr, Ni, Pb, Se and Zn) exhibited 'less than additive' mixture toxicity, with 48-h LC50 toxic unit>1. Addition of glyphosate alone could significantly reduce the acute toxicity of Ag, Cd, Cr, Cu, Ni, Pb and Zn (but not Hg and Se). The ratio between glyphosate and metal ions was important in determining the mitigation of metal toxicity by glyphosate. A bioaccumulation study showed that in the presence of glyphosate the uptake of some metals (e.g. Ag) was halted but that of others (e.g. Hg) was increased significantly. Therefore, our study strongly suggests that glyphosate and its commercial formulations can control the toxicity as well as the bioavailability of heavy metals in aquatic ecosystems where both groups of chemicals can co-occur. - Glyphosate can control the toxicity and bioavailability of many heavy metals in the aquatic environment

Dicionário multilíngue de regência verbal: equivalentes em francês

OpenAIRE

Sao, Mayara Stringhetta [UNESP

2009-01-01

Este trabalho vincula-se a uma pesquisa maior que está sendo desenvolvida simultaneamente por pesquisadores do GP “Lexicologia e Lexicografia contrastiva”. Tratamos da elaboração de uma obra de referência multilíngüe especial e inédita: o Dicionário Multilíngüe de Regência Verbal: verbos preposicionados, na direção português-alemão / espanhol / francês / inglês / italiano / japonês. Com base no levantamento já realizado dos verbos transitivos indiretos ou transitivos diretos e indiretos mais ...

The establishment and utility of Sweha-Reg: a Swedish population-based registry to understand hereditary angioedema

Directory of Open Access Journals (Sweden)

Werner Sonja

2007-11-01

Full Text Available Abstract Background The importance of acquiring comprehensive epidemiological and clinical data on hereditary angioedema has increasingly caught the attention of physicians and scientists around the world. The development of networks and creation of comprehensive policies to improve care of people suffering from rare diseases, such as hereditary angioedema, is a stated top priority of the European Union. Hereditary angioedema is a rare disease, that it may be life-threatening. Although the exact prevalence is unknown, current estimates suggest that it is 1/10,000–1/150,000 individuals. The low prevalence requires combined efforts to gain accurate epidemiological data on the disease and so give us tools to reduce morbidity and mortality, and improve quality of life of sufferers. Methods Sweha-Reg is a population-based registry of hereditary angioedema in Sweden with the objectives of providing epidemiological data, and so creates a framework for the study of this disease. The registry contains individual-based data on diagnoses, treatments and outcomes. Conclusion The present manuscript seeks to raise awareness of the existence of Sweha-Reg to stimulate the international collaboration of registries. A synthesis of data from similar registries across several countries is required to approach an inclusive course understanding of HAE.

Spatial performance of RegEM climate field reconstruction techniques in a realistic pseudoproxy context

Science.gov (United States)

Wang, J.; Emile-Geay, J.; Guillot, D.

2011-12-01

Several methods of climate field reconstructions (CFRs) have been introduced in the past few years to estimate past climate variability from proxy data over the Common Era. The pseudoproxy framework has become a tool of choice for assessing the relative merits of such methods. Here we compare four variants of the RegEM algorithm [Schneider, 2001], using a pseudoproxy network mimicking the key spatio-temporal characteristics of the network of Mann et al., 2008 (hereinafter M08); the methods are (1) RegEM TTLS (2) RegEM iTTLS (3) GraphEM and (4) RegEM iRIDGE. To ensure continuity with previous work [Smerdon et al. 2011], pseudoproxy series are designed as a white-noise degraded version of the simulated temperature field [Amman et al. 2007] over 850-1980 C.E. colocated with 1138 M08 proxies. We use signal-to-noise ratios (SNRs) of: ∞ (no noise), 1.0, 0.5 and 0.25, to simulate differences in proxy quality. Two novelties in pseudoproxy design are introduced here: (1) the decrease in proxy availability over time follows that found in M08, (2) a realistic case where the SNR is empirically derived from correlations between each M08 proxy and the HadCRUT3v temperature field. It is found that this realistic SNR is clustered around 0.3, but ranges from 0.1 to 0.8. Verification statistics such as RE, CE, r2, bias, standard deviation ratio and RMSE are presented for each method at each SNR level. The results show that all methods perform relatively well at SNR levels higher than 0.5, but display drastically different performances at lower SNR levels. Compared with results using pseudoproxy network of Mann et al., 1998, (hereinafter MBH98), the reconstruction skill of the M08 network is relatively improved, in line with the findings of Smerdon et al., 2011. Overall, we find that GraphEM and iTTLS tend to produce more robust estimates of the temperature field at low SNR levels than other schemes, while preserving a higher amount of variance in the target field. Ammann, C. M., F

Serum levels of pancreatic stone protein (PSP/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY carriers from the third decade of life onward

Directory of Open Access Journals (Sweden)

Bacon Siobhan

2012-07-01

Full Text Available Abstract Background Mutations in the transcription factor hepatocyte nuclear factor-1-alpha (HNF1A result in the commonest type of maturity onset diabetes of the young (MODY. HNF1A-MODY carriers have reduced pancreatic beta cell mass, partially due to an increased rate of apoptosis. To date, it has not been possible to determine when apoptosis is occurring in HNF1A-MODY.We have recently demonstrated that beta cell apoptosis stimulates the expression of the pancreatic stone protein/regenerating (PSP/reg gene in surviving neighbour cells, and that PSP/reg1A protein is subsequently secreted from these cells. The objective of this study was to determine whether serum levels of PSP/reg1A are elevated during disease progression in HNF1A-MODY carriers, and whether it may provide information regarding the onset of beta-cell apoptosis. Methods We analysed serum PSP/reg1A levels and correlated with clinical and biochemical parameters in subjects with HNF1A-MODY, glucokinase (GCK-MODY, and type 1 diabetes mellitus. A control group of normoglycaemic subjects was also analysed. Results PSP/reg1A serum levels were significantly elevated in HNF1A-MODY (n = 37 subjects compared to controls (n = 60 (median = 12.50 ng/ml, IQR = 10.61-17.87 ng/ml versus median = 10.72 ng/ml, IQR = 8.94-12.54 ng/ml, p = 0.0008. PSP/reg1A correlated negatively with insulin levels during OGTT, (rho = −0.40, p = 0.02. Interestingly we noted a significant positive correlation of PSP/reg1A with age of the HNF1A-MODY carriers (rho = 0.40 p = 0.02 with an age of 25 years separating carriers with low and high PSP/reg1A levels. Patients with type 1 diabetes mellitus also had elevated serum levels of PSP/reg1A compared to controls, however this was independent of the duration of diabetes. Conclusion Our data suggest that beta cell apoptosis contributes increasingly to the pathophysiology of HNF1A-MODY in patients 25 years and over

Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward

LENUS (Irish Health Repository)

Bacon, Siobhan

2012-07-18

AbstractBackgroundMutations in the transcription factor hepatocyte nuclear factor-1-alpha (HNF1A) result in the commonest type of maturity onset diabetes of the young (MODY). HNF1A-MODY carriers have reduced pancreatic beta cell mass, partially due to an increased rate of apoptosis. To date, it has not been possible to determine when apoptosis is occurring in HNF1A-MODY.We have recently demonstrated that beta cell apoptosis stimulates the expression of the pancreatic stone protein\\/regenerating (PSP\\/reg) gene in surviving neighbour cells, and that PSP\\/reg1A protein is subsequently secreted from these cells. The objective of this study was to determine whether serum levels of PSP\\/reg1A are elevated during disease progression in HNF1A-MODY carriers, and whether it may provide information regarding the onset of beta-cell apoptosis.MethodsWe analysed serum PSP\\/reg1A levels and correlated with clinical and biochemical parameters in subjects with HNF1A-MODY, glucokinase (GCK-MODY), and type 1 diabetes mellitus. A control group of normoglycaemic subjects was also analysed.ResultsPSP\\/reg1A serum levels were significantly elevated in HNF1A-MODY (n = 37) subjects compared to controls (n = 60) (median = 12.50 ng\\/ml, IQR = 10.61-17.87 ng\\/ml versus median = 10.72 ng\\/ml, IQR = 8.94-12.54 ng\\/ml, p = 0.0008). PSP\\/reg1A correlated negatively with insulin levels during OGTT, (rho = −0.40, p = 0.02). Interestingly we noted a significant positive correlation of PSP\\/reg1A with age of the HNF1A-MODY carriers (rho = 0.40 p = 0.02) with an age of 25 years separating carriers with low and high PSP\\/reg1A levels. Patients with type 1 diabetes mellitus also had elevated serum levels of PSP\\/reg1A compared to controls, however this was independent of the duration of diabetes.ConclusionOur data suggest that beta cell apoptosis contributes increasingly to the pathophysiology of HNF1A-MODY in patients 25 years and

The effect of peer-group size on the delivery of feedback in basic life support refresher training: a cluster randomized controlled trial.

Science.gov (United States)

Cho, Youngsuk; Je, Sangmo; Yoon, Yoo Sang; Roh, Hye Rin; Chang, Chulho; Kang, Hyunggoo; Lim, Taeho

2016-07-04

Students are largely providing feedback to one another when instructor facilitates peer feedback rather than teaching in group training. The number of students in a group affect the learning of students in the group training. We aimed to investigate whether a larger group size increases students' test scores on a post-training test with peer feedback facilitated by instructor after video-guided basic life support (BLS) refresher training. Students' one-rescuer adult BLS skills were assessed by a 2-min checklist-based test 1 year after the initial training. A cluster randomized controlled trial was conducted to evaluate the effect of student number in a group on BLS refresher training. Participants included 115 final-year medical students undergoing their emergency medicine clerkship. The median number of students was 8 in the large groups and 4 in the standard group. The primary outcome was to examine group differences in post-training test scores after video-guided BLS training. Secondary outcomes included the feedback time, number of feedback topics, and results of end-of-training evaluation questionnaires. Scores on the post-training test increased over three consecutive tests with instructor-led peer feedback, but not differ between large and standard groups. The feedback time was longer and number of feedback topics generated by students were higher in standard groups compared to large groups on the first and second tests. The end-of-training questionnaire revealed that the students in large groups preferred the smaller group size compared to their actual group size. In this BLS refresher training, the instructor-led group feedback increased the test score after tutorial video-guided BLS learning, irrespective of the group size. A smaller group size allowed more participations in peer feedback.

Chemical and radiation stability of SuperLig reg-sign 644, resorcinol-formaldehyde, and CS-100 cesium ion exchange materials

International Nuclear Information System (INIS)

Brown, G.N.; Adami, S.R.; Bray, L.A.

1995-09-01

At the request of the Initial Pretreatment Module Project within Westinghouse Hanford Company, Pacific Northwest Laboratory (PNL) conducted this study for the Efficient Separations and Processing Crosscutting Program (ESP) under the task ''Develop and Test Sorbents.'' The purpose of the study was to assess and compare the chemical and radiolytic stability of several cesium-selective ion exchange materials in simulated alkaline Hanford tank waste matrices. Pretreatment of nuclear process wastes to remove of cesium and other radionuclides by ion exchange was proposed previously as one method of minimizing the amount of high-level radioactive waste at Hanford. In this study, PNL evaluated three cesium-selective materials SuperLig reg-sign 644, resorcinol-formaldehyde (R-F), and CS-100 for chemical and radiation stability in 1 M NaOH and a simulated neutralized current acid waste (NCAW). The objective of the study is to investigate the stability of the newly produced SuperLig reg-sign 644 under a variety of conditions in an attempt to simulate and predict the degradation process. The following specific conclusions and recommendations resulted from the study

Chemical and radiation stability of SuperLig{reg_sign}644, resorcinol-formaldehyde, and CS-100 cesium ion exchange materials

Energy Technology Data Exchange (ETDEWEB)

Brown, G.N.; Adami, S.R.; Bray, L.A. [and others

1995-09-01

At the request of the Initial Pretreatment Module Project within Westinghouse Hanford Company, Pacific Northwest Laboratory (PNL) conducted this study for the Efficient Separations and Processing Crosscutting Program (ESP) under the task ``Develop and Test Sorbents.`` The purpose of the study was to assess and compare the chemical and radiolytic stability of several cesium-selective ion exchange materials in simulated alkaline Hanford tank waste matrices. Pretreatment of nuclear process wastes to remove of cesium and other radionuclides by ion exchange was proposed previously as one method of minimizing the amount of high-level radioactive waste at Hanford. In this study, PNL evaluated three cesium-selective materials SuperLig{reg_sign}644, resorcinol-formaldehyde (R-F), and CS-100 for chemical and radiation stability in 1 M NaOH and a simulated neutralized current acid waste (NCAW). The objective of the study is to investigate the stability of the newly produced SuperLig{reg_sign}644 under a variety of conditions in an attempt to simulate and predict the degradation process. The following specific conclusions and recommendations resulted from the study.

Vascular legacy: HOPE ADVANCEs to EMPA-REG and LEADER: A Surprising similarity

Directory of Open Access Journals (Sweden)

Sanjay Kalra

2017-01-01

Full Text Available Recently reported cardiovascular outcome studies on empagliflozin (EMPA-REG and liraglutide (LEADER have spurred interest in this field of diabetology. This commentary compares and contrasts these studies with two equally important outcome trials conducted using blood pressure lowering agents. A comparison with MICROHOPE (using ramipril and ADVANCE (using perindopril + indapamide blood pressure arms throws up interesting facts. The degree of blood pressure lowering, dissociation between cardiovascular and cerebrovascular benefits, and discordance between renal and retinal outcomes are surprisingly similar in these trials, conducted using disparate molecules. The time taken to achieve such benefits is similar for all drugs except empagliflozin. Such discussion helps inform rational and evidence-based choice of therapy and forms the framework for future research.

Precipitação sazonal sobre a Amazônia oriental no período chuvoso: observações e simulações regionais com o RegCM3 Seasonal precipitation in eastern Amazon during rainy season: regional observations and RegCM3 simulations

Directory of Open Access Journals (Sweden)

Everaldo B. de Souza

2009-06-01

Full Text Available O presente trabalho apresenta uma contribuição aos estudos de modelagem climática com ênfase na variabilidade pluviométrica sazonal da Amazônia oriental, durante as estações de verão e outono (DJF e MAM. Baseado nos resultados das simulações regionais do RegCM3 para um período de 26 anos (1982/83 a 2007/08 e usando domínio em alta resolução espacial (30 Km e dois diferentes esquemas de convecção (Grell e MIT, foi investigado o desempenho do modelo em simular a distribuição regional de precipitação sazonal na Amazônia oriental, com referência a um novo conjunto de dados observacional compilado com informações de uma ampla rede integrada de estações pluviométricas. As análises quantitativas evidenciaram que o RegCM3 apresenta erros sistemáticos, sobretudo aqueles relacionados com viés seco no Amapá e norte/nordeste do Pará usando ambos os esquemas Grell e MIT, os quais apontam que o modelo não reproduz as características da ZCIT sobre o Atlântico equatorial. As simulações usando MIT, também apresentaram viés úmido no sudoeste/sul/sudeste do Pará e norte do Tocantins. Além disso, através da técnica de composições, também foi investigado o desempenho do RegCM3 em reproduzir os padrões espaciais anômalos de precipitação sazonal em associação aos episódios ENOS, e as fases do gradiente térmico sobre o Atlântico intertropical. Os resultados demonstraram que o modelo conseguiu representar realisticamente bem o padrão espacial das anomalias pluviométricas acima (abaixo do normal em grande parte da Amazônia oriental, durante os conhecidos cenários favoráveis, i.e., condições de La Niña e gradiente de aTSM para o Atlântico sul (desfavoráveis, i.e., El Niño e gradiente de aTSM para o Atlântico norte.This paper presents a contribution on the climate modelling studies with emphasis on seasonal rainfall variability in eastern Amazonia, during the austral summer and autumn seasons (DJF and MAM

Impact assessment of WHO TobReg proposals for mandated lowering of selected mainstream cigarette smoke toxicants.

Science.gov (United States)

Eldridge, Alison C; McAdam, Kevin G; Betson, Tatiana R; Gama, Marcos V; Proctor, Christopher J

2017-06-01

The WHO Tobacco Product Regulation Study Group (TobReg) has proposed three regulatory models for cigarettes, each creating mandatory limits for emissions of nine smoke toxicants. One approach proposes country-specific limits, using median or 1.25× median toxicant/nicotine emission ratios. A second model provides fixed toxicant-ratio limits. The third model limits were three times the lowest toxicant emission on a market. Currently, the practical implications of these models are largely unknown. An impact assessment was conducted using cigarette data from 79 countries to identify four diverse test markets. We sampled all products from each market but limited product availability led to incomplete (80-97%) sourcing. Analysis showed that the country-specific model led to diverse (up to threefold) toxicant limits across the four markets. 70%-80% of products were non-compliant, rising to 100% in some countries with the second and the third models. With each regulatory model the main drivers of non-compliance were the tobacco-specific nitrosamines, the simultaneous application of limits for nine poorly correlated smoke toxicants, and analytical variability. Use of nicotine ratios led to compliance of some high toxicant emission products due to high nicotine emissions. Our findings suggest that these proposals would have greater impact on global markets than TobReg's stated aims. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Demonstration of criticality safety for the modified TN-REG and TN-BRP transport/storage casks

International Nuclear Information System (INIS)

Parks, C.V.; Fox, P.B.

1989-01-01

An inability to model the structural performance of borated steel baskets under accident conditions forced the specially designed TN-BRP and TN-REG casks to be modified for half-loaded shipments. This paper discusses the approach used to demonstrate that the half-loaded casks would remain safely subcritical even if no credit were taken for the borated basket. Normal and accident configurations were analyzed with the KENO V.a code. The strategy conceived and the analyses performed to demonstrate an acceptable margin of safety are discussed. 5 refs., 3 figs., 2 tabs

Simulation of Relationship between ENSO and winter precipitation over Western Himalayas: Application of Regional climate model (RegT-Band)

Science.gov (United States)

Tiwari, P. R.; Mohanty, U. C.; Dey, S.; Acharaya, N.; Sinha, P.

2012-12-01

Precipitation over the Western Himalayas region during winter is mainly associated with the passage of midlatitude synoptic systems known as western disturbances (WDs). Recently, many observational and modeling studies reported that the relationship of the Indian southwest monsoon rainfall with El Niño- Southern Oscillation (ENSO) has weakened since around 1980. But, in contrast, only very few observational studies are reported so far to examine the relationship between ENSO and the winter precipitation over the Western Himalayas region from December to February (DJF). But there is a huge gap of modeling this phenomenon. So keeping in view of the absence of modeling studies, an attempt is made to simulate the relationship between wintertime precipitations associated with large scale global forcing of ENSO over the Western Himalayas. In the present study, RegT-Band, a tropical band version of the regional climate model RegCM4 is integrated for a set of 5 El Niño (1986-87, 1991-92, 1997-98, 2002-03, 2009-10) and 4 La Niña (1984-85, 1988-89, 1999-2000, 2007-08) years with the observed sea-surface temperature and lateral boundary condition. The domain extends from 50° S to 50° N and covers the entire tropics at a grid spacing of about 45 km, i.e. it includes lateral boundary forcing only at the southern and northern boundaries. The performance evaluation of the model in capturing the large scale fields followed by ENSO response with wintertime precipitation over the Western Himalayas region has been carried out by using National Center for Environmental Prediction (NCEP)-Department of Energy (DOE) reanalysis 2 (NNRP2) data (2.5° x 2.5°) and Aphrodite precipitation data (0.25° x 0.25°). The model is able to delineate the mean circulation associated with ENSO over the region during DJF reasonably well and shows strong southwesterly to northwesterly wind flow, which is there in verification analysis also. The vertical structure of the low as well as upper level

Assessing the effectiveness of RegCM4 regional climate model in simulating the aerosol optical depth patterns over the region of Eastern Mediterranean

Science.gov (United States)

Georgoulias, Aristeidis K.; Tsikerdekis, Athanasios; Ntogras, Christos; Zanis, Prodromos

2014-05-01

In this work, the ability of the regional climate model RegCM4 to simulate the aerosol optical depth (AOD) patterns over the region of Eastern Mediterranean is assessed. Three separate runs were implemented within the framework of the QUADIEEMS project for the time period 2000-2010 at a horizontal resolution of 50km covering the region of Europe. ERA-interim data were used as lateral boundary conditions while the model was driven by emissions from CMIP5. In the first case, the total of the aerosol types that RegCM4 accounts for were included (sulfate, black carbon, sea salt, dust), while in the other two cases only anthropogenic and dust particles were taken into account, respectively. The total AOD patterns were compared against level-2 satellite observations from MODIS TERRA and AQUA and ground-based measurements from 12 AERONET sites located in the region. In addition, the RegCM4 anthropogenic and dust AOD patterns were compared against the anthropogenic and dust component of MODIS AOD which was calculated using a combination of various satellite, model and reanalysis products. Our results indicate a significant underestimation of the anthropogenic AOD, while, on the contrary, the dust AOD fields are simulated in a more efficient way. The QUADIEEMS project is co-financed by the European Social Fund (ESF) and national resources under the operational programme Education and Lifelong Learning (EdLL) within the framework of the Action "Supporting Postdoctoral Researchers".

ROTO PEEN Scalar and VAC-PAC reg-sign system

International Nuclear Information System (INIS)

1998-02-01

The Pentek, Inc., milling technology, comprising the ROTO PEEN Scaler and the VAC-PAC reg-sign waste collection system, is a fully developed and commercialized technology used to remove hazardous coatings from concrete and steel floors, walls, ceilings, and structural components. This report describes a demonstration of the Pentek, Inc., milling system to remove the paint coating from 650 ft 2 of concrete flooring on the service floor of the Chicago Pile-5 (CP-5) Research Reactor. CP-5 is a heavy-water moderated and cooled, highly enriched, uranium-fueled thermal reactor designed to supply neutrons for research. The reactor had a thermal-power rating of 5 megawatts and was operated continuously for 25 years until its final shutdown in 1979. These 25 years of operation produced activation and contamination characteristics representative of other nuclear facilities within the Department of Energy (DOE) complex and the commercial nuclear sector. CP-5 contains many of the essential features of other DOE and commercial nuclear facilities and can be used safely as a demonstration facility for the evaluation of innovative technologies for the future D and D of much larger, more highly contaminated facilities

Bio-normalyzer[reg]: An anti-cancer drug for neuroblastoma?

International Nuclear Information System (INIS)

Gouget, B.; Sergeant, C.; Llabador, Y.; Simonoff, M.

2001-01-01

Iron is an essential micronutrient required for cell division and growth. Incorporation of iron into cells is achieved by endocytosis of transferrin. Then, iron may be stored in ferritin and hemosiderin. Increased intracellular iron concentrations may promote malignant cell growth. Patients with advanced-stage neuroblastoma (NB) show abnormally high levels of serum ferritin, very likely synthesized and secreted by the tumor in vivo and consistent with a frequent accumulation of iron in ferritin in NB tumor tissues. In a previous study, we showed that there is no iron accumulation in cultured neuroblasts, and intracellular iron concentrations proved to be especially low. Bio-Normalizer[reg] (BioN) is a nutritional supplement sold to be an anti-oxidant and metal-chelator. In the present study, we tested cell viability and measured iron concentrations in neuroblasts treated or not with BioN. We found that BioN, probably thanks to papain, presents an anti-proliferative effect on NB cultured cells. Besides, preliminary results tend to prove that this natural anti-oxidant and iron-chelator could present interesting effects on trace metal concentrations in neuroblasts. Such a compound may be useful in treatment of this pathology

La política de la protesta en regímenes autoritarios: síntesis crítica

Directory of Open Access Journals (Sweden)

Felipe Sánchez Barría

Full Text Available RESUMEN Introducción A través de una revisión crítica de la literatura reciente, el ensayo explora la relación entre protesta contenciosa y regímenes autoritarios, y examina las dinámicas y consecuencias que emergen durante el conflicto político. Métodos Para lo anterior se discuten tres elementos que los especialistas han identificado como los principales en esta relación: oportunidades y amenazas políticas; ciclos de protesta y sostenibilidad de los movimientos sociales; y la relación entre violencia estatal y acción colectiva. Resultados La recurrencia de la protesta en regímenes represivos muestra la capacidad de la sociedad civil para articular este tipo de acciones contenciosas. Discusión No obstante, las trayectorias y resultados dependen, por una parte, de las características políticas del régimen y la competencia del gobierno para responder a los desafíos colectivos; y, por otra parte, de la capacidad de los oponentes de montar ciclos de protestas densos en participación durante un periodo significativo, del tipo de tácticas adoptadas, y de la capacidad de adaptación y resiliencia a la violencia estatal.

Application of NUHOMS reg-sign to an integrated MRS/transportation system

International Nuclear Information System (INIS)

Rosa, J.M.; Lehnert, R.A.; Quinn, R.D.

1992-01-01

Storage of spent fuel at reactor sites in weld sealed canisters has been increasing steadily since 1989, with three facilities now having ISFSIs which employ the NUHOMS reg-sign technology. Expansion of existing Independent Spent Fuel Storage Installations (ISFSIs) and implementation of new ones will result in a substantial fraction of the at-reactor spent fuel inventory in dry storage canisters by 1998 and beyond. Since this same technology is readily applicable to the MRS, it is advantageous to transfer canisters directly from the ISFSI to the MRS for storage there without the need to reopen the canisters or rehandle the fuel. A store-only MRS offers the possibility of a simple, economical facility which can more easily be demonstrated to be temporary and environmentally benign. Transportation of an intact canister is feasible in a shipping cask of conventional design that is compatible with existing railcars and railroad interchange rules. The use of canisterized fuel also has advantages for eventual shipment and disposal at the federal repository

Refreshing Rubbers as Customized Photothermal Conversion Materials through Post-Darkening Modeling Production.

Science.gov (United States)

Li, Ruiting; Wang, Zhen; Han, Peng; He, Yonglin; Zhang, Xiaohong; Wang, Yapei

2017-12-19

Organic conjugated polymers with low energy bandgaps are emerging as a particular class of near-infrared (NIR) photothermal conversion materials. However, these polymers routinely possess high phase transition temperatures due to the rigid skeleton and strong intermolecular interactions. Conjugated polymers can rarely be thermally processed at low temperature, especially below 100 °C. This work formulates a concept of post-darkening modeling production (p-DMP) by which the thermoplastic non-conjugated trans-polyisoprene (TPI) is refreshed into a photothermal conversion material with high light use efficiency. Two steps, including the customizable shaping at low temperature and iodine vapor-tailored "darkening", ensure the ease of preparing photothermal conversion devices with desirable topologies. A few characterizations, with the combination of density functional theory (DFT) calculations, provide reasonable explanations for understanding the "darkening" process of TPI in iodine atmosphere. In particular, the p-DMP is successfully extended to three-dimension (3D) printing, opening an avenue to fabricate personalized photothermal products, for example, a sunlight-directed physiotherapy device for healthcare of articular tissues. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

La insurgencia reprimida. Regímenes de Seguridad Nacional contra la revolución

Directory of Open Access Journals (Sweden)

Pedro Rivas Nieto

2010-01-01

Full Text Available En este artículo se estudia tanto el concepto que los regímenes de Seguridad Nacional tenían de la llamada guerra revolucionaria como la respuesta que le dieron. Allá en donde implantaron su dominio -especialmente en el Cono Sur de América- pensaban que las guerras revolucionarias eran nuevas técnicas de lucha más que un tipo definido de guerra, que todas respondían al mismo modelo revolucionario y que eran la estrategia del comunismo internacional para adueñarse del mundo. Por eso atacaron con especial dureza a los movimientos de izquierda, pensando que eran la avanzadilla moscovita para acabar con las democracias latinoamericanas.

Implementation of the NANoREG Safe-by-Design approach for different nanomaterial applications

International Nuclear Information System (INIS)

Micheletti, C; Roman, M; Tedesco, E; Olivato, I; Benetti, F

2017-01-01

The Safe-by-Design (SbD) concept is already in use in different industrial sectors as an integral part of the innovation process management. However, the adopted approach is often limited to design solutions aiming at hazard reduction. Safety is not always considered during the innovation process, mainly due to the lack of knowledge (e.g. in small and medium companies, SMEs) and the lack of dialogue between actors along the innovation chain. The net result is that safety is considered only at the end of the innovation process at the market authorization phase, with potential loss of time and money. This is especially valid for manufactured nanomaterials (MNM) for which the regulatory context is not completely developed, and the safety knowledge is not readily available. In order to contribute to a sustainable innovation process in the nanotechnology field by maximising both benefits and safety, the NANoREG project developed a Safe Innovation approach, based on two elements: the Safe-by-Design approach which aims at including risk assessment into all innovation stages; and the Regulatory Preparedness, focused on the dialogue with stakeholders along the innovation chain. In this work we present some examples about the implementation in our Laboratory of this approach for different MNM applications, covering different steps of the innovation chain. The case studies include: the feasibility study of a medical device including substances, for topical application; the testing of two potential nanotech solutions for the consolidation of cultural heritage artifacts; the testing of coatings already on the market for other uses, which was tested as food contact materials (FCM) to evaluate the conformity to food applications. These three examples represent a good opportunity to show the importance of NANoREG SbD and Safe Innovation Approach in general, for developing new nanotechnology-based products, also highlighting the crucial role of EU ProSafe project in promoting this

Implementation of the NANoREG Safe-by-Design approach for different nanomaterial applications

Science.gov (United States)

Micheletti, C.; Roman, M.; Tedesco, E.; Olivato, I.; Benetti, F.

2017-06-01

The Safe-by-Design (SbD) concept is already in use in different industrial sectors as an integral part of the innovation process management. However, the adopted approach is often limited to design solutions aiming at hazard reduction. Safety is not always considered during the innovation process, mainly due to the lack of knowledge (e.g. in small and medium companies, SMEs) and the lack of dialogue between actors along the innovation chain. The net result is that safety is considered only at the end of the innovation process at the market authorization phase, with potential loss of time and money. This is especially valid for manufactured nanomaterials (MNM) for which the regulatory context is not completely developed, and the safety knowledge is not readily available. In order to contribute to a sustainable innovation process in the nanotechnology field by maximising both benefits and safety, the NANoREG project developed a Safe Innovation approach, based on two elements: the Safe-by-Design approach which aims at including risk assessment into all innovation stages; and the Regulatory Preparedness, focused on the dialogue with stakeholders along the innovation chain. In this work we present some examples about the implementation in our Laboratory of this approach for different MNM applications, covering different steps of the innovation chain. The case studies include: the feasibility study of a medical device including substances, for topical application; the testing of two potential nanotech solutions for the consolidation of cultural heritage artifacts; the testing of coatings already on the market for other uses, which was tested as food contact materials (FCM) to evaluate the conformity to food applications. These three examples represent a good opportunity to show the importance of NANoREG SbD and Safe Innovation Approach in general, for developing new nanotechnology-based products, also highlighting the crucial role of EU ProSafe project in promoting this

Determining flow, recharge, and vadose zone drainage in an unconfined aquifer from groundwater strontium isotope measurements, Pasco Basin, WA

International Nuclear Information System (INIS)

2004-01-01

Strontium isotope compositions (87Sr/86Sr) measured in groundwater samples from 273 wells in the Pasco Basin unconfined aquifer below the Hanford Site show large and systematic variations that provide constraints on groundwater recharge, weathering rates of the aquifer host rocks, communication between unconfined and deeper confined aquifers, and vadose zone-groundwater interaction. The impact of millions of cubic meters of wastewater discharged to the vadose zone (103-105 times higher than ambient drainage) shows up strikingly on maps of groundwater 87Sr/86Sr. Extensive access through the many groundwater monitoring wells at the site allows for an unprecedented opportunity to evaluate the strontium geochemistry of a major aquifer, hosted primarily in unconsolidated sediments, and relate it to both long term properties and recent disturbances. Groundwater 87Sr/86Sr increases systematically from 0.707 to 0.712 from west to east across the Hanford Site, in the general direction of groundwater flow, as a result of addition of Sr from the weathering of aquifer sediments and from diffuse drainage through the vadose zone. The lower 87Sr/86Sr groundwater reflects recharge waters that have acquired Sr from Columbia River Basalts. Based on a steady-state model of Sr reactive transport and drainage, there is an average natural drainage flux of 0-1.4 mm/yr near the western margin of the Hanford Site, and ambient drainage may be up to 30 mm/yr in the center of the site assuming an average bulk rock weathering rate of 10-7.5 g/g/yr

A sensitive pressure sensor for diamond anvil cell experiments up to 2 GPa: FluoSpheres[reg

International Nuclear Information System (INIS)

Picard, Aude; Oger, Phil M.; Daniel, Isabelle; Cardon, Herve; Montagnac, Gilles; Chervin, Jean-Claude

2006-01-01

We present an optical pressure sensor suitable for experiments in diamond anvil cell in the 0.1 MPa-2 GPa pressure range, for temperatures between ambient and 323 K. It is based on the pressure-dependent fluorescence spectrum of FluoSpheres[reg], which are commercially available fluorescent microspheres commonly used to measure blood flow in experimental biology. The fluorescence of microspheres is excited by the 514.5 nm line of an Ar + laser, and the resulting spectrum displays three very intense broad bands at 534, 558, and 598 nm, respectively. The reference wavelength and pressure gauge is that of the first inflection point of the spectrum, located at 525.6±0.2 nm at ambient pressure. It is characterized by an instantaneous and large linear pressure shift of 9.93(±0.08) nm/GPa. The fluorescence of the FluoSpheres[reg] has been investigated as a function of pressure (0.1-4 GPa), temperature (295-343 K), pH (3-12), salinity, and pressure transmitting medium. These measurements show that, for pressures comprised between 0.1 MPa and 2 GPa, at temperatures not exceeding 323 K, at any pH, in aqueous pressure transmitting media, pressure can be calculated from the wavelength shift of two to three beads, according to the relation P=0.100 (±0.001) Δλ i (P) with Δλ i (P)=λ i (P)-λ i (0) and λ i (P) as the wavelength of the first inflection point of the spectrum at the pressure P. This pressure sensor is approximately thirty times more sensitive than the ruby scale and responds instantaneously to pressure variations

Efecto de diferentes regímenes de fertilización sobre la relación fitoplancton-bacteríoplancton en mesocosmos

OpenAIRE

Monserrate Vite, Marita Elizabeth

2003-01-01

Efecto de diferentes regímenes de fertilización sobre la relación fitoplancton-bacterioplancton en mesocosmos Se estudió el efecto de la adición de fertilizantes inorgánicos y orgánicos sobre la relación bacterioplancton – fitoplancton en mesocosmos (24 tanques de una tonelada de capacidad), llenados con agua del canal reservorio de la camaronera COFIMAR (Palmar, Ecuador).

Rate of deformation in the Pasco Basin during the Miocene as determined by distribution of Columbia River basalt flows

International Nuclear Information System (INIS)

Reidel, S.P.; Ledgerwood, R.K.; Myers, C.W.; Jones, M.G.; Landon, R.D.

