Full Text Available Türk bahçesi üzerinde Batı etkisinin görülmeye başladığı dönem “lale devri”’dir. İdare ve siyasi yönden bir gerileme başlangıcı olan bu dönem kısalığına rağmen, güzel sanatlar ve peyzaj açısından önemlidir. III. Ahmet başta olmak üzere devlet büyükleri ve zenginlerinin yaptırdıkları, kağıthane vadisinden başlayarak, Haliç ve Boğaz kıyılarına yayılan sayısız sahil-saray, saray, köşk ve yalıların bahçe ve koruları ile İstanbul bir “bahçe ve su şehri” görünümüne bürünmüştür. Avrupa’da Rönesans ve Barok bahçe modası yerini İngiliz natüralist bahçelerine bırakırken, Türk bahçesi Barok bahçelerinin güzellik ve ihtişamı ile büyülenmekte idi. Bu devrin en karakteristik eserleri Topkapı Sarayı bahçeleri ve Üsküdar Sarayları’nın bahçeleri olarak karşımıza çıkmıştır. Osmanlı mimarisinin Avrupa etkilerine açılması, 28. Mehmet Çelebi’nin 1720-1721 yılları arasında Fransa’yı ziyareti ile başlayan bir girişimin dolaylı ürünü olmuştur. Bu devirde şiir, edebiyat ve müzikle birlikte bahçe sanatında da büyük gelişmeler olmuş, saray ekranı İstanbul’da manzaraya hakim güzel yerlerde bahçeli saray, köşk ve yalılar yaptırarak zevkü sefa sürmeye başlamışlar. Bunların arasında Beşiktaş’taki Çırağan Sarayı ile Kağıthane Vadisi’ndeki Sadatabad Sarayı ve Üçyüz Köşk bu döneme ait en önemli örnekler olarak değerlendirilmiştir. Lale devri mimarisinde doğrudan doğruya Batı’dan aktarılan “biçimler” görülmemiş ancak lale devri le birlikte baş gösteren ve genel tasarlama eğiliminde kavranabilen yenilikler olmuştur. Lale devrindeki batıya açılış Türk bahçelerinde de benzer düzenlemelerin ortaya çıkmasına yol açmıştır. 1720’lerdeki Fransız elçisi aracılığı ile bu ülkeden bahçe düzenleyicileri getirilmiştir. 19. Yüzyılın başında III. Selim’in kızı kardeşi Hatice Sultan’ın mimarı olarak çalışmış olan Melling, onun Beşiktaş’taki Sarayı’nın bahçesini Fransız bahçelerine benzeterek geometrik yol ve tarhlarla düzenlenmiştir. Bu daha sonra pek çok saray ve konak bahçelerine örnek olmuştur
Martson, Ilona, 1970-
India lauljatari Kakoli Sengupta kontsertidel Eestis saab sõna Doris Kareva, kes kannab ette Põhja-India pühaku Kabiri 15. sajandil loodud poeesiat; vt. ka fotod Kroonika (2003) nr. 40, 30. sept., lk. 54
Aug 8, 2011 ... Acacia mangium as a phytoremediator of copper contaminated soil. Nik M. Majid, M. M. Islam*, Veronica Justin, Arifin Abdu and Parisa Ahmadpour. Department of ... The different levels of Cu were: T0 (control, soil), T1 (50 ppm Cu), T2 (100 ppm ..... aspects such as photosynthesis and respiration rate need.
see Reddy N Parvathala. 1065. Ahmad Irfan see Khan Ziauddin. 1011. Akhlaghi Parisa. The measurements of thermal neutron flux distribution in a paraffin phantom. 873. Amirhashchi Hassan. String cosmology in Bianchi type-VI0 dusty. Universe with electromagnetic field. 723. Aref Morteza see Feghhi Seyed Amir Hossein.
Ahmed, Rana; Borst,Jacqueline; Wei,Yong; Aslani,Parisa
Rana Ahmed,1 Jacqueline M Borst,2 Cheng Wei Yong,3 Parisa Aslani1 1Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia; 2Department of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands; 3School of Pharmacy, The University of Nottingham, Nottingham, UK Background: Attention-deficit/hyperactivity disorder (ADHD) is the most prevalent pediatric neurodevelopmental condition, commonly treated using pharmacological agents such as stimulant medicines. The use o...
Stone, J. R.