1980-03-01

Detailed mapping of over 8000 square kilometers and logs from 20 core holes were used to determine the distribution and thickness of basalt flows and interbeds in the Pasco Basin. The data indicate the high-MgO Grande Ronde Basalt and Wanapum Basalt thicken from the northeast to the southwest. Deformation began in late Frenchman Springs time in the Saddle Mountains along a northwest-southeast trend and in Roza time along an east-west trend. By late Wanapum time, basalt flows were more restricted on the east side. Saddle Mountains Basalt flows spread out in the basin from narrow channels to the east. The Umatilla Member entered from the southeast and is confined to the south-central basin, while the Wilbur Creek, Asotin, Esquatzel, Pomona, and Elephant Mountain Members entered from the east and northeast. The distribution of these members is controlled by flow volume, boundaries of other flows, and developing ridges. The Wilbur Creek, Asotin, and Esquatzel flows exited from the basin in a channel along the northern margin of the Umatilla flow, while the Pomona and Elephant Mountain flows exited between Umtanum Ridge and Wallula Gap. The thickness of sedimentary interbeds and basalt flows indicated subsidence and/or uplift began in post-Grande Ronde time (14.5 million years before present) and continued through Saddle Mountains time (10.5 million years before present). Maximum subsidence occurred 40 kilometers (24 miles) north of Richland, Washington with an approximate rate of 25 meters (81 feet) per million years during the eruption of the basalt. Maximum uplift along the developing ridges was 70 meters (230 feet) per million years

Thermal expansion studies on Inconel-600[reg] by high temperature X-ray diffraction

International Nuclear Information System (INIS)

Raju, S.; Sivasubramanian, K.; Divakar, R.; Panneerselvam, G.; Banerjee, A.; Mohandas, E.; Antony, M.P.

2004-01-01

The lattice thermal expansion characteristics of Inconel-600[reg] have been studied by high temperature X-ray diffraction (HT-XRD) technique in the temperature range 298-1200 K. Altogether four experimental runs were conducted on thin foils of about 75-100 μm thickness. The diffraction profiles have been accurately calibrated to offset the shift in 2θ values introduced by sample buckling at elevated temperatures. The corrected lattice parameter data have been used to estimate the instantaneous and mean linear thermal expansion coefficients as a function of temperature. The thermal expansion values estimated in the present study show a fair degree of agreement with other existing dilatometer based bulk thermal expansion estimates. The lattice parameter for this alloy at 300 K is found to be 0.3549(1) nm. The mean linear thermal expansivity is found to be 11.4 x 10 -6 K -1

The effect of flurprimidol on Allium rosenbachianum Reg. forced in pots

Directory of Open Access Journals (Sweden)

Halina Laskowska

2013-04-01

Full Text Available The effect of flurprimidol on Allium rosenbachianum (Reg. flowering and forcing period was studied. Bulbs of 18-20 cm circumference were used in the experiment. Two methods of retardant application were used: bulbs soaking before planting and triple spraying of plants during the vegetation period (in the stage of leaf rosette, open leaves and in the phase of green, ‘sitting’ bud. Flurprimidol was used in the following doses: 15 mg ∙dm -3 , 30 mg ∙dm -3 , 45 mg ∙dm -3 and control (plants treated with distilled water. Bulbs were planted into pots on the 20 th of October and ‘wet cooled’ for 14 weeks in the temperature of 9°C. During forcing in a greenhouse, morphological features of plants were observed. It was noted that flurprimidol may be effectively used for suppressing A. rosenbachianum forced in a greenhouse as a pot plant. Flurprimidol used in concentration of 45 mg ∙dm -3 significantly inhibited growth of shoots and length of flower pedicels and leaves and increased number of flowers in inflorescences at the same time. Soaking bulbs of A. rosenbachianumin flurprimidol solution before planting shortened forcing period by 4 days.

Establishment of the National Nuclear Regulatory Portal (NNRP) as the key element of the Global Nuclear Safety and Security Network and Regulatory Network (GNSSN/RegNet) for sharing of nuclear safety information and knowledge among the Global Expert Community

International Nuclear Information System (INIS)

Kuvshinnikov, A.V.

2011-01-01

The Global Nuclear Safety and Security Network (GNSSN) implements the concept of the Global Nuclear Safety and Security Framework (GNSSF) as outlined in INSAG 21. This is the framework of instruments and resources for achieving and maintaining worldwide a high level of safety and security at nuclear facilities and activities as stated in SF-1 and supporting safety standards or recommendations such as INSAG-12. National efforts are and should be augmented by the activities of a variety of international enterprises that facilitate safety and security. The IAEA standard GS-R-3 requires that information and knowledge is managed as a resource. Further strengthening of GNSSN in particular regulatory networking as intended by GNSSN/RegNet has to be based on current national priorities, on existing regional and thematic networks and on the established mechanisms of international co-operation as presented for example on the websites of the IAEA or the OECD-NEA. Current design and operation of RegNet are flexible enough to accommodate differences in national and international approaches and practices and to facilitate exchange and cooperation on regulatory matters. The main role of GNSSN/RegNet is sharing knowledge and bringing people together to enhance and promote nuclear safety and security. The objectives of GNSSN/RegNet: enhancing safety and security by international cooperation, sharing information and best practices, enabling adequate access to relevant safety and security information and promoting the dissemination of this information, implementing active collaboration in the relevant areas related to safety and security, such as joint projects, peer reviews, enabling synergies among existing networks and initiatives, informing the public on the relevant safety and security areas and the related international collaboration. In the RegNet part of the GNSSN exist the National Nuclear Regulatory Portal (NNRP) which is on one hand a part of the global RegNet and on the

Application of UV and X-Ray radiation for refreshing of old latent fingerprints in the cyanoacrylate fuming technique - preliminary study

International Nuclear Information System (INIS)

Radiceska, Pavlina; Ristova, Mimoza

2013-01-01

The work described below focuses on enhancement/refreshment of older latent fingerprints onto a non porous (glass) surface. The aging of the fingerprints is a major problem of the forensic science, because of the compound’s degradation under the influence of a variety of atmospheric parameters, in addition to the time factor. The humidification extent on the latent fingerprints appeared to be one of the critical factors for the deposition of the cyanoacrylate on the finger-marks, since the unsaturated bonds from lipid content from the latent fingerprints serve as active water condensation centers. In the present work we show results from the enhancement of aged latent fingerprint details by activation of the humidity condensation centers with exposition to UV or X-ray radiation prior to their developing into the cyanoacrylate fuming chamber. The aging of the latent fingerprints on glass surfaces with the time for given conditions was established. A term “critical day” was introduced as the day when the detectable details from the latent fingerprints dropped to one half of the initial number of details, recovered from identical fresh latent fingerprint. As the fingerprints were aged to the “critical day”, one third of the samples were exposed to a UV for 15 minutes, another third to 15 minutes of X-ray radiation and the last third was kept unexposed. All the samples were developed into a single cyanoacrylate fuming process. The results showed that in both UV and X-ray cases, a considerable enhancement/refreshment, in approximately 50% of the aged latent fingerprints, has been achieved with only a short term irradiation (15 minutes). (Author)

Creating field management information systems using microsoft{reg_sign} software

Energy Technology Data Exchange (ETDEWEB)

Handsel-Johnson, P.L.; Schroeder, C.Y.

1995-12-31

A Field management information system (FMIS) was created for the Trinidad Resource Development teams in Amoco`s Intemational Operations Group. This application uses Microsoft Access {reg_sign}2.0 and the other Microsoft Office 4.2 software products. The purpose of this information system is to assist these teams in the management of their producing oil and gas fields. This is accomplished by providing: (1) centralized data storage for a variety of data, such as well, production, engineering and geologic in various forms, including raw, interpreted and derived, (2) customized analysis, planning and reporting tools, such as reservoir performance summaries and dynamic field management plans, and (3) the capability to easily exchange data with a variety of engineering and geoscience analytical software. Additional benefits provided to the Resource Development teams by this approach are: (1) improved data accuracy and accessibility from a centralized, relational database, (2) enhanced efficiency as a result of the application being tailored to the teams` operating environment and work processes, and (3) access to an expanded knowledge base by consolidating information from several fields into one database. In short, this product was developed in response to the Trinidad Resource Development teams` need to improve their data integrity, efficiency and analysis and planning capability. The resultant application is not just a database, but rather, a field management information system.

Development of optical spectrum acquisition with spectrophotometer for characterization of optical radiation sources

International Nuclear Information System (INIS)

Solano Vargas, Alvaro

2013-01-01

An improved process of the data acquisition system is developed with Pasco 750 interface and Pasco OS-8539 spectrophotometer. The optical spectrum and color temperature of incandescent sources available are obtained from the Laboratorio de Fotonica y Tecnologia Laser Aplicada. The procedures developed in the project are recommended to collect data and analyze results. The purchase of a new Software and the interface of Pasco is recommended to have a better operation and update [es

Development of fault parameters for use in risk assessment modeling in the Pasco Basin, Columbia Plateau, South Central Washington: a preliminary study

International Nuclear Information System (INIS)

Caggiano, J.A.

1982-03-01

Preliminary data on strain rate, seismicity, and estimated earthquake source parameters suggest limitations on the extent of postulated faulting and its impact on a nuclear waste repository in Columbia River basalt. Structural relief of dated basalt flows, attitude of Pliocene sediments, geodetic surveys, size and distribution of earthquakes, and focal mechanism solutions indicate that deformation of basalt under north-south compression was under way in the Miocene and has continued on existing structures at an average rate of much less than 1 mm/yr in the Pasco Basin. Lengths and displacements of mapped faults suggest limits on the postulated fault that could intersect a repository and produce an earthquake of about magnitude 6.5. Using a credible earthquake permits calculation of preliminary source parameters for risk assessment modeling during a single episode of slip on the postulated new fault and indicates displacement of less than or equal to 1, m on a steeply dipping fault of less than or equal to 50 km length could occur. Preliminary source parameter calculations suggest that displacements of less than or equal to 2 cm may occur during microearthquakes in swarms. The area of fault rupture may be tens of square meters up to a few square kilometers, suggesting slip on joints. Seismic moments for postulated earthquakes in the interconnecting fault and microearthquake scenarios compare favorably with reported values for similar-sized earthquakes in different media and suggest that the estimated fault parameters are reasonable until an adequate tectonic model has been developed

Projected effects of vegetation feedbacks on drought characteristics with SPEI over West Africa using the RegCM-CLM-CN-DV

Science.gov (United States)

Jaehyeong, L.; Kim, Y.; Erfanian, A.; Wang, G.; Um, M. J.

2017-12-01

This study utilizes the Standardized Precipitation-Evapotranspiration Index (SPEI) to investigate the projected effect of vegetation feedbacks on drought in West Africa using the Regional Climate Model coupled to the NCAR Community Land Model with both the Carbon and Nitrogen module (CN) and Dynamic Vegetation module (DV) activated (RegCM-CLM-CN-DV). The role of vegetation feedbacks is examined based on simulations with and without dynamic vegetation. The four different future climate scenarios from CCSM, GFDL, MIROC and MPI are used as the boundary conditions of RegCM for two historical and future periods, i.e., for 1981 to 2000 and for 2081 to 2100, respectively. Using SPEI, the duration, frequency, severity and spatial extents are quantified over West Africa and analyzed for two regions of the Sahel and the Gulf of Guinea. In this study, we find that the estimated annual SPEIs clearly indicate that the projected future droughts over the Sahel are enhanced and prolonged when DV is activated. The opposite is shown over the Gulf of Guinea in general. AcknowledgementsThis work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2015R1C1A2A01054800), by the Korea Meteorological Administration R&D Program under Grant KMIPA 2015-6180 and by the Yonsei University Future-leading Research Initiative of 2015(2016-22-0061).

Short-term retention of a single word relies on retrieval from long-term memory when both rehearsal and refreshing are disrupted.

Science.gov (United States)

Rose, Nathan S; Buchsbaum, Bradley R; Craik, Fergus I M

2014-07-01

Many working memory (WM) models propose that the focus of attention (or primary memory) has a capacity limit of one to four items, and therefore, that performance on WM tasks involves retrieving some items from long-term (or secondary) memory (LTM). In the present study, we present evidence suggesting that recall of even one item on a WM task can involve retrieving it from LTM. The WM task required participants to make a deep (living/nonliving) or shallow ("e"/no "e") level-of-processing (LOP) judgment on one word and to recall the word after a 10-s delay on each trial. During the delay, participants either rehearsed the word or performed an easy or a hard math task. When the to-be-remembered item could be rehearsed, recall was fast and accurate. When it was followed by a math task, recall was slower, error-prone, and benefited from a deeper LOP at encoding, especially for the hard math condition. The authors suggest that a covert-retrieval mechanism may have refreshed the item during easy math, and that the hard math condition shows that even a single item cannot be reliably held in WM during a sufficiently distracting task--therefore, recalling the item involved retrieving it from LTM. Additionally, performance on a final free recall (LTM) test was better for items recalled following math than following rehearsal, suggesting that initial recall following math involved elaborative retrieval from LTM, whereas rehearsal did not. The authors suggest that the extent to which performance on WM tasks involves retrieval from LTM depends on the amounts of disruption to both rehearsal and covert-retrieval/refreshing maintenance mechanisms.

Anti-IL-2 treatment impairs the expansion of T(reg cell population during acute malaria and enhances the Th1 cell response at the chronic disease.

Directory of Open Access Journals (Sweden)

Cláudia A Zago

Full Text Available Plasmodium chabaudi infection induces a rapid and intense splenic CD4(+ T cell response that contributes to both disease pathogenesis and the control of acute parasitemia. The subsequent development of clinical immunity to disease occurs concomitantly with the persistence of low levels of chronic parasitemia. The suppressive activity of regulatory T (T(reg cells has been implicated in both development of clinical immunity and parasite persistence. To evaluate whether IL-2 is required to induce and to sustain the suppressive activity of T(reg cells in malaria, we examined in detail the effects of anti-IL-2 treatment with JES6-1 monoclonal antibody (mAb on the splenic CD4(+ T cell response during acute and chronic P. chabaudi AS infection in C57BL/6 mice. JES6-1 treatment on days 0, 2 and 4 of infection partially inhibits the expansion of the CD4(+CD25(+Foxp3(+ cell population during acute malaria. Despite the concomitant secretion of IL-2 and expression of high affinity IL-2 receptor by large CD4(+ T cells, JES6-1 treatment does not impair effector CD4(+ T cell activation and IFN-γ production. However, at the chronic phase of the disease, an enhancement of cellular and humoral responses occurs in JES6-1-treated mice, with increased production of TNF-α and parasite-specific IgG2a antibodies. Furthermore, JES6-1 mAb completely blocked the in vitro proliferation of CD4(+ T cells from non-treated chronic mice, while it further increased the response of CD4(+ T cells from JES6-1-treated chronic mice. We conclude that JES6-1 treatment impairs the expansion of T(reg cell population during early P. chabaudi malaria and enhances the Th1 cell response in the late phase of the disease.

Coca-Cola Refreshments Class 8 Diesel Electric Hybrid Tractor Evaluation: 13-Month Final Report

Energy Technology Data Exchange (ETDEWEB)

Walkowicz, K.; Lammert, M.; Curran, P.

2012-08-01

This 13-month evaluation used five Kenworth T370 hybrid tractors and five Freightliner M2106 standard diesel tractors at a Coca Cola Refreshments facility in Miami, Florida. The primary objective was to evaluate the fuel economy, emissions, and operational field performance of hybrid electric vehicles when compared to similar-use conventional diesel vehicles. A random dispatch system ensures the vehicles are used in a similar manner. GPS logging, fueling, and maintenance records and laboratory dynamometer testing are used to evaluate the performance of these hybrid tractors. Both groups drive similar duty cycles with similar kinetic intensity (0.95 vs. 0.69), average speed (20.6 vs. 24.3 mph), and stops per mile (1.9 vs. 1.5). The study demonstrated the hybrid group had a 13.7% fuel economy improvement over the diesel group. Laboratory fuel economy and field fuel economy study showed similar trends along the range of KI and stops per mile. Hybrid maintenance costs were 51% lower per mile; hybrid fuel costs per mile were 12% less than for the diesels; and hybrid vehicle total cost of operation per mile was 24% less than the cost of operation for the diesel group.

A comparative evaluation of IONSIV reg-sign IE-911 and chabazite zeolite for the removal of radiostrontium and cesium from wastewater

International Nuclear Information System (INIS)

Bostick, D.T.; DePaoli, S.M.; Guo, B.

1998-01-01

Natural chabazite zeolite was selected as the baseline treatment technology for the removal of fission products, namely 90 Sr and 137 Cs, from near-neutral-pH process wastewater and groundwater. The sorbent IONSIV reg-sign IE-911, a crystalline silicotitanate manufactured by UOP, was recently tested in this capacity and found to compare extremely well against the baseline material. This paper presents and compares the results of similar batch and column tests performed using both materials, and summarizes the physical and chemical characteristics of the sorbents

Regional climate modeling over the Maritime Continent: Assessment of RegCM3-BATS1e and RegCM3-IBIS

Science.gov (United States)

Gianotti, R. L.; Zhang, D.; Eltahir, E. A.

2010-12-01

Despite its importance to global rainfall and circulation processes, the Maritime Continent remains a region that is poorly simulated by climate models. Relatively few studies have been undertaken using a model with fine enough resolution to capture the small-scale spatial heterogeneity of this region and associated land-atmosphere interactions. These studies have shown that even regional climate models (RCMs) struggle to reproduce the climate of this region, particularly the diurnal cycle of rainfall. This study builds on previous work by undertaking a more thorough evaluation of RCM performance in simulating the timing and intensity of rainfall over the Maritime Continent, with identification of major sources of error. An assessment was conducted of the Regional Climate Model Version 3 (RegCM3) used in a coupled system with two land surface schemes: Biosphere Atmosphere Transfer System Version 1e (BATS1e) and Integrated Biosphere Simulator (IBIS). The model’s performance in simulating precipitation was evaluated against the 3-hourly TRMM 3B42 product, with some validation provided of this TRMM product against ground station meteorological data. It is found that the model suffers from three major errors in the rainfall histogram: underestimation of the frequency of dry periods, overestimation of the frequency of low intensity rainfall, and underestimation of the frequency of high intensity rainfall. Additionally, the model shows error in the timing of the diurnal rainfall peak, particularly over land surfaces. These four errors were largely insensitive to the choice of boundary conditions, convective parameterization scheme or land surface scheme. The presence of a wet or dry bias in the simulated volumes of rainfall was, however, dependent on the choice of convection scheme and boundary conditions. This study also showed that the coupled model system has significant error in overestimation of latent heat flux and evapotranspiration from the land surface, and

Stochastic Approaches Within a High Resolution Rapid Refresh Ensemble

Science.gov (United States)

Jankov, I.

2017-12-01

It is well known that global and regional numerical weather prediction (NWP) ensemble systems are under-dispersive, producing unreliable and overconfident ensemble forecasts. Typical approaches to alleviate this problem include the use of multiple dynamic cores, multiple physics suite configurations, or a combination of the two. While these approaches may produce desirable results, they have practical and theoretical deficiencies and are more difficult and costly to maintain. An active area of research that promotes a more unified and sustainable system is the use of stochastic physics. Stochastic approaches include Stochastic Parameter Perturbations (SPP), Stochastic Kinetic Energy Backscatter (SKEB), and Stochastic Perturbation of Physics Tendencies (SPPT). The focus of this study is to assess model performance within a convection-permitting ensemble at 3-km grid spacing across the Contiguous United States (CONUS) using a variety of stochastic approaches. A single physics suite configuration based on the operational High-Resolution Rapid Refresh (HRRR) model was utilized and ensemble members produced by employing stochastic methods. Parameter perturbations (using SPP) for select fields were employed in the Rapid Update Cycle (RUC) land surface model (LSM) and Mellor-Yamada-Nakanishi-Niino (MYNN) Planetary Boundary Layer (PBL) schemes. Within MYNN, SPP was applied to sub-grid cloud fraction, mixing length, roughness length, mass fluxes and Prandtl number. In the RUC LSM, SPP was applied to hydraulic conductivity and tested perturbing soil moisture at initial time. First iterative testing was conducted to assess the initial performance of several configuration settings (e.g. variety of spatial and temporal de-correlation lengths). Upon selection of the most promising candidate configurations using SPP, a 10-day time period was run and more robust statistics were gathered. SKEB and SPPT were included in additional retrospective tests to assess the impact of using

The Fluorine Gauche Effect Explained by Electrostatic Polarization Instead of Hyperconjugation: An Interacting Quantum Atoms (IQA) and Relative Energy Gradient (REG) Study

OpenAIRE

Thacker, Joseph; Popelier, Paul

2018-01-01

We present an interacting quantum atoms (IQA) study of the gauche effect by comparing 1,2-difluoroethane, 1,2-dichloroethane, and three conformers of 1,2,3,4,5,6-hexafluorocyclohexane. In the 1,2-difluoroethane, the gauche effect is observed in that the gauche conformation is more stable than the anti, whereas in 1,2-dichloroethane the opposite is true. The analysis performed here is exhaustive and unbiased thanks to using the recently introduced relative energy gradient (REG) method [Thacker...

Assessment of TEES{reg_sign} applications for Wet Industrial Wastes: Energy benefit and economic analysis report

Energy Technology Data Exchange (ETDEWEB)

Elliott, D.C.; Scheer, T.H.

1992-02-01

Fundamental work is catalyzed biomass pyrolysis/gasification led to the Thermochemical Environmental Energy System (TEES{reg_sign}) concept, a means of converting moist biomass feedstocks to high-value fuel gases such as methane. A low-temperature (350{degrees}C), pressurized (3100 psig) reaction environment and a nickel catalyst are used to reduce volumes of very high-moisture wastes such as food processing byproducts while producing useful quantities of energy. A study was conducted to assess the economic viability of a range of potential applications of the process. Cases examined included feedstocks of cheese whey, grape pomace, spent grain, and an organic chemical waste stream. The analysis indicated that only the organic chemical waste process is economically attractive in the existing energy/economic environment. However, food processing cases will become attractive as alternative disposal practices are curtailed and energy prices rise.

Assessment of TEES reg sign applications for Wet Industrial Wastes: Energy benefit and economic analysis report

Energy Technology Data Exchange (ETDEWEB)

Elliott, D.C.; Scheer, T.H.

1992-02-01

Fundamental work is catalyzed biomass pyrolysis/gasification led to the Thermochemical Environmental Energy System (TEES{reg sign}) concept, a means of converting moist biomass feedstocks to high-value fuel gases such as methane. A low-temperature (350{degrees}C), pressurized (3100 psig) reaction environment and a nickel catalyst are used to reduce volumes of very high-moisture wastes such as food processing byproducts while producing useful quantities of energy. A study was conducted to assess the economic viability of a range of potential applications of the process. Cases examined included feedstocks of cheese whey, grape pomace, spent grain, and an organic chemical waste stream. The analysis indicated that only the organic chemical waste process is economically attractive in the existing energy/economic environment. However, food processing cases will become attractive as alternative disposal practices are curtailed and energy prices rise.

Refreshing the Aged Latent Fingerprints with Ionizing Radiation Prior to the Cyanoacrylate Fuming Procedure: A Preliminary Study.

Science.gov (United States)

Ristova, Mimoza M; Radiceska, Pavlina; Bozinov, Igorco; Barandovski, Lambe

2016-05-01

One of the crucial factors determining the cyanoacrylate deposit quality over latent fingerprints appeared to be the extent of the humidity. This work focuses on the enhancement/refreshment of age-degraded latent fingerprints by irradiating the samples with UV, X-ray, or thermal neutrons prior to the cyanoacrylate (CA) fuming. Age degradation of latent fingerprints deposited on glass surfaces was examined through the decrease in the number of characteristic minutiae counts over time. A term "critical day" was introduced for the time at which the average number of identifiable minutiae definitions drops to one-half. Fingerprints older than their "critical day" were exposed to either UV, X-ray, or thermal neutrons. Identical reference samples were kept unexposed. All samples, both reference and irradiated, were developed during a single CA fuming procedure. Comparative latent fingerprint analysis showed that exposure to ionizing radiation enhances the CA fuming, yielding a 20-30% increase in average minutiae count. © 2015 American Academy of Forensic Sciences.

Applicability of 1994-1995 USRADS reg-sign surveys of Bear Creek Valley flood plain and Operable Unit 1 to the radiological characterization of Y-12 grassy/wooded areas

International Nuclear Information System (INIS)

Bogard, J.S.; Hamm, R.N.; Brown, K.S.

1997-03-01

This document, provided in support of the Y-12 Site Radiological Characterization Study, analyzes the utility of data from two reports by Chemrad Tennessee Corporation in identifying radiological contamination in excess of contamination control guidelines at the surface of soils in the Bear Creek Valley Flood Plain (BCVFP) and in Y-12 Operable Unit 1 (OU1). The Chemrad reports were developed under subcontract to Science Applications International Corporation for their remedial investigation of these sites for Martin Marietta Energy Systems Environmental Restoration Division. Surveys were performed by Chemrad using the UltraSonic Ranging and Data System (USRADS reg-sign), which utilizes ultrasonic triangulation to determine the location of a survey technician at the same time that radiological monitoring data are telemetered from his instruments to a remote receiving station. Floor monitor and Geiger-Mueller pancake meter results from the USRADS reg-sign surveys are shown to be sufficiently precise to reliably detect contamination in excess of the limiting radioactivity value of 1,000 dpm/100 cm 2 for removable uranium contamination specified in 10 CFR 835 Appendix D. MicroRem meter survey results, also included as part of the USRADS reg-sign surveys, indicate that the derived limiting value of 56.8 μrem/h for penetrating dose at 1 m (corresponding to 100 mrem/γ) was not exceeded. However, both the pancake meter and floor monitor results suggest that surface contamination exceeding 1,000 dpm/100 cm 2 is not uncommon. Sites in OU1 and BCVFP were visited, and independent surveys made with hand-held instruments, to confirm conclusions about the USRADS close-quote survey results and to verify that these results are from contamination uniformly distributed on the soil surface, and not from discrete sources which are not likely transferred to shoes, vehicles, or clothing

Measurement and modeling of residual stress in a welded Haynes[reg] 25 cylinder

International Nuclear Information System (INIS)

Larsson, C.; Holden, T.M.; Bourke, M.A.M.; Stout, M.; Teague, J.; Lindgren, L.-E.

2005-01-01

An experimental and simulation study of residual stresses was made in the vicinity of a gas tungsten arc weld, used to join a hemispherical end cap to a cylinder. The capped cylinder is used in a satellite application and was fabricated from a Co-based Haynes[reg] 25 alloy. The cylinder was 34.7 mm in outer diameter and 3.3 mm in thickness. The experimental measurements were made by neutron diffraction and the simulation used the implicit Marc finite element code. The experimental resolution was limited to approximately 3 mm parallel to the axis of the cylinder (the weld was 6 mm in the same direction) and comparison over the same volume of the finite element prediction showed general agreement. Subject to the limited spatial resolution, the largest experimentally measured tensile residual stress was 180 MPa, located at the middle of the weld. However, the predictions suggest that there are regions in the weld where average tensile residual stresses as much as 400 MPa exist. One qualitative disparity between the model and the experiments was that the measurement included a larger degree of asymmetry on either side of the weld than predicted by the model

Measurement and modeling of residual stress in a welded Haynes[reg] 25 cylinder

Energy Technology Data Exchange (ETDEWEB)

Larsson, C. [Div. of Eng. Mat., Department of Mech. Eng., Linkoeping University, 58183 Linkoeping (Sweden)]. E-mail: clarsson@cfl.rr.com; Holden, T.M. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Bourke, M.A.M. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Stout, M. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Teague, J. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Lindgren, L.-E. [Div. Comp. Aided Design, Lulea University of Technology and Dalarna University, 97187 Lulea (Sweden)

2005-06-15

An experimental and simulation study of residual stresses was made in the vicinity of a gas tungsten arc weld, used to join a hemispherical end cap to a cylinder. The capped cylinder is used in a satellite application and was fabricated from a Co-based Haynes[reg] 25 alloy. The cylinder was 34.7 mm in outer diameter and 3.3 mm in thickness. The experimental measurements were made by neutron diffraction and the simulation used the implicit Marc finite element code. The experimental resolution was limited to approximately 3 mm parallel to the axis of the cylinder (the weld was 6 mm in the same direction) and comparison over the same volume of the finite element prediction showed general agreement. Subject to the limited spatial resolution, the largest experimentally measured tensile residual stress was 180 MPa, located at the middle of the weld. However, the predictions suggest that there are regions in the weld where average tensile residual stresses as much as 400 MPa exist. One qualitative disparity between the model and the experiments was that the measurement included a larger degree of asymmetry on either side of the weld than predicted by the model.

The integration of novel EAP-based Braille cells for use in a refreshable tactile display

Science.gov (United States)

Di Spigna, N.; Chakraborti, P.; Winick, D.; Yang, P.; Ghosh, T.; Franzon, P.

2010-04-01

Structures demonstrating the viability of both the hydraulic and latching Braille dot, and the dielectric elastomer fiber Braille dot have been fabricated and characterized. A hydraulic proof-of-concept structure has achieved the necessary volumetric change required to lift a Braille dot over 0.5mm at voltages under 1000V and at speeds under 100ms. Long bimorphs have been fabricated that demonstrate large tip displacements over 2mm that could be used to mechanically latch the Braille rod in the 'up' position to achieve the force requirement. The addition of radial prestrain in dielectric elastomer tubes has reduced the wall thickness and directed the strain in the axial direction which has had a dramatic impact on their resulting characteristics. The required bias voltage for the dielectric elastomer fiber Braille dot has been reduced from 15.5kV to 8.75kV while the Braille head tip displacement of a fabricated prototype has almost tripled on average and now also exceeds the required displacement for a refreshable Braille display. Finally, potential solutions to the current shortcomings of both designs in meeting all of the requirements for such a display are discussed.

Colorado SIP: 5 CCR 1001-13, Reg 11, Motor Vehicle Emissions Inspection Program—Part A, General Provisions, Area of Applicability, Schedules for Obtaining Certification of Emissions Control, Definitions, Exemptions, and Clean Screening/Remote Sensing

Science.gov (United States)

Colorado SIP: 5 CCR 1001-13, Reg 11, Motor Vehicle Emissions Inspection Program—Part A, General Provisions, Area of Applicability, Schedules for Obtaining Certification of Emissions Control, Definitions, Exemptions, and Clean Screening/Remote Sensing

Cuestión social y regímenes militares. Argentina y Chile durante los años setenta

Directory of Open Access Journals (Sweden)

Gabriela Gomes

2015-01-01

Full Text Available En este artículo se analizan las políticas sociales destinadas a la búsqueda del consenso que llevaron adelante la Secretaría de Estado de Promoción y Asistencia a la Comunidad del Ministerio de Bienestar Social durante la “Revolución Argentina” (1966-1973 y la Dirección de Organizaciones Civiles y el Ministerio del Interior durante la dictadura chilena (1973-1988. El abordaje propuesto apunta a complejizar la noción de Estado burocrático autoritario, puesto que se considera como hipótesis que ambos regímenes no solo se dedicaron a reprimir las actividades políticas de los sectores populares, sino que buscaron reorganizarlos bajo nuevas coordenadas sociales.

Cloud archiving and data mining of High-Resolution Rapid Refresh forecast model output

Science.gov (United States)

Blaylock, Brian K.; Horel, John D.; Liston, Samuel T.

2017-12-01

Weather-related research often requires synthesizing vast amounts of data that need archival solutions that are both economical and viable during and past the lifetime of the project. Public cloud computing services (e.g., from Amazon, Microsoft, or Google) or private clouds managed by research institutions are providing object data storage systems potentially appropriate for long-term archives of such large geophysical data sets. We illustrate the use of a private cloud object store developed by the Center for High Performance Computing (CHPC) at the University of Utah. Since early 2015, we have been archiving thousands of two-dimensional gridded fields (each one containing over 1.9 million values over the contiguous United States) from the High-Resolution Rapid Refresh (HRRR) data assimilation and forecast modeling system. The archive is being used for retrospective analyses of meteorological conditions during high-impact weather events, assessing the accuracy of the HRRR forecasts, and providing initial and boundary conditions for research simulations. The archive is accessible interactively and through automated download procedures for researchers at other institutions that can be tailored by the user to extract individual two-dimensional grids from within the highly compressed files. Characteristics of the CHPC object storage system are summarized relative to network file system storage or tape storage solutions. The CHPC storage system is proving to be a scalable, reliable, extensible, affordable, and usable archive solution for our research.

La marea autoritaria: nacimiento, desarrollo y consolidación de regímenes parafascistas en Austria y España

Directory of Open Access Journals (Sweden)

Miguel Ángel del Arco Blanco

2009-12-01

Full Text Available En el presente trabajo se explica el nacimiento y propagación de los movimientos fascistas a partir de las secuelas de la I Guerra Mundial y del escenario político y social que le siguió. Los casos que analizamos en el presente trabajo, Austria y España, encajan perfectamente en ese contexto; y de ello deriva el interés de su estudio para la comprensión de la llegada e implantación del fascismo en Europa, así como del parafascismo (regímenes que, aunque no fueron plenamente fascistas, sí compartieron algunas características y fueron fuertemente influenciados por el fascismo en su nacimiento, implantación y consolidación. El análisis y comparación de regímenes como el Ständestaat y el franquista quizá pongan de manifiesto que el parafascismo pudo ser más la norma que la excepción a la alternativa plenamente fascista en la Europa de entreguerras.______________________ABSTRACT:The present work tries to explain the birth and the spread of facist movements from the consequences of theFirst World War and the political and social scene that followed it. The cases that we analyzed in this work, Austria and Spain, fit perfectly in that context; this kind of analysis facilitates the understanding of the coming and implantation of fascism in Europe, as well as of parafascism phenomenon (a kind of regime that, although is not totally facist, it shares some characteristics and is strongly influenced by the fascism in its birth, implantation and consolidation. The analysis and comparison of regimes just as the Ständestaat and the Franquista's one can show that the parafascism could be the norm in lieu of the exception to the totally facist alternative in the inter-war Europe.

Spearfishing regulation benefits artisanal fisheries: the ReGS indicator and its application to a multiple-use Mediterranean marine protected area.

Science.gov (United States)

Rocklin, Delphine; Tomasini, Jean-Antoine; Culioli, Jean-Michel; Pelletier, Dominique; Mouillot, David

2011-01-01

The development of fishing efficiency coupled with an increase of fishing effort led to the overexploitation of numerous natural marine resources. In addition to this commercial pressure, the impact of recreational activities on fish assemblages remains barely known. Here we examined the impact of spearfishing limitation on resources in a marine protected area (MPA) and the benefit it provides for the local artisanal fishery through the use of a novel indicator. We analysed trends in the fish assemblage composition using artisanal fisheries data collected in the Bonifacio Strait Natural Reserve (BSNR), a Mediterranean MPA where the spearfishing activity has been forbidden over 15% of its area. Fish species were pooled into three response groups according to their target level by spearfishing. We developed the new flexible ReGS indicator reflecting shifts in species assemblages according to the relative abundance of each response group facing external pressure. The catch per unit effort (CPUE) increased by ca. 60% in the BSNR between 2000 and 2007, while the MPA was established in 1999. The gain of CPUE strongly depended on the considered response group: for the highly targeted group, the CPUE doubled while the CPUE of the untargeted group increased by only 15.5%. The ReGS value significantly increased from 0.31 to 0.45 (on a scale between 0 and 1) in the general perimeter of this MPA while it has reached a threshold of 0.43, considered as a reference point, in the area protected from spearfishing since 1982. Our results demonstrated that limiting recreational fishing by appropriate zoning in multiple-use MPAs represents a real benefit for artisanal fisheries. More generally we showed how our new indicator may reveal a wide range of impacts on coastal ecosystems such as global change or habitat degradation.

Spearfishing regulation benefits artisanal fisheries: the ReGS indicator and its application to a multiple-use Mediterranean marine protected area.

Directory of Open Access Journals (Sweden)

Delphine Rocklin

Full Text Available The development of fishing efficiency coupled with an increase of fishing effort led to the overexploitation of numerous natural marine resources. In addition to this commercial pressure, the impact of recreational activities on fish assemblages remains barely known. Here we examined the impact of spearfishing limitation on resources in a marine protected area (MPA and the benefit it provides for the local artisanal fishery through the use of a novel indicator. We analysed trends in the fish assemblage composition using artisanal fisheries data collected in the Bonifacio Strait Natural Reserve (BSNR, a Mediterranean MPA where the spearfishing activity has been forbidden over 15% of its area. Fish species were pooled into three response groups according to their target level by spearfishing. We developed the new flexible ReGS indicator reflecting shifts in species assemblages according to the relative abundance of each response group facing external pressure. The catch per unit effort (CPUE increased by ca. 60% in the BSNR between 2000 and 2007, while the MPA was established in 1999. The gain of CPUE strongly depended on the considered response group: for the highly targeted group, the CPUE doubled while the CPUE of the untargeted group increased by only 15.5%. The ReGS value significantly increased from 0.31 to 0.45 (on a scale between 0 and 1 in the general perimeter of this MPA while it has reached a threshold of 0.43, considered as a reference point, in the area protected from spearfishing since 1982. Our results demonstrated that limiting recreational fishing by appropriate zoning in multiple-use MPAs represents a real benefit for artisanal fisheries. More generally we showed how our new indicator may reveal a wide range of impacts on coastal ecosystems such as global change or habitat degradation.

Electron spin resonance characterization of trapping centers in Unibond reg-sign buried oxides

International Nuclear Information System (INIS)

Conley, J.F. Jr.; Lenahan, P.M.; Wallace, B.D.

1996-01-01

Electron spin resonance and capacitance vs. voltage measurements are used to evaluate the radiation response of Unibond buried oxides. When damaged by hole injection, it is found that Unibond reg-sign buried oxides exhibit a rough correspondence between E' centers and positive charge as well as generation of P b centers at the Unibond buried oxide/Si interface. In these respects, Unibond buried oxides qualitatively resemble thermal SiO 2 . However, a hydrogen complexed E' center known as the 74 G doublet is also detected in the Unibond buried oxides. This defect is not detectable in thermal SiO 2 under similar circumstances. Since the presence of 74 G doublet center is generally indicative of very high hydrogen content and since hydrogen is clearly a significant participant in radiation damage, this result suggests a qualitative difference between the radiation response of Unibond and thermal SiO 2 . Unibond results are also compared and contrasted with similar investigations on separation-by-implanted-oxygen (SIMOX) buried oxides. Although the charge trapping response of Unibond buried oxides may be inferior to that of radiation hardened thermal SiO 2 , it appears to be more simple and superior to that of SIMOX buried oxides

Regímenes estacionales de precipitación en la vertiente mediterránea de la Península Ibérica

OpenAIRE

Luis Arrillaga, Martín de; González Hidalgo, José Carlos; Longares, Luis Alberto; Stepanek, Petr

2008-01-01

Ponencia presentada en: VI Congreso Internacional de la Asociación Española de Climatología celebrado en Tarragona del 8 al 11 de octubre de 2008. [ES]En este trabajo analizamos los regímenes estacionales de precipitación de la fachada Mediterránea de la Península Ibérica empleando la base de datos de precipitaciones mensuales MOPREDAMES (1113 series mensuales; periodo 1951-2000). En cada observatorio se estimó el régimen de precipitación promedio y anualmente se calculó el régime...

Assessment of ethanol-fueled IMHEX{reg_sign} fuel cell power plants in distributed generation

Energy Technology Data Exchange (ETDEWEB)

Woods, R. [M-C Power Corp., Burr Ridge, IL (United States); Lefeld, J. [PSI Energy, Plainfield, IN (United States)

1993-12-31

Ethanol-fueled cell power plants presents several significant opportunities for the power generation industry. The potential exists to reduce pollution, help the nation shift from its dependence on imported fuels, reduce global warming, and strengthen the economy. Two important developments can be merged to create a clean, high-technology, bio-based energy system: the production of ethanol fuels and the application of fuel cell power plants. Utilization of ethanol will be in dual-fueled applications initially, and evolve toward the primary fuel as the need for renewable energy sources increase and the economic competitiveness improves. This assessment addresses the major issues of this proposed concept and outlines the benefits anticipated to the environment, US agriculture, energy supplies, and electric power customers. Economic and technical aspects of the concept are also reviewed. One of PSI Energy`s primary interests is the utilization of renewable fuels supplied by their customer base. The IMHEX{reg_sign} fuel cell is an advanced electric power generation technology currently under development by M-C Power. Commercial applications within the power generation industry are scheduled to begin during the late 1990s.

Gyrineum natator: A potential indicator of imposex along the Indian coast

Digital Repository Service at National Institute of Oceanography (India)

Vishwakiran, Y.; Anil, A.C.; Venkat, K.; Sawant, S.S.

.E., Bryan, G.W., Pascoe, P.L., Burt, G.R., 1987. The use of the dog-whelk, Nucella lapillus, as an indicator of tributyltin (TBT) contamination. J. Mar. Biol. Assoc. UK 67, 507–523. Gibbs, P.E., Bryan, G.W., Pascoe, P.L., Burt, G.R., 1990. Reproductive...

In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression.

Directory of Open Access Journals (Sweden)

Che-Ming Liu

Full Text Available Cancer cells respond to stress by activating a variety of survival signaling pathways. A disintegrin and metalloproteinase (ADAM 9 is upregulated during cancer progression and hormone therapy, functioning in part through an increase in reactive oxygen species. Here, we present in vitro and in vivo evidence that therapeutic targeting of ADAM9 gene expression by lentivirus-delivered small hairpin RNA (shRNA significantly inhibited proliferation of human prostate cancer cell lines and blocked tumor growth in a murine model of prostate cancer bone metastasis. Cell cycle studies confirmed an increase in the G1-phase and decrease in the S-phase population of cancer cells under starvation stress conditions, which correlated with elevated intracellular superoxide levels. Microarray data showed significantly decreased levels of regenerating islet-derived family member 4 (REG4 expression in prostate cancer cells with knockdown of ADAM9 gene expression. This REG4 downregulation also resulted in induction of expression of p21(Cip1/WAF1, which negatively regulates cyclin D1 and blocks the G1/S transition. Our data reveal a novel molecular mechanism of ADAM9 in the regulation of prostate cancer cell proliferation, and suggests a combined modality of ADAM9 shRNA gene therapy and cytotoxic agents for hormone refractory and bone metastatic prostate cancer.

A rapid and efficient preparation of [{sup 123}I]radiopharmaceuticals using a small HPLC Rocket[reg] column

Energy Technology Data Exchange (ETDEWEB)

Katsifis, Andrew [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia)]. E-mail: akx@ansto.gov.au; Papazian, Vahan [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia); Jackson, Timothy [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia); Loc' h, Christian [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia)

2006-01-01

A simplified method for the rapid and efficient preparation of [{sup 123}I]radiopharmaceuticals is described. Three radiopharmaceuticals, [{sup 123}I]{beta}-CIT, [{sup 123}I]MIBG and [{sup 123}I]clioquinol, were synthesised and purified as model compounds. The radiotracers were labelled with iodine-123 using electrophilic oxidative conditions and purified by a compact semi-preparative reverse phase column (C-18, 3 {mu}m, 7x53 mm, Alltima Rocket[reg, Alltech] using aqueous-ethanol as HPLC solvents that were directly used for radiopharmaceutical formulation. The radiochemical purity of the radioiodinated tracers as assessed by analytical HPLC was higher than 99% with specific activity higher than 3 GBq/nmol. The total preparation time of a radiotracer ranged from 40 to 60 min and, starting from 3.7 GBq of iodine-123, more than 2.5 GBq of formulated radiopharmaceuticals were available for clinical investigations.

Linde Rectiscol{reg_sign} process. The most economic and experienced wash process for removal of sulfur compounds and CO{sub 2} from gasification gases

Energy Technology Data Exchange (ETDEWEB)

Kaballo, H.-P.; Kerestceciogly, U. [Linde AG, Hoellriegelskreuth (Germany). Linde Engineering Division

2006-07-01

The Recitsol{reg_sign} wash process is a well-proven process for the removal of H{sub 2}S/COS and CO{sub 2} from coal, asphalt, pitch or oil derived synthesis gas. It is a physical gas wash system using methanol as solvent at operating temperatures below water freezing point, to produce a synthesis gas with less than 0.1 vppm of total sulfur. The CO{sub 2} content can be adjusted in a range from several mol-percent down to a few ppm, as is required by the specified application. Its main advantages are the use of cheap and readily available methanol as solvent, the very flexible process configuration, and rather low utility consumption figures compared with other wash processes, like PEGE based process or chemical washes. A modern concept of a Rectisol{reg_sign} unit is described, to treat shifted and un-shifted gases in just one plant: shifted gas was used for hydrotreating in a refinery. Unshifted gas was used as fuel gas for power generation in an IGCC. CO{sub 2} of the unshifted feed gas was removed only partly, because the remaining CO{sub 2} was fed as inert gas together with the fuel gas to an IGCC. All sulfur compounds of both feed gases were concentrated in one single stream with a high H{sub 2}S concentration. Impurities like NH{sub 3}, HCN or metal carbonyls were eliminated nearly quantitatively. 4 refs., 4 figs., 3 tabs.

Radical, reformist and aborted liberalism: origins of national regimes in Central America Liberalismo radical, reformista y frustrado: orígenes de los regímenes nacionales en América central

Directory of Open Access Journals (Sweden)

James MAHONEY

2011-06-01

Full Text Available During the twentieth century, the countries of Central America were characterized by remarkably different political regimes: military-authoritarianism in Guatemala and El Salvador, progressive democracy in Costa Rica and traditional-authoritarianism in Honduras and Nicaragua. This article explains these contrasting regime outcomes by exploring the agrarian and state-building reforms pursued by political leaders during the nineteenth– and early twentieth century liberal reform period. Based on differences in the transformation of state and class structures, three types of liberalism are identified: radical liberalism in Guatemala and El Salvador, reformist liberalism in Costa Rica and aborted liberalism in Honduras and Nicaragua. It is argued that these types of liberalism set the Central American countries on contrasting paths of political development, culminating in diverse regime outcomes.Durante el siglo XX, los países de América Central se caracterizaron por tener regímenes políticos muy diferentes: el autoritarismo militar en Guatemala y El Salvador; la democracia progresista en Costa Rica y el autoritarismo tradicional en Honduras y Nicaragua. Este artículo explica los resultados de estos distintos regímenes mediante la exploración de las reformas agrarias y de la construcción del Estado llevadas a cabo por los líderes políticos durante el siglo XIX y principios del periodo de reformas liberales del siglo XX. Basándose en las diferencias de la transformación del Estado y de las estructuras de clases, se pueden identificar tres tipos de liberalismo: liberalismo radical en Guatemala y El Salvador; liberalismo reformista en Costa Rica y liberalismo frustrado en Honduras y Nicaragua. Se argumenta que estos tipos de liberalismo condujeron a los países de América Central a caminos contrarios al desarrollo político, culminando así en regímenes con resultados diversos.

Future Projections of Air Temperature and Precipitation for the CORDEX-MENA Domain by Using RegCM4.3.5

Science.gov (United States)

Ozturk, Tugba; Turp, M. Tufan; Türkeş, Murat; Kurnaz, M. Levent

2015-04-01

In this study, the projected changes for the periods of 2016 - 2035, 2046 - 2065, and 2081 - 2100 in the seasonal averages of air temperature and precipitation variables with respect to the reference period of 1981 - 2000 were examined for the Middle East and North Africa region. In this context, Regional Climate Model (RegCM4.3.5) of ICTP (International Centre for Theoretical Physics) was run by using two different global climate models. MPI-ESM-MR global climate model of the Max Planck Institute for Meteorology and HadGEM2 of the Met Office Hadley Centre were dynamically downscaled to 50 km for the CORDEX-MENA domain. The projections were realized according to the RCP4.5 and the RCP8.5 emission scenarios of the IPCC (Intergovernmental Panel of Climate Change).

Chemical and radiation stability of a proprietary cesium ion exchange material manufactured from WWL membrane and SuperLig reg-sign 644

International Nuclear Information System (INIS)

Brown, G.N.; Carson, K.J.; DesChane, J.R.; Elovich, R.J.; Berry, P.K.

1996-09-01

Pretreatment of nuclear process wastes for ion exchange removal of Cs and other radionuclides is one way to minimize amount of high-level radioactive waste at Hanford. This study evaluated Cs-selective SuperLig reg-sign 644 (IBC Advanced Technologies, American Fork UT) entrapped in a proprietary WWL web membrane (3M) for chemical/radiation stability in simulated caustic neutralized current acid waste (NCAW), 0.5M HNO 3 , water, and air. After exposure up to 2.0E+09 rad, the material was evaluated for Cs uptake in 5M sodium NCAW simulants with varying Cs contents. Radiolytic stability appears to be sufficient for ion exchange pretreatment of radioactive Cs: essentially no decrease in Cs selectivity or loading (Kd) was observed during 60 Cs gamma irradiation in water or 0.5M HNO 3 up to 1.0E+09 rad. Cs Kd decreased by a factor of 2 after 2.0E+09 rad exposure. Cs Kd did not change during irradiation in 5M NCAW or ambient air up to 1.0E+08 rad, but decreased by more than an order of magnitude between 1.0E+08 and 2.0E+09 rad (not typical of process conditions). Chemical stability under caustic conditions is lower than in air or under neutral/acidic conditions. Results indicate that this material is less stable in caustic solution irrespective of radiation exposure. Samples of the membrane retained their physical form throughout the entire experiment and were only slightly brittle after exposure to 2.0E+09 rad. (The material evaluated was a finely ground (400 mesh) particulate engineered to form a polymeric fiber (WWL), not the macroscopic form of SuperLig reg-sign 644 resin (20 to 50 mesh).)

Parameterizing Subgrid-Scale Orographic Drag in the High-Resolution Rapid Refresh (HRRR) Atmospheric Model

Science.gov (United States)

Toy, M. D.; Olson, J.; Kenyon, J.; Smirnova, T. G.; Brown, J. M.

2017-12-01

The accuracy of wind forecasts in numerical weather prediction (NWP) models is improved when the drag forces imparted on atmospheric flow by subgrid-scale orography are included. Without such parameterizations, only the terrain resolved by the model grid, along with the small-scale obstacles parameterized by the roughness lengths can have an effect on the flow. This neglects the impacts of subgrid-scale terrain variations, which typically leads to wind speeds that are too strong. Using statistical information about the subgrid-scale orography, such as the mean and variance of the topographic height within a grid cell, the drag forces due to flow blocking, gravity wave drag, and turbulent form drag are estimated and distributed vertically throughout the grid cell column. We recently implemented the small-scale gravity wave drag paramterization of Steeneveld et al. (2008) and Tsiringakis et al. (2017) for stable planetary boundary layers, and the turbulent form drag parameterization of Beljaars et al. (2004) in the High-Resolution Rapid Refresh (HRRR) NWP model developed at the National Oceanic and Atmospheric Administration (NOAA). As a result, a high surface wind speed bias in the model has been reduced and small improvement to the maintenance of stable layers has also been found. We present the results of experiments with the subgrid-scale orographic drag parameterization for the regional HRRR model, as well as for a global model in development at NOAA, showing the direct and indirect impacts.

A passive emergency heat sink for water cooled reactors with particular application to CANDU reg-sign reactors

International Nuclear Information System (INIS)

Spinks, N.J.

1996-01-01

Water in an overhead pool can serve as a general-purpose passive emergency heat sink for water-cooled reactors. It can be used for containment cooling, for emergency depressurization of the heat transport-system, or to receive any other emergency heat, such as that from the CANDU reg-sign moderator. The passive emergency water system provides in-containment depressurization of steam generators and no other provision is needed for supply of low-pressure emergency water to the steam generators. For containment cooling, the pool supplies water to the tube side of elevated tube banks inside containment. The elevation with respect to the reactor heat source maximizes heat transport, by natural convection, of hot containment gases. This effective heat transport combines with the large heat-transfer coefficients of tube banks, to reduce containment overpressure during accidents. Cooled air from the tube banks is directed past the break in the heat-transport system, to facilitate removal of hydrogen using passive catalytic recombiners

Changes in seasonal and diurnal precipitation types during summer over South Korea in the late twenty-first century (2081-2100) projected by the RegCM4.0 based on four RCP scenarios

Science.gov (United States)

Oh, Seok-Geun; Suh, Myoung-Seok

2018-01-01

Changes in seasonal and diurnal precipitation types over South Korea during summer in the late twenty-first century (2081-2100) were projected under four RCP scenarios using the Regional Climate Model (RegCM4.0) with a horizontal resolution of 12.5 km. Two boundary conditions, ERA-Interim and HadGEM2-AO, were used to drive the RegCM4.0 (jointly named RG4_ERA and RG4_HG2, respectively). In general, the RegCM4.0 reproduces the spatial distribution of summer precipitation over Northeast Asia for the current climate (1989-2008) reasonably well. The RG4_HG2 shows larger dry biases over South Korea, when compared with observations, than does the RG4_ERA. These strong dry biases result from the underestimation of convective precipitation (CPR) and are particularly noticeable in late afternoons during July and August. It is related to the performance of HadGEM2-AO which simulated southwesterly winds weakly in that time. However, interestingly, the RG4_HG2 simulates similar increases in the contribution of CPR to total precipitation after mid-July, resulting in comparable performance in the reproduction of heavy precipitation. In the late twenty-first century, a significant increase (decrease) in CPR (NCPR) is generally projected over South Korea, and particularly under the RCP8.5. During June, the total precipitation is affected primarily by changes in NCPR under RCP2.6 and RCP6.0. After mid-July, increasing total precipitation is primarily caused by the distinct increases in CPR in the late afternoons; this pattern is particularly noticeable under RCP8.5, which is associated with more destabilized atmospheric conditions during July and August. Light and heavy precipitation are projected to decrease and increase, respectively, under RCP8.5.

Impact of Dust on Air Quality and Radiative Forcing : AN Episodic Study for the Megacity Istanbul Using RegCM4.1

Science.gov (United States)

Agacayak, T.; Kindap, T.; Unal, A.; Mallet, M.; Pozzoli, L.; Karaca, M.; Solmon, F.

2012-04-01

Istanbul is a megacity (with population over 15 million) that has significant levels of Particulate Matter concentrations. It is suspected that long-range transport of Saharan dust is one of the main contributors. The purpose of this study is to investigate the relationship between high PM concentrations and dust transport using atmospheric modeling, satellite data as well as in-situ observations. Measurements of PM10 concentrations at 10 different stations in Istanbul for the period 2004-2010 were provided by the Turkish Ministry of Environment. Daily mean PM10 concentrations exceeding the European standard of 50 µg/m3 were found to be, on average, 49 days for the Spring period, 45 days for the Winter period, and 41 days for the Fall period. DREAM model output (Nickovic et al. 2001; Perez et al. 2006) suggests that high PM10 concentrations correlate highly with mineral dust transport episodes from Saharan desert (i.e., 23% for winter and 58% for spring). In this study, we have utilized RegCM4.1 model to further investigate the Saharan dust transport in the selected episodes. During the period between March 21st and 24th, 2008, observed daily mean of PM10 concentrations reach up to 140 µg/m3 in Istanbul. Simulations conducted by RegCM4.1 provides AOD (350-640 nm model band) values ranging between 0.04 and 0.98during this episode. Central Anatolia is affected from the dust transport on 21 and 22 March 2008, with a daily mean AOD of 0.9. On 23th March 2008, the dust plume reaches the Marmara Sea and AOD increases about 1.0 over the region according to both DREAM and RegCM4.1 model outputs. On the fourth day of the episode, the dust event stops and AOD decreases to 0.5 over the region. Asymmetry parameters can be seen as 0.62 during the dust episode, while single scattering albedo is about 0.93 during the entire dust episode over Istanbul. The effect of the dust episode on the regional radiative budget over Istanbul was also estimated. Model results indicate a daily

Analizando los regímenes de violación en la intersección entre la guerra y la paz en el Perú

OpenAIRE

Boesten, Jelke

2011-01-01

Utilizando el conflicto político en el Perú (1980-2000) como estudio de caso, en este trabajo sostengo que el hecho de entender la violación como arma de guerra oculta otros regímenes de violación que tuvieron lugar durante el conflicto armado interno y que no encajan necesariamente con esta definición.Estas prácticas incluyen la violación como consumo, la violación oportunista, la violación perpetrada por vecinos o miembros de la familia, la prostitución forzada y la violación en el periodo ...

Geohydrological studies for nuclear waste isolation at the Hanford Reservation. Volume I. Executive summary

International Nuclear Information System (INIS)

Apps, J.; Doe, T.; Doty, B.

1979-08-01

A study of the hydrology of the Pasco Basin near Richland, Washington, was initiated during FY 1978 as part of a long-term study on the feasibility of nuclear waste disposal in the Columbia River Basalt underlying the Hanford Reservation. This report summarizes the hydrology field program, Pasco Basin modeling, and groundwater chemistry program. Hanford well logs are also reviewed

Actinide extraction from ICPP sodium bearing waste with 0.75 M DHDECMP/TBP in Isopar L reg-sign

International Nuclear Information System (INIS)

Herbst, R.S.; Brewer, K.N.; Garn, T.G.; Law, J.D.; Rodriguez, A.M.; Tillotson, R.T.

1996-01-01

Recent process development efforts at the Idaho Chemical Processing Plant include examination of solvent extraction technologies for actinide partitioning from sodium bearing waste (SBW) solutions. The use of 0.75 M dihexyl-N, N-diethylcarbamoylmethylphosphonate (DHDECMP or simply CMP) and 1.0 M tri-n-butyl phosphate (TBP) diluted in Isopar L reg-sign was explored for actinide removal from simulated SBW solutions. Experimental evaluations included batch contacts in radiotracer tests with simulated sodium bearing waste solution to measure the extraction and recovery efficiency of the organic solvent. The radioactive isotopes utilized for this study included Pu-238, Pu-239, Am-241, U-233, Np-239, Zr-95, Tc-99m, and Hg-203. Extraction contacts of the organic solvent with the traced SBW stimulant, strip (back-extraction) contacts of the loaded organic solvent with either a 1-hydroxyethane-1, 1-diphosphonic acid (HEDPA) in nitric acid solution or an oxalic acid in nitric acid solution, and solvent wash contacts with sodium carbonate were performed

A regência dos verbos falar, sonhar, agradecer, pensar, colaborar e protestar do português e do francês sob a ótica da linguística contrastiva

OpenAIRE

Edson José Gomes

2004-01-01

A presente pesquisa contrasta a regência verbal do Português Língua Materna (PLM) e o ?complément d?object indirect (COI)? do Francês Língua Estrangeiro (FLE) a fim de identificar o tipo de transferência, negativa ou positiva, que a primeira exerce sob a segunda. Para tal, foram escolhidos os verbos ?falar?, ?sonhar?, ?agradecer?, ?pensar? ?colaborar? e ?protestar? (?parler?, ?rêver?, ?remercier?, ?penser?, ?collaborer? e ?protester?, respectivamente). A escolha dos verbos acima deveu-se por ...

Realization of an accelerator for environmental refreshment in case of soil; Dojo no kankyo sosei no tame no kasoku no jitsugen

Energy Technology Data Exchange (ETDEWEB)

Isogai, H; Kawakami, T [Electrotechnical Laboratories, Tsukuba (Japan)

1996-10-27

Techniques have been studied to accelerate, on a commercial scale, the natural refreshment effects which synthesize useful materials, such as compost and grape and amino acids from carbon dioxide, oxidized wastes and excretions exhausted by man. The symbiotic relationship between primeval bacteria and useful bacteria for Japanese traditional foods was investigated in 3 different experimental sections which were commonly composted; the first one consisting of composted soil, the second one provided with a layer (EM layer), in which these bacteria were densely cultured, on composted soil, and the third one with a common accelerator driven only by solar energy. A total of 9 seed potatoes were planted, 3 for each section, to monitor their growth. It is quantitatively confirmed that, when cultured in the third section, they grow roughly 3 times faster than in the first one. Sweetness can be sufficiently secured by the EM effect, because of sufficiently high ground temperature in early summer and an anaerobic atmosphere kept in the system. 6 refs., 2 figs.

Exposing the impact of opp(reg)ressive policies on teacher development and on student learning

Science.gov (United States)

Rodriguez, Alberto J.

2010-12-01

This case study draws attention to Pedro's story, a Grade 6 Latino teacher who, along with other grade 4-6 teachers, participated in a three-year professional development research project. By using data analyzed from multiple ethnographic interviews with teachers and students, and by drawing from the quantitative analyzes of concept map unit tests, we illustrate how Pedro's significant professional growth and his students' learning were truncated by top-down school district policies. These policies were implemented because of the punitive nature of the No Child Left Behind Act. Simply put, this case study exposes the impact of opp(reg)ressive policies on learning, that is, policies simultaneously oppressive and regressive. The critical perspective of the project, and its emphasis on assisting teachers to make their pedagogy and curriculum more culturally and socially relevant, was informed by sociotransformative constructivism (sTc). This is a theoretical framework that affords equal importance to cross-cultural education (learning about and acting on socially/culturally relevant issues) and social constructivism (learning to critically produce and consume knowledge). We hope that this case study will provide additional insights into the slow progress we continue to make in science teacher professional development and in closing the achievement gap.

Aspectos comparativos da regência verbal em Português e Inglês para a elaboração de um dicionário bilíngue

OpenAIRE

Mendes, Raphael [UNESP

2013-01-01

Muitas vezes as gramáticas tradicionais e os dicionários existentes não são suficientes para resolver as dúvidas de estudantes e consulentes relativas a problemas linguísticos específicos. Com base nisso, propusemos um estudo de cunho contrastivo sobre uma temática pouco explorada, mas de grande relevância para a gramática e para a lexicografia: a regência verbal. Nos dicionários, esse tipo de informação gramatical é, em geral, tratado de forma imprecisa ou sequer aparece, o que pode dificult...

Searching for serial refreshing in working memory: Using response times to track the content of the focus of attention over time.

Science.gov (United States)

Vergauwe, Evie; Hardman, Kyle O; Rouder, Jeffrey N; Roemer, Emily; McAllaster, Sara; Cowan, Nelson

2016-12-01

One popular idea is that, to support the maintenance of a set of elements over brief periods of time, the focus of attention rotates among the different elements, thereby serially refreshing the content of working memory (WM). In the research reported here, probe letters were presented between to-be-remembered letters, and response times to these probes were used to infer the status of the different items in WM. If the focus of attention cycles from one item to the next, its content should be different at different points in time, and this should be reflected in a change in the response time patterns over time. Across a set of four experiments, we demonstrated a striking pattern of invariance in the response time patterns over time, suggesting either that the content of the focus of attention did not change over time or that response times cannot be used to infer the content of the focus of attention. We discuss how this pattern constrains models of WM, attention, and human information processing.

The Politics of Subnational Undemocratic Regime Reproduction in Argentina and Mexico La política de reproducción de los regímenes subnacionales no democráticos en Argentina y México

Directory of Open Access Journals (Sweden)

Agustina Giraudy

2010-01-01

Full Text Available This article studies the continued existence of subnational undemocraticregimes in Argentina and Mexico, two countries that have recently experiencednational democratization. The first part of the article offers a conceptualizationof subnational democracy and measures its territorial extension across all subnational units. The second part explores a common, albeit not systematically tested explanation about subnational undemocratic regime continuity, namely, that these regimes persist because they meet national incumbents’ strategic political needs. This claim is tested using statistical analyses to contrast patterns of spending across undemocratic subnational units during the presidencies of Menem (1989-1999, De la Rúa (2000-2001, Duhalde (2002, and Kirchner (2003-2007 in Argentina, and Fox (2000-2006 in Mexico. Contradicting conventional wisdom, the results show that presidents only reproduce a handful of subnational undemocratic regimes, as not all of them can meet presidential needs. In addition, the results reveal that the strategic calculation of presidents regarding this  reproduction is dictated by factors that have been largely overlooked by the literature. Este artículo estudia la existencia de regímenes subnacionales no-democráticos en Argentina y México, dos pa��ses que recientemente han experimentado procesos de democratización a nivel nacional. La primera parte del artículo conceptualiza y define la democracia subnacional y mide su extensión territorial en la totalidad de los distritos subnacionales. La segunda parte explora la validez de una de las explicaciones más habituales en esta área de estudio según la cual los regímenes subnacionales no-democráticos permanecen en el poder debido a que son útiles para satisfacer las necesidades políticas de los funcionarios nacionales. La validez de esta explicación se testea con análisis estadísticos que determinan los patrones de distribución territorial de

Bioabsorbable poly-L/D-lactide (96/4) scaffold arthroplasty (RegJoint™) for trapeziometacarpal osteoarthritis: a 3-year follow-up study.

Science.gov (United States)

Mattila, Simo; Ainola, Mari; Waris, Eero

2018-05-01

The poly-L/D-lactide joint scaffold (RegJoint™) has recently been associated with adverse tissue reactions and osteolysis after partial trapeziectomy for trapeziometacarpal osteoarthritis. Twenty-two of 23 patients previously operated on with this scaffold were re-examined at a mean follow-up of 3.3 years (range 36-53 months). Overall, the results showed an unacceptably high rate of adverse tissue reactions related to the degradation process of the implant, resulting in a revision procedure in three patients. At final follow-up, at which point the implant had completely degraded, there were no signs of ongoing adverse tissue reactions. There was a significant decrease in pain, increase in strength and subjective improvement in function at final follow-up compared with the pre-operative results in patients who had not undergone revision surgery. However, owing to the high incidence of adverse tissue reactions, the use of the implant has been discontinued in the treatment of trapeziometacarpal osteoarthritis. IV.

PowerGuard{reg_sign} Advanced Manufacturing; PVMaT Phase 1 Final Technical Report: June 1, 1998 to September 30, 1999

Energy Technology Data Exchange (ETDEWEB)

Marshall, M. C.; Dinwoodie, T. L.; O' Brian, C.; Botkin, J.; Ansley, J.

2000-06-14

During Phase 1 of PowerGuard{reg_sign} Advanced Manufacturing, PowerLight Corporation accomplished the following advancements: (1) Decreased system cost by 15%; (2) Increased PowerGuard tile production capacity from 5 MW/year to 8 MW/yr; (3) Established a manufacturing layout master plan for sequential integration of semi-automated and automated component workstations; (4) Defined semi-automation or automation of selected stages of the existing tile fabrication sequence, including PV module preparation, XPS processing, and coating; (5) Completed the advancement of several design improvements to the grid-tied inverter control board, including controller redesign, integrated data acquisition system (DAS), and communications for audit-worthy verification of PV system performance; (6) Conformed to NEPA, OSHA, and other federal and state regulations applicable to the proposed production process and mitigated potential for waste streams; (7) Initiated Underwriters Laboratories listings and international certifications on PowerGuard improvements; (8) Developed finance packages and integrated warranties; (9) Evaluated commercial demonstrations that incorporated the new design features and manufacturing process.

Development of internal manifold heat exchanger (IMHEX reg sign ) molten carbonate fuel cell stacks

Energy Technology Data Exchange (ETDEWEB)

Marianowski, L.G.; Ong, E.T.; Petri, R.J.; Remick, R.J.

1991-01-01

The Institute of Gas Technology (IGT) has been in the forefront of molten carbonate fuel cell (MCFC) development for over 25 years. Numerous cell designs have been tested and extensive tests have been performed on a variety of gas manifolding alternatives for cells and stacks. Based upon the results of these performance tests, IGT's development efforts started focusing on an internal gas manifolding concept. This work, initiated in 1988, is known today as the IMHEX{reg sign} concept. MCP has developed a comprehensive commercialization program loading to the sale of commercial units in 1996. MCP's role is in the manufacture of stack components, stack assembly, MCFC subsystem testing, and the design, marketing and construction of MCFC power plants. Numerous subscale (1 ft{sup 2}) stacks have been operated containing between 3 and 70 cells. These tests verified and demonstrated the viability of internal manifolding from technical (no carbonate pumping), engineering (relaxed part dimensional tolerance requirements), and operational (good gas sealing) aspects. Simplified fabrication, ease of assembly, the elimination of external manifolds and all associated clamping requirements has significantly lowered anticipated stack costs. Ongoing 1 ft{sup 2} stack testing is generating performance and endurance characteristics as a function of system specified operating conditions. Commercial-sized, full-area stacks (10 ft{sup 2}) are in the process of being assembled and will be tested in November. This paper will review the recent developments the MCFC scale-up and manufacture work of MCP, and the research and development efforts of IGT which support those efforts. 17 figs.

Development of internal manifold heat exchanger (IMHEX reg-sign) molten carbonate fuel cell stacks

International Nuclear Information System (INIS)

Marianowski, L.G.; Ong, E.T.; Petri, R.J.; Remick, R.J.