A method for predicting the effects of flight on jet mixing noise has been developed on the basis of the jet noise theory of Ffowcs-Williams (1963) and data derived from model-jet/free-jet simulated flight tests. Predicted and experimental values are compared for the J85 turbojet engine on the Bertin Aerotrain, the low-bypass refanned JT8D engine on a DC-9, and the high-bypass JT9D engine on a DC-10. Over the jet velocity range from 280 to 680 m/sec, the predictions show a standard deviation of 1.5 dB.
Full Text Available Parisa Emami-Naeini, Ali Mahdavi, Hamed Ahmadi, Nima Baradaran, Farideh NejatDepartment of Neurosurgery, Children’s Hospital Medical Center, Medical Sciences/University of Tehran, Tehran, IranAbstract: Dermal sinuses have been associated with a wide spectrum of clinical manifestations ranging from asymptomatic to drainage of purulent material from the sinus tract, inclusion tumors, meningitis, and spinal abscess. To date, there has been no documented report of brain abscess as a complication of spinal dermal sinus. Here, we report an 8-month-old girl who was presented initially with a brain abscess at early infancy but lumbar dermal sinus and associated spinal abscess were discovered afterwards. The probable mechanisms of this rare association have been discussed.Keywords: brain abscess, spinal dermal sinus, spinal abscess
Full Text Available Yuen H Kwok,1 James E Swift,1 Parisa Gazerani,2 Paul Rolan1 1Discipline of Pharmacology, University of Adelaide, Level 5 Medical School North, South Australia, Australia; 2Department of Health Science & Technology, Aalborg University, Aalborg, Denmark Background: Chronic migraine (CM is problematic, and there are few effective treatments. Recently, it has been hypothesized that glial activation may be a contributor to migraine; therefore, this study investigated whether the potential glial inhibitor, ibudilast, could attenuate CM. Methods: The study was of double-blind, randomized, placebo-controlled, two-period crossover design. Participants were randomized to receive either ibudilast (40 mg twice daily or placebo treatment for 8 weeks. Subsequently, the participants underwent a 4-week washout period followed by a second 8-week treatment block with the alternative treatment. CM participants completed a headache diary 4 weeks before randomization throughout both treatment periods and 4 weeks after treatment. Questionnaires assessing quality of life and cutaneous allodynia were collected on eight occasions throughout the study. Results: A total of 33 participants were randomized, and 14 participants completed the study. Ibudilast was generally well tolerated with mild, transient adverse events, principally nausea. Eight weeks of ibudilast treatment did not reduce the frequency of moderate to severe headache or of secondary outcome measures such as headache index, intake of symptomatic medications, quality of life or change in cutaneous allodynia. Conclusion: Using the current regimen, ibudilast does not improve migraine with CM participants. Keywords: chronic migraine, glia, ibudilast, headache, immune system
Ariya, P.; Kos, G.
Gregor Kos (1), Nafissa Adechina (2), Dwayne Lutchmann (2) , Roya Mortazavi, and Parisa Ariya* (1), (2) (1) McGill University, Department of Atmospheric and Oceanic Sciences, 805 Sherbrooke Street West, Montreal, Quebec, H3A 2K6, Canada (2) McGill University, Department of Chemistry, 801 Sherbrooke Street West, Montreal, Quebec, H3A 2K6, Canada an active medium for the deposition of (semi-)volatile (bio)organic compounds. We collected surface snow samples during the OASIS Barrow campaign in March 2009 for analysis of semi-volatile organic compounds using solid phase microextraction and gas chromatography with mass spectrometric detection (SPME-GC/MS). Additioal gab samples were taken for analysis of non-methane hydrocarbons in air. More over, we analyzed for microbial species in air and snow. Identifed organic compounds covered a wide range of functionalities andmolecular weigts, including oxygenated reactive speces such as aldehydes (e.g., hexanal to decanal), alcohols (e.g., hexanol, octanol) and aromatic species (e.g., methyl- and ethylbenzenes). Quantification data for selected aromatic species are presented with concentrations in the upper ng/L range. We will present our preliminary data on microbiological species, and will discuss the potential mplications of the results for organic snow chemistry.