1991-01-01

The Institute of Gas Technology (IGT) has been in the forefront of molten carbonate fuel cell (MCFC) development for over 25 years. Numerous cell designs have been tested and extensive tests have been performed on a variety of gas manifolding alternatives for cells and stacks. Based upon the results of these performance tests, IGT's development efforts started focusing on an internal gas manifolding concept. This work, initiated in 1988, is known today as the IMHEX reg-sign concept. MCP has developed a comprehensive commercialization program loading to the sale of commercial units in 1996. MCP's role is in the manufacture of stack components, stack assembly, MCFC subsystem testing, and the design, marketing and construction of MCFC power plants. Numerous subscale (1 ft 2 ) stacks have been operated containing between 3 and 70 cells. These tests verified and demonstrated the viability of internal manifolding from technical (no carbonate pumping), engineering (relaxed part dimensional tolerance requirements), and operational (good gas sealing) aspects. Simplified fabrication, ease of assembly, the elimination of external manifolds and all associated clamping requirements has significantly lowered anticipated stack costs. Ongoing 1 ft 2 stack testing is generating performance and endurance characteristics as a function of system specified operating conditions. Commercial-sized, full-area stacks (10 ft 2 ) are in the process of being assembled and will be tested in November. This paper will review the recent developments the MCFC scale-up and manufacture work of MCP, and the research and development efforts of IGT which support those efforts. 17 figs

Effects of climate changes on dust aerosol over East Asia from RegCM3

Directory of Open Access Journals (Sweden)

Dong-Feng Zhang

2016-09-01

Full Text Available In order to understand impacts of global warming on dust aerosol over East Asia, a regional climate model (RegCM3 coupled with a dust model is employed to simulate the present (1991–2000, following the observed concentration of the greenhouse gases and future (2091–2100, following the A1B scenario dust aerosol. Three experiments are performed over East Asia at a horizontal resolution of 50 km, driven by the outputs from a global model of the Model for Interdisciplinary Research on Climate (MIROC3.2_hires, two without (Exp.1 for the present and Exp.2 for the future and one with (Exp.3 for the future the radiative effects of dust aerosols. Effects of climate changes on dust aerosols and the feedback of radiative effects in the future are investigated by comparing differences of Exp.2 and Exp.1, Exp.3 and Exp.2, respectively. Results show that global warming will lead to the increases of dust emissions and column burden by 2% and 14% over East Asia, characterized by the increase in December–January–February–March (DJFM and the decrease in April–May (AM. Similar variations are also seen in the projected frequencies of high dust emission events, showing an advanced active season of dust in the future. The net top-of-atmosphere (TOA radiative forcing is positive over the desert source regions and negative over downwind regions, while the surface radiative forcing is negative over the domain, which will lead to a reduction of dust emissions and column burden.

Geologic studies of the Columbia Plateau: a status report

International Nuclear Information System (INIS)

Myers, C.W.; Price, S.M.

1979-10-01

The results of recent geologic studies of the Columbia Plateau, with emphasis on work completed under the Basalt Waste Isolation Project, Rockwell Hanford Operations, are summarized in this report. Geologic studies were performed mostly during the period from 1977 to 1979. The major objective of these studies was to examine the feasibility of using deep underground tunnels mined into Columbia River basalt beneath the Hanford Site for final storage of nuclear waste. The results are presented in four chapters: Introduction; Regional Geology; Pasco Basin Geology; and Seismicity and Tectonics. Results from surface mapping and remote sensing studies in the Washington State portion of the Columbia Plateau are presented in the Regional Geology chapter. Results from surface mapping, borehole studies, and geophysical surveys in the Pasco Basin are presented in the Pasco Basin Geology chapter. Results that relate to the tectonic stability of the Pasco Basin and Columbia Plateau and discussion of findings from earthquake monitoring in the region for the past ten years are summarized in the Seismicity and Tectonics chapter. A volume of Appendices is included. This volume contains a description of study tasks, a description of the methodology used in geophysical surveys the geophysical survey results, a summary of earthquake records in eastern Washington, a description of tectonic provinces, and a preliminary description of the regional tectonic setting of the Columbia Plateau

Hydrologic studies within the Columbia Plateau, Washington: an integration of current knowledge

International Nuclear Information System (INIS)

Gephart, R.E.; Arnett, R.C.; Baca, R.G.; Leonhart, L.S.; Spane, F.A. Jr.

1979-10-01

Hydrologic studies are one of the principal research activities within the Basalt Waste Isolation Project. The objective of these studies is to provide a clear evaluation of the hydrologic systems present within the Columbia River basalt significant to the possible siting of a waste repository. This is accomplished through an intense data gathering program in addition to conducting groundwater flow and solute transport modeling under both anticipated and credible hypothetical hydrologic scenarios. The hydrology effort is centered within the Pasco Basin located in south-central Washington State, particularly that portion of the basin within the Hanford Site. Regional hydrology studies for other portions of the Columbia Plateau are being carried out to assist in understanding the surface-water and groundwater flow systems existing within the Pasco Basin. The major questions being addressed in all of the above studies focus upon important repository considerations related to groundwater flow paths, groundwater velocities, and solute concentrations and travel times. This report summarizes the data obtained and interpretations made to date regarding the hydrology of the Pasco Basin. The text of this report is divided into four chapters. Chapter I describes the purpose and scope of the hydrology program. Chapter II discusses the regional studies. Chapter III discusses the Pasco Basin hydrology, and Chapter IV gives a status report of the numerical modeling activities

Refresher

Directory of Open Access Journals (Sweden)

Editorial Board

2013-05-01

Full Text Available It has been 10 years since the Bosnian Journal of Basic Medical Sciences had emerged in PubMed as accepted by the Medline. The journal has been the voice of the Association of Basic Medical Sciences (ABMS in Bosnia and Herzegovina (B&H. We can still remember the foundation assembly of ABMS B&H with the auditorium at the Institute of Physiology at the Medical Faculty, Sarajevo, full of the most respected representatives of scientific community accepting with delight the idea to restore considerably reduced number of scientist in 1992 in the field of basic medical sciences. All members of the Academy of Sciences and Arts of Bosnia and Herzegovina who were in the country at that time, came to this gathering to provide their support in founding ABMS.The idea to establish the journal was accepted and conclusion was made to invite experts in some fields for collaboration by providing their scripts, to accept the role of reviewers, and to write editorials in relevant fields (genetics, immunology, molecular biology.At that time, nobody was aware that that Assembly was the beginning of affirmation and promotion of the journal that has, after years of regular publishing, become an international brand which web page has visited thousands of scientists from 147 countries.For all of us who have all this time been an anonymous technical support and initiators of all activities related to collecting manuscripts, ensuring independent reviews, writing editorials, and obtaining financing for 4 annual editions of the journal, all these would not have been possible without support from our academic community. We have to remember especially our deceased members of Academy Seid Hukovic, Aleksandar Nikulin, and Jela Grujic-Vasic, and current active support from Academics Muhidin Hamamdzic and Ljubomir Berberovic, and our departed Professors - Irfan Zulic, Vladimir Milicevic, Husein Susic, Branko Nikolin and Dubravka Potkonjak.Nevertheless, it should be stressed that all this journey has most frequently been excruciating for all those involved. This has been period during which for mere journal “survival”, we encountered incredible situations that we had to overcome by providing determined powerful arguments and persuasions, and with the help of many contacts and friends of the journal. At the moment when we remember all details, some of which mentioned here, we can proudly stress that younger, far and wide educated, generations are emerging. We sincerely wish that by using their knowledge and determination, they ensure publishing of their research, achieve knowledge transfer, become accessible, and affirm themselves in the world’s meticulous intellectual market.Hence, we call upon all of you to publish your best research in the journal which has achieved considerable reputation with its web page visited by respectable number of scientist from many countries. Though a small country, we have quite distinguished Diaspora that want to collaborate with their native country and that has established their place in a brutal competition within the job market.Each year, famous scientists, members of Bosnia Herzegovina American Academy of Arts and Sciences (BHAAAS from USA, come to one of the university centres in B&H. Through a direct exchange of knowledge, they help most recent scientific discoveries and breakthroughs in the world to come closer to their colleagues in the homeland. Many times our journal has made possible for these authors to publish all of their manuscripts exclusively.Editorial BoardBosnian Journal of Basic Medical Sciences 

Numerical modeling of ground-water flow systems in the vicinity of the reference repository location, Hanford Site, Washington

International Nuclear Information System (INIS)

Davis, P.; Beyeler, W.; Logsdon, M.; Coleman, N.; Brinster, K.

1989-04-01

This report documents south-central Washington State's Pasco Basin ground-water modeling studies. This work was done to support the NRC's review of hydrogeologic studies under the Department of Energy's (DOE) Basalt Waste Isolation Project. The report provides a brief overview of the geology, hydrology, and hydrochemistry of the Pasco Basin as a basis for the evaluation of previous conceptual and numerical ground-water flow models of the region. Numerical models were developed to test new conceptual models of the site and to provide a means of evaluating the Department of Energy's performance assessments and proposed hydrologic testing. Regional ground-water flow modeling of an area larger than the Pasco Basin revealed that current concepts on the existence and behavior of a hydrologic barrier west of the proposed repository location are inconsistent with available data. This modeling also demonstrated that the measured pattern of hydraulic heads cannot be produced with a model that (1) has uniform layer properties over the entire domain; (2) has zones of large conductivity associated with anticlinal structures; or (3) includes recharge from the industrial disposal ponds. Adequate representation of the measured hydraulic heads was obtained with a model that contained regions of larger hydraulic conductivity that corresponded to the presence of sedimentary interbeds. In addition, a detailed model of a region smaller than the Pasco Basin was constructed to provide the NRC staff with the ability to analyze proposed Department of Energy hydrologic tests. 62 refs., 145 figs., 18 tabs

Hydrologic bibliography of the Columbia River basalts in Washington

International Nuclear Information System (INIS)

Tanaka, H.H.; Wildrick, L.

1978-07-01

This bibliography is part of the hydrologic data compilation effort of the Columbia Plateau Hydrology Study, Rockwell Hanford Operations' Waste Isolation Program. It includes references on both surface and subsurface hydrology directly or indirectly related to the Washington State portion of the Columbia River basalts. A comprehensive, annotated bibliography of the Pasco Basin (including the Hanford site) hydrology has been prepared for Rockwell Hanford Operations under the Pasco Basin Hydrology Study. In order to avoid unnecessary duplication, no effort was made to include a complete list of bibliographic references on Hanford in this volume

The Wallula fault and tectonic framework of south-central Washington, as interpreted from magnetic and gravity anomalies

Science.gov (United States)

Blakely, Richard J.; Sherrod, Brian; Weaver, Craig S.; Wells, Ray; Rohay, Alan C.

2014-01-01

The Yakima fold and thrust belt (YFTB) in central Washington has accommodated regional, mostly north-directed, deformation of the Cascadia backarc since prior to emplacement of Miocene flood basalt of the Columbia River Basalt Group (CRBG). The YFTB consists of two structural domains. Northern folds of the YFTB strike eastward and terminate at the western margin of a 20-mGal negative gravity anomaly, the Pasco gravity low, straddling the North American continental margin. Southern folds of the YFTB strike southeastward, form part of the Olympic–Wallowa lineament (OWL), and pass south of the Pasco gravity low as the Wallula fault zone. An upper crustal model based on gravity and magnetic anomalies suggests that the Pasco gravity low is caused in part by an 8-km-deep Tertiary basin, the Pasco sub-basin, abutting the continental margin and concealed beneath CRBG. The Pasco sub-basin is crossed by north-northwest-striking magnetic anomalies caused by dikes of the 8.5 Ma Ice Harbor Member of the CRBG. At their northern end, dikes connect with the eastern terminus of the Saddle Mountains thrust of the YFTB. At their southern end, dikes are disrupted by the Wallula fault zone. The episode of NE–SW extension that promoted Ice Harbor dike injection apparently involved strike-slip displacement on the Saddle Mountains and Wallula faults. The amount of lateral shear on the OWL impacts the level of seismic hazard in the Cascadia region. Ice Harbor dikes, as mapped with aeromagnetic data, are dextrally offset by the Wallula fault zone a total of 6.9 km. Assuming that dike offsets are tectonic in origin, the Wallula fault zone has experienced an average dextral shear of 0.8 mm/y since dike emplacement 8.5 Ma, consistent with right-lateral stream offsets observed at other locations along the OWL. Southeastward, the Wallula fault transfers strain to the north-striking Hite fault, the possible location of the M 5.7 Milton-Freewater earthquake in 1936.

Hydrologic bibliography of the Columbia River basalts in Washington with selected annotations

International Nuclear Information System (INIS)

Tanaka, H.; Wildrick, L.; Pearson, B.

1979-08-01

The objective of this compilation is to present a comprehensive listing of the published, unpublished, and open file references pertaining to the surface and subsurface hydrology of the Columbia River basalts within the State of Washington and is presented in support of Rockwell's hydrologic data compilation effort for the Basalt Waste Isolation Program. A comprehensive, annotated bibliography of the Pasco Basin (including the Hanford Site) hydrology has been prepared for Rockwell as part of the Pasco Basin hydrology studies. In order to avoid unnecessary duplication, no effort was made to include a complete list of bibliographic references on Hanford in this volume

The performance of RegCM4 over the Central America and Caribbean region using different cumulus parameterizations

Science.gov (United States)

Martínez-Castro, Daniel; Vichot-Llano, Alejandro; Bezanilla-Morlot, Arnoldo; Centella-Artola, Abel; Campbell, Jayaka; Giorgi, Filippo; Viloria-Holguin, Cecilia C.

2018-06-01

A sensitivity study of the performance of the RegCM4 regional climate model driven by the ERA Interim reanalysis is conducted for the Central America and Caribbean region. A set of numerical experiments are completed using four configurations of the model, with a horizontal grid spacing of 25 km for a period of 6 years (1998-2003), using three of the convective parameterization schemes implemented in the model, the Emanuel scheme, the Grell over land-Emanuel over ocean scheme and two configurations of the Tiedtke scheme. The objective of the study is to investigate the ability of each configuration to reproduce different characteristics of the temperature, circulation and precipitation fields for the dry and rainy seasons. All schemes simulate the general temperature and precipitation patterns over land reasonably well, with relatively high correlations compared to observation datasets, though in specific regions there are positive or negative biases, greater in the rainy season. We also focus on some circulation features relevant for the region, such as the Caribbean low level jet and sea breeze circulations over islands, which are simulated by the model with varied performance across the different configurations. We find that no model configuration assessed is best performing for all the analysis criteria selected, but the Tiedtke configurations, which include the capability of tuning in particular the exchanges between cloud and environment air, provide the most balanced range of biases across variables, with no outstanding systematic bias emerging.

A PC Program to Calculate the One-Sided Lower Tolerance Limit for Total Ionizing Dose Radiation Data

Science.gov (United States)

1991-08-01

include <graphics .h> #define VEDIO OxlO #define ESC 27 1* Decelerations * FILE *pfile; FILE *outf; FILE *inf; mnt n; mnt un; float max scale...regs.h.ah=2; regs .h.dh=y; regs .h.dl=x; regs .h.bh=O; int86( VEDIO , &regs, &regs); char attribute(char blink, char back-color,char intensity, char...set lint mode) union REGS regs; regs.h.ah=O; regs h a l-mode; int86( VEDIO , &regs, &regs); void str-color (char x, char y, char *str, char blink, char

FZUImageReg: A toolbox for medical image registration and dose fusion in cervical cancer radiotherapy.

Directory of Open Access Journals (Sweden)

Qinquan Gao

Full Text Available The combination external-beam radiotherapy and high-dose-rate brachytherapy is a standard form of treatment for patients with locally advanced uterine cervical cancer. Personalized radiotherapy in cervical cancer requires efficient and accurate dose planning and assessment across these types of treatment. To achieve radiation dose assessment, accurate mapping of the dose distribution from HDR-BT onto EBRT is extremely important. However, few systems can achieve robust dose fusion and determine the accumulated dose distribution during the entire course of treatment. We have therefore developed a toolbox (FZUImageReg, which is a user-friendly dose fusion system based on hybrid image registration for radiation dose assessment in cervical cancer radiotherapy. The main part of the software consists of a collection of medical image registration algorithms and a modular design with a user-friendly interface, which allows users to quickly configure, test, monitor, and compare different registration methods for a specific application. Owing to the large deformation, the direct application of conventional state-of-the-art image registration methods is not sufficient for the accurate alignment of EBRT and HDR-BT images. To solve this problem, a multi-phase non-rigid registration method using local landmark-based free-form deformation is proposed for locally large deformation between EBRT and HDR-BT images, followed by intensity-based free-form deformation. With the transformation, the software also provides a dose mapping function according to the deformation field. The total dose distribution during the entire course of treatment can then be presented. Experimental results clearly show that the proposed system can achieve accurate registration between EBRT and HDR-BT images and provide radiation dose warping and fusion results for dose assessment in cervical cancer radiotherapy in terms of high accuracy and efficiency.

New light on R.E.G. Pichi Sermolli’s plants from the Lake Tana expedition in 1937 – an important collection from Ethiopia at the Centro Studi Erbario Tropicale (FT)

DEFF Research Database (Denmark)

Friis, Ib

2015-01-01

At the age of 24, R.E.G. Pichi Sermolli (1912–2005) travelled to Ethiopia as botanist on the Missione di Studio al Lago Tana, staying in Eritrea and Ethiopia from early January to late April 1937. The expedition was organized by the Centro Studi per l’Africa Orientale Italiana under the Reale...... Accademia d’Italia and resulted in 2649 collections of flowering plants. During the subsequent years of war, Pichi Sermolli had no time for his Ethiopian collections, but in 1947 he was able to identify them on visits to Geneva, Paris, Kew and London. Erbario Tropicale (FT) received the first set...

Natural analog study of engineered protective barriers at the Hanford Site

International Nuclear Information System (INIS)

Bjornstad, B.N.; Teel, S.S.

1993-09-01

The purpose of this study is to evaluate surficial sedimentary deposits formed in the Pasco Basin over the geologic past as analogs for engineered protective barriers. Evidence for likely changes to be expected in an engineered barrier are preserved in geologically recent deposits. Although the design life of the engineered bonier is only 1,000 years, soils and sediments of this age are uncommon in the Pasco Basin. The evidence of and probability for the following natural processes that could adversely affect the long-term stability of an engineered protective barrier reviewed in this report are deflation by wind, soil compaction, soil eluviation/illuviation, bioturbation, and cryoturbation

Trigonometry refresher

CERN Document Server

Klaf, A Albert

2005-01-01

Covers the most important aspects of plane and spherical trigonometry. Discusses special problems in navigation, surveying, elasticity, architecture, and various fields of engineering. Includes 1,738 problems, many with solutions. 1946 edition. Features 494 figures.

Important considerations for radiochromic film dosimetry with flatbed CCD scanners and EBT GAFCHROMIC[reg] film

International Nuclear Information System (INIS)

Lynch, Bart D.; Kozelka, Jakub; Ranade, Manisha K.; Li, Jonathan G.; Simon, William E.; Dempsey, James F.

2006-01-01

In this study, we present three significant artifacts that have the potential to negatively impact the accuracy and precision of film dosimetry measurements made using GAFCHROMIC[reg] EBT radiochromic film when read out with CCD flatbed scanners. Films were scanned using three commonly employed instruments: a Macbeth TD932 spot densitometer, an Epson Expression 1680 CCD array scanner, and a Microtek ScanMaker i900 CCD array scanner. For the two scanners we assessed the variation in optical density (OD) of GAFCHROMIC EBT film with scanning bed position, angular rotation of the film with respect to the scan line direction, and temperature inside the scanner due to repeated scanning. Scanning uniform radiochromic films demonstrated a distinct bowing effect in profiles in the direction of the CCD array with a nonuniformity of up to 17%. Profiles along a direction orthogonal to the CCD array demonstrated a 7% variation. A strong angular dependence was found in measurements made with the flatbed scanners; the effect could not be reproduced with the spot densitometer. An IMRT quality assurance film was scanned twice rotating the film 90 deg. between the scans. For films scanned on the Epson scanner, up to 12% variation was observed in unirradiated EBT films rotated between 0 deg. and 90 deg. , which decreased to approximately 8% for EBT films irradiated to 300 cGy. Variations of up to 80% were observed for films scanned with the Microtek scanner. The scanners were found to significantly increase the film temperature with repeated scanning. Film temperature between 18 and 33 deg. C caused OD changes of approximately 7%. Considering these effects, we recommend adherence to a strict scanning protocol that includes: maintaining the orientation of films scanned on flatbed scanners, limiting scanning to the central portion of the scanner bed, and limiting the number of consecutive scans to minimize changes in OD caused by film heating

Seasonal prediction for Southern Africa: Maximising the skill from forecast systems

CSIR Research Space (South Africa)

Landman, WA

2012-06-01

Full Text Available /system development started in early 1990s ? SAWS, UCT, UP, Wits (statistical forecast systems) ? South African Long-Lead Forecast Forum ? SARCOF started in 1997 ? consensus through discussions ? Late 1990s ? started to use AGCMs and post-processing ? At SAWS... Reg1 Reg2 Reg3 Reg4 Reg5 Reg6 Reg7 Reg8 Regions RO C ar ea s Below-Normal Near-Normal Above-Normal Operational Forecast Skill From CONSENSUS discussions Verification over 7 years of consensus forecast production New objective multi...

Regadenoson pharmacologic stress for myocardial perfusion imaging: a three-way comparison between regadenoson administered at peak exercise, during walk recovery, or no-exercise.

Science.gov (United States)

Thompson, Randall C; Patil, Harshal; Thompson, Elaine C; Thomas, Gregory S; Al-Amoodi, Mohammed; Kennedy, Kevin F; Bybee, Kevin A; Iain McGhie, A; O'Keefe, James H; Oakes, Lisa; Bateman, Timothy M

2013-04-01

Regadenoson (Reg) is being administered with increasing frequency either at peak exercise (ExPeak-Reg) or during a slow-down/walking recovery state (ExRec-Reg) rather than at rest (Rest-Reg). The aim of this study was to compare the clinical response of ExPeak-Reg, ExRec-Reg, and Rest-Reg. We compared 531 patients divided equally between Rest-Reg, ExPeak-Reg, and ExRec-Reg matched for age, sex, and BMI. The average systolic blood pressure (SBP) rise following Reg was modest, but there was considerable heterogeneity and the ExPeak-Reg group had a higher percentage of patients who had a SBP rise of 40 mm Hg or a fall of 20 mm Hg than either the ExRec-Reg or the Rest-Reg groups (≥40 mm Hg rise 6.8%, 1.7%, and 1.7%, respectively) (P < .02) (≥20 mm Hg fall 15.8%, 13.0%, and 7.3%, respectively) (P < .05). Chest discomfort, nausea, dizziness, and interfering abdominal radiotracer activity were less common in both exercise Reg groups compared to Rest-Reg (P < .05). Regadenoson injected at peak of symptom-limited exercise was generally well tolerated, but some patients had a significant rise or drop in SBP. There is no apparent advantage of administering regadenoson at peak exercise rather than during walk recovery, and the latter approach may have a greater safety margin.

Registration of six grain sorghum pollinator (R) lines

Science.gov (United States)

Six sorghum [Sorghum bicolor (L.) Moench] pollinators [KS142R (Reg. No. PI XXXX), KS143R (Reg. No. PI XXXX), KS144R (Reg.No. PI XXXX), KS145R (Reg. No. PI XXXX), KS146R (Reg. No. PI XXXX) and KS147R (Reg. No. PI XXXX) were developed from random mating using a recurrent selection followed by pedigree...

Fluorine Gauche Effect Explained by Electrostatic Polarization Instead of Hyperconjugation: An Interacting Quantum Atoms (IQA) and Relative Energy Gradient (REG) Study.

Science.gov (United States)

Thacker, Joseph C R; Popelier, Paul L A

2018-02-08

We present an interacting quantum atoms (IQA) study of the gauche effect by comparing 1,2-difluoroethane, 1,2-dichloroethane, and three conformers of 1,2,3,4,5,6-hexafluorocyclohexane. In the 1,2-difluoroethane, the gauche effect is observed in that the gauche conformation is more stable than the anti, whereas in 1,2-dichloroethane the opposite is true. The analysis performed here is exhaustive and unbiased thanks to using the recently introduced relative energy gradient (REG) method [ Thacker , J. C. R. ; Popelier , P. L. A. Theor. Chem. Acc . 2017 , 136 , 86 ], as implemented in the in-house program ANANKE. We challenge the common explanation that hyperconjugation is responsible for the gauche stability in 1,2-difluoroethane and instead present electrostatics as the cause of gauche stability. Our explanation of the gauche effect is also is seen in other molecules displaying local gauche conformations, such as the recently synthesized "all-cis" hexafluorocyclohexane and its conformers where all the fluorine atoms are in the equatorial positions. Using our extension of the traditional IQA methodology that allows for the partitioning of electrostatic terms into polarization and charge transfer, we propose that the cause of gauche stability is 1,3 C···F electrostatic polarization interactions. In other words, if a number of fluorine atoms are aligned, then the stability due to polarization of nearby carbon atoms is increased.

2011 SWFWMD Topographic Lidar: Pasco County

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — SWFWMD regularly uses digital topographic information to support regulatory, land management and acquisition, planning, engineering and habitat restoration projects....

Trait anxiety and impaired control of reflective attention in working memory.

Science.gov (United States)

Hoshino, Takatoshi; Tanno, Yoshihiko

2016-01-01

The present study investigated whether the control of reflective attention in working memory (WM) is impaired in high trait anxiety individuals. We focused on the consequences of refreshing-a simple reflective process of thinking briefly about a just-activated representation in mind-on the subsequent processing of verbal stimuli. Participants performed a selective refreshing task, in which they initially refreshed or read one word from a three-word set, and then refreshed a non-selected item from the initial phrase or read aloud a new word. High trait anxiety individuals exhibited greater latencies when refreshing a word after experiencing the refreshing of a word from the same list of semantic associates. The same pattern was observed for reading a new word after prior refreshing. These findings suggest that high trait anxiety individuals have difficulty resolving interference from active distractors when directing reflective attention towards contents in WM or processing a visually presented word.

The residual and direct effects of reduced-risk and conventional miticides on twospotted spider mites, Tetranychus urticae (Acari: Tetranychidae) and predatory mites (Acari: Phytoseiidae)

International Nuclear Information System (INIS)

Liburd, O.E.; White, J.C.; Rhodes, E.M.; Browdy, A.A.

2007-01-01

The residual effects of several reduced-risk and conventional miticides were evaluated in strawberries (Fragaria × ananassa Duchesne) on the twospotted spider mite (TSSM), Tetranychus urticae Koch (Acari: Tetranychidae) and on 2 predatory mites, Neoseiulus californicus McGregor and Phytoseiulus persimilis Athias-Henriot (Acari: Phytoseiidae). Experiments were conducted in the laboratory and greenhouse. The greenhouse experiments also tested the direct effects of the miticides on TSSM. The efficacy of conventional and reduced-risk miticides was evaluated on strawberry leaf discs and on whole plants for control of TSSM. Furthermore, the residual effects of these miticides were evaluated on whole strawberry plants against selective predatory mites. For TSSM, 5 treatments were evaluated: a conventional miticide; fenbutatin-oxide (Vendex[reg]) and 3 reduced-risk miticides; binfenazate (Acramite 50WP[reg]), activated garlic extract (Repel[reg]), sesame seed and castor oil (Wipeout[reg]), and a water-treated control. For predatory mites, the residual effects of only Acramite[reg] and Vendex[reg] were evaluated. Acramite[reg] was the most effective acaricide in reducing TSSM populations in both the laboratory and greenhouse experiments. Vendex[reg] and Wipeout[reg] were also effective in the laboratory, but did not cause significant reduction of TSSM in the greenhouse. Repel[reg] was the least effective of the 4 pesticides evaluated. Neither Acramite[reg] nor Vendex[reg] had a significant effect on either predatory mite species. However, there appeared to be more predatory mites on the Vendex[reg]-treated plants than on the Acramite[reg]-treated plants. There were significantly more predatory mites of both species on the cue plants, which were inoculated with TSSM versus the non-cue plants, which were not inoculated. (author) [es

Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK rats.

Directory of Open Access Journals (Sweden)

Sophie Calderari

Full Text Available Regenerating (REG proteins are associated with islet development, β-cell damage, diabetes and pancreatitis. Particularly, REG-1 and REG-3-beta are involved in cell growth/survival and/or inflammation and the Reg1 promoter contains interleukin-6 (IL-6-responsive elements. We showed by transcriptome analysis that islets of Goto-Kakizaki (GK rats, a model of spontaneous type 2 diabetes, overexpress Reg1, 3α, 3β and 3γ, vs Wistar islets. Goto-Kakizaki rat islets also exhibit increased cytokine/chemokine expression/release, particularly IL-6. Here we analyzed Reg1 and Reg3β expression and REG-1 immuno-localization in the GK rat pancreas in relationship with inflammation. Isolated pancreatic islets and acinar tissue from male adult Wistar and diabetic GK rats were used for quantitative RT-PCR analysis. REG-1 immunohistochemistry was performed on paraffin sections with a monoclonal anti-rat REG-1 antibody. Islet cytokine/chemokine release was measured after 48 h-culture. Islet macrophage-positive area was quantified on cryostat sections using anti-CD68 and major histocompatibility complex (MHC class II antibodies. Pancreatic exocrine-to-endocrine Reg1 and Reg3β mRNA ratios were markedly increased in Wistar vs GK rats. Conversely, both genes were upregulated in isolated GK rat islets. These findings were unexpected, because Reg genes are expressed in the pancreatic acinar tissue. However, we observed REG-1 protein labeling in acinar peri-ductal tissue close to islets and around large, often disorganized, GK rat islets, which may retain acinar cells due to their irregular shape. These large islets also showed peri-islet macrophage infiltration and increased release of various cytokines/chemokines, particularly IL-6. Thus, IL-6 might potentially trigger acinar REG-1 expression and secretion in the vicinity of large diabetic GK rat islets. This increased acinar REG-1 expression might reflect an adaptive though unsuccessful response to deleterious

O gênero Strangalia Audinet-Serville no Norte e Centro-Oeste do Brasil (Coleoptera, Cerambycidae, Lepturinae The genus Strangalia Audinet-Serville in northern and central Brazil (Coleoptera, Cerambycidae, Lepturinae

Directory of Open Access Journals (Sweden)

Marcela L. Monné

2005-06-01

Full Text Available As espécies do gênero Strangalia Audinet-Serville do Norte e Centro-Oeste do Brasil são revistas. Strangalia xanthomelaena sp. nov. é descrita de Rondônia e Mato Grosso, Brasil. Dois novos sinônimos são propostos: Ophistomis irene Gounelle, 1911 = Euryptera albicollis Pascoe, 1860; O. paraensis Bates, 1870 = O. bivittatus Bates, 1870. São fornecidas ilustrações e chave para identificação das espécies.The species of the genus Strangalia from northern and central Brazil are revised. Strangalia xanthomelaena sp. nov. is described from Rondônia and Mato Grosso, Brazil. Two new synonyms are proposed: Ophistomis irene Gounelle, 1911 = Euryptera albicollis Pascoe, 1860; O. paraensis Bates, 1870 = O. bivittatus Bates, 1870. Illustrations and key for identification are provided.

Dios, Patria, Autoridad: la Iglesia Católica y la fascistización de los regímenes ibéricos, 1933-1945

Directory of Open Access Journals (Sweden)

Manuel Loff

2013-12-01

Full Text Available La crisis de los sistemas liberales ibéricos en la Europa de entreguerras es especialmente interesante por el papel específico que ocupa en ella el componente católico de laidentidad y de las coaliciones que sostuvieron los dos regímenes autoritarios. El catolicismo político tuvo un papel muy relevante en el proceso de modernización de las derechas españolas y portuguesas de la primera posguerra. Salazar y Franco presentaron los regímenes que ellosmismos construyeron y sobre los que gobernaron como siendo intrínsicamente católicos, y los católicos fueron actoresprincipales de las coaliciones políticas y sociales que sostuvieron ambos dictadores. En su lucha contra la Primera República Portuguesa (1910-26 y la Segunda República Española (1931-39, las fuerzas políticas conservadoras y de extrema derecha concedieron un papel estratégico a los católicos politicamente organizados en lo que se refiere a la movilización de las masas y en la constitución de un amplia coalición que pudiese crear una alternativa sólida a la democracia liberal y a un movimento obrero cada día más fuerte. En los años centrales de la «Era del Fascismo», las derechas católicas ibéricas y la jerarquía de la Iglesia sancionaron un giro muy notorio hacia una lectura crecientemente fascistizada del contexto político europeo posterior a la Revolución Soviética.The crisis of the Iberian liberal systems in inter-war Europe is especially interesting to study because of the specific role ofthe Catholic component of both the sustaining political coalition and the identity of these two of the European 20th century authoritarian regimes. Political Catholicism was a major actor in the modernisation process of Spanish and Portuguese post-World War I rightwing movements. Salazar and Franco presented the regimes they built up and ruled upon as being intrinsically catholic, and Catholics were major partners in the political and

Programa para el cálculo de los regímenes de operación de la red soterrada

Directory of Open Access Journals (Sweden)

Manuel Barroso Baeza

2011-03-01

Full Text Available Este trabajo tiene como objetivo el desarrollo de software para el análisis de los regímenes de trabajo normalesde la red soterrada; específicamente abarca el desarrollo y adecuación de algoritmos para flujo de carga,elaborando el producto informático propuesto empleando las técnicas de la programación visual. El programaobtenido permite analizar estudios completos del comportamiento de la red soterrada, nunca antes posible,pues se carecía de la herramienta adecuada para realizar tales estudios, o bien por falta de capacidadsuficiente en cuanto a memoria requerida para modelar la red completa , lo cual sucedió en las décadasanteriores o porque los programas que existían entonces eran desarrollados para la transmisión.  This work has as objectives the software development for the analysis of the normal load flow of the undergroundsecondary network, specifically sandal the development and adaptation of algorithms for load flow, elaborating theproposed computer product using the techniques of the visual programming. The obtained program allows toanalyze complete studies of the net behavior it was never before possible, because you lacked the appropriatetool to carry out such studies, or for lack of enough capacity as for memory required to model the complete net,that which happened in the previous decades or because the programs that existed then were developed for thetransmission. As a result final of this project a software will be reached that using a base data common to othertechnical studies, facilitate to make any of the mentioned analysis, responding to the particularities of the undergroundsecondary network.

The use of HANDIDET reg-sign non-electric detonator assemblies to reduce blast-induced overpressure at AECL's Underground Research Laboratory

International Nuclear Information System (INIS)

Onagi, D.P.; Keith, S.G.; Kuzyk, G.W.

1996-01-01

A number of aspects of the Canadian concept for nuclear fuel waste disposal are being assessed by Atomic Energy of Canada Limited (AECL) in a series of experiments at its Underground Research Laboratory (URL) near Lac du Bonnet, Manitoba, Canada. One of the major objectives of the work being carried out at the URL is to develop and evaluate the methods and technology to ensure safe, permanent disposal of Canada's nuclear fuel waste. In 1994, AECL excavated access tunnels and a laboratory room for the Quarried Block Fracture Migration Experiment (QBFME) at the 240 Level of the URL. This facility will be used to study the transport of radionuclides in natural fractures in quarried blocks of granite under in-situ groundwater conditions. The experiment is being carried out under a cooperative agreement with the Japan Atomic Energy Research Institute. The excavation of the QBFME access tunnels and laboratory was carried out using controlled blasting techniques that minimized blast-induced overpressure which could have damaged or interrupted other ongoing experiments in the vicinity. The majority of the blasts used conventional long delay non-electric detonators but a number of blasts were carried out using HANDIDET 250/6000 non-electric long delay detonator assemblies and HTD reg-sign non-electric short delay trunkline detonator assemblies. The tunnel and laboratory excavation was monitored to determine the levels of blast-induced overpressure. This paper describes the blasting and monitoring results of the blasts using HANDIDET non-electric detonator assemblies and the effectiveness of these detonators in reducing blast-induced overpressure

Assessment of two versions of regional climate model in simulating the Indian Summer Monsoon over South Asia CORDEX domain

Science.gov (United States)

Pattnayak, K. C.; Panda, S. K.; Saraswat, Vaishali; Dash, S. K.