Full Text Available Richard Amini, Lori A Stolz, Parisa P Javedani, Kevin Gaskin, Nicola Baker, Vivienne Ng, Srikar Adhikari Department of Emergency Medicine, University of Arizona Medical Center, Tucson, AZ, USA Background: Emergency medicine milestones released by the Accreditation Council for Graduate Medical Education require residents to demonstrate competency in bedside ultrasound (US. The acquisition of these skills necessitates a combination of exposure to clinical pathology, hands-on US training, and feedback. Objectives: We describe a novel simulation-based educational and assessment tool designed to evaluate emergency medicine residents’ competency in point-of-care echocardiography for evaluation of a hypotensive patient with chest pain using bedside US. Methods: This was a cross-sectional study conducted at an academic medical center. A simulation-based module was developed to teach and assess the use of point-of-care echocardiography in the evaluation of the hypotensive patient. The focus of this module was sonographic imaging of cardiac pathology, and this focus was incorporated in all components of the session: asynchronous learning, didactic lecture, case-based learning, and hands-on stations. Results: A total of 52 residents with varying US experience participated in this study. Questions focused on knowledge assessment demonstrated improvement across the postgraduate year (PGY of training. Objective standardized clinical examination evaluation demonstrated improvement between PGY I and PGY III; however, it was noted that there was a small dip in hands-on scanning skills during the PGY II. Clinical diagnosis and management skills also demonstrated incremental improvement across the PGY of training. Conclusion: The 1-day, simulation-based US workshop was an effective educational and assessment tool at our institution. Keywords: point-of care ultrasound, simulation education
Full Text Available Fatemeh Ranjbar,1 Homayoun Sadeghi-Bazargani,2,3 Parisa Niari Khams,1 Asghar Arfaie,1 Azim Salari,4 Mostafa Farahbakhsh1 1Clinical Psychiatry Research Center, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan, Iran; 2Road Traffic Injury Research Center, Department of Statistics & Epidemiology, Tabriz University of Medical Sciences, Tabriz, Iran; 3World Health Organization Collaborating Center on Community Safety Promotion, Karolinska Institute, Stockholm, Sweden; 4Emam Khomeini Hospital, Naghadeh, West Azerbaijan, Iran Background: Antipsychotics have been used for more than 50 years in the treatment of schizophrenia and many other psychiatric disorders. Prolactin levels usually increase in patients treated with risperidone. Aripiprazole, which has a unique effect as an antipsychotic, is a D2 receptor partial agonist. It is an atypical antipsychotic with limited extrapyramidal symptoms. Since it acts as an antagonist in hyperdopaminergic conditions and as an agonist in hypodopaminergic conditions, it does not have adverse effects on serum prolactin levels. The present study aimed to investigate the effect of aripiprazole on risperidone-induced hyperprolactinemia. Methods: This before-and-after clinical trial was performed in 30 patients. Baseline prolactin levels were measured in all patients who were candidates for treatment with risperidone. In subjects with elevated serum prolactin, aripiprazole was added to their treatment. Serum prolactin levels were measured during the first week, second week, and monthly thereafter for at least 3 months or until prolactin levels became normal. The data were analyzed using Stata version 11 software. Survival analysis and McNemar’s test were also performed. Results: The mean age of the participants was 30.8 years. Prolactin levels normalized in 23 (77% participants during the study, and menstrual disturbances normalized in 25 (83.3%. Prolactin levels normalized in most patients between days 50
Full Text Available Parisa Yousefpour1, Fatemeh Atyabi2, Ebrahim Vasheghani-Farahani3, Ali-Akbar Mousavi Movahedi1, Rassoul Dinarvand21Department of Biotechnology, Faculty of Science, University of Tehran, 2Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, 3Biotechnology Group, Department of Chemical Engineering, Faculty of Engineering, Tarbiat Modares University, Tehran, IranBackground: Targeting drugs to their sites of action to overcome the systemic side effects associated with most antineoplastic agents is still a major challenge in pharmaceutical research. In this study, the monoclonal antibody, trastuzumab, was used as a targeting agent in nanoparticles carrying the antitumor drug, doxorubicin, specifically to its site of action.Methods: Chitosan-doxorubicin conjugation was carried out using succinic anhydride as a crosslinker. Trastuzumab was conjugated to self-assembled chitosan-doxorubin conjugate (CS-DOX nanoparticles (particle size, 200 nm via thiolation of lysine residues and subsequent linking of the resulted thiols to chitosan. Conjugation was confirmed by gel permeation chromatography, differential scanning calorimetry, Fourier transform infrared spectroscopy, and 1H nuclear magnetic resonance spectroscopy studies. Dynamic light scattering, transmission electron microscopy, and zeta potential determination were used to characterize the nanoparticles.Results: CS-DOX conjugated nanoparticles had a spherical shape and smooth surface with a narrow size distribution and core-shell structure. Increasing the ratio of doxorubicin to chitosan in the conjugation reaction gave rise to a higher doxorubicin content but lower conjugation efficiency. Trastuzumab-decorated nanoparticles (CS-DOX-mAb contained 47 µg/mg doxorubicin and 33.5 µg/mg trastuzumab. Binding of trastuzumab to the nanoparticles was further probed thermodynamically by isothermal titration calorimetry. Fluorescence microscopy demonstrated enhanced and
Full Text Available Rana Ahmed,1 Jacqueline M Borst,2 Cheng Wei Yong,3 Parisa Aslani1 1Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia; 2Department of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands; 3School of Pharmacy, The University of Nottingham, Nottingham, UK Background: Attention-deficit/hyperactivity disorder (ADHD is the most prevalent pediatric neurodevelopmental condition, commonly treated using pharmacological agents such as stimulant medicines. The use of these agents remains contentious, placing parents in a difficult position when deciding to initiate and/or continue their child's treatment. Parents refer to a range of information sources to assist with their treatment decision-making. This qualitative study aimed to investigate 1 parents' ADHD-related knowledge pre- and post-diagnosis, 2 the information sources accessed by parents, 3 whether parents' information needs were met post-diagnosis, and 4 parents' views about strategies to meet their information needs. Methods: Three focus groups (n=16 parents, each lasting 1.0–1.5 hours were conducted. Focus groups were audio-recorded and transcribed verbatim. Transcripts were analyzed using the framework method, coded, and categorized into themes. Results: Generally, parents had limited ADHD-related knowledge prior to their child's diagnosis and perceived prescription medicines indicated for ADHD in a negative context. Parents reported improved knowledge after their child's diagnosis; however, they expressed dissatisfaction with information that they accessed, which was often technical and not tailored to their child's needs. Verbal information sought from health care professionals was viewed to be reliable but generally medicine-focused and not necessarily comprehensive. Parents identified a need for concise, tailored information about ADHD, the medicines used for its treatment, and changes to their child's medication needs with age. They also expressed a
Benetoli, Arcelio; Chen, Timothy F; Aslani, Parisa
activities. Social media appears to be used as a key tool to support disease self-management. ©Arcelio Benetoli, Timothy F Chen, Parisa Aslani. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 13.10.2017.
Full Text Available Elyar Sadeghi-Hokmabadi, Mehdi Farhoudi, Aliakbar Taheraghdam, Mazyar Hashemilar, Daryous Savadi-Osguei, Reza Rikhtegar, Kaveh Mehrvar, Ehsan Sharifipour, Parisa Youhanaee, Reshad Mirnour Neurosciences Research Center, Neurology Department, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan, Iran Background: In developing countries, intravenous thrombolysis (IVT is available at a limited number of centers. This study aimed to assess the feasibility and safety of IVT at Tabriz Imam Reza Hospital. Methods: In a prospective study, over a 55-month period, any patient at the hospital for whom stroke code had been activated was enrolled in the study. Data on demographic characteristics, stroke risk factors, admission blood pressure, blood tests, findings of brain computed tomography (CT scans, time of symtom onset, time of arrival to the emergency department, time of stroke code activation, time of CT scan examination, and the time of recombinant tissue plasminogen activator administration were recorded. National Institutes of Health Stroke Scale assessments were performed before IVT bolus, at 36 hours, at either 7 days or discharge (which ever one was earlier, and at 3-month follow-up. Brain CT scans were done for all patients before and 24 hours after the treatment. Results: Stroke code was activated for 407 patients and IVT was done in 168 patients. The rate of functional independence (modified Rankin Scale [mRS] 0–1 at 3 months was 39.2% (62/158. The mortality rate at day 7 was 6% (10/168. Hemorrhagic transformation was noted in 16 patients (9.5%. Symptomatic intracranial hemorrhage occurred in 5 (3%, all of which were fatal. One case of severe urinary bleeding and one other fatal case of severe angioedema were observed. Conclusion: During the first 4–5 years of administration of IVT in the hospital, it was found to be feasible and safe, but to increase the efficacy, poststroke care should be more organized and a stroke center