2018-04-01

This study assess the performance of two versions of Regional Climate Model (RegCM) in simulating the Indian summer monsoon over South Asia for the period 1998 to 2003 with an aim of conducting future climate change simulations. Two sets of experiments were carried out with two different versions of RegCM (viz. RegCM4.2 and RegCM4.3) with the lateral boundary forcings provided from European Center for Medium Range Weather Forecast Reanalysis (ERA-interim) at 50 km horizontal resolution. The major updates in RegCM4.3 in comparison to the older version RegCM4.2 are the inclusion of measured solar irradiance in place of hardcoded solar constant and additional layers in the stratosphere. The analysis shows that the Indian summer monsoon rainfall, moisture flux and surface net downward shortwave flux are better represented in RegCM4.3 than that in the RegCM4.2 simulations. Excessive moisture flux in the RegCM4.2 simulation over the northern Arabian Sea and Peninsular India resulted in an overestimation of rainfall over the Western Ghats, Peninsular region as a result of which the all India rainfall has been overestimated. RegCM4.3 has performed well over India as a whole as well as its four rainfall homogenous zones in reproducing the mean monsoon rainfall and inter-annual variation of rainfall. Further, the monsoon onset, low-level Somali Jet and the upper level tropical easterly jet are better represented in the RegCM4.3 than RegCM4.2. Thus, RegCM4.3 has performed better in simulating the mean summer monsoon circulation over the South Asia. Hence, RegCM4.3 may be used to study the future climate change over the South Asia.

CPR: Adult

Medline Plus

Full Text Available Refresher Center Home FIRST AID, CPR and AED LIFEGUARDING Refresher Putting It All Together: CPR—Adult (2:03) Refresher videos only utilize this player QUICK LINKS Home RedCross.org Purchase Course Materials Shop Our Store ...

CPR: Infant

Medline Plus

Full Text Available Refresher Center Home FIRST AID, CPR and AED LIFEGUARDING Refresher Putting It All Together: CPR—Infant (1:52) Refresher videos only utilize this player QUICK LINKS Home RedCross.org Purchase Course Materials Shop Our Store ...

The Rajahmundry Traps, Andhra Pradesh: Evaluation of their ...

Indian Academy of Sciences (India)

R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

consisting of unfossiliferous yellow calcareous shale. (Pascoe 1964). For the east .... allowing the evolved gas to be pumped away. Ages are reported relative to ..... extraction work and sources of air argon contamination;. Can. J. Earth Sci.

76 FR 68325 - Changes in Flood Elevation Determinations

Science.gov (United States)

2011-11-04

..., Orlando, FL 32801. Pasco (FEMA Docket No.: B- Unincorporated areas May 6, 2011; May 13, The Honorable Ann... September 21, 2010 480131 1205). 0342P). October 7, 2010; Terrell, Mayor, City of The Allen American. Allen...

A Prototype Regional GSI-based EnKF-Variational Hybrid Data Assimilation System for the Rapid Refresh Forecasting System: Dual-Resolution Implementation and Testing Results

Science.gov (United States)

Pan, Yujie; Xue, Ming; Zhu, Kefeng; Wang, Mingjun

2018-05-01

A dual-resolution (DR) version of a regional ensemble Kalman filter (EnKF)-3D ensemble variational (3DEnVar) coupled hybrid data assimilation system is implemented as a prototype for the operational Rapid Refresh forecasting system. The DR 3DEnVar system combines a high-resolution (HR) deterministic background forecast with lower-resolution (LR) EnKF ensemble perturbations used for flow-dependent background error covariance to produce a HR analysis. The computational cost is substantially reduced by running the ensemble forecasts and EnKF analyses at LR. The DR 3DEnVar system is tested with 3-h cycles over a 9-day period using a 40/˜13-km grid spacing combination. The HR forecasts from the DR hybrid analyses are compared with forecasts launched from HR Gridpoint Statistical Interpolation (GSI) 3D variational (3DVar) analyses, and single LR hybrid analyses interpolated to the HR grid. With the DR 3DEnVar system, a 90% weight for the ensemble covariance yields the lowest forecast errors and the DR hybrid system clearly outperforms the HR GSI 3DVar. Humidity and wind forecasts are also better than those launched from interpolated LR hybrid analyses, but the temperature forecasts are slightly worse. The humidity forecasts are improved most. For precipitation forecasts, the DR 3DEnVar always outperforms HR GSI 3DVar. It also outperforms the LR 3DEnVar, except for the initial forecast period and lower thresholds.

Resonance – Journal of Science Education | News

Indian Academy of Sciences (India)

Science Academies' Refresher Course in Statistical Physics · More Details Fulltext PDF. pp 197-197 Information and Announcements. Science Academies' Refresher Course on Modern Biiotechnology: Concepts and Practice · More Details Fulltext PDF. pp 198-198 Information and Announcements. Forty Ninth Refresher ...

Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy.

Science.gov (United States)

Sander, Frida Ewald; Nilsson, Malin; Rydström, Anna; Aurelius, Johan; Riise, Rebecca E; Movitz, Charlotta; Bernson, Elin; Kiffin, Roberta; Ståhlberg, Anders; Brune, Mats; Foà, Robin; Hellstrand, Kristoffer; Thorén, Fredrik B; Martner, Anna

2017-11-01

Regulatory T cells (T regs ) have been proposed to dampen functions of anti-neoplastic immune cells and thus promote cancer progression. In a phase IV trial (Re:Mission Trial, NCT01347996, http://www.clinicaltrials.gov ) 84 patients (age 18-79) with acute myeloid leukemia (AML) in first complete remission (CR) received ten consecutive 3-week cycles of immunotherapy with histamine dihydrochloride (HDC) and low-dose interleukin-2 (IL-2) to prevent relapse of leukemia in the post-consolidation phase. This study aimed at defining the features, function and dynamics of Foxp3 + CD25 high CD4 + T regs during immunotherapy and to determine the potential impact of T regs on relapse risk and survival. We observed a pronounced increase in T reg counts in peripheral blood during initial cycles of HDC/IL-2. The accumulating T regs resembled thymic-derived natural T regs (nT regs ), showed augmented expression of CTLA-4 and suppressed the cell cycle proliferation of conventional T cells ex vivo. Relapse of AML was not prognosticated by T reg counts at onset of treatment or after the first cycle of immunotherapy. However, the magnitude of T reg induction was diminished in subsequent treatment cycles. Exploratory analyses implied that a reduced expansion of T regs in later treatment cycles and a short T reg telomere length were significantly associated with a favorable clinical outcome. Our results suggest that immunotherapy with HDC/IL-2 in AML entails induction of immunosuppressive T regs that may be targeted for improved anti-leukemic efficiency.

Post-biological control invasion trajectory for Melaleuca quinquenervia in a seasonally inundated wetland

Science.gov (United States)

Although the exotic invasive tree Melaleuca quinquenervia has invaded and dominated South Florida wetlands since its introduction in 1886, its formerly unfettered seed production is now constrained by intentionally introduced herbivores, especially Oxyops vitiosa Pascoe (Coleoptera: Curculionidae). ...

75 FR 76282 - Domestic Shipping Services Pricing and Mailing Standards Changes

Science.gov (United States)

2010-12-08

... United States Postal Service, Domestic Mail Manual (DMM[reg]), to reflect changes to prices and mailing standards for the following Shipping Services: Express Mail[reg], Priority Mail[reg], Parcel Select[reg... following changes to Mailing Standards of the United States Postal Service, Domestic Mail Manual (DMM...

Phylogeny of the Gondwanan beetle family Ulodidae (Tenebrionoidea).

Science.gov (United States)

Leschen, Richard A B; Escalona, Hermes E; Elgueta, Mario

2016-07-18

Ulodidae is a small family of saproxylic and fungus feeding beetles restricted to New Zealand, Australia, Chile and New Caledonia. The phylogeny of this family is presented for the first time, based on a cladistic analysis of 53 adult characters from 16 ulodid genera, rooted with Parahelops Waterhouse (Promecheilidae). The topology shows Arthopus Sharp at the base of the tree and confirms the placement of Meryx Latreille as a member of Ulodidae and closely related to the Chilean genus Trachyderas Philippi & Philippi. The extinct New Zealand genus Waitomophylax Leschen & Rhode was placed among a clade consisting of Brouniphylax Strand, Exohadrus Broun, and Pteroderes Germain. Two new genera and two new species are described: Ulobostrichus gen. n. (type species: Ulobostrichus monteithi sp. n.) and Ulocyphaleus gen. n. (type species: Cyphaleus valdivianus Philippi & Philippi, 1864, now U. valdivianus (Philippi & Philippi) n. comb.; U. laetus sp. n.). Dipsaconia pyritosa Pascoe is designated as the type species of Dipsaconia Pascoe and a lectotype was designated for C. valdivianus. A fully illustrated key to the genera and a checklist of the 16 genera and 42 species is included. Based on the phylogeny, the following characters are derived in the family: tuberculate body surface and the presence of scales and /or encrustations. The presence of pore-fields in the abdominal cuticle has evolved at least three times in Meryx Latreille (Australia), Syrphetodes Pascoe (New Zealand) and Trachyderastes Kaszab (New Caledonia).

Testing cosmology with galaxy clusters

DEFF Research Database (Denmark)

Rapetti Serra, David Angelo

2011-01-01

PASCOS 2011 will be held in Cambridge UK. The conference will be hosted by the Centre for Theoretical Cosmology (DAMTP) at the Mathematical Sciences site in the University of Cambridge. The aim of the conference is to explore and develop synergies between particle physics, string theory and cosmo......PASCOS 2011 will be held in Cambridge UK. The conference will be hosted by the Centre for Theoretical Cosmology (DAMTP) at the Mathematical Sciences site in the University of Cambridge. The aim of the conference is to explore and develop synergies between particle physics, string theory...... and cosmology. There will be an emphasis on timely interdisciplinary topics: • critical tests of inflationary cosmology • advances in fundamental cosmology • applications of string theory (AdS/CMT) • particle and string phenomenology • new experimental particle physics results • and cosmological probes...

The use of HANDIDET{reg_sign} non-electric detonator assemblies to reduce blast-induced overpressure at AECL`s Underground Research Laboratory

Energy Technology Data Exchange (ETDEWEB)

Onagi, D.P.; Keith, S.G.; Kuzyk, G.W. [AECL, Pinawa, Manitoba (Canada). Underground Research Lab.; Proudfoot, D.F. [ICI Explosives Canada, North Delta, British Columbia (Canada)

1996-12-01

A number of aspects of the Canadian concept for nuclear fuel waste disposal are being assessed by Atomic Energy of Canada Limited (AECL) in a series of experiments at its Underground Research Laboratory (URL) near Lac du Bonnet, Manitoba, Canada. One of the major objectives of the work being carried out at the URL is to develop and evaluate the methods and technology to ensure safe, permanent disposal of Canada`s nuclear fuel waste. In 1994, AECL excavated access tunnels and a laboratory room for the Quarried Block Fracture Migration Experiment (QBFME) at the 240 Level of the URL. This facility will be used to study the transport of radionuclides in natural fractures in quarried blocks of granite under in-situ groundwater conditions. The experiment is being carried out under a cooperative agreement with the Japan Atomic Energy Research Institute. The excavation of the QBFME access tunnels and laboratory was carried out using controlled blasting techniques that minimized blast-induced overpressure which could have damaged or interrupted other ongoing experiments in the vicinity. The majority of the blasts used conventional long delay non-electric detonators but a number of blasts were carried out using HANDIDET 250/6000 non-electric long delay detonator assemblies and HTD{reg_sign} non-electric short delay trunkline detonator assemblies. The tunnel and laboratory excavation was monitored to determine the levels of blast-induced overpressure. This paper describes the blasting and monitoring results of the blasts using HANDIDET non-electric detonator assemblies and the effectiveness of these detonators in reducing blast-induced overpressure.

In vivo expansion of naïve CD4+ CD25(high FOXP3+ regulatory T cells in patients with colorectal carcinoma after IL-2 administration.

Directory of Open Access Journals (Sweden)

Marc Beyer

Full Text Available Regulatory T cells (T(reg cells are increased in context of malignancies and their expansion can be correlated with higher disease burden and decreased survival. Initially, interleukin 2 (IL-2 has been used as T-cell growth factor in clinical vaccination trials. In murine models, however, a role of IL-2 in development, differentiation, homeostasis, and function of T(reg cells was established. In IL-2 treated cancer patients a further T(reg-cell expansion was described, yet, the mechanism of expansion is still elusive. Here we report that functional T(reg cells of a naïve phenotype--as determined by CCR7 and CD45RA expression--are significantly expanded in colorectal cancer patients. Treatment of 15 UICC stage IV colorectal cancer patients with IL-2 in a phase I/II peptide vaccination trial further enlarges the already increased naïve T(reg-cell pool. Higher frequencies of T-cell receptor excision circles in naïve T(reg cells indicate IL-2 dependent thymic generation of naïve T(reg cells as a mechanism leading to increased frequencies of T(reg cells post IL-2 treatment in cancer patients. This finding could be confirmed in naïve murine T(reg cells after IL-2 administration. These results point to a more complex regulation of T(reg cells in context of IL-2 administration. Future strategies therefore might aim at combining IL-2 therapy with novel strategies to circumvent expansion and differentiation of naïve T(reg cells.

Registration of four post-flowering drought tolerant grain sorghum lines with early season cold tolerance

Science.gov (United States)

Four sorghum (Sorghum bicolor L.) germplasm lines— PSLS-SGCTB01 (Reg. No.), PSLS-SGCTR02 (Reg. No.), PSLS-SGCTB03 (Reg. No.) and PSLS-SGCTB04 (Reg. No.) — were developed by the USDA-ARS in Lubbock TX, in 2017. The primary purpose for the release of these lines is to provide an alternative germplasm ...

Simulation of bulk aerosol direct radiative effects and its climatic feedbacks in South Africa using RegCM4

Science.gov (United States)

Tesfaye, M.; Botai, J.; Sivakumar, V.; Mengistu Tsidu, G.; Rautenbach, C. J. deW.; Moja, Shadung J.

2016-05-01

In this study, 12 year runs of the Regional Climate Model (RegCM4) have been used to analyze the bulk aerosol radiative effects and its climatic feedbacks in South Africa. Due to the geographical locations where the aerosol potential source regions are situated and the regional dynamics, the South African aerosol spatial-distribution has a unique feature. Across the west and southwest areas, desert dust particles are dominant. However, sulfate and carbonaceous aerosols are primarily distributed over the east and northern regions of the country. Analysis of the Radiative Effects (RE) shows that in South Africa the bulk aerosols play a role in reducing the net radiation absorbed by the surface via enhancing the net radiative heating in the atmosphere. Hence, across all seasons, the bulk aerosol-radiation-climate interaction induced statistically significant positive feedback on the net atmospheric heating rate. Over the western and central parts of South Africa, the overall radiative feedbacks of bulk aerosol predominantly induces statistically significant Cloud Cover (CC) enhancements. Whereas, over the east and southeast coastal areas, it induces minimum reductions in CC. The CC enhancement and RE of aerosols jointly induce radiative cooling at the surface which in turn results in the reduction of Surface Temperature (ST: up to -1 K) and Surface Sensible Heat Flux (SSHF: up to -24 W/m2). The ST and SSHF decreases cause a weakening of the convectively driven turbulences and surface buoyancy fluxes which lead to the reduction of the boundary layer height, surface pressure enhancement and dynamical changes. Throughout the year, the maximum values of direct and semi-direct effects of bulk aerosol were found in areas of South Africa which are dominated by desert dust particles. This signals the need for a strategic regional plan on how to reduce the dust production and monitoring of the dust dispersion as well as it initiate the need of further research on different

Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).

Science.gov (United States)

Chan, Derek V; Somani, Ally-Khan; Young, Andrew B; Massari, Jessica V; Ohtola, Jennifer; Sugiyama, Hideaki; Garaczi, Edina; Babineau, Denise; Cooper, Kevin D; McCormick, Thomas S

2011-05-26

Elevated numbers of regulatory T cells (T(regs)) have been implicated in certain cancers. Depletion of T(regs) has been shown to increase anti-tumor immunity. T(regs) also play a critical role in the suppression of autoimmune responses. The study of T(regs) has been hampered by a lack of adequate surface markers. Leucine Rich Repeat Containing 32 (LRRC32), also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated T(regs). However, there is limited information regarding the processing of LRRC32 or the regulatory phenotype and functional activity of T(regs) expressing LRRC32. Using naturally-occurring freshly isolated T(regs), we demonstrate that low levels of LRRC32 are present intracellularly prior to activation and that freshly isolated LRRC32+ T(regs) are distinct from LRRC32- T(regs) with respect to the expression of surface CD62L. Using LRRC32 transfectants of HEK cells, we demonstrate that the N-terminus of LRRC32 is cleaved prior to expression of the protein at the cell surface. Furthermore, we demonstrate using a construct containing a deleted putative signal peptide region that the presence of a signal peptide region is critical to cell surface expression of LRRC32. Finally, mixed lymphocyte assays demonstrate that LRRC32+ T(regs) are more potent suppressors than LRRC32- T(regs). A cleaved signal peptide site in LRRC32 is necessary for surface localization of native LRRC32 following activation of naturally-occurring freshly-isolated regulatory T cells. LRRC32 expression appears to alter the surface expression of activation markers of T cells such as CD62L. LRRC32 surface expression may be useful as a marker that selects for more potent T(reg) populations. In summary, understanding the processing and expression of LRRC32 may provide insight into the mechanism of action of T(regs) and the refinement of immunotherapeutic strategies aimed at targeting these cells.

The impact of cognitive load on delayed recall.

Science.gov (United States)

Camos, Valérie; Portrat, Sophie

2015-08-01

Recent studies have suggested that long-term retention of items studied in a working memory span task depends on the refreshing of memory items-more specifically, on the number of refreshing opportunities. However, it was previously shown that refreshing depends on the cognitive load of the concurrent task introduced in the working memory span task. Thus, cognitive load should determine the long-term retention of items assessed in a delayed-recall test if such retention relies on refreshing. In two experiments, while the amount of refreshing opportunities remained constant, we varied the cognitive load of the concurrent task by either introducing tasks differing in their attentional demands or varying the pace of the concurrent task. To verify that this effect was related to refreshing and not to any maintenance mechanism, we also manipulated the availability of subvocal rehearsal. Replicating previous results, increasing cognitive load reduced immediate recall. This increase also had a detrimental effect on delayed recall. Conversely, the addition of concurrent articulation reduced immediate but not delayed recall. This study shows that both working and episodic memory traces depend on the cognitive load of the concurrent task, whereas the use of rehearsal affects only working memory performance. These findings add further evidence of the dissociation between subvocal rehearsal and attentional refreshing.

Registration of cytoplasmic male-sterile oilseed sunflower genetic stocks CMS GIG2 and CMS GIG2-RV, and fertility restoration lines RF GIG2-MAX 1631 and RF GIG2-MAX 1631-RV

Science.gov (United States)

Two cytoplasmic male-sterile (CMS) oilseed sunflower (Helianthus annuus L.) genetic stocks, CMS GIG2 (Reg. No. xxx, PI xxxx), and CMS GIG2-RV (Reg. No. xxx, PI xxxx), and corresponding fertility restoration lines RF GIG2-MAX 1631 (Reg. No. xxx, PI xxxx) and RF GIG2-MAX 1631-RV (Reg. No. xxx, PI xxx...

MAR binding protein SMAR1 favors IL-10 mediated regulatory T cell function in acute colitis

International Nuclear Information System (INIS)

Mirlekar, Bhalchandra; Patil, Sachin; Bopanna, Ramanamurthy; Chattopadhyay, Samit

2015-01-01

T reg cells are not only crucial for controlling immune responses to autoantigens but also prevent those directed towards commensal pathogens. Control of effector immune responses by T reg cells depend on their capacity to accumulate at inflammatory site and accordingly accommodate to inflammatory environment. Till date, the factors associated with maintaining these aspects of T reg phenotype is not understood properly. Here we have shown that a known nuclear matrix binding protein SMAR1 is selectively expressed more in colonic T reg cells and is required for their ability to accumulate at inflammatory site and to sustain high levels of Foxp3 and IL-10 expression during acute colitis. Elimination of anti-inflammatory subsets revealed a protective role for IL-10 producing T reg cells in SMAR1 −/− mice. Moreover, a combined action of Foxp3 and SMAR1 restricts effector cytokine production and enhance the production of IL-10 by colonic T reg cells that controls acute colitis. This data highlights a critical role of SMAR1 in maintaining T reg physiology during inflammatory disorders. - Highlights: • SMAR1 is essential to sustain high level of Foxp3 and IL-10 in T reg cells. • SMAR1 −/− T reg cells produce pro-inflammatory cytokine IL-17 leads to inflammation. • IL-10 administration can control the inflammation in SMAR1 −/− mice. • Both Foxp3 and SMAR1 maintain T reg phenotype that controls colitis

A review of the genus Potemnemus Thomson, 1864 (Coleoptera: Cerambycidae) with description of a new species from Papua New Guinea.

Science.gov (United States)

Wallin, Henrik; Kvamme, Torstein

2015-11-13

All preserved type specimens and type series of the genus Potemnemus Thomson, 1864 from museum collections have been examined. The presented taxonomic study is based on examination of morphological characters as well as studies of the genitalia. The genitalia are described for the first time. The type of P. scabrosus Olivier, 1790 is lost, and the original drawing has been designated as a lectotype. The monospecific genus Parapotemnemus Breuning, 1971 nov. syn. is considered to be a junior synonym of Potemnemus Thomson, 1864 based on similarities in both external and male genitalia characters. Potemnemus wheatcrofti (Breuning, 1971) nov. comb. thus becomes a new combination. The holotype of P. wheatcrofti nov. comb. is lost, and a paratype ♂ has been designated as a neotype. Potemnemus nylanderi nov. sp. is described from the eastern parts of Papua New Guinea. The following new synonyms within the genus Potemnemus have been introduced: P. hispidus Gressitt, 1952 nov. syn. is a junior synonym of P. sepicanus Kriesche, 1923, P. detzneri Kriesche, 1923 nov. syn. is a junior synonym of P. trimaculatus Lea, 1918, and P. loriai Breuning, 1956 nov. syn. and P. triturberculatus Breuning, 1942 nov. syn. are both junior synonyms of P. scabrosus (Olivier, 1790). As a result of the present study the following species have been resurrected to species level: Potemnemus trimaculatus Lea, 1918 sp. res., P. wolfi Berchmans, 1925 sp. res., and P. thomsoni Lansberge, 1880 sp. res. The genus Periaptodes Pascoe, 1866 gen. res. has been resurrected as a valid genus based on differences in both external and male genitalia characters, and re-descriptions of the genera Potemnemus and Periaptodes are presented. Consequently, the following species have been transferred back to Periaptodes from Potemnemus: Periaptodes frater (Van de Poll, 1887), P. lictor Pascoe, 1866, P. olivieri (Thomson, 1864), P. potemnemoides Kriesche, 1936. P. testator Pascoe, 1866, P. paratestator Breuning, 1980. P

Following the results of the EMPA-REG OUTCOME trial with empagliflozin, is it possible to speak of a class effect?

Directory of Open Access Journals (Sweden)

Ampudia-Blasco FJ

2017-01-01

Full Text Available Francisco Javier Ampudia‑Blasco,1 Irene Romera,2 Bernat Ariño,3 Ramón Gomis4 1Endocrinology and Nutrition Department, Clinic University Hospital Valencia, Valencia, Spain; 2Eli Lilly and Company España, Madrid, Spain; 3Boehringer Ingelheim España, Barcelona, Spain; 4Endocrinology Department, Hospital Clinic Barcelona, Barcelona, Spain Background: The recently published cardiovascular outcomes data for the first sodium–glucose cotransporter 2 (SGLT2 inhibitor, empagliflozin, have shown cardiovascular safety and additional benefits in patients with type 2 diabetes and established cardiovascular disease. Empagliflozin showed lower rates of death from cardiovascular causes or from any causes and lower hospitalization rates from heart failure compared with placebo, both in addition to standard care. This commentary discusses the existence of a possible class effect considering the available evidence described for other SGLT2 inhibitors. Main text: Empagliflozin, dapagliflozin and canagliflozin share the same mechanism of action, and it is a plausible hypothesis that some of the benefits of empagliflozin treatment could also be expected from other SGLT2 inhibitors. However, the rapid and persistent occurrence of cardiovascular benefits observed with empagliflozin and the different results shown by the three inhibitors in meta-analyses of some of their respective Phase II and III trials might suggest another possible mechanism of action, perhaps related to the different selectivity to inhibit SGLT-2 and other SGLT family members that these compounds present. Conclusion: There is still lack of evidence to answer whether the cardiovascular benefits observed with empagliflozin in the EMPA-REG OUTCOME study could be seen as a “class effect”, which is also attributable to dapagliflozin and canagliflozin. Keywords: cardiovascular, outcome studies, SGLT2 inhibitors, empagliflozin, dapagliflozin, canagliflozin

Mast cell degranulation breaks peripheral tolerance.

Science.gov (United States)

de Vries, V C; Wasiuk, A; Bennett, K A; Benson, M J; Elgueta, R; Waldschmidt, T J; Noelle, R J

2009-10-01

Mast cells (MC) have been shown to mediate regulatory T-cell (T(reg))-dependent, peripheral allograft tolerance in both skin and cardiac transplants. Furthermore, T(reg) have been implicated in mitigating IgE-mediated MC degranulation, establishing a dynamic, reciprocal relationship between MC and T(reg) in controlling inflammation. In an allograft tolerance model, it is now shown that intragraft or systemic MC degranulation results in the transient loss of T(reg) suppressor activities with the acute, T-cell dependent rejection of established, tolerant allografts. Upon degranulation, MC mediators can be found in the skin, T(reg) rapidly leave the graft, MC accumulate in the regional lymph node and the T(reg) are impaired in the expression of suppressor molecules. Such a dramatic reversal of T(reg) function and tissue distribution by MC degranulation underscores how allergy may causes the transient breakdown of peripheral tolerance and episodes of acute T-cell inflammation.

T cell suppression by naturally occurring HLA-G-expressing regulatory CD4+ T cells is IL-10-dependent and reversible.

Science.gov (United States)

Huang, Yu-Hwa; Zozulya, Alla L; Weidenfeller, Christian; Schwab, Nicholas; Wiendl, Heinz

2009-08-01

CD4(+) T cells constitutively expressing the immune-tolerogenic HLA-G have been described recently as a new type of nT(reg) (HLA-G(pos) T(reg)) in humans. HLA-G(pos) T(reg) accumulate at sites of inflammation and are potent suppressors of T cell proliferation in vitro, suggesting their role in immune regulation. We here characterize the mechanism of how CD4(+) HLA-G(pos) T(reg) influence autologous HLA-G(neg) T(resp) function. Using a suppression system free of APC, we demonstrate a T-T cell interaction, resulting in suppression of HLA-G(neg) T(resp), which is facilitated by TCR engagement on HLA-G(pos) T(reg). Suppression is independent of cell-cell contact and is reversible, as the removal of HLA-G(pos) T(reg) from the established coculture restored the proliferative capability of responder cells. Further, HLA-G(pos) T(reg)-mediated suppression critically depends on the secretion of IL-10 but not TGF-beta.

Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy.

Science.gov (United States)

Chen, Jiahuan; Ganguly, Anutosh; Mucsi, Ashley D; Meng, Junchen; Yan, Jiacong; Detampel, Pascal; Munro, Fay; Zhang, Zongde; Wu, Mei; Hari, Aswin; Stenner, Melanie D; Zheng, Wencheng; Kubes, Paul; Xia, Tie; Amrein, Matthias W; Qi, Hai; Shi, Yan

2017-02-01

Dendritic cells are targeted by regulatory T (T reg) cells, in a manner that operates as an indirect mode of T cell suppression. In this study, using a combination of single-cell force spectroscopy and structured illumination microscopy, we analyze individual T reg cell-DC interaction events and show that T reg cells exhibit strong intrinsic adhesiveness to DCs. This increased DC adhesion reduces the ability of contacted DCs to engage other antigen-specific cells. We show that this unusually strong LFA-1-dependent adhesiveness of T reg cells is caused in part by their low calpain activities, which normally release integrin-cytoskeleton linkage, and thereby reduce adhesion. Super resolution imaging reveals that such T reg cell adhesion causes sequestration of Fascin-1, an actin-bundling protein essential for immunological synapse formation, and skews Fascin-1-dependent actin polarization in DCs toward the T reg cell adhesion zone. Although it is reversible upon T reg cell disengagement, this sequestration of essential cytoskeletal components causes a lethargic state of DCs, leading to reduced T cell priming. Our results reveal a dynamic cytoskeletal component underlying T reg cell-mediated DC suppression in a contact-dependent manner. © 2017 Chen et al.

MAR binding protein SMAR1 favors IL-10 mediated regulatory T cell function in acute colitis

Energy Technology Data Exchange (ETDEWEB)

Mirlekar, Bhalchandra; Patil, Sachin [Chromatin and Disease Biology Laboratory, National Centre for Cell Science, Ganeshkhind, Pune 411007 (India); Bopanna, Ramanamurthy [Experimental Animal Facility, National Centre for Cell Science, Ganeshkhind, Pune 411007 (India); Chattopadhyay, Samit, E-mail: samit@nccs.res.in [Chromatin and Disease Biology Laboratory, National Centre for Cell Science, Ganeshkhind, Pune 411007 (India)

2015-08-21

T{sub reg} cells are not only crucial for controlling immune responses to autoantigens but also prevent those directed towards commensal pathogens. Control of effector immune responses by T{sub reg} cells depend on their capacity to accumulate at inflammatory site and accordingly accommodate to inflammatory environment. Till date, the factors associated with maintaining these aspects of T{sub reg} phenotype is not understood properly. Here we have shown that a known nuclear matrix binding protein SMAR1 is selectively expressed more in colonic T{sub reg} cells and is required for their ability to accumulate at inflammatory site and to sustain high levels of Foxp3 and IL-10 expression during acute colitis. Elimination of anti-inflammatory subsets revealed a protective role for IL-10 producing T{sub reg} cells in SMAR1{sup −/−} mice. Moreover, a combined action of Foxp3 and SMAR1 restricts effector cytokine production and enhance the production of IL-10 by colonic T{sub reg} cells that controls acute colitis. This data highlights a critical role of SMAR1 in maintaining T{sub reg} physiology during inflammatory disorders. - Highlights: • SMAR1 is essential to sustain high level of Foxp3 and IL-10 in T{sub reg} cells. • SMAR1{sup −/−} T{sub reg} cells produce pro-inflammatory cytokine IL-17 leads to inflammation. • IL-10 administration can control the inflammation in SMAR1{sup −/−} mice. • Both Foxp3 and SMAR1 maintain T{sub reg} phenotype that controls colitis.

40 CFR 52.170 - Identification of plan.

Science.gov (United States)

2010-07-01

...) Chapter 14—CAIR NO X Ozone Season Trading Program General Provisions Reg. 19.1401 Adoption of Regulations 07/15/07 09/26/07 (72 FR 54556) Reg. 19.1402 State Trading Budget 07/15/07 09/26/07 (72 FR 54556) Reg... Offsets 07/03/06 04/12/07 (72 FR 18394) Reg. 31.305 Zones Targeted for Economic Development 07/03/06 04/12...

Listado anotado de Solanum L. (Solanaceae) en el Perú

DEFF Research Database (Denmark)

Särkinen, Tiina; Baden, Maria; Gonzáles, Paúl

2015-01-01

), and Canta and Huarochirí (Lima). Secondary centres of endemism with high concentrations of both endemics and near-endemics are found in San Ignacio and Cutervo (Cajamarca), Santiago de Chuco (La Libertad), Oxapampa (Pasco), and Cusco (Cusco). Current diversity patterns are highly correlated with collection...

Representation of monsoon intraseasonal oscillations in regional climate model: sensitivity to convective physics

KAUST Repository

Umakanth, U.

2015-11-07

The aim of the study is to evaluate the performance of regional climate model (RegCM) version 4.4 over south Asian CORDEX domain to simulate seasonal mean and monsoon intraseasonal oscillations (MISOs) during Indian summer monsoon. Three combinations of Grell (G) and Emanuel (E) cumulus schemes namely, RegCM-EG, RegCM-EE and RegCM-GE have been used. The model is initialized at 1st January, 2000 for a 13-year continuous simulation at a spatial resolution of 50 km. The models reasonably simulate the seasonal mean low level wind pattern though they differ in simulating mean precipitation pattern. All models produce dry bias in precipitation over Indian land region except in RegCM-EG where relatively low value of dry bias is observed. On seasonal scale, the performance of RegCM-EG is more close to observation though it fails at intraseasonal time scales. In wave number-frequency spectrum, the observed peak in zonal wind (850 hPa) at 40–50 day scale is captured by all models with a slight change in amplitude, however, the 40–50 day peak in precipitation is completely absent in RegCM-EG. The space–time characteristics of MISOs are well captured by RegCM-EE over RegCM-GE, however it fails to show the eastward propagation of the convection across the Maritime Continent. Except RegCM-EE all other models completely underestimates the moisture advection from Equatorial Indian Ocean onto Indian land region during life-cycle of MISOs. The characteristics of MISOs are studied for strong (SM) and weak (WM) monsoon years and the differences in model performances are analyzed. The wavelet spectrum of rainfall over central India denotes that, the SM years are dominated by high frequency oscillations (period <20 days) whereas little higher periods (>30 days) along with dominated low periods (<20 days) observed during WM years. During SM, RegCM-EE is dominated with high frequency oscillations (period <20 days) whereas in WM, RegCM-EE is dominated with periods >20�

Major Risk Factors for Heart Disease: Diabetes

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... Red Dress &reg , and Red Dress &reg are registered trademarks of U.S. Department of Health and Human Services. National Wear Red Day &reg is a registered trademark of the U.S. Department of Health and Human ...

Tests That Can Help Protect Your Heart Health

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... Red Dress &reg , and Red Dress &reg are registered trademarks of U.S. Department of Health and Human Services. National Wear Red Day &reg is a registered trademark of the U.S. Department of Health and Human ...

Medications

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... Red Dress &reg , and Red Dress &reg are registered trademarks of U.S. Department of Health and Human Services. National Wear Red Day &reg is a registered trademark of the U.S. Department of Health and Human ...

Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia.

Science.gov (United States)

Biancotto, Angélique; Dagur, Pradeep K; Fuchs, John C; Wiestner, Adrian; Bagwell, C Bruce; McCoy, J Philip

2012-02-01

Increased numbers of T regulatory (T(reg)) cells are found in B-chronic lymphocytic leukemia, but the nature and function of these T(regs) remains unclear. Detailed characterization of the T(regs) in chronic lymphocytic leukemia has not been performed and the degree of heterogeneity of among these cells has not been studied to date. Using 15-color flow cytometry we show that T(reg) cells, defined using CD4, CD25, and forkhead box P3 (FOXP3), can be divided into multiple complex subsets based on markers used for naïve, memory, and effector delineation as well as markers of T(reg) activation. Furthermore FOXP3(+) cells can be identified among CD4(+)CD25(-) as well as CD8(+)CD4(-) populations in increased proportions in patients with chronic lymphocytic leukemia compared with healthy donors. Significantly different frequencies of naïve and effector T(regs) populations are found in healthy donor controls compared with donors with chronic lymphocytic leukemia. A population of CCR7(+)CD39(+) T(regs) was significantly associated with chronic lymphocytic leukemia. This population demonstrated slightly reduced suppressive activity compared with total T(regs) or T(regs) of healthy donors. These data suggest that FOXP3-expressing cells, particularly in patients with chronic lymphocytic leukemia are much more complex for T(reg) sub-populations and transitions than previously reported. These findings demonstrate the complexity of regulation of T-cell responses in chronic lymphocytic leukemia and illustrate the use of high-dimensional analysis of cellular phenotypes in facilitating understanding of the intricacies of cellular immune responses and their dysregulation in cancer.

Impact of Irgarol 1051 on the larval development and metamorphosis of Balanus amphitirite Darwin, diatom, Amphora coffeaformis and natural biofilm

Digital Repository Service at National Institute of Oceanography (India)

Desai, D.V.

, Florida, USA. Mar Pollut Bull. 44(8):781-788. Gibbs PE, Pascoe PL, Burt GR. 1988. Sex change in the female dog-whelk Nucella lapillus, induced by tributyltin from antifouling paints. J Mar Biol Assoc UK. 68:715-731. Gómez-Ariza JL, Santos MM, Morales E...

Distribución espacial de los accidentes y enfermedades relacionados con el trabajo en el Perú, 2012-2014

Directory of Open Access Journals (Sweden)

Akram Hernández-Vásquez

2016-01-01

Full Text Available Se analizaron geoespacialmente los accidentes, incidentes peligrosos y enfermedades ocupacionales que se reportaron a nivel regional en el Perú (2012-2014. 52 887 eventos se notificaron entre accidentes de trabajo (93%, incidentes peligrosos (5,1%, enfermedades ocupacionales (1% y accidentes mortales (0,9%. Se evidenciaron altas tasas de accidentes mortales en Pasco, Callao, Lima, Moquegua y Arequipa. Callao y Lima son las regiones con tasas más altas de accidentes de trabajo. Las mayores tasas de incidentes peligrosos se reportaron en Arequipa, Callao, Lima, Ica y Piura. Las enfermedades ocupacionales se distribuyeron con altas tasas en Huancavelica, Ancash, Pasco, Callao y Cusco. La explotación de minas y canteras (49,2%; seguida por la industria manufacturera (23,4%; y, la construcción (8% son las actividades económicas que concentraron elevadas tasas de enfermedades ocupacionales. Se concluye que existen altas tasas y patrones espaciales comunes de accidentabilidad en el Perú que pueden servir para enfocar intervenciones.

Temperature rise and Heat build up inside a parked Car

Science.gov (United States)

Coady, Rose; Maheswaranathan, Ponn

2001-11-01

We have studied the heat build up inside a parked car under the hot summer Sun. Inside and outside temperatures were monitored every ten seconds from 9 AM to about 4 PM for a 2000 Toyota Camry parked in a Winthrop University parking lot without any shades or trees. Two PASCO temperature sensors, one inside the car and the other outside the car, are used along with PASCO-750 interface to collect the data. Data were collected under the following conditions while keeping track of the outside weather: fully closed windows, slightly open windows, half way open windows, fully open windows, and with window shades inside and outside. Inside temperatures reached as high as 150 degrees Fahrenheit on a sunny day with outside high temperature of about 100 degrees Fahrenheit. These results will be presented along with results from car cover and window tint manufacturers and suggestions to keep your car cool next time you park it under the Sun.

Surface hydrologic investigations of the Columbia Plateau Region, Washington

International Nuclear Information System (INIS)

Leonhart, L.S.

1979-07-01

The Washington State portion of the Columbia Plateau is divided into six hydrologic sub-basins on the basis of the principal surface drainage systems present, structural and topographic relationships, and political and other considerations. Baseline descriptions of the surface water systems and resources are presented for the Columbia Plateau with emphasis on the Pasco Sub-basin. A preliminary evaluation of the hydrologic budget for each sub-basin is derived. For each sub-basin, recharge/discharge relationships arising from precipitation/evapotranspiration/runoff, stream losses and gains, and artificial mechanisms are determined on the basis of available data. The net exchange between surface and groundwater systems is evaluated and relative estimates of the net groundwater flow into or out of the sub-basin are obtained. An evaluation is made of hydrologic risk factors arising from: (1) tributary flooding in eastern Washington; and, (2) major flooding of the Columbia River within the Pasco Sub-basin. Scenarios are presented for credible natural and man-generated catastrophic events

Pacific Northwest Laboratory monthly activities report, November 1967

Energy Technology Data Exchange (ETDEWEB)

Albaugh, F.W.

1967-12-01

Calculated temperatures permitted in the Columbia River under various suggested regulations were plotted and reported in support of AEC studies. Mechanisms of Environmental Exposure. Measurements of radioactivity were completed in 362 pupils and 5 teachers at Emerson School on November 17. Measurements will begin at the third Pasco elementary school on December 5. Lectures were given at Mark Twain School to the teaching staff on November 20, and to 23 classroom son November 27 through December 1. A lecture was also given to the PTA meeting the evening of November 20 at Robert Frost elementary school in Pasco. Modifications were made to the electronic equipment and to the mobile whole-body counter van to improve the performance of the facility to further protect the NaI crystal from potential cold weather damage. Errors found inn the computer-calculated environmental doses were being corrected at month`s end, and the doses will be recalculated in December.

Surface hydrologic investigations of the Columbia Plateau region, Washington

International Nuclear Information System (INIS)

Leonhart, L.S.

1979-01-01

The Washington State portion of the Columbia Plateau is divided into six hydrologic sub-basins on the basis of the principal surface drainage systems present, structural and topographic relationships, and political and other considerations. Baseline descriptions of the surface water systems and resources are presented for the Columbia Plateau with emphasis on the Pasco Sub-basin. A preliminary evaluation of the hydrologic budget for each sub-basin is derived. For each sub-basin, recharge/discharge relationships arising from precipitation/evapotranspiration/runoff, stream losses and gains, and artificial mechanisms are determined on the basis of available data. The net exchange between surface and ground-water systems is evaluated and relative estimates of the net ground-water flow into or out of the sub-basin are obtained. An evaluation is made of hydrologic risk factors arising from: (1) tributary flooding in eastern Washington; and (2) major flooding of the Columbia River within the Pasco Sub-basin. Scenarios are presented for credible natural and man-generated catastrophic events

Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial

Science.gov (United States)

Fitchett, David; Zinman, Bernard; Wanner, Christoph; Lachin, John M.; Hantel, Stefan; Salsali, Afshin; Johansen, Odd Erik; Woerle, Hans J.; Broedl, Uli C.; Inzucchi, Silvio E.

2016-01-01

Abstract Aims We previously reported that in the EMPA-REG OUTCOME® trial, empagliflozin added to standard of care reduced the risk of 3-point major adverse cardiovascular events, cardiovascular and all-cause death, and hospitalization for heart failure in patients with type 2 diabetes and high cardiovascular risk. We have now further investigated heart failure outcomes in all patients and in subgroups, including patients with or without baseline heart failure. Methods and results Patients were randomized to receive empagliflozin 10 mg, empagliflozin 25 mg, or placebo. Seven thousand and twenty patients were treated; 706 (10.1%) had heart failure at baseline. Heart failure hospitalization or cardiovascular death occurred in a significantly lower percentage of patients treated with empagliflozin [265/4687 patients (5.7%)] than with placebo [198/2333 patients (8.5%)] [hazard ratio, HR: 0.66 (95% confidence interval: 0.55–0.79); P heart failure hospitalization or cardiovascular death of 35 over 3 years. Consistent effects of empagliflozin were observed across subgroups defined by baseline characteristics, including patients with vs. without heart failure, and across categories of medications to treat diabetes and/or heart failure. Empagliflozin improved other heart failure outcomes, including hospitalization for or death from heart failure [2.8 vs. 4.5%; HR: 0.61 (0.47–0.79); P heart failure at baseline in both treatment groups, but were no more common with empagliflozin than with placebo. Conclusion In patients with type 2 diabetes and high cardiovascular risk, empagliflozin reduced heart failure hospitalization and cardiovascular death, with a consistent benefit in patients with and without baseline heart failure. PMID:26819227

1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis.

Science.gov (United States)

Wei, Chunyan; Mei, Jie; Tang, Lingli; Liu, Yukai; Li, Dajin; Li, Mingqing; Zhu, Xiaoyong

2016-12-01

Foxp3 + regulatory T (T reg ) cells contribute to the local dysfunctional immune environment in endometriosis, an estrogen-dependent gynecological disease, which affects the function of ectopic endometrial tissue clearance by the immune system. The reason for the high percentage of peritoneal T reg in endometriosis patients is unknown. Here, we show that the proportion of peritoneal T reg cells increases as endometriosis progresses. To determine the probable mechanism, we established a naive T cell-macrophage-endometrial stromal cell (ESC) co-culture system to mimic the peritoneal cavity microenvironment. After adding 1-methyl-tryptophan (1-MT), a specific inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1), to the co-culture system, we found that the differentiation of T reg cells, mainly IL-10 + T reg cells, decreased. Therefore, 1-MT-pretreated ESCs-educated T reg cells performed impaired suppressive function. Moreover, estrogen promoted the differentiation of T reg cells by elevating IDO1 expression in the ectopic lesion. Subsequently, we examined mannose receptor C, type 2 (MRC2), which is an up-stream molecule of IL-10, by bioinformatics analysis and real-time PCR validation. MRC2 expression in ectopic ESCs was notably lower than that in normal ESCs, which further negatively regulated the expression of IDO1 and Ki-67 in ESCs. Furthermore, MRC2 is required for T reg differentiation in the ectopic lesion, especially that for CD4 high T reg . Therefore, MRC2-silenced ESCs-educated T reg manifested a stronger suppressive function in vitro. Consistently, the percentage of T reg increased when MRC2-shRNA was administered in the peritoneal cavity of endometriosis-disease mice model. Besides, 1-MT improved the condition of endometriosis, in terms of reducing the number and weight of total ectopic lesions in vivo. These results indicate that the estrogen-IDO1-MRC2 axis participates in the differentiation and function of T reg and is involved in the development of

FOXP3+ regulatory T cells in normal prostate tissue, postatrophic hyperplasia, prostatic intraepithelial neoplasia, and tumor histological lesions in men with and without prostate cancer.

Science.gov (United States)

Davidsson, Sabina; Andren, Ove; Ohlson, Anna-Lena; Carlsson, Jessica; Andersson, Swen-Olof; Giunchi, Francesca; Rider, Jennifer R; Fiorentino, Michelangelo

2018-01-01

The tumor promoting or counteracting effects of the immune response to cancer development are thought to be mediated to some extent by the infiltration of regulatory T cells (T regs ). In the present study we evaluated the prevalence of T reg populations in stromal and epithelial compartments of normal, post atrophic hyperplasia (PAH), prostatic intraepithelial neoplasia (PIN), and tumor lesions in men with and without prostate cancer. Study subjects were 102 men consecutively diagnosed with localized prostate cancer undergoing radical prostatectomy and 38 men diagnosed with bladder cancer undergoing cystoprostatectomy without prostate cancer at the pathological examination. Whole mount sections from all patients were evaluated for the epithelial and stromal expression of CD4 + T regs and CD8 + T regs in normal, PAH, PIN, and tumor lesions. A Friedmańs test was used to investigate differences in the mean number of T regs across histological lesions. Logistic regression was used to estimate crude and adjusted odds ratios (OR) for prostate cancer for each histological area. In men with prostate cancer, similarly high numbers of stromal CD4 + T regs were identified in PAH and tumor, but CD4 + T regs were less common in PIN. Greater numbers of epithelial CD4+ T regs in normal prostatic tissue were positively associated with both Gleason score and pT-stage. We observed a fourfold increased risk of prostate cancer in men with epithelial CD4 + T regs in the normal prostatic tissue counterpart. Our results may suggest a possible pathway through which PAH develops directly into prostate cancer in the presence of CD4 + T regs and indicate that transformation of the anti-tumor immune response may be initiated even before the primary tumor is established. © 2017 The Authors. The Prostate Published by Wiley Periodicals Inc.

Natural product antifoulants

Digital Repository Service at National Institute of Oceanography (India)

Raveendran, T.V.; Mol, V.P.L.

, regulations, prospects. Mar. Environ. Res., 1991, 32, 7–17. 12. Gibbs, P. E., Bryan, G. W., Pascoe, P. L. and Burt, G. R., The use of the dog-whelk, Nucella lapillus, as an indicator of tributyl tin (TBT) contamination. J. Mar. Biol. Ass. UK, 1987, 67, 507...

Elleanthus albiflorus (Orchidaceae) a new, white-flowered species from Peru

Czech Academy of Sciences Publication Activity Database

Dudek, M.; Baranow, P.; Kolanowska, Marta; Rykaczewski, M.

2017-01-01

Roč. 312, č. 2 (2017), s. 256-262 ISSN 1179-3155 R&D Projects: GA ČR GB14-36098G Institutional support: RVO:86652079 Keywords : biodiversity * Epidendroideae * morphology * Pasco Region * taxonomy Subject RIV: EF - Botanics OBOR OECD: Plant sciences, botany Impact factor: 1.240, year: 2016

Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia.

Science.gov (United States)

Weiss, Lukas; Melchardt, Thomas; Egle, Alexander; Grabmer, Christoph; Greil, Richard; Tinhofer, Inge

2011-05-15

Early stage chronic lymphocytic leukemia is characterized by a highly variable course of disease. Because it is believed that regulatory T cells (T(regs) ) are potent suppressors of antitumor immunity, the authors hypothesized that increased T(regs) may favor disease progression. T(reg) levels (cluster of differentiation 3 [CD3]-positive, [CD4]-positive, CD25-positive, and CD127-negative) in peripheral blood from 102 patients were analyzed by flow cytometry. Statistical analysis was used to evaluate correlations with clinical data. The relative T(reg) numbers in CD4-positive T cells were significantly greater in patients with chronic lymphocytic leukemia compared with the numbers in a control group of 170 healthy individuals (P = .001). Patients were divided into 2 groups using a median T(reg) value of 9.7% (the percentage of CD4-positive T cells). Patients with higher T(reg) levels had a significantly shorter time to initial treatment (median, 5.9 years) compared with patients who had lower T(reg) levels (median, 11.7 years; log-rank P = .019). Furthermore, T(reg) levels (the percentage of CD4-positive T cells) had significant prognostic power to predict the time to initial treatment in univariate analysis (P = .023) and in multivariate Cox regression analysis that included the variables Rai stage, immunoglobulin heavy-chain variable region gene mutational status, chromosomal aberrations, and CD38 expression (P = .028). Higher T(reg) levels had significant and independent prognostic power for predicting the time to initial treatment in patients with low to intermediate stage chronic lymphocytic leukemia. 2010 American Cancer Society.

Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth

Science.gov (United States)

Hutzler, Marina; Abel, Simone; Alter, Christina; Stockmann, Christian; Kliche, Stefanie; Albert, Juliane; Sparwasser, Tim; Sakaguchi, Shimon; Westendorf, Astrid M.; Schadendorf, Dirk; Buer, Jan; Helfrich, Iris

2012-01-01

Infiltration of Foxp3+ regulatory T (T reg) cells is considered to be a critical step during tumor development and progression. T reg cells supposedly suppress locally an effective anti-tumor immune response within tumor tissues, although the precise mechanism by which T reg cells infiltrate the tumor is still unclear. We provide evidence that Neuropilin 1 (Nrp-1), highly expressed by Foxp3+ T reg cells, regulates the immunological anti-tumor control by guiding T reg cells into the tumor in response to tumor-derived vascular endothelial growth factor (VEGF). We demonstrate for the first time that T cell–specific ablation of Nrp-1 expression results in a significant breakdown in tumor immune escape in various transplantation models and in a spontaneous, endogenously driven melanoma model associated with strongly reduced tumor growth and prolonged tumor-free survival. Strikingly, numbers of tumor-infiltrating Foxp3+ T reg cells were significantly reduced accompanied by enhanced activation of CD8+ T cells within tumors of T cell–specific Nrp-1–deficient mice. This phenotype can be reversed by adoptive transfer of Nrp-1+ T reg cells from wild-type mice. Thus, our data strongly suggest that Nrp-1 acts as a key mediator of Foxp3+ T reg cell infiltration into the tumor site resulting in a dampened anti-tumor immune response and enhanced tumor progression. PMID:23045606

xdamp Version 6 : an IDL-based data and image manipulation program.

Energy Technology Data Exchange (ETDEWEB)

Ballard, William Parker

2012-04-01

The original DAMP (DAta Manipulation Program) was written by Mark Hedemann of Sandia National Laboratories and used the CA-DISSPLA{trademark} (available from Computer Associates International, Inc., Garden City, NY) graphics package as its engine. It was used to plot, modify, and otherwise manipulate the one-dimensional data waveforms (data vs. time) from a wide variety of accelerators. With the waning of CA-DISSPLA and the increasing popularity of Unix(reg sign)-based workstations, a replacement was needed. This package uses the IDL(reg sign) software, available from Research Systems Incorporated, a Xerox company, in Boulder, Colorado, as the engine, and creates a set of widgets to manipulate the data in a manner similar to the original DAMP and earlier versions of xdamp. IDL is currently supported on a wide variety of Unix platforms such as IBM(reg sign) workstations, Hewlett Packard workstations, SUN(reg sign) workstations, Microsoft(reg sign) Windows{trademark} computers, Macintosh(reg sign) computers and Digital Equipment Corporation VMS(reg sign) and Alpha(reg sign) systems. Thus, xdamp is portable across many platforms. We have verified operation, albeit with some minor IDL bugs, on personal computers using Windows 7 and Windows Vista; Unix platforms; and Macintosh computers. Version 6 is an update that uses the IDL Virtual Machine to resolve the need for licensing IDL.

Preliminary investigation of the magnetostratigraphy of the Ringold Formation

International Nuclear Information System (INIS)

Packer, D.R.; Johnston, J.M.

1979-05-01

The Ringold Formation consists of lacustrine and fluvial deposits overlying the Columbia River Basalt. The Ringold Formation, because of its thickness, extent, and age, is an excellent unit in which to detect and possibly data the deformation that has occurred since deposition of the basalt. One objective of this study was to investigate the paleomagnetism of the upper Ringold unit exposed at one location in the White Bluffs in enough detail to resolve, with reasonable confidence, the magnetostratigraphy of the rock units sampled. The other objective was to evaluate, in a preliminary manner, the paleomagnetic favorability and magnetostratigraphy of the subsurface Ringold Formation in the Pasco Basin and at selected exposures outside the Pasco Basin. The scope of this study was the collection of 300 paleomagnetic samples, their measurement, and analysis. Samples were collected from the White Bluffs, from core recovered from six drill holes on the Hanford Site, and from two surface exposures outside the Pasco Basin. A total of 294 samples was collected, and 2928 paleomagnetic measurements were performed on these samples. The samples were measured by means of a three-axis super-conducting rock magnetometer having a sensitivity of 10 -8 emu/cm 3 and were demagnetized progressively in a 400-hertz alternating field (AF). All data were recorded and processed during measurement by an on-line computer.The declination, inclination, and intensity of magnetization of the samples from the various sections are plotted as a function of their stratigraphic position. The directions of the magnetization of the various sections are also plotted as a group on Wulff equal-angle stereonets. 22 figures, 8 tables

581 Refresher course.indd

African Journals Online (AJOL)

16(2) ... or short children. In certain subgroups, e.g. brain injury and blunt trauma, higher SBP seems to improve outcome. In everyday anaesthesia practice, SBP is monitored more often than MAP. .... of television watched per day. Although we ...

Refresher Course in Mathematics

Indian Academy of Sciences (India)

at Department of Mathematics, Berhampur University, Berhampur 760007, Orissa ... Applications are invited. from University/College teachers and Researchers interested in ... Pre-requisites: A basic knowledge of analysis, topology, differential ...

CD4+ CD25+ CD127low Regulatory T Cells as Indicator of Rheumatoid Arthritis Disease Activity.

Science.gov (United States)

Khattab, Sahar S; El-Saied, Amany M; Mohammed, Rehab A; Mohamed, Eman E

2016-06-01

Rheumatoid arthritis (RA) is an autoimmune disease characterized by disturbed immune regulation, inducing a progressive cartilage and bone destruction. Despite enrichment of T regulatory cell (T-regs) in synovial fluid, conflicting results are reported concerning T-regs in peripheral blood (PB) of RA patients. To determine possible correlation between the frequency of PB CD4+ CD25+CD127low (T-regs) with RA disease activity. Forty females with RA, classified according to the Disease Activity Score 28 (DAS-28), as highly active, mild-moderate or low disease activity; and 20 age and sex matched healthy controls, were enrolled to study CD4+ CD25+ CD127low T- regs in PB by flow cytometry. Active RA patients had lower frequency of the CD4+ CD25+ CD127low T- regs compared to those with mild-moderate or low disease activity (P <0.001). The frequencies of the T- regs showed negative correlation with the DAS-28 (P<0.01). In conclusion, CD4+ CD25+ CD127low T-regs is significantly lower in highly active RA patients compared to patients with lower activity or controls. Copyright© by the Egyptian Association of Immunologists.

Expression and localization of regenerating gene I in a rat liver regeneration model

International Nuclear Information System (INIS)

Wang Jingshu; Koyota, Souichi; Zhou, Xiaoping; Ueno, Yasuharu; Ma Li; Kawagoe, Masami; Koizumi, Yukio; Okamoto, Hiroshi; Sugiyama, Toshihiro

2009-01-01

Regenerating gene (Reg) I has been identified as a regenerative/proliferative factor for pancreatic islet cells. We examined Reg I expression in the regenerating liver of a rat model that had been administered 2-acetylaminofluorene and treated with 70% partial hepatectomy (2-AAF/PH model), where hepatocyte and cholangiocyte proliferation was suppressed and the hepatic stem cells and/or hepatic progenitor cells were activated. In a detailed time course study of activation of hepatic stem cells in the 2-AAF/PH model, utilizing immunofluorescence staining with antibodies of Reg I and other cell-type-specific markers, we found that Reg I-expressing cells are present in the bile ductules and increased during regeneration. Reg I-expressing cells were colocalized with CK19, OV6, and AFP. These results demonstrate that Reg I is significantly upregulated in the liver of the 2-AAF/PH rat model, accompanied by the formation of bile ductules during liver regeneration.

Vom work Book Journal, 2011 3rd Edition

African Journals Online (AJOL)

USER

In: HARARI, J.: Surgical. Complication of Wound Healing in the Small Animal. Practice. W. B. Saunders Company 143-146. MULLER, G. H., KIRK, R. W. and SCOTT, D. W. (1998): th. Small animal dermatology, 4 Ed. W. B. Saunders. Company, Philadelphia. 771-775. PASCOE, R. R. (1981): Equine dermatoses. Syndey,.

Resonance – Journal of Science Education | Indian Academy of ...

Indian Academy of Sciences (India)

2016 Nobel Prize in Chemistry: Conferring Molecular Machines as Engines of Creativity ... Science Academies' 92nd Refresher Course in Experimental Physics ... Science Academies' Refresher Course on Advances in Molecular Biology.

Representation of monsoon intraseasonal oscillations in regional climate model: sensitivity to convective physics

KAUST Repository

Umakanth, U.; Kesarkar, Amit P.; Attada, Raju; Vijaya Bhaskar Rao, S.

2015-01-01

combinations of Grell (G) and Emanuel (E) cumulus schemes namely, RegCM-EG, RegCM-EE and RegCM-GE have been used. The model is initialized at 1st January, 2000 for a 13-year continuous simulation at a spatial resolution of 50 km. The models reasonably simulate

Exacerbation of spontaneous autoimmune nephritis following regulatory T cell depletion in B cell lymphoma 2-interacting mediator knock-out mice.

Science.gov (United States)

Wang, Y M; Zhang, G Y; Wang, Y; Hu, M; Zhou, J J; Sawyer, A; Cao, Q; Wang, Y; Zheng, G; Lee, V W S; Harris, D C H; Alexander, S I

2017-05-01

Regulatory T cells (T regs ) have been recognized as central mediators for maintaining peripheral tolerance and limiting autoimmune diseases. The loss of T regs or their function has been associated with exacerbation of autoimmune disease. However, the temporary loss of T regs in the chronic spontaneous disease model has not been investigated. In this study, we evaluated the role of T regs in a novel chronic spontaneous glomerulonephritis model of B cell lymphoma 2-interacting mediator (Bim) knock-out mice by transient depleting T regs . Bim is a pro-apoptotic member of the B cell lymphoma 2 (Bcl-2) family. Bim knock-out (Bim -/- ) mice fail to delete autoreactive T cells in thymus, leading to chronic spontaneous autoimmune kidney disease. We found that T reg depletion in Bim -/- mice exacerbated the kidney injury with increased proteinuria, impaired kidney function, weight loss and greater histological injury compared with wild-type mice. There was a significant increase in interstitial infiltrate of inflammatory cells, antibody deposition and tubular damage. Furthermore, the serum levels of cytokines interleukin (IL)-2, IL-4, IL-6, IL-10, IL-17α, interferon (IFN)-γ and tumour necrosis factor (TNF)-α were increased significantly after T reg depletion in Bim -/- mice. This study demonstrates that transient depletion of T regs leads to enhanced self-reactive T effector cell function followed by exacerbation of kidney disease in the chronic spontaneous kidney disease model of Bim-deficient mice. © 2017 British Society for Immunology.

Rehearsal in serial recall: An unworkable solution to the nonexistent problem of decay.

Science.gov (United States)

Lewandowsky, Stephan; Oberauer, Klaus

2015-10-01

We examine the explanatory roles that have been ascribed to various forms of rehearsal or refreshing in short-term memory (STM) and working memory paradigms, usually in conjunction with the assumption that memories decay over time if they are not rehearsed. Notwithstanding the popularity of the rehearsal notion, there have been few detailed examinations of its underlying mechanisms. We explicitly implemented rehearsal in a decay model and explored its role by simulation in several benchmark paradigms ranging from immediate serial recall to complex span and delayed recall. The results show that articulatory forms of rehearsal often fail to counteract temporal decay. Rapid attentional refreshing performs considerably better, but so far there is scant empirical evidence that people engage in refreshing during STM tasks. Combining articulatory rehearsal and refreshing as 2 independent maintenance processes running in parallel leads to worse performance than refreshing alone. We conclude that theoretical reliance on articulatory rehearsal as a causative agent in memory may be unwise and that explanatory appeals to rehearsal are insufficient unless buttressed by quantitative modeling. (c) 2015 APA, all rights reserved).

33 CFR 117.1058 - Snake River.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Snake River. 117.1058 Section 117... OPERATION REGULATIONS Specific Requirements Washington § 117.1058 Snake River. (a) The draw of the Burlington Northern Santa Fe railroad bridge across the Snake River at mile 1.5 between Pasco and Burbank is...

Telemetry with an Optical Fiber Revisited: An Alternative Strategy

Science.gov (United States)

Kraftmakher, Yaakov

2014-01-01

With a new data-acquisition system developed by PASCO scientific, an experiment on telemetry with an optical fiber can be made easier and more accurate. For this aim, an alternative strategy of the remote temperature measurements is proposed: the frequency of light pulses transmitted via the light guide numerically equals the temperature using…

75 FR 47769 - Animal Traceability; Public Meetings

Science.gov (United States)

2010-08-09

..., Madison, WI 53704. The public meeting on August 20, 2010, will be held at the Doubletree Hotel Atlanta... at the Red Lion Hotel, 2525 North 20th Avenue, Pasco, WA 99301. FOR FURTHER INFORMATION CONTACT: Mr... States. In keeping with its commitment to partnering with States, Tribal Nations, and industry to address...

21 CFR 184.1257 - Clove and its derivatives.

Science.gov (United States)

2010-04-01

... Eugenia caryophyllata Thunberg, native to tropical Asia. Their derivatives include essential oils (cloves, CAS Reg. No. 8000-34-8; buds; leaves, CAS Reg. No. 8015-97-2; stems, CAS Reg. No. 8015-98-3; and... stems. (b) Clove bud oil, clove leaf oil, clove stem oil, and eugenol meet the specifications of the...

Reduction of regulatory T cells in skin lesions but not in peripheral blood of patients with systemic scleroderma.

Science.gov (United States)

Klein, S; Kretz, C C; Ruland, V; Stumpf, C; Haust, M; Hartschuh, W; Hartmann, M; Enk, A; Suri-Payer, E; Oberle, N; Krammer, P H; Kuhn, A

2011-08-01

To determine the frequency and suppressive capacity of regulatory T cells (T(reg)) and their association with clinical parameters in patients with systemic scleroderma (SSc). Peripheral blood from 25 patients with SSc, 15 patients with localised scleroderma (LS) and 29 healthy controls (HC) was studied. Analysis of CD4(+) forkhead box P3 (Foxp3)(+) and CD4(+)CD25(++)Foxp3(+) T(reg) subpopulations was carried out by flow cytometry and cell proliferation was quantified by (3)H-thymidine incorporation. Quantitative analysis of T(reg) was further performed in skin biopsies from 17 patients with SSc and 21 patients with LS using anti-CD4 and anti-Foxp3 monoclonal antibodies for immunohistochemistry. The frequency of CD4(+)Foxp3(+) and CD4(+)CD25(++)Foxp3(+) T(reg) in peripheral blood from patients with SSc was not significantly different from that of patients with LS or HC. The suppressive capacity of CD4(+)CD25(++) T(reg) in SSc was also found to be similar to that of HC. Phenotypic and functional data revealed no significant difference between the limited or diffuse form of SSc. Moreover, therapy with bosentan showed no significant effect on the frequency of T(reg) during the course of the disease. However, the frequency of T(reg) in skin lesions from patients with SSc or LS, determined as the percentage of CD4(+) cells expressing Foxp3 in the inflammatory infiltrate, was significantly reduced compared with other inflammatory skin diseases. These results indicate that although the authors found no defect in the frequency or function of peripheral T(reg) subpopulations, the reduction of CD4(+)Foxp3(+) T(reg) in the skin of patients with SSc may be important in the pathogenesis of the disease.

Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis.

Science.gov (United States)

Huang, Yu-Hwa; Zozulya, Alla L; Weidenfeller, Christian; Metz, Imke; Buck, Dorothea; Toyka, Klaus V; Brück, Wolfgang; Wiendl, Heinz

2009-08-01

We have recently described a novel population of natural regulatory T cells (T(reg)) that are characterized by the expression of HLA-G and may be found at sites of tissue inflammation (HLA-G(pos) T(reg)). Here we studied the role of these cells in multiple sclerosis (MS), a prototypic autoimmune inflammatory disorder of the central nervous system (CNS). Sixty-four patients with different types of MS, 9 patients with other neurological diseases, and 20 healthy donors were included in this study. Inflamed brain lesions from 5 additional untreated MS patients were examined. HLA-G(pos) T(reg) were analyzed in the cerebrospinal fluid (CSF) by flow cytometry and in inflammatory demyelinating lesions of MS brain specimens by immunohistochemistry. Functional capacity was accessed and transmigration was determined using an in vitro model of the human blood-brain barrier (BBB). HLA-G(pos) T(reg) were found enriched in the inflamed CSF of MS patients and in inflammatory demyelinating lesions of MS brain specimens. HLA-G(pos) T(reg) showed a strong propensity to transmigrate across BBB, which was vigorously driven by inflammatory chemokines, and associated with a gain of suppressive capacity upon transmigration. CSF-derived HLA-G(pos) T(reg) of MS patients represented a population of activated central memory activated T cells with an upregulated expression of inflammatory chemokine receptors and exhibiting full suppressive capacity. Unlike natural FoxP3-expressing T(reg), HLA-G(pos) T(reg) derived from peripheral blood were functionally unimpaired in MS. In MS, HLA-G(pos) T(reg) may serve to control potentially destructive immune responses directly at the sites of CNS inflammation and to counterbalance inflammation once specifically recruited to the CNS.

40 CFR 52.120 - Identification of plan.

Science.gov (United States)

2010-07-01

... Devices) 12-3-6(Penalty for Violation) 12-4-1(Shade, Density, or Opacity of Emissions) 12-4-2(Dust Control...) Sec. 2, Reg. 1(Shade, Density or Opacity of Emissions) Sec. 2, Reg. 2(Particulate Matter) Sec. 2, Reg...(Particulate Emissions: Portland Cement Plants) R9-3-308 (Particulate Emissions: Heater-Planers) Submitted on...

Perspectives on Regulatory T Cell Therapies.

Science.gov (United States)

Probst-Kepper, Michael; Kröger, Andrea; Garritsen, Henk S P; Buer, Jan

2009-01-01

Adoptive transfer in animal models clearly indicate an essential role of CD4+ CD25+ FOXP3+ regulatory T (T(reg)) cells in prevention and treatment of autoimmune and graft-versus-host disease. Thus, T(reg) cell therapies and development of drugs that specifically enhance T(reg) cell function and development represent promising tools to establish dominant tolerance. So far, lack of specific markers to differentiate human T(reg) cells from activated CD4+ CD25+ effector T cells, which also express FOXP3 at different levels, hampered such an approach. Recent identification of the orphan receptor glycoprotein-A repetitions predominant (GARP or LRRC32) as T(reg) cell-specific key molecule that dominantly controls FOXP3 via a positive feedback loop opens up new perspectives for molecular and cellular therapies. This brief review focuses on the role of GARP as a safeguard of a complex regulatory network of human T(reg) cells and its implications for regulatory T cell therapies in autoimmunity and graft-versus-host disease.

Fulltext PDF

Indian Academy of Sciences (India)

2018-04-20

Apr 20, 2018 ... Science Academies' 98th Refresher Course in Experimental ... to 16 June 2018 for the benefit of faculty involved in teaching undergraduate and ... regulations include Refresher Courses in API scores for career advancement.

75 FR 20909 - Standards of Conduct for Transmission Providers

Science.gov (United States)

2010-04-22

... change in our treatment of G&T cooperatives. Therefore, we clarify that sales of power by generation and...), order on reh'g, Order No. 2003-A, FERC Stats. & Regs. ] 31,160, order on reh'g, Order No. 2003-B, FERC Stats. & Regs. ] 31,171 (2004), order on reh'g, Order No. 2003-C, FERC Stats. & Regs. ] 31,190 (2005...

xdamp Version 4: An IDL Based Data and Image Manipulation Program

International Nuclear Information System (INIS)

William P. Ballard

2002-01-01

The original DAMP (W t a Manipulation Program) was written by Mark Hedemann of Sandia National Laboratories and used the CA-DISSPLA(trademark) (available from Computer Associates International, Inc., Garden City, NY) graphics package as its engine. It was used to plot, modify, and otherwise manipulate the one-dimensional data waveforms (data vs. time) from a wide variety of accelerators. With the waning of CA-DISSPLA and the increasing popularity of Unix(reg s ign)-based workstations, a replacement was needed. This package uses the IDL(reg s ign) software, available from Research Systems Incorporated, a Xerox company, in Boulder, Colorado, as the engine, and creates a set of widgets to manipulate the data in a manner similar to the original DAMP and earlier versions of xdamp. IDL is currently supported on a wide variety of Unix platforms such as IBM(reg s ign) workstations, Hewlett Packard workstations, SUN(reg s ign) workstations, Microsoft(reg s ign) Windows(trademark) computers, Macintosh(reg s ign) computers and Digital Equipment Corporation VMS(reg s ign) and Alpha(reg s ign) systems. Thus, xdamp is portable across many platforms. We have verified operation, albeit with some minor IDL bugs, on personal computers using Windows 95 and Windows NT; IBM Unix platforms; DEC Alpha and VMS systems; HP 9000/700 series workstations; and Macintosh computers, both regular and PowerPC(trademark) versions. Version 4 is an update that removes some obsolete features and better supports very large arrays and Excel formatted data import

Predicting Summer Dryness Under a Warmer Climate: Modeling Land Surface Processes in the Midwestern United States

Science.gov (United States)

Winter, J. M.; Eltahir, E. A.

2009-12-01

One of the most significant impacts of climate change is the potential alteration of local hydrologic cycles over agriculturally productive areas. As the world’s food supply continues to be taxed by its burgeoning population, a greater percentage of arable land will need to be utilized and land currently producing food must become more efficient. This study seeks to quantify the effects of climate change on soil moisture in the American Midwest. A series of 24-year numerical experiments were conducted to assess the ability of Regional Climate Model Version 3 coupled to Integrated Biosphere Simulator (RegCM3-IBIS) and Biosphere-Atmosphere Transfer Scheme 1e (RegCM3-BATS1e) to simulate the observed hydroclimatology of the midwestern United States. Model results were evaluated using NASA Surface Radiation Budget, NASA Earth Radiation Budget Experiment, Illinois State Water Survey, Climate Research Unit Time Series 2.1, Global Soil Moisture Data Bank, and regional-scale estimations of evapotranspiration. The response of RegCM3-IBIS and RegCM3-BATS1e to a surrogate climate change scenario, a warming of 3oC at the boundaries and doubling of CO2, was explored. Precipitation increased significantly during the spring and summer in both RegCM3-IBIS and RegCM3-BATS1e, leading to additional runoff. In contrast, enhancement of evapotranspiration and shortwave radiation were modest. Soil moisture remained relatively unchanged in RegCM3-IBIS, while RegCM3-BATS1e exhibited some fall and winter wetting.

A paleolimnological perspective on industrial-era metal pollution in the central Andes, Peru.

Science.gov (United States)

Cooke, Colin A; Abbott, Mark B

2008-04-15

To date, few studies have investigated the environmental legacy associated with industrialization in the South American Andes. Here, we present an environmental archive of industrial pollution from (210)Pb-dated lake cores recovered from Laguna Chipian, located near the Cerro de Pasco metallurgical region and Laguna Pirhuacocha, located near the Morococha mining region and the La Oroya smelting complex. At Laguna Chipian, trace metal concentrations increase beginning ~1900 AD, coincident with the construction of the central Peruvian railway, and the rapid industrial development of the Cerro de Pasco region. Trace metal concentrations and fluxes peak during the 1950s before subsequently declining up-core (though remaining well above background levels). While Colonial mining and smelting operations are known to have occurred at Cerro de Pasco since at least 1630 AD, our sediment record preserves no associated metal deposition. Based on our (14)C and (210)Pb data, we suggest that this is due to a depositional hiatus, rather than a lack of regional Colonial pollution. At Laguna Pirhuacocha, industrial trace metal deposition first begins ~1925 AD, rapidly increasing after ~1950 AD and peaking during either the 1970s or 1990s. Trace metal concentrations from these lakes are comparable to some of the most polluted lakes in North America and Europe. There appears to be little diagenetic alteration of the trace metal record at either lake, the exception being arsenic (As) accumulation at Laguna Pirhuacocha. There, a correlation between As and the redox-sensitive element manganese (Mn) suggests that the sedimentary As burden is undergoing diagenetic migration towards the sediment-water interface. This mobility has contributed to surface sediment As concentrations in excess of 1100 microg g(-1). The results presented here chronicle a rapidly changing Andean environment, and highlight a need for future research in the rate and magnitude of atmospheric metal pollution.

A paleolimnological perspective on industrial-era metal pollution in the central Andes, Peru

International Nuclear Information System (INIS)

Cooke, Colin A.; Abbott, Mark B.

2008-01-01

To date, few studies have investigated the environmental legacy associated with industrialization in the South American Andes. Here, we present an environmental archive of industrial pollution from 210 Pb-dated lake cores recovered from Laguna Chipian, located near the Cerro de Pasco metallurgical region and Laguna Pirhuacocha, located near the Morococha mining region and the La Oroya smelting complex. At Laguna Chipian, trace metal concentrations increase beginning ∼ 1900 AD, coincident with the construction of the central Peruvian railway, and the rapid industrial development of the Cerro de Pasco region. Trace metal concentrations and fluxes peak during the 1950s before subsequently declining up-core (though remaining well above background levels). While Colonial mining and smelting operations are known to have occurred at Cerro de Pasco since at least 1630 AD, our sediment record preserves no associated metal deposition. Based on our 14 C and 210 Pb data, we suggest that this is due to a depositional hiatus, rather than a lack of regional Colonial pollution. At Laguna Pirhuacocha, industrial trace metal deposition first begins ∼ 1925 AD, rapidly increasing after ∼ 1950 AD and peaking during either the 1970s or 1990s. Trace metal concentrations from these lakes are comparable to some of the most polluted lakes in North America and Europe. There appears to be little diagenetic alteration of the trace metal record at either lake, the exception being arsenic (As) accumulation at Laguna Pirhuacocha. There, a correlation between As and the redox-sensitive element manganese (Mn) suggests that the sedimentary As burden is undergoing diagenetic migration towards the sediment-water interface. This mobility has contributed to surface sediment As concentrations in excess of 1100 μg g -1 . The results presented here chronicle a rapidly changing Andean environment, and highlight a need for future research in the rate and magnitude of atmospheric metal pollution

Environmental remediation 1991: ''Cleaning up the environment for the 21st Century''

International Nuclear Information System (INIS)

Wood, D.E.

1991-01-01

This report presents discussions given at a conference on environmental remediation, September 8--11, Pasco, Washington. Topics include: public confidence; education; in-situ remediation; Hanford tank operations; risk assessments; field experiences; standards; site characterization and monitoring; technology discussions; regulatory issues; compliance; and the UMTRA project. Individual projects are processed separately for the data bases

Environmental remediation 1991: ``Cleaning up the environment for the 21st Century``. Proceedings

Energy Technology Data Exchange (ETDEWEB)

Wood, D.E. [ed.] [Westinghouse Hanford Co., Richland, WA (United States)

1991-12-31

This report presents discussions given at a conference on environmental remediation, September 8--11, Pasco, Washington. Topics include: public confidence; education; in-situ remediation; Hanford tank operations; risk assessments; field experiences; standards; site characterization and monitoring; technology discussions; regulatory issues; compliance; and the UMTRA project. Individual projects are processed separately for the data bases.

Resonance – Journal of Science Education | News

Indian Academy of Sciences (India)

Science Academies' Refresher Course on Theoretical Structural Geology, Crystallography, Mineralogy, Thermodynamics, Experimental Petrology and Theoretical Geophysics · More Details Abstract Fulltext PDF. pp 816-816 Information and Announcements. Science Academies' Refresher Course in Foundations of ...

Columbia River pathway report: phase I of the Hanford Environmental Dose Reconstruction Project

Energy Technology Data Exchange (ETDEWEB)

1991-07-01

This report summarizes the river-pathway portion of the first phase of the Hanford Environmental Dose Reconstruction (HEDR) Project. The HEDR Project is estimating radiation doses that could have been received by the public from the Department of Energy's Hanford Site, in southeastern Washington State. Phase 1 of the river-pathway dose reconstruction effort sought to determine whether dose estimates could be calculated for populations in the area from above the Hanford Site at Priest Rapids Dam to below the site at McNary Dam from January 1964 to December 1966. Of the potential sources of radionuclides from the river, fish consumption was the most important. Doses from drinking water were lower at Pasco than at Richland and lower at Kennewick than at Pasco. The median values of preliminary dose estimates calculated by HEDR are similar to independent, previously published estimates of average doses to Richland residents. Later phases of the HEDR Project will address dose estimates for periods other than 1964--1966 and for populations downstream of McNary Dam. 17 refs., 19 figs., 1 tab.

Interim housing conditions profile, Benton and Franklin Counties, Washington: BWIP Repository Project: Working draft

International Nuclear Information System (INIS)

Bolton, P.A.

1987-11-01

This report describes the housing stock and its availability in Benton and Franklin counties. Depending on the specific measures, data are presented for the entire MSA, for Benton and Franklin counties separately, for incorporated and unincorporated areas within the counties, and for specific incorporated areas. The most detailed data are available for the two counties and for the major cities of Kennewick and Richland in Benton County and Pasco in Franklin County. In 1986, 64 percent of the population of Benton County and 66 percent of the housing units were in Kennewick and Richland. Seventy-three percent of the population and 75 percent of the housing were in the incorporated area of Benton County. In Franklin County, Pasco accounted for 52 percent of the county's 1986 population and 57 percent of its housing. Fifty-nine percent of the population and 63 percent of the housing were in the incorporated areas of Franklin County. More detailed data are needed to fully describe the housing conditions in the jurisdictions described here. 13 refs., 9 tabs

Columbia River pathway report

International Nuclear Information System (INIS)

1991-07-01

This report summarizes the river-pathway portion of the first phase of the Hanford Environmental Dose Reconstruction (HEDR) Project. The HEDR Project is estimating radiation doses that could have been received by the public from the Department of Energy's Hanford Site, in southeastern Washington State. Phase 1 of the river-pathway dose reconstruction effort sought to determine whether dose estimates could be calculated for populations in the area from above the Hanford Site at Priest Rapids Dam to below the site at McNary Dam from January 1964 to December 1966. Of the potential sources of radionuclides from the river, fish consumption was the most important. Doses from drinking water were lower at Pasco than at Richland and lower at Kennewick than at Pasco. The median values of preliminary dose estimates calculated by HEDR are similar to independent, previously published estimates of average doses to Richland residents. Later phases of the HEDR Project will address dose estimates for periods other than 1964--1966 and for populations downstream of McNary Dam. 17 refs., 19 figs., 1 tab

Effect of just-in-time simulation training on tracheal intubation procedure safety in the pediatric intensive care unit.

Science.gov (United States)

Nishisaki, Akira; Donoghue, Aaron J; Colborn, Shawn; Watson, Christine; Meyer, Andrew; Brown, Calvin A; Helfaer, Mark A; Walls, Ron M; Nadkarni, Vinay M

2010-07-01

Tracheal intubation-associated events (TIAEs) are common (20%) and life threatening (4%) in pediatric intensive care units. Physician trainees are required to learn tracheal intubation during intensive care unit rotations. The authors hypothesized that "just-in-time" simulation-based intubation refresher training would improve resident participation, success, and decrease TIAEs. For 14 months, one of two on-call residents, nurses, and respiratory therapists received 20-min multidisciplinary simulation-based tracheal intubation training and 10-min resident skill refresher training at the beginning of their on-call period in addition to routine residency education. The rate of first attempt and overall success between refresher-trained and concurrent non-refresher-trained residents (controls) during the intervention phase was compared. The incidence of TIAEs between preintervention and intervention phase was also compared. Four hundred one consecutive primary orotracheal intubations were evaluated: 220 preintervention and 181 intervention. During intervention phase, neither first-attempt success nor overall success rate differed between refresher-trained residents versus concurrent non-refresher-trained residents: 20 of 40 (50%) versus 15 of 24 (62.5%), P = 0.44 and 23 of 40 (57.5%) versus 18 of 24 (75.0%), P = 0.19, respectively. The resident's first attempt and overall success rate did not differ between preintervention and intervention phases. The incidence of TIAE during preintervention and intervention phases was similar: 22.0% preintervention versus 19.9% intervention, P = 0.62, whereas resident participation increased from 20.9% preintervention to 35.4% intervention, P = 0.002. Resident participation continued to be associated with TIAE even after adjusting for the phase and difficult airway condition: odds ratio 2.22 (95% CI 1.28-3.87, P = 0.005). Brief just-in-time multidisciplinary simulation-based intubation refresher training did not improve the resident

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Indian Academy of Sciences (India)

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Ethics. 95. 165 Chemical Utilisation of CO2. A Challenge for the Sustainable World. Dinesh Jagadeesan, Bhaskar Joshi and Prashant. Parameswaran. Information & Announcements. Science Academies' Seventieth Refresher Course in. Experimental Physics. Science Academies' Refresher Course in Experimental. Physics.

Using JPSS VIIRS Fire Radiative Power Data to Forecast Biomass Burning Emissions and Smoke Transport by the High Resolution Rapid Refresh Model

Science.gov (United States)

Ahmadov, R.; Grell, G. A.; James, E.; Alexander, C.; Stewart, J.; Benjamin, S.; McKeen, S. A.; Csiszar, I. A.; Tsidulko, M.; Pierce, R. B.; Pereira, G.; Freitas, S. R.; Goldberg, M.

2017-12-01

We present a new real-time smoke modeling system, the High Resolution Rapid Refresh coupled with smoke (HRRR-Smoke), to simulate biomass burning (BB) emissions, plume rise and smoke transport in real time. The HRRR is the NOAA Earth System Research Laboratory's 3km grid spacing version of the Weather Research and Forecasting (WRF) model used for weather forecasting. Here we make use of WRF-Chem (the WRF model coupled with chemistry) and simulate fine particulate matter (smoke) emissions emitted by BB. The HRRR-Smoke modeling system ingests fire radiative power (FRP) data from the Visible Infrared Imaging Radiometer Suite (VIIRS) sensor on the Suomi National Polar-orbiting Partnership (S-NPP) satellite to calculate BB emissions. The FRP product is based on processing 750m resolution "M" bands. The algorithms for fire detection and FRP retrieval are consistent with those used to generate the MODIS fire detection data. For the purpose of ingesting VIIRS fire data into the HRRR-Smoke model, text files are generated to provide the location and detection confidence of fire pixels, as well as FRP. The VIIRS FRP data from the text files are processed and remapped over the HRRR-Smoke model domains. We process the FRP data to calculate BB emissions (smoldering part) and fire size for the model input. In addition, HRRR-Smoke uses the FRP data to simulate the injection height for the flaming emissions using concurrently simulated meteorological fields by the model. Currently, there are two 3km resolution domains covering the contiguous US and Alaska which are used to simulate smoke in real time. In our presentation, we focus on the CONUS domain. HRRR-Smoke is initialized 4 times per day to forecast smoke concentrations for the next 36 hours. The VIIRS FRP data, as well as near-surface and vertically integrated smoke mass concentrations are visualized for every forecast hour. These plots are provided to the public via the HRRR-Smoke web-page: https

Minutes of the Tank Waste Science Panel meeting, November 11--13, 1991. Hanford Tank Safety Project

Energy Technology Data Exchange (ETDEWEB)

Strachan, D.M. [comp.

1992-04-01

The sixth meeting of the Tank Waste Science Panel was held November 11--13, 1991, in Pasco and Richland, Washington. Participating scientists presented the results of recent work on various aspects of issues relating to the generation and release of gases from Tank 241-SY-101 and the presence of ferrocyanide in other tanks at Hanford. Results are discussed.

Minutes of the Tank Waste Science Panel meeting, November 11--13, 1991

Energy Technology Data Exchange (ETDEWEB)

Strachan, D.M. (comp.)

1992-04-01

The sixth meeting of the Tank Waste Science Panel was held November 11--13, 1991, in Pasco and Richland, Washington. Participating scientists presented the results of recent work on various aspects of issues relating to the generation and release of gases from Tank 241-SY-101 and the presence of ferrocyanide in other tanks at Hanford. Results are discussed.

Minutes of the Tank Waste Science Panel meeting, November 11--13, 1991

International Nuclear Information System (INIS)

Strachan, D.M.

1992-04-01

The sixth meeting of the Tank Waste Science Panel was held November 11--13, 1991, in Pasco and Richland, Washington. Participating scientists presented the results of recent work on various aspects of issues relating to the generation and release of gases from Tank 241-SY-101 and the presence of ferrocyanide in other tanks at Hanford. Results are discussed

Affordances of Instrumentation in General Chemistry Laboratories

Science.gov (United States)

Sherman, Kristin Mary Daniels

2010-01-01

The purpose of this study is to find out what students in the first chemistry course at the undergraduate level (general chemistry for science majors) know about the affordances of instrumentation used in the general chemistry laboratory and how their knowledge develops over time. Overall, students see the PASCO(TM) system as a useful and accurate…

Measuring the Specific Heat of Metals by Cooling

Science.gov (United States)

Dittrich, William; Minkin, Leonid; Shapovalov, Alexander S.

2010-01-01

Three in one? Yes, three standard undergraduate thermodynamics experiments in one, not an oval can of lubricating oil. Previously it has been shown that the PASCO scientific apparatus for measuring coefficients of thermal expansion of metals can also be used to illustrate Newton's law of cooling in the same experiment. Now it will be shown that by…

2. Home 3. Journals 4. Resonance–Journal of Science Education 5 ...

Indian Academy of Sciences (India)

(Illustration: Subhankar Biswas). Front Cover. 1. Science Smiles. Ayan Guha. 5. Back Cover. Science Academies' Refresher Course in. Experimental Physics. Science Academies' Sixtieth Refresher. Course in Experimental Physics. Information & Announcements. 97. 98. Classics. Quantization of an. Ideal Monoatomic Gas.

Fulltext PDF

Indian Academy of Sciences (India)

Information & Announcements. Experiments for Tomorrow – XXXV Refresher Course in Experimental Physics. Science Academies' Summer Research Fellowship. Programme for Students and Teachers – 2012. (SRFP-2012). Science Academies' Refresher Course on Paradigms and Applications of Pattern Recognition in ...

Survival from breast, colon, lung, ovarian and rectal cancer by geographical remoteness in New South Wales, Australia, 2000-2008.

Science.gov (United States)

Chen, Tina Y T; Morrell, Stephen; Thomson, Wendy; Baker, Deborah F; Walton, Richard; Aranda, Sanchia; Currow, David C

2015-02-01

This study aims to compare survival from breast, colon, lung, ovarian and rectal cancer by geographical remoteness in New South Wales (NSW). Retrospective population-wide registry study. NSW, Australia. A total of 107 060 NSW residents, who were diagnosed with any of the five cancers between 01 January 2000 and 31 December 2008. Kaplan-Meier survival curves and proportional hazards regression were used to compare survival by geographical remoteness of residence at diagnosis, controlling for gender, age and extent of disease at diagnosis. Remoteness was classified using standard definitions: major city, inner regional (InnReg), outer regional (OutReg) and remote (including very remote). Significant differences in survival (likelihood of death) were identified in all five cancers: breast (adjusted hazard ratio(HR) = 1.22 (95% confidence interval (CI), 1.001-1.48) in regionalised and HR = 1.30 (1.02-1.64) in metastatic disease for OutReg areas); colon (HR = 1.14 (1.01-1.29) for OutReg areas in metastatic disease); lung (HR range = 1.08-1.35 (1.01-1.48) for most non-metropolitan areas in all stages of disease excepting regionalised); ovarian (HR = 1.32 (1.06-1.65) for OutReg areas in metastatic disease, HR = 1.40 (1.04-1.90) for InnReg areas and HR = 1.68 (1.02-2.77) for OutReg areas in unknown stage of disease) and rectal (HR = 1.37 (1.05-1.78) for OutReg areas in localised and HR = 1.14 (1.002-1.30) for InnReg areas in regionalised disease). Where significant differences were found, major cities tended to show the best survival, whereas OutReg areas tended to show the worst. Although no definitive interpretation could be made regarding remote areas due to small patient numbers, their survival appeared relatively favourable. Reasons that contribute to the differences observed and the disparate results between cancer types need to be further explored in order to facilitate targeted solutions in reducing survival inequality between NSW

Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths

Science.gov (United States)

Coomes, Stephanie M.; Kannan, Yashaswini; Entwistle, Lewis J.; Perez-Lloret, Jimena; Czieso, Stephanie

2017-01-01

Immunity to intestinal helminth infections requires the rapid activation of T helper 2 cells (Th2 cells). However, simultaneous expansion of CD4+Foxp3+ regulatory T cells (T reg cells) impedes protective responses, resulting in chronic infections. The ratio between T reg and effector T cells can therefore determine the outcome of infection. The redifferentiation of T reg cells into Th cells has been identified in hyperinflammatory diseases. In this study, we asked whether ex–T reg Th2 cells develop and contribute to type-2 immunity. Using multigene reporter and fate-reporter systems, we demonstrate that a significant proportion of Th2 cells derive from Foxp3+ cells after Heligmosomoides polygyrus infection and airway allergy. Ex-Foxp3 Th2 cells exhibit characteristic Th2 effector functions and provide immunity to H. polygyrus. Through selective deletion of Il4ra on Foxp3+ cells, we further demonstrate IL-4 is required for the development of ex-Foxp3 Th2 cells. Collectively, our findings indicate that converting T reg cells into Th2 cells could concomitantly enhance Th2 cells and limit T reg cell–mediated suppression. PMID:28507062

Flt3/Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis

Directory of Open Access Journals (Sweden)

Jing-Wei Mao

2014-01-01

Full Text Available The immunoregulation between dendritic cells (DCs and regulatory T cells (T-regs plays an important role in the pathogenesis of ulcerative colitis (UC. Recent research showed that Fms-like tyrosine kinase 3 (Flt3 and Flt3 ligand (Flt3L were involved in the process of DCs regulating T-regs. The DSS-induced colitis model is widely used because of its simplicity and many similarities with human UC. In this study, we observe the disease activity index (DAI and histological scoring, detect the amounts of DCs and T-regs and expression of Flt3/Flt3L, and investigate Flt3/Flt3L participating in the process of DCs regulating T-regs in DSS-induced colitis. Our findings suggest that the reduction of Flt3 and Flt3L expression may possibly induce colonic immunoregulatory imbalance between CD103+MHCII+DCs and CD4+CD25+FoxP3+T-regs in DSS-induced colitis. Flt3/Flt3L participates in the process of regulating DCS and T-regs in the pathogenesis of UC, at least, in the acute stage of this disease.

TOXPERT: An Expert System for Risk Assessment

Science.gov (United States)

Soto, R. J.; Osimitz, T. G.; Oleson, A.

1988-01-01

TOXPERT is an artificial intelligence based system used to model product safety, toxicology (TOX) and regulatory (REG) decision processes. An expert system shell uses backward chaining rule control to link “marketing approval” goals to the type of product, REG agency, exposure conditions and TOX. Marketing risks are primarily a function of the TOX, hazards and exposure potential. The method employed differentiates between REG requirements in goal seeking control for various types of products. This is accomplished by controlling rule execution by defining frames for each REG agency. In addition, TOXPERT produces classifications of TOX ratings and suggested product labeling. This production rule system uses principles of TOX, REGs, corporate guidelines and internal “rules of thumb.” TOXPERT acts as an advisor for this narrow domain. Advantages are that it can make routine decisions freeing professional's time for more complex problem solving, provide backup and training.

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Indian Academy of Sciences (India)

IAS Admin

Science Academies' Refresher Course in Experimental. Physics. Science Academies' Refresher Course in Developmental. Biology. 756. BOOK REVIEWS. 748 The Age of Extinction. Prasanna Venkhatesh V. 750 Prevent or Perish. Prasanna Venkhatesh V. 753 Hope for Animals. Prasanna Venkhatesh V. DEPARTMENTS.

75 FR 21508 - Health and Human Services Acquisition Regulation; Corrections

Science.gov (United States)

2010-04-26

..., Federal appropriations law, and green purchasing training requirements, including completion of refresher... law, and green purchasing training requirements, including completion of refresher training. If the... defined in FAR 17.103, is limited to individual acquisitions where the full estimated cancellation ceiling...

Resonance journal of science education

Indian Academy of Sciences (India)

IAS Admin

Refresher Course on Mountain Hydrology and. Climate Change. Science Academies' Seventy-Fifth Refresher Course in Experimental Physics. Information & Announcements. 106. 105. 108. Classics. Are we Utilizing our. Water Resources. Wisely? B P Radhakrishna. General Editorial on. Publication Ethics. 1. 93. 71.

32 CFR 632.6 - Administrative instructions.

Science.gov (United States)

2010-07-01

... defense techniques. (ii) MP club. (iii) Individual chemical aerosol irritant projectors. (iv) Their assigned firearms. (b) Commanders will also— (1) Provide periodic refresher training to ensure continued... guards to receive instructions regarding use of force. (Give periodic refresher training to ensure...

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Indian Academy of Sciences (India)

Research Scholar, Department of Chemistry ... The broad aim of the Refresher Course is to help motivate teachers to improve and refresh their teaching methodology in the above topics as well as create interest in applying these topics to the ...

Resonance

Indian Academy of Sciences (India)

Administrator

Refresher Course in. Experimental Physics. Refresher Course on. Advanced in Biophysics. IISc Young Science. Fellowship Programme. Inside Back Cover. Flowering Trees. (Credit: K Sankara Rao,IISc,. Bangalore). 97. 83. Classics. REFLECTIONS. 71 Integrative Microbiology – The Third Golden Age. Moselio Schaechter.

Die reg op lewe

Directory of Open Access Journals (Sweden)

J.M. Vorster

2002-08-01

Full Text Available The right to life This article deals with the practical application of the fundamental right to life with special focus on abortion, capital punishment and euthanasia. From a Christian ethical perspective and the biblical principle of life it is argued that the practice of abortion, capital punishment and euthanasia cannot be justified for various reasons. Christians should therefore consider other ways to deal with issues like unwanted pregnancies and suffering. Regarding serious crime, punitive measures other than capital punishment ought to be considered because the practice of capital punishment can be misused by the state and can lead to the abuse of power. Capital punishment is also detrimental to the development of a culture of respect for life in society at large.

Studies in Rheoencephalography (REG)

Science.gov (United States)

2010-04-01

Rheoencephalography and plethysmographic methods. Excerpta, Amsterdam. 1969. 25. Yarullin HH. Clinical rheoencephalography. Medicina , Leningrad. 1967...in Russian). Medicina , Leningrad. 1975. 32. Bodo M, Racz J, Ilias L, Pasztor A, Vajda J, Weinstein GB, Pasztor E, Moskalenko YE

32 CFR 323.4 - Responsibilities.

Science.gov (United States)

2010-07-01

... Agency. (1) The Staff Director, Corporate Communications, DLA Support Services (DSS-C) will: (i... upon assignment. Refresher training will be provided annually or more frequently if conditions warrant... military members upon assignment. Refresher training will be provided annually or more frequently if...

Climate change effects on shallow lakes: design and preliminary results of a cross-European climate gradient mesocosm experiment

Czech Academy of Sciences Publication Activity Database

Landkildehus, F.; Søndergaard, M.; Beklioglu, M.; Adrian, R.; Angeler, D.G.; Hejzlar, Josef; Papastergiadou, E.; Zingel, P.; Çakiroğlu, A.I.; Scharfenberger, U.; Drakare, S.; Nõges, T.; Šorf, Michal; Stefanidis, K.; Tavşanoğlu, Ü.N.; Trigal, C.; Mahdy, A.; Papadaki, C.; Tuvikene, L.; Larsen, S.E.; Kernan, M.; Jeppesen, E.

2014-01-01

Roč. 63, č. 2 (2014), s. 71-89 ISSN 1736-602X EU Projects: European Commission(XE) 244121 - REFRESH Institutional support: RVO:60077344 Keywords : climate change * nutrient enrichment * water level effects * macroecology * REFRESH project * macrophytes * metabolism Subject RIV: DA - Hydrology ; Limnology

2. Home 3. Journals 4. Resonance–Journal of Science Education 5 ...

Indian Academy of Sciences (India)

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Day with School. Children. Vishwesha Guttal. 254. Classics. Predictability: Does the Flap of a Butterfly's Wings in. Brazil Set off a Tornado in Texas? Edward U Lorenz. Science Academies' Refresher Course in Quantum. Mechanics. Science Academies' Refresher Course in Mathematics. Information & Announcements. 278.

Resonance – Journal of Science Education | News

Indian Academy of Sciences (India)

Science Academies' Refresher Course on Paradigms and Applications of Pattern Recognition in Image Processing and Computer Vision · More Details Fulltext PDF. pp 1101-1101 Information and Announcements. Science Academies' Refresher Course on Cell and Molecular Biology Techniques · More Details Fulltext PDF.

xdamp Version 4 An IDL Based Data and Image Manipulation Program

CERN Document Server

William-Ballar, P

2002-01-01

The original DAMP (W t a Manipulation Program) was written by Mark Hedemann of Sandia National Laboratories and used the CA-DISSPLA(trademark) (available from Computer Associates International, Inc., Garden City, NY) graphics package as its engine. It was used to plot, modify, and otherwise manipulate the one-dimensional data waveforms (data vs. time) from a wide variety of accelerators. With the waning of CA-DISSPLA and the increasing popularity of Unix(reg sub s ign)-based workstations, a replacement was needed. This package uses the IDL(reg sub s ign) software, available from Research Systems Incorporated, a Xerox company, in Boulder, Colorado, as the engine, and creates a set of widgets to manipulate the data in a manner similar to the original DAMP and earlier versions of xdamp. IDL is currently supported on a wide variety of Unix platforms such as IBM(reg sub s ign) workstations, Hewlett Packard workstations, SUN(reg sub s ign) workstations, Microsoft(reg sub s ign) Windows(trademark) computers, Macinto...

Safety assessment of immunomodulatory biologics: the promise and challenges of regulatory T-cell modulation.

Science.gov (United States)

Ponce, Rafael A

2011-01-01

Regulatory T-cell (T(reg)) modulation is developing as an important therapeutic opportunity for the treatment of a number of important diseases, including cancer, autoimmunity, infection, and organ transplant rejection. However, as demonstrated with IL-2 and TGN-1412, our understanding of the complex immunological interactions that occur with T(reg) modulation in both non-clinical models and in patients remains limited and appears highly contextual. This lack of understanding will challenge our ability to identify the patient population who might derive the highest benefit from T(reg) modulation and creates special challenges as we transition these therapeutics from non-clinical models into humans. Thus, in vivo testing in the most representative animal model systems, with careful progress in the clinic, will remain critical in developing therapeutics targeting T(reg) and understanding their clinical utility. Moreover, toxicology models can inform some of the potential liabilities associated with T(reg) modulation, but not all, suggesting a continued need to explore and validate predictive models.

Naturally occurring CD4+ CD25+ FOXP3+ T-regulatory cells are increased in chronic myeloid leukemia patients not in complete cytogenetic remission and can be immunosuppressive.

Science.gov (United States)

Rojas, Jose M; Wang, Lihui; Owen, Sally; Knight, Katy; Watmough, Sarah J; Clark, Richard E

2010-12-01

Clinical presentation of chronic myeloid leukemia (CML) requires not only the deregulated tyrosine kinase BCR-ABL, but also the failure of an immune response against BCR-ABL-expressing cells. T-cell responses against BCR-ABL and other antigens are well-described, but their relevance to the in vivo control of CML is unclear. The suppressive role of naturally occurring T regulatory (T-reg) cells in antitumor immunity is well-established, although little is known about their role in modulating the T-cell response to BCR-ABL. Naturally occurring T-reg cells were characterized and quantified by flow cytometry in 39 CML patients and 10 healthy donors. Their function was studied by observing their effect on responses to purified protein derivative, a recall antigen, and on the response of an autologous T-cell line recognizing BCR-ABL. T-reg cells were CD4(+), CD25(+), FOXP3(+), CD127(low), and CD62L(high). T-reg numbers in patients in complete cytogenetic remission were significantly lower than in patients not in complete cytogenetic remission (p T-reg cell depletion using anti-CD25 selection enhanced proliferative responses to purified protein derivative. Furthermore, the interferon-γ and/or granzyme-B production of effector cells specific for viral peptides or a BCR-ABL HLA-A3-restricted peptide was inhibited when autologous T-reg cells were present. Taken together, these data suggest a role for T-reg cells in limiting immune responses in CML patients and this may include immune responses to BCR-ABL. The increased frequency of T-reg cells in patients with high levels of BCR-ABL transcripts indicates that an immune mechanism may be important in the control of CML. Copyright © 2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.

Mixed-Matrix Membranes for CO2 and H2 Gas Separations Using Metal-Organic Framework and Mesoporus Hybrid Silicas

International Nuclear Information System (INIS)

Musselman, Inga; Balkus, Kenneth Jr.; Ferraris, John

2009-01-01

In this work, we have investigated the separation performance of polymer-based mixed-matrix membranes containing metal-organic frameworks and mesoporous hybrid silicas. The MOF/Matrimid(reg s ign) and MOP-18/Matrimid(reg s ign) membranes exhibited improved dispersion and mechanical strength that allowed high additive loadings with reduced aggregation, as is the case of the 80 wt% MOP-18/Matrimid(reg s ign) and the 80% (w/w) Cu-MOF/Matrimid(reg s ign) membranes. Membranes with up to 60% (w/w) ZIF-8 content exhibited similar mechanical strength and improved dispersion. The H 2 /CO 2 separation properties of MOF/Matrimid(reg s ign) mixed-matrix membranes was improved by either keeping the selectivity constant and increasing the permeability (MOF-5, Cu-MOF) or by improving both selectivity and permeability (ZIF-8). In the case of MOF-5/Matrimid(reg s ign) mixed-matrix membranes, the H 2 /CO 2 selectivity was kept at 2.6 and the H 2 permeability increased from 24.4 to 53.8 Barrers. For the Cu-MOF/Matrimid(reg s ign) mixed-matrix membranes, the H 2 /CO 2 selectivity was kept at 2.05 and the H 2 permeability increased from 17.1 to 158 Barrers. These two materials introduced porosity and uniform paths that enhanced the gas transport in the membranes. When ZIF-8/Matrimid(reg s ign) mixed-matrix membranes were studied, the H 2 /CO 2 selectivity increased from 2.9 to 4.4 and the permeability of H 2 increased from 26.5 to 35.8 Barrers. The increased H 2 /CO 2 selectivity in ZIF-8/Matrimid(reg s ign) membranes was explained by the sieving effect introduced by the ZIF-8 crystals (pore window 0.34 nm) that restricted the transport of molecules larger than H 2 . Materials with microporous and/or mesoporous cavities like carbon aerogel composites with zeolite A and zeolite Y, and membranes containing mesoporous ZSM-5 showed sieving effects for small molecules (e.g. H 2 and CO 2 ), however, the membranes were most selective for CO 2 due to the strong interaction of the zeolites with

CVE and the Corporate Market: A Case Study of the Experience of Warwick Business School.

Science.gov (United States)

Antonazzi, Leoni

1998-01-01

Reviews the promotion and practice of continuing vocational education (CVE) at Warwick Business School (United Kingdom) for executives within the corporate sector. Highlights include relationship management, brand building, an MBA (Masters in Business Education) refresher course, a strategic management refresher course, and future developments.…

Untitled

African Journals Online (AJOL)

Elamin

Krüger B, Fischereder M, Jauch KW, Graeb C,. Hoffmann U, Böger CA, Banas B, Obed A. Schlitt HJ,. Krämer BK. Five-year follow-up after late conversion from calcineurin inhibitors to sirolimus in patients with chronic renal allograff dysfunction. Transplant Proc. 2007 Mar,39(2):518-21. 54. Schena FP, Pascoe MD, Albertu J, ...

Trachypholini, Colydiidarum nove tribus

NARCIS (Netherlands)

Grouvelle, A.

1911-01-01

Le genre Chorites a été établi par Pascoe, en 1862, Journ. of Ent. I, p. 114, pour un Colydien de Bornéo, C. aspis, dont l’aspect lui semblait exceptionnel. En 1866, Journ. of Ent. II, p. 139, le même auteur ajouta deux espèces nouvelles à ce genre : C. lotus Singapore, C. oblongus Macassar et,

Células T regulatórias naturais (T REGS em doenças reumáticas Natural regulatory T cells in rheumatic diseases

Directory of Open Access Journals (Sweden)

Wilson de Melo Cruvinel

2008-12-01

Full Text Available O sistema imune sadio deve manter o balanço entre a capacidade de responder a agentes infecciosos e de sustentar a autotolerância. A ausência de resposta adequada submete o indivíduo aos efeitos deletérios da invasão por patógenos, ao passo que o sistema respondendo de modo exacerbado pode gerar respostas inflamatórias prejudiciais. Acreditava-se que os mecanismos de deleção clonal e anergia fossem os mecanismos essenciais no controle de clones de linfócitos T auto-reativos. Apesar das evidências funcionais a favor da existência de células T supressoras, por muitos anos a imunologia falhou em identificar suas características fenotípicas e confirmar sua existência, motivo pelo qual o tema passou por longo período de descrédito. A recente demonstração de diferentes fenótipos de células, agora chamadas células T regulatórias, reintroduziu o paradigma de que a auto-reatividade é ativamente regulada também por subtipos particulares de linfócitos. Este tema é de grande interesse contemporâneo e a literatura está repleta de estudos descrevendo novos subtipos de células regulatórias, bem como a função, o fenótipo e a freqüência em condições fisiológicas e patológicas. Nesse universo, destaca-se o subtipo mais importante de células com função imunorregulatória, conhecido como células T regulatórias naturais (T REGS. Representando cerca de 5% dos linfócitos T CD4 do sangue periférico, são células caracterizadas pela expressão constitutiva das moléculas FOXP3, GITR, CTLA-4 e altos níveis de CD25. As alterações deletérias nesta população resultam o desencadeamento de doenças auto-imunes em camundongos, muito semelhantes às doenças auto-imunes humanas. A presente revisão aborda os conhecimentos básicos sobre as T REGS e seu estudo em doenças reumáticas de classificação auto-imune, abrindo perspectivas para o entendimento dos mecanismos de regulação periférica e sobre a fisiopatologia

Resonance – Journal of Science Education | News

Indian Academy of Sciences (India)

pp 93-93 Information and Announcements. Refresher Course on Lasers and Applications in Chemical Processes · More Details Fulltext PDF. pp 94-94 Information and Announcements. Refresher Course in Mathematics · More Details Fulltext PDF. pp 97-97 Flowering Trees. Moringa oleifera · More Details Fulltext PDF.

Resonance – Journal of Science Education | News

Indian Academy of Sciences (India)

Quantization of an Ideal Monoatomic Gas · E Fermi · More Details Fulltext PDF. pp 97-97 Information and Announcements. Science Academies' Refresher Course in Experimental Physics · More Details Fulltext PDF. pp 98-98 Information and Announcements. Science Academies' Sixtieth Refresher Course in Experimental ...

Army Communicator. Volume 35, Number 3, Fall 2010

Science.gov (United States)

2010-01-01

Malaysia ...Center. IT contractors were also an integral part of the task force design and specifically for completing the sizable DELL tech refresh contract...cost avoidance alone from completion of the DELL tech refresh project ahead of schedule and implementation of COOP and CEN- TRIX networks.

CPR: Infant

Medline Plus

Full Text Available ... LIFEGUARDING Refresher Putting It All Together: CPR—Infant (1:52) Refresher videos only utilize this player QUICK LINKS Home RedCross.org Purchase Course Materials Shop Our Store Contact Us Privacy Policy Terms and Conditions All rights reserved. 2011 American National Red Cross.

Q46 Technology Refreshment Assessment

Science.gov (United States)

Garcia-Burgos, Axel A.

2010-01-01

This document reviews the accomplishments of the author during an internship. During this internship, the author was assigned to the End User Services Office, which coordinates and oversees a wide selection of information technologies that enhance the productivity of the workforce at NASA Kennedy Space Center. During the internship the author performed an assessment of the work of the Outsourcing Desktop Initiative for NASA (ODIN) contract.

A refresher course in mathematics

CERN Document Server

Camm, F J

2003-01-01

Readers wishing to renew and extend their acquaintance with a variety of branches of mathematics will find this volume a practical companion. Geared toward those who already possess some familiarity with its subjects, the easy-to-follow explanations and straightforward tone make this book highly accessible. The contents are arranged logically and in order of difficulty: fractions, decimals, square and cube root, the metric system, algebra, quadratic and cubic equations, graphs, and the calculus are among the topics. Explanations of mathematical principles are followed by worked examples, and t

Informationized Expo Shanghai Refreshes History

Institute of Scientific and Technical Information of China (English)

Rose Yan

2010-01-01

@@ On May 1, the remarkable World Expo Shanghai was lifting its curtain.Among many highlights of Expo Shanghai is the informationization: Expo Shanghai on-line is the display of World Expo through internet for the first time in the history; With the pioneering "mobile phone entrance tickets", the audience just swipe your mobile phone at the corresponding instrument and then can enter the EXPO garden; the application of 4G technology would also exhibit a brilliant outlook of the future communication industry for the people.

Refresher Course on Animal Behaviour

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 9; Issue 7. Referesher Course on Animal Behaviour. Information and Announcements Volume 9 Issue 7 July 2004 pp 103-103. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/009/07/0103-0103 ...

Kalnapilis will refresh its brand

Index Scriptorium Estoniae

2004-01-01

Leedu õlletööstuse Kalnapilis-Tauras Groupi turundusjuht Stig Mose Henriksen kavandatavatest muutustest ettevõtte turundusstrateegias, tootearendusest ja brändi maine parandamisest, oma eesmärkidest ettevõttes

Refresher Course on Earth Sciences

Indian Academy of Sciences (India)

Information and Announcements ... Introduction: Geoscience education in India is in the throes of a serious crisis and any paradigm ... considerations: geology needs to be taught as an earth system science, linked with cognate ... viable and employment-generating management of natural resources: the global trend of.

Serum immunoreactive erythropoietin in high altitude natives with and without excessive erythrocytosis.

Science.gov (United States)

León-Velarde, F; Monge, C C; Vidal, A; Carcagno, M; Criscuolo, M; Bozzini, C E

1991-05-01

We report the estimation of blood hemoglobin (Hb), arterial blood oxygen saturation (SaO2), and serum immunoreactive erythropoietin (siEPO) in a group of Peruvian workers residing in Cerro de Pasco at 4300 m showing "excessive erythrocytosis" (EE, Monge's disease, chronic mountain sickness). These estimates were compared with those of humans residing either in Cerro de Pasco and showing "normal erythrocytosis" (NE) or in Lima (sea level, SL) to determine whether Hb and SaO2 are related to siEPO in high altitude (HA) natives with NE or EE. The three parameters showed statistically significant differences between HA and SL groups--the values in SL being lower. Significant differences were also found between NE and EE groups in Hb and SaO2. There was no statistical difference in siEPo between the two groups. The results indicate, therefore, that HA residents who develop EE are not distinguishable from residents who develop NE on the basis of estimates of siEPO. As a result, siEPO and Hb do not show a dose-response relationship in HA residents, and variation in EPO does not explain the striking variation in Hb at high altitudes.

Investigations on passive containment cooling; Untersuchungen zur passiven Containmentkuehlung

Energy Technology Data Exchange (ETDEWEB)

Knebel, J.U.; Cheng, X.; Neitzel, H.J.; Erbacher, F.J. [Forschungszentrum Karlsruhe GmbH Technik und Umwelt (Germany). Inst. fuer Angewandte Thermo- und Fluiddynamik; Hofmann, F. [Forschungszentrum Karlsruhe GmbH Technik und Umwelt (Germany). Projekt Nukleare Sicherheitsforschung

1997-12-31

The composite containment design for advanced LWRs that has been examined under the PASCO project is a promising design concept for purely passive decay heat removal after a severe accident. The passive cooling processes applied are natural convection and radiative heat transfer. Heat transfer through the latter process removes at an emission coefficient of 0.9 about 50% of the total heat removed via the steel containment, and thus is an essential factor. The heat transferring surfaces must have a high emission coefficient. The sump cooling concept examined under the SUCO project achieves a steady, natural convection-driven flow from the heat source to the heat sink. (orig./CB) [Deutsch] Das im PASCO Programm untersuchte Verbundcontainment fuer zukuenftige Leichtwasserreaktoren ist ein erfolgversprechendes rein passives System zur Nachwaermeabfuhr nach einem schweren Stoerfall. Die passiven Mechanismen der Waermeuebertragung sind Naturkonvektion und Waermestrahlung. Die durch Waermestrahlung uebertragene Waerme betraegt fuer einen Emissionskoeffizienten von 0.9 etwa 50% der insgesamt ueber das Stahl-Containment abgefuehrten Waerme und ist somit von entscheidender Bedeutung fuer die Nachwaermeabfuhr. Fuer die waermeuebertragenden Oberflaechen ist ein hoher Emissionkoeffizient erforderlich. Das im SUCO Programm untersuchte Sumpfkuehlkonzept realisiert eine stabile Naturkonvektionsstroemung zwischen Waermequelle und Waermesenke. (orig./DG)

77 FR 63753 - Suspension of Community Eligibility

Science.gov (United States)

2012-10-17

.... Henderson, Township of, 420960 January 21, ......do Do. Huntingdon County. 1974, Emerg; August 3, 1989, Reg.... Huntingdon County. Emerg; November 1, 1985, Reg; October 16, 2012, Susp. West Virginia: Falling Springs...

Measuring Variance in Subnational Regimes: Results from an Expert-Based Operationalization of Democracy in the Argentine Provinces Midiendo la variación de los regímenes subnacionales: Resultados de una operacionalización basada en expertos de la democracia en las provincias argentinas

Directory of Open Access Journals (Sweden)

Carlos Gervasoni

2010-01-01

Política Provincial (EEPP y se realiza un análisis preliminar de sus resultados. Algunos aspectos de los regímenes provinciales aparecen como claramente democráticos, mientras que otros son mixtos o incluso se inclinan hacia el autoritarismo. Además, algunos muestran escasa variación interprovincial, mientras que otros varían considerablemente de provincia a provincia. Un análisis de la tendencia central y la dispersión de los ítems de la encuesta permite una descripción general de los regímenes provinciales argentinos. La dimensión más democrática es la inclusión, mientras que la efectividad de los límites institucionales al poder del Ejecutivo es la más deficiente. La competencia electoral no es en general afectada por formas tradicionales de fraude, pero los oficialismos a menudo gozan de mucho mayores niveles de recursos de campaña y atención mediática que sus oponentes. La represión física es poco habitual, pero los opositores en algunas provincias enfrentan formas más sutiles de castigo. Aunque la encuesta no descubre ningún caso claro de autoritarismo subnacional en sentido estricto, los regímenes provinciales varían significativamente desde los que son básicamente democráticos hasta los claramente híbridos.

Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression.

Science.gov (United States)

Wang, Rui; Wan, Qi; Kozhaya, Lina; Fujii, Hodaka; Unutmaz, Derya

2008-07-16

Regulatory T (T(reg)) cells control immune activation and maintain tolerance. How T(regs) mediate their suppressive function is unclear. Here we identified a cell surface molecule, called GARP, (or LRRC32), which within T cells is specifically expressed in T(regs) activated through the T cell receptor (TCR). Ectopic expression of GARP in human naïve T (T(N)) cells inhibited their proliferation and cytokine secretion upon TCR activation. Remarkably, GARP over-expression in T(N) cells induced expression of T(reg) master transcription factor Foxp3 and endowed them with a partial suppressive function. The extracellular but not the cytoplasmic region of GARP, was necessary for these functions. Silencing Foxp3 in human T(reg) cells reduced expression of GARP and attenuated their suppressive function. However, GARP function was not affected when Foxp3 was downregulated in GARP-overexpressing cells, while silencing GARP in Foxp3-overexpressing cells reduced their suppressive activity. These findings reveal a novel cell surface molecule-mediated regulatory mechanism, with implications for modulating aberrant immune responses.

Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression.

Directory of Open Access Journals (Sweden)

Rui Wang

2008-07-01

Full Text Available Regulatory T (T(reg cells control immune activation and maintain tolerance. How T(regs mediate their suppressive function is unclear. Here we identified a cell surface molecule, called GARP, (or LRRC32, which within T cells is specifically expressed in T(regs activated through the T cell receptor (TCR. Ectopic expression of GARP in human naïve T (T(N cells inhibited their proliferation and cytokine secretion upon TCR activation. Remarkably, GARP over-expression in T(N cells induced expression of T(reg master transcription factor Foxp3 and endowed them with a partial suppressive function. The extracellular but not the cytoplasmic region of GARP, was necessary for these functions. Silencing Foxp3 in human T(reg cells reduced expression of GARP and attenuated their suppressive function. However, GARP function was not affected when Foxp3 was downregulated in GARP-overexpressing cells, while silencing GARP in Foxp3-overexpressing cells reduced their suppressive activity. These findings reveal a novel cell surface molecule-mediated regulatory mechanism, with implications for modulating aberrant immune responses.

Culture promotes transfer of thyroid epithelial cell hyperplasia and proliferation by reducing regulatory T cell numbers.

Science.gov (United States)

Kayes, Timothy D; Braley-Mullen, Helen

2013-01-01

IFN-γ(-/-) NOD.H-2h4 mice develop a spontaneous autoimmune thyroid disease, thyroid epithelial cell hyperplasia and proliferation (TEC H/P) when given NaI in their water for 7+ mo. TEC H/P can be transferred to IFN-γ(-/-) SCID mice by splenocytes from mice with severe (4-5+) disease, and transfer of TEC H/P is improved when splenocytes are cultured prior to transfer. Older (9+ mo) IFN-γ(-/-) NOD.H-2h4 mice have elevated numbers of FoxP3(+) T reg cells, up to 2-fold greater than younger (2 mo) mice. During culture, the number of T reg decreases and this allows the improved transfer of TEC H/P. Co-culture with IL-2 prior to transfer prevents the decrease of T reg and improves their in vitro suppressive ability resulting in reduced TEC H/P in recipient mice. Therefore, culturing splenocytes improves transfer of TEC H/P by reducing the number of T reg and IL-2 inhibits transfer by preserving T reg number and function. Copyright © 2013 Elsevier Inc. All rights reserved.

76 FR 5284 - Suspension of Community Eligibility

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2011-01-31

..., 1975, ......do Do. County. Emerg; September 4, 1986, Reg; February 18, 2011, Susp. St. Paul, Town of...; November 17, 1982, Reg; February 18, 2011, Susp. Cherry Valley, Village of, 170721 February 18, 1975...

The World Factbook

Science.gov (United States)

1994-01-01

Lago de Yojoa (the country’s largest source of freshwater) with heavy metals as well as several rivers and streams Ptarturc hazairds: subject to... Madre de Dios , Apurimac), La Rafael REY Rey; Democratic Coordinator, ( 1994 est.) Libertad (from La Libertad), Los Jose BARBA Caballero, Democratic... Madre de Dios . Moquegua. Pasco. Judicial branch: Supreme Court of Justice mining and telecommunications industries. In Piura. Puno. San Martin. Tacna

An illustrated key to powder post beetles (Coleoptera, Bostrichidae associated with rubberwood in Thailand, with new records and a checklist of species found in Southern Thailand

Directory of Open Access Journals (Sweden)

Wisut Sittichaya

2009-10-01

Full Text Available An illustrated key to seventeen species of Bostrichidae recorded in association with rubberwood in Thailand is provided. A checklist is given of nine species infesting rubberwood sawn timber in sawmills in southern Thailand, with information on distribution, host trees and biology. Three species are recorded for the first time from Thailand: Cephalotoma tonkinea Lesne, Lyctoxylon dentatum (Pascoe, and Minthea reticulata Lesne.

Geologic thickness data: Candidate repository horizons

International Nuclear Information System (INIS)

Cross, R.W.; Fairchild, K.R.

1985-01-01

This data package contains information on the thickness of the Umtanum, McCoy Canyon, Cohassett, and Rocky Coulee flows and their intraflow structures in 20 boreholes and 2 surface sections in the Pasco Basin. Thickness data are for total flow, flow top, entablature, and colonnade (or just flow top and dense interior in some cases). Summary figures which contain descriptions and footages are included

A new species of the Brenthid genus Stratiorrhina, Pascoe

NARCIS (Netherlands)

Ritsema Cz., C.

1882-01-01

Length (the rostrum included) 29 mm., width of the shoulders of the elytra 5 mm. — Opaque, with the exception of the narrowed portion of the rostrum and the elytra which are subshining. Very narrow pale yellow scales are scattered over the whole insect, the antennae and legs inclusive, but with the

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Indian Academy of Sciences (India)

2002-06-30

Jun 30, 2002 ... and university departments will be held at the Sf. Stephen's College, University of Delhi, Delhi. The broad aim of the Refresher Course is to help motivated teachers to improve and refresh their understanding of some basic courses in theoretical physics. The level of all the proposed sessions in this.

A paleolimnological perspective on industrial-era metal pollution in the central Andes, Peru

Energy Technology Data Exchange (ETDEWEB)

Cooke, Colin A. [Department of Geology, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Earth and Atmospheric Sciences, University of Alberta, Edmonton, AB, T6G 2E3 (Canada)], E-mail: cacooke@ualberta.ca; Abbott, Mark B. [Earth and Atmospheric Sciences, University of Alberta, Edmonton, AB, T6G 2E3 (Canada); Section of Anthropology, Carnegie Museum of Natural History, Pittsburgh, PA 15206 (United States)

2008-04-15

To date, few studies have investigated the environmental legacy associated with industrialization in the South American Andes. Here, we present an environmental archive of industrial pollution from {sup 210}Pb-dated lake cores recovered from Laguna Chipian, located near the Cerro de Pasco metallurgical region and Laguna Pirhuacocha, located near the Morococha mining region and the La Oroya smelting complex. At Laguna Chipian, trace metal concentrations increase beginning {approx} 1900 AD, coincident with the construction of the central Peruvian railway, and the rapid industrial development of the Cerro de Pasco region. Trace metal concentrations and fluxes peak during the 1950s before subsequently declining up-core (though remaining well above background levels). While Colonial mining and smelting operations are known to have occurred at Cerro de Pasco since at least 1630 AD, our sediment record preserves no associated metal deposition. Based on our {sup 14}C and {sup 210}Pb data, we suggest that this is due to a depositional hiatus, rather than a lack of regional Colonial pollution. At Laguna Pirhuacocha, industrial trace metal deposition first begins {approx} 1925 AD, rapidly increasing after {approx} 1950 AD and peaking during either the 1970s or 1990s. Trace metal concentrations from these lakes are comparable to some of the most polluted lakes in North America and Europe. There appears to be little diagenetic alteration of the trace metal record at either lake, the exception being arsenic (As) accumulation at Laguna Pirhuacocha. There, a correlation between As and the redox-sensitive element manganese (Mn) suggests that the sedimentary As burden is undergoing diagenetic migration towards the sediment-water interface. This mobility has contributed to surface sediment As concentrations in excess of 1100 {mu}g g{sup -1}. The results presented here chronicle a rapidly changing Andean environment, and highlight a need for future research in the rate and magnitude

75 FR 79033 - Proposed Extension of Existing Information Collection; Radiation Sampling and Exposure Records...

Science.gov (United States)

2010-12-17

... daughters are invisible and odorless. Decay of radon and its daughters results in emissions of alpha energy..., or viewed on the Internet by selecting ``Rules & Regs,'' and then selecting ``FedReg.Docs.'' On the...

77 FR 9856 - Suspension of Community Eligibility

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2012-02-21

... County. Emerg; October 15, 1985, Reg; March 2, 2012, Susp. King, Township of, Bedford 421342 May 11, 1984... County. 1974, Emerg; January 26, 1983, Reg; March 2, 2012, Susp. Snake Spring, Township of, 421349...

78 FR 25585 - Suspension of Community Eligibility

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2013-05-02

..., ......do Do. County. Emerg; September 16, 1982, Reg; June 18, 2013, Susp. Hannibal, Town of, Oswego 360651 September 6, 1985, ......do Do. County. Emerg; February 1, 1988, Reg; June 18, 2013, Susp. Hannibal, Village...

Initial Examination of Low Velocity Sphere Impact of Glass Ceramics

Energy Technology Data Exchange (ETDEWEB)

Morrissey, Timothy G [ORNL; Fox, Ethan E [ORNL; Wereszczak, Andrew A [ORNL; Ferber, Mattison K [ORNL

2012-06-01

This report summarizes US Army TARDEC sponsored work at Oak Ridge National Laboratory (ORNL) involving low velocity (< 30 m/s or < 65 mph) sphere impact testing of two materials from the lithium aluminosilicate family reinforced with different amounts of ceramic particulate, i.e., glass-ceramic materials, SCHOTT Resistan{trademark}-G1 and SCHOTT Resistan{trademark}-L. Both materials are provided by SCHOTT Glass (Duryea, PA). This work is a follow-up to similar sphere impact studies completed by the authors on PPG's Starphire{reg_sign} soda-lime silicate glass and SCHOTT BOROFLOAT{reg_sign} borosilicate glass. A gas gun or a sphere-drop test setup was used to produce controlled velocity delivery of silicon nitride (Si{sub 3}N{sub 4}) spheres against the glass ceramic tile targets. Minimum impact velocities to initiate fracture in the glass-ceramics were measured and interpreted in context to the kinetic energy of impact and the elastic property mismatch between sphere and target material. Quasistatic spherical indentation was also performed on both glass ceramics and their contact damage responses were compared to those of soda-lime silicate and borosilicate glasses. Lastly, variability of contact damage response was assessed by performing spherical indentation testing across the area of an entire glass ceramic tile. The primary observations from this low velocity (< 30 m/s or < 65 mph) testing were: (1) Resistan{trademark}-L glass ceramic required the highest velocity of sphere impact for damage to initiate. Starphire{reg_sign} soda-lime silicate glass was second best, then Resistan{trademark}-G1 glass ceramic, and then BOROFLOAT{reg_sign} borosilicate glass. (2) Glass-ceramic Resistan{trademark}-L also required the largest force to initiate ring crack from quasi-static indentation. That ranking was followed, in descending order, by Starphire{reg_sign} soda-lime silicate glass, Resistan{trademark}-G1 glass ceramic, and BOROFLOAT{reg_sign} borosilicate glass

75 FR 38749 - Suspension of Community Eligibility

Science.gov (United States)

2010-07-06

.... Emerg; January 6, 1982, Reg; July 22, 2010, Susp. Phenix City, City of, Lee 010184 May 24, 1976.... Unincorporated Areas. Emerg; July 22, 2010, Reg; July 22, 2010, Susp. Kentucky: Guthrie, City of, Todd 210214...

Firefighter Math - a web-based learning tool

Science.gov (United States)

Dan Jimenez

2010-01-01

Firefighter Math is a web based interactive resource that was developed to help prepare wildland fire personnel for math based training courses. The website can also be used as a refresher for fire calculations including slope, flame length, relative humidity, flow rates, unit conversion, etc. The website is designed to start with basic math refresher skills and...

Simulation of the summer circulation over South America by two regional climate models. Part I: Mean climatology

Science.gov (United States)

Fernandez, J. P. R.; Franchito, S. H.; Rao, V. B.

2006-09-01

This study investigates the capabilities of two regional models (the ICTP RegCM3 and the climate version of the CPTEC Eta model - EtaClim) in simulating the mean climatological features of the summer quasi-stationary circulations over South America. Comparing the results with the NCEP/DOE reanalysis II data it is seen that the RegCM3 simulates a weaker and southward shifted Bolivian high (BH). But, the Nordeste low (NL) is located close to its climatological position. In the EtaClim the position of the BH is reproduced well, but the NL is shifted towards the interior of the continent. To the east of Andes, the RegCM3 simulates a weaker low level jet and a weaker basic flow from the tropical Atlantic to Amazonia while they are stronger in the EtaClim. In general, the RegCM3 and EtaClim show, respectively a negative and positive bias in the surface temperature in almost all regions of South America. For both models, the correlation coefficients between the simulated precipitation and the GPCP data are high over most of South America. Although the RegCM3 and EtaClim overestimate the precipitation in the Andes region they show a negative bias in general over the entire South America. The simulations of upper and lower level circulations and precipitation fields in EtaClim were better than that of the RegCM3. In central Amazonia both models were unable to simulate the precipitation correctly. The results showed that although the RegCM3 and EtaClim are capable of simulating the main climatological features of the summer climate over South America, there are areas which need improvement. This indicates that the models must be more adequately tuned in order to give reliable predictions in the different regions of South America.

Global changes in the proteome of Cupriavidus necator H16 during poly-(3-hydroxybutyrate) synthesis from various biodiesel by-product substrates.

Science.gov (United States)

Sharma, Parveen K; Fu, Jilagamazhi; Spicer, Victor; Krokhin, Oleg V; Cicek, Nazim; Sparling, Richard; Levin, David B

2016-12-01

Synthesis of poly-[3-hydroxybutyrate] (PHB) by Cupriavidus necator H16 in batch cultures was evaluated using three biodiesel-derived by-products as the sole carbon sources: waste glycerol (REG-80, refined to 80 % purity with negligible free fatty acids); glycerol bottom (REG-GB, with up to 65 % glycerol and 35 % free fatty acids), and free fatty acids (REG-FFA, with up to 75 % FFA and no glycerol). All the three substrates supported growth and PHB production by C. necator, with polymer accumulation ranging from 9 to 84 % cell dry weight (cdw), depending on the carbon source. To help understand these differences, proteomic analysis indicated that although C. necator H16 was able to accumulate PHB during growth on all three biodiesel by-products, no changes in the levels of PHB synthesis enzymes were observed. However, significant changes in the levels of expression were observed for two Phasin proteins involved with PHB accumulation, and for a number of gene products in the fatty acid β-oxidation pathway, the Glyoxylate Shunt, and the hydrogen (H2) synthesis pathways in C. necator cells cultured with different substrates. The glycerol transport protein (GlpF) was induced in REG-GB and REG-80 glycerol cultures only. Cupriavidus necator cells cultured with REG-GB and REG-FFA showed up-regulation of β-oxidation and Glyoxylate Shunt pathways proteins at 24 h pi, but H2 synthesis pathways enzymes were significantly down-regulated, compared with cells cultured with waste glycerol. Our data confirmed earlier observations of constitutive expression of PHB synthesis proteins, but further suggested that C. necator H16 cells growing on biodiesel-derived glycerol were under oxidative stress.

HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.

Directory of Open Access Journals (Sweden)

Yorifumi Satou

2011-02-01

Full Text Available Human T-cell leukemia virus type 1 (HTLV-1 is the causal agent of a neoplastic disease of CD4+ T cells, adult T-cell leukemia (ATL, and inflammatory diseases including HTLV-1 associated myelopathy/tropical spastic paraparesis, dermatitis, and inflammatory lung diseases. ATL cells, which constitutively express CD25, resemble CD25+CD4+ regulatory T cells (T(reg. Approximately 60% of ATL cases indeed harbor leukemic cells that express FoxP3, a key transcription factor for T(reg cells. HTLV-1 encodes an antisense transcript, HTLV-1 bZIP factor (HBZ, which is expressed in all ATL cases. In this study, we show that transgenic expression of HBZ in CD4+ T cells induced T-cell lymphomas and systemic inflammation in mice, resembling diseases observed in HTLV-1 infected individuals. In HBZ-transgenic mice, CD4+Foxp3+ T(reg cells and effector/memory CD4+ T cells increased in vivo. As a mechanism of increased T(reg cells, HBZ expression directly induced Foxp3 gene transcription in T cells. The increased CD4+Foxp3+ T(reg cells in HBZ transgenic mice were functionally impaired while their proliferation was enhanced. HBZ could physically interact with Foxp3 and NFAT, thereby impairing the suppressive function of T(reg cells. Thus, the expression of HBZ in CD4+ T cells is a key mechanism of HTLV-1-induced neoplastic and inflammatory diseases.

77 FR 29692 - Segun M. Rasaki, M.D.; Decision and Order

Science.gov (United States)

2012-05-18

... CFR 1316.67. Dated: May 4, 2012. Michele M. Leonhart, Administrator. Paul E. Soeffing, Esq., for the... reinstatement.'' Stuart A. Bergman, M.D., 70 Fed. Reg. 33,193 (DEA 2005); Roger A. Rodriguez, M.D., 70 Fed. Reg...

Evaluation of a polyherbal topical aerosol spray as a supportive therapy for clinical mastitis in dairy cows

Directory of Open Access Journals (Sweden)

Ramasamy Selvam

2015-09-01

Full Text Available The present study was designed to evaluate the polyherbal topical aerosol spray Wisprec and reg; Advanced (M/S. Natural Remedies Private Limited, India as a supportive therapy for clinical mastitis in dairy cows. A total of 41 dairy cows suffering from clinical mastitis were selected, and Wisprec and reg; Advanced was sprayed on mastitis affected quarters of udder two times a day along with a parenteral antibiotic till complete recovery. The rectal temperature, pain on palpation of udder, swelling of udder, consistency of milk, recovery period and product satisfaction score were assessed to evaluate the efficacy of Wisprec and reg; Spray. Topical application of Wisprec and reg; Advanced Spray have shown a significant improvement (p<0.001 in alleviation of rectal temperature, pain on palpation of udder and swelling of udder, and the consistency of milk was restored to normal after 3 to 4 days of treatment. The results demonstrate that the Wisprec and reg; Advanced spray could be considered as an alternative to non-steroidal anti-inflammatory drugs (NSAIDs as a supportive therapy for clinical mastitis of dairy cows. [J Adv Vet Anim Res 2015; 2(3.000: 285-290

Radiographers' professional knowledge regarding parameters and safety issues in plain radiography: a questionnaire survey.

Science.gov (United States)

Farajollahi, A R; Fouladi, D F; Ghojazadeh, M; Movafaghi, A

2014-08-01

To review the knowledge of radiographers and examine the possible sociodemographic and situational contributors to this knowledge. A questionnaire survey was devised and distributed to a cohort of 120 radiographers. Each questionnaire contained two sections. In the first section, background data, including sex, age, highest academic level, grade point average (GPA), length of time from graduation, work experience as a radiographer and the status of previous refresher course(s), were collected. The second section contained 17 multiple-choice questions concerning radiographic imaging parameters and safety issues. The response rate was 63.8%. In univariate analytic model, higher academic degree (p workplace (p = 0.04) and taking previous refresher course(s) (p = 0.01) were significantly associated with higher knowledge score. In multivariate analytic model, however, higher academic degree (B = 1.62; p = 0.01), higher GPA (B = 0.50; p = 0.01) and taking previous refresher course(s) (B = -1.26; p = 0.03) were independently associated with higher level of knowledge. Age, sex, length of time from graduation and work experience were not associated with the respondents' knowledge score. Academic background is a robust indicator of a radiographer's professional knowledge. Refresher courses and regular knowledge assessments are highly recommended. This is the first study in the literature that examines professional knowledge of radiographers in terms of technical and safety issues in plain radiography. Academic degree, GPA and refresher courses are independent predictors of this knowledge. Regular radiographer professional knowledge checks may be recommended.

The World Factbook 2002

Science.gov (United States)

2002-01-01

branch: unicameral Congress of the Economy -overview: Thanks to strong foreign Madre de Dios , Moquegua, Pasco, Piura, Puno, San Republic of Peru or...Ancash), Grau (from FIM 1, others 17 presidential election and FUJIMORI’s subsequent Tumbes, Piura), Inca (from Cusco, Madre de Dios , Judicial branch...current issues: air pollution from G R E E C E industrial emissions; rivers polluted from raw sewage, . / heavy metals , detergents; deforestation

New records and observations of some species of Elaphoglossum (Elaphoglossaceae) of Peru

OpenAIRE

Mellado, Leopoldo F.; León, Blanca

2013-01-01

Elaphoglossum cardioglossum Mickel y Elaphoglossum molle (Sodiro) C. Chr. son reportados para la fl ora peruana, de colecciones realizadas en Cusco y Pasco. Por primera vez es descrito material fértil de Elaphoglossum alipes Mickel, Elaphoglossum alipes Mickel, Elaphoglossum alipes Elaphoglossum atropunctatum Mickel, Elaphoglos- sum cardioglossum Mickel y Elaphoglossum haynaldii (Sodiro) I. Losch. También se actualizan Elaphoglossum haynaldii (Sodiro) I. Losch. T ambién se actualizan Elaphogl...

75 FR 2930 - Proposed Collection; Comment Request for Regulation Project

Science.gov (United States)

2010-01-19

... DEPARTMENT OF THE TREASURY Internal Revenue Service [REG-106446-98] Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and... From Joint and Several Liability. OMB Number: 1545-1719. Regulation Project Number: REG-106446-98...

Loss of Visual Working Memory within Seconds: The Combined Use of Refreshable and Non-Refreshable Features

Science.gov (United States)

Ricker, Timothy J.; Cowan, Nelson

2010-01-01

We reexamine the role of time in the loss of information from working memory, the limited information accessible for cognitive tasks. The controversial issue of whether working memory deteriorates over time was investigated using arrays of unconventional visual characters. Each array was followed by a postperceptual mask, a variable retention…

Writing Clinic for Business and Technical Writers.

Science.gov (United States)

Mercer County Community Coll., Trenton, NJ.

This document offers brief lesson plans for four courses: (1) an 8-hour refresher course for employees who write memos, short reports, and letters; (2) an 8-hour refresher course on creating a short document; (3) a 16-hour course on technical manual writing; and (4) an 8-hour course on technical manual writing. The courses were part of a workplace